"pathway","name","coef","se","p","n_genes","genes"
"R-HSA-166058","MyD88:Mal cascade initiated on plasma membrane",0.365430970737631,0.026315889242743,7.66701557338058e-44,37,"APP; ATF1; BTRC; CD14; CD36; CREB1; DUSP3; DUSP4; DUSP6; DUSP7; IRAK2; JUN; MAP2K6; MAP2K7; MAP3K1; MAP3K7; MAP3K8; MAPK1; MAPK10; MAPK11; MAPK14; MAPK3; MAPK8; MEF2A; MEF2C; NFKB1; NFKBIA; NFKBIB; NKIRAS1; NOD1; PELI2; PELI3; PPP2CA; PPP2R1A; PPP2R1B; PPP2R5D; RELA"
"R-HSA-168179","Toll Like Receptor TLR1:TLR2 Cascade",0.365430970737631,0.026315889242743,7.66701557338058e-44,37,"APP; ATF1; BTRC; CD14; CD36; CREB1; DUSP3; DUSP4; DUSP6; DUSP7; IRAK2; JUN; MAP2K6; MAP2K7; MAP3K1; MAP3K7; MAP3K8; MAPK1; MAPK10; MAPK11; MAPK14; MAPK3; MAPK8; MEF2A; MEF2C; NFKB1; NFKBIA; NFKBIB; NKIRAS1; NOD1; PELI2; PELI3; PPP2CA; PPP2R1A; PPP2R1B; PPP2R5D; RELA"
"R-HSA-168188","Toll Like Receptor TLR6:TLR2 Cascade",0.365430970737631,0.026315889242743,7.66701557338058e-44,37,"APP; ATF1; BTRC; CD14; CD36; CREB1; DUSP3; DUSP4; DUSP6; DUSP7; IRAK2; JUN; MAP2K6; MAP2K7; MAP3K1; MAP3K7; MAP3K8; MAPK1; MAPK10; MAPK11; MAPK14; MAPK3; MAPK8; MEF2A; MEF2C; NFKB1; NFKBIA; NFKBIB; NKIRAS1; NOD1; PELI2; PELI3; PPP2CA; PPP2R1A; PPP2R1B; PPP2R5D; RELA"
"R-HSA-181438","Toll Like Receptor 2 (TLR2) Cascade",0.365430970737631,0.026315889242743,7.66701557338058e-44,37,"APP; ATF1; BTRC; CD14; CD36; CREB1; DUSP3; DUSP4; DUSP6; DUSP7; IRAK2; JUN; MAP2K6; MAP2K7; MAP3K1; MAP3K7; MAP3K8; MAPK1; MAPK10; MAPK11; MAPK14; MAPK3; MAPK8; MEF2A; MEF2C; NFKB1; NFKBIA; NFKBIB; NKIRAS1; NOD1; PELI2; PELI3; PPP2CA; PPP2R1A; PPP2R1B; PPP2R5D; RELA"
"R-HSA-168164","Toll Like Receptor 3 (TLR3) Cascade",0.36239715265208,0.0263476731487562,4.79059733709402e-43,37,"APP; ATF1; BIRC2; BTRC; CASP8; CD14; CREB1; DUSP3; DUSP4; DUSP6; DUSP7; FADD; IKBKE; IRAK2; JUN; MAP2K6; MAP2K7; MAP3K7; MAP3K8; MAPK1; MAPK10; MAPK11; MAPK14; MAPK3; MAPK8; MEF2A; MEF2C; NFKB1; NFKBIA; NFKBIB; NKIRAS1; NOD1; PPP2CA; PPP2R1A; PPP2R1B; PPP2R5D; RELA"
"R-HSA-168181","Toll Like Receptor 7/8 (TLR7/8) Cascade",0.364411162548171,0.0265290522696095,6.15368838377418e-43,36,"APP; ATF1; BTRC; CD14; CREB1; DUSP3; DUSP4; DUSP6; DUSP7; IRAK2; JUN; MAP2K6; MAP2K7; MAP3K1; MAP3K7; MAP3K8; MAPK1; MAPK10; MAPK11; MAPK14; MAPK3; MAPK8; MEF2A; MEF2C; NFKB1; NFKBIA; NFKBIB; NKIRAS1; NOD1; PELI2; PELI3; PPP2CA; PPP2R1A; PPP2R1B; PPP2R5D; RELA"
"R-HSA-975155","MyD88 dependent cascade initiated on endosome",0.364411162548171,0.0265290522696095,6.15368838377418e-43,36,"APP; ATF1; BTRC; CD14; CREB1; DUSP3; DUSP4; DUSP6; DUSP7; IRAK2; JUN; MAP2K6; MAP2K7; MAP3K1; MAP3K7; MAP3K8; MAPK1; MAPK10; MAPK11; MAPK14; MAPK3; MAPK8; MEF2A; MEF2C; NFKB1; NFKBIA; NFKBIB; NKIRAS1; NOD1; PELI2; PELI3; PPP2CA; PPP2R1A; PPP2R1B; PPP2R5D; RELA"
"R-HSA-399719","Trafficking of AMPA receptors",-0.649401326128667,0.0476129429396159,2.34190600640142e-42,17,"AKAP5; AP2A2; AP2B1; AP2M1; CACNG2; CACNG4; CAMK2B; CAMK2D; GRIA1; GRIP1; GRIP2; MDM2; MYO6; NSF; PICK1; PRKCA; PRKCB"
"R-HSA-399721","Glutamate binding, activation of AMPA receptors and synaptic plasticity",-0.649401326128667,0.0476129429396159,2.34190600640142e-42,17,"AKAP5; AP2A2; AP2B1; AP2M1; CACNG2; CACNG4; CAMK2B; CAMK2D; GRIA1; GRIP1; GRIP2; MDM2; MYO6; NSF; PICK1; PRKCA; PRKCB"
"R-HSA-975138","TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation",0.356438168839854,0.0262185378989848,4.29399039910819e-42,38,"APP; ATF1; BTRC; CD14; CREB1; DUSP3; DUSP4; DUSP6; DUSP7; IRAK2; JUN; MAP2K6; MAP2K7; MAP3K1; MAP3K7; MAP3K8; MAPK1; MAPK10; MAPK11; MAPK14; MAPK3; MAPK8; MEF2A; MEF2C; NFKB1; NFKBIA; NFKBIB; NKIRAS1; NOD1; PELI2; PELI3; PPP2CA; PPP2R1A; PPP2R1B; PPP2R5D; RELA; RPS6KA1; RPS6KA2"
"R-HSA-167044","Signalling to RAS",0.668906656834565,0.0492724968067353,5.58385592355936e-42,11,"GRB2; KRAS; MAPK11; MAPK12; MAPK13; MAPK14; RALA; RALGDS; SHC2; SHC3; SRC"
"R-HSA-168138","Toll Like Receptor 9 (TLR9) Cascade",0.352492593126525,0.0266134624592852,4.82938143157036e-40,37,"APP; ATF1; BTRC; CD14; CREB1; DUSP3; DUSP4; DUSP6; DUSP7; EEA1; IRAK2; JUN; MAP2K6; MAP2K7; MAP3K1; MAP3K7; MAP3K8; MAPK1; MAPK10; MAPK11; MAPK14; MAPK3; MAPK8; MEF2A; MEF2C; NFKB1; NFKBIA; NFKBIB; NKIRAS1; NOD1; PELI2; PELI3; PIK3C3; PPP2CA; PPP2R1A; PPP2R1B; PPP2R5D"
"R-HSA-187687","Signalling to ERKs",0.576099705744575,0.0437775048349654,1.49639386075909e-39,18,"CRK; CRKL; GRB2; KIDINS220; KRAS; MAPK11; MAPK12; MAPK13; MAPK14; PLCG1; RALA; RALGDS; RAP1A; RIT1; RIT2; SHC2; SHC3; SRC"
"R-HSA-354192","Integrin alphaIIb beta3 signaling",0.631314988506658,0.0486451599073503,1.63166666053149e-38,12,"AKT1; BCAR1; CRK; GRB2; ITGB3; RAP1A; RAPGEF3; RAPGEF4; RASGRP1; SRC; TLN1; VWF"
"R-HSA-9006921","Integrin signaling",0.631314988506658,0.0486451599073503,1.63166666053149e-38,12,"AKT1; BCAR1; CRK; GRB2; ITGB3; RAP1A; RAPGEF3; RAPGEF4; RASGRP1; SRC; TLN1; VWF"
"R-HSA-447115","Interleukin-12 family signaling",0.606678976770293,0.046914120567884,2.98182005488106e-38,32,"ANXA2; ARF1; CA1; CANX; CFL1; CNN2; CRLF1; GSTO1; HNRNPDL; HNRNPF; HSPA9; IL12A; IL12RB1; IL12RB2; IL27RA; IL6ST; JAK1; JAK2; LCP1; LMNB1; MTAP; P4HB; PAK2; PITPNA; PSME2; RALA; RPLP0; SNRPA1; SOD1; SOD2; STAT3; TYK2"
"R-HSA-8950505","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation",0.69795927747078,0.0546806794646123,2.59553130195418e-37,20,"ANXA2; ARF1; CA1; CFL1; CNN2; GSTO1; HNRNPDL; HNRNPF; HSPA9; LCP1; LMNB1; MTAP; PAK2; PITPNA; PSME2; RALA; RPLP0; SNRPA1; SOD1; SOD2"
"R-HSA-166166","MyD88-independent TLR4 cascade ",0.32549357434426,0.0258625427683322,2.53663725115541e-36,38,"APP; ATF1; BIRC2; BTRC; CASP8; CD14; CREB1; DUSP3; DUSP4; DUSP6; DUSP7; FADD; IKBKE; IRAK2; JUN; MAP2K6; MAP2K7; MAP3K7; MAP3K8; MAPK1; MAPK10; MAPK11; MAPK14; MAPK3; MAPK8; MEF2A; MEF2C; NFKB1; NFKBIA; NFKBIB; NKIRAS1; NOD1; PPP2CA; PPP2R1A; PPP2R1B; PPP2R5D; PTPN11; RELA"
"R-HSA-937061","TRIF(TICAM1)-mediated TLR4 signaling ",0.32549357434426,0.0258625427683322,2.53663725115541e-36,38,"APP; ATF1; BIRC2; BTRC; CASP8; CD14; CREB1; DUSP3; DUSP4; DUSP6; DUSP7; FADD; IKBKE; IRAK2; JUN; MAP2K6; MAP2K7; MAP3K7; MAP3K8; MAPK1; MAPK10; MAPK11; MAPK14; MAPK3; MAPK8; MEF2A; MEF2C; NFKB1; NFKBIA; NFKBIB; NKIRAS1; NOD1; PPP2CA; PPP2R1A; PPP2R1B; PPP2R5D; PTPN11; RELA"
"R-HSA-9020591","Interleukin-12 signaling",0.618531070758286,0.0492509018339183,3.55791731833606e-36,27,"ANXA2; ARF1; CA1; CFL1; CNN2; GSTO1; HNRNPDL; HNRNPF; HSPA9; IL12A; IL12RB1; IL12RB2; JAK1; JAK2; LCP1; LMNB1; MTAP; P4HB; PAK2; PITPNA; PSME2; RALA; RPLP0; SNRPA1; SOD1; SOD2; TYK2"
"R-HSA-202670","ERKs are inactivated",0.525823814944229,0.0418868244888434,3.80599772215594e-36,11,"DUSP3; DUSP4; DUSP6; DUSP7; MAPK1; MAPK3; PPP2CA; PPP2R1A; PPP2R1B; PPP2R5D; VRK3"
"R-HSA-76009","Platelet Aggregation (Plug Formation)",0.594593909762555,0.0475277753248097,6.54514622637756e-36,13,"ADRA2C; AKT1; BCAR1; CRK; GRB2; ITGB3; RAP1A; RAPGEF3; RAPGEF4; RASGRP1; SRC; TLN1; VWF"
"R-HSA-416993","Trafficking of GluR2-containing AMPA receptors",-0.723316014202546,0.0580868454582098,1.35837508340711e-35,10,"AP2A2; AP2B1; AP2M1; GRIA1; GRIP1; GRIP2; NSF; PICK1; PRKCA; PRKCB"
"R-HSA-164938","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters",-0.638713363651176,0.0515022216362269,2.5594535491561e-35,11,"AP1B1; AP1M1; AP1S1; AP2A2; AP2B1; AP2M1; ARF1; ATP6V1H; CD4; HLA-A; PACS1"
"R-HSA-597592","Post-translational protein modification",0.563716642907809,0.0457381411946622,6.65507451944929e-35,31,"AAAS; ACTB; ACTL6A; ACTR10; ACTR8; ADAM10; ADAMTS1; ADAMTS13; ADAMTS14; ADAMTS17; ADAMTS18; ADAMTS19; ADAMTS2; ADAMTS3; ADAMTS5; ADAMTS6; ADAMTS8; ADAMTS9; ADAMTSL1; ADAMTSL2; ADAMTSL3; ADRB2; AGBL3; AGTPBP1; ALG1; ALG10; ALG12; ALG8; ALPL; AMFR; ANK1"
"R-HSA-5673000","RAF activation",0.550843043990481,0.0457092525227875,1.91568262702176e-33,11,"JAK2; KRAS; KSR1; PPP2CA; PPP2R1A; PPP2R1B; PPP2R5A; PPP2R5C; PPP2R5D; PPP2R5E; SRC"
"R-HSA-168142","Toll Like Receptor 10 (TLR10) Cascade",0.316261744697738,0.0262859760449335,2.42484350130039e-33,38,"APP; ATF1; BTRC; CREB1; DUSP3; DUSP4; DUSP6; DUSP7; IRAK2; JUN; MAP2K6; MAP2K7; MAP3K1; MAP3K7; MAP3K8; MAPK1; MAPK10; MAPK11; MAPK14; MAPK3; MAPK8; MEF2A; MEF2C; NFKB1; NFKBIA; NFKBIB; NKIRAS1; NOD1; PELI2; PELI3; PPP2CA; PPP2R1A; PPP2R1B; PPP2R5D; RELA; RPS6KA1; RPS6KA2; RPS6KA5"
"R-HSA-168176","Toll Like Receptor 5 (TLR5) Cascade",0.316261744697738,0.0262859760449335,2.42484350130039e-33,38,"APP; ATF1; BTRC; CREB1; DUSP3; DUSP4; DUSP6; DUSP7; IRAK2; JUN; MAP2K6; MAP2K7; MAP3K1; MAP3K7; MAP3K8; MAPK1; MAPK10; MAPK11; MAPK14; MAPK3; MAPK8; MEF2A; MEF2C; NFKB1; NFKBIA; NFKBIB; NKIRAS1; NOD1; PELI2; PELI3; PPP2CA; PPP2R1A; PPP2R1B; PPP2R5D; RELA; RPS6KA1; RPS6KA2; RPS6KA5"
"R-HSA-975871","MyD88 cascade initiated on plasma membrane",0.316261744697738,0.0262859760449335,2.42484350130039e-33,38,"APP; ATF1; BTRC; CREB1; DUSP3; DUSP4; DUSP6; DUSP7; IRAK2; JUN; MAP2K6; MAP2K7; MAP3K1; MAP3K7; MAP3K8; MAPK1; MAPK10; MAPK11; MAPK14; MAPK3; MAPK8; MEF2A; MEF2C; NFKB1; NFKBIA; NFKBIB; NKIRAS1; NOD1; PELI2; PELI3; PPP2CA; PPP2R1A; PPP2R1B; PPP2R5D; RELA; RPS6KA1; RPS6KA2; RPS6KA5"
"R-HSA-112316","Neuronal System",-0.460857713452375,0.0384917250209124,4.92735327165852e-33,33,"ABAT; ABCC8; ABCC9; ACHE; ADCY3; ADCY6; ADCY7; AKAP5; ALDH2; ALDH5A1; AP2A2; AP2B1; AP2M1; APBA2; ARL6IP5; BCHE; BEGAIN; CACNA1A; CACNA1B; CACNA1E; CACNA2D1; CACNA2D3; CACNB3; CACNG2; CACNG4; CALM1; CAMK2B; CAMK2D; CAMK4; CHRNA2; CHRNA4; CHRNA7; CHRNB2"
"R-HSA-164952","The role of Nef in HIV-1 replication and disease pathogenesis",-0.528005350966038,0.045877478964545,1.18805094010387e-30,15,"AP1B1; AP1M1; AP1S1; AP2A2; AP2B1; AP2M1; ARF1; ATP6V1H; CD4; DOCK2; ELMO1; FYN; HLA-A; PACS1; PAK2"
"R-HSA-198753","ERK/MAPK targets",0.40899062810803,0.0360344337549975,7.41672914228997e-30,18,"DUSP3; DUSP4; DUSP6; DUSP7; MAPK1; MAPK11; MAPK14; MAPK3; MEF2A; MEF2C; PPP2CA; PPP2R1A; PPP2R1B; PPP2R5D; RPS6KA1; RPS6KA2; RPS6KA5; VRK3"
"R-HSA-8964038","LDL clearance",-0.652457327904993,0.0575024958447055,7.71104185192699e-30,11,"AP2A2; AP2B1; AP2M1; APOB; CES3; CLTA; LDLRAP1; LSR; NPC1; NPC2; SOAT1"
"R-HSA-5663213","RHO GTPases Activate WASPs and WAVEs",0.479978902019544,0.0444921017223152,3.92413895359822e-27,22,"ABI2; ACTB; ACTG1; ACTR2; ARPC1A; ARPC1B; ARPC2; ARPC3; ARPC4; BRK1; CYFIP1; CYFIP2; GRB2; MAPK1; MAPK3; NCK1; NCKIPSD; WASF1; WASF3; WIPF1; WIPF2; WIPF3"
