>AmTRPM/1-1677 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------MAIGSIIC--------------------- ----------------------------------------------------------GASTPKMKRK---- ------------------------------------------------------------------------ ------------------------------------------------------------------------ KAKATERS---------------------------------------------------------------- ----------------------------------------------WIEATFQKRE----------CSK--- ---------------------------------------------FIPSAD-DEHKFMQVKGDKNAEYDVIT TSRCCCGYS-YTHHCRA-GIDVQSYTLS----------------------------------------NTKE KDREQWSPAKNT---------------------------------------------------RPFPTDAYG TIEFQGGPHP--------------------------------TKAQYVR----------------------- ------------------LAYDTRPEPIVHL-LCRE--------WNLGLPKLLITVHGGR-S-----NFELQ PTLKK---------------------------------VLRKGLLKAAKTT--------------------- -----------------------------------GAWIFTGGTNTGV---------------TRQVGDAL- ---LLERSQ--------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------RQG---------------- ------------------------------------------------------------------------ ----------------------RVVSIGI------------------------------------------- ----------------------------------------APWG---------------------------- --------ILDKSHEL-------------VG-----RG---------------------------------- GEVSY----DCLS--------------SPWSKYAVLNNRHAYFLLVDNG-------------TGGRYG-AE- ---------IVLRRRL--EK-------------YISNLKLQPYTHS-------------------------- -----------------------------------SIPV--VALVIEGGTNTIRSVLE--YVTDVP------ -----------------------------------------------PVPVVVCDG-----------S-GRA ADLIAFMHKYASEGDGENGDIEGPLESMREHLLDTIKRTFKVSAEQASQ-------------LYSELLQ--- --CTRKK------HLITVFRIS---------------------------QERP-----QEL----------- -----------------------------DQ-T-I--------------LTALFKSKQ-------------- ---------LSPAE----------QLSL-------------------------------------------- ------------------------------------------------------------------------ ------------SL------------------------IWNRVD---------------------------- ------IA------------RCEIFVYGQNWP---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------PGAL----------------------EQAMMQALQH----D------------------------R IDFVK--------------------------------LLLEN-G--VSMRKFLSI--------PRL------ --------------------------------------EELYNT-------------KEGPSNT-LGYILRD --------------------VRP-NIPRGYMYTLHDIGLVINKLMGGAYRSQYT-----------RRRFRMI YTKVMKRSGAHPQ--------HLHRNSCILG-------------------NTTRYYSGS--------GSKQD SLTMSLL-----------------------------------AETLPANRDTPL----------FD-YPFNE LLIWAV--------------LTKRQ---------QMALLMWQHGEEALA----------------------- -KALVALKLYKAMAHEAAED---------------------------------------------------- ----------------------DLETEVYDELR--SYGKEFENIGTNICDFCYRQDDD-------------Q TKQLLTSELQ-------------------------------------------------------------- -------------------------------------------------NWSGQTCLSLAVTAN-H-----R PLLAHPCSQ-----------IILADL--------------------------------------WM------ ----------------GGLR--TRKNTNLKVV------LGLICPFYII--CLEFK----------------- -SREELQLMPQTQEEHLI------------------------ALEDEKEDSD-------------------- -----SEHG-----------------------------IPTGPDVEALISNEH----TTTIVKE-------- TIVQENGKV------------------------LTDNDDGIHRAYGIHS--------------DYYDIKNSR PLRLR-----------KKLY--------EFYTAPITKFWANAIAYMIFLVLFSYSI-------------LIH MDD--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------HPSLAEIYAIAYICTLGC---------EKVR-EI--ATS----EPA-----------TLSH KFSVWA-W----------NMWNPCDAAA-------------------IIFFQIGLALRLR------------ -------------------------------------------------HST-LDVGRVIY----CVDCIYW YLRILNILG----------------------------------------------VNKYFGP--LVTMMGKM VK-NMTYFVVLLIVVLLSF--GVTRQAILNPN-------------------AE------------------- -------------------------------------------PKFRIIRD--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------I----- ---------------------FMEPYFMLYGEVY--ADNID---------------PDCGD----------- -------EPGMIP-CLPGR---------------------------WITP----AVMSIYLLIANILLINLL IAVFNNIFNEVNAVAHQVWMFQRFTVV------------------------MEYEQK--------------- ---PVLP-------PP--------------------LIVVCHIYLVVK----------YLLR-------YIT QGKA----------------SS-G---------ETYDNGLKLFLEA------DDMERLYDFEEDCVEGYFR- -------------------------EQELKLQMST------------------------------------- ------------EERVKITTER-VENMHSKIEDIDKKENTQNA----------------SLQAVEFRIRKLE ELNEQTLAHLGVIHRFMATHMP------------------NI------EGLSNFDIEG-RQRRVSERSE--- --------------------------V------------LSE--TDSH--TQLPTITAKRKRLVRSMT---- -----DATF-----LNLGP----------------SLD------DDIMKHSET-------IMSR-------- ----------------------------------------ENLS--------------------RNESSISG DG-----------------------------HIIQDDIKTTTS-------------Q-ETE-------FS-- ----KIDGER-ETIKKDSQSD-----------------SR---------ETSREPSE------EPSSKEPST ---------------DPS-R-QTSRDL--SRE-----TSKDATSKE------------------------PS REASSE------------------------APA----SEPIRQDSIERPI---------------------- ------------------------------------------------------------------------ -------------RQNSRT-RSES----DDI----------------------------------------- --------------------MILPS-NIPRGV-T-WA-----------------EPRVA------------- ------------------------------------------------------------------------ ----------------------------------VIPSVS-----STNT---------QRSILLA------- -------------MRAEYTSITDE---------------------------------------------LES YC-GLLSPPRTP------------PISPP--------PSRVRNLSEMSNP------EMAWQIEN----EHLR DAEECDYQQMEDLIQRRYIADDEPL------------HVSDEASGG-----------------------SFF IS---------NEHRH------Q---LRRT-----SAID-----------------------------EES- -----RRP-------P-PTISV-------------------------------------------------- ------------------------------------------------------------------------ --------------------------------------------------TREIEQTL-------------- ----------------------------------------------SRP-PIRDSENSDP------------ ------------------------------------------------------------------------ ---------------------------------------------NDKN-LSTVPAPASETMC--------- >AmTRPML/1-631 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------MSEPRKR------ ------------------------------------------------------------------------ -----------------------------------------------------------------------M VKDESRGNILRNHS---------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------W-------------SNGPDSE-- ------------------------------------------------------------------------ --------------------------------DEQA---------------------GEN-E---------- --------------------------------------LLNEC----------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------SVS--------------------------------- PS---------------------------------------------------------------------- --------------------------------HHRSTITDQPICNMS------------------------- -------------------------------------LF---------TEEKMRRKLK-------------- ---FF--------------------------------------------FMNPIEKWQ---------AKRRF PYKFIV------------------------------------------------------------------ -------------QVIKILLV--------------------------------------------------- --------------------------------T-I---------------QLCLFAHNN------------- ---------YIHVNYTWDNRIAFSHLFLRGWDSS-------------------------------------- ------------LE---------------------------------------------------------- -VPVYPPVTGPLAI-------------------YKRDDFYNTID---------------------------- ------YALDGYYNVSN-AVGSYSY----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ IAENNSVGPVILCLYQYKEG----------------IIFGFN----E---------------SYVFD----K -EIIETC--------INITD-----KTYTESSKSKL-LLFKQ-N--IKV----NF----------------- --------------------------------------SALVRAH--------------------LMFALKT VNLKA-------------------------------------AGPMTPPDC--------------------- ------------------------------------------------------------------------ -------------------------------------------------------------------YQFNI KIN-----------------FDNRD----------------------------------------------- FDGQMLLSLD-------------------------------------------------------------- -------------------------------------------AEPKRLQ-CKGDTRYVT-----DNRIESA LRTLLNLFVI-------------------------------------------------------------- -------------------LICTV-----------------------------------------SLILCSR AIYRAQLLKFETM-------NFFKKAYGKILSLEGRLEFLNL----------------------WY------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------VMIIVNDLLIIM---G-----SAIKEQI--------------------------- ERKQFG-S----------DHWNICSIFL-------------------------------------------- -----------------------------------------------------------------GTGNLLV WFGVLRYLG----------------------------------------------FFKTYNV--VILTLKKA AP-KVARFLICAILIYAGF--TFCGWLILGPYH--------------------------------------- --------------------------MK--------------------FRS-L------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------ATT----- ---------------------SECLFALINGDDM--FATFSATSFSK------------------------- ---------------------------------------SPML--WWYSR----MYLYTFISLYIYVVLSLF ISVIMDAYDTIK---------------------------------------IYYRDGF-------------- ------P---------------------------------------------KNDLQTFI------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------AAC-TDEASS------------------------------------------- ------------------------------------------------------------------------ -------------------------GL-----------------YKDDS----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------EDSD---------------------- ------------------------------------------------------------------------ ------------LSEFIDR----------------------------------------------------- ------------------------------------------------------------------------ ------------FCCCRKR----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------P-------------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------------------FYGSFSESSTK------------ -------------------------------------------------FSTKSEQTCGGAICI-------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ >AmWtrw/1-1258 MAV---------IFTRFVNIQNAINNNNFGSLKNTWNIVQYSGVIFKSYCVNNLKNNISFDNSKKGKK--IS KVMKIY------------------------------------------------------------------ ------------------------------------------------------------------------ -LERSREYQNFIRK--------ETLE---------------------------------------------- --------------------------------YNIGKRNLAK------------------------------ --------------------------------------------------------MMG-EDPD-------- -------------------------------------------NFTKENIKNAISYLFPSGIYDKEARPMMA DPEELYAREKEAEFNEDGRPHHF-----------------------------LYYTIKPNYYEILHKM---- VESITYLNKIED------------------------------------------------------------ -----------------------------------KFLLI-----NHKIDEDKKID-L-------------N GSDWLEKSKLENILLEKLSDSEYEYFIKSMQRLADHPVSKHVEPFIMEYRKSLT------------------ -----------KTNENIELPKPQYDNDNRPFVLIEKCQRKSSIGQVKVIGNGSGNITINGQDITYFSDMYCR EQVRNVDMEN---VTVSIPSTPKRTTMTSLLLTRWLTSKSSTRTNPETSWSSDDRSLEY-----GTPPPIEE PHCYSMCAS----------------------------------ESSCTE----------------------- -------EINCTLQ----VNKDIIKNLLVEH-MRHI-G-------------------GRL-Q--------LL DDLEE------------------------------------NKMDLKNTENFAK-L--YKQH---------- ------------------------------------------EINALLLHSSFLGHVDAIKSLHKC-GADL- ---NHSEQG--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------QGL--------------------------------------------------------- TPLHL---------------------CAFSN-----CLEGVQYLLD--------------------NG-AN- ---------IHL------ERT--------------------------------------------------- -----------------------------------HTPF--HYAAFGNACKVAQYFLQ-------------- --------------------------------------------LGI--SQESC------YGE-------ET VLHSAARSDA-------------------------------------------------------------- ------Y------NVLKLLAP-----------------------------NNP------TL----------- -----------------------------DN-L-----DCNGY-------AAIHHVAD-------------- ---------RGDPSCL--------TVLLDA-GCK-LDLTT-------------------------------- ------------------------------------------------------------------------ -------KKNDTAL--------HLAAA---------ASCVENVD---------------------------- ------LLV---------ERGANVHLRN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---HRDQTAL--------------------------HIAARS----H------------------------S LECVE--------------------------------ILLKK-GG-CDPN-IEDS-------DGR------- --------------------------------------TPLHLALGR----------SLLAYDV-TEFLITW KAN------------------------------------------VNKTDK-Y------------------- --------------------------GYT------------------------------------------- --------------------------------------------------------------------PLHI AA------------------LNELS---------QCVDILIQHGADLSA-RTK------------------- -GGTSALSII-------------------------------------------------------------- -------------------------------LR--KTP-TSLNVFKQRLDASITLHQHG-------SA-TGE AELRLDFHP--------------------------------------------------------------- LLMN--------------------------------------------QQQGEIRYLGTFVKEG-Y-----K EILEHPLCQ-----------AFLHLK--------------------------------------WQ------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------K------------------- ----------------IRKY-----------------YVGRLIFYLFYVLILTGWV-------------MTA L-------------------------------------------------AHNCY----------------- -NE-----------SHGQLD-------N---GQ---P----------------PLC---------------- ------------------------------------------------------------------------ ----ANTTGINGFLYRHPA----------------------------------LLE---------------- --------------VEWYALMVLTILEVF---------RKLT-SIPTYP----------------------- CVRQFF-T----------QAENMVEW-C----------------------VILSVFATSF------------ ----------IYTG-----------------R-----------TY-PWQS--------HVG----AFAVLCG WSNLMLMIG----------------------------------------------QLPIFGA--YVAMFTSV QA-QVFKLLLAYACLLVGF--TASFCVIF----------------------PR------------------- --SKS-------------------------------------------FSS-P------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------HIG----- ---------------------LIKVLVMMTGELN--FEDLFFPHEED-------------GKT--------- ------IDSGSTSWIL-------------------------L---QVSAQ----LSFVLFLLFVTIVLMNLL VGIAVHDIKGLQKTAGLAKLVRQTKLI------------------------CDVETALFLGLM--------- ------P------------------------------------KRLM----------KFLRW---------- --TA-LLL----------------------------PSPLRAV--------------------LTV------ --------------------------RPLNPRESR------------------------------------- -----------------LPRDL-LATA--------HKV-------------------------AKER-K--- ---------------------------------NCISG-------------TLYNRKRN----AVYACLKSE PYLTFRR------------------NF----PEEE----------IS------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------TID--------------------DYA------------ ------------------------------------------------------------------IKGE-- ------------------------LA-----------------EL--------------------------- ------------------------------------------KKICERNHQ--------------------- ------------------------------------------------------------------------ -----------LLQDIV------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------LMLV---------N DKR--------------------------------------------------------------------- ---------------------------E-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >AmelGB11954/1-1267 -----------------------MSCSR-------------------------VPEN-------------YV ANLDAVR--------------------------------------------------------VCAKPI--- ------------------------------------------------------------------------ ---RGKDWMKRER---------------------------------MSVSE--------------------- ---------------------------------SAHKDEEHGAGGARS------------------------ --------------------------------------------------------PGESGLGEEIGAPD-- ---------------------------------------------EDCAH---------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------LALRMDTNT----------S----- ------------------------------------------------RGW--------------------- ----------NSGGRAF-LRGIGQ------------------------------------------------ -------RVSFD---------------------------------------------------PEAPP---- ------------------------------------------------------------------------ ------------------P--PSQP----------------------------------------------- --------------------------------------------AR-------------------------- ------------------------------------------------------------------------ ----KIDEKVK------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------RHS---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------IHG---------------------------- --------MIE-------------------------EE---------------------------------- NVVR------------------------PH---------------------------------------QE- ---------MASLSYQ--EK---------------------------------------------------- -------------------------------------KY--LLAVERGDVASVRRMLQ--SAQET------- ---------------------------------------------E--MNINCVDP-----------L-GRS ALLMAI------------------------------------------------------------------ --DNENL------EMVELLI-E------------------------------------HKV----------- -----------------------------DT-K-----------------DALLHAIS-------------- ---------EEFVEAV--------EVLLEH------------------------------------------ ------------EE---------------------------------------------------------- ------------SL--------HRNGEPHE-QSECRNESWEALP---------------------------- ------S-------------DTATFTPDI------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------TPL--------------------------ILAAHR----D------------------------N YEIIK--------------------------------ILLDR-G--STLPMPHDV----------------- ------------------------------------------RC------GCDECVTS-RREDS-LRHSRSR ---------------------------------------------INAYRALAS------------------ ------------------------------------------------------------------------ PSLIALSSK----------------------------------------------------------DPI-- ------------------------------------------------------------------------ ---LTAFELSWELRRLSF------------------------------------------------------ -----------------------LEHEFKCEYQ--ELRRQCQDFATALLDHTRSSYE--------------- LEVLLNH-----------------------------------------D----------------------- --PTG-PA-------------------------------FEHG------ERMHLNRLKLAIKLR-Q-----K KFVAHPNVQ-----------QLLASI--------------------------------------WY------ ----------------EGLPGFRRKNMVLQALEIVK--IGVLFPFFSV--AYIIAP---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------HCVVG--------QTMRKPFIKFICHSASYFTFLFMLILAS--------------QR IESVIG--------------------------------------------NW--M----------------- ---------------------------G-------------------------------------------- ------------------------------------------------------------------------ ------RD-VVE--QDTVP----------------------------------------------------- ------TKRGAAPTIIEWFILAWVSGLIW---------SEVK-QL--WDV---------------------- GLEEYV-N----------DMWNVIDFVT-------------------NSLYVATAALRVVAYYRVKWEI-EK SGSE------VELQ-----------------RE-------------QWDTWDPMLISEGLF----SAANIFS SLKLVYIFS----------------------------------------------VNPHLGP--LQVSLSRM VM-DIMKFFFLYVLVLFAF--SCGLNQLLWYYADMEKKRCPTAM-SYAP--NAS---------VT------- TDSNA------------------------------------C-IVWRRFAN-L------------------- --------------------------------------------FE-------------------------- ------------------------------------------------------------------T----- ---------------------TQTLFWAVFGLVD--LESFE------------------------------- ---------------LDGI--------------------KAFT--RFWGM----LMFGTYSVINIVVLLNLL IAMMNHSYQLISERADIEWKFARSKLW------------------------ISYFEE--------------- --GGTVP-------PP--------------------FNIIPTPKSVWY-------MGQWLYR-------KLC GHSR----------------AAKK----------EHMRTIRRKV--------KQASERDFRYQSIMRNLVR- --------------------------RYVTVEQRK------------------------------------- ------------AESEGVTEDD-VNEIKQDISALRCELIEIL------------------------KNSGMN TSTASG-----------------------------TGTG------------AGGKKNRQKER---------- -------------------------RL------------MKG--FN-----------------IAPQPSGSG SLPPVDEFA---------------------------------ASLQQAQQENS----HE-LFGSTLSGIFG- ----------------------------------------PGTTP------------------KKSPH---- -----------------------------------HTSTNSVP-----------------G----------- ---------------------------------------------------------------LGTSRQSRR ----------------IRGSSKKK----------------RWENL-----------------------IEAA KVRGKVSRLI--GR---------------------------SRSEDSVY----------------------- ------------------------------------------------------------------------ ------------SPASEDGGSRSEG--STDSKS--------------------------------------- ---------SLEQG---------------------------------------------------------- ------------------------------------------------------------------------ ------------------------ANDGQP--TH-HPHH------AHH---SHHHE--GGHHVFPHGLG--- ----ALV------------ALRKKRKTFSDSRSSTS---------GM---------------------RSGS GTNP-------------------------------IYPLATALVSKVSR---------KQQLQR-ASSVPTR GPE--------------------------------------------------------------------- --------------------------LGQQPI----------------------------------P----- ---------------P-RRHEG-TQSQQPSI----------------------------------------D T----------PEGASANEQPDRF------V-------CVV------------------------------- --------------------------------------------------CEVVPAAP-------------- ----------------------------------------------LTPSTTEESV-AASTSLPATMKR--- ------------------------NGSATQLQRL----------------------PG-------------- ----------IEPISGHD-------------------------------------------VSGGWL----- >AmelGB15944/1-1018 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------M-------------------- -------------------------------------------------GC--------------------- ----------EKTEKEV-EA---------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------PP----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------T------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------EEN---------------- ------------------------------------------------------------------------ ---------------------AYLIHFP-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------KSLNIE--EK---------------------------------------------------- -------------------------------------KY--LLAVERGDLVNVKRFIQ--YANKS------- --------------------------------------------HGKSMDINCVDS-----------L-GRG ALCLSI------------------------------------------------------------------ --DSENL------EMVKLLV-V------------------------------------MGI----------- -----------------------------ET-K-----------------DALLRAID-------------- ---------QEFVEAV--------EFLLEH------------------------------------------ ------------EE---------------------------------------------------------- ------------LLTANSMENNSEKEVIH---------SWQKID---------------------------- ------P-------------ASARYPPEI------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------TPL--------------------------ILAAQR----N------------------------N YEILK--------------------------------LLLDR-G--ATLPMPHDI----------------- ------------------------------------------RC------GCADCLRS-TIGDP-LRISSTR ---------------------------------------------VSEYKALAS------------------ ------------------------------------------------------------------------ PSLIALSSP----------------------------------------------------------DPL-- ------------------------------------------------------------------------ ---LTAFN---------------------------------------------------------------- --------------------------ELGTSRI--DDCR-TGKFAVDLLQQVRTTTE--------------- LHTILNY-----------------------------------------D----------------------- --PED-DA-------------------------------NLPP------K--QLARLELAIQYK-Q-----K TFVAHSHVQ-----------QLLAAI--------------------------------------WY------ ----------------DGLPGFRRMSTGKRCGILAK--TALMFPFYCM--MYLIAP---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------ESKIG--------QLMRKPFVKFLVHASSYLFFLFILMLVS--------------QR AEIEIV--------------------------------------------RL--F----------------- ---------------------------G-------------------------------------------- ------------------------------------------------------------------------ ------SDETIKNMDIELT----------------------------------------------------- ------KQRGAAPSLLEFIVILYVIGFIW---------QEMR-EA--YID---------------------- GLKGYL-R----------DMWNFIDFTR-------------------NFLYIATAILRLVAYLQQKAEIRDN PSAA-------LIP-----------------RE-------------NWSDFDPQLIAEGLF----AAANINS ALKLIHLFS----------------------------------------------INPHLGP--LQISLGRM VI-DIVKFFFIYTLVLFAF--ACGLNQLLWYFAELERQKCYV-D--------------FADPSWD------- PASDN------------------------------------C-LRWRRFSN-L------------------- --------------------------------------------FE-------------------------- ------------------------------------------------------------------S----- ---------------------CQSLFWASFGGIG--IESFE------------------------------- ---------------LTGI--------------------KSYT--RFWGL----LMFGSYSVINVIVLLNLL IAMMSNSYAVIEERADKEWKFARTKLW------------------------MSYFED--------------- --SGTLP-------PP--------------------FNIIPPPKLFL----------------------RLC GLRK----------------IT------------GKMSDCKRA--------------RDSKYGAVMKALIW- --------------------------RYIVNTHSE------------------------------------- ------------HEMNPVTEDD-VHELKSDLSSWRCELLEIL------------------------RRNGMD IASADT-----------------------------KERT------------ILGKKMKVWER---------- -------------------------RL------------MKD--FQ-----------------VTVPLS--- --------------------------------------------IDEDQMESF------------------- ----------------------------------------QQ-----------------------TNE---- ----------------------------------EEDNIAKWK--------------RIAK----------- ---------------------------------------------------------------LAVLQSANH ----------------------------------------RWNQV-----------------------LDSA V-KS--SQI---GK---------------------------STSKSSIQNQIS------------------- ------------------------------------------------------------------------ -----------LKKAMEEAQKLNNK--STLPP---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------VSLA--- ------------------------------SKPVMSMDYIDE----------------------------KS AK------------------------IVP------PQQLKRKSLNSSTT---------YQQQPE-MLSSHST NT---------------------------------------------------------------------- --------------------------FKYTAS--SP------------------------------------ ------------------------------------------------------------------------ -----------------------IKKSGSGT----E------------------------------------ ---------------------------------------------------SLSAHMD-------------- ----------------------------------------------EIPKTLKS------------------ ----------------------RLKPTLSPKKNLNMPEDKEKLV---------NVMP--------------- ----------RSPRGPSKSP----------------------------RK-------------GGWL----- >AmelGB16264/1-873 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------M-------------------- -------------------------------------------------NP--------------------- ----------SESQQNL-LAD--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------DARAP------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------SV----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ QSLN------------------------AP---------------------------------------TD- ----------YALGPV--EK---------------------------------------------------- -------------------------------------HF--LLSAERGDCATVKRLLL--ENKD-------- --------------------------------------------HPEILNINCVDP-----------L-DRS ALIAAI------------------------------------------------------------------ --ENENI------ELIKLLL-E------------------------------------LGI----------- -----------------------------QV-K--------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------SWEAVD---------------------------- ------K-------------SSSNFTPDI------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------TPL--------------------------ILAAHK----N------------------------N YEILK--------------------------------ILLDR-G--ATLPTPHDA----------------- ------------------------------------------RC------GCDECVTS-SEQDS-LRHSQAR ---------------------------------------------INAYRALTS------------------ ------------------------------------------------------------------------ PSLIALSSR----------------------------------------------------------DPL-- ------------------------------------------------------------------------ ---LTAFELSWELRRLSR------------------------------------------------------ -----------------------MEQEFRFEYE--EMRELTQNFATSLLDHARTSLE--------------- LEIMLNY-----------------------------------------N----------------------- --PYG-DN-------------------------------WEPG------ERQTLDRLKLAIKYK-Q-----K QFVAHPNVQ-----------QLLAAI--------------------------------------WY------ ----------------DGLPGFRRKNMVGQFIDVGK--LAAMFPVYSS--IYMLSP---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------TSPMG--------LFMKKPFVKFICHSSSYAFFL----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------SLIL---------GEIR-SL--WSD---------------------- GLMEYI-S----------DLWNIVDFVQ-------------------NMFYVIWIMLRITAWIIVQKEYRS- GLDP-------WYP-----------------RD-------------QWHAFDPMLLSEGAF----AAGMIFS FLKLVHIFS----------------------------------------------VNPHLGP--LQISLGRM II-DIIKFFFIYTLVLFAF--GCGMNQLMWYYADLEKQKCYNIK-------DF-----PDLPDFD------- NQEKA------------------------------------C-SIWRRFAN-L------------------- --------------------------------------------FE-------------------------- ------------------------------------------------------------------T----- ---------------------SQSLFWASFGMVD--LMSFD------------------------------- ---------------LTGI--------------------KSFT--RFWAL----LMFGSYSVINVIVLLNML IAMMSNSYQIISERSDTEWKFARSHLW------------------------MSYFED--------------- --GDTVP-------PP--------------------FNMIPTSKTFN----------------------KVL SCGK----------------A------------GRQTRSLIKK----------SREKAMARHDTVMRLLIR- --------------------------RYVTAEQRK------------------------------------- ------------RDQFGITEDD-VMEIRQDISTLRYELIDIL------------------------RQNGMR TPMLEK-----------------------------QDAAI-----------S-GKKGRVMER---------- -------------------------RL------------QKD--FQ-----------------IGIVEG--- ------------------------------------------------------------IVNAVI------ ------------------------------------------------------------------QS---- ----------------------------------EKEPKDVFS--------------QIAK----------- ---------------------------------------------------------------AIGRKSS-G --------------------SKKK----------------DWNAV--------------------------V R-QNTIAKDPI-GS---------------------------SNEAFEKQTRRS------------------- ------------------------------------------------------------------------ -----------IRRLGHQPNSD-LT--SLDPNR--------------------------------------- ---------LVDYN---------PN-LMEV------SPTTRIAYAK------FM---MRRP----------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------K----- ---------------P-AAGE--------------------------------------------------- ----------------------------------EEGKYIF------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------V----TFDIFAIHI----- >AmelHsTRPA/1-994 ------------------------------------------------------------------------ --MD-------------------------------------------------------------------- ------------------------------------------------------------------------ --------DKQIH----------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------ENST-------- -------------------------------------------DIPK------ASLQLPT-ITVGNERPRRY SLTSLKDR---------------------------------------------------------------- --RLPFENENDCGRAVEGEV----------EAHENVDKT--------------------------------- -------------------------------WQMKMKPL------ANHEKRTRHYS-LTRSKNRRSCLYTDE DRNFLTKSVVN----ETVND-------KTTQTLR-----------VPLSREGRTIHCS-------------- -----LSNLNDPSN------------D----LLSTRL----------------------------TSTFRSV R-YRQSSNSEKIAIDDIPPA---------------------------------DSSNDHVEIDAGTPPPVDE SLFYD-NL------------------------------------DVFRQ----------------------- ------------AQ----INSNDLRSIMWSI-VTTA----------------------EM-K--------IL LQLEK------------------------------------CN--------ALP-EIPAGER---------- ------------------------------------------IRNIAYMWCCYRNLAHLLPKLEQS-GVKL- ---DYVEPS--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------TGM--------------------------------------------------------- NAILA---------------------ASLSG-----SVACIEHLIK--------------------RG-VD- ---------INYRNP---INH--------------------------------------------------- -----------------------------------YTPL--HFAILGNSPDTARILLD-------------- --------------------------------------------NGA--KPSTY------LYQEV----AEP VLHCAIRAGA-------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------VEIVK---------------------------- ------LLL---------ERGASVVEKN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---HMGETPL--------------------------HVACFV----Q------------------------S IKCVE--------------------------------LLLDS-PG-TNVN-AVDR-------AHR------- --------------------------------------TPLHFAVMT----------TYSSAKL-VELLLKH GAL------------------------------------------VNAADK-T------------------- --------------------------GFT------------------------------------------- --------------------------------------------------------------------PLHV AA------------------LNEQS---------HCVDVLIWAGADVSA-TTS------------------- -AGLSALNII-------------------------------------------------------------- -------------------------------LR--KIP-DSLQVFRQRLDASITLRRPV-------PH-NRE FEMRLHFDL--------------------------------------------------------------- LFPS--------------------------------------------GNQCETSFINTFVQER-R-----K DLLSHPLVM-----------AFLHLK--------------------------------------WE------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------K------------------- ----------------IRKF-----------------YLLRILVYAMTVICMTTYV-------------LTA L-------------------------------------------------AYKCY----------------- -NH-----------DEANSS---------------------------------KIC---------------- ------------------------------------------------------------------------ ----SSKRISGFLFRRP------------------------------------VIE---------------- --------------IQWYLLLIFTCISIP---------RKIF-GFMVYT----------------------- SAKQYF-S----------NIDNVLDG-V----------------------VIISVFVTSF------------ ----------VYTG-----------------R-----------TY-DWQN--------YVG----AFAILCA WTNLMLMVG----------------------------------------------QLPAFGT--YVAMFTHI QF-EFAKLLLAYSGLLIGF--TISFCVIF----------------------VG------------------- --EPS-------------------------------------------FGN-P------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------FTG----- ---------------------LIKVLAMMAGELD--FEGLITQIDQG------------LES---------- -------DG---PFVIYH----------------------PL---SVCSQ----ILFTLFIVFVTVILMNLL VGIAVHDIQGLRNHAGLTKLVRQTKLI------------------------LFTEMVLHNSSI--------- ------P------------------------------------YAFR----------KWMS----------- --DH-KIN----------------------------VENRRRV--------------------LVV------ --------------------------KPLNPLEKR------------------------------------- -----------------LPKDI-LKAA--------YEI-------------------------AQKN-I-PF MNDEN---------------------------INLSDH-------------VIKMRQHSEE----------- -------------------------------------YFDSN--LQL------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------VIE--------------------NLANK---------- ---------------------------------------------------------------LQSYEDM-- ------------------------IK-----------------SL--------------------------- ------------------------------------------KEQLLDTNK--------------------- ------------------------------------------------------------------------ -----------MLESVVKN----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------LAK EKN--------------------------------------------------------------------- ---------------------------N-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >AmelIav/1-1167 ------------------------------------------------------------------------ --M-GGVCS--------------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------------------FRG------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------RGSQVN------ ------------------------------------------------------------------------ --------------------------------------------------------------A-GSIL---- DRVISQAS---------------------------------------------------------------- ---------------------------------------------DEDQCLLYRLA---------------- ------------------------NYKKGGELIES------------------------------------- --------YNQGGQ---------------------------------------------------------- ------FEVEKL------------------------------------------------------------ ------------------------------------------IREQFGVL---------------------- --------------------------------MYAD---------------------GKG-Q-----VINRA EYLRWKFRD--------------------------------------LEQVVLPIE---------------- --------------------------------------------------------------------ASL- ---SQFDPL--------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------AQ----------------- --------------------------------------------WND------------------------- -------------------------------------------------------------HE--------- ----------------------------------------ACWQ---------------------------- ---------MQYRGSLG-------------------E----------------------------------- TLLHV-------------------------------------LIIC-------------------------- ------------------------------------------------------------------------ -----------------------------------DTRI--HTR-------VARILLK-------------- ---CF---------------------------------------PRLAIDVVEGEEYL-----------GAS ALHLAI------------------------------------------------------------------ --AYNN------NELVQDLVE-----------------------------AGA------IISQRAIGSFFLP RDQQRTNP-------------------AKN--T-----DYEGLAY--LGEYPLAWAAC-------------- ---------CANESVY--------NLLLDS-GAD-------------------------------------- ------------PD---------------------------------------------------------- ----EQDSFGNMIL--------HMVVV---------CDKLDMFG---------------------------- ------YALR------HPKLPARNGIVN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---AAGLTPL--------------------------TLACQL----G------------------------R AEVFR--------------------------------EMLEL---------SARE-------FWRY------ --------------------------------------SNITCSA--------------------------- -------------------------------------------YPLNALDTLLP------------------ -------------------------DGRT------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -NWNSALFII-------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ LNGTKEE----------------------------------------------------------H-----L DMLDGGIIQ-----------RLLEEK--------------------------------------WK------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------T------------------- ---------------FAR-------------------FLKRLIILAFHLTSLSLAV-------------YLR PS---------------------------------------------------------------------- -------------------------------NTDAQ------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------LLK----------WPEE-- -----------ITEV---ARTIAECITVL---------GVLS-YI-LVQL--------GGE-------IINI GLLSFM-K----------QLSHEPAKLI----------------------FLISNLLILACIPCRLA----- -----------------------------GNRH--------------AED--------AIL----IVAVPGS WFLLMFFAGYVYVIVSWKVENTLGKLYKLLCLTDELVDALLMDHLFSKTCCISTQAVRLTGP-FVTMVYSMI TG-DMLTFGIIYMVVLFGF--CQSFYFLY----------------------KGF------------------ PGVKS-----------------------------------------SLYSS-Y------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------HST----- ---------------------WMALFQITLGDYN--YTDLSYT----------------------------- ----------------------------------------TY---PNLSK----MVFAIFMVLVPILLLNML IAMMGNTYAHVIEQSEKEWVKQWAKIV------------------------VSLERAVSQKDAQNYLQ---- --EYSIKLGPGDDPNN---------------------PAAEQRGVLII---------KSKSK---------- -TKA----------------KQRKGA----------VANWKRV------------------GKVTINELKKR GLTGEELRRIMWG-RASFS-------TPVRVSPKGVEPQ------VSVVT---------------------- ---------------AGFGDAL-TTALDV-MTFA-HDLDL-----------------STATEGIPTNIDAKQ SKPKSATKETKST----------------VNNQQNVTTNIEPL----KSTTENVDDQANNPR---EKKVTSQ AATVHEM------NLKNANHSSVTEDF---Q---------------DPLL-----------ELVIASE---- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------NTNDP---------------------------------- ------------------------------------------------------------------------ ----------------------ETLL-----------------EI--------------------AKRAAAG FETETS------SK----INLQILEQFTM-TKIPM-------DEKVNVTRKQYFV---------ESS----- ----DNDFG------------------GDNLLGT-------------------------------------- ---------EARLRRIRSANNRFI------TTRRRS------------------------------------ ------R--NVDDD------------LSSTSSTS-MDRNPRYQSLLNGHENSIDRP---------------- ------------------------------------------------------------------------ -----------------------IESREC------------------------------------------- -------------------SIEA------------------------------------------------- -----------------------------------INS-----------------------------QIKQN ------------------------------------------------------GPCETMKA---------- ---------------------------KVQKK--RPKTAR-------------------NRCINLQH-ADLD ---------------D-KDIETILH----------------------------------------------- ------------WHNTYRNTVASGKEIRGNPGPQRPAKFMM------------------------------- ---------------------------------------EVMWDDE----LALIARRWVVQCNLLEKDQCRD VGK--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ >AmelNan/1-792 ------------------------------------------------------------------------ --MGNTESNV-------------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------------------ASG------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------VKKQT------- ------------------------------------------------------------------------ --------------------------------------------------------------DASS------ ------------------------------------------------------------------------ -------------------------------------------------ILLYKLV---------------- ------------------------DLKGGGLLVDM------------------------------------- --------MKRATQTK-------------------------------------------------------- ----QYAELDHA------------------------------------------------------------ ------------------------------------------LRTKVEPY---------------------- --------------------------------LYNK---------------------GKG-K-----WIPIE KLVLLRNKDR-------------------------------------PKHKMLPPL---------------- --------------------------------------------------------------------RAM- ---ENP------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------AD----------------- --------------------------------------------YDI-DKD-----------MGED-EVDET KI-------------------------------DKSKY-----------------------RL--------- ----------------------------------------VCWS---------------------------- ---------LSERGAVG-------------------E----------------------------------- TILHL-------------------------------------CMLH-------------------------- ------------------------------------------------------------------------ -----------------------------------ATAI--HID-------LAKRLLR-------------- ---FY---------------------------------------PKLINDVYISDEYY-----------GES ALHIAI------------------------------------------------------------------ --VNED------PSMVKFLLD-----------------------------SGA------DVHERCIGNFMCP EDQKASRADS---------LDHEWVCVTPE--T-----NYNGYVY--WGEYPLNFAAC-------------- ---------LGQEECY--------RLILAR-GAD-------------------------------------- ------------PD---------------------------------------------------------- ----KQDTNGNTVL--------HMLVI---------YEKLATFD---------------------------- ------MAY---------EVGASLAIRN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---AQHLTPL--------------------------TLSAKL----A------------------------K IEMFF--------------------------------HILNI---------EREI-------YWQI------ --------------------------------------GSITCAA--------------------------- -------------------------------------------YPLSQVDTIDV------------------ ------------------------DTGSI------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -SHNSALNLV-------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ VFGEKDE----------------------------------------------------------H-----L ELMDG-ILV-----------DLLNAK--------------------------------------WN------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------T------------------- ---------------FVKFR-----------------FYRQFFLFCFYFVLSLISF-------------TLR PG---PATTSNDA-----KPID-------------------------------------------------- -ETVL-------------RI-------N---ST--------------ILFNGDGISFTSK------------ ------------------------------------------------------------------------ ---------------------------------------YNWWNNLTEE--CRLMH-------LDTLSTK-- ------------------IRLTAEVLMEI---------AATL-YI--FAA--------LRE-------ARFL GLNMFI-E----------NLMTAPSRVM----------------------FLFSCCILLTFPFLRLI----- -----------------------------CADE--------------IED--------MLA----VVVMLTT APYFLFFCR----------------------------------------------GFKTVGP-FVVMIYRMI MG-DLLRFVSIYLVFVMGF--SQAYYIIF----------------------LSF------------------ DNPNT------------PEGVDDS--------------------MSNPMPS-P------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------IES----- ---------------------IMAMFLMSMTNFGDYYGAFERT----------------------------- ----------------------------------------QH---EMEAK----FLFVVYMAIVAILLVNML IAMMGNTYQK-IAETRNEWQRQWARIV------------------------LVVERGVSPDERLKKLM---- --DYSQPMSDGRR-----------------------------ALVLRL---------NQS-E---------- -EDK----------------EEMKEI-----------LEMKRT------------------HDKLYKRRQSK ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------TMKK ILT--------------------------------------------------------------------- ---------------------------SEDN----------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------V-------------------IL----------------------------- >AmelNompC/1-1748 ------------------------------------------------------------------------ --MSSS------------------------------------------------------------------ ------------------------------------------------------------------------ -GSKRASGG--------------------------------------A------------------------ ----------------------------KDERKNASSKEESP-----VTGRDRDEGSGG------------- ---------TS--------------------ADGTP---------------------QPGSKP--------- ----------------------------------------------GSAGAS----------SREAVQK-LL ALAARGEWA-----PVDQLLKSLEKAAQSAGEDGGPLLPLASVMDPATGMTPLMYAVKDNR---TGLL---- DRMIELGADVGARNNDNYNALHVAAMYS----REDVVKLLLSKRSVDPYATGGPRQQTAIHLVASRQTGTAT SILRALLAAAGRDIRLKVD-------------GKGKIPLLLAVEAGNQS-MCREL--L-------------- -------------------------AQQAPDQLR-----------AT-TATGDSA----------------- --------LHLAAR---------RRDIDMVRILVDYGA---------------------------------- ----TVDMQNGD---------------------------------------------------GQTALHIAS ---------------------------------AEGDET--------------------------------- -----LVKYFYGVR----ASASITDHQDRTP-MHLA-AEN-----------------GHA-S--------II ELLADKFK-A--------------------------------SIFERTKDG--------------------- --------------------------------------------STLMHIASLNGHSECATMLFKK-GVYL- ---HMPNK---------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------RGA--------------------------------------------------------- RSIHT---------------------AAKYG-----HVGIISTLLQ--------------------RG-EK- ---------VDATTN---DNYTAL---------HIAVENAKPAVVETLLGYGAEVHVRGGKLRETPLHIAAR VAD--GDRCALMLLKSGAGPNLTTDDG--------QTPV--HVAASHGNLATLLLLLE-----DGGDPMCKS K-------NGETPLHLACRGCKA---DVVRHLIKFVKERRGAETATS--YVNSLTN-----------E-GAS GLHYAAQIEP-------------------------------------------------------SEVG--- -TAGDDR------AVIRALLE-----------------------------GGA------DVSLQTKQAQESA FHHCALAGNNEILSEMISGMSATEVQKALNR-Q-----SAVGW-------TPLLIAAH-------------- ---------RGHMELV--------TTLLAN-HAR-VDVFDLEGRSALHLAAEHGYLQVCDALLAN------- --------------------------------------------KAFIN----------------------- ----SKSRVGRTAL--------HLAAM---------NGYSHLVKFLVQDHGAAIDVLTLRKQTPLHLAAGAG QLEVCKLLL---------ELGASIDATDDQGQKPIHAAAMNNYAEVAQLFLQ---RHPSLVMACTKDGNTCA HIAAMQGSVRVIEELMKFDRQGVISARNKLTEATPLQLAAEGGHAEVVRALVRAGASCADENRAGFTAVHLA AQHGHGQVLEV-MR--SSQSLRISSKKLGVTALHVAAYFGQADTVRELLTHVPGTVKSDPPT---GGSLVGE LGSESGMTPL--------------------------HLAAYS----G------------------------N ENVVR--------------------------------LLLNSAG--VQVEAATTE-------NGF------- --------------------------------------NPLHLAC------------FGGHITV-VGLLLSR SAE-----------------------------------------LLHSSDR-Y------------------- --------------------------GKT------------------------------------------- --------------------------------------------------------------------GLHI AAT------------------HGHY---------QMVEVLLGQGAEINA-TDK------------------- -NGWTPLHCA---ARAG---------------------------------------YLDVVKLLVESGASPK SETNLGSAPIWFAASEGHN------DVLKYLME--KE----HDTYALMEDK--------------------- ---RFVYNM------------MVCS----KNNNNKPIEEFVLVSPAPVDTA-AKLSNIYMKLSEKEKERAKD LIAAGKQC-----------------EAMATELLALAAGADSAGRILTSMDRRNVEFLDVLIENE-Q-----K EVIAHTVVQ-----------RYLQEL--------------------------------------WQ------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------G------------------- ---------------SLNWN-----------------AFRTILLFVAFLVCPPVWV-------------VFA L----------------------------------------------------------------------- --------------PLGHKY-------N---NV--------------------------------------- ------------------------------------------------------------------------ ----------------------------------------------------PIIKFM-------------- -----------SYLTSHIYLMVFLLLVGI---------IPIY-PV--VRA---------S------------ -------L----------LP-YWYEWCLLVMLSGLLLFELTNPSDKSGLGWIKLAVLLFGICGVAFHLMGFV ----------IV-------------------------HRPYWPTLLYLRN--------QLF----ALSFLLA CVQILDFLS----------------------------------------------FHHLFGP--WAIIIGNL MK-DLARFLAVLAIFVFGF--SMHFVAL-------------------------------------------- --NQA-------------------------------------------FET--------------------- -------Q----------PDG-----------------------------------------GRRMDDKKK- ---KGVFNDD-----------------------------------------LLTNVTEW-----MMETPSTA PPRRYGRYKKKECCDDNSR--DIKMNPVLAFEYL--FFAVF------------------GQTT--------- ------HGE-LKVET-------------------------NQ---PQWTSVLFKLAFGVYMLVSVVVLINLL IAMMSDTYQRIQAQS-------------------------------------DIEWKY-------------- ------GL-----------------------------------SKLI----------RNMHR---------- --TT-----------------------------------------------------------TAP------ --------------------------SPLNL----------------------------------------- -----------------LTTWI-VYFIKV------CKQHA-----------------------AKRK----- -------------------------------RPSLVHM-----------MG-LQRAARLSPR---------- --------------------------------SKMGAKWLAK--VKK------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------GQ----------------------------------- ------------------------------------------------------------------VRPK-- ---------------------DSVTL-----------------SV--------------------VHLSP-- ---------------------------------------------LGSQLSF-------------NSATRIE NVVD------------------------WDSI---------------------------------------- ---------RKKYLALAGN----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------EPEK------------------------------------------------ --------------------------------------------------------------------EADK DAK--------------------------------------------------------------------- ---------------------------NEDEE--N------------------------------------E ---------------D-ENIHMVA------------------------------------------------ -------------NSSTIPTTATPPV---------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >AmelPain/1-892 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------MDLEDETLQMH---------------- ---------------------------------------------LLHDYTTNSIK---------------- ------------------------------------------------------------------------ ---------------------------------------------------------------SQTIY---- ------------------------------------------------KL---------------------- --------------------------------LLDY-LRT-----------------KNF-R-------HFK CLVEQNLK------------------------------KQPPIININ------------------------- ------------------------------------------------Y-------------AYPN------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------QSNE--------------------------------------------------------- TFLDI---------------------ACKNGL-----SEFVKFLLE--------------------KG-AK- ---------VN--RIN-EVHN--------------------------------------------------- -----------------------------------RGPI--HFATENGHADVLSILLD-------------- --------------------------------------------EPTI-NPNL-EV-----------V-QQT ALHIAVK----------------------------------------------------------------- ----KN----DL-KCASLLLE-----------------------------KGA------SP----------- -----------------------------NI-P-----NNKGL-------TALHIAAM-------------- ---------KDYRNMV--------NLILEK-TKHALNLDTYK----------DYNDQTARQILEKKIPNI-- SLPP--------IEKQNVNIHD--LKY-------YLNANDEMNFLRCLK-IVQNDMLN-N------------ -DI-------ETLI--------EMAVQ---------KNFKEAII---------------------------- ------LLL---------ERTKEIK----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---CNLEKAA--------------------------NLAIQR----G------------------------S PHILR--------------------------------QI---------LETDIEV-------KSD------- ---LL------------------------LNACIE-----LNIPHKG---GSQDM-S--DRLEC-FNLILER -----------------------------------------EDVDVRCID---------------------- ------------------------GKGNT------------------------------------------- --------------------------------------------------------------------PLHY AAK------------------ADCR---------EAVTLLLEKGSYIGH-MNN------------------- -FGIPPVADIS------------------------------------------------------------- -----------------------------------------ISTLSQYFDDCIVARK----------ERTNE YTIEFDYKC--------------------------------------------------------------- LMPH---------------------DNSYIINQQK--NFKNQEK-------REMDIFQYIASNN-S----LK HLLKHPLLS-----------SFLYLK--------------------------------------WH------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------R------------------- ----------------IRYI-----------------LYLNFAFYILFYLLLNIYI-------------LQI T----------------------------------------------------------------------- -----------------YVK-------N----T-------------QI------------------------ ------------------------------------------------------------------------ -ST-NSSEQMNGEIKN--S----------------------------------------------------- -------ISIYILQIFTGIMTALF---AF---------REIL-QL--LS----------------------- SPCHYM-L----------CLENWIEMTL----------------------IILGFSILNGATT--------- ----------------------------------------------------------QVA----AVTILLS AWELVILIG----------------------------------------------KHPRMST--GIEMFKTV SF-NFMRFLFLYAFLILAF--ALAFFILF----------------------KD------------------- GGNEN-------------------------------------------FPD-P------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------GHS----- ---------------------LFKTIIMLTGEFD--ANDIPFV----------------------------- ----------------------------------------SH---PILSH----FVFILFVFLIAIVLFNLL NGLAVSDTVNILEKAELVGLISRIRIL------------------------AYIENVIIQAPFTHGSY--CL I-------------------CSNLLSGWRC-------------NPL-----------AFLIQ---------- --KILLFPNY-----------------------------------------------LNS-GKLNVIS---- -------------------------YDSLETYESKL--YDKVELNKNSQNK----IIP-------------- -------IS-------KMDPDI-IKQAKN---------------------------------ILMKKGQESD N----------------------------------------------------------------------- -------------------------------------EKIFS------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------KLEK---------------------------------- ------------------------------------------------------------------LEKR-- -----------------FMTMEVILN-----------------SI--------------------------- ------------------------------------------KKKIENNNCN-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------ILEHEN---------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >AmelPyr/1-676 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------MC-------------GKS PLYYAVLSNA-------------------------------------------------------------- ------V------DCVKALLE-----------------------------AGA------SP----------- -----------------------------NN-P-----QVYTE-------TPLHVAAG-------------- ---------LGSIACT--------KLLLNY-GAD-VRVQF-------------------------------- ------------------------------------------------------------------------ ------GSMRSTPL--------HLAAE---------EGSVECTK---------------------------- ------LLL---------DAGATCEAKN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---ARGQAPM--------------------------HLAVLS----Q------------------------S METLE--------------------------------VLINI-G--ANVN-IEDN-------DNR------- --------------------------------------TPLHAAVAK----------TTRGIDL-VKILLQA GAL------------------------------------------INKADK-F------------------- --------------------------GYT------------------------------------------- --------------------------------------------------------------------PLHI AA------------------LNESS---------SIVIMLLSKGADVTA-RTK------------------- -GGISALSFI-------------------------------------------------------------- -------------------------------VR--RTP-DVLPRFISRLDQAISLHDH--------ELGDID CELKLDFRP--------------------------------------------------------------- LVSG---------------------------------------------GRGETDLMLCLVEVG-Q-----R HVLKHPLCE-----------SFLYLK--------------------------------------WL------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------R------------------- ----------------IRKF-----------------FLLNLIFHSIFVVFLTAYI-------------TIT Y-------------------------------------------------LSNIE----------------- -N----------------------------------T---------------EKF----------------- ------------------------------------------------------------------------ -------RKLFF------------------------------------------------------------ -----------------WLVLIFIVTLAS---------KEFF-QM--VH----------------------- GMYSYI-K----------RWENWLQWSV----------------------VLLSSIVLI------------- ------------IP-----------------------------IH-KWQY--------HIA----ALDILLI WIELMTVIG----------------------------------------------RFPIFGL--YIQMFTQV SI-NFFKFLGAYICLIVGF--SLGFSVLH----------------------KN------------------- --YDS-------------------------------------------FNN-P------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------LIA----- ---------------------LLKTIVMMSGELE--FEDIFFS----------------------------- -------S---KSPIL-------------------------Y---SGTAH----LMFLSFVILVTVILANLM MGLAVSDIQELRRCAGLDRLVRRAELV------------------------AHLEHMLFSKLLDYA------ ------P------------------------------------NTIM----------KACRQ---------- --GA-LLL----------------------------HPPHYCT--------------------IHI------ --------------------------RPNDPREKR------------------------------------- -----------------LPQEL-MKAI--------YRL-------------------------VIEK-KNR- ---------------------------------------------------------NMKKKMPIYNTYNIE MDIP---------------------KL----------NRLYS--TTS------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------SD--------------------NNHQQ---------- ---------------------------------------------------------------LNEIIDE-- ------------------------LQ-----------------RC--------------------------- ------------------------------------------FYNISTHLD--------------------- ------------------------------------------------------------------------ -----------ELINKVES----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------I--------------------------------------------------- ----------------------------------------------------------------------VR DCN--------------------------------------------------------------------- ---------------------------NSNT----------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >AmelTRPA5/1-781 ------------------------------------------------------------------------ --MS-------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -AGED------------------------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------------------DRSRLI----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------ASIEN----------------------- ---------------------------------------------------------GDV-E--------TA IRIFT--------------------------------------------------ERFDKKLLK-------- --------------------------------------PVGVLYVTAVQLAAWQGEIELLDLFYRS-GADI- ---NATD-K--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------IGR--------------------------------------------------------- CALFH---------------------AAHRG-----NYEVVNWLLE--------------------HG-AY- ---------TENRVG--------------------------------------------------------- -------------------------------------------------IEACYKKIP-------------- --------------------------------------------GSS--SLNIGRNLPTPECW------GRT AMHQAVKNNH-------------------------------------------------------------- ------P------EVVRMLVN-----------------------------AGA------DA----------- -----------------------------NV-R-----DDRGI-------TPLLLAGSK------------V EREDSN--EISKYNCI--------IEILVSAKVC-INVVH-------------------------------- ------------------------------------------------------------------------ ------PDTGTTAL--------HSAVL---------LGSLLATR---------------------------- ------RLL---------NGGACPLYQCK------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---STGSTPL--------------------------HLAANA----G------------------------N PEILS--------------------------------ILL-E-S---------------------------- --------------------------------------------------------ISSHQIDI-------- ------------------------------------------------RDN-I------------------- --------------------------DRT------------------------------------------- --------------------------------------------------------------------PLHR AS------------------YQGNS---------KCVEILIDHGGNLAA-KTG------------------- -TGVTVIDAI-------------------------------------------------------------- -------------------------------FA--HIP-TPVLLLNDILDSCVKMNC------------NGN SQIIVDFNV--------------------------------------------------------------- LAPKGE-----------------------------------------LQMGVVTSLIAAASSVE-Q-----L TILQHPLVE-----------TFLWLK--------------------------------------WS------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------K------------------- ----------------LRIF-----------------FFTLVFIHALLVLSLSGYS-------------ITI Q--------------------------------------------------YHQT----------------- -D---------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------CT---------------- --------------PLRRILASCSTIILL---------HYTI-QV--LM----------------------- VPKYYL-R----------QLETWLSFAC----------------------SVISFTISMNEDR--------- -------GTEITTS-----------------PG-GEGLNARH-PP-QWVL--------HTI----SLAILVA WMQMMLLIG----------------------------------------------RLPMCGN--YALMFSTV LK-NILKVLLAFVCLIVGF--AFSFAVLF----------------------HG------------------- --NDQ-------------------------------------------FRN-S------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------WRA----- ---------------------VVKTVVMMMGEYE--YGDLFSD----------------------------- -------EK--NGSSF-------------------------L---TATSR----VVFLAFVMLASIVLMNLM IGLAVNDIQGLEKEGHIRQLLKQAEFV------------------------GHLERLTSHRIFRGNWL---- -----HP------------------------------------RLAR------------------------- ------------------------------------------L--------------------LDS------ --------------------------RRGIPTKITFGYHKCYLH--------ESFPG--------------- -----------------IPSRL-REAL--------FLL-------------------------ATEN----- ------------------------------------------------------------------------ ----------------SR-------RF--------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------ESGRENNND--------------------- ------KVE----------------------L---------------------------------------- ---------RTLLEQVLLQ----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------LRMSHTYGIGY----------------------------------------- --------------------------------------------------------------------KFPK HIG--------------------------------------------------------------------- ---------------------------MKSQ---I------------------------------------- ------------------D----------------------------------------------------- -----------------RRKSAI------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >BGIBMGA001085-PA/1-1024 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------MSGGSGG------------------------ --------------------------------------------------------GGSSADGRR------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------PS---------------------------------------------------------------- ----------------------------------------------TCRVDM-------------------- ------------------------------------------------------------------------ --------------GAL-LAS--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------EPRPL---------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------DSKVK------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------RHS---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------IHG---------------------------- --------MTE-------------------------EE---------------------------------- NVVR------------------------PH---------------------------------------QE- ---------MAVLSLE--EK---------------------------------------------------- -------------------------------------KY--LLGVERGDVAGTRRVLQ--RARDT------- ---------------------------------------------G-HINVDCVDP-----------L-GRS ALLMAI------------------------------------------------------------------ --DNENL------EMVELLL-E------------------------------------FGV----------- -----------------------------ET-R-----------------DALLHAIS-------------- ---------EEFVEAV--------EALLDH------------------------------------------ ------------EE---------------------------------------------------------- ------------RT--------RKPGEPN---------SWEALP---------------------------- ------P-------------ETATFTSDI------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------TPL--------------------------ILAAHR----D------------------------S YEIIK--------------------------------LLLDR-G--AQLPEPHDV----------------- ------------------------------------------RC------GCDDCVRS-RREDS-LRHSRSR ---------------------------------------------INAYRALAS------------------ ------------------------------------------------------------------------ PSLIALSSK----------------------------------------------------------DPI-- ------------------------------------------------------------------------ ---LTAFELSWELRRLSA------------------------------------------------------ -----------------------LEHEFKTEYQ--ELRVQCQEFATALLDHTRTSNE--------------- LQILLNH-----------------------------------------EKG--------------------- ASPQA-PL-------------------------------TEPGA----PERMRLSRLKLAIKLR-Q-----K KFVAHPNVQ-----------QLLASI--------------------------------------WY------ ----------------ESVPGFRRKNMLLQAAEMVR--IGAMFPLYSL--AYIAAP---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------HSAVG--------RTLRKPFIKFLCHSASYFMFLFLLILAS--------------QR IETAPG--------------------------------------------GL-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------LWDVSHDEPL----------------------------------------------------- ------SRRGSMPSIVEWLILAWVSGLIW---------SEVK-QL--WDM---------------------- GLREYV-H----------DMWNVIDFVT-------------------NSLYVATVALRIVSHYQVRREMAMG --------LQWNQP-----------------RE-------------KWDAWDPMLLSEGLF----SAANIFS SLKLVYIFS----------------------------------------------VNPHLGP--LQVSLSRM VL-DILKFFVLDILVIFAF--SCGLNQLLWYYADMEKKRCTVGT-ALTP--NGTL----------------- PDPDA------------------------------------C-VVWRR----L------------------- --------------------------------------------FE-------------------------- ------------------------------------------------------------------T----- ---------------------MQTLFWAAFGLVD--LDSFE------------------------------- ---------------LDGI--------------------KIFT--RFWGM----LMFGTYAVINVIVLLNLL IAMMNHSYQLISERADVEWKFARSKLW------------------------ISYFEE--------------- --GGTAP-------PP--------------------FNVLPSPKSLLY-------AWRWLQR-------RLC GHAR----------------A-KR----------EHMRTIR----------------------AIMRNLVR- --------------------------RYVTVQQRR------------------------------------- ------------AESGGVTEDD-VNEIKQDVSAFRCELVEIL------------------------RNSGMN TSTANAGA-------PEVMML-------------RAGGG-------------GGKKNRQKER---------- -------------------------RL------------MKG--FN-----------------IAP----GG SLAPVDEFM---------------------------------SPVSWLQHD------HG-VPHYSLSTLLG- ----------------------------------------PRLRA--------------------------- ----------------------------------SQSSLSDGP---------------GAG----------- ---------------------------------------------------------------MSASRRKPQ ---------------------HKR----------------RWGTI-----------------------IDAA R-AARVSRLI--GR---------------------------SRSEDSVCD---------------------- ------------------------------------------------------------------------ -----------HARQSPSGSEPSES--GSDSQR--------------------------------------- ---------SPERT---------------------------------------------------------- ------------------------------------------------------------------------ ------------------------GSRSGP---L-HPLT--------------------------------- ----ALA------------ALKRKRKKFSDSRR--------------------------------------- ---------------------------------------PEATVRPVPA---------PESLQR-ASSV--- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------VLPVKF-------------------------------------------------------- >BGIBMGA009272-PA/1-1174 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------M--QK---------------------------------------------------- -------------------------------------TF-------------SRRLIE--QNLG-------- --------------------------------------------KPEVLDINCVDP-----------L-NRS ALIAAI------------------------------------------------------------------ --ENENI------ELIKLLL-G------------------------------------SGI----------- -----------------------------KV-K-----------------DALLHAIK-------------- ---------EEYVEAV--------ELLLQW------------------------------------------ ------------EE---------------------------------------------------------- ------------EH--------YEPGEPY---------SWESVD---------------------------- ------S-------------DGATFTPDI------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------TPL--------------------------ILAAHR----N------------------------H YEILK--------------------------------ILLDR-G--ATLPVPHDV----------------- ------------------------------------------KC------GCDECVKS-SQEDS-LRHSQAR ---------------------------------------------INAYRALSS------------------ ------------------------------------------------------------------------ PSLIALSSA----------------------------------------------------------DPL-- ------------------------------------------------------------------------ ---LTAFQLSWELGRLSR------------------------------------------------------ -----------------------METEFRVEYK--ALRQQCQEFATSLLDHTRTSKE--------------- LEIMLNY-----------------------------------------N----------------------- --PWDLDC-------------------------------WEPG------ERQTLGRLKLAIKYK-Q-----K MFVAHPNVQ-----------QLLGAI--------------------------------------WY------ ----------------EGLPGFKRKNIFGQCVQVAK--LGVMFPVYCT--IYMLAP---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------NSEYG--------RFMKKPFVKFICHSSSYMLFLTLLSLAS--------------QR AEYVVL--------------------------------------------EW--S----------------- ---------------------------N-------------------------------------------- ------------------------------------------------------------------------ ------VSWLQELVGYWKD----------------------------------------------------- ------HERGSLPGVIEFAVIIYIASLIW---------AEIR-AL--WTG---------------------- GLTEYI-S----------DLWNIVDFIT-------------------NMFYIAWISLRISSWYIVQRDHHS- GLDP-------WYP-----------------RE-------------RWDSYDPMLLSEGAF----AAGMIFS FLKLVHIFS----------------------------------------------INPYLGP--LQVSLGRM IL-DILKFFFVYMLVLFAF--GCGLNQLMWYYAELEKDKCYHLP-------N-------GLPDFD------- GQERA------------------------------------C-SIWRRYAN-L------------------- --------------------------------------------CE-------------------------- ------------------------------------------------------------------T----- ---------------------SQSLFWASFGLVD--LTTFE------------------------------- ---------------LTGI--------------------KSFT--RFWAL----LTFGSYSVINIIVLLNML IAMMSNSYQIISERADTEWKFARSNLW------------------------MSYFED--------------- --GDTVP-------PP--------------------FNIIPTPKHFF----------------------CWI KSYF----------------N------------KRERRSILNK----------SREKARQEHEAVMRILVR- --------------------------RYVTAEQRA------------------------------------- ------------RDEVGVTEDD-VMEIRQDISTLRYELIDIL------------------------HNNGMK TPRVSL-----------------------------QDTAV-----------S-GKKGKVMER---------- -------------------------RI------------LKD--FQ-----------------IGIVEG--- ------------------------------------------------------------IIKDVI------ ------------------------------------------------------------------SK---- ----------------------------------ENKPKDVFS--------------QIAK----------- ---------------------------------------------------------------AIVRRSSTD --------------------SKKR----------------DWNAL--------------------------V R-TNTVRRDPI-GT---------------------------AAEAEIRRSRQS------------------- ------------------------------------------------------------------------ -----------LRAHILE-NVQ-SR--TIDPQK--------------------------------------- ---------LLQYN---------PK-LSEL------TPTTRVAYAK------FMRSKLRSDF---------- -------------------------------SAKERNKRKSDESSLD---------GEDF------------ ---------------NDEVLEAPQRHDQK------RPVRS-----FRS-----------RTPIPE------- --------------MSDDEGLRENEITIEVDVEDQDTDSIKTKPLKIYSGDHTEPNTPSMDGNYHHFPSPES QDHVIQIEPDTPTKNLLLMKEEERNLQDP-----TAKSPSLKQNEQILS---------ASALESQYTQASSS RTS--------------------------------------------------------------------- --------------------------ITKGGT--EKLPYKSCL----------KY--------TNDT----- ---------------P-KNVES-AIPSTSRL-------SRKDSK---------------------------L V----------SASLQSQMAPSRFSQS-------NVTKSPD------------------------------- --------------------------------------------------KSLASSKT-------------- ----------------------------------------------SSPKSLS--P---------------- ------------------------------------------------------------------------ ----------RSPRVVPSSPTPSI--------------------MSAGKGKSKA----TGRIVSGWL----- >BGIBMGA009273-PA/1-603 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------MAEKKDL-EAG--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------DPE---------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------LECV------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------RKP---------------- ------------------------------------------------------------------------ ---------------------MPLPVLP-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------KPLTLE--EK---------------------------------------------------- -------------------------------------KY--LLAVERGDMANVRRLLQ--KGHR-------- ---------------------------------------------KKHIDINCVDS-----------L-GRG ALTLSI------------------------------------------------------------------ --DGENL------EMVELLV-I------------------------------------MGV----------- -----------------------------ET-R-----------------DALLQAIN-------------- ---------AEFVEAV--------ELLLEH------------------------------------------ ------------EE---------------------------------------------------------- ------------LI--------HKDGEPY---------SWQKVD---------------------------- ------P-------------NTAMFTPDI------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------TPL--------------------------MLAAHK----N------------------------N YEIIK--------------------------------ILLDR-G--ATLPNPHDV----------------- ------------------------------------------RC------GCEDCIRQ-STEDS-LRHSLAR ---------------------------------------------LNEYRALAS------------------ ------------------------------------------------------------------------ PSLIALSST----------------------------------------------------------DPI-- ------------------------------------------------------------------------ ---LTAFELSWELRNLAF------------------------------------------------------ -----------------------AEQESKAEYL--ELRRQAQLFAVDLLDQSRSSQE--------------- LAIILNH-----------------------------------------D----------------------- --PDE-PA-------------------------------FVDG------EHMKLARLELAIDFK-Q-----K KFVAHPNIQ-----------QLLASI--------------------------------------WY------ ----------------EGVPGFRRKTTMEKIMIICR--VALLFPFYCT--LYMIAP---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------NCATG--------KLMRKPFMKFLIHASSYLFFLLILILVS--------------QR AEVQAI--------------------------------------------QL--F----------------- ---------------------------G-------------------------------------------- ------------------------------------------------------------------------ ------PEWMVKELEKELL----------------------------------------------------- ------KQRGNGPTYLELVVVVYVLGFIW---------EETQ-EI--YIE---------------------- GIRSYL-R----------NMWNFIDFTR-------------------NSLYVAVALLRFAAYLQQAAEIRRD QQTK-------FIP-----------------RE-------------SWDAFDPQLIAEGLF----AAANIFS ALKLVHLFS----------------------------------------------INPHLGP--LQISLGRM VI-DIVKFFFIYSLVLFAF--ACGLNQLLWYFADLEKKKCYVLP--------------GGLPDWD------- NAGDS------------------------------------C-MKWRSFGK--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >BmIav/1-999 ------------------------------------------------------------------------ --MGNAIGKF-------------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------------------LTA------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------GNVQGA------ ------------------------------------------------------------------------ ----------------------------------------------------------------GSVL---- DRVISQPS---------------------------------------------------------------- ---------------------------------------------SEDHTVLYKLA---------------- ------------------------DYKKGGLLLET------------------------------------- --------YAKGGM---------------------------------------------------------- ------TAAEKL------------------------------------------------------------ ------------------------------------------MRDEFAAY---------------------- --------------------------------MYGG---------------------GRG-R-----VINRA EYLRWKFRD--------------------------------------QEQVVLPIE---------------- --------------------------------------------------------------------ASL- ---SPYDPL--------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------AK----------------- --------------------------------------------WED------------------------- -------------------------------------------------------------HT--------- ----------------------------------------ACWQ---------------------------- ---------MCYRGALG-------------------E----------------------------------- SLLHV-------------------------------------LIIC-------------------------- ------------------------------------------------------------------------ -----------------------------------DTKI--HTR-------LARTLVK-------------- ---CF---------------------------------------PKLSLDVVEGEEYL-----------GAS SLHLAI------------------------------------------------------------------ --AYSN------NELVQDLVE-----------------------------AGA------DVNQRAIGSFFLP RDQQRVPP-------------------ARQ--T-----NYEGLAY--LGEYPLAWTAC-------------- ---------CANEAVY--------NLLLDS-GAD-------------------------------------- ------------PD---------------------------------------------------------- ----AQDSFGNMIL--------HMVVV---------CDKLDMFG---------------------------- ------YALR------HPKVPASNGRMN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---KAGFTPL--------------------------TLACQL----G------------------------R ASVFR--------------------------------EMLEL---------SARE-------FWRY------ --------------------------------------SNITCSA--------------------------- -------------------------------------------YPLNALDTLLP------------------ -------------------------DGRT------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -NWNSALFII-------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ LNGTKQE----------------------------------------------------------H-----L NMLDGGIIQ-----------RLLEEK--------------------------------------WK------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------T------------------- ---------------FARTK-----------------FLKRLLILMLHLLLLSVSV-------------YLR HS---------------------------------------------------------------------- ----S----------------------A---EADAH------------------------------------ ------------------------------------------------------------------------ ------PN----------------------------------------------------------WGLE-- -----------INDARSGLRLASELGTIL---------STLC-YI-ILQQ--------GDE-------LKNQ GLVAYF-K----------QLIHEPAKFI----------------------FLASNILVLACIPARLL----- -----------------------------KETN--------------VEE--------AIL----LFLLPGS WFLLMFFAG----------------------------------------------AVKLTGP-FVTMIYSMI TG-DMFTFGIIYCIVLFGF--SQSFYFLY----------------------RGF------------------ PNVQS-----------------------------------------TLYSS-Y------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------PST----- ---------------------WMALFQITLGDYS--YSDLSQT----------------------------- ----------------------------------------TY---PNLSK----TVFTVFMIFVPILLLNML IAMMGNTYAHVIEQSEKEWVKQWAKIV------------------------VSLERSVAQDDAHKYLQ---- --EYSIGLGPSDD------------------------PRYEQRAVMVI---------KSKAK---------- -TRA----------------KQKKDA----------LTNWKHV------------------GKVTIAELRRR GISGEELRRLMWG-RISIS-------TPTKAPLPRRVPAPPPDCVVSSDVGLASDVG--------------- ---------------NGVAPAL-SSALNV-MAFT-HELDIGTTGS----------DQKQTTPDLLVNGKTSN A-PILTTGTQMPK----------------V----SSKTLGTPVARIEASSLKTPLDVKLNPTTLTQSTVQGN IGNVNIPISGVKITTNVGQNSAVVPEI---QQSNENQKPEQV--HQDYLR-----------ELIVLAEK--- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------PATTNLE--------------------------------- ---------------------------------------------------------------LKQLAEK-- --------------AADLRDVPEIDI---------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------NINMA------------------------------------------------ ------------------------------------------------------------------AKSARK MVAGAV-----------------------SGLFGVAADTPAP------------------------------ --------------------------------------------------------DAGWRRDRHDN-SDSD ---------------P-------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------ISGTI-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ >BmNan/1-813 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------MIGGGLLVDM------------------------------------- --------MKRALQNK-------------------------------------------------------- ----QYAEIDHA------------------------------------------------------------ ------------------------------------------IKTKVEPF---------------------- --------------------------------LYNR---------------------GRG-R-----YIPIS HLVLLRNKER-------------------------------------PRHKLLPPL---------------- --------------------------------------------------------------------RGM- ---ENPD----------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------EE----------------- --------------------------------------------FDV-DKD-----------WPVVTQEEYD A--------------------------------NPSGY-----------------------RE--------- ----------------------------------------LCWD---------------------------- ---------VKERGAVG-------------------E----------------------------------- TILHL-------------------------------------CLLN-------------------------- ------------------------------------------------------------------------ -----------------------------------ATSL--LAH-------LAKRLLR-------------- ---FY---------------------------------------PKMINDIYISDEYY-----------GET VLHITI------------------------------------------------------------------ --VNED------PTMAKFLLD-----------------------------AGA------DYHERCYGNFMCP EDQKASRTDS---------FDHEWVNVQPD--T-----NYNGYVY--WGEYPLSFAAC-------------- ---------LGQEECY--------RLILAR-GAD-------------------------------------- ------------PD---------------------------------------------------------- ----KQDTNGNTVL--------HMLVI---------YEKMSTFD---------------------------- ------MAY---------EVGASLNIRN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---VQNLTPL--------------------------TLAAKL----A------------------------R TEMFF--------------------------------HILNI---------EREI-------YWQI------ --------------------------------------GATTCAA--------------------------- -------------------------------------------YPLGQVDTIDT------------------ ------------------------ETGLI------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -SKDSALNLV-------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ VFGEKDE----------------------------------------------------------H-----L GLLEG-MLI-----------DLLKTK--------------------------------------WN------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------T------------------- ---------------FVKFR-----------------FYRQFILFSCYFLVSLICF-------------TLR PG---P-------------PDR-----ALNTTVLN---------------------STI------GPNVT-- -DAEL-----------VSDV-------E---NCTM---------TPNADFDTNAVEVLNGTK---------- ------------------------------------------------FGGSHC------------------ ARFKSHPKEKSTEAPREND-------------------VEGWWEDLTEE--CRLMN-------LDTWQAK-- ------------------LRISAELLLWM---------GALA-YF--GAA--------LRE-------AKFL GIKMFI-E----------NLSTVPSRVM----------------------FLFSCLLMLILPTLRLW----- -----------------------------CADE--------------AED--------HLA----VMIMLTT APYFLFFCR----------------------------------------------GFKTVGP-FVVMIYRMV MG-DLLRFVCIYLVFVMGF--SQAYYVIF----------------------LSF------------------ DNPNT------------PEGVDDS--------------------VSNPMPS-P------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------MES----- ---------------------IMAMFLMSLTSFSDYYTAFDRT----------------------------- ----------------------------------------DH---EIEAK----LLFVIYMIIVAILLVNML IAMMGNTYQK-IAETRNEWQRQWARIV------------------------LVVERGVPPAQRLKQLM---- --TYSQPMANGKR-----------------------------ALVLRI---------NQK-D---------- -EDK----------------EEMKEI-----------LEMKRT------------------HERIVAKRKQR ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------------EALKP GEI--------------------------------------------------------------------- ---------------------------PPPAR--D------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------YPIRK-------------------------------------------------------- >BmNompC/1-2086 ------------------------------------------------------------------------ --MSDS------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------G------------------------ --------------------------------------------------RD-------------------- -------------------------------------------------------------VP--------- ----------------------------------------------RSANIN----------FSSGVRS--- --------P-----PANQQ-------------KDLQRLELS------------------------------- --FIELNKE--------------------------------------------------------------- ---RAKQKEWKKLIRDLVF-------------QRGKVPLLLAVEAGNQS-MVREL--L-------------- -------------------------SAQTAEQLK-----------AT-TPAGDTA----------------- --------LHLAAR---------RRDVDMARILVDYGA---------------------------------- ----VVDATNGA---------------------------------------------------GQTPLHIAA ---------------------------------AEGDEP--------------------------------- -----LVKYFYGVR----ANAAIADNEDRTP-MHLA-AEN-----------------GHA-A--------II ELLADKFK-A--------------------------------SIFERTKDG--------------------- --------------------------------------------STLMHIASLNGHADCAMMLFKK-GVYL- ---HMPNKYFEKQTFDEVLFVKIENGLIKGLKSDDGSYSMFLGIPYALVNESNPFGDSLPTLPFNEIYEAFD DSTACPQKEEFNNTIVGEMQCLRLNIYVPKSLNNNLPVLIYFYGGTFEIGFAGRYLYGPKYLVRHEIILVTV NYRLGPYGFLCTDSSNAIGFKTAQLDLAIDFLSKENYKDVINAAVELDVKFYCCNENYFSGAQNFLTDYPIN LNTPIVEGMSILIGNTNNERAHNYYGKKNLNFDIFQDHLQIAFNFDD-EHLLNTKEIVKKQYIGNEKNIDMV ENNIVQFSSDFYYYHPTKRNVLKYIDNG---AKKVYNYLFSYDGNRNFLKKTFNLNGSGAFHADEIGYLFDI SFMDKTLTIEDMLIVDRITTLWANFVKSGNPTPVPTELLPIIWKPISKDSFYTLNIDTAMELKSGFFEDRMI FWDTFFEKYKHFDGA--------------------------------------------------------- RSIHT---------------------AARYG-----HVGIINTLLQ--------------------KG-ES- ---------VDVTTN---DNYTAL---------HIAVESCKPAVVETLLGYGADVHIRGGKQRETPLHIAAR IPD--GDKCALMLLKSGAGPNKATEDG--------MTPV--HVAAKFGNLATLVLLLE-----DGGDPLRKT KVCIYDVVTGETPLQMACRSCMP---DIVRHLIEFVKDHKGESVSTA--FIDAVDE-----------D-GAS ALHYACKVTK-------------------------------------------------------EEVK--- -IPTADR------QVVKCLIE-----------------------------NGA------DVSLQTRHNHETA FHYCAIAGNNDVMTEMIAHISTADVSRALNR-Q-----NSIGW-------TPLLIACH-------------- ---------RGHMQLV--------NTLLTN-HAR-VDVFDVEGRSALHLAAEHGYLQVCDALLTN------- --------------------------------------------KAFIN----------------------- ----SKARNGRTAL--------HLAAM---------NGYAHLVKFLIRDHNAMIDVLTLKKQTPLHLAAASG QIEVCKLLL---------ELGANIDATDELGQKPIHAAAQNNYSEVVQLFLQ---QHPNLVMATTKDGNTCA HIAAIQGSVKVIEELMKFDRTGVISARNKLNDSTPLQLAAEGGHADVVRVLVRAGASCTDENRAGLTAVHLA AEHGHTNVLDV-MR--STNTLRISSKKLGLTPLHIAAYYGQAETVRELLSHVPGTVKSEAPT---GVSLVPV LGAESGLTPL--------------------------HLAAYN----G------------------------N ENVVR--------------------------------LLLNSAG--VQADAASNE-------NGY------- --------------------------------------NPLHLAC------------FGGHMSI-VGLLLSR SAE-----------------------------------------LLHSTDR-H------------------- --------------------------GKT------------------------------------------- --------------------------------------------------------------------GLHI AST------------------HGHY---------QMVEVLLGQGAEINA-TDK------------------- -NGWTPLHCA---AKAG---------------------------------------HLNVVKLLCESGASPK SETNLNCAPIWFAASENHN------DVLEYLLH--KE----HDTQSLMDDK--------------------- ---RFVYNL------------MVCS----KNHNNIPIEEFVLVSPAPVDTA-AKLSNIYINLSTKEKERAKD LIAAGKQC-----------------EAMATELLALAAGADSAGHILTATDNRNIEFLDVLIENE-Q-----K EVIAHTVVQ-----------RYLQEL--------------------------------------WR------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------G------------------- ---------------SLKWT-----------------GIKIMFLFFAFIVCPPVWM-------------VFS L----------------------------------------------------------------------- --------------PLGHRY-------H---KI--------------------------------------- ------------------------------------------------------------------------ ----------------------------------------------------PIIKFM-------------- -----------SYLTAHIYLMVLLALVAI---------TPIYNSI--FRD---------S------------ -------L----------IP-RWYEWMLLISLSGLLLLELTNPSDKSGLGWIKIAVLLLGMIGVATHVVGWI ----------FI-------------------------QPKYWPTLMYCRN--------QCF----ALSFLLA CVQILDFLS----------------------------------------------FHHLFGP--WAIIIGDL MK-DLGRFLAVLAIFVFGF--SMHIVAL-------------------------------------------- --NQP-------------------------------------------FRN-INKSEDNKYASQARRKLFSD ENQRNKRQAFVPQWIK--PLSGESYR---RKQGPAGPTLTPIEAFEKLFFALFG--------QITLSDLNYI SNLRPSWTSNLFK------------------FVFGAYLLMS--------VVVLITLLIA-----MMS----- -----DTYQRI--------------------QLL--FFAVF------------------GQTT--------- ------TEQ-TKVHS---------------------KDSNIQ---PAWTNYLFKIVFGIYMLVSVVVLINLL IAMMSDTYQRIQAQS-------------------------------------DIEWKY-------------- ------GL-----------------------------------SKLI----------RNMHR---------- --TN-----------------------------------------------------------TAP------ --------------------------SPLNL----------------------------------------- -----------------VTTWL-MWLIAR------CRERL-----------------------TKKK----- -------------------------------RPSLVHM-----------IG-LQRQDQLSAR---------- --------------------------------SKAGAKWLSK--VKR------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------GQ----------------------------------- ------------------------------------------------------------------VVPK-- ---------------------DSTRL-----------------SV--------------------VHLSP-- ---------------------------------------------LGSQLSF-------------NNATRIE NVVD------------------------WEII---------------------------------------- ---------AKKYRALMRD----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------EPEE------------------------------------------------ ------------------------------------------------------------------------ STA--------------------------------------------------------------------- ---------------------------KESET--DS-----------------------------------S ---------------D-EVSEIIP------------------------------------------------ -------------NN----IAAAPP----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >BmPain/1-943 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------MSRDNYEMK---------------- ---------------------------------------------PKQLSRNSSLF---------------- ------------------------------------------------------------------------ ---------------------------------------------------------------GTDPQ---- ------------------------------------------------EL---------------------- --------------------------------LNKA-LQN-----------------NDY-A-------KFK KLVTEA------------------------------------NVDLE------------------------- ------------------------------------------------H-------------VYEY------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------PDYK--------------------------------------------------------- TCLEV---------------------AVSDRN----KLEFVKLLLQ--------------------YQ-VE- ---------VN--KVN-VTHS--------------------------------------------------- -----------------------------------AAPI--HFAVENGNIDALAALLE-------------- --------------------------------------------DDRI-DVNV-KS-----------R-GNT AILMAVKQIE-------------------------------------------------------EL-D--- -DAREHELTIYE-DMIELLLK-----------------------------AGC------NA----------- -----------------------------NS-P-----DLKGV-------TPIYSAAK-------------- ---------QGLERVI--------TLIIDY-AKHAIDIDTYK----------DRRGKTARDYLKEAFPYLEA KFDST----TQDPE-----------IVDSDKLFSYLSRHEEDNFIRDF--LKLANKNEHR------------ -KILPVNNGMNTML--------QLATE---------KGFEKAVS---------------------------- ------TLL---------RYGADPNATC-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --SSNTSRPI--------------------------ALACQN----G------------------------Y YKIVK--------------------------------MF-------------MDN-------EST------- ---L-------------------------FDPVNS--ESLVQITIKGRR-SSINI-PNVNFDEC-LRLLLN- ----------------------------------------HPKMDIN-VNH-MD------------------ ------------------------MKNNT------------------------------------------- --------------------------------------------------------------------ALHY AAR------------------NGDN---------KTVLELLRNGACIGL-RNS------------------- -FDEPPLADIN------------------------------------------------------------- -----------------------------------------AKTLEAFLDECVTTNN--------ERPSNDD YEIHMKYSF--------------------------------------------------------------- LVYPNNS------------------LENELCKVPLIDNTNNNVKEYDTILAPETDALLYMTRNE-E----LR PLLKHPVIT-----------SFLYLK--------------------------------------WQ------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------R------------------- ----------------ISCL-----------------FFANITFYSFLWLCLILYI-------------ILG YG------------------------------------------------A-EKK----------------- -Q-RD----------SFEAL-------N--VIT-------------HVG----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------VIIGVVLLL-----I---------RELF-QL--LL----------------------- SPTRYL-Q----------SIENWMEIGL----------------------IFVTIWIVFSKSA--------- -------------------------------TE-------------STKQ--------QLS----AVAILLS SAELVLLIG----------------------------------------------QFPTLST--NIVMLKTV SW-NFFKFLLWYCILIIAF--ALSFYTLF----------------------RQENEEDQRAPDPNTVGKEE- EEEDF-------------------------------------------FED-P------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------GRS----- ---------------------LFKTIVMLTGEFD--ASSIKFS----------------------------- ----------------------------------------TY---PLTSH----IIFIVFVFMIPIVLFNLL NGLAVSDTQEIRADAELVGHISRIKLI------------------------SYIESVLIGSAKTHSRPSKC- --WSLLPFN-----------IQNLNLIKP-------------KTFFT----------KSFAK---------- --RICLFPHF-----------------------------------------------LPK-YKILV------ --------------------------KPNQNNIIEIPHADDKDLERSGG----------------------- -------CCFERCQNYRLDRKI-VKNAKL---------------------------------VISNK----- ------------------------------------------------------------------------ -------------------------------------TKITE--FD-------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------DKLSM---------------------------------- ------------------------------------------------------------------YENK-- -----------------IESLEATLK-----------------KV--------------------------- ------------------------------------------LLAIESQRN--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >BmPyr/1-746 ------------------------------------------------------------------------ --MS-------------------------------------------------------------------- ------------------------------------------------------------------------ --QLQE------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ DAEDD----------VEGG----------------------------------------------------- --YIS--SDESAHGA--------------------------------------------------------- ----------------------------------------------DLAER--------------------- ---------------------------------------------------LRV------------------ ----------KPSK---------------------------------------------------------- ------------------------------------------------------------------------ -DIWELDEI----------------------------------QYTL------------------------- ---------------------RLLP--------------------------------YSE-E--------IS VLIGN---------GNY-----------------------------DETIQFAS-E-AEGGF---------- ------------------------------------------GLRTAILWACWLGKSILLFKLLKM-GVDP- ---DELD-D--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------AGR--------------------------------------------------------- TCLHL---------------------SCLVG-----SEECVKLLLD--------------------HG-AH- ---------PNTWDSS-TETK--------------------------------------------------- -----------------------------------ATPL--HCAASAKSLACVKVLIA-------------- --------------------------------------------HGA--DVNAGLS-------------DRS PLHYAVLSDA-------------------------------------------------------------- ------P------EVVKELLE-----------------------------AGA------CP----------- -----------------------------DT-P-----QVFTE-------TPLHVAAS-------------- ---------LGSASCT--------KLLLNA-GAD-VRAAM-------------------------------- ------------------------------------------------------------------------ ------GPGKATAL--------HLAAE---------DGHAECAR---------------------------- ------LLL---------DHGAHIDWPN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---FRGQTPL--------------------------HLATLA----Q------------------------S LEVVE--------------------------------MLVDR-C--ADVR-AKDA-------DGR------- --------------------------------------TPLHGAIVR----------GARACDI-ARLLLSA GAD------------------------------------------PNAADN-F------------------- --------------------------GYT------------------------------------------- --------------------------------------------------------------------PLHI AA------------------LNEFS---------ACVLLLLDYGGDVTL-RTN------------------- -GGVSALSFI-------------------------------------------------------------- -------------------------------VR--RVP-DVIPRYLCKFDDAVHVSEH--------ELGDVD CELTIDFRP--------------------------------------------------------------- LVPC--------------------------------------------LTRGEAELLLAFVEI--------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------P----------YWD--------------------------------------------------- ----------------------------------VDNGVLRTNTT-NWQH--------DVA----AITIFFC WLELMMIIG----------------------------------------------RFPTFGL--YVQMFTTV TV-NFATFLLAYSCLLIAF--GLAFSVLF----------------------SN------------------- --YPA-------------------------------------------FHL-P------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------A-G----- ---------------------LVKTVMMMSGELE--YEDIFYN----------------------------- -------NC-TNSEIY-------------------------Y---PLTAH----IMFLIFVLLVTVILTNLL VGLAVSDIQALQEGAGLDRL---------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------IPKEF-ISAI--------YKM-------------------------VASR-KNTK RSVRK---------------------------NNNYEFRIRRCP----EEETISKPEIVKRKSNLYDRFSFD SQQVE--------------------RR----------KRPTS--GSN------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------TD--------------------SRNRP---------- ---------------------------------------------------------------PSLTINA-- ------------------------IQ-----------------EI--------------------C-----M V---------------------------------------DIKTQLLELTK--------------------- ------------------------------------------------------------------------ -----------KVNKLLEG----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------T--------------------------------------------------- ----------------------------------------------------------------------EA RLN--------------------------------------------------------------------- ---------------------------QIES----------------------------------------- ------------------------------------------------------------------------ -----------------KVNGPLP------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >BmTRPA1/1-1171 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------STYIH----------- ------LSTSTKV---------------------NLSFFVQAAESGNVD-DFMRL----------------- -------------------------YLSEPSRLA-----------VR-DGRGRTA----------------- --------AHQASA---------RNNTNILHFINNYAG---------------------------------- ----DLNAKDNA---------------------------------------------------GNTPLHVAV ------------------------------------------ENEALD------------------------ -----AIEYLLQQH----VETSVLNEKCQAP-IHMA-TEL-----------------NKV-S--------VL QVFAKYKSLF--------------------------------NVNQGGEHG--------------------- --------------------------------------------RTALHFAAIHDHDLCAKILITD--LDA- ---EWKKP---------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------CN----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------NGY--------------------------------------------------------- YPIHE---------------------AAKNA-----SSRTIEVFLQ--------------------WG-EQR GC--TREQMISLYDN---EGNVPL---------HSAVHGGDIKAVE-------------------------- -----------LCLRSGAKISTQQHDL--------STPV--HLACAQGALDIVKLMFT-------------- ------MQPKEKHACLTSCDVQK-----------------------------------------------MT PIHCAAMFDH-------------------------------------------------------------- ------P------EIVNYLIN-----------------------------EGS------DI----------- -----------------------------NP-L-----DKERR-------SPLLLAAS-------------- ---------RAGWRTV--------HTLIRL-GAD-IQLKDINSRNVLHLVVMNGG--RLEDFA--------- ---------------------------------ASCKDHCEKSLLQLLN----------------------- ----EKDNTGCSPL--------HYASR---------EGHIRSLE---------------------------- ------NLI---------RLGACINLKNNNNESP-------------------------------------- ------------------------------------------------------------------------ --------------------------------LHFAARYGRFHTACQLLDS-------------DKGTFIIN ESDGEGLTPL--------------------------HIASRE----G------------------------H TRVVH--------------------------------LLLNR-G--ALL--HRDH-------NGR------- --------------------------------------NPLHLAA------------MSGYTKT-IELLHSV HSH-----------------------------------------LLDQIDK-D------------------- --------------------------GNT------------------------------------------- --------------------------------------------------------------------SLHL ATM------------------ENKP---------SSIALLLSMGCRLSY--NN------------------- -MDMSAIDYA---IYYK---------------------------------------FPEAALAMVTHEQRAK --------EVMALRSDRHP------CVTLALIA--YM----PRVFEAVQDKCITKANC--------KKDSKS FYIKYSFEA------------L-CPQL----MDEDGTRKSQQAQQIPLPALNIKYSFKYYQKSKHEIEALRL AHNDPK------------------------------------------YRPEPLSVINAMVAHG-R-----V ELLAHPLSQ-----------KYLQMK--------------------------------------WN------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------S------------------- ---------------YGKYF-----------------HLVNVLFYCIFLIFVTVYS-------------YLL M----------------------------------------------EHVNPIN------------------ ------------KRERSRVG-------D---VY--------------------------------------- ------------------------------------------------------------------------ YNY-TATNRTQTNWD-----------------------IDADFE--------AIL----------------- -----------IMYTSSVVIMVYISVCMM---------REAY-NL--KQ----------------------- QKWHYI-V----------DPSNLVSWTL----------------------YISATITVFPTLY--------- ------------------------------------------GHYSNYQF--------SAA----SITVFLS WFELLLLLQ----------------------------------------------RFDQVGI--YVVMFLEI LQ-TLIKVLMVFSILIIAF--GLAFYILL----------------------SKV------------GSVEM- GNHLS-------------------------------------------FSN-I------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------PIA----- ---------------------LMRTFAMMLGELD--FVGTYVQPYYK------------------------- -------DD-SD-IIL------------------------PF---PIPTF----IILALFMILMPILLMNLL IGLAVGDIESVRRNAQLKRLAMQVVLH------------------------TELERKL-------------- ------P------------------------------------AFLL----------EKVDK---------- --LE-----------------------------------------------------------LIE------ --------------------------YPNNKKCK-------------------------------------- ------------------LGFL-DLILHK------W-FCNP------------------------------- ----------------------------------------------------FTEDTGLD------------ -------------------------------------LVLEN--NDD------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------YVTEQ----------------------------------- ------------------------------------------------------------------MEKQ-- ---------------------KRKFR-----------------EM--------------------QNV---- ---------------------------------------------LDQQYLL-------------------- ------------------------------------------------------------------------ ------------LRLIVQK----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------MEIK------------------------------------------------ --------------------------------------------------------------------TEAD DVD--------------------------------------------------------------------- ---------------------------EGVSP--NDTKVV-------------------------------P ---------------R-WSSHRNR------------------------------------------------ -------------KKLHSARAASFNKS--------------------------------------------- ----------------------------------------------------T------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >BmTRPM/1-1384 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------MALLLP---------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------ITVFRI----------------------------QERAEGGEVQEL----------- -----------------------------DQ-V-I--------------LTALFRAQH-------------- ---------LTPSE----------QLSL-------------------------------------------- ------------------------------------------------------------------------ ------------AL------------------------TWNRVD---------------------------- ------IA------------RSEIFVYGQEWP---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------PGAL----------------------DEAMMQALEH----D------------------------R IDFVK--------------------------------LLLEN-G--VSMRKFLTI--------PRL------ --------------------------------------EELYNT-------------KSGPSNT-LRYILRD --------------------VRP-HLPKGYVYTLHDIGLVINKLIGGAYRCYYT-----------RRKFRPI YAKVMNKSV------------NVHRNSAS----------------------FTRHNAG-------------- --GLSLI-----------------------------------TGFMPVTSEMAL----------FD-YPFNE LLMWAV--------------LTKRH---------QMALLMWTHGEESLA----------------------- -KSLIACKLYKAMAHEAAED---------------------------------------------------- ----------------------DMETEVYEELR--HYGKEFENKALELLDYCYRQDDD-------------Q AQQLLTCELQ-------------------------------------------------------------- -------------------------------------------------NWSGQTCLSLAVTAN-H-----R ALLAHPCSQ-----------IILADL--------------------------------------WM------ ----------------GGLR--TRKNTNLKVI------LSLLCPLYIL--RLEFK----------------- -SKEELQLMPQTEEEHL-----------------------------ENESIE-------------------- -----DDRS-----------------------------TKDPTDAEALIGSGECE----------------- TRVDQNGKVG---------------------KVGWEPSYRELPEY------------------HPSEIKRMR PLRLR-----------KKIY--------EFFTAPITKFWADSIAYILFLLMFTYTV-------------LVK MNP--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------TPSWPEIYSICYILTFLC---------EKIR-EI--VTS----EPV-----------AIRH KFSVWA-W----------NMWNTYDAGF-------------------IIFFLVGLTLRLR------------ -------------------------------------------------EIS-RDVGRVIY----CVDIIYW YLRILNILG----------------------------------------------VNKYLGP--LVTMMGKM VK-NMIYFVVLLLVVLMSF--GVARQAILHPD-------------------KD------------------- -------------------------------------------ASWHLIREVF------------------- --------------------------------------------FQ-----------------------PYF MLYGEVFAEQMAPPCGLPGLEECRVGHWVPPLVMSVYLLIANILLVNLLIAVFNNIFIEVNGVSHQV----- ---------------------FYQPYFMLYGEVF--AGDID---------------PPCGK----------- -------EIGDRK-CVTGR---------------------------WITP----IAMTVYLLIANILLINLL IAVFNNIFNEVNEVSHQVWMFQRFTVV------------------------MEYEQK--------------- ---PVLP-------PP--------------------LIIFCHIYAVGK----------WVTR---------- --NV----------------SHKR---------FQYDNGLKLFLEK------EDMERLYDFEEECVEGYFR- -------------------------EQEIKLSNSI------------------------------------- ------------EERVRNTTDR-VEHITTKMEDLNQKANCQIQ----------------SMQSVEFRLRKLE DIAEQTMSHLAVIHRFMATHPS---------LVNRGSTDTLG------PPPPSFQAGGNRLRTASDRSE--- --------------------------V------------LSD--SDTG--ARF---------AVRPVQ---- -----------------------------------------------EEDEQP-------SCHSDVSH---- ---------------------------------------SDTLKLRDR--------------CLNNRSFKS- -------------------------------RLWKRERERERE-------------RERER----------- ----------------------------------------------------------------ERERESER ---------------ERA-RERERER---ERER----ESERERARE------------------------RE RERES------------------------------------RERERERRSEGGNDCG--------------- ----------------------------------------------------MGPYS--------------- ------SQHLAPRRQHSQT-HSEPD--NSAVDAG-------------------------------------- --------------------------SVHNSV-T-GPQSGWEGAGATGAAGGTGRARVG------------- ------------------------------------------------------------------------ ----------------------------------GAP----------------------RSLLLA------- -------------MH-EYTSITDE---------------------------------------------LET VY-GLFSPPHTPRTPI------TSRLLSPARA--ASPSVRRRHASEMSNP------EFALFMEK----EHLR GAEEDDYIIMENLIQRRL------------EMGSVLDRYEEEEGGEGAGAGGAISISVCVNTSEEQPQSSSL LTV--------TDRRLPH--QRHS--LRRS-----SAVDSREL----------PS----------------- ---------------P-LQPLL--------------------------------GDD--------ACCE--- -----------VLLPVPRQPSGDTNASS-----------------------DLSL----------------- --------------------------------------------------SHMVSENL-------------- --------------------------------------------------PPRPSIVLDSS----------- ------------------------------------------------------------------------ ----------QLPRQ---------------------------RSAEQQQ-TQPPGPSRPETMC--------- >BmTRPML/1-596 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------MHAPDDT-- ------------------------------------------------------------------------ --------------------------------TCSE---------------------GED-D---------- --------------------------------------HKKE------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------IR--------------------------------- PNANN---------------------EQ---D---------------------------------------- -------------------------------FPHQST-SFSPPTQM-------------------------- -------------------------------------------------EEKMRRKLQ-------------- ---FF--------------------------------------------FMNPIEKWK---------AKRKF PYKFVV------------------------------------------------------------------ -------------QVIKIVLV--------------------------------------------------- --------------------------------T-F---------------QLCLFAHNR------------- ---------YNHVNYTWDNRITFSHLFLLGWDST-------------------------------------- ------------RE---------------------------------------------------------- -INAYPPGAGPLAL-------------------YKIDEFYNTLD---------------------------- ------YAVAGYTNLSN-AIGPYSY----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ NDENNFMPDPVFCQYNYKQG----------------IIYGFN----E---------------SYQFN----S -EVFETC--------INFT------IKDNEDFKSEA-YIRDA-G--LNI----SF----------------- --------------------------------------SSLVRAK--------------------LMFSIKT INFRA-------------------------------------AGPITPPDC--------------------- ------------------------------------------------------------------------ -------------------------------------------------------------------YRFDV EII-----------------FDNED----------------------------------------------- HDGQMSLFLE-------------------------------------------------------------- -------------------------------------------AEPHKLE-CKGDTAYVT-----DNKIDQI LRSTLNILVI-------------------------------------------------------------- -------------------LICAA-----------------------------------------SFVLCSR ALYRAQLLKELTV-------QFFRRQYDRDLSLDGRLEFLNI----------------------WY------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------IMIIINDLLIIM---G-----SAIKEQI--------------------------- ERNQFT-N----------DQWNVCSLFL-------------------------------------------- -----------------------------------------------------------------GTGNLLV WFGVLRYLG----------------------------------------------FFKTYNV--VILTLKKA AP-KIFRFSICALLLYAGF--MFCGWLILGPYH--------------------------------------- --------------------------MK--------------------FRS-L------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------ATT----- ---------------------SECLFSLINGDDM--FATFSIMSK-K------------------------- ---------------------------------------SPML--WWFSR----VYLYSFISLYIYVVLSLF ISVIMDAYDTIK---------------------------------------QYYKDGF-------------- ------P---------------------------------------------KSDLQQFI------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------GETRIEEVSS------------------------------------------- ------------------------------------------------------------------------ -------------------------GL-----------------YRVHS----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------SSS----------------------- ------------------------------------------------------------------------ ------------LNAIMNS----------------------------------------------------- ------------------------------------------------------------------------ ------------LFCCNIY----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------R----- --S--------------------------------------------------------------------- ------------------------------------------------------------------------ ---------------A-------------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------------------YSKIGGRSST------------- ---------------------------------------------------VNLM----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ >BmWtrw/1-1012 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------MLHESES------------------------------- ------------------------------------------------------------AAEL-------- -------------------------------------------NCIL------------------------- ------------------------------------------------------------------------ --SACISVKFNVH----------------------------------------------------------- -------------------------------CQVYERP-------NNDDDKVRTIH-LVI----------DG RSTIAAESGEQ------------------------------------CVATSRM------------------ -----------PNTRR---------------LLPARWLRARAPDEPRPA----------------------- -DRRGRDLPDHESLERAYPSMGH---------------------------------LEYVLA-GSSPPAESA PNMY----------------------------------------DSFEE----------------------- ------PPLDLTAH----ICADSLRQSAHEQ-MRAV-G-------------------GRL-R--------LL DELES------------------------------------GVIPADATTDAFA-T--ATDA---------- ------------------------------------------EKNVCLFWTAFLKLANLLPPLIEV-GAEP- ---LYYD-S--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------LGL--------------------------------------------------------- SPLHV---------------------AAFSG-----SVECASYLLS--------------------CG-AD- ---------PNY--M---PRC--------------------------------------------------- -----------------------------------FAPL--HCAAFGNSVQVANLLIA-------------- --------------------------------------------RGA--SVHAAVKYI--NCE-------GG LLHCAVRANS-------------------------------------------------------------- ------A------ECLKLFIS-----------------------------HGV------DV----------- -----------------------------NL-I-----EPGGT-------NAIHLAAD-------------- ---------LGVKQCL--------IILLDTPGAD-PNVRTR------------------------------- ------------------------------------------------------------------------ -----VGDRESTAL--------HLAAD---------GGFVECVD---------------------------- ------LLL---------SKGADASLKN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---HRGFTAL--------------------------HLAARS----A------------------------S LECVE--------------------------------SLLRK-GN-ADPN-AMDF-------DKR------- --------------------------------------TPLHAAIGK----------SDSACDI-IETLISW GAN------------------------------------------VNQKDE-Y------------------- --------------------------GFT------------------------------------------- --------------------------------------------------------------------PLHL AA------------------LDGLS---------ACVETLIYHGADVTT-RSK------------------- -KGNSALNVI-------------------------------------------------------------- -------------------------------AR--KTP-ASLAMVTRKLDCAITLHHSQ-------SS-NRE VELELDFRS--------------------------------------------------------------- ILQH--------------------------------------------CYPREISYLNTFVDEG-Q-----K EVLLHPLCS-----------AFLYIK--------------------------------------WE------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------K------------------- ----------------IRKY-----------------YVARLFLSFIFVLCLTLYV-------------LTA L-------------------------------------------------AHNCY----------------- -NG-----------SKDMEE-------T---IQ---EQ---------------ELC---------------- ------------------------------------------------------------------------ ----QKQSILGDLLRKNPF----------------------------------VIE---------------- --------------MQWWVLAGITIFEIF---------RKVY-GIAGYS----------------------- TVKQYL-M----------QSENIIEW-F----------------------VIISVFLISY------------ ----------IYTN-----------------I-----------TY-TWQN--------HVG----AFAVLAG WTNLMMMIG----------------------------------------------QLPVFGT--YVAMYQKV QK-EFAKLLMAYSCILIGF--TISFCVIF----------------------PD------------------- --SSS-------------------------------------------FAN-P------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------FMG----- ---------------------FITVLTMMIGELN--LDLLLNEPDGN------------------------- -------D----PPVL-------------------------L---EFSAQ----ITYVLFLMFVTVVLMNLL VGIAVHDIQGLRKTAGLSKLVRQTKLI------------------------SYMELALFNGYL--------- ------P------------------------------------KCLL----------KILHS---------- --SA-LVS----------------------------PQAYRVV--------------------LSV------ --------------------------KPLNPSEKR------------------------------------- -----------------LPRDI-MMAA--------YDI-------------------------AKMR-K--- ----------------------------------QYGH-------------TISSSGSTTGAYSCFKKYESN NDSGYREY-----------------GY----------SGLGS--IHA------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------RLD--------------------ETSEH---------- ---------------------------------------------------------------VRQLTQE-- ------------------------VK-----------------EL--------------------------- ------------------------------------------KK-LINAQQL-------------------- ------------------------------------------------------------------------ -----------VIQQALVG----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------AMDRP----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >BmWtrw2/1-973 ------------------------------------------------------------------------ --MD-------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------NFGYREMGW------------------------------ --------------------------------------------------------PSPLQTPT-------- -------------------------------------------RSRL------------------------- ------------------------------------------------------------------------ --SSSIRSRGR------------------------------------------------------------- --------------------------------EPEEFPL------NPQYKHVKNID-L-------------- ------------------------------------------------LESARE------------------ -----------PGKAK-------------------------------------------------------- ---------------------------------------------------------EYLFV-GPSPPADDA PNMY----------------------------------------HSFDV----------------------- ------LAPDPDAR----LTDDAARRGLYERALTLG-A-------------------GR-----------FF DDLEC------------------------------------GLITAENIEEHIS-S--APEA---------- ------------------------------------------VVNLTLLWASYLARDELLPGVLDA-GADI- ---HYSD-S--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------SGL--------------------------------------------------------- TALHL---------------------SAFSG-----AGRAAVFLIS--------------------RG-AD- ---------VDF--V---PKY--------------------------------------------------- -----------------------------------FTPL--HCAAFGNSLEVAEILIA-------------- --------------------------------------------NGA--SLHGVVQRA--GCE-------DN LVHCAVRADA-------------------------------------------------------------- ------V------ECMEMFIE-----------------------------RGV------DP----------- -----------------------------AY-A-----TSGGL-------NALHLAAE-------------- ---------LGSRRCL--------SYLLRETKIS-VNGMSK------------------------------- ------------------------------------------------------------------------ -----QRDKECTAL--------HLAAS---------RGYVECVE---------------------------- ------LLL---------SEGAKANTKN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---YRGFTAL--------------------------HLAARL----S------------------------S IDCVE--------------------------------VLLRD-GN-ADPN-AEDY-------DKR------- --------------------------------------SPLHAAITR----------SERACDI-IELLVNW GAQ------------------------------------------VNKKDE-Y------------------- --------------------------GYS------------------------------------------- --------------------------------------------------------------------AIHL AA------------------MDGLT---------QCVETLIFLGADVTS-KSK------------------- -KGHTALSVI-------------------------------------------------------------- -------------------------------AR--KTP-KSLAILKHNLDCGISLSRSI-------EG-NEE VQIEFDFGK--------------------------------------------------------------- LLKF--------------------------------------------SYPREITYLNSLVDEG-Q-----K DILQHPLCS-----------AFLFMK--------------------------------------WR------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------K------------------- ----------------IRKF-----------------YLARLIFCFLFVSFLSIYV-------------LTA V-------------------------------------------------VKAC------------------ -QG-----------KHSKKY-------G---VP---N----------------ELC---------------- ------------------------------------------------------------------------ ----QPQSILGVILNDNP------------------------------------IE---------------- --------------FERWVLMAITVFEIV---------RKLT-GITGYS----------------------- SFYQYF-T----------TFENLMEW-F----------------------VLLSVFSLYN------------ ----------IRND------------------------------Y-SWQN--------HVG----GYAVLGA WTNLMLMMG----------------------------------------------QLPMFGD--YVAMYQKV LM-EFLKLLLAYICLLLGF--TICFCVVF----------------------PN------------------- --EEM-------------------------------------------FSN-P------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------LMG----- ---------------------FISTLSMMVGELN--LNILINDPMQD------------------------- -------D----PPIF-------------------------F---ELSAQ----IIFIFFLMFVTIILMNLL VGIAVHDIQGLRKTAGLSKLVRQTKLI------------------------LFVEMGMFSAWL--------- ------P------------------------------------KCLH----------KYVYR---------- --TA-LVS----------------------------PEAGKVI--------------------LSV------ --------------------------KPLNPREKR------------------------------------- -----------------LPTDI-MMAA--------YEL-------------------------AQLN-KVKS GRSVK---------------------------EVLYKN-------------KISSKLKNEG-------HNNE QNVGFEIR-----------------GM------------------QE------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------KID--------------------QATFN---------- ---------------------------------------------------------------LKKIDQE-- ------------------------MR-----------------HL--------------------------- ------------------------------------------NTLLMEQQN--------------------- ------------------------------------------------------------------------ -----------FFQSLFKST---------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------ELVPYKS---------------------------------------------- -----------------------------------------------------------------------Q HAS--------------------------------------------------------------------- ---------------------------TPVY---S------------------------------------- ------------------DSPII------------------------------------------------- ----------------FGNNT--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Cele_CED-11/1-1418 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------MDET---------------------------------------------------DPVPD---- ------------------------------------------------------------------------ ----MS------------LLPDTVP--------------------------VVVSGDGSA-A-----GIQLC PALILGSPQA--LPGAIK--------------------HIYSRLAAAASEV--------------------- --------------------------------------------DQGV--PDL------IISLISH-GNSL- ---STKYMSSV------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------ENG---------------- ------------------------------------------------------------------------ ---------------------LKSFLIGC------------------------------------------- ----------------------------------------GTWL---------------------------- --------ISSGE----------------VN----------------------------------------- ---------------------------DPMSRVAS--------------------------------G-AL- ---------KNVLPQL--EHQAEVLHILVNSDDMIASDTTNSKSVVD------------------------- ----------------------------------TSLNT--LLLICRKEPNDSYETVA--SSIAKL------ ----------------------------------------------------------------------RA ATAVKLAHPPPALLI------GVPSEPMSPSTYGNSAAILLSPSNDKRP-------------FPVAIFA--- --GASKE------SLIELLFFVE-----------------------------------HGI----------- -----------------------------PV-I-IL-QDS-------CELCAILHS---------------- -----------------------SHLLLET------------------------------------------ ------------SN---------------------------------------------------------- ------------------FDN----------DKFI---SW-------------------------------- ---------L----------RSQLYPLGL------------------------------------------- -------------------------------------------------------ADC-------------- ------------------------------------------------------------------------ ---YTLITKL--------------------------LVSSNS----G------------------------D VQLIE-FIDSSQLSELSSVVVDRCLECYATTGEERQVLLLAA-K--LNSPSVLSSMDVAAQLDEEL------ --------------------------------------LTMILC---------ECITK---DDQ-LHFLSSV ------LQLSPPIRVTSNMLIRMMHHADEHFFT----TIVLCQCMGYSYIPSEI-----------DPRFAND IQKLVKKLS---------FG----------------------------------------------VDNLFD PNVFCNDSS---------------HRDKH--------------------------------------ESIRI LAIWSL--------------LLHRP---------GIVKCLAAFADEPVA----------------------- -FSMVLSRIARSLGHESHD----------------------------------------------------- ------------------------WHFYEKSLN--TLSDSLSGSATTLFDTVFSTSPA-------------K AYQLLCQPME-------------------------------------------------------------- -------------------------------------------------YFYGFNMTQLAFHCN-A-----R EIIAHECCQRWV------HRKLYGNL-QAK----------NFPIFLPKWAKICISAVLIIPVKFWMLVRPRE RTKQDTVSPTVALLDVGKFPQKQRAISTYSVISSRSEALTALTAPLST--AFGFNSALNGAESATPQSMVFP LNIEEIDKDPRP------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------FGK-KNRIRRAHAPTLSTFYSTPIVKYWLSLLFRIVFICCLAYSVVLPGCGSNLW------ -----------------------------------------------------DT----------------- ---------------------------G-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------MWVWSFFWWIENCFVLTARAR-KI--PLSLM------------P------- --------------------WRVFDVFA-------------------FFVFLILLLVMKV------------ ---------FPVTP-----------------VL-------------EVLGIDSIYSAKVVS---AFFVLYVS YSTLFTYIP----------------------------------------------LSDIFGP--MIVRVKLM LLRDFTNFLFMIALVMLSS--AVAIQAVVFPD-------------------RP------------------- -------------------------------------------VTMEVFRK--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------T----- ---------------------LSWIWLSLFT-TD--LSNLS-ESETCRKSFLGAPKRYCSSVGQYA------ -------NPSCPSQSLPAY-----------------------------------LIVIEYFVILKLLLWPIL FAFFSKTAKNVDDEADKIWRFQLYSLA------------------------EDFRLR--------------- ---PPLP-------PP--------------------LTIFC-----------------LICS-------ACC RFSN----------------SFSGFFSDFDHPDFEARDKCRTTWKFGSI---YRNPSVPFKRNEFVNSFWR- -------------------------KLSMEQWKNT------------------------------------- ------------QQKAKISANK-SE--LQELHNIHNHI----------------------------RMMTLR DSYENS-----------------------------------------------------GTRKASE------ ------------------------LQF-----------------FEKY-----------PESNILKISV--- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------NMVSK----------- ------------------------------------------------------------------------ ----------------------------------------PWTVLVPR-YNPPFY-----CKPAEDFPSDVQ KYVDIATEQNV-GE---------LKRIWR------------SRQANDVTSSND------------------- ------------------------------------------------------------------------ --------------------------------------KCWK------------------------------ --------------------------LSAAGF-P-LNPNGRTGMAGR-----GNHPRFGANR---------- -------------------------------RCYYVVLSGGVE----------------------------- ---------AKCQVLVDSQ--------------KNIPNEWHL---ENSS---------KDEHLTSI------ ---------------LKMIGISDSDAHM----------------FSM--------------------RRLDS SI-------------------ITADKRIPSN--DTSPAHLASEVAENENDT--------------------- -----------------------------------DNAWTEHD------------VWAI------------- -------------------------SLRERRII-TTIIGYSWL----------------------------- ---------------P-------------------------------------------------------- ------------------------------------------------------------------------ --------------------------------------------------TSAIRGTV-------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------LPWQADLVFRAKTIY---------GL----------------------------------- >Cele_CUP-5a/1-607 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---MSRRSTTDRSD---------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------FNDN---------------------- --------------------------------ASNA---------------------SSN------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------ASRR--------------------------------- PTINF---------------------QEIMED---------------------------------------- ------------------------------------------------------------------------ -----------------------------------------LPHHERETGERLRRHLQ-------------- ---FF--------------------------------------------FMNPMEKWK---------VRHQL PYKLVL------------------------------------------------------------------ -------------QVLKIVFV--------------------------------------------------- --------------------------------T-M---------------QLILFAEMR------------- ---------MSHVDFLEDTTTVMRHRFLKEWNDD-------------------------------------- ------------RD---------------------------------------------------------- -ALQYPPAEGRYSV-------------------YDDQGLSEHLS---------------------------- ------FLINSYYSIRNDSFASFSYDVVSHPSGN-------------------------------------- ------------------------------------------------------------------------ ---------------------------------------------------------------------LGA QISFESIPPIEVLIDRISN------------------VTVNN----N---------------TYNFD----I REVKDT-------KRLNLTETE-VFQIGQSDDAVRD-ILATR-G--ITFL-PEDA----------------- --------------------------------------LKISTVQ--------------------FKFRLRT IHYSP-------------------------------------TAGDQKPEC--------------------- ------------------------------------------------------------------------ -------------------------------------------------------------------YKISV SIK-----------------FDNSR----------------------------------------------- HTGQVHVTLS-------------------------------------------------------------- -------------------------------------------TVVSYVNVCNGRIIKGV-----GWSFDTL LIGGTDIFVL-------------------------------------------------------------- -------------------ILCIL-----------------------------------------SLILCCR ALIKAHLLQIKTS-------DYFENVLKNKITVTDQLDFLNL----------------------WY------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------VMIVVNDALIII---G-----TVAKISI--------------------------- EFQDFD-N----------SLFTLTSIFL-------------------------------------------- -----------------------------------------------------------------GMGALLV YVGVLRYFG----------------------------------------------FFSQYNI--LMLTLKRS AP-NIMRFMTCAIVLYAGF--LIAGWVIIGPYS--------------------------------------- --------------------------MK--------------------FRT-L------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------AES----- ---------------------SEALFSLLNGDDM--FATFYTIND-S------------------------- ---------------------------------------NTVI--KVFGT----VYIYLFVSLFIYVVLSLF IAIIMDAYEVVK---------------------------------------DRYSDGLR------------- ---AIEK---------------------------------------------RGCLRDFVES---------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------NPPPSEL-GSPTTR------------------------------------------- ------------------------------------------------------------------------ -------------------------SA-----------------YAPSN----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------LLNL------------------------ ------------G----------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------RGWQRL E----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Cele_GON-2a/1-2032 ------------------------------------------------------------------------ -MMSDDMLDE--------NDENFACQDVDE--------------------------------IIIYVPEFAG -----------------------------YREVNIDTAVSVCPTP--------------------------I QQARRESSCRNLEMR-------RRFEK----------------LRREKKEEKKLLADDEKDFDEDDDVFEDG EGLQMRTFQPNASIRDENGSMPSLLPRTAPIKKTRKHRRRRSGSFTGGVYPRKGHRNRSLLGHAIPPPNVHS ADWRDMLAITDNKDDKLMKTLGVTRYLQSKGGDQVPPTSTTTG----------GAGGDGNAVPTTSQAQA-- ---------------------------------QTFNSGRQTTGMSSGDRLN--------------EDVSAT ANSAQLVLPTP---LFNQ-----------------------------------------------MRFT-ES NMSLNRHN---------------------------------------------------------------- ----------------------------------------------WVRETFTRRE----------CSR--- ---------------------------------------------FIASSR-DLH----------------- --KCGCGRTRDAHRNIP-ELTSEFLRQKRSVAALEQQRSISNVNDDINT----------------QNMYTKR GANEKWSLRKHT---------------------------------------------------VSLATNAFG QVEFQGGPHP--------------------------------YKAQYVR----------------------- ------------------VNFDTEPAYIMSL-FEHV--------WQISPPRLIITVHGGT-S-----NFDLQ PKLAR---------------------------------VFRKGLLKAASTT--------------------- -----------------------------------GAWIITSGCDTGV---------------VKHVAAAL- ---EGAQSA--------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------QRN---------------- ------------------------------------------------------------------------ ----------------------KIVCIGI------------------------------------------- ----------------------------------------APWG---------------------------- --------LLKKREDF-------------IG-----QD---------------------------------- KTVPY----YP-S--------------SSKGRFTGLNNRHSYFLLVDNG-------------TVGRYG-AE- ---------VILRKRL--EM-------------YISQKQKIFGGTR-------------------------- -----------------------------------SVPV--VCVVLEGGSCTIRSVLD--YVTNVP------ -----------------------------------------------RVPVVVCDG-----------S-GRA ADLLAFAHQNVTED-------GLLPDDIRRQVLLLVETTFGCSEAAAHR-------------LLHELTV--- --CAQHK------NLLTIFRLG---------------------------EQGE-----HDV----------- -----------------------------DH-A-I--------------LTALLKGQN-------------- ---------LSAAD----------QLAL-------------------------------------------- ------------------------------------------------------------------------ ------------AL------------------------AWNRVD---------------------------- ------IA------------RSDVFAMGHEWP---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------QAAL----------------------HNAMMEALIH----D------------------------R VDFVR--------------------------------LLLEQ-G--INMQKFLTI--------SRL------ --------------------------------------DELYNT-------------DKGPPNT-LFYIVRD --------------------VVR--VRQGYRFKLPDIGLVIEKLMGNSYQCSYT-----------TSEFRDK YKQRMKRVKHAQKKAMGVFSSRPSRTGSGIASRQSTEGMGGVGGGSSVAGVFGNSFGNQDPPLDPHVNRSAL SGSRALSNHILWRSAFRGNFPANPMRPPNLGDSRDCGSEFDEELSLTSASDGSQTEPD------FR-YPYSE LMIWAV--------------LTKRQ---------DMAMCMWQHGEEAMA----------------------- -KALVACRLYKSLATEAAED---------------------------------------------------- ----------------------YLEVEICEELK--KYAEEFRILSLELLDHCYHVDDA-------------Q TLQLLTYELS-------------------------------------------------------------- -------------------------------------------------NWSNETCLALAVIVN-N-----K HFLAHPCCQ-----------ILLADL--------------------------------------WH------ ----------------GGLR--MRTHSNIKVV------LGLICPPFIQ--MLEFK----------------- -TREELLNQPQTAAEHQNDMNYSSSSSSSSSSSSSSSSSDSSSFEDDDDENNAH-----NHDQ--------K RTRKTSQGS--AQSLNITSLFHSRRRKAKKNEK-----CDRETDASACEAGNRQIQ-NGGLTAEY------G TFGESNGVSPPPPYMRANSRSRYNN-----RSDMSKTSSVIFGSDPNLSKLQKSNITSTDRPNPMEQFQGTR KIKMR-----------RRFY--------EFYSAPISTFWSWTISFILFITFFTYTL-------------LVK TPP--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------RPTVIEYILIAYVAAFGL---------EQVR-KI--IMS----DAK-----------PFYE KIRTYV-C----------SFWNCVTILA-------------------IIFYIVGFFMRCFGS---------- -----------------------------------------------------VAYGRVIL----ACDSVLW TMKLLDYMS----------------------------------------------VHPKLGP--YVTMAGKM IQ-NMSYIIVMLVVTLLSF--GLARQSITYPD-------------------ET------------------- -------------------------------------------WHWILVRN--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------I----- ---------------------FLKPYFMLYGEVY--ADEID----T------------CGDEAWDQHLENGG PVILGNGTTGLS--CVPGY---------------------------WIPP----LLMTFFLLIANILLMSML IAIFNHIFDATDEMSQQIWLFQRYKQV------------------------MEYEST--------------- ---PFLP-------PP--------------------LTPLYHGVLILQ----------FVRT-------RLS CSKS----------------QERN---------PMFDFSLKLFLDN------DQIEKLHDFEEDCMEDLAR- -------------------------QKLNEKNTSN------------------------------------- ------------EQRILRADIR-TDQILNRLIDLQAKESMGRD----------------VINDVESRLASVE KAQNEILECVRAL-------------------LNQNNAPTA------------------IGRCFSPSPDP-- ---------------------------------------LVE------------TANGTPGPLLLKLP---- ---GTDPIL--------------------------------------EEKDHD-------SGEN-------- ---------------------------------------SNSLPPGR---------------IRRNRTATIC GG-----------------------------YVSEERNMMLLS-------------PKPSD-------VS-G IPQ--------QRLMSVTSMDP---------------------------------------LPLPLAKLSTM ---------------SIR-RRHEEYT-----------SITDSIAIR----------------------HPER RIRNNR-----------------------------------SNSSEHDESAVDSEGGG-------------- -------------------------------------------------NVTSSPRK--------------- ------RST----RDLRMT----------------------------------------------------- -----------------------PSSQVEEST-S-RDQIFE-----------IDHPEHE------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------EDE---------------------------------------------AQA DC------------------------------------------------------ELTDVITEEE--DEEE DDEEDDSHERHHIHPRRKSSRQNRQPSH-----TLETDLSEGEEVDPLD---------VLK----------- ----------MKELPIIHQ------ILNEEEQ--AGA----------------------------------- ---------------P-HSTPV--------------I----------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------ASPSSSRADLTSQK------------ ------------------------------------------------------------------------ --------------------------------------------------CSDV------------------ >Cele_GTL-1/1-1694 ------------------------------------------------------------------------ --MDRKRGS--------------------------------------------------------IVPA--- ----------------------------------IHKAVA-------------------------------- -ESLRANSVTVEE--------------------------------NESERE--------------------- -------------------------------TETQTKRRRKKQRSTSS------------------------ --------------------------------DKAP----------------------LNSAPRHVQKFDW- --------------------------------KDMLHLA-DISGRKRGN--------------------STT SHSGH---------------------------------------------------------------A-TR AGSLKGKN---------------------------------------------------------------- ----------------------------------------------WIECRLKMRQ----------CSY--- ---------------------------------------------FVPSQR-FSE----------------- --RCGCGKE-RSKHTEE-VLERSQNKNHPLNHL--TLPGIHEVDTTDAD----------------ADDNEVN LTPGRWSIQSHT---------------------------------------------------EIVPTDAYG NIVFEGTAH----------------------------------HAQYAR----------------------- ------------------ISFDSDPRDIVHL-MMKV--------WKLKPPKLIITINGGL-T-----KFDLQ PKLAR---------------------------------TFRKGIMKIAKST--------------------- -----------------------------------DAWIITSGLDEGV---------------VKHLDSAL- ---HDHGNH-T------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------SKN---------------- ------------------------------------------------------------------------ ----------------------HVVAIGI------------------------------------------- ----------------------------------------ASWG---------------------------- --------MLKQRSRF-------------VG-----KD---------------------------------- STVTY----ATNV--------------FNNTRLKELNDNHSYFLFSDNG-------------TVNRYG-AE- ---------IIMRKRL--EA-------------YLAQ---GDKKRS-------------------------- -----------------------------------AIPL--VCVVLEGGAFTIKMVHD--YVTTIP------ -----------------------------------------------RIPVIVCDG-----------S-GRA ADILAFAHQAVSQN-------GFLSDNIRNQLVNIVRRIFGYDPKTAQK-------------LIKQIVE--- --CSTNK------SLMTIFRLG---------------------------ESSR-----EDL----------- -----------------------------DH-V-I--------------MSCLLKGQN-------------- ---------LSPPE----------QLQL-------------------------------------------- ------------------------------------------------------------------------ ------------AL------------------------AWNRAD---------------------------- ------IA------------RTEIFANGTEWT---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------TQDL----------------------HNAMIEALSN----D------------------------R IDFVH--------------------------------LLLEN-G--VSMQKFLTY--------GRL------ --------------------------------------EHLYNT-------------DKGPQNTLRTNLLVD --------------------SKH-------HIKLVEVGRLVENLMGNLYKSNYT-----------KEEFKNQ YFLFNNRKQ---------FGKRVHSNSNGGRNDVI---------GPSGDAGRERMSSMQ----ISLINNA-R NSIISLFN----------------------GGGRK--RESDDEDDFSNLEEEANMDFT------FR-YPYSD LMIWAV--------------LTKRQ---------KMAKLMWTHGEEGMA----------------------- -KALVASRLYVSLAKTASLA---------------------------------------------------- ----------------------TGEIGMSQDFT--EFSDEFSELAVEVLEYCTKHGRD-------------Q TLRLLTCELA-------------------------------------------------------------- -------------------------------------------------NWGDETCLSLAANNG-H-----R KFLAHPCCQ-----------MLLSDL--------------------------------------WQ------ ----------------GGLL--MKNNQNSKVL------TCLAAPPLIF--LLGFK----------------- -TKEQLMLQPKTAAEHDEEM---SDSEMNSAEDTDTSSDSSSDSDDSDEEDAKLRAQSLSADQPLSIHRLVR DKLNFSEKKKPDMGISRIVVAPPIVTGRNRART-----MSIKKSKKNVIKPPACLKIETSDDDEQEQKKATE MYINRTGKRGSVA-VAMNHDDMYIDPSEELDTQTRQKSSREFSSSRNVTV----------------QVYTQR PLSWK-----------KKIM--------EFYKAPITTYWLWFFAFIWFLILLTYNL-------------LVK TQR--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------IASWSEWYVFAYIFVWTL---------EIGR-KV--VSTIMMDTSK-----------PVLK QLRVFF-F----------QYRNGLLAFG-------------------LLTYLIAYFIRLS------------ -------------------------------------------------PTT-KTLGRILI----ICNSVIW SLKLVDYLS----------------------------------------------VQQGLGP--YINIVAEM IP-TMIPLCVLVFITLYAF--GLLRQSITYPY-------------------ED------------------- -------------------------------------------WHWILVRN--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------I----- ---------------------FLQPYFMLYGEVY--AAEID----T------------CGDEIWQTHEDENI PI--SMLNVTHET-CVPGY---------------------------WIAP----VGLTVFMLATNVLLMNVM VAGCTYIFEKHIQSTREIFLFERYGQV------------------------MEYEST--------------- ---PWLP-------PP--------------------FTIIYHVIWLFK----------LIKS---------- SSRM----------------FERK---------NLFDQSLKLFLSP------DEMEKVHTFEEESVEDMKR- -------------------------ETEKKNLSSN------------------------------------- ------------DERIHRTAER-TDAILNRVSHLTQLEFTLKE----------------EIRELEHKMKNMD SRHKEQMN---------------------------------------------------------------- --------------------------L------------MLD--------------------MNKKLG---- ------------------------KFI--------------------------------------------- ---------------------------------------SGKYKRGS---------------FGGSGSDGGG G-----------------------------------------S-------------SDNSK-------LE-- -PN--------NSVPMITVDGP-------------------------------------------------- ---------------------------------------------------SPI----------------GS RRTSGQ---YL------------------------------KRDSLQAK----------------------- ------------------------------------------------------------------------ -------------KKITEN----------------------------------------------------- -----------------------------------------------------RRSSLEQ------------ ------------------------------------------------------------------------ ---------------------------------PKIPSIQ-------------------------------- -----------------FNLMEDQ------------------------------------------------ ----------------------------------------DESAAESATE------EVSISIPVPQ--MRVR QVTESD-----------------------------KSDLSEDD----------------------------- -------------------------LITREDA----------------------------------P----- ---------------P-TSINLPRGPR--------------------------------------------- ------------------------------------------------------------------------ --------------------------------------------------RHALYSTI-------------- ----------------------------------------------ADAIETEDDFYADSPVPM-P------ ------------------------------------------------------------------------ ----------MTPVQPAD---------------------GSFFGENDSRYQRDDSDYE-------------- >Cele_GTL-2/1-1406 ------------------------------------------------------------------------ --MINETKTN--------GISEETISD--------------------------------------------- ------------------------------------------------------------------------ ---------------------------------------------NEEEEE--------------------- ----------------------------------EEERHRTSSFLR-------------------------- ----------------------------------------------------------LLNAPRNSMCNA-- ---------------------------------NTVHS----ISSFRSDHLS--------------R----- -KSTHKFLDNP---NL---------------------------------------------------FA-IE LTEKLSPP---------------------------------------------------------------- ----------------------------------------------WIENTFEKRE----------CIR--- ---------------------------------------------FAALPK-DPE----------------- --RCGCGRP-LSAHTPA-STFFSTLP-----------------------------------------VHLLE KEQQTWTIANNT---------------------------------------------------QTSTTDAFG TIVFQGGAHA--------------------------------HKAQYVR----------------------- ------------------LSYDSEPLDVMYL-MEKV--------WGLEAPRLVITVHGGM-S-----NFELE ERLGR---------------------------------LFRKGMLKAAQTT--------------------- -----------------------------------GAWIITSGLDSGV---------------VRHVAKAL- ---DEAGISAR------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------MRS---------------- ------------------------------------------------------------------------ ----------------------QIVTIGI------------------------------------------- ----------------------------------------APWG---------------------------- --------VIKRKERL-------------IR-----QN---------------------------------- EHVYY----DVHSL-------------SVNANVGILNDRHSYFLLADNG-------------TVGRFG-AD- ---------LHLRQNL--EN-------------HIAT---FGCNGR-------------------------- -----------------------------------KVPV--VCTLLEGGISSINAIHD--YVTMKP------ -----------------------------------------------DIPAIVCDG-----------S-GRA ADIISFAARYINSD-------GTFAAEVGEKLRNLIKMVF--PETDQEE-------------MFRKITE--- --CVIRD------DLLRIFRYG---------------------------QEEE-----EDV----------- -----------------------------DF-V-I--------------LSTVLQKQN-------------- ---------LPPDE----------QLAL-------------------------------------------- ------------------------------------------------------------------------ ------------TL------------------------SWNRVD---------------------------- ------LA------------KSCLFSNGRKWS---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------SDVL----------------------EKAMNDALYW----D------------------------R VDFVE--------------------------------CLLEN-G--VSMKNFLSI--------NRL------ --------------------------------------ENLYNM--------D----DINSAHS-VRNWMEN --------------------FDS-MDPHTY-LTIPMIGQVVEKLMGNAFQLYYT-----------SRSFKGK YDR------------------YKRINQSSY-----------------------------------------F HRKRKIV----------------------------------QKELFKKKSDDQINDNEEEDFS-FA-YPFND LLIWAV--------------LTSRH---------GMAECMWVHGEDAMA----------------------- -KCLLAIRLYKATAKIAEDE---------------------------------------------------- ----------------------YLDVEEAKRLF--DNAVKCREDAIELLDQCYRADHD-------------R TLRLLRMELP-------------------------------------------------------------- -------------------------------------------------HWGNNNCLSLAVLAN-T-----K TFLAHPCCQ-----------ILLAEL--------------------------------------WH------ ----------------GSLK--VRSGSNVRVL------TALICPPAIL--FMAYKPK--HSKTARL------ LSEETPEQLPYPRESITS--------------TTSNRYRYSKGPEEQKETLL-------------------- -----EKGSY-TKKVTIIS-------------------SRKNSGVASVYGSASSMM---------------- -------------------------------------------------------------------FKREP QLNKF-----------ERFR--------AFYSSPITKFWSWCIAFLIFLTTQTCIL-------------LLE TSL--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------KPSKYEWITFIYTVTLSV---------EHIR-KL--MTS----EGS-----------RINE KVKVFY-A----------KWYNIWTSAA-------------------LLFFLVGYGFRLVPMYR-------- -----------------------------------------------------HSWGRVLL----SFSNVLF YMKIFEYLS----------------------------------------------VHPLLGP--YIQMAAKM VW-SMCYICVLLLVPLMAF--GVNRQALTEPNV------------------KD------------------- -------------------------------------------WHWLLVRN--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------I----- ---------------------FYKPYFMLYGEVY--AGEID----T------------CGDEGIR------- --------------CFPGY---------------------------FIPP----LLMVIFLLVANILLLNLL IAIFNNIYNDSIEKSKEIWLFQRYQQL------------------------MEYHDS--------------- ---PFLP-------PP--------------------FSIFAHVYHFID----------YLYN--------LR --RP----------------DTKR---------FRSEHSIKLSVTE------DEMKRIQDFEEDCIDTLTR- -------------------------IRKLKLN--T------------------------------------- ------------KEPLSVT-DL-TELTCQRVHDLMQENFLLKS----------------RVYDIETKIDHIS NSSDEVVQ---------------------------------------------------------------- --------------------------I------------LKN------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------KKLSQN----------------------------------------------------- --------------------------FAASSL-S-LPDTSI------------------------------- ------------------------------------------------------------------------ ----------------------------------EVPKIT--------------------KTLID------- -------------CHLSPVSIEDR---------------------------------------------LAT RS------------------------------------------------------PLLANLQRD---HTLR KYDDANFQ--PGKLQRRA------------------------------------------------------ -------------------------RLHSSSC--SISQD--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------MKEMKTSM-------------- --------------------------------------------------SSRNLKREDSG----------- ------------------------------------------------------------------------ ----------------------------------------EITTSSHGGYDSDVSGPD-------------- >Cele_OCR-1a/1-850 ------------------------------------------------------------------------ --MGTKNSKI-------------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------------------ADG------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------AAQVEQ------ ------------------------------------------------------------------------ --------------------------------------------------------------TMARTM---- ------------------------------------------------------------------------ ----------------------------------------------SENKVIYKMV---------------- ------------------------DMHGGGILIKL------------------------------------- --------ARKCKELN-------------------------------------------------------- ----SFVLLDAY------------------------------------------------------------ ------------------------------------------LDQEVRKY---------------------- --------------------------------MYNG---------------------GKG-K-----LMPVA ELVKARNKERN------------------------------AKLGAFSRKKG-------------------- --------------------------------------------------------------------KGK- ---SGPNIL--------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------DE----------------- --------------------------------------------FDQGQAE---------------MAGDLK KA-------------------LKLLDGGGKGGKSESKY-----------------------RE--------- ----------------------------------------MVWS---------------------------- ---------VDERGSMG-------------------E----------------------------------- NLLAI-------------------------------------CLLQ-------------------------- ------------------------------------------------------------------------ -----------------------------------GSAL--HNL-------IARRLIN-------------- ---FF---------------------------------------PKLINDICVSEEYY-----------GLS PLHLAI------------------------------------------------------------------ --VNQD------AQFTSLLLR-----------------------------LGA------DLNQRCYGAFFCA DDQKASRTDS---------LEHEFVELTKN--T-----NYTGSMY--FGEYPLSFAIC-------------- ---------MGQHDLF--------RMLLAK-KAN-------------------------------------- ------------LS---------------------------------------------------------- ----AQDTNGNTAL--------HLCVI---------HDKMDMLD---------------------------- ------AVL---------EAGGNIRLAN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---KQNLTAL--------------------------TLAARL----A------------------------K KTMFN--------------------------------KILQL---------ECEK-------VWTY------ --------------------------------------GSSQCVA--------------------------- -------------------------------------------YPLTKIDTIDE------------------ ------------------------TTGEM------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -NDTSALSLV-------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ VYGESIQ----------------------------------------------------------H-----L ELMDG-LIE-----------QILDEK--------------------------------------WK------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------A------------------- ---------------YGRAL-----------------WLRSLLGFIFFYCCFVCAY-------------MLR PS------------------------------------------------------------SATTEHLTRG -RINDDGE-------TEST--------N---STN-------------------------------------- ---------------------------------------------------YLQ------------------ ------------------------------------------WHAIDTQ--CHLMY-------YSAW----P W-------------YHGWFRLGCEIMTII---------VMLF-QI--LLD--------FGD-------IRRI GFQKWF-N----------FLKAFPAKLM----------------------FKGAFLFIIISIPCRLA----- -----------------------------CSFH---------EFFLTIDN--------TMA----IISILLV TQHFLYYMR----------------------------------------------AIPFVGP-FVLMVYTII AT-DLVRFAMIYSIFLVGF--SQSFYLIF----------------------TSC------------------ ERDSTAIKKIDPMGSE----------------------------FNNIMEN-P------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------VDA----- ---------------------LLRTFIMTIGEFSVLYREMSAC----------------------------- ----------------------------------------DNFWMKWIGK----LIFVIFETFVSILQFNLL IAMMTRTYET-IFLTRKEWKRQWAQVI------------------------LMLEMGLSPASRKMHLL---- --RYTRPTGINKR-----------------------------VRSYVV---------VSKGE---------- -GER----------------TEKNELAA-----REAKEEQKRE------------------ERRQLLKKKQR EHEVKAKALAMMS----------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------AKL--------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------HIEVKK----------------------------------------------- ------------------------------------------------------------------RRILRQ QTV--------------------------------------------------------------------- ---------------------------DANSK--M------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Cele_OCR-2a/1-900 ------------------------------------------------------------------------ --MGSSSSTQ-------------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------------------SSM------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------NNFV-------- ------------------------------------------------------------------------ --------------------------------------------------------------GMGR-L---- ------------------------------------------------------------------------ ----------------------------------------------REDMKIYQLV---------------- ------------------------DMHGGGELLPW------------------------------------- --------LRYAIISS-------------------------------------------------------- ----DTSFIDAY------------------------------------------------------------ ------------------------------------------LETKVKDF---------------------- --------------------------------LYNG---------------------GKG-K-----LVTVT ELVKLRNKERN------------------------------ERLGAFSRKKG-------------------- --------------------------------------------------------------------KGK- ---SGPNVL--------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------DD----------------- --------------------------------------------FNQ-EGE---------------NVGDLK KA-------------------LKLLDGGGKGGRNESKY-----------------------RE--------- ----------------------------------------ISWK---------------------------- ---------LEERGSMG-------------------E----------------------------------- TIIGC-------------------------------------CLLH-------------------------- ------------------------------------------------------------------------ -----------------------------------ASDI--HNA-------LVLKILD-------------- ---YY---------------------------------------PKLLNDIHISEDFY-----------GLS PLHQAI------------------------------------------------------------------ --INTD------CKLVYKFLK-----------------------------LGA------DVNSRCYGAFFCA DDQKASRTDS---------LEHEYVELSLK--T-----NYTGNMY--LGEYPLSFAAC-------------- ---------LNQPESF--------RLLLAF-KAN-------------------------------------- ------------PN---------------------------------------------------------- ----AQDTNGNSVL--------HMCVI---------HENMAMFK---------------------------- ------LAL---------ECGASLRTVN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---KQSLSPL--------------------------TLAAKL----A------------------------K KEMFD--------------------------------EILEL---------EGDS-------VWAY------ --------------------------------------GDASSTA--------------------------- -------------------------------------------YPLAKIDTINE------------------ ------------------------TTGEL------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -NEASALSLV-------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ VYGQTVE----------------------------------------------------------H-----L ELLDG-LLD-----------TLLEAK--------------------------------------WE------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------A------------------- ---------------FAKRN-----------------MIVSFTAFTLYYICFVTAF-------------TLR PI------------------------------------------------------------GFSTEMLTEG -WINRYSEPFPGRYGKNSTLQQVKPVIN---ATSR------------------------------------- --------------------------------------------------GLVE------------------ ------------------------------------------WSEPLSQ--CHLRN-------Y--WDPDIP F-------------ANSYIRLVFELFVVI---------GICV-QV--FLD--------FRD-------IKRI GRKKWW-N----------VLTAFPAKIT----------------------FKLTYFLVLAMIPTRLA----- -----------------------------CDLS---------PVLLVVDN--------VLI----TVTMIFT TVHYLYYCR----------------------------------------------VIRFVGP-FVLMVYTII AT-DIFRFMLIYGIFLMGF--SQSFSLIF----------------------LSC------------------ EREANVIKKLITDQSEASEGSDNKFNLTRQISAYDTAIVKNAEVFENVMQS-P------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------IEA----- ---------------------FVRTFILTIGEFTVLYRNLALC----------------------------- ----------------------------------------PANTMVWIGK----VVFILFELFVSIMQFNML IAMMTRTYET-IFQTQLEYKRQRAQVI------------------------LMLELSLSPKERHQYLL---- --KYSRPTGTNKK-----------------------------TRSLVV---------SKKSA---------- -FSR----------------DSKKGQKV-----LEEKMKKMIE------------------EKKAVLKRKMK DMEIKEGIRPVTG----------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------YS---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------------RTPRP HTQ--------------------------------------------------------------------- ---------------------------YMNRG--AG------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------GGANGVQNGNG------------ ------------------------------------------------------------------------ ---------AAH------------------------------------------------------------ >Cele_OCR-3/1-818 ------------------------------------------------------------------------ --MSFNSSDV-------------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------------------PS------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------TLYSLV---------------- ------------------------DEQGGGILSPW------------------------------------- --------IKYARSSG-------------------------------------------------------- ----DYSILEEY------------------------------------------------------------ ------------------------------------------LDTAVKSY---------------------- --------------------------------LYNG---------------------GKG-K-----LVPIS QLVTIRNKQRN------------------------------ALLGALRRKKG-------------------- --------------------------------------------------------------------RGK- ---SGPNIL--------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------EH----------------- --------------------------------------------IDQ-DAL---------------SSGDFL KA-------------------LKVLDGGMIKGRRSFKY-----------------------RE--------- ----------------------------------------LVWD---------------------------- ---------MDQRGRLG-------------------E----------------------------------- NLLHV-------------------------------------CMLL-------------------------- ------------------------------------------------------------------------ -----------------------------------NTAD--MNE-------LVKQMTY-------------- ---RF---------------------------------------PKIVNDIFLSEEYY-----------GLS PLHQAI------------------------------------------------------------------ --VNED------LEMVYFLCR-----------------------------KGA------DVHQRCYGSFFCA DDQKASRTDS---------LEHEWVDLVQS--T-----KYTGQMY--WGEYPLSFAAC-------------- ---------TNQVDCF--------RLLRAM-KAD-------------------------------------- ------------PN---------------------------------------------------------- ----MPDTNGNTVL--------HLTVI---------HDLPEMFM---------------------------- ------LAV---------ELGANLHVRN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---NLKLTPL--------------------------ALAARL----A------------------------K KHIYD--------------------------------LILEC---------DMDI-------SWRY------ --------------------------------------GPVVCKA--------------------------- -------------------------------------------YPLNDVDTINE------------------ ------------------------SDGSL------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -NPNSVIANV-------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ VYGDKVD----------------------------------------------------------H-----L EFFDG-LIE-----------EVLESK--------------------------------------WE------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------T------------------- ---------------FGKKQ-----------------LFMSLAGYIYFLAVFYLAF-------------MTR DAHILP--------------------------------------------------------SDEDENEKFG -MIELDFS-------------------N---FTNIL---------------SEGLSLREHLA---------- ------------------------------------------------IARMAE------------------ ------------------------------------------REALPAH--CHL------------WDYSGP ---------------SQQIRMISEILCLL---------AVVI-RT--FKD--------CID-------AHRT GVSRWW-N----------SIKAFPEKVL----------------------HKFCQILVLCTVPLRVG----- -----------------------------CYLD---------DSFLVIEN--------LLV----VCIVIMS TLHFLFYCR----------------------------------------------SLKFVGP-FVLMVYKII VR-DMLRFLLIYSFFLMGF--AQAFFVIF----------------------KSC------------------ ERAEIAYQKAHNYTED------------------DEYIEK----FENIMED-G------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------WEA----- ---------------------VMRMFIMSVGEFGALYKNLNEC----------------------------- ----------------------------------------KS-SIAPQSK----VFFILFELIVTVMLLNLL IAMMTRTYEK-IAETEKEWKRQWAQVI------------------------LMLEQSSSASERLLSLY---- --RYTRPIRSDKR-----------------------------RRAFVV---------KVKS----------- -------------------------------------------------------------NDRQQPQLKLI PPRGKPSIRLSNN----------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------SSI--------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------HVL-------------------------------------------------- -------------------------------------------------------------------HVLSK HAS--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Cele_OCR-4/1-756 ------------------------------------------------------------------------ --MGNASSAV-------------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------------------TAG------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------IKNQV------- ------------------------------------------------------------------------ --------------------------------------------------------------NASN------ ------------------------------------------------------------------------ -------------------------------------------------NAINKLA---------------- ------------------------DMSGRGFLADL------------------------------------- --------AMDAVRTG-------------------------------------------------------- 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------------------------------------------------------------------------ -----------------------------------GLPN--HMK------LLAERLIA-------------- ---IF---------------------------------------PKIINDFYLSDEYY-----------GET VLHMGI------------------------------------------------------------------ --VSEN------AEFVRYLLK-----------------------------SGA------DVHARCSGNFFTC DDQKGSRTDH---------PEVEHAIISKH--T-----KYPGHIY--WGEYPLSFAAC-------------- ---------LSQPECI--------RMLVAH-GAD-------------------------------------- ------------VN---------------------------------------------------------- ----AADTNGNTIL--------HICTI---------HENYEMFK---------------------------- ------MAL---------SLGADLHIQN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---RQNLTPL--------------------------TLAAFL----A------------------------K KEMMQ--------------------------------RIVEE---------ERTV-------NWTY------ --------------------------------------GRTQSAA--------------------------- -------------------------------------------YPLEHVDSIEP------------------ ------------------------TSGSI------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -NQKSVLTIA-------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ VYGEKVE----------------------------------------------------------H-----L SLLPH-LLE-----------QLVHHK--------------------------------------WI------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------A------------------- ---------------YGRKT-----------------LFAQLSMFCIYFICVTSCF-------------LLR PS---P------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------FERQQH---------------I-- ------ANDL----------------------------------------ICF-------------YDFKTR RFNE--------SAVSTIIYHLLHLICVT---------GATL-YL--VQA--------LLH-------IKNV GYHLYV-L----------GLSGFPAKAI----------------------FLFSCILMVITFFLRIF----- -----------------------------CLDE--------------AED--------IVW----IVIVLLT SLKFLFFCR----------------------------------------------GFKSVGP-FVLMLYKII IR-DLMRFFLIYLVIVVGF--SQAFYVIF----------------------LGY------------------ KRSDSGNR------------------------------------EPSIMSN-V------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------AES----- ---------------------YVRMFIMSLTEFTVFFEQLEEC----------------------------- ----------------------------------------EH---TVIGK----ITFVVYMLLVTLLLINML IAMMTNTYTE-VSGNSLEWLRQWSAII------------------------LMMEQSFDPATRLRYQR---- --RYGIRF-DGGE-----------------------------KLVLLL---------KDKMT---------- -EEE----------------FECQRK----------KMHEERR------------------KFREELRTNQR RRPV-------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------FICKQG----------------------------------------------- ------------------------------------------------------------------ANYFKS KHR--------------------------------------------------------------------- ---------------------------HTNNK--L------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------IIPTG--------------------------------------------------------- >Cele_OSM-9/1-937 ------------------------------------------------------------------------ --MGGGSS---------------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------------------RNK------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------TEPRGE------ ------------------------------------------------------------------------ ----------------------------------------------------------------GVKLAFDP DEKWSNLYR--------------------------------------------------------------- ---------------------------------------------EREKNHLYKWV---------------- ------------------------AVRKGGELINI------------------------------------- --------YERDGE---------------------------------------------------------- ------EGVLKF------------------------------------------------------------ ------------------------------------------AEEKLLTI---------------------- --------------------------------LYDE---------------------GQNPK-----LVTYS DYIKWKKGV--------------------------------------NVQLGLSEE---------------- -------------------------------------------------------------------SVDM- ---QQ------------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------SR----------------- --------------------------------------------FKE------------------------- -------------------------------------------------------------HY--------- ----------------------------------------ALWK---------------------------- ---------LNKRGVEG-------------------E----------------------------------- NLIHL-------------------------------------LLNR-------------------------- ------------------------------------------------------------------------ -----------------------------------EQQV--CYE-------IARILLK-------------- ---RF---------------------------------------PGMANDIYLGDEQF-----------GQS ALHLAI------------------------------------------------------------------ --VHDD------YETVSLLLN-----------------------------SKA------DVNARACGNFFLP EDFKLT---------------------NKI--T-----DYQGYAY--YGEYPLAFAAC-------------- ---------FGNKDIY--------DLLIQF-GAN-------------------------------------- ------------PN---------------------------------------------------------- ----LQDSFGNTIL--------HMCVI---------NYSSSMYS---------------------------- ------YAVR------HWAKPADPHVVN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---HAGFTPL--------------------------TLATKL----G------------------------R KQIFE--------------------------------EMLEI---------MKVE-------FWRF------ --------------------------------------SDMTCSA--------------------------- -------------------------------------------YPLNTLDTIQP------------------ -------------------------DGST------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -NYDSALMTV-------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ INGSTPE----------------------------------------------------------H-----L DMIGSEVIQ-----------RLLADK--------------------------------------WK------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------A------------------- ---------------FAQRK-----------------LIERLVLLIVQLITLSIVV-------------YIR PT---------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------E---------------------------------------LPRLYMEDPQ------WDD--- -----------------YIRTACELLTIL---------NCIF-FV-GYQQ--------LGE-------IRTQ GMRGYL-R----------NLKTAPAKAV----------------------FCIANLFLLLCIPFRLM----- -----------------------------KKHE--------------IEE--------ALF----VFALPGS WIFLLFFAR----------------------------------------------SAKLTGP-FVQMIYSMI AG-DMIRFAIISAIFLVSF--SQVFYFVG----------------------KDM------------------ DAKQKL------------EDTNPH---ACRISGY----------TIYTYNT-F------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------PET----- ---------------------FITLFRASMGGYD--YEEFSCA----------------------------- ----------------------------------------NY---QALTK----TLFVLYMFVMPIMMINIL IAMMGNTYTTVIAQAEKAWRQQYAQIV------------------------MVLERSVGKERLAASQL---- --EYSIRLDQEGS------------------------SGMEVRGLMVI---------KQTKK---------- -TRA----------------RQRKQA----------IYNWKTI------------------GRKVIHTIDKV GT--EQAVLLLHG-HDRLDRVYEDHVQPEKVPSRSRTPTRIGTT-------LNSSKRLKTTTMV-------- -----------------VGAAV-TN--------T-HEVRT-------------------------------- ------------------------------------------------------------------------ ----------------------------------------------DEAV----------NSMLLSAPPSLS G----------------------------------------------------------------------- ------------------------------------------------------------------------ -------------------------------EGATMDWQ-----------------PS-------------- ------------------------------------------------------------------------ -----------------ITPVEERSESKSQ-----------------------------------EDRSEAS TPNLGIHRTTPKAD----SPIRVVE----------------------------------------------- ------------------------------------------------------------------------ ---------YSRTIRVRAAD---------------------------------------------------- ------------------------------------------------------------------------ -----------------TI----------------------------------------------------- ------------------------------------P----------------------------------- -------------------SIEL------------------------------------------------- ------------------------------------------------------------------PNIPTK QTS--------------------------------------------------------------------- ---------------------------STPPH--RAVSPRLRA-DM--------F----RRHQQPAS-FDQS ---------------P-------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------PLPPTNDKSE---------------------------------------------------- >Cele_PKD-2/1-716 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------MN--------------------- ----------YGAADER-WAN--------------------------------------------------- ------------------------------------------------------------------P----- ------------------------------------------------------------------------ ----------------------PQP----------------------------------------------- -------------------------------------------------------------------VAAAE HGPS--------------------------------------------------------FDHSMVSEEY-- ---EHDKKKNP------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------AQK---------------- ------------------------------------------------------------------------ --------------------------EGI------------------------------------------- -----------------------------------------SFS---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------QA--LLASGHEKSDGKIKLTA--RS-------FME VG-----------------------------------------GYAVFLIVLVYVA-----------F-AQN SIQSYY------------------------------------------------------------------ --YSKVM------S--DLFV---------------------------------------------------- -----------------------------AS-TGA--------------SGAP------------------- ----------AFGSCT--------SM---------------------------------------------- ------------------------------------------------------------------------ ------------------------------------DNIWDWLS---------------------------- ------QVLI------PGIYWT-------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------ETSNST----D------------------------N ENMI---------------------------------YYENR-L--LGEPRIRML----------------- ------------------------------------------KV------TNDSCTVM---KSF-QREIKEC ---------------------------------------------FANYEE--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------KLEDKTMVG--DG--SVDAFIYATAKELENLKT--------------- VGTIASY----------------------------------------------------------------- ---------------------------------------GGGG---------FVQRLPVAGSTE-A-----Q SAIA----------------TLKANR--------------------------------------WI------ ----------------D-----RGSRAIIVDFALYNA-NINLFCVVKL--LFELPA---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------SGGVI--------TTPKLMTYDLLTYQTSGGT--RMMIFEG---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------IFCGFIL-YF-------IFEELF-AI--GRH---------------------- RLH-YL-T----------QFWNLVDVVL-------------------LGFSVATIILSVNRTKTGVNRVNSV IENG----------------------------L-------------TNAPFDDVTSSENSYLNIKACVVFVA WVKVFKFIS----------------------------------------------VNKTMSQ--LSSTLTRS AK-DIGGFAVMFAVFFFAF--AQ-FGYLCF--------------------------G--------------- -------------------------------------------TQIADYSN-L------------------- --------------------------------------------YN-------------------------- ------------------------------------------------------------------S----- ---------------------AFALLRLILG-------DFN------------------------------- ---------------FSAL--------------------ESCN--RFFGP----AFFIAYVFFVSFILLNMF LAIINDSYVEVK----AELARKKDGEG------------------------ILDWFM--------------- ----------------------------------------NKVRG-------------------------LT KRGK----------------RP------------------------------DAPGEDA-TYEDYKLMLYRA GYA----------------------EKDINEAFTR------------------------------------- ------------FNVTSMTEHV-PEKVAEDIAD-EVARMTEQ------------------------KRNYME NH---------------------------------------------------RDYANLNRRVD-------- -------------------------QM------------QES--VF---------------SIVDRIEG--- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------VNAT----------- ---------------------------------------------------------------LQTIEKQR- --------------------VQQQ----------------DGGNLMDL----------------SALLTNQV RNRESAARRPTITS---------------------------IADKKEE------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Cele_TRP-1a/1-1027 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------MTKEG----------M----- ------------------------------------------------LSA--------------------- ----------AGRRFSR-CA---------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------PSPRPRRN-------------------------------Y-A-----LANI- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------PPPAAVHIR---------------------------------T- ---------NDMISPE--ER---------------------------------------------------- -------------------------------------RF--LEAAELGNKPTLQECLD--YDGDR------- -----------------------------------------------RLNVNCLDS-----------M-GRT ALEIAV------------------------------------------------------------------ --DNENM------EVVELLLQQ------------------------------------PDI----------- -----------------------------RI-G-----------------NALLCAIR-------------- ---------EGVYRLV--------EVLVNH------------------------------------------ ------------PN---------------------------------------------------------- -----------ITR--EMLGD-----------------GWSQAL---------------------------- ------DP---------SEAASAEYSSDI------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------SPV--------------------------ILAAQL----N------------------------Q FEILQ--------------------------------MLIRK-D--ASIEKPHRH----------------- ------------------------------------------SC------ICETCDRE-RLNDS-LQYSLKR ---------------------------------------------INTFRALAS------------------ ------------------------------------------------------------------------ PAWMSLTSP----------------------------------------------------------DPI-- ------------------------------------------------------------------------ ---LSAFKLSWDLQRLAF------------------------------------------------------ -----------------------EEHEFKETYL--QLSEQCKQYSCDLLSQCRSSEE--------------- VIAILNK-----------------------------------------DGN--------------------- VNDDNIDVWA---------------------------------------SKLSLSRLKLAIKYE-Q-----K AFVSHPHCQ-----------QLLTSI--------------------------------------WY------ ----------------EGIPYRQRSGTWANFFLYAF--LLFLWPIFCL--MYILMP---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------KSRLG--------RLVRSPFMKFFYYSVSFATFLGLLTWATFE-----------DYR YEKGER--------------------------------------------GG-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------MTRA----------------------------------------------------- ------SDRGPPATWVESLVFTWVIGMLW---------SEIK-QL--WEE---------------------- GFKRYM-R----------QWWNWLDFLM-------------------ICLYLCTISIRLSAYYIFTYREDP- ---------YRYTV-----------------RT-------------YWTSEEPMLVAEALF----AVGNVFS FARIIYLFQ----------------------------------------------TNPYLGP--LQISLGCM LV-DVAKFCFIFVLIISSF--SIGLAQLYWYY-DPNTDVCLPGA---------------------------- ----T------------------------------------C----KHSSN-V------------------- --------------------------------------------FSSIAD---------------------- ------------------------------------------------------------------S----- ---------------------YLTLLWSLFSITK--PEDTD------------------------------- ---------------VVEN--------------------HKIT--QWVGQ----GMFIMYHCTSIIVLLNML IAMMSHSFQIINDHADLEWKFHRTKLW------------------------MAHFDE--------------- --GSSLP-------PP--------------------FNIIVTPKSLIYVMNCLFNTVRWLLG-------KYT YQKN----------------RNRATIR--RPGYSRKRNEMEKSGGH------DDDSLKPLTYADIITRLVA- --------------------------RFIHQTKKD------------------------------------- ------------MKMDGVNEDD-LHEIKQDISSLRYELRDDR------------------------RREIVR SSSHIDA----------------------------VKRDIMR---------TMSTTSR-------------- ---------------------------------------------R----------------PYGGSMR--- --LP-------------------------------------------------------------------- -------------------------------------KTRP--------------------SVAEESEED-- ---------------------------------DKSDETSSTD--------------EEAD----------- ---------------------------------------------------------------ETRSRKSSV ---LYIPPVN--------------------------------STLPG--------------------IISEE APVKKSTKRRA-SE---------------------------ADSKLPD------------------------ ------------------------------------------------------------------------ -------------RPLSDT----------YTSS--------------------------------------- ---------FTPKL--------LPV-FA----------------------------Q--------------- ------------------------------------------------------------------------ -----------------------------------PP----------------------------------- ------------------------------------------------------------------------ ----------------------------------------HSALRKTDTSM--------------------- ---SFP------------------------------------------------------------------ --------------------------INGTAL--DTSI--------------------------VKP----- ---------------P------------------------------------------------------RG V----------LRASQENLPAVELIE---------------------------------------------- --------------------------------------------------------TL-------------- ----------------------------------------------KKEMNEKL------------------ ----------------------------------------------------DRLISG-------------- -----ISENVKSP-----SP----------------------------ASHSHV----GFNVEK-------- >Cele_TRP-2a/1-816 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------M-------------------- ------------------------------------------------TSS--------------------- ----------EASEFRM-IED--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------DDDVS------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------NNV---------------- ------------------------------------------------------------------------ ---------------------T-------------------------------------------------- ------------------------------------------------------------------------ --------WTE-------------------------SD---------------------------------- NS---------------------------------------------------------------------- -------------RLR--EK---------------------------------------------------- -------------------------------------QF--LLSCERGDIGSVRKLLA--GISTE------- -----------------------------------------------TFNINCLDP-----------L-GRN ALLIAI------------------------------------------------------------------ --ENENI------EMIELLL-D------------------------------------HNI----------- -----------------------------ET-G-----------------DAILYAIG-------------- ---------EENVEAV--------EIIVEH------------------------------------------ ------------LE---------------------------------------------------------- ------------KM--DKFDS-ERQGVEI------------------------------------------- ------T-------------EHSAFTPDI------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------TPI--------------------------VLAAHK----D------------------------N YECIK--------------------------------LFLDK-K--GTVPHPHDV----------------- ------------------------------------------RC------SCPECYVA-REEDS-LRLSRSR ---------------------------------------------INAYRALTS------------------ ------------------------------------------------------------------------ PSLICLSAR----------------------------------------------------------DPI-- ------------------------------------------------------------------------ ---LYAFELSWELKRLSF------------------------------------------------------ -----------------------IENEFRTDYE--ELSQKCQKFCVHMLDQVRGSKE--------------- LEVVLNH-----------------------------------------TTN--------------------- --AWH-DVTS-----------------------------ANYG------NPEKLARLKLAIQLS-Q-----K RFVAHPNCQ-----------QLLLDI--------------------------------------WY------ ----------------EGVESVRCTNFIYKLIFYIL--GMLSFPLFSL--VYLLAP---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------HSSMG--------QFAKKPFIKFLSHSGSYIFFLILLIMAS--------------QR MNV--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------MVGKE---------------- -------------------------------------------------KK--------------------- ----------ESTRLKL-SAI--------------------------------------------------- ------------------------------------------------------------------------ --------------------------------------------KEYLG----------------------- ----------------------------------------------------------KY-R-----GVDA- ------------------------------------------------------------------DNNEGY DGHQK------------------------------------------------------------------- ---WHENDQVV------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------LQA---------------- ------------------------------------------------------------------------ ---------------------M-------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------AYF--YKAVKSKLYSEVRSFLG--ILLPHGP----- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --DDGRL------SSLQSLLMD------------------------------------TSS----------- -----------------------------EE-S-L--------------KEALLLSIA-------------- ---------VGSRPLV--------EFVL-------------------------------------------- ------------------------------------------------------------------------ ----------------VLFVD---------------APYLERSG---------------------------- ------SA------------NSPHFPPHM------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------TPL--------------------------MLACIL----N------------------------N FSIVQ--------------------------------CLITR-G--HCIQIPHFI----------------- ------------------------------------------TC------ECKTC----KRETV-TTHSSTR --------------------------------------------LVDVMRALSS------------------ ------------------------------------------------------------------------ EAYLWLATD----------------------------------------------------------DVF-- ------------------------------------------------------------------------ ---AATCAVARDLQQLASD----------------------------------------------------- -----------------------DQLEYVETYR--DLEMNVQRFLCRISDQAWRVDE--------------- FNMMVANR----------------------------------------NYC--------------------- --PER-------------------------------------------MTEISSPRLQMAMDSQ-M-----R QFTCSTNSQ-----------TTIKSVFRS----------------------------------DWY------ ----------------N--YGIKPKRDAWRFLR-----ACILMPFLVM--LHAFMP---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------TK--G--------TTMCVPLARFIAHITMYLVFLIAAILRPTIG-----FYFAWTDS IEVTVQ--------------------------------------------AL-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------EIFMYAYVMGLAL---------EKGI-LF--YRV---------------------- GRDGFF-A----------FWWRWFDAAL-------------------IFIFLFSLIFFTGKWGKREAFDPS- -----------SVD-----------------RM-------------HWPSFEFSLLHEICL----AIACVLS ILKCFYYAQ----------------------------------------------MMKSIGG--SVISVGKC VG-KTYTYILIMVAIIVSF--SVGLNIIVDPYLNRSTMKI----------------GD-------------- -------------------------------------------QDYTKTTD-S------------------- --------------------------------------------YETIGT---------------------- ------------------------------------------------------------------S----- ---------------------SKNLFWSIFGYLG--PSTFT---TV--------V----GNTGPN------- --------------MDPVK--------------------HTLN--SSTFE----ILAAVYHGILIITVLNLM TSILVKGADEVLDNEEMEFKFTRAAIY------------------------SEFLSW--------------- --EMAAP-------PP--------------------LNLILVVAHFVH-------------R-------NLL KRYY----------------ASPA------WGEKPANDDVEDQA-------------ADEQYMQLLMVVFA- --------------------------RFVASKECK------------------------------------- ------------YK-----------------SIWRSEF---------------------------------- -----------------------------------------------------HREEKQPPRVT-------- -------------------------FL------------TTG--AHSF------------------------ ------------------------------------------------------------LMDNTF------ ------------------------------------------------------------------------ ---------------------------------------------------------EGFK----------- ---------------------------------------------------------------MRSSRTMEA --------------------EGYK----------------EYTTV--------------------QYYVPKS KTPGPAAAADA-GT---------------------------KVAPKDDKPQNN------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------PV-LARTGI---------------------------------------- ------------------------------------------------------------------------ ----------------D------------------SPVP--------------------------------- -----------------------------------------------------------------------S SKQVM-----------------------------------------------------SSELSA-------- ------------------------------------------------------------------------ -----------------------------------------------------------------SI----- ---------------P-RARDV-T---------------------------------------------FLG V----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Cele_TRP-4/1-1924 ------------------------------------------------------------------------ --MDSPRGGILGRALREASQSTRQENDVDMDQVPVRQMNRDYGGSRRTQMNPHTSQPGPSHVSIVNVPERGG PTSSTSTTHETEHTAHRTESGRFIRRRRQSREVTTTTTRPYDPAPPTQTRTSSGSTVNGWGENRPKSADEEI KRRRRSGGGILSRGLREMNKMVEELEQASEEPSTRKGILGTALKDMEG------------------------ ----------------------------TTYQKIYRKREETP---KRSRSFDDQEMSNR------------- ---------VGMIEHLL--------------RDKDPLELQQLGLTDLL-----TTDTIPTDRPPLRRSSTHL QIGKNSRIIFVPKQPSRDSVTPPDRLLGKPLFRESLTSHASSHEEMSSEDLA----------MADPQTK-IL YFAKRDEWA-----NVESEIETIKRSDFSMA--------------DNHGFTAFLLAVKAGK---DQIV---- DKMIRKGARVDYSTKDGRNATHIAAMYS----GVETLELILKRYSELLRKGAGPKKQLAIHVACERKSKKAF PIVKRILEDT--DQRMAED-------------GDGSLPIHLAFKFGNVN-IVELL--L-------------- -------------------------SGPSDEQTR-----------KA-DGNGDTL----------------- --------LHLAAR---------SGNIEAVRTAIAAGC---------------------------------- ---DNANVQNRV---------------------------------------------------GRTPLHEVA ---------------------------------EVGDQN--------------------------------- -----MLKIMFKLR----ADANIHDKEDKTP-VHVA-AER-----------------GDT-S--------MV ESLIDKFG-G--------------------------------SIRARTRDG--------------------- --------------------------------------------STLLHIAACSGHTSTALAFLKR-GVPL- ---FMPNK---------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------KGA--------------------------------------------------------- LGLHS---------------------AAAAG-----FNDVVKMLIA--------------------RG-TN- ---------VDVRTR---DNYTAL---------HVAVQSGKASVVETLLGSGADIHVKGGELGQTALHIAAS LNGAESRDCAMMLLKSGGQPDVAQMDG--------ETCL--HIAARSGNKDIMRLLLD-----ENADSKISS K-------IGETPLQVAAKSCNF---EAASMILKHLSEVLTQEQLKE--HVNHRTN-----------D-GFT ALHYAAEIEQ-------------------------------------------------------RQLH--- -FPGEDA------KLVNLLID-----------------------------YGG------MVEMPSLNANETA MHMAARSGNQAVLLAMVNKIGAGAVQIVQNK-Q-----SKNGW-------SPLLEACA-------------- ---------RGHSGVA--------NILLKH-HAR-IDVFDEMGRTALHLAAFNGHLSLVHLLLQH------- --------------------------------------------KAFVN----------------------- ----SKSKTGEAPL--------HLAAQ---------HGHVKVVNVLVQDHGAALEAITLDNQTALHFAAKFG QLAVSQTLL---------ALGANPNARDDKGQTPLHLAAENDFPDVVKLFLKMRNNNRSVLTAIDHNGFTCA HIAAMKGSLAVVRELMMIDKPMVIQAKTKTLEATTLHMAAAGGHANIVKILLENGANAEDENSHGMTALHLG AKNGFISILEA----FDKILWKRCSRKTGLNALHIAAFYGNSDFVNEMLKHVQATVRSEPPI--YNHHVNKE FSTEYGFTPL--------------------------HLAAQS----G------------------------H DSLVR--------------------------------MLLNQ-G--VQVDATSTT-------MNV------- --------------------------------------IPLHLAA------------QQGHIAV-VGMLLSR STQ-----------------------------------------QQHAKDW-R------------------- --------------------------GRT------------------------------------------- --------------------------------------------------------------------PLHL AAQ------------------NGHY---------EMVSLLIAQGSNINV-MDQ------------------- -NGWTGLHFA---TRAG---------------------------------------HLSVVKLFIDSSADPL AETKEGKVPLCFAAAHNHI------ECLRFLLK--QK----HDTHQLMEDR--------------------- ---KFIFDL------------MVCG----KTNDNEPLQEFILQSPAPIETA-VKLSALYRDMSEKEKERAKD 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------MSKKSL GLDVRLELE-----GLISNDDTIR-------------------------------SEKDGR---QASI---- FRVAELDARTEADN-----------------------------------------LRSIIH----------- ----------------------------------------QSAREGNVN-ALQEA----------------- -------------------------LLKAPLAVN-----------AQ-DGDFMTP----------------- --------LHYAAR---------YGNYDAVKLLLSKNA---------------------------------- ----LPNTKNRE---------------------------------------------------GDTPLHIAS KYIYGYS---------------------DICSIIDEDQA--DSARKYN---TATKK---------------- -----IINALVSEN----AEIDPVNKYQLTP-LHYAAMKS-----------------NFS-A--------LH ALIKLK---A--------------------------------DVDAEDDNK--------------------- --------------------------------------------MTPLLLACVHGSQEIIQELIKA-NSNV- ---TKRDQ---------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------RLN--------------------------------------------------------- TVFHI---------------------VALRG-----EPEYLEMMMD-----HDPV----------------- ----EAIKALNLFNN---EKKTPL---------RMAVEGNHPETLK-------------------------- -----------KILQMEKKNSCKWMDR--------EKELI-HFAAEKGFLEVLKALVE-----AGG-----N K--------------------------------------------------NELNE-----------V-KAV PLHVAAQMNQ-------------------------------------------------------------- ------L------EVVSYLIE-----------------------------EEK------DN----------- ----------------------------IDV-V-----DEQGL-------TPLMMAVT-------------- ---------HDSKKCV--------EYLIAK-KAN-LTITDKDERTPVFIGAKFNALSSVEYILDHLRKKNKE TERSALKSPT----------------------RNTLRIVSEDVRRTMVN----------------------- ----MVDRDQNTPM--------HIVAS---------NGYLEMMQ---------------------------- ------LLQ---------KHGASITQVNEDEETA-------------------------------------- ------------------------------------------------------------------------ --------------------------------LHRAAIGGQTGAVRQLLEW---DIR------------LLL MKDEMGNSAL--------------------------HLAARS----G------------------------H DATTK--------------------------------VLLDN-G--ADKE-AKNS-------YQK------- --------------------------------------TPLQVAV------------DSGKLET-CQRLVAK GAQ-----------------------------------------IESSSDT--------------------- ---------------------------KT------------------------------------------- --------------------------------------------------------------------VLHT AAF------------------YGNE---------SIVRYFIAEGVTIDR-RDE------------------- -EGKTAFDIA---CEND---------------------------------------HKDVARAFLETDQWKN LMIP---CDVIPLDKHRNPVNMKRRTPFRTLLT--KF----PELASFVMDNCIEKSKE--------ETDSTQ -SVAYNFEF------------LDDTYMMRCVSDDGTGEQLIGCKSA-------------YDEDFKLEKDAQS YASNYDR----------------------------------------VYKYHPLKL---MADAE-K-----L HLLNHPLSK-----------ALLKYK--------------------------------------WN------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------R------------------- ---------------LGRPM-----------------YYFALFMYLVFIVSLTQYV-------------RHT K----------------------------------------------------------------------- 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VGLAVDDIKGVQEKAELKRLAMQVDLV------------------------LQIEASL-------------- -------------------------------------------HFFI----------QRTKK---------- --YA-----------------------------------------------------------TCR------ --------------------------YATFPYGKL------------------------------------- -------------HKTGFAGWW-SNFRRR------FGLSVS------------------------------- ------------------------------------------------------TDPEIDEM---------- ------------------------------Y------EREAE--FTS------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------EMTQK----------------------------------- ------------------------------------------------------------------LQNQ-- ---------------------AAKLK-----------------NI--------------------QENIDVM ---------------------------------------------YEKQVRL-------------------E AI---------------------------------------------------------------------- ------------IAKLATG----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------LNIN------------------------------------------------ --------------------------------------------------------------------IELE EKD--------------------------------------------------------------------- ---------------------------N-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------FSRNLFKD--------------FLITIFTGIFFMFLVLKGT---------------- ------------------------------------------------------------I----------- -KARI------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------TKSVSTWFIVAFCFNIFTYM-------ATLA-YV-WLPTVF-------------------- GYDDYH-L----------EVKKIVTWFL-------------------------------------------- -----------------P-----------------------------------------------IIAIISA WANLLYIMR----------------------------------------------KSP-FGI--YIFMMTRI LR-SFAHIATIWIPTLIAF--SFAFLLIM----------------------RDT--G---------VKPWPL IDQQT--------------------------------------ENMTMVQTML------------------- ------------------------------------------------------------------------ --------------------------------------------------------------VILQA----- ---------------------VTKTSTMMIGEVD--ANDILDT---------------------------N- ---------------------------------------------QWIPS----ILVLVFEIITVILLMNLM VSLAVGDVTYLNNTAQDKLLKIKVNFV------------------------IEALQISEQFQNEMFRL---- -HTKKTP------------------------------------NVLVI-----NSDGTYISE------FDVF PHSA---------------------------SVAISDEAFKISFMETGM----------------------- -------------------------RLRIKTSKGR------------------------------------- ------------VKTATVSKCD-IECIES------------------------------------------- ------------------------------------------------------------------------ --------------------------------------------TES------------------------- ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------MVKFLLD-----------------------------NGA------NYHERCLGNFMCP EDQKTSRMDS---------LDHEWVDLCLQ--T-----NYEGYVY--WGEYPLSFAAC-------------- ---------LGQEECY--------RLILAK-GAN-------------------------------------- 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Csap11071768_TRPA5-1/1-1006 ---------------------MRMNGSQ-------------------------------------------V SFLQSGNS---------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------ASPWL------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------ATNNGNVQKLI-A-------------- ---------------------------------------------ANRRKCNAALEC--------------- ------FRWNKAG---------AQPELTLLPSMSPTGSP--------------------------------- -LKYWKFVKDGA---------------------------------------------------AMSRIQ--- ------------------------------------------------------------------------ ----------------------------------------------------------VE-E---------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---EESRST--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------EAM--------------------------------------------------------- PLIFV---------------------AIQSG-----DVEEVKDELKDDP-----------------ET-TL- ------------------NTR------------------------------------YGG------------ -----------------------------------ALPL--HMACHARRLDMLTFLLQ-------------- --------------------------------------------AGA--KVDAMEG-----------L-GQT ALHLAVFYAW-------------------------------------------------------------- ------H------NGVETLLK-----------------------------HGA------SPNTLCE------ -----------------------------PP-P-----GVKGL----RIETPLHMAVR-------------- ---------RGDLPST--------VLLLQH-HPD-LKQRDSDMCSILHLAALSRSLELVRQILKE------- -----------------------------------------KEVREMIM----------------------- ----SKESKGNSVL--------HMALM-TECDAVCEATIHDLVK---------------------------- ------ELM---------QAGADINHVN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---LQGESPL--------------------------FFAAKH----R------------------------L SRVVE--------------------------------TLIGF-G--ADVT-VVTR-------SGQ------- --------------------------------------SLLHAAC------------LEGCATS-LDHILKT GQVQ---------------------------------------NLVTKCDK-D------------------- --------------------------GNA------------------------------------------- --------------------------------------------------------------------PFHY AVQ------------------SGSI---------DCCELLLINGDHLTR-LNK------------------- -DGLTRCAVI-------------------------------------------------------------- -------------------------------LR--QLP-SATQLLTRLFDNHVLLSNV--------PHHDPN FRVSFDYSV--------------------------------------------------------------- ITLE-EG--------------------------------------------IQTSLISELSSSR------VE ALLKHPLLE-----------SFLYLK--------------------------------------WN------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------R------------------- ----------------IKPF-----------------FYCTVFFYLLFLLLHTTFI-------------V-- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----MTFGKKTLGWERNPD----------------------------------------------------- -----------SYTVFLVLHVTMFLLIMF---------PDLV-IM--FA----------------------- NLKKYL-Y----------QWETYTKIIA----------------------LTSSAFVVF-NCFPLIKHTDSL PS----QGQSMNTS-----------WENSS--E-PSANEINTMMSPEVVR--------YAA----AISAFFS WVEFMMLLG----------------------------------------------RFPSLGS--YVLMFTRV AR-SIIKFLAAFSSLIIGF--SVSFLVLF----------------------PK------------------- --KDD-------------------------------------------FST-L------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------PLS----- ---------------------FTKTLMMMIGEID--FGNLIHD----------------------------- ---------------------------------------LD-----FLSG----VFLVVFLFLVCILMTNLL IGLAVNDLPDLQRQGKIRRLSKQVSYV------------------------VSYERLMVVARNLFCF----- ------P------------------------------------RQLRI---------FLTQR---------- --CK-----------------------------------------------------IPQ--SVDV------ --------------------------FPNKSNSYRISRRS-------------------------------- -------------SHYPIPTET-LQEAIL-LGN----------------------------EDSKIDFNAMQ EEDTF---------------------------PMQFRS---------------------------------- ------------------------FKIKYDRDRQQMQHRLAQ--LPD------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------ITTTET---------------------------------- ------------------------------------------------------------------MLKE-- ----------------RLDRMEQTIQY----------------QV--------------------LHL---- ------------------------------------------SLQLQKHQFVC---------------SNCK QLLPRAQTR------------------QWQTI---------------------VPKNN-------------- -------------QSINATQSCPVQ----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------PLAKNRF---------------------------------------------- --------PGQA-----------------------PQSMPAMRSGSQITP--------------GNMTLQT- --P--------------------------------------------------------------------- ---------------------------QQYPY--AF----------------------------------TD ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Csap11150858_TRPA1-like/1-1131 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------MI--------------------ESPYRVLKVAAKGDVE-QLRKM----------------- -------------------------CLDDPTKLT-----------LK-DRRGWTV----------------- --------AHHAAA---------HDRPHALVFLHNQGA---------------------------------- ----DLEAKDDN---------------------------------------------------GDTPFHVAV ------------------------------------------LKEALE------------------------ -----ALDTLLDCG----VSTSITNLQGDAP-IHVA-INN-----------------NKI-S--------VV NLLTRRHQHV--------------------------------DLFQKDSRG--------------------- --------------------------------------------RTPLHLAAHYDFAQCAKAMLESPGFNK- ---CPNEA---------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------CN----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------YGY--------------------------------------------------------- HPIHL---------------------AARNA-----SIGVLEALLK--------------------FA-DSR GC--IREKMITIPDL---EGNVPL---------HLAVHGGEIKAVE-------------------------- -----------LCLRNGALISTQQHDS--------STPV--HLACSQGSYDIVKLMFT-------------- ------LQPQEKKKALATQDAQG-----------------------------------------------MS PLHCAAMFDH-------------------------------------------------------------- ------P------QLVSFLLD-----------------------------EGA------DI----------- -----------------------------DM-V-----DKEHR-------SPLLLAAA-------------- ---------HRGWRSI--------DILLSR-GAD-LTIRDTNHKNILHVVVISGG--CLIELLSLS------ ---------------------------------QAQESWWKSRIAHMLN----------------------- ----EQDSLGWSPL--------HHASR---------AGQISSLA---------------------------- ------YLL---------RLGASVRTKDKRDESP-------------------------------------- ------------------------------------------------------------------------ --------------------------------LHFAAKYGRYNTVRQLVES-------------PNGFLILN ECNDEGKTAL--------------------------HIASGE----G------------------------H TRVVR--------------------------------LLLGK-G--ALL--HRDH-------QGR------- --------------------------------------TPLHLAA------------EGGHLAT-LTAILAV HSH-----------------------------------------TLDQTDK-E------------------- --------------------------GNT------------------------------------------- --------------------------------------------------------------------PLHL AVC------------------ANKP---------EVVSQLMTLNCKLIE--NN------------------- -SQCTPIDIA---LHYK---------------------------------------LFEASLALVTHPRGPK --------EVLSTSSNMNG------CICMALIR--IL----PRVFEAVLDQAIVRANV--------KETSKD FFIKYSFYP------------F--------------------------------------EMNKEQLEGERL RKKDPK------------------------------------------FRPLPLYACNAMVDCR-R-----V DLLMHPLTQ-----------TFLEMK--------------------------------------WR------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------A------------------- ---------------YGKYI-----------------HLSFLIIYLVFLFLVTFFA-------------LGY LG---------------------------------------------HSIHMVS------------------ ------------A----------------------------------------------------------- ------------------------------------------------------------------------ -NY-TSTSTSYILYDST-TPCTPHF-------------VYEPQEASG------------------------- -----------CIYFSAVAILVFAMLNII---------KEMV-QL--YH----------------------- HKLKYL-A----------EGINVVEWTM----------------------YLTSTCMVLPVIV--------- -----------------------------------------GGEWKAQQF--------NSA----SLAVFTA WFTLLLYFQ----------------------------------------------RFDRIGI--YIVMFLEI LN-TLIKVLLVFSVLIIAF--GLAFYILM----------------------YP------------------- GSHLS-------------------------------------------FSS-V------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------PMS----- ---------------------VMHAFSMMLGEVD--FLNIFVYPYFG------------ESTK--------- ------GDL------L------------------------LF---PVTTF----ALLLIFMILMPILLMNLL IGLAVGDIESVKKNAQLKRIAMQVEMH------------------------TDLENKL-------------- ------P------------------------------------EMLI----------QRVNK---------- --TE-----------------------------------------------------------VLV------ --------------------------YPNAV-CG-------------------------------------- ------------------PNWI-HRILGA------LNFACP------------------------------- ----------------------------------------------------MNASKDAE------------ ----------------------------------SEAQESKS--AEE------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------YLFEE----------------------------------- ------------------------------------------------------------------IEDQ-- ---------------------KKHLK-----------------EM--------------------SGV---- ---------------------------------------------LDQQTKL-------------------- ------------------------------------------------------------------------ ------------LRLIVQK----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------MEIR------------------------------------------------ --------------------------------------------------------------------SEAD ECD--------------------------------------------------------------------- ---------------------------EGVSL--EEII---------------------------------- ------------------RAPSIT------------------------------------------------ -------------RRFHSS-SA-VRRI--------------------------------------------- ----------------------------------------------------PVAKKDL------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Csap11252094_Iav/1-1179 ------------------------------------------------------------------------ ----MGAC---------------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------------------ATK------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------KQAINP------ ------------------------------------------------------------------------ ----------------------------------------------------------------GSAL---- DLVISQAS---------------------------------------------------------------- ----------------------------------------------SDDCVLYRLA---------------- ------------------------DYKKGGRLIEE------------------------------------- --------YTRGGG---------------------------------------------------------- ------KEVERL------------------------------------------------------------ ------------------------------------------ILEEFGVF---------------------- --------------------------------MYNH---------------------GRG-K-----EITRT EYLKWKYRKV------------------------------------PKDQMVVHIN---------------- -------------------------------------------------------------------TDKK- ---SPFDPL--------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------HK----------------- --------------------------------------------WKD------------------------- -------------------------------------------------------------HE--------- ----------------------------------------ACWQ---------------------------- ---------MQFRGSLG-------------------E----------------------------------- TLLHV-------------------------------------LIMC-------------------------- ------------------------------------------------------------------------ -----------------------------------DTKA--HTR-------VAKILLR-------------- ---CF---------------------------------------PRLCVDVVEGEEYL-----------GAS ALHLAI------------------------------------------------------------------ --AYGN------NELVTILLA-----------------------------CGS------NVHQRAIGSFFLP RDQQVTVPP-----------------GPAN--T-----DYEGLAY--LGEYPLAWAAC-------------- ---------LGNETVY--------NKLLDY-DAD-------------------------------------- ------------SN---------------------------------------------------------- ----AQDNFGNMIL--------HMVVV---------CNQLGMFS---------------------------- ------YALR------HPRQPAQDGIMN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---EAGLTPL--------------------------TLACRL----A------------------------R STIFK--------------------------------EMLEL---------TCIE-------FWRY------ --------------------------------------SNITCSA--------------------------- -------------------------------------------YPLNALDTIRP------------------ -------------------------SGET------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -NWNSALMII-------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ LNGTKSE----------------------------------------------------------H-----L DMLEGGIIQ-----------RLLEEK--------------------------------------WK------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------T------------------- ---------------FARNQ-----------------FLKRLAIMLLQLILMSGSV-------------YLR PCYCGP----------------------------------------------R------------------- -DMDK----------------------K---DEVVR------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------MKLYN--------DFFDND-- -----------VKSI---TRYCFEAGTLA---------GVIS-YV-VFQQ--------GEE-------MMNQ GIASFM-R----------GLAANAPKAI----------------------FLFSNLLIMLCVPCRISYYFSV -------------------------DKDTTFRF--------------IED--------ELL----SYAVAGS WFMLMFFAG----------------------------------------------ALKLTGP-FVVMIYKMI SG-DMFTFSIIYGIMLVGF--SQAFYFLN----------------------KHP------------------ KMDKE-----------------------------------------SKYAS-Y------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------HST----- ---------------------WMALFHMTLGDYD--YSAMDQN----------------------------- ----------------------------------------IY---SGMSK----FVFLVFTIMLPIMLLNML IAMMANTYSTVISMSEKEWVKAWAKIV------------------------IALERAISQEKAKDYLY---- --MYSIPLGGGGD------------------------GGEESLGVMVI---------KSKDK---------- -TKA----------------KQRKGA----------LSNWKRV------------------GRVTIDALKRR GVSGEFLRREMWGLQTAAS-------TPVKGPAKKKGYGNF----------LGTDNGPGTVDILGDALDQTR FA-TDGVDVDPDNEMDGFG-AL-TGAIDQ-LAFT-HDLDF--------------------------SGDGVD DDPLKP----------------------------RV-ATDVPGAG--------------------------- -----------GHTRSSIMGAPAALQA---KKKLKKKKEFDG--HDNPAFLD-------DEELLLAAALGTE G----------------------------------------------------------------------- ------------------------------------------------------------------------ -------------------------------PGAESDDS-----------------DTDMLE---------- ---------------------------------------------------------------ARRLAQP-- --------------RIVIQ--AET------------------AAV--------------------VSNVGAT APTAAAKGKAA--------------------------PKPAGTVAPKDAKKTPTQ---------ATPVS--- -----------------------------EILGRPRL----------------------------------- --------PSAKIRRIGSAR---------KTPARFT------------------------------------ MTFTEKY--DPVKP--------------SPGAPQ-RQMTTDGQGAAPSDPADKGKK---------------- -------------------------------EVKEKPKDKDKDKT--------------------------- ---------------KEK--TKDSAKEDKPSMVEEEPA---------------------------------- ------------------GEEEE------------------------------------------------- -----------------------------------DESGD-KWAEKK-------------------PRRSTN KVA------------------------------------PSDS----------------------------- ---------------------------AE-----SGAEGRARD-DLSVGL--------------QSG-ADTT ---------------R-QEVRA-------------------------------------------------- -------------KERERPKTSVASQ---------------------------------------------- ----------------------------------------------------KMKKR--------------- --------------------------------------------------ATDDVGNMNS------------ ------------------------------------------------------------------------ ----------ILPWDNEDGDIK-------------------------------------------------- >Csap11291943_TRPC/1-1249 ------------------------------------------------------------------------ --MPA------------------------------------------------------------------- ------------------------------------------------------------------------ --------IRGVE---------------------------------ADVEEIKL----------KD------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ NCNNSRAN---------------------------------------------------------------- ----------------------------------------------SIARALKKKI----------S----- ------------------------------------------------LTR--------------------- ----------LTSRTSL-VA---------------------------------------------------- ----------------------------------------------------------------DRED---- ------------------------------------------------------------------------ ------------------RERERRPSRE------------------------------RY-P-----TFTIE DWEEGEH------NGAFREDMLFKDDF--------------KGEDKSEGDV---------------DTDIGD DPDGE---------------------------------------------------------GTSLV----- ---DNEDIRSV------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------SSS---------------- ------------------------------------------------------------------------ ---------------------KRASQLSV------------------------------------------- -----------------------------------------DHS---------------------------- --------MVRCGR----AKFFKRLSVCDLK----------------------------------------- ----------------------------------------------------------------------D- ---------GHMMDPK--ER---------------------------------------------------- -------------------------------------VF--LEAAERGDKHTMMRCL----SPPS------- -----------------------------------------------AVNVNCTDI-----------L-GRS AIQIAV------------------------------------------------------------------ --DNENV------EIVELLLLQ------------------------------------ENV----------- -----------------------------KI-G-----------------DALLYAIT-------------- ---------EGVYKIV--------EMLINH------------------------------------------ ------------PS---------------------------------------------------------- -----------ITP--EMLAN-----------------DWVKVR---------------------------- ------AG---------GE-ESSDFDPNI------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------SPI--------------------------ILAAHC----N------------------------Q FEILQ--------------------------------LFLSR-G--AYIDKPHPL----------------- ------------------------------------------SC------SCRQCTEC-FHADS-LRYSLRR ---------------------------------------------IHTYRALAS------------------ ------------------------------------------------------------------------ PAWISLTTE----------------------------------------------------------DPI-- ------------------------------------------------------------------------ ---LAAFKLSWELERLAR------------------------------------------------------ -----------------------VENEFKDTYL--ELSEQCKKYTCELLHQCRSTQE--------------- VIAVLNRRSE-------------------------------------EDSD--------------------- NDDD-DDP-----------------------------------------QQLKLSRLKLALKYD-Q-----K QFVAHPNCQ-----------QLLTSV--------------------------------------WH------ ----------------EGLPIWRRRNAVVKILLCFS--IIICMPLIAI--IYLIFP---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------RTRLG--------RVIRSPFMKFIYHSASFGLFLVLLVLAS--------------TR TEGSER------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------HRR----------------------------------------------------- ------NVRGPAPTFVEWLIFFWVTGMVW---------AECK-QL--WEE---------------------- GLTAYI-R----------QWWNWLDFIM-------------------LSLYLCTFSLRAVAFVQITTNKYG- ---------PREVP-----------------RA-------------QWPANDPTLIAEGVF----AVANVFS FARIIYLFQ----------------------------------------------TNPHLGP--LQISLGCM II-DIAKFLFIFFLVLTSF--ACGLNQLYWYY-DSPAASCNSSS---------------------------- -GDYA------------------------------------C----HTGSD-A------------------- --------------------------------------------FNTGAGE---------------STGEY- -------------------------------------------------RGGFQTLDV--------T----- ---------------------FATLFWSLFGISS--PKSTD------------------------------- ---------------LEEE--------------------HVFI--ETVGQ----GLFMAYHVMSIIVLINML IAMMSNSFQQIEDHADQEWKFARSKLW------------------------MSYFDP--------------- --GSTLP-------AP--------------------FNLIISPKSVFYLMRNVKNCMQFI-----------C FRRG----------------RTRPDK---R-NFGMEKGALQ-SGQH------TPRPGKHSRYAEVMRRLVS- --------------------------RYIHQTKKQ------------------------------------- ------------HRQDGVNEDD-LLEIKQDISSLRYELREDR------------------------KRETAR AYGQMDS----------------------------IKKDILR---------LLKQSGRVGSR---------- ------------------------GRD------------AEG--GG----------------TAGPASG--- --NPV-------------------------------------------------------VVTTPAAPCPAC SQTQ---------------------------------GVEPGLSSGA-----------SGLGIIQQHSVDL- -------------------------------GMLGRDASASLG--------------AAVD----------- ---------------------------------------------------------------ITVTPASSL -------PCNL---------TYSQ------------------GNLTG--------------------CLLAP QEMDYLRKEIV-SS---------------------------LRNELRDMLRDA------------------- ------------------------------------------------------------------------ -----------LTRALTPTTTMSSH--TYYSPT--------------------------------------- ---------PTPNP--------TPQ-FV----------TPHMTTPQ------FSLPA--------------- ------------------------------------------------------------------------ -----------------------------------PP----------------------------------- --------------------------------------------------------------------SQSS A--------PS-------------GLPSP-----TSTTAA-SHFLVTDSSSVGESCG-AQRLCPSSSSQTVT RSTPSP------------------------------------------------------------------ --------------------------VPQGHS--PTQP--------------------------CPS----- ---------------P--PIEA-S----------------------------------------------GG V----------VHRTMQEAPLAAASKPPTSQ----------------------------------------- -------------------------------------------------------DIL-------------- ----------------------------------------------LRPPNES------------------- ----------------------------------------------------DRV----------------- --------------------------------------------------HTHM----YTQL---------- >Csap1301010_Pain1/1-926 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------MA---------------- ---------------------------------------------GY--LALRSME---------------- ------------------------------------------------------------------------ ---------------------------------------------------------------ENGKATQGG -------------------------------GGAAGE-----EEVHFKQE---------------------- --------------------------------LLVA-VQT-----------------GDE-E-------KLR HALKHL----------------------------------PPKA-VN------------------------- ------------------------------------------------H-------------VFPH------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------PVSA--------------------------------------------------------- TALHV---------------------ATQNNS-----YELVKALLE--------------------VP-AD- ---------TGARDMR--GKK--------------------------------------------------- -----------------------------------YCPL--HYAAHNGNVEVLEALLK-------------- --------------------------------------------AGA--DPNAKEG-----------EFGRT SLHILAN----------------------------------------------------------RW-K--- -NNEDS----YK-ACLDALLS-----------------------------CKR-----IKV----------- -----------------------------DA-L-----DSSKA-------SPLFLAAT-------------- ---------KGWEYMV--------RKLINM-GAN-INAAVGN--------------KTASDVIKKKFNDLL- -------------DTIDFSVIKKPKRYFSDELYDALINKDLQLFQEILNEIENSEEKSKV------------ -SALEEDHGEYTLL--------QYACD---------NGLEDFVE---------------------------- ------ELL---------KHGANAARVD-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --ETSLMSPV--------------------------LYAARN----G------------------------Y YKILE--------------------------------MLLRT----------SKE-------QKE------- ---LDKGV---------------------LRHKDLRKETVLHKVIKREY-ATKH--EGVDYYRC-LELLLEK RRY----------------------------------------LDLDAQDE-F------------------- --------------------------GNT------------------------------------------- --------------------------------------------------------------------ALHY AVL------------------CDDQ---------SFVRILLLNGAHLGI-RNQ------------------- -FGTLAITRIQ------------------------------------------------------------- -----------------------------------------ASVLEEVLNDCIKYK---------HNVADRE FEIILHYSM--------------------------------------------------------------- LAP----------------------------------AQTSQQ--------PETECLRFLSGSR-K----HR HLLLHPIID-----------TFLFLK--------------------------------------WQ------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------R------------------- ----------------IQKY-----------------YYFNIIAYTIFLILLTAYI-------------LIY HG------------------------------------------------TFVPT----------------- -T--E------------NGI-------N---DD-------------TQ------------------------ ------------------------------------------------------------------------ -KQ-NVSSENSSDTSEMEM----------------------------------------------------- -------YDLAQKYVFKALILIFALYIAV---------REGV-QF--YV----------------------- SWKMYV-I----------RLENWLEISI----------------------VVLTCTVLFIPMN--------- -------------------------------VV-------------HLQ---------SLC----AWLVLFS WIEFVLLLG----------------------------------------------RHPYLSI--YITMFTTV TF-NFLKFIIMFSFMIVAF--SISFYLVF------------------------------------------- QVHDS-------------------------------------------FTT-Y------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------YQS----- ---------------------LLKTIAMTTGEIE--YTDLPLA----------------------------- ----------------------------------------AF---PVSSH----LLFVVFVFLIVLVLMNLL NGLAVSDIQQIQQEAEIVSYSSRVELV------------------------SYIESVFLASPL--------- --HQILPGS--------LRCCEGGDEKDDCYLKACIESHNPAIKLL-----------NWLGR---------- --RTLMFQTC-----------------------------------------------LRN-PWISV------ --------------------------FPNRG-------------RDRWH----------------------- -------VC--DCHSFHLKEAQ-IEAAKD---------------------------------VVLEKEHAVD N----------------------------------------------------------------------- -------------------------------------HR--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------LSGLENRLD-----------------EV--------------------------- ------------------------------------------MAAISSLTDK-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------VNKHVL---------------------------------------------- --------------------------------------------------------------------LPSP E----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Csap1414987_Pkd2/1-793 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------M-------------------- -------------------------------------------------SN--------------------- ----------PASELER------------------------------------------------------- ------------------------------------------------------------------P----- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------GTNSSNRQAWGQD------------GRGGG GGAG-----------------------------------------------------------TAVVDTY-- ---EYDDNEEI------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------RKK---------------- ------------------------------------------------------------------------ ---------------------GCWYKFST------------------------------------------- -----------------------------------------FVS---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------RI--WATRQMTKREDREVYVR--TT-------LRE LL-----------------------------------------VYAIFLVDLCIIT-----------F-GMT SPTMFY------------------------------------------------------------------ --YTKVL------S--ELFL---------------------------------------------------- --------------------------------------------------DAPYPDTK-------------- ---------NSFRGST--------QV---------------------------------------------- ------------------------------------------------------------------------ ------------------------------------LDFWRFSE---------------------------- ------NVLL------DGLYWEHWY----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------DV---------------------------SATNTS----K------------------------D DRNI---------------------------------LYENR-L--LGVPRIRQL----------------- ------------------------------------------RV------HNTSCEIP---QDF-QRVIRQC ---------------------------------------------YSEYSP--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------ANEDKSEFS--PNGENTTAWKYFSEKQLNGSVH--------------- WGKIAHY----------------------------------------------------------------- ---------------------------------------SGAG---------SYVDLGA-NRTT-T-----K NILA----------------ELRDKL--------------------------------------WI------ ----------------Q-----RGTRAVFFDFTVYNA-NINLFCVIKL--VFEFPA---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------TGGII--------PSWEFRTVKLLRYVTPNDF--FVLACEC---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------IFVFFIL-YY-------IIEEAI-EI--KAL---------------------- KWS-YF-K----------STWNILDLLV-------------------IGISLLCIGFNVFCFFTISNKLQEL LEDP----------------------------D-------------IFADFEFLGYWQIQFNNAVAVCVFFA WFKLFKYIS----------------------------------------------FNKTMTQ--LSSTLSRC AM-DIAGFAIMFFIVFFAF--AQ-LGYLLF--------------------------G--------------- -------------------------------------------TQVRDFRK-F------------------- --------------------------------------------ID-------------------------- ------------------------------------------------------------------A----- ---------------------VFTLLRTILG-------DFN------------------------------- ---------------FHEI--------------------EEAN--RVLGP----IFFICYVFFVYFVLLNMF LAIINDTYSEVK----IEIANQRNEFE------------------------IADYFK--------------- -------------------------------------------RGYNN---------------------MMG KLGR----------------RDKI---------VDIQNALKLS---------DANGDGMLTFDEIRTNLKKC NFS----------------------DMEIEMFFAK------------------------------------- ------------YDTDGSRLLE-QDEVRRMLSDLEGQKVELET----------------A-KSEGDKQIKNE DRPSSGKASGESETRPASAS---------------SGHGSIT------SV-SFEEFSVLQRRVD-------- -------------------------RL------------EHS--IG---------------SIVSKIDA--- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------VLVK----------- ---------------------------------------------------------------LDHMEKNKH --------------------KRKE----------------TMGKLLD-------------------TITEND DMDDTTKRKHMEKM---------------------------VRDELDKWDGES------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------SPSM--------------------------------- ------------------------------------------------------------------------ ----------------------------------------------------------SHK----------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Csap1529864_TRPML/1-701 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------MNPGNH------ ------------------------------------------------------------------------ -----------------------------------------------------------------------A QCHIRRNSRDERSE---------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------GLSREQL-- ---------------------------------------------GHTD----------------------- --------------------------------TSQG---------------------GIE-N---------- --------------------------------------L-------EEA----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------PSHQELE-----------DMAQSLQNHSP--------------------------------- PEVKV---------------------VVPQGNC-----------------------------QRSRYG---- -------SVSSILPT-------DC-------GHLDDTSTTN-TTGIH------------------------- -----------------------------------CPNM---------TPSKMQRRLK-------------- ---FF--------------------------------------------FMNPMEKWH---------ARRRF PWKLLL------------------------------------------------------------------ -------------QIFKIVVV--------------------------------------------------- --------------------------------T-A---------------QLCLFAQQR------------- ---------YSHVNYLWDTKISFSHMFLKGWDTT-------------------------------------- ------------RE---------------------------------------------------------- -VQVYPPGSGPLAV-------------------YEKQDFFQYLD---------------------------- ------YAITTYSTINEKAIGTYSY----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ KYRDGELLLPTLCMAQYAGG----------------YVSPNN----N---------------TFMLN----D -TIAKSCIDIP--VELNVT-----------SWSSEE-FLKKK-N--YIL----NF----------------- --------------------------------------DLLMNIE--------------------FTFHLHT IKLRV-------------------------------------NLPFDMPEC--------------------- ------------------------------------------------------------------------ -------------------------------------------------------------------YGLTG KVI-----------------FNNHD----------------------------------------------- HDGQMLVNLD-------------------------------------------------------------- -------------------------------------------VAAQVLE-CQGSIKLVS-----EAYTLKV WRTFINVTSI-------------------------------------------------------------- -------------------MISII-----------------------------------------SLIMCVR ALYRAQLLRKTTE-------LFFRQQYGKELSLEERMEFVNL----------------------WY------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------LLICINDIFIIL---G-----SCLKIGL--------------------------- ESK---------NYEGYLDTWNVCSLFL-------------------------------------------- -----------------------------------------------------------------GLGNLLV WFGCLRYLG----------------------------------------------FFTTYNV--LILTLKKC IP-NVLRYSICLLMVFSGY--CLCGWLVLGPYH--------------------------------------- --------------------------FK--------------------FRS-F------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------SST----- ---------------------MECLYSLINGDDM--FATFSSTSG-K------------------------- ---------------------------------------DPVV--WWFSR----IYLYSFISLFIYVILSLF IAIIMDAYETIKEHIPKRYLDIYIYIYVERERERDLCCFCCPQPLQECISHNYYENGF-------------- ------P---------------------------------------------LNELMKFV------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------EEC-TEEPSS------------------------------------------- ------------------------------------------------------------------------ -------------------------GV-----------------FQDED----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------DHT----------------------- ------------------------------------------------------------------------ ------------IHDVINS----------------------------------------------------- ------------------------------------------------------------------------ ------------ICCCGYE----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------MNQQSA EYE--------------------------------------------------------------------- ------------------------------------------------------------------------ ---------------P-------------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------------------LLT-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Csap1583775_TRPA5/1-870 MYVCVYVCICVCVCVCVFNF---------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------PFQ------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------TRKRPLVRGLT---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---FKSTISGHE---------------------------------------------------NSTFLN--- ------------------------------------------------------------------------ ----------------------------------------I----------------GME-DLPDG------ ------------------------------------------------------------------------ -------------------------------------------------------------------ADDV- ---CEGHID--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------QNV--------------------------------------------------------- TALFS---------------------AIKRQ-----DADEVEMLVCDAI-----------------PG-SL- ------------------ETT------------------------------------CRG------------ -----------------------------------LTPL--LMACHQRDLPILKLLLQ-------------- --------------------------------------------HRA--QVEGKGS-----------N-GST PLHAAIWEGW-------------------------------------------------------------- ------N------EGVAELLK-----------------------------HGA------LPDLRDI------ -----------------------------SI-S-----SSTST----GANSPLKAAVM-------------- ---------TGNVAAL--------QLIFEH-HPS-LSVMDNEEGSLLHLAAHSHQPLMVKYLLEE------- -----------------------------------------KIPEEILK----------------------- ----SCDQKGDTVM--------HAVLS-KKSRDKYEKSQIEILR---------------------------- ------MFL---------EAHVDVNSKN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---KAGETPL--------------------------FLATRS----R------------------------L SQCTE--------------------------------LLLSY-G--ADPF-AMTE-------SGQ------- --------------------------------------SVIHGAC------------IGGCADT-LSLLLER CHLA---------------------------------------HLVTLSDK-E------------------- --------------------------GVL------------------------------------------- --------------------------------------------------------------------PFHC AVG------------------SYSI---------DCCQILLMNGDHLTY-RDG------------------- -DGTSRCSLL-------------------------------------------------------------- -------------------------------LQ--HFPDTSSQLLNRLFSSRITLSDD--------PQYDRN FRVFFDYSD--------------------------------------------------------------- ILSQNKG-------------------------------------------DIQSCFLQDI-NSF------EN DLLQHPLVE-----------SFVHLK--------------------------------------WL------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------K------------------- ----------------IRFL-----------------FYITLMTFFVFIIIHTVYI-------------IAI T----------------------------------------------------------------------- -------------------------------------------ST------CHKIC---------------- ------------------------------------------------------------------------ ----MDFSK--------------------------------------------------------------- ------------LSAFRILHLVMYLLILW---------PEVI-TM--IA----------------------- NPKAYL-R----------HWETLTKFVS----------------------LIASAYVVIAH----------- ------QHTSMNLG-------HTNIPQSPQ----KSTEHVDPSTNFHLRR--------EIS----AISVFFG WVELMMMFG----------------------------------------------RLPILGS--NVLMFARI