Data S2 - the list of modules ID group size - the number of microenvironments in this module. cofactors - list of the cofactors that can be found in microenvironments belong to this module. types - the types of cofactors that can be found in microenvironments belong to this module. Degree - the degree (number of connections) of this module on SpAN. betweenesscentrality - the calculated betweeness centrality of this module on SpAN. diversity - the fuctional diversity of this module. ID group size cofactors types Degree betweenesscentrality diversity 85 1261 F3S;SF4 FES 32 3858.863348 29 7 18602 1VU;COA;NAD;NAP;NDP;ADE;SAM;CO;CAA;HMG;PNS;MLC;PLP;FE2;NJP;FAD;CO8 Nuc;Organic;CO;FE 28 2795.500866 371 134 608 HEC;HEM Heme 21 1022.392063 6 130 1087 HEB;HEC;HEM Heme 15 2003.405195 16 136 633 HEC;HEM Heme 14 688.848413 5 537 481 FES FES 14 732.021429 27 128 661 HAS;HEA;HEM Heme 12 600.012843 11 72 1419 CU;CU1;CUA CU 9 619.666667 12 137 146 HEC;HEM Heme 9 960.618254 1 538 455 FES FES 9 690.045455 10 96 3156 FE;FE2;MN;MN3;FEO;NI FE;MN;NI 8 371.833333 26 83 231 ER2;F4S;FSX;SF3;SF4 FES 7 409.010245 9 2266 693 FAD;FMN;ADE Nuc 7 181.688095 19 2280 829 FAD;FMN;ADE Nuc 7 325.032035 14 131 2669 HEB;HEM;SF4 Heme;FES 6 124.771429 9 2267 260 2MD;MGD;ADE Nuc 6 159.333333 8 88 97 F3S;SF4 FES 5 492.682828 8 767 653 FMN Nuc 5 195.67381 25 876 22 HEC Heme 5 136.666667 0 882 18 HEC Heme 5 2 0 1481 197 SF4 FES 5 64.989755 6 8 319 2MC;CAA;COS;GRA;UCC;FAD;FMN Nuc 4 121 12 122 5 FE2;HCN FE;FES 4 0 2 135 83 HEC;HEM Heme 4 0 1 138 15 HEC;HEM Heme 4 0 0 673 4 CO CO 4 10.433333 0 1526 10 SF4 FES 4 0 1 1754 8 HEM Heme 4 0 1 15 137 3NI;NI NI 3 60 6 24 1217 C1O;CU;CU1;C2O CU 3 0 6 95 193 FCO;FE2;FNE;NFU;NFV;NWN FE;FES;FE;NI 3 60 7 105 193 FE;FE2;MN;NI;FEO;GSH FE;MN;NI;Organic 3 0 4 113 358 FE;FEC;HEM FE;Heme 3 0 1 140 106 HEC;HEM Heme 3 0 1 834 5 FE2 FE 3 0 1 877 4 HEC Heme 3 0 0 883 18 HEC Heme 3 121 0 1153 4 CU CU 3 0 0 1350 95 SRM Heme 3 0 4 1475 114 SF4 FES 3 0 5 1476 30 SF4 FES 3 241 0 1479 27 SF4 FES 3 3.5 2 1494 30 SF4 FES 3 240 2 1519 20 SF4 FES 3 0 0 1774 16 HEM Heme 3 0 0 1775 16 HEM Heme 3 0 0 1882 2 MN MN 3 25.5 1 2269 887 FAD;ADE Nuc 3 121 24 16 76 4MO;W;6MO;MO;MOS MO;W 2 0 4 75 156 CU;CU1;FE CU;FE 2 0 5 84 197 F3S;SF4 FES 2 2 6 100 102 FE;FE2 FE 2 62.089177 1 121 24 FE;FE2 FE 2 0 5 143 3 ISW FE 2 0 1 279 2 NI NI 2 0 0 280 2 NI NI 2 0 0 336 10 9S8 FES 2 121 1 480 15 F3S FES 2 121 2 539 135 FES FES 2 121 10 674 4 CO CO 2 0 0 774 9 FMN Nuc 2 121 2 777 28 FMN Nuc 2 121 2 884 3 HEC Heme 2 0 0 1368 1 UQ1 Quinone 2 0 1 1480 48 SF4 FES 2 0 4 1483 13 SF4 FES 2 18.247619 2 1486 21 SF4 FES 2 121 1 1507 8 SF4 FES 2 0 2 1732 3 HEM Heme 2 0 0 1736 23 HEM Heme 2 297.17381 1 1746 10 HEM Heme 2 0 1 2411 16 FAD;ADE Nuc 2 0 2 12 74 2MO;MO;MOM;MOS;SMO;CUB MO;CU;MO 1 0 8 13 13 2MO;6MO MO 1 0 2 19 56 B12;BVQ Heme;CO 1 0 2 82 32 CUK;CUZ CU 1 0 1 106 3 FE;FES FE;FES 1 0 1 107 231 FE;FE2;NI FE;NI 1 0 6 132 36 HEC;HEM Heme 1 0 0 141 11 HEC;HEM Heme 1 0 1 142 3 HEC;HEM Heme 1 0 0 157 25 MSS;MTQ;MTV Nuc 1 0 2 168 10 PTE;PTT W 1 0 0 262 2 NI NI 1 0 1 337 10 9S8 FES 1 0 1 419 13 DCQ Quinone 1 0 1 421 44 DHE Heme 1 0 2 429 7 EMO Quinone 1 0 1 473 4 FC6 FE 1 0 0 540 37 FES FES 1 0 3 542 12 FES FES 1 0 1 553 10 FES FES 1 0 1 769 15 FMN Nuc 1 0 2 782 4 FMN Nuc 1 0 2 881 2 HEC Heme 1 0 0 885 3 HEC Heme 1 0 0 1019 3 NCO CO 1 0 0 1023 57 NCO CO 1 0 2 1046 6 CU CU 1 0 1 1098 2 CU CU 1 0 1 1225 2 FE FE 1 0 0 1361 13 TRQ Quinone 1 0 1 1362 68 TRQ Quinone 1 0 2 1373 10 UQ2 Quinone 1 0 1 1427 20 W W 1 0 0 1477 52 SF4 FES 1 0 2 1492 4 SF4 FES 1 0 1 1737 13 HEM Heme 1 0 2 1738 16 HEM Heme 1 0 1 1747 13 HEM Heme 1 0 0 1749 3 HEM Heme 1 0 0 1776 2 HEM Heme 1 0 1 1804 40 MN MN 1 0 3 1878 59 MN MN 1 0 1 1894 16 MN MN 1 0 3 2015 6 MN MN 1 0 1 2294 40 CAA;ADE Nuc 1 0 2 2324 26 NAD;ADE Nuc 1 0 1 2333 24 COA;HXC;ADE Nuc 1 0 1 2407 8 CO8;ADE Nuc 1 0 0 2418 10 NAP;ADE Nuc 1 0 1 2453 20 FAD;ADE Nuc 1 0 0 2468 40 PQN Quinone 1 0 1