"R-HSA-112315","Transmission across Chemical Synapses",-0.397563844083271,0.0374511291530546,2.52339496279979e-26,32,"ABAT; ACHE; ADCY3; ADCY6; ADCY7; AKAP5; ALDH2; ALDH5A1; AP2A2; AP2B1; AP2M1; ARL6IP5; BCHE; CACNA1A; CACNA1B; CACNA1E; CACNA2D1; CACNA2D3; CACNB3; CACNG2; CACNG4; CALM1; CAMK2B; CAMK2D; CAMK4; CHRNA2; CHRNA4; CHRNA7; CHRNB2; COMT; CPLX1; CREB1"
"R-HSA-8964043","Plasma lipoprotein clearance",-0.567638006022229,0.0536454133750711,3.63889014918635e-26,18,"AP2A2; AP2B1; AP2M1; APOB; APOE; CES3; CLTA; CUBN; LDLRAP1; LSR; MYLIP; NPC1; NPC2; NR1H2; NR1H3; SCARB1; SOAT1; VLDLR"
"R-HSA-881907","Gastrin-CREB signalling pathway via PKC and MAPK",0.440854968172807,0.042479076707525,3.11701036636821e-25,10,"CCKBR; CREB1; EGFR; GRB2; KRAS; MAPK1; MAPK3; PRKCA; RPS6KA1; RPS6KA2"
"R-HSA-400253","Circadian Clock",-0.357140811126677,0.0349441116508999,1.60770788869691e-24,36,"ARNTL2; BHLHE40; BTRC; CARM1; CHD9; CLOCK; CPT1A; CREB1; CRTC1; CRTC2; CRTC3; CRY1; CSNK1D; F7; HDAC3; HIF1A; MEF2C; MEF2D; NAMPT; NCOA1; NCOA6; NCOR1; NFIL3; NPAS2; NR1D1; PER1; PER2; PPP1CB; RBM4; RORA; RXRA; SIRT1; SKP1; SMARCD3; TGS1; UBA52"
"R-HSA-392499","Metabolism of proteins",0.436945333413375,0.0429045666556619,2.33458189048747e-24,36,"AAAS; AARS2; ACADVL; ACE; ACHE; ACTB; ACTL6A; ACTR10; ACTR8; ADAM10; ADAMTS1; ADAMTS13; ADAMTS14; ADAMTS17; ADAMTS18; ADAMTS19; ADAMTS2; ADAMTS3; ADAMTS5; ADAMTS6; ADAMTS8; ADAMTS9; ADAMTSL1; ADAMTSL2; ADAMTSL3; ADD1; ADORA2B; ADRA2C; ADRB2; AGBL3; AGT; AGTPBP1; AIMP1; ALG1; ALG10; ALG12"
"R-HSA-112314","Neurotransmitter receptors and postsynaptic signal transmission",-0.405760795286508,0.0399535930786611,3.12231195494078e-24,23,"ADCY3; ADCY6; ADCY7; AKAP5; AP2A2; AP2B1; AP2M1; CACNG2; CACNG4; CALM1; CAMK2B; CAMK2D; CAMK4; CHRNA2; CHRNA4; CHRNA7; CHRNB2; CREB1; GABRA2; GABRA4; GABRA6; GABRB1; GABRG3"
"R-HSA-198725","Nuclear Events (kinase and transcription factor activation)",0.345931442131295,0.03415164799276,4.09674668030615e-24,20,"ATF1; CREB1; DUSP3; DUSP4; DUSP6; DUSP7; MAPK1; MAPK11; MAPK14; MAPK3; MEF2A; MEF2C; PPP2CA; PPP2R1A; PPP2R1B; PPP2R5D; RPS6KA1; RPS6KA2; RPS6KA5; VRK3"
"R-HSA-451927","Interleukin-2 family signaling",0.482438417619156,0.04874882273303,4.31479424769818e-23,13,"GRB2; HAVCR2; IL15; INPP5D; JAK1; JAK2; JAK3; PIK3CA; PIK3CB; PIK3CD; PIK3R1; SOS2; STAT3"
"R-HSA-5696398","Nucleotide Excision Repair",0.301393925359906,0.0305942948280752,6.76553797740175e-23,38,"ACTB; ACTL6A; ACTR8; AQR; CDK7; CHD1L; COPS2; COPS3; COPS6; COPS7A; CUL4A; ELL; ERCC1; ERCC2; ERCC3; ERCC4; ERCC5; ERCC6; ERCC8; GTF2H1; GTF2H2; GTF2H3; GTF2H4; INO80D; INO80E; ISY1; LIG1; LIG3; NFRKB; PARP1; PARP2; POLD2; POLD3; POLE; POLR2A; POLR2B; POLR2D; POLR2E"
"R-HSA-110320","Translesion Synthesis by POLH",-0.338983890756024,0.034861745276956,2.39022838867791e-22,13,"POLH; RCHY1; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3; SPRTN; UBA52; UBC"
"R-HSA-450282","MAPK targets/ Nuclear events mediated by MAP kinases",0.313686993532496,0.032377742381828,3.37934438150903e-22,23,"ATF1; CREB1; DUSP3; DUSP4; DUSP6; DUSP7; JUN; MAPK1; MAPK10; MAPK11; MAPK14; MAPK3; MAPK8; MEF2A; MEF2C; PPP2CA; PPP2R1A; PPP2R1B; PPP2R5D; RPS6KA1; RPS6KA2; RPS6KA5; VRK3"
"R-HSA-437239","Recycling pathway of L1",-0.42398796358905,0.0438368576130553,3.96739165232177e-22,13,"AP2A2; AP2B1; AP2M1; CLTA; DNM2; DNM3; MAPK1; NUMB; RPS6KA1; RPS6KA2; RPS6KA5; SH3GL2; SRC"
"R-HSA-8875878","MET promotes cell motility",0.482995789716958,0.0503103585112535,7.96927835928542e-22,17,"CRK; CRKL; DOCK7; GAB1; GRB2; ITGA2; ITGA3; LAMA1; LAMA2; LAMA5; LAMB3; LAMC1; LAMC3; MET; RAP1A; SRC; TNS3"
"R-HSA-110312","Translesion synthesis by REV1",-0.33587452191585,0.0350492032648372,9.43181579287177e-22,11,"REV3L; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3; UBA52; UBC"
"R-HSA-5655862","Translesion synthesis by POLK",-0.33587452191585,0.0350492032648372,9.43181579287177e-22,11,"REV3L; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3; UBA52; UBC"
"R-HSA-5656121","Translesion synthesis by POLI",-0.333800190780017,0.0349122860171268,1.16500928426054e-21,12,"POLI; REV3L; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3; UBA52; UBC"
"R-HSA-5205685","Pink/Parkin Mediated Mitophagy",-0.434748825749031,0.0460577029506681,3.75561922818656e-21,12,"ATG12; MAP1LC3A; MAP1LC3B; MFN1; MFN2; PINK1; TOMM22; TOMM40; TOMM7; UBA52; UBC; VDAC1"
"R-HSA-69206","G1/S Transition",0.248685295852807,0.0268241545616895,1.84501694413265e-20,38,"AKT1; AKT2; AKT3; CCNA1; CCNA2; CDC25A; CDC7; CDK2; CDK7; CDKN1A; CDKN1B; CKS1B; DBF4; DHFR; E2F1; E2F5; HDAC1; LIN52; LIN54; LIN9; MAX; MCM2; MCM3; MCM4; MCM6; MCM7; MCM8; MYC; ORC2; ORC4; ORC5; POLA2; POLE; PPP2CA; PPP2R1A; PPP2R1B; PRIM1; PSMA1"
"R-HSA-5689901","Metalloprotease DUBs",-0.355110024893139,0.0389170478570325,7.1873155117615e-20,11,"BARD1; HIST1H2AB; HIST1H2AC; KAT2B; MYSM1; NLRP3; STAM; STAMBPL1; UBA52; UBC; UIMC1"
"R-HSA-69273","Cyclin A/B1/B2 associated events during G2/M transition",0.390269253856647,0.0428190693749642,7.91218336187923e-20,14,"CCNA1; CCNA2; CDC25A; CDC25B; CDK2; CDK7; LCMT1; PLK1; PPME1; PPP2CA; PPP2R1A; PPP2R1B; WEE1; XPO1"
"R-HSA-381426","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)",0.542691740602962,0.0599859275390523,1.46971246319426e-19,22,"ADAM10; APLP2; APOB; APOE; APP; BMP4; CALU; CHGB; CP; CSF1; CST3; DNAJC3; F5; FAM20A; FSTL1; FUCA2; GOLM1; IGF1; IGFBP2; IGFBP5; IGFBP7; ITIH2"
"R-HSA-202733","Cell surface interactions at the vascular wall",0.509547312345997,0.056474123345439,1.83561816373327e-19,19,"ANGPT1; ANGPT2; APOB; ATP1B1; ATP1B2; ATP1B3; BSG; CAV1; CD44; CD84; CXADR; EPCAM; ESAM; F11R; FYN; GLG1; GRB2; GYPA; GYPC"
"R-HSA-2029482","Regulation of actin dynamics for phagocytic cup formation",0.422519674163094,0.0471436352351666,3.1771408378583e-19,21,"ABI2; ACTB; ACTG1; ACTR2; ARPC1A; ARPC1B; ARPC2; ARPC3; ARPC4; BRK1; CFL1; CRK; CYFIP1; CYFIP2; DOCK1; ELMO1; ELMO2; FCGR2A; GRB2; HSP90AA1; HSP90AB1"
"R-HSA-75893","TNF signaling",-0.33482666923945,0.0374308456720491,3.71252700664679e-19,20,"ADAM17; BAG4; BIRC2; CASP8; CLIP3; CYLD; FADD; MADD; MAP3K7; NSMAF; RBCK1; SMPD2; SPPL2A; TAB1; TAB2; TNFAIP3; TRADD; TRAF1; UBA52; UBC"
"R-HSA-983705","Signaling by the B Cell Receptor (BCR)",0.430111303556306,0.0481797764812085,4.36861254160557e-19,10,"AHCYL1; BLNK; BTRC; CALM1; CARD11; CBL; CD22; FKBP1A; FYN; GRB2"
"R-HSA-388841","Costimulation by the CD28 family",0.266771985767238,0.0299700675579084,5.52059172888342e-19,26,"AKT1; AKT2; AKT3; CD274; CD4; FYN; GRB2; LYN; MAP3K8; MLST8; MTOR; PAK1; PAK2; PIK3CA; PIK3R1; PPP2CA; PPP2R1A; PPP2R1B; PPP2R5A; PPP2R5C; PPP2R5D; PPP2R5E; PRR5; PTPN11; RICTOR; SRC"
"R-HSA-1362300","Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1",0.5008330079691,0.0565335024063239,8.07006640498256e-19,11,"CCNA2; E2F1; E2F5; HDAC1; LIN52; LIN54; LIN9; RBBP4; RBL1; RBL2; TFDP1"
"R-HSA-73887","Death Receptor Signalling",-0.321455024505185,0.0364443850543449,1.14024438788976e-18,25,"ADAM17; BAG4; BIRC2; CASP10; CASP8; CLIP3; CYLD; FADD; FAS; MADD; MAP3K7; NSMAF; RBCK1; SMPD2; SPPL2A; TAB1; TAB2; TNFAIP3; TNFRSF10A; TNFRSF10B; TNFSF10; TRADD; TRAF1; UBA52; UBC"
"R-HSA-389356","CD28 co-stimulation",0.303235360600272,0.0346929390209929,2.31978728240509e-18,19,"AKT1; AKT2; AKT3; FYN; GRB2; LYN; MAP3K8; MLST8; MTOR; PAK1; PAK2; PIK3CA; PIK3R1; PRR5; RICTOR; SRC; THEM4; TRIB3; YES1"
"R-HSA-375165","NCAM signaling for neurite out-growth",0.32744001801294,0.0375162650344405,2.59334366870111e-18,27,"CACNA1C; CACNA1D; CACNA1G; CACNA1I; CACNB3; CNTN2; COL4A4; COL6A1; COL6A2; COL6A3; CREB1; FGFR1; FYN; GFRA1; GFRA2; GRB2; KRAS; MAPK1; MAPK3; NCAN; RPS6KA5; SPTB; SPTBN1; SPTBN2; SPTBN4; SPTBN5; SRC"
"R-HSA-9006936","Signaling by TGF-beta family members",0.373397562095125,0.0428657670367303,3.01586222554786e-18,37,"ACVR2B; ACVRL1; ARHGEF18; BAMBI; BMP2; BMPR1A; BMPR1B; CBL; CCNK; CCNT1; CCNT2; CDK8; CDK9; CDKN2B; DRAP1; E2F5; F11R; FKBP1A; FSTL1; FURIN; GREM2; HDAC1; INHBA; MTMR4; MYC; NCOR1; NCOR2; NOG; PARD6A; PARP1; PMEPA1; PPM1A; PPP1CB; PPP1R15A; RBL1; SKIL; SMAD1"
"R-HSA-2132295","MHC class II antigen presentation",-0.323106872468841,0.0379374576002851,1.63980103647956e-17,30,"ACTR10; ACTR1B; AP1B1; AP1M1; AP1S1; AP2A2; AP2B1; AP2M1; ARF1; CANX; CAPZA2; CAPZB; CENPE; CLTA; CTSA; CTSB; CTSC; CTSD; CTSH; CTSK; CTSO; CTSS; DCTN3; DCTN5; DCTN6; DNM2; DNM3; DYNC1H1; DYNC1LI2; DYNLL2"
"R-HSA-162588","Budding and maturation of HIV virion",-0.371991758323583,0.043800331169893,2.01546648193501e-17,15,"CHMP2A; CHMP2B; CHMP3; CHMP4A; CHMP4B; CHMP7; MVB12A; MVB12B; PDCD6IP; UBA52; UBC; VPS28; VPS37A; VPS4A; VTA1"
"R-HSA-5633007","Regulation of TP53 Activity",0.250206438855425,0.0294617526568422,2.02090891790463e-17,40,"AKT1; AKT2; AKT3; ATM; ATRIP; BARD1; BLM; BRD7; BRIP1; BRPF1; CCNA1; CCNA2; CCNG1; CDK2; CDK5; CDK5R1; CHEK1; CSNK2A2; DNA2; DYRK2; EHMT1; EXO1; GATAD2A; HDAC1; HDAC2; ING2; JMY; KAT6A; L3MBTL1; MAP2K6; MAPK11; MAPK14; MAPKAPK5; MBD3; MDM2; MDM4; MEAF6; MLST8; MTOR; NBN"
"R-HSA-180024","DARPP-32 events",0.387544027158954,0.0458605957472517,2.90108693719481e-17,17,"CALM1; CDK5; PDE4A; PDE4B; PDE4C; PDE4D; PPP2CA; PPP2R1A; PPP2R1B; PPP2R5D; PPP3CB; PPP3CC; PPP3R1; PRKACA; PRKAR1A; PRKAR1B; PRKAR2A"
"R-HSA-381340","Transcriptional regulation of white adipocyte differentiation",-0.410887001652067,0.0488041954196572,3.7941401154315e-17,33,"ANGPTL4; CARM1; CCND3; CD36; CDK8; CEBPB; CHD9; FAM120B; HDAC3; KLF4; MED10; MED13; MED16; MED17; MED19; MED20; MED23; MED24; MED27; MED28; MED30; MED4; MED6; MED7; MED8; MED9; NCOA1; NCOA3; NCOA6; NCOR1; NCOR2; NFKB1; PLIN1"
"R-HSA-110314","Recognition of DNA damage by PCNA-containing replication complex",-0.2627656491594,0.0312140566753269,3.82367359206207e-17,16,"CUL4A; POLD2; POLD3; POLE; RAD18; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3; UBA52; UBC; USP1"
"R-HSA-174824","Plasma lipoprotein assembly, remodeling, and clearance",-0.36222850883901,0.0433888136485476,6.91758475339528e-17,34,"A2M; ABCA1; ABCG1; ANGPTL3; ANGPTL4; AP2A2; AP2B1; AP2M1; APOB; APOE; BMP1; CES3; CLTA; CUBN; FURIN; GPIHBP1; LDLRAP1; LIPG; LMF2; LSR; MBTPS1; MYLIP; NPC1; NPC2; NR1H2; NR1H3; P4HB; PCSK5; PCSK6; PLTP; PRKACA; SAR1B; SCARB1; SOAT1"