AK-SAIKFIVAFIGLLVGF--SVSFMVLF----------------------SE------------------- --IDD-------------------------------------------FKT-F------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------GRS----- ---------------------FVKTLMMMIGEVD--YSSLVNE----------------------------- ---------------------------------------NT----AIISY----LILVIFLFLVCILMANLL IGLAVDDITSLQRIGSIARRAKQASHI------------------------VTFEKAIAVAKRFRLL----- ------P------------------------------------RRLVV---------TLIKT---------- --NA-----------------------------------------------------IDK--KKHI------ --------------------------YVNKNRKR--FSFC-------------------------------- -------------ENNLVPSQI-IKKAV---------------------------------ADAKANHISSE DSSVF--------------------------------S---------------------------------- ------------------------EKTKQEKN---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------SN---------------------------------- ------------------------------------------------------------------LLLQ-- ----------------KLEDLEKIITT----------------NM--------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------INTLSIQES S----------------------------------------------------------------------- --------------------------------------------------------------------KDVE ---------------S-HEK---------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Csap170861_Pain2/1-968 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------ML----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------KQNS-------- -------------------------------------------SCVSTTTT--------------------- ------------------------------------------------------------------------ -TTTSNTSAST------------------------------------------------------------- ------------------------------------------------------------------------ --------------------------------------------------TTTT------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------TATTIT- PCRWAYRRLPLKGVT---------------------------MTVATDS----------------------- -----QKTPLVKIE----MQRQTLNAELVRRHLEAD-NEA-----------------GMQ-Q--------ML QSWSVA-------------------------------------------------E---------------- ---------------------------------------VL--------------------------RPKH- ---EGQADG--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ NSLHT---------------------AVRCG-----AEKCLKALLS--------------------HR-LS- ---------KEELEAP-DLEG--------------------------------------------------- -----------------------------------HTAL--LTAVTNARHTALAHLLT-------------- --------------------------------------------AGA--NVNARDD-----------K-HRA ALHLLVLKLS-------------------------------------------------------KDSA--- -PAEDLL------KVADLLLSP---------------------------THAS------KL----------- -----------------------------D--L-----EPHANFLDLTAATPLALATAK------------L QKEDKARWVANLLELC--------KKLVKA-GAS-LAEDVNGA--------------TVEQVLTQ-----KG WLTEKLLNE------------------------RRQPPLLRPTAAHVVDLVCMRRSASEVRDALQGKRQEDV REAVNSKLGSDSLL--------SYAVN---------IMNTSLVD---------------------------- ------ELL---------KYGANPWLLE-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---GTKELPL--------------------------HRAAVK----GHVDIFIMLVTKMKDNKKTIDLRDHT ASLVQ--------------------------------KLMEN-SHTKTTQ-SKD------------------ ------------------------------------------------------------HLAC-LRYLLQ- ECQ------------------------------------------LDLNQKDP------------------- --------------------------DLT------------------------------------------- --------------------------------------------------------------------PLHL AAK-----------------YNQQE----------AARELLRAGAFLGA---------------RHVEFGK- -ECGAVLDSV-------------------------------------------------------------- ----------------------------------------LPETLEHAMDDCITHY-SDNDNDKTENVVGEH YTLHLDYRF--------------------------------------------------------------- LLPPKQG-----------------------------------DASKDSKPVNEVKTLMDVCNSKTH-----R HLIKHPLVQ-----------TLLYAK--------------------------------------WK------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------K------------------- ----------------VQWL-----------------YLGNLLLYLFFVSMLTTFA-------------YFL M-------------------------------------------------NLRVT----------------- -EARLSV------LQQNVTI-------N---TT--------------------------------------- ------------------------------------------------------------------------ ------------SLEASRQ--------------------------GKQ----IIVH---------------- --------------VIRVLLLLAWLFMLV---------RMGL-QI--TL----------------------- SFK-YL-K----------KIENWLQW-S----------------------LLVLVPVLCFVPL--------- -------EMDAI-------------------------------------R--------QLS----AWSMIIA WFVFVLKLG----------------------------------------------RVPFFAL--YITMLRHV TS-NFLRLTILYSILILAF--TLSFNILLF---------------------HH------------------- --SGDS--------------------------------------QSGE--E-F------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------LS------ ---------------------FPRAVVMSTGELE--FSDMSEK----------------------------- ----------FPDTLR------------------------------TSAI----LMTLVFVFAIFLVLMNVM NALAVTDAQEVVNDTKLYSLISLLELV------------------------NTIET-FLGYSIVRSGL---- -------------------------------------------GNLQ------------------------- -----LLS----------------------------GSNNAPS--------------------FLA------ --------------------------KINLPNEHE------RLL--------SG------------------ -------------QDYNTPNKL-NDEAAQ-CLRV-HRL-------------------------HHLE-E--- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------KRNQ--------------------QRDQA---------- ---------------------------------------------------------------AAELEDA-- ------------------------VQ-----------------DL--------------------------- ---------------------------------------------AAHHPN--------------------- ------------------------------------------------------------------------ -----------LLRSLAAA----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------LRPG Q----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Csap1763764_NompC/1-235 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------ML--FFSLF------------------GLVE--------- ------PDY-MPPFY-------------------------SH---PVWSQTLMKIVFGIYQMVTVVVLINLL IAMMSDTYQRIQAKS-------------------------------------DTEWKF-------------- ------GL-----------------------------------AKLI----------RNMSR---------- --TS-----------------------------------------------------------GTP------ --------------------------SPLNL----------------------------------------- -----------------LVKFI-VYIIAI------FKFKCN---------------------LCSEK----- -------------------------------AMDYMRT-----------EGRTEDSHLADLK---------- --------------------------------TEFGGGWIKK--LRS------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------RSKAS----------------------------------- ------------------------------------------------------------------ITPQ-- -------------------------------------------ST--------------------ENLVP-- ---------------------------------------------LSNMEGP-------------QGVRRIE NVIK------------------------WSRV---------------------------------------- ---------VNRYRIMHRK----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------EVQP------------------------------------------------ --------------------------------------------------------------------GESS DGE--------------------------------------------------------------------- ---------------------------NDMPT--DS----------------------------------IE ---------------D-LHEEALL------------------------------------------------ -------------NGNIESNSSQPTNA--------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Csap1796860_Nan2/1-320 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------DEVVTQPPED-A-----VTVQYLV--EGE---TTPVT-------------- ---------LGSGLND--------LLNSTA-TSD-------------------------------------- ------------PL---------------------------------------------------------- ----STSQ--RPPL---------VFTC---------HNK--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------THHLHL----T------------------------A VNTSF--------------------------------FITKI---------IRRA-------KYSKT----- --------------------------------------PKAMLAV--------------------------- -------------------------------------------NPYDDSNSTND------------------ ------------------------TTSEN------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -PCYCAL----------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------WR------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------S------------------- ------------------------------------------------------------------------ PN---P---------------------------------------------------------------APG -ELQL------------------------------------------------------------------- ------------------------------------------------FGYY-------------------- ------LSEL-------------------------------------------------------------- ---------------QLYVRFGCEAVTLL---------GSLS-YL--VGA--------ANE-------ARFQ GGKMFI-E----------NLSTVPSRVL----------------------FLLACIMVLIMAALRAL----- -----------------------------CMNE--------------GED--------VLA----VLVMLCT GPYFLFFCR----------------------------------------------GFKTVGP-FVTMIYTML VG-DLLRFVTIYFVFIMGF--SQAYFIIF----------------------NSF------------------ HDT---------------FDRNQC--------------------LTSPMPS-A------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------AES----- ---------------------VMKMFIMSLGNFGDTYGALDCT----------------------------- ----------------------------------------DH---PTTGK---------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Csap180932_TRPA1/1-988 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------MRG-----------------NDP-A--------AR DLIACPE--V--------------------------------MLEAKDKQL--------------------- --------------------------------------------MTPLFVAATFGNFTICKALIDA-GASF- ---FCKDE---------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------SE----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------Q----------------------------------------------------------- MALHR---------------------ASMEG-----HLDIVELLLS--------------------SA-TKL GGAGMVRKLVEDQDD---EGQTCL---------HHAVNNGHYEIAQ-------------------------- -----------RLIQAGADVNTVRDSL--------TTPL--HAAAAIGHTDLIELLLK-------------- ------NRAR-----LDCIDSYQ-----------------------------------------------QT PLHKAAIYDQ-------------------------------------------------------------- ------P------AAITTLLA-----------------------------AGA------RI----------- -----------------------------ER-R-----DKDSF-------TPLLLAAS-------------- ---------GGHANAL--------QTLLDN-NAD-IEAVDKDDKTAVFWCAEQGNVEALEVLLN-------- ----------------------------------------DPRCADLVD----------------------- ----ESDRYDNSPL--------HEAAR---------RGYYNIID---------------------------- ------KLL---------AAGSRIDNKNEDEETA-------------------------------------- ------------------------------------------------------------------------ --------------------------------LHVAAEAGQVKVVRELLKH-------------YR--YLAK DENENSDTPL--------------------------HLACLQ----G------------------------H TDVVR--------------------------------VLLEA-G--ADVD-ARNS-------SLW------- --------------------------------------TPLDCAS------------AKGHVLC-VNELLDY DSP------------------------------------------LDPIDK-T------------------- --------------------------KTT------------------------------------------- --------------------------------------------------------------------PLQL AAK------------------EGHV---------AVTRLLLERGASLQA-CDT------------------- -SGRNALELA---IAAG---------------------------------------KKDVCMTIVKSSAWET AL-----KNVRTDYKGRRV------TPFRMLIR--KF----PDVAEAVLNRCTKSNGM--------DSDDER YAMRFKFDL------------VDDSYM-MSNYGSDT-DSINSISSMETP----------YDEDGRVLEDAKL YTSDFRD----------------------------------------IKKNHPLML---MVKYK-R-----L NLLNHPVSI-----------SLVKHK--------------------------------------WM------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------S------------------- ---------------YGRFV-----------------YYSTLVFYSVFLTFLTGYV-------------LTA K-------------------------------------------------DWLW------------------ ------------V--EQQLG-------N---VS--------------------------------------- -----------------------------------------------------NGRIL-------------- AQE-AMASGSCEDIKDK-VDLTNHG----------------------------------------------- -----------FVVAGKWVIIVMAAINIL---------REIF-QI--YQ----------------------- ARLNYIGL----------E--NLMEWCC----------------------YITAFLLVWDFTN--------- -----------------------------------------CPVREKWQW--------QVG----TASIFLA WMNLLLFIR----------------------------------------------KLPFLGI--YVVMFTDV FA-TFLRFCTVFVLFLIAF--GLCFFMVL----------------------RG------------------- --QLP-------------------------------------------FGS-L------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------PRS----- ---------------------LLKTTVMTIGEFE--YDSIF------------------------------- -------ND-VS-QTL------------------------PY---PEVTY----IVFVTFLALMSILIMNLL VGLAVDDIKAVQDQAILKRLAMQTQLV------------------------LDVEVFI-------------- ------P------------------------------------DALR----------RMYTT---------- --SK-----------------------------------------------------------KEV------ --------------------------HPNTR----------------------------------------- ------------------HGLL-SKKFGD------F------------------------------------ ------------------------------------------------------------------------ -------------------------------------QVLKS--FDV------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------VSDGE----------------------------------- ------------------------------------------------------------------MSEQ-- ---------------------ESMRQ-----------------EL--------------------TQLKAMV ------------------------------------------E-GLRSQNQR-------------------- ------------------------------------------------------------------------ ------------LHSLLVV----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------LTSM------------------------------------------------ --------------------------------------------------------------------TKGD DGA--------------------------------------------------------------------- ----------------------------KKET--DLAKLMW------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Csap1897696_TRPA1-like2/1-1150 ------------------------------------------------------------------------ --MKQSS----------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------IPLLV------ ----------------------------------------------QGSGGN----------RQQQQQQLQQ QQCK-VDID-----DDNNNLRRRPP----------------------------------------LML---- ERAISVRERWEEIG-VTANT---------------------------------------------------- --------------------------------HKYKNELLQKAAESEYE-ICEQL----------------- -------------------------LKSGQEEVN-----------TCDEETHETG----------------- --------LHIAAK---------NGHAALMQLFISYGA---------------------------------- ----DCNAKDSS---------------------------------------------------GKSPLHLAA ------------------------------------------TKDFFPC----------------------- -----CQALLVRPE----LEVNIANRTGDTP-LHHA-ARD-----------------GRA-R--------VC LTILNHPK-V--------------------------------IIDIQNKRG--------------------- --------------------------------------------MTPLHLAAQEDHRTVISLLLNK-GANW- ---KQQDK---------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------YSY--------------------------------------------------------- LPIHY---------------------AALKG-----FPESCEAILSF------------------------- ---------CNKNER---ESQLKA---------GL------------------------------------- ------------------------RDQ--------KTPL--MLAAKGGHHKCCVKL---------------- --------------------------------------------TNS--NINAQDR-----------E-GNT ALFYAAVGGF-------------------------------------------------------------- ------E------NTVAELLE-----------------------------CGA------DP----------- -----------------------------NI-S-----NKKGN-------SPILEAAG-------------- ---------KKRVNCL--------QRLLEK-NAS-VAIANKQGKTVLHQASWKNAQECLLILLDI------- -----------------------------------------PEAKKHLD----------------------- ----SKDTEDCTPL--------HTAIK---------REAVECAN---------------------------- ------YLL---------EHGASPTEVCKGRMTP-------------------------------------- ------------------------------------------------------------------------ --------------------------------LHLAADKGYTSVCEKLLAS---------PL------VHVS QENCKKATPL--------------------------HLAAMH----G------------------------S VDVCQ--------------------------------MLLRK-G--ARVT-AVDE-------NGR------- --------------------------------------SALHIAS------------IKGHDDV-IRFLAKK GVP------------------------------------------QRAKDD-T------------------- --------------------------GNT------------------------------------------- --------------------------------------------------------------------ALHL AAS------------------GGWL---------ESCQILVNSAKALVSDADH------------------- -NGNLPLDTA---FEKKHDNVFKFLLLQLPLKK---DDE-RALRLHQYMHSALKEKRLIAVDAIIDSAWWEA GFSG----------ENGHH-----CLNFQVLLE--ER----PHLALKAQNNCIQRKDS--------DTKVT- ----YDFRF------------FEFNYY-V-EGT-------GKVAKSPYDES-----------NGTVVKNAKQ FIVDGLE----------------------------------------WKRVHPVSL---MIKHH-H-----T FLLHHPLTK-----------AWLVDK--------------------------------------WN------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------L------------------- ---------------YISYI-----------------FLALLFIEFLFVVSLTLFM-------------AKV D-------------------------------------------------DWA------------------- --------------HIERRC-------N---MT------------------RDQFC---------------- ------------------------------------------------------------------------ -NPLFTAA-------EN-ANVTD---------------------AAG-----EVGRLGNC------------ -------AAVPRNIAGWLFLLSMTSIILL---------LEGN-YI--YR----------------------- LKREYL-------------------------SMDNS-MRIVE--------VILTVILLVPIGG--------- -------------------------------------CEVKYQVIHKEQW--------QCG----IIALLLA WLLLISKLN----------------------------------------------QLPVFSV--FVPITTNF IK-SFVKVLSYILLLLGLF--AFIFYLLL----------------------SE------------------- --QNA-------------------------------------------FST-M------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------PQA----- ---------------------MVKTIVWLLGDLG--YDDTFLNPDHE------------------------- ---------------L------------------------VY---PATAN----FLFVVFVTTISGFIVNLF VTQPSEKLEDFRKRTAFHTAASQSRLV------------------------LQLDLCF-------------- ------P--------------------------------------YF----------RKQRT---------- --RI-----------------------------------------------------------TV------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------TSTESEKSHS-KILAK- -----ILL-----------------KF---YSAEE----EEK--VAD------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------PILKK----------------------------------- ------------------------------------------------------------------LEEQ-- ---------------------HCQIS-----------------QL--------------------LSL---- ---------------------------------------------HMEQKEE-------------------- ------------------------------------------------------------------------ ------------IRDLKHQ----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------LNYI------------------------------------------------ --------------------------------------------------------------------MRNI SGQ--------------------------------------------------------------------- ---------------------------RPLE----------------------------------------- ---------------------RI------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Csap1910769_TRPM/1-1722 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------MAEPR-------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------WVETVFNKRE----------CIK--- ---------------------------------------------FIPSSK-DNA----------------- --RCCCGQLWQYHRDGS-PATLRHGE---------------------------------------------- --DLHWSPSRHT---------------------------------------------------QLLPTDAYG ILEFQGGAHP--------------------------------TKAHYIR----------------------- ------------------LAHDTRPDNTLQL-LTRE--------WGLDLPKLLITVQGGK-A-----NFDLQ PKLKK---------------------------------VIRKGLLKAAKTT--------------------- -----------------------------------GAWVFTAGTNTGV---------------TRHVGEAL- ---VTESSLRV------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------RSG---------------- ------------------------------------------------------------------------ ----------------------HLVSVGI------------------------------------------- ----------------------------------------APWG---------------------------- --------IIERRQDL-------------VG-----RN---------------------------------- KDVPY----HPMN--------------SPKSKFVALNKHHTFFLLVDNG-------------TVGKYG-PE- ---------LILRRKL--EN-------------YISKQRIETRGGL-------------------------- -----------------------------------ATPV--VCVVIEGGPQTIRQVLE--YVTDSP------ -----------------------------------------------PVPVIVCDG-----------T-GRA ADILAFVHKYTYSG-------LSMIEGSRETVIMTLGRVFELRPVQAEK-------------LYTEVLQ--- --CMRKR------DLISVFRLK----------------------------------EGSEL----------- -----------------------------DQ-S-I--------------LSALLHAQR-------------- ---------LNPPE----------QLSL-------------------------------------------- ------------------------------------------------------------------------ ------------AL------------------------TWNRVD---------------------------- ------IA------------RSHVFCEDVEWS---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------KGSL----------------------EQAMMDALVN----D------------------------R IEFVK--------------------------------LLLEQ-G--VIMNKFLTI--------QRL------ --------------------------------------EELYNS-------------KSGPSNT-LRYIIRD --------------------VKK-NIPRDYRYTLIDIGLVINKLMGGAYRAYYT-----------RKKFRTT YENTMLRSP------------RLHRNNSSI-----------------------------------------F QASKSLL-----------------------------------QKNPNTSPKSYISQDDFSFKFEFD-YPFSE LLVWAV--------------LTKRQ---------GMAMLMWQHGEEAIA----------------------- -KALVAAKLYKALAHEAADD---------------------------------------------------- ----------------------DLETEVYEELK--GYAKEFETLALQVMDYCYRQDDD-------------R AQQLLTYELK-------------------------------------------------------------- -------------------------------------------------NWSKQTCLSLAVADN-H-----R ALLSHTCCQ-----------ILLADL--------------------------------------WL------ ----------------GGLR--TRKNTNIKVM------LSLLIPPLVL--LLGFR----------------- -SREELKTMPQTREEHQYD-------------DPERSSDSESDTDSDDENMD-------------------- --LR-NDHDPEAQLVNSVSLPSHPVTPTLQPEAPLCNSNSAGPNPSTLVVPP-LPD-PSNLVDEL------H SSVRQNGVSG---------------------GQLSVLDTSAFLTI------------------------RSK QLSAR-----------IKFY--------EFYNAPITKFWAHSIAYVFFLCLFTYVV-------------LVK LDK--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------QPQWMEWYVIAYISTLIL---------EKVR-EI--LST----EPV-----------ELKQ KITVWS-D----------KLWNVCDLLF-------------------GVLFMIGMTLRLQ------------ -------------------------------------------------EQM-KDAGRVIY----CVDIIYW YLRILEILS----------------------------------------------ANKYLGP--LVMMMGKM IK-NMAYFVVLLLVVLMAF--GVCRQSILYPN-------------------EE------------------- -------------------------------------------PHWRLARH--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------I----- ---------------------FYQPYFMLYGEVF--AGDID---------------PECGG----------- -------K-DQIP-CHPGR---------------------------WLTP----TVMSMYLLVANILLINLL IAVFNNIFQEVNAISHQVWMFQRFQVV------------------------MEFEGK--------------- ---PVFP-------PP--------------------LIILSHIHRGIK----------YIFR---------- --RW----------------KGKP---------LLYDNGLKLFLDG------ESLERLHDFEEECMDGYNR- -------------------------EKDQKEQMST------------------------------------- ------------EERVRIMAER-TEGLAQRIEDMHAKFIGAMS----------------SVNNLDFHIKRLE ETMEQTKNSYAVVHRFMLSHVK----------HRRSASPCSG------SGSPKSDEGC-TSRSVSQTSL--- ------------------------HQM------------LEE--TEKL--------------MSRRHT---- -------------------------------------------------PEEE-------TSDKE------- ---------------------------------------GD------------------------------- ----------------------------------TTDAEHE-A-------------AR-VK-------LS-- ----PKSGHFEE-LLTSSNLGM------------LEGLSF---------ESMKA----------SSARQAKR ---------------QSR-RSKQRLD-----------SESGSSQGR------------------------AS RERRSS------------------------GG---------RKSSIRKSSNVSGDSKP-------------- ---------------------------------------------------MFSP-K--------------- ------VCF----MD--------------DT----------------------------------------- ---------------EEIPGHSSPP-KYERCL-S-NPN----------------QPIIQ------------- ------------------------------------------------------------------------ ----------------------------------VIPPSS-------------------PPQIFT------- -------------FASEYTSLADE---------------------------------------------LET VC--RLSPPSSP------------HLHFQSR---GPPPVRRRFLSESA--------GISITISS----NPLR DAEEADYQLMEGLIQRRMHRDSENLAVSLEDLCSVKTDFSDGEDGVY----------------------SHL GR---------RDSRATE--------LRKRHS---TSID--------------------------------- -----NNLPDMLSV-P-RSIPL-TSSRILSP-------TGRRSS---------------------FVCSNET -----------TRLAISQPNSPSTRRSSIHGD--------------------MRIHWASSSALPQPEAWQRA RPSP----------RPHSPPCV----------------------------LPQVLPMP-------------- ----------------------------------------------KAP-STTASVQSDSQPFM-------- ------------------------------------------------------------------------ -------ATLQVPA----------------------------VTEFESR-PKDSI---TETEC--------- >Csap1931409_TRPA5-2/1-791 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------MTPT-------- -------------------------------------------PGSRHA----------------------- -----------------PE------------------------------------------------L---- AND--SPPEDPAAKLL-------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------------------L-------------------------- ----------IPA----------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----T-----------------------------------MS-----TSESLS-A---------------- ------------------------------------------------------------------------ -------GS--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------RTV--------------------------------------------------------- --------------------------RVSTDTD--VD----------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------SDAPG--MCSWD--S-DSA RLLKMVDTEN-------------------------------------------------------------- ------L------EGLQALLA-----------------------------SGV------HV----------- -----------------------------NG-H------------------------G-------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------GTFHETAL--------HRAAQ---------IRWSAGVR---------------------------- ------YLL---------TAGASVYAKN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---QFGQTPL--------------------------HYAAAS----K------------------------S TTCIQ--------------------------------LLLE--N--RRPG-VVDH-------RD-------- ----MRGH------------------------------TPLHDAA------------SAGCVNA-LTLLLKA GAL------------------------------------------VRAKDG-T------------------- --------------------------GST------------------------------------------- --------------------------------------------------------------------PLHK AA------------------RARSV---------PCMVALLNAGADMSA-GDD------------------- -MGETVLAYT-------------------------------------------------------------- -------------------------------LH--YLP-G---FMDTVFDECLVTNSP--------KINTKT LEVTMNFLP--------------------------------------------------------------- LCCG--------------------------------------------SDKNQVQNLQSFVDMG-H-----A KLLSHPLCE-----------TFLLLK--------------------------------------WM------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------N------------------- ----------------VRRL-----------------FLIEVTLYLLFAVLTTVLT-------------FNK F-------------------------------------------------VWD------------------- -------------PNHDTDS-------N---RTCAEEDPL--------------NV---------------- ------------------------------------------------------------------------ ----EGPDQ---------------------------------LPSDAN----NALR---------------- -----------------GIVVTYLVVIML---------QQVL-SL--LQ----------------------- NKLQWF-R----------SLSGVLHVVI----------------------TVLVAGVVLPSK---------- -------------------------------------------VY-LWQQ--------HLA----SWLMLLL WTECMLLIG----------------------------------------------RFPNCGV--YVVMFTRV AK-VFLRIFLMYFCLLLAF--TAAFYVAL----------------------NY------------------- ---------------------QQG------------------CPKDRVLAN-P------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------LLT----- ---------------------FVKTLTMMIGELD--FGDDFVEGLSR------------------------- -----------------------------------------L---VFTGH----AIFLFFIILVSIILSNLL VALAVSDVQGLRNSAHLERLIKQTELV------------------------YHMEKNIS------------- -----------------------------------------TAAYIA----------SLVK----------- ------VSKLSA-----------------------MLMKVAMVCTY----DCYNTR-------VFY------ --------------------------LPNSPLKSN------KLFIVKNKKV--------------------- -------------KETNVPSYL-LANV--------NQC-------------------------LRGREADL- --------GG--------------------AGGDTGRS-------------MKARRGSRIRRGDYQKSEANN DEVKAGLK-----------------EL---------EANVIE--LVS------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------DKME--------------------EMRDT---------- ---------------------------------------------------------------YAELNKQ-- ------------------------ME-----------------AL--------------------------- ------------------------------------------QEKMKTIAS--------------------- ------------------------------------------------------------------------ -----------ALCKEEKKEG--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------EEEEEEEMRDTY----------------------------------------- -------------------------------------------------------------------AELNK QME--------------------------------------------------------------------- ---------------------------ALQEK---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Csap1948336_TRPApw/1-972 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---MPGGSAGD------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------MNEASAA----------------- ----------RHAA---------------------------------------------------------- ----------------------------------------------------------------VVAMQ-T- ------------------------------------------------------------------------ -----RQQLFRTVS----VD---------------E-SNP-----------------GT------------- ------------------------------------------------------------------------ --------------------------------------------------------------------PRL- ---RGPKPD--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------SRF--------------------------------------------------------- LAVVN---------------------AFKAR-----DVAEVRQLLR--------------------RG-LP- ---------VNHSE-P-AMGN--------------------------------------------------- -----------------------------------KTPL--ISAAEYGFLDGVVELLN-------------- --------------------------------------------AGG--NANAADA-----------A-GAT PLHM----------------------------------------------------------------A--- -AGGGYL------PTVRVLIS-----------------------------HGA------HV----------- -----------------------------NT-L-----DTHGS-------TPLHYA---------------- -----------------------------A-RAD-CQE---------------------------------- -----------------------------------------PNSSC-------------------------- -----------------------------------------LVE---------------------------- ------ALL---------AAGARCGLRD-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---REGQLPL--------------------------HKAAGA----G------------------------S ASVVR--------------------------------VLARE-PYKATVN-LKDN-------EGR------- --------------------------------------TPLHCAV-----------QGGRSLDV-VETLLQL ESI------------------------------------------INAKDK-Q------------------- --------------------------GHT------------------------------------------- --------------------------------------------------------------------PLHL AAKRQV-------------NYVDEDFD------GACLELLLAHGASVAA-TNNEGHNALSLALRRTMWWGRP GSRDHILDAVRQLVFKG------------------------------------------------------- ----------------------SCVQDGFAMWR--MVE-SFPSLVPMALNRSFSANTSARDSPH-------- --LRLDIDFN----------PLRVSAQ-----------------------------------QLLQTQRQSP LLP--QT-----------------------------------DLPKPLLQENEVSILHYIMKAGRK-----R LLL-HPLCH-----------SFLHLK--------------------------------------WY------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------K------------------- ----------------VRKY-----------------FLANVIFYLLFVLSLTAFL-------------LWS P-------------------------------------------------NCPKD----------------- -EAPGNG-------TDNAMA-------N---AT---AN---------------------------------- ------------------------------------------------------------------------ ------ATASAGSSCRLER--------------------------SEA----GLVG---------------- --------------LSWWCLVIFSGLLDL---------REII-QI--SQ----------------------- NPVLYI-L----------NVGNILDA-T----------------------LVFCVPLLLLLTS--------- -------DND-------------------------------CCLN-VDQQ--------QVG----AVTVVLA WVRFMLFTG----------------------------------------------QFPSCGV--YIVMFSTV AR-NVFKFLAMYVFILLAC--ALGFYVLL----------------------RP------------------- --FKT-------------------------------------------FEN-P------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------YIS----- ---------------------FVTSLVMMTGELD--YTDTFL------------------------------ -----------DSTYK------------------------------GLSI----VMLVGFMLFVYIILSNLL VGLAVSDMYAIQQRSELLRLTRHVELM------------------------VQVENLF------RSRL---- -----VP------------------------------------NALQ----------RL------------- -----LLRSITV-----------------------IDAEQRPTVSV----YPNSTHGLMD--SLFL------ --------------------------FLSRTLGGR------RLLIKIFEMFISGFIDP-------------- ------------EEEPSLPPQL-ITSVLDVALRE-HEL-------------------------DKRE-RLLH LRSLQ----------------------------------------------LGVASQ----RPGPSPSAP-N HVAAARAS-----------------SV-----------RPAA--LAG------------------RASWRWT ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------LISETD--------------------GDDDP---------- ---------------------------------------------------------------PDFLHPASA TQPPC-NPLWSAPSRAILPDPNVRLE-----------------EI--------------------------- ------------------------------------------KILLMQLQT--------------------- ------------------------------------------------------------------------ -----------RMDEVSRQ----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------VQEQ ATH--------------------------------------------------------------------- ---------------------------SSHRN--L------------------------------------- ------------------DIPTAA------------------------------------------------ -------------QSLETVNEVIV------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Csap1981719_TRPA1_like1/1-1055 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------ML---- HRTIAAE----------------------------------------------------------------- ----------------------------------------------DHE-RCLRL----------------- -------------------------LEDG-ENVN-----------ALDEKDGSSP----------------- --------LHALAKKT---WV--DGCEEVAVRLLERGA---------------------------------- ----KVNTKDSA---------------------------------------------------EHTPLHI-- ------------------------------------------------------------------------ -----------------------------------A-ARD-----------------GRF-K--------LC KLLLDNRR-AT-------------------------------NLNLNSRRDS-------------------- ------------------------------------------DLMTPLHYAAQEGWDEVVELLLQE-GADP- ---APQNK---------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------TKW--------------------------------------------------------- LPLHH---------------------AAAKG-----YEKCCRLLAPS------------------------- ---------YSPLSN---L----------------------------------------------------- -------------------------DV--------PPPL--FLAARKGYYKCCKEL---------------- ---V---------------------------------------IDKD--SLEYCDH-----------N-GNT ALHVMARNGF-------------------------------------------------------------- ------M------LSLEFLLD-----------------------------SGA------SI----------- -----------------------------NA-R-----NNSGN-------TPLMEAVK-------------- ---------NNKLVTV--------RLLTER-GAS-LTEKNNENSTVLHLAVLRKAHKCLEYLLSC------- -----------------------------------------PSIESLFN----------------------- ----VRDCKNLSPL--------SCAAK---------KDDTS-FN---------------------------- ------MLI---------EANALST--CKHGESL-------------------------------------- ------------------------------------------------------------------------ --------------------------------LHFRLVYRRPDMLQKLLQH---------HD------VDVR FSDDNGVTPL--------------------------HLAAEE----G------------------------S KVACS--------------------------------LLLNH-G--ARIN-ALDN-------SGK------- --------------------------------------SSLYMGA------------AAGHVQV-VRFLVSK GAL------------------------------------------VRPKGY-T------------------- --------------------------KST------------------------------------------- --------------------------------------------------------------------PLHA AAG------------------AGSR---------ECCQILLDTNSSLGKEQNE------------------- -NKRYALDLA---IEGGHIDTVELLLENFKF-----LPKDLTKRLHEYIHQCITTKNRELLEKIIRSKWWHI GCGL----------NTTLK--EPPCRSFRDIIQ--VY----PDLACEIMTRCREG---------------T- ---VNNFRL------------LENTTY-LQNGGRL------------------------------------- -------------------------------------------------EEHPVGV---MMACE-N-----L NLLQHPLVE-----------AWLCYK--------------------------------------WC------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------S------------------- ---------------YARWL-----------------FLAMLLLRVFLVAALMRFL-------------LYT T-------------------------------------------------NWI------------------- --------------QIEKKY-------N---LT------------------ENDICGG-------------- ------------------------------------------------------------------------ ----LNGD-----------------------GGLVEDSVVACWSASG-----TF------------------ -----------TNFEVHVHLASAFFLQVL---------EEAI-CL--RK----------------------- TGMHHV-------------------------EVFLL--RLPS--------MVLSLVALLPTSV--------- -------------------------------------CELKHGIKSVYGW--------ECA----ILALIFV WLDLIHNIN----------------------------------------------KLPQFVM--YSAVNVKF FK-SYAKGLMYLGMVMFVF--SFAFHLLL----------------------NE------------------- --QAS-------------------------------------------FRS-V------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------PLS----- ---------------------MVQVVVWMIGDLN--YDDNFLNAD--------------------------- ---------------L------------------------DY---PLLSI----SLFLLLVCTVGAFFVTLL KTPSCNK-----KRLRYCKQTGRLCLL------------------------LKIDMCF-------------- ------P--------------------------------------WF----------RNVFS---------- --AY-----------------------------------------------------------EYD------ --------------------------ENEKI----------------------------------------- ------------------PNFF-VKVVEH------FQ-------------------------CGGRS----- -------------------------------VPQQQDS-----------A----DSGQATVRCSIEKLIEKL ADFLEKMA-----------------DY---FQMDDNDDDSDD--EGD------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------CRQKK----------------------------------- ------------------------------------------------------------------EEVV-- ---------------------KKALQ-----------------QH--------------------TQM---- ---------------------------------------------FEEVRER-------------------- ------------------------------------------------------------------------ ------------MDQMMQH----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------LEERN----------------------------------------------- --------------------------------------------------------------------AQRL EGL--------------------------------------------------------------------- ---------------------------SRPPT--RRNT---------------------------------D ---------------D-FTEPDML------------------------------------------------ -------------T---------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >DmIav/1-1123 -----------------------------------------------------------------------M KFL-LKKC---------------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------------------LRK------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------KAPEMK------ ------------------------------------------------------------------------ --------------------------------------------------------------P-GAIL---- DAVISQSSA--------------------------------------------------------------- ---------------------------------------------TACKCLLYKLA---------------- ------------------------DYKRGGDLIDA------------------------------------- --------INSGGL---------------------------------------------------------- ------IAVEQL------------------------------------------------------------ ------------------------------------------IREQFGVF---------------------- --------------------------------MYND---------------------GKG-Q-----VINRA EFLRWKYRD--------------------------------------HTEVTIPIE---------------- --------------------------------------------------------------------ASL- ---SIHDPL--------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------GK----------------- --------------------------------------------WED------------------------- -------------------------------------------------------------HK--------- ----------------------------------------ACWQ---------------------------- ---------MQYRGALG-------------------E----------------------------------- SLLHV-------------------------------------LIIC-------------------------- ------------------------------------------------------------------------ -----------------------------------DSKV--HTK-------LARVLLR-------------- ---VF---------------------------------------PNLALDVMEGEEYL-----------GAS ALHLSI------------------------------------------------------------------ --AYSN------NELVADLIE-----------------------------AGA------DIHQRAIGSFFLP RDQQRANP-------------------AKS--T-----DYEGLAY--MGEYPLAWAAC-------------- ---------CANESVY--------NLLVDC-GSD-------------------------------------- ------------PD---------------------------------------------------------- ----AQDSFGNMIL--------HMVVV---------CDKLDMFG---------------------------- ------YALR------HPKTPAKNGIVN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---QTGLTPL--------------------------TLACKL----G------------------------R AEVFR--------------------------------EMLEL---------SARE-------FWRY------ --------------------------------------SNITCSG--------------------------- -------------------------------------------YPLNALDTLLP------------------ -------------------------DGRT------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -NWNSALFII-------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ LNGTKPE----------------------------------------------------------H-----L DMLDGGIIQ-----------RLLEEK--------------------------------------WK------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------T------------------- ---------------FAQNQ-----------------FLKRLLILSTHLLCLSVSV-------------YLR PAHDG------------------------------------------------------------------- ---EA----------------------E---DEDSE------------------------------------ ------------------------------------------------------------------------ ------GSDAS---------------------------------------AAALLDIQSDEGDSGGGDYN-- -----------AQTV---ARYCAEFATLV---------GVLS-YV-IFQQ--------GDE-------IKNQ GLSAFL-K----------QLSHAPAKAI----------------------FLFSNLLILACIPFRLI----- -----------------------------GDTD--------------TEE--------AIL----IFAVPGS WFLLMFFAG----------------------------------------------AIRLTGP-FVTMIYSMI TG-DMFTFGIIYCIVLCGF--SQAFYFLY----------------------KGH------------------ PQVQS-----------------------------------------TMFNT-Y------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------TST----- ---------------------WMALFQTTLGDYN--YPDLNQT----------------------------- ----------------------------------------TY---PNLSK----TVFVIFMIFVPILLLNML IAMMGNTYVTVIEQSEKEWMKQWAKIV------------------------VTLERAVPQADAKGYLE---- --AYSIPLGPSDD------------------------SGFEVRGVMVI---------KSKSK---------- -TRA----------------KQRKGA----------VSNWKRV------------------GRVTLTALKKR GMTGEEMRRLMWG-RASIS-------SPVKVTKQKLKDP------YNLHT---------------------- ------------------DSDF-TNAMDM-LTFA-SN----------------------------------- --PASSNGVTLRS----------------V-------TAPPP------------------------------ ---------------------------------------APP--APDPFR-----------ELIMMSDQR-- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------PETHDPH-----------------Y--FAG---------- ---------------------------------------------------------------LQQLANK-- --------------AFDL--VEQTMKTQPQAPVAKKVDPLPVASV--------------------AKASPAA PATQATATAAAASD----LMAMPLPISNL-SNL------FQDPKDIVDPKKLEEF---------MAMLAEVE T---EESDS------------------GGPILGK-------------------------------------- ---------LSLAKRTHNALSKAE------IRRDQQ------------------------------------ GFEGHSH--GQFQP------------MSSVWAPPGLDVDTGFH---------FDEA---------------- ------------------------------------------------------------------------ ---------------VAE--EVLTIEQEA------------------------------------------- -------------------EVETEDGN--------------------------------------------- ---------------------------------GGQDSEDIPTAEE--------------------VHATMK Q-------------------------------FHLRKCQPAQ------------------------------ ---------------------------DEAAR--RAKSARV------------------RRRNKVSP-EQSD ---------------D-PD----------------------------------------------------- -------------ERSQRGRSAYTRRTQSPPDP--------------------------------------- ------------------------------------------------------------------------ ------------------------------LEPW----------------STRELQDINK------------ ------------------------------------------------------------------------ -----------------------------------------ILARK-------------------------- >DmNan/1-833 ------------------------------------------------------------------------ --MGNTESNV-------------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------------------TSG------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------VKKQA------- ------------------------------------------------------------------------ --------------------------------------------------------------GVST------ ------------------------------------------------------------------------ -------------------------------------------------QALYKFV---------------- ------------------------NLKGGGLLVDM------------------------------------- --------MKRACQTK-------------------------------------------------------- ----QFAEIDHA------------------------------------------------------------ ------------------------------------------IKTKVEPF---------------------- --------------------------------LYNK---------------------GAG-R-----YFPIS KLVLLRNRDR-------------------------------------PRTRQLPEI---------------- --------------------------------------------------------------------RAL- ---ENPD----------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------DD----------------- --------------------------------------------FNI-HDY-----------CPEVSEAEYI S--------------------------------NPTAY-----------------------RF--------- ----------------------------------------VCWD---------------------------- ---------LNMRGAVG-------------------E----------------------------------- TILHL-------------------------------------CLLN-------------------------- ------------------------------------------------------------------------ -----------------------------------ASSL--HAD-------LAKRLLK-------------- ---FY---------------------------------------PKLILDIYMSDEYY-----------GES VLHIAI------------------------------------------------------------------ --VNED------PAMVKYLLD-----------------------------ANA------DVQERCCGAFMSA EDTKFSRTDS---------PDHEYVALCPM--T-----NYDGYVY--WGEYPLSFAAC-------------- ---------LSQEECF--------RLVLAR-GAD-------------------------------------- ------------PD---------------------------------------------------------- ----FQDTNGNTVL--------HMLVI---------YEKIEMFD---------------------------- ------VGY---------EVGTNIHIKN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---IQNLTPL--------------------------TLAAKL----G------------------------R VEMFF--------------------------------HVMSI---------EREI-------YWQL------ --------------------------------------GSITCAA--------------------------- -------------------------------------------YPLLMIDTINE------------------ ------------------------ETGNI------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -NKDSVLNFV-------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ VFGDKLE----------------------------------------------------------H-----L ELLDG-VVI-----------DLLKTK--------------------------------------WD------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------T------------------- ---------------FCKSR-----------------FYKQFYMFALYFLISLFSF-------------ILR PG---P------------------------------------------------------------------ -DAKD---------EDEDGA-------N---STTAKSDLYRQNGSDSYHLHSKRATMTTEYK---------- -------------TFWLN------------------------------FTEYYD------------------ ------PSEV-------EV-------------------LPAWWESYAQ---CPLMN-------LESDLAK-- ------------------LRIMAELLNFV---------GAIL-YL--LVA--------LRE-------ARFL GLKMFI-E----------NLMTAPSRVM----------------------FLFSCALMMTIPWLRVS----- -----------------------------CLTE--------------IDD--------HVT----VVIMLTT APYFLFFCR----------------------------------------------GFKTVGP-FVVMIYRMV MG-DLLRFVSIYLVFVMGF--SQAFYIIF----------------------LTF------------------ DNPSS------------PED-QDA--------------------ESNPMPS-P------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------MES----- ---------------------IVAMFLMSLTNFGDYYGAMVST----------------------------- ----------------------------------------QH---EYEAK----ILFFLFMVIVSVLLVNML IAMMGNTYQK-IAEIRNEWQRQWARIV------------------------LVVERSVPPAERLKNFM---- --QYSQSMSDGRR-----------------------------ALVLRL---------NMT------------ -EEK----------------EEMKEV-----------QEMKRI------------------HQRFAKKRQME REARALR----------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------RQQ--------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------EYEKFF----------------------------------------------- ------------------------------------------------------------------GTAPKS ECS--------------------------------------------------------------------- ---------------------------DNNNF---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >DmNompC/1-1619 ------------------------------------------------------------------------ --MSQP------------------------------------------------------------------ ------------------------------------------------------------------------ -RGGRGGGRGGGVG--------------RKTPSS-----------LTG------------------------ ----------------------------PPDESATPSERATPASKADSDPKD--DSSSN------------- ---------GDKKDMDL----------------------------------------FPAPKP--------- ----------------------------------------------PSAGAS----------IRDTANK-VL GLAMKSEWT-----PIEAELKKLEKYVANVG-EDGNHIPLAGVHDMNTGMTPLMYATKDNK---TAIM---- DRMIELGADVGARNNDNYNVLHIAAMYS----REDVVKLLLTKRGVDPFSTGGSRSQTAVHLVSSRQTGTAT NILRALLAAAGKDIRLKAD-------------GRGKIPLLLAVESGNQS-MCREL--L-------------- -------------------------AAQTAEQLK-----------AT-TANGDTA----------------- --------LHLAAR---------RRDVDMVRILVDYGT---------------------------------- ----NVDTQNGE---------------------------------------------------GQTPLHIAA ---------------------------------AEGDEA--------------------------------- -----LLKYFYGVR----ASASIADNQDRTP-MHLA-AEN-----------------GHA-H--------VI EILADKFK-A--------------------------------SIFERTKDG--------------------- --------------------------------------------STLMHIASLNGHAECATMLFKK-GVYL- ---HMPNK---------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------DGA--------------------------------------------------------- RSIHT---------------------AAAYG-----HTGIINTLLQ--------------------KG-EK- ---------VDVTTN---DNYTAL---------HIAVESAKPAVVETLLGFGADVHVRGGKLRETPLHIAAR VKD--GDRCALMLLKSGASPNLTTDDC--------LTPV--HVAARHGNLATLMQLLE-----DEGDPLYKS N-------TGETPLHMACRACHP---DIVRHLIETVKEKHGPDKATT--YINSVNE-----------D-GAT ALHYTCQITK-------------------------------------------------------EEVK--- -IPESDK------QIVRMLLE-----------------------------NGA------DVTLQTKTALETA FHYCAVAGNNDVLMEMISHMNPTDIQKAMNR-Q-----SSVGW-------TPLLIACH-------------- ---------RGHMELV--------NNLLAN-HAR-VDVFDTEGRSALHLAAERGYLHVCDALLTN------- --------------------------------------------KAFIN----------------------- ----SKSRVGRTAL--------HLAAM---------NGFTHLVKFLIKDHNAVIDILTLRKQTPLHLAAASG QMEVCQLLL---------ELGANIDATDDLGQKPIHVAAQNNYSEVAKLFLQ---QHPSLVNATSKDGNTCA HIAAMQGSVKVIEELMKFDRSGVISARNKLTDATPLQLAAEGGHADVVKALVRAGASCTEENKAGFTAVHLA AQNGHGQVLDV-LK--STNSLRINSKKLGLTPLHVAAYYGQADTVRELLTSVPATVKSETPT---GQSLFGD LGTESGMTPL--------------------------HLAAFS----G------------------------N ENVVR--------------------------------LLLNSAG--VQVDAATIE-------NGY------- --------------------------------------NPLHLAC------------FGGHMSV-VGLLLSR SAE-----------------------------------------LLQSQDR-N------------------- --------------------------GRT------------------------------------------- --------------------------------------------------------------------GLHI AAM------------------HGHI---------QMVEILLGQGAEINA-TDR------------------- -NGWTPLHCA---AKAG---------------------------------------HLEVVKLLCEAGASPK SETNYGCAAIWFAASEGHN------EVLRYLMN--KE----HDTYGLMEDK--------------------- ---RFVYNL------------MVVS----KNHNNKPIQEFVLVSPAPVDTA-AKLSNIYIVLSTKEKERAKD LVAAGKQC-----------------EAMATELLALAAGSDSAGKILQATDKRNVEFLDVLIENE-Q-----K EVIAHTVVQ-----------RYLQEL--------------------------------------WH------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------G------------------- ---------------SLTWA-----------------SWKILLLLVAFIVCPPVWI-------------GFT F----------------------------------------------------------------------- --------------PMGHKF-------N---KV--------------------------------------- ------------------------------------------------------------------------ ----------------------------------------------------PIIKFM-------------- -----------SYLTSHIYLMIHLSIVGI---------TPIY-PV--LRL---------S------------ -------L----------VP-YWYEVGLLIWLSGLLLFELTNPSDKSGLGSIKVLVLLLGMAGVGVHVSAFL ----------FV-------------------------SKEYWPTLVYCRN--------QCF----ALAFLLA CVQILDFLS----------------------------------------------FHHLFGP--WAIIIGDL LK-DLARFLAVLAIFVFGF--SMHIVAL-------------------------------------------- --NQS-------------------------------------------FAN-FS------------------ ------------------PED--------------------LRSFE----------------KKNRN----- ---RGYFSD--------------------------------------------------------------- ----------------------VRMHPINSFELL--FFAVF------------------GQTT--------- ------TEQ-TQVDKIKNVA----------------TP--TQ---PYWVEYLFKIVFGIYMLVSVVVLINLL IAMMSDTYQRIQV----------------------------------------------------------- --------------------------------------------VLL----------NALLS---------- --NS-----------------------------------------------------------T-------- ------------------------------------------------------------------------ ---------------------L-F---------------IN-------------------SYFNHKY----- -------------------------------INFILH----------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------CVL-----------------II--------------------LYFS--- ---------------------------------------------IRSKFTY-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------E ---------------D-DLYFLDI------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >DmPain/1-913 ------------------------------------------------------------------------ --MDFNNCGF-------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------IDPQAQ------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------LAGALAKQ-----------------------------DIR QFVAALDS---------------------------------------------------------------- -------------------------------------------------------------------GALA- ---DLQDDR--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------H---------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ TSIYE---------------------KALSTPG---CRDFIEACID--------------------HG-SQ- ---------VNYINK--------------------------------------------------------- --------------------------------KLDKAAI--SYAADSRDPGNLAALLK-------------- ---YR---------------------------------------PGN--KVQVDRKYG-----------QLT PLNSLAKNLT----------------------------------------------------------D--- -ENAPDVY-----SCMQLLLD-----------------------------YGA------SP----------- -----------------------------NI-V-----DQGEF-------TPLHHVLR-------------- ----KSKVKAGKKELI--------QLFLDHPELD-IDSYRNGE---------------VRRLLQAQFPELK- -LPEERHTG---PE-ID-------IQTLQRTLRDGDETLFEQQFAEYLQNLKGGADNQLN------------ ----AHQEEYFGLL--------QESIK---------RGRQRAFD---------------------------- ------VIL---------STGMDINSRP-------------------------------------------- ------------------------------------------------------------------------ ------------GR---------------------------------------------------------- ---ANEANLV--------------------------ETAVIY----G------------------------N WQALE--------------------------------RLLKE----PNLRLTPDS----------------- --------------------------------------KLLNAVIGRLD-EPPY--DGSSHQRC-FELLINS DRV-----------------------------------------DINEADS--------------------- --------------------------GRL------------------------------------------- -------------------------------------------------------------------VPLFF AVK------------------YRNT---------SAMQKLLKNGAYIGS-KSA------------------- -FGTLPIKDMP------------------------------------------------------------- -----------------------------------------PEVLEEHFDSCITTNGE--------RPGDQN FEIIIDYKN--------------------------------------------------------------- LMRQERDS-----------GL--------------------------NQLQDEMAPIAFIAESK-E----MR HLLQHPLIS-----------SFLFLK--------------------------------------WH------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------R------------------- ----------------LSVI-----------------FYLNFLIYSLFTASIITYT-------------LLK F----------------------------------------------------------------------- --------------HESDQR-------A---LTA-------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------FFGLLSWLGISYLIL---------RECI-QW--IM----------------------- SPVRYF-W----------SITNIMEVAL----------------------ITLSIFTCMESSF--------- -------------------------------DK-------------ETQR--------VLA----VFTILLV SMEFCLLVG----------------------------------------------SLPVLSISTHMLMLREV SN-SFLKSFTLYSIFVLTF--SLCFYILFG---------------------KSVEE---------------- DQSKSATPCP-------PLGKKEG------------------KDEEQGFNT-FTK----------------- ------------------------------------------------------------------------ ----------------------------------------------------------------PIE----- --------------------AVIKTIVMLTGEFD--AGSIQFT----------------------------- ---------------------------------------------SIYTY----LIFLLFVIFMTIVLFNLL NGLAVSDTQVIKAQAELNGAICRTNVL------------------------SRYEQVLTGHGRAGFLLG--- -------------------------------------------NHLFR---------SICQR---------- -----LMNIYP------------------------------------------NYLSLRQ---ISV------ --------------------------LPNDGNKVLIPMSD-----------------P-------------- -----------------FEMRT-LKKASF------QQLPLS--------------------AAVPQK----- ------------------------------------------------------------------------ -----KLL--------DPP-----LRL-----------------------------------LPCCCS---- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------LLTGKC---------------------------------- ----------------------------------------------------------------SQMSGRV- --------------------VKRALE-----------------VI--------------------------- -----------------------------------------DQKNAAEQRRKQ------------------E QINDS----------------------RLKLI---------------------------------------- ---------EYKLEQLIQL----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------VQDR K----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >DmPkd2/1-924 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------M-------------------- -------------------------------------------------AQ--------------------- ----------QGQSGRS-PSG--------------------------------------------------- ------------------------------------------------------------------PP---- ------------------------------------------------------------------------ ------------------GPPPPRP----------------------------------------------- ---------------------------------------PKTPPGASPRGTPTADSTP-------GDVTPAR GPPPPPATKRVSIGVGSTRSAPPPATDPTGPPPTAGKPVRDTGPSTSPR-PSLRDPGQSTSDKPSTSDKP-- ---STSDKPST------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------SAR---------------- ------------------------------------------------------------------------ ---------------------TTVREPGP------------------------------------------- -----------------------------------------SSS---------------------------- --------PSR-----------------PVS---TRES---------------------------------- GRITF----QE---------------AAPSTSAKVVKLAA-----------------------------SE- ---------PRPAKPP--EKEG----------FSLFKRKKKSVGSSTPP----------------------- ----------------------------SPSRGHRAPSI--IAASALQNRAKTNRILY--TTDEEVREALVE FS-----------------------------------------VFIIFLILTSLVV-----------L-SVR HTYMFY------------------------------------------------------------------ --FNDTM------K--KLFT-N------------------------------------REM----------- -----------------------------VV-A---------------------PSVT-------------- ---------VGFEKLI--------TV---------------------------------------------- ------------------------------------------------------------------------ ------------------------------------PDWWDYLK---------------------------- ------YNFL------VTLHGDLTFMDDAQAN-LTSM----------------------------------- ------------------------------------------------------------------------ --------------------------------PPEGSEQGSEQGSEQGSEQSPEEVVGEAPEEAPEMDRLQE DFKYN-GNPYIDLRGHRRAKRQSGVDGNSEDGSEDVSGNYLK----D------------------------D SDSIQANMSFHHL-------------------EGRVFLYENL-L--LGPPRLRQI----------------- ------------------------------------------RV------RKESCYVN---DAF-IRYFNTC ---------------------------------------------YAAYSS--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------GAEDRKPMH--KGS------PFRTMHDLDSTPI--------------- WTVLAFY----------------------------------------------------------------- ---------------------------------------RTGG---------YTVNLDY-DKDR-N-----V KIIN----------------DLKDIH--------------------------------------WL------ ----------------D-----RGSRLCLVEFNLFNE-NTDIFQSIKL--IAEIPP---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------TGGVI--------PQAHLQTVKMYSFFTDRS---MLMTVIY---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------IFWYIMVIYH-------TIYEIT-EI--RKS---------------------- GIKIYF-C----------SMLNILDCAI-------------------LLGCYLALVYNIWHSFKVMSLTARA HSD-----------------------------V-------------TYQSLDVLCFWNIIYVDMMAILAFLV WIKIFKFIS----------------------------------------------FNKTLVQ--FTTTLKRC SK-DLAGFSLMFGIVFLAY--AQ-LGLLLF--------------------------G--------------- -------------------------------------------TKHPDFRN-F------------------- --------------------------------------------IT-------------------------- ------------------------------------------------------------------S----- ---------------------ILTMIRMILG-------DFQ------------------------------- ---------------YNLI--------------------EQAN--RVLGP----IYFLTYILLVFFILLNMF LAIIMETYNTVK----GEITQGRSHLG------------------------SYIYRK--------------- ------------------------------------------LSGMLY---------------------WIT HCGR----------------KRRH---------HPQASETEDK---------DAEHDVGAAHDET------- ------------------------------------------------------------------------ ------------------------HEIRKNMTPAEQQYF---------------------------KDIPQG EN---------------------------------------------------QDMVRLNNRVG-------- -------------------------LL------------EEI--LE---------------KLINNMDD--- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------I-------------- ---------------------------------------------------------------LKRVEKDYH --------------------NKKK------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >DmPyr/1-956 ------------------------------------------------------------------------ --ME-------------------------------------------------------------------- ------------------------------------------------------------------------ --NVR----FSII----------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------ENDL-------- -------------------------------------------KWNSES----------------------- DPTADVDLL------LDKR----------------------------------------------------- --SIS--SEANSAGVF-------------------------------------------------------- ---------------------------------------------SDEAHEI-------------------- --------------------------------------------------FARQ------------------ ----------QQNQ---------------------------------------------------------- ------------------------------------------------------------------------ -ILWDLDEV----------------------------------KETL------------------------- ---------------------TESP--------------------------------GGK-H--------VV DMVQS---------GCF---------------------L----------ELMTD-S-ADCNL---------- ----------------------------------------------ALICCSVFGSVENTLFLLKHYNADP- ---NVAD-S--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------RGR--------------------------------------------------------- TPLHF---------------------ACCRA-----NAPIAKVLLD--------------------FG-AD- ---------PNRWDA---RKE--------------------------------------------------- -----------------------------------VTSL--HCAASSKSVECILLLLR-------------- --------------------------------------------RKA--SINIGIE-------------KRS ALHYAIDVNA-------------------------------------------------------------- ------V------DCVEILLK-----------------------------YGA------DP----------- -----------------------------NT-P-----QVYTE-------TPLHTASA-------------- ---------AGFAKCV--------QLLLSH-NAD-VRSQF-------------------------------- ------------------------------------------------------------------------ ------GEGKVTAL--------HLAAE---------NDYVECAR---------------------------- ------LLL---------EHRAEVDCRN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---ASHQTPL--------------------------HLACLS----Q------------------------S IGTVD--------------------------------LLISY-G--ANVN-AVYR-------DGR------- --------------------------------------TALHAAIVK----------QSRSLDC-CNALLKA GAD------------------------------------------VNKADN-Y------------------- --------------------------GYT------------------------------------------- --------------------------------------------------------------------PLHI AA------------------LNEFS---------SCVYTFIEHGADITA-RTD------------------- -GRVSALSFI-------------------------------------------------------------- -------------------------------VR--RTP-EIIPKLMQKLDSSIKANDQ--------EIGDVD CQIKLDFRL--------------------------------------------------------------- LVPSS------------------------------------------SMDRGETELLLSLIEVG-Q-----K RILMHPLCE-----------TFLFLK--------------------------------------WR------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------R------------------- ----------------IRKF-----------------FLMSLAYHTLFVILFTFYV-------------IWV Y-------------------------------------------------VRCCK----------------- -K--------------------------------------------------EEL----------------- ------------------------------------------------------------------------ --------------CVAPG----------------------------------YVS---------------- --------------TIGYLVIILNLILLG---------KEVF-QM--AH----------------------- GLRGYA-K----------YWENWLQW-T----------------------IGTGVLLCV------------- ------------TP-----------------ET-VRTDDLTA-VP-VWQH--------HVA----AIVILLV WLELMMLVG----------------------------------------------RFPIFGV--YVQMFTKV AV-NFAKFLLAYICLLVAF--GLSFAVLF----------------------ND------------------- --YPA-------------------------------------------FEN-I------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------TWS----- ---------------------FLKSITMMSGELE--FEDIFYG----------------------------- -------D---YA-VK-------------------------F---PVTAH----IIFLSFVLLVTVILTNLM VGLAVSDIQGLQVSATLDRLVRQAELV------------------------SRLESLFFSRLLRSA------ ------P------------------------------------TNLI----------QLCKR---------- --SA-LLR----------------------------TSRDKLQ--------------------FTI------ --------------------------RPNDPRDNQ------------------------------------- -----------------LPEDI-KLNV--------YKL-------------------------VAER-RDRN QSLRRRQ------------------------FENNYNI----------------FSRSLQRQQ---QPLHTD FLKPEPATG---TTKKTPQNLFHMHEL----------LRPRS--ATNV-------------PQQFRQEAEGT ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------VQMK--------------------NQANV---------- ---------------------------------------------------------------LSAVLAE-- ------------------------VQ-----------------AI--------------------------- ------------------------------------------KTQLVDLVA--------------------- ------------------------------------------------------------------------ -----------KFERFSEN----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------A--------------------------------------------------- ----------------------------------------------------------------------TR KLN--------------------------------------------------------------------- ---------------------------YSTD----------------------------------------- ------------------ELCR-------------------------------------------------- ----------------LRQQGQSVASS--------------------------------------------- ----------------------------------------------------HIRRHR-------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >DmTRP/1-1275 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------MG--------------------- ----------SNTE-----SD--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------AEKAL------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------GSR---------------- ------------------------------------------------------------------------ ---------------------L-------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------D---------------------------------- YDLM------------------------MA---------------------------------------EE- ----------YILSDV--EK---------------------------------------------------- -------------------------------------NF--ILSCERGDLPGVKKILE--EYQG-------- ---------------------------------------------TDKFNINCTDP-----------M-NRS ALISAI------------------------------------------------------------------ --ENENF------DLMVILL-E------------------------------------HNI----------- -----------------------------EV-G-----------------DALLHAIS-------------- ---------EEYVEAV--------EELLQW------------------------------------------ ------------EE---------------------------------------------------------- ------------TN--------HKEGQPY---------SWEAVD---------------------------- ------R-------------SKSTFTVDI------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------TPL--------------------------ILAAHR----N------------------------N YEILK--------------------------------ILLDR-G--ATLPMPHDV----------------- ------------------------------------------KC------GCDECVTS-QTTDS-LRHSQSR ---------------------------------------------INAYRALSA------------------ ------------------------------------------------------------------------ SSLIALSSR----------------------------------------------------------DPV-- ------------------------------------------------------------------------ ---LTVFQLSWELKRLQA------------------------------------------------------ -----------------------MESEFRAEYT--EMRQMVQDFGTSLLDHARTSME--------------- LEVMLNF-----------------------------------------NHE--------------------- --PSH-DI-------------------------------WCLG------QRQTLERLKLAIRYK-Q-----K TFVAHPNVQ-----------QLLAAI--------------------------------------WY------ ----------------DGLPGFRRKQASQQLMDVVK--LGCSFPIYSL--KYILAP---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------DSEGA--------KFMRKPFVKFITHSCSYMFFLMLLGAAS--------------LR VVQITF--------------------------------------------EL--L----------------- ---------------------------A-------------------------------------------- ------------------------------------------------------------------------ ------FPWMLTMLEDWRK----------------------------------------------------- ------HERGSLPGPIELAIITYIMALIF---------EELK-SL--YSD---------------------- GLFEYI-M----------DLWNIVDYIS-------------------NMFYVTWILCRATAWVIVHRDLWFR GIDP-------YFP-----------------RE-------------HWHPFDPMLLSEGAF----AAGMVFS YLKLVHIFS----------------------------------------------INPHLGP--LQVSLGRM II-DIIKFFFIYTLVLFAF--GCGLNQLLWYYAELEKNKCYHLH-------P-------DVADFD------- DQEKA------------------------------------C-TIWRRFSN-L------------------- --------------------------------------------FE-------------------------- ------------------------------------------------------------------T----- ---------------------SQSLFWASFGLVD--LVSFD------------------------------- ---------------LAGI--------------------KSFT--RFWAL----LMFGSYSVINIIVLLNML IAMMSNSYQIISERADTEWKFARSQLW------------------------MSYFED--------------- --GGTIP-------PP--------------------FNLCPNMKMLR----------------------KTL GRKR-----------------------------PSRTKSFMRK----------SMERAQTLHDKVMKLLVR- --------------------------RYITAEQRR------------------------------------- ------------RDDYGITEDD-IIEVRQDISSLRFELLEIF------------------------TNNSWD VPDIEK-----------------------------KSQGV-----------ARTTKGKVMER---------- -------------------------RI------------LKD--FQ-----------------IGFVEN--- ------------------------------------------------------------L-KQEM------ ------------------------------------------------------------------SE---- ----------------------------------SESGRDIFS--------------SLAK----------- ---------------------------------------------------------------VIGRKKT-Q --------------------KGDK----------------DWNAI--------------------------A R-KNTFASDPI-GS---------------------------KRSSMQRHSQRS------------------- ------------------------------------------------------------------------ -----------LRRKIIEQANE-GL--QMNQTQ--------------------------------------- ---------LIEFN---------PN-LGDV------TRATRVAYVK------FMRKKMAAD----------- ------------------------------------------------------------------------ ----------EVSLADDE--GAPNGEGEK------KPLDA-----SGS-----------KKSITSGGTGGGA SMLAAAALRASVKNVDEKSGADGKPGTMGKPTDDKK------------PGDDKDKQQPPKD-------SKPS AG------GPKPGD------------QKP-----TPGAGAPKPQAAGTI---------SKPGESQKKDAPA- --P--------------------------------------------------------------------- --------------------------PTKPGD--TK-P---------------------------AA----- ---------------P-KPGES-AKPEAAAK-------KEESSKT--------------------EASKPAA T----------NGAAKSAAPSAPSDAKPDSKLKPGAAGAPE------------------------------- --------------------------------------------------ATKATNGA-------------- ----------------------------------------------SKPDEKKSGPEEPK--KAAGDSK--- PG-DDAKDK---DKKPGDD-KDKKPGDDKDKKPADNNDKKPADDKDKKPGDDKDKKPG----DDKDKKPSDD KDKKPADDKDKKPAAAPLKPAIKVG--------------QSSAAAGGERGKSTV----TGRMISGWL----- >DmTRPA1/1-1274 ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------M TSGDK------------------------------------------------------------------- ----------------------------------------E------------------------------- -------------------------------------------------------------TP--------- ------------------------------------------------------------------KREDF- ASALR----------FLMG---------------------------GCAREPEMTAMAP------------- ---------LNLPK-----------------------KW-----------------ARILR----------- ------MSSTPKI---------------------PIVDYLEAAESGNLD-DFKRL----------------- -------------------------FMADNSRIA-----------LK-DAKGRTA----------------- --------AHQAAA---------RNRVNILRYIRDQNG---------------------------------- ----DFNAKDNA---------------------------------------------------GNTPLHIAV ------------------------------------------ESDAYD------------------------ -----ALDYLLSIP----VDTGVLNEKKQAP-VHLA-TEL-----------------NKV-K--------SL RVMGQYRNVI--------------------------------DIQQGGEHG--------------------- --------------------------------------------RTALHLAAIYDHEECARILITE--FDA- ---CPRKP---------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------CN----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------NGY--------------------------------------------------------- YPIHE---------------------AAKNA-----SSKTMEVFFQASYPFHFPIRTCPSCMLQLRWG-EQR GC--TREEMISFYDS---EGNVPL---------HSAVHGGDIKAVE-------------------------- -----------LCLKSGAKISTQQHDL--------STPV--HLACAQGAIDIVKLMFE-------------- ------MQPMEKRLCLSCTDVQK-----------------------------------------------MT PLHCASMFDH-------------------------------------------------------------- ------P------DIVSYLVA-----------------------------EGA------DI----------- -----------------------------NA-L-----DKEHR-------SPLLLAAS-------------- ---------RSGWKTV--------HLLIRL-GAC-ISVKDAAARNVLHFVIMNGG--RLTDFAEQV------ ---------------------------------ANCQTQAQLKL--LLN----------------------- ----EKDSMGCSPL--------HYASR---------DGHIRSLE---------------------------- ------NLI---------RLGACINLKNNNNESP-------------------------------------- ------------------------------------------------------------------------ --------------------------------LHFAARYGRYNTVRQLLDS-------------EKGSFIIN ESDGAGMTPL--------------------------HISSQQ----G------------------------H TRVVQ--------------------------------LLLNR-G--ALL--HRDH-------TGR------- --------------------------------------NPLQLAA------------MSGYTET-IELLHSV HSH-----------------------------------------LLDQVDK-D------------------- --------------------------GNT------------------------------------------- --------------------------------------------------------------------ALHL ATM------------------ENKP---------HAISVLMSMGCKLVY--NV------------------- -LDMSAIDYA---IYYK---------------------------------------YPEAALAMVTHEERAN --------EVMALRSDKHP------CVTLALIA--SM----PKVFEAVQDKCITKANC--------KKDSKS FYIKYSFAF------------LQCPFM-FAKIDEKTGESITTASPIPLPALNIKYSFWPYQKTPEQIEAKRK EFNDPK------------------------------------------WRPAPLAVVNTMVTHG-R-----V ELLAHPLSQ-----------KYLQMK--------------------------------------WN------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------S------------------- ---------------YGKYF-----------------HLANLLIYSIFLVFVTIYS-------------SLM M----------------------------------------------NNI---------------------- ---------------ELKAG-------D-------------------------------------------- ------------------------------------------------------------------------ -NK-TMSQYCNMGWEQL-TMNLSQNP-----SVASQIRLDSCEERINRT--TAIL----------------- -----------F---CAVVIVVYILLNSM---------RELI-QI--YQ----------------------- QKLHYI-L----------ETVNLISWVL----------------------YISALVMVTPAFQP-------- -----------------------------------------DGGINTIHY--------SAA----SIAVFLS WFRLLLFLQ----------------------------------------------RFDQVGI--YVVMFLEI LQ-TLIKVLMVFSILIIAF--GLAFYILL----------------------SKI------------IDPQ-- PNHLS-------------------------------------------FSN-I------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------PMS----- ---------------------LLRTFSMMLGELD--FVGTYVNTYYR------------------------- -------DQ------L------------------------KV---PMTSF----LILSVFMILMPILLMNLL IGLAVGDIESVRRNAQLKRLAMQVVLH------------------------TELERKL-------------- ------P------------------------------------HVWL----------QRVDK---------- --ME-----------------------------------------------------------LIE------ --------------------------YPNETKCK-------------------------------------- ------------------LGFC-DFILRK------W-FSNP------------------------------- ----------------------------------------------------FTEDCKLSGKRSG----TRS ---IQYTF-----------------NF---YAASMDVISFDN--NDD------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------YINAE----------------------------------- ------------------------------------------------------------------LERQ-- ---------------------RRKLR-----------------DI--------------------SRM---- ---------------------------------------------LEQQHHL-------------------- ------------------------------------------------------------------------ ------------VRLIVQK----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------MEIK------------------------------------------------ --------------------------------------------------------------------TEAD DVD--------------------------------------------------------------------- ---------------------------EGISP--NELRSVVGL----------------------RS-AGGN ---------------R-WNSPRVR------------------------------------------------ -------------NKLRA--ALSFNKS--------------------------------------------- ----------------------------------------------------M------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >DmTRPL/1-1124 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------MGRKKKL-PTGVSSGV---------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------SHASSAP----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------KSV------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------GGC---------------- ------------------------------------------------------------------------ ---------------------CVPLGLP-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------QPLLLE--EK---------------------------------------------------- -------------------------------------KF--LLAVERGDMPNVRRILQ--KALR-------- ---------------------------------------------HQHININCMDP-----------L-GRR ALTLAI------------------------------------------------------------------ --DNENL------EMVELLV-V------------------------------------MGV----------- -----------------------------ET-K-----------------DALLHAIN-------------- ---------AEFVEAV--------ELLLEH------------------------------------------ ------------EE---------------------------------------------------------- ------------LI--------YKEGEPY---------SWQKVD---------------------------- ------I-------------NTAMFAPDI------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------TPL--------------------------MLAAHK----N------------------------N FEILR--------------------------------ILLDR-G--AAVPVPHDI----------------- ------------------------------------------RC------GCEECVRL-TAEDS-LRHSLSR ---------------------------------------------VNIYRALCS------------------ ------------------------------------------------------------------------ PSLICLTSN----------------------------------------------------------DPI-- ------------------------------------------------------------------------ ---ITAFQLSWELRNLAL------------------------------------------------------ -----------------------TEQECKSEYM--DLRRQCQKFAVDLLDQTRTSNE--------------- LAIILNY-----------------------------------------D----------------------- --PQM-SS-------------------------------YEPG------DRMSLTRLVQAISYK-Q-----K KFVAHSNIQ-----------QLLSSI--------------------------------------WY------ ----------------DGLPGFRRKSIVDKVICIAQ--VAVLFPLYCL--IYMCAP---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------NCRTG--------QLMRKPFMKFLIHASSYLFFLFILILVS--------------QR ADDDFV--------------------------------------------RI--F----------------- ---------------------------G-------------------------------------------- ------------------------------------------------------------------------ ------TTRMKKELAEQEL----------------------------------------------------- ------RQRGQTPSKLELIVVMYVIGFVW---------EEVQ-EI--FAV---------------------- GMKSYL-R----------NMWNFIDFLR-------------------NSLYVSVMCLRAFAYIQQATEIARD PQMA-------YIP-----------------RE-------------KWHDFDPQLIAEGLF----AAANVFS ALKLVHLFS----------------------------------------------INPHLGP--LQISLGRM VI-DIVKFFFIYTLVLFAF--ACGLNQLLWYFAALEKSKCYVLP--------------GGEADWG------- SHGDS------------------------------------C-MKWRRFGN-L------------------- --------------------------------------------FE-------------------------- ------------------------------------------------------------------S----- ---------------------SQSLFWASFGMVG--LDDFE------------------------------- ---------------LSGI--------------------KSYT--RFWGL----LMFGSYSVINVIVLLNLL IAMMSNSYAMIDEHSDTEWKFARTKLW------------------------MSYFED--------------- --SATLP-------PP--------------------FNVLPSVKWVI----------------------RI- -FRK----------------SSKTI---------DRQRSKKRK-----------EQEQFSEYDNIMRSLVW- --------------------------RYVAAMHRK------------------------------------- ------------FENNPVSEDD-INEVKSEINTMRYEMLEIF------------------------ENSGMD VSSANK-----------------------------KERQ------------PRPRRIKVWER---------- -------------------------RL------------MKG--FQ-----------------VAPVQNG-- --CELDAFGNVN----------------------------GQGEMQEIKVESI------------------- ----------------------------------------PS-----------------------KPA---- ----------------------------------KETAKERFQ--------------RVAR----------- ---------------------------------------------------------------TVLLQSTTH ----------------------------------------KWNVV-----------------------LRAA --KD--SQI---GR---------------------------C-TKNERKSLQN------------------- ------------------------------------------------------------------------ -----------LGRAIEEAKRLIML--NPGCPS--------------------------------------- ---------GRESP-------IRIE-FEDE------KTSTLLELLN------QISAE--------------- ------------------------------------------------------------------------ -----------------------ISDSEKP--KI-RPIW--------------------RPPLKTV------ ---PARA--------MAANNTRS------LTAPELKI----------------------------------S RKSS----PA-PT-------------PTP------TPGVSHTALSQFRN----------RELPL----CPS- -------------------------------------KL--------------------------------- --------------------------IANSAP--SA-P--------------------------TAP----- ---------------P-KKSAP-T------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------APTPT-------------- ----------------------------------------------YKPTTHAPFSVEGGNRENTRA----- ------------SDGV------RSDNSNFDIHVVDLDEKGGHLGRDNV-SDISSIAS--------------- ----------TSPQRPKH------------------------------RN---------------------- >DmTRPM/1-1131 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------MYFETNWVF---------------------- ------------------------------------------------------------HQP--------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------RS---------------------------------------------------------------- ----------------------------------------------WIETNFQKRE----------CIK--- ---------------------------------------------FIPCPK-DDT----------------- --KCCCGQAQITHQTIP-GIESGSP----------------------------------------------- --GDLWLPTKHT---------------------------------------------------RPQPTDAYG TIEFQGGAHP--------------------------------TKAQYVR----------------------- ------------------LSFDTRPELLVQL-FTKE--------WNLELPKLLITVQGGK-A-----NFDLQ AKLKK---------------------------------EIRKGLLKAAKTT--------------------- -----------------------------------GAWIFTGGTNTGV---------------TKQVGDAL- ---LLEGQQ--------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------RTG---------------- ------------------------------------------------------------------------ ----------------------RVVSIGI------------------------------------------- ----------------------------------------APWG---------------------------- --------IVERNHEL-------------LG-----HN---------------------------------- REVPC----HSIS--------------SPRSKLAVLNNRHAYFLLVDNG-------------TQAKYG-AE- ---------LILRRKL--EK-------------FISNLKLHPFTHS-------------------------- -----------------------------------STPV--VCLVIEGGTNTIRAVLE--YVTDSP------ -----------------------------------------------PVPVVVCDG-----------S-GRA ADLLAFVHKYASDG-----EEQPVLESMRDYLIGTIQKTFEVGLDQSEK-------------LYQELLQ--- --CTRNK------NLITVFRI----------------------------QEKPE-GEAQEL----------- -----------------------------DQ-T-I--------------LTALFKSQH-------------- ---------LSPPE----------QLSL-------------------------------------------- ------------------------------------------------------------------------ ------------AL------------------------TWNRVD---------------------------- ------IA------------RSEIFVYGQEWP---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------NGAL----------------------DEAMMQALEH----D------------------------R IDFVK--------------------------------LLLEN-G--VSMKKFLTI--------PRL------ --------------------------------------EELYNT-------------KHGPANT-LGYILRD --------------------VRP-HIPKGYIYTLHDIGLVINKLMGGAYRSYYT-----------RRKFRPI YAKVMNSYA------------NACRKSSTY--------------------QYQRYAGAN------------- --SLSLV-----------------------------------TGLLPFTSEMAL----------FE-FPFNE LLIWAV--------------LTKRQ---------QMALLMWTHGEEALA----------------------- -KSLVSCKLYKAMAHEAAED---------------------------------------------------- ----------------------DLDTEIYEELR--SYAKEFESKGNKLLDFSYRQDAE-------------K AQRLLTCELH-------------------------------------------------------------- -------------------------------------------------SWSNQSCLSLAVAAN-H-----R ALLAHPCSQ-----------VILADL--------------------------------------WM------ ----------------GGLR--TRKNTNFKVI------LGLAMPFYIR--QLDFK----------------- -SKEELQQMPQTEEEHL-----------------------------ENQNLD-------------------- -----NDDS-----------------------------DRSQPDAEALLADTYS-------VRD-------- TKVHENGKV-----------------------SLTDSDTAQFREFFNLS--------------EYNEVKQHQ PLRLK-----------KKFY--------EFYTAPITKFWADSIAYMFFLIMFSFTV-------------LVK MEQ--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------MPRWQEWYSIAYITTLGF---------EKVR-EI--ISS----EPV-----------AITH KFSVWA-W----------NMWNPCDGAA-------------------IILFVIGLAFRFR------------ -------------------------------------------------ENT-MDIGRVIY----CVDSIYW YLRILNILG----------------------------------------------VNKYLGP--LVTMMGKM VK-NMIYFVVLLAVVLMSF--GVSRQAILYPN-------------------KQ------------------- -------------------------------------------PTWSLIKE--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------V----- ---------------------TFQPYFMLYGEVF--AGDID---------------PPCGE----------- -------DPSQPG-CVTGH---------------------------WVTP----ITMSMYLLIANILLINLL IAVFNNIFNEVNSVSHQVWMFQRFTVV------------------------MEYQQK--------------- ---PVLP-------PP--------------------FIALCHFYSLLK----------YCVR---------- --KA----------------KG-------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------EPG----------------MSK-------FS-- ----FV------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------P-CESIV-------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------SDAL----------------- >DmTRPML/1-652 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------MQSYGPGAQ------ ------------------------------------------------------------------------ -----------------------------------------------------------------------T APAVKR----RTDS---------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------Y-------------EAAQQQQ-- ------------------------------------------------------------------------ --------------------------------QSPE---------------------SDE-E---------- --------------------------------------YVNTRILRRQVQL--------------------- ------------------------------------------------------------------------ --QSTPVAPVV------------------------------------------------------------- ------------------------------------------------------------------------ ----------------------------------------------------PMPI---------------- ------------------------------------------------------------------------ -------------------------------------------------------------SA--------- ----------------------------------------GS------------------------------ -----------------------------------GTAP--------------------------------- PSVDG---------------------REEQPE---------------------------------------- -------------------------------FPGSSAASYQ------------------------------- -------------------------------------------------EERMRRKLQ-------------- ---FF--------------------------------------------FMNPIEKWQ---------AKRKF PYKFVV------------------------------------------------------------------ -------------QIVKIFLV--------------------------------------------------- --------------------------------T-M---------------QLCLFAHSR------------- ---------YNHINYTGDNRFAFSHLFLRGWDSS-------------------------------------- ------------RE---------------------------------------------------------- -VESYPPAVGPFAL-------------------YLKSEFFDTVQ---------------------------- ------YAVNGYANVSR-SIGPYDY----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ PTPNNTMPPLKLCLQNYREG----------------TIFGFN----E---------------SYIFD----P -HIDEVCE----RLPPNVT-----------TIGVEN-YLRQR-D--VEV----NF----------------- --------------------------------------ASLVSAQ--------------------LTFKIKT VNFKA------------------------------------NGGPLSAPDC--------------------- ------------------------------------------------------------------------ -------------------------------------------------------------------FRFDI SIT-----------------FNNRD----------------------------------------------- HDGQMLLSLD-------------------------------------------------------------- -------------------------------------------AEATRLK-CHGATDFIS-----DANFDSM LRSVLNIFVL-------------------------------------------------------------- -------------------LTCAL-----------------------------------------SFALCTR ALWRAYLLRCTTV-------NFFRSQFGKELSFDGRLEFVNF----------------------WY------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------IMIIFNDVLLII---G-----SALKEQI--------------------------- EGRYLV-V----------DQWDTCSLFL-------------------------------------------- -----------------------------------------------------------------GIGNLLV WFGVLRYLG----------------------------------------------FFKTYNV--VILTLKKA AP-KILRFLIAALLIYAGF--VFCGWLILGPYH--------------------------------------- --------------------------MK--------------------FRS-L------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------ATT----- ---------------------SECLFALINGDDM--FATFATLSS-K------------------------- ---------------------------------------ATWL--WWFCQ----IYLYSFISLYIYVVLSLF IAVIMDAYDTIK---------------------------------------AYYKDGF-------------- ------P---------------------------------------------TTDLKAFV------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------GTRTAEDISS------------------------------------------- ------------------------------------------------------------------------ -------------------------GV-----------------FMTDL----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------DDFDQT-------------------- ------------------------------------------------------------------------ -----------SFLDVVKS----------------------------------------------------- ------------------------------------------------------------------------ ------------ICCCGRC----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------G-RHQE PAQ--------------------------------------------------------------------- ------------------------------------------------------------------------ ---------------P-------------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------------------NSGYTSLSSI------------- ---------------------------------------------------MK------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ >DmTRPgamma/1-1128 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------MME-------------------------EE---------------------------------- NTIR------------------------PH---------------------------------------QE- ---------IRQLTLE--EK---------------------------------------------------- -------------------------------------KF--LLAVERGDMAGTRRMLQ--KAQDT------- ---------------------------------------------E-YINVNCVDP-----------L-GRT ALLMAI------------------------------------------------------------------ --DNENL------EMVELLI-N------------------------------------YNV----------- -----------------------------DT-K-----------------DALLHSIS-------------- ---------EEFVEAV--------EVLLDH------------------------------------------ ------------EN---------------------------------------------------------- -----------VTF--------HSEGN-H---------SWESAS---------------------------- ------E-------------DTSTFTPDI------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------TPL--------------------------ILAAHR----D------------------------N YEIIK--------------------------------ILLDR-G--AVLPMPHDV----------------- ------------------------------------------RC------GCDECVQS-RQEDS-LRHSRSR ---------------------------------------------INAYRALAG------------------ ------------------------------------------------------------------------ PSLIALSSK----------------------------------------------------------DPI-- ------------------------------------------------------------------------ ---LTAFELSWELRRLSL------------------------------------------------------ -----------------------LEHEFKNEYQ--ELRKQCQDFATALLDHTRTSHE--------------- LEILLNH-----------------------------------------D----------------------- --PTG-PV-------------------------------YEHG------ERMHLNRLKLAIKLR-Q-----K KFVAHSNVQ-----------QLLASI--------------------------------------WY------ ----------------EGLPGFRRKNMALQAVDIIR--IGIMFPIFSL--AYILAP---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------YSSIG--------QTMRKPFIKFICHSASYFTFLFLLMLAS--------------QR IETFIG--------------------------------------------GW--F----------------- ---------------------------F-------------------------------------------- ------------------------------------------------------------------------ ----ADSSGMLN-TMEELP----------------------------------------------------- ------TKRGAKPTFIEWLILAWVSGLIW---------SEVK-QL--WDV---------------------- GLQEYL-N----------DMWNVIDFVT-------------------NSLYVATVALRVVSFFQVQKEMIYN SHAT-------DLP-----------------RE-------------RWDAWDPMLISEGLF----SAANIFS SLKLVYIFS----------------------------------------------VNPHLGP--LQVSLSRM VM-DIMKFFFLYVLVLFAF--GSGLNQLLWYYADLEKKRCPEVS-PMSALLNMN---------GT------- NDPNA------------------------------------C-IVWRRFSN-L------------------- --------------------------------------------FE-------------------------- ------------------------------------------------------------------T----- ---------------------TQTLFWAVFGLID--LDSFE------------------------------- ---------------LDGI--------------------KIFT--RFWGM----LMFGTYSVINIVVLLNLL IAMMNHSYQLISERADVEWKFARSKLW------------------------ISYFEE--------------- --GGTCP-------PP--------------------FNIIPTPKSIWY-------AIKWMRR-------VFC SGSS----------------AARR----------EHLKTIRRKA--------QQASDRDFKYQQIMRNLVR- --------------------------RYVTVEQRK------------------------------------- ------------AESQGVTEDD-VNEIKQDISAFRCELVEIL------------------------KNSGMD TNVTAG-----------------------------QGGG------------GGGKKNRQKER---------- -------------------------RL------------MKG--FN-----------------IAP-PGSTG SLAPVAEFS---------------------------------TSLDNYDNQ------HE-ILSSTLSTLFT- ----------------------------------------PNFMH------------------KRQQSQAGS G------------------------------GGGSESPTTPTAP----------QGTQGAA----------- ---------------------------------------------------------------MTASSQVTK YNKSALKPY------NKRIAGHKK----------------RWGTL-----------------------IEAA K-VGNVSKML--GR---------------------------SKSEDSVCNSSHTSTPVHGQM---------- --------------------------------------------------------R--------------- ------VTYAQNSPQQEYGYHGETS--STTIST--------------------------------------- ---------PTPTI---------------------------------------------------------- ------------------------------------------------------------------------ ------------------------SVVSNS------PAA-------HAGVGSHFF------HTTS-GLT--- ----AIA------------ALKRKRKKFSSSK---------------------------------------- -------------N------------ICP-----VTESVAAANAAEILN---------NKTLKR-VSSYPAA EAG--------------------------------------------------------------------- --------------------------VQHNPA--QL-----------------------------VK----- ---------------P-RRHEQ-TQSQHDSV----------------------------------------- -----------------------------------ETNSTF------------------------------- --------------------------------------------------TLSI------------------ -----------------------------------------------DPSNTS------------------- -----------------------VNSR--------------------------------------------- -----------EPLISTSC-----------------------------------------VSTTGAIG---- >DmWtrw/1-986 ------------------------------------------------------------------------ --ME-------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------NLGYKEGS------------------------------- ------------------------------------------------------------TKPR-------- -------------------------------------------RMTR------------------------- ------------------------------------------------------------------------ --SISVVTKTEV------------------------------------------------------------ -----------------------------------EQPLT----ENNANNRFKSIP---------------- ------------------------------------------------------------------------ -----------PN-------------------LMVRW----------------------------------- --RNNTD----AMIEAQYPTAGE---------------------------------FEYMEC-GPSPPAESA PSMY----------------------------------------DSFEE----------------------- ------PTSELSVQ----ICNDTLRISLIDQ-MKSA-A-------------------GRV-K--------LF EDIEQ------------------------------------SNVVAEGIRTHFE-S--ASKL---------- ------------------------------------------EKNLCYLWAAYLKRWDLIESLLEA-GADL- ---HFCD-Q--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------NGI--------------------------------------------------------- SALHL---------------------SAFSG-----CLATLGLLVA--------------------KG-LN- ---------VNL--Q---SKC--------------------------------------------------- -----------------------------------YTPL--HCAAFGNAAEAAKLLIN-------------- --------------------------------------------NGA--DISKDTSKP--NCE-------ES LLHCAVRSNA-------------------------------------------------------------- ------L------ECLQIFIA-----------------------------EGA------DV----------- -----------------------------NS-L-----KPNGT-------NAIHLAAD-------------- ---------LGNIQCL--------EALLNAPNAD-ANVRIC------------------------------- ------------------------------------------------------------------------ -----IREKESTAL--------HLAAD---------EGNVECVD---------------------------- ------LLL---------AKGADAKLKN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---HRGFTPL--------------------------HLAART----S------------------------S LDCVE--------------------------------SLLRN-GN-ADAN-AEDF-------DHR------- --------------------------------------TPLHAAVGK----------SENAYDI-METLIQW GAN------------------------------------------VNHKDI-Y------------------- --------------------------GFT------------------------------------------- --------------------------------------------------------------------ALHL AA------------------LDGLV---------QCVEMLIFHGADVTT-KSK------------------- -KGTSALNVI-------------------------------------------------------------- -------------------------------TR--KTP-ASVAMIRQKLDAAITLHHSQ-------DPVNRE VELELDFRQ--------------------------------------------------------------- LLQH--------------------------------------------CHPREISYLNTFVDEG-Q-----K EILEHPLCS-----------SFLYIK--------------------------------------WG------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------K------------------- ----------------IRKY-----------------YIGRLIFCFSFVLFLTLYV-------------LTA L-------------------------------------------------AHNCY----------------- -NG-----------SKNDNT-------T---IP---AQ---------------ELC---------------- ------------------------------------------------------------------------ ----QKQSILGDMLRNNPF----------------------------------VME---------------- --------------MQWWVLVAITIVEIF---------RKLY-GITGYS----------------------- SFRHYV-T----------QVENIMEW-F----------------------VITSVFVISY------------ ----------IYTN-----------------K-----------TY-TFQN--------HIG----AFAVLLG WTNLMLMIG----------------------------------------------QLPVFDV--YVAMYTRV QG-EFAKLFMAYSCMLIGF--TISFCVIF----------------------PS------------------- --SSS-------------------------------------------FAN-P------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------FMG----- ---------------------FITVLVMMIGEQD--LSLLINDPEGK------------------------- -------D----PPFL-------------------------L---EVSAQ----ITFVLFLLFVTIILMNLL VGIAVHDIQGLKKTAGLSKLVRQTKLI------------------------SYIESALFNGYL--------- ------P------------------------------------TWLR----------NLLHY---------- --TA-LVS----------------------------PQAYRVV--------------------LCV------ --------------------------KPLNPSEKR------------------------------------- -----------------LPREI-LMKA--------YEV-------------------------GKMR-K--- ----------------------------------HFGH-------------TISSKNSAENYLSYKNKYNNN NGA---TT-----------------GYV-LPDSDPDAGQFTT--LTT------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------KID--------------------DNADR---------- ---------------------------------------------------------------IEFLTQE-- ------------------------IQ-----------------EL--------------------------- ------------------------------------------KQALISQQQQA------------------- ------------------------------------------------------------------------ ---------SKVIDKLLIV----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------ISNQQK---------------------------------------------- -----------------------------------------------------------------------Q NLR--------------------------------------------------------------------- ---------------------------K-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Dpul_Iav/1-757 ------------------------------------------------------------------------ ----MGNCK--------------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------------------GKA------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------NDPFNK------ ------------------------------------------------------------------------ --------------------------------------------------------------QNSSAF---- DRVTSRTS---------------------------------------------------------------- ---------------------------------------------TDDDCLLYQLA---------------- ------------------------DYQKGGDLIRY------------------------------------- --------FTKEGP---------------------------------------------------------- ------RATEEL------------------------------------------------------------ ------------------------------------------LKEQIPLL---------------------- --------------------------------LYRK---------------------GEG-Q-----IVRRS DYLKWKYRN--------------------------------------KRHVGVPVN---------------- ------------------------------------------------------------------------ ------EDV--------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------PG----------------- --------------------------------------------WKD------------------------- -------------------------------------------------------------HL--------- ----------------------------------------ACWN---------------------------- ---------FDYRGSLG-------------------E----------------------------------- SLLHV-------------------------------------LIVC-------------------------- ------------------------------------------------------------------------ -----------------------------------NTSI--HCK-------LAKLLIV-------------- ---LF---------------------------------------PNLALDVVEGNEFR-----------GAS ALHLAI------------------------------------------------------------------ --AYDS------LEVIKLLVE-----------------------------AGA------VVQQRAVGTFFLP RDQQRARP-------------------SRT--T-----DYEGLAY--FGEYPISWAAC-------------- ---------CNNEAAY--------NLLIDR-GAD-------------------------------------- ------------PN---------------------------------------------------------- ----SQDSFGNMVL--------HMVVV---------CNKLEMYG---------------------------- ------YALR------HPHIQAKMGIVN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---NAGLTPL--------------------------TLSCHL----G------------------------R ATIFR--------------------------------EMLEL---------TAKE-------FWRY------ --------------------------------------SNITCSA--------------------------- -------------------------------------------YPLNALDTILP------------------ -------------------------DGRC------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -NMTSALMII-------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ LNGTKEE----------------------------------------------------------H-----L DMLDGGIIQ-----------RLLEEK--------------------------------------WK------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------T------------------- ---------------FAQRQ-----------------FLKRLGILFFHLLVLSIAV-------------YTR P----------------------------------------------------------------------- -------------------------------RRDRP------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------LIPDD-------YDALN-- -----------AMDI---TRFCFEIITCL---------SCVG-YV-VIQQ--------ISE-------LKNV GLRGFL-Y----------QLSNNPAKAI----------------------FLASNFLTLACIPCRFY----- -----------------------------GNRD--------------VEE--------AIL----IFALPSA WFFLMFFAG----------------------------------------------AIRLTGP-FVTMIYSMI TG-DMLTFAIIYSIMLLAF--SQAFFFLH----------------------RGH------------------ PD--K-----------------------------------------TLFSN-F------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------LST----- ---------------------WMGLFHWTLGDYN--YNSLQDT----------------------------- ----------------------------------------VY---PAVTT----TVFVIFMIMVPILLLNML IAMMGNTYALVIQQSEKEWVKQWAKIV------------------------IALERAVNQMNCKEYLV---- --TYSIKVSGGSDGSDGS------------------PPQEEVRGVMVI---------KSKNK---------- -TRA----------------RQRKGA----------LNNWKRV------------------GKRTIKELKRR GITGDQLRRQIW------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------EP------------KTPSTTS--------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------INA------------------------------------------------- -------------------------------------------------------------------RYNLN --------------------------------FIID------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------CMS K----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Dpul_Nan/1-718 ------------------------------------------------------------------------ --MGNASSNV-------------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------------------TSG------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------IKKQAE------ ------------------------------------------------------------------------ --------------------------------------------------------------GAAS------ ------------------------------------------------------------------------ -------------------------------------------------STCYKLV---------------- ------------------------DLKGGGLLIEL------------------------------------- --------MKKASKTK-------------------------------------------------------- ----DFTEVDKT------------------------------------------------------------ ------------------------------------------IVEMVEPC---------------------- --------------------------------LYNK---------------------GLG-K-----MVHIA HLVLLRNRGR-------------------------------------AKTKLLPCL---------------- --------------------------------------------------------------------KEV- ---EDP------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------YK----------------- --------------------------------------------FDI-EKY--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------RGGVG-------------------E----------------------------------- TVMHL-------------------------------------CMLS-------------------------- ------------------------------------------------------------------------ -----------------------------------ATSI--HAD-------LAKRLLK-------------- ---FY---------------------------------------PKLIVDIYLDEEYY-----------GEN VLHIAI------------------------------------------------------------------ --VNED------PAMVKYLLD-----------------------------NGV------NYQDRCCGNFMSP EDQKASRYDS---------LTSEVVLNDAV--T-----NYDGYVY--WGEYPLAFAAC-------------- ---------LGQEECY--------RLVLAK-GAD-------------------------------------- ------------PN---------------------------------------------------------- ----GQDTNGNTVL--------HMLVI---------YDKTAMFD---------------------------- ------MAH---------ELGSLLNIRN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---RLGLTPL--------------------------TLAAKL----A------------------------R RDMFF--------------------------------HILKI---------QKEV-------YWQL------ --------------------------------------GNVTCSA--------------------------- -------------------------------------------YALPQLDTIDG------------------ ------------------------ATGGI------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -DKDSVLNLV-------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ VFGDSEA----------------------------------------------------------H-----L ELMDD-VVI-----------DLLHAK--------------------------------------WN------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------T------------------- ---------------FIKFR-----------------FYRCFLLFALYFVISLICF-------------TVR PS---P-------------PVRL------------------------------------------------- -REEM-----------TTTQ-------S---YTTT--DM--------------------------------- -------------TW--------------------------------------------------------- ------PSSP-------------------------------------------------------------- ------------------FSMGGEIGVLI---------GVAL-YL--GAA--------ARE-------ARFL GRKMFF-E----------NLATAPSRVL----------------------FLISCMFVIAMVFLRWF----- -----------------------------CLRA--------------EED--------IVA----VLVMLST APYFLFFCR----------------------------------------------GFKKVGP-FVVMIYRMI MG-DLLRFVTIYVVFVMGF--SQAYYIVF----------------------LTH------------------ PNN------------------REH--------------------AENPMPT-P------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------VDS----- ---------------------VMMMFLMSLYNFGSTYEAFART----------------------------- ----------------------------------------EH---ETVAK----ILFVVYMAIVGILLINML IAMMGNTYTK-IAETRNEWQRQWARIV------------------------LVVERGVDPKSRLENMV---- --LYSQPMVDGRR-----------------------------AFMLRQ---------QQSVN---------- -TSR----------------PEVTRIS---------VTEITPI------------------YILYL------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------FPP---------------------------------------------------------- >Dpul_NompC/1-1655 ------------------------------------------------------------------------ --MPKS------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------RDQTP------ESGDSIQSTGD------------- ---------SSSLGNKV------------------------------------------------------- ------------------------------------------------AGKR----------MIDSAKKKIL WLASKNEWG-----GLEQAMKTLEQTVAANKNSPELLSPLADIQDEFTGYTPLMYAVKDNR---ISLM---- ERMMELGCDLTTVNKDNYNTFHLAVLYS----REDVIKNLLARKA-DITILAGPRLQNVLHLVASRTGGSGA SVAKLLLASGAKDFRLARD-------------QEGYLPLHVAVEIGNMH-VTKEL--L-------------- -------------------------NMNGDVQVK-----------ATFGPKMEIA----------------- --------FHAATR---------RRDIELLRILNDQGS---------------------------------- ----PVDATNAE---------------------------------------------------GQTALHIAA ---------------------------------ADGDEN--------------------------------- -----IVKYLHMLH----ANPNISDNEDRTP-VLLA-AER-----------------GRT-V--------VV EILTEKFR-A--------------------------------SCLERTKDG--------------------- --------------------------------------------STLLHVASLHGHPETALMLLKK-GVPL- ---HMPNK---------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------SGA--------------------------------------------------------- RSIHI---------------------AARKG-----HVGVIQTLLL--------------------KG-EQ- ---------VDATTN---DNYTAL---------HVAVQAGKANVVETLLGYGAQVHIRAGPLQETPLHIAAR VTEG-GEKCVQMLLKSGCDANINRADG--------VRPL--HVAASEGHFGVVRLLLA-----DGADPLLVN I-------NGETPLQVACGTSHPGTLSVVQLLLEHVQAGSGS--AAT--YVNTRNS-----------I-GET SLHAASNQPRI-----------------------------------------------------TTTAK--- -GKYPDR------DIAQSLLQ-----------------------------AGG------DVSLDTYQTKENP LHYCASQGNVPVLVALLASIRPTELQRVVNK-Q-----NLLGR-------SPLQVAAK-------------- ---------NGHLQCV--------LLLLQN-QAR-VDVFDNDGMSALHLASESGHGAICDALLAH------- --------------------------------------------NAFVN----------------------- ----SKSRVGLTPI--------HLAAL---------KGYTELVRSLVTVHGATIDALTLRKETALQLAAGAG QLDVCSLLV---------ELGAETSAADELGRKAIHLAAQQNHSEVVRLFLK---HQPALVLAANKDGNTCA HIAAMQGSVDVLQQLMKFDLSIVTASRNRTSESTPLHLAAEGGHADVVKMLLEAGALPQDENKAGFTAIQLA AKNGHNVVIDV-LRDASPDTLSYASRRTGLNSLHVAACYGQSEIVREMLAHVPAGVRSEAPTSLSGTGVLRE LDGEAGLTPL--------------------------HLAAYS----G------------------------D ENVVR--------------------------------LLLNSAG--VTVDQPSAQ-------NGF------- --------------------------------------TALHLAC------------RGGHGPV-AGLLLSR STG-----------------------------------------LLTTPDG-H------------------- --------------------------GRS------------------------------------------- --------------------------------------------------------------------PLHV AAA------------------HGHG---------RLVELLLGQGADINA-ADK------------------- -AGWTALHLA---ARAG---------------------------------------HLAMVQLLLDSGATPR SFNDNGRIPLWYAASEGHT------SVLTLLLK--RE----HDAYGLMEDR--------------------- ---KFVYNL------------MVCG----KNHNNLPLCEFILESPAPVDVA-AKLSHILATLSVKEKERSKD LLEAAKHC-----------------ESMATELLALASSLEGAARLLTAQDRRQMPLLDILVEQE-Q-----K EVISHPAVQ-----------RYLQEV--------------------------------------WL------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------G------------------- ---------------GLQWA-----------------PWKLLLLFLCCVVLPPVWL-------------CLC L----------------------------------------------------------------------- --------------PLGHRY-------D---KI--------------------------------------- ------------------------------------------------------------------------ ----------------------------------------------------PVIRFM-------------- -----------AYLTSHIYLMTLLILTST---------LPIC-PV--LRT---------S------------ -------L----------LP-CWYEWLLLIWLSGVLLAELATPRDRGGLGWLRIAILFISAIAILIHAVAF- ----------LL-------------------------KPEHWTVALFFRN--------QLL----AVVVLLC CMLLLDFLS----------------------------------------------FHYLFGP--WAIIIGNL MV-DACRFLIILAIFMFGF--TMHVAAL-------------------------------------------- --NQP-------------------------------------------F----------------------- -------------WAR-------------------------------------------------------- -DITPITAK---------------------------------------------TITGG-----LNS----- ---------------------GVVVTPLDTFQLL--FFALF------------------GLTQ--------- ------PAD-LRMET-------------------------AQ---PEWTLFFYKIVFGFYMLVTTVVLINML IAMMSDTYQRIQAQS-------------------------------------DVEWKF-------------- ------GL-----------------------------------AKLV----------RAMHR---------- --TA-----------------------------------------------------------ATP------ --------------------------SPLNL----------------------------------------- -----------------FTSWI-SYLWQL------SRKQVV--------------------HENADD----- -------------------------------HARLVRQ-----------CA--------PSA---------- --------------------------------SENNKGWMRK--FQH------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------KTK----------------------------------- ------------------------------------------------------------------VGHR-- ---------------------ESNAL-----------------GV--------------------VRPAP-- ---------------------------------------------LSSQMSII------------GDRNSLE HVTD------------------------WRVV---------------------------------------- ---------VKQY----------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------------IS ---------------N-NLSQCN------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Dpul_Pyx1/1-603 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------MKE------- --------------------------------------TPLHGAVVK----------CRQSTDV-VKLLISK GAN------------------------------------------VNAKDQ-F------------------- --------------------------GQT------------------------------------------- --------------------------------------------------------------------PLHI AA------------------FNENS---------KLAILLIHSGADLSI-KNR------------------- -AKISALASV-------------------------------------------------------------- -------------------------------VR--RVP-DALTAISRKLDSAVDVVDN--------EPADPD