"R-HSA-5696397","Gap-filling DNA repair synthesis and ligation in GG-NER",-0.256587072395256,0.0307637526132933,7.39365278629819e-17,16,"LIG1; LIG3; POLD2; POLD3; POLE; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3; UBA52; UBC; XRCC1"
"R-HSA-5689896","Ovarian tumor domain proteases",-0.331115825150459,0.0399362605314111,1.12198918357416e-16,16,"DDX58; ESR1; NOD1; OTUB1; OTUB2; OTUD3; OTUD7A; PTEN; RNF135; TNFAIP3; TNIP2; TP53; TRAF6; TRIM25; UBA52; UBC"
"R-HSA-6804760","Regulation of TP53 Activity through Methylation",-0.333154034215374,0.040194732144341,1.14685639252792e-16,12,"ATM; EHMT1; JMY; L3MBTL1; MDM2; MDM4; SETD9; SMYD2; TP53; TTC5; UBA52; UBC"
"R-HSA-8957275","Post-translational protein phosphorylation",0.489377194091902,0.0593513879246013,1.64579412100703e-16,24,"ADAM10; APLP2; APOB; APOE; APP; BMP4; CALU; CHGB; CP; CSF1; CST3; DNAJC3; F5; FAM20A; FSTL1; FUCA2; GOLM1; IGFBP5; IGFBP7; ITIH2; KTN1; LAMC1; LTBP1; MBTPS1"
"R-HSA-6783310","Fanconi Anemia Pathway",-0.302027850283422,0.0366442535818187,1.69127288750889e-16,20,"ATRIP; DCLRE1A; DCLRE1B; EME2; ERCC1; ERCC4; FAN1; FANCA; FANCC; FANCF; FANCG; FANCM; POLN; RPA1; RPA2; RPA3; UBA52; UBC; UBE2T; USP1"
"R-HSA-392451","G beta:gamma signalling through PI3Kgamma",0.268706746794531,0.0326579836537809,1.90518037168699e-16,20,"AKT1; AKT2; AKT3; GNB2; GNB3; GNB4; GNB5; GNG11; GNG4; GNG5; GNG7; GRB2; JAK1; JAK2; JAK3; PIK3CA; PIK3CB; PIK3CD; PIK3R1; PIK3R5"
"R-HSA-397795","G-protein beta:gamma signalling",0.260016724150466,0.0321776546220053,6.44165620135914e-16,22,"AKT1; AKT2; AKT3; GNB2; GNB3; GNB4; GNB5; GNG11; GNG4; GNG5; GNG7; GRB2; JAK1; JAK2; JAK3; PIK3CA; PIK3CB; PIK3CD; PIK3R1; PIK3R5; PLCB1; PLCB3"
"R-HSA-2029480","Fcgamma receptor (FCGR) dependent phagocytosis",0.351630651616026,0.0435737393129583,7.04228109281517e-16,24,"ABI2; ACTB; ACTG1; ACTR2; AHCYL1; ARPC1A; ARPC1B; ARPC2; ARPC3; ARPC4; BRK1; CFL1; CRK; CYFIP1; CYFIP2; DOCK1; ELMO1; ELMO2; FCGR2A; FGR; FYN; GRB2; HSP90AA1; HSP90AB1"
"R-HSA-73893","DNA Damage Bypass",-0.242258735155511,0.0300590417626221,7.66511828251419e-16,23,"CUL4A; POLD2; POLD3; POLE; POLH; POLI; RAD18; RCHY1; REV3L; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3; SPRTN; TRIM25; UBA52; UBC; USP1; USP10"
"R-HSA-186763","Downstream signal transduction",0.314988065330337,0.0391629178867945,8.76522304179257e-16,17,"BCAR1; CRK; CRKL; GRB2; KRAS; NCK1; PDGFA; PDGFRA; PIK3CA; PIK3CB; PIK3R1; PLCG1; PTPN11; RASA1; SRC; STAT3; STAT6"
"R-HSA-2122948","Activated NOTCH1 Transmits Signal to the Nucleus",-0.286846019808897,0.0357531634892646,1.03231222144965e-15,13,"ADAM10; ADAM17; ARRB1; ARRB2; DLL4; JAG1; MIB1; NOTCH1; NUMB; PSEN1; PSEN2; UBA52; UBC"
"R-HSA-212165","Epigenetic regulation of gene expression",0.222262571817937,0.0277141359817643,1.05894332015522e-15,32,"ACTB; AEBP2; ARID4B; CBX3; CD3EAP; CDK7; DEK; DNMT3B; ERCC2; ERCC3; ERCC6; EZH2; GATAD2A; GSK3B; GTF2H1; GTF2H2; GTF2H3; GTF2H4; H2AFV; H2AFZ; H3F3A; HDAC1; HDAC2; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; KAT2B"
"R-HSA-1368108","BMAL1:CLOCK,NPAS2 activates circadian gene expression",-0.398097683054812,0.049681141566732,1.11894242984016e-15,25,"ARNTL2; BHLHE40; CARM1; CHD9; CLOCK; CREB1; CRTC1; CRY1; F7; HDAC3; HIF1A; NAMPT; NCOA1; NCOA6; NCOR1; NFIL3; NPAS2; NR1D1; PER1; PER2; RBM4; RORA; RXRA; SMARCD3; TGS1"
"R-HSA-113510","E2F mediated regulation of DNA replication",0.39549324112036,0.0493611844550463,1.12645494335421e-15,12,"E2F1; MCM8; ORC2; ORC4; ORC5; POLA2; PPP2CA; PPP2R1A; PPP2R1B; PRIM1; RB1; TFDP1"
"R-HSA-1250196","SHC1 events in ERBB2 signaling",0.373047134804455,0.0465920066622269,1.17849758319989e-15,13,"BTC; EGF; EGFR; ERBB2; ERBB3; ERBB4; GRB2; KRAS; NRG2; NRG4; PRKCA; PRKCD; PTPN12"
"R-HSA-453279","Mitotic G1-G1/S phases",0.236947253331862,0.0296020296250058,1.20025280302702e-15,38,"AKT1; AKT2; AKT3; CCNA1; CCNA2; CCND2; CCND3; CDC25A; CDC7; CDK2; CDK6; CDK7; CDKN1A; CDKN1B; CDKN2B; CDKN2C; CKS1B; DBF4; DHFR; E2F1; E2F5; HDAC1; JAK2; LIN52; LIN54; LIN9; LYN; MAX; MCM2; MCM3; MCM4; MCM6; MCM7; MCM8; MYC; ORC2; ORC4; ORC5"
"R-HSA-2173788","Downregulation of TGF-beta receptor signaling",-0.341840551051647,0.0427124885971668,1.211354674253e-15,13,"BAMBI; MTMR4; PMEPA1; PPP1CB; PPP1R15A; SMAD3; SMAD7; SMURF1; TGFB1; TGFBR2; UBA52; UBC; XPO1"
"R-HSA-5656169","Termination of translesion DNA synthesis",-0.242279289769182,0.030533465432424,2.10704194325478e-15,17,"POLD2; POLD3; POLE; POLH; POLI; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3; TRIM25; UBA52; UBC; USP10"
"R-HSA-917729","Endosomal Sorting Complex Required For Transport (ESCRT)",-0.331671871978318,0.0419655318328481,2.71319687936292e-15,19,"CHMP2A; CHMP2B; CHMP3; CHMP4A; CHMP4B; CHMP7; MVB12A; MVB12B; SNF8; STAM; STAM2; UBA52; UBC; VPS25; VPS28; VPS36; VPS37A; VPS4A; VTA1"
"R-HSA-5357905","Regulation of TNFR1 signaling",-0.328868223311561,0.0418084857163961,3.65973439067705e-15,12,"BIRC2; CASP8; CLIP3; CYLD; MADD; RBCK1; SPPL2A; TNFAIP3; TRADD; TRAF1; UBA52; UBC"
"R-HSA-110313","Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template",-0.237327911197466,0.0302002809952817,3.88863177569324e-15,20,"POLD2; POLD3; POLE; POLH; POLI; RCHY1; REV3L; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3; SPRTN; TRIM25; UBA52; UBC; USP10"
"R-HSA-73864","RNA Polymerase I Transcription",0.191019016505291,0.0244618106403321,5.77045274286083e-15,37,"CBX3; CD3EAP; CDK7; ERCC2; ERCC3; ERCC6; GATAD2A; GTF2H1; GTF2H2; GTF2H3; GTF2H4; H2AFV; H2AFZ; H3F3A; HDAC1; HDAC2; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; KAT2B; MAPK3; MBD3; MTA3; POLR1A; POLR1B; POLR1C; POLR1D; POLR1E; POLR2E; POLR2H; POLR2K; POLR2L"
"R-HSA-917937","Iron uptake and transport",-0.285822066820598,0.0366735325475236,6.50811828270754e-15,35,"ACO1; ALAD; ATP6V0A2; ATP6V0B; ATP6V0C; ATP6V0D1; ATP6V0E1; ATP6V0E2; ATP6V1C1; ATP6V1C2; ATP6V1E1; ATP6V1E2; ATP6V1G1; ATP6V1H; CAND1; CP; CYBRD1; FLVCR1; FTH1; FTL; GLRX3; HMOX1; HMOX2; IREB2; MCOLN1; SKP1; SLC22A17; SLC40A1; SLC46A1; STEAP2; STEAP3; TF; TFR2; UBA52; UBC"
"R-HSA-166016","Toll Like Receptor 4 (TLR4) Cascade",0.225037420871194,0.0289556689812781,7.73837779225818e-15,34,"APP; ATF1; BIRC2; BTRC; CASP8; CD14; CD36; CREB1; DNM2; DNM3; DUSP3; DUSP4; DUSP6; DUSP7; FADD; IKBKE; IRAK2; ITGB2; JUN; LY86; MAP2K6; MAP2K7; MAP3K1; MAP3K7; MAP3K8; MAPK1; MAPK10; MAPK11; MAPK14; MAPK3; MAPK8; MEF2A; MEF2C; NFKB1"
"R-HSA-2173789","TGF-beta receptor signaling activates SMADs",-0.298423152737825,0.0384549782925655,8.47116151712564e-15,16,"BAMBI; CBL; FKBP1A; FURIN; MTMR4; PMEPA1; PPP1CB; PPP1R15A; SMAD3; SMAD7; SMURF1; TGFB1; TGFBR2; UBA52; UBC; XPO1"
"R-HSA-73854","RNA Polymerase I Promoter Clearance",0.187120672261826,0.0243831529726358,1.66481906159884e-14,37,"CD3EAP; CDK7; ERCC2; ERCC3; ERCC6; GATAD2A; GTF2H1; GTF2H2; GTF2H3; GTF2H4; H2AFV; H2AFZ; H3F3A; HDAC1; HDAC2; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; KAT2B; MAPK3; MBD3; MTA3; POLR1A; POLR1B; POLR1C; POLR1D; POLR1E; POLR2E; POLR2H; POLR2K; POLR2L; RBBP4"
"R-HSA-8864260","Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors",0.457468428563911,0.0596719604348164,1.76906873410952e-14,21,"APOE; ATAD2; CDKN1A; CITED4; DEK; EGFR; ERBB2; ESR1; HSPD1; KCTD15; KDM5B; KIT; MYC; NOP2; NPM1; TFAP2E; TGFA; UBE2I; VEGFA; WWOX; YEATS4"
"R-HSA-453274","Mitotic G2-G2/M phases",0.254040711030281,0.0331630582924608,1.85423675980075e-14,35,"AJUBA; ALMS1; BORA; BTRC; CCNA1; CCNA2; CDC25A; CDC25B; CDK11A; CDK11B; CDK2; CDK5RAP2; CDK7; CDKN1A; CENPJ; CEP135; CEP164; CEP192; CEP250; CEP290; CEP41; CEP57; CEP63; CEP72; CEP76; CKAP5; CNTRL; CSNK1D; DCTN3; DYNC1H1; E2F1; HAUS1; HAUS2; HAUS4; HAUS5"
"R-HSA-1433559","Regulation of KIT signaling",0.390839345334825,0.0513043484246333,2.57526679333938e-14,11,"CBL; FYN; GRB2; KIT; KITLG; LYN; PRKCA; SH2B2; SH2B3; SRC; YES1"
"R-HSA-8866652","Synthesis of active ubiquitin: roles of E1 and E2 enzymes",-0.332346418784503,0.0442366164236765,5.78202840329089e-14,14,"UBA52; UBC; UBE2E1; UBE2E3; UBE2G1; UBE2G2; UBE2H; UBE2K; UBE2L3; UBE2Q2; UBE2R2; UBE2T; UBE2Z; UCHL3"
"R-HSA-901032","ER Quality Control Compartment (ERQC)",-0.32554313629949,0.0433809413709977,6.17627430108605e-14,12,"AMFR; EDEM2; EDEM3; MAN1B1; MARCH6; RNF185; SYVN1; TRIM13; UBA52; UBC; UGGT1; UGGT2"
"R-HSA-5668914","Diseases of metabolism",-0.298808693585001,0.0399888995720742,7.88104939389611e-14,18,"ACACA; CD320; CUBN; FDX1; FDXR; GYG1; MCCC1; MCCC2; MMAA; MTR; MTRR; PCCB; POMC; SFTPD; TCN2; TTF1; UBA52; UBC"
"R-HSA-69275","G2/M Transition",0.248619409012219,0.0338549289828416,2.07815938533385e-13,34,"AJUBA; ALMS1; BORA; BTRC; CCNA1; CCNA2; CDC25A; CDC25B; CDK11A; CDK11B; CDK2; CDK5RAP2; CDK7; CDKN1A; CENPJ; CEP135; CEP164; CEP192; CEP250; CEP290; CEP41; CEP57; CEP63; CEP72; CEP76; CKAP5; CNTRL; CSNK1D; DCTN3; DYNC1H1; HAUS1; HAUS2; HAUS4; HAUS5"
"R-HSA-389513","CTLA4 inhibitory signaling",0.27139506364939,0.037053730613858,2.40031784247762e-13,15,"AKT1; AKT2; AKT3; FYN; LYN; PPP2CA; PPP2R1A; PPP2R1B; PPP2R5A; PPP2R5C; PPP2R5D; PPP2R5E; PTPN11; SRC; YES1"
"R-HSA-168898","Toll-Like Receptors Cascades",0.242163905158237,0.0330989246152283,2.54772833693057e-13,32,"APOB; APP; ATF1; BIRC2; BTRC; CASP8; CD14; CD36; CREB1; CTSB; CTSK; CTSS; DNM2; DNM3; DUSP3; DUSP4; DUSP6; DUSP7; EEA1; FADD; IKBKE; IRAK2; ITGB2; JUN; LGMN; LY86; MAP2K6; MAP2K7; MAP3K1; MAP3K7; MAP3K8; MAPK1"
"R-HSA-114604","GPVI-mediated activation cascade",0.262121484174055,0.0359518199531392,3.07868351722077e-13,22,"AKT1; AKT2; AKT3; FYN; GRB2; JAK1; JAK2; JAK3; LCP2; LYN; PDPN; PIK3CA; PIK3CB; PIK3CD; PIK3R1; PIK3R5; PLCG2; PTPN11; RHOB; RHOG; VAV2; VAV3"
"R-HSA-937072","TRAF6-mediated induction of TAK1 complex within TLR4 complex",-0.260374244707044,0.0358389657833059,3.72718207824246e-13,11,"CD14; IRAK2; MAP3K7; SARM1; TAB1; TAB2; TICAM1; TLR4; TRAF6; UBA52; UBC"
"R-HSA-9014325","TICAM1,TRAF6-dependent induction of TAK1 complex",-0.259579559711005,0.0358420899917094,4.41103171104203e-13,10,"CD14; IRAK2; MAP3K7; TAB1; TAB2; TICAM1; TLR4; TRAF6; UBA52; UBC"
"R-HSA-975163","IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation",-0.259579559711005,0.0358420899917094,4.41103171104203e-13,10,"CD14; IRAK2; MAP3K7; TAB1; TAB2; TICAM1; TLR4; TRAF6; UBA52; UBC"
"R-HSA-6804758","Regulation of TP53 Activity through Acetylation",0.317969582846628,0.0444716898452083,8.68205493560564e-13,17,"AKT1; AKT2; AKT3; BRD7; BRPF1; GATAD2A; HDAC1; HDAC2; ING2; KAT6A; MAP2K6; MBD3; MEAF6; PIP4K2A; PML; RBBP4; TP53"
"R-HSA-933542","TRAF6 mediated NF-kB activation",0.400152221327728,0.0562341252680051,1.11244988675026e-12,12,"APP; DDX58; MAP3K1; NFKB1; NFKBIA; NFKBIB; NKIRAS1; RELA; RNF135; S100B; TRAF6; TRIM25"
"R-HSA-5685942","HDR through Homologous Recombination (HRR)",-0.177162871558541,0.0249621537546964,1.27255401346896e-12,38,"ATM; ATRIP; BARD1; BLM; BRCA2; BRIP1; CHEK1; DNA2; EME2; EXO1; NBN; PALB2; POLD2; POLD3; POLE; POLH; RAD1; RAD50; RAD51B; RAD51C; RAD9A; RFC1; RFC2; RFC3; RFC4; RFC5; RMI1; RMI2; RPA1; RPA2; RPA3; SPIDR; TOP3A; TOPBP1; UBA52; UBC; WRN; XRCC2"
"R-HSA-186797","Signaling by PDGF",0.261160877259976,0.0371249045080147,1.99755324468097e-12,27,"BCAR1; COL4A4; COL6A1; COL6A2; COL6A3; CRK; CRKL; FURIN; GRB2; KRAS; NCK1; PDGFA; PDGFD; PDGFRA; PIK3CA; PIK3CB; PIK3R1; PLCG1; PTPN11; PTPN12; RASA1; SRC; STAT3; STAT6; THBS2; THBS3; THBS4"
"R-HSA-5205647","Mitophagy",-0.256893573657561,0.0365825259170015,2.18240935017633e-12,15,"ATG12; CSNK2A2; MAP1LC3A; MAP1LC3B; MFN1; MFN2; PINK1; SRC; TOMM22; TOMM40; TOMM7; UBA52; UBC; ULK1; VDAC1"
"R-HSA-6807070","PTEN Regulation",0.241349507597616,0.0344249073235697,2.36793634549538e-12,28,"AGO2; AKT1; AKT2; AKT3; ATN1; CBX4; CNOT6L; CSNK2A2; EGR1; EZH2; FRK; GATAD2A; HDAC1; HDAC2; HDAC3; HDAC5; JUN; LAMTOR3; LAMTOR4; LAMTOR5; MAPK1; MAPK3; MBD3; MLST8; MTA3; MTOR; NEDD4; NR2E1"
"R-HSA-936440","Negative regulators of DDX58/IFIH1 signaling",-0.271433961791982,0.03872066755856,2.382265444798e-12,15,"ATG12; CYLD; DDX58; HERC5; IKBKE; NLRC5; NLRX1; RNF135; RNF216; TBK1; TNFAIP3; TRIM25; UBA52; UBC; UBE2K"
"R-HSA-1433557","Signaling by SCF-KIT",0.258257931721415,0.0369437789763306,2.73779119571859e-12,22,"CBL; CHEK1; FER; FES; FYN; GRB2; JAK2; KIT; KITLG; KRAS; LYN; PIK3CA; PIK3R1; PRKCA; PTPN11; PTPRU; SH2B2; SH2B3; SRC; STAT3; TEC; YES1"
"R-HSA-8848021","Signaling by PTK6",-0.188585559003486,0.0270149233628893,2.93520756762179e-12,33,"AKT1; ARAP1; BCAR1; BTC; CBL; CDK2; CDKN1B; CRK; DOCK1; EGF; EGFR; ELMO1; ELMO2; ERBB2; ERBB3; ERBB4; GPNMB; HIF1A; KHDRBS1; KHDRBS2; KHDRBS3; KRAS; LRRK2; NRG2; NRG4; PELP1; PXN; RASA1; SFPQ; STAP2; STAT3; UBA52; UBC"
"R-HSA-9006927","Signaling by Non-Receptor Tyrosine Kinases",-0.188585559003486,0.0270149233628893,2.93520756762179e-12,33,"AKT1; ARAP1; BCAR1; BTC; CBL; CDK2; CDKN1B; CRK; DOCK1; EGF; EGFR; ELMO1; ELMO2; ERBB2; ERBB3; ERBB4; GPNMB; HIF1A; KHDRBS1; KHDRBS2; KHDRBS3; KRAS; LRRK2; NRG2; NRG4; PELP1; PXN; RASA1; SFPQ; STAP2; STAT3; UBA52; UBC"
"R-HSA-168928","DDX58/IFIH1-mediated induction of interferon-alpha/beta",0.353089315845802,0.0507003711450227,3.30192271077014e-12,24,"APP; ATG12; CASP10; CASP8; CYLD; DDX58; DHX58; FADD; HERC5; IKBKE; IRF2; MAP3K1; NFKB1; NFKBIA; NFKBIB; NKIRAS1; NLRC5; NLRX1; RELA; RNF135; RNF216; S100B; SIKE1; TBK1"
"R-HSA-8982491","Glycogen metabolism",-0.258033152010744,0.0371060592928274,3.55233461267471e-12,15,"AGL; CALM1; GAA; GYG1; NHLRC1; PGM1; PGM2; PGM2L1; PHKB; PHKG1; PYGB; PYGL; PYGM; UBA52; UBC"
"R-HSA-2565942","Regulation of PLK1 Activity at G2/M Transition",0.245696617559379,0.0354429312435397,4.14417543182447e-12,40,"AJUBA; ALMS1; BORA; BTRC; CDK5RAP2; CENPJ; CEP135; CEP164; CEP192; CEP250; CEP290; CEP41; CEP57; CEP63; CEP72; CEP76; CKAP5; CNTRL; CSNK1D; DCTN3; DYNC1H1; HAUS1; HAUS2; HAUS4; HAUS5; HSP90AA1; MAPRE1; NDE1; NEDD1; NEK2; NINL; ODF2; OPTN; PAFAH1B1; PCM1; PCNT; PLK1; PLK4; PPP1CB; PPP2R1A"
"R-HSA-2172127","DAP12 interactions",0.299938557074387,0.0433274141824584,4.4341412836089e-12,15,"FYN; GRB2; HLA-B; HLA-C; HLA-E; KLRC2; KRAS; LCP2; PIK3CA; PIK3CB; PIK3R1; PLCG1; PLCG2; VAV2; VAV3"
"R-HSA-6782210","Gap-filling DNA repair synthesis and ligation in TC-NER",-0.14749704369212,0.021429965391341,5.87089812358255e-12,39,"AQR; CDK7; CUL4A; ERCC2; ERCC3; ERCC6; ERCC8; GTF2H1; GTF2H2; GTF2H3; GTF2H4; ISY1; LIG1; LIG3; POLD2; POLD3; POLE; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L; PPIE; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3; UBA52; UBC; UVSSA; XAB2; XRCC1"
"R-HSA-1500931","Cell-Cell communication",0.391778199564962,0.0570031750675851,6.29013285425606e-12,25,"CADM3; CD151; CD2AP; CDH1; CDH10; CDH13; CDH18; CDH3; CDH4; CDH6; CDH8; CDH9; CLDN1; CLDN11; CLDN12; CLDN15; CLDN16; CTNNA1; F11R; FBLIM1; FLNC; FYN; GRB2; ILK; IQGAP1"
"R-HSA-539107","Activation of E2F1 target genes at G1/S",0.367820280373383,0.0537444610314783,7.70801157503117e-12,14,"CCNA1; CDC25A; DHFR; E2F1; E2F5; HDAC1; LIN52; LIN54; LIN9; RBBP4; RBL1; RBL2; TFDP1; TYMS"
"R-HSA-69205","G1/S-Specific Transcription",0.367820280373383,0.0537444610314783,7.70801157503117e-12,14,"CCNA1; CDC25A; DHFR; E2F1; E2F5; HDAC1; LIN52; LIN54; LIN9; RBBP4; RBL1; RBL2; TFDP1; TYMS"
"R-HSA-2151201","Transcriptional activation of mitochondrial biogenesis",-0.252471274446665,0.0369003398407105,7.81076617022849e-12,31,"ACSS2; CALM1; CAMK4; CARM1; CHD9; CREB1; CRTC1; CRTC2; CRTC3; CYCS; HDAC3; IDH2; MEF2C; MEF2D; NCOA1; NCOA6; NCOR1; NR1D1; NRF1; POLRMT; PPRC1; RXRA; SIRT4; SIRT5; SMARCD3; SOD2; SSBP1; TFAM; TFB1M; TFB2M; TGS1"
"R-HSA-5663205","Infectious disease",-0.186071464589925,0.0272061806812333,7.95763174124051e-12,41,"AAAS; ANTXR1; ANTXR2; AP1B1; AP1M1; AP1S1; AP2A2; AP2B1; AP2M1; APOBEC3G; ARF1; ATP6V1H; BANF1; BTRC; CALM1; CALR; CANX; CBL; CBLL1; CCNK; CCNT1; CCNT2; CD4; CD9; CDH1; CDK7; CDK9; CHMP2A; CHMP2B; CHMP3; CHMP4A; CHMP4B; CHMP7; CLTA; CPSF4; CUL5; DNAJC3; DOCK2; EEF2; ELL; ELMO1"
"R-HSA-901042","Calnexin/calreticulin cycle",-0.253577150649431,0.0374270906504048,1.24208426381879e-11,16,"AMFR; CALR; CANX; EDEM2; EDEM3; GANAB; MAN1B1; MARCH6; PDIA3; RNF185; SYVN1; TRIM13; UBA52; UBC; UGGT1; UGGT2"
"R-HSA-1368082","RORA activates gene expression",-0.380171572091342,0.0563236653461907,1.48083592412322e-11,15,"CARM1; CHD9; CLOCK; CPT1A; HDAC3; NCOA1; NCOA6; NCOR1; NPAS2; NR1D1; RORA; RXRA; SIRT1; SMARCD3; TGS1"
"R-HSA-1538133","G0 and Early G1",0.301612291371628,0.0449109591891537,1.87057993812639e-11,16,"CCNA1; CCNA2; CDC25A; CDK2; E2F1; E2F5; HDAC1; LIN52; LIN54; LIN9; MAX; MYC; RBBP4; RBL1; RBL2; TFDP1"
"R-HSA-6811434","COPI-dependent Golgi-to-ER retrograde traffic",0.393219664851016,0.0585965786692138,1.9379257335022e-11,38,"ARF1; ARF3; ARF4; ARFGAP3; BNIP1; CENPE; COPA; COPE; COPG2; COPZ1; COPZ2; GBF1; KDELR1; KDELR2; KDELR3; KIF13B; KIF15; KIF16B; KIF19; KIF20B; KIF21A; KIF21B; KIF22; KIF27; KIF2A; KIF3B; KIF5A; KIF5C; KIF6; KIF9; KIFAP3; KIFC2; KLC1; KLC2; NAPA; NAPB; NAPG; NBAS"
"R-HSA-6782135","Dual incision in TC-NER",-0.142950795825215,0.0214325942713957,2.56178435872195e-11,39,"AQR; CDK7; CUL4A; ERCC1; ERCC2; ERCC3; ERCC4; ERCC5; ERCC6; ERCC8; GTF2H1; GTF2H2; GTF2H3; GTF2H4; ISY1; POLD2; POLD3; POLE; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L; PPIE; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3; UBA52; UBC; UVSSA; XAB2"
"R-HSA-2559585","Oncogene Induced Senescence",-0.204520099657812,0.0307433403254568,2.88154027118555e-11,15,"CDK6; CDKN2B; CDKN2C; E2F1; ERF; ID1; MAPK1; MAPK3; MDM2; MDM4; RB1; TFDP1; TP53; UBA52; UBC"
"R-HSA-1280215","Cytokine Signaling in Immune system",0.230599602211038,0.0349255466279497,4.03993891772571e-11,31,"AAAS; ABCE1; ADAM17; ADAR; AKT1; ALOX5; ANXA1; ANXA2; APP; ARF1; ATF1; BCL2; BCL6; BIRC2; BLNK; BRWD1; BTRC; CA1; CAMK2B; CAMK2D; CANX; CASP3; CBL; CCL2; CCR1; CD36; CD4; CD44; CDKN1A; CFL1; CIITA"
"R-HSA-157118","Signaling by NOTCH",0.236187015814087,0.0363649068313615,8.30797440673862e-11,26,"ADAM10; ADAM17; AGO2; ARRB1; ARRB2; ATP2A2; CDK8; CREB1; DLL4; E2F1; EGF; EGFR; FURIN; HDAC1; HDAC2; HDAC3; HDAC4; HDAC5; HES1; HEY2; HIF1A; JAG1; JUN; KAT2B; LFNG; MAML1"
"R-HSA-1655829","Regulation of cholesterol biosynthesis by SREBP (SREBF)",-0.277141748788654,0.0430085401107699,1.16459365583266e-10,33,"ACACA; ACACB; CARM1; CHD9; CYP51A1; DHCR7; FASN; FDPS; GGPS1; GPAM; HMGCS1; IDI1; INSIG2; LSS; MBTPS1; MVD; MVK; NCOA1; NCOA6; NFYB; NFYC; PMVK; RAN; RXRA; SAR1B; SCAP; SCD; SEC23A; SEC24C; SMARCD3; SQLE; TGS1; TM7SF2"
"R-HSA-199991","Membrane Trafficking",-0.177472908965631,0.0277410541863826,1.57959566996721e-10,41,"ACBD3; ACTR10; ACTR2; ADRB2; AGPAT3; AKT1; AKT2; AKT3; ALS2; ALS2CL; AMPH; ANK1; ANKRD27; ANKRD28; AP1B1; AP1M1; AP1S1; AP2A2; AP2B1; AP2M1; AP3B1; AP4B1; AP4E1; AP4S1; APOB; APP; ARF1; ARF3; ARF4; ARF6; ARFGAP3; ARFRP1; ARL1; ARPC1A; ARPC2; ARPC3; ARPC4; ARRB1; ARRB2; ASPSCR1; BET1"
"R-HSA-187037","NGF signalling via TRKA from the plasma membrane",0.163505615800245,0.0256335451522649,1.78737590661622e-10,43,"ADCYAP1; ADCYAP1R1; AP2A2; AP2B1; AP2M1; ATF1; CLTA; CREB1; CRK; CRKL; DNM2; DNM3; DUSP3; DUSP4; DUSP6; DUSP7; GRB2; KIDINS220; KRAS; MAP2K5; MAPK1; MAPK11; MAPK12; MAPK13; MAPK14; MAPK3; MEF2A; MEF2C; PIK3CA; PIK3CB; PIK3R1; PLCG1; PPP2CA; PPP2R1A; PPP2R1B; PPP2R5D; RALA; RALGDS; RAP1A; RIT1; RIT2; RPS6KA1; RPS6KA2"
"R-HSA-2424491","DAP12 signaling",0.282052774784617,0.0443102370998053,1.94770230843432e-10,13,"FYN; GRB2; HLA-E; KLRC2; KRAS; LCP2; PIK3CA; PIK3CB; PIK3R1; PLCG1; PLCG2; VAV2; VAV3"
"R-HSA-5653656","Vesicle-mediated transport",-0.175519668945629,0.0275953195560011,2.01115189346916e-10,40,"ACBD3; ACTR10; ACTR2; ADRB2; AGPAT3; AKT1; AKT2; AKT3; ALS2; ALS2CL; AMPH; ANK1; ANKRD27; ANKRD28; AP1B1; AP1M1; AP1S1; AP2A2; AP2B1; AP2M1; AP3B1; AP4B1; AP4E1; AP4S1; APOB; APOE; APP; ARF1; ARF3; ARF4; ARF6; ARFGAP3; ARFRP1; ARL1; ARPC1A; ARPC2; ARPC3; ARPC4; ARRB1; ARRB2"
"R-HSA-2426168","Activation of gene expression by SREBF (SREBP)",-0.280274683579744,0.0442660475886391,2.42639770436702e-10,26,"ACACA; ACACB; CARM1; CHD9; CYP51A1; DHCR7; FASN; FDPS; GGPS1; GPAM; HMGCS1; IDI1; LSS; MVD; MVK; NCOA1; NCOA6; NFYB; NFYC; PMVK; RXRA; SCD; SMARCD3; SQLE; TGS1; TM7SF2"
"R-HSA-166520","Signalling by NGF",-0.184780474673533,0.0293842637847317,3.20721517537788e-10,38,"AATF; ABR; ADAM17; ADCYAP1; ADCYAP1R1; AKAP13; AP2A2; AP2B1; AP2M1; ARHGEF1; ARHGEF10; ARHGEF10L; ARHGEF11; ARHGEF12; ARHGEF18; ARHGEF3; ARHGEF33; ARHGEF4; ARHGEF40; ATF1; BCL2L11; CASP3; CLTA; CREB1; CRK; CRKL; DNM2; DNM3; DUSP3; DUSP4; DUSP6; DUSP7; ECT2; FGD2; FGD3; FGD4; FURIN; GNA13"
"R-HSA-1251985","Nuclear signaling by ERBB4",-0.284363737645131,0.0452980374685118,3.43801166612968e-10,12,"ADAM17; BTC; ERBB4; ESR1; NCOR1; NRG2; NRG4; PSEN1; PSEN2; S100B; TAB2; WWOX"
"R-HSA-937041","IKK complex recruitment mediated by RIP1",-0.219546768565066,0.0349751992787333,3.44696172580702e-10,10,"BIRC2; CD14; SARM1; TICAM1; TLR4; TRAF6; UBA52; UBC; UBE2N; UBE2V1"
"R-HSA-180292","GAB1 signalosome",0.270692151732478,0.0435030349955946,4.89688166423855e-10,10,"EGF; EGFR; GAB1; GRB2; PAG1; PIK3CA; PIK3R1; PTPN11; PXN; SRC"
"R-HSA-532668","N-glycan trimming in the ER and Calnexin/Calreticulin cycle",-0.202613678520638,0.0329046725460382,7.38574950843956e-10,23,"AMFR; CALR; CANX; DERL1; EDEM2; EDEM3; ENGASE; GANAB; MAN1B1; MARCH6; MLEC; MOGS; PDIA3; PSMC1; RAD23B; RNF185; SYVN1; TRIM13; UBA52; UBC; UBXN1; UGGT1; UGGT2"
"R-HSA-1839126","FGFR2 mutant receptor activation",-0.166922796329306,0.0271874888496252,8.26818540942558e-10,17,"FGF1; FGF10; FGF17; FGF5; FGF9; FGFR2; GTF2F2; NCBP1; NCBP2; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L"
"R-HSA-2032785","YAP1- and WWTR1 (TAZ)-stimulated gene expression",-0.333055193736562,0.054418742818136,9.34406942298037e-10,11,"CARM1; CHD9; KAT2B; NCOA1; NCOA6; RUNX2; RXRA; SMARCD3; TEAD1; TEAD2; TGS1"
"R-HSA-201681","TCF dependent signaling in response to WNT",0.178633197927897,0.0293295250281709,1.12517219212732e-09,33,"AKT1; AKT2; ASH2L; AXIN1; BTRC; CAV1; CBY1; CCDC88C; CSNK2A2; CTNNBIP1; CUL3; DACT1; DKK1; DVL1; DVL2; FRAT1; FRAT2; FZD1; FZD6; FZD8; GSK3B; H2AFV; H2AFZ; H3F3A; HDAC1; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN"
"R-HSA-2990846","SUMOylation",0.186473848759894,0.0308389271009312,1.4783945648368e-09,34,"AAAS; BLM; CBX4; EID3; HDAC1; HDAC2; HDAC4; HIC1; HNRNPK; INCENP; L3MBTL2; MDC1; MDM2; MITF; NDC1; NOP58; NSMCE1; NSMCE2; NSMCE4A; NUP107; NUP205; NUP214; NUP35; NUP37; NUP43; NUP50; NUP54; NUP62; NUP85; NUP88; NUP93; PARP1; PHC2; PIAS2"
"R-HSA-3108232","SUMO E3 ligases SUMOylate target proteins",0.186473848759894,0.0308389271009312,1.4783945648368e-09,34,"AAAS; BLM; CBX4; EID3; HDAC1; HDAC2; HDAC4; HIC1; HNRNPK; INCENP; L3MBTL2; MDC1; MDM2; MITF; NDC1; NOP58; NSMCE1; NSMCE2; NSMCE4A; NUP107; NUP205; NUP214; NUP35; NUP37; NUP43; NUP50; NUP54; NUP62; NUP85; NUP88; NUP93; PARP1; PHC2; PIAS2"
"R-HSA-8856828","Clathrin-mediated endocytosis",-0.177547946496939,0.0295020643829203,1.76418068479128e-09,34,"ACTR2; ADRB2; AMPH; AP2A2; AP2B1; AP2M1; APOB; ARF6; ARPC1A; ARPC2; ARPC3; ARPC4; ARRB1; ARRB2; CBL; CD4; CFTR; CLTA; CLTCL1; COPS2; COPS3; COPS6; COPS7A; DAB2; DNAJC6; DNM2; DNM3; DVL2; EGF; EGFR; EPN2; EPS15; FCHO1; GRB2"
"R-HSA-3928665","EPH-ephrin mediated repulsion of cells",-0.20833322498373,0.0347648433205411,2.06460307928817e-09,27,"ADAM10; AP2A2; AP2B1; AP2M1; CLTA; CLTCL1; EFNA3; EFNA5; EFNB2; EFNB3; EPHA10; EPHA2; EPHA3; EPHA5; EPHA7; EPHB1; EPHB2; EPHB4; FYN; LYN; MMP2; PSEN1; PSEN2; SRC; VAV2; VAV3; YES1"
"R-HSA-5637810","Constitutive Signaling by EGFRvIII",0.240471513278551,0.040270337015215,2.35182440572369e-09,11,"CBL; CDC37; EGF; EGFR; GAB1; GRB2; HSP90AA1; KRAS; PIK3CA; PIK3R1; PLCG1"
"R-HSA-5637812","Signaling by EGFRvIII in Cancer",0.240471513278551,0.040270337015215,2.35182440572369e-09,11,"CBL; CDC37; EGF; EGFR; GAB1; GRB2; HSP90AA1; KRAS; PIK3CA; PIK3R1; PLCG1"
"R-HSA-382551","Transport of small molecules",-0.23813045689666,0.0398901934732617,2.37764416898306e-09,34,"A2M; ABCA1; ABCA10; ABCA4; ABCA5; ABCA6; ABCA7; ABCA8; ABCA9; ABCB10; ABCB8; ABCB9; ABCC1; ABCC10; ABCC4; ABCC5; ABCC8; ABCC9; ABCG1; ACO1; ADCY3; ADCY6; ADCY7; ADD1; ADD2; AKAP1; ALAD; ANGPTL3; ANGPTL4; ANKH; ANO10; ANO2; ANO3; ANO5"
"R-HSA-1362277","Transcription of E2F targets under negative control by DREAM complex",0.337626047771075,0.0567480836996122,2.68866617968472e-09,13,"CDC25A; E2F1; E2F5; HDAC1; LIN52; LIN54; LIN9; MAX; MYC; RBBP4; RBL1; RBL2; TFDP1"
"R-HSA-983169","Class I MHC mediated antigen processing & presentation",0.30052784121284,0.0505689482847765,2.7996791152513e-09,29,"ANAPC13; ANAPC4; ANAPC5; AREL1; ASB1; ASB13; ASB14; ASB2; ASB4; ASB5; ASB6; ATG7; BLMH; BTBD1; BTRC; CALR; CANX; CD14; CD36; CDC16; CTSS; CUL3; CUL5; CUL7; DET1; DTX3L; DZIP3; ERAP1; ERAP2"
"R-HSA-70171","Glycolysis",0.167611443838464,0.0282584667836529,3.00415965227084e-09,40,"AAAS; ADPGK; ALDOB; ALDOC; BPGM; ENO1; ENO3; GNPDA1; GNPDA2; HK1; NDC1; NUP107; NUP205; NUP214; NUP35; NUP37; NUP43; NUP50; NUP54; NUP62; NUP85; NUP88; NUP93; PFKFB2; PFKFB4; PFKL; PFKP; PGAM1; PGM2L1; PGP; PKM; POM121; POM121C; PPP2CA; PPP2R1A; PPP2R1B; PPP2R5D; PRKACA; RAE1; RANBP2"
"R-HSA-5260271","Diseases of Immune System",0.374376799515405,0.0631472915805188,3.05476287021844e-09,13,"CD14; CD36; NFKB1; NFKBIA; NFKBIB; RELA; TICAM1; TIRAP; TLR1; TLR10; TLR4; TLR5; TLR6"
"R-HSA-5602358","Diseases associated with the TLR signaling cascade",0.374376799515405,0.0631472915805188,3.05476287021844e-09,13,"CD14; CD36; NFKB1; NFKBIA; NFKBIB; RELA; TICAM1; TIRAP; TLR1; TLR10; TLR4; TLR5; TLR6"
"R-HSA-195253","Degradation of beta-catenin by the destruction complex",0.120790486964155,0.0204062350928023,3.23328267394131e-09,35,"AXIN1; BTRC; CTBP2; FRAT1; FRAT2; GSK3B; HDAC1; MYC; PPP2CA; PPP2R1A; PPP2R1B; PPP2R5A; PPP2R5C; PPP2R5D; PPP2R5E; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2"
"R-HSA-5250941","Negative epigenetic regulation of rRNA expression",0.149555199512937,0.0253465315212484,3.6257583381695e-09,40,"ARID4B; CD3EAP; CDK7; DNMT3B; ERCC2; ERCC3; GTF2H1; GTF2H2; GTF2H3; GTF2H4; H2AFV; H2AFZ; H3F3A; HDAC1; HDAC2; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; POLR1A; POLR1B; POLR1C; POLR1D; POLR1E; POLR2E; POLR2H; POLR2K; POLR2L; RRP8; SAP130; SAP18; SAP30; SAP30BP; SAP30L; SIN3B; SIRT1"
"R-HSA-193368","Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol",-0.269605557569091,0.0457919079816086,3.91786107688768e-09,15,"ACOT8; ACOX2; AKR1C1; AKR1C2; AKR1C3; AMACR; BAAT; CYP7B1; HSD17B4; HSD3B7; NCOA1; RXRA; SCP2; SLC27A2; SLC27A5"
"R-HSA-6802946","Signaling by moderate kinase activity BRAF mutants",0.246180871822768,0.0419205508989791,4.2912117174259e-09,16,"ARRB1; ARRB2; IQGAP1; ITGB3; JAK2; KRAS; KSR1; KSR2; MAPK1; MAPK3; PEBP1; RAP1A; SRC; TLN1; VCL; VWF"
"R-HSA-6802955","Paradoxical activation of RAF signaling by kinase inactive BRAF",0.246180871822768,0.0419205508989791,4.2912117174259e-09,16,"ARRB1; ARRB2; IQGAP1; ITGB3; JAK2; KRAS; KSR1; KSR2; MAPK1; MAPK3; PEBP1; RAP1A; SRC; TLN1; VCL; VWF"
"R-HSA-201722","Formation of the beta-catenin:TCF transactivating complex",0.204089009892749,0.034874244234197,4.85283646570981e-09,23,"ASH2L; H2AFV; H2AFZ; H3F3A; HDAC1; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; KMT2D; LEO1; MYC; PYGO2; RBBP5; RUVBL1; SMARCA4; TLE3; TLE4; TRRAP"
"R-HSA-162599","Late Phase of HIV Life Cycle",0.155778728393197,0.0266739288758351,5.21657843517179e-09,42,"AAAS; CCNK; CCNT1; CCNT2; CDK7; CDK9; CHMP2A; CHMP2B; CHMP3; CHMP4A; CHMP4B; CHMP7; ELL; ERCC2; ERCC3; FURIN; GTF2A1; GTF2A2; GTF2E1; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; MVB12A; MVB12B; NCBP1; NCBP2; NDC1; NELFA; NELFB; NELFCD; NMT1; NMT2; NUP107; NUP205; NUP214; NUP35; NUP37; NUP43; NUP50; NUP54"
"R-HSA-5635838","Activation of SMO",-0.26951276123619,0.0467347679907753,8.0763141449533e-09,11,"ARRB1; ARRB2; BOC; CDON; EFCAB7; EVC2; GAS1; GAS8; IQCE; PTCH1; SMO"
"R-HSA-6802949","Signaling by RAS mutants",0.233117250476055,0.0404798002685385,8.4687023728408e-09,25,"ARRB1; ARRB2; IQGAP1; ITGB3; JAK2; KRAS; KSR1; KSR2; MAPK1; MAPK3; NF1; PEBP1; RAP1A; RASA1; RASA2; RASA3; RASA4; RASAL1; RASAL2; RASAL3; SPRED2; SRC; TLN1; VCL; VWF"
"R-HSA-74160","Gene expression (Transcription)",0.203909069515609,0.035422963083054,8.59219789381007e-09,30,"AAAS; ACTB; ACTL6A; ACTL6B; AEBP2; AFF4; AGO2; AIFM2; AKT1; AKT2; AKT3; APOE; ARID1A; ARID3A; ARID4B; ASH2L; ATAD2; ATM; ATRIP; AXIN1; BARD1; BCL2L11; BCL6; BID; BLM; BMP2; BRD7; BRF1; BRIP1; BRPF1"
"R-HSA-73762","RNA Polymerase I Transcription Initiation",0.177711395320153,0.0310759162530607,1.07391865960563e-08,33,"CD3EAP; CDK7; ERCC2; ERCC3; ERCC6; GATAD2A; GTF2H1; GTF2H2; GTF2H3; GTF2H4; HDAC1; HDAC2; KAT2B; MBD3; MTA3; POLR1A; POLR1B; POLR1C; POLR1D; POLR1E; POLR2E; POLR2H; POLR2K; POLR2L; RBBP4; RRN3; TAF1A; TAF1B; TAF1C; TAF1D; TTF1; UBTF; ZNRD1"
"R-HSA-192105","Synthesis of bile acids and bile salts",-0.252711340951207,0.0443027862357395,1.16900249682053e-08,20,"ACOT8; ACOX2; AKR1C1; AKR1C2; AKR1C3; AMACR; BAAT; CYP39A1; CYP7B1; HSD17B4; HSD3B7; NCOA1; OSBP; OSBPL1A; OSBPL6; OSBPL9; RXRA; SCP2; SLC27A2; SLC27A5"
"R-HSA-6781823","Formation of TC-NER Pre-Incision Complex",-0.135186990749275,0.0238168334994811,1.37791381269401e-08,29,"AQR; CDK7; COPS2; COPS3; COPS6; COPS7A; CUL4A; ERCC2; ERCC3; ERCC6; ERCC8; GTF2H1; GTF2H2; GTF2H3; GTF2H4; ISY1; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L; PPIE; UBA52; UBC; UVSSA; XAB2"
"R-HSA-6798695","Neutrophil degranulation",-0.216906305880068,0.0384795534935339,1.73114797836465e-08,33,"ACLY; ACTR10; ACTR1B; ACTR2; ADAM10; ADAM8; AGA; AGL; ALAD; ALDOC; ALOX5; AMPD3; ANXA2; AP1M1; AP2A2; APRT; ARHGAP9; ARMC8; ARSA; ARSB; ASAH1; ATAD3B; ATG7; ATP11A; ATP11B; ATP6V0C; ATP8A1; ATP8B4; BIN2; C6orf120; CAB39; CAND1; CANT1"
"R-HSA-427413","NoRC negatively regulates rRNA expression",0.142552032824005,0.0253704054570433,1.92253258638914e-08,39,"ARID4B; CD3EAP; CDK7; DNMT3B; ERCC2; ERCC3; GTF2H1; GTF2H2; GTF2H3; GTF2H4; H2AFV; H2AFZ; H3F3A; HDAC1; HDAC2; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; POLR1A; POLR1B; POLR1C; POLR1D; POLR1E; POLR2E; POLR2H; POLR2K; POLR2L; SAP130; SAP18; SAP30; SAP30BP; SAP30L; SIN3B; SUDS3"
"R-HSA-5601884","PIWI-interacting RNA (piRNA) biogenesis",-0.177217025697745,0.0315740150226149,1.99137191762734e-08,18,"HENMT1; HSP90AA1; MAEL; MOV10L1; MYBL1; PIWIL2; PIWIL4; PLD6; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L; TDRD6; TDRD9"
"R-HSA-449147","Signaling by Interleukins",0.209538547745949,0.0374372985853315,2.18025957845768e-08,28,"AKT1; ALOX5; ANXA1; ANXA2; APP; ARF1; ATF1; BCL2; BCL6; BLNK; BRWD1; BTRC; CA1; CANX; CASP3; CBL; CCL2; CCR1; CD36; CD4; CDKN1A; CFL1; CNN2; CREB1; CRK; CRKL; CRLF1; CSF1"
"R-HSA-72649","Translation initiation complex formation",-0.210593702963368,0.0377277953617651,2.37871725075562e-08,33,"EIF2S1; EIF3A; EIF3B; EIF3C; EIF3E; EIF3F; EIF3H; EIF3I; EIF3L; EIF4A1; EIF4A2; EIF4B; EIF4E; RPS12; RPS13; RPS14; RPS15; RPS19; RPS2; RPS20; RPS23; RPS24; RPS25; RPS26; RPS27; RPS27L; RPS28; RPS3; RPS5; RPS7; RPS8; RPS9; RPSA"
"R-HSA-72702","Ribosomal scanning and start codon recognition",-0.210593702963368,0.0377277953617651,2.37871725075562e-08,33,"EIF2S1; EIF3A; EIF3B; EIF3C; EIF3E; EIF3F; EIF3H; EIF3I; EIF3L; EIF4A1; EIF4A2; EIF4B; EIF4E; RPS12; RPS13; RPS14; RPS15; RPS19; RPS2; RPS20; RPS23; RPS24; RPS25; RPS26; RPS27; RPS27L; RPS28; RPS3; RPS5; RPS7; RPS8; RPS9; RPSA"
"R-HSA-2555396","Mitotic Metaphase and Anaphase",-0.187424908899958,0.0335800643289385,2.38543732516036e-08,26,"ANAPC16; ANAPC4; ANAPC5; ANKLE2; BANF1; BUB3; CDC16; CENPC; CENPE; CENPH; CENPL; CENPN; CENPP; CENPQ; CENPT; CKAP5; CLIP1; DSN1; DYNC1H1; DYNC1LI2; DYNLL2; INCENP; ITGB3BP; KIF2A; LEMD2; LEMD3"
"R-HSA-68882","Mitotic Anaphase",-0.187424908899958,0.0335800643289385,2.38543732516036e-08,26,"ANAPC16; ANAPC4; ANAPC5; ANKLE2; BANF1; BUB3; CDC16; CENPC; CENPE; CENPH; CENPL; CENPN; CENPP; CENPQ; CENPT; CKAP5; CLIP1; DSN1; DYNC1H1; DYNC1LI2; DYNLL2; INCENP; ITGB3BP; KIF2A; LEMD2; LEMD3"
"R-HSA-9006934","Signaling by Receptor Tyrosine Kinases",-0.161496916399024,0.0289590055116407,2.45064226612204e-08,37,"AATF; ABI2; ABR; ADAM10; ADAM17; ADCYAP1; ADCYAP1R1; AHCYL1; AKAP13; AKT1; AKT2; AKT3; AP2A2; AP2B1; AP2M1; ARF6; ARHGEF1; ARHGEF10; ARHGEF10L; ARHGEF11; ARHGEF12; ARHGEF18; ARHGEF3; ARHGEF33; ARHGEF4; ARHGEF40; ATF1; ATP6V0A2; ATP6V0B; ATP6V0C; ATP6V0D1; ATP6V0E1; ATP6V0E2; ATP6V1C1; ATP6V1C2; ATP6V1E1; ATP6V1E2"
"R-HSA-5693567","HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)",0.167294217589741,0.0300211085400588,2.51033126788244e-08,31,"ATM; ATRIP; BARD1; BLM; BRCA2; BRIP1; CCNA1; CCNA2; CDK2; CHEK1; DNA2; EME2; ERCC1; ERCC4; EXO1; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; MDC1; NBN; PALB2; POLD2; POLD3; POLE; POLH; PPP4C; RAD1; RAD50"
"R-HSA-194068","Bile acid and bile salt metabolism",-0.245263115869823,0.0440191651334821,2.52215096434959e-08,22,"ACOT8; ACOX2; AKR1C1; AKR1C2; AKR1C3; AMACR; BAAT; CYP39A1; CYP7B1; HSD17B4; HSD3B7; NCOA1; OSBP; OSBPL1A; OSBPL6; OSBPL9; RXRA; SCP2; SLC27A2; SLC27A5; SLCO1A2; STARD5"
"R-HSA-1268020","Mitochondrial protein import",-0.27770923781057,0.0502716969374443,3.31052898051331e-08,31,"BCS1L; CHCHD2; CHCHD4; CHCHD5; CHCHD7; CMC2; COA6; COX17; DNAJC19; FXN; GRPEL1; GRPEL2; HSPA9; HSPD1; MTX1; MTX2; PAM16; PITRM1; SAMM50; SLC25A12; SLC25A13; TIMM10; TIMM13; TIMM22; TIMM44; TIMM8B; TIMM9; TOMM22; TOMM40; TOMM7; VDAC1"
"R-HSA-427389","ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression",0.1875639066512,0.0342234971443153,4.23983300213869e-08,20,"CBX3; ERCC6; GATAD2A; H2AFV; H2AFZ; H3F3A; HDAC1; HDAC2; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; MBD3; MTA3; RBBP4; TTF1"
"R-HSA-1980145","Signaling by NOTCH2",-0.177724346180391,0.0324649215506832,4.39120190643651e-08,13,"ADAM10; CREB1; DLL4; HES1; JAG1; MAML1; MDK; MIB1; PSEN1; PSEN2; RBPJ; UBA52; UBC"
"R-HSA-983231","Factors involved in megakaryocyte development and platelet production",0.28847916463475,0.0527009830098806,4.40272752635555e-08,25,"AK3; AKAP1; AKAP10; CABLES1; CABLES2; CAPZA2; CAPZB; CDK2; CDK5; CENPE; DOCK1; DOCK2; DOCK4; DOCK7; DOCK8; EHD1; EHD2; EHD3; H3F3A; HDAC1; HDAC2; HMG20B; IRF2; JAK2; JMJD1C"
"R-HSA-1989781","PPARA activates gene expression",-0.213690683871706,0.0395751997517084,6.67855519237639e-08,32,"ABCA1; ACADM; ACSL1; AGT; ANGPTL4; ARNT; ARNT2; CARM1; CD36; CDK8; CHD9; CLOCK; CPT1A; CPT2; FADS1; FAM120B; FHL2; G0S2; GLIPR1; GRHL1; HDAC3; HMGCS1; MED10; MED13; MED16; MED17; MED19; MED20; MED23; MED24; MED27; MED28"
"R-HSA-400206","Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)",-0.213690683871706,0.0395751997517084,6.67855519237639e-08,32,"ABCA1; ACADM; ACSL1; AGT; ANGPTL4; ARNT; ARNT2; CARM1; CD36; CDK8; CHD9; CLOCK; CPT1A; CPT2; FADS1; FAM120B; FHL2; G0S2; GLIPR1; GRHL1; HDAC3; HMGCS1; MED10; MED13; MED16; MED17; MED19; MED20; MED23; MED24; MED27; MED28"
"R-HSA-111996","Ca-dependent events",-0.178067936072873,0.0332093647998874,8.23148450607926e-08,15,"ADCY3; ADCY6; ADCY7; CALM1; CAMK4; CREB1; MAPK1; PDE1B; PDE1C; PRKACA; PRKAR1A; PRKAR1B; PRKAR2A; PRKCA; PRKCD"
"R-HSA-3858494","Beta-catenin independent WNT signaling",-0.149058189707645,0.0279031254712444,9.19322281399613e-08,34,"AGO2; AP2A2; AP2B1; AP2M1; ARRB2; CALM1; CLTA; DAAM1; DVL1; DVL2; FZD1; FZD3; FZD6; FZD8; GNAO1; GNB2; GNB3; GNB4; GNB5; GNG11; GNG4; GNG5; GNG7; ITPR2; ITPR3; MAP3K7; MYC; NFATC1; NLK; PARD6A; PFN1; PLCB1; PLCB3; PPP3CB"
"R-HSA-72662","Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S",-0.200550506508169,0.0375812443414043,9.47829489966504e-08,34,"EIF2S1; EIF3A; EIF3B; EIF3C; EIF3E; EIF3F; EIF3H; EIF3I; EIF3L; EIF4A1; EIF4A2; EIF4B; EIF4E; EIF4EBP1; RPS12; RPS13; RPS14; RPS15; RPS19; RPS2; RPS20; RPS23; RPS24; RPS25; RPS26; RPS27; RPS27L; RPS28; RPS3; RPS5; RPS7; RPS8; RPS9; RPSA"
"R-HSA-5696400","Dual Incision in GG-NER",-0.134197433493572,0.0253287396904887,1.16932010350292e-07,26,"CHD1L; CUL4A; ERCC1; ERCC2; ERCC3; ERCC4; ERCC5; GTF2H1; GTF2H2; GTF2H3; GTF2H4; PARP1; PARP2; POLD2; POLD3; POLE; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3; UBA52; UBC"
"R-HSA-5250913","Positive epigenetic regulation of rRNA expression",0.143986265638075,0.0271827242376326,1.17735504984801e-07,35,"ACTB; CBX3; CD3EAP; DEK; ERCC6; GATAD2A; GSK3B; H2AFV; H2AFZ; H3F3A; HDAC1; HDAC2; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; KAT2B; MBD3; MTA3; MYBBP1A; POLR1A; POLR1B; POLR1C; POLR1D; POLR1E; POLR2E; POLR2H; POLR2K; POLR2L; RBBP4; SF3B1"
"R-HSA-176187","Activation of ATR in response to replication stress",-0.161778373767785,0.0306637371336873,1.32116383728007e-07,24,"ATRIP; CDC25A; CDC7; CDK2; CHEK1; DBF4; MCM2; MCM3; MCM4; MCM6; MCM7; MCM8; ORC2; ORC4; ORC5; RAD1; RAD9A; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3"
"R-HSA-1280218","Adaptive Immune System",-0.156971507872831,0.0298156570007561,1.40392357585542e-07,34,"ACTR10; ACTR1B; AHCYL1; AKT1; AKT2; AKT3; ANAPC13; ANAPC4; ANAPC5; AP1B1; AP1M1; AP1S1; AP2A2; AP2B1; AP2M1; AREL1; ARF1; ASB1; ASB13; ASB14; ASB2; ASB4; ASB5; ASB6; ATG7; BLMH; BLNK; BTBD1; BTN2A1; BTN2A2; BTN3A2; BTN3A3; BTNL9; BTRC"
"R-HSA-380320","Recruitment of NuMA to mitotic centrosomes",0.188518863418168,0.0358837754579016,1.49157777476249e-07,42,"ALMS1; CDK5RAP2; CENPJ; CEP135; CEP164; CEP192; CEP250; CEP290; CEP41; CEP57; CEP63; CEP72; CEP76; CKAP5; CNTRL; CSNK1D; DCTN3; DYNC1H1; HAUS1; HAUS2; HAUS4; HAUS5; HSP90AA1; MAPRE1; MZT2A; MZT2B; NDE1; NEDD1; NEK2; NINL; ODF2; PAFAH1B1; PCM1; PCNT; PLK1; PLK4; PPP2R1A; PRKACA; SFI1; SSNA1; TUBA1A; TUBA4A"
"R-HSA-8854518","AURKA Activation by TPX2",0.188017149512205,0.0359396006588457,1.68162093184604e-07,42,"ALMS1; CDK5RAP2; CENPJ; CEP135; CEP164; CEP192; CEP250; CEP290; CEP41; CEP57; CEP63; CEP72; CEP76; CKAP5; CNTRL; CSNK1D; DCTN3; DYNC1H1; HAUS1; HAUS2; HAUS4; HAUS5; HMMR; HSP90AA1; MAPRE1; NDE1; NEDD1; NEK2; NINL; ODF2; PAFAH1B1; PCM1; PCNT; PLK1; PLK4; PPP2R1A; PRKACA; SFI1; SSNA1; TPX2; TUBA1A; TUBA4A"
"R-HSA-429914","Deadenylation-dependent mRNA decay",-0.206482466349562,0.0395280970382909,1.75393729754517e-07,35,"CNOT11; CNOT2; CNOT4; CNOT6L; CNOT7; CNOT8; DCP1A; DCP1B; DCP2; DCPS; DDX6; EDC3; EIF4A1; EIF4A2; EIF4B; EIF4E; EXOSC2; EXOSC3; EXOSC4; EXOSC5; EXOSC6; EXOSC8; EXOSC9; HBS1L; LSM5; LSM6; LSM7; NT5C3B; PAIP1; PAN2; PAN3; PARN; PATL1; TNKS1BP1; TTC37"
"R-HSA-5687128","MAPK6/MAPK4 signaling",-0.113645616349814,0.0217929067133961,1.84017196559803e-07,31,"AGO2; CCND3; CDC14A; CDC14B; CDC42EP2; CDC42EP3; FOXO1; JUN; KALRN; MAPK4; MAPKAPK5; MMP2; MYC; NCOA3; PAK1; PAK2; PRKACA; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13"
"R-HSA-380270","Recruitment of mitotic centrosome proteins and complexes",0.18521169166297,0.0356061078216847,1.97491699502554e-07,44,"ALMS1; CDK11A; CDK11B; CDK5RAP2; CENPJ; CEP135; CEP164; CEP192; CEP250; CEP290; CEP41; CEP57; CEP63; CEP72; CEP76; CKAP5; CNTRL; CSNK1D; DCTN3; DYNC1H1; HAUS1; HAUS2; HAUS4; HAUS5; HSP90AA1; MAPRE1; MZT2A; MZT2B; NDE1; NEDD1; NEK2; NINL; ODF2; PAFAH1B1; PCM1; PCNT; PLK1; PLK4; PPP2R1A; PRKACA; SFI1; SSNA1; TUBA1A; TUBA4A"
"R-HSA-380287","Centrosome maturation",0.18521169166297,0.0356061078216847,1.97491699502554e-07,44,"ALMS1; CDK11A; CDK11B; CDK5RAP2; CENPJ; CEP135; CEP164; CEP192; CEP250; CEP290; CEP41; CEP57; CEP63; CEP72; CEP76; CKAP5; CNTRL; CSNK1D; DCTN3; DYNC1H1; HAUS1; HAUS2; HAUS4; HAUS5; HSP90AA1; MAPRE1; MZT2A; MZT2B; NDE1; NEDD1; NEK2; NINL; ODF2; PAFAH1B1; PCM1; PCNT; PLK1; PLK4; PPP2R1A; PRKACA; SFI1; SSNA1; TUBA1A; TUBA4A"
"R-HSA-5693616","Presynaptic phase of homologous DNA pairing and strand exchange",-0.155765155161354,0.0300361078114923,2.14939438203248e-07,28,"ATM; ATRIP; BARD1; BLM; BRCA2; BRIP1; CHEK1; DNA2; EXO1; NBN; RAD1; RAD50; RAD51B; RAD51C; RAD9A; RFC2; RFC3; RFC4; RFC5; RMI1; RMI2; RPA1; RPA2; RPA3; TOP3A; TOPBP1; WRN; XRCC2"
"R-HSA-429947","Deadenylation of mRNA",-0.237724894857016,0.0459870150196898,2.34857156934376e-07,15,"CNOT11; CNOT2; CNOT4; CNOT6L; CNOT7; CNOT8; EIF4A1; EIF4A2; EIF4B; EIF4E; PAIP1; PAN2; PAN3; PARN; TNKS1BP1"
"R-HSA-202424","Downstream TCR signaling",-0.108335413171535,0.0209645155167985,2.3716854870853e-07,26,"BTRC; CARD11; CD4; INPP5D; MALT1; MAP3K7; NFKB1; NFKBIA; PIK3CA; PIK3CB; PIK3R1; PRKCQ; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13"
"R-HSA-69278","Cell Cycle, Mitotic",0.156162323635456,0.0303302081176767,2.62243567409335e-07,33,"AAAS; AJUBA; AKT1; AKT2; AKT3; ALMS1; ANAPC16; ANAPC4; ANAPC5; ANKLE2; ARPP19; BANF1; BLZF1; BORA; BTRC; BUB3; CCNA1; CCNA2; CCND2; CCND3; CDC14A; CDC16; CDC25A; CDC25B; CDC7; CDK11A; CDK11B; CDK2; CDK5RAP2; CDK6; CDK7; CDKN1A; CDKN1B"
"R-HSA-6781827","Transcription-Coupled Nucleotide Excision Repair (TC-NER)",-0.116286744526182,0.02266324791869,2.88097505398849e-07,42,"AQR; CDK7; COPS2; COPS3; COPS6; COPS7A; CUL4A; ELL; ERCC1; ERCC2; ERCC3; ERCC4; ERCC5; ERCC6; ERCC8; GTF2H1; GTF2H2; GTF2H3; GTF2H4; ISY1; LIG1; LIG3; POLD2; POLD3; POLE; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L; PPIE; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3"
"R-HSA-5693538","Homology Directed Repair",0.151406995809413,0.0296080081135203,3.15879287239098e-07,33,"ATM; ATRIP; BARD1; BLM; BRCA2; BRIP1; CCNA1; CCNA2; CDK2; CHEK1; DNA2; EME2; ERCC1; ERCC4; EXO1; FEN1; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; LIG3; MDC1; NBN; PALB2; PARP1; PARP2; POLD2; POLD3; POLE; POLH; POLQ"
"R-HSA-390471","Association of TriC/CCT with target proteins during biosynthesis",-0.216656236878322,0.0426032713982793,3.66781285691996e-07,20,"AP3M1; ARFGEF2; CCT3; CCT4; CCT5; CCT6B; CCT8; DCAF7; FBXO6; FBXW2; FBXW9; FKBP9; HDAC3; KIF13A; KIFC3; LONP2; NOP56; SPHK1; STAT3; TP53"
"R-HSA-5685938","HDR through Single Strand Annealing (SSA)",-0.155624784033642,0.0306169333935412,3.7158926798919e-07,26,"ATM; ATRIP; BARD1; BLM; BRIP1; DNA2; ERCC1; ERCC4; EXO1; NBN; RAD1; RAD50; RAD52; RAD9A; RFC2; RFC3; RFC4; RFC5; RMI1; RMI2; RPA1; RPA2; RPA3; TOP3A; TOPBP1; WRN"
"R-HSA-194315","Signaling by Rho GTPases",0.283840880564839,0.055847808486216,3.72696279718963e-07,39,"A2M; ABI2; ABR; ACTB; ACTG1; ACTR2; AKAP13; ARAP1; ARAP2; ARAP3; ARHGAP1; ARHGAP11A; ARHGAP12; ARHGAP15; ARHGAP18; ARHGAP19; ARHGAP20; ARHGAP21; ARHGAP22; ARHGAP24; ARHGAP25; ARHGAP26; ARHGAP27; ARHGAP28; ARHGAP29; ARHGAP30; ARHGAP31; ARHGAP32; ARHGAP39; ARHGAP42; ARHGAP9; ARHGEF1; ARHGEF10; ARHGEF10L; ARHGEF11; ARHGEF12; ARHGEF18; ARHGEF3; ARHGEF33"
"R-HSA-70326","Glucose metabolism",0.174326629289383,0.034408633908067,4.05488363505779e-07,35,"AAAS; ADPGK; ALDOB; ALDOC; BPGM; ENO1; ENO3; G6PC3; GNPDA1; GNPDA2; GOT2; HK1; MDH2; NDC1; NUP107; NUP205; NUP214; NUP35; NUP37; NUP43; NUP50; NUP54; NUP62; NUP85; NUP88; NUP93; PCK2; PFKFB2; PFKFB4; PFKL; PFKP; PGAM1; PGM2L1; PGP; PKM"
"R-HSA-442742","CREB phosphorylation through the activation of Ras",-0.190567179983886,0.0376719163237086,4.22344334419061e-07,11,"CALM1; CAMK2B; CAMK2D; CREB1; GRIN2A; GRIN2D; MAPK1; NEFL; RASGRF2; RPS6KA1; RPS6KA2"
"R-HSA-438064","Post NMDA receptor activation events",-0.177491712659057,0.0351015802010398,4.26984377141149e-07,14,"ADCY3; CALM1; CAMK2B; CAMK2D; CAMK4; CREB1; GRIN2A; GRIN2D; MAPK1; NEFL; PRKACA; RASGRF2; RPS6KA1; RPS6KA2"
"R-HSA-204998","Cell death signalling via NRAGE, NRIF and NADE",-0.183082778196694,0.0364779034666442,5.19398106919536e-07,35,"AATF; ABR; AKAP13; ARHGEF1; ARHGEF10; ARHGEF10L; ARHGEF11; ARHGEF12; ARHGEF18; ARHGEF3; ARHGEF33; ARHGEF4; ARHGEF40; BCL2L11; CASP3; ECT2; FGD2; FGD3; FGD4; GNA13; ITGB3BP; ITSN1; KALRN; MAPK8; MCF2L; OBSCN; PLEKHG2; PLEKHG5; PREX1; PSEN1; PSEN2; RASGRF2; SOS2; TIAM2; TRAF6"
"R-HSA-442755","Activation of NMDA receptor and postsynaptic events",-0.175096556861401,0.0349491459682815,5.4419228387165e-07,15,"ADCY3; CALM1; CAMK2B; CAMK2D; CAMK4; CREB1; GRIA1; GRIN2A; GRIN2D; MAPK1; NEFL; PRKACA; RASGRF2; RPS6KA1; RPS6KA2"
"R-HSA-380259","Loss of Nlp from mitotic centrosomes",0.178780440373699,0.0357397042052845,5.66526604830899e-07,41,"ALMS1; CDK5RAP2; CENPJ; CEP135; CEP164; CEP192; CEP250; CEP290; CEP41; CEP57; CEP63; CEP72; CEP76; CKAP5; CNTRL; CSNK1D; DCTN3; DYNC1H1; HAUS1; HAUS2; HAUS4; HAUS5; HSP90AA1; MAPRE1; NDE1; NEDD1; NEK2; NINL; ODF2; PAFAH1B1; PCM1; PCNT; PLK1; PLK4; PPP2R1A; PRKACA; SFI1; SSNA1; TUBA1A; TUBA4A; YWHAE"
"R-HSA-380284","Loss of proteins required for interphase microtubule organization from the centrosome",0.178780440373699,0.0357397042052845,5.66526604830899e-07,41,"ALMS1; CDK5RAP2; CENPJ; CEP135; CEP164; CEP192; CEP250; CEP290; CEP41; CEP57; CEP63; CEP72; CEP76; CKAP5; CNTRL; CSNK1D; DCTN3; DYNC1H1; HAUS1; HAUS2; HAUS4; HAUS5; HSP90AA1; MAPRE1; NDE1; NEDD1; NEK2; NINL; ODF2; PAFAH1B1; PCM1; PCNT; PLK1; PLK4; PPP2R1A; PRKACA; SFI1; SSNA1; TUBA1A; TUBA4A; YWHAE"
"R-HSA-167238","Pausing and recovery of Tat-mediated HIV elongation",-0.146072963898772,0.0292024908532129,5.67173777576756e-07,17,"CCNT1; CDK9; ELL; GTF2F2; NELFA; NELFB; NELFCD; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L; SUPT16H; SUPT5H"
"R-HSA-167243","Tat-mediated HIV elongation arrest and recovery",-0.146072963898772,0.0292024908532129,5.67173777576756e-07,17,"CCNT1; CDK9; ELL; GTF2F2; NELFA; NELFB; NELFCD; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L; SUPT16H; SUPT5H"
"R-HSA-69242","S Phase",0.150869167841318,0.0303386368083457,6.59793255100961e-07,40,"CCNA1; CCNA2; CDC25A; CDC25B; CDK2; CDK7; CDKN1A; CDKN1B; CKS1B; DNA2; E2F1; E2F5; ESCO1; ESCO2; FEN1; GINS2; GINS4; LIG1; LIN52; LIN54; LIN9; MAX; MCM2; MCM3; MCM4; MCM6; MCM7; MCM8; MYC; ORC2; ORC4; ORC5; PDS5A; PDS5B; POLA2; POLD2; POLD3; POLE; PRIM1; PSMA1"
"R-HSA-3928662","EPHB-mediated forward signaling",0.235543623944054,0.0474778892474951,7.00869767417492e-07,23,"ACTB; ACTG1; ACTR2; ARHGEF28; ARPC1A; ARPC1B; ARPC2; ARPC3; ARPC4; CFL1; FYN; ITSN1; KALRN; LIMK1; LIMK2; LYN; PAK1; RASA1; ROCK1; ROCK2; SDC2; SRC; YES1"
"R-HSA-5633008","TP53 Regulates Transcription of Cell Death Genes",-0.218704970267256,0.0444126320010716,8.46253823924537e-07,22,"AIFM2; ATM; BCL6; BID; CASP10; CRADD; FAS; NDRG1; NLRC4; PERP; PPP1R13B; RABGGTA; STEAP3; TMEM219; TNFRSF10A; TNFRSF10B; TNFRSF10D; TP53; TP53BP2; TP53I3; TP53INP1; ZNF420"
"R-HSA-446203","Asparagine N-linked glycosylation",0.249210733262244,0.0508501124802581,9.5404177086405e-07,36,"ACTR10; ALG1; ALG10; ALG12; ALG8; AMFR; ANK1; ANKRD28; ARF1; ARF3; ARF4; ARFGAP3; ASGR1; B4GALT2; B4GALT3; B4GALT4; B4GALT5; B4GALT6; BET1; CALR; CANX; CAPZA2; CAPZB; CD55; CD59; CHST10; CHST8; CNIH3; COG1; COG2; COG3; COG4; COG6; COG7; COG8; COPA"
"R-HSA-162906","HIV Infection",-0.122992396044782,0.0251896013986316,1.04661365757596e-06,41,"AAAS; AP1B1; AP1M1; AP1S1; AP2A2; AP2B1; AP2M1; APOBEC3G; ARF1; ATP6V1H; BANF1; BTRC; CCNK; CCNT1; CCNT2; CD4; CDK7; CDK9; CHMP2A; CHMP2B; CHMP3; CHMP4A; CHMP4B; CHMP7; CUL5; DOCK2; ELL; ELMO1; ERCC2; ERCC3; FEN1; FURIN; FYN; GTF2A1; GTF2A2; GTF2E1; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4"
"R-HSA-452723","Transcriptional regulation of pluripotent stem cells",-0.156534922111085,0.0322032475910701,1.16887085194408e-06,17,"DKK1; FOXP1; HHEX; HIF3A; KLF4; NR6A1; PBX1; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L; SALL1; STAT3"
"R-HSA-140534","Ligand-dependent caspase activation",0.415469721941357,0.0858834765801195,1.31417691279712e-06,10,"CASP8; CD14; FADD; FAS; TICAM1; TLR4; TNFRSF10A; TNFRSF10B; TNFSF10; TRADD"
"R-HSA-8863795","Downregulation of ERBB2 signaling",-0.137900062639364,0.0285477319900757,1.36184785690301e-06,18,"AKT1; AKT2; AKT3; BTC; CDC37; CUL5; EGF; EGFR; ERBB2; ERBB3; ERBB4; HSP90AA1; NRG2; NRG4; PTPN12; PTPN18; UBA52; UBC"
"R-HSA-192823","Viral mRNA Translation",0.217290307469399,0.0451070400640402,1.45575844908707e-06,28,"DNAJC3; RPL10A; RPL12; RPL13; RPL14; RPL15; RPL17; RPL23; RPL26; RPL26L1; RPL27; RPL27A; RPL29; RPL3; RPL31; RPL35; RPL36; RPL36AL; RPL37A; RPL4; RPL6; RPL7; RPL8; RPL9; RPLP0; RPS12; RPS13; RPS14"
"R-HSA-3700989","Transcriptional Regulation by TP53",0.146233447273852,0.0305654175401309,1.71603249322362e-06,34,"AGO2; AIFM2; AKT1; AKT2; AKT3; ARID3A; ATM; ATRIP; BARD1; BCL6; BID; BLM; BRD7; BRIP1; BRPF1; CARM1; CASP10; CCNA1; CCNA2; CCNG1; CCNK; CCNT1; CCNT2; CDK12; CDK13; CDK2; CDK5; CDK5R1; CDK7; CDK9; CDKN1A; CDKN1B; CENPJ; CHEK1"
"R-HSA-73728","RNA Polymerase I Promoter Opening",0.172912168093978,0.0361578518229112,1.73432641720891e-06,13,"H2AFV; H2AFZ; H3F3A; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; MAPK3; UBTF"
"R-HSA-8953854","Metabolism of RNA",0.193992448854794,0.0406224970125944,1.79267555234073e-06,41,"AAAS; ACTB; ADAR; ADARB1; ADAT1; ADAT2; AKT1; ALKBH8; ANP32A; AQR; BCAS2; BMS1; BYSL; C1D; C2orf49; CASC3; CCAR1; CD44; CDC40; CDK7; CDKAL1; CHERP; CHTOP; CNOT11; CNOT2; CNOT4; CNOT6L; CNOT7; CNOT8; CPSF1; CPSF2; CPSF3; CPSF4; CPSF7; CSNK1D; CSTF1; CSTF2T; CTNNBL1; CTU1; CTU2; CWC15"
"R-HSA-445144","Signal transduction by L1",0.244390073512831,0.0513668987382343,1.95777625360946e-06,11,"CSNK2A2; EGFR; FGFR1; ITGA9; ITGAV; ITGB3; MAPK1; MAPK3; NRP1; PAK1; VAV2"
"R-HSA-6807878","COPI-mediated anterograde transport",0.210767592142425,0.0445012344006891,2.17742285959688e-06,43,"ACTR10; ANK1; ARF1; ARF3; ARF4; ARFGAP3; BET1; CAPZA2; CAPZB; CD55; CD59; COG1; COG2; COG3; COG4; COG6; COG7; COG8; COPA; COPE; COPG2; COPZ1; COPZ2; DCTN3; DCTN5; DCTN6; DYNC1H1; DYNC1LI2; DYNLL2; GBF1; GOLGA2; GOLGB1; GORASP1; GOSR1; GOSR2; KDELR1; KDELR2; KDELR3; NAPA; NAPB; NAPG; NSF; RAB1A"
"R-HSA-71387","Metabolism of carbohydrates",0.231726429360157,0.049324285145989,2.62696984031604e-06,38,"AAAS; ABCC5; ACAN; ADPGK; AGL; ALDH1A1; ALDOB; ALDOC; ARSB; B3GALT6; B3GAT1; B3GAT2; B4GALT2; B4GALT3; B4GALT4; B4GALT5; B4GALT6; BPGM; CALM1; CD44; CHPF; CHST1; CHST11; CHST12; CHST3; CHST6; CHST9; CHSY3; CRYL1; CSGALNACT1; CSGALNACT2; DCN; DCXR; DSE; ENO1; ENO3; EXT1; EXT2"
"R-HSA-6802952","Signaling by BRAF and RAF fusions",0.184414519832864,0.039256540976809,2.63138101596491e-06,29,"AGGF1; AGTRAP; AP3B1; ARRB1; ARRB2; ATG7; BCL2L11; CLCN6; FAM114A2; IQGAP1; ITGB3; JAK2; KIAA1549; KRAS; KSR1; KSR2; MAPK1; MAPK3; MPRIP; PAPSS1; PEBP1; RAP1A; SND1; SRC; TLN1; TRAK1; TRIM24; VCL; VWF"
"R-HSA-72306","tRNA processing",0.310347398072345,0.0662469593218953,2.80364749197424e-06,18,"AAAS; ADAT1; ADAT2; ALKBH8; C2orf49; CDKAL1; CPSF1; CPSF4; CTU1; CTU2; DUS2; ELAC2; GTPBP3; LCMT2; MTO1; NDC1; NSUN2; NSUN6"
"R-HSA-112409","RAF-independent MAPK1/3 activation",0.229563231927164,0.049105564623819,2.94107748740136e-06,11,"DUSP16; DUSP4; DUSP6; DUSP7; IL6ST; JAK1; JAK2; MAPK1; MAPK3; PTPN11; TYK2"
"R-HSA-6802948","Signaling by high-kinase activity BRAF mutants",0.201169083470099,0.0431055888287321,3.05791480286844e-06,15,"ARRB1; ARRB2; IQGAP1; ITGB3; KRAS; KSR1; KSR2; MAPK1; MAPK3; PEBP1; RAP1A; SRC; TLN1; VCL; VWF"
"R-HSA-8878159","Transcriptional regulation by RUNX3",-0.0936736758686713,0.0200984491829709,3.15072256687491e-06,33,"BCL2L11; CARM1; CDKN1A; CHD9; HDAC4; HES1; ITGA4; JAG1; KAT2B; KRAS; MAML1; MDM2; MYC; NCOA1; NCOA6; NOTCH1; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5"
"R-HSA-203927","MicroRNA (miRNA) biogenesis",-0.151061408179863,0.0325091924893941,3.37239692749084e-06,13,"AGO2; DGCR8; DICER1; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L; PRKRA; RAN"
"R-HSA-4641262","Disassembly of the destruction complex and recruitment of AXIN to the membrane",0.236349262833187,0.0509694958618752,3.53377977230365e-06,17,"AXIN1; CAV1; DVL1; DVL2; FRAT1; FRAT2; FZD1; GSK3B; LRP5; LRP6; PPP2CA; PPP2R1A; PPP2R1B; PPP2R5A; PPP2R5C; PPP2R5D; PPP2R5E"
"R-HSA-5693565","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks",-0.12498129369774,0.0270157806431196,3.72376518760988e-06,22,"ATM; BAP1; BARD1; EYA4; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; MAPK8; MDC1; NBN; PPP5C; RAD50; RNF8; TP53; UBA52; UBC; UBE2I; UBE2N; UIMC1"
"R-HSA-5693606","DNA Double Strand Break Response",-0.12498129369774,0.0270157806431196,3.72376518760988e-06,22,"ATM; BAP1; BARD1; EYA4; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; MAPK8; MDC1; NBN; PPP5C; RAD50; RNF8; TP53; UBA52; UBC; UBE2I; UBE2N; UIMC1"
"R-HSA-9013507","NOTCH3 Activation and Transmission of Signal to the Nucleus",-0.153951158228699,0.0332814926393372,3.7328351690284e-06,14,"ADAM10; DLL4; EGF; EGFR; JAG1; MIB1; NOTCH3; PSEN1; PSEN2; TACC3; UBA52; UBC; WWP2; YBX1"
"R-HSA-2173795","Downregulation of SMAD2/3:SMAD4 transcriptional activity",-0.16060230475071,0.0347863819161886,3.89673550600407e-06,10,"HDAC1; NCOR1; NCOR2; PARP1; PPM1A; SKIL; SMAD3; TRIM33; UBA52; UBC"
"R-HSA-5693579","Homologous DNA Pairing and Strand Exchange",-0.139338780580346,0.0302807643773334,4.19336562001946e-06,29,"ATM; ATRIP; BARD1; BLM; BRCA2; BRIP1; CHEK1; DNA2; EXO1; NBN; PALB2; RAD1; RAD50; RAD51B; RAD51C; RAD9A; RFC2; RFC3; RFC4; RFC5; RMI1; RMI2; RPA1; RPA2; RPA3; TOP3A; TOPBP1; WRN; XRCC2"
"R-HSA-69306","DNA Replication",0.110774000274304,0.0241052147645765,4.31842875544812e-06,36,"CCNA1; CCNA2; CDC7; CDK2; CDKN1A; CDKN1B; DBF4; DNA2; E2F1; FEN1; GINS2; GINS4; LIG1; MCM2; MCM3; MCM4; MCM6; MCM7; MCM8; ORC2; ORC4; ORC5; POLA2; POLD2; POLD3; POLE; PRIM1; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6"
"R-HSA-1445148","Translocation of GLUT4 to the plasma membrane",0.217070539280027,0.0475114978328432,4.9052418362363e-06,33,"AKT1; AKT2; ASPSCR1; CALM1; EXOC1; EXOC2; EXOC3; EXOC4; EXOC6; EXOC7; KIF3B; KIFAP3; MYH3; MYO5A; PRKAA2; PRKAB2; PRKAG2; RAB11A; RAB14; RAB8A; RALA; RALGAPA2; RALGAPB; SLC2A4; SNAP23; STX4; TBC1D1; TBC1D4; VAMP2; YWHAE; YWHAG; YWHAQ; YWHAZ"
"R-HSA-1963642","PI3K events in ERBB2 signaling",0.20197992476403,0.0442380998748071,4.97721283151935e-06,12,"BTC; EGF; EGFR; ERBB2; ERBB3; ERBB4; GAB1; GRB2; NRG2; NRG4; PIK3CA; PIK3R1"
"R-HSA-8957322","Metabolism of steroids",-0.188761680844573,0.0413548620808489,5.00835516282423e-06,32,"ACACA; ACACB; ACOT8; ACOX2; AKR1C1; AKR1C2; AKR1C3; AMACR; ARV1; BAAT; CARM1; CHD9; CUBN; CYP2R1; CYP39A1; CYP51A1; CYP7B1; DHCR24; DHCR7; FASN; FDPS; FDX1; FDXR; GGPS1; GPAM; HMGCS1; HSD17B1; HSD17B11; HSD17B12; HSD17B14; HSD17B4; HSD17B7"
"R-HSA-156842","Eukaryotic Translation Elongation",0.199502434604738,0.0441861844328287,6.3304515430305e-06,32,"EEF1A1; EEF1A1P5; EEF1A2; EEF2; RPL10A; RPL12; RPL13; RPL14; RPL15; RPL17; RPL23; RPL26; RPL26L1; RPL27; RPL27A; RPL29; RPL3; RPL31; RPL35; RPL36; RPL36AL; RPL37A; RPL4; RPL6; RPL7; RPL8; RPL9; RPLP0; RPS12; RPS13; RPS14; RPS15"
"R-HSA-450321","JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1",-0.183604731264684,0.0408596370630324,7.00462972560349e-06,11,"IRAK2; MAP2K7; MAP3K7; MAPK10; MAPK8; NOD1; TAB1; TAB2; TRAF6; UBE2N; UBE2V1"
"R-HSA-72764","Eukaryotic Translation Termination",0.199455036791155,0.0445651706882064,7.62037562560811e-06,30,"ETF1; N6AMT1; RPL10A; RPL12; RPL13; RPL14; RPL15; RPL17; RPL23; RPL26; RPL26L1; RPL27; RPL27A; RPL29; RPL3; RPL31; RPL35; RPL36; RPL36AL; RPL37A; RPL4; RPL6; RPL7; RPL8; RPL9; RPLP0; RPS12; RPS13; RPS14; RPS15"
"R-HSA-927802","Nonsense-Mediated Decay (NMD)",0.167041195174701,0.0373608148128145,7.78450304758127e-06,32,"CASC3; DCP1A; ETF1; MAGOHB; NCBP1; NCBP2; PPP2CA; PPP2R1A; RNPS1; RPL10A; RPL12; RPL13; RPL14; RPL15; RPL17; RPL23; RPL26; RPL26L1; RPL27; RPL27A; RPL29; RPL3; RPL31; RPL35; RPL36; RPL36AL; RPL37A; RPL4; RPL6; RPL7; RPL8; RPL9"
"R-HSA-975957","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)",0.167041195174701,0.0373608148128145,7.78450304758127e-06,32,"CASC3; DCP1A; ETF1; MAGOHB; NCBP1; NCBP2; PPP2CA; PPP2R1A; RNPS1; RPL10A; RPL12; RPL13; RPL14; RPL15; RPL17; RPL23; RPL26; RPL26L1; RPL27; RPL27A; RPL29; RPL3; RPL31; RPL35; RPL36; RPL36AL; RPL37A; RPL4; RPL6; RPL7; RPL8; RPL9"
"R-HSA-156902","Peptide chain elongation",0.192359865947144,0.0433088176094756,8.92979755320391e-06,33,"EEF1A1; EEF2; RPL10A; RPL12; RPL13; RPL14; RPL15; RPL17; RPL23; RPL26; RPL26L1; RPL27; RPL27A; RPL29; RPL3; RPL31; RPL35; RPL36; RPL36AL; RPL37A; RPL4; RPL6; RPL7; RPL8; RPL9; RPLP0; RPS12; RPS13; RPS14; RPS15; RPS19; RPS2; RPS20"
"R-HSA-373076","Class A/1 (Rhodopsin-like receptors)",0.293880013267353,0.0662008001792856,9.02848752180832e-06,19,"ACKR3; ACKR4; ADORA2B; ADRA1A; ADRA1B; ADRA2C; ADRB2; AGT; ANXA1; APLNR; APP; C5; CCKBR; CCR1; CCR6; CHRM1; CHRM4; CHRM5; CMKLR1"
"R-HSA-1912422","Pre-NOTCH Expression and Processing",0.229000121663926,0.0517526998170499,9.64904201893702e-06,21,"AGO2; ATP2A2; E2F1; FURIN; JUN; KAT2B; LFNG; MAML1; NOTCH1; NOTCH3; POGLUT1; RAB6A; RBPJ; RFNG; SNW1; ST3GAL3; ST3GAL4; ST3GAL6; TFDP1; TMED2; TP53"
"R-HSA-186712","Regulation of beta-cell development",0.231109464485965,0.0522772648880829,9.83175999261078e-06,13,"AKT1; AKT2; AKT3; FGF10; FOXO1; HES1; HNF1A; INSM1; NEUROD1; NKX2-2; NOTCH1; PAX6; RBPJ"
"R-HSA-512988","Interleukin-3, 5 and GM-CSF signaling",0.171736751385498,0.0388861331740024,1.00357904650016e-05,20,"BLNK; CBL; CRK; CRKL; FYN; GRB2; INPP5D; JAK1; JAK2; JAK3; LYN; PIK3CA; PIK3CB; PIK3CD; PIK3R1; PRKACA; PTPN11; TEC; YES1; YWHAZ"
"R-HSA-114508","Effects of PIP2 hydrolysis",-0.215021392763429,0.0486969971329543,1.00778675007298e-05,14,"ABHD12; ABHD6; DAGLB; DGKA; DGKE; DGKG; DGKQ; ITPR2; ITPR3; MGLL; PRKCD; PRKCQ; RASGRP1; TRPC6"
"R-HSA-5674135","MAP2K and MAPK activation",0.18749792143421,0.0426715584342837,1.11294694357536e-05,17,"ARRB1; ARRB2; IQGAP1; ITGB3; KRAS; KSR1; KSR2; LAMTOR3; MAPK1; MAPK3; PEBP1; RAP1A; SRC; TLN1; VCL; VWF; WDR83"
"R-HSA-8936459","RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function",0.151578880242923,0.0345815132458411,1.16930156130167e-05,26,"ASH2L; DPY30; H2AFV; H2AFZ; H3F3A; HDAC1; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; KAT2B; KMT2B; KMT2C; KMT2D; KMT2E; PRKCQ; PRMT1; PRMT6; RBBP5; RUNX1; SIN3B; WDR5"
"R-HSA-8948216","Collagen chain trimerization",-0.210481393589953,0.0480612875141616,1.18986168020436e-05,20,"COL11A2; COL12A1; COL14A1; COL15A1; COL16A1; COL18A1; COL19A1; COL22A1; COL23A1; COL24A1; COL26A1; COL27A1; COL28A1; COL4A4; COL5A2; COL5A3; COL6A1; COL6A2; COL6A3; COL8A1"
"R-HSA-114608","Platelet degranulation ",0.223970373491183,0.0514200721537159,1.32642751052738e-05,24,"A2M; ABCC4; ANXA5; APLP2; APP; CALM1; CALU; CD109; CD36; CD9; CDC37L1; CFL1; CHID1; CLEC3B; EGF; ENDOD1; F5; FERMT3; HABP4; HSPA5; IGF1; ISLR; ITGB3; MMRN1"
"R-HSA-76005","Response to elevated platelet cytosolic Ca2+",0.223970373491183,0.0514200721537159,1.32642751052738e-05,24,"A2M; ABCC4; ANXA5; APLP2; APP; CALM1; CALU; CD109; CD36; CD9; CDC37L1; CFL1; CHID1; CLEC3B; EGF; ENDOD1; F5; FERMT3; HABP4; HSPA5; IGF1; ISLR; ITGB3; MMRN1"
"R-HSA-68874","M/G1 Transition",-0.0860686985183899,0.0198793968331126,1.49419260524725e-05,34,"CDC7; CDK2; DBF4; E2F1; MCM2; MCM3; MCM4; MCM6; MCM7; MCM8; ORC2; ORC4; ORC5; POLA2; POLE; PRIM1; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6"
"R-HSA-69002","DNA Replication Pre-Initiation",-0.0860686985183899,0.0198793968331126,1.49419260524725e-05,34,"CDC7; CDK2; DBF4; E2F1; MCM2; MCM3; MCM4; MCM6; MCM7; MCM8; ORC2; ORC4; ORC5; POLA2; POLE; PRIM1; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6"
"R-HSA-1483257","Phospholipid metabolism",0.278639131329181,0.0645262950642366,1.57288259518984e-05,36,"ABHD4; ACHE; ACP6; AGPAT3; AGPAT4; ARF1; ARF3; BCHE; CDS1; CDS2; CEPT1; CHKA; CHKB; CHPT1; CPNE1; CPNE3; CPNE6; CPNE7; CRLS1; CSNK2A2; DDHD1; DDHD2; DGAT2; ENPP6; ETNK1; FIG4; GPAM; GPAT2; GPCPD1; GPD1L; GPD2; HADHA; HADHB; INPP4B; INPP5D; INPP5E"
"R-HSA-74751","Insulin receptor signalling cascade",0.130244503413722,0.0303005109422588,1.7201532762778e-05,23,"AKT2; FGF1; FGF10; FGF17; FGF5; FGF9; FGFR1; FGFR2; GAB1; GRB2; KL; KLB; KRAS; MAPK1; MAPK3; PDE3B; PIK3C3; PIK3CA; PIK3CB; PIK3R1; PTPN11; THEM4; TRIB3"
"R-HSA-5693571","Nonhomologous End-Joining (NHEJ)",0.174113673029582,0.0405785352539688,1.78044550825255e-05,22,"ATM; BARD1; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; LIG4; MDC1; NBN; POLL; POLM; RAD50; RIF1; RNF8; TDP1; TDP2; UBE2N; UIMC1; XRCC4; XRCC6"
"R-HSA-9013508","NOTCH3 Intracellular Domain Regulates Transcription",0.329437507412456,0.0771164048783205,1.93770110198879e-05,10,"HES1; HEY2; KAT2B; MAML1; NOTCH1; NOTCH3; PBX1; PLXND1; RBPJ; SNW1"
"R-HSA-75153","Apoptotic execution  phase",-0.171106734908954,0.0401583464244964,2.03695265552786e-05,33,"ACIN1; ADD1; BIRC2; CASP3; CASP7; CASP8; CDH1; DBNL; DFFB; DNM1L; DSG2; DSP; GAS2; GSN; H1F0; HIST1H1A; HIST1H1C; HIST1H1D; HMGB2; LMNB1; MAPT; OCLN; PAK2; PKP1; PLEC; PRKCD; PRKCQ; ROCK1; SATB1; STK24; TJP1; TJP2; VIM"
"R-HSA-69202","Cyclin E associated events during G1/S transition ",0.0811638478275478,0.0191309869632756,2.21010808143045e-05,39,"AKT1; AKT2; AKT3; CCNA1; CCNA2; CDC25A; CDK2; CDK7; CDKN1A; CDKN1B; CKS1B; E2F1; E2F5; LIN52; LIN54; LIN9; MAX; MYC; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSMF1"
"R-HSA-975956","Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)",0.172715559067608,0.0407848331475342,2.28756514690083e-05,31,"ETF1; NCBP1; NCBP2; RPL10A; RPL12; RPL13; RPL14; RPL15; RPL17; RPL23; RPL26; RPL26L