CQLKLDLRV--------------------------------------------------------------- LVPGGN-----------------------------------------QQNVGEMGFLTSLVAAE-Q-----R HILQHPVIG-----------AFLHLK--------------------------------------WM------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------K------------------- ----------------IRTT-----------------FVVSLIFQLLYVLALTSNI-------------YSI Y-------------------------------------------------VVKMN----------------- -KR-----------VNN--T-------Q---KS---E---------------PS------------------ ------------------------------------------------------------------------ -------NATMTQFADWPM----------------------------------ELD---------------- -------------TTLWYLTVLLGAATGV---------KEFF-QL--YC----------------------- NVHEYA-R----------DIENYFQL-I----------------------SILGMILILS------------ -----------PHP-----------------MH-TDEPD----KG-DWQH--------HVA----AIVIIVA WINLMLHVG----------------------------------------------RFPVFGL--YVQMFTTV AW-NIGKLLVAYMSLILGF--SLGFAVLF----------------------PL------------------- --ENR-------------------------------------------YND-M------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------PYA----- ---------------------LLTTIVMMTGEME--YAAMY------------------------------- ----------TEGKIK-------------------------Y---PGTTH----FVFLVFLLFVVIVLMNLL VGLAVSDIQGLQKSAGLDRLVRLTKQI------------------------ARMESFVFFPWPIHF------ ------SSL-------------------------------WSKVPRR----------EFIRR---------- --NV-LVV----------------------------SPKTRKN--------------------YNF------ --------------------------RPNDPRDRS------------------------------------- -----------------FPPEI-KESL--------LKI-------------------------IAVRIANKK KGAQQ------------------------------KTS---------------------------------- -------------------------HV----------PIIRT--ATI--------------PL--------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------DS--------------------NNGEL---------- ---------------------------------------------------------------FTEVMNR-- ------------------------VD-----------------EL--------------------------F H---------------------------------------NYMTQIVTINS--------------------- ------------------------------------------------------------------------ -----------TIEDQLAQ----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------L--TAKYNYPS----------------------------------------- --------------------------------------------------------------------TRSR QTR--------------------------------------------------------------------- ---------------------------HS-----C------------------------------------- ------------------DCSMIN------------------------------------------------ -------------EESFRVPGISSQA---------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Dpul_Pyx2/1-838 ------------------------------------------------------------------------ --MS-------------------------------------------------------------------- ------------------------------------------------------------------------ --SRRSVSRENVR----------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------QRSF-------- -------------------------------------------PSLSSISE---------------TESPSF DFTESFEVL------DEGE----------------------------------------------------- --TIS------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------PTVW--------------------------------------------------------- ------------------------------------------------------------------------ -CVWPQQML----------------------------------MVAID------------------------ ---------------------EKLF--------------------------------TKS-P--------LN VRLCK------------------------------------PRLNVSLGESDWK-E-IPPDC---------- -------------------------------------------YDIGVLFAALNGAVL-------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------CLNLLIR--------------------YK-AT- ---------VDVLDR---NKE--------------------------------------------------- -----------------------------------ATPL--FCAAASGRIELVEALL--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------SCATRLVE-----------------------------AGA------NV----------- -----------------------------NN-L-----QVLCE-------SPIHVSAF-------------- ---------QGDVDCL--------KLLLEN-KAD-------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------AKASTTEIDKP------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --EAVGRTPL--------------------------HLAALS----Q------------------------S VESVK--------------------------------VLLDY-G--ARHD-ICDG-------MKE------- --------------------------------------TPLHSAVVK----------CRRSIDV-VRLLISR GAN------------------------------------------VNVKNQ-F------------------- --------------------------SQT------------------------------------------- --------------------------------------------------------------------PLHL AA------------------INEHS---------KLASFLILSGADLSA-KNR------------------- -AKNTALALV-------------------------------------------------------------- -------------------------------AR--RVP-DALSTISRKLDSAIEIAGGL-------DPTDAD CELRLDLQV--------------------------------------------------------------- LVPSGN-----------------------------------------QQKEGEMAMLTSMIAAD-Q-----H HLLLHPVIG-----------AFLHLK--------------------------------------WT------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------K------------------- ----------------IRTT-----------------FLASLMFQFCYVLFLTLNI-------------YTT Y-------------------------------------------------VSSKN----------------- -EK-----------AENGTT-------N---LT---N---------------HN------------------ ------------------------------------------------------------------------ -------NSTGTIVHNSALIDS---------------------QTQKS----YSLD---------------- --------------YFWLPTIFFGSMTGC---------KELF-QL--YC----------------------- NPHEYV-T----------DVENYAHL-F----------------------SVVGMVLVI------------- -------------P-----------------RN-KDGY-----VS-DWQT--------HVA----AVVIIVA WINLMLHIG----------------------------------------------RFPAFGL--YIQMFTTV AW-NMSKLLVTYFCLIVGF--SLGFAVLF----------------------PK------------------- --SKF-------------------------------------------FGE-I------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------PIA----- ---------------------LLTAIVMMTGEMD--FNALFYD----------------------------- -------ENGTE-KIR-------------------------F---PGTTH----LVFLFFVLLIVIVLMNLL VGLAVSDIQGLLNSAGLNRLIRTTKQI------------------------ARMEIFIFFPWPIRL------ ------PQL-------------------------------WSKIPKR----------ECLQR---------- --KV-LVV----------------------------SPKAKRT--------------------YNF------ --------------------------KPNDPRDGR------------------------------------- -----------------FPQNT-KEGL--------LAI-------------------------AVERMASKK KGPYQ------------------------------YNA---------------------------------- ---------------------------------------LSV--QT-------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------NGEF---------- ---------------------------------------------------------------ITDVFHR-- ------------------------VD-----------------EL--------------------------F T---------------------------------------NYMSEIVTMNE--------------------- ------------------------------------------------------------------------ -----------KINEKLAL----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------LEDANRFRLPL----------------------------------------- --------------------------------------------------------------------IPAR KIV--------------------------------------------------------------------- ---------------------------EEFSH--C------------------------------------- ------------------DTAV-------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Dpul_Pyx3/1-940 -----------------MGKCESANGDH------------------QTCAAEEMRDNKEF-RTKSG------ -RFK-------------------------------------------------------------------- ------------------------------------------------------------------------ --ARKYANRRAFQ----------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------DRRK-------- -------------------------------------------PWTTTNGA---------------ANSDAV GDTFRFDIP------ADDP----------------------------------------------------- --TFSISSESNTSRAE-------------------------------------------------------- ---------------------------------------------LKNCTI--------------------- ---------------------------------------------------SGE------------------ ----------EPASWF-------YG----------------------------------------------- ------------------------------------------------------------------------ CSIWTENQL----------------------------------KNSID------------------------ ---------------------E-LL--------------------------------GSH-E--------MD SIHPK------------------------------------TILGASESSRNWS-K-LPLCF---------- -------------------------------------------YNVAVLYASMTGNIVMLQFFLQR-GASP- ---KAID-S--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------EER--------------------------------------------------------- TALHY---------------------AASSSAV--TAADCITLLWE--------------------YG-AE- ---------IHAWDK---LGL--------------------------------------------------- -----------------------------------ATPL--ICAAASGNAEAVKVLLC-------------- --------------------------------------------AGA--EVNAGLADP------KYPD-SST PLIWAVRARS-------------------------------------------------------------- ------V------TCATYLIE-----------------------------GGA------AV----------- -----------------------------NS-P-----QAYSE-------APIHVAAA-------------- ---------QGDTDLL--------EMLLQN-KAD-IRVLF-------------------------------- ------------------------------------------------------------------------ ------GRERMSAL--------HLAAE---------EGNAGCIR---------------------------- ------LLL---------QAKADCNAVN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---FRGQTPL--------------------------HLATLS----Q------------------------S VESVA--------------------------------VLLEA-G--ARHN-ICDN-------DQK------- --------------------------------------SPLHSAIIK----------TSRSTEI-VRLLIAS GAD------------------------------------------INGRDN-F------------------- --------------------------GCT------------------------------------------- --------------------------------------------------------------------PLHL AA------------------VNENS---------KAATVLVQSGADLSA-KTK------------------- -GGVSALDFL-------------------------------------------------------------- -------------------------------VR--RTP-DVLTTIPRRLDSAVVVADH--------DPVDPD CELHLDFNV--------------------------------------------------------------- IVPSGD-----------------------------------------QQRVGESGFLITLVAAG-Q-----R HILQHPIIR-----------AFLHLK--------------------------------------WI------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------K------------------- ----------------IRSL-----------------FIVSLLFHAAFVLSLSANI-------------LSI Y-------------------------------------------------VIQRN----------------- -RNCS--------VIHNDSS-------T---TT---N---------------EDLN---------------- ------------------------------------------------------------------------ ------WDTTNCLYTQWPS----------------------------------WLE---------------- -------------DVVRYLNLGFGVLSLI---------KEFF-QL--LQ----------------------- TPSEYV-R----------SSENYIQC-F----------------------LIIGVVGIN------------- ------------LP-----------------KN-FN-------HN-DWQQ--------HLA----AIIIVVA WMELMMHVG----------------------------------------------RFPVFGL--YVQMFTTV AA-NIAKFLAAYMSLIIGF--SLGLSVLY----------------------PD------------------- --TES-------------------------------------------LAS-L------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------PFS----- ---------------------LVTTVVMMTGELE--YSKYFYE----------------------------- -------DH----RPE-------------------------Y---PITTL----IVFLAFLLFIVVVLMNLL VGLAVSDIQGLRKSAGLDRLVRQTRLI------------------------ARMESIVFSPWLNQL------ ------P-C-------------------------------WFDARTR----------KFLQR---------- --KI-LVV----------------------------PPSHHRV--------------------YTV------ --------------------------RPNDPRDNR------------------------------------- -----------------FPPDI-KENI--------LKI-------------------------LVSK-PNKK SYHEL------------------------------YRT---------------------------------- -------------------------NI----------EHQSS--LT-------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------E-----------------EL--------------------------F D---------------------------------------EF------------------------------ ------------------------------------------------------------------------ --------------DGESF----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------L--------------------------------------------------- ------------------------------------------------------------------------ KTR--------------------------------------------------------------------- ---------------------------ES-----M------------------------------------- ------------------DCY--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Dpul_TRP/1-1111 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --MG------------------------PP---------------------------------------VE- ----------SILKNE--EK---------------------------------------------------- -------------------------------------RY--LLLVERGDFNGVRSLIE--DYKD-------- --------------------------------------------RPNDLNLNCTDP-----------L-GRT SLVIAI------------------------------------------------------------------ --ENESY------ELLEVLL-E------------------------------------GGI----------- -----------------------------KV-S-----------------DGLLHAIS-------------- ---------EDYVEAV--------ELLLEW------------------------------------------ ------------EE---------------------------------------------------------- ------------KN--------HKDGTPY---------SWETLD---------------------------- ------S-------------ENATFTPDI------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------TPL--------------------------ILAAHR----N------------------------N YEILK--------------------------------LLLDR-G--AALPMPHDV----------------- ------------------------------------------RC------GCDECIAS-SKADS-LRHSRSR ---------------------------------------------INAYRALAS------------------ ------------------------------------------------------------------------ PSLISLSSK----------------------------------------------------------DPV-- ------------------------------------------------------------------------ ---LTAFELSNELHRMSI------------------------------------------------------ -----------------------IESEFTVDYK--QLEEQCQKFSTSLLDHVRSSYE--------------- LETLLNY-----------------------------------------SH---------------------- --DSE-EV-------------------------------WEPG------DRQTLDRLELAIKYT-Q-----K DFVAHANVQ-----------QLLGAI--------------------------------------WY------ ----------------QGLPGFRRRSAIGQIVETLK--IAAKFPIYSM--LYMIAP---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------TSEKG--------KFIKKPFVKFICHSASYLFFLSLLGLAS--------------QR VEYLLI--------------------------------------------EW--F----------------- ---------------------------G-------------------------------------------- ------------------------------------------------------------------------ ------TEWMQEIMEDWKR----------------------------------------------------- ------RERGSIPGPIELFIMLYIFGHIW---------AEVH-SL--WSD---------------------- GLMEYI-T----------DLWNLIDFTS-------------------NSFFLAWIFLRGVAWFIVQREQWE- GLNP-------WYP-----------------RE-------------EWSTFDPMLLSEGMF----GAAMIFS YLKTVHVFS----------------------------------------------ISPHLGP--LQISLGRI II-DIIKFFFIYMLVLVAF--GCGLNQLMWYYADLTRKKCFCLP-------N-------GGPDWE------- NEEEA------------------------------------C-FFWRRFSN-L------------------- --------------------------------------------FE-------------------------- ------------------------------------------------------------------T----- ---------------------SQSLFWASFGLVD--LQSFE------------------------------- ---------------LQGI--------------------KGFT--RFWGL----LMFGSYSMINIIVLLNML IAMMSNSYAAIAERSDTEWKFARSKLW------------------------LSYFDD--------------- --GATVP-------PP--------------------FNIMPTPKSML----------------------NVC K--------------------------------KKQTEASKEK----------NQHKAEIRHMEVMRLLVR- --------------------------RYVTAEQKK------------------------------------- ------------SEEMGVTEDD-VNEIKQDISSFRFELLDIL------------------------RNNGMK CGDTEK-----------------------------AGNAA-------------GKKGRLRER---------- -------------------------RL------------KKG--FQ-----------------IGMVED--- ------------------------------------------------------------LISSVIAN---- -----------------------------------------------------------------ASA---- ----------------------------------DKGPVDVFG--------------KIAK----------- ---------------------------------------------------------------VMASRSSSK --------------------MKKR---------------NEWNAM-------------------------AA S-RASVRRNPI-GS---------------------------KAQSNQRWSQQS------------------- ------------------------------------------------------------------------ -----------LRRSIIESERENLL--SMDPER--------------------------------------- ---------IAEYN---------PR-LKEY------TPATRVAYAK------FKRNTLGVI----------- ------------------------------------------------------------------------ ----------------DE--NNQTGSKED------RKMEK-----KLK-----------KSTV--------- ----------SLKKLASDPDMKNKLIAAGVDESSET------------------KPNSHLE-TIVHLEENES VTPV----PPTPT---------------P-----TPKSPTPAPTPA------------------PPTPAPK- --S--------------------------------------------------------------------- --------------------------PTPAPT--PV-P--------------------------TPA----- ---------------P-TPVPA-SVPT--------------------------------------------- --------------------PTPKAATP----APSPSPTPI------------------------------- --------------------------------------------------PTVSGTVA-------------- ----------------------------------------------AAPPSPAPTP-TPTTLQPSASSR--- P----------------------------------------------------------------------- ------DERGRSP-----SPSPR---------------------PAASRPSSRP----T-TLKEGWF----- >Dpul_TRPA5/1-983 -----------------------MNNHI-------------------------------------------- -RME-------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------YMHLL------- -------------------------------------------PWRRHVNKE-------------------- --------------NGDEE------------------------------------------------L---- GLDDDNLSESET------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------HYHDI----------------- ---------NNPR----------------------------------------------------------- ------------------------------------------------------------------------ -----------GSVY---------------------------SKYSLNE----------------------- ---------------------------------------------------------GDL-K--------LL GFIREE-----------------------------------NGI----TEETDA-N---------------- -------------------------------------------------------------------GDKF- ---CSSTNQ--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------RLM--------------------------------------------------------- --------------------------MAIEDRD--TG--AVEFCLK--------------------SG-AD- ---------PNHQYG---TNK--------------------------------------------------- -----------------------------------ITAL--HLATVGA-PEAVQPLLK-------------- --------------------------------------------YGA--DVKAADSRG--ITP--------L HLAAGMGSED-------------------------------------------------------------- ------L--------VQQLIE-----------------------------AGA------DA----------- -----------------------------NG-Q-----D--------------HVREN-------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------GGGQETPL--------HRAAV---------GGHLEALR---------------------------- ------QLI---------HGGAQVNIGE-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---ARGRTPL--------------------------HYAAQR----G------------------------A TGCIQ--------------------------------ALLDY-Q--ADPN-LTDK-------RGATALLLLG GGYLIKGHRRVSGYTESVETLIRGGAKVNVKDPDS-GVTPLHQAV------------TLGRLES-TKLLLAY GAN------------------------------------------LIAQDN-E------------------- --------------------------GGTPFH--------------------------------ACAIKGQA STLKYLLSQ----------------------------PGAKDAINLPDSKDR---------------MPLHK AA------------------YRGSA---------ECIQLLLKAGADLGA-KTK------------------- -TGLSAATLI-------------------------------------------------------------- -------------------------------LQ---LP-NGAKILSKRLDESIISNGI--------DPSEVA CRIKFDYSV--------------------------------------------------------------- LLTK--------------------------------------------HKFQQMGVIEDIMDDR-RQR-RTA DLLQHPVIE-----------SFLFLK--------------------------------------WR------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------K------------------- ----------------IRFL-----------------FFSNIILYLILVAGVSAYV-------------LSS --------------------------------------------------VWN------------------- ------------DPGPSSAT-------T---TT---VPPLNL----------SETV---------------- ------------------------------------------------------------------------ ----AGSDV--------QVTNR--------------------FASEPE----SVMQL--------------- -------------QLSLNIVI---LIIIF---------QEVI-QF--TS----------------------- LHYQYF-R----------EPESWIKIGA----------------------LVTSTIVIFSAP---------- -------------------------------------------PWPDWVH--------HVS----AVAVLLG WSEVTLLLG----------------------------------------------RLPTFGV--YALMFYAV AQ-HLVKFIFVFFFFLAGF--SFSFHLIF----------------------K-------------------- -------------------------------------------DRHEAFGS-P------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------WTS----- ---------------------LLRTFAMMIGDTG--YDEYLTEGNFN------------------------- -----------------------------------------L---QGTAH----VIYFFFLILVSLILMNLL IGLAVNDIQGLQNEGRVKRLRKQAEYI------------------------VYLEDIVSNRFLRWLLF---- -----CS---------------------------------GIMQWLN----------SWINL---------- --E--PVFTFSP-----------------------AGRKMKTV----------------------V------ --------------------------LPSSTVERA------VVIVQEGRAP--------------------- -------------LESMTISDT-YNLL--------HECVAS-------------------IGTLRQRIESLE QGLVGSSTAV--------------------PLPDSGSS-------------ENVEHKGDSGVAQDQDSGENH EDSDSSVS-----------------EL---------DYPK------S------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------HKGEADG--------------SGDHLDGP---------- ---------------------------------------------------------------YGRLGRS-- ------------------------LSRKTTKTTVLK------RSI--------------------------- ------------------------------------------QSELMDIKR--------------------- ------------------------------------------------------------------------ -----------MLITLTSQND--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------ISP ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Dpul_TRPL/1-1243 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------M-HA---------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------SSVP----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------RAI------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------EDA---------------- ------------------------------------------------------------------------ ---------------------C-MPILP-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------KSLTLE--EK---------------------------------------------------- -------------------------------------KF--LLAVERGDLTTVKRIIH--RVKRG------- -------------------------------------------LCGNSINLNCVDP-----------L-GRG ALLMAI------------------------------------------------------------------ --DNENL------QMVELLV-V------------------------------------MGI----------- -----------------------------AT-R-----------------DALLHAID-------------- ---------KEFVEAV--------ELLLEH------------------------------------------ ------------EE---------------------------------------------------------- ------------LI--------HKEGDPY---------SWENVD---------------------------- ------R-------------TTSSFTPDI------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------TPL--------------------------ILAAHR----N------------------------N YEILK--------------------------------ILLDR-G--ATIPVPHDV----------------- ------------------------------------------QC------GCGDCIRG-VLEDS-LRHSMSR ---------------------------------------------INAYRALSS------------------ ------------------------------------------------------------------------ PSLIALSSN----------------------------------------------------------DPI-- ------------------------------------------------------------------------ ---LSAFELSVELKRLAY------------------------------------------------------ -----------------------LETEFRQEYM--DLRRQCQQFACDLLSHTRSSSE--------------- LAFLLNH-----------------------------------------D----------------------- --PHS-HSSSL--------------------------RDIDNV------QEMKLTRLELAIDQK-Q-----K MFVAHPNIQ-----------QLLAAI--------------------------------------WY------ ----------------EGLPGFRRKSPLQKLAEITL--VALLFPLYCG--LYMIAP---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------LSSYA--------QLMQKPFMKFLIHASSYLFFLFLLILVS--------------QR FDVLVV--------------------------------------------EL--L----------------- ---------------------------G-------------------------------------------- ------------------------------------------------------------------------ ------TETMRKNLEDQLR----------------------------------------------------- ------RQRGNCPTFLECFVAVYVIGYVY---------EELH-EM--WKN---------------------- GVGRYI-R----------NLWNVIDVCR-------------------DLSYLLAMGLRTVAYIQQQNEIRDN PAAA-------YIP-----------------RE-------------EWDAFDPQLIAEGVC----AMANIFS ALKLVHLFS----------------------------------------------INPYLGP--LQISLGRM VI-DIVKFFFIYSLVLFSF--ACGLNQLLWYFSDLEKQKCFVLP--------------GGLPDWS------- KNADA------------------------------------C-AKWRRFAN-L------------------- --------------------------------------------FE-------------------------- ------------------------------------------------------------------S----- ---------------------SQSLFWASFGLVD--LGNFE------------------------------- ---------------LAGV--------------------KSYT--RFWGM----LIFGAYSVINVVVLLNLL IAMMSNSYSLITEHSDTEWKFARSKLW------------------------MSYFDST-------------- --GHTLP-------PP--------------------FNLIPTPKKIM----------------------RLF -CRK----------------TSKSS-------GKLRRTSTKGR------------RERDYCYTAVMRSLVW- --------------------------RYVTAMHRQ------------------------------------- ------------QEMSQVTEDD-VNEVKGDISTLRFELLDVF------------------------KNNGMD ISSANK-----------------------------NSKA------------ALGRKMRIWER---------- -------------------------RL------------LRD--FH-----------------VVSVAG--- ----LD---------------------------------------EEDQDESN------------------- ----------------------------------------DWSGR--------------GSSNHGEEG---- ----------------------------------KDNAADKFR--------------KLAS----------- ---------------------------------------------------------------VAVAMNVAG ----------------------------------------ISPAVA---------------------CVKGR T-IKPLSQI---GK---------------------------SMSNESFKSSQN------------------- ------------------------------------------------------------------------ -----------LRKAMEEAQRLTVV--SPTPE---------------------------------------- -----------PSP-------QHGK-YSDTEITV-DSGSSVLELLR------SMSNEEMRE----------- ---------------------------------------------------------EDL------------ -------EEEEEEVQNDR--HYDKENDKKK--EP-FPFS--------------------MKNMQSNQLA--- ---AAAA--------ATSSSTASKRDEVDVKKPSANVDSAAQE-AKI---------------------QFRP TKKA----PSPPLP------------DLK------PTNVASTPTTEVTT-SNSRN---ISALPTKMESKPSH NNTGVALS---------------------EDKVSLKSEVQQQDSKRTNIGG-----------------SGLM LS-----------------------GITNVAS--SR-A--------------------------TVQ----- ---------------E-ADYAT-TVSKKEII----------------------------------------- --------------ATGDTPAAGISKSSSSS----E------------------------------------ ---------------------------------------------------SGVPSSS-------------- ----------------------------------------------TAPNTQQS------------------ ------------SDSP------STDAVAAADRKLPIPSQNPPVA---------PIVK--------------- ----------KPPPKPEDGPANPT---------------EKPTNADGVKTV-------KRENSKGWF----- >Dpul_TRPM1/1-1141 ------------------------------------------------------------------------ --MY-------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------IEENQLAVTSASGVV---------------------- -----------------------------------------------------------FAIP--------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---PGHPG---------------------------------------------------------------- ----------------------------------------------WIESTFCKRE----------CSR--- ---------------------------------------------YVCSSD-KGP----------------- --LCTCGRTWTYHKTHG-IKNVGLS----------------------------------------------- --EEVWSPVHHT---------------------------------------------------ISSPTDAYG TIDFLGGPHP--------------------------------NKAQFIR----------------------- ------------------LGFDSRPDQIFQL-LTRE--------WGLELPKLVISVHGGK-V-----NFKLN PRLKL---------------------------------VFKEGLLRAAKTT--------------------- -----------------------------------GAWILTGGTSTGV---------------THHVGDAL- ---ISERSPRL------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------RSG---------------- ------------------------------------------------------------------------ ----------------------RVVSIGV------------------------------------------- ----------------------------------------APWG---------------------------- --------VVENRASL-------------IG-----RK---------------------------------- KDVAY----QSID--------------HPRSKFAALNNRHSYFLLADNG-------------TVGRYG-AE- ---------IALRRKL--EK-------------YISSQRLPARTNC-------------------------- -----------------------------------SIPV--VCLVVEGGMDTIRTVLE--YVTDSP------ -----------------------------------------------PVPVVVVEG-----------S-GRA ANLISFAHKYAKEM----EESSTALDGIREQLLAEIQKTFNISQSQTNK-------------LLAELLQ--- --CVENV------DLITIFKPSES------------------------SESKSL----NQL----------- -----------------------------DR-A-I--------------LCALFRARY-------------- ---------LTAAE----------QLSL-------------------------------------------- ------------------------------------------------------------------------ ------------AL------------------------AWNRVD---------------------------- ------IA------------RSEIFIYGQEWA---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------DGAL----------------------EEAMMEALVK----N------------------------C VDFVK--------------------------------LLLET-G--VQMARFLTI--------ARL------ --------------------------------------EELYNS-------------KQGPANT-LRYIVRD --------------------VRP-HMQRNYSFTLIDIGLVINKLMGGAYRCSYT-----------RRKFRHS YTDMMKNSTKETPS------RNILNHGLSE------------------------------------------ SGHLSLV-----------------------------------EDLQYHVEPSHNM---------FT-QPFNE LLVWSV--------------LTKRQ---------DMAKLMWHHGEESLA----------------------- -KALVASKLYQAMAIEAADD---------------------------------------------------- ----------------------DLEVEISDELR--SYAKEFDREALELLDYCYRQDDD-------------L AMQLLTCELS-------------------------------------------------------------- -------------------------------------------------NWSRQTCLRLAFACN-H-----R ELLAHPGSQ-----------LILGDL--------------------------------------WL------ ----------------GGLR--TRRSTNLKIV------LAIICPPLIL--QLEFK----------------- -SKKELQLMPQTEEEHMI------------------------DLKD---DLN-------------------- -----DEGDP----------------------------SEMNHHSSSCSSSPIVPT-QTDHIKA-------- NKAKRANTF-----------------------KCVEPSNTLHRH---------------------------H QLTFT-----------RKLL--------EFYAAPITKFWTWTIAYFFFLAVYTYTL-------------LVR TPP--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------NPEWNEYYVIVYIASFGS---------EKIR-EI--LAS----EPV-----------NLKR KLLVWA-S----------SMWNCCDAFF-------------------IVEFFVGMILRNH------------ -------------------------------------------------ENT-LNHGRVLY----CLNIVYW YIRILTILR----------------------------------------------VSRFLGP--FVTMIGWM LQ-RMVYYVTLMLVVLMSY--GVFRQSVLFPH-------------------EE------------------- -------------------------------------------FSWFLVRD--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------V----- ---------------------FFKPYFMIYGELF--ADDIN---------------PPCGNG-TNPD----- ----GSFNPDMPP-CETGR---------------------------WLNP----LLMTAYLLMINILMLNLL IAVFNSIFLKTNVHSHKIWKFNRFAVV------------------------MEYDQK--------------- ---PALP-------PP--------------------FIVMNHFRLFTQ----------WCRR---------- --RY----------------AG-------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------SFS-------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------KLF-------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -C---------------------------------------------------------------------- ------------------------------------------------------------N----------- --------------------------LN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Dpul_TRPM2/1-1137 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------MPP---P---- ------------------------------------------------------------------------ ------------------------------------------------------------------------ LLRPGDPL---------------------------------------------------------------- ----------------------------------------------WVEQSFSKRD----------CSR--- ---------------------------------------------FVTSTK-EVS----------------- --LCACGQTWAYHKTHG-VDSVGEP----------------------------------------------- --GEAWAPAFHT---------------------------------------------------TSSPTDAYG TIDFLGGPHP--------------------------------NKAQFIR----------------------- ------------------LGFDSRSDLILQL-LTRE--------WGLELPKLIISVHGGK-A-----NFELH PRLKR---------------------------------ILRKGLLRAAKTT--------------------- -----------------------------------GAWILTGGTSTGV---------------TRHVGDAL- ---ISERSPRL------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------RGG---------------- ------------------------------------------------------------------------ ----------------------RVVSIGV------------------------------------------- ----------------------------------------APWG---------------------------- --------VVENRASL-------------IG-----RK---------------------------------- KDVAY----QSID--------------HPRSKFAALNNRHAYFLLADNG-------------TVGRYG-AE- ---------IALRRKL--EK-------------YISSQRLPARTNC-------------------------- -----------------------------------SIPV--VCLVVEGGMHTIRTVLE--YVTDSP------ -----------------------------------------------PVPVVVVEG-----------S-GRA ADLIAFAHKYATET----GESSTVLDGMREQLLAAIQRTFHVHQSQADK-------------LLAELLQ--- --CVKKK------NLITIFRPSDN------------------------TATSDVIGDGHEL----------- -----------------------------DH-S-I--------------LSALFRARH-------------- ---------LSAAE----------QLCL-------------------------------------------- ------------------------------------------------------------------------ ------------AL------------------------AWNRVD---------------------------- ------IA------------RSEIFVYGQEWA---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------DGAL----------------------EEAMMEALVK----N------------------------R VDFVK--------------------------------LLLET-G--VQMARFLTI--------ARL------ --------------------------------------EELYNS-------------KQGPANT-LRYIVRD --------------------VRP-HMPRNYSFTLIDIGLVINKLMGGAYRSSYT-----------RRKFRHN YTVLMK---KPTP---------IVQSALAR------------------------------------------ ----SLM-----------------------------------DESQCHAEASFTL---------FSQQPFNE LLIWSV--------------LTKRQ---------DMAKLMWHHGEEALA----------------------- -KALIASKLYRAMASEAADD---------------------------------------------------- ----------------------DLEVEIYDELR--SYAAEFDREALELLDYCYRQDDD-------------L AMQLLTCELS-------------------------------------------------------------- -------------------------------------------------NWSRQTCLRLAFACH-H-----R ELLAHPCSQ-----------LILGDL--------------------------------------WL------ ----------------GGLR--TRRSTNLKIV------LAILCPPLIL--RLEFK----------------- -SKEELQLMPQTEEEHMI------------------------DLKDEGRDNN-------------------- -----TSSDH----------------------------SSSN--SSSASSSPSSSP-RSER-KN-------- NTSKEQIVY-----------------------EVVDPGVIYERRR-------------------------MR QLRIK-----------RKFY--------EFYAAPITKFWSWSMAYFFFLIVYTYTM-------------LIR TPA--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------TPEWNEYYVILHMASFGG---------EKVR-EI--MSS----EPV-----------KLSH KISVWA-S----------GVWNCCDAFF-------------------VIEFFIAMVFRLQ------------ -------------------------------------------------EET-LEIGRVLY----CLNIVFW YIRILRILQ----------------------------------------------VSKFLGP--FVTMIGRM LE-KMIYYITLMLVVLMSY--GVFRQSVLFPH-------------------EE------------------- -------------------------------------------FSWFSVRD--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------I----- ---------------------FFKPYFMIYGELF--AGDID---------------PPCGNG-TKAD----- ----GSFDPEMPP-CETGR---------------------------WLNP----LLMTCYLLVANILLLNLL IAVFNSIFLRTNVFSHQIWKFNRFNVV------------------------MEYEQK--------------- ---PALP-------PP--------------------LIIFSHLYLLVK----------WCRR---------- --CS----------------KG-------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------TKSD------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------KLLKRN----------------------------------------------------- ------Y----------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------S NC---------------------------------------------------------------------- ------------------------------------------------------------N----------- --------------------------LKCF------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------VSFH---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Dpul_TRPML/1-673 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------MATLVASASA------ ------------------------------------------------------------------------ -----------------------------------------------------------------------V SSH--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------A-------------SVQPEEN-- --------------------------------------------NVYND----------------------- --------------------------------SLSF---------------------SNN-Q---------- --------------------------------------VIGKRRVSQDLKG--------------------- ------------------------------------------------------------------------ --ISTTNSTTV------------------------------------------------------------- ------------------------------------------------------------------------ ----------------------------------------------------VSSP---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------SQSF--------------------------------- PVLGN---------------------EV---------------------------------------G---- -------EWVSNQNQLVFEYNGEM-------FTATSTNSTAEYGVTM------------------------- -----------------------------------DSPLFAQRH--SPAEERLKRRLR-------------- ---FF--------------------------------------------FLNPVQKWA---------ATRRF PFKLFT------------------------------------------------------------------ -------------QIIKIIFV--------------------------------------------------- --------------------------------T-V---------------QLCLFASFR------------- ---------DSHVFYARNTEVVFSHLFLQEWDVT-------------------------------------- ------------RE---------------------------------------------------------- -APPYPPAAGPLAV-------------------YSKKQFHEYLD---------------------------- ------FAIENYINLETSSMGAY-F----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ HLKNSKGSWITYCQTDYIRS----------------QFEPNS----N---------------EFKFD----S -NTKQECVEIP--IDADVS-----------DFKSED-FLREK-N--ITV----SG----------------- --------------------------------------LSLVEAT--------------------LMFSIKA IHFKP-------------------------------------NGPLNGPDC--------------------- ------------------------------------------------------------------------ -------------------------------------------------------------------YSFDL GLL-----------------FNNQG----------------------------------------------- EDGQLLVSLT-------------------------------------------------------------- -------------------------------------------TLAKHLD-CHGKVNPPV-----FDGPSKS FRSTVNILVI-------------------------------------------------------------- -------------------LICGF-----------------------------------------SFFLCAR AVIKAQLLKWETS-------DFFQRHFNRRMSKHDRLEFLNL----------------------WY------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------VLIIIDDVLLVG---G-----SIIKELM--------------------------- ENQHID-S----------DMWDVCSVLL-------------------------------------------- -----------------------------------------------------------------GTGNLFV WFGVLRYLG----------------------------------------------FFRTYNM--LIVTLKKA FP-SVLRFLLCAMLIYAGF--TFCGWLIFGPYH--------------------------------------- --------------------------FK--------------------FQT-I------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------SST----- ---------------------SECLFSLVNGDDM--FATFAGMSE-R------------------------- ---------------------------------------SALV--WWFSR----LYLYSFISLFIYVVLSLF IALIMDTYETIK---------------------------------------MYYTDGF-------------- ------P---------------------------------------------KSDLRQFIA----------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------NDDC-VDTIP-------------------------------------------- ------------------------------------------------------------------------ --------------------------V-----------------YESQSC---------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------FP-- -----------------------------------------QLW---------------------------- -------------------------------------------SLLTR------------------------ ------------RRP--------------------------GYEVIDDGR---------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------KDEEAE ERQ--------------------------------------------------------------------- ------------------------------------------------------------------------ ---------------P-------------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------------------ILA-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Dpul_TRPgamma/1-1185 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------MKTHD---------------------------------IDLQET-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------M-LA---------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------HTTPM---------------------------------------------- --------------------------------------------ECQ------------------------- ------------------------------------------------------------------------ ----KNSGKSE------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------TYS---------------- ------------------------------------------------------------------------ ---------------------SSYEQCGL------------------------------------------- ----------------------------------------KIPA---------------------------- --------CTD-------------------------DA---------------------------------- EDML------------------------PH---------------------------------------KE- ---------MGQLSFE--EK---------------------------------------------------- -------------------------------------KF--LLAVERGDVATVRRMLQ--RARDT------- ---------------------------------------------N-YIDVNCVDP-----------L-GRS GLLMAI------------------------------------------------------------------ --DNENL------EMVELLI-E------------------------------------YRV----------- -----------------------------ET-K-----------------DALLHAIS-------------- ---------EEYVEAV--------EVLLDH------------------------------------------ ------------EE---------------------------------------------------------- ------------SF--------HKEGEPH---------SWEALQ---------------------------- ------P-------------DTATFTPDI------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------TPL--------------------------ILAAHR----D------------------------N YEIIK--------------------------------ILLDR-G--AKLPAPHDV----------------- ------------------------------------------RC------GCIDCVTS-RQEDS-LRHSRSR ---------------------------------------------INAYRALAS------------------ ------------------------------------------------------------------------ PSLISLSSK----------------------------------------------------------DPI-- ------------------------------------------------------------------------ ---LTAFELSWELRRLSF------------------------------------------------------ -----------------------MEHEFKSEYQ--ELRKQCQDFATALLDHTRSSYE--------------- LEVMLNH-----------------------------------------D----------------------- --PKG-PA-------------------------------FEHG------DRMSLNRLKLAIKYR-Q-----K KFVAHPNVQ-----------QLLASI--------------------------------------WY------ ----------------EGLPGFRRKNMLLQSLEVIR--IGVLFPLFSL--LYILFP---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------HSRAG--------KTLRKPFIKFICNSASYFTFLFLLILAS--------------QR IEMVFK--------------------------------------------NW--L----------------- ---------------------------G-------------------------------------------- ------------------------------------------------------------------------ ----QLPDCLEKWISDDVT----------------------------------------------------- ------TKRGAPPTMIEWLILAWVCGLVW---------SEIK-QL--WDV---------------------- GLQEYV-G----------DMWNVIDFVT-------------------NALYVATVALRIVAFYQVQKEMSKN ANSA-------SLP-----------------RE-------------EWDTWDPMLISEGLF----SAANIFS SLKLVYIFS----------------------------------------------VNPYLGP--LQVSLSRM VL-DIMKFFFLYVLVLFAF--SCGLNQLLWYYADLEKQACDAPR------------------QGK------- SDPDA------------------------------------C-IVWRRFSN-L------------------- --------------------------------------------FE-------------------------- ------------------------------------------------------------------T----- ---------------------SQTLFWAAFGLID--LDNFE------------------------------- ---------------LVGI--------------------KSFT--RFWGL----LMFGCYSVINIVVLLNLL IAMMNHSYQLISERADTEWKFARSKLW------------------------ISYFEE--------------- --GGTVP-------PP--------------------FNIIPTPKSVWY-------VFKWMYR-------QCV GQTF----------------SHKK----------EHMKTIR----------------------NIMRNLVR- --------------------------RYVTVEQRK------------------------------------- ------------SDNQGVTEDD-VNEIKQDISAFRCELIEVL------------------------KNSGMN TSTATG-----------------------------VGQG--------------GKKNRQKER---------- -------------------------RL------------MKG--FN-----------------LA-NVGGNA GTQPSGLTS---------------------------------STPS--------------LAGSTMNPAFGN --------------------------------------TCPRTSMQTLNETNVLAVVATQSNNKGNPL---- ----------------------------------MRSPITKLA--------------QLAR----------- ---------------------------------------------------------------LAGAKKVDS ----------------------KK----------------RWGNL-----------------------IEAA KSAKGVGRMWTRSR---------------------------SRSEDSV------------------------ ------------------------------------------------------------------------ -------------SSDGSGGTSSLA--PVDTEC--------------------------------------- ---------FNRTD---------------------------------------------------------- ------------------------------------------------------------------------ ------------------------KYTKSR--TG-YPMV----------------------HVTENELP--- ------------------EVLEESGIDYELSG-------------RM---------------------CMDS INNT----H-----------------------------------STISS---------IRQFRR-ACSEPAD QVT--------------------------------------------------------------------- --------------------------LILEAE--S------------------------------LT----- ---------------V-ENNDY-EGNKPASC---------------------------------------PP L----------VNTANAIQSSGGFDESSNAVGLRFRKGCDL------------------------------- --------------------------------------------------TTSI------------------ ----------------------------------------------AFPSSVRSRDWMAGQNLPDSQTL--- PFVDDAADTSTLSGSPMETASKCINGVSFGRQEC-VVHE--------------KVIRG-------------- ----------VQPLENS--------------------------------------------SSGGWL----- >Dpul_painless/1-956 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------MVFLV---------------- ---------------------------------------------PYPLVTLTRIY---------------- ------------------------------------------------------------------------ ---------------------------------------------------------------SSSPV---- ------------------------------------------------ER---------------------- --------------------------------LLSY-TRS-------------------------------R FKSGKV----------------------------------PNGIRINK------------------------ -----------------------------------------------VH-------------GFPH------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------DI----------------------------------------------------------- TCLQL---------------------AVQKGL-----LAFVELLLD--------------------AG-AE- ---------VN--DFN-TKRK--------------------------------------------------- -----------------------------------LSSI--HLAMKNNRPESLELLLR-------------- --------------------------------------------FGA--NVNQREG-----------E-GRT PLHILIG----------------------------------------------------------QWNK--- -SGFEE----FRWSYFDLLLS-----------------------------QPA-----IDI----------- -----------------------------NI-Q-----DNGEA-------TPLELAVH-------------- ---------KNLNQVV--------KKLFQA-GAV-VNQHV-------------------RRAMEEKMPDLLA EYPEDERAANNNPDEIN-------SDYLESEIWKALRNSNQERFQSLLDTVQAGGVGTSVN----------- LSTSTSDHNP-TLL--------QYACK---------WQMPWAVS---------------------------- ------SLL---------AARVDPNQTS-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --NMTSTPAL--------------------------MEAVLR----G------------------------N VEIVR--------------------------------MLVYH----PHI--LLDA-------VDH------- ---VHTG------------------------------QTALHKIAQKLH-DANSADEKARYVQC-LHILVSS SSIQSQ--------------SRD-----------PGSSTTFSSVNVNAQDA-F------------------- --------------------------GNT------------------------------------------- --------------------------------------------------------------------ALHY AAL------------------SGVE---------EAVLQLLSSGANLGI-KNH------------------- -LGETAVKRIM------------------------------------------------------------- -----------------------------------------PSTLETFLDSCIRSKDG-------EDVSSQN FSITFDYSL--------------------------------------------------------------- LAPPRPIPHPPQQLQPSETGITFSNHNDAVESISLHNSQDEEEK-----IFPECEALWHLSTST-K----HQ YLLKHPLVT-----------SFLMLK--------------------------------------WH------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------N------------------- ----------------ISKF-----------------YYMNLLVYALTMLVLSTYI-------------LLL HS------------------------------------------------GYEPE----------------- -S---------------------------------------------------------------------- ------------------------------------------------------------------------ ----------------LRI----------------------------------------------------- -------PLAILWYVLGFFITI----LLV---------REFF-QL--GI----------------------- APLRYL-F----------SPENYVELVM----------------------MGCTVAVLAHWDD--------- -------------------------------PD-------------PWR---------HVS----AIAILLA WTEGLLLLG----------------------------------------------RHPQLSI--FVTMFTTV SL-TFLRLLLWYSVLLIGF--GLSFFIVF----------------------GGE----NKAED----GKE-- AKESA-------------------------------------------FTN-I------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------PVS----- ---------------------LLKVVAMMSGELE--YGDLPFD----------------------------- ----------------------------------------AS---PFVSR----FIFLAFLFLITIVLLNLL NGMAVSDTQSIQSKAETIGYVSRVELI------------------------SYLESMLLGDPF--------- --HFLV----------------------DWPPFAFIRRHCPSFSPL-----------SSLMRG-KSLRRFIR AESAVLFYRC-----------------------------------------------LPN-KTFTV------ --------------------------YPRRNNINQI--SPINNPNEQ------------------------- ------------MRTFRLDEDI-IQNACQ---------------------------------RVQENKQQRS L----------------------------------------------------------------------- -------------------------------------HESNA------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------QI-- -----------------LSEVE-RLH-----------------SA--------------------------- ------------------------------------------LLLLQNQQSK-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------LFQMLQ---------------------------------------------- --------------------------------------------------------------------NGSQ QS---------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Hame1115635_TRPA1-like2/1-1185 -----------------------------------------------------------------------M AVHEKTQ----------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------IPLLQ------ ----------------------------------------------KMSRRA----------RRKHKKQARF GSDVAINIE-----STPSNAKKTRP-----------------------------------------VY---- ERSISVRERYSRVD-DTSNV---------------------------------------------------- --------------------------------RKYAEELLQKAVENDYD-GCQAL----------------- -------------------------LEKG-DNVN-----------VEDKETKSTA----------------- --------LHIATR---------NGQRDIVILLLSKGA---------------------------------- ----DCNAQDGT---------------------------------------------------GQSPLHLTA ------------------------------------------TKDHVDC----------------------- -----CEELLKCSN----LKVNIPNKTHDTP-LHQA-AKE-----------------GRI-D--------IC TMLLEHAD-I--------------------------------DVKAKNKIG--------------------- --------------------------------------------MTPLHLAAHENHKNVIQLLMNK-GANC- ---NTQDR---------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------NFH--------------------------------------------------------- LPLHY---------------------AAQKG-----FPESCEVLLSN------------------------- ---------IKSADR---EKQLKT---------HL------------------------------------- ------------------------KNG--------KTPL--MLAAQGGHHKCCVKL---------------- --------------------------------------------TNT--YINAKDK-----------V-GNT ALHLAAAGGY-------------------------------------------------------------- ------E------NTIAELLN-----------------------------MGA------KA----------- -----------------------------NT-Q-----NIKGS-------APVLDAAS-------------- ---------KKNAGCL--------KILVEK-DAN-LFFVGQQNKNVLHYAAEKNSVECLTYLLSL------- -----------------------------------------PNMKSLLD----------------------- ----KKDDNNCTPL--------HISIK---------REAVECAH---------------------------- ------ILL---------ENNASPVEQCIGGMTP-------------------------------------- ------------------------------------------------------------------------ --------------------------------LHLAADKGYISICEILLAK---------DE------VKVS QENDSKATPL--------------------------HLAALH----G------------------------S AEVCQ--------------------------------MLLRK-G--ARLS-ATDG-------EGR------- --------------------------------------TPLHIAS------------LKNYATV-VKLLTKK GAP------------------------------------------QRTKDD-T------------------- --------------------------GST------------------------------------------- --------------------------------------------------------------------ALHL AAS------------------KGSL---------ECCQVLAASAKAVCNDLDH------------------- -NGNRPLDRA---FEKKHDKAFEFLLLHMPYRE---HQEEFVLCLHEYMHTALTGNRITAVKAIIDSSWWEA GFTG----------ANGHH-----CLNFRQLVE--CH----PSLALKVQDKCVQHIND--------DAEVT- ----YDFRF------------LEDNYY-ILSAT-------SKLAKSPYEEK-----------SGRVCQNACQ FIEDSLK----------------------------------------WKNDHPLSL---MISHT-R-----H QLLHHPLVN-----------AWLLHK--------------------------------------WR------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------S------------------- ---------------YIYIV-----------------FLACLLLELIFVTCLIIFM-------------GYI D-------------------------------------------------NWM------------------- --------------NIERRC-------N---FT------------------REQFCEISDT----------- ------------------------------------------------LSQVHDLGLT-------------- SQP-LHGDVVTGGNTETITNSTDNIAIS--QFTGFPD------NAT-------LIEFAKC------------ ------NTGVPVKRGISCVLVIIMFMTLL---------LECN-YI--YR----------------------- LKKEYL-------------------------FVENL-MQILR--------VVFTIVVLIPGGS--------- -------------------------------------CEFHYNVLGVEQW--------ECG----ILALLVE WLYFINMLN----------------------------------------------QLPMISV--FMPITRSF LK-SFFKVLFYIIMLVFIF--AFIFHLLL----------------------RD------------------- --QAA-------------------------------------------FHT-V------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------PQA----- ---------------------MVKTIVWMLGDLA--YDDTFLN-DVP------------------------- ---------------L------------------------VY---PVMVN----ILFVLFVTTIGGFIVNLV VAQPSEKLNSFRDKAAFHRAASRCRLF------------------------LKLEVCF-------------- ------P--------------------------------------FF----------RKFRT---------- --RR-----------------------------------------------------------FF------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------VGEETTSNGS-IFLTK- -----KLL-----------------RL---DNEVK----EAE--PEN------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------SLQLQ----------------------------------- ------------------------------------------------------------------LLEQ-- ---------------------NKQMT-----------------AM--------------------LNL---- ------------------------------------------------QKEE-------------------- ------------------------------------------------------------------------ ------------IHDLKQQ----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------LNII------------------------------------------------ --------------------------------------------------------------------TKYL PGR--------------------------------------------------------------------- ---------------------------NRDS----------------------------------------- ---------------------IM------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Hame11167056_NompC/1-125 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------ALATELVAISAASSSPGLLLRAVDNRNVVLLDSLIEHE-Q-----K EVIAHPAVQ-----------RYLYDV--------------------------------------WT------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------G------------------- ---------------SLEWP-----------------AWKMVVLFFAFLFLPPVWI-------------FFS M----------------------------------------------------------------------- --------------PLGHMY-------N---EV--------------------------------------- ------------------------------------------------------------------------ ----------------------------------------------------PIVKFM-------------- -----------AYLVSHIYLLLLMILTVV---------TPLR-PI--------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Hame11277693_TRPA5-2/1-838 -------------------MVGGAPGHL-------------------------------------------- -GYK-------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------ALP--------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ TTSTKPQPQQATRN---------------------------------------------------------- ------------------------------------------------------------------------ --------------------------------------------------NHK------------------- ----------QPT----------------------------------------------------------- ------------------------------------------------------------------------ --------------R---------------------------NNHKQ------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------PT--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------RN---------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------NFTMAIEAI--NTAMID----------T-------------- --------------------------------------------SGK--TLG-GDA-G--FCAWD--P-DAA KLLKMVDSEN-------------------------------------------------------------- ------L------EGVQALLE-----------------------------AGV------HV----------- -----------------------------NG-H------------------------G-------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------GPFHETAL--------HRAAQ---------VRWATGVR---------------------------- ------FLI---------TSGASVYAKN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---QYGQTPL--------------------------HYAAAS----K------------------------S TACIK--------------------------------LLLE--S--GRPG-VLDH-------RD-------- ----TRGH------------------------------TPLHDAS------------ASGCVNA-ITTLLKA GAL------------------------------------------VRAKDG-N------------------- --------------------------GET------------------------------------------- --------------------------------------------------------------------PLHK AA------------------KAHSV---------PAMVALLNAGADMAA-CDV------------------- -NGESVISYT-------------------------------------------------------------- -------------------------------LH--HLP-G---TMDAVFDHCLVTNSN--------NINTKT LEVAMNFLP--------------------------------------------------------------- LTCC--------------------------------------------DDKNQVQNLQSFVGLG-H-----A KLLSHPLCE-----------SFLLLK--------------------------------------WM------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------N------------------- ----------------VRRL-----------------FLIEVVLYLLFALLTTTLT-------------FNK F-------------------------------------------------VWTSS----------------- -KA---------NATHNATH-------N---AT---DDPMT-------------LV---------------- ------------------------------------------------------------------------ ----NESADAWGKWAVEHVIIQDSDL---------------YLTSITQ----QIIE---------------- -----------------GIVITYLVIILL---------QQSL-AL--LQ----------------------- NKLDWF-K----------SLSAVLHVII----------------------TILVAAVILPVM---------- -------------------------------------------PY-EWQH--------HLA----SWLMLVM WTECMLLIG----------------------------------------------RFPNCGI--YVVMFTRV AK-VFLRIFLIYFCLLLAF--SAAFYVAL----------------------HY------------------- --SKEQK--------------EDC------------------DTEDLVFSS-P------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------VLT----- ---------------------FVKTITMMIGELD--FDDDFVRGLGH------------------------- -----------------------------------------L---VISGH----VIFLLFVILVSIILSNLL VALAVNDVQGLRNSAHLERLIKQTELV------------------------FHMEKNFS------------- -----------------------------------------TAAYLA----------SYIR----------- ------IHKLTN-----------------------VLMKLANICNY----DCCNTR-------VYI------ --------------------------LPNNPKKLN------KLFVIANKKY--------------------- -------------KETDLPSHL-LANV--------HQC-------------------------LRTRETE-- -------------------------------ANDSKSS-------------TRVKRGSRIRRGEYHRN--NE EDFKANLK-----------------EV---------EANMSE--MVS------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------EKME--------------------DMADS---------- ---------------------------------------------------------------HTRLNKR-- ------------------------LM-----------------EL--------------------------- ------------------------------------------ESKLDRVTS--------------------- ------------------------------------------------------------------------ -----------LLLQQVSSTAIITT----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------PTATTTASSSPF----------------------------------------- -------------------------------------------------------------------TTTTP TTP--------------------------------------------------------------------- ---------------------------STDAS--VGGGDGD------------------------------G ---------------G-DDT---------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Hame1131817_TRPMc/1-1512 ------------------------------------------------------------------------ --MGSHER---------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------PIS--------PFMPRSPRLPPVAESSPRPPD----- -------------------------------------------RWYDSSATT-------SAR-SRGDRS--- -----------------------------------------------------------------------R LREMSAHSRSTV------------------------------------------------------------ ---------------------------G--------------------GSVVSPMS-LDPF----------- ------------------------SSYKINDLNSFS---------MND-QRW-TLQRK-------------- -----KIGLKRRTKGA-------------------------------------------------------- ---QERRVKSRQ---------------------------------------TQDINLSF------------- ------------------------------------------MHSNFTRK------------------ECIR Y-------------------------------VKNANAKVEGSCYC-----------GLLQNEH----IPLS SLLTAPPPLKSEDGTLM---------------------NIQEKVDRKQQHKTSGLA-------N-------- ------------------------------------------NIFNTLS-SLTRGN---SVQLSSVAETSS- ---RP--PTAT------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------SK----------------- ------------------------------------------LSLQE------------------------- ------------------------LETGVGQGEDNSVF----------------------SRE--------- ------------------------------------------------------------------------ -------NILLANGVTS-------------------RSRCNVIQPSSRPNTLP-------RIVMPAPDSPWR QDTHL---------------------YELPTN----AYGSITFMNET-------------------AG-SN- ------------------------------------------------------------------------ ----------------------------K------PSKYV-RLSSTSNVKNVLTLLTDYWCLMDPNRPQL-- ---VISVTGGAKNFQLDGKKKEIFS-------------------SGLIKAVKSTNAWL-----------LTG GMHVGIMKSVGEAV-------------NRGQFIVKIKRKNFFSEERVHMIRGIRCLGVLPWGYIKNRES--- -LMNSDV---NQFTSVKYKVEENAAPLEPVSLDGDHTHFLFVDDGHRNVFRGV-----DDFRTRLEEG---- ------------IRK-----------------P-----EPEGL------GVPVVLLLLDGGVNSIIKCNLAL KRDIPIVVVAGTGRAA--------DLLAYA-----VSMTIHT------------------------------ ------------PS----------GRF----------IMRKGHRAQLVNRISI------------------- -----------TMR--------EIKSF--------PEKQ-KCAD---------------------------- ------LLI---------ECCTKVNMIT-------------------------------------------- ------------------------------------------------------------------------ -------------------------------IFDINSNEDMDKYILYALLTGE------------------D VTSM--QDQL--------------------------SLALLW----D------------------------R PDIAE--------------------------------CEIFP----AQKN---------------------- ---WPSGAL----------------------------EDLMTTAL------------LEEKVEF-VKLF--- -----------------------------------------------TMNGLVM------------------ ------------------------ADYLT------------------------------------------V KKLR----------------------------------------------------------------HLYN EACIPNSHLMRLLQRASQNNYH------YLFHVHNVLQAMMRRHHDDIYTSDTPQAQSDNPSINYLT----- -FEDPYMELLLWAIFSRR------------------------------------------------------ ------------------------ARLANYLWQ--RCN---SPLCAAIAASCLYQSLW-------RSLGAKN TDILEEYNKNKNTFELFAVNLLGVCYQ-------------------------------------QDVINALG LVERRNAKWG-------------------------------------NSDCLELAVMA-------ND----L IFISTPAAQ-----------ASVELN--------------------------------------WR------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------R------------------- ---------------GMSRA-----------------PFFAVMIANVFPLLIFWPR-------------FFR FQ---------------------------------------------------------------------- -KLGD----------------------NGGELT-----------------IPQKMV---------------- ---------------------------------------------------------------------V-- ----FYKSPISKFCAHSTA--------FVIFLIVYA--------------YVVLFDFKY------------- -----------EMSITEKFLFVWICIYVI---------DEIS-EI--ISE--------QSL-------TLRG KISDWA-G----------SVWNRFDIVA----------------------FFLAFLALGLRLHRQTF----- ----------------------------------------------KWGR--------IAY----AVNTNVF YCRLFRMYH----------------------------------------------VNYHLGP--KLVIFYRM IS-EVLVFLALLVIFILGY--GIASQALL-----------------------------------H------- PSRDA---------------------GS--------------------LNS-T------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------SVS----- -----SIMEDV----------LLTPYWQMYGELL--LDEAEGDDQEVCH----------------------- ----------QKSCLINEFC-TNATTTCKEKVSCVCESSKDY---SWVVN----LMLFFYLIIGNIMLLNLL IAIFTYVFDEVQENSMEIWKFEMLRLI------------------------REYDM---------------- -KPSLIP------------------------------------PFVVL---------EYIWR---------- VSKG-TWKLF----------CRKQREN------------------------------LEDYMKSTL------ --------------------------DSLRIFEKEAISTYLVRITLDEE----------------------- ------------CSVDNRVKRM-SEKIDK------------------------------ITKYIEQKGEMEE IEEDLE-----WI----------------IHETDGLKQNKG-------QSILLTNQSSEQQNTNIEKLISIQ HQKHPTDG----VQGRSR------VEVMMDGDDESNQEDENE--LEDPPA----------QEV--------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------SNKDIEKEIKLLQAK-VIGGRPYSSRSCAGT---------- ---------------------------------------------------------------PSIAHRRNM ---------------DHLAGLTTRLD-----------------DL--------------------------- ------------------------------------------HEQLHLSQTTF------------------- ------------------------------------------------------------------------ ---------NTMMKTIMAR----------------------------------------------------- ------------------------------------------------------------------------ ------------L----------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------DSIEGK I----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Hame11391935_Pain2/1-1001 ------------------------------------------------------------------------ --MA-------------------------------------------------------------------- ------------------------------------------------------------------------ --SGS------------------NL----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------SL-L-------- -------------------------------------------DTSSTHST--------------------- ------------------------------------------------------------------------ -PSSAHYSPPSSAHST-------------------------------------------------------- ------------------------------------------------------------------------ ----------------------------------------------PAAHSTPAA----------------- ----------SHSA---------------------------------------------------------- ----------------------------------------------------------------PTTPVVT- TVRWAEKRTALKGIV---------------------------MVADVEN----------------------- -----QKTPLVT-A----MELQSLKAGDVNTFLEGD-DDP-----------------GIR-N--------LI QKWGAA-------------------------------------------------S---------------- ---------------------------------------VW--------------------------RPLL- ---SDDQAA--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------HQT--------------------------------------------------------- TSLHV---------------------AAKKG-----ALKCLQVLLD--------------------AN-PP- ---------KDVLDAP-DHDG--------------------------------------------------- -----------------------------------RTPL--LVAVSEAQAEVVEKLLN-------------- --------------------------------------------AGA--HINARND-----------K-GQT ALHILTFAIS-------------------------------------------------------KGVK--- -NDGILD------KITDLLLS------------------------------HK------DI----------- -----------------------------D--L-----EPHAEL------TPLAVAASR------------L PQGDGAPRRGGLIKFC--------KKMVNA-GAS-LQENGGDG--------------TIEEILQG-----KR ALPSILMGG------------------------DRCPAPRRPAASEFLDMVLMGSGIQDIQVFLQNKSAEDA RAAVNSRLGKQTLL--------FYAAN---------ISNESLIK---------------------------- ------TLI---------EAGANAWAFE-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---ITHELPI--------------------------HRAAAR----GHLSIFNRIIDHMKGDKRSVDLREYT VSIVQ--------------------------------KLMEN-SKKQKVP-SPDI----------------- -----------------------------------------------------------SHLDC-LRRLMQD DVL------------------------------------------LNVNQEWM------------------- --------------------------GKT------------------------------------------- --------------------------------------------------------------------VLHV AAS-----------------FNNQE----------AMSVLLCKGSFLGA---------------RQTIAGK- -TQGIILESI-------------------------------------------------------------- ----------------------------------------LPATLERAMDGCITHQPANRDDGEPENVLNEE YTLKLDFHF--------------------------------------------------------------- LLPPVND-----------------------------------DIKKEVKSTNEVEALMDINRSKRH-----R QTIKHPLVQ-----------CLLYAK--------------------------------------WR------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------K------------------- ----------------ALPL-----------------YLLNLGLYFFFVIMLTGFV-------------YSM K-------------------------------------------------DLRVL----------------- -EAQAKM------AGNSGSS-------N---TT---LDL--------------------------------- ------------------------------------------------------------------------ --------------EEQIL--------------------------SQQ----TTVH---------------- --------------WLMGFLIPLTIYMII---------REMF-QF--FY----------------------- TKEVYL-K----------NIENYLEI-F----------------------LVVVVVVLWCTTL--------- -------GADVT-------------------------------------R--------HLA----AWAMIVA WYEFVLILG----------------------------------------------RAPPLAI--YITMLRHV SW-NFLKLIFLYGALILAF--TISFNIIL----------------------QP------------------- --TTDG--------------------------------------QDSDFSN-F------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------WST----- ---------------------LPKAIVMATGEFE--YSDLSEQ----------------------------- ----------FSRKLL-------------------------F---FTSAI----LIFLLFLFLIFLVLMNVM NGLAVTDTQQVVDDAKLYSLTSRLELV------------------------YLTESLFLSCPGLRSYV---- -------------------------------------------DKIHS---------KLGSK---------- --YWPILS----------------------------GSKKGSI--------------------LHA------ --------------------------YINNPKKEE------RLR--------SG------------------ -------------EEMQFCCTL-DNDIAD-CLRN-YRL-------------------------QCI------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------EDQK--------------------SRGDP---------- ---------------------------------------------------------------LNQFLPI-- ------------------------LQ-----------------EL--------------------------- ------------------------------------------QDIVRNHPQ--------------------- ------------------------------------------------------------------------ -----------LVQQAAST----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------VHPG N----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Hame11400866_TRPgamma/1-926 ------------------------------------------------------------------------ --MD-------------------------------------------------------------------- ------------------------------------------------------------------------ ----------------------------------------------EGDEETGG----------TDAR---- -------------------------------PRTMGGDVECGRGGVGG------------------------ --------------------------------------------------------GGG------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------GGGGL-LA---------------------------------------------------- ---------------------------------------------------------------PQPPP---- ------------------------------------------------------------------------ ------------------QPLRSNLL--------------------------------AL-S-----TADA- -------------------------------------------ANKE------------------------- ------------------------------------------------------------------------ ----AKNKNVK------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------SHS---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------IHG---------------------------- --------MGE-------------------------ED---------------------------------- RHNR------------------------PH---------------------------------------QE- ---------MGQLTIE--EK---------------------------------------------------- -------------------------------------KF--LLSVERGDVAGVRRMLL--RCSES------- ---------------------------------------------GIMMNLNCVDP-----------L-GRS ALLMAI------------------------------------------------------------------ --DNENL------EMVELLI-E------------------------------------FKV----------- -----------------------------ET-K-----------------DALLHAIS-------------- ---------EEYVEAV--------EVLLEH------------------------------------------ ------------EE---------------------------------------------------------- ------------TV--------HTPGEPH---------SWEAIP---------------------------- ------P-------------ETATFTPDI------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------TPL--------------------------ILAAHR----D------------------------N YEIIK--------------------------------ILLDR-G--ATLPGPHDL----------------- ------------------------------------------RC------GCEECVTS-RLEDS-LRHSRSR ---------------------------------------------INAYRALAS------------------ ------------------------------------------------------------------------ PSLIALSSK----------------------------------------------------------DPI-- ------------------------------------------------------------------------ ---LTAFELSWELRRLSF------------------------------------------------------ -----------------------MEHEFRSEYQ--ELRKQCQDFATALLDHTRSSYE--------------- LEVLLNH-----------------------------------------D----------------------- --PTG-PP-------------------------------HEHG------ERMHLNRLKLAIKLK-Q-----K KFVAHPNVQ-----------QLLASI--------------------------------------WY------ ----------------EGLPGFRRKNMALQALEIVK--IGLLFPIFSI--VYVLAP---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------HTSLG--------QTMRKPFIKFICHSASYLTFLCLLILAS--------------QR IETVIV--------------------------------------------DW--F----------------- ---------------------------G-------------------------------------------- ------------------------------------------------------------------------ ----ATPT-LKKWVATDVT----------------------------------------------------- ------TRRGAPPSLVEWLILAWVFGLIW---------SEIK-QL--WDV---------------------- GLREYV-G----------DMWNVIDFIT-------------------NALYVATIALRIVAYYQVQREIRKN LGTD-------NLP-----------------RQ-------------NWDTWDPMLIAEGLF----AAANIFS SLKLVYIFS----------------------------------------------VNPYLGP--LQVSLSRM VV-DILKFIFLYLLTLFAF--SCGMNQLLWFYADLEKQTCDEEG-QPQD--NMTSGSGSGDEDSG------- PNIDS------------------------------------C-IVWRRFSN-L------------------- --------------------------------------------FE-------------------------- ------------------------------------------------------------------T----- ---------------------TQTLFWAAFGLID--LTNFE------------------------------- ---------------LTGI--------------------KPFT--RFWGM----LMFGTYSVINVIVLLNLL IAMMNHSYQLVSERADTEWKFARSKLW------------------------ISFFEE--------------- --GGTCP-------PP--------------------FNTIPTPKSLYY-------LLHWFYK-------KFC GQTK----------------AAKK----------EHMRTIR----------------------SIMRNLVR- --------------------------RYVTVEQRK------------------------------------- ------------AENQGVTEDD-VNEIKQDISAFRCELVEIL------------------------KISGMN TSTATT-----------------------------SGQGIHP------RGSSGGKKNRQKER---------- -------------------------RL------------MKG--FN-----------------LG------- ----VNTLS---------------------------------TTQS--------------LGATTVL----- ----------------------------------------PATAE--------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------NNH--------------------------------------------LTY-------- >Hame11498999_Pain1/1-929 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------MS---------------- ---------------------------------------------GY--LALKSME---------------- ------------------------------------------------------------------------ ---------------------------------------------------------------GNGTAMQGG -------------------------------GSPGGD-----VEDHYVQE---------------------- --------------------------------MLVA-VQT-----------------GDE-E-------KLR FALKQL----------------------------------PAKC-VN------------------------- ------------------------------------------------H-------------VYPH------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------PVSA--------------------------------------------------------- TALHV---------------------ATQNES-----VELVRVLLQ--------------------AA-AD- ---------PNARDLR-SGRK--------------------------------------------------- -----------------------------------YCPI--HYATNNGNIEILQALLK-------------- --------------------------------------------AGA--DPNAKEG-----------EYGRT SLHILAT----------------------------------------------------------RW-K--- -TNEDN----FK-ACLDALLS-----------------------------CNK-----IKV----------- -----------------------------DT-V-----DSKKS-------SPLFMAAT-------------- ---------KSWEYMT--------RQMILK-GAN-VDAAVGK--------------KTARDVINKNLPCLL- -------------DTIDFSVIEKPQRYFSEELYDALVNHDLDLFREILDEINSSEEKSKA------------ -SILEEDHGEYTLL--------QYACD---------KGLPDFVE---------------------------- ------ELL---------KNGANPSRKD-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --DTNNNTPI--------------------------LYATRN----G------------------------Y HEIVK--------------------------------MLIKS----------LRE-------GRE------- ---LEKGA---------------------LKQADLLKETPLHKVVKREY-KLKN--EGVNYYKC-LELLLKE RRY----------------------------------------LDIDAQDS-F------------------- --------------------------GCT------------------------------------------- --------------------------------------------------------------------PLHY AVL------------------CDDQ---------SFVRTLLLNGANLGI-KNK------------------- -FGTLAITRIQ------------------------------------------------------------- -----------------------------------------ASVLEEVLNECIEHN---------RNVADRD FEIILRYSM--------------------------------------------------------------- LAP----------------------------------SQSSQQ--------PETECLRFLSASR-K----HR RLLLHPIID-----------TFLFLK--------------------------------------WQ------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------R------------------- ----------------IKQY-----------------YFFNIFAYTAFLILLTAYI-------------LIF HG------------------------------------------------SFIPA----------------- -SEEE------------TGQ-------N---NT-------------EVP----------------------- ------------------------------------------------------------------------ -DT-NSTATNLEMVREKMM----------------------------------------------------- -------ESMTVKYILKGLISLFALYIAV---------REGV-QF--FV----------------------- SWKLYV-S----------RLENWLEISI----------------------VLLTTILLFIPIG--------- -------------------------------AG-------------SLQ---------SLS----AWLILFS WIEFILLLG----------------------------------------------RHPYLAV--YITMFTTV TY-NFLKFIIMFSFMIIAF--SISFYLVF------------------------------------------- QVDDN-------------------------------------------FMT-Y------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------HQS----- ---------------------LLKTIAMTTGELE--YSELPLS----------------------------- ----------------------------------------AF---PVSSH----LLFVLFVFLIVLVLMNLL NGLAVSDIQQIQQEAEIVSFSSRVELI------------------------SYIESVFLGSPL--------- --QQIVPGP--------IKCCENG--GDDCHFVSCADSRNPVMRLL-----------NWLGR---------- --RTLMFQSC-----------------------------------------------LNDKHYITM------ --------------------------YPNRD-------------VERWS----------------------- -------VC--DCHTFHLKEAH-IEAAKD---------------------------------VVLEKEYAVA N----------------------------------------------------------------------- -------------------------------------HR--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------LTGLETRLD-----------------EV--------------------------- ------------------------------------------MAAISSLTEK-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------VNKHVL---------------------------------------------- --------------------------------------------------------------------CPSP Q----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Hame11524135_TRPML/1-727 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------MNAANH------ ------------------------------------------------------------------------ -----------------------------------------------------------------------A QCHRRRGSRDERGQGG-------------------------------------------------------- ---------------------------------------------EITNNSKPQQP---------------- ---------------E-------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------------------------------------RGEQEEE-- ------------------------------------------------------------------------ --------------------------------TTTA---------------------GDH-L---------- --------------------------------------LVQDGEEKQQSQ---------------------- ------------------------------------------------------------------------ --FPNPQQTDT------------------------------------------------------------- ------------------------------------------------------------------------ ----------------------------------------------------SMNRT--------------- --------------------------------------------MQI-----------K------------- ---------------------TRTSRAKP------------------------------RGRS--------- ----------------------------------------GSWS---------------------------- -------GVNESDDELE-----------KMAQAL-SQPP--------------------------------- PEIKV---------------------SSAEQN------------------------------GGSRYG---- -------SITSSINST-----GQC-------SPLDDSVTTNTTTGLF------------------------- -----------------------------------SPEV---------TSDRMRRRLK-------------- ---FF--------------------------------------------FMNPMEKWH---------ARQRF PWKLLL------------------------------------------------------------------ -------------QIFKIIVV--------------------------------------------------- --------------------------------T-A---------------QLCLFAQQR------------- ---------YNHVNYLWDTKISFSHLFLQGWDTT-------------------------------------- ------------ME---------------------------------------------------------- -IQVYPPPGGPLAV-------------------YKKSSFFEYLD---------------------------- ------YAAITYANIHDTAIGTYAY----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ MYKNDSIVSPTFCTTHYVSG----------------EAFLKN----N---------------SFILD----N -NTTKTCINIP-PSEANVT-----------HWSSKT-YLEQQ-N--FTL----NF----------------- --------------------------------------DLLLNAE--------------------FEFILRT IKLRV-------------------------------------SLPFDTPEC--------------------- ------------------------------------------------------------------------ -------------------------------------------------------------------YCMTS KVQ-----------------FNNHD----------------------------------------------- HDGQMLVDLQ-------------------------------------------------------------- -------------------------------------------VGAQVLE-CDGSVQVVS-----EAKTLRV WRMIINVTSI-------------------------------------------------------------- -------------------LICVT-----------------------------------------SLIMCVR AIYRAQILRKATA-------SFFHRHYGRELTLEERMEFLNL----------------------WY------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------VLICVNDILIII---G-----SFFKIGL--------------------------- ESKLFL-EEKERSYDGYLDTWNICSLFL-------------------------------------------- -----------------------------------------------------------------GLGNMFV WFGCLRYLG----------------------------------------------FFATYNI--MILTMKKC IP-NVLRFSTCLMMVFAGY--CLCGWLVLGPYH--------------------------------------- --------------------------LK--------------------FRT-F------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------SST----- ---------------------MECLYSLINGDDM--FATFSSTSG-K------------------------- ---------------------------------------DPVV--WWFSR----AYLYSFISLFIYVILSLF IAIIMDAYETVK---------------------------------------HCYDDGF-------------- ------P---------------------------------------------ESGLMKFV------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------NEC-TEEPSS------------------------------------------- ------------------------------------------------------------------------ -------------------------GV-----------------FHDDG----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------DRT----------------------- ------------------------------------------------------------------------ ------------IHDVINS----------------------------------------------------- ------------------------------------------------------------------------ ------------LFCCGLE----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------RNHQDM EYE--------------------------------------------------------------------- ------------------------------------------------------------------------ ---------------P-------------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------------------LIT-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Hame11672838_Nan2/1-628 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------MEGPIVDL------------------------------------- --------LK-------------------------------------------------------------- ------------------------------------------------------------------------ --------------------------------------------TKWETF---------------------- --------------------------------VKNR---------------------FNN-L-----FYVFL AYFLI------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------SMGAYV---------------------NRP--------- ----------------------------------------VPCV---------------------------- ---------SSWPGSVV-------------------KP---------------------------------L SIMKL---------------------PA----------LNIICVDV-------------------------- ------------------------------------------------------------------------ -----------------------------------AVKV--HPGV-----IIQDSGIT-------------- ---TD---------------------------------------PTSLIDVLTTPRIN-----------RSS VFEVDLDSSTSTS-------------------------------------------------SSYMTLE--- -PVGED-EGEVEPLLAVVTQD-----------------------------QGV------TSDDGLTYDGLTS DDSVTSDDGM---------TSDDGVTPYPDDYT-----VTVQYVV--DGE---QVSVT-------------- ---------LSSEVND--------LLTASV-TSD-------------------------------------- ------------PL---------------------------------------------------------- ----TSDQVNHLPL---------LFTC---------YNK--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------THDLEL----T------------------------A MNKTF--------------------------------FITKI---------IKRY-------WPNKP----- --------------------------------------PSAMAAV--------------------------- -------------------------------------------NPYILNITTND------------------ -------------------------TAKG------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -PCYCVL----------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------WR------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------A------------------- ------------------------------------------------------------------------ PE---P---------------------------------------------------------------RKG -EMKI------------------------------------------------------------------- ------------------------------------------------GGMY-------------------- ------SSEI-------------------------------------------------------------- ---------------YFYVRVVCEGLTFL---------GSLA-YL--IGA--------ANE-------ARFQ GGKMFV-E----------NLSTVPSRVL----------------------FLLACTMVMVMAVLRML----- -----------------------------CMSE--------------AED--------VVA----IMVMLCT GPYFLFFCR----------------------------------------------GFKTVGP-FVTMIYTML VG-DLLRFVTIYFVFIMGF--SQAYYIIF----------------------SSF------------------ QDI---------------EDRPMC--------------------VHNPMPT-A------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------SES----- ---------------------IMLMFIMSLGNFGDVYNALECT----------------------------- ----------------------------------------DH---EISGK----VLFMIFMAIVSLLLINLL IAMMGNTYER-IAEMKNEWMRQWARIV------------------------LVVERGLSPEERLKHLM---- --TYSQPMSDGRR-----------------------------ALVLRL---------HQN-D---------- -EER----------------EEMKDI-----------LDMKRV------------------HQKYVLRRKNR KNPFA------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------EFEDPT----------------------------------------------- ------------------------------------------------------------------PTVVRK E----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------PPKKV------------------------------------------------------- >Hame11722724_Pkd2/1-783 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------M-------------------- -------------------------------------------------SN--------------------- ----------PASELDR------------------------------------------------------- ------------------------------------------------------------------P----- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------G------QAWG--------------GAGGG GGPN-----------------------------------------------------------TAAVDNY-- ---EYDNNENN------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------SKK---------------- ------------------------------------------------------------------------ ---------------------GCWHSFST------------------------------------------- -----------------------------------------CVS---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------RM--WATRQMTKQEDREIYVR--TT-------LRE LV-----------------------------------------VYIIFLIILCILT-----------F-GMT SPTMYY------------------------------------------------------------------ --YTKVL------S--DLFL---------------------------------------------------- --------------------------------------------------DAPFPDTK-------------- ---------NTFRGST--------QV---------------------------------------------- ------------------------------------------------------------------------ ------------------------------------MDFWRFME---------------------------- ------NILL------DGLYWEYWY----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------DP---------------------------TPTPTE----E------------------------D DRNI---------------------------------LYENR-M--LGVPRIRQV----------------- ------------------------------------------RV------RNDSCLIP---ENF-QRAINQC ---------------------------------------------FDVYSD--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------AAIDTNSFG---NGKNSTAWTFYSEKEMNGSQH--------------- WGKIATY----------------------------------------------------------------- ---------------------------------------TGAG---------SYQDLGL-NKTM-T-----K AILA----------------DLRENL--------------------------------------WI------ ----------------Q-----RGTRVVFIDFTVYNA-NINLFCVIKL--LFEFPA---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------TGGVI--------PSWSFRTVKLLRYVTALDY--FILACEF---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------IFIFFIV-YY-------IIEEAL-EI--KTL---------------------- KCD-YF-K----------SVWNLLDLLV-------------------IAISLVCVGFNVYCILSIYHKLEEL LSDP----------------------------N-------------TFADFEFLGYWQMQFNNAVAVCVFFA WFKLFKYIS----------------------------------------------FNKTMTQ--LFSTLSRC AK-DVAGFTIMFFIVFFAF--SQ-LGYLLF--------------------------G--------------- -------------------------------------------TQVYDFSS-F------------------- --------------------------------------------IN-------------------------- ------------------------------------------------------------------A----- ---------------------MFTLLRTILG-------DFN------------------------------- ---------------FHEI--------------------EDAN--RILGP----LFFLSYVFFVFFVLLNMF LAIINDTYSEVK----AEIANQRNEFE------------------------IADYFK--------------- -------------------------------------------RGYNN---------------------MMG KLGK----------------RDKI---------IDLQNAIKLS---------DANNDGLITFDEIRVNLKKC NFS----------------------DMEIEMFFAK------------------------------------- ------------YDTDGNRMLE-EDEVKRMLADLEGQKVALDT----------------G-NSDENKQMKHE ERPGSGKSSSGAETRPMSAS---------------SGHGSIA------SV-SFEEFSVLQRRVD-------- -------------------------RL------------EHS--IG---------------SIVSKIDA--- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------VLVK----------- ---------------------------------------------------------------LDTMEKTKH --------------------KRRE----------------TMNKMMD-------------------TITEND GMDETTKRKNMEKL---------------------------VRSELEKWDGD-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------SPPL--------------------------------- ------------------------------------------------------------------------ ----------------------------------------------------------GQK----------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Hame11798817_TRPA/1-690 ------------------------------------------------------------------------ --MA-------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------GPTPIR--- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ EDLEN---------------------ALKEG-----HKARVASLIQN------------------------- ------------------------------------------------------------------------ -----------------------------------HSDL--------------------------------- -------------------------------------------LTSK----------------------SLP WLHLAVSAPK-------------------------------------------------------------- ----------NSSKLLRLLLK-----------------------------EGI------SA----------- -----------------------------DV-T-----DSSGA-------TALHLSAK-------------- ---------KGQKRCL--------VNLLEW-KAK-IE----------------------------------- ------------------------------------------------------------------------ ----CKDNLGRTPL--------HYAALCKH------KGVVACIQ---------------------------- ------VLL---------EAGAFLDASN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---KKGLAPL--------------------------HVAAEV----D------------------------N VTAAR--------------------------------IFLHA-G--ASQN-MVDG-------RGR------- --------------------------------------TPIHIAS---------------SIKM-TEILVLA GAD------------------------------------------MTTEDA-E------------------- --------------------------GQT------------------------------------------- --------------------------------------------------------------------PLYK AISHFP----------------------------SLVHTMLTSGVAVRG----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------DPCDSQ LGVYFNFNV--------------------------------------------------------------- --------------------IC-------------------------RPGNVEVKLLNALAHDD-H-----F DRLKHPLCE-----------TFLHLK--------------------------------------WL------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------L------------------- ----------------IRTL-----------------FCIKWAMFAFVVFALTINV-------------CLR V----------------------------------------------------------------------- ------------HLPLPQDC-------N--TSTY------------TVW--VNNKC---------------- ------------------------------------------------------------------------ ----------------------------------------------------SYIK---------------- -----------TAAVLRWLSLLMMSAIVM---------RTLL-QI--------------SV----------- KKSLFL-R----------RKDKWLEMVF----------------------IVCSIPLLVTEGR--------- -------------------------------LE-------------MWER--------QLG----SFTLLLG WYGVTMMVG----------------------------------------------HIPSVGI--YVQMFHAV AL-KMMKFSAVFLSLFVGF--AVSFHLSF----------------------VEVVA---------------- ------------------------------------------------FRT-A------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------WSS----- ---------------------FIKTLVMMVGELD--TAELFETSDSD------------------------- ----------QKIWVLPE------------------------------------LIFIIFVLLITVIITNLL VGLAVQDIQELQKVAGVSRLAHTVEQE------------------------ASFDYFLSSRLL------EC- ------PFS----------------------------------ANFL----------TWMKK---------- --RYSLLQQFPPIPLHEPSLKRLSSVWL-----SNQESEYKTFGH------------MDH-YNVVIFP---- -------------------------YDPTNPGRVYKYQQTTRKMV------------P-------------- -------------TSYSLPSWI-IRNTKK---------------------------------LIENN----- ------------------------------------------------------------------------ ------------------------PNIG-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------YRDAD----------------------------------- ------------------------------------------------------------------------ ----------------FIYGCDSDWD---------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------SSSD DSE--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Hame11852279_TRPM/1-1760 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------MAGMR-------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------WVETVFNKRE----------CIK--- ---------------------------------------------FIPSSK-DNA----------------- --RCVCGQLWQCHRDGS-PATLRHGE---------------------------------------------- --DIHWSPSRHT---------------------------------------------------QLLPTDAYG TLEFQGGAHP--------------------------------TKAQYVR----------------------- ------------------LAHDTRPEHILQL-LTGE--------WGLDLPKLLITVQGGK-T-----NFDLQ PKLKK---------------------------------VIRKGLLKAAKTT--------------------- -----------------------------------GAWVFTAGTNTGV---------------TRQVGESL- ---VSESPLRV------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------RSG---------------- ------------------------------------------------------------------------ ----------------------RVVSVGI------------------------------------------- ----------------------------------------APWG---------------------------- --------IVERRQDL-------------IG-----CS---------------------------------- KDVPY----HPIN--------------SPKSKFVALNSHHTFFLLVDNG-------------TVGKYG-PE- ---------LILRRKL--EN-------------YISKQHIKTRGGL-------------------------- -----------------------------------ATPV--VCVVIEGGPQTIRQVLE--YVTDSP------ -----------------------------------------------PVPVIVCDG-----------T-GRA ADILAFVHKYACSG-------LNMIEANRDTIILALERVFELRPVQAEK-------------LFAEVLQ--- --CVRKR------DLITIFRLK----------------------------------EGSEL----------- -----------------------------DQ-S-I--------------LSALLHAQR-------------- ---------LNPPE----------QLSL-------------------------------------------- ------------------------------------------------------------------------ ------------AL------------------------TWNRVD---------------------------- ------IA------------RTHVFNEEVEWS---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------QGAL----------------------EQAMMDALVN----D------------------------R IEFVK--------------------------------LLLEQ-G--VTMNKFLTI--------QRL------ --------------------------------------EELYNSV---SMAGDSVFHKCGPSNT-LRYIIRD --------------------VKK-NIPRDYRYTLIDIGLVVNKLMGGAYRSYYT-----------RKKFRTT YENTMMRSP------------HLHRNNSSI-----------------------------------------F QASKSLL-----------------------------------QKHPNTSPKSYICE-DLYCKFEFD-YPFSE LLVWAV--------------LTKRQ---------GMAMLMWQRGEEAVA----------------------- -KALVAAKLYKALAHEAADD---------------------------------------------------- ----------------------DLETEVYEELK--GYAKEFETLALEVLDYCYQQDDD-------------R THQLLTYELR-------------------------------------------------------------- -------------------------------------------------NWSKQTCLSLAVAVN-H-----R ALLSHTCCQ-----------ILLADL--------------------------------------WL------ ----------------GGLR--TRKNTNIKVM------LSLLVPPLIL--VLGFR----------------- -SREELKTMPQTREEHQDD-------------DPERSSDSESDSESEEENMD-------------------- --MR-HDHDPEAQLVNSVSLASHPVTPTLQTEAPLCN-NTAAPHSSTLVVPPSQPEGGADVVDQH------G TPVRQNGVSM---------------------SHLSHLDSTIFNDI------------------------HSR QLPAR-----------IKLY--------EFYNAPITKFWAHSMAYVFFLCLYTYIV-------------LVK LPK--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------QPEWMEWYVVAYISTLIL---------EKIR-EI--LST----EPV-----------ELKQ KIAVWS-D----------KLWNVCDMFF-------------------ALFFVVGLALRLQ------------ -------------------------------------------------EQT-MQAGRIIY----CVDIIYW YLRILEILS----------------------------------------------ANKYLGP--LVMMMGKM IK-NMAYFVVLLLVVLMAF--GVCRQSILFPN-------------------EE------------------- -------------------------------------------PHWRLARH--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------I----- ---------------------FYQPYFMLYGEVF--AGDID---------------PDCGG----------- -------E-GEIP-CHPGR---------------------------WITP----TVMSMYLLVANILLINLL IAVFNNIFTSVNAISRQVWMFQRFQVV------------------------MEFEGK--------------- ---PVFP-------PP--------------------LIILSHIHRVIK----------YCFR---------- --RW----------------KGKP---------FLYDNGLKIFLDG------ESLERLHDFEEECMDGYNR- -------------------------DKDQKEQMST------------------------------------- ------------EERVRVMAER-TEGLMQRIEDMHSKFVTAMS----------------SVNNLDFHVKRLE ETVEQTKSSYAVVHRFMLSHVG----------HKRSSSPCSG------SGTPHSEGGG-TSRSLSQTSL--- ------------------------HRM------------LEE--TEQQ--------------MAQSSA---- -------------------------------------------------IEPE-------GSNMEV------ ---------------------------------------SD------------------------------- ----------------------------------TADAQLE-A-------------HKDLR-------IS-- ----PTIINFGKPIKTSSPVNI------------LDGFEL---------ESMSS----------VNARRSKA ---------------QNC-QSKPRLD-----------SESGSSLGR------------------------AS RERKLS------------------------GG---------RKSSIRKSTKHSGDS---------------- -----------------------------------------------------TPSK--------------- ------VCF----RDVNITDDSESG--EGDTGGMK--------------------------------LSTE- EEIHNRYLRSMPSP-DEAAALHSPP-KYERSL-S-TSS---------------CRPRIQ------------- ------------------------------------------------------------------------ ----------------------------------VIPPTS-------------------PPPMCT------- -------------FFSEYTSLADE---------------------------------------------LET VCMSRLSPPSSP------------HLEYPGR---VAPQLRRRHRSESA--------GISITISS----NPLR DAEEADYQLMEGLIQRRMHRDSENLAVSLEDLCSVRTELSEAEDGAT----------------------PLN LR---------RDSRAVG--------LRKRHS--TTSID--------------------------------- -----NNPSELLSV-P-ESVQL-PSLQTIAS-------SLHPSS---------------------PLCG-RG -----------TRLTSSQPGSPSARRSSLHDD--------------------LHIQWASSGALPATGGWLTP WSSP----------RPRTPPLV----------------------------RPETPAVH-------------- ----------------------------------------------ETT-SDSASYPREPQPFM-------- ------------------------------------------------------------------------ -------STLQVPVSV-------------------------IVSLGQ------------------------- >Hame11961347_TRPC/1-1316 ------------------------------------------------------------------------ --MPA------------------------------------------------------------------- ------------------------------------------------------------------------ --------IRGVE---------------------------------ADVEEIKL----------KDS----- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------F SSNNSKAN---------------------------------------------------------------- ----------------------------------------------AIARALKKKI----------S----- ------------------------------------------------LTR--------------------- ----------LTSRSSL-VVD--------------------------------------------------- ---------------------------------------------------------------KDKDE---- ------------------------------------------------------------------------ ------------------RDRERRPSRD------------------------------RY-P-----TFTIE DWEEGEH------NGAFREDLAYKDDS--------------RADEKSEFEV---------------DTDLGE DGEAE---------------------------------------------------------GVSLV----- ---DNEDIRSV------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------TSS---------------- ------------------------------------------------------------------------ ---------------------KRTSQLSV------------------------------------------- -----------------------------------------DRS---------------------------- --------MVKCGR----AKFFKRLSVCDLK---SPSD---------------------------------- DEISW----QELREEDGEEGTPDPDAPPPQPRTRHLSILS-----------------------------QD- ---------GHMMDPK--ER---------------------------------------------------- -------------------------------------VF--LEAAERGDKHTMMRCL----SPPS------- -----------------------------------------------AVNVNCTDI-----------L-GRS AIQIAV------------------------------------------------------------------ --DNENV------EIVELLLLQ------------------------------------ENV----------- -----------------------------KI-G-----------------DALLYAIT-------------- ---------EGVYKIV--------EMLINH------------------------------------------ ------------PS---------------------------------------------------------- -----------ITP--EMLAN-----------------DWAKVR---------------------------- ------AG---------GE-ESSDFDPNI------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------SPI--------------------------ILAAHC----N------------------------Q FEILQ--------------------------------LFLSR-G--AYIDKPHPL----------------- ------------------------------------------SC------CCRQCTEG-FHDDS-LRYSMRR ---------------------------------------------IHTYRALAS------------------ ------------------------------------------------------------------------ PAWISLTSE----------------------------------------------------------DPV-- ------------------------------------------------------------------------ ---LAAFRLSWELERLAR------------------------------------------------------ -----------------------VENEFKDTYL--ELSEQCKKYTCDLLHQCRSTQE--------------- VIAVLNRRSE-------------------------------------EDSD--------------------- DDDDDDDP-Q---------------------------------------QQLKLSRLKLALKYD-Q-----K QFVAHPNCQ-----------QLLTSV--------------------------------------WH------ ----------------EGLPIWRRRNALVKILLCLS--IIVCMPVIAI--IYLIFP---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------RTSLG--------RVIRSPFMKFIYHSASFGLFLVLLVLAS--------------TR TEGSER------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------HRR----------------------------------------------------- ------NLRGPAPTFVEWLIFFWVTGMVW---------AECK-QL--WEE---------------------- GLTAYI-R----------QWWNWLDFIM-------------------LSLYLCTFSLRAVAFIQITTNKYG- ---------PREVP-----------------RS-------------QWPANDPTLIAEGVF----AVANVFS FARIIYLFQ----------------------------------------------TNPHLGP--LQISLGCM II-DIAKFLFIFFLVLTSF--ACGLNQLYWYY-DPPSTTYTAAD---------------------------- -GDTS------------------------------------C----HTGSD-A------------------- --------------------------------------------FNT-------------------DGGEY- -------------------------------------------------KGGFKTLDV--------T----- ---------------------FATLFWSLFGISS--PKSTD------------------------------- ---------------LEEE--------------------HGFI--ETVGQ----GLFMAYHVMSIIVLINML IAMMSNSFQQIEDHADQEWKFARSKLW------------------------MSYFDP--------------- --GSTLP-------AP--------------------FNLIISPKAIFYFMRTVKNCLQYI-----------C YRRS----------------RKRSDKR--R-SFAMEKGALQ-GGL-------PCRMSQSSRYAEVMRRLVS- --------------------------RYIHQTKKQ------------------------------------- ------------HRQDGVNEDD-LLEIKQDISSLRYELREDR------------------------KRETAR AYGQMDS----------------------------IKKDILR---------LLKQSGRMSSRSGN------- ------------------------GRE------------SE----G----------------AVGGVSA--- --NPV-------------------------------------------------------VLATVAAPCPAC AHIPA--------------------------AVGLTNTSHPSLGTP---------------GIIQQHSVDL- -------------------------------GMLGRDPSS-----------------GAVD----------- ---------------------------------------------------------------ITVTPASSL -------PCNL---------TYSQASMGLPSPQ----SLLPAGNLTG--------------------CLLAP QEMDYLRKEIV-SS---------------------------LRSELRELLREA------------------- ------------------------------------------------------------------------ -----------LARALTPTTTMAPQ---YYSPT--------------------------------------- ---------TTPNP--------TPQ-YATT---P-TAQTAQMAAPQ------FPLPP--------------- ------------------------------------------------------------------------ -----------------------------------VA----------------------------------- --------------------------------------------------------------------QQKQ CGQC----PPASGP--------QYSPPSP-----TSQPPQHPHLRVTTSLS--------DPVSQRSSSGPQT SPRSSP------------------------------------------------------------------ --------------------------VPQSSP--GSSP--------------------------IPP----- ---------------PCQRSNS-S----------------------------------------------CG L----------IQRSQGSSQSGGSSKSSTNQ----------------------------------------- --------------------------------------------------------VL-------------- ----------------------------------------------LRPPNES------------------- ----------------------------------------------------DRV----------------- --------------------------------------------------HTHM----YTQL---------- >Hame1437943_TRPA1/1-1238 ------------------------------------------------------------------------ --MSELRSVV-------------------------------------------------------------- ---------------------------------------------------------------------NML MKKKR-----------------------------------------ET------------------------ ----------------------------SKRW-RRAARVVT-SVYRCVGHKGDN------------------ ----------------------------------------------FY-----FVRDTGMSVP--------- ----------------------------------------------------------------GSRKESLV DDSLFQGVT-----DFITKNQ-------------------------ENGRT--------------------- ------------------------------------------------------------------------ ------LTSYDLI-------------------SRTLHQLARDGNSEVLSSALARL----------------- -------------------------GEHGRRRIN-----------NL-DGDKLSP----------------- --------LHYAAR---------YAHADTVKTLIHAGA---------------------------------- ----NVNIRGED---------------------------------------------------KLTPLHFAA RYRKQIKPNRRHSPVPPPPKDDDDT---E----TEEVENSKGE-ENPDLTITSNESE------RAIGIGSIP EN--SVIRILVECG----ADVNARDIYDQIP-LHYAAMRG-----------------NDP-A--------AR DLLKCPH--I--------------------------------QYEARDKQL--------------------- --------------------------------------------MTPLFVSATFGYVDISRRLILA-GSSL- ---FSKDE---------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------SE----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------Q----------------------------------------------------------- IPLHR---------------------ASMEG-----HMEIIELLLT--------------------SA-STE GGE-VVKRLVSERDS---EGQTSL---------HHAVNNGHIQVAA-------------------------- -----------RLLDAGADVDAVRDTL--------ATPL--HAAAAVGDTDLINLLLE-------------- ------NHAR-----LDSVDCNQ-----------------------------------------------QT PLHRAADHNQ-------------------------------------------------------------- ------S------AAIITLLE-----------------------------AGA------KI----------- -----------------------------ER-R-----DKDSF-------TPLLVAAS-------------- ---------AGHAAAV--------QTLLDH-DAD-VEAFDKDDKTAVFWCAEQGNEEALEVLLN-------- ----------------------------------------NIHCQELVD----------------------- ----VSDRYDNSPL--------HEAAK---------HGYMIIIN---------------------------- ------KLL---------EAGSLVDNKNEDGETA-------------------------------------- ------------------------------------------------------------------------ --------------------------------LHVAAEAGHVKVVRELIHR-------------YK--FLLS DENEESNTPL--------------------------HLACLQ----G------------------------H TDVVR--------------------------------TLLEA-G--AAVD-ATNS-------SLW------- --------------------------------------TPLDCAS------------AKGHVMC-VHLLLDY DSP------------------------------------------LDPLDK-T------------------- --------------------------KTT------------------------------------------- --------------------------------------------------------------------PLQL AAK------------------NGHV---------AVIRLLLERGASLTA-CDT------------------- -SGRNALELA---IAAG---------------------------------------KKDVCMAIIKSSEWET SL-----RNVRIDHRDRRI------TPFRMLIK--KF----PDVAEAVLDKCTTTNGM--------DSDDRR FAVSFNFEL------------VDDTYT-TYQYGNDI-DSLASNSTLESP----------FDEDGFLLDHAEP YTTEARE----------------------------------------LKENHPLML---MVKYK-R-----L NLLAHPVSI-----------SLVKHK--------------------------------------WM------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------K------------------- ---------------YGRFV-----------------YYSVLIFYMVFLTFLTGYI-------------LTA R-------------------------------------------------DWAS------------------ ------------V--EKKLN---------------------------------------------------- ------------------------------------------------------NSLM-------------- VQS-AKEQHSCEALKDE-VDLTDSV----------------------------------------------- -----------FVVAGKWVIIVMAVINIM---------REMF-QF--YQ----------------------- ARLNYIGL----------E--NLMEWCC----------------------YITAVVLVWDFND--------- -----------------------------------------CSIRQNWQW--------QVG----AASIFLG WMNLLLFIR----------------------------------------------KFPFLGI--FVVMFTDI FA-TFLKFFTVFLLFIVAF--ALAFYTVL----------------------RN------------------- --QEP-------------------------------------------FST-P------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------GHA----- ---------------------LLKTTVMMIGEFE--YDTIF------------------------------- -------NE-EN---L------------------------IY---PEVTY----TLFVVFLILMSILIMNLL VGLAVDDIKAVQDQAILKRLAMQTQMV------------------------LDVEVLI-------------- ------P------------------------------------ETLR----------RIQVV---------- --AK-----------------------------------------------------------KEV------ --------------------------HPNAR----------------------------------------- ------------------HGLF-SRLFGD------F------------------------------------ ------------------------------------------------------------------------ -------------------------------------QLIKT--FDF------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------VLDDE----------------------------------- -----------------------------------------------------------------QMNEQ-- ---------------------EAMRR-----------------DM--------------------THLITTV ------------------------------------------E-DLQSQNQR-------------------- ------------------------------------------------------------------------ ------------LRALLIA----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------LINI------------------------------------------------ --------------------------------------------------------------------SNNG SKG--------------------------------------------------------------------- ----------------------------NSDP--DVSKYV-------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Hame1447760_TRPApw/1-963 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------------MA-T- ------------------------------------------------------------------------ -----KKTLFRNIS----VE---------------G-STP-----------------GT------------- ------------------------------------------------------------------------ --------------------------------------------------------------------PMS- ---RGPKPD--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------ARF--------------------------------------------------------- NALLK---------------------ALKTQ-----ELQGVREQLS--------------------RG-LP- ---------VNYRE-P-ALGN--------------------------------------------------- -----------------------------------KTPL--ICASERGFLEAVVELLG-------------- --------------------------------------------AGA--NVSIADA-----------A-GAT PLHM----------------------------------------------------------------A--- -AGGGHL------STARLLLA-----------------------------HGA------HV----------- -----------------------------DP-L-----DAHAS-------TPLHYA---------------- -----------------------------A-RTD-IQD---------------------------------- -----------------------------------------PGSSSVI------------------------ ----------------------------------------GVVE---------------------------- ------ILL---------AAGARCGLRD-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---GEGRLPL--------------------------HNAATA----G------------------------S AKLIK--------------------------------VLAAG-PYKATIN-LKDN-------EGR------- --------------------------------------TPLHCAV-----------LGARSLDA-VAAVLKL GCS------------------------------------------IDARDS-Q------------------- --------------------------GHT------------------------------------------- --------------------------------------------------------------------ALHL AAKRQY-------------NHVDDEFD------GLCLELLLSHGASVAA-KNDEGYNALSLAVLRTMWWGRP GARDHILDAVQQLVAKG------------------------------------------------------- ----------------------SCIQDGFAMWR--MVE-SFPSLVPVALNRSICANTSAHDSPH-------- --LRLDFDFH----------PLSVNAK-----------------------------------HLREIHRQSP LNP--QS-----------------------------------ELPPPLLGDSEVTMFHYILWAGRK-----R LLL-HPLYK-----------SFLHLK--------------------------------------WS------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------K------------------- ----------------VRNY-----------------FLANVIFYFFFVLSLTAFL-------------LSS R-------------------------------------------------NCPDN----------------- -ATHD-N----DTMSAPTIT-------N---YS---IP---------------------------------- ------------------------------------------------------------------------ ------ASRNMTSVCRWAG--------------------------EEA----GVVG---------------- --------------LTWWCLVIFSAFLDL---------REVV-QL--MQ----------------------- NPLIYL-C----------NIGNLLDA-T----------------------LVFSVPQLLVGGS--------- -------PEEETTN-----------------G-----QMAMCCLA-VWQQ--------RVG----AIAIILA WVRLMLFTG----------------------------------------------QFPSCGV--YIVMFSTV AK-NVLKFLAMYMFVLVAF--ALGFYVLL----------------------RS------------------- --LPT-------------------------------------------FRT-P------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------GTA----- ---------------------LITSLVMMTGELD--YESTFLT----------------------------- ----------EPSESS------------------------------MLCI----FLLVVFIVLVYIILSNLL VGLAVSDMYAIQHRSEILRLTQHVELM------------------------IQVETLF------RNRL---- -----VP------------------------------------QKMQ----------RC------------- -----LLNSIAI-----------------------MGSQQKLTVSV----YPNRTRGFGE--GLFL------ --------------------------FLSKVIGTR------RLLIKLFEMFVSGFIPP-------------- ------------EYEVSLPSQL-MREALDVALRE-HEL-------------------------DKRE-RLLH LRALQ----------------------------------------------IGTTGHHKQNQSGQVAHVPIN QTTLTRGS-----------------SY----------RRPTT--TAV------------------RSSWRWT ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------LMSDTD--------------------SEDDT---------- ---------------------------------------------------------------VNML----H AQPSVWAPHPAASQRTVIPDPNARLE-----------------EL--------------------------- ------------------------------------------RNMVLSLQS--------------------- ------------------------------------------------------------------------ -----------TIESLTVV----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------IQQR DT---------------------------------------------------------------------- ---------------------------DQQLS--S------------------------------------- ------------------QIINSL------------------------------------------------ -------------DTEFTV----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Hame1602876_TRPA5/1-772 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------MDPSK------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------TDAEDWRVDIE-M-------------- ---------------------------------------------MERDELGGTGDG--------------- ------GGLSDGGGPNG------------------VGGP--------------------------------- --NDGGGLSDGG---------------------------------------------------GPNGVG-GP ------------------------------------------------------------------------ -------------------------------------NDGG----------------GLS-D---G------ ------------------------------------------------------------------------ -------------------------------------------------------------------GGSN- ---DGGGPN--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------DGL--------------------------------------------------------- LPLLR---------------------AIKHH-----DLNQVREEL--------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------LQ-------------- ---------RGELEAR--------NLVC-------------GNPKFLHTAASVLDLDIINLLLS-------- -------------------------------------------LGAQVT----------------------- ----AEDKEGNTVL--------HRAIAARPCDITAQDTIREILE---------------------------- ------IFL---------AAGADVNSTN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---QKEESPL--------------------------YLAAHF----Q------------------------L PNIVN--------------------------------FLLSE-K--ANPT-KVTK-------AGD------- --------------------------------------TVVHAAC------------NPGCATC-LKYLLNT GRVR---------------------------------------HLVTQPNH-K------------------- --------------------------DVQ------------------------------------------- --------------------------------------------------------------------PFMY ALQ------------------SCSA---------KCCEILLNNGNHLTR-THW------------------- -NNISSCSYL-------------------------------------------------------------- -------------------------------IQ--YLP-TATELLTRVFDANIRESNQ---------QKDNK LRIIFNYSV--------------------------------------------------------------- ILPQTEGG-----------------RRPAQNLLQ-------------KATTIQSSIISDINNTE------AE CLLKHPLME-----------TFIYLK--------------------------------------WG------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------K------------------- ----------------VKHI-----------------FHGELFIFALFLLCHTVYV-------------A-- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----SVYGETTRMMSD-LT----------------------------------------------------- -----------THPLFRGFHAFLYCLTLI---------PELI-IV--IS----------------------- HFKSYF-K----------YMETLLTATS----------------------VICSGYIVFRNIT--------- -----ITGASLVSS--LSTTASGNEEKNGE-NE-----------QLSVER--------TVA----AISIFTS WVRMMMLCG----------------------------------------------RLGFFGS--NVLMFSRV AK-SAVKFIAGFSGLLIGF--STSFFILF----------------------PE------------------- --ETE-------------------------------------------FNT-F------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------WKS----- ---------------------LAKTLTMMIGEID--YSSLVKK----------------------------- ---------------------------------------NT----PYIVY----IFLVLFIFLVCVLMANLL IGLAVDDIANLRRNGEVEKLSRQATFI------------------------VTFENFAVFARNSRFF----- ------P------------------------------------RRLAT---------YFIEL---------- --PK-----------------------------------------------------VKD--EKSF------ --------------------------KINEIKSK--KSFL-------------------------------- -------------CRYDLPRET-VEKAQ---------------------------------SIAKSN----- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------QT---------------------------------- ------------------------------------------------------------------LKHE-- ----------------ELTMTPRTILN----------------EI--------------------KKL---- ------------------------------------------RKQLE------------------------- ---------------------------NFSTL---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------LQFQ NQN--------------------------------------------------------------------- ---------------------------QK------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Hame163099_TRPA5-1/1-1159 ------------------------------------------------------------------------ --MKKLMK---------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------ILPFF------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------INRKSTVEECS-F-------------- ---------------------------------------------RDSDQTSFQLNG--------------- ------GNYQSGGRQAG----ESTGRFSVLDV---------------------------------------- -----TVITDDA---------------------------------------------------AASLVS--- ------------------------------------------------------------------------ ----------------------------------------------------------------LP------ ------------------------------------------------------------------------ -------------------------------------------------------------------ASQL- ---DEHDSW--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------EFI--------------------------------------------------------- PPLFV---------------------AIKTG-----DVRGLRDILAVDP-----------------KA-AS- ------------------RPK------------------------------------YGG------------ -----------------------------------FPPL--HAACNVKNLHILRELLT-------------- --------------------------------------------NDA--KVGALGG-----------L-GHT ALHLAVSEGW-------------------------------------------------------------- ------H------EGVAELLQ-----------------------------HGA------SPDAMLE------ -----------------------------PP-S-----TVKGM----HVETSLHSAVR-------------- ---------RGDLTST--------VLMLER-QPD-LTLTDSNNCTVLHLAAQARSPEIIHQLLQK------- -----------------------------------------KLPNEVVT----------------------- ----VCDRDNNSVL--------HKALL-RNCDAAEESKVCSIVE---------------------------- ------ELV---------KAGAKVNSIN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---NQGESPL--------------------------FLAAQQ----R------------------------L PKLVE--------------------------------LLLSL-E--ADPT-IVTR-------RGQ------- --------------------------------------SVLHAAC------------KHGCTSC-LGYLLAT NLVK---------------------------------------HLVTEPDN-E------------------- --------------------------GRE------------------------------------------- --------------------------------------------------------------------PFHY AVH------------------SGSI---------DCCELLLNNGDHLTR-LDK------------------- -DGVSRCSLI-------------------------------------------------------------- -------------------------------LE--HLP-SALQLLRRLFDAHVLLSNN--------PQHDAD FRVTFDYSV--------------------------------------------------------------- LSSEKEG--------------------------------------------IQSSLTSELSNSR------LE ALLKHPLLE-----------SFLFIK--------------------------------------WR------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------K------------------- ----------------IKPL-----------------FYCSVLIYLMFLLVHTTFI-------------V-- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----MTYGANSWNWHDKRD----------------------------------------------------- -----------LLTIFILIHVVMFLLILI---------PDLI-IM--FA----------------------- NFKKYL-R----------QWETLTKSIA----------------------LGSSAIVVFSNII--FLDNKTS E-----TTNVMADNVISNI-TAGNFSQNSNVSELGTGNYNRSRVEMPLVQ--------SAA----AISGFFC WVEFMMLLG----------------------------------------------RFPSLGT--YVLMFSRV AR-SIIKFIAAFSSLIIGF--AISFMVLF----------------------HN------------------- --QKP-------------------------------------------FKS-F------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------PLS----- ---------------------LVKTLMMMIGEID--YNSLMSE----------------------------- ---------------------------------------LEE---RVLSC----IFLVSFLFLVCVLMANLL IGLAVNDIPDLQRQGKIKRLSKQASYL------------------------VSYEKLMIIARNMSCF----- ------P------------------------------------RQLRI---------LMSSR---------- --CR-----------------------------------------------------IPQ--RVNV------ --------------------------LPNKHHSS--TRKS-------------------------------- -------------LEHNVPSET-LQEAIL-LGNC---------------------------EDSNDDLNNIE EEDLM----------------------------GQFKS---------------------------------- ------------------------FKLKYARDRRALNRRLAQ--LPD------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------STATEK---------------------------------- ------------------------------------------------------------------MLKE-- ----------------SMDQMQQIVQN----------------QL--------------------TQL---- ------------------------------------------SLQLQQYNHNC---------------THCH PLPSTQKQRQRNRQPQEVEYYPPYSQNQWPTLSVLQQSVQTQSVPLQTVKTQSVPQQTLQTQSMPQQILQTQ SVPQHTLQTQSVPQQILQTQSVPQQ----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------TLQTQSV---------------------------------------------- --------PQQTV-----------QTQSVPQQTVQTQSVPQQTLQTQSVPQ-----QTLQTQSVPQQTVQTQ SVP--------------------------------------------------------------------- ---------------------------QQTVQ--TQLMPRHCVLQQSVQKQQESY-IQQPQHPLEQS-QYTQ ---------------H-QTTHQPL------------------------------------------------ -------------SQQQQLTHQYL------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------SQQQ------------ ------------------------------------------------------------------------ -----------------------------------------PMTREYVQQ---------------------- >Hame1715279_Iav/1-1091 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------MYNH---------------------GRG-K-----EITRT EYLKWKYRKV------------------------------------PKDQMVVQM----------------- --------------------------------------------------------------------ETK- ---SPFDPL--------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------HK----------------- --------------------------------------------WSD------------------------- -------------------------------------------------------------HE--------- ----------------------------------------ACWQ---------------------------- ---------MQFRGSLG-------------------E----------------------------------- TLLHV-------------------------------------LIMC-------------------------- ------------------------------------------------------------------------ -----------------------------------DTKA--HTR-------VAKILLR-------------- ---CF---------------------------------------PKLGIDVVEGEEYL-----------GAG ALHLAI------------------------------------------------------------------ --AYSN------NELVTILMA-----------------------------CGV------SFTQRAIGSFFLP RDQQVTQPP-----------------GPEY--T-----DYEGLAY--LGEYPLAWSAC-------------- ---------LGNETVY--------NKLLDL-GAD-------------------------------------- ------------PN---------------------------------------------------------- ----LQDSFGNMIL--------HMVVV---------CNQLGMFS---------------------------- ------YALR------HPRLPAQDGIMN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---LAGLTPL--------------------------TLACKL----A------------------------R STIFK--------------------------------EMLEL---------TCIE-------FWRY------ --------------------------------------SNITCSA--------------------------- -------------------------------------------YPLNALDTIRP------------------ -------------------------SGET------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -NWNSALMII-------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ LNGTKSE----------------------------------------------------------H-----L DMLEGGIIQ-----------RLLEEK--------------------------------------WK------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------T------------------- ---------------FARNQ-----------------FLKRLAIMLLQLVLLSGAV-------------YLR PCYCCP----------------------------------------------K------------------- -NMWK----------------------N---STEYS------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------VLLYD--------NFYDAD-- -----------FMSI---ARYCFETGTLA---------GVIS-YV-VFQQ--------GEE-------IMNQ GLSSFM-R----------GLSGNAPKAI----------------------FLLSNLLIMLCVPCRVVYFFK- -------------------------PKMYFLRD--------------IED--------ELM----AYAVAGS WFMLMFFAG----------------------------------------------ALKLTGP-FVVMIYKMI TG-DMFTFSIIYFIMLLGF--SEAFFFLY----------------------KSP------------------ KHDKD-----------------------------------------SKYAT-Y------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------GTT----- ---------------------WMALFHMTLGDYD--YAGMNQN----------------------------- ----------------------------------------IY---SSMSK----FVFLVFTIMLPIMLLNML IAMMGNTYSTVISMSEKEWVKAWAKIV------------------------IALERAISQEKAKDYLY---- --MYSLPLGGGGD------------------------GVEESLGVMVI---------KSKDK---------- -TKA----------------KQRKGA----------LSNWKRV------------------GRVTIDALQRR GVSGEFLRREMWGLQTAAS-------TPVKGPAKKKGYGGL----------LGIETGPATSDIMGDALNQSI FAGGE--IIDPNDEMDGFG-AL-TGAIDQ-LAFT-NDLDF--------------------------SGDGID DDPLKP----------------------------NLGHDQKP------------------------------ ------------PVYSTTLQVPAEPKK---KKK-KRRNSSDG--YDNPAFID-------DEELLLASALD-- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------GGESDGS-----------------DTDMLE---------- ---------------------------------------------------------------SRRLAKP-- --------------RIIIR--AETEV----------------ATVS-------------------TTTTTST KPTATTAGKTP--------------------------GTAVAAKDPKAAVQTAAT---------NVPV---- ------------------------------IIPRQRL----------------------------------- --------PSAKMRRIGSAR---------KTPARFA------------------------------------ MTFTEKY--DPVGK------------EVQKKVVK-PEDTAGAVSV-----TERAEE---------------- -------------------------------ETKKK-DDKKKGKK--------------------------- ---------------SEE--EATTSTMDV------------------------------------------- -------------------QEED------------------------------------------------- -----------------------------------GDSGD-KWAEKK-------------------PRRHKN KVG------------------------------------PSNS----------------------------- ---------------------------SEECV--IGVEAQTQD-DMSIGL--------------HSG-TDST ---------------R-EEVKA-------------------------------------------------- -------------KDKERPKTSVASQ---------------------------------------------- ----------------------------------------------------KMKKR--------------- --------------------------------------------------ATENVGNMNS------------ ------------------------------------------------------------------------ ----------ILPWDNEDGDIK-------------------------------------------------- >Hame188972_TRPA1-like1/1-1140 ------------------------------------------------------------------------ --MPQST----------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------KPGCQ------ ----------------------------------------------QASPLP----------YIY------- -----VPMD-----TTDAKPNSGRK-----------------------------------------TL---- RESVSQK----------------------------------------------------------------- ----------------------------------------------DFH-LCQKL----------------- -------------------------LNEG-ESVT-----------Y-KDEDGSSL----------------- --------LHILAKKY---SKRETRAQNIPSLLLQYGA---------------------------------- ----EINVKDKN---------------------------------------------------GDAPLHI-- ------------------------------------------------------------------------ -----------------------------------A-ARE-----------------GLK-D--------LC IILVEHQK-VN--STN-------------------------PKVNIKNKKS--------------------- --------------------------------------------MTPLHYAAYQGELQIVKLLIKE-GADP- ---CARDH---------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------MRY--------------------------------------------------------- LPLHH---------------------AADRG-----HHECCKELAPF------------------------- ---------YVGDTV---QGQ--------------------------------------------------- -------------------------EI--------SPPV--MLAAMKGHYRCFKEMVH-------------- ---V---------------------------------------HAKM--NLNFRNA-----------A-GNT PLHMVARSGF-------------------------------------------------------------- ------E------KFAALLIE-----------------------------TGA------AL----------- -----------------------------DI-Q-----NNVGN-------TPLMEAVL-------------- ---------RNKISCL--------SVLMEK-EAN-VNIKNNSQSGVLHVAATKKAEECMEYLLKH------- -----------------------------------------EEVKKELN----------------------- ----EKDKDGYTAL--------FIAVR---------KHSEKCAV---------------------------- ------LLL---------AAGASTSIVCQQKLSL-------------------------------------- ------------------------------------------------------------------------ --------------------------------LHLAADNVRPTLLEKLLMI---------RT------LDVN VKNIDNETPL--------------------------HVVARG----G------------------------S REGCQ--------------------------------LLLRK-G--AHID-AADK-------NGR------- --------------------------------------TALQLSA------------YQGHSSV-VRLLIKY GAN------------------------------------------KRAKDD-N------------------- --------------------------NTT------------------------------------------- --------------------------------------------------------------------ALHA AAA------------------KGNL---------ECCEILSDADKALYKLQDR------------------- -KKRYALDIA---FLKGHDKVFQFLLNILPYKNINTMPQDLQDHLHSYTHKALKGRKKTVVETIVRSQWWEA GFGV----------VKKHE--DVPCTNFRELIK--LY----PFLAQVVMDHCTSV-----------TEKCT- ---LYDFRL------------LEDNYC-IKEDKNI----LRSSVKSPFNQQ-----------TWEVLPAAKE LTSKVLV----------------------------------------WKKEHPVSI---MAHHR-C-----L GLLQHPLTE-----------AWISFK--------------------------------------WK------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------S------------------- ---------------YARWI-----------------FAGLLVLRLFAVGVLIGFM-------------ATI H-------------------------------------------------NWE------------------- --------------QVKKYS-------N---KS------------------KEVFCGV-------------- ---------------------------------------------------LETSHDT-------------- VN--AAEEMMTPEFTGR--------------L---------QWNST-------------------------- -----------VYYTWHVLLLVSLILQVT---------LEVM-ST--KK----------------------- LQWDYV-------------------------DSTFIFVRIPS--------LVLTTIVCIPSCK--------- -------------------------------------CGFQLGIKMVPIW--------QCG----ILALLMA WVQLIQIIN----------------------------------------------KLPQLSI--FTISTWDF IK-CYLKGLMYIGMVIILF--AFIFFMLL----------------------RD------------------- --QLA-------------------------------------------FKT-V------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------PQS----- ---------------------IIKTVVWMLGDLN--YDETFVG-ENK------------------------- ---------------L------------------------SY---PVLVN----VLFLIFMCTVWVFIVTLI KTPSSDE-----REVALYRKAGRANLI------------------------LNLDVLF-------------- ------P--------------------------------------SL----------RRKYA---------- --IG-----------------------------------------------------------KYN------ --------------------------NMYKR----------------------------------------- ------------------P-WL-VKKIQN------FQRPSS---------------------WMSRT----- -------------------------------LALSFNM-----------VA-LMDLDELKKDDNNDQVLSKF ----EEFF-----------------QL---FKKKVDGTANLS--LPD------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------PQQDH----------------------------------- ------------------------------------------------------------------LEAQ-- ---------------------TRKLD-----------------QL--------------------LTLFNQL ------------------------------------------NDNYQKQNEQ-------------------- ------------------------------------------------------------------------ ------------MIELKQQ----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------LD-------------------------------------------------- ----------------------------------------------------------------------NM KQK--------------------------------------------------------------------- ---------------------------SRHS----------------------------------------- ---------------------VHI------------------------------------------------ -------------P---------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >MOUSE_TRPA1/1-1125 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --MKR------------------------------------------------------------------- -----------------------------------GLRRIL------------------------------- -------------------------------------------------------------LP--------- -----------------------------------------------------------------EERKEVQ GVVYR-----------------------------------------GVGED--------------------- ----------------------MDC----------------------------------------------- ------SKESFKV---------------------------------DIEGDMCRLE-D-------------- -------------------------FIKNRRKLS-----------KY-EDENLCP----------------- --------LHHAAA---------EGQVELMELIINGSSC--------------------------------- ---EVLNIMDGY---------------------------------------------------GNTPLHCAA ------------------------------------------EKNQVE------------------------ -----SVKFLLSQG----ANPNLRNRNMMSP-LHIA-VHG-----------------MYN-E--------VI KVLTEHKA-T--------------------------------NINLEGENG--------------------- --------------------------------------------NTALMSTCAKDNSEALQILLEK-GAKL- ---C--KS---------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------NK----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------WGD--------------------------------------------------------- YPVHQ---------------------AAFSG-----AKKCMELILA--------------------YG-EKN GY--SRETHINFVNH---KKASPL---------HLAVQSGDLDMIK-------------------------- -----------MCLDNGAHIDMMENAK--------CMAL--HFAATQGATDIVKLMIS-------------- ------SYTGSSDI-VNAVDGNQ-----------------------------------------------ET LLHRASLFDH-------------------------------------------------------------- ------H------DLAEYLIS-----------------------------VGA------DI----------- -----------------------------NS-T-----DSEGR-------SPLILATA-------------- ---------SASWNIV--------NLLLCK-GAK-VDIKDHLGRNFLHLTVQQPY--GLRNLRP-------- ---------------------------------EFMQMQ---HIKELVM----------------------- ----DEDNDGCTPL--------HYACR---------QGVPVSVN---------------------------- ------NLL---------GFNVSIHSKSKDKKSP-------------------------------------- ------------------------------------------------------------------------ --------------------------------LHFAASYGRINTCQRLLQD-------------ISDTRLLN EGDLHGMTPL--------------------------HLAAKN----G------------------------H DKVVQ--------------------------------LLLKK-G--ALF--LSDH-------NGW------- --------------------------------------TALHHAS------------MGGYTQT-MKVILDT NLK-----------------------------------------CTDRLDE-E------------------- --------------------------GNT------------------------------------------- --------------------------------------------------------------------ALHF AAR------------------EGHA---------KAVAMLLSYNADILL--NK------------------- -KQASFLHIA---LHNK---------------------------------------RKEVVLTTIRNKRWDE C------LQVFTHNSPSNR------CPIMEMVE--YL----PECMKVLLDFCMIPSTE--------DKSCQD YHIEYNFKY------------LQCP--------------LSMTKKVA-PTQDVVY----------------- ---------------------------------------------------EPLTILNVMVQHN-R-----I ELLNHPVCR-----------EYLLMK--------------------------------------WC------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------A------------------- ---------------YGFRA-----------------HMMNLGSYCLGLIPMTLLV-------------VKI Q----------------------------------------------------------------------- ---------------PGMAF-------N-------------------------------------------- ------------------------------------------------------------------------ -ST-GIINGTSSTHEER-IDTLNSF----------------------------------------------- -----------PIKICMILVFLSSIFGYC---------KEVI-QI--FQ----------------------- QKRNYF-L----------DYNNALEWVI----------------------YTTSIIFVLPLFL--------- ------------------------------------------NIPAYMQW--------QCG----AIAIFFY WMNFLLYLQ----------------------------------------------RFENCGI--FIVMLEVI FK-TLLRSTGVFIFLLLAF--GLSFYVLL----------------------NF------------------- --QDA-------------------------------------------FST-P------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------LLS----- ---------------------LIQTFSMMLGDIN--YRDAFLEPLFR------------------------- -------NE------L------------------------AY---PVLTF----GQLIAFTMFVPIVLMNLL IGLAVGDIAEVQKHASLKRIAMQVELH------------------------TNLEKKL-------------- ------P------------------------------------LWYL----------RKVDQ---------- --RS-----------------------------------------------------------TIV------ --------------------------YPNRPRHG-------------------------------------- ----------------RMLRFF-HYFLNM------Q------------------------------------ ------------------------------------------------------------------------ ----------------------------------ETRQEVPN--IDT------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------CLEME----------------------------------- ------------------------------------------------------------------ILKQ-- ---------------------KYRLK-----------------DL--------------------TSL---- ---------------------------------------------LEKQHEL-------------------- ------------------------------------------------------------------------ ------------IKLIIQK----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------MEII------------------------------------------------ --------------------------------------------------------------------SETE DED--------------------------------------------------------------------- ---------------------------NHCSF--QDRFKKERL----------------------EQ-MH-S ---------------K-WNFVLNA------------------------------------------------ -------------VKTKTHCSISHPDF--------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >MmusTRPM1/1-1622 ------------------------------------------------------------------------ --MG-------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------SMRKMSSSFKRGSIK---------------------- ------------------------------------------------------------SSTSGSQK---- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----GQKA---------------------------------------------------------------- ----------------------------------------------WIEKTFCKRE----------CIF--- ---------------------------------------------VIPSTK-DPN----------------- --RCCCGQL-TNQHIPP-LPSGAPSTTGEDT-------------------------------------KQAD TQSGKWSVSKHT---------------------------------------------------QSYPTDSYG ILEFQGGGYS--------------------------------NKAMYIR----------------------- ------------------VSYDTKPDSLLHL-MVKD--------WQLELPKLLISVHGGL-Q-----SFEMQ PKLKQ---------------------------------VFGKGLIKAAMTT--------------------- -----------------------------------GAWIFTGGVSTGV---------------VSHVGDAL- ---KDHSSK--------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------SRG---------------- ------------------------------------------------------------------------ ----------------------RLCAIGI------------------------------------------- ----------------------------------------APWG---------------------------- --------MVENKEDL-------------IG-----KD---------------------------------- VTRVY----QTMS--------------NPLSKLSVLNNSHTHFILADNG-------------TLGKYG-AE- ---------VKLRRQL--EK-------------HISLQKINTRLGQ-------------------------- -----------------------------------GVPV--VGLVVEGGPNVVSIVLE--YLKEDP------ -----------------------------------------------PVPVVVCDG-----------S-GRA SDILSFAHKYCDEG-------GVINESLRDQLLVTIQKTFNYSKSQSYQ-------------LFAIIME--- --CMKKK------ELVTVFRMG---------------------------SEGQ-----QDV----------- -----------------------------EM-A-I--------------LTALLKGTN-------------- ---------ASAPD----------QLSL-------------------------------------------- ------------------------------------------------------------------------ ------------AL------------------------AWNRVD---------------------------- ------IA------------RSQIFVFGPHWPPLGSLAP--------------------------------- ------------------------------------------------------PVDTKATEK--------- ------------EK-----------------KPPTATTKGRGKGKGKKKGKVKEEVEEETDPRKLEL----- ---LNWVNAL----------------------EQAMLDALVL----D------------------------R VDFVK--------------------------------LLIEN-G--VNMQHFLTI--------PRL------ --------------------------------------EELYNT-------------RLGPPNT-LHLLVRD --------------------VKKSNLPPDYHISLIDIGLVLEYLMGGAYRCNYT-----------RKSFRTL YNNLFGPKR--------------------------------------------------------------- PKALKLLG---MED-------DEPPAKG-------------KKKKKKKKEEEIDIDVDDPAVSRFQ-YPFHE LMVWAV--------------LMKRQ---------KMAVFLWQRGEECMA----------------------- -KALVACKLYKAMAHESSES---------------------------------------------------- ----------------------ELVDDISQDLD--NNSKDFGQLAVELLDQSYKHDEQ-------------V AMKLLTYELK-------------------------------------------------------------- -------------------------------------------------NWSNSTCLKLAVAAK-H-----R DFIAHTCSQ-----------MLLTDM--------------------------------------WM------ ----------------GRLR--MRKNPGLKVI------MGILIPPTIL--FLEFR----------------- -TYDDFSYQT----------------------------------SKENED---------------------- -----GKEK-----------------------------EEENVDANADAG---------SRKGD-------- ---------------------------------------------------------------EENEHKKQR SIPIG-----------TKIC--------EFYNAPIVKFWFYTISYLGYLLLFNYVI-------------LVR MDG--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------WPSPQEWIVISYIVSLAL---------EKIR-EI--LMS----EPG-----------KLSQ KIKVWL-Q----------EYWNITDLVA-------------------ISMFMVGAILRLQ------------ -------------------------------------------------SQPYMGYGRVIY----CVDIILW YIRVLDIFG----------------------------------------------VNKYLGP--YVMMIGKM MI-DMLYFVVIMLVVLMSF--GVARQAILHPE-------------------EK------------------- -------------------------------------------PSWKLARN--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------I----- ---------------------FYMPYWMIYGEVF--ADQID------LYAMEI--NPPCGENLYDEE----- ----GK---RLPP-CIPGA---------------------------WLTP----ALMACYLLVANILLVNLL IAVFNNTFFEVKSISNQVWKFQRYQLI------------------------MTFHDR--------------- ---PVLP-------PP--------------------MIILSHIYIIIM----------RLSG-------RCR K-KR----------------EGDQ---------EERDRGLKLFLSD------EELKKLHEFEEQCVQEHFR- -------------------------EKEDEQQSSS------------------------------------- ------------DERIRVTSER-VENMSMRLEEINERENFMKT----------------SLQTVDLRLSQLE ELSGRMVSALENL-----------------------------------AGIDRSDLIQARSRASSEC-E--- --------------------------------------------------ATY---------LLRQSSI--- --NSADGYSLYRYHFNGEE------LL----------------------FEEP-------ALST-------- ---------------------------------------SPGTAFR-----------------KKTYSF--- ------------------------------------RVKD-----------------EDAK----------- ----------------------------------------------------------------SHLDQPS- ---------------NLH-HTPG--------------PSPPATPGR-------------------------S R-----------------------------LAL----EGP-LSTELRPGSDPGISAGEFD------------ -------------------------------------------PRADFKSTEAAPSL--------------- ------NAAGVTGTQLTVE-STDS-------------------------------------------HPLR- ESKLVRY-----YP----GDPNTYKTMKSRSF-V-YTE---------------GRKLVR------------- ------------------------------------------------------------------------ ----------------------------------GLSNWS-------------------------------- ---------------AEYSSIMDQAW-----------------------------------------NATEW RC-QVQRITRSR------------STDIPYI------------VSEAA------------------------ --------------------------------------SQDELEDEH------------------------- -----------RGSLLDP-------QISRSAL---TVSDR-------------------------------- ---------------P-EKENL-LSVKPHQT----------------------------------------- -----------LGFPCLRSRSLHGRPRS-------------------------------------------- ------------------------------------------------------------------------ ----------------------------------------------AEPAPSKLDRAGHAS----------- ------------------------------------------------------------------------ --------STSN--LA------------------------VMSVVPEGQ-NTQQEKRSAETEC--------- >MmusTRPM2/1-1506 ------------------------------------------------------------------------ --ME-------------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------SLDR----------------RRTGSEQEEGF------------------ ---------------------------------GVQSRRATDLGMVPNLRRS-------------------- -----------------------------------------------------------NSSLCKSRRFL-- -----------------------------------------------------------------------C SFSSE------------------------------------------------------------------- -KQENLSS---------------------------------------------------------------- ----------------------------------------------WIPENIKKKE----------CVY--- ---------------------------------------------FVESSKLSDA----------------G KVVCACGYT-HEQH-----LEVAIKPHTFQ------------------------------------------ --GKEWDPKKHV---------------------------------------------------QEMPTDAFG DIVFTDLSQK---------------------------------VGKYVR----------------------- ------------------VSQDTPSSVIYQL-MTQH--------WGLDVPNLLISVTGGA-K-----NFNMK LRLKS---------------------------------IFRRGLVKVAQTT--------------------- -----------------------------------GAWIITGGSHTGV---------------MKQVGEAV- ---RDFSLSSS------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------CKE---------------- ------------------------------------------------------------------------ ---------------------GEVITIGV------------------------------------------- ----------------------------------------ATWG---------------------------- --------TIHNREGL-------------IHPM---GG---------------------------------- FPAEY-----MLDE-------------EGQGNLTCLDSNHSHFILVDDG-------------THGQYG-VE- ---------IPLRTKL--EK-------------FISEQTKERGGVA-------------------------- ----------------------------------IKIPI--VCVVLEGGPGTLHTIYN--AINNG------- ------------------------------------------------TPCVIVEG-----------S-GRV ADVIAQVATLPVSEITI-SL-------IQQKLSIFFQEMFETFTENQIV-------------EWTKKIQ--- -DIVRRR------QLLTIFREG---------------------------KDGQ-----QDV----------- -----------------------------DV-A-I--------------LQALLKA---------------- ---------SRSQDHFG-HENWDHQLKL-------------------------------------------- ------------------------------------------------------------------------ ------------AV------------------------AWNRVD---------------------------- ------IA------------RSEIFTDEWQWK---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------PADL----------------------HPMMTAALIS----N------------------------K PEFVR--------------------------------LFLEN-G--VRLKEFVTW--------DTL------ --------------------------------------LCLYEN--------------LEPSCL-FHSKLQK --------------VLAEE-QRLAYASATPRLHMHHVAQVLRELLGDSTQLLY------------PRPRYTD RPRL-------------------------------------------------------------------- ----SMT------------------------------VPHIKLN-VQGVSLRSLYKRSTGHVT-FTIDPVRD LLIWAV--------------IQNHR---------ELAGIIWAQSQDCTA----------------------- -AALACSKILKELSKEEED----------------------------------------------------- -------------------------TDSSEEML--ALADEFEHRAIGVFTECYRKDEE-------------R AQKLLVRVSE-------------------------------------------------------------- -------------------------------------------------AWGKTTCLQLALEAK-D-----M KFVSHGGIQ-----------AFLTKV--------------------------------------WW------ ----------------GQL---CVDNGLWRII------LCMLAFPLLFTGFISFR----------------- --EKRLQ----------------------------------------------------------------- ------------------------------------------------------------------------ --------------------------------------------------------------------ALCR PAR-------------VR----------AFFNAPVVIFHMNILSYFAFLCLFAYVL-------------MVD FQP--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------SPSWCEYLIYLWLFSLVC---------EETR-QL--FYD---PDGC-----------GLMK MASLYF-S----------DFWNKLDVGA-------------------ILLFIVGLTCRLIP----------- ---------------------------------------------------ATLYPGRIIL----SLDFIMF CLRLMHIFT----------------------------------------------ISKTLGP--KIIIVKRM MK-DVFFFLFLLAVWVVSF--GVAKQAILIHNE------------------SR------------------- -------------------------------------------VDW-IFRG--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------V----- ---------------------VYHSYLTIFGQIP--TY-ID---GV-NFSM-----DQCSPNG--------- -------TDPYKPKCPESDW--------------TGQAPA-FP--EWLTV----TLLCLYLLFANILLLNLL IAMFNYTFQEVQEHTDQIWKFQRHDLI------------------------EEYHGR--------------- ---PPAP-------PP--------------------LILLSHLQLLIK----------RIVL-------KIP AKRH---------------------------------KQLKNKLEK------NEETALLSWELYLKENYLQ- -------------------------NQQYQQKQRP------------------------------------- ------------EQKIQDISEK-VDTMVDLLD------MDQVK----------------RSGSTEQRLASLE EQVTQVTRALHWI----------------------------------------------------------- ------------------------VTT------------LKD--------SGF---GSGAGALTLAPQ---- --------------------------------------------RAFDEPDAE-------LS---------- --------------------------------------------------------------IRRKVEEPGD G------------------------------YHVSARHLLYPN-------------ARIMR-------FP-- VPN--------------------------------------------------------------------- -------------------------------------EKVPWAAEFL-IYDPPFY---------------TA E-KDVA-----------------------------------LTDPVGDTAEP-------------------- -------------------------------L---------------------------------------- -------------SKISYN---------------------------------------------VVDGPTDR RSFHGVY-------------------VVEYGF-P-LNPMGRTGLR--------GRGSLS------------- ------------------------------------------------------------------------ ---------------------------------WFGPNHT-------------------LQPVVTR------ ------------WKRNQGGAICRKSVR----------------------------------------KMLEV LV---MKLPRSE---------------------------------HWALP------------------GGSR EPGEMLPRKLKRVLRQEF--------------------------------------WVAFET---------- -------------------------LLMQGTEVYKGYVD---------------------------D----- ---------------P-RNTDN-------------------------------------------AWIETVA ----------------------------------------------------VSIHFQDQN----------- -------------------------------------------DME----LKRLEENLH------------- ---------------------------------------------THDPKELTRDLKLSTEWQV-------- ------------------------------------------------------------------------ -------VDRRIPLYANHKTILQKV--------------ASLFGAHF------------------------- >MmusTRPM3/1-1721 ------------------------------------------------------------------------ --MGKKWRDA--------GELERGCSD--------------------------------------------- ------------------------------------------------------------------------ ----REDS---------------------------------------------------------------- ----------------------------------AESRRRSRSASRGRFAES-------------------- --W------------------------------------------------------KRLSSKQGSTKR--- ----------------------------------------------SG------------------------ -------LP--------------------------------------------------------------A QQTPAQKS---------------------------------------------------------------- ----------------------------------------------WIERAFYKRE----------CVH--- ---------------------------------------------IIPSTK-DPH----------------- --RCCCGRL-IGQHVGL-TPSISVLQNEKNESR----------------------------------LSRND IQSEKWSISKHT---------------------------------------------------QLSPTDAFG TIEFQGGGHS--------------------------------NKAMYVR----------------------- ------------------VSFDTKPDLLLHL-MTKE--------WQLELPKLLISVHGGL-Q-----NFELQ PKLKQ---------------------------------VFGKGLIKAAMTT--------------------- -----------------------------------GAWIFTGGVNTGV---------------IRHVGDAL- ---KDHASK--------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------SRG---------------- ------------------------------------------------------------------------ ----------------------KICTIGI------------------------------------------- ----------------------------------------APWG---------------------------- --------IVENQEDL-------------IG-----RD---------------------------------- VVRPY----QTMS--------------NPMSKLTVLNSMHSHFILADNG-------------TTGKYG-AE- ---------VKLRRQL--EK-------------HISLQKINTRIGQ-------------------------- -----------------------------------GVPV--VALIVEGGPNVISIVLE--YLRDTP------ -----------------------------------------------PVPVVVCDG-----------S-GRA SDILAFGHKYSEEG-------GLINESLRDQLLVTIQKTFTYTRTQAQH-------------LFIILME--- --CMKKK------ELITVFRMG---------------------------SEGH-----QDI----------- -----------------------------DL-A-I--------------LTALLKGAN-------------- ---------ASAPD----------QLSL-------------------------------------------- ------------------------------------------------------------------------ ------------AL------------------------AWNRVD---------------------------- ------IA------------RSQIFIYGQQWP---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------VGSL----------------------EQAMLDALVL----D------------------------R VDFVK--------------------------------LLIEN-G--VSMHRFLTI--------SRL------ --------------------------------------EELYNT-------------RHGPSNT-LYHLVRD --------------------VKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYT-----------RKRFRTL YHNLFGPKR--------------------------------------------------------------- PKALKLLG---MED-------DIPLRRG--------------RKTTKKREEEVDIDLDDPEINHFP-FPFHE LMVWAV--------------LMKRQ---------KMALFFWQHGEEAMA----------------------- -KALVACKLCKAMAHEASEN---------------------------------------------------- ----------------------DMVDDISQELN--HNSRDFGQLAVELLDQSYKQDEQ-------------L AMKLLTYELK-------------------------------------------------------------- -------------------------------------------------NWSNATCLQLAVAAK-H-----R DFIAHTCSQ-----------MLLTDM--------------------------------------WM------ ----------------GRLR--MRKNSGLKVI------LGILLPPSIL--SLEFK----------------- -NKDDMPYMTQAQEIHL--------------------------QEKEPEEPE-------------------- ---KPTKEK-----------------------------DEEDMELTAMLGRSNG---ESSRKKD-------- ---------------------------------------------------------------EEEVQSRHR LIPVG-----------RKIY--------EFYNAPIVKFWFYTLAYIGYLMLFNYIV-------------LVK MER--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------WPSTQEWIVISYIFTLGI---------EKMR-EI--LMS----EPG-----------KLLQ KVKVWL-Q----------EYWNVTDLIA-------------------ILLFSVGMILRLQ------------ -------------------------------------------------DQPFRSDGRVIY----CVNIIYW YIRLLDIFG----------------------------------------------VNKYLGP--YVMMIGKM MI-DMMYFVIIMLVVLMSF--GVARQAILFPN-------------------EE------------------- -------------------------------------------PSWKLAKN--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------I----- ---------------------FYMPYWMIYGEVF--ADQIDRKQ---VYDSHTPKSAPCGQNETRED----- ----GK-TIQLPP-CKTGA---------------------------WIVP----AIMACYLLVANILLVNLL IAVFNNTFFEVKSISNQVWKFQRYQLI------------------------MTFHER--------------- ---PVLP-------PP--------------------LIIFSHMTMIFQ----------HVCC-------RWR --KH----------------ESDQ---------DERDYGLKLFITD------DELKKVHDFEEQCIEEYFR- -------------------------EKDDRFNSSN------------------------------------- ------------DERIRVTSER-VENMSMRLEEVNEREHSMKA----------------SLQTVDIRLAQLE DLIGRMATALERL-----------------------------------TGLERAESNKIRSRTSSDCTD--- --------------------------------------------------AAY---------IVRQSSF--- --NSQEGNT-----FKLQE------SID-------------------PAGEET-------ISPT-------- ---------------------------------------SPTLMPR-----------------MRSHSFYS- -----------------------------------VNVKDKGG-------------IEKLE----------- ----------------------------------------------------------------SIFKERSL ---------------SLH-RATSSHSV--AKE-----PKAPAAPANT------------------LAIVPDS RRPSSCIDIYVSAMDELHCDIEPLDNSMNILGL----GEP-SFSALAPSTTPSSSA---------------- --------------------------------------------YATLAPTDRPPS---------------- --------RSIDFEDLTSM-DTRSF--SSDYTHLPECQNPWDT---------DPPT----------YHTIE- RSKSSRYL--ATTP----FLLEEAPIVKSHSF-M-FSP---------------SRSYYAN------------ ------------------------------------------------------------------------ ---------------------------------FGVPVKT-------------------------------- ---------------AEYTSITD------------------------------------------------- -C------IDTR------------CVNAPQA------------IADRATF----PGGLGDKVEDLSCCHPER EAE-------------------------------LSHPSSDSEENEA------------------------- -----------RGQRAAN-------PISSQEA---ENADR-------------------------------- ---------------T-LSNNI-TVPKIERA----------------------------------------- -----------NSYSAEEPNVPYAHTRK-------------------------------------------- ------------------------------------------------------------------------ ----------------------------------------------SFSISDKLDRQRNTA----------- ------------------------------------------------------------------------ --------SLRNPFQR------------------------SKSSKPEGRGDSLSMRRLSRTSAFHSFESKHN >MmusTRPM4/1-1213 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------MVG---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --PEKEQS---------------------------------------------------------------- ----------------------------------------------WIPKIFRKKV----------CTT--- ---------------------------------------------FIVDLS-DDA----------------G GTLCQCGQP-RDAHPSV-AVEDAFGAAVV------------------------------------------- ---TEWNSDEHT---------------------------------------------------TEKPTDAYG DLDFTYSGRK---------------------------------HSNFLR----------------------- ------------------LSDRTDPATVYSL-VTRS--------WGFRAPNLVVSVLGGS-G-----GPVLQ TWLQD---------------------------------LLRRGLVRAAQST--------------------- -----------------------------------GAWIVTGGLHTGI---------------GRHVGVAV- ---RDHQTAST------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------GSS---------------- ------------------------------------------------------------------------ ----------------------KVVAMGV------------------------------------------- ----------------------------------------APWG---------------------------- --------VVRNRDML-------------INPK---GS---------------------------------- FPARYRWRGDPED-----------------GVEFPLDYNYSAFFLVDDG-------------TYGRLG-GE- ---------NRFRLRF--ES-------------YVAQQKTGVGGTG-------------------------- ----------------------------------IDIPV--LLLLIDGDEKMLKRIED--ATQAQ------- ------------------------------------------------LPCLLVAG-----------S-GGA ADCLVETLED---TLAP-GSGGLRRGEARDRIRRYFPK--GD----------------------PEVLQAQV ERIMTRK------ELLTVYS-S---------------------------EDGS-----EEF----------- -----------------------------ET-I-V--------------LRALVKACG-------------- -----------SSE----ASAYLDELRL-------------------------------------------- ------------------------------------------------------------------------ ------------AV------------------------AWNRVD---------------------------- ------IA------------QSELFRGDIQWR---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------SFHL----------------------EASLMDALLN----D------------------------R PEFVR--------------------------------LLISH-G--LSLGHFLTP--------VRL------ --------------------------------------AQLYSA--------------VSPNSL-IRNLLDQ ASH-------------ASS-SKSPPVNGTVELRPPNVGQVLRTLLGETC--------------APRYPARNT RDSYLGQDH--------------------------------------------------------------- RENDSLL------------------------------MDWANKQPSTDASFEQA--------------PWSD LLIWAL--------------LLNRA---------QMAIYFWEKGSNSVA----------------------- -SALGACLLLRVMARLESE----------------------------------------------------- -------------------------AEEAARRK--DLAATFESMSVDLFGECYHNSEE-------------R AARLLLRRCP-------------------------------------------------------------- -------------------------------------------------LWGEATCLQLAMQAD-A-----R AFFAQDGVQ-----------SLLTQK--------------------------------------WW------ ----------------GEM---DSTTPIWALL------LAFFCPPLIYTNLIVFR----KSEEEP------- -TQKDLD----------------------------------------------------------------- ----------------------------------------FDMDSSI------------------------- ---NGAGPPGTVE--------------------------------------------------PSAKVALER RQRRRPGRALCCGKFSKRWS--------DFWGAPVTAFLGNVVSYLLFLLLFAHVL-------------LVD FQ---------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------PTKPSVSELLLYFWAFTLLC---------EELR-QG--LGG---GWGSLASGGRGPDRAPLRH RLHLYL-S----------DTWNQCDLLA-------------------LTCFLLGVGCRLTP----------- ---------------------------------------------------GLFDLGRTVL----CLDFMIF TLRLLHIFT----------------------------------------------VNKQLGP--KIVIVSKM MK-DVFFFLFFLCVWLVAY--GVATEGILRPQD------------------RS------------------- -------------------------------------------LPS-ILRR--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------V----- ---------------------FYRPYLQIFGQIP--QEEMD---VA-LMIP-----GNCSMER--------- -------GSWAHP---EGPV--------------AGSCVSQYA--NWLVV----LLLIVFLLVANILLLNLL IAMFSYTFSKVHGNSDLYWKAQRYSLI------------------------REFHSR--------------- ---PALA-------PP--------------------LIIISHVRLLIK----------WLRR-------CRR CRRA----------------NLPA---------SPVFEHFRVCLSK------EAERKLLTWESVHKENFLL- -------------------------AQARDKRDSD------------------------------------- ------------SERLKRTSQK-VDTALKQL-----------G----------------QIREYDRRLRGLE REVQHCSRVLTWM----------------------------------------------------------- ------------------------AEA------------LSH--------S----------ALL-------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------PP------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------GA-P-PPPS--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------P------------------TGSK D----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >MmusTRPM5/1-1158 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --MQTTQS---------------------------------------------------------------- ----------------------------------------------SCP----------------------- ------------------------------------------------------------------------ ------GSP-PD-------TEDG------------------------------------------------- -----W-----------------------------------------------------------EPILCRG EINFGGSGKK---------------------------------RGKFVK----------------------- ------------------VPSSVAPSVLFEL-LLTE--------WHLPAPNLVVSLVGEE-R-----PLAMK SWLRD---------------------------------VLRKGLVKAAQST--------------------- -----------------------------------GAWILTSALHVGL---------------ARHVGQAV- ---RDHSLAST------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------STK---------------- ------------------------------------------------------------------------ ---------------------IRVVAIGM------------------------------------------- ----------------------------------------ASLD---------------------------- --------RILHRQLLD-----------GVHQK---ED---------------------------------- TPIHY-----PADE------------GNIQGPLCPLDSNLSHFILVESG-------------ALGSGNDGL- ---------TELQLSL--EK-------------HISQQRTGYGGTSC------------------------- ----------------------------------IQIPV--LCLLVNGDPNTLERISR--AVEQA------- ------------------------------------------------APWLILAG-----------S-GGI ADVLAALVSQP-HLLVP-QV-------AEKQFREKFPS--ECFSWEAIV-------------HWTELLQ--- -NIAAHP------HLLTVYDFE---------------------------QEGS-----EDL----------- -----------------------------DT-V-I--------------LKALVKACK-------------- ---------SHSQE----AQDYLDELKL-------------------------------------------- ------------------------------------------------------------------------ ------------AV------------------------AWDRVD---------------------------- ------IA------------KSEIFNGDVEWK---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------SCDL----------------------EEVMTDALVS----N------------------------K PDFVR--------------------------------LFVDS-G--ADMAEFLTY--------GRL------ --------------------------------------QQLYHS--------------VSPKSL-LFELLQR KHEEGRLTLA---GLGAQQ-ARELPI-GLPAFSLHEVSRVLKDFLHDACRGFYQDGRRMEERGPPKRPA--- -----GQ----------------------------------------------------------------- ----KWL------------------------------PDLSRKS--ED--------------------PWRD LFLWAV--------------LQNRY---------EMATYFWAMGREGVA----------------------- -AALAACKIIKEMSHLEKE----------------------------------------------------- -------------------------AEVARTMR--E--AKYEQLALDLFSECYGNSED-------------R AFALLVRRNH-------------------------------------------------------------- -------------------------------------------------SWSRTTCLHLATEAD-A-----K AFFAHDGVQ-----------AFLTKI--------------------------------------WW------ ----------------GDM---ATGTPILRLL------GAFTCPALIYTNLISF------SEDAP------- -QRMDLEDLQEP------------------------------------------------------------ --------------------------------------DSLDMEKSFLCSRGGQLE---------------- KLTEAPRAPGDLG--------------------------------------------------PQAAFLL-- ----------------TRWR--------KFWGAPVTVFLGNVVMYFAFLFLFTYVL-------------LVD FRPP-------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------PQGPSGSEVTLYFWVFTLVL---------EEIR-QG--FFT---DEDT-----------HLVK KFTLYV-E----------DNWNKCDMVA-------------------IFLFIVGVTCRMVP----------- ---------------------------------------------------SVFEAGRTVL----AIDFMVF TLRLIHIFA----------------------------------------------IHKQLGP--KIIIVERM MK-DVFFFLFFLSVWLVAY--GVTTQALLHPHD------------------GR------------------- -------------------------------------------LEW-IFRR--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------V----- ---------------------LYRPYLQIFGQIP--LDEID---EA-RV--------NCSL----------- -----------HPLLLES----------------SASCPNLYA--NWLVI----LLLVTFLLVTNVLLMNLL IAMFSYTFQVVQGNADMFWKFQRYHLI------------------------VEYHGR--------------- ---PALA-------PP--------------------FILLSHLSLVLK----------QVFR-------KEA QHKR---------------------------------QHLERDLPD------PLDQKIITWETVQKENFLS- -------------------------TMEKRRRDSE------------------------------------- ------------GEVLRKTAHR-VDLIAKYI-----------G----------------GLREQEKRIKCLE SQANYCMLLLSSM----------------------------------------------------------- ------------------------TDT------------LA------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------P------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------GG-T-YSSSQNCGCR--------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------SQP------------------ASAR DREY-----LESGL---------------------------------------------------------- ------------------------------------------------------------------P----- ---------------P-SDT---------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >MmusTRPM6/1-2028 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --MQVKKS---------------------------------------------------------------- ----------------------------------------------WIEGVFYKRE----------CNK--- ---------------------------------------------FIPSSK-DPHRCT--PGCQICHNLV-- --RCYCGRL-IEEHHGL-DRAWNLSVTE-------------------------------------------G HGDEQWSVEKHT---------------------------------------------------VKSPTDTFG TINFQDGEHI--------------------------------HHSKYIR----------------------- ------------------TSWDTKSDHLLHL-MLKE--------WNMELPKLVISVHGGL-Q-----NFKIS SKLKE---------------------------------TFSQGLVKAAETT--------------------- -----------------------------------GAWIITEGINSGV---------------SKHVGDAL- ---KAHSSK--------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------SLR---------------- ------------------------------------------------------------------------ ----------------------KIWTVGI------------------------------------------- ----------------------------------------PPWG---------------------------- --------VIENQREL-------------VG-----KD---------------------------------- VVCMY----QTLG--------------NPLSKLTTLNCMHSHFILCDDG-------------TVGMYG-NE- ---------EKLRRNL--EK-------------HLSMQKIHTCSRQ-------------------------- -----------------------------------GVPV--VGLVMEGGPNVILWVWE--TVKNKE------ -------------------------------------------------PVVVCEG-----------T-GRA ADLLAFTYKHLEDG-------GILRPQVKEELFCLIQNMFNFSLRQSKH-------------LFQILME--- --CMVHK------DSITIFDAD---------------------------SEEH-----QDL----------- -----------------------------DL-A-I--------------LTALLKGTS-------------- ---------LSISE----------QLNL-------------------------------------------- ------------------------------------------------------------------------ ------------AM------------------------AWDRMD---------------------------- ------IA------------KKHILTYGQHWK---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------PGAL----------------------EQAMLDALVM----D------------------------R VDFVK--------------------------------LLIEN-G--VNLHRFLTI--------PRL------ --------------------------------------EELYNT-------------KQGPTNKFLRHLVQD --------------------VKQHTLLSSYRITLIDIGLVIEYLIGGAYRSSYT-----------RKSFRIL YNNL----Y------------RKHKSVSSFAQ------------GLSQHSLHQRH-SLR--------NRK-- ESSESTLHSQFFRT-------AQPYKSKE---------KPEDSQKSKKKSKERQSLSEEPEAAGFI-YPYND LLVWAV--------------LMKRQ---------NMAMFFWQHGEEATV----------------------- -KAVIASILYRAMAREAKES---------------------------------------------------- ----------------------NMVDDTSEELK--NYSEQFGQLALDVLEKAFKQNEP-------------M AMKLLTYELK-------------------------------------------------------------- -------------------------------------------------NWSNSTCLKLAVSGG-L-----R PFVSHSCTQ-----------MLLTDM--------------------------------------WM------ ----------------GRLK--MRKNSWLKII------ISILLPPMIL--TLEFK----------------- -SKAEMSHVPQSQD-FQF------------------------TWNYSDQGLS-------------------- ---NTKESA-------------------------------CVKDYDLERGPDEKPD-EPLHLDL-------- -------------------------------------------------------------------RNVPQ SLPWT-----------RRVY--------EFYSAPFVKFWFYTMAYLAFLMLFTYTV-------------LVE MQP--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------QPSVHEWLVIIYIFTNAI---------EKVR-EI--CIS----EPS-----------KFKQ KVKMWL-S----------EYWNLMETVA-------------------IGLFAVGFGLRWG------------ -------------------------------------------------HPPLQTAGRLIY----CIDIIFW FSRLMDFFA----------------------------------------------VNQHAGP--YVTMIAKM AA-NMFYIVIIMAIVLLSF--GVARKAILSPK-------------------EP------------------- -------------------------------------------PSWRLARD--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------I----- ---------------------VFEPYWMMYGEVY--ASDID----V------------CSN----------- -------ETS----CPPGS---------------------------FLTP----FLQAVYLFVQYIIMVNLL IACFNNIYLDIKSISNKLWKYNRYRYI------------------------MTYHQK--------------- ---PWLP-------PP--------------------FILLNHLCLLLR---------GLCCR---------- --PA----------------PQDQ---------EEGDGGLKLYLTK------DDLKKLHDFEEQCVEKYFH- -------------------------EKTEGLNCSF------------------------------------- ------------EEQIRMTSER-VSEMFFQLKEMNEKVSFIKD----------------SLLSLDSQVGHLQ DLSAITVDTLKVLSAVDTLQED------EILLANRKHSTC-------------------RKRPHSWTNVI-- -----------------------CAKV------------LSD--MESCGKKKL-QYYSMPPSLLRSLA---- -------------RSQLPPSVQRGALVEVTHSKREASH------VREEQEERE-------MEQRTTASGISH VRQAHSKYGQFLLVPSSGKQVPL------------SLETPPHL-------------------FRSSEEAGID GLVLEHIHQSDLTTHLPQQTPAASHQALVAEHKDQHEAVTQMS-------------DKPAKAEQDLLAFS-G TPA-PMTVTSLPSRAISMQDEGGYVNWAFSENDETGVFSFKKKWKTCLASTCNSDSNPGGDYFLHTGGRSGL ---------------DNSRRLAQSCEC----------PAGPWTQARRSFWINPLCRDKALIKSHSFRFHKEE KLRKTW-----------------------------------KNNSHSKSLETRSTWLKAKLLT--------- ---------------------------KTRSLSKKK-------RKTQGLQVPVITVN--------------- ------ACYQS--DQLNAE-PGETN--TTEEFSKK-----WLSVSNFSQIGLEPYIYQKMKMKEIKRHTTQ- ASDHLRQ--PQENR------DKTPT-WNSGST-S-LSRSFL------------TRS---------------- ------------------------------------------------------------------------ ------------------------------------PNEVHKISTSLKS---------PQEP---------- --------------HHHYSAIERNNL-----------------------------------------MRLSQ TI------PFTPIQLF------TGEEVTIYKLEESSPLTLDKSMSSWSQH------GRAAMIQVL------- SQEE-----MDGGLRKAM---------------RVISTWSEDD---------------VLKPGQVFIVKSFL PEVVQTWYKIFQESTVLHL------CLREIQQ--QRAAQKLIY----------TF-------------NQVK ---------------P-QTIPY--TPRFLEV-------------------------------SL-VYCHSAN -----------QWLTIEKYMTGEFRKYNNNNGDEIAPTNTL---------EELML---------AFSHWTYE YTRGEL----------------------------------LVLD------LQGVGENL-------------- ----------------------------------------------TDPSVIKPEDKQSRGMVFGPANLG-- ---------------------------------------------------EDAIRSFIA-----------K HRCNSCCGKLRLPDLKRNDYSLSR--------THCNLGFGQTIEPTEELPERDKNRSSLEDHTRL------- >MmusTRPM7/1-1863 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---MSQKS---------------------------------------------------------------- ----------------------------------------------WIESTLTKRE----------CVY--- ---------------------------------------------IIPSSK-DPHRCL--PGCQICQQLV-- --RCFCGRL-VKQHACF-TASLAMKYSDVKLG------------------------------------EHFN QAIEEWSVEKHT---------------------------------------------------EQSPTDAYG VINFQGGSHS--------------------------------YRAKYVR----------------------- ------------------LSYDTKPEIILQL-LLKE--------WQMELPKLVISVHGGM-Q-----KFELH PRIKQ---------------------------------LLGKGLIKAAVTT--------------------- -----------------------------------GAWILTGGVNTGV---------------AKHVGDAL- ---KEHASR--------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------SSR---------------- ------------------------------------------------------------------------ ----------------------KICTIGI------------------------------------------- ----------------------------------------APWG---------------------------- --------VIENRNDL-------------VG-----RD---------------------------------- VVAPY----QTLL--------------NPLSKLNVLNNLHSHFILVDDG-------------TVGKYG-AE- ---------VRLRREL--EK-------------TINQQRIHARIGQ-------------------------- -----------------------------------GVPV--VALIFEGGPNVILTVLE--YLQESP------ -----------------------------------------------PVPVVVCEG-----------T-GRA ADLLAYIHKQTEEG-------GNLPDAAEPDIISTIKKTFNFGQSEAVH-------------LFQTMME--- --CMKKK------ELITVFHIG---------------------------SEDH-----QDI----------- -----------------------------DV-A-I--------------LTALLKGTN-------------- ---------ASAFD----------QLIL-------------------------------------------- ------------------------------------------------------------------------ ------------TL------------------------AWDRVD---------------------------- ------IA------------KNHVFVYGQQWL---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------VGSL----------------------EQAMLDALVM----D------------------------R VSFVK--------------------------------LLIEN-G--VSMHKFLTI--------PRL------ --------------------------------------EELYNT-------------KQGPTNPMLFHLIRD --------------------VKQGNLPPGYKITLIDIGLVIEYLMGGTYRCTYT-----------RKRFRLI YNSLGGNNR------------RSGRNTSS-----------------STPQLRKSHETFG--------NRA-- DKKEKMRHNHFIKT-------AQPYRPKM---------DASMEEGKKKRTKDEIVDIDDPETKRFP-YPLNE LLIWAC--------------LMKRQ---------VMARFLWQHGEESMA----------------------- -KALVACKIYRSMAYEAKQS---------------------------------------------------- ----------------------DLVDDTSEELK--QYSNDFGQLAVELLEQSFRQDET-------------M AMKLLTYELK-------------------------------------------------------------- -------------------------------------------------NWSNSTCLKLAVSSR-L-----R PFVAHTCTQ-----------MLLSDM--------------------------------------WM------ ----------------GRLN--MRKNSWYKVI------LSILVPPAIL--MLEYK----------------- -TKAEMSHIPQSQDAHQM------------------------TMEDSENNFH-------------------- ---NITEEIP----------------------------MEVFKEVKILDSSDGKNE-MEIHIK--------- ----------------------------------------------------------------------SK KLPIT-----------RKFY--------AFYHAPIVKFWFNTLAYLGFLMLYTFVV-------------LVK MEQ--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------LPSVQEWIVIAYIFTYAI---------EKVR-EV--FMS----EAG-----------KISQ KIKVWF-S----------DYFNVSDTIA-------------------IISFFVGFGLRFGAKWNYIN----- --------------------------------A-------------YDNH--VFVAGRLIY----CLNIIFW YVRLLDFLA----------------------------------------------VNQQAGP--YVMMIGKM VA-NMFYIVVIMALVLLSF--GVPRKAILYPH-------------------EE------------------- -------------------------------------------PSWSLAKD--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------I----- ---------------------VFHPYWMIFGEVY--AYEID----V------------CAN----------- -------DSTLPTICGPGT---------------------------WLTP----FLQAVYLFVQYIIMVNLL IAFFNNVYLQVKAISNIVWKYQRYHFI------------------------MAYHEK--------------- ---PVLP-------PP--------------------LIILSHIVSL------------FCCV---------- --CK----------------RRKK---------DKTSDGPKLFLTE------EDQKKLHDFEEQCVEMYFD- -------------------------EKDDKFNSGS------------------------------------- ------------EERIRVTFER-VEQMSIQIKEVGDRVNYIKR----------------SLQSLDSQIGHLQ DLSALTVDTLKTLTAQKASE------------ASKVHNEI--------------------TRELSISKHL-- -----------------------AQNL------------IDDVPVRPLWKK---------PSAVNTLS---- --------------SSLPQG------------DRESNNPFLCNIFMKDEKDPQ------------------- ----YNLFGQDLPVIPQRKEFNIPEAGSSCGALFPSAVSPPELRQRRHG-------VEMLKIFNKNQKLGSS ----------------PNSSP-------------------HMS-------------SPPTK-------FSVS TPSQPSCKSHLES--TTKDQEPIFYKAAEGDNIEFGAF---------------------------VGHRDSM ---------------DLQ-RFKET----------------------------------------------SN KIRELL-----------------------------------SNDTPENTLK--------------------- -------------------------------------------------HVGAAGYS--------------- ------ECCK-------------TS--TS-------------------------------------LHSVQA ESCSRRA--STED---------SPE-VDSKAA-L-LPDWLR------------DRPSNR------------- ------------------------------------------------------------------------ ----------------------------------EMPSEGGTLN-GLAS---------PFKPVLD------- -------------TNYYYSAVERNNL-----------------------------------------MRLSQ SI------PFVPVPP-------RGEPVTVYRLEESSPSILNNSMSSWSQL------GLCAKIEFL------- SKEE-----MGGGLRRAV---------------KVLCTWSEHD---------------ILKSGHLYIIKSFL PEVINTWSSIYKEDTVLHL------CLREIQQ--QRAAQKLTF----------AF-------------NQMK ---------------P-KSIPY--SPRFLEV-------------------------------FL-LYCHSAG -----------QWFAVEECMTGEFRKYNNNNGDEIIPTNTL---------EEIML---------AFSHWTYE YTRGEL----------------------------------LVLD------LQGVGENL-------------- ----------------------------------------------TDPSVIKAEEKRSCDMVFGPANLG-- ---------------------------------------------------EDAIKNFRA-----------K HHCNSCCRKLKLPDLKRNDYTPDKIIFPQDESSDLNLQSGNSTKESEA-----------TNSVRLML----- >MmusTRPM8/1-1104 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------MSFEGARL------------------ ---------------------------------SMRSRRNGTMGSTRTLYSS-------------------- ----------------------------------------------------------------VSRSTD-- -----------------------------------------------------------------------V SYS--------------------------------------------------------------------- --DSDLVN---------------------------------------------------------------- ----------------------------------------------FIQANFKKRE----------CVF--- ---------------------------------------------FTRDSK---A----------------M ENICKCGYA-QSQH-----IE---GTQINQ------------------------------------------ --NEKWNYKKHT---------------------------------------------------KEFPTDAFG DIQFETLGKK----------------------------------GKYLR----------------------- ------------------LSCDTDSETLYEL-LTQH--------WHLKTPNLVISVTGGA-K-----NFALK PRMRK---------------------------------IFSR-LIYIAQSK--------------------- -----------------------------------GAWILTGGTHYGL---------------MKYIGEVV- ---RDNTISRN------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------SEE---------------- ------------------------------------------------------------------------ ----------------------NIVAIGI------------------------------------------- ----------------------------------------AAWG---------------------------- --------MVSNRDTL-------------IRSCDDEGH---------------------------------- FSAQY-----IMDD-------------FTRDPLYILDNNHTHLLLVDNG-------------CHGHPT-VE- ---------AKLRNQL--EK-------------YISERTSQDSNYG-------------------------- ----------------------------------GKIPI--VCFAQGGGRETLKAINT--SVKSK------- ------------------------------------------------IPCVVVEG-----------S-GQI ADVIASLVEVE-DVLTS-SM-------VKEKLVRFLPRTVSRLPEEEIE-------------SWIKWLK--- -EILESS------HLLTVIKME---------------------------EAGD-----EIV----------- -----------------------------SN-A-I--------------SYALYKAFS-------------- ---------TNEQD----KDNWNGQLKL-------------------------------------------- ------------------------------------------------------------------------ ------------LL------------------------EWNQLD---------------------------- ------LA------------SDEIFTNDRRWE---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------SADL----------------------QEVMFTALIK----D------------------------R PKFVR--------------------------------LFLEN-G--LNLQKFLTN--------EVL------ --------------------------------------TELFST---------------HFSTL-VYRNLQ- ---------------IAKN----SYNDALLTFVWKLVANFRRSFWKED------------------RSSRED ------------------------------------------------------------------------ ----------------------------------------LDVE-LHDASL------TTRH-------PLQA LFIWAI--------------LQNKK---------ELSKVIWEQTKGCTL----------------------- -AALGASKLLKTLAKVKND----------------------------------------------------- -------------------------INAAGESE--ELANEYETRAVELFTECYSNDED-------------L AEQLLVYSCE-------------------------------------------------------------- -------------------------------------------------AWGGSNCLELAVEAT-D-----Q HFIAQPGVQ-----------NFLSKQ--------------------------------------WY------ ----------------GEI---SRDTKNWKII------LCLFIIPLVGCGLVSFR----------------- --KKPID----------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------------K HKK-------------LLWYY------VAFFTSPFVVFSWNVVFYIAFLLLFAYVL-------------LMD FHS--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------VPHTPELILYALVFVLFC---------DEVR-QW--YMN---------------------- -GVNYF-T----------DLWNVMDTLG-------------------LFYFIAGIVFRLHSS---------- -------------------------------------------------NKSSLYSGRVIF----CLDYIIF TLRLIHIFT----------------------------------------------VSRNLGP--KIIMLQRM LI-DVFFFLFLFAVWMVAF--GVARQGILRQNE------------------QR------------------- -------------------------------------------WRW-IFRS--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------V----- ---------------------IYEPYLAMFGQVP--SD-VD---ST-TYDF-----SHCTFSG--------- -------NES-KPLCVELD---------------EHNLPR-FP--EWITI----PLVCIYMLSTNILLVNLL VAMFGYTVGIVQENNDQVWKFQRYFLV------------------------QEYCNR--------------- ---LNIP-------FP--------------------FVVFAYFYMVVK----------KCFK-------CCC KEKN---------------------------------MESNACCFR------NEDNETLAWEGVMKENYLV- ------------------------------------------------------------------------ ---------------------K-INT----------------K----------------ANDNSEE------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------MRH----------------------R-------F--- ------------------------------------------------------------------------ ------------------------------------------------------------------------ RQLDSK-----------------------------------LND---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------LKSLL---------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------KEIANNIK--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ >NvHsTRPA/1-902 ------------------------------------------------------------------------ --MS-------------------------------------------------------------------- ------------------------------------------------------------------------ ---RSWKLDEVVE----------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------EDPS-------- -------------------------------------------D--------------------------RV DMSDLN------------------------------------------------------------------ --RAPRSPRSEC------------------------------------------------------------ -------------------------------------------------RKPRHYS-L-------GCIY--- ------------------------------------------------ERQRRT------------------ ------------SR------------D----LLPGRL----------------------------ASLYKSR QGMRPSICPDKVVVTE--PQ---------------------------------DSA-EHVEIDAGAPPPVDD SLFFDREF------------------------------------EALKH----------------------- ------------VK----IDGTSLKTAMWAA-VNVV----------------------EM-K--------DL LEMEK------------------------------------GNIEKGPDGKLLP-N--ADQR---------- ------------------------------------------FKNVMFLWACFRGLAHLLPKLEEC-GADR- ---DYVEPC--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------TGM--------------------------------------------------------- NPILV---------------------ASLTS-----SIACLEYLIE--------------------KG-AD- ---------VNYANT---ALF--------------------------------------------------- -----------------------------------YTPL--HFAAFGNSSEAAELLIK-------------- --------------------------------------------HGA--KLNSS------NCQDV-----EP VLHCAVRARA-------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------EKVVK---------------------------- ------LLL---------EKAASVAQKN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---STGETPL--------------------------HVACFV----Q------------------------S IGCTE--------------------------------LLLCS-PG-TDPN-AVDQ-------NHR------- --------------------------------------TPLHYAVMN----------TCSAPEL-VELLLKH GAA------------------------------------------VNVKDK-Q------------------- --------------------------ELT------------------------------------------- --------------------------------------------------------------------PLHI AS------------------LNEQS---------QCVDALIWAGADVSA-TTK------------------- -TGLTALNII-------------------------------------------------------------- -------------------------------LR--KIP-ESLQVFRQRLDASIRLKRPV-------PH-NRE FEMRLHFDL--------------------------------------------------------------- LFPS--------------------------------------------NNQCETSFINTFVQEH-Q-----K DLLSHPLVM-----------AFLHLK--------------------------------------WE------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------K------------------- ----------------IRKF-----------------YLMRIFLYALTVIVMTTYV-------------LTA L-------------------------------------------------AYRCY----------------- -NL-----------SESKSS---------------------------------KIC---------------- ------------------------------------------------------------------------ ----NNNRASGFLFRRH------------------------------------VIE---------------- --------------IEWYVSLILTCVTIP---------RKIF-GFMVYK----------------------- SARQYF-M----------NIDNVLDA-I----------------------VIVSVFVTSF------------ ----------IYTG-----------------R-----------TY-DWQN--------YVG----AFAILCA WTNLMLMVG----------------------------------------------QLPAFGT--YVAMFTHI QF-EFAKLLLAYSGLLIGF--TISFCVIF----------------------VG------------------- --EPS-------------------------------------------FGN-P------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------FTG----- ---------------------LIKVLAMMAGELD--FEGLINQDD--------------ILH---------- -------DG---SFVLYH----------------------PL---SVCSQ----ILFTLFIVFVTVILMNLL VGIAVHDIQGLRNHAGLTKLVRQTKLI------------------------LFTEMVLYNGRI--------- ------P------------------------------------YTFK----------KWMS----------- --DH-KID----------------------------VDNRKRV--------------------LVV------ --------------------------KPLNPLEKR------------------------------------- -----------------LPKDI-MKAA--------YEI-------------------------AQRN-A-PL VDEDD---------------------------VSLDEH-------------VTWMKQQSEE----------- -------------------------------------GSDYL--LHS------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------TID--------------------QLSTQ---------- ---------------------------------------------------------------MKSAEDD-- ------------------------IK-----------------VI--------------------------- ------------------------------------------KEQLLDTNK--------------------- ------------------------------------------------------------------------ -----------MLKNLVAR----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------RVQ PR---------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >NvIav/1-1435 ------------------------------------------------------------------------ --M-GGACS--------------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------------------CQG------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------RDSQVN------ ------------------------------------------------------------------------ --------------------------------------------------------------A-GSIL---- DRVISQAS---------------------------------------------------------------- ---------------------------------------------DEDQCLLYRLA---------------- ------------------------NYKKGGELIEA------------------------------------- --------YNQGGQ---------------------------------------------------------- ------AEVERL------------------------------------------------------------ ------------------------------------------IREQFGIL---------------------- --------------------------------MYAD---------------------GKG-Q-----TINRA EYLRWKFRD--------------------------------------LDQVILPIE---------------- --------------------------------------------------------------------ASL- ---SRFDPL--------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------AQ----------------- --------------------------------------------WSD------------------------- -------------------------------------------------------------HE--------- ----------------------------------------ACWQ---------------------------- ---------MQYRGSLG-------------------E----------------------------------- TLLHV-------------------------------------LIIC-------------------------- ------------------------------------------------------------------------ -----------------------------------DTRT--HTR-------IARTLLK-------------- ---CF---------------------------------------PRLAIDVVEGEEYL-----------GAS ALHLAI------------------------------------------------------------------ --AYAN------NELVQDLVE-----------------------------AGA------IVSQRAIGSFFLP RDQQRPRP-------------------AKS--T-----DYEGLAY--LGEYPLAWAAC-------------- ---------CANESVY--------NLLLDS-GAH-------------------------------------- ------------PD---------------------------------------------------------- ----EQDTFGNSIL--------HMVVV---------CDKLVRFG---------------------------- ------YALR------HPKLPASNGIAN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---AAGLTPL--------------------------TLACQL----G------------------------R AEVFR--------------------------------EMLEL---------SARE-------FWRY------ --------------------------------------SNITCSA--------------------------- -------------------------------------------YPLNALDTLLP------------------ -------------------------DGRT------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -SXNSALFII-------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ LNGTKEE----------------------------------------------------------H-----L DMLDGGIIQ-----------RLLEEK--------------------------------------WK------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------T------------------- ---------------FARLQ-----------------FLKRLVILVFHLVSLSLAV-------------YFR PA---------------------------------------------------------------------- -------------------------------DTDAE------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------LAQ----------WPEE-- -----------ITDV---VRVIAECVTVL---------GVLG-YI-LLQL--------GGE-------IVNI GFFSFF-K----------QLSHEPAKFI----------------------FLISNLLILACIPCRLS----- -----------------------------GDRH--------------TED--------AIL----VVAVPGS WFLLMFFAG----------------------------------------------AVRLTGP-FVTMVYSMI LG-DMRTFGIIYMIVICGF--TQAFYFLY----------------------KGY------------------ PGVKT-----------------------------------------TLFHS-Y------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------PST----- ---------------------WMALFQITLGDYS--YSDLSMT----------------------------- ----------------------------------------TY---PNLSK----AVFTIFMVLVPILLLNML IAMMGNTYAHVIEQSEKEWMKQWAKIV------------------------VSLERAVSQDDAHNYLQ---- --EYSIKLGPGDDPND---------------------PASEQRGVMVI---------KSKSK---------- -TRA----------------RQRKGA----------VANWKRV------------------GKVTIAELKKR GMTGEELRRIMWG-RASFS-------TPVRSSPILMEP-------VSSVP---------------------- ---------------GGFGDAL-TSALDV-MTFA-ADVPVPIEGSIPKPVAVAPGQQPTTTLALP-NGAAKP QQPMMTTSTTTTT----------------------ITTTVQ---------KTLVTGTATTPAVGVTKTVAVP AATTVST------TTTRASASAVPPTV---RPSELGPASAPC--SADPLL-----------ELMLATE---- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------DP---------------------------------- ---------------------------------------------------------------GSS------ ---------------------EETLQ-----------------RL--------------------AHSARIV GESATTS---AKSD----IDSSFLERLAL-GGLGLAAMPEQPDKPVEPKKKQYLA---------LKSSLKSD RASLQHPLS------------------HDGQLGT-------------------------------------- ---------EARLRRIRSASSRLAPTTTTSTSRRKS------------------------------------ GQQKQQR--EARDD------------ESTSSAAS-LDNISGYQPLLNEPDTTADQPATGTEDNKPANGRNLR KRPKTTSNEGKVFCSRRTIVVLNKNKKNKKLETSEANMNARKKETLLALHDMTSLISDNWIQINIARFQNNY SHSKVTKNLKKCHLHIES--DVLLTSQQC------------------------------------------- -------------------CINI------------------------------------------------- -----------------------------------SNS-----------------------------KAKMN QALLVV-----------------------LSFFVVNEDQPVAGW--------TWGKSATSSS---------- -------------------------NNSINDD--RARYCRICA-SHTMCLF--PYDDPGPKCAAVEN-GDLE ---------------P-EEIEWILQ----------------------------------------------- ------------RHNSLRDGIARAWKSQYRP---LPARDMM------------------------------- ---------------------------------------QVFWDEE----LAKIARRWALQCNIHEKDQCRD VEEFSVAQSVSALDLQDAGNRSEMERLKFHLRSWYSQLEPDFSNSAGVGLATPSVTNVGCGRATYSVAI--- --------------------------------------------------DDSDVAAAVEVLV--------- -----CNYGPIDDPETEDDSGCETRSRRYSE--------LCQLTRRE------------------------- >NvNan/1-832 ------------------------------------------------------------------------ --MGNAESNV-------------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------------------TSG------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------VKKQT------- ------------------------------------------------------------------------ --------------------------------------------------------------DAGA------ ------------------------------------------------------------------------ -------------------------------------------------IALYKLV---------------- ------------------------DLKGGGLLVDM------------------------------------- --------MKRASQTK-------------------------------------------------------- ----QYAEIDHA------------------------------------------------------------ ------------------------------------------IRTKVEPF---------------------- --------------------------------LYNG---------------------GKG-K-----WIPIA KLVLLRNKER-------------------------------------GRHKMLPVL---------------- --------------------------------------------------------------------KAM- ---EKP------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------ED----------------- --------------------------------------------YDI-DKD-----------MANDPEPDEN TIG---------------MMIMKIL-------SNKSKY-----------------------KL--------- ----------------------------------------VCWT---------------------------- ---------LSDRGAVG-------------------E----------------------------------- TILHL-------------------------------------CMLN-------------------------- ------------------------------------------------------------------------ -----------------------------------ATQL--HAD-------LAKRLLR-------------- ---FY---------------------------------------PNLINDIYIDDEYY-----------GEN VLHIAI------------------------------------------------------------------ --VNED------PSMVKFLLD-----------------------------SGA------NVNERCCGNFMCP EDQKASRNDS---------VEHEWVCVCSE--T-----NYDGYVY--WGEYPLSFAAC-------------- ---------LDQEECY--------RLILAK-GAD-------------------------------------- ------------PD---------------------------------------------------------- ----SQDTNGNTVL--------HMLVI---------YEKLETFD---------------------------- ------MAY---------EVGSSLSIRN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---VLQLTPL--------------------------TLAAKL----A------------------------R VEMFF--------------------------------HILNI---------EREI-------YWQI------ --------------------------------------GSITCAA--------------------------- -------------------------------------------YPLSQIDTIDV------------------ ------------------------DTGKI------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -SNNSALNLV-------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ VFGDKEE----------------------------------------------------------H-----L KLLEG-VLI-----------DLLNAK--------------------------------------WN------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------T------------------- ---------------FVKSR-----------------FYQQFYLFFCYFILSLISC-------------TLR PG---P-ITKTDAPTTTPHPMN-------------------------------------------------- -DTSL-----------YADV-------N---ETSA---------SDPFDLNASDIVILKKGK---------- ------------------------------------------------------------------------ -----------------KE-------------------LDDWWDDLTED--CRLMQ-------MNSTSAK-- ------------------IRLTAEIFMEF---------GAIL-YI--CAA--------LRE-------ARFL GLNMFI-E----------NLMTAPSRVM----------------------FLFSCCILLSFPFLRMS----- -----------------------------CADE--------------VED--------ILA----VVVMLTT APYFLFFCR----------------------------------------------GFKTVGP-FVVMIYRMI MG-DLLRFVSIYLVFVMGF--SQAYYIIF----------------------LSF------------------ DNPIT------------PEGVDDS--------------------KANPLPS-A------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------MES----- ---------------------IMAMFLMSMTNFGDYYDAFENT----------------------------- ----------------------------------------EH---EMLAK----CLFVVYMAIVSVLLVNML IAMMGNTYQK-IAETRNEWQRQWARIV------------------------LVVERGVAPAERLKKLN---- --VYSQPMSDGRK-----------------------------ALVLRL---------NQT-D---------- -KDK----------------EEMKDI-----------LEMKRI------------------HIKSIKRRKDK LQK--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------AKED----------------------------------------------- ------------------------------------------------------------------AEKLQQ QMA--------------------------------------------------------------------- ---------------------------DKDNK--D------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------KAV-------------------IIQ---------------------------- >NvNompC/1-1711 ------------------------------------------------------------------------ --MSSSKKG---------------------------------GGKE-------------------------- ------------------------------------------------------------------------ EGKKRGAGA--------------------------------------AV----------------------- ----------------------------SGDVGGPSSKEDSPAGAGGLAGKDGEPGSAG------------- ---------GSG--SGAA-------------SNGAPS----------------AEPSQPGSKP--------- ----------------------------------------------GSAGAT----------AREAAQR-LL GVATRGEWT-----AADQLLKTLEKAVQSAG-DEANLQPLAGLADPQTGMTPLMYAVKDNR---TAFL---- DRMIELGADVGARNLDNYNALHISAMFS----REDVVKLLLSKRGVDPYAPGGPRQQTAVHLVASRQTGTAT SILRVLLAAAGRDIRMKVD-------------GKGKIPLLLAVEAGNQS-MCREL--L-------------- -------------------------SQQAPDQLK-----------AT-TPTGDTA----------------- --------LHLAAR---------RRDVDMVRILVDYGA---------------------------------- ----SVDMQNGS---------------------------------------------------GQTALHIAS ---------------------------------AEGDET--------------------------------- -----LVKYFYGVR----ASAAITDHLDRTP-MHLA-AEN-----------------GHA-S--------II ELLADKFK-A--------------------------------SIFERTKDG--------------------- --------------------------------------------STLMHIASLNGHSECATMLFKK-GVYL- ---HMPNK---------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------KGA--------------------------------------------------------- RSIHT---------------------AAKYG-----HVGIISTLLQ--------------------RG-EK- ---------VDATTN---DNYTAL---------HIAVESAKPAVVETLLGYGAEVHVRGGKLRETPLHIAAR VPD--GDRCALMLLKSGAGPNLATDDG--------QTPV--HVAASHGNLATLKLLLE-----DGGDPMFKS K-------NGETPLHLACRGCRA---DVVRHLIEFVKEKKGVDVATN--YVNSLTF-----------E-GAS ALHYAAQIEP-------------------------------------------------------TEVV--- -VEGDDR------AVVRALLE-----------------------------GGA------DVSLQTKQAQESA FHYCALAGNNEVLSEMIGHMSATEVQKALNR-Q-----SAVGW-------TPLLIAAH-------------- ---------RGHMDIV--------KNLLEN-HAR-VDVFDLEGRSALHLAAEHGYLEVCDALLAN------- --------------------------------------------KAFIN----------------------- ----SKSRVGRTAL--------HLAAM---------NGNTHLVRFLVQDHQAAIDVLTLRKQTPLHLAAGAG QLQVCKLLL---------DLGASIDATDDQGQKPIHAAAMNNYAEVAQLFLQ---KHPSLVMACTKDGNTCA HIAAMQGSVRVIEELMKFDRNGVITARNKLTEATPLQLAAEGGHAEVVRALVRAGASCAEENRAGFTAVHLA AQHGHGQVLDVMMR--SSQSLRISSKKLGVTALHVAAYFGQADTVRELLTHVPGTVKSEPPT---GGSLVGE LGNESGMTPL--------------------------HLAAYS----G------------------------N ENVVR--------------------------------LLLNSAG--VQVEAATTE-------NGF------- --------------------------------------NPLHLGL------------SGGPISI-GAAF--R EIE-----------------------------------------FVRAIER--------------------- --------------------------SKK------------------------------------------- --------------------------------------------------------------------GLYC AGI-----------------FHSSI---------QVKRMRL--SPRIRK-AHR------------------- -HMYTRAHCV---LAFGN-------------------------------------KSLESKRVCVRVCITQ- ---------------------------LDMIFD--DEV-VFRSTVFL---S--------------------- ---QFVYNM------------MVCS----KSHNNKPIEEFVLVSPAPVDTA-AKLSNIYMKLSEKEKERAKD LIAAGKQC-----------------EAMATELLALAAGADSAGRILTSMDRRNVEFLDVLIENE-Q-----K EVIAHTVVQ-----------RYLQEL--------------------------------------WR------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------G------------------- ---------------SLNWN-----------------GFRTILLFIVFVICPPVWM-------------VFA L----------------------------------------------------------------------- --------------PLGHKY-------N---NV--------------------------------------- ------------------------------------------------------------------------ ----------------------------------------------------PIIKFM-------------- -----------AYLTSHIYLMVFLALVGI---------LPIY-PV--NRE---------P------------ -------L----------TP-YWYEWCLLVMLSGLLLFELTNPSDKSGLGWIKLAVLLFGICGVFVHLLGQS ---------GLV-------------------------KKNDWGTLLYIRN--------QFF----ALSFLLA CVQILDFLS----------------------------------------------FHHLFGP--WAIIIGNL MK-DLARFLAVLAIFVFGF--SMHFVAL-------------------------------------------- --NQA-------------------------------------------FK---------------------- -------------------EG-----------------------------------------KQK--DTNK- ---RPAFSDGKFE-------------------------------------MVAQNLTEW----EMIDIPPPQ PTPRENYISEISSAKSNTSKLNMKMNPVLAFEYL--FFAVF------------------GQTT--------- ------HSE-LKVEQ-------------------------NQ---PEWTSSLFKLAFGVYMLVSVVVLINLL IAMMSDTYQRIQKR---------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------KQ--------------------------KKD----- -------------------------------RPSLVNM-----------MG-LRQGGRLSAR---------- --------------------------------SKAGTKWLSK--VKK------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------TSQ----------------------------------- ------------------------------------------------------------------VAHK-- ---------------------DSVTL-----------------SV--------------------MHLSP-- ---------------------------------------------LGSQLSF-------------GNATRIE SVVD------------------------WDVV---------------------------------------- ---------RRKYRELQGE----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------VSDK------------------------------------------------ ---------------------------------------------------------------------SGM DSK--------------------------------------------------------------------- ---------------------------DDSES--DSQLM------------------------------PVD ---------------D-ASPSLVG------------------------------------------------ -------------SQATLIASTS------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >NvPain/1-707 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------MDSEDEALEMQ---------------- ---------------------------------------------LLQEQNADR------------------ ------------------------------------------------------------------------ -------------------------------------------------------------------Y---- ------------------------------------------------TP---------------------- --------------------------------LMHL-LKN-----------------NHL-A-------TFK SFVRQALN------------------------------RQPPSIDVN------------------------- ------------------------------------------------HL-----------LSYP------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------EHR--------------------------------------------------------- TFLDA---------------------AASLNL-----PNFVAFLLE--------------------VG-AN- ---------PN--LIN-SERN--------------------------------------------------- -----------------------------------RAPI--HFAAEAGHSEALEALLK-------------- --------------------------------------------DRRV-NLNL-EA-----------G-GLT ALHYAVK----------------------------------------------------------------- ----AD----CG-ICTRLLLD-----------------------------AGA------SP----------- -----------------------------NI-P-----ND-------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------KGNS------------------------------------------- --------------------------------------------------------------------PLHY AAR------------------AENR---------EAIELLLQKGCYVGH-MNS------------------- -FGSPPLAHMA------------------------------------------------------------- -----------------------------------------PGILEPHLDECLTSSN----------ERTEE YEIIMNYQN--------------------------------------------------------------- LVPHNTQC---------------GADVSYLERNRRRSSFKNRSSN----PCSETEALLFIANNK-S----LR HLLKHPLLA-----------SFLYLK--------------------------------------YL------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------R------------------- ----------------IRHV-----------------LYVNFFLYLVYFFMLISYI-------------WVI TS------------------------------------------------EAELE----------------- -A-EE-----------LRSK-------N---LT-------------SIKPKQDD------------------ ------------------------------------------------------------------------ -DV-DVAEEENGMFANLEN----------------------------------------------------- -------HPIHSALLFAALIYMI-----V---------RELL-QF--IS----------------------- SPLHYI-G----------SPENWIEITL----------------------IGLTGGLLLGGGV--------- ----------------------------------------------------------KLG----SLAALLS TWELVILMS----------------------------------------------QHPRMST--DIEMFKTV TL-NFARFLFLYVFLILAF--AFAFFVLF----------------------RD------------------- PENEN-------------------------------------------FVQ-P------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------PLA----- ---------------------LFKTIIMLTGEFD--SSDLPFS----------------------------- ----------------------------------------HF---PVLSR----LVFCGFIFLIVIILLNLL NGLAVNDTAEILSQAELVCLISRARLV------------------------AYAERIAVGQPFVPKTRLCCF INY--LP-------------CQSLTTG-----------------PV-----------RFMAR---------- --RILLFPRY-----------------------------------------------LPH-FTLSV------ --------------------------KPLKNYEITL--HGR----------------P-------------- -------FTGSRCSTLKMDPVV-AQRAKE---------------------------------ILEAKGRVSS E----------------------------------------------------------------------- -------------------------------------DKILE------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------EIET---------------------------------- ------------------------------------------------------------------MRRR-- -----------------FDGIEAMVR-----------------EI--------------------------- ------------------------------------------RETVRNNNLN-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------AED------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >NvPyr/1-939 -----------------------------------------------------MSSS----RGKAGF----L DKLA-------------------------------------------------------------------- ------------------------------------------------------------------------ --GRSKSGGRAGN----------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------DETK-------- -------------------------------------------DQPPTIF---------------------I DCEDEEQIWMD---NMDSD----------------------------------------------------- --SIS--SE-GSSGSA-------------------------------------------------------- ---------------------------------------------V--CLR--------------------- ---------------------------------------------------HRP------------------ ----------SSHQ---------------------------------------------------------- ------------------------------------------------------------------------ -QLWDKEEV----------------------------------ILSLTN----------------------- -------LPAGEAA----L--AVLPSLCGEP-LDQV-ADEIGDKTV----------SQSA-D--------LS ALIPRFAN------GCI---------------------R-KASL-IAENESALS-S-TPADLI--------- ----------------------------------------ANWPNTCLLVACWIGHSELAKLLLDK-GAQV- ---SYRD-A--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------DGR--------------------------------------------------------- TALHL---------------------AASIG-----SVKITELLLK--------------------HG-AD- ---------PCEWDF---NRK--------------------------------------------------- -----------------------------------CTAL--HCAAAAGDVDTVQCLIR-------------- --------------------------------------------AGA--DVNAGLS-------------GKS PLHYAVQNNA-------------------------------------------------------------- ------E------SCVEALLQ-----------------------------AGA------SP----------- -----------------------------NN-P-----QVYTE-------TPLHVAAG-------------- ---------LGSEECM--------KLLLSH-GAD-VRVQF-------------------------------- ------------------------------------------------------------------------ ------GAARSTPL--------HLAAE---------EGSPECTR---------------------------- ------LLL---------EAGALPDANN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---SRGQTAL--------------------------HLAALA----Q------------------------S SETLD--------------------------------ILIAG-G--ADVN-AEDD-------NGR------- --------------------------------------SPLHAAVAK----------AVRGSEL-VRALIQA GAV------------------------------------------VNRPDK-F------------------- --------------------------GYT------------------------------------------- --------------------------------------------------------------------ALHI AA------------------LNESS---------PIVILLLTKGADVTA-RTK------------------- -GGVSALSFI-------------------------------------------------------------- -------------------------------IR--RTP-DVLPRFVGRLDQAISLHDH--------ELGDVD CELRLDFRP--------------------------------------------------------------- LVPG---------------------------------------------GRGESDLMLCLVDVG-Q-----R HVLKHPLCE-----------SFLHLK--------------------------------------WL------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------K------------------- ----------------IRKF-----------------FLFSLIFHSIFVAIFTGYI-------------ACT F-------------------------------------------------LWQL------------------ ----------------------------------------------------PKL----------------- ------------------------------------------------------------------------ -------GGVLF------------------------------------------------------------ -----------------WFVLLFTVLLAS---------KEIF-QV--AH----------------------- GIWVYA-K----------GWENALQWSV----------------------ILTSGMVLI------------- ------------KP-----------------------------VA-DWQH--------HVA----AVGILLV WVELMMIVG----------------------------------------------RFPTFGL--YVQMFTQV AI-NFFKFLGAYLCLIVGF--SLGFSVMH----------------------KN------------------- --YKS-------------------------------------------FQN-P------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------LVG----- ---------------------LLKTIIMLSGELE--FEDVFFD----------------------------- -------E---AAPVL-------------------------Y---AGTSH----LMWLAFVILVTVILANLM MGLAVSDIQELRQCAGLDRLIRRAELV------------------------AHLESLLFSKLLDYA------ ------P------------------------------------RRIV----------KACRS---------- --SA-LLL----------------------------HLPHHCA--------------------IHI------ --------------------------RPNDPREKR------------------------------------- -----------------LPREL-IKSI--------YRL-------------------------VSER-KTKS KSC----------------------------------------------------GNNASIRSLNGNGYSSH -------------------------RL----------SRLYS--NSS------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------FSE--------------------FNRQQ---------- ---------------------------------------------------------------LSDLAME-- ------------------------LK-----------------KC--------------------------- ------------------------------------------SLTIGARLN--------------------- ------------------------------------------------------------------------ -----------ALTSKVEA----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------I--------------------------------------------------- ----------------------------------------------------------------------AK EID--------------------------------------------------------------------- ---------------------------VATQL--Q------------------------------------- ------------------E----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >NvTRPM/1-1679 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------MAIGSVIC--------------------- ----------------------------------------------------------GANTPKTKRK---- ------------------------------------------------------------------------ ------------------------------------------------------------------------ KTKTTERS---------------------------------------------------------------- ----------------------------------------------WIEATFQKRE----------CTK--- ---------------------------------------------FIPSAK-DEH----------------- --RCCCGHS-YTHHCGT-GADVQSFASS----------------------------------------AAAE AERDEWSPGKNT---------------------------------------------------KHCPTDAYG TIEFQGLPHP--------------------------------TKAQYVR----------------------- ------------------LAHDTKPEPIVQL-LCRE--------WNLGLPKLLITVHGGR-S-----NFELQ PTLKK---------------------------------VLRKGLLKAAKTT--------------------- -----------------------------------GAWIFTGGTNTGV---------------TRQVGDAL- ---LLERSQ--------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------RQG---------------- ------------------------------------------------------------------------ ----------------------RVVSIGI------------------------------------------- ----------------------------------------APWG---------------------------- --------ILEKSHEL-------------IG-----RG---------------------------------- REVPY----DSLA--------------SPWSKFAVLNNRHAYFLLVDNG-------------TGGRYG-AE- ---------IVLRRKL--EK-------------YISNLKLQPYTHS-------------------------- -----------------------------------SIPV--VALVIEGGTNTIRSVLE--YVTDEP------ -----------------------------------------------PVPVVVCDG-----------S-GRA ADLIAFMHKYASENESE--EEEGPLESMRDHLLDTIKRTFKVSPEQANQ-------------LYSELLQ--- --CVRRK------HLITVFRIS---------------------------QDQP-----QEL----------- -----------------------------DQ-T-I--------------LTALFKSQQ-------------- ---------LSPAE----------QLSL-------------------------------------------- ------------------------------------------------------------------------ ------------AL------------------------IWNRVD---------------------------- ------IA------------RSEIFVYGQKWP---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------PGAL----------------------EQSMMQALQH----D------------------------R IDFVK--------------------------------LLLEN-G--VSMRKFLSI--------PRL------ --------------------------------------EELYNT-------------KEGPSNT-LGYILRD --------------------VRP-HIPRGYMYTLHDIGLVINKLMGGAYRSQYT-----------RKEFRFL YTRVMKRSGGYQQ-------HHAHRNSCAIA-------------------LNSRSFSGS--------GGKS- --TMSLL-----------------------------------AETIPATQETAL----------FD-YPYNE LLIWSV--------------LTKRQ---------HMALLMWQHGEEALA----------------------- -KALVALKLYKAMAHEAAED---------------------------------------------------- ----------------------DLETEVYDELK--GYGKEFENIALELLDYCYRQDDD-------------Q TQQLLTSELK-------------------------------------------------------------- -------------------------------------------------NWSGQTCLSLAVTAN-H-----R ALLAHPCSQ-----------IILADL--------------------------------------WM------ ----------------GGLR--TRKSTNFKVI------LGLFCPVYIT--QLEFK----------------- -SREELQLMPQTAEEHLI------------------------ALEDENEDSE-------------------- -----SEHG-----------------------------TPTGPDVEALIGNEHGL--GSAAPKE-------- TIVHENGKV------------------------LTDNDEGNHRAYGILS--------------EYYDNKNSR PLRLK-----------KKLY--------EFYTAPITKFWANAIAYVIFLLLFSYSI-------------LVR MGD--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------VPSWAEIYAIAYICTMGC---------EKVR-EI--ATS----EPV-----------ALSH KFSVWA-W----------NMWNPCDAAA-------------------IIFFIIGLVLRLR------------ -------------------------------------------------PST-FDVGRTIY----CVDCMYW YLRMLNILG----------------------------------------------VNKYLGP--LVTMMGKM VK-NMIYFVVLLLVVLMSF--GVARQAILNPN-------------------AE------------------- -------------------------------------------PNWRIIRD--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------V----- ---------------------FMEPYFMLYGEVY--ADQID---------------PDCDN----------- -------NPGMEP-CLPGR---------------------------WITP----AAMSVYLLVANILLINLL IAVFNNIFIEVNAVAHQVWMFQRFTVV------------------------MEYEQK--------------- ---PVLP-------PP--------------------LIVVSHLYLIIR----------YILR-------YVT QGRL----------------QS-G---------ETSDNGLKLFLEA------DDKERLYDFEEDCVEGYFR- -------------------------EQELKLQMST------------------------------------- ------------EERVKVTTER-VENMHQKIEDIDKKESNQSS----------------SLQTVEFRIRKLE ELNEQTLAHLGVIHRFMATYMPVGGGGAGGGGGPGNENSSST------EALRHLDVELIRPRRVSERSE--- --------------------------A-----------GMSE--SDSH--AQLPCIPLRRKKLIRAMT---- -----DAAY-----MNMAAG----GLVGQQQ-HREQLQ------EQMEQDEAT-------DLNRAVEAM--- --------------------------------------VGDNLS--------------------RNGSSVSG EI-----------------------------ATLQDESKENTS-------------HDESD-------LS-- ----KAVGEL-KDLKAEKSDD--------------------------------------------------- ------------------------------RD-----TSGDVTATT------------------------DS -----------------------------------------RQDSVEKSS---------------------- ------------------------------------------------------------------------ -------------RQNSRT-RSESL--ADDAAA--------------------------------------- ---------AAAIA-ASVSGVVVPSASFQRGV-T-WA-----------------EPRVA------------- ------------------------------------------------------------------------ ----------------------------------VIQSSG-----SSNS----------RSLLLA------- -------------MRAEYTSITDE---------------------------------------------LES YC-GLLSPPRTP------------PVSPP--------PCRVRSVSERSNQN---PVEIAWQIEN----EHLR DAEECDYQQMEDLIQRRY-------------------HISDEEDSSHDD-------PAVVNT------TSFF IS---------SEHHP------R---LRRA-----SAID-----------------------------EDTT TRRRCHRS-------P-PSINV-------------------------------------------------- ------------------------------------------------------------------------ --------------------------------------------------TREIEQTL-------------- ----------------------------------------------ARPAATRDSAESDP------------ ------------------------------------------------------------------------ ---------------------------------------------NDKG-MSGVAAPASETMC--------- >NvTRPML/1-617 ------------------------------------------------------------------------ --MA-------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------RSISARPPSAR------ ------------------------------------------------------------------------ -----------------------------------------------------------------------I -------DLVEKFV---------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------W-------------APAPFQ--- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------P--------------------------------- PSTG-------------------------------------------------------------------- -------------------------------FGSRLTTTPVPTTYM-------------------------- -------------------------------------------------EERMRRRLR-------------- ---FF--------------------------------------------FMNPIEKWQ---------AKSRF PYKFVV------------------------------------------------------------------ -------------QVIKIVLV--------------------------------------------------- --------------------------------T-V---------------QLCLFAHNN------------- ---------YTHVNYTWDNRITFSHLFLRGWDAT-------------------------------------- ------------QE---------------------------------------------------------- -VPAYPPATGPLAL-------------------YKQDEFYETID---------------------------- ------YALKGYYNIGN-AIGSYSY----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ TAEDNSVGVVVLCLHHYEEG----------------IIFAYN----E---------------SYIFN----S -KIVEKC--------INIT------KQEEETVTSKL-LMQQN-K--IPV----NF----------------- --------------------------------------SALVKAE--------------------LKFDVKT VNLKA-------------------------------------AGPITPPDC--------------------- ------------------------------------------------------------------------ -------------------------------------------------------------------YRFRI KIL-----------------MDNKD----------------------------------------------- FDGQMLLSLD-------------------------------------------------------------- -------------------------------------------AEPVRLV-CK-DTQYIT-----DNQIESA LRTLLNLLVI-------------------------------------------------------------- -------------------FICSL-----------------------------------------SLGLCSR AIYRAQLLKFETM-------NFFKKVYGTSLSLEGRLEFLNL----------------------WY------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------VMIIINDLLIIM---G-----SAIKQQI--------------------------- ERKQYG-N----------DHWNLCSIFL-------------------------------------------- -----------------------------------------------------------------GTGNLLV WFGVLRYLG----------------------------------------------FFKTYNV--VILTLKKA AP-KVARFLICAILIYAGF--TFCGWLVLGPYH--------------------------------------- --------------------------MK--------------------FRS-L------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------ATT----- ---------------------SECLFALINGDDM--FATFSITSF-K------------------------- ---------------------------------------SPML--WWYSR----IYLYTFISLYIYVVLSLF ISVIMDAYDTIK---------------------------------------VYYRDGF-------------- ------P---------------------------------------------KNDLQSFV------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------SVC-TDEASS------------------------------------------- ------------------------------------------------------------------------ -------------------------GV-----------------YRDEA----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------DDEP---------------------- ------------------------------------------------------------------------ -----------ILGGLFGR----------------------------------------------------- ------------------------------------------------------------------------ ------------ICCCSQR----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------KNKPHS DFS--------------------------------------------------------------------- ------------------------------------------------------------------------ ---------------P-------------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------------------LTNSNSTSST------------- ---------------------------------------------------IDSVQVCPSAICI-------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ >NvWtrw/1-1033 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------MAE------------------------------ --------------------------------------------------------PSS-EEPS-------- -------------------------------------------PLDK---------VFPA------------ ---------------------------------------------------------SPN------------ --SAVHNNNTT------------------------------------------------------------- --------------------------------------TV-----NHNNTRNRRVQ-L-------------E RS----SSSIQ--------------FPASAMALA---------------HKSKT------------------ -----------SSN-----------------LLTGRCLSSSN----------------------------CS STTRR----------VSLPSTEDPT------------------------WVGEDRCMEY-----GTPPPIEE PHCYSMCLS----------------------------------ESSFSE----------------------- -------ESSCAVQ----INRDYLKGLLVEH-TRTL-G-------------------CRL-L--------VV EELEA------------------------------------GKLDLASADKYLEGC--KKPQ---------- ------------------------------------------ELNALLLYASFLGFGELIPIVHNH-GADL- ---NHSEPE--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------LGM--------------------------------------------------------- TALHL---------------------CAFSN-----CLSGVRYLL----------------------G-HN- ---------VHVG-S---KKA--------------------------------------------------- -----------------------------------HTPY--HFAAFGNAIDVAKFFAQ-------------- --------------------------------------------LGW--SQESP------LGE-------ET VLHAAARNNA-------------------------------------------------------------- ------L------DVLRLLAP-----------------------------KNP------TL----------- -----------------------------NR-L-----DSAGY-------AAIHYAAE-------------- ---------RGDSGCL--------KVLLAA-GCL-VNVST-------------------------------- ------------------------------------------------------------------------ -------RKGETAL--------HLSAE---------AGCAESLE---------------------------- ------LLL---------AKGANPAVRN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---RRGQTAL--------------------------HLAART----H------------------------S LECVE--------------------------------ALLQH-SR-SEPN-AEDH-------DGR------- --------------------------------------TPLHVALGR----------SLLAYDV-TEMLISW KAQ------------------------------------------VNKPDK-Y------------------- --------------------------GYT------------------------------------------- --------------------------------------------------------------------PLHV AA------------------LNELS---------QCVDILIQHGADLSA-KTK------------------- -GGTSALSII-------------------------------------------------------------- -------------------------------LR--KTP-SSLNCFKQRLDASISMHQHG-------SA-AGE VELRLDFHP--------------------------------------------------------------- LLQH--------------------------------------------QQQGEIGYLGTFVKEG-Y-----K EILEHPLCQ-----------SFLHLK--------------------------------------WQ------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------K------------------- ----------------IRKY-----------------YVGRLLFYLLYVLVLTAWV-------------ITA L-------------------------------------------------AHNCY----------------- -NE-----------SHGQLD-------N---SS---R----------------PLC---------------- ------------------------------------------------------------------------ ----ANSTGLNGFLYRHPV----------------------------------VLE---------------- --------------VEWYALVVLTVLEGL---------RKLM-GILTYS----------------------- TVRQFF-T----------QAENMVEW-C----------------------VIVSVFATSF------------ ----------VYTG-----------------R-----------TY-TWQS--------HVG----AFAVLCG WSNLMLMIG----------------------------------------------QLPMFGA--YVAMFTSV QA-QVFKLLLAYACLLVGF--TASFCVIF----------------------PR------------------- --SKS-------------------------------------------FSS-P------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------HTG----- ---------------------LIKVLVMMTGELD--FEELFFPGEEE------------GGRP--------- ------VDVGGTSWIL-------------------------L---QVSAQ----LSFVLFLLFVTIVLMNLL VGIAVHDIKGLQKTAGLAKLVRQTKLI------------------------CDLETALFLGLL--------- ------P------------------------------------QCLM----------KVLRW---------- --TA-LVL----------------------------PSPLKAV--------------------LTV------ --------------------------RPLNPREKR------------------------------------- -----------------LPRDV-LAGA--------YKV-------------------------ARER-K--- --------------------------------GNLLNS-------------TLSSKRSNN--STIYGYQKFD LNASVRRRT----------------NM----NEEP----------AT------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------TLE--------------------EAA------------ -----------------------------------------------------------------RLKEE-- ------------------------VA-----------------EL--------------------------- ------------------------------------------RKICESNNL--------------------- ------------------------------------------------------------------------ -----------LIQELVKSFT-FGS----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------IASDYRKRRKVI----------------------------------------- ---------------------------------------------------------YMILVIMS-----RK NKR--------------------------------------------------------------------- ---------------------------NL------------------------------------------- ------------------------------------------------------------------------ ------------------RETSV------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >NvXP_001604491.1/1-1089 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------M-------------------- -------------------------------------------------VS--------------------- ----------SASEKEM-EA---------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------APE---------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------KKR------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------GLS---------------- ------------------------------------------------------------------------ ---------------------HYAFHLP-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------RPLNIE--EK---------------------------------------------------- -------------------------------------KY--LLSVERGDLPNVRRILQ--AARKP------- --------------------------------------------INKSIDVNCVDS-----------L-GRG ALTLAI------------------------------------------------------------------ --EAENL------EMLELLI-V------------------------------------MGV----------- -----------------------------ET-K-----------------DALLHAIN-------------- ---------QEFVEAV--------ELLLEH------------------------------------------ ------------EE---------------------------------------------------------- ------------PA--------GKAEIVH---------SWQKVD---------------------------- ------P-------------SLARYAPDM------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------TPL--------------------------ILAAQK----N------------------------N YEILK--------------------------------LLLDR-G--ATLPMPHDI----------------- ------------------------------------------KC------SCDDCVRA-ATGDP-LRLSSTR ---------------------------------------------IAEYRALAS------------------ ------------------------------------------------------------------------ PSLIALSSP----------------------------------------------------------DPL-- ------------------------------------------------------------------------ ---MTAFQLSWELRGLAL------------------------------------------------------ -----------------------AEPESCAEYL--RLRKQVEKFAVDLLQQTRSSSE--------------- LNTILNY-----------------------------------------D----------------------- --PDD-HS-------------------------------AEPT------K--QLARLEQAIRYR-Q-----K KFVAHPHVQ-----------QLLAAI--------------------------------------WY------ ----------------EGVPGFRRMGAIQRAWIIVK--TALLFPFYCT--IYFFTP---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------NTSTG--------HTMRRPFMKFLVHASSYLFFLLVLILVS--------------QR FEEELL--------------------------------------------SW--F----------------- ---------------------------G-------------------------------------------- ------------------------------------------------------------------------ ------TDYDRQQLEEGFS----------------------------------------------------- ------KQRGLGPSFLECIVVIYVLGFIL---------EETR-EV--YVD---------------------- GLRAYL-R----------DLWNFIDFTR-------------------NALYVATVILRVAAYIQQSAEINQD SAAA-------TIP-----------------RE-------------RWPDFDPQLIAEGLF----AAANIFS ALKLVHLFS----------------------------------------------INPHLGP--LQISLGRM VI-DIVKFFFIYTLVLFAF--ACGLNQLLWYFAELERKKCYS-D--------------IDEPTWD------- SASDS------------------------------------C-IRWRRFSS-L------------------- --------------------------------------------FE-------------------------- ------------------------------------------------------------------T----- ---------------------CQSLFWASFGGVG--IDSFE------------------------------- ---------------LTGI--------------------KSYT--RFWGL----LMFGSYSVINVIVLLNLL IAMMSNSYAIIEEHADTEWKFARTKLW------------------------MSYFEE--------------- --GNTLP-------PP--------------------FNILPHPKLLM----------------------RCC GVQR----------------KSMS-----------KRSSIRRR-----------AREQLSRYGSVMKALIW- --------------------------RYVVNAHSE------------------------------------- ------------HEMEPVTEDD-IHELKSDFSSWRCELLEIL------------------------KRNGMD TGGADT-----------------------------SNST------------VLGKKMRVWER---------- -------------------------RL------------MKD--FQ-----------------VASLAD--- ------------------------------------------DPIEEMQHLEN------------------- ----------------------------------------P-------------------------PE---- ----------------------------------NEEIAAKWR--------------RIAR----------- ---------------------------------------------------------------LAVLKSAEH ----------------------------------------RWTQV-----------------------IDNT V-TK--SQI---GR---------------------------SNNRVSLRNQAN------------------- ------------------------------------------------------------------------ -----------LKRVMEEARRLSLT--SPPPP---------------------------------------- -----------LTP---------IK-LPDT-----INPTNILRVLK-------------------------- ------------------------------------------------------------------------ -------------------------DDDDF--NH-FPMD--------------------VSPAISMTMAM-- TQEPAS----------LTDNVRT-------KNDSSALNYVNER---Y---------------------QGRS ASPR----PLAPIR------------TSP------PRVVKRKPQAPPPG----------HALPR----SPAS ------------------------------NILSVDNLV--------------------------------- --------------------------VPGDGS--SS-N--------------------------VVR----- ---------------P-RPKSP-RR----------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------VPEVA-------------- ----------------------------------------------ISPVTP-------------------- ----------------------EQKASNCGRGFVKIEPRSPRVAAAN------------------------- ----------KSPR----------------------------------RN-------------GGWL----- >NvXP_001604587.1/1-1313 ------------------------------------------------------------------------ --MD-------------------------------------------------------------------- ------------------------------------------------------------------------ --------FKEDE---------------------------------LSEDEIHG----------PDT----- --------------------------------QSAGEDEDQFARGSGS------------------------ --------------------------------------------------------PGG-------GSAD-- ---------------------------------------------EGSAEP--------------------- -----------------------------------------------------------------SASA-TA AGVASNQS---------------------------------------------------------------- ----------------------------------------------TVAVRM-------------------- -------------------------------------------------AE--------------------- ----------NRRPRGF-LAGPARHPPP-------------------------------------------- PLPLQHTHVNFD---------------------------------------------------PEAPP---- ------------------------------------------------------------------------ ------------------TPTSNQPLHGG-------------------GPGLLHP--QAY-P-----QMSL- -------------------------------------------LEKP------------------------- ------------------------------------------------------------------------ ----EIDKKVK------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------RHS---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------IHG---------------------------- --------MME-------------------------DE---------------------------------- NVIR------------------------PH---------------------------------------QE- ---------MIRLSTD--DR---------------------------------------------------- -------------------------------------KF--LLAVERGDVAGVRKILT--ENKEK------- ------------------------------------------------ININCVDP-----------L-GRS ALLMAI------------------------------------------------------------------ --DNENL------EMVELLI-N------------------------------------YKV----------- -----------------------------DT-K-----------------DALLHAIS-------------- ---------EEFVEAV--------ERLLDH------------------------------------------ ------------EE---------------------------------------------------------- ------------EF--------HRNGEPH---------SWEALP---------------------------- ------P-------------DTATFTPDI------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------TPL--------------------------ILSAHR----D------------------------N FEITK--------------------------------ILLDR-G--STLPMPHDV----------------- ------------------------------------------RC------GCDECVTS-RLEDS-LRHSRSR ---------------------------------------------INAYRALAS------------------ ------------------------------------------------------------------------ PSLIALSSK----------------------------------------------------------DPI-- ------------------------------------------------------------------------ ---LTAFELSWELRRLSF------------------------------------------------------ -----------------------LEHEFKCEYQ--ELRRQCQDFATALLDHTRSSYE--------------- LEVLLNH-----------------------------------------D----------------------- --PTG-PA-------------------------------FEHG------ERMHLNRLKLAVKLR-Q-----K KFVAHPNVQ-----------QLLASI--------------------------------------WY------ ----------------EGLPGFRRKNMVLQALEIVR--IGILFPFFSV--AYIIAP---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------HSVIG--------QTMRKPFIKFICHSASYFTFLFMLILAS--------------QR IESVIG--------------------------------------------VW--T----------------- ---------------------------G-------------------------------------------- ------------------------------------------------------------------------ ------RD-ISE--HEIEP----------------------------------------------------- ------TKRGAAPTLVEWFILAWVSGLIW---------SEVK-QL--WDV---------------------- GLEEYV-N----------DMWNVIDFVT-------------------NSLYVATVALRVVAYYRVQK---EN EGSD----IIVDLQ-----------------RE-------------QWDTWDPMLISEGLF----SAANIFS SLKLVYIFS----------------------------------------------VNPHLGP--LQVSLSRM VM-DIMKFFFLYVLVLFAF--SCGLNQLLWYYADMEKKRCPTAMPHLPP--NAN---------IT------- QDPNA------------------------------------C-IVWRRFAN-L------------------- --------------------------------------------FE-------------------------- ------------------------------------------------------------------T----- ---------------------TQTLFWAVFGLVD--LESFE------------------------------- ---------------LDGI--------------------KVFT--RFWGM----LMFGTYSVINIVVLLNLL IAMMNHSYQLISERADIEWKFARSKLW------------------------ISYFEE--------------- --GGTVP-------PP--------------------FNIIPTPKSIWY-------ITQWIYR-------KLC GHSR----------------AAKK----------EHMRTIR-------------ASERDDRYRAIMKNLVR- --------------------------RYVTVEQRK------------------------------------- ------------TENEGVTEDD-VNEIKQDISAFRCELINIL------------------------QKSGMA TEHTSG-----------------------------TGTG------------VGGKKNRQKER---------- -------------------------RL------------MKG--LGGL------------DGPLGPQPSGSG PLPPVAEAT---------------------------------ASLRDHQHQTSGHHPHD-IFSSTLSGIFR- ----------------------------------------PGTTP------------------KRNPH---- -----------------------------------HTSTNSVP-----------------G----------- ---------------------------------------------------------------LASCQRQSR ---------------DSRGSSRKR----------------RWGTL-----------------------IEAA K-AGRVSRLI--GR---------------------------SRSQDSVY----------------------- ------------------------------------------------------------------------ ------------SPASEDGESRSDG--SSDSKS--------------------------------------- ---------SLDVP---------------------------------------------------------- ------------------------------------------------------------------------ ------------------------SQDSHP---H-HPHHQ-----SHHPHSSHHHQQHQHHHQHHYALG--- ---PALA------------ALRRKRKKFSASRASTP---------AM---------------------TMSS GNNS----ACTSST------------LES-----VMQPIASALVSRVSK---------K-QLQR-ASSVPTR SPE--------------------------------------------------------------------- --------------------------LALHQV--V------------------------------AP----- ---------------P-RRHET-TQSQQPSL---------------------------------------DD T----------PSSNNGSKEQGGVTASAAAV-------AAM------------------------------- --------------------------------------------------TSS--AVD-------------- ----------------------------------------------LTPSTTEESVLSASTAIVTAVKR--- ------------------------NGSAGQQQQQQQQQQ--------------KLPPG-------------- ----------IEPISGHDG-----------------------------------------TASTGWL----- >NvXP_001605329.1/1-1082 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------M-------------------- -------------------------------------------------NA--------------------- ----------SESQQNL-LTN--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------EAKPA------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------STS---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------Q---------------------------------- QWLS------------------------PP---------------------------------------AD- ----------YVLGPV--EK---------------------------------------------------- -------------------------------------HF--LLSAERGDCATVRRLLE--ENKD-------- --------------------------------------------HPEILNIDCVDP-----------L-NRS ALIAAI------------------------------------------------------------------ --ENENI------DLILLLL-E------------------------------------LGI----------- -----------------------------SV-K-----------------DALLHAIK-------------- ---------EEYVEAV--------EILLEH------------------------------------------ ------------EE---------------------------------------------------------- ------------KI--------HQPGQPY---------SWEAVD---------------------------- ------R-------------SASNFTPDI------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------TPL--------------------------ILAAHK----N------------------------N YEILK--------------------------------ILLDR-G--ATLPTPHDV----------------- ------------------------------------------RC------GCDECVSS-SEQDS-LRHSQSR ---------------------------------------------INAYRALTS------------------ ------------------------------------------------------------------------ SSLIALSSR----------------------------------------------------------DPL-- ------------------------------------------------------------------------ ---LTAFELSWELRRLSR------------------------------------------------------ -----------------------MEQEFRSEYN--EMRENVQVFATSLLDHARTSHE--------------- LEVMLNY-----------------------------------------N----------------------- --PSG-EN-------------------------------WEPG------ERQTLERLKLAIKYK-Q-----K QFVAHPNVQ-----------QLLAAI--------------------------------------WY------ ----------------DGLPGFRRLSMMGQLLEVGK--LGAQFPVYST--IYMLSP---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------NSPKA--------LFMKKPFVKFICHSSSYAVFLMLLGAAS--------------QR IEYLAI--------------------------------------------EL--F----------------- ---------------------------G-------------------------------------------- ------------------------------------------------------------------------ ------NAWMRQILAGWKR----------------------------------------------------- ------RERGSIPGFVESGVIIYVFSLVV---------GEIR-SL--WAD---------------------- GLLEYV-S----------DLWNIVDFVQ-------------------NVFYVIWITMRATSWLVVMREYWA- GEDP-------WYP-----------------RD-------------HWDDFEPMLLSEGAF----AAGMIFS FLKLVHIFS----------------------------------------------VNPHLGP--LQISLGRM II-DIIKFFFIYTLVLFAF--GCGMNQLLWYYADLEKNKCYHLP-------N-------GLPDFD------- NNEKA------------------------------------C-ATWRRFAN-L------------------- --------------------------------------------FE-------------------------- ------------------------------------------------------------------T----- ---------------------SQSLFWASFGMVD--LMSFD------------------------------- ---------------LTGI--------------------KSFT--RFWAL----LMFGSYSVINIIVLLNML IAMMSNSYQIISERADTEWKFARSHLW------------------------MSYFED--------------- --GDTVP-------PP--------------------FNMIPTAKTFD----------------------RIV KCGK----------------S------------GRPTRSVIKK----------SREKAKERHDTVMRLLIR- --------------------------RYVTAEQSK------------------------------------- ------------TDDFGITEDD-VMEIRQDISTLRYELIDIL------------------------RTNGMQ TPNVDK-----------------------------GDTSL-----------S-GKKGRVMER---------- -------------------------RL------------QKD--FQ-----------------IGIVEG--- ------------------------------------------------------------IVNSVI------ ------------------------------------------------------------------QN---- ----------------------------------EKESKDVFS--------------QIAK----------- ---------------------------------------------------------------AIGRKSSGG --------------------SKKK----------------DWNAV--------------------------V R-QNTVARDPI-GS---------------------------SNEAVDKQHRRS------------------- ------------------------------------------------------------------------ -----------LRRHLQHGNSL-LE--SLDPQR--------------------------------------- ---------LLEYN---------PN-LVEV------SATTRVAYAK------FM---LRRPA---------- -------------------------------AVKE---------AAE---------GE-------------- --------------------EAP------------------------------------------------- ---------------ADGEG--------------------KT--------------------------SKRS SQRVAIIDPAKPG-------------EKP-----PDRPPPATRALGTLS---------KKSL----IKAASS ------------------------------------------------------------------------ -----------------------------------------------------------------DK----- ---------------P-EAGKS-SLEA--------------------------------------------- -----------KPSQEQRGGPSPIPEEP-----HEESKAPI------------------------------- --------------------------------------------------GSRAASLK-------------- ----------------------------------------------KQPSAAASEP---------------- ------------------------------------------------------------------------ ----------KKP-TADEGPT------------------------TKARGRSKA----TGQIVGGWI----- >Parg11047818_Pain1/1-925 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------MA---------------- ---------------------------------------------GY--LSLRTME---------------- ------------------------------------------------------------------------ ---------------------------------------------------------------GNGVAMQGG -------------------------------GSPGGD-----DEDHYKQE---------------------- --------------------------------MLLS-VRT-----------------GDG-E-------KLR CALKHL----------------------------------PQKS-IN------------------------- ------------------------------------------------Y-------------IFPH------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------PDSA--------------------------------------------------------- TALHI---------------------AVQNNS-----DDLVEALLK--------------------AA-AD- ---------PNARDHR--GKK--------------------------------------------------- -----------------------------------YCPL--HYAAQNGNVEILKALLK-------------- --------------------------------------------AGA--DPNAKEG-----------EFGRT SLHILAT----------------------------------------------------------RW-K--- -NNEDN----FK-ACLDALLS-----------------------------CKK-----IKI----------- -----------------------------DT-M-----DSSKA-------SPLYMAAT-------------- ---------KSWEYMA--------HQMILK-GAN-IDSAVGN--------------KTAADIIRKKLPGLL- -------------EKIDFSVIEKPQRYYSDELYDAMIDHDLELFKEILTDISNSQEKSKA------------ -SILEEDHGEYTLL--------QYACD---------NGMSDFVE---------------------------- ------ELL---------KNGANPTLRD-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --ETSKMSPI--------------------------LYASRN----G------------------------Y YKVVE--------------------------------LLVGT----------MRE-------RGD------- ---LEKGI---------------------LKQTDLRKETPLHKAVKREY-PLKT--EGINYYRC-LQLLLDK KRY----------------------------------------LDIDAQDE-F------------------- --------------------------GNT------------------------------------------- --------------------------------------------------------------------PLHY AVL------------------CDDQ---------SFVRILLLNGAHLGI-RNK------------------- -FGTLAITRIQ------------------------------------------------------------- -----------------------------------------ASVLEEVLNDCIKHK---------NNVADRD FEIILHYSM--------------------------------------------------------------- LAP----------------------------------AQASQQ--------PETECLRFLSGSR-T----HR RLLLHPIID-----------TFLFLK--------------------------------------WQ------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------R------------------- ----------------IRQY-----------------YFFNIFAYTTFLILLTAYI-------------LIY QG------------------------------------------------TFTPS----------------- -A-EE------------TGL-------N---TN-------------ET------------------------ ------------------------------------------------------------------------ -NP-NSTASDDKMVREMLK----------------------------------------------------- -------ENNAVKYILKGLISLFALYIVV---------RETI-QF--LV----------------------- SWKLYI-C----------RLENWLEISI----------------------VLLTAALLFIPMS--------- -------------------------------AE-------------PQQ---------SLS----AWLIIFS WIEFILLLG----------------------------------------------RHPYLAV--YITMFTTV TY-NFLKFIIMFSFMIVAF--SISFYLVF------------------------------------------- QVDEN-------------------------------------------FMT-Y------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------HQS----- ---------------------LLKTIAMTTGEIE--YTELPLS----------------------------- ----------------------------------------SF---PVSSH----LLFVLFVFLIVLVLMNLL NGLAVSDIQQIQQEAEIVSYSSRVELI------------------------SYIESVFLASPF--------- --QQIIPGP--------ITCCESG--ADDCFLMSCLDYPNPAMKLL-----------KWMGR---------- --RTLMFHSC-----------------------------------------------LRD-HRITV------ --------------------------YPNRG-------------DERWH----------------------- -------VC--DCHSFHLKEAQ-IEAAKD---------------------------------VVLEKEHAVA N----------------------------------------------------------------------- -------------------------------------HR--------------------------------- 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-------MII-------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----RAE----------------------------------------------------------H-----L DMLEGGIIQ-----------RLLEEK--------------------------------------WK------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------T------------------- ---------------FARNQ-----------------FLKRLAIMMLQLILLSVAV-------------YLR PCYCGP----------------------------------------------K------------------- -NMHT----------------------S---DPDVQ------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------KKLYD--------EFFDTD-- -----------VMSI---ARYCFEVGTLA---------GVIS-YV-VFQQ--------GEE-------IMNQ GLSSFM-R----------GLSGNSPKAI----------------------FLVSNLLITLCVPCRLVYFFSK -------------------------ERDPVMRV--------------IED--------ELL----AYAVAGS WFMLMFFAG----------------------------------------------ALKLTGP-FVVMIYKMI SG-DMFTFSIIYCIMLLGF--SEAFFFLY----------------------KSP------------------ IQDKD-----------------------------------------SKYAT-Y------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------RTT----- ---------------------WMALFHMTLGDYD--YAGMNQN----------------------------- ----------------------------------------IY---SAMSK----FVFLVFTIMLPIMLLNML IAMMGNTYSTVISMSEKEWVKAWAKIV------------------------IALERAISQEKAKDYLY---- --MYSLPLGGGGE------------------------GGEESLGVMVI---------KSKDK---------- -TKA----------------KQRKGA----------LSNWKRV------------------GRVTIDTLHRR GVSGEFLRREMWGLQTAAS-------TPAKGPAKKKGYGGL----------LGIDTGPATGEIMTSALDQAM FA-SDGEIVDP-DLMDGFG-AI-SGAIDQ-LAFT-HDLDF--------------------------SGDGVD DDPLKP----------------------------QM---KGPMQ---------------------------- ------------TAQVHKANHLAVAEK---KKK-KKQRETDG--YDNPAFLD-------DEELLLAAALG-- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------GAESDDS-----------------DTDMLE---------- ---------------------------------------------------------------SRRLAQP-- --------------RIIIR--AETE----------------------------------------VPPSTAT SATMPIAGGKA--------------------------LGPAASKDTKTSAKTTVT---------DVS----- ------------------------------LITRPRL----------------------------------- --------PSAKMRRIGSAR---------RTPARFA------------------------------------ MTFTEKY--DPVSK------------VATSTARK-MPDQPRAAEGT----PKVDES---------------- -------------------------------DLTEKNVEGGKEKV--------------------------- ---------------VNE--EASTHAAEA------------------------------------------- -------------------AVTD------------------------------------------------- -----------------------------------ADDGD-KWAEKK-------------------PRRSKN KVA------------------------------------PSSS----------------------------- ---------------------------SEEIE--RVADPRTQD-DLSVGL--------------QSG-SDTT ---------------R-EEVKA-------------------------------------------------- -------------KDKERPKTSVASQ---------------------------------------------- ----------------------------------------------------KMKKR--------------- --------------------------------------------------ATDNVGNMNS------------ ------------------------------------------------------------------------ ----------ILPWDNEDGDIK-------------------------------------------------- >Parg11322106_Nan/1-985 ------------------------------------------------------------------------ --MGNTESSV-------------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------------------TSG------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------VKAQA------- ------------------------------------------------------------------------ --------------------------------------------------------------NA-V------ ------------------------------------------------------------------------ -------------------------------------------------VEIYSLV---------------- ------------------------DLNGGGELVEL------------------------------------- --------MKKANKSK-------------------------------------------------------- ----EYSELDET------------------------------------------------------------ ------------------------------------------IRSKIPKY---------------------- --------------------------------MYNG---------------------GEG-K-----CLPIH RVVLRRNKER-------------------------------------PPSKEINPP---------------- --------------------------------------------------------------------KIL- -----PD----------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------EE----------------- --------------------------------------------SVA-GKY-----------VPGKMEPDRT T--------------------------------DHTTY-----------------------RY--------- ----------------------------------------VCWD---------------------------- ---------SKHVGAVG-------------------E----------------------------------- TVLHL-------------------------------------CVLN-------------------------- ------------------------------------------------------------------------ -----------------------------------ATSV--HND-------LAKRLIR-------------- ---HF---------------------------------------PNVINDIYLSDEYY-----------GEN VLHIAI------------------------------------------------------------------ --VNED------PAMVKFLLD-----------------------------NGA------NYHERCLGNFMCP EDQKASRSDS---------LDFEWVALCQQ--T-----NYEGYVY--WGEYPLSFAAC-------------- ---------LGQEECY--------RLILAK-GAN-------------------------------------- ------------PD---------------------------------------------------------- ----MQDTNGNTVT--------HMMVI---------YDKMDMFD---------------------------- ------MCF---------EAGATISLRN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---RQGLIPM--------------------------TLAAIL----A------------------------H RDIFF--------------------------------HILNI---------EREI-------YWQI------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------------KSLFD DSG--------------------------------------------------------------------- ---------------------------NPTPR--D------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------PIKGS-LKKV-------------------------------------------------- >Parg11606466_TRPML/1-725 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------MNPANH------ ------------------------------------------------------------------------ -----------------------------------------------------------------------G QCHIRRNSRDERVQ---------------------------------------------------------- -----------------------------------------------DDQSVPEQQ---------------- ---------------Q-------------------------------------------------------- --------LDVRQECKF------------------------------------------------------- -------------------------------------------------R-------------GGPQSGQ-- ------------------------------------------------------------------------ --------------------------------ATGE---------------------GEE-K---------- --------------------------------------LTQFRTQPQDT----------------------- ------------------------------------------------------------------------ ---PAGPRTLT------------------------------------------------------------- ------------------------------------------------------------------------ ----------------------------------------------------GQGR---------------- ------------------------------------------------------------------------ ----------------------RTSRLKA------------------------------RGRS--------- ----------------------------------------GSWS---------------------------- -------GVNESDDELE-----------KMAQVF-GQPP--------------------------------- PEIKV---------------------STALHN------------------------------GSSHYG---- -------SMTSSISSV-----GDY-------GRLDDSATTNTTNGLF------------------------- -----------------------------------NPEM---------TADRMRRRLK-------------- ---FF--------------------------------------------FMNPMEKWH---------ARRRF PWKLLL------------------------------------------------------------------ -------------QIFKIVVV--------------------------------------------------- --------------------------------T-A---------------QLCLFAQQR------------- ---------YNHVNYLWDTKVSFSHLFIKEWDTS-------------------------------------- ------------RE---------------------------------------------------------- -IQAYPPSNGPLAV-------------------YKKSVFYEYLE---------------------------- ------YAVIAYVRIPEEAIGTYDY----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ QYKNGSIVPPVLCATHYISG----------------HAFTTN----N---------------SYVID----D -NVTRTCLSIP-PSDVNVT-----------GWSAKT-YLEQH-N--FTF----DF----------------- --------------------------------------DLLLKVD--------------------FTFVLRT IKLRV-------------------------------------NLPFDTPEC--------------------- ------------------------------------------------------------------------ -------------------------------------------------------------------YHLTG SVI-----------------FDNGN----------------------------------------------- HDGQILVDLD-------------------------------------------------------------- -------------------------------------------VGARVLE-CVGSVQLAT-----ETRTLKV WRTIINVVSI-------------------------------------------------------------- -------------------LICIT-----------------------------------------SSCMCVR AIYRAQILKKATV-------LFFQRQYGRELSLDERMEFVNL----------------------WY------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------VLICVNDILIIF---G-----SLIKIGL--------------------------- ESKLFY-EEEERSYEGFLDTWNVCSLFL-------------------------------------------- -----------------------------------------------------------------GLGNLLV WFGCLRYLG----------------------------------------------FFATYNV--LILTIKKC IP-NVLRFSTCILMVFAGY--CLCGWLVLGPYN--------------------------------------- --------------------------LK--------------------FRS-F------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------SSS----- ---------------------MECLYSLINGDDM--FATFSSTSG-K------------------------- ---------------------------------------DPLV--WWFSR----IYLYSFISLFIYVILSLF IAIIMDAYETIK---------------------------------------NCYVDGF-------------- ------P---------------------------------------------LSYLMKFV------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------DEC-TEEPTS------------------------------------------- ------------------------------------------------------------------------ -------------------------GV-----------------FHDEG----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------DRT----------------------- ------------------------------------------------------------------------ ------------IHDIINS----------------------------------------------------- ------------------------------------------------------------------------ ------------LCCCVPV----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------QRHNSA ECE--------------------------------------------------------------------- ------------------------------------------------------------------------ ---------------P-------------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------------------LLT-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Parg1234957_TRPApw/1-962 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------------MAVT- ------------------------------------------------------------------------ -----GRKILRSIS----IE---------------E-SNP-----------------GT------------- ------------------------------------------------------------------------ --------------------------------------------------------------------PLL- ---RGLQPD--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------VRF--------------------------------------------------------- ASLLE---------------------ALKAR-----DVQEFREQLL--------------------RG-LP- ---------VNHRE-P-ALGN--------------------------------------------------- -----------------------------------KTPL--ICASEYGFLEAVVDLLS-------------- --------------------------------------------TGA--NVSTADD-----------A-GAT PLHM----------------------------------------------------------------A--- -AGGGHL------PIVRILLA-----------------------------HGA------HV----------- -----------------------------DP-L-----DTHAS-------TPLHYA---------------- -----------------------------A-RAD-NKD---------------------------------- -----------------------------------------PTSSSVV------------------------ ----------------------------------------DVVE---------------------------- ------VLL---------SAGARCGLRD-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---GEGRLPL--------------------------HNAATA----G------------------------S AKLIK--------------------------------VLTAG-PYKATVN-LKDN-------EGR------- --------------------------------------TPLHCAV-----------LGARSLEV-VEAVLQM GCN------------------------------------------IDTRDA-Q------------------- --------------------------GHT------------------------------------------- --------------------------------------------------------------------ALHL AAKRQV-------------NYIDEEFD------GACLELLLSHGASVAA-KNHEGYNALSLALLRTMWWGRP GARDQILHAVQLLLAKG------------------------------------------------------- ----------------------SCIQDGFAMWR--LVE-SFPSLVPVGLNRSVRANTSAHDSPH-------- --LRLDFDYG----------PLSVNAK-----------------------------------HLQEIHRQSP LVP--VS-----------------------------------ELPPPLLVDSEVAMLQYILWAGRK-----R LLL-HPLCH-----------SFLHLK--------------------------------------WF------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------K------------------- ----------------VRKY-----------------FLANVIFYFLFVLSLTAFL-------------LSS H-------------------------------------------------NCPEA----------------- ------------LITAHNST-------N---HS---AT---------------------------------- ------------------------------------------------------------------------ ------SNRTDT-VCHWAG--------------------------KEA----TVVG---------------- --------------LTWWCLVIFSACLNL---------REVI-QL--LQ----------------------- NPLIYI-H----------NLGNILDA-T----------------------LVFCVPQLLVGGS--------- -------ASETATN-----------------G-----EMAICCLA-VWQQ--------RVG----AIAIILA WVRLMLFTG----------------------------------------------QFPSCGV--YIVMFSTV AR-NVLKFLAMYVFVLVAF--ALGFHVLL----------------------RS------------------- --LPI-------------------------------------------FSS-P------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------STA----- ---------------------FTTALVMMTGELD--YESTFLT----------------------------- ----------QPSESS------------------------------VLCI----FILVVFIVLVYIILSNLL VGLAVSDMYAIQHRSEVLRLTRHVELM------------------------VQVEALF------RSRL---- -----IP------------------------------------QKMQ----------QC------------- -----LLGSISI-----------------------ISSKQKPSVSI----YPNLSLGFSD--SLFL------ --------------------------FLSRMIGTR------LLLIKLFEVYVSGFIPP-------------- ------------EHEPSLPSQL-IGEALDVARRE-HEL-------------------------DKRE-RLLH LRALQ----------------------------------------------IGATAHQRQGHSGQGTQVPVN QTSLNRVS-----------------SI----------MRPTP--IAS------------------RSSWRWT ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------IMSDID--------------------SEDDS---------- ---------------------------------------------------------------VDVLHPTVH TQNSIRASHSVAAKRTIIPDPNARLE-----------------EL--------------------------- ------------------------------------------RNMVLNLQA--------------------- ------------------------------------------------------------------------ -----------SVEALTLI----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------VKQQ DV---------------------------------------------------------------------- ----------------------------HHLP--T------------------------------------- ------------------QVPSTT------------------------------------------------ -------------NSTHEINV--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Parg1284262_TRPA5-1/1-985 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------MSG------ -----------------------------PP-S-----TVRGV----QRETPLHAAVR-------------- ---------RGDLAST--------NLLLQH-QPD-LTLKDDHNCSILHLAALARNLEIIRQLLKE------- -----------------------------------------KLCKEVLT----------------------- ----GGDCDGNSVL--------HTALL-KDCDAPEESTVQGIVE---------------------------- ------ELV---------LAGADVNSVN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---RHGESPL--------------------------FLASRQ----R------------------------L PKLVE--------------------------------FLLSK-G--ADPT-VVTR-------GGQ------- --------------------------------------SVLHAAC------------QNGSSTC-LGHLLNT NNVN---------------------------------------HLVTKSDR-D------------------- --------------------------GRD------------------------------------------- --------------------------------------------------------------------PFHY AVH------------------SGSI---------DCCELLLNNGDHLTR-LDK------------------- -DRASRCSLI-------------------------------------------------------------- -------------------------------LE--HLP-SATQLLRRLFDAHVRLSNR--------PQHDAD FRVTFDYTV--------------------------------------------------------------- LHSETEG--------------------------------------------IQSSLISELSASR------LE ALLKHPLLE-----------SFLFMK--------------------------------------WR------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------K------------------- ----------------IKAF-----------------FYCSVLIYLLFLIMHTTFI-------------I-- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----MTFGGNPRRWEDQSS----------------------------------------------------- -----------SLAIFLVLHVVMFLLILI---------PDLI-IM--FA----------------------- NFKKYL-R----------QWETLTKSIA----------------------LGSSAIVVFFFITPFKDAGKVV DAGAAATGNATNSDDILPASSAGGLGEDDD--------------DMPFVR--------SAA----AVSAFFC WVEFMMLLG----------------------------------------------RFPSLGT--YVLMFTRV AR-SIIKFIAAFFSLIIGF--AVSFLVLF----------------------RN------------------- --EGV-------------------------------------------FSN-L------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------PMS----- ---------------------LVKTLMMMIGEIE--YEDLMKM----------------------------- ---------------------------------------SKR---PVMSC----LFLVLFLFLVCVLMANLL IGLAVNDIPDLQRQGKIKRLSKQASYL------------------------VSYERLMIIARNLRCF----- ------P------------------------------------RHLRI---------LLTSR---------- --CK-----------------------------------------------------IPQ--VVSF------ --------------------------LPNKNSYS--KMRN-------------------------------- --------------HRYLPSET-LQEAIL-LGNC---------------------------EDPKEDFGNIE EDDIL----------------------------TQFKS---------------------------------- ------------------------FKMKYVRDRRAINRRLAQ--LPD------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------SSTTDK---------------------------------- ------------------------------------------------------------------LLKE-- ----------------RFDQMQQMIQN----------------QL----------------------V---- ------------------------------------------FIMQQQLPPAQ---------------QYVT PVGERSQQGGQQEQSRK------------PSLSLQQLTLHTQQQQLQ------APQQSLQQQSMLQQSVQTQ QWLQQSVQTQTVPQQFVQPQSMPQQ----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------SVETQTMLQQPVRP------------QM------------------------- -------TPQQPV-----------QTQTVSQQSIQQQSMPQQYVQPQPMPQ-----HSVQRHSISHQPVQLS SVP--------------------------------------------------------------------- ---------------------------QQFVQ--PQSMPP----PQSVQLQT----MPQPS---------VQ ---------------Q-YSTPQQ------------------------------------------------- -------------SVQGQMVPQSVETV--------------------------------------------- ----------------------------------------------------SASSTVFLTTD-GAPTTCLI TDGIS-------------------------------------TTGLTTDGASSGVHSTQD------------ ------------------------------------------------------------------------ -----------------------------------------GVARMQ------------------------- >Parg1328458_Pain2/1-961 ------------------------------------------------------------------------ --MA-------------------------------------------------------------------- ------------------------------------------------------------------------ --SKS------------------QV----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------SV-L-------- 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------HIT--------------------------------------------------------- TSLHV---------------------AAKKG-----ALKCLKVLLD--------------------AS-PP- ---------NDVLNAP-DQDG--------------------------------------------------- -----------------------------------RTPL--LVAVQETQPTVVKMLCE-------------- --------------------------------------------AGA--HVNARND-----------K-GQS ALHLLTFAVS-------------------------------------------------------KGLK--- -PENTLQ------EIAEVLLS------------------------------QQ------DI----------- -----------------------------D--L-----ESHAPL------TPLAVAASR------------L PPGDGAPRSGGLIKLC--------RDLVKA-GAS-LEEDGGDG--------------TIEEVLQQ-----KQ ALPAILMGG------------------------ERKSAPKRPAASEFLDMILLGNSVQDVQAFLKKKSAEDA HDAANCRLGKQTLL--------FHAVD---------ISNELLVK---------------------------- ------LLI---------KAGASPWTNE-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---ITNELPI--------------------------HRAASR----GHLNIFNLLIDHMKAGKKSVDLQEYS FSLIQ--------------------------------KLIES-SKKVKGA-SPDV----------------- -----------------------------------------------------------NHSGC-LHRLMEG DVI------------------------------------------MNFNQKWM------------------- --------------------------DQS------------------------------------------- --------------------------------------------------------------------TLHV AAS-----------------FNNQE----------AICELLRKGAFLGA---------------HRTVVGK- -DQANILDSV-------------------------------------------------------------- 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Parg1394090_TRPA5-2/1-784 --------------------MSCANGKV-------------------------------------------- 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------------------------------------------------------------------------ -APPAD-----------------------------------MS-----GEEADA-P---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------VTVI--NTG---------------------------- 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GAM------------------------------------------VRAKDS-N------------------- --------------------------GET------------------------------------------- --------------------------------------------------------------------PLHK AA------------------RAHSV---------PCMVALLNAGADMAS-CDD------------------- -NGESVLSYA-------------------------------------------------------------- -------------------------------LH--HLP-G---TMDAVFDHCLVTNSS--------KISTKT LEVTMNFLP--------------------------------------------------------------- LTVT--------------------------------------------YGKNQIQNLQSFVDLG-H-----A KLLSHPLCE-----------AFLLLK--------------------------------------WM------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------N------------------- 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---------------------FVKTLTMMIGELD--FGQDFVRGLSH------------------------- -----------------------------------------L---VVTGH----AIFLFFVILVSIILSNLL VALAVNDVQGLRNSAHLERLIKQTELV------------------------FHMEKNFS------------- -----------------------------------------IAAYIA----------GHVK----------- ------VPKLYD-----------------------LLMKIANVCDY----DCYNTR-------VFL------ --------------------------LPNNPKKSN------KLLMLQNKKF--------------------- -------------REITLPSHL-LANV--------SQC-------------------------LRTREAE-- -------------------------------AHDSKSS-------------TRVKRESRIRRGEYHRN--NE EDMKANLK-----------------EL---------EANVIE--VMS------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------EKVE--------------------EMADS---------- ---------------------------------------------------------------NAALNRR-- ------------------------LS-----------------AL--------------------------- ------------------------------------------EEKLERLTC--------------------- ------------------------------------------------------------------------ -----------LLTRRASDPA--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------AAP AGN--------------------------------------------------------------------- ---------------------------AGEEG--T------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Parg1450070_TRPA1-like1/1-1139 ------------------------------------------------------------------------ --MMNS------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------LI------ ----------------------------------------------RQKRVV----------YVN------- -----VNVD-----DIDGSSSRGKR-----------------------------------------PL---- CEAVMCK----------------------------------------------------------------- ----------------------------------------------DFQ-LCLKL----------------- -------------------------LNDG-ENVN-----------YTDDENGSTL----------------- --------LHILAKKY---SRQETRAQKIPKLLLQYGA---------------------------------- ----NVNAMDKD---------------------------------------------------GNTPLHI-- ------------------------------------------------------------------------ -----------------------------------A-ARE-----------------GKQ-D--------LC VILLEHQK-TN--GEN-------------------------PKVNIKNKKS--------------------- --------------------------------------------MTPMHYAAQQGQVQVVELLIRE-GANP- ---SIRDN---------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------QKY--------------------------------------------------------- FPLHH---------------------AADKG-----FHECCKVLAPF------------------------- ---------YPNDTA---QDQ--------------------------------------------------- -------------------------EL--------IPPV--MLAARKGHYLCYKEM---------------- ---T---------------------------------------DAKM--NLSYKDV-----------V-GNT ALHIVAKLGF-------------------------------------------------------------- ------E------KFVGLLLD-----------------------------MGA------PP----------- -----------------------------NT-Q-----NNFGN-------TPLMEAIM-------------- ---------KCRTNCV--------NMLMDK-GAN-LGIKNNSQSGVLHVAASKKAEDCIDSLLKN------- -----------------------------------------EYVKKQID----------------------- ----DKDKDGYTAL--------CIAVK---------KQDEKCAV---------------------------- ------LLL---------NAGASPSVVCQQKLSL-------------------------------------- ------------------------------------------------------------------------ --------------------------------LHTAAENMKSFLLEKLLTF---------PG------LDLN LQSKDGVTPL--------------------------HVAACK----G------------------------S REACQ--------------------------------MLLRK-G--ARID-VQDE-------NGR------- --------------------------------------TALHLSA------------YQGHSSV-VRLLIKS GAI------------------------------------------KHAKDD-K------------------- --------------------------KST------------------------------------------- --------------------------------------------------------------------ALHA AAA------------------KGNL---------ECCEILTDADKGLYKEQDK------------------- -KKRYALDVA---FQKGHDKVFHFLLHILPYRNINTMPQDLSEHLHSHTHNALKNRNRTIVEAIVKSHWWEA GFGA----------TKKHE--GVYCTNFRELIR--LY----PVLAMRVMDKCTTLLDT--------TSDSA- ---VYDFRI------------FEDDYY-IKGDK---------KATSPFDPK-----------TWKVLSSAEE LMSDVHV----------------------------------------WKKEHPVNI---MAHRR-C-----L GLLQHPLTE-----------AWLSYK--------------------------------------WK------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------S------------------- ---------------YSRQI-----------------FLILLFLQLFSVGVLLAFM-------------KSV Q-------------------------------------------------NWK------------------- --------------QIQDAY-------N---MT------------------QKEFCNAN------------- ---------------------------------------------------LRPFKNS-------------- FQ--SVDVNITEDATTT--------------LSIQM---AQKWNSA-------------------------- -----------VSHSCHILLLISVIVQVI---------VELN-SA--IR----------------------- MQWHYF-------------------------NSTILLVRFPC--------LILSTVLLIPSSY--------- -------------------------------------CGFRLGIKTVFIW--------QCG----IVALLIH WFHVIHTIN----------------------------------------------KVPQFSI--FTTITKDF LR-DFFKGLMFIGMVISLF--ALIFHLLL----------------------QD------------------- --QTA-------------------------------------------FKT-L------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------PQS----- ---------------------VVKTVVWLLGDLG--YDDTFLR-ET-------------------------- ---------------L------------------------AY---PVLVN----ILFLVFVCTVAIFIVTLI RAPSLDQ-----KEILLYRKAGQAELI------------------------LNFDVCY-------------- ------P--------------------------------------WC----------RRAYS---------- --VG-----------------------------------------------------------KYC------ --------------------------NKDKN----------------------------------------- ------------------P-WI-LTKIEN------FLKPKG--------------------LWVVQN----- -------------------------------LSKEFDK-----------AA-LMNIHEHKEDDKH-WIVSKL ----EKIL-----------------KI---FSYTTNENVNSE--LPH------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------PLQDQ----------------------------------- ------------------------------------------------------------------LEEQ-- ---------------------TKKLD-----------------QL--------------------LALYNQL ------------------------------------------NGNYHKQNEQ-------------------- ------------------------------------------------------------------------ ------------ILELKQH----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------LD-------------------------------------------------- ----------------------------------------------------------------------SL KQK--------------------------------------------------------------------- ---------------------------SRSS----------------------------------------- ---------------------LVI------------------------------------------------ -------------T---------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Parg1515985_NompC/1-692 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------MDK-R------------------- --------------------------GRT------------------------------------------- --------------------------------------------------------------------GLHL AAM------------------HGHY---------HLVALLMGQGAELGA-KDR------------------- -DGLTPLHYC---ARAG---------------------------------------HLDVVKLLVEAGASPE DKSTEGKTPITFAVASEHV------DVYNYLIN--KK----HDSYKLLEDK--------------------- ---KYVHDL------------TLMS----KKHGHTPLEEFILLSPAPVDLA-TKLAHSLLILSDKEKESSRD LMEASLFS-----------------EALATELVAISAATSSPGILLRAVDNRNVVLLDSLIEHE-Q-----K EVIAHPAVQ-----------RYLNDV--------------------------------------WM------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------G------------------- ---------------SLAWP-----------------AWKMVVMFFAFLFLPPVWI-------------FFS M----------------------------------------------------------------------- --------------PLGHMY-------N---EV--------------------------------------- ------------------------------------------------------------------------ ----------------------------------------------------PIVKFI-------------- -----------AYLVSHLYLLVLMILTVV---------TPPS-PI--WEN--------TS------------ -------L----------MP-NWYEWVLLLWLSGNLVMELTNPGDIAGLGWIKVFVLVFSSLGVLVHLVGFF ---------YLG-------------------------RFELILEMLYIRN--------NFL----AIALLLA SVQLLDFLS----------------------------------------------FHHLFGP--WAVIIGKL MV-DLGRFLVILAIFVFGF--SMYVAAI-------------------------------------------- --YNP------------------------------------------------------------------- ------------------------------------------------------------------------ --VRPIYAS--------------------------------------------LNATT-----------DSK YPPAEAPVQ----------------SPVQTGEML--FFSLF------------------GLVE--------- ------PDY-MPPFY-------------------------SH---PSWSQSLMKIVFGIYQMVTVVVLINLL IAMMSDTYQRIQAKS-------------------------------------DTEWKF-------------- ------GL-----------------------------------AKLI----------RNMSR---------- --TS-----------------------------------------------------------GTP------ --------------------------SPLNL----------------------------------------- -----------------LVKFI-VYIIAI------FKFKCN---------------------LCSDK----- -------------------------------AMEYMRT-----------EGRPEDPHQSDLK---------- --------------------------------TEFGGGWIKK--LRS------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------RSKAS----------------------------------- ------------------------------------------------------------------IMPQ-- -------------------------------------------ST--------------------ENLVP-- ---------------------------------------------LSNMEGP-------------QGVRRIE NVIK------------------------WSRV---------------------------------------- ---------VNRYRMMHRK----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------EVQP------------------------------------------------ --------------------------------------------------------------------GEEA GQD--------------------------------------------------------------------- ---------------------------QDLPA--DS----------------------------------VE ---------------D-LQDEALL------------------------------------------------ -------------NGGVE-NSGQASGT--------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Parg1539874_TRPgamma/1-1081 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------MGE-------------------------ED---------------------------------- RHNR------------------------PH---------------------------------------QE- ---------MGQLSTE--EK---------------------------------------------------- -------------------------------------KF--LLSVERGDVAGVRRMLV--RAKET------- ---------------------------------------------G-AMNINCVDP-----------L-GRS ALLMAI------------------------------------------------------------------ --DNENL------EMVELLI-E------------------------------------YKV----------- -----------------------------ET-K-----------------DALLHAIS-------------- ---------EEYVEAV--------EVLLDH------------------------------------------ ------------EE---------------------------------------------------------- ------------TV--------HVPGEPH---------SWEAIP---------------------------- ------P-------------ETATFTPDI------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------TPL--------------------------VLAAHR----D------------------------N YEIIK--------------------------------ILLDR-G--ATLPGPHDL----------------- ------------------------------------------RC------GCDECVTS-RLEDS-LRHSRSR ---------------------------------------------INAYRALAS------------------ ------------------------------------------------------------------------ PSLIALSSK----------------------------------------------------------DPI-- ------------------------------------------------------------------------ ---LTAFELSWELRRLSF------------------------------------------------------ -----------------------MEHEFRSEYQ--ELRKQCQDFATALLDHTRSSYE--------------- LEVLLNH-----------------------------------------D----------------------- --PTG-PP-------------------------------HEHG------ERMHLSRLKLAIKLK-Q-----K KFVAHPNVQ-----------QLLASI--------------------------------------WY------ ----------------EGLPGFRRKNMALQALEIVK--IGLLFPIFSI--VYTLAP---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------HTSFG--------QTMRKPFIKFICHSASYLTFLCLLILAS--------------QR IETVIV--------------------------------------------DW--F----------------- ---------------------------G-------------------------------------------- ------------------------------------------------------------------------ ----ATPT-LKKWVATDVT----------------------------------------------------- ------TRRGAPPSLVEWLILAWVFGLIW---------SEIK-QL--WDV---------------------- GLREYV-A----------DMWNVIDFIT-------------------NALYVATIALRIVAYYQVQREIREN LETD-------KLP-----------------RQ-------------NWDTWDPMLIAEGLF----AAANIFS SLKLVYIFS----------------------------------------------VNPYLGP--LQVSLSRM VV-DILKFIFLYLLTLFAF--SCGMNQLLWFYADLEKQTCIEEG-SKGDENDKNTTDMPGTEDIR------- PNVDS------------------------------------C-IVWRRFSN-L------------------- --------------------------------------------FE-------------------------- ------------------------------------------------------------------T----- ---------------------TQTLFWAAFGLID--LTNFE------------------------------- ---------------LTGI--------------------KPFT--RFWGM----LMFGTYSVINVIVLLNLL IAMMNHSYQLVSERADTEWKFARSKLW------------------------ISFFEE--------------- --GGTCP-------PP--------------------FNIIPTPKSLYY-------LLHWFYK-------KFC GQTK----------------AAKK----------EHMRTIR----------------------SIMRNLVR- --------------------------RYVTVEQRK------------------------------------- ------------AENQGVTEDD-VNEIKQDISAFRCELVEIL------------------------KNSGMN TSTAAA-----------------------------TGQGILP------RGSSGGKKNRQKER---------- -------------------------RL------------MKG--FN-----------------LG------- ----VNSLS---------------------------------SQLN--------------RGTSTIL----- ----------------------------------------PAATEV------------VEVAVKRSPQ---- ---------------------------------------NKLA--------------RLAR----------- ---------------------------------------------------------------LAEARLGRP --------------------TNKK----------------RWGTL-----------------------VEAA K-NAKVKKLL--SR---------------------------SRSDESL------------------------ ------------------------------------------------------------------------ --------------SSDPGNEITGD--SEDARG--------------------------------------- ---------GNETP---------------------------------------------------------- ------------------------------------------------------------------------ ------------------------T-----------PLQ---------------------------SLP--- ---PGILR----GGDGISETIRRER---AESG--------------------------------------VS GT---------------------------------MHLDAAALVCQQEQ---------V-KRQP-KNSVSFD QSA--------------------------------------------------------------------- --------------------------LGGASS--S------------------------------SP----- ------------------SHSS-TETEPPP-----------------------------------------P Y----------PQWLR----------PVSST-------STV------------------------------- --------------------------------------------------TEP------------------- -----------------------------------------------NPTTTSPSS-GSGSLPPLAVSESSE PLVG--------SGPP-------ANGSV-QPPRL----------------------PG-------------- ----------IQPVNRH--------------------------------------------MAAGWL----- >Parg1578842_Pkd2/1-789 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------M-------------------- -------------------------------------------------SN--------------------- ----------PASELER------------------------------------------------------- ------------------------------------------------------------------P----- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------DTNGSNRQAWGQGC----------PGSPGG G---------------------------------------------------------------TAVDTY-- ---EYENNETI------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------RKK---------------- ------------------------------------------------------------------------ ---------------------GCWYSFST------------------------------------------- -----------------------------------------CVS---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------RM--WATRQMTKKEDREIYVR--TT-------LRE LV-----------------------------------------VYIIFLIILCILT-----------F-GMT SPTMYY------------------------------------------------------------------ --YTKVL------S--DLFL---------------------------------------------------- --------------------------------------------------DAPYPDTK-------------- ---------NTFRGST--------QV---------------------------------------------- ------------------------------------------------------------------------ ------------------------------------MDFWRFTE---------------------------- ------NVML------DGLYWEYWY----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------DV---------------------------AITSTE----E------------------------D DRNI---------------------------------LYENR-M--LGVPRMRQV----------------- ------------------------------------------RV------RNDSCTVP---DDF-QRAIRQC ---------------------------------------------YDVYSP--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------AAEDKRNFG---E-QNTSAWRYHSEQEMKGSSH--------------- WGKIATY----------------------------------------------------------------- ---------------------------------------SGAG---------SYQDLGL-NRSV-S-----K DILA----------------DLRQNL--------------------------------------WI------ ----------------Q-----RGTRAVFIDFTVYNA-NINLFCVIKL--LFEFPA---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------TGGVI--------PSWSFRTVKLLRYVTPMDY--FVLACEF---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------IFVFFII-YY-------IIEEAL-EI--KTL---------------------- KCA-YF-K----------SIWNILDLLV-------------------IGISLMCIGFSIFCTFSISSKLEEL LADP----------------------------N-------------TFADFDFLGYWQTQFNSAVAVCVFFA WFKLFKYIS----------------------------------------------FNKTMTQ--LSSTLSRC AK-DVAGFAIMFFIVFFAF--AQ-LGYLLF--------------------------G--------------- -------------------------------------------TQVRDFSS-F------------------- --------------------------------------------IN-------------------------- ------------------------------------------------------------------A----- ---------------------VFTLLRTILG-------DFN------------------------------- ---------------FHEI--------------------EDAN--RILGP----IFFLSYVFFVFFVLLNMF LAIINDTYSEVK----AEIANQRNEFE------------------------IADYFK--------------- -------------------------------------------RGYNN---------------------MMG KLGK----------------RDKV---------VDIQNALKLS---------DTNGDGLLTFDEIRVNLKKC NFS----------------------DMEIEMFFAK------------------------------------- ------------YDTDGSRLLE-ADEVKRMLADLEGQRMELDT----------------S-KTQGEKQIKRE EQPGSGKASTEVETRPASAS---------------SGHGSFA------SV-SFEEFSVLQRRVD-------- -------------------------RL------------EHS--IG---------------SIVSKIDA--- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------VLVK----------- ---------------------------------------------------------------LDTMEKTKH --------------------KRRE----------------TMGKILD-------------------TITENE GLDETAKRNYMEKL---------------------------VRDELERWDGEG------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------SPPM--------------------------------- ------------------------------------------------------------------------ ----------------------------------------------------------GRK----------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Parg165214_TRPMc/1-1508 -----------------------MV----------------------------------------------- VIMSQQERQR-------------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------------------AAS------------------------ ------------------------------------------------------------------------ ---------------------------------PDPFT--------IF----------HESNPTEFE----- -------------------------------------------GWMTPSTPN-------SGRWAQSARA--- -----------------------------------------------------------------------R RRQISAHSRAS------------------------------------------------------------- -------------------------------------------------TMSVSTN-LDPG----------- ------------------------RSSGNDENTSYG---------LNN-QRW-TLQRK-------------- -----KIGLQRPPLTA-------------------------------------------------------- ---SERSV-SRQ---------------------------------------TV-INLAF------------- ------------------------------------------IRTHFQRK------------------ECVR Y-------------------------------VRNPKAFKEGSCYC-----------GLMEKEH----IPPS LLLAHPQPSSSPEGG-----------------------EILARVLEDLQEEKPGFG-------T-------- ------------------------------------------MILNALNFNFVKSQVFAPIRLPSVSPHSP- ---TPLDPT--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------QD------------------------- ------------------------VEVGYGQ-DDGPL-------------------------R--------- ------------------------------------------------------------------------ -------TILQANGVTP-------------------R-YSNSLTSRHFPTSLPHPASVEDRLVLPPVRSRWT RSTHL---------------------REFPTN----AYGVITIANET-------------------AG-SN- ------------------------------------------------------------------------ ----------------------------K------PSKYV-RLSCDTPMKSVLTLLSDYWRLLDPHRPQL-- ---VISVTGGAKNFQLDGTKKQTFS-------------------SGLIKAVKSTRAWL-----------LTG GMNVGIMRSVGEAV-------------NKGQYIVKVKQRTLFEEEHEHMMRGIRCLGVVPWGYISNRDQ--- -LVNTDP---TQFASVRYKVEDEVNRFAPVPLNGDHTHFLLVDDGTRNSFSGV-----DSFRTRLEEA---- ------------IQD-----------------A-----EPQGL------GVPVVLLLLEGGLNSIIKCSMAL KSNIPILVVAGTGRAA--------DLLAYA-----ASMTIHT------------------------------ ------------PS----------GQY----------TMRKGHRAQLLSRISV------------------- -----------TMQ--------EFQPY--------PDKQKKCAD---------------------------- ------LLI---------ECCTKVNMIT-------------------------------------------- ------------------------------------------------------------------------ -------------------------------IFDINSDEGMDKYILYALLTGE------------------T QTTRLGLDQL--------------------------GLALLW----D------------------------R PDIAE--------------------------------THIFP----AQKS---------------------- ---WPSGAL----------------------------EDLMTTAL------------LEEKVDF-IKLF--- -----------------------------------------------VVNGLVM------------------ ------------------------ADYLT------------------------------------------V AKLR----------------------------------------------------------------HLYN KACEGNKHLSQMLKRRSQLHLH------HLIHVHHLLVAMMRQHHHAAYQADTPEAFIDNPSVNYLT----- -FEDPYLELLVWSIFSGR------------------------------------------------------ ------------------------GQLARHAWQ--RCN---SPLCATLVASCLCRSLW-------RSLGATI TDLRDQYQRHKDDFEHLAVDLLAVCYE-------------------------------------EDIVNAMS LLEQRNVRWG-------------------------------------EVDCLELAFMA-------ND----M NFISTPAAQ-----------ACIVLN--------------------------------------WQ------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------R------------------- ---------------GMSRA-----------------PFYAVIVANICPLLIFWTR-------------PFC FQ---------------------------------------------------------------------- -KLGD----------------------NGGELT-----------------ALQKLS---------------- ---------------------------------------------------------------------V-- ----FYKSPISKFYAHSTA--------FVVFLALYA--------------YVVLFDLRY------------- -----------EMSVTEMVLILWIMVFIM---------EEIW-EI--ASK--------RSL-------TLRG KIVEWF-G----------SVWNRFDVVS----------------------LLLAFVALGLRLPRSTF----- ----------------------------------------------KWGR--------ITY----AVNTTVF YCRLLRIYH----------------------------------------------VNYHLGP--KLVIFYRM IS-EVLVFMALLVIFILGY--GIASQSLL-----------------------------------H------- LTRDA---------------------LS--------------------LNT-T------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------AVS----- -----MIMKDI----------FLTPYWQMYGELQ--LEEIKGEDVEMCH----------------------- ----------PQSCLERQTCDVSGTDSCLLVQECLCENPRDY---SWVVY----LMLFFYLIIGNIMLLNLL IAIFTYVFDEVQENSMEIWKFEMYSLL------------------------HEYDS---------------- -KPALMP------------------------------------PLVIF---------QYIWM---------- ISDK-LWSLL----------RQKHHKH------------------------------LDSFMKDTL------ --------------------------EPLKIFEKEATNTYLARITMAEE----------------------- ------------SSIDRRVQKM-SDKIDK------------------------------IAKYIEQKEELEE MEVDLE-----WI----------------MHEREELQQNKE-------QKL---NQRSKTLEVSED-----N HQPQPS---------------------MADLRDGPAEPDSEE--QTDTIA----------EDL--------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------SDGDIERELSHLQGKQVAEGQPYSAKSQTSA---------- ---------------------------------------------------------------TYLAQRQQV ---------------GQMASLSRRFD-----------------YLQ-------------------HQF---- ---------------------------------------HHTHTNLHASLTNL------------------- ------------------------------------------------------------------------ ---------HSTLTTILSR----------------------------------------------------- ------------------------------------------------------------------------ ------------L----------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------DNLEKN KNN--------------------------------------------------------------------- --------------------------RSENN----------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Parg167221_TRPA1/1-1222 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------------MY RKTDR------------------------------------------------------------------- ------------------------------------VRIVEPEMVRLMPYSNS------------------- ------------------------------------------------------VQNTGMSSP--------- ----------------------------------------------------------------GSRKGSVS GDSLYQEVT-----DIITMNQ-------------------------ENGRG--------------------- ------------------------------------------------------------------------ ------LTSYDLI-------------------SRTLHQLARDGNSEVLSSALARL----------------- -------------------------GEHGRRRIN-----------NL-DGDRLAP----------------- --------LHYAAR---------YAHADTIKTLIHAGA---------------------------------- ----LVNIRGQD---------------------------------------------------KLTPLHYAA RYRRQIKPNRKHSPLPAPPKDEEEEIEPE----DENEENAKEEHEKYNLTITSAQSV------AGIGVESIS ES--SVIRILVECG----AEVNARDIYDQTP-LHYAAMRG-----------------NDP-A--------AR DLLKCPQ--V--------------------------------FYEARDKQL--------------------- --------------------------------------------MTPLFVAATFGYVDICRRLILA-GASL- ---FSKDE---------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------SE----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------Q----------------------------------------------------------- TPLHR---------------------ASMEG-----HLEIVELLLS--------------------SG-SVE GGDKTVHRLVSERDS---EGQTPL---------HHAVNNGHIQVAR-------------------------- -----------CLLDAGADVDAVRDTL--------ATPL--HAAASVGDKDLILLLLE-------------- ------NHAR-----LGSVDCNQ-----------------------------------------------QT PLHRAAAHNQ-------------------------------------------------------------- ------S------EAIETLLE-----------------------------AGA------KI----------- -----------------------------ER-R-----DKDSF-------TPLLVAAS-------------- ---------GGHESAV--------QTLLDH-GAA-VDAVDKDDKTAVYWCAEQGNDRALEVLLK-------- ----------------------------------------DTRCQELVD----------------------- ----VSDRFDNSPL--------HEAAR---------NGYINVIN---------------------------- ------KLL---------ETGSLIDNKNEDEETA-------------------------------------- ------------------------------------------------------------------------ --------------------------------LHLAAEAGQVRVVRELVQR-------------YK--FLIS DENEESNTPL--------------------------HLACLQ----G------------------------H AEIVQ--------------------------------VLLEA-G--ADVE-ARNS-------SLW------- --------------------------------------TPLDCAS------------AKGHVQC-VHHLLDY DSP------------------------------------------LDPLDK-T------------------- --------------------------KTT------------------------------------------- --------------------------------------------------------------------PLQL AAT------------------EGHV---------AVTQLLLKRGASLAA-CDT------------------- -SGRNALELA---IAAS---------------------------------------KRDVCLAIIKSPEWKT GL-----KNVRLDYRGRRV------TPFRMLIK--KF----PDVAEAVLDRCTSTNGM--------DSDDRR FAVLFNFEL------------VDDTYT-ILEYGSDI-DSVASVSTLESA----------FDEDGQLLEHAEP YTNDARE----------------------------------------LKGNHPLML---MVKYK-R-----L NLLAHPVSI-----------SLVKHK--------------------------------------WM------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------N------------------- ---------------YGRFV-----------------YYSTLAFYAVFLVFLTGYV-------------LSA R-------------------------------------------------NWIS------------------ ------------I--KGEMN-------N---TE--------------------------------------- -----------------------------------------------------GNAIM-------------- VQA-AKEQSSCEDIEDK-LNLTNNL----------------------------------------------- -----------FVIAGKWVIIVMAVINIM---------REMF-QF--YQG--------CCN-------SL-L ARLNYIGL----------E--NLMEWCC----------------------YITAVLLVWDFNN--------- -----------------------------------------CPIRQDWQW--------QVG----AASIFLA WMNLLLFIR----------------------------------------------KLPFLGI--YVVMFTDI FA-TFIKFFTVFLLFIVAF--ALSFYMVL----------------------KS------------------- --KIP-------------------------------------------FGT-P------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------AKS----- ---------------------LLKTTVMMIGEME--FDSIF------------------------------- -------NE-EE---L------------------------DY---PQITY----VVFVAFLILMSILIMNLL VGLAVDDIKAVQDQAILKRLAMQTQMV------------------------LDVEVLI-------------- ------P------------------------------------ETLR----------RMYVV---------- --SK-----------------------------------------------------------KEV------ --------------------------HPNAR----------------------------------------- ------------------HGLF-SRLFGD------F------------------------------------ ------------------------------------------------------------------------ -------------------------------------QLIKG--FDF------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------VEDAE----------------------------------- -----------------------------------------------------------------QMSEQ-- ---------------------EVMRH-----------------DL--------------------TKLIAQV ------------------------------------------E-DLRSQNQR-------------------- ------------------------------------------------------------------------ ------------LHSLLFA----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------LTSF------------------------------------------------ --------------------------------------------------------------------RQRE DK---------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Parg173062_TRPA1-like2/1-1172 -----------------------------------------------------------------------M SGQNKTH----------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------IPLLQ------ ----------------------------------------------RFSRGA----------HRNKKKPAKV GAHV-VTIE-----DNSSRPWRQNR-----------------------------------------NY---- ERAVSVRERYDRVG-DTNNA---------------------------------------------------- --------------------------------RKYTEELLQKVEDNDYD-ACQIL----------------- -------------------------LEKH-ANVN-----------VKDEETHSTA----------------- --------LHIAAK---------NDFHDILVLLLDKGA---------------------------------- ----DCNAQDRT---------------------------------------------------EQSPLHLAA ------------------------------------------SKGHFFI----------------------- -----CEKLLECNS----LKINISNKIHDTP-LHHA-AKE-----------------GRL-D--------IC IMILKHPD-I--------------------------------NVNAKNKRG--------------------- --------------------------------------------MSPLHLAAQENHHKVVQHLMDN-GADW- ---KLQDK---------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------NFH--------------------------------------------------------- LPLHY---------------------AAQKG-----FPETCEVLMSN------------------------- ---------CIDADK---EKQLKV---------AL------------------------------------- ------------------------KDG--------KTPL--MLAAKGGHHYCCEKL---------------- --------------------------------------------TNT--NINAKDK-----------E-GNT ALHYAAIGGY-------------------------------------------------------------- ------E------NTVAELLD-----------------------------MGA------QP----------- -----------------------------NA-Q-----NKRGN-------APILEVSG-------------- ---------KKRVGCL--------RILVEK-GAK-LSVTDKQNKTVLHYAADKNAEECLKYLLSF------- -----------------------------------------PTIKALLN----------------------- ----RKDDNDCAPL--------HAAIK---------REAVECAH---------------------------- ------ILL---------ESGASPVDSCIGGMTP-------------------------------------- ------------------------------------------------------------------------ --------------------------------LHLAADKGYTGICEILLSR---------SE------VQVS QENETKATPL--------------------------HLAALR----G------------------------S TDVCQ--------------------------------MLLRK-G--ARLT-AVDK-------NGR------- --------------------------------------TALHIAS------------AKGHYGV-VRFLCKK GVP------------------------------------------QRARDD-T------------------- --------------------------GSI------------------------------------------- --------------------------------------------------------------------ALHH AAY------------------AGSL---------ECCKVLVVNAKATCCELDQ------------------- -NGHLPLDRA---FENKHDGVFKFLLTHLPYKE---TQEDRMLCLHRYMHTALCENRVTAAEAIIDSPWWQA GFIG----------ENGHH-----CQNFRWLIK--HQ----PSLAMKVQDKCISCSDS--------DLVVT- ----YDFRF------------FEDNYY-IPTAI-------GKIAKSPFEEK-----------DGKLSQNAHQ FIEDGLE----------------------------------------WKNNHPLSL---MVSHN-R-----H QLIHHCLTN-----------AWLLHK--------------------------------------WN------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------S------------------- ---------------YIYLT-----------------FLILLMLEVLFVTCLIIFM-------------GNV D-------------------------------------------------NWS------------------- --------------HIQARC-------N---FT------------------REQFCSVSEV----------- ------------------------------------------------YPKMQVPSLK-------------- HN--VSGNEVAEKDTEG--------------LGIFHD------NAT-------IIRFGEC------------ ------DEGVPVKQGVWLALLITTFIELL---------LECN-FI--YT----------------------- LRREYL-------------------------SLDSV-IRLLR--------AIFTIFILVPGGS--------- -------------------------------------CEFHHHIMKVWQW--------QFG----IIAMLVG WMHLINMLN----------------------------------------------QLPMLSV--FMPITDSF LK-SFFKVLFYIIMLVFVF--AFIFHLLL----------------------RD------------------- --QAA-------------------------------------------FLT-V------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------PQA----- ---------------------MVKTIVWMLGDLA--YDDTFLNEEYS------------------------- ---------------L------------------------LY---PVMVN----CLFVVFVTTIGGFIVNLV IAQPSEKLDDFREKAAIYRAVSRCKLF------------------------LRLDICF-------------- ------P--------------------------------------FF----------WKYKT---------- --KG-----------------------------------------------------------TS------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------VDEVTKGNGY-SILPR- -----KLL-----------------ML---DNKLE----EVE--PLN------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------PFQAQ----------------------------------- ------------------------------------------------------------------LEEQ-- ---------------------NMQIA-----------------TL--------------------LTL---- ---------------------------------------------HMEQREE-------------------- ------------------------------------------------------------------------ ------------LRDLKHL----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------LNVI------------------------------------------------ --------------------------------------------------------------------TKTL QKD--------------------------------------------------------------------- ---------------------------EDS------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Parg1731761_TRPC/1-1319 ------------------------------------------------------------------------ --MPA------------------------------------------------------------------- ------------------------------------------------------------------------ --------IRGVE---------------------------------ADVEEIKL----------KDS----- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------F SSNNSRAN---------------------------------------------------------------- ----------------------------------------------SIARALKKKI----------S----- ------------------------------------------------LTR--------------------- ----------LTSRTSL-VAD--------------------------------------------------- ---------------------------------------------------------------KDKEE---- ------------------------------------------------------------------------ ------------------RERERRPSKE------------------------------RY-P-----TFTIE DWEEGEH------NGAFREDSVFKDDS--------------RADDKSDYDG---------------DTDLGE DGDGE---------------------------------------------------------GVSLV----- ---DNEDIRSV------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------TSS---------------- ------------------------------------------------------------------------ ---------------------KRTSQLSV------------------------------------------- -----------------------------------------DRS---------------------------- --------MVKCGR----AKFFKRLSVCDLK---STSD---------------------------------- DEISW----QELREEECDHHECGPDGLSPKPLTRHLSVLS-----------------------------QD- ---------GHMMDPK--ER---------------------------------------------------- -------------------------------------VF--LEAAERGDKHTMMRCL----SPPS------- -----------------------------------------------AVNVNCTDI-----------L-GRS AIQIAV------------------------------------------------------------------ --DNENV------EIVELLLLQ------------------------------------ENV----------- -----------------------------KI-G-----------------DALLYAIT-------------- ---------EGVYKIV--------EMLINH------------------------------------------ ------------PS---------------------------------------------------------- -----------ITP--EMLAN-----------------DWVKVR---------------------------- ------AG---------GE-ESSDFDPNI------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------SPI--------------------------ILAAHC----N------------------------Q FEILQ--------------------------------LFLSR-G--AYIDKPHPL----------------- ------------------------------------------SC------SCRQCTED-FHLDS-LRYSLRR ---------------------------------------------IHTYRALAS------------------ ------------------------------------------------------------------------ PAWISLTSE----------------------------------------------------------DPI-- ------------------------------------------------------------------------ ---LAAFRLSWELERLAR------------------------------------------------------ -----------------------VENEFKDTYL--ELSDQCKKYTCELLHQCRSTRE--------------- VIAVLNRRSE-------------------------------------EDSD--------------------- DDDDEDDP-----------------------------------------QQLKLSRLKLALKYD-Q-----K QFVAHPNCQ-----------QLLTSV--------------------------------------WH------ ----------------EGLPIWRRRNALVKILLCLS--IIICMPIIAI--IYLIFP---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------RTRLG--------RVIRSPFMKFIYHSASFGLFLVLLVLAS--------------TR TEGSER------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------HRR----------------------------------------------------- ------NLRGPAPTFVEWLIFFWVTGMVW---------AECK-QL--WEE---------------------- GLTAYI-R----------QWWNWLDFIM-------------------LSLYLCTFSLRAVAFVQITTNKYG- ---------PREVP-----------------RA-------------QWPPNDPTLIAEGVF----AVANVFS FARIIYLFQ----------------------------------------------TNPHLGP--LQISLGCM II-DIAKFLFIFFLVLTSF--ACGLNQLYWYY-DSPTASCDTSA---------------------------- -GDIA------------------------------------C----NSGSD-A------------------- --------------------------------------------FNT-------------------DGGEY- -------------------------------------------------RGGFKTLDV--------T----- ---------------------FATLFWSLFGISS--PKSTD------------------------------- ---------------LEEE--------------------HGFI--ETVGQ----GLFMAYHVMSIIVLINML IAMMSNSFQQIEDHADQEWKFARSKLW------------------------MSYFDP--------------- --GSTLP-------AP--------------------FNLIISPKAIFYFMRNFKNCMQYI-----------C FRRG----------------HRHSDKR--R-SFTMEKGALQ-GGAP------CGRMGQNNKYAEVMRRLVS- --------------------------RYIHQTKKQ------------------------------------- ------------HRQDGVNEDD-LLEIKQDISSLRYELREDR------------------------KRETAR AYGQMDS----------------------------IKKDILR---------LLKQSGRMSSRTGS------- ------------------------GRE------------SE----G----------------AVGGASV--- --NPV-------------------------------------------------------VITTTTASCTAC GNTAA--------------------------ALGFNSPSHPSLGTP---------------GIIQQHSVDL- -------------------------------GMLGREPSS-----------------GAVD----------- ---------------------------------------------------------------ITVTPASSL -------PCNL---------TYSQASMGLPSPQ----SLLPSGNLTG--------------------CLLAP QEMDYLRKEIV-SS---------------------------LRCELRDMLRDA------------------- ------------------------------------------------------------------------ -----------LSRALTPTTTMAPQ---YYSPT--------------------------------------- ---------PTPNP--------TPQ-YVTT---P-TAQTTQMPAPQ------FPPPP--------------- ------------------------------------------------------------------------ -----------------------------------PPPS--------------------------------- -------------------------------------------------------------------SQQQQ GGQC----PPSLGP--------HHSLPSP-----TSQMPHHPHIRVSGSLS--------DPVAPRSSAGQQS SPRSSP------------------------------------------------------------------ --------------------------VPQPSP--RSSP--------------------------TPQ----- ---------------PCQRSNS-S----------------------------------------------YV L----------SQRSQGGSQSSSSSKTTTNQ----------------------------------------- --------------------------------------------------------VL-------------- ----------------------------------------------LRPPNES------------------- ----------------------------------------------------DRV----------------- --------------------------------------------------HTHM----YTQL---------- >Parg175616_TRPM/1-1771 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------MAGPR-------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------WVESVFNKRE----------CIK--- ---------------------------------------------FIPSSK-DNA----------------- --RCCCGQLWQYHRDGS-PATLRHGE---------------------------------------------- --DLHWSPSRHT---------------------------------------------------QLLPTDAYG TLEFQGGAHP--------------------------------TKAQYMR----------------------- ------------------LAHDTRPEHILQL-LTGE--------WGLDLPKLLITVQGGK-T-----NFDLQ PKLKK---------------------------------VIRKGLLKAAKTT--------------------- -----------------------------------GAWVFTAGTNTGV---------------TRHVGEAL- ---VSESSPRV------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------RSG---------------- ------------------------------------------------------------------------ ----------------------RVVSVGI------------------------------------------- ----------------------------------------APWG---------------------------- --------VIERRQDL-------------IG-----RN---------------------------------- KDVPY----HPIN--------------SPKSKFVALNSHHTFFLLVDNG-------------TVGKYG-PE- ---------LILRRKL--EN-------------YISQQRIEARGGL-------------------------- -----------------------------------ATPV--VCVVIEGGPQTIRQVLE--YVTDSP------ -----------------------------------------------PVPVIVCDG-----------T-GRA ADILAFVHKCACTG-------LNITEANRDTIILTLERVFELRPMQAEK-------------LFAEVLQ--- --CVRKR------DLITVFRLK----------------------------------EGSEL----------- -----------------------------DQ-S-I--------------LSALLHAQR-------------- ---------LNPPE----------QLSL-------------------------------------------- ------------------------------------------------------------------------ ------------AL------------------------TWNRVD---------------------------- ------IA------------RSHVFNEDVEWS---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------QGSL----------------------EQAMMDALVN----D------------------------R IEFVK--------------------------------LLLEQ-G--VTMNKFLSI--------QRL------ --------------------------------------EELYNS-------------KSGPSNT-LRYIIRD --------------------VKK-NVPRDYRYTLIDIGLVINKLMGGAYRAFYT-----------RKKFRTV YENTMMRSP------------RLQRNNSSI-----------------------------------------F QASKSLL-----------------------------------QKSSNSSPKSCISQGDVHSKFEFD-YPFSE LLVWAV--------------LTKRQ---------GLAMLMWQHGEEAIA----------------------- -KALVAAKLYKALAHEAADD---------------------------------------------------- ----------------------DLETEVYEELK--GYAKEFEILALEVLDYCYQQDDD-------------R AHQLLTYELK-------------------------------------------------------------- -------------------------------------------------NWSKQTCLSLAVAVN-H-----R ALLSHTCCQ-----------ILLADL--------------------------------------WL------ ----------------GGLR--TRKNTNIKVM------LSLLFPPLIL--VLGFR----------------- -SREELKTMPQTREEHQDD-------------DPERSD-SESDTESDEDNLD-------------------- --MR-NEHDPEAQLVNSVSLPSHPVTPTLQSEAPLCNSNNAASLSSTLLAPPSQPE-VTNTVDGH------I PPVRQNGVST---------------------CHLSVLDSTIFNDI------------------------NSK QLPAR-----------IKLY--------EFYNAPITKFWAHSIAYVFFLCLYTYVV-------------LVR LPK--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------QPEWMEWYVVAYISTLIL---------EKIR-EI--LST----EPV-----------ELKQ KIAVWS-D----------KLWNVCDMVF-------------------AVLFMSALPLRFQ------------ -------------------------------------------------EQT-MQTGRVIY----CVDIIYW YLRVLEILS----------------------------------------------ANKYLGP--LVMMMGKM IK-NMAYFVVLLLVVLMAF--GVCRQSILFPN-------------------ED------------------- -------------------------------------------PHWRLARH--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------I----- ---------------------FYQPYFMLYGEVF--AGDID---------------PHCGD----------- -------E-GEIP-CHPGR---------------------------WITP----TVMSMYLLVANILLINLL IAVFNNIFTSVNSISHQVWMFQRFQVV------------------------MEFEGK--------------- ---PVFP-------PP--------------------LIILSHIHRIIK----------YCFR---------- --RW----------------KGKP---------FLYDNGLKLFLDG------ESLERLHDFEEECMDGYNR- -------------------------EKEQREQMST------------------------------------- ------------EERVRVMAER-TEGLMQRIEDMHGKFIAAMT----------------SVNNLDFHVKRLE ETVDQIKCSYAVVHRFMLSHVG----------QRRSSSPCSG------SGTPRSDGG--TSRSVSQTSL--- ------------------------HRL------------LEE--TEQR--------------MHRRHA---- -------------------------------------------------HEAD-------ASDKEM------ ---------------------------------------SD------------------------------- ----------------------------------TTDAEHEVG-------------HKHRK-------SA-- ----HNVISFEEHVKSSNPTGT------------VEGFKL---------DCMNT----------VNARKPKA ---------------HNH-RSKPRLD-----------SESGSSLGR------------------------AS RERKLS------------------------GG---------RKSSIRKSTKKNDDVGK-------------- ---------------------------------------------------ALSPSR--------------- ------VCF----RDLDNGDDSDSG--DGDTGVNK--------------------------------LSAE- EEMHIRYVRSLSAP-DETAALCSPP-KYERSL-S-TSS---------------SRPRIQ------------- ------------------------------------------------------------------------ ----------------------------------VIPPSS-------------------PPPIFT------- -------------FTSEYTSLADE---------------------------------------------LET VCMSRLSPPSSP------------HLHYPSG---VVPKLQRHNCPESA--------GISITISS----NPLR DAEEADYQLMEGLIQRRMHRDSENLAVSLEDLCSVKTDLSDTEDGAT----------------------PLS AR---------RDSVSTRRDSKVVALLRKRHS--TTSID--------------------------------- -----NNPSELLSV-P-GSIQL-PSSQTTSP-------TLHHSS---------------------PLCG-KG -----------IRLTSSQPGSPNTRRSSLRGD--------------------VHIHWASSGAIPPFGGWLTP RSSP----------RPQSPLFV----------------------------QPQISATL-------------- ----------------------------------------------ETS-SEYASHSRDPQPSM-------- ------------------------------------------------------------------------ -------ATLQVPV----------------------------ISETEAR-PKDTV---TETEC--------- >Pcla11004962_Pain1/1-924 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------MA---------------- ---------------------------------------------GY--LALRSME---------------- ------------------------------------------------------------------------ ---------------------------------------------------------------GNGVAAQGS -------------------------------VPPGGE-----DEDHNKQE---------------------- --------------------------------MLVA-VQT-----------------GDK-E-------KLQ YALKQL----------------------------------SPKC-IN------------------------- ------------------------------------------------H-------------VFPH------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------PVYA--------------------------------------------------------- TALHI---------------------AAQNNS-----TELVDCLLK--------------------EA-AD- ---------PNVRDLR--GKK--------------------------------------------------- -----------------------------------YCPI--HYAAHNGNLEIIQALLR-------------- --------------------------------------------ADA--DPDAKEG-----------EFGRT ALHILAT----------------------------------------------------------RW-K--- -TNEDN----FK-ACLDALLS-----------------------------C-K-----IKV----------- -----------------------------DT-V-----DSSQS-------SPLFMAAT-------------- ---------KSWEYMT--------RQLILK-GAS-IDLAVGN--------------KTVADVIRKKLPGLL- -------------ETIDFSLIEKPQRYFGDELYKALKDGDLEVFREILYEIKNS-GKSST------------ -DILEEDHGDYTLL--------QRACD---------DGLSDFVE---------------------------- ------ELL---------KNGADPTKKD-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --NTSKMSPI--------------------------LYATRN----G------------------------F HKIVE--------------------------------MLIKT----------MKE-------RGY------- ---LQKGA---------------------LKETDLRKETPLHKVVKREY-PSKN--EGVNYYRC-LQILLDK KHY----------------------------------------LDIDYQDE-F------------------- --------------------------DNT------------------------------------------- --------------------------------------------------------------------PLHY AVL------------------CDDQ---------SFVRTLLLNGAHLGI-RNK------------------- -FGTLAITRIQ------------------------------------------------------------- -----------------------------------------ASVLEEVLNDCIKHK---------NNVADRD FEIIVHYSM--------------------------------------------------------------- LAP----------------------------------AQASQQ--------PETECLRFLSGSR-N----HR RLLRHPVID-----------TFLFLK--------------------------------------WQ------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------R------------------- ----------------IRQY-----------------YFFNIAAYTAFLILLTAYV-------------LIY HG------------------------------------------------TFIPL----------------- -S-ED------------VSQ-------N---NT-------------EVP----------------------- ------------------------------------------------------------------------ -DL-NDTTSNVETVSEMIM----------------------------------------------------- -------ENLVIKFIFKGIISLFALYIAV---------REGI-QF--FV----------------------- SWKLYV-S----------RLENWLEISI----------------------VLLTAALLFIPLG--------- -------------------------------EK-------------SLQ---------SLS----AWLVLFS WIEFILLLG----------------------------------------------RHPYFAV--YITMFTTV TY-NFLKFIMMFSFMVIAF--SISFYLVF------------------------------------------- QVDDN-------------------------------------------FMT-Y------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------HQS----- ---------------------LLKTIAMTTGEIE--YTELPLS----------------------------- ----------------------------------------SF---PVSSH----LLFVLFVFLIVLVLMNLL NGLAVSDIQQIQQEAEIVSYSSRVELI------------------------SYIESVFLASPF--------- --RRIVPGP--------ITCCETG--TDDCYLTSCLNSPNPVMKLL-----------NWMGR---------- --RTLMFHSC-----------------------------------------------LRD-PYIIV------ --------------------------YPNRG-------------VDRWH----------------------- -------VC--DCHSFHLKETQ-IEAAKD---------------------------------VVLEKEHAVS D----------------------------------------------------------------------- -------------------------------------HR--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------LSGLENRLD-----------------EV--------------------------- ------------------------------------------MAAISSLTEK-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------VNKHVL---------------------------------------------- --------------------------------------------------------------------CPSP Q----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------K------------------- ----------------VRKY-----------------FLANVIFYFLFVLSLTAFL-------------LSS S-------------------------------------------------NCPES----------------- -INKDNN----ETFTGRLKV-------R---HT---AG---------------------------------- ------------------------------------------------------------------------ ------SNGTTV-VCRWAG--------------------------EEA----GVVG---------------- --------------LTWWCLVIFSALLDF---------REVI-QL--MQ----------------------- NPLIYI-Y----------NLGNLLDA-A----------------------LVFCVPQLLVGGS--------- -------ADETATN-----------------G-----ELAMCCLA-IWQQ--------RVA----AIAIILA WVRLMLFTG----------------------------------------------QFP-------------- ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Pcla11158034_Pkd2/1-792 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------M-------------------- -------------------------------------------------SN--------------------- ----------PASELER------------------------------------------------------- ------------------------------------------------------------------P----- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------GTNASNRQAWG-GF----------DGRDGA PGPTGPV----------------------------------------------------GAAPTTAVDNY-- ---EYDNSETI------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------RKK---------------- ------------------------------------------------------------------------ ---------------------GCWYNFST------------------------------------------- -----------------------------------------CVS---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------LM--WATRQMTKQEDREVYVR--TT-------LRE LV-----------------------------------------VYVIFLIILCILT-----------Y-GMT SSTMYY------------------------------------------------------------------ --YTNVL------S--GLFL---------------------------------------------------- --------------------------------------------------DTPYPDNQ-------------- ---------GSYRQAT--------LV---------------------------------------------- ------------------------------------------------------------------------ ------------------------------------ADFWTFLE---------------------------- ------NVML------DGLYWESWY----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------DP---------------------------ATTPTE----T------------------------D DRNI---------------------------------LYENR-L--LGLPRMRQI----------------- ------------------------------------------RV------RNDSCTVP---DDF-QRAIRQC ---------------------------------------------FDVYSS--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------SSEDKTPFG--PG--NSSAWIYYTEKQMNSTST--------------- WGKIATY----------------------------------------------------------------- ---------------------------------------SGAG---------SYQDLAL-FRNE-T-----E AIIA----------------DLKENL--------------------------------------WI------ ----------------S-----RGTRAVFIDFTVYNA-NINLFCVIKL--VFEFPA---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------TGGVI--------PSWSFRTVKLLRYVTPMDF--FVMACEF---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------IFIFFIL-YY-------IIEEII-EI--KTI---------------------- GCT-YF-K----------SVWNILDILV-------------------ILISILCVVFSVYCTISIKTKLEEL LADP----------------------------N-------------TFSDFEFLGFWQTQFNTAVAICIFFS WFKLFKYIS----------------------------------------------FNKTMTQ--LFTTLSKC AK-DVAGFTIMFFIVFFAF--SQ-LGYLLF--------------------------G--------------- -------------------------------------------TQIEDFSD-F------------------- --------------------------------------------VS-------------------------- ------------------------------------------------------------------S----- ---------------------VFTLLRLILG-------DFD------------------------------- ---------------FHAI--------------------ENAN--RILGP----IFFISYVFFVFFVLLNMF LAIINDTYTEVK----KEIASQRNEFE------------------------IADYFK--------------- -------------------------------------------RGYNN---------------------MMG KLGK----------------RDKL---------IDLQNAIKLS---------DTNSDGLLTFDEIRANLKKC NFS----------------------DMEIEMFFAK------------------------------------- ------------YDTDGNRLLE-ADEVKRMLADLEGQKMELD------------------------RQMSSE DQPGSKKDSSEAETRPVSAS---------------SGHGSIA------SV-SFEEFSVLQRRVD-------- -------------------------RL------------EHS--IG---------------SIVSKIDA--- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------VLVK----------- ---------------------------------------------------------------LDTMEKTKH --------------------KRRE----------------TMGKILD-------------------TITEND GMDEATKRKHMEKL---------------------------VRDELEKWDGDG------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------SPGS--------------------------------- ------------------------------------------------------------------------ ----------------------------------------------------------GHK----------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Pcla11227996_TRPC/1-1263 ------------------------------------------------------------------------ --MPA------------------------------------------------------------------- ------------------------------------------------------------------------ --------IRGVE---------------------------------ADVEEIKL----------RDS----- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------F SSNSSKAN---------------------------------------------------------------- ----------------------------------------------SIARALKKKI----------S----- ------------------------------------------------LTR--------------------- ----------LTSRTSL-VVD--------------------------------------------------- ---------------------------------------------------------------KDKEE---- ------------------------------------------------------------------------ ------------------RERERRPSRG------------------------------RY-P-----TFTIE DWEEGEH------NGAFREDPAFKDDS--------------RADEKSEFEV---------------DTDVGD DGEAE---------------------------------------------------------GVSLV----- ---DNEDIRSV------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------SSS---------------- ------------------------------------------------------------------------ ---------------------KRTSQLSV------------------------------------------- -----------------------------------------DHS---------------------------- --------MVKCGR----AKFFKRLSVCDLK----------------------------------------- ----------------------------------------------------------------------D- ---------GHMMDPK--ER---------------------------------------------------- -------------------------------------VF--LEAAERGDKHTMMRCL----SPPS------- -----------------------------------------------AVNVNCTDI-----------L-GRS AIQIAV------------------------------------------------------------------ --DNENV------EIVELLLLQ------------------------------------ENV----------- -----------------------------KI-G-----------------DALLYAIT-------------- ---------EGVYKIV--------EMLINH------------------------------------------ ------------PS---------------------------------------------------------- -----------ITP--EMLAN-----------------DWVKVR---------------------------- ------AG---------GE-ESSDFDPNI------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------SPI--------------------------ILAAHC----N------------------------Q FEILQ--------------------------------LFLSR-G--AYIDKPHPL----------------- ------------------------------------------SC------CCRPCTEG-FHADS-LRYSMRR ---------------------------------------------IHTYRALAS------------------ ------------------------------------------------------------------------ PAWISLTSE----------------------------------------------------------DPI-- ------------------------------------------------------------------------ ---LAAFRLSWELERLAR------------------------------------------------------ -----------------------VENEFKDTYL--ELSDQCKKYTCELLHQCRSTQE--------------- VIAVLNRRSE-------------------------------------EDSE--------------------- DDDDEDDP-----------------------------------------QQLKLSRLKLALKYD-Q-----K QFVAHPNCQ-----------QLLTSV--------------------------------------WH------ ----------------EGLPIWRRRNALVKILLCLS--IILCMPIIAI--IYLIFP---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------RTSLG--------RVIRSPFMKFIYHSASFGLFLVLLVLAS--------------TR TEGSER------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------HRR----------------------------------------------------- ------NLRGPAPTFVEWLIFFWVTGMVW---------AECK-QL--WEE---------------------- GLTAYI-R----------QWWNWLDFIM-------------------LSLYLCTFSLRAVAFVQITTNKYG- ---------PREVP-----------------RA-------------QWPANDPTLIAEGVF----AVANVFS FARIIYLFQ----------------------------------------------TNPHLGP--LQISLGCM II-DIAKFLFIFFLVLTSF--ACGLNQLYWYY-DPPSTSCSTVG---------------------------- -GDTT------------------------------------C----HSGSD-A------------------- --------------------------------------------FN-------------------------- ------------------------------------------------------TLDV--------T----- ---------------------FATLFWSLFGISS--PKSTD------------------------------- ---------------LEEE--------------------HGFI--ETVGQ----GLFMAYHVMSIIVLINML IAMMSNSFQQIEDHADQEWKFARSKLW------------------------MSYFDP--------------- --GSTLP-------AP--------------------FNLIISPKAIFYFMRTVKNCLQYI-----------C YRRN----------------RRRSDKR--R-SFTMEKGTLQ-GGAP------PGRMSQSNRYAEVMRRLVS- --------------------------RYIHQTKKQ------------------------------------- ------------HRQDGVNEDD-LLEIKQDISSLRYELREDR------------------------KRETAR AYGQMDS----------------------------IKKDILR---------LLKQSGRTAARSGN------- ------------------------GRE------------TE----G----------------AVGGASA--- --NPV-------------------------------------------------------ALTTSVAPCPAC IHSP---------------------------GVGVTSPCHPSLGTP---------------GIVQQHSVDL- -------------------------------GMLGREPTS-----------------AAVD----------- ---------------------------------------------------------------ITVTPASSL -------PCNL---------TYSQASMGLPSPQ----SLLPVGNLTG--------------------CLLAP QEMDYLRKEIV-SS---------------------------LRSELREMLRDA------------------- ------------------------------------------------------------------------ -----------LSRALTPTTNMAPQ---YYSPT--------------------------------------- ---------PTPNP--------SPQ-YATT---P-TANTAQMAAPQ------FPSPV--------------- ------------------------------------------------------------------------ -----------------------------------AP----------------------------------- --------------------------------------------------------------------QQKQ CSQC----PPAPAS--------SYSPPSP-----TSQPPQHPHLRVSTSLS--------DPFSQRSSSGPQS SSGSSP------------------------------------------------------------------ --------------------------IPQSSP--RSSP--------------------------IPP----- ---------------PCQRSNS-S----------------------------------------------SG L----------TQRSQGISQSGGSSKSPTNQ----------------------------------------- --------------------------------------------------------VL-------------- ----------------------------------------------LRPPNES------------------- ----------------------------------------------------DRV----------------- --------------------------------------------------HTHM----YTQL---------- >Pcla11237310_TRPML2/1-712 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------MNPANH------ ------------------------------------------------------------------------ -----------------------------------------------------------------------G QCHRRRGSRDERVP---------------------------------------------------------- -----------------------------------------------SDETLQQQK---------------- ---------------E-------------------------------------------------------- --------EESAPKSS-------------------------------------------------------- ---------------------------------------------------------------PGQQEQP-- ------------------------------------------------------------------------ ------------------------PGQAAGQSSQGE---------------------GDE-A---------- --------------------------------------L--FRKPHQKSH---------------------- ------------------------------------------------------------------------ --RTMPRRPIS------------------------------------------------------------- ------------------------------------------------------------------------ ----------------------------------------------------ARSK---------------- ------------------------------------------------------------------------ -----------------------------------------------------------RGRS--------- ----------------------------------------GSWS---------------------------- -------GVNESDDELE-----------KMAQAL-GQAV--------------------------------- PEIKV---------------------TTAERN------------------------------GVSHYG---- -------SITSSVNSV-----G-------------STTSTGSTTGLF------------------------- -----------------------------------NADI---------TAERMRRRLK-------------- ---FF--------------------------------------------FMNPMQKWH---------ARRRF PWKLLL------------------------------------------------------------------ -------------QIIKIIIV--------------------------------------------------- --------------------------------T-V---------------QLCLFAHQR------------- ---------YNHVNFLWDTKISFSHLFLQGWDSS-------------------------------------- ------------RE---------------------------------------------------------- -IQAYPPADGALAV-------------------YKKSEFFGYLD---------------------------- ------YAVLMYNNVEKDAIGAYAY----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ KYQNGSIVLPYFCATHYRSG----------------KAFFNN----N---------------SYVLD----D -NTTRSCISIPLLSETNKT-----------EWSMKT-FLIDN-N--FTL----DF----------------- --------------------------------------NILLGAD--------------------LNFVLKT VKLRV-------------------------------------NLPFDTPEC--------------------- ------------------------------------------------------------------------ -------------------------------------------------------------------YEMTS RIV-----------------FSNRD----------------------------------------------- HDGQMVVDLQ-------------------------------------------------------------- -------------------------------------------VGARVLE-CDGSVHVVS-----EAKTLEV WRSVINITTI-------------------------------------------------------------- -------------------AICIT-----------------------------------------SLTMCIR AIYRAQLLRKCTT-------EYFREHRSRELILTEKLEFVNL----------------------WY------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------VLICINDILIII---G-----SFLKIGL--------------------------- ESK---------SYEGYLDTWNVCSLFL-------------------------------------------- -----------------------------------------------------------------GLGNLLV WFGCLRYLG----------------------------------------------FFATYNV--LILTVKKA IP-NVMRFSICLMMVFAGY--CLCGWLVLGPYH--------------------------------------- --------------------------LK--------------------FQS-F------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------SST----- ---------------------MECLFSLINGDDM--FATFSSTSG-R------------------------- ---------------------------------------DPVV--WWFSR----IYFYSFISLFIYVILSLF IAIIMDAYETIK---------------------------------------NYYDDGF-------------- ------P---------------------------------------------ESGLMKFI------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------NEC-TEEPTS------------------------------------------- ------------------------------------------------------------------------ -------------------------AA-----------------FQDEG----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------ERT----------------------- ------------------------------------------------------------------------ ------------IHDIINS----------------------------------------------------- ------------------------------------------------------------------------ ------------FFCCDQE----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------SRRQRGT EYE--------------------------------------------------------------------- ------------------------------------------------------------------------ ---------------A-------------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------------------LLS-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Pcla11240995_TRPA1_like1/1-1150 -----------------------------------------------------------------------M GPMPQ------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------LS------ ----------------------------------------------QGPYVA----------VPM------- -----VPMD-----DTDGKRNNETN-----------------------------------------AL---- VRAVNLK----------------------------------------------------------------- ----------------------------------------------DYQ-LCQKL----------------- -------------------------IEDG-EDVK-----------YINEKDGSTL----------------- --------LHILAKKY---SKRETRAQNIPSLLLQHGA---------------------------------- ----DVNAMNKN---------------------------------------------------GETPLHI-- ------------------------------------------------------------------------ -----------------------------------A-ARE-----------------GLP-D--------FC AILLEQQA-V--------------------------------RVDIKNMKQ--------------------- --------------------------------------------MTPLHFAAQKGELDTLNLLIQK-GANP- ---NIKDS---------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------QKY--------------------------------------------------------- LPLHH---------------------AAEWG-----YHECCKVLASF------------------------- ---------YSVGRT---QDR--------------------------------------------------- -------------------------QD--------IPPV--MLAARKGHYRCYKEMVD-------------- ---A---------------------------------------KANM--NLDYKDG-----------V-GNT ALHITAKLGF-------------------------------------------------------------- ------E------KFVDLLLE-----------------------------TGA------PP----------- -----------------------------DI-Q-----NNVGN-------TPVMEAVI-------------- ---------KNKVNCV--------KELIEN-GAV-VSIKNNAKRSVLHLAAAKKADECMEYLLTI------- -----------------------------------------DRVKDILN----------------------- ----EKDNDGFTAL--------FIAVK---------KHSENCAV---------------------------- ------LLL---------NAGASPSVKSQHKLCL-------------------------------------- ------------------------------------------------------------------------ --------------------------------LHLAAENSKPIFLEKLLAM---------CV------FDVN VTNKDNETPL--------------------------HIAARA----G------------------------S REACQ--------------------------------MLFRK-G--AQVN-AVDK-------NGR------- --------------------------------------TALHIGA------------YHGHSSI-IRLLIKN GAN------------------------------------------KRAKDD-C------------------- --------------------------NST------------------------------------------- --------------------------------------------------------------------ALHA AAA------------------KGNT---------ECCEILTDADKSLYKEQDK------------------- -RKRYALDIA---FLKGHYEVFKLLLQKLPYRNICTMPQDLQEHLHSHTHKALKDRKKTGVEAIVESQWWAA GFGG----------TKKHE--GVPCPNFRDLIK--LY----PFLALKVMDNCTSASDT--------TTSST- ---YYDFRI------------FEDNYC-ITEGKND----LGTSQTSPFDPK-----------TWKVLASAKE LISDTLV----------------------------------------WKQEHPVRI---MVQHR-C-----L DLLQHSLTE-----------AWIQYK--------------------------------------WG------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------S------------------- ---------------YARLL-----------------FTVLFALKAISVVILVSFM-------------INV K-------------------------------------------------NWK------------------- --------------HITDKY-------N---MS------------------EETFCDAV------------- ---------------------------------------------------LKSPTVL-------------- SE--VKAANTTEDTTES--------------LTIRSTNEASEWNPT-------------------------- -----------PSHISHSFLLFSLVLQVF---------LEIN-SA--MK----------------------- LKWHYL-------------------------HSNLIFVRLPC--------IVLTAMLLIPTSY--------- -------------------------------------CDFMLGIKMVPIW--------QCG----ILALLMA WIQLIQIIN----------------------------------------------KLPQCSV--FTISTWDF IK-CYLKGLMYIGMVILLF--ALIFHLLL----------------------QD------------------- --NSA-------------------------------------------FKS-I------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------PQS----- ---------------------FMKTVVWMLGDLG--YDDTFIQ-EP-------------------------- ---------------L------------------------SY---PILVN----VLFFVFICTIGAFIVTLV KAPSSNE-----KEVELFKKAALANYL------------------------LNLDVCF-------------- ------P--------------------------------------WF----------KRKHA---------- --VG-----------------------------------------------------------MYN------ --------------------------VSNRK----------------------------------------- ------------------P-WI-IQKIQH------CIKPKE--------------------SLVVSK----- -------------------------------LSQHIDK-----------VT-LMNTNKFKQDNTKHWIVSKT ----EKLF-----------------RF---FSNYSNEGANIA--LPD------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------LQQEH----------------------------------- ------------------------------------------------------------------LQAQ-- ---------------------TKKLD-----------------QL--------------------LALCNQL ------------------------------------------NENYRKQNEQ-------------------- ------------------------------------------------------------------------ ------------ILEMKQQ----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------LD-------------------------------------------------- ----------------------------------------------------------------------NM KQR--------------------------------------------------------------------- ---------------------------SRYST---------------------------------------- -------------------SPLSF------------------------------------------------ -------------P---------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Pcla11251760_TRPA1/1-1266 -----------------MGMLLQCLGSF-------------------------------------------F HWLRESSTFV-------------------------------------------------------------- ---------------------------------------------------------------------KWL TSGKG-----------------------------------------AS------------------------ ----------------------------TKWWVTTSLRSDD-DSLRCVGFKGDV------------------ ----------------------------------------------IF-----FVKEGNMSNP--------- ----------------------------------------------------------------ASRRGSVS GDGLFHEMA-----EFMGR-----------------------------GRG--------------------- ------------------------------------------------------------------------ ------FTSYDLI-------------------SRTLHQLARDGISEVLNSALDRL----------------- -------------------------GIHGRRRIN-----------NL-DADKLAP----------------- --------LHYAAR---------YAHADAVRLLIHAGA---------------------------------- ----EVNIRGQD---------------------------------------------------KLTPLHYAA RYRKQLKSSRKQSPVPPPPKDEEEEEEEEIGNRGENEENPNGEHESYNLTVGSTQSA------LTIGIGSIS ET--SVIRILVECG----AEVNARDVYDQTP-LHYAAMRG-----------------NVP-A--------AR DLLKCPR--V--------------------------------LCEARDKQK--------------------- --------------------------------------------MTPLFVAATFGYVDISRRLILA-GASI- ---FSKDE---------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------SE----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------Q----------------------------------------------------------- TPLHR---------------------ASMEG-----HLEIVELLLM--------------------SA-VAA GGKATLERLVSERDS---EGQTPL---------HHAVNNSHLQVAR-------------------------- -----------RLLDAGAHLEAVRDTL--------ATPL--HAAAAVGNTDLVKLLLQ-------------- ------KGAR-----LESADCNQ-----------------------------------------------QT PLHRAAAYNQ-------------------------------------------------------------- ------A------PVVTLLLN-----------------------------AGA------SV----------- -----------------------------EK-R-----DTDSF-------TPLLVAAS-------------- ---------GGHAAAV--------QILLSH-GAD-VEAVDKDDKSAVYWCASQGNEEALEVLLS-------- ----------------------------------------DDHCRELVD----------------------- ----VSDRYDNSPL--------HAAAK---------HGYMAIVN---------------------------- ------KLL---------EAGSKVDNKNEDEETA-------------------------------------- ------------------------------------------------------------------------ --------------------------------FHVAAEAGQVRVVRELVNR-------------YK--FLLS DENEYSNTPL--------------------------HLACLQ----G------------------------H TDVAR--------------------------------TLLEA-G--AAVD-ARNS-------SLW------- --------------------------------------TPLDCAS------------AKGHVLC-VHLLLDY DSP------------------------------------------LDPLDK-T------------------- --------------------------RTT------------------------------------------- --------------------------------------------------------------------PLQL AAK------------------EGHV---------AVTRLLLERGASLSA-CDT------------------- -SGRNALELA---ISAG---------------------------------------KRDVCMAIVKSSEWEA GL-----RIVRTDDNGRRV------TPFRMLVK--KF----PDVAEVVLDRCTSTNGM--------DSDDRK FDISFNFEF------------VEDTYT-CHN-GSDT-DSINSISTFEPP----------FDEEGQLAEDAEP YSQDTRE----------------------------------------LKNNHPLML---MVKYK-R-----L NLLAHPVSI-----------SLVKHK--------------------------------------WM------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------S------------------- ---------------YGRFV-----------------YYLTLGFYMIFLIFLTGYI-------------LTA R-------------------------------------------------DWTS------------------ ------------V--ADEMN-------G---TA------------------V-------------------- -----------------------------------------------------NTTVL-------------- IQA-AKQQQSCEDIRKE-VNLTDGV----------------------------------------------- -----------FVIAGKWVIIVLAALNIM---------REMF-QF--YR----------------------- ARLNYIGL----------E--NLIEWCC----------------------YITAVLLVWDFTD--------- -----------------------------------------CPVRQDWQW--------QVG----AASIFLA WMNLLLFIR----------------------------------------------KFPFLGI--YVVMFTDI FA-TFLKFFTVFLLFIVAF--ALGFYTVL----------------------RD------------------- --QDP-------------------------------------------FRT-P------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------ATS----- ---------------------LLKTTVMMIGEME--FDAIF------------------------------- -------ND-ENGQTL------------------------KY---PEITY----ILFVAFLVLMSILIMNLL VGLAVDDIKAVQDQAILKRLAMQTQMV------------------------LDVEALI-------------- ------P------------------------------------ETLK----------RVCIV---------- --CK-----------------------------------------------------------KKV------ --------------------------YPNTY----------------------------------------- ------------------HGSF-SKLLGD------F------------------------------------ ------------------------------------------------------------------------ -------------------------------------NFMNT--FEF------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------FADEE----------------------------------- -----------------------------------------------------------------QMNDQ-- ---------------------ETMRR-----------------DM--------------------TQLMAAV ------------------------------------------E-DLRAQNQR-------------------- ------------------------------------------------------------------------ ------------QRALLIA----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------LMNV------------------------------------------------ --------------------------------------------------------------------SNRN QNR--------------------------------------------------------------------- ---------------------------ETSEP--DITKYV-------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Pcla11260540_Pain2/1-997 ------------------------------------------------------------------------ --MT-------------------------------------------------------------------- ------------------------------------------------------------------------ --GRD------------------TL----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------AARL-------- -------------------------------------------NCCTT------------------------ ------------------------------------------------------------------------ ---SPPLSPAS------------------------------------------------------------- ------------------------------------------------------------------------ --------------------------------------------------TTTTL----------------- ----------APSA---------------------------------------------------------- ----------------------------------------------------------------HNSPVRTA VVRWADKVTP-KGLV---------------------------MVADVENQ---------------------- -----QKTPLMS-A----LEMQELKADDVNALLKRD-EEE-----------------GVR-N--------LV QKWGAN-------------------------------------------------S---------------- ---------------------------------------VW--------------------------RPRL- ---NAEQSA--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------LIT--------------------------------------------------------- TSLHV---------------------AAKEG-----ALKCLRVLLD--------------------AN-PP- ---------KEVLDAP-DQDG--------------------------------------------------- -----------------------------------TTPL--MVAVAEARPRVAEMLLK-------------- --------------------------------------------AGA--HINARND-----------N-GQT VLHILTNITA-------------------------------------------------------KGAK--- -SDEILQ------ELQDLLLS------------------------------HS------DI----------- -----------------------------D--L-----EPHAML------TPLALAASK------------L PQGNGDSRTGGLISLC--------RKLVKA-GAS-LQEDGGDG--------------SIEEILHQ-----KQ AFHAVLMGG------------------------ERMSAPKRPARSQFLDMIFMGKGSEDIKIFLENQSDEER HAAANCRLGQQTLL--------FRAVD---------LKNEDLVQ---------------------------- ------VLI---------KFGANPWALG-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---ARNELPI--------------------------HRAASR----GHVSIFNHIIDKMKGGTKPVDFQDYT FSIIQ--------------------------------KLMES-DKKQKNI-HPDI----------------- -----------------------------------------------------------SHSKC-LQRLMQD DVI------------------------------------------LNINQEYM------------------- --------------------------GQT------------------------------------------- --------------------------------------------------------------------ALHV AAS-----------------FNNQE----------AMSELLCKGAFLGA---------------HSTLPGN- -HHSSILDSL-------------------------------------------------------------- ----------------------------------------LPATLERAMNGCIKHHPANNEISESNNVLSED YMLKLDYRF--------------------------------------------------------------- LVPPADD-----------------------------------SLKKEQKSINETETLMDISRSKRH-----R HAIKHPLVQ-----------ILLYAK--------------------------------------WR------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------K------------------- ----------------ALPL-----------------YLLNLGIYFFFVILLTAFV-------------YSI K-------------------------------------------------DLRIL----------------- -EAQAES------YLNSGSS-------N---RT---IDDLNSGSSNRTI---DDL----------------- ------------------------------------------------------------------------ -----NSGSSNKTIDERIE--------------------------NKQ----VTVN---------------- --------------VLMAFLLPITIYIFI---------REVF-QI--VF----------------------- SRDVYL-K----------NIENYLEW-F----------------------LVVVVIVLCSTNL--------- -------AADVT-------------------------------------R--------HLA----AWAMIVA WYEFVLILG----------------------------------------------RAPPLAI--YITMLRHV SW-NFLKLIFLYGALLLAF--TISFNIIL----------------------QP------------------- --APAD--------------------------------------EDTDFRD-F------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------WST----- ---------------------LPKAIVMATGEFE--YSDLSQH----------------------------- ----------FSRRIV-------------------------F---FTSAL----LVFLLFLFLIFLVLMNVM NGLAVTDTQKVVEDAMLYSLTSRLELV------------------------YLIESFFLTCPGLQSHI---- -------------------------------------------NRVQ------------------------- -----LLS----------------------------GAKYTPI--------------------LYA------ --------------------------QMNKPIKKQ------RLL--------SG------------------ -------------KHKEFQSKL-DDYSAE-CLRN-HRQ-------------------------QILE-E--- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------ENQQ--------------------GREDP---------- ---------------------------------------------------------------LSQYLPV-- ------------------------LQ-----------------EL--------------------------- ------------------------------------------QVILSNNPQ--------------------- ------------------------------------------------------------------------ -----------ILHSGR------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Pcla11299325_Iav/1-1148 ------------------------------------------------------------------------ ----MGAC---------------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------------------ATK------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------KEPINP------ ------------------------------------------------------------------------ ----------------------------------------------------------------GSAL---- DRVISQAS---------------------------------------------------------------- ----------------------------------------------SDDCVLYRLA---------------- ------------------------DYKKGGRLIEE------------------------------------- --------YNRGGG---------------------------------------------------------- ------KEVERL------------------------------------------------------------ ------------------------------------------ILEEFGIF---------------------- --------------------------------LYNH---------------------GRG-M-----DITRT EYLKWKYRKV------------------------------------PKDQMVVQM----------------- --------------------------------------------------------------------ERK- ---SPFDPL--------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------HR----------------- --------------------------------------------WKD------------------------- -------------------------------------------------------------HE--------- ----------------------------------------ACWQ---------------------------- ---------MQFRGSLG-------------------E----------------------------------- TLLHV-------------------------------------LIMC-------------------------- ------------------------------------------------------------------------ -----------------------------------DTKA--HTR-------VAKILLR-------------- ---CF---------------------------------------PKLAVDVVEGEEYL-----------GAS ALHLAI------------------------------------------------------------------ --AYSN------NELVTILVA-----------------------------AGA------DFTQRAVGSFFLP KDQQVTCPP-----------------GPEN--T-----DYEGLAY--LGEYPLSWAAC-------------- ---------LGNETVY--------NKLLDF-GAD-------------------------------------- ------------PN---------------------------------------------------------- ----AQDSFGNMIL--------HMVVV---------CNQLGMFS---------------------------- ------YALR------HPRLPAQDGIMN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---LAGLTPL--------------------------TLACRL----A------------------------R STIFK--------------------------------EMLEL---------TCIE-------FWRY------ --------------------------------------SNITCSA--------------------------- -------------------------------------------YPLNALDTIRP------------------ -------------------------SGET------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -NWNSALMII-------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ LNGTKSE----------------------------------------------------------H-----L DMLEGGIIQ-----------RLLEEK--------------------------------------WK------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------T------------------- ---------------FARNQ-----------------FLKRLAIMLLQLILLSVAV-------------YLR PCYCGP----------------------------------------------K------------------- -NMQR----------------------N---KPEIR------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------KMLYD--------EFFDND-- -----------FKSI---ARYCFEGGTLA---------GVIS-YV-VFQQ--------GEE-------IMNQ GLSSFM-R----------GLAGNAPKAI----------------------FMVANLLIMLVVPCRIVYFFK- -------------------------PEMLVLRA--------------LED--------ELL----SYAVAGS WFMLMFFAG----------------------------------------------ALKLTGP-FVVMIYKMI TG-DMFTFSIIYFIMLLGF--SEAFYFLY----------------------KSP------------------ KYDKD-----------------------------------------SKYAS-Y------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------GTT----- ---------------------WMALFHMTLGDYD--YAGMNLN----------------------------- ----------------------------------------IY---SAMSK----FVFLVFTIMLPIMLLNML IAMMGNTYSTVISMSEKEWVKAWAKIV------------------------IALERAISQEKAKDYLY---- --MYSLPIGGGGD------------------------GGEESLGVMVI---------KSKDK---------- -TKA----------------KQRKGA----------LSNWKRV------------------GRVTIDALQRR GVSGEFLRREMWGLQTAAS-------TPVKGPAKKKGYGGL----------LGTETGPATGDILGDALNQTM FA-TD--SVDPNDEMDGFG-AL-TGAIDQ-LAFT-HDLDF--------------------------SGDGVD DDPLKP----------------------------NM-VGQAP------------------------------ ------------NTLAPPAHLPVVPER---KKK-KKRRDSEG--YDNPAFLD-------DEELLLASALG-- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------GGDSDDS-----------------DTDMLE---------- ---------------------------------------------------------------ARRLSKP-- --------------RIIIQ--AETET----------------ASV--------------------TTTSGAK AAAAPATGKAP---------------------------VAAASKTPKAPVKPEVA---------EVPA---- ------------------------------IMPRPRL----------------------------------- --------TSAKMRRIGSAR---------KTPARFA------------------------------------ MTFTEKY--DPVGK---------------VDAVK-VPVTTKSQAT-----THDQKP---------------- -------------------------------EVCEK-KDNRKGKK--------------------------- ---------------SEE--AVPAAPEDA------------------------------------------- -------------------SVD-------------------------------------------------- ------------------------------------DNGE-KWAEKK-------------------PRRSKN KVG------------------------------------PSSS----------------------------- ---------------------------SEESA--SGADQQTQD-DLSVGL--------------QSG-SDST ---------------R-DEVRA-------------------------------------------------- -------------KEKERPKTSVASQ---------------------------------------------- ----------------------------------------------------KMKKR--------------- --------------------------------------------------ATENVGNMNS------------ ------------------------------------------------------------------------ ----------ILPWDNDDGDIK-------------------------------------------------- >Pcla11321145_TRPA5-1/1-1047 -------------------MARRLDSKR-------------------------------------------- -IMKHLFS---------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------KRPFF------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------KNR-SVVEECTDT-------------- ---------------------------------------------SDNSRSRLTLNG--------------- ------GS--------------CRGRCTLLP----------------------------------------- -----GLEEGDA---------------------------------------------------GATGYGPRT ------------------------------------------------------------------------ -------------------------------------MTCP----------------GIG-EGPPP------ ------------------------------------------------------------------------ -------------------------------------------------------------------ASLV- ---EESDLH--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------DCM--------------------------------------------------------- PLIFV---------------------AIKTG-----DIQKVQELLKEDP-----------------EA-AS- ------------------GAR------------------------------------YGG------------ -----------------------------------CSPL--HAACSLQRLHILTELLN-------------- --------------------------------------------YDA--KVGAVNG-----------L-GYT ALHLAVCEGW-------------------------------------------------------------- ------H------QGVALLLQ-----------------------------HGA------SPNTVSD------ -----------------------------PP-L-----TVKGV----RVETPLHCAVR-------------- ---------RGDLASV--------VLMLQH-QAD-LTLRDGDNCSVLHLAAMSRSLEVTRQLLQE------- -----------------------------------------KLNHRLVT----------------------- ----VSDNDGNTAL--------HKALL-MDCDTAEESTVHEIVE---------------------------- ------ELV---------KAGANVNATN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---KWKESPL--------------------------FLAARH----R------------------------L PKLVA--------------------------------LLLSL-G--ADPT-LLTH-------RGQ------- --------------------------------------SVLHAVC------------RRGCAAC-LARLLAT NLVN---------------------------------------ELVTAADK-E------------------- --------------------------GRE------------------------------------------- --------------------------------------------------------------------PFHY AVH------------------SGSI---------DCCELLLNHGDHLTR-VDR------------------- -DGTSRCSLI-------------------------------------------------------------- -------------------------------LE--HLP-SATQLLRRLFDAHIRLSNN--------PQHEVD FRVTFDYSV--------------------------------------------------------------- LSLEEEG--------------------------------------------EQGSLISDLSNSR------LE ALLKHPLLE-----------SFLFIK--------------------------------------WR------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------K------------------- ----------------IKPF-----------------FYCSVLIYFMFLMMHTTFI-------------I-- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----ITYGGNSLRWRDNAD----------------------------------------------------- -----------SLAIFFVLHVTMFLLILI---------PDMI-IM--FA----------------------- NFKKYI-R----------QWETLTKIIA----------------------LGSSAVVMFSHIIPFYSEGEVL ED---LQANIMENDTVEELNTTGNFMQNGTLST-SSEHDSHSQVEVPLLR--------RAA----AISAFFC WVELMMLLG----------------------------------------------RFPSLGT--YVLMFSRV AK-SIIKFIAAFFSLIIGF--SISFMVLF----------------------HN------------------- --KEA-------------------------------------------FRS-F------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------PLS----- ---------------------LVKTLMMMIGEIE--YSALLDD----------------------------- ---------------------------------------IEM---PLMSC----LFLVLFLFLVCVLMANLL IGLAVNDIPDLQRQGKIKRLSKQASYL------------------------VSYEKLMLIARVLRCF----- ------P------------------------------------RQLRV---------FMSSR---------- --CR-----------------------------------------------------IPQ--VVHV------ --------------------------LPNKHRKS--SHKN-------------------------------- -------------VELYVPSET-LQEAIL-LGNF---------------------------DDSNENIANLE EDNLL----------------------------AQFRS---------------------------------- ------------------------FKVKYTHDLRAMNRRLGQ--LPD------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------SAATEK---------------------------------- ------------------------------------------------------------------IVKE-- ----------------RLDQSVQIMQT----------------QL--------------------LQL---- ------------------------------------------SLQLQQLNQNY---------------NYMQ HLAAGQQQH--------------------------------------------------------------- ------LLTAEQQQQLTAEQQQQQQ----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------QQQQQQL---------------------------------------------- --------PHQPI-----------HTQSAFQQSVQPQSLPQQSVYTRSVYQ-----QSLPAHSLPTASVQTQ SLF--------------------------------------------------------------------- ---------------------------QQTSY--TA----------------------------------SQ ---------------H-HSSN--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Pcla11323207_TRPMc/1-1314 -----------------------MVGGG--------------------------------DVAEAGRVVLAE AKMGSWER---------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --SMSTH----------------------------------------------------------------- --------------------------------------------------LTVDLS-LPPV----------- ------------------------DDHNTGDQSTTT---------RTDTEPWDEISIR-------------- -----KISPE-------------------------------------------------------------- ---QERPSKDEQ---------------------------------------TDDYP-AF------------- ------------------------------------------VLKHFCRK------------------ECIR F-------------------------------MGTNNVEKDGPCCC-----------GLMMTKHQATLIPAS ---QAPSPHEG------------------------------------------------------------- --------------------------------------------------------------FRSVTPSLD- ---LGPDP---------------------------------------------------------------- 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----FYTSPISKLCAHSSA--------YGGFLVLYT--------------YVVLFDFKY------------- -----------EMSVSEMVLIIWMFTFFS---------DEFV-EI--GSE--------TLP-------TVRE QLANWA-S----------SVWNKFDLVL----------------------VLMGSLAFCLRLFRETF----- ----------------------------------------------SWGR--------MAY----SINTALF YCRFFRIYY----------------------------------------------ASTHLGP--KLFILYKT IP-EVVVFMALLVIFLLGF--GIASQALM-----------------------------------H------- PARDA---------------------LH--------------------LNS-S------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------ALG----- -----AIMEQV----------LLTPYWQMFGELQ--LQEIAGEDRVVCH----------------------- ----------QNSCIMGELC-DNGTTNCRPELDCVCENPNNY---TWIVL----IMLSCYLIIGNVMLLNLL IAIFMDVYETVQKESKEISRFQMLVLV------------------------REYDQ---------------- -RSALIP------------------------------------PFVVI---------QHLFR---------- IFQK-IRK------------PQIQPET------------------------------CED-TEETL------ --------------------------EERNKLKEELLKKYEEVAASSGA----------------------- ------------CTTHSLVKVI-SHKLDK------------------------------LSEYLKRDDDQED DDAD--------------------------------------------------EDDEDEDDEDED------ -----------------------------DEDEDDEDEENNK--NGDTLT----------NEI--------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------ETSGSQSTLKEEPADECVDLSQHKQSDEADA---------- ---------------------------------------------------------------AEQVKEENY W-------------PSHLAELNTRFD-----------------TLD-------------------KTL---- ---------------------------------------NTRLDTLDQQLRHT------------------- ------------------------------------------------------------------------ ---------HHLISKMMST----------------------------------------------------- ------------------------------------------------------------------------ ------------F----------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------DKTIGN KKE--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Pcla11697014_Nan/1-444 ------------------------------------------------------------------------ --MGNTESSV-------------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------------------TSG------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------VKAQA------- ------------------------------------------------------------------------ --------------------------------------------------------------NA-V------ ------------------------------------------------------------------------ -------------------------------------------------VEIYSLV---------------- ------------------------DLNGGGELVEL------------------------------------- --------MKKANKTK-------------------------------------------------------- ----DFSELDET------------------------------------------------------------ ------------------------------------------IRSKIPKY---------------------- --------------------------------IYNG---------------------GEG-K-----CLPIH QLVLRRNKER-------------------------------------PPSKEITPP---------------- --------------------------------------------------------------------KVL- -----PD----------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------EE----------------- --------------------------------------------SVA-GRY-----------LPRKMEPDRA A--------------------------------DFTTY-----------------------RY--------- ----------------------------------------VCWD---------------------------- ---------LKHVGAVG-------------------E----------------------------------- TVLHL-------------------------------------CVLN-------------------------- ------------------------------------------------------------------------ -----------------------------------ATSV--HND-------LAKRLIR-------------- ---HF---------------------------------------PNLINDIYLCDEYY-----------GEN VLHISI------------------------------------------------------------------ --VNED------PAMVKFLLD-----------------------------NGA------NYHERCLGNFMCP EDQKTSRCDS---------LDHEWVDLCLP--T-----NYEGYVY--WGEYPLSFAAC-------------- ---------LGQEECY--------RLILAK-GAN-------------------------------------- ------------PD---------------------------------------------------------- ----MQDTNGNTVT--------HMMVI---------YDKMDMFD---------------------------- ------MCF---------EAGASISIRN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---RQGLIPM--------------------------TLAAIL----A------------------------H RDIFF--------------------------------HILNI---------EREI-------YWQI------ --------------------------------------GNITCAA--------------------------- -------------------------------------------YPLDYLDTINV------------------ ------------------------NTGET------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -QTKSALNLI-------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ AYGDKEA----------------------------------------------------------H-----L DLMEG-PIV-----------DLLKTK--------------------------------------WE------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------T------------------- ---------------FVKNR-----------------FNNLFFVFLTYFLISMGAY-------------VNR PV---PCVTSTPIPLSK-RPLS-------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Pcla11781006_TRPA1_like/1-578 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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KLKNPK------------------------------------------FRPQPLYACNAMVESG-R-----V DLLMHPLTQ-----------TFLEMK--------------------------------------WQ------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------A------------------- ---------------YGKYI-----------------HLSNLFVYLVFLFLVTVFA-------------VGI LG---------------------------------------------NN-SAVS------------------ ------------A----------------------------------------------------------- ------------------------------------------------------------------------ --Y-VNAS-HHFDYNNT-TDDFDRY-------------VYEVTENTG------------------------- -----------WMYCMGVAILVLSGLSMI---------KEMI-QF--YH----------------------- HRLKYL-L----------EPINVVEWTL----------------------YLTSVCMVLPVFL--------- -----------------------------------------GTGWRAQQF--------NSA----SLAVFTA WFTLLLYFQ----------------------------------------------RFDRIGI--YIVMFLEI LN-TLLKVLLVFSVLIVAF--GLAFYILM----------------------SH------------------- GGYLS-------------------------------------------FSN-V------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------AMS----- ---------------------MLHTFSMMLGEVD--FLTIFVYPFYQ------------ESVR--------- ------GDR------L------------------------LF---PRTTF----ILLVLFMILMPILLMNLL IGLAVGDIESVKKNAQLKRIAMQVELH------------------------TELENKL-------------- ------P------------------------------------EVLI----------QRVNK---------- --SE-----------------------------------------------------------LLV------ --------------------------YPNYC-GG-------------------------------------- ------------------TRIL-HRILSA------FNFACP------------------------------- ----------------------------------------------------MSDKGYAD------------ ----------------------------------MEGTESVG--RDD------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------YLWEE----------------------------------- ------------------------------------------------------------------LEGQ-- ---------------------RKRLR-----------------DI--------------------SAT---- ---------------------------------------------LDQQTKL-------------------- ------------------------------------------------------------------------ ------------LRLIMQK----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------MEIK------------------------------------------------ --------------------------------------------------------------------SEAD ECD--------------------------------------------------------------------- ---------------------------EGVSL--DDIT---------------------------------- ------------------RQPRTS------------------------------------------------ -------------HGFPST-SASSRKT--------------------------------------------- ----------------------------------------------------LLAKRD-------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Pcla1554562_NompC/1-463 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------MVRILVEAGS---------------------------------- ----NTDAQNSA---------------------------------------------------GQTPLHIAA ---------------------------------EEGDEP--------------------------------- -----TVKFFYTVH----ANPNIMDKFDRTP-IHVA-AEN-----------------GFT-P--------VV DLLAEKYK-A--------------------------------SVMDRTKDG--------------------- --------------------------------------------STLVHIASLHGHPDTVMAFLRK-GVPL- ---HMPNK---------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------SGA--------------------------------------------------------- RCIHT---------------------AAQRG-----HVGVVNAILH--------------------KG-EH- ---------VDVTTN---DGYSAL---------HIAVKAGKPAMVEALLGHGADLTMQGGTGRESALHLAAR VKD--GEKCAEMLLKSGADANLPKDDG--------QTPL--HLAAYNGNLKTLKLLLED----DSAKPLIQS K-------AGETSLHLACSSCRV---EAAKMLIEHVLKKSGKEAVAK--MVNTKNN-----------L-GET ALHYAGRVNK------------------------------------------------------KNATY--- -KAGEDR------EMANLLLT-----------------------------NGA------HLMVVTTKNSETP IHYVSTSGNQAVLDEMLQFAPQDKVQKLVNM-Q-----STKGW-------SPLLNAAE-------------- ---------NGHEGIV--------ATLLDH-HAR-VDVFDSEGKAALHLAAERGYKLVCDALLTH------- --------------------------------------------KAFVN----------------------- ----ARSMSGLTAL--------HLAAM---------KGYNELVR---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ >Pcla1592729_NompC/1-470 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ 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------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------G------------------- ---------------SLDWP-----------------AWKMVMMFFAFLFLPPVWI-------------FFS M----------------------------------------------------------------------- --------------PLGHMY-------N---EV--------------------------------------- ------------------------------------------------------------------------ ----------------------------------------------------PIVKFI-------------- -----------AYLVSHLYLLMLMIISVV---------TPLS-PI--WEN--------TN------------ -------L----------IP-NWYEWLLLLWLSGNLVMELTNPGDIAGLGWIKVFVLVFSGLGILVHLVGFF ---------YLG-------------------------DTELIPEMLYIRN--------NFL----AIATLLA SVQLLDFLS----------------------------------------------FHHLFGP--WAVIIGKL MV-DLGRFLVILAIFVFGF--SMYVAAI-------------------------------------------- --YNP------------------------------------------------------------------- ------------------------------------------------------------------------ --IRPIYSE--------------------------------------------LNMTSE----------NTG YPPAEAPIQ----------------TPLQTGEML--FFSLF------------------GLVE--------- ------PDY-MPPFY-------------------------SH---PSWSQSLMKIVFGIYQMVTVVVLINLL IAMMSDTYQRIQAKS-------------------------------------DTEWKF-------------- ------GL-----------------------------------AKLI----------RNMSR---------- --TS-----------------------------------------------------------GTP------ --------------------------SPLNL----------------------------------------- -----------------LVKLI-VYIVAV------FKFKCN---------------------LCSDK----- -------------------------------AMEYMRT-----------EGRPEDPHQADLK---------- --------------------------------TEFGGGWIKK--LRS------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------RSKAS----------------------------------- ------------------------------------------------------------------IMPQ-- -------------------------------------------ST--------------------ENLVP-- ---------------------------------------------LSNMEGS-------------QGVRRIE NVIK------------------------WSRV---------------------------------------- ---------VNRYRIMHRK----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------EVQP------------------------------------------------ --------------------------------------------------------------------GEEA --N--------------------------------------------------------------------- ---------------------------PELPT--DS----------------------------------VE ---------------D-LQNEAML------------------------------------------------ -------------NGGVE-NSEQSSTA--------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Pcla1637789_Nan2/1-548 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------W------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------RE--------- ----------------------------------------VAWR---------------------------- ---------AGW-GSRS-------------------R----------------------------------- ---------------------------------------NITCVNV-------------------------- ------------------------------------------------------------------------ -----------------------------------SIHL--HPDV-----IIEDPTIT-------------- ---TD---------------------------------------PTSLIDILTAPTVN-----------LTQ GFDLNLDIATSTS-------------------------------------------------SSNVTLQ--- -PEEEEAEDDFLPLLL-------------------------------------------------------- ---------G---------TQAEVVTQLPDD-A-----VTVQYVV--EGE---PVSVT-------------- ---------LGSELND--------LLTASV-TSD-------------------------------------- ------------PL---------------------------------------------------------- ----SEDPTTRPPL---------LFTC---------YNK--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------THHLNL----M------------------------A QNLTF--------------------------------FITKI---------IKRA-------KWMKP----- --------------------------------------PVAMLAV--------------------------- -------------------------------------------NPYEVNTTTNA------------------ -------------------------SAPD------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -PCYCTL----------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------WK------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------I------------------- ------------------------------------------------------------------------ PK---P--------------------------------------------------------------NRKR -EMMI------------------------------------------------------------------- ------------------------------------------------FGMY-------------------- ------TSEI-------------------------------------------------------------- ---------------YFYVRVVCEGLTFL---------GSLA-YL--VGA--------ANE-------GRFQ GAQMFV-E----------NLSTVPSRVL----------------------FLLACIMVMVMGALRAL----- -----------------------------CMNE--------------AED--------LVA----VMVMLCT GPYFLFFCR----------------------------------------------GFKTVGP-FVTMIYTML VG-DLLRFVTIYFVFIMGF--SQAYYIIF----------------------SSF------------------ QDL---------------EDKSQC--------------------TSNPMPT-A------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------AES----- ---------------------VMQMFIMSLGNFGDIYSALECT----------------------------- ----------------------------------------DH---EITGK----VLFMIFMAIVSLLLINLL IAMMGNTYER-IAEMKNEWMRQWARIV------------------------LVVERGLSPEERLKHLM---- --TYSQPMSDGRR-----------------------------ALVLRL---------HQE-D---------- -EER----------------EEMKDI-----------MDMKRV------------------HQKYVLRRKNR KNPFD------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------ETVDVA----------------------------------------------- ------------------------------------------------------------------PKPVPK E----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------PPKKA------------------------------------------------------- >Pcla171849_TRPML1/1-763 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------MNPANH------ ------------------------------------------------------------------------ -----------------------------------------------------------------------G QCHIRRGSRDERVP---------------------------------------------------------- -----------------------------------------------ADE-IPQQE---------------- ---------------E-------------------------------------------------------- --------EESAAMSS-------------------------------------------------------- ---------------------------------------------------------------PGQRQQPR- ------------------------------------------QAGGHPSQGEGDPSQGEGDPSQGEGDPSQG EGNPSQSEGDPSQGEGNPSQGEGNPSQGEGDPSQGE---------------------GDQ------------ -----------------------------------------FRKPHQKSH---------------------- ------------------------------------------------------------------------ --RTMPRRPIS------------------------------------------------------------- ------------------------------------------------------------------------ ----------------------------------------------------ACSK---------------- ------------------------------------------------------------------------ -----------------------------------------------------------RGRS--------- ----------------------------------------GSWS---------------------------- -------RVNDSNDELE-----------KMTQAL-GQAV--------------------------------- PEIKV---------------------STAQRN------------------------------GCSLYG---- -------SITSSVNSV-----G-------------STTSTGSTTGLF------------------------- -----------------------------------NTDI---------ATDRMRCRLK-------------- ---FF--------------------------------------------FMNPVQKWS---------ARRRF PWKFLL------------------------------------------------------------------ -------------QIIKIVVV--------------------------------------------------- --------------------------------T-V---------------QLCLFAHQR------------- ---------CTHINFLWDTQISFSHLFLQGWDSS-------------------------------------- ------------RE---------------------------------------------------------- -IKVYPPTDGALAV-------------------YTKSEFFGYLD---------------------------- ------YAVLMYNNVEKDAIGAYVY----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ KHQNGSTVLPYFCATHYPSG----------------KAFLYN----N---------------SYVLD----D -NTTRSCISIP-ISETIKT-----------DWSMKT-FLIDN-N--FAL----DF----------------- --------------------------------------DILLGAD--------------------LNFVLKT VKLRV-------------------------------------NLPFDTPEC--------------------- ------------------------------------------------------------------------ -------------------------------------------------------------------YEMTS RIL-----------------FSNRD----------------------------------------------- HDGQMVVDLQ-------------------------------------------------------------- -------------------------------------------VGALVLE-CDGSVQVVS-----DAKMLEV WRSVINITTI-------------------------------------------------------------- -------------------AICIT-----------------------------------------SLTMCIR AIYRAQLLRKCTA-------EYFQEHRSRELTLGEKLEFVNL----------------------WY------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------VLICINDILIII---G-----SFLKIGL--------------------------- ESK---------SYEGYLDTWNVCSLFL-------------------------------------------- -----------------------------------------------------------------GLGNLLV WFGCLRYLG----------------------------------------------FFTTYNV--LILTVKKA IP-NVMRFSICLMMVFAGY--CLCGWLVLSPYH--------------------------------------- --------------------------LK--------------------FQS-F------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------SST----- ---------------------MECLYSLINGDDM--FATFSSTSG-K------------------------- ---------------------------------------DPVV--WWFSR----LYLYSFISLFIYVILSLF IAIIMDAYETIK---------------------------------------NYYNDGF-------------- ------P---------------------------------------------ESGLMKFI------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------NEC-IEEPTS------------------------------------------- ------------------------------------------------------------------------ -------------------------SA-----------------FQDEG----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------ERT----------------------- ------------------------------------------------------------------------ ------------IHDTINS----------------------------------------------------- ------------------------------------------------------------------------ ------------FFCCDHE----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------SRRQRDT ECE--------------------------------------------------------------------- ------------------------------------------------------------------------ ---------------A-------------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------------------FLS-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Pcla1749782_TRPA5-2/1-935 --------------------MSRLLGCF-------------------------------------------- -AHS-------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------TRPL-------- -------------------------------------------PVD-HT----------------------- -----------------TE------------------------------------------------I---- ANSISKHPQQEALNLH-------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------------------LGSVSSHKDL----------------- ---------ETPSLHQ------------------------------------------QG------------ ------------------------------------------------------------------------ ----------TSNIH---------------------------KEHKQEQ----------------------- ---------------------------------------------------------TTL-KYAQQRQQGIL NRPQQE-----------------------------------ISITHKQKQEGRC-P---------------- -------------------------------------------------------------------EHKK- ---RAITPF--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------RNFI-------------------------------------------------------- RRLAG---------------------RASTSTK--SSNRSTNTTKS--------------------SN-RS- ---------TNTTKS---SNKSTN---------TTKSSNRSTTTTK-------------------------- --------------SSNRSTNTTKSSNRSTNITPTIIMI--NPGMV-----------T-------------- --------------------------------------------EGS--NNGVGDA-G--FCAWD--P-NAA RLLKMVDNEN-------------------------------------------------------------- ------L------EGLQALLE-----------------------------GGI------HV----------- -----------------------------NG-H------------------------G-------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------GSFHETAL--------HRAAQ---------ICWATGVR---------------------------- ------YLL---------SAGASVYAKN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---QFGQTPL--------------------------HYAAAS----K------------------------S TACIK--------------------------------LLLE--S--GRPG-VLDH-------RD-------- ----MRGH------------------------------TPLHDAS------------ASGCVNA-ITTLLKA GAL------------------------------------------IRAKDG-N------------------- --------------------------GET------------------------------------------- --------------------------------------------------------------------PLHK AA------------------RAQSI---------PAMLALLNAGADMSA-CDS------------------- -NGESVLSYT-------------------------------------------------------------- -------------------------------LH--HFP-G---TMDAVFDYCLVTNSP--------RMNTKT LEVTMNFLP--------------------------------------------------------------- LTCS--------------------------------------------EDKNQVQNLQSFVGLG-H-----A KLLSHPLCE-----------TFLLLK--------------------------------------WM------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------N------------------- ----------------VRRL-----------------FLIEVILYVLFAVVTTLLT-------------FNK F-------------------------------------------------VWK------------------- ----------------NVSS-------N---NT---SRPM--------------GC---------------- ------------------------------------------------------------------------ ----GGR-----ELNESKVDKKFSIV---------------NIPDEGV----RALQ---------------- -----------------GIVITYLVAILI---------QQFL-SL--LQ----------------------- NKMAWF-R----------SLSGVLHVII----------------------TILVMSVVLPPE---------- -------------------------------------------PH-KWQH--------HLA----SCLMLLM WTECMLLIG----------------------------------------------RFPNCGI--YVVMFTRV AK-VFLRIFLIYFCLLLAF--SAAFYVTL----------------------H-------------------- --DPETD--------------TTL------------------GEKNVVFSN-P------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------IFT----- ---------------------FIKTLTMMIGELD--FDDNFVCGLNN------------------------- -----------------------------------------L---YVTGQ----AIFVLFVILVSIILSNLL VALAVNDVQGLRNSAHLERLIKQTELV------------------------FHMEKNFS------------- -----------------------------------------IAAYIA----------NYVK----------- ------IPTLCD-----------------------MLMKIANVCNY----DCYNTR-------VYI------ --------------------------LPNNPKKFN------KLFIMQNKKY--------------------- -------------NETTLPSHL-VTHV--------NQC-------------------------LRTRETE-- -------------------------------TSDNKSS-------------TRTKRGSRIRRGEFHRN--AD EDIKSNIK-----------------EL---------EANMIE--IVS------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------EKME--------------------DMADT---------- ---------------------------------------------------------------HSLLNKR-- ------------------------IT-----------------AL--------------------------- ------------------------------------------EEKLDKVVS--------------------- ------------------------------------------------------------------------ -----------LLLKNDGDNA--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------PAD KIP--------------------------------------------------------------------- ---------------------------LSDEG--T------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >Pcla185101_TRPM/1-1743 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------MAGPR-------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------WVETIFNKRE----------CIK--- ---------------------------------------------FIPSSK-DNA----------------- --RCCCGQLWQCHRDGS-PATLRHGE---------------------------------------------- --DVHWSPSRHT---------------------------------------------------QLLPTDAYG TLEFQGGAHP--------------------------------TKAQYVR----------------------- ------------------LAHDTRPDHILQL-LTGE--------WGLDLPKLLITVQGGK-T-----NFDLQ PKLKK---------------------------------VIRKGLLKAAKTT--------------------- -----------------------------------GAWVFTAGTNTGV---------------TRQVGEAL- ---VSESSLRV------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------RSG---------------- ------------------------------------------------------------------------ ----------------------RVVSVGI------------------------------------------- ----------------------------------------APWG---------------------------- --------IIERRQEL-------------IG-----RN---------------------------------- KDVPY----HPIN--------------SPKSKFVALNSHHTFFLLVDNG-------------TVGKYG-PE- ---------LILRRKL--EH-------------YISKQRIEARGGL-------------------------- -----------------------------------ATPV--VCVVIEGGPQTIRQVLE--YVTDSP------ -----------------------------------------------PVPVIVCDG-----------T-GRA ADILAFVHKYASSG-------LNMIEANRDTILLALERVFELRPLQAEK-------------LFAEILQ--- --CVRKR------DLITVFRLK----------------------------------EGSEL----------- -----------------------------DQ-S-I--------------LSALLHAQR-------------- ---------LNPPE----------QLSL-------------------------------------------- ------------------------------------------------------------------------ ------------AL------------------------TWNRVD---------------------------- ------IA------------RSHVFIEDVEWS---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------QGAL----------------------EQAMMDALVN----D------------------------R IEFVK--------------------------------LLLEQ-G--VTMNKFLSI--------QKL------ --------------------------------------EELYNS-------------KCGPSNT-LRYIIRD --------------------VKK-NIPRDYRYTLIDIGLVVNKLMGGAYRSYYT-----------RKKFRTV YENTMMKSP------------RLLRNNSSI-----------------------------------------F QASKSLL-----------------------------------QKNYNSSPKSYLSQGDMYSKFEFD-YPFSE LLVWAV--------------LTKRQ---------GMAMLMWQHGEEAIA----------------------- -KALVAAKLFKALAHEAADD---------------------------------------------------- ----------------------DLETEVYEELK--GYAKEFETLALEVLDFCYQQDDD-------------R AHQLLTYELR-------------------------------------------------------------- -------------------------------------------------NWSKQTCLSLAVAVN-H-----R ALLSHTCCQ-----------ILLADL--------------------------------------WL------ ----------------GGLR--TRKNTNIKVM------LSLLFPLLVP--LLGFR----------------- -SREELKTMPQTREEHQYD-------------DPERSSGSESDTESEEDNLD-------------------- --MR-HDHDP---------------------EAPLCNSNTNAPHSSTLLAPPPQHE-NSDTVDGH------G TPVRQNGVSM---------------------SHVSHLDSNIFNDL------------------------HSK QLPAR-----------TKFY--------EFYNAPISKFWAHSMAYVFFLCLYTYVV-------------LVK LPM--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------KPDWMEWYVIAYISTLIL---------EKIR-EI--LST----EPI-----------ELRQ KIAVWS-D----------KLWNVCDMTF-------------------AVLFMIGMTLRLQ------------ -------------------------------------------------EQT-MQTGRIIY----CVDIIYW YLRILEILS----------------------------------------------ANKYLGP--LVMMMGKM IK-NMAYFVVLLLVVLMAF--GVCRQSILFPN-------------------EE------------------- -------------------------------------------PHWRLARH--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------I----- ---------------------FYQPYFMLYGEVF--ADDID---------------PDCGG----------- -------E-GEIP-CHPGR---------------------------WITP----TVMSMYLLVANILLINLL IAVFNNIFISVNSISRQVWMFQRFQVV------------------------MEFEGK--------------- ---PVFP-------PP--------------------LIIISHIHRIIK----------YCFR---------- --RW----------------KGKP---------FLYDNGLKIFLDG------ESLERLHDFEEECMDGYNR- -------------------------EKEQKEQMST------------------------------------- ------------EERVRVMAER-TEGLTQRIEDMHTKFVAAMT----------------SVNNLDFHVKRLE ETVEQTKNSYAVVHRFMLSHVG----------HKRSTSPCSG------SGTPHSEGGGCASRSVSQTSL--- ------------------------HRM------------LEE--TSQQ--------------MSRRLT---- -------------------------------------------------PEPE-------VSEKEM------ ---------------------------------------SD------------------------------- ----------------------------------TYDAEHE-S-------------QKHLK-------SS-- ----SKVLCFGEPLKTSSPTGT------------MEVFKL---------DSISS----------VNTRRTKA ---------------QNR-RSKQRLD-----------SESGSSLGH------------------------AS RERKLS------------------------GG---------KKSSIRNST-KHSDVIK-------------- ---------------------------------------------------AFSPSK--------------- ------VCF----RDIDIEDDSDSG--EGDPGTRK--------------------------------LSAE- EEMHLRYIRAITSPVVEAAVLHSPP-KYERSL-S-TSS---------------CRPRIQ------------- ------------------------------------------------------------------------ ----------------------------------VIPPTS-------------------PPPIFT------- -------------FTSEYTSLADE---------------------------------------------LET VCMSRLSPPSSP------------HLHYAGR---VVPQLRQHHCSDSV--------PISITVSS----NPLR DAEEADYQLMEGLIQRRMHRDSENLAVSLEDLCSVRTDVSDSEDGIN----------------------PLS IR---------RDSRATE--------LRKRHS--TTSID--------------------------------- -----NNPSELLSV-P-GSVQL-SSLQTIN--------QLYHSS---------------------SLCG-KG -----------TRLASSQPGSPSARRSSLCED--------------------IHIQWASSGALPVFGEWLTP RSSP----------RPCSPPFV----------------------------QPQTTSVY-------------- ----------------------------------------------TTP-TDSASQSRDLQPSM-------- ------------------------------------------------------------------------ -------ATLQVPV----------------------------VSETEGR-PKDII---TETEC--------- >Pcla1876279_TRPgamma/1-1081 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------MGE-------------------------ED---------------------------------- RHNR------------------------PH---------------------------------------QE- ---------MGQLTIE--EK---------------------------------------------------- -------------------------------------KF--LLSVERGDVAGVRRMLL--RSRES------- ---------------------------------------------GCMMNINCVDP-----------L-GRS ALLMAI------------------------------------------------------------------ --DNENL------EMVELLI-E------------------------------------FKV----------- -----------------------------ET-K-----------------DALLHAIS-------------- ---------EEYVEAV--------EVLLDH------------------------------------------ ------------EE---------------------------------------------------------- ------------TV--------HIPGEPH---------SWEAIP---------------------------- ------P-------------ETATFTPDI------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------TPL--------------------------VLAAHR----D------------------------N YEIIK--------------------------------ILLDR-G--ATLPGPHDL----------------- ------------------------------------------RC------GCDECVTS-RLEDS-LRHSRSR ---------------------------------------------INAYRALAS------------------ ------------------------------------------------------------------------ PSLIALSSK----------------------------------------------------------DPI-- ------------------------------------------------------------------------ ---LTAFELSWELRRLSF------------------------------------------------------ -----------------------MEHEFRSEYQ--ELRKQCQDFATALLDHTRSSYE--------------- LEVLLNH-----------------------------------------D----------------------- --PTG-PP-------------------------------HEHG------ERMHLNRLKLAIKLK-Q-----K KFVAHPNVQ-----------QLLASI--------------------------------------WY------ ----------------EGLPGFRRKNMALQALQIVK--IGILFPIFSV--VYILAP---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------HTTPG--------QTMRKPFIKFICHSASYLTFLCLLILAS--------------QR IETVIV--------------------------------------------DW--F----------------- ---------------------------G-------------------------------------------- ------------------------------------------------------------------------ ----ATPT-LKKWVATDVT----------------------------------------------------- ------TRRGAPPSLVEWLILAWVFGLIW---------SEIK-QL--WDV---------------------- GLREYV-G----------DMWNVIDFIT-------------------NALYVATIALRIVAYYQVQREIREN LSTE-------NLP-----------------RQ-------------EWDTWDPMLIAEGLF----AAANIFS SLKLVYIFS----------------------------------------------VNPYLGP--LQVSLSRM VV-DILKFIFLYLLTLFAF--SCGMNQLLWFYADLEKQTCDELG-LNPE----------GEDETG------- PKIDS------------------------------------C-IVWRRFSN-L------------------- --------------------------------------------FE-------------------------- ------------------------------------------------------------------T----- ---------------------TQTLFWAAFGLID--LTNFE------------------------------- ---------------LTGI--------------------KPFT--RFWGM----LMFGTYSVINVIVLLNLL IAMMNHSYQLVSERADTEWKFARSKLW------------------------ISFFEE--------------- --GGTCP-------PP--------------------FNIIPTPKSLYY-------LFHWFYK-------KFC GQTK----------------AAKK----------EHMRTIRRKA--------RQASERELRYQNIMRNLVR- --------------------------RYVTVEQRK------------------------------------- ------------AENQGVTEDD-VNEIKQDISAFRCELVEIL------------------------KNSGMN TSTATS-----------------------------TGQG------------TGGKKNRQKER---------- -------------------------RL------------MKG--FN-----------------LG------- ----VNSIS---------------------------------SNLS--------------LGTSTVL----- ----------------------------------------PPTVEV------------AEVAVKRSPQ---- ---------------------------------------NKLA--------------RLAR----------- ---------------------------------------------------------------LAEARLGRP --------------------TNKK----------------RWGTL-----------------------VEAA K-NAKVKKLL--SR---------------------------SRSDESL------------------------ ------------------------------------------------------------------------ --------------SSDPGNEMNGD--SEDARG--------------------------------------- ---------GTDTP---------------------------------------------------------- ------------------------------------------------------------------------ ------------------------T-----------PLQ---------------------------SLP--- ---PGILR----GGDGSSEGTRRER---SGSR--------------------------------------GS GT---------------------------------MHLDAAALVSQHET---------T-KRPP-KNSVSFD QSA--------------------------------------------------------------------- --------------------------LAGASS--S------------------------------SP----- ------------------SHSS-TETEPPP-----------------------------------------P Y----------PQWPR----------PVPTA-------SNL------------------------------- --------------------------------------------------TET------------------- -----------------------------------------------NPTATSPSSGGSGSLPPLAVSESSE PLVS--------GGPP-------ANGSV-QPPRL----------------------PG-------------- ----------IQPVNRH--------------------------------------------MAAGWL----- >Pcla1923526_TRPA1-like2/1-1178 ---------------------------M-------------------------------------------A TTTDKSQ----------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------IPLLQ------ ----------------------------------------------KVSRKA----------LKKQKRIVKD GTHV-VNID-----DISKHHTKTRP-----------------------------------------HY---- ERAVSVRERYDRVG-DPINA---------------------------------------------------- --------------------------------HTYTEELLQKAEGNDFD-ACQNL----------------- -------------------------LEKG-AIVN-----------IEDEKTKLTA----------------- --------LHIAAK---------NGQHDILNLLLTKGA---------------------------------- ----DCNAQDNT---------------------------------------------------GHSPLHLAV ------------------------------------------TKDYPFC----------------------- -----CEILLKCTD----LKVNIQNKTLDTP-LHRA-AKE-----------------GRI-H--------IC TMILQHNN-I--------------------------------EINVRNDKG--------------------- --------------------------------------------MSPLHLATLENHAEVIKLLIEN-GADC- ---KMQDK---------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------YFH--------------------------------------------------------- LPLHY---------------------AAQKG-----FPECCEVLLSI------------------------- ---------CSDADK---EKQLTV---------VL------------------------------------- ------------------------KDR--------KTPL--MLAAKGGHHKCCAKL---------------- --------------------------------------------GNT--SINAVDK-----------E-GNT ALHYAAIGGF-------------------------------------------------------------- ------E------NTIELLLT-----------------------------MGA------EP----------- -----------------------------NT-Q-----NKKRK-------APVHEAAG-------------- ---------KKKSSCL--------KLLKDN-CAK-FDVVDEQNRTVLHYAAEKNAEDCLQYLLSL------- -----------------------------------------PDLK-ILD----------------------- ----KKDKERCTAL--------HIAIK---------RESVECAH---------------------------- ------ILL---------KSGASPIEQCIGKMTP-------------------------------------- ------------------------------------------------------------------------ --------------------------------LHLAADKGYTSLCEVLLAK---------DI------VQVS QENGKKATPL--------------------------HLAALH----G------------------------S VDVCQ--------------------------------MLLRK-G--ARLS-AVDT-------NGR------- --------------------------------------TALHIAA------------NKGCGSV-VKFLTKK GIT------------------------------------------QRTKDD-T------------------- --------------------------GST------------------------------------------- --------------------------------------------------------------------ALHL AAS------------------EGSL---------ECCQLLVASAKATCNDIDH------------------- -NGKLPFDRA---FEKKHDSVFRFLLLQLPYKK---DEEKRMACLHEYINIALEENRLTVVEAIIDSSWWQA GFRS----------KNEHH-----CQNFRQLVE--YH----PGLALKVQDKCVDRSKS--------KTI--- ----YDFRF------------YEDNYY-IPTAS-------SKTDESPFESE-----------SGKVHQNAQT FTQDDLE----------------------------------------WKNRHPLTL---MVSHS-R-----H QLLKHSLTN-----------AWLLHK--------------------------------------WR------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------S------------------- ---------------YIYLI-----------------FLALLLLELLFVGCLMAFM-------------GST D-------------------------------------------------NWS------------------- --------------HIETRC-------N---LT------------------REQFCRLSET----------- ------------------------------------------------WQEMKEPTST-------------- PDTLIEGS-LSKEISEN--------------FTLLPD------NSTG-----SKLQFMKC------------ ------NEAVPVKHGVFVCLLIITSITLL---------LECN-YM--YR----------------------- LRNEYL-------------------------SFNNL-MQICR--------LIFSIIIIVPRGR--------- -------------------------------------CEFDHHILYVEHW--------QCG----ILALLVA WLHLINMLN----------------------------------------------QLPMLSV--FMPITQSF LK-SFFKVVFYIAMLIFIF--AFIFHLLL----------------------RD------------------- --QTA-------------------------------------------FFT-V------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------PQA----- ---------------------MVKTIVWMLGDLA--YDDTFLNDDHQ------------------------- ---------------L------------------------VY---PVMVN----LLFVVFVTTIGGFIVNLV ITQPSEKLDSFRDKAVFYRAASRCTLF------------------------LKLEICF-------------- ------P--------------------------------------FF----------RKYRT---------- --RG-----------------------------------------------------------TY------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------VDEETEVNGY-NVLTK- -----KLL-----------------LL---DSKED---AETE--PTN------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------PLQLQ----------------------------------- ------------------------------------------------------------------LENQ-- ---------------------HQQIN-----------------TL--------------------LTL---- ---------------------------------------------HMEQREE-------------------- ------------------------------------------------------------------------ ------------IRDLKHT----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------LNLM------------------------------------------------ --------------------------------------------------------------------AKSL PGL--------------------------------------------------------------------- ---------------------------NQSQ----------------------------------------- ---------------------LKI------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >PhIav/1-1055 ------------------------------------------------------------------------ --MGAGLC---------------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------------------GTS------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------QDPQNQ------ ------------------------------------------------------------------------ ----------------------------------------------------------------GSVL---- DRVISQAS---------------------------------------------------------------- ---------------------------------------------NKDDCLLYKLA---------------- ------------------------NYKNSGELIEA------------------------------------- --------YNIGGQ---------------------------------------------------------- ------AEVEKL------------------------------------------------------------ ------------------------------------------IKEQFGVL---------------------- --------------------------------MYAD---------------------GKG-E-----VIKRA EYLRWKFRD--------------------------------------QAQVVLPIE---------------- --------------------------------------------------------------------ASL- ---SIYDPL--------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------AK----------------- --------------------------------------------WED------------------------- -------------------------------------------------------------HE--------- ----------------------------------------ACWQ---------------------------- ---------MQYRGSLG-------------------E----------------------------------- TLLHV-------------------------------------LIIC-------------------------- ------------------------------------------------------------------------ -----------------------------------DSKI--HTK-------LARTLLK-------------- ---CF---------------------------------------PKLALDIVEGEEYL-----------GAS ALHLAI------------------------------------------------------------------ --AYNN------NELVEDLVD-----------------------------AGA------NINQRAVGSFFLP KDQQRAKP-------------------LKT--T-----DYEGLAY--LGEYPLSWAAC-------------- ---------CSNESVY--------NLLLDV-GAD-------------------------------------- ------------PD---------------------------------------------------------- ----SQDSFGNMIL--------HMVVV---------CDKLDMFG---------------------------- ------YALR------HPKVPASNGIIN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---NEGLTPL--------------------------TLACKL----G------------------------R ADVFK--------------------------------EMLEL---------SAKE-------FWRY------ --------------------------------------SNITCSA--------------------------- -------------------------------------------YPLNALDTLLP------------------ -------------------------DGRT------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -NWNSAIFII-------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ LNGTKEE----------------------------------------------------------H-----L DMLDGGIIQ-----------RLLEEK--------------------------------------WK------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------T------------------- ---------------FARNQ-----------------FLKRLVIFFLHIFCLSGSV-------------YLR PD---------------------------------------------------------------------- -------------------------------DRNKP------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------LL-----------GGTS-- -----------VQDV---VRYCFEIGTIL---------GVLC-YL-CFQQ--------GDE-------IRNQ GLISFL-K----------QLPHDPAKFI----------------------FLISNLLILACIPYRVA----- -----------------------------GDTD--------------TEE--------AIL----VFAVPSS WFLLMFFAG----------------------------------------------AIRLTGP-FVTMIYSMI TG-DMLTFGIIYSVFLFGF--SQSFFFLY----------------------KGS------------------ KNVSS-----------------------------------------SLFTS-Y------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------PST----- ---------------------WMALFQVTMGDYN--YNDLSLT----------------------------- ----------------------------------------AY---PAISK----MVFTIFMVLVPILLLNML IAMMGNTYAHVIEQSEKEWMKQWAKIV------------------------VALERAVNQEDCHRYLQ---- --EYSIKLGPGDD------------------------PSTEQRGVLVI---------KSKSK---------- -TRA----------------KQRKGA----------LCNWKRV------------------GKVTIRELHKR GMTGEQLRRLMWG-RSSIS-------TPVKPAPIKLGH-------VTSISGVADITVPETTG---------- ------------NTVGTGGGGL-LAALDV-MAFT-NDLEF-------------------------------- ----SSENQTSTS----------------------FKTQPQP------SEVSCVESDSNS------------ ----------------------------------------------DPL----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------YNDP---------------------------------- ---------------------------------------------------------------LRQLNEE-- --------------------LNKTRE-----------------EI--------------------LTLARVA ANNDGI------EE----IPPQICQYGWI-NNYNFFGNTFAQNQKVEDPVQQPTF---------QSTPNHSD ----SDGLG------------------DGLLLGS-------------------------------------- ---------NRRLKRTRSAN----------IKRKFS------------------------------------ GSSTNEK--NLLEP------------EDSSSTNS-ED----------------------------------- ----------------------------------------------------FSCLTENYINKNI------- ------------------------------------------------------------------------ -------------------KVNAN------------------------------------------------ ---------------------------------FSENSL-----RS--------------------NRSSAN --------------------------------LVVKK----------------FGRRSGLKS---------- ------------------------------------STNR------------------------IAP-ADLS ---------------P-------------------------------------------------------- ------------------------------------------------------------------------ --------------------------------------------------VGNVSKYSETLCN----SYCIT SSS----------DV---------------LYQW----------------SIKGITNMNT------------ ------------------------------------------------------------------------ ----------LLGLENEDSM---------------------------------------------------- >PhNan/1-823 ------------------------------------------------------------------------ --MGNTESNV-------------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------------------TSG------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------VKKQA------- ------------------------------------------------------------------------ --------------------------------------------------------------GTSE------ ------------------------------------------------------------------------ -------------------------------------------------QPLYKLV---------------- ------------------------GLKGGGLLVDM------------------------------------- --------MKRATQTK-------------------------------------------------------- ----QYAELDHA------------------------------------------------------------ ------------------------------------------IKTKIEPF---------------------- --------------------------------LYNK---------------------GKG-R-----LIPIS QLVLLRNCER-------------------------------------SRTKLLPLL---------------- --------------------------------------------------------------------KNM- ---EDPE----------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------SE----------------- --------------------------------------------FDM-DRDGNPGDF---QPAPDGVQEDFH D--------------------------------YNKKY-----------------------RD--------- ----------------------------------------VCWD---------------------------- ---------LKKRGAVG-------------------E----------------------------------- TCLHL-------------------------------------CMLN-------------------------- ------------------------------------------------------------------------ -----------------------------------ATSI--HAD-------LAKRLLK-------------- ---FY---------------------------------------PKLINDIYMSDEYY-----------GES VLHVAI------------------------------------------------------------------ --VNED------PAMVKYLLD-----------------------------SGS------NFHERCFGNFMCP EDQKATRTDS---------LDHEYVNLSTE--T-----NYEGYVY--WGEYPLSFAAC-------------- ---------LGQEESY--------RLMLAK-GAN-------------------------------------- ------------PD---------------------------------------------------------- ----NQDTNGNTVL--------HMLVI---------HNKLPMFD---------------------------- ------VAY---------EVGANLSLKN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---AKCLTPL--------------------------TLAAKL----A------------------------R VELFF--------------------------------HILNI---------EREI-------YWQI------ --------------------------------------GSITCAA--------------------------- -------------------------------------------YPLSQIDTIDI------------------ ------------------------ETGNI------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -SKNSALNLV-------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ VFGEKDE----------------------------------------------------------H-----L ELMDG-VLV-----------DLLVAK--------------------------------------WN------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------T------------------- ---------------YVKFR-----------------FYRQFISFFFYFLISVICF-------------TLR PG---P-------------PTG-------TTTTTN------------------------------------G -IVVL-----------NNNN-------N---NIT------------SVVDNSNNVTTTTATTTATSYSFPG- -------------------------------------------------------HVI-------------- ---------------------------------------------------VTLLS-------YDKYEDK-- ------------------IRIISELAMEI---------GSVL-YL--LGA--------LRE-------AKFL GIHMFI-E----------NLMTAPSRVL----------------------FLGSCCIMQFVPWLRIT----- -----------------------------CKEE--------------TED--------IVA----VIIMLTT APYFLFFCR------------------------------------------------KMNDP-VFLFLFFLI KK-------IFFLIFFFFFFTKPTYYIIF----------------------LSF------------------ DNPKT------------PDGVDDS--------------------GTNPMQS-P------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------VES----- ---------------------IMAMFLMSLTNFGEYYGAFEKT----------------------------- ----------------------------------------EH---EFVAK----LMFVVYMAIVAILLVNML IAMMGNTYQK-IAETRNEWQRQWARIV------------------------LVVERGVSPQERLKKLM---- --LYSQPMSDGRR-----------------------------ALVLRL---------HQT-P---------- -EDK----------------EEMKEI-----------LDMKRI------------------HNRTVQRRKAK ENKNV------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------TFAGTP----------------------------------------------- ------------------------------------------------------------------KNGIKN RLL--------------------------------------------------------------------- ---------------------------GPVP----------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------PLKSIPSKPK-------------------I------------------------------ >PhNompC/1-1719 ------------------------------------------------------------------------ --MSGT------------------------------------------------------------------ ------------------------------------------------------------------------ -GGRKGGGG--------------------------------------G------------------------ --------------------------------GGGKKKEDGN-----NESKEDDTGSGN------------- ---------GDKKDSNVK-------------NDKTS--------------------NNGDVKP--------- ----------------------------------------------GSAGVS----------IREGSHR-LL ALAMRGEWP-----PVDQVLKAIEKAVAAGG-DDVNSTPLSGVVDPITGMTPLMYAVKDNR---TTFI---- DRMIELGVDVAARNFDNYNALHIASMHS----REDVIKLLLSKKGVDVYVTGGMKEQTAVHMVATRQTGTAT SILRILLNAAGKEIRLRTD-------------GKGKIPLLLAVESGNQS-MCREL--L-------------- -------------------------GSQAADQLR-----------AT-TPDGDTA----------------- --------LHLATR---------RRDIDMVRILVDYGA---------------------------------- ----AIDLQNGD---------------------------------------------------GQTALHIAA ---------------------------------AEGDEV--------------------------------- -----LVKYFYGVR----ASASIVDNQDRTP-MHLA-AEY-----------------GHA-N--------II ELLADKFK-A--------------------------------SIFERTKDG--------------------- --------------------------------------------STLMHIASLNGHSECAQMLFKK-GVYL- ---HMPNK---------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------DGA--------------------------------------------------------- RSIHT---------------------AARYG-----HVGIINTLLQ--------------------KG-EK- ---------VDVTTN---ENYTAL---------HIAVESCKPLVVETLLGYGADVHITGGSHKETPLHIASR VKD--GDRCALMLLKSGAGPNITTEDG--------ETSV--HVAAKYGNATTLSLLLE-----DNGDPLFRN K-------LGETPLHLACRGCKS---DVVKLLIDFVREKKGPEVATS--YINAVND-----------N-GAS ALHYAAKVSK-------------------------------------------------------TEVE--- -RPLEDQ------EVVRLLLE-----------------------------SGA------NSSLMTKHALETA FHYCAEAGNNDVMTEMISQMNATDVQKALNK-Q-----SAVGW-------TPLLIACH-------------- ---------KGHMELV--------NNLLAN-HAR-VDVFDLEGRSALHLAAEKGYIEVCDALLTN------- --------------------------------------------KAFIN----------------------- ----SKSRVGRTAL--------HLAAM---------NGYADLVSFLIKEHNAMIDVLTLRKQTPLHLAAAAG QIEVCKLLL---------ELGASIDATDDLGQKPIHVAALNNYSDVVQLFLQ---HYPSVVTASTKDGNTCA HIAAIQGSVAVLEELMKFDRQGVIAARNKITEATPLQLAAEGGHADVVKMLVRAGASCTDENKAGFTAVHLA AQNGHGQVLEV-MR--SSQSLRVSSKKLGVTALHVAAYFGQADTVRELLTYVPATVKSDPPS---GVGLVEE LGAESGMTPL--------------------------HLASYS----G------------------------N ENVVR--------------------------------LLLNSAG--VQVDAATTE-------NGY------- --------------------------------------NSLHLAC------------FGGHITV-VGLLLSR SAD-----------------------------------------MLQSADH-H------------------- --------------------------GKT------------------------------------------- --------------------------------------------------------------------GLHI AAT------------------HGHY---------QMVEVLLGQGAEINA-TDK------------------- -NGWTPLHCA---ARAG---------------------------------------YLSVVRLLVESGASPK SETNYGSPAIWFAASEGHN------DVLEYLMT--KE----HDTYSLMEDK--------------------- ---RFVYNL------------MICG----KNNKNRPIEEFILVSPAPVDTA-AKLSAILVNLATKEKERSKD LVEAGKQC-----------------EAMATELLALAAGADSAGRILTALDRRNIEFLDVLIENE-Q-----K EVIAHTVVQ-----------RYLQEL--------------------------------------WK------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------G------------------- ---------------NLMWS-----------------AWRLMFLFLLFIICPPIWV-------------FFT L----------------------------------------------------------------------- --------------PLGHSF-------Y---KV--------------------------------------- ------------------------------------------------------------------------ ----------------------------------------------------PIIKFM-------------- -----------SYLTSHIYLMLFLMLVGI---------TPIY-PV--VRN---------T------------ -------L----------LP-YWYEWTLLVWLSGLLLNELTNPSDKSGLGWIKLAVLLFGIFGVALHLLGL- ----------FI-------------------------DRPYWPTLMYLRN--------QLF----ALSFLLA CVQILDFLS----------------------------------------------FHYLFGP--WAIIIGNL MK-DLARFLAVLAIFVFGF--SMHIVAL-------------------------------------------- --NQP-------------------------------------------FR---------------------- ------------------------------------------------------------------------ ------------------------------------------------------NLTPQ-----QVQ-ANVK PHPYQGLFG------------EVRMNPLMAFELL--FFAVF------------------GQTT--------- ------PQN-LQGTT-------------------------IQ---PWWTLILFKITGGIYMLVSVVVLINLL IAMMSDTYQRIQAQS-------------------------------------DIEWKY-------------- ------GL-----------------------------------AKLI----------RNMHR---------- --TT-----------------------------------------------------------TTP------ --------------------------SPINL----------------------------------------- -----------------MTTWL-IILLRF------CKQKV-----------------------IQRK----- -------------------------------RPSLVQM-----------MG-LQSRSRVSPR---------- --------------------------------TKVATKWLAK--VKK------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------GQ----------------------------------- ------------------------------------------------------------------VAPK-- ---------------------DPVAL-----------------SV--------------------VHLSP-- ---------------------------------------------LGSQMSF-------------GNATRIE NVAD------------------------WEAI---------------------------------------- ---------AKKYRALMGE----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------SSED------------------------------------------------ --------------------------------------------------------------------RMGK DTN--------------------------------------------------------------------- ---------------------------QQDVT--SSTIT------------------------------LLE ---------------N-NNNNNNN------------------------------------------------ -------------NSNNNNNNATS------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >PhPHUM001594-PA/1-1158 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------M-------------------- -------------------------------------------------KV--------------------- ----------TESREEL-FKK--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------SIEDL------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------EDS---------------- ------------------------------------------------------------------------ ---------------------C-------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------D---------------------------------- YNLS------------------------AL---------------------------------------AE- ----------TFLTPT--EK---------------------------------------------------- -------------------------------------KF--LLCAEKGDIPTLRSLLI--QFED-------- --------------------------------------------RPDELNINCTDS-----------L-RRS ALVTAI------------------------------------------------------------------ --ENENM------DLIKFLL-K------------------------------------SNI----------- -----------------------------KV-K-----------------DALLHAIK-------------- ---------EEFVEAV--------EVLLEW------------------------------------------ ------------EE---------------------------------------------------------- ------------KI--------HVDGEPY---------SWEAVD---------------------------- ------S-------------ASATFTPDI------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------TPL--------------------------ILAAHT----N------------------------N YEILK--------------------------------ILLDR-G--ATLPRPHNV----------------- ------------------------------------------RC------GCDECLAS-SEADS-LRHSQAR ---------------------------------------------INAYKALSS------------------ ------------------------------------------------------------------------ SSLISLSSR----------------------------------------------------------DPL-- ------------------------------------------------------------------------ ---LTAFELSWELKNLSY------------------------------------------------------ -----------------------CEAEYRSEYN--EMRQATQDFATALLDHARTSGE--------------- LEVMLNY-----------------------------------------N----------------------- --PNG-DI-------------------------------WEPG------ERHTLERLKLAIKYK-Q-----K KFVAHPNVQ-----------QLLASI--------------------------------------WY------ ----------------DGLPGFRRKSTVRQITDVLK--LACLFPFYSC--IYMIAP---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------NSKMG--------LFVKKPFVKFIFHSSSYAFFLLLLGLAS--------------QR AENTFL--------------------------------------------ELLAM----------------- ---------------------------E-------------------------------------------- ------------------------------------------------------------------------ ------IEWLHDVLAEWKR----------------------------------------------------- ------KERGSWPGVVESALYLYIISLIY---------SEVR-AL--WTN---------------------- GLKEYM-A----------DLWNIVDFIT-------------------NCFYLVWIGLRFTAIYIVMRESNL- GLDP-------YIP-----------------RE-------------QWHPFDPMLLSEGAF----AGGMILS FLKLVHVFS----------------------------------------------VNPHLGP--LQISLGRM II-DILKFFFIYMLVLVAF--GCGINQLLWYYSNLEKVKCFGED-------GT------LEPDFD------- NNEKA------------------------------------C-TVWRRFAN-L------------------- --------------------------------------------FE-------------------------- ------------------------------------------------------------------T----- ---------------------SQSLFWASFGLVD--LTSFD------------------------------- ---------------LVGI--------------------NSFT--RFWSL----LLFGCYSVINIIVLLNML IAMMSNSYQIISERSDIEWKFARSHLW------------------------MSYFDD--------------- --GDTLP-------PP--------------------FNLLPTMKTLL----------------------RIF KTEK-----------------------------NLTADSFKVK----------SMDKARKRHELVMNNLIA- --------------------------RYVTAEQRK------------------------------------- ------------RCDYGITEDD-VIEIRQDISSLRYELVHIL------------------------RANGMK TPEMN------------------------------PDQNL-----------V-TKKGKIMER---------- -------------------------RL------------EKD--FR-----------------IGIVEG--- ------------------------------------------------------------IIHEFL------ ------------------------------------------------------------------SS---- ----------------------------------DKDSLDIFG--------------KIAK----------- ---------------------------------------------------------------VFNRKRN-K --------------------SKKQ----------------DWNTI--------------------------V R-KSSYQKNLI-GS---------------------------SEERRERLAKQS------------------- ------------------------------------------------------------------------ -----------VRRYIIEKLSS-SE--ALDPEK--------------------------------------- ---------LVQYN---------PQ-LLQM------APAARIAYTK------FSRIKITREF---------- -------------------------------AEQEKIINEEIEEEKH---------AEELVK---------- ------LTHSSTERKKDE--EQPPNDTTDF--SIVRPRPQ-----SRS-----------NSKLMKL------ ------------ISIPSKEGTETKDCIIKMSEEDEN-ETIVTVENEI----KQEKKTSSIS-----IQSPPS LNDVI------PT---------VVSIESP-----LKDVKKFEPVAAIIR---------QMSIK--------- --S--------------------------------------------------------------------- --------------------------ITTSPV--QK------------------------------S----- ---------------P-PTDEM-TPPT--------------------------------------------- -------------------PPIPIIKKPEMKTDENEENNKF------------------------------- --------------------------------------------------TSLDIKGS-------------- ----------------------------------------------RSPLADSS------------------ ------------------------------------------------------------------------ ------------------------------------------------RGRSKV----TGEIISGWL----- >PhPHUM003044-PA/1-971 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------MSVN---------------------- -----------------------------------YLDMEEG------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------RL-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------PQAPL---- ------------------------------------------------------------------------ ------------------SYIPKDP----------------------------------------------- --------------------------------------------DKS------------------------- ------------------------------------------------------------------------ ----NYKNKVK------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------RHS---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------IHG---------------------------- --------MME-------------------------EE---------------------------------- NVVR------------------------PH---------------------------------------QE- ---------MAQLSLD--EK---------------------------------------------------- -------------------------------------KF--LLAVERGDVASTRRTLQ--KAQET------- ---------------------------------------------D-FININCVDP-----------L-GRS ALLMAI------------------------------------------------------------------ --DNENL------EMVELLI-E------------------------------------HKV----------- -----------------------------ET-K-----------------DALLHAIS-------------- ---------EEFVEAV--------EVLLDH------------------------------------------ ------------EK---------------------------------------------------------- ------------TI--------HKPGEPH---------SWEALP---------------------------- ------P-------------DTATFTPDI------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------TPL--------------------------ILAAHR----D------------------------N YEIIK--------------------------------ILLDR-G--ATLPDPHHV----------------- ------------------------------------------RC------GCKECVTS-RQEDS-LRHSRSR ---------------------------------------------INAYRALAS------------------ ------------------------------------------------------------------------ PSLIALSSK----------------------------------------------------------DPI-- ------------------------------------------------------------------------ ---LTAFELSWELRRLSF------------------------------------------------------ -----------------------LEHEFKIQYQIKTRSKQCQDFATALLDHTRSSYE--------------- LEVLLNH-----------------------------------------D----------------------- --PTG-PA-------------------------------FEHG------ERMHLN----------------- -FVAHPNVQ-----------QLLASI--------------------------------------WY------ ----------------EGLPGFRRKNMILQAMEIVR--IGILFPFFSL--MYILAP---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------HSKIG--------QTMRKPFIKFICNSASYLTFLFLLILAS--------------QR IETVVG--------------------------------------------DL--F----------------- ---------------------------G-------------------------------------------- ------------------------------------------------------------------------ ----LTND-GMK--APDIT----------------------------------------------------- ------TKRGALPSIIEWLILFWVAGLIW---------SEIK-QL--WDV---------------------- GLEEYV-H----------DMWNVIDFVT-------------------MSLYVATVALRIVAYYRVQKEISEG TGSN---RLYIELQ-----------------RE-------------EWDTWDPMLIAEGLF----SAANIFS SLKLVYIFS----------------------------------------------VNPYLGP--LQVSLSRM VL-DIMKFFFLYVLVLFAF--SCGLNQLLWYYADMEKKKCVPEY-DLGK--NMTK-------NLS------- SDRTA------------------------------------C-LVWRRFSN-L------------------- --------------------------------------------FE-------------------------- ------------------------------------------------------------------T----- ---------------------TQTLFWAVFGLID--LDSFE------------------------------- ---------------LEGI--------------------KTFT--RFWGM----LMFGTYSVINIVVLLNLL IAMMNHSYQLISERADVEWKFARSKLW------------------------ISYFEE--------------- --GGTVP-------PP--------------------FNIIPTFKSMWY-------LSQWLYR-------KLC GHSR----------------AAKK----------EHMRTIR----------------------SIMRNLVR- --------------------------RYVTVEQRK------------------------------------- ------------AESQGVTEDD-VNEIKQDISAFRCELIEIL------------------------KNSGMN TSTASG-----------------------------MGAG------------SGGKKNRQKER---------- -------------------------RL------------MKG--FN-----------------IAPTPGPGV PLAPVAEFI---------------------------------ANLQAEPEILQ----HQDLFGSTISGIIG- ---------------------------------------TPNTVP------------------KKSNQLR-- --------------------------------ESMHDAPSSAPP----------Y-VQTGS----------- ---------------------------------------------------------------LSTSLPSQK S-LSKLTPKFN---ISKRSSSRKK----------------RWGTL-----------------------MEAA K-SGKVSKLI--NR---------------------------SRSEDS------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------V------------------------------- --------------------------------------------------CNS------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >PhPHUM009153-PA/1-1143 ------------------------------------------------------------------------ --MAT-------------------------------------------------------------NPH--- ------------------------------------------------------------------------ ---RDRKGSRSHE--------------------------------HRDRDPREI----------TDRVYE-- -------------------------------EDNAEERERELFWNNNT------------------------ --------------------------------------------------------PNAQQNPKNTFAPD-- ---------------------------------------------DRGSRFL--------------IR-ERE YYTVH---DDP---ETQRRRQQEEP---------------------------------------GEVIH-NV DNNRRRASRTEPENVE-------------------------------------------------------- ---------------------------------------------PHFNPNLRQDS----------S----- ------------------------------------------------KNF--------------------- ----------NKNRREF-TTDERNSKGEVEHHY---------------S----------------HYQNRSR EGPLNRREPHHE---------------------------------------------------QEIPPD--- ---FN--------------------------------------EKGYFDPFKENHKR------Q----GSLH GRSPMATTPLPDINH--DAPLPPIPKYSRK----------------YGSPERIPE--KTY-S-----KNDLH EIQPKEN------SRMIKEEHNMADNNHENKQDIYKEGELMRGDKKPESHLNLVSAETFRHL-SKQEENAGG GGPAEFSRHKT------------------------------TGEHTG---------SKKAFNRISHVGSKSR VYEREKDETLR------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------RRS---------------- ------------------------------------------------------------------------ ---------------------INAGTGG-------------------------------------------- -----------------------------------------GTG---------------------------- --------MGTGSKMNKGPRTYYILK---------EED---------------------------------- DDIE----------------------RKAS---------------------------------------VL- ---------LPVLEDI--EK---------------------------------------------------- -------------------------------------VF--HDLVASGDVAATKNFLN--NHQD-------- ------------------------------------------------FNINCVNY-----------Q-KIS ALHVAV------------------------------------------------------------------ --KQQNE------EMVEFLLEQ------------------------------------KGI----------- -----------------------------DI-S-----------------DCALYAIK-------------- ---------EGSIKIV--------ELIFEK------------------------------------------ ------------IR---------------------------------------------------------- ------------EI----------------------SPGLEFAG---------------------------- ------T------------THSVDFSDDL------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------TPI--------------------------ILAAQL----G------------------------N YEMID--------------------------------FLIKR-G--HGIPPVHPP----------------- ------------------------------------------FC------KCDACKADLKKYDR-LKYSTMK ---------------------------------------------LNLYKAICN------------------ ------------------------------------------------------------------------ PMYIFHTRD----------------------------------------------------------DPF-- ------------------------------------------------------------------------ ---QRAFELTKELQDAAT------------------------------------------------------ -----------------------VFPQFKTSFE--ELWCSLRTFTVELIGCCRNAQE--------------- VEIILK-KS--------------------------------------------------------------- --PKS-VA-----------------------------------------EHVKFPRLQDAIDLK-Q-----K EFVSHPYTQ-----------AVLSDA--------------------------------------WT------ ----------------GELFEWKIRSPLMQSLAVFP--RIPMLPFMTI--LCMFLP---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------NHSLV--------RKWKTPVNKMISNVASYLIFLIILFLESN--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------LDKTK----------------------------------------------------- ------QKRGPPNSGLEIVIIIYVIGYIW---------LNIR-TC--FKQ---------------------- GLKRFF-S----------TMWHWYDTIM-------------------LLLFALTIIFWIASLVDITANNDV- -----------DLP-----------------RK-------------YWNSLDPELVAEGLF----AAAVIMA FFRLNLFLS----------------------------------------------LNYHLGP--LQVSIGKM TL-DIFRFIIIFFIIILAW--CAGLCRFYQPYDGMVQKDAV----------SG------------------- -------------------------------------------STTTQVSS-F------------------- --------------------------------------------VS-------------------------- ----------------------------------------------------FLM-----------T----- ---------------------LKTFFWAIFGMSP--IESAD---VI--------IENLPGDTPDT------- --------------TIINK--------------------HQFT--EAVGY----IAFALFQFLSVVVVLNML VACMANTFTKVIDNVTVEWVFGRSQIY------------------------LIFMAY--------------- ---SVLP-------PP--------------------FNLLPTASGIKD-------MCKWF---------RLL AR-------------------------------PTEGQRAKCNLAHCCYIESETEAYVNNEFPSLISELAQ- --------------------------RYIRLKVQE------------------------------------- ------------GEEQQ-TNQE-IEELRNELHEIK------------------------------------- ------------------------------------------------------------------------ -------------------------EI------------IKK--LY-------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------PIKR------------------SNI--------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------Y------------- >PhPain/1-978 ------------------------------------------------------------------------ --MS-------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------GKLPVECFEMT---------------- ---------------------------------------------SKDFCSTNP------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------AHVQ---- ------------------------------------------------ND---------------------- --------------------------------LLNA-WRK-----------------KDI-T-------NFL SVLSSN------------------------------------ECDPN------------------------- ------------------------------------------------F-------------LYEN------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------DNYM--------------------------------------------------------- RLLDS---------------------AVENGN-----VEFAEAIIK--------------------AG-AD- ---------VN--LIN-PVRS--------------------------------------------------- -----------------------------------KAPV--HFAAETGQLELLK-LLV-------------- --------------------------------------------SRGA-DINIRDS-----------S-GST ILHYVVKQ---------------------------------------------------------KW-P--- -PGEQK----FK-KCLAYLLE-----------------------------LDS-----LKV----------- -----------------------------NM-T-----NRKGL-------TAIHLAAM-------------- ---------QGSGEAV--------KMLLEK-GSH-LDIDSIKV---------GSARRTARQEIMHKFPHLEK DLPS--------PR----DIYD--IKMDGDKLFSLLHDNHEDRFCETFN-EEMKDKAQ-K------------ -NLLKYTDGKQTFL--------QYCCE---------KKFSKAVK---------------------------- ------TLL---------EYDVDVNYA--------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --PNNSTRPV--------------------------LIACRK----G------------------------D SETLR--------------------------------LL---------L----SA-------KPD------- ---L---------------------------SCNEDGENPLHIVVK----YTDNS-P--DHLDC-LQILLRR LN--------------------------------------KSNLDINAQD---------------------- ------------------------LKGNS------------------------------------------- --------------------------------------------------------------------PLHY AVK------------------YGGP---------ACVEELLKNGAYIGT-LNK------------------- -FKKPPLADMS------------------------------------------------------------- -----------------------------------------SSTLGNYLDSCITATD--------VLDRGNN YVIKFNYNF--------------------------------------------------------------- LVPKNCL------------------VHSELEDIKIPLTDDNETVNLLQESIPESQPLLYMSKDS-H----LR KLLVHPVLT-----------SFILLK--------------------------------------WQ------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------R------------------- ----------------VRIF-----------------YYVNLIFYVLFCFLLTVYI-------------LFG CV------------------------------------------------EH-------------------- -----------------TSE-------NVLILT-------------TVAINPEDFLG--------------- ------------------------------------------------------------------------ GGG-NGSNEGKDIFNESPG----------------------------------------------------- -------VDFLRVCLIIFLIALT-----L---------RELF-QI--VI----------------------- HPKKYV-L----------DPENWLEILL----------------------LIVLAFVLVKDCS--------- -------------------------------RE-------------FPKSTRLGLWCPQFS----ALAILLS WFELVLLAG----------------------------------------------KHPLQSL--HIEMFKTV SI-NFMKFLAWYVILIVAF--ALTFYTLF----------------------RDC-------------GADC- EENNP-------------------------------------------FVN-P------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------GLS----- ---------------------IFKSIVMLTGEFD--ASDIPFV----------------------------- ----------------------------------------TF---IGTSH----LIFIAFIFLIAIVLLNLL NGLAVTDTQTIRNDAYLCRCIALVKLI------------------------SYIENM-------------LL VESDPIP-------------CLNLFKC--CSKKK--KNNNFNLNCF-----------DYLAK---------- --RIVFFPKL-----------------------------------------------LKD-GIIYV------ --------------------------LPNQRYKIYF--EDPKSIKEED---------T-------------- -------ICYNRLTNYYLDPST-AKTAER---------------------------------ILSERVSSKG NPVAEMDT-----------------------LRNEINN----C----------------------------- ------------------------------------TERIFE--ME-------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------KKMES---------------------------------- ------------------------------------------------------------------LEQS-- -----------------TKQNEKLLI-----------------QI--------------------------- ------------------------------------------LAILSLNNAN-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------NDDK------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >PhPkd2/1-764 ------------------------------------------------------------------------ --MESGKNYQ-------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------IVPYGH------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----NLKLENET-----------------------I------------------------------------ ------------------------------------------VRSVFTK----------------------- ---------------------------------------------------------GKSKK---------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---NLFDPKKS------------------------------------------------------------- ------------------------------------------------------------------------ ----------------------------------------------------IEKN---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------ID-----EN---------------------------------- RSIDL----------------------------------------------------------------SN- ---------SETVEKP-ANKDVIV------------------------------------------------ ----------------------------------IKSPK--PRKTKKNKNSPNQKINK-------------- ----------------------------------------NKDKNKNDNDVDSDDEEDDEKLKPKNES-GAI FFYNKFKKAT------------------------------------------------------------KR -------------RLTKTRLKLK-----------------------------------SKL----------- ---------------------------HPEQ-------DFKGPYI-----YDFEVAVH-------------- ---------SQTANMFY-YKDITVQLFFNT-------------------------------------PYL-- ------------PD--------------------------------FIN---------------------MS VQIDAENITTGKTL-----SESHTLSDFW-------SVKTTMIN---------------------------- ------LFY--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --ESFFFPPI--------------------D----------------------------------------Y TQYMD---------------------------DDRE-MFYEN-EI-LGVPRMRQV----------------- ----------------RVED----------------NSCLIHPSMQRF-----------------FRHCFSY YSI-------------------------------------------------YT------------------ --------------------------EET------------------------------------------- -------------------------------------------------------------------EPIKT GMEGTI----------------------------SETAWVYTEAEELNT-SSYWGQISIYGGGGYYVDLGR- -TKESAIRII-------------------------------------------------------------- -----------------------------NELR------------------------------DNEWISRAT RAVFIDFNIYN----------ANVNYF--------------------------------------------- -------------------CIC-------------------------------------------------K IVIEFPPMGGMIPNADFHPLKLIKYL--------------------------------------WF------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------WD------------------- -------------------------------------FVVLGLEFVRFVFLIYFIYILV------------- ------------------------------------------------------------------------ ---------------------------N-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------RI--LT----------------------- QKLQFF-F----------SFWNIFEFFLIA---------------LSIIHYILALYLYVLVSKTIKSLAERF T---------------------------------------------LYTEFDYIKQLHLLYGTNFAFIVLFS WLKLIKYLNYNTIMVE------------------------------------------------FQDTIARS VG-SILAFFPMFLSMFTGF--SLLGFLLF---------------------------G--------------- -------------------------------------------SQIRDYRT--------------------- -------------W---------------------------------------------------------- ----------------------------------------------------------------WSS----- ---------------------SLSLLQTIIGEFE--YQEIQNA-------------------------E--- ---------------------------------------------PVFGP----IFYIVYIFFMVFLALNVF IAIITDAYTHVKTKV--------------------------------------------------------- --TTRVP-----------------------------------------------KHGHYLKRGFMNVLTPCG WDKK--FAKFNV--------KEKAGFT---------DSEIKIFFSK---------------YDINMNNILSE G----------------------------------------------------------------------- -----------------IKDKI-INDLEFKIADY-------------------------------------- ------------------------------------------------------------------------ ------------------------------------EESAEE------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------FE-- ---------------------------------------------------------------IKLLKRRMN E------------VYDKIEDIEANLQ-----------------PILD------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------KVDALLHKY---------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >PhPyr/1-777 ------------------------------------------------------------------------ --MN-------------------------------------------------------------------- ------------------------------------------------------------------------ --GKR------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ DVEEQEVI--D---DDDDD----------------------------------------------------- --NVS--NETEEIGAA-------------------------------------------------------- ---------------------------------------------GNDTDQ--------------------- ---------------------------------------------------PQS------------------ ----------LQIQ---------------------------------------------------------- ------------------------------------------------------------------------ -EIWHKKEI----------------------------------LESL------------------------- ---------------------NILP--------------------------------GSQ-E--------LQ SLIAA-----------------------------------------RDYKRVLS-H-PNSSL---------- ---------------------------------------------TGLLLASFSGNAELLQAILRR-SMVV- ---NVRD-R--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------EGR--------------------------------------------------------- TPLHL---------------------ACCAG-----SAECVKILLD--------------------HK-AM- ---------PNVWNK---EGV--------------------------------------------------- -----------------------------------ITPL--HCAASVGNIQCLKLLLD-------------- --------------------------------------------AGA--ILDAGLTTT------G--F-GKT PLYYAVLSNS-------------------------------------------------------------- ------I------NCVEELLK-----------------------------RNA------SI----------- -----------------------------NT-S-----QVYTE-------TPLHVAAA-------------- ---------MGFASCL--------KLLLDH-GAD-FRVKF-------------------------------- ------------------------------------------------------------------------ ------GTAKSTPL--------HLAAE---------DGNAECAK---------------------------- ------LLI---------EAGADLMSRT-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---NRIQTPL--------------------------HLAALA----Q------------------------S VQTLE--------------------------------LLLMH-R--ADPN-AEDI-------DKR------- --------------------------------------TPLHCAIVK----------SSRSCDS-VQLLLQY GAK------------------------------------------VNAPDV-F------------------- --------------------------GYT------------------------------------------- --------------------------------------------------------------------PVHI AA------------------LNEFP---------NCLKLLLDHGGDVTK-RTN------------------- -GNVSALSFI-------------------------------------------------------------- -------------------------------AR--RTP-EILKYLERKLDQGIRLHDH--------EIGDVD CEIKLDFRV--------------------------------------------------------------- LVPS--------------------------------------------LSSG-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------I F-------------------------------------------------LDSC------------------ ----------------------------------------------------ADF----------------- ------------------------------------------------------------------------ -------KK-----CTIPM----------------------------------SFR---------------- --------------YVSYVLLVCNFSILG---------KELF-QI--AH----------------------- IRRGYI-Y----------QWENWLQW-L----------------------IILAVFVTL------------- ------------VP--------------------PNWLSLK--FV-TWQH--------HIA----VFGIFFN WIELMVLIG----------------------------------------------RFPMFGL--YVQMFTKG AV-NFGKFLLAYFCLLAAF--SFSFRMLF----------------------PK------------------- --YPS-------------------------------------------FNS-T------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------INS----- ---------------------IVKIVAMMTGELE--FEDIFFN----------------------------- -------S---EDPLY-------------------------Y---PGTSH----IFFLFFTLIVTVVLTNLL VGLSVSDIQGLQTSAGLDRLTRQVELV------------------------AYMESMLFSRLLNWI------ ------P------------------------------------KKIL----------RVCHR---------- --SA-LLL----------------------------SSPRQFT--------------------LII------ --------------------------KPNDPREKR------------------------------------- -----------------IPKEL-VKEA--------YKC-------------------------VSER-RGIQ S-----------------------------------------------------------------PVLKTE FITN---------------------YF----------ER--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------NR--------------------FPHSR---------- ---------------------------------------------------------------HEIYVSK-- ------------------------RK-----------------K---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------RNK-------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >PhTRPA1/1-1175 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------M------------------------------- -------------------------------------------------------------VP--------- ------------------------------------------------------------------LRDNI- ----RNFLP-----NFIC----------------------------------RRDTVTP-K---VTPP---- TIVVR--------------------------------NW-----------------KKVLLG---------- ------FPFSQKL---------------------SPDELIEAAESGNLE-DFGRL----------------- -------------------------FMADPNRLE-----------IR-DSKGRAA----------------- --------AHQAAA---------RNKVNILQFIHSHGG---------------------------------- ----DLNIRDYA---------------------------------------------------GNTPLHVAI ------------------------------------------LNDSYN------------------------ -----VMDFLLQCG----VNTSILNEKNQAP-IHLI-TEL-----------------NKV-K--------AL EVLSKHRSKI--------------------------------DIQQGGEHG--------------------- --------------------------------------------RTALHLTAIYDYEECARILITE--FGA- ---CPRKP---------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------CN----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------NGY--------------------------------------------------------- YPIHE---------------------AAKNA-----SSKTMEVFLQ--------------------WG-ESR GC--SREEMMSFYDS---EGNVPL---------HSAVHGGDIRAVE-------------------------- -----------LCLKSGAKISTQQHDL--------STPV--HLACAQGAIEIVRLMFK-------------- ------MQPHEKEICLTSCDVQK-----------------------------------------------MT PLHCAAMFDH-------------------------------------------------------------- ------P------EIVEYLIS-----------------------------EGA------EI----------- -----------------------------NP-L-----DKENR-------SPLLLAAS-------------- ---------RAGWRTV--------LTLIRL-KAN-ILLKDSSYRNILSLVVMNGG--RLEDFAQ-------- ---------------------------------EVLKVQSKKDLLLLLN----------------------- ----EKDISGCSPL--------HYASR---------EGHIKSLE---------------------------- ------SLI---------KLGACINLKNNNNESP-------------------------------------- ------------------------------------------------------------------------ --------------------------------LHFAARYGRYNTVKQLLDS-------------EKGTFIIN ECDGEGLTPL--------------------------HIASKN----G------------------------H SRVVQ--------------------------------LLLNR-G--ALL--HRDH-------YGR------- --------------------------------------NPLHLAA------------MNGYTQT-MELLHSV HSH-----------------------------------------LLDQVDK-D------------------- --------------------------GNT------------------------------------------- --------------------------------------------------------------------TLHL ASM------------------ENKP---------NAISLLLSLNCKLLY--NY------------------- -LEMSAIDYA---IHYK---------------------------------------FQEAALAMVTHPTRSC --------EVMALKSDKHP------CVTLALIA--SM----PKVFEAVQNGCITKANC--------KKDSKS FYVKYHFSC------------LQCPTI-YAQVDEKTGETLTITNPIPLPAL--------------------- ---------------------------------------------------------NAMVSHG-R-----V ELLAHPLSQ-----------KYLQMK--------------------------------------WN------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------S------------------- ---------------YGKYF-----------------HLINLLFYTIFLTVVTTFT-------------AHL MH---------------------------------------------SNITT-------------------- ---------------TCEES-------N-------------------------------------------- ------------------------------------------------------------------------ -QT-VVLSEISLRLES--SSNYT------------------------------------------------- -----------IIYTTAVAIAVYVSVQLF---------RETI-QM--YQ----------------------- QKWNYC-M----------DPSNFISLGL----------------------YISSITMIVPIFM--------- ------------------------------------------DKCTDLQF--------SSA----AITVFLS WFNLLLYLQ----------------------------------------------RFDQVGI--YIVMFLEI LQ-TLIKVLLVFSILIIAF--GLAFYILL----------------------SG------------------- GSHLS-------------------------------------------FST-V------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------PMS----- ---------------------LMRTFAMMLGEID--FLGTYVQPFFRKPE-------DSDDVS--------- ------EDK-IK-T-L------------------------PY---PFPAF----FILGIFMVLMPILLMNLL IGLAVGDIESVRRNAQLKRLAMQVVLH------------------------TELERKL-------------- ------P------------------------------------KCLL----------DRVDK---------- --ME-----------------------------------------------------------LIE------ --------------------------YPNEKKCK-------------------------------------- ------------------LGFL-DTLLGK------W-FFNP------------------------------- ----------------------------------------------------FSDDVGWE------------ -------------------------------------MVVDN--TED------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------YLTSE----------------------------------- ------------------------------------------------------------------MAKQ-- ---------------------KKKLK-----------------EI--------------------SSC---- ---------------------------------------------LETQQLF-------------------- ------------------------------------------------------------------------ ------------LRLIIQK----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------MEIK------------------------------------------------ --------------------------------------------------------------------TEAD DVD--------------------------------------------------------------------- ---------------------------EGISP--NALKNLLNR----------------------SS----S ---------------S-YTSPYAR------------------------------------------------ -------------KKLRS--SLSITKS--------------------------------------------- ----------------------------------------------------SNY----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >PhTRPM/1-1760 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------MNFEK------------------ ------------------------------------------------------------------------ --KCCCGLS-LTHHRGT-GAKIQPPY---------------------------------------------- --ESQWISSRHT---------------------------------------------------ISVPTDAYG TLEFQGGPHP--------------------------------SKAQYVR----------------------- ------------------LSYDTRPELILQL-FTRE--------WSLETPKLLITVQGGK-A-----NFDLQ PKLKK---------------------------------ILRKGLLKAAKTT--------------------- -----------------------------------GAWIFTGGTNT-V---------------TRQVGDAL- ---LLERSQ--------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------RSS---------------- ------------------------------------------------------------------------ ----------------------RIVTIGI------------------------------------------- ----------------------------------------APWG---------------------------- --------IVENNYEL-------------IG-----RN---------------------------------- RDVPY----HSIS--------------SPR------------------------------------YG-AE- ---------IILRRKL--EK-------------YISIQKLHPCTHC-------------------------- -----------------------------------STPV--VCLVIEGGTNTIRAVLE--YVTDDP------ -----------------------------------------------PVPVVVCDG-----------S-GRA ADLLAFVHKYASES-----GEQTVLENMKDYLIGTIQRTFEVGSEQSEC-------------LYSELLQ--- --CTQCK--------------------------------------------------TQEL----------- -----------------------------DQ-T-I--------------LTALFKSQH-------------- ---------LSPSE----------QLSL-------------------------------------------- ------------------------------------------------------------------------ ------------AL------------------------TWNRVD---------------------------- ------IA------------RSEIFVYGQEWP---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------PGAL----------------------DEAMMQALEH----D------------------------R IDFVK--------------------------------LLLEN-G--VSMKKFLTI--------PRL------ --------------------------------------EELYNT-------------KQGPTNT-LGYILRD --------------------VRP-HIPRGYVYTLHDIGLVINKLMGGAYRSYYT-----------RRKFRLI YAKVMKKSP------------HVHRNSAS----------------------FIRYYGNQ--------N---- -LTLSLL-----------------------------------AEALPATSDTPL----------FD-YPFNE LMIWAV--------------LTKRQ---------QMALLMWQHGEEALA----------------------- -KSLISCKLYKAMAHEAAED---------------------------------------------------- ----------------------DLETEVYEELR--NYGKEFENIALELLDFCYRQDDD-------------Q AQQLLTCELQ-------------------------------------------------------------- -------------------------------------------------NWSGQTCLSLAVAAN-H-----R ALLAHPCSQ-----------IILADL--------------------------------------WM------ ----------------GGLR--TRKNTNLKVI------LGLLCPPYIC--QLEFK----------------- -SKEELQSMPQTEEEHLT------------------------GLEEENESVDG------------------- -EMKFNQTH-----------------------------RNTDPETEALFAQDFG-------VKD-------- TIIQENGKV------------------------ITEDDTEIGNSFHHIP-------------LDFHDVKAAR PLRLK-----------KKFY--------EFYTAPITKFWAHSLAYMVFLMFFSYVV-------------LVK MEN--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------MPSWQEYYIITYICTLGF---------EKIR-EI--VSS----EPV-----------AISH KFAVWT-W----------NMWNPCDSAA-------------------IIFFLIGLALRLK------------ -------------------------------------------------PSS-MAIGRVIF----CVNIVYW YLRILNILG----------------------------------------------VNKYLGP--LVTMMGKM VK-NMIYFVVLLLVVLMSF--GVCRQSILNPN-------------------RE------------------- -------------------------------------------ASWTSVKE--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------V----- ---------------------FYQPYFMLYGEVF--AGDID---------------PPCGE----------- -------HPTDSP-CPTGR---------------------------WVTP----VVMSIYLLVANILLINLL IAVFNNIFIEVNAVSHQVWMFQRFTVV------------------------MEYEQK--------------- ---PGIP-------PP--------------------LIIISHLFLLFK----------FVRR---------- --KL----------------KGIE---------ETYDNALKLFLDN------DDLERLYDFEEECVEGYFR- -------------------------EKDLKLLQSS------------------------------------- ------------DERIKTTTEK-VENMYQKVEDINQKENAQTT----------------SIQSVEFRLRKVE DVAEQILNHLDVVHRFMATHTR----------------DTAF------PDFPEVNIVADRTRTASERSED-- ------------------------VKV------------MAA--PDSEFAERLLSLTEVRP------T---- -----DR-------LCLSA---------------ERIY------VDPKRHEIP-------LENS-------- -----------------------------------------------------------------NNSNQKG E----------------------------------DEVEYPG----------------DEK--------S-- ----FIDRRLSESSAAEKHED------------------V---------SVCRE-----------STKGSHV ---------------EVN-RPQETQEI--ERPL----SSADGSVGL------------------------RK R----------------------------------------RGSSTEEKSDRGS------------------ ----------------------------------------------------VLP----------------- ------LCHLSTRRQLSQT-HSEPD--VDFLGL--------------------------------------- ---------GSSVP-RAV--------TVERSV-T-WA-----------------EPRIT------------- ------------------------------------------------------------------------ ----------------------------------VIPPTA-----STA-----------RSMLLA------- -------------MHSEYTSITDE---------------------------------------------LET VC-GLLSPPRTP------------SLLTPTTKKDTVHPKRTRHTSEMSNP------EMAIYIEK----EHLR DAEESDYQLMQDLIDKRFYIGENS-------------EIDERFDNN-----------------------AFF LTVTDE----VNDYRSP-FQSRY---LRRS-----SAIEIKDQ----------PQ---------SNDGSQSN SQLQINNSVSIDSSGP-CQVEVCLSSRGNSVEEPQVIVKEHPASDETNANEVFESDDVTRAKYLNDKCDNKG SVETSDETKQSSHFQSGETDSKNGGRQQQQQQQQQQQQQQLVQEPQEYQIKKIHLHRNNSETEGSTSTKGTT QQSSEISNETHFLYREHIKPTTGRKLSRQESQGKVGRTNTLAMDFEMGHNSKKISSQP-------------- ----------------------------------------------SLP-PQKEEESSSPP----------- ------------------------------------------------------------------------ -------------------------------------------ENEERG-SRDSLMMPSETMC--------- >PhTRPML/1-548 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------MTTE---------------------TNN-E---------- --------------------------------------LDDDRILEESL----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------RE--------- ----------------------------------------NAFS---------------------------- -------G---------------------------------------------------------------- ------------------------------------------------------------------------ ----------------------------------------------F------------------------- -----------------------------------DERLI--------EEESLKRKLK-------------- ---FF--------------------------------------------YMNPIEKWN-------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------NFMFSNKISFCHLFLSGWDAT-------------------------------------- ------------RE---------------------------------------------------------- -VIAYPPQSGDLAI-------------------YKISDFYTVID---------------------------- ------YAVINYANLDD-AIGSYKY----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ P-NNSSMGHIQMCL-KLKNG----------------LNESDNCKHYN---------------CYNLN----D FQIRVECLTII------VT------KENSKNFSIKN-YFDEN-K--IKL----EF----------------- --------------------------------------SSLIDAT--------------------LSFEIKT V-----------------------------------------HSNLISLNC--------------------- ------------------------------------------------------------------------ -------------------------------------------------------------------FSFNI SIK-----------------FDNKH----------------------------------------------- NSGQMKYDLT-------------------------------------------------------------- -------------------------------------------LNIKGLN-CDKKY---------FNPPYSI IISFLNFSVI-------------------------------------------------------------- -------------------IICCL-----------------------------------------SIILCVR SLLRTQYLKKKTI-------YHFKKYYSRNVSWEGRMEFFNP----------------------WY------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------VIMIFGDVLILI---S-----LVFRYKI--------------------------- EEDEFS-G----------DELNMCSLIL-------------------------------------------- -----------------------------------------------------------------GCGNFLV WFSLLRYLC----------------------------------------------FFKTYNA--IILTLKMA AP-NIFRFMVCVLLIYSSF--TFSGWLILGPYH--------------------------------------- --------------------------MK--------------------FRT-L------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------SGT----- ---------------------SECLFALINGDDV--FATFNTLQPTD------------------------- ---------------------------------------SKTI--WYFCR----IYLYVFISLFIYVVLSLF LSIVEGAYEIIK---------------------------------------QSGKDGF-------------- ------P---------------------------------------------KSDIKTFIET---------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------SSNNS-LQSLAS------------------------------------------- ------------------------------------------------------------------------ -------------------------SS-----------------YPDCT----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------LICN------------------------ ------------A---------------------------------DNLK---------------------- ------------------------------------------------------------------------ ------------LKNITAK----------------------------------------------------- ------------------------------------------------------------------------ ------------ICCCQSL----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------LKNPRT- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >PhWtrw/1-1022 ------------------------------------------------------------------------ --ME-------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------LNFTKDY------------------------------- ------------------------------------------------------------DQKQ-------- -------------------------------------------PFDR------------------------- ------------------------------------------------------------------------ --SISFGRELSV------------------------------------------------------------ ------------------------------------------------------ID-T-------------- ------------------------------------------------SQKCRT------------------ -----------PS-------------------FLERL---KSFGEDRAS---------------------ML QRSKHIDLED------------------------------------------------------SSSSALDD IIFL----------------------------------------DSFEEI---------------------- -----HQKGDANVL----VSRDVVRQNILDM-MKSG-S-------------------GNV-K--------LL TDIET------------------------------------GNTSVNNIEEHFA-N--SSQF---------- ------------------------------------------EKNVGFLWSVFHRRRDLLDYFLQF-NVDV- ---NFSEPQ--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------LGF--------------------------------------------------------- TPLHL---------------------SSFSG-----CNNCTALLIS--------------------KG-AD- ---------VNT--L---TNK--------------------------------------------------- -----------------------------------YTPL--HCAAFGNAASTAKLLLK-------------- --------------------------------------------AGA--KI---VSEK--VCN-------ET PIHSAVRSKA-------------------------------------------------------------- ------V------DCLQLFIT-----------------------------ENM------DL----------- -----------------------------SN-M-----GGCGY-------SPLHLAAD-------------- ---------LGHLQCL--------QILLNSNKCD-INLQT-------------------------------- ------------------------------------------------------------------------ ------LERKCSAL--------HLAAE---------NGYYECLK---------------------------- ------TLL---------EYGADSNAVN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---YRQQTPL--------------------------HAAAKV----C------------------------S -ESVE--------------------------------LLLKY-G--ADPN-SPDA-------DNR------- --------------------------------------TPMHAAVCKC--------ESEHSLEI-LDYLTMW KGD------------------------------------------VNRRDK-Y------------------- --------------------------GYT------------------------------------------- --------------------------------------------------------------------PLHI AA------------------LNELT---------ECVECLILSGSDVTA-RTR------------------- -GGTSALSII-------------------------------------------------------------- -------------------------------SR--KTP-AALGAVNQKLDESITTN-DP-------DA-SKE IVLMFNFRY--------------------------------------------------------------- LLKN--------------------------------------------CKRGEVSFLQTLVDEG-Q-----K EFLSHPLCE-----------AFLHLK--------------------------------------WQ------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------K------------------- ----------------IRKY-----------------YITRLIFCLLFVILLSLYV-------------LTA L-------------------------------------------------AYQCY----------------- -N-------------DSVSD-------V---FP---DVEA------RILIVDPELC---------------- ------------------------------------------------------------------------ ----TKKSYFGELLRRNPI----------------------------------IME---------------- --------------MEWFFLVFITVLEIF---------RKIY-GFRGYK----------------------- SFRHYI-S----------QKGNIVEW-F----------------------VVLSVFLISF------------ ----------VYTG-----------------R-----------TY-IWQN--------HVG----ALAVLCG WANLMIMIG----------------------------------------------NLPIFGS--YVAMYTKV QK-EFTKLFLAYICLLIGF--TVCFCVIF----------------------PK------------------- --AKQ-------------------------------------------FSN-P------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------FVA----- ---------------------VIKILVMMTGELE--FDSLLENITQE------------------------- -------ES--HSATL-------------------------L---EISAL----TTFVFFLLFVTIILMNLL IGIAVHDIQGLQKTAVLSKLVGQTKLI------------------------THIESALFNGCL--------- ------P------------------------------------NCFL----------KLLQI---------- --TA-LIS----------------------------PSSYRVV--------------------VSV------ --------------------------KPLNPRETR------------------------------------- -----------------LPQDV-MRSG--------LKV-------------------------AKQK-R--- ----------------------------------AKGP-------------TPSARSSMR--YPTMKKRKTM MMMN-----------------------------------------EE------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------VIA--------------------DMRNA---------- ---------------------------------------------------------------LSKLMDE-- ------------------------VG-----------------TI--------------------------- ------------------------------------------KRLIMAGERNDILFPLL--LTDMLGKVDIE CTVENGGPSG-----------------QAGAL---------------------------------------- ---------RYAISKTLYT----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------LVDENVRAK------------------------------------------- ----------------------------------------------------------MMLAGLTQRDIRRR ERK--------------------------------------------------------------------- ---------------------------KP------------------------------------------- ------------------------------------------------------------------------ -----------------GRDGARRRYT--------------------------------------------- ----------------------------------------------------WLKR---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >RAT_TRPA1/1-1125 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --MKR------------------------------------------------------------------- -----------------------------------SLRRVL------------------------------- -------------------------------------------------------------RP--------- -----------------------------------------------------------------EERKEVQ GVVYR-----------------------------------------GVGKD--------------------- ----------------------MDC----------------------------------------------- ------SKESFKV---------------------------------DIEGDMCRLE-A-------------- -------------------------FIKNRRKLS-----------KY-EDENLCL----------------- --------LHHAAA---------EGQVELMQLIINGSSC--------------------------------- ---EALNVMDDY---------------------------------------------------GNTPLHWAA ------------------------------------------EKNQVE------------------------ -----SVKFLLSQG----ANPNLRNRNMMAP-LHIA-VQG-----------------MYN-E--------VI KVLTEHKA-T--------------------------------NINLEGENG--------------------- --------------------------------------------NTALMSTCAKDNSEALQILLEK-GAKL- ---C--KS---------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------NK----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------WGD--------------------------------------------------------- YPVHQ---------------------AAFSG-----AKRCMELILA--------------------YG-EKT GY--SREAHINFVNH---KKASPL---------HLAVQSGDLDMIK-------------------------- -----------MCLDSGAHIDMMENAK--------CMAL--HFAATQGATDIVKLMIS-------------- ------SYTGSSDI-VNAVDGNQ-----------------------------------------------ET LLHRASLFDH-------------------------------------------------------------- ------H------DLADYLIS-----------------------------VGA------DI----------- -----------------------------NS-T-----DSEGR-------SPLILATA-------------- ---------SASWNIV--------NLLLSK-GAK-VDIKDHLGRNFLHLTVQQPY--GLRNLRP-------- ---------------------------------EFLQMQ---HIKELVM----------------------- ----DEDNDGCTPL--------HYACR---------QGAPVSVN---------------------------- ------NLL---------RFNVSVHSKSKDKKSP-------------------------------------- ------------------------------------------------------------------------ --------------------------------LHFAASYGRINTCQRLLQD-------------ISDTRLLN EGDLHGMTPL--------------------------HLAAKN----G------------------------H DKVVQ--------------------------------LLLKK-G--ALF--LSDH-------NGW------- --------------------------------------TALHHAS------------MGGYTQT-MKVILDT NLK-----------------------------------------CTDRLDE-E------------------- --------------------------GNT------------------------------------------- --------------------------------------------------------------------ALHF AAR------------------EGHA---------KAVAMLLSYNADILL--NK------------------- -KQASFLHIA---LHNK---------------------------------------RKEVVLTTIRSKRWDE C------LQVFTHDSPSNR------CPIMEMVE--YL----PECMKVLLDFCMIPSTE--------DKSCQD YHIEYNFKY------------LQCP--------------LSMTKKVT-PTQDVIY----------------- ---------------------------------------------------EPLTILNVMVQHN-R-----I ELLNHPVCR-----------EYLLMK--------------------------------------WC------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------A------------------- ---------------YGFRA-----------------HMMNLGSYCLGLIPMTLLV-------------VKI Q----------------------------------------------------------------------- ---------------PGMAF-------N-------------------------------------------- ------------------------------------------------------------------------ -ST-GIINETISTHEER-INTLNSF----------------------------------------------- -----------PLKICMILVFLSSIFGYC---------KEVV-QI--FQ----------------------- QKRNYF-L----------DYNNALEWVI----------------------YTTSMIFVLPLFL--------- ------------------------------------------DIPAYMQW--------QCG----AIAIFFY WMNFLLYLQ----------------------------------------------RFENCGI--FIVMLEVI FK-TLLRSTGVFIFLLLAF--GLSFYVLL----------------------NF------------------- --QDA-------------------------------------------FST-P------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------LLS----- ---------------------LIQTFSMMLGDIN--YRDAFLEPLFR------------------------- -------NE------L------------------------AY---PVLTF----GQLIAFTMFVPIVLMNLL IGLAVGDIAEVQKHASLKRIAMQVELH------------------------TNLEKKL-------------- ------P------------------------------------FWYL----------RKVDQ---------- --RS-----------------------------------------------------------TIV------ --------------------------YPNRPRHG-------------------------------------- ----------------RMLRFF-HYFLSM------Q------------------------------------ ------------------------------------------------------------------------ ----------------------------------ETRQEAPN--IDT------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------CLEME----------------------------------- ------------------------------------------------------------------ILKQ-- ---------------------KYRLK-----------------DL--------------------TSL---- ---------------------------------------------LEKQHEL-------------------- ------------------------------------------------------------------------ ------------IKLIIQK----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------MEII------------------------------------------------ --------------------------------------------------------------------SETE DED--------------------------------------------------------------------- ---------------------------NHCSF--QDRFKKERL----------------------EQ-MH-S ---------------K-WNFVLNA------------------------------------------------ -------------VKTKTHCSISHPDI--------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >RNorTRPM8/1-1104 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------MSFEGARL------------------ ---------------------------------SMRSRRNGTLGSTRTLYSS-------------------- ----------------------------------------------------------------VSRSTD-- -----------------------------------------------------------------------V SYS--------------------------------------------------------------------- --ESDLVN---------------------------------------------------------------- ----------------------------------------------FIQANFKKRE----------CVF--- ---------------------------------------------FTRDSK---A----------------M ESICKCGYA-QSQH-----IE---GTQINQ------------------------------------------ --NEKWNYKKHT---------------------------------------------------KEFPTDAFG DIQFETLGKK----------------------------------GKYLR----------------------- ------------------LSCDTDSETLYEL-LTQH--------WHLKTPNLVISVTGGA-K-----NFALK PRMRK---------------------------------IFSR-LIYIAQSK--------------------- -----------------------------------GAWILTGGTHYGL---------------MKYIGEVV- ---RDNTISRN------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------SEE---------------- ------------------------------------------------------------------------ ----------------------NIVAIGI------------------------------------------- ----------------------------------------AAWG---------------------------- --------MVSNRDTL-------------IRNCDDEGH---------------------------------- FSAQY-----IMDD-------------FMRDPLYILDNNHTHLLLVDNG-------------CHGHPT-VE- ---------AKLRNQL--EK-------------YISERTSQDSNYG-------------------------- ----------------------------------GKIPI--VCFAQGGGRETLKAINT--SVKSK------- ------------------------------------------------IPCVVVEG-----------S-GQI ADVIASLVEVE-DVLTS-SM-------VKEKLVRFLPRTVSRLPEEEIE-------------SWIKWLK--- -EILESP------HLLTVIKME---------------------------EAGD-----EVV----------- -----------------------------SS-A-I--------------SYALYKAFS-------------- ---------TNEQD----KDNWNGQLKL-------------------------------------------- ------------------------------------------------------------------------ ------------LL------------------------EWNQLD---------------------------- ------LA------------SDEIFTNDRRWE---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------SADL----------------------QEVMFTALIK----D------------------------R PKFVR--------------------------------LFLEN-G--LNLQKFLTN--------EVL------ --------------------------------------TELFST---------------HFSTL-VYRNLQ- ---------------IAKN----SYNDALLTFVWKLVANFRRSFWKED------------------RSSRED ------------------------------------------------------------------------ ----------------------------------------LDVE-LHDASL------TTRH-------PLQA LFIWAI--------------LQNKK---------ELSKVIWEQTKGCTL----------------------- -AALGASKLLKTLAKVKND----------------------------------------------------- -------------------------INAAGESE--ELANEYETRAVELFTECYSSDED-------------L AEQLLVYSCE-------------------------------------------------------------- -------------------------------------------------AWGGSNCLELAVEAT-D-----Q HFIAQPGVQ-----------NFLSKQ--------------------------------------WY------ ----------------GEI---SRDTKNWKII------LCLFIIPLVGCGLVSFR----------------- --KKPID----------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------------------------K HKK-------------LLWYY------VAFFTSPFVVFSWNVVFYIAFLLLFAYVL-------------LMD FHS--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------VPHTPELILYALVFVLFC---------DEVR-QW--YMN---------------------- -GVNYF-T----------DLWNVMDTLG-------------------LFYFIAGIVFRLHSS---------- -------------------------------------------------NKSSLYSGRVIF----CLDYIIF TLRLIHIFT----------------------------------------------VSRNLGP--KIIMLQRM LI-DVFFFLFLFAVWMVAF--GVARQGILRQNE------------------QR------------------- -------------------------------------------WRW-IFRS--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------V----- ---------------------IYEPYLAMFGQVP--SD-VD---ST-TYDF-----SHCTFSG--------- -------NES-KPLCVELD---------------EYNLPR-FP--EWITI----PLVCIYMLSTNILLVNLL VAMFGYTVGIVQENNDQVWKFQRYFLV------------------------QEYCNR--------------- ---LNIP-------FP--------------------FVVFAYFYMVVK----------KCFK-------CCC KEKN---------------------------------TESSACCFR------NEDNETLAWEGVMKENYLV- ------------------------------------------------------------------------ ---------------------K-INT----------------K----------------ANDNAEE------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------MRH----------------------R-------F--- ------------------------------------------------------------------------ ------------------------------------------------------------------------ RQLDTK-----------------------------------LND---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------LKGLL---------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------KEIANKIK--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ >RnorTRPM1/1-1628 ------------------------------------------------------------------------ --MG-------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------SMRKMSSSFKRGSIK---------------------- ------------------------------------------------------------SSTSGSQK---- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----GQKA---------------------------------------------------------------- ----------------------------------------------WIEKTFCKRE----------CIF--- ---------------------------------------------VIPSTK-DPN----------------- --RCCCGQL-TNQHIPP-LPSVTPSSTAEDT-------------------------------------KQGD AQSGKWSVSKHT---------------------------------------------------QSYPTDSYG ILEFQGGGYS--------------------------------NKAMYIR----------------------- ------------------VSYDTKPDSLLHL-MVKD--------WQLELPKLLISVHGGL-Q-----SFEMQ PKLKQ---------------------------------VFGKGLIKAAMTT--------------------- -----------------------------------GAWIFTGGVSTGV---------------VSHVGDAL- ---KDHSSK--------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------SRG---------------- ------------------------------------------------------------------------ ----------------------RLCAIGI------------------------------------------- ----------------------------------------APWG---------------------------- --------MVENKEDL-------------VG-----KD---------------------------------- VTRVY----QTMS--------------NPLSKLSVLNNSHTHFILADNG-------------TLGKYG-AE- ---------VKLRRQL--EK-------------HISLQKINTRLGQ-------------------------- -----------------------------------GVPV--VGLVVEGGPNVVSIVLE--YLREDP------ -----------------------------------------------PVPVVVCDG-----------S-GRA SDILSFAHKYCDEG-------GVINESLRDQLLVTIQKTFNYSKSQSHQ-------------LFAIIME--- --CMKKK------ELVTVFRMG---------------------------SEGQ-----QDV----------- -----------------------------EM-A-I--------------LTALLKGTN-------------- ---------VSAPD----------QLSL-------------------------------------------- ------------------------------------------------------------------------ ------------AL------------------------AWNRVD---------------------------- ------IA------------RSQIFVFGPHWPPLGSLAP--------------------------------- ------------------------------------------------------PVDTKVAEK--------- ------------EK-----------------KPPTATTKGRGKGKGKKKGKVKEEVEEETDPRKIEL----- ---LNWVNAL----------------------EQAMLDALVL----D------------------------R VDFVK--------------------------------LLIEN-G--VNMQHFLTI--------PRL------ --------------------------------------EELYNT-------------RLGPPNT-LHLLVRD --------------------VKKSNLPPDYHISLIDIGLVLEYLMGGAYRCNYT-----------RKSFRTL YNNLFGPKR--------------------------------------------------------------- PKALKLLG---MED-------DEPPAKG-------------KKKKKKKKEEEIDIDVDDPAVSRFQ-YPFHE LMVWAV--------------LMKRQ---------KMAVFLWQRGEECMA----------------------- -KALVACKLYKAMAHESSES---------------------------------------------------- ----------------------ELVDDISQDLD--NNSKDFGQLAVELLDQSYKHDEQ-------------V AMKLLTYELK-------------------------------------------------------------- -------------------------------------------------NWSNSTCLKLAVAAK-H-----R DFIAHTCSQ-----------MLLTDM--------------------------------------WM------ ----------------GRLR--MRKNPGLKVI------MGILIPPTIL--FLEFR----------------- -SYDDFSYQT----------------------------------SKENED---------------------- -----GKEK-----------------------------EEENVDANADAG---------SRKGD-------- ---------------------------------------------------------------EENEHKKQR SIPIG-----------TKIC--------EFYNAPIVKFWFYTISYLGYLLLFNYVI-------------LVR MDG--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------WPSPQEWIVISYIVSLAL---------EKIR-EI--LMS----EPG-----------KLSQ KIKVWL-Q----------EYWNITDLVA-------------------ISMFMVGAILRLQ------------ -------------------------------------------------NQPYMGYGRVIY----CVDIILW YIRVLDIFG----------------------------------------------VNKYLGP--YVMMIGKM MI-DMLYFVVIMLVVLMSF--GVARQAILHPE-------------------EK------------------- -------------------------------------------PSWKLARN--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------I----- ---------------------FYMPYWMIYGEVF--ADQIDRKTRIHIYAMEI--NPPCGENLYDEE----- ----GK---RLPP-CIPGA---------------------------WLTP----ALMACYLLVANILLVNLL IAVFNNTFFEVKSISNQVWKFQRYQLI------------------------MTFHDR--------------- ---PVLP-------PP--------------------MIILSHIYIIVM----------RLSG-------RCR K-KR----------------EGDQ---------EERDRGLKLFLSD------EELKKLHEFEEQCVQEHFR- -------------------------EKEDEQQSSS------------------------------------- ------------DERIRVTSER-VENMSMRLEEINERENFMKA----------------SLQTVDLRLSQLE ELSGRMVGALENL-----------------------------------AGIDRSDLIQARSRASSEC-E--- --------------------------------------------------ATY---------LLRQSSI--- --NSADGYSMYRYHFNGEE------LL----------------------FEEP-------ALST-------- ---------------------------------------SPGTVFR-----------------KKTCSF--- ------------------------------------RVKE-----------------EDVK----------- ----------------------------------------------------------------PHLDQPS- ---------------SLH-HTPG--------------PSPPATPGR-------------------------S R-----------------------------LAL----DGP-LSTELRPGLDPGISAGELD------------ -------------------------------------------PRADFKSAEVAPSL--------------- ------NTANVASTQLTVE-STVS-------------------------------------------HPLR- ESKLARY-----YP----GDLNTYKTMKSRSF-V-YSE---------------GRKLVR------------- ------------------------------------------------------------------------ ----------------------------------GLSNWG-------------------------------- ---------------AEYSSIMDQTW-----------------------------------------NSAEW RC-QVQRITRSR------------STDIPYI------------VSEAA------------------------ --------------------------------------SQDEFEDEH------------------------- -----------RESLLAP-------QISRSAL---TVSDR-------------------------------- ---------------P-EKENL-LSVKPHQT----------------------------------------- -----------LGFPCLRSRSLHGHPRS-------------------------------------------- ------------------------------------------------------------------------ ----------------------------------------------AKPSPSKLDRAGHAS----------- ------------------------------------------------------------------------ --------STSN--LA------------------------VMSDAPEGQ-NTQQEKGNPETEC--------- >RnorTRPM2/1-1508 ------------------------------------------------------------------------ --ME-------------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------PLDQ----------------RRTDSDQEEGF------------------ ---------------------------------GVQSRRATDLGMVPNLRRS-------------------- -----------------------------------------------------------NSSLCKSRRLL-- -----------------------------------------------------------------------C SFSSE------------------------------------------------------------------- -KQENLSS---------------------------------------------------------------- ----------------------------------------------WIPENIKKKE----------CVY--- ---------------------------------------------FVESSKLSDA----------------G KVVCECGYT-HEQH-----IEVAIKPHTFQ------------------------------------------ --GKEWDPKKHV---------------------------------------------------HEMPTDAFG DIVFTGLSQK---------------------------------VGKYVR----------------------- ------------------LSQDTSSIVIYQL-MTQH--------WGLDVPSLLISVTGGA-K-----NFNMK LRLKS---------------------------------IFRRGLVKVAQTT--------------------- -----------------------------------GAWIITGGSHTGV---------------MKQVGEAV- ---RDFSLSSS------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------CKE---------------- ------------------------------------------------------------------------ ---------------------GDVITIGI------------------------------------------- ----------------------------------------ATWG---------------------------- --------TIHNREAL-------------IHPM---GG---------------------------------- FPAEY-----MLDE-------------EGQGNLTCLDSNHSHFILVDDG-------------THGQYG-VE- ---------IPLRTKL--EK-------------FISEQTKERGGVA-------------------------- ----------------------------------IKIPI--VCVVLEGGPGTLHTIYN--AITNG------- ------------------------------------------------TPCVIVEG-----------S-GRV ADVIAQVAALPVSEITI-SL-------IQQKLSVFFQEMFETFTENQIV-------------EWTKKIQ--- -DIVRRR------QLLTVFREG---------------------------KDGQ-----QDV----------- -----------------------------DV-A-I--------------LQALLKA---------------- ---------SRSQDHFG-HENWDHQLKL-------------------------------------------- ------------------------------------------------------------------------ ------------AV------------------------AWNRVD---------------------------- ------IA------------RSEIFTDEWQWK---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------PSDL----------------------HPMMTAALIS----N------------------------K PEFVR--------------------------------LFLEN-G--VRLKEFVTW--------DTL------ --------------------------------------LCLYEN--------------LEPSCL-FHSKLQK --------------VLAEEHERLAYASETPRLQMHHVAQVLRELLGDSTQLLY------------PRPRYTD RPRL-------------------------------------------------------------------- ----SLP------------------------------MPHIKLN-VQGVSLRSLYKRSTGHVT-FTIDPVRD LLIWAI--------------IQNHR---------ELAGIIWAQSQDCTA----------------------- -AALACSKILKELSKEEED----------------------------------------------------- -------------------------TDSSEEML--ALADEFEHRAIGVFTECYRKDEE-------------R AQKLLVRVSE-------------------------------------------------------------- -------------------------------------------------AWGKTTCLQLALEAK-D-----M KFVSHGGIQ-----------AFLTKV--------------------------------------WW------ ----------------GQL---CVDNGLWRII------LCMLAFPLLFTGFISFR----------------- --EKRLQ----------------------------------------------------------------- ------------------------------------------------------------------------ --------------------------------------------------------------------ALCR PAR-------------VR----------AFFNAPVVIFYLNILSYFAFLCLFAYVL-------------MVD FQP--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------SPSWCEYLIYLWLFSLVC---------EETR-QL--FYD---PDGC-----------GLMK MASLYF-S----------DFWNKLDVGA-------------------ILLFIAGLTCRLIP----------- ---------------------------------------------------ATLYPGRIIL----SLDFIMF CLRLMHIFT----------------------------------------------ISKTLGP--KIIIVKRM MK-DVFFFLFLLAVWVVSF--GVAKQAILIHNE------------------SR------------------- -------------------------------------------VDW-IFRG--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------V----- ---------------------IYHSYLTIFGQIP--TY-ID---GV-NFSM-----DQCSPNG--------- -------TDPYKPKCPESDW--------------TGQAPA-FP--EWLTV----TLLCLYLLFANILLLNLL IAMFNYTFQEVQEHTDQIWKFQRHDLI------------------------EEYHGR--------------- ---PPAP-------PP--------------------LILLSHLQLLIK----------RIVL-------KIP AKRH---------------------------------KQLKNKLEK------NEEAALLSWELYLKENYLQ- -------------------------NQQYQHKQRP------------------------------------- ------------EQKIQDISEK-VDTMVDLLD------MDRVK----------------RSGSTEQRLASLE EQVTQMGRSLHWI----------------------------------------------------------- ------------------------VTT------------LKD--------SGF---GSGAGALTLAAQ---- --------------------------------------------RAFDEPDAE-------LS---------- --------------------------------------------------------------IRKKGEEGGD G------------------------------YHVSARHLLYPD-------------ARIMR-------FP-- VPN--------------------------------------------------------------------- -------------------------------------EKVPWEAEFL-IYDPPFY---------------TA EKKDAT-----------------------------------LTDPVGDTAEP-------------------- -------------------------------L---------------------------------------- -------------SKINYN---------------------------------------------VVDGLMDR CSFHGTY-------------------VVQYGF-P-LNPMGRTGLR--------GRGSLS------------- ------------------------------------------------------------------------ ---------------------------------WFGPNHT-------------------LQPVVTR------ ------------WKRNQGGGICRKSVR----------------------------------------KMLEV LV---MKLPQSE---------------------------------HWALP------------------GGSR EPGKMLPRKLKQVLQQEY--------------------------------------WVTFET---------- -------------------------LLRQGTEVYKGYVD---------------------------D----- ---------------P-RNTDN-------------------------------------------AWIETVA ----------------------------------------------------VSIHFQDQN----------- -------------------------------------------DVE----LKRLEENLQ------------- ---------------------------------------------THDPKESARGLEMSTEWQV-------- ------------------------------------------------------------------------ -------VDRRIPLYVNHKKILQKV--------------ASLFGAHF------------------------- >RnorTRPM3a/1-1721 ------------------------------------------------------------------------ --MGKKWRDA--------GEMERGCSD--------------------------------------------- ------------------------------------------------------------------------ ----REGS---------------------------------------------------------------- ----------------------------------AESRRRSRSASRGRFAES-------------------- --W------------------------------------------------------KRLSSKQGSTKR--- ----------------------------------------------SG------------------------ -------LP--------------------------------------------------------------A QQTPAQKS---------------------------------------------------------------- ----------------------------------------------WIERAFYKRE----------CVH--- ---------------------------------------------IIPSTK-DPH----------------- --RCCCGRL-IGQHVGL-TPSISVLQNEKNESR----------------------------------LSRND IQSEKWSISKHT---------------------------------------------------QLSPTDAFG TIEFQGGGHS--------------------------------NKAMYVR----------------------- ------------------VSFDTKPDLLLHL-MTKE--------WQLELPKLLISVHGGL-Q-----NFELQ PKLKQ---------------------------------VFGKGLIKAAMTT--------------------- -----------------------------------GAWIFTGGVNTGV---------------IRHVGDAL- ---KDHASK--------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------SRG---------------- ------------------------------------------------------------------------ ----------------------KICTIGI------------------------------------------- ----------------------------------------APWG---------------------------- --------IVENQEDL-------------IG-----RD---------------------------------- VVRPY----QTMS--------------NPMSKLTVLNSMHSHFILADNG-------------TTGKYG-AE- ---------VKLRRQL--EK-------------HISLQKINTRIGQ-------------------------- -----------------------------------GVPV--VALIVEGGPNVISIVLE--YLRDTP------ -----------------------------------------------PVPVVVCDG-----------S-GRA SDILAFGHKYSEEG-------GLINESLRDQLLVTIQKTFTYTRTQAQH-------------LFIILME--- --CMKKK------ELITVFRMG---------------------------SEGH-----QDI----------- -----------------------------DL-A-I--------------LTALLKGAN-------------- ---------ASAPD----------QLSL-------------------------------------------- ------------------------------------------------------------------------ ------------AL------------------------AWNRVD---------------------------- ------IA------------RSQIFIYGQQWP---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------VGSL----------------------EQAMLDALVL----D------------------------R VDFVK--------------------------------LLIEN-G--VSMHRFLTI--------SRL------ --------------------------------------EELYNT-------------RHGPSNT-LYHLVRD --------------------VKKGNLPPDYRISLIDIGLVIEYLMGGAYRCNYT-----------RKRFRTL YHNLFGPKR--------------------------------------------------------------- PKALKLLG---MED-------DIPLRRG--------------RKTTKKREEEVDIDLDDPEINHFP-FPFHE LMVWAV--------------LMKRQ---------KMALFFWQHGEEAMA----------------------- -KALVACKLCKAMAHEASEN---------------------------------------------------- ----------------------DMVDDISQELN--HNSRDFGQLAVELLDQSYKQDEQ-------------L AMKLLTYELK-------------------------------------------------------------- -------------------------------------------------NWSNATCLQLAVAAK-H-----R DFIAHTCSQ-----------MLLTDM--------------------------------------WM------ ----------------GRLR--MRKNSGLKVI------LGILLPPSIL--SLEFK----------------- -NKDDMPYMTQAQEIHL--------------------------QEKEPEEPE-------------------- ---KPTKEK-----------------------------DEEDMELTAMLGRNNG---ESSRKKD-------- ---------------------------------------------------------------EEEVQSRHR LIPVG-----------RKIY--------EFYNAPIVKFWFYTLAYIGYLMLFNYIV-------------LVK MER--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------WPSTQEWIVISYIFTLGI---------EKMR-EI--LMS----EPG-----------KLLQ KVKVWL-Q----------EYWNVTDLIA-------------------ILLFSVGMILRLQ------------ -------------------------------------------------DQPFRSDGRVIY----CVNIIYW YIRLLDIFG----------------------------------------------VNKYLGP--YVMMIGKM MI-DMMYFVIIMLVVLMSF--GVARQAILFPN-------------------EE------------------- -------------------------------------------PSWKLAKN--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------I----- ---------------------FYMPYWMIYGEVF--ADQIDRKQ---VYDSHTPKSAPCGQNETRED----- ----GK-TIQLPP-CKTGA---------------------------WIVP----AIMACYLLVANILLVNLL IAVFNNTFFEVKSISNQVWKFQRYQLI------------------------MTFHER--------------- ---PVLP-------PP--------------------LIIFSHMTMIFQ----------HVCC-------RWR --KH----------------ESDP---------DERDYGLKLFITD------DELKKVHDFEEQCIEEYFR- -------------------------EKDDRFNSSN------------------------------------- ------------DERIRVTSER-VENMSMRLEEVNEREHSMKA----------------SLQTVDIRLAQLE DLIGRMATALERL-----------------------------------TGLERAESNKIRSRTSSDCTD--- --------------------------------------------------AAY---------IVRQSSF--- --NSQEGNT-----FKLQE------SID-------------------PAGEET-------MSPT-------- ---------------------------------------SPTLMPR-----------------MRSHSFYS- -----------------------------------VNVKDKGG-------------IEKLE----------- ----------------------------------------------------------------SIFKERSL ---------------SLH-RATSSHSV--AKE-----PKAPAAPANT------------------LAIVPDS RRPSSCIDIYVSAMDELHCDIDPLDNSMNILGL----GEP-SFSALAPSTAPSSSA---------------- --------------------------------------------YATLAPTDRPPS---------------- --------RSIDFEDLTSM-DTRSF--SSDYTHLPECQNPWDT---------DPPM----------YHTIE- RSKSSRYL--ATTP----FLLEEAPIVKSHSF-M-FSP---------------SRSYYAN------------ ------------------------------------------------------------------------ ---------------------------------FGVPVKT-------------------------------- ---------------AEYTSITD------------------------------------------------- -C------IDTR------------CVNAPQA------------IADRATF----PGGLGDKVEDLSCCHPER EAE-------------------------------LSHPSSDSEENEA------------------------- -----------RGRRAAN-------PISSQET---ENADR-------------------------------- ---------------T-LSNNI-TVPKIERA----------------------------------------- -----------NSYSAEEPSAPYAHTRK-------------------------------------------- ------------------------------------------------------------------------ ----------------------------------------------SFSISDKLDRQRNTA----------- ------------------------------------------------------------------------ --------SLRNPFQR------------------------SKSSKPEGRGDSVSMRRLSRTSAFHSFESKHN >RnorTRPM4/1-1208 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------MVG---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --QEKEQS---------------------------------------------------------------- ----------------------------------------------WIPKIFRKKV----------CTT--- ---------------------------------------------FIVDLH-DDA----------------G GTLCQCGQP-RDAHPSV-AVEDAFGAAVV------------------------------------------- ---TEWNSDEHT---------------------------------------------------TEKPTDAYG DLDFTYSGRK---------------------------------SSNFLR----------------------- ------------------LSDRTDPATVYSL-VTRS--------WGFRAPNLVVSVLGGS-E-----GPVLQ TWLQD---------------------------------LLRRGLVRAAQST--------------------- -----------------------------------GAWIVTGGLHTGI---------------GRHVGVAV- ---RDHQTAST------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------GGS---------------- ------------------------------------------------------------------------ ----------------------KVVAMGV------------------------------------------- ----------------------------------------APWG---------------------------- --------VVRNRDML-------------INPK---GS---------------------------------- FPARYRWRGDPED-----------------GVEFPLDYNYSAFFLVDDG-------------TYGRMG-GE- ---------NRFRLRF--ES-------------YVAQQKTGVGGTG-------------------------- ----------------------------------IDIPV--LLLLIEGDEKMLKRIED--ATQAQ------- ------------------------------------------------LPCLLVAG-----------S-GGA ADCLVETLED---TLAP-GSGGLRRGEARDRIRRYFPK--GD----------------------PEVLQAQV ERIMTRK------ELLTVYS-S---------------------------EDGS-----EEF----------- -----------------------------ET-I-V--------------LRALVKACG-------------- -----------SSE----ASAYLDELRL-------------------------------------------- ------------------------------------------------------------------------ ------------AV------------------------AWNRVD---------------------------- ------IA------------QSELFRGDIQWR---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------SFHL----------------------EASLMDALLN----D------------------------R PEFVR--------------------------------LLISH-G--LSLGHFLTP--------VRL------ --------------------------------------AQLYSA--------------VSPNSL-IRNLLDQ ASH-------------ASS-SKSPPANGAAELRPPNVGQVLRTLLGETC--------------APRYPARNT RHSLLGQDH--------------------------------------------------------------- RENDSLL------------------------------MDWANMQ--QDASFEQA--------------PWSD LLIWAL--------------LLNRA---------QMAIYFWEKGSNSVA----------------------- -SALGACLLLRVMARLEWE----------------------------------------------------- -------------------------AEEAARRK--DLAAKFESMSVDLFGECYHNSEY-------------R AARLLLRRCP-------------------------------------------------------------- -------------------------------------------------LWGEATCLQLAMQAD-A-----R AFFAQDGVQ-----------SLLTQK--------------------------------------WW------ ----------------GEM---DSTNPIWALL------LTFFCPPLIYTNLILFR----KSEEEP------- -TQKDLD----------------------------------------------------------------- ----------------------------------------FDMDSSM------------------------- ---NGAGPLGPAE--------------------------------------------------PSAKVALER RRRRRPGHTLCCGGCSKRWS--------YFWGAPVTAFLGNVVSYLLFLLLFAHVL-------------LVD FQ---------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------PTKPGVFELLLYFWAFTLLC---------EELR-QG--LGG---GWGTLANGGPGPGKAPLRH RLHLYL-L----------DTWNQCDLLA-------------------LTCFLLGVGCRLTP----------- ---------------------------------------------------GLFDLGRTVL----CLDFMIF TLRLLHIFT----------------------------------------------VNKQLGP--KIVIVSKM MK-DVFFFLFFLCVWLVAY--GVATEGILRPQD------------------RS------------------- -------------------------------------------LPS-ILRR--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------V----- ---------------------FYRPYLQIFGQIP--QEEMD---VA-LMNP-----SNCSAER--------- -------GSWAHP---EGPV--------------AGSCVSQYA--NWLVV----LLLIVFLLVANILLLNLL IAMFSYTFNKVHGNSDLYWKAQRYSLI------------------------REFHSR--------------- ---PALA-------PP--------------------LIIISHLRLLFK----------WL----------RR CHRT----------------NLPA---------SPVFEHFRVCLSK------EAERTLLTWESVHKENFLL- -------------------------AQARDKRDSD------------------------------------- ------------SERLKRTSQK-VDTALKQL-----------G----------------QIREYDRRLRGLE REVQHCSRVLTWM----------------------------------------------------------- ------------------------AEA------------LSH--------S----------ALL-------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------PP------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------GG-P-PPPS--------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------P------------------TGSK D----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >RnorTRPM5/1-1156 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --MPMAQS---------------------------------------------------------------- ----------------------------------------------SCP----------------------- ------------------------------------------------------------------------ ------GSP-PD-------TGDG------------------------------------------------- -----W-----------------------------------------------------------EPVLCKG EVNFGGSGKK---------------------------------RSKFVK----------------------- ------------------VPSNVAPSMLFEL-LLTE--------WHLPAPNLVVSLVGEE-R-----LFAMK SWLRD---------------------------------VLRKGLVKAAQST--------------------- -----------------------------------GAWILTSALHVGL---------------ARHVGQAV- ---RDHSLAST------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------STK---------------- ------------------------------------------------------------------------ ---------------------VRVVAIGM------------------------------------------- ----------------------------------------ASLD---------------------------- --------RILHRQLLD-----------GV--Q---ED---------------------------------- TPIHY-----PADE------------GSTQGPLCPLDSNLSHFILVEPG-------------TLGSGNDGL- ---------AELQLSL--EK-------------HISQQRTGYGGTSS------------------------- ----------------------------------IQIPV--LCLLVNGDPSTLERMSR--AVEQA------- ------------------------------------------------APWLILAG-----------S-GGI ADVLAALVGQP-HLLVP-QV-------TEKQFREKFPS--ECFSWEAIV-------------HWTELLQ--- -NIAAHP------HLLTVYDFE---------------------------QEGS-----EDL----------- -----------------------------DT-V-I--------------LKALVKACK-------------- ---------SHSRD----AQDYLDELKL-------------------------------------------- ------------------------------------------------------------------------ ------------AV------------------------AWDRVD---------------------------- ------IA------------KSEIFNGDVEWK---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------SCDL----------------------EEVMTDALVS----N------------------------K PDFVR--------------------------------LFVDS-G--ADMAEFLTY--------GRL------ --------------------------------------QQLYHS--------------VSPKSL-LFELLER KHEEGRLTLA---GLGAQQ-TRELPV-GLPAFSLHEVSRVLKDFLHDACRGFYQDGRRMEERGPPKRPA--- -----GQ----------------------------------------------------------------- ----KWL------------------------------PDLSRKS--ED--------------------PWRD LFLWAV--------------LQNRY---------EMATYFWAMGREGVA----------------------- -AALAACKIIKEMSHLEKE----------------------------------------------------- -------------------------AEVARTMR--E--AKYEQLALDLFSECYSNSED-------------R AFALLVRRNH-------------------------------------------------------------- -------------------------------------------------SWSRTTCLHLATEAD-A-----K AFFAHDGVQ-----------AFLTKI--------------------------------------WW------ ----------------GDM---ATGTPILRLL------GAFTCPALIYTNLISF------SEDAP------- -QRMDLEDLQEP------------------------------------------------------------ --------------------------------------DSLDMEKSFLCSHGGQLE---------------- KLTEAPRAPGDLG--------------------------------------------------PQAAFLL-- ----------------TRWR--------KFWGAPVTVFLGNVVMYFAFLFLFSYVL-------------LVD FRPP-------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------PQGPSGSEVTLYFWVFTLVL---------EEIR-QG--FFT---NEDT-----------RLVK KFTLYV-E----------DNWNKCDMVA-------------------IFLFIVGVTCRMVP----------- ---------------------------------------------------SVFEAGRTVL----AIDFMVF TLRLIHIFA----------------------------------------------IHKQLGP--KIIIVERM MK-DVFFFLFFLSVWLVAY--GVTTQALLHPHD------------------GR------------------- -------------------------------------------LEW-IFRR--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------V----- ---------------------LYRPYLQIFGQIP--LDEID---EA-RV--------NCSL----------- -----------HPLLLDS----------------SASCPNLYA--NWLVI----LLLVTFLLVTNVLLMNLL IAMFSYTFQVVQGNADMFWKFQRYHLI------------------------VEYHGR--------------- ---PALA-------PP--------------------FILLSHLSLVLK----------QVFR-------KEA QHKQ---------------------------------QHLERDLPD------PVDQKIITWETVQKENFLS- -------------------------TMEKRRRDSE------------------------------------- ------------EEVLRKTAHR-VDLIAKYI-----------G----------------GLREQEKRIKCLE SQANYCMLLLSSM----------------------------------------------------------- ------------------------TDT------------LA------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------P------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------GG-T-YSSSQNCGRR--------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------SQP------------------ASAR DREY-----LEAGL---------------------------------------------------------- ------------------------------------------------------------------P----- ---------------H-SDT---------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >RnorTRPM6/1-2024 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --MQVKKS---------------------------------------------------------------- ----------------------------------------------WIERVFYKRE----------CNK--- ---------------------------------------------FIPSSK-DPHRCT--PGCQICQNLV-- --RCYCGRL-IQEHQGL-DRAWSLSATE-------------------------------------------G NGNEQWSVEKHT---------------------------------------------------VKSPTDTFG TINFQDGEHI--------------------------------YHSKYIR----------------------- ------------------TSWDTKSDHLLHL-MLKE--------WNMELPKLVISVHGGL-Q-----NFKMP SKLKE---------------------------------TFSQGLVKAAETT--------------------- -----------------------------------GAWIITEGINSGV---------------SKHVGDAL- ---KAHSSM--------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------SLR---------------- ------------------------------------------------------------------------ ----------------------KIWTVGI------------------------------------------- ----------------------------------------PPWG---------------------------- --------VIENQREL-------------VG-----KD---------------------------------- VVCMY----QTLS--------------NPLSKLTTLNCMHSHFILCDDG-------------TVGKYG-NE- ---------EKLRRNL--EK-------------HLSMQKIHTCSRQ-------------------------- -----------------------------------GVPV--VGLVVEGGPNVILWVWE--TVRNKE------ -------------------------------------------------PVVVCEG-----------T-GRA ADLLAFTYKHSEDG-------GILRPQVKEEILCLIQNMFNFSLRQSKH-------------LFQILME--- --CMVHK------DSITIFDAD---------------------------SEEH-----QDL----------- -----------------------------DL-A-I--------------LKALLKGTS-------------- ---------LSISE----------QLNL-------------------------------------------- ------------------------------------------------------------------------ ------------AM------------------------AWDRMD---------------------------- ------IA------------KKHILIYGQHWK---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------PGAL----------------------EQAMRDALVM----D------------------------R VDFVK--------------------------------LLIEN-G--VNLHRFLTI--------SRL------ --------------------------------------EDLYNT-------------KQGPTNKFLRHLVQD --------------------VKQHTLLSSYRITLIDIGLVIEYLIGGAYRSSYT-----------RKSFRVL YNDL----Y------------RKHKGMTSFAQ------------GLSQHPLHQRH-SLG--------NRK-- ESSESTLHSQFFRT-------AQPYKSKD---------KPEDSHKPKKKSKERHSLSEDPGSAGFI-YPYND LLVWAV--------------LMKRQ---------KMAMFFWQHGEEATV----------------------- -KAVIASILYRAMAREAKES---------------------------------------------------- ----------------------NMVDDTSEELK--KYSEQFGQLALDVLEKAFKQNEP-------------M AMKLLTYELK-------------------------------------------------------------- -------------------------------------------------NWSNSTCLKLAVSGG-L-----R PFVSHSCTQ-----------MLLTDM--------------------------------------WM------ ----------------GRLK--MRKNSWLKII------ISILLPPMIL--TLEFK----------------- -SKAEMSHVPQSQD-FQF------------------------TWNYSDQGLS-------------------- ---NTKEA----------------------------------KDYDLERGPDEKLD-EALHLDL-------- -------------------------------------------------------------------RNVPQ SLPWT-----------RRVY--------EFYSAPFVKFWFYTMAYLAFLMLFTYTV-------------LVE MQP--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------QPSVQEWLVIIYIFTNAI---------EKVR-EI--CIS----EPS-----------KFTQ KVKMWL-S----------EYWNLMETVA-------------------IGLFAVGFGLRWG------------ -------------------------------------------------HPPLHTAGRLIY----CIDIIFW FSRLLDFFA----------------------------------------------VNQHAGP--YVTMIAKM AA-NMFYIVIIMAIVLLSF--GVARKAILSPK-------------------EP------------------- -------------------------------------------PSWRLARD--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------I----- ---------------------VFEPYWMMYGEVY--ASEID----V------------CSN----------- -------ETS----CPPGS---------------------------FLTP----FLQAVYLFVQYIIMVNLL IACFNNIYLDIKSISNKLWKYNRYRYI------------------------MTYHQK--------------- ---PWLP-------PP--------------------FILISHLCLLLR---------GLCCR---------- --PA----------------PQDQ---------EEGDMGLKLYLTK------DDLKKLHDFEEQCVEKYFH- -------------------------EKTEGLNCSC------------------------------------- ------------EEQIRATSER-VSEMFFQLKEMNEKVSFIKD----------------SLLSLDSQVGHLQ DLSALTVDTLKVLSAVDTLQED------EILLANRKHSTC-------------------RKRPHSWTNVI-- -----------------------CAKV------------LTD--MESCGKQKF-QYYSMPPSLLRSLA---- -------------RSQLPPGVQRGALVEVTHNTREASH------VREDQKERE-------VEQRTIASGVSH VRQAHSKYGQFLLVPPSEKQVSL------------SLENPPHL-------------------FRASGETGTD DVALQHRHPSDVTIHLPGQTPAVSHQALGAEHKDQHEAVIQMS-------------GKPDKAEQDSLKFS-G TPA-PMAVTSLPSRAISMQDEGGYVNWAFSESDEAGVFSFKKKWKTCLASTCDSGSKPGGDCSLQAAGRSGL ---------------DNS-RLAQSCEW----------PAGPWTQARRSFWINPLCRDKPLLKSHSFRFHKEE KLRKTW-----------------------------------KNNSHSKASETGSTWLKAKLLT--------- ---------------------------KNRSLSKKR-------RKAQGLQVPVITVN--------------- ------ACYQS--DQLTSE-SGETN--TTEDYSKN-----WLSVSNFSQIGLEPYIYQKMKMKEIERHTTQ- ASYHLRQ--MQEDP------DKNPS-WNSRSA-S-VSRSFL------------TRS---------------- ------------------------------------------------------------------------ ------------------------------------PNEVDKISASLKS---------PPEP---------- --------------HRHYSAIERNNL-----------------------------------------MRLSQ TI------PFTPIQLF------TGEEVTIYKLEETSPLTLDKSMSSWSQH------GRAAIIQVL------- SQEE-----MDGGLRKAM---------------RVISTWSEDD---------------VLKPGQVFIVKSFL PEVVQTWYKIFQESTVLHL------CLREIQQ--QRAAQKLIY----------TF-------------NQVK ---------------P-QTIPY--TPRFLEV-------------------------------SL-VYCHSAN -----------QWLTIEKYMTGEFRKYNNNNGDEIAPTNTL---------EELML---------AFSHWTYE YTRGEL----------------------------------LVLD------LQGVGENL-------------- ----------------------------------------------TDPSVIKPEDKQSRGMVFGPANLG-- ---------------------------------------------------EDAIRSFIA-----------K HRCNSCCGKLRLPDLKRNDYSHAR--------AHCNLELAKTTEPAEEHPERDRNRSPLEDHTRL------- >RnorTRPM7/1-1862 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---MSQKS---------------------------------------------------------------- ----------------------------------------------WIESTLTKRE----------CVY--- ---------------------------------------------IIPSSK-DPHRCL--PGCQICQQLV-- --RCFCGRL-VKQHACF-TASLATKYSDVKLG------------------------------------EHFN QAIEEWSVEKHT---------------------------------------------------EQSPTDAYG VINFQGGSHS--------------------------------YRAKYVR----------------------- ------------------LSYDTKPEIILQL-LLKE--------WQMELPKLVISVHGGM-Q-----KFELH PRIKQ---------------------------------LLGKGLIKAAVTT--------------------- -----------------------------------GAWILTGGVNTGV---------------AKHVGDAL- ---KEHASR--------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------SSR---------------- ------------------------------------------------------------------------ ----------------------KICTIGI------------------------------------------- ----------------------------------------APWG---------------------------- --------VIENRNDL-------------VG-----RD---------------------------------- VVAPY----QTLL--------------NPLSKLNVLNNLHSHFILVDDG-------------TVGKYG-AE- ---------VRLRREL--EK-------------TINQQRIHARIGQ-------------------------- -----------------------------------GVPV--VALIFEGGPNVILTVLE--YLQESP------ -----------------------------------------------PVPVVVCEG-----------T-GRA ADLLAYIHKQTEEG-------GNLPDAAEPDIISTIKKTFNFGQSEAVH-------------LFQTMME--- --CMKKK------ELITVFHIG---------------------------SEDH-----QDI----------- -----------------------------DV-A-I--------------LTALLKGTN-------------- ---------ASAFD----------QLIL-------------------------------------------- ------------------------------------------------------------------------ ------------TL------------------------AWDRVD---------------------------- ------IA------------KNHVFVYGQQWL---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------VGSL----------------------EQAMLDALVM----D------------------------R VSFVK--------------------------------LLIEN-G--VSMHKFLTI--------PRL------ --------------------------------------EELYNT-------------KQGPTNPMLFHLIRD --------------------VKQGNLPPGYKITLIDIGLVIEYLMGGTYRCTYT-----------RKRFRLI YNSLGGNNR------------RSGRNASS-----------------STPQLRKSHETFG--------NRA-- DKKEKMRHNHFIKT-------AQPYRPKM---------DASMEEGKKKRTKDEIVDIDDPETKRFP-YPLNE LLIWAC--------------LMKRQ---------VMARFLWQHGEESMA----------------------- -KALVACKIYRSMAYEAKQS---------------------------------------------------- ----------------------DLVDDTSEELK--QYSNDFGQLAVELLEQSFRQDET-------------M AMKLLTYELK-------------------------------------------------------------- -------------------------------------------------NWSNSTCLKLAVSSR-L-----R PFVAHTCTQ-----------MLLSDM--------------------------------------WM------ ----------------GRLN--MRKNSWYKVI------LSILVPPAIL--MLEYK----------------- -TKAEMSHIPQSQDAHQM------------------------TMEDSENNFH-------------------- ---NITEEIP----------------------------MEVFKEVKILDSSEGKNE-MEIHIK--------- ----------------------------------------------------------------------SK KLPIT-----------RKFY--------AFYHAPIVKFWFNTLAYLGFLMLYTFVV-------------LVQ MEQ--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------LPSVQEWIVIAYIFTYAI---------EKIR-EV--FMS----EAG-----------KISQ KIKVWF-S----------DYFNVSDTIA-------------------IISFFVGFGLRFGAKWNYIN----- --------------------------------A-------------YDNH--VFVAGRLIY----CLNIIFW YVRLLDFLA----------------------------------------------VNQQAGP--YVMMIGKM VA-NMFYIVVIMALVLLSF--GVPRKAILYPH-------------------EE------------------- -------------------------------------------PSWSLAKD--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------I----- ---------------------VFHPYWMIFGEVY--AYEID----V------------CAN----------- -------DSALPTICGPGT---------------------------WLTP----FLQAVYLFVQYIIMVNLL IAFFNNVYLQVKAISNIVWKYQRYHFI------------------------MAYHEK--------------- ---PVLP-------PP--------------------LIILSHIVSL------------FCCI---------- --CK----------------RRKK---------DKTSDGPKLFLTE------EDQKKLHDFEEQCVEMYFD- -------------------------EKDDKFNSGS------------------------------------- ------------EERIRVTFER-VEQMSIQIKEVGDRVNYIKR----------------SLQSLDSQIGHLQ DLSALTVDTLKTLTAQKASE------------ASKVHNEI--------------------TRELSISKHL-- -----------------------AQNL------------IDDVPVRPMWKK---------PSVVNTLS---- --------------SSLPQG------------DRESNNPFLCNIFMKDEKDPQ------------------- ----YNLFGQDLPVIPQRKEFNIPEAGSSCGALFPSAVSPPELRQRRHG-------VEMLKIFNKNQKLGSS ----------------PNSSP-------------------HMS-------------SPPTK-------FSVS TPSQPSCKSHLES--TTKDPEPIFYKAAEGDNIEFGAF---------------------------VGHRDSM ---------------DLQ-RFKET----------------------------------------------SN KIRELL-----------------------------------SNDTPENTLK--------------------- -------------------------------------------------HVGAAGYN--------------- ------ECHK-------------TP--TS-------------------------------------LHSEQ- ESCSRRA--STED---------SPD-VDSRAA-L-LPDWLR------------DRPTNR------------- ------------------------------------------------------------------------ ----------------------------------EMPSEGGTLN-GLAS---------PFKPVLD------- -------------TNYYYSAVERNNL-----------------------------------------MRLSQ SI------PFVPVPP-------RGEPVTVYRLEESSPSILNNSMSSWSQL------GLCAKIEFL------- SKEE-----MGGGLRRAV---------------KVLCTWSEHD---------------VLRSGHLYIIKSFL PEVINTWSSIYKEDTVLHL------CLREIQQ--QRAAQKLTF----------AF-------------NQMK ---------------P-KSIPY--SPRFLEV-------------------------------FL-LYCHSAG -----------QWFAVEECMTGEFRKYNNNNGDEIIPTNTL---------EEIML---------AFSHWTYE YTRGEL----------------------------------LVLD------LQGVGENL-------------- ----------------------------------------------TDPSVIKAEEKRSCDMVFGPANLG-- ---------------------------------------------------EDAIKNFRA-----------K HHCNSCCRKLKLPDLKRNDYTPDKIIFPQDESSDLNLQAGNSTKESEA-----------TNSVRLML----- >TcIav/1-1071 ------------------------------------------------------------------------ --MGAKVCKP-------------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------------------CKK------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------RKANTF------ ------------------------------------------------------------------------ --------------------------------------------------------------QGGSIL---- DRVISQAS---------------------------------------------------------------- ---------------------------------------------NQDQCLLYKLA---------------- ------------------------NYKKGGELIDA------------------------------------- --------YNQGGQ---------------------------------------------------------- ------AEVEKL------------------------------------------------------------ ------------------------------------------IREQFGQL---------------------- --------------------------------MYQE---------------------GKG-Q-----IINRS EYLRWKFRD--------------------------------------HEQVILPIE---------------- --------------------------------------------------------------------ASL- ---SRYDPL--------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------AK----------------- --------------------------------------------WND------------------------- -------------------------------------------------------------HE--------- ----------------------------------------ACWQ---------------------------- ---------MQFRGSLG-------------------E----------------------------------- SLLHV-------------------------------------LIIC-------------------------- ------------------------------------------------------------------------ -----------------------------------DTKI--HTR-------LARTLIK-------------- ---CF---------------------------------------PKLALDVVEGEEYL-----------GAS ALHLAI------------------------------------------------------------------ --AYNN------NELVQDLVE-----------------------------AGA------NVNQRAIGSFFLP RDQQRQKP-------------------AKH--T-----DYEGLAY--LGEYPLAWAAC-------------- ---------CANESVY--------NLLLDS-GAH-------------------------------------- ------------PD---------------------------------------------------------- ----YQDNFGNMIL--------HMVVV---------CDKLDMFG---------------------------- ------YALR------HPKLPASNGIVN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---KAG-SPV-------------------------------------------------------------- --------------------------------------MLEL---------SAKE-------FWRY------ --------------------------------------SNITCSA--------------------------- -------------------------------------------YFLNALDTLLP------------------ -------------------------DGRT------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -NWNSALFII-------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ LNGTKEE----------------------------------------------------------H-----L AMLDGGIIQ-----------RLLEEK--------------------------------------WK------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------T------------------- ---------------FARNQ-----------------FLKRLLILVVHLLFLSLAV-------------YLR PD---------------------------------------------------------------------- -------------------------------DPDES------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------LLT----------WSDD-- -----------VTLI---ARYVCEVGTIL---------GVLS-YL-VLQQ--------GDE-------IRNQ GLTAFL-K----------QQLNSPPKLI----------------------FLISNFLILACIPCRLY----- -----------------------------GDKE--------------TEE--------AIL----CFAVPGS WFLLMFFAG----------------------------------------------AVRLTGP-FVTMIYSMI TG-DMLTFGIIYTVFLFGF--SQSFYFLY----------------------KGF------------------ PGVKT-----------------------------------------SLYNT-Y------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------MST----- ---------------------WMALFQITLGNYE--YSELSAT----------------------------- ----------------------------------------TY---PAVSK----TVFAIFMVFVPILLLNML IAMMGNTYAHVIEQSEKEWVKQWAKIV------------------------IALERAIPQSDAQHYLQ---- --EYSISLGPSEQ--D---------------------PSTEKRGVLVI---------KSKSK---------- -TRA----------------KQRKGA----------VANWKRV------------------GKVTINALKKR GLTGEEMRCLMWG-RESIN-------TPVKTKKPVKDP-------------LLDPQGPNLT----------- ---------------GGFGDAL-TTALDV-MTFT-HDLDI-----------------VGASQGL-------- ----------------------------------NLATNPKPVPPTTTASAVTVNNQINSALNAQQKAVAGA GVGALAMI-GTVTQLTDSQGYIMQNSV---KKEE---KIVAT--LEDPFR-----------ELVINAND--- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------SNCDP----------------------EK---------- ---------------------------------------------------------------LKMLALS-- --------------AANLKDVEELSVAKPQTK-----------SV--------------------KSLAGIF AGTETFV------------------------------------RKVEETIKKKY-----------AALDPSD ----SEGFG------------------EPPLLGK-------------------------------------- ---------ISRTRRAKSANLRNS------SARSKA------------------------------------ ---SDKK--KLVAG------------SQSSSTDT-------------------------------------- --------------------------------------------------------------------VNN- ------------------------------------------------------------------------ -------------------EINEKNI---------------------------------------------- -----------------------------------ENS-DLDYAEERI----------------KLVKESLK QV------------------------------VDVAQIRPINI-------------DVALEE---------- ---------------------------QVSVT--ISETMRVQG-S--------------GDGAEVQS-SNVK ---------------P-------------------------------------------------------- -------------KRKKRSKTAKNNK---------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >TcNan/1-796 ------------------------------------------------------------------------ --MGNTESNV-------------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------------------TSG------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------VKKQA------- ------------------------------------------------------------------------ --------------------------------------------------------------GASV------ ------------------------------------------------------------------------ -------------------------------------------------QPIYKLC---------------- ------------------------DLKGGGLLVEL------------------------------------- --------MKRATQNK-------------------------------------------------------- ----QYAELDHA------------------------------------------------------------ ------------------------------------------IKTKVEHF---------------------- --------------------------------LYNK---------------------GAG-R-----YFTIS DLVLLRNKER-------------------------------------SRQKWLPQL---------------- --------------------------------------------------------------------KAM- ---ENP------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------ED----------------- --------------------------------------------FEI-DDE-----------GPEITEEQYQ K--------------------------------NPHLY-----------------------RH--------- ----------------------------------------VCWK---------------------------- ---------IKERGAVG-------------------E----------------------------------- SIMHL-------------------------------------CLLN-------------------------- ------------------------------------------------------------------------ -----------------------------------ATSL--HAD-------IAKRLLR-------------- ---FY---------------------------------------PKLINDIYMSDEYY-----------GEN VLHIAI------------------------------------------------------------------ --VNED------PSMVKFLLD-----------------------------SGV------NIQERCCGNFMCP EDQKSSRYDS---------LDHEWVNVCPV--T-----NYEGYVY--WGEYPLTFAAC-------------- ---------LGQEESF--------RLMLSR-GAD-------------------------------------- ------------PD---------------------------------------------------------- ----AQDTNGNTVL--------HLLVI---------LQKLEAFD---------------------------- ------MAY---------EVGAKLSIRN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---VLSLTPL--------------------------TLAAKL----A------------------------R IDMFF--------------------------------HILNL---------EREI-------YWQIV----- -------------------------------------LGSITCAA--------------------------- -------------------------------------------YPLSQIDTIDI------------------ ------------------------ETGQI------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -SKTSALNLV-------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ VFGDKDE----------------------------------------------------------H-----L ELMDG-VLI-----------DLLNAK--------------------------------------WN------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------T------------------- ---------------FVKFK-----------------FYKQFFTFAFYFLISLVAF-------------TLR PG---P-------------PHK-------------------------------------------------- -EAKL--V----NVTINATV-------S---NTS---------------------------KWENLTSIP-- ------------------------------------------------FGKT-------------------- ------PDDD------DSD-------------------MEEWWDNLQEE--CRLMQ-------LESPESK-- ------------------IRLTAEVLMVV---------GAFA-YL--AAA--------VRE-------ARFL GGRMFF-E----------NLMTAPSRVM----------------------FLFSCILMLTVPCLRLA----- -----------------------------CLDE--------------FED--------IVA----VVIMLTT APYFLFFCR----------------------------------------------GFKTVGP-FVVMIYRMV MG-DLIRFASIYLVFVMGF--SQAFYIIF----------------------LSF------------------ DNPLT------------PDDVDDS--------------------ATNPIST-P------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------IES----- ---------------------IMAMFLMSMTNFGDYYAAFEKT----------------------------- ----------------------------------------DH---EYEAK----MLFVVFMVIVSILLINML IAMMGNTYQK-IAETRNEWQRQWARIV------------------------LVVERGVSPSERLKQLM---- --VYSQPMSDGRR-----------------------------ALVLRL---------NQS-D---------- -EDK----------------EEMKEI-----------LEMRRR------------------HERHIKKRSEK LK---------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------------ENAKK N----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >TcNompC/1-1823 ------------------------------------------------------------------------ --MSQP------------------------------------------------------------------ ------------------------------------------------------------------------ -AGKKGGGK--------------------------------------G------------------------ ----------------------------PPKDKNDDSKDQNNKAAKDSKEKDKEETASN------------- ---------PEGDDT-------------------------------------------PSSKP--------- ----------------------------------------------QSAGAN----------VRDAAQR-IL VLCQKGEWA-----PVDQVLKSLEKSIAAAG-DDANTVPLAGVADLATGMTPLMYAVKDNR---TSLL---- DKLIDLGSDVGARNNDNYNVLHISAMYS----REDVVKLLLTKRGVDPYSTGGSRNQTAVHLVASRQTGTAT AILRALLQAAGKDIRLKPD-------------GRGKIPLLLAVEAGNQS-MCREL--L-------------- -------------------------SAQTAEQLK-----------AA-AANGDTA----------------- --------LHLAVR---------RKDIDMVRILVDYGT---------------------------------- ----SVDIRNGE---------------------------------------------------GQTPLHIAA ---------------------------------AEGDEA--------------------------------- -----LVKYFYGVR----ASASVTDNQDRTP-MHLA-AEN-----------------GHA-N--------II ELLADKFK-A--------------------------------SIFERTKDG--------------------- --------------------------------------------STLMHIASLNGHADCAAMLFKK-GVYL- ---HMPNK---------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------DGA--------------------------------------------------------- RSIHT---------------------AARYG-----HVGIINTLLQ--------------------KG-EK- ---------VDVTTN---ENYTAL---------HIAVESAKPAVVETLLGYGADVHVRGGKLKETALHIAAR VKD--GDRCALMLLKSGAGPNLTTHDG--------QTPV--HVAAQYGNLQTLLLLLE-----DGGDPQFKN K-------AGETALHLASRGCRP---DVVQHLINYLKEHKGDEVAAS--YINEISE-----------H-DES ALHYVSAVKK-------------------------------------------------------EDVE--- -VPLADK------EVVKLLLQ-----------------------------NGA------DVKLQTKQH-ETA FHYVAKAGNNDVLMEMIAHMTPNDVQKALNK-Q-----NLTGW-------TPLLIASH-------------- ---------KGHQEMV--------NNLLSN-HAR-VDVFDNEGRSALHLAAEHGYLQVCDFLLSN------- --------------------------------------------KAFIN----------------------- ----SKSRNGRTAL--------HLAAM---------NGYIHLVKFLIKDHNAVIDILTLKKQTPLHLAAAAG QIEVCRLLL---------ELGADIDATDEQGQKPIHAACQNNFSEVAKLFLQ---QHPSLVMATTKDGNTCA HIAAAQGSVTVIEELMKFDRQGVISARNKLTDATPLQIAAEGGHAEVVKALVRAGASVTDENKGGFTAVHLA AQNGHGQVLEV-LR--SSNTLRVTSKKLGVTPLHVAAYFGQADTVRELLTHVPGTVKSEPPN---GASLVPA LGNESGMTPL--------------------------HLASFS----G------------------------N ENVVR--------------------------------LLLNSAG--VQVDAATHE-------NGY------- --------------------------------------NPMHLAC------------YGGHVTV-VGLLLSR SAE-----------------------------------------LLQSHDK-H------------------- --------------------------GKT------------------------------------------- --------------------------------------------------------------------GLHI AAT------------------HGHY---------QMVEVLLGQGAEINA-PDK------------------- -NGWTPLHCA---SRAG---------------------------------------CFEVVKLLTESGASPK SETNLGAVPIWFAASEGHH------DVLEYLMT--KE----HDTYALMEDR--------------------- ---RFVYNL------------MVCS----KNHNNKPIEEFILVSPAPVDTA-AKLSNILIVLSGKEKERAKD LISAGKYC-----------------EAMATELLALAAGADSAGKILTATDRRNVEFLDVLIENE-Q-----K EVIAHTVVQ-----------RYLQEL--------------------------------------WR------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------G------------------- ---------------ALNWA-----------------AWRTLLLFVLFIICPPVWI-------------AFT L----------------------------------------------------------------------- --------------PLGHKY-------Y---KV--------------------------------------- ------------------------------------------------------------------------ ----------------------------------------------------PIIKFM-------------- -----------SYLTSHIYLMLFLLIVGI---------TPPY-PV--VRK---------N------------ -------L----------LP-YSYEWILLIWLSGLLLFELTNPSDKSGLGWIKLSVLLFSIFGVGVHLMGLL ----------FI-------------------------DRNYWPTLMYCRN--------QLF----ALSFVLA CVQILDFLS----------------------------------------------FHHLFGP--WAIIIGNL MK-DLARFLAVLAIFVFGF--SMQFVAL-------------------------------------------- --NQP-------------------------------------------FKN-GEL-------NPRRGKYFVD E------QEALAEWIEPLPEESPTWRASLRKKRPPPMVMNPLLAFELLFFAVFGMTTYDELTAKDRSDPKRL --LRPAWTDNLFK------------------VVFGIYMLVS--------VVVLINLLIA-----MMS----- -----DTYQRIQVI------IRFQKNPIRAFELL--FFAVF------------------GQTN--------- ------TDA-LKIDTY-NTA----------------TKNNNQ---PTWTEVLFKIVFGVYMLVSVVVLINLL IAMMTDTYQRIQAQS-------------------------------------DIEWKF-------------- ------GL-----------------------------------SKLI----------RSMHR---------- --TT-----------------------------------------------------------TAP------ --------------------------SPINL----------------------------------------- -----------------ITTWL-FYLVNI------CKKRVN-------------------ESVKARK----- -------------------------------RQSLVHL-----------MGSFQRPQQLSPR---------- --------------------------------SKAGAKWLSK--VKK------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------GSQ----------------------------------- ------------------------------------------------------------------VAPK-- ---------------------ESVAL-----------------SV--------------------AHLSP-- ---------------------------------------------LGSQLSFT------------AHTTRIE HVTD------------------------WEAI---------------------------------------- ---------AKKYRALMGE----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------VDEV------------------------------------------------ ---------------------------------------------------------------------KEQ NAD--------------------------------------------------------------------- ---------------------------EENES--D------------------------------------E ---------------D-AVQASNS------------------------------------------------ -------------VQPVT------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >TcPain/1-912 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------MGGRSKKM----------------- -----------------------------------------------DLVRTNSI----------------- ------------------------------------------------------------------------ ---------------------------------------------------------------CPPPE---- ------------------------------------------------TV---------------------- --------------------------------LLES-VKK-----------------NDT-E-------SMK TVIKAN------------------------------------PSILQ------------------------- ------------------------------------------------H-------------LYPY------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------TS-Q--------------------------------------------------------- TILSL---------------------ACSEPGV---APDTVNQLIE--------------------LG-AD- ---------IE--G----TPQ--------------------------------------------------- -----------------------------------WKPL--HLSADNPNILILEVVIK-------------- --------------------------------------------HLKPGQINE-KW-----------N-GNT ALHTLIKG-E-------------------------------------------------------KI-K--- -KDEEN----FC-RHVELLLQ-----------------------------SGI------DV----------- -----------------------------NQ-G-----DGKNL-------TAIFWAAK-------------- ---------YGYKKIV--------KVILEE-SVLHVDLDTC-----------SLRDKTARDLINEKGLY-EG PL----------PERIL-------YQVPKDKIFGLIKEGKEDEFISYFETLSLNNPSD-------------- --FVNADDGASTLL--------QYSCE---------RGLAKVVE---------------------------- ------YLL---------DKGANVNLV--------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --TKNQRKPI--------------------------DIVADI----G------------------------Y FEIFE--------------------------------LLFKC----PDLELSIDT-------LCN------- ---L-------------------------LKHSNS--PKFGKI----------------NHEKC-CKLLLDK LGN------------------------------------RRPPIDINEVDH-L------------------- --------------------------NNI------------------------------------------- --------------------------------------------------------------------PLHY SLR------------------YCDT---------TTTQKLLQLGASLAY-KNE------------------- -FGSMPIQDIK------------------------------------------------------------- -----------------------------------------PEVLENHLDNCVTFDL--------KNAEKRD FEVVFDYQT--------------------------------------------------------------- LLPPRKR------------------KRFKYEEVDPEFLATNNVK-------PETEVIAYMSKAP-E----FR ALLKHPLIV-----------SFLFMK--------------------------------------WH------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------Q------------------- ----------------IRLL-----------------FYTNLVFYICFVLSLVVYI-------------FTH YA------------------------------------------------NFDRT----------------- -Q-SDYCL--IFGKFSWFTL-------N--LTF-------------WV------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------LV-----L---------REVF-QV--AV----------------------- APRKYF-C----------NFENLVEIIL----------------------IVVTGMILYIDSP--------- -------------------------------TS-------------HTRR--------QLA----SVAILLA AFELVLMVG----------------------------------------------QHPKLST--NVVMLKTV SV-NFFKLLLWYSLLIIAF--ALSFYILF----------------------AKT----EMAQSVN--GTETG DEDDV-------------------------------------------FKG-P------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------GKS----- ---------------------LFKTIVMLTGEFD--AGSINFH----------------------------- ----------------------------------------TY---PVTSK----IIFSLFVFMITIILLNLL NGLAVSDTQTIKNDAELVGHISRAQHI------------------------YYVESMLLG------------ ---NILPTSF-------IQAVQRLFCCCPC-------DSDTTYTFF-----------KPLSR---------- --KVCLFTQ--------------------------------------------------N-CQLTV------ --------------------------LPNEYGKISC------ELNSSAKKR----PDPL------------- ------VTCTRNCSEAYLDKNT-IRRIAD---------------------------------IVKAR----- ------------------------------------------------------------------------ -------------------------------------REREE--YPT------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------VTNLKQ---------------------------------- ------------------------------------------------------------------LYGE-- -----------------IVSIKAKLD-----------------QI--------------------------- ------------------------------------------LGSLSTNQNA-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------L--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >TcPkd2/1-705 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------M-------------------- -------------------------------------------------AD--------------------- ----------RKPKTDS------------------------------------------------------- ------------------------------------------------------------------PE---- ------------------------------------------------------------------------ ------------------AVIRPNPD---------------------------------------------- ---------------------------------------IKKGENKEQEKTEGKDEKP--------DKAKGK GEPK-------------------------------------------------------------------- -----TETKET------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------RVR---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------WLTRAMAEDFTRHDVLF--TT-------FRE AV-----------------------------------------LYIIFVIAVTICT-----------V-GRR SASMFY------------------------------------------------------------------ --ITQAL------K--GQFL-E------------------------------------KDF----------- -----------------------------QT-ANE--------------KDIKYYD---------------- -----------IRSAT-------------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------DFWHYTQ---------------------------- ------SLML------ENFYWEHYY----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------NPY-------------------------NPVAKAK----D------------------------D DKKI---------------------------------LFENK-L--LGVPRIRQV----------------- ------------------------------------------KV------KNDSCIIH---EYF-RRLFTSC ---------------------------------------------YDLYGP--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------TDEDRAPFG--LE--AGTAWTYNTAEKTESIPF--------------- SGKISKY----------------------------------------------------------------- ---------------------------------------GGGG---------FYLDLST-NNED-T-----A KLIR----------------DLKENL--------------------------------------WI------ ----------------T-----RGTRAIFIDFSIYNA-NLNLFCVCKL--IFEFPP---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------TGGII--------PSHSFHAVHLVHYVNSWDYVTFVFECT----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------VYAIAGFF-------LAEEIR-EI--IYF---------------------- KLR-YF-L----------QFWTYIDVVI-------------------IGMAFANLITSIVVFPNVDDAILKI QKNP----------------------------Q-------------KYGNLEYLAEMRIFYNNFAASLLFFS YIKLFKYLN----------------------------------------------FNKTMGQ--LNNTLKRC AF-DILGFSIMFFIIFFAF--AL-LGYLLF--------------------------G--------------- -------------------------------------------SQVEDFSS-F------------------- --------------------------------------------GV-------------------------- ------------------------------------------------------------------A----- ---------------------MFTLLRTILG-------DFD------------------------------- ---------------YQAI--------------------EKAN--RVLAP----IYFLAYIFFVFFVLLNMF LAIINDTYADVK----TEIAIAPDEMQ------------------------MTEFLK--------------- -------------------------------------------KGFYK---------------------MLQ KCGC----------------NIKY---------FQQQKA-------------EFNA----TIQQIRDALKKC GFS----------------------DLEIEMFFAR------------------------------------- ------------YNIDPLAEVG-DYDIKKIMKELEGQSMA--------------------------KEKVDE D---------------------------------------TT------LV-HVSDFITQQERLD-------- -------------------------QI------------EKT--IQ---------------MLATKIDT--- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------LIKK----------- ---------------------------------------------------------------LEALENVR- --------------------KAKA----------------TQG----------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >TcPyr/1-887 ------------------------------------------------------------------------ --MS-------------------------------------------------------------------- ------------------------------------------------------------------------ --LRHERPGKTIE----------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------ESTV-------- -------------------------------------------RWNGDIS---------------------L DMTDE------------MG----------------------------------------------------- --SIS--SE-DETGSE-------------------------------------------------------- ---------------------------------------------YDGEQR--------------------- ---------------------------------------------------SRG------------------ ----------KSVL---------------------------------------------------------- ------------------------------------------------------------------------ -EIWDDDYI--------------------------------------------------------------- -----------QAR----LQASILP--------------------------------DAE-D--------II EMIEQ-----------------------------------------DNTETIFT-K-NPTSL---------- -----------------------------------------------LLIATWLQKEKVLQEVLEK-GVSL- ---QAVD-G--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------EGR--------------------------------------------------------- SALHL---------------------AACTG-----NIDCIKLLLQ--------------------HG-AE- ---------ISARDA---LNR--------------------------------------------------- -----------------------------------ATPL--HCAASKGHLSAVKLLIR-------------- --------------------------------------------HGA--DVNAGLD-------------NKS PLHYAVQSLA-------------------------------------------------------------- ------I------DCVKELLE-----------------------------NNA------IP----------- -----------------------------NT-S-----QVYSE-------TPLHVAAA-------------- ---------LGAPEIV--------KLLLDH-GAA-VNVQC-------------------------------- ------------------------------------------------------------------------ ------GTDKLTPL--------HLAAE---------DSDAESAR---------------------------- ------LLI---------DAGAQLTSEN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---HKKQTPL--------------------------HLAALS----Q------------------------C SETLE--------------------------------LLLAR-G--CNPN-ARDA-------DGR------- --------------------------------------TPLHGAIVK----------VSRSCEC-VRLLLKA GAD------------------------------------------VNRQDS-F------------------- --------------------------GYT------------------------------------------- --------------------------------------------------------------------PLHL AA------------------LNEFS---------NCVMMLLNHGGDVTV-RTN------------------- -GGVSVLSFI-------------------------------------------------------------- -------------------------------TR--KTP-DVIPRYISKFDSSIKINDH--------EIGDVD CELKLDFRI--------------------------------------------------------------- LVPT--------------------------------------------MGHQETELLLNFIEVG-H-----R EVLKHPLCE-----------TFLFLK--------------------------------------WR------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------R------------------- ----------------IRKF-----------------FLFSLFYHSLFVLLFSIYT-------------IGV Y-------------------------------------------------IQDC------------------ ----------------------------------------------------PSF----------------- ------------------------------------------------------------------------ -------RALLTRPCRVPQ----------------------------------YYN---------------- --------------IIGYILLVFNFMFLA---------KELF-QI--CH----------------------- SWRSYI-Q----------QWENWLQW-L----------------------IIISVFCCV------------- ------------QP-----------------SL-DNDMDIRYKVM-RWQH--------HVA----AVGIFLA WVELMMIVG----------------------------------------------RFPIFGL--YIQMFTTV AV-NFIKFVIAYFCLLLAF--AFSFGVLF----------------------AK------------------- --YKS-------------------------------------------FKL-L------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------KWI----- ---------------------IIKVLVMMSGELE--YEDIFYD----------------------------- -------E---EAPIQ-------------------------Y---DYTSQ----FVFLAYVILVTIILANLL VGLAVSDIQGLQQSAGLDRLVRQAELV------------------------AHLESMLFSRLLTCI------ ------P------------------------------------HKLM----------HFFHK---------- --KA-LLL----------------------------KSQYHWA--------------------LYI------ --------------------------KPNDPREER------------------------------------- -----------------IPKDL-IKNI--------YQL-------------------------VAER-KEKP ---------------------------------------------------------RKKRRS---NKIKSD FVSP---------------------PM----------SRLNS--ISD------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------SY--------------------GGADK---------- ---------------------------------------------------------------QVALKCE-- ------------------------LE-----------------EI--------------------------- ------------------------------------------QKEFAEFTR--------------------- ------------------------------------------------------------------------ -----------TFREKMEG----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------I--------------------------------------------------- ----------------------------------------------------------------------TN QIK--------------------------------------------------------------------- ---------------------------NTKS----------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >TcTRPA1/1-1317 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --MDKKRYGV-------HNDL------------------------LQS------------------------ ----------------------------LKDF-QISLRRTT------------------------------- -------------------------------------------------------------MPFV------- --------------------------------------------TLANVSIN----------SGEALRLNIQ AEGGRISIP-----EFPLGPRGLQR-------FRPPRQTLIEIGTTKTARSWRIDTEDPQR---LSPS---- TPIITVLPSVEVPEKTTIYPDEVKCETSQDRTRRDTLNWLMSS------------LRSILPSSGHKSASGSP SELQNMLPSSVKVHRLSNAGKPPEDNGGICLMTESPFRILRVAECGNLE-TFQRL----------------- -------------------------YFADPTRLS-----------IK-DSRGRTA----------------- --------AHQAAA---------KNRITILQFILSQGG---------------------------------- ----DLNNQDNA---------------------------------------------------GNTPLHVAV ------------------------------------------EHESLD------------------------ -----AVDFLLQAG----VKTNILNDKKQAA-IHLV-TEL-----------------NKV-S--------VL EVMGKHKDKI--------------------------------DILQGGEHG--------------------- --------------------------------------------RTALHIAAIYDHEECARILISV--FDA- ---CPRRP---------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------CN----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------NGY--------------------------------------------------------- YPIHE---------------------AAKNA-----SSKTLEIFLQ--------------------WG-ESR GC--TREEMISFYDS---EGNVPL---------HSAVHGGDIKAVE-------------------------- -----------LCLRSGAKISTQQHDL--------STPV--HLACAQGATDIVKLMFK-------------- ------MQPEEKLPCLASCDVQK-----------------------------------------------MT PLHCAAMFDH-------------------------------------------------------------- ------P------EIVEFLIN-----------------------------EGA------DI----------- -----------------------------NP-M-----DKEKR-------SPLLLAAL-------------- ---------RGGWRTV--------HVLIRL-GAD-INVKDVNRRNVLHLVVMNGG--RLEQFAS-------- ---------------------------------EVSKAKSQTSLLQLLN----------------------- ----EKDINGCSPL--------HYASR---------EGHIRSLE---------------------------- ------NLI---------RLGATINLKNNNNESP-------------------------------------- ------------------------------------------------------------------------ --------------------------------LHFAARYGRYNTVRQLLDS-------------EKGTFIIN ESDGEGLTPL--------------------------HIASKQ----G------------------------H TRVVQ--------------------------------LLLNR-G--ALL--HRDH-------NGR------- --------------------------------------NPLHLAA------------MNGYTQT-IELLLSV HSH-----------------------------------------LLDQTDK-D------------------- --------------------------GNT------------------------------------------- --------------------------------------------------------------------ALHL ATM------------------ENKP---------NAIALLLSMNCKLLY--NQ------------------- -MEMSAIDYA---IYYK---------------------------------------FPEAALAMVTHEDRAE --------EVMALKSSKHP------YVTLALIA--SM----PRVFEAVQDKCITKANC--------KKDSKS FYIKYNFSA------------LQCSQF-YADMDHKTGDALAISKPIPLPAL--------------------- ---------------------------------------------------------NAMVSHG-R-----V ELLAHPLSQ-----------KYLQMK--------------------------------------WN------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------S------------------- ---------------YGKYF-----------------HLTNVLFYSIFLTFVTCFA-------------YEI M----------------------------------------------------------------------- -----------------RHE-------D-------------------------------------------- ------------------------------------------------------------------------ -QI-ITYNATNLTHDE--YVNFSKA---------------------------NILNVKIT------------ ----------PMMYMSALAIITYIILNTI---------REMV-QV--YQ----------------------- QKFMYF-L----------DPNNLVTWVL----------------------YTCAVVMVFPIFW--------- ------------------------------------------GTMYELQF--------SCA----SVTVFLS WFNLLLLLQ----------------------------------------------RFDQVGI--YVVMFLEI LQ-TLIKVLLVFSILIIAF--GLAFYILL----------------------SR------------------- GDHLS-------------------------------------------FKT-I------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------PMS----- ---------------------LVRTFSMMLGEID--FLGTYVKPYYL--------------TT--------- ------EDE-KS-F-L------------------------PF---PLPAF----FILGLFMVLMPILLMNLL IGLAVGDIESVRRNAQLKRLAMQVVLH------------------------TELERKL-------------- ------P------------------------------------KMLL----------ERVDK---------- --CE-----------------------------------------------------------LIE------ --------------------------YPNDTKCK-------------------------------------- ------------------LGFF-DSILRK------W-FGNP------------------------------- ----------------------------------------------------FSDE-GLD------------ -------------------------------------MAMEG--VED------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------YVVNE----------------------------------- ------------------------------------------------------------------LDKT-- ---------------------KRKLK-----------------EI--------------------TTA---- ---------------------------------------------LETQQQF-------------------- ------------------------------------------------------------------------ ------------LRLIVQK----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------MEIK------------------------------------------------ --------------------------------------------------------------------TEAD DVD--------------------------------------------------------------------- ---------------------------EGVSP--NDLKPITGH-----------------------A----S ---------------K-WTSPKIR------------------------------------------------ -------------KKLRS--VVSFNNK--------------------------------------------- ----------------------------------------------------GSST---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >TcTRPA5/1-580 ------------------------------------------------------------------------ --MS-------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -SSIS------------------------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------------------PLHRAV----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------TS-------------------------- ---------------------------------------------------------GDV-S--------LV KRL--------------------------------------------------------------------- -------------------------------------------------LAA---------------GSDP- ---NAAD-S--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------HGR--------------------------------------------------------- TPIVF---------------------A--------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------EC---------- -----IKNDE-------------------------------------------------------L------ -----FE------QIVELLIA-----------------------------HGA------DV----------- -----------------------------NA-C-----ND-------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------TPL--------YSAVF---------YGKKHLVE---------------------------- ------RLL---------KAGA------G------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---VRSNNLL--------------------------HIVAEK----G------------------------D DTILA--------------------------------LLLGD-K---------------------------- --------------------------------------------------------RSEEMIDG-------- ------------------------------------------------EDA-N------------------- --------------------------GRT------------------------------------------- --------------------------------------------------------------------SAFL AA------------------QHDHK---------RCLKMLIAKGADLSR-ADL------------------- -QGESVMEAI-------------------------------------------------------------- -------------------------------FE--NMT-KPVEFLTEVLDASVTLER------------GEK NKYFV------------------------------------------------------------------- -----------------------------------------------------------ASEEE-K-----T SVLQHPVIE-----------LYLSIK--------------------------------------WS------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------R------------------- ----------------MCYF-----------------FYLWIFAYVLFVLSFSVYV-------------MLC R-------------------------------------------------DYRNL----------------- -DV--------------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------LVT---------------- --------------ASRWISIWSGACLLG---------HGVL-EC--CL----------------------- THGNHF-R----------KYEMWLNLAC----------------------TSLSLIVAIAGKR--------- --------------------------------D-GNREDELA-AP-NWVL--------HVT----SIAILLS WTELMLLIG----------------------------------------------RLPTYGY--YALMFSAV LQ-NVIRVLLAFLCLVVGF--SLSFSIEF----------------------AN------------------- --CSE-------------------------------------------FND-P------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------WRA----- ---------------------LVKTTVMMMGEFD--YSDLF------------------------------- -------------TGL-------------------------E---RPASR----VIFLLFVILTSIVLMNLM VGLAVSDIQCLQMVSHARKLEKMADFL------------------------AQLEKVLTSEKFKKRWL---- ------P------------------------------------QIVQ----------KILR----------- ----------------------------------------RNF--------------------IDV------ --------------------------RYELETSARFRRSK-KLS--------SKLIGS-------------- ------------WCNVIIEHRL-RRRTCS---RLPYIL-------------------------IPSS----- ------------------------------------------------------------------------ ----------------SP-------RG--------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------PSRIINPNR--------------------- ------GPS--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------------PK Q----------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >TcTRPM/1-1593 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------MNEP--------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---CGCGRT-LAQHKHN-TETVPPLA---------------------------------------------- --GEIWFPSRCT---------------------------------------------------TALPTDAYG ILEFQGGPHP--------------------------------SKAQYIR----------------------- ------------------VAHDTKPEHLMQL-ITKE--------WNLELPKLLISIQGGK-A-----NFELQ PKLKK---------------------------------VLRKGLLKAARST--------------------- -----------------------------------GAWIFTGGTNTGV---------------TKHIGDAL- ---LLERSQ--------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------RTG---------------- ------------------------------------------------------------------------ ----------------------RVNTLGI------------------------------------------- ----------------------------------------APWG---------------------------- --------IVENNQEL-------------IG-----HN---------------------------------- TEVPY----HSIS--------------SPRSKFAALNNRHAYFLLVDNG-------------TVGKYG-AE- ---------IVLRRRL--EK-------------YISKQRLYPFTQS-------------------------- -----------------------------------PIPI--VCLVIEGGTNTIRAVLE--YVTDDP------ -----------------------------------------------PVPIVVCDG-----------S-GRA ADLIAFMCKY----------ELSVLKSMRDYIIATITRAFEVNRELAEC-------------LYGELMQ--- --CVENK------NLITVFRIADK------------------------YDQKP-----QEL----------- -----------------------------DQ-T-I--------------LTALFKSQH-------------- ---------LSPTE----------QLSL-------------------------------------------- ------------------------------------------------------------------------ ------------AL------------------------TWNRAD---------------------------- ------IA------------RSEIFIYGQEWP---------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------RGAL----------------------EEAMMKALEH----D------------------------R CDFVK--------------------------------LLLEN-G--VSMRKFLTI--------PRL------ --------------------------------------ENLYNS-------------KEGPSNI-LRYILRD --------------------VRP-HIPAGYVYTLHDIGLVINKLMGGAYRAFYT-----------RRKFRPI YAKVMNKGQ------------NMQRNSTS----------------------FVKQYGN-------------- --AMSLL-----------------------------------AQALPSNANPCL----------FD-YPFNE LLIWAV--------------LMKRH---------KMALLMWQHGEEALA----------------------- -KALVGCKLYKAMAHEAAED---------------------------------------------------- ----------------------DMETEVYEELR--SYGKEFENIALEVLDFCYRQDDD-------------Q TQQLLTCELQ-------------------------------------------------------------- -------------------------------------------------NWSGQTCLSLAVAAN-H-----R ALLAHPCSQ-----------IILADL--------------------------------------WM------ ----------------GGLR--TRKNTNLKIM------LGLLCPPYIL--KLEFK----------------- -SKEELQLMPQTTEEHM---------------------------ELENDDDD-------------------- ---K-SDSD-----------------------------KNVDGEVSVM------------------------ ---------------------------------LSDPEENKYHVFFTDV--------------PQERVPRNR ELKIS-----------KKLY--------EFYTAPITKFWANSIAYITFLIIFSYTI-------------LVK MDE--------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------RPSWQEWLAISFMCTYGC---------EKLR-EL--FSS----EPV-----------GLKQ KLAVWC-W----------NLWNPCDMAA-------------------VLFFLIGVVLRFK------------ -------------------------------------------------EST-FEVGRVFY----CVNSIYW YLHILNILS----------------------------------------------VNKYLGP--LVTMMGKM VK-NMIYFVVLLLIVLMSF--GVSRQAILFPD-------------------TP------------------- -------------------------------------------PSWGIARD--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------V----- ---------------------FLEPYFMLYGEVY--ADKID---------------PPCGE----------- -------D-EEKP-CQTGR---------------------------WVSP----VIMSVYLLVANILLINLL IAVFNNIFNEVNAVAHQVWMFQRFTVV------------------------MEYEQK--------------- ---PILP-------PP--------------------FIIFCHIYLLIK----------YLRR---------- --KM----------------EGKE---------ESYDNGLKLFLDR------DEMERLYDFEEDCVEGYFA- -------------------------EQELKLQQST------------------------------------- ------------EERIKVTTER-IEHLTQKIEDINTKENIHTT----------------ALQNLELRCRRLV DQMQEVSTEMEKIRTSIESQGSTAG--------------------------PSFDAGFIRERTVSEPTE--- --------------------------A------------LVE--DVPT--LKIGSSATKRKPIVRSLTE--- --VRPDAYI-----FDNGQ------------------H------IEYRYDEEE-------ECNEEI------ ----------------------------------------DPLP--------------------KSESQQP- ---------------------------------LTFERQRTRS-------------T-DSK-------TS-- -----------NDSAEVSADDL-------------GALSL---------EVLRNWAI--------QKRKDST ---------------GTG-R-----------------RSSDGGNGE------------------------DS SNG--------------------------------------SKRSLNK------------------------ ------------------------------------------------------------------------ -------------RQLSQT-HSEPE--TSDPPA--------------------------------------- ---------TATNP-SH------PM-TLERSV-T-FT-----------------EPRIK------------- ------------------------------------------------------------------------ ----------------------------------VIPPTSI--AGGSNR----------TALLMH------- -------------MHTEYTSITDE---------------------------------------------LES VC-GLLSPPRSP------------GLLSPPRPEQSPPSQRKRHPSEMSNP------EIAINFEK----EHLR SAEECDYMVMENLIQRRY----------------------DEEDGEH----------GPLN--------PDL LSVVTE----TREFRISSIGSRP---LKRA-----SAVE-----------------------------GDAQ ---------------P-LGITV--SCKAVAV----------------------------------------- -----------TNFADSGSDSAIQGDSTERQDSTE------------------------------------- --------------------------------------------------SNDITSALL------------- ---------------------------------------------NQPPMPQRPSIVMDSS----------- ------------------------------------------------------------------------ ----------QLPIQ---------------------------REVQKAE-SKDSLHMQSETMC--------- >TcTRPML/1-598 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------MEPMQ------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------GNSPESV-- ------------------------------------------------------------------------ --------------------------------TTCG---------------------TDD-E---------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------RCCLTHQPSCHSS------------------------- -----------------------------------KSLL---------TEEKMRRKLQ-------------- ---FF--------------------------------------------FMNPIEKWQ---------AKKRF PYKFTV------------------------------------------------------------------ -------------QLIKIILV--------------------------------------------------- --------------------------------T-M---------------QLCLFAYNR------------- ---------YNHVNYTWDNRISFSHLFLRGWDAT-------------------------------------- ------------RE---------------------------------------------------------- -VSAYPPATGPLAI-------------------YKADDFYATID---------------------------- ------YAYSGYANLSQ-AVGSYSY----------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ANEDNTMTDMELCLSQYKKG----------------IIFGFN----E---------------SYVFD----A -EIVDTC--------LNIT------HRQDHLLDSKQ-YL--D-N--LNI----NF----------------- --------------------------------------SALVKAV--------------------LKFSVKT VNFKT-------------------------------------AGRISPPNC--------------------- ------------------------------------------------------------------------ -------------------------------------------------------------------YRFDI NIN-----------------FDNED----------------------------------------------- HDGQMLLWLD-------------------------------------------------------------- -------------------------------------------AQPVRLM-CKGDVEYVT-----DDEIDSL LQSLLNYLVI-------------------------------------------------------------- -------------------TICIL-----------------------------------------SFVLCTR ALLRAQKLKKMTN-------SFFINQFGRPLSKEDRNKFLNL----------------------WY------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------VMIIINDILIII---G-----SSIKEQI--------------------------- ERKDFT-S----------DQWNVCSLFL-------------------------------------------- -----------------------------------------------------------------GLGNMLV WFGVLRYLT----------------------------------------------FFKTYNV--VILTLEKA AP-QVARFLLCALLIYAGF--TFSGWLILGPYH--------------------------------------- --------------------------LK--------------------FRS-L------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------STT----- ---------------------SECLFSLINGDDM--FATFSIMSS-K------------------------- ---------------------------------------STML--WWFSK----IYLYSFISLYIYIILSLF ISVIMDAYDTIK---------------------------------------IYYIEGF-------------- ------P---------------------------------------------KSDLQIFI------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------GDTNFEDVSS------------------------------------------- ------------------------------------------------------------------------ -------------------------GI-----------------FRTAS----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------NDS----------------------- ------------------------------------------------------------------------ ------------LGGLMKD----------------------------------------------------- ------------------------------------------------------------------------ ------------LCCCTCT----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------K----- -LQ--------------------------------------------------------------------- ------------------------------------------------------------------------ ---------------K-------------------------------------------------------- ------------------------------------------------------------------------ -------------------------------------------------SYSSLSRGSL------------- --------------------------------------------------ATEGSRRGSNAV---------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ >TcWtrw/1-967 ------------------------------------------------------------------------ --MD-------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------NMGFQD-S------------------------------- ------------------------------------------------------------TNSR-------- -------------------------------------------KLGR------------------------- ------------------------------------------------------------------------ --SVSVNAEVE------------------------------------------------------------- -----------------------------------SFPL--------------------------------- ------------------------------------------------YKTHTC------------------ -----------PSG--------------------LRW----------------------------------- --RRPRDDPE-IVVEEEFPS-DD---------------------------------FEYMEC-GPSPPADHT PNIY----------------------------------------ESFEEF---------------------- ------SRSELTVQ----ICHDTIKMNLLEH-MKMA-S-------------------GRH-Q--------LL DDIEC------------------------------------KKTTQDTLTEAFQ-G--ATKL---------- ------------------------------------------EINIAFLWAAFMKRWELLDGLLKL-GAQL- ---RYYEPS--------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------QGL--------------------------------------------------------- SALHL---------------------ASFSG-----CIPGTQFLLA--------------------QG-CD- ---------VNA--I---FKC--------------------------------------------------- -----------------------------------YTPL--HCSAFGDSPETAMILLN-------------- --------------------------------------------NGA--KVQALTNSPN-NCH-------ES VLHCAVRANA-------------------------------------------------------------- ------I------ACVRLFTA-----------------------------EGA------DV----------- -----------------------------GQ-F-----EFSGM-------SPVHLAAD-------------- ---------LGHPQCL--------KIMLEAKGVN-VNAKT-------------------------------- ------------------------------------------------------------------------ ------KEKELTPL--------HLAAE---------GGYVECVE---------------------------- ------ILL---------DKGADANIRN-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---HRGQTPL--------------------------HLAARA----Q------------------------A YDCVE--------------------------------MLLRK-GN-ADPN-IGDF-------DKR------- --------------------------------------TPLHAAVCK----------AARSYDI-IEILVSW GAD------------------------------------------VNTKDQ-Y------------------- --------------------------GYT------------------------------------------- --------------------------------------------------------------------PLHI AA------------------LNELS---------QCVEILIYHGADVTA-KSK------------------- -FGMTALGII-------------------------------------------------------------- -------------------------------TR--KTP-ASLAMVTHKLDSAITLHHHP-------ESSNRE VELRLDFRS--------------------------------------------------------------- ILQH--------------------------------------------CHPREISFLNTFVDEG-Q-----K EILLHPLCS-----------AFLYLK--------------------------------------WE------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------K------------------- ----------------IRKY-----------------YIARMLFCFIFVLSLSLYV-------------LTA L-------------------------------------------------AHNCY----------------- -NH-----------GKNMND-------T---QP---QNV-------------IELC---------------- ------------------------------------------------------------------------ ----EKKSMMGHMLRTNPF----------------------------------VIE---------------- --------------MQWFVLVGITCCEIL---------RKVY-GIAGYP----------------------- TVKQYL-S----------HPENIIEW-T----------------------VVVSVFVISF------------ ----------IYTG-----------------R-----------TY-TWQN--------HIG----AFAVLFG WTNLMLMIG----------------------------------------------QLPVFGS--YVAMYTRV QG-EFAKLLLAYSCLLIGF--TISFCVIF----------------------PD------------------- --SST-------------------------------------------FAN-P------------------- ------------------------------------------------------------------------ ----------------------------------------------------------------FIG----- ---------------------LITVLVMMTGELN--LDLLVDD-DPE------------------------- -------D----PPFL-------------------------L---EISAQ----VTYILFLLFVTVILMNLL VGIAVHDIQGLQKTAGLSKLVRQTKLI------------------------SYMELALFNGYL--------- ------P------------------------------------RYLL----------NLLHW---------- --TA-LVS----------------------------PKAYRVV--------------------LNV------ --------------------------KPLNPREKR------------------------------------- -----------------LPRDI-LKAA--------HEI-------------------------AKKR-K--- ----------------------------------HYAH-------------TISSHGSNA---TTRKIINNN MDQNSEIL-----------------EY-------P--SAFPL--LQS------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------KIE--------------------KSTEQ---------- ---------------------------------------------------------------IEHLSKE-- ------------------------VR-----------------EL--------------------------- ------------------------------------------KIALQNNQK--------------------- ------------------------------------------------------------------------ -----------IMEQLLHG----------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------LVNTK----------------------------------------------- ------------------------------------------------------------------------ NSS--------------------------------------------------------------------- ---------------------------NC------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >TcXP_968598/1-1213 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------MGDSVDV-EA---------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------KVT------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------RKT---------------- ------------------------------------------------------------------------ ---------------------LIMPNLP-------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------KSLSIE--EK---------------------------------------------------- -------------------------------------KY--LLAIERGDMANVRRMLQ--KAHR-------- ---------------------------------------------KKSFDINCVDS-----------L-GRG ALSIAI------------------------------------------------------------------ --DQEHL------EMVELLV-I------------------------------------MGV----------- -----------------------------ET-R-----------------DALLHAIH-------------- ---------VEFVEAV--------ELLLEH------------------------------------------ ------------EE---------------------------------------------------------- ------------LI--------HKDGEPY---------SWQKVD---------------------------- ------I-------------NTAMFTPDI------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------TPL--------------------------TLAAHR----N------------------------N YEILK--------------------------------ILLDR-G--ATIPMPHDI----------------- ------------------------------------------KC------GCDECIKE-SEEDY-LRHSLAR ---------------------------------------------LNEYKALAS------------------ ------------------------------------------------------------------------ PSLIALSSS----------------------------------------------------------DPI-- ------------------------------------------------------------------------ ---LTAFQLSWELRNLAF------------------------------------------------------ -----------------------AEPECKSEYM--DLRRQCQQFAVDLLHQTRSSQE--------------- LAFILNH-----------------------------------------D----------------------- --PAA-PP-------------------------------YEEG------EHMKLARLELAIQYK-Q-----K KFVAHPNIQ-----------QLLAAI--------------------------------------WY------ ----------------EGVPGFRRKSSTQKIMIIVK--VAVLFPFYCM--LYMITP---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------GTKTG--------KLMRKPFMKFLIHASSYLFFLFLLILVS--------------QR AEDQII--------------------------------------------EL--F----------------- ---------------------------G-------------------------------------------- ------------------------------------------------------------------------ ------TESMKQNLQEKYR----------------------------------------------------- ------KQRGNPPTILEYVVLIYVIGFIF---------EETH-EI--YVE---------------------- GMKSYL-R----------NLWNFIDFTR-------------------NFLYTAVFLLRVAAYIQQTSEIEND PFTA-------YIR-----------------RE-------------EWQAFDPQLIAEGLF----AAANIFS ALKLVHLFS----------------------------------------------INPHLGP--LQISLGRM VI-DIVKFFFIYTLVLFAF--ACGLNQLLWYFSDLEKKKCYHLP--------------SGEADFD------- NAADS------------------------------------C-MKWRRFAN-V------------------- --------------------------------------------FE-------------------------- ------------------------------------------------------------------S----- ---------------------SQSLFWASFGMVD--LASFE------------------------------- ---------------LTGI--------------------KTYT--RFWGL----LMFGSYSVINVIVLLNLL IAMMSNSYAMIDEHSDTEWKFARTKLW------------------------MSYFEE--------------- --SATLP-------SP--------------------FNIFPKPKHLF----------------------KLL GLRK----------------KDKI-----------RKMSTKRRN--------REEKERDYKYTAVMRALVW- --------------------------RYVSAMHRK------------------------------------- ------------LEENAVTEDD-VNELKSDISSFRYELLEVL------------------------QKNGMD ISSAEM-----------------------------KEKA------------VLGRKMKVWER---------- -------------------------RL------------MKD--FK-----------------VAPVVT--- -------------------------------------------EEEEEFIYQP------------------- ----------------------------------------P-------------------------PE---- ----------------------------------GENSLAKFR--------------RIAR----------- ---------------------------------------------------------------LAVVNSNLS ----------------------------------------KWRQV-----------------------VKGA C-IA--SQI---GH---------------------------CHSRDSFKKQQN------------------- ------------------------------------------------------------------------ -----------LQRAMEEARKLKVK--SPD-QS--------------------------------------- ---------RATTP---------IQ-LPDT------TGSNIIKIIR------GITPE--------------- ------------------------------------------------------------------------ -----------------------TVDT-KY--CL-TPRD--------------------KSPLISIS----- ---PPK-------------------------TPEKEPDLINL----------------------------ES AKTS----PVLPVK------------AMP------SDDVSLESVDKIINDSNSLDDDKVRSLPT----SPTS SD-----D---------------------KSLDSLSKKA--------------------------------- --------------------------LFSSGS--FT-P--------------------------EEN----- ---------------E-KKEEE-TEPKNVTF-------S------------------------------FDF I----------DESSKGESSAEILKKSEEET----EE-NLD------------------------------- --------------------------------------------------KSDEPEPS-------------- ----------------------------------------------LEETKEESEEVHDLPEETVQAKS--- ------------EDEV-----EETENNEIEEPQADLEESEPQL--DEK-EEESQVKSEELTVEEKEIQVEVE KVCAKSVDELEAPEKKEEV-EEKI---------------EKEKSPLAVRNIQRIGDRGRRQPKTGWL----- >TcXP_968670/1-855 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------M-------------------- -------------------------------------------------FG--------------------- ----------SD-------CN--------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------NERAL------------------------------------------------------------- ------------------------------------------------------------------------ -----------------------------------------------------SQ----------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------V--EK---------------------------------------------------- -------------------------------------SF--LLHAERGDCATVRRIIE--EYGGG------- -------------------------------------------EGDQEFDINCIDA-----------L-NRS AFVIAI------------------------------------------------------------------ --ENGNI------ELVKLLL-E------------------------------------SQI----------- -----------------------------DV-K-----------------DGLLHAIN-------------- ---------EEFVEAV--------EMLLDW------------------------------------------ ------------EE---------------------------------------------------------- ------------RT--------HQVGDLY---------SWEKVE---------------------------- ------R-------------CSATFTPDI------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------TPL--------------------------VLAGHK----N------------------------N YEIIK--------------------------------LLLDR-G--ATLPLPHDV----------------- ------------------------------------------KC------GCDECVCS-NQSDS-LRHSQAR ---------------------------------------------INSYKALTS------------------ ------------------------------------------------------------------------ PSLISLSST----------------------------------------------------------DPL-- ------------------------------------------------------------------------ ---FTAFELSGDLRRLSR------------------------------------------------------ -----------------------LETEFRAEYN--NMRTVVENFAALLLDHVKTSEE--------------- LMILLNY-----------------------------------------D----------------------- --EKN-PS-------------------------------WVLG------EQQTLGRLKLAIKFK-Q-----K KFVAHPNVQ-----------QILGTI--------------------------------------WY------ ----------------EGLPGFRRKNLFGQTLQLMR--LSAMFTVYCL--VYMLLP---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------TSKMG--------LFIKKPFVKFICHSSSYILFLVLLGVTS--------------QR FEITIL--------------------------------------------EW--V----------------- ---------------------------D-------------------------------------------- ------------------------------------------------------------------------ ------TGWSRDFVDEWKR----------------------------------------------------- ------KERGALLGFAECAVVLYLLKLVFL----GKMCKEIK-HL--WAS---------------------- NLLEYV-S----------DLWNIVDFVT-------------------NLFYVAWLSLRLCSIYLTRASVWSL GEDP-------WFP-----------------RE-------------EWNSFEPMLIAEGAF----AAAMIFS FLKLVHIFS----------------------------------------------VNPHLGP--LQISLSRM II-DIVKFFFIYTLVLFAF--GCGLNQLLWYYAELEKNKCYHRG---------------GMPDFE------- AHDKA------------------------------------C-TIWRRYAN-L------------------- --------------------------------------------FE-------------------------- ------------------------------------------------------------------T----- ---------------------SQSLFWASFGLVD--LLSFE------------------------------- ---------------LTGI--------------------KSFT--RFWAL----LMFGSYSVINIIVLLNML IAMMSNSFQIISERADVEWKFARSKLW------------------------MTYFED--------------- --DDVLP-------PP--------------------FNILPNTELFC----------------------RVF KL-------------------------------RRKKNKICNK---------ESQLRIKAKHDSVVRLLLK- --------------------------RYNTSEQRK------------------------------------- ------------RHEFGVTEDD-VIEIRQDISTLRYEIIDIL------------------------KNNGMR TPNMSF-----------------------------EDKQV-----------V-GKKGKMIER---------- -------------------------RI------------LRD--FH-----------------IGVVDE--- ------------------------------------------------------------VGKSEV------ ------------------------------------------------------------------SY---- ----------------------------------SPNKR--------------------------------- ------------------------------------------------------------------KRRTFR --------------------KEKK----------------DWNSL--------------------------V R-KNTKSYDPI-GS---------------------------SKNHFE------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ >TcXP_970049/1-779 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------MSRDP--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------ENPDAT------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------IPP---- ------------------------------------------------------------------------ ------------------PPPPPMPNFGR------------------------------------------- ------------------------------------------------------------------------ -GPGR------------------------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------MG-----------YRRLE---------EDD---------------------------------- ELLM----------------------PRPS---------------------------------------IL- ---------LPHLQES--EK---------------------------------------------------- -------------------------------------RF--FELVHSGDVAAVNDFLN--ENPG-------- ------------------------------------------------FNINCVNF-----------Q-GVS GLLIAV------------------------------------------------------------------ --QSRSE------AMVEFLLSQ------------------------------------PDI----------- -----------------------------DI-G-----------------DCVLHAIR-------------- ---------DNQPKIL--------ELLLEK------------------------------------------ ------------QR---------------------------------------------------------- ------------NT----------------------APSLEYVG---------------------------- ------V------------THSSDFPDYV------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------TPL--------------------------ILAAQC----G------------------------H YEIIE--------------------------------MLIDR-G--HTISKPHSPS---CRSVPKV------ --------------------------------------RYGHCC------RCMDCKAQLERDDL-LHAEHLR ---------------------------------------------LNLYKSVCN------------------ ------------------------------------------------------------------------ PAYICHSSR----------------------------------------------------------DPI-- ------------------------------------------------------------------------ ---LTSFQLSTELRQCSF------------------------------------------------------ -----------------------LVPEFRNSYL--ELANEVSNFAVELIAGCRNSGE--------------- VETILKQKA--------------------------------------------------------------- --GIQ-NA-----------------------------------------SIFMYPRLVLAMDYK-Q-----K FFVAHAHVQ-----------HIVESL--------------------------------------WR------ ----------------GNWYDYNLK-PIPAKI-IYPIFRILLLPIIVV--MCIFLP---------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------KHQMV--------AHWNIPLNRMINHVAAFLVFLVIIFLESN--------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------RSKEN----------------------------------------------------- ------QKRMPPNSGLEPVIIIFVVANCW---------SVVR-MC--LIQ---------------------- GPRRYF-T----------YLWNWHAVIS-------------------NTFFVLTFVFWLASYVDAVNNDQV- -----------DLE-----------------RK-------------YWHHLDPVLIAEGTF----AVAVIMT YFKLMFFCR----------------------------------------------LNYYLGP--LQISLGKM CS-DMAKYITIFIIIIISF--TAGLCRFYSYYDGMVQVDS-----------NG------------------- -------------------------------------------IKTAQVSS-F------------------- --------------------------------------------ID-------------------------- ----------------------------------------------------FST-----------T----- ---------------------LKTFFWAVFCMAP--LETGD---VI--------IENLPGDTENT------- --------------TIINK--------------------HLFT--EAVGY----IAFALFEVLTVVMILNML IATMSSTFQRVLDNIDVEWTFGKTDFY------------------------LEYMLQ--------------- ---PTLP-------PP--------------------LNLIPTPSGISA-------FMEWF------------ -------------------------------------QSPKVD---------PREEEKRNDYPALMSQLVQ- --------------------------RYFRDKDSA------------------------------------- ------------ASPE----ND-LEFLKQEIAEIK------------------------------------- ------------------------------------------------------------------------ -------------------------QA------------VND--LL-------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------EKE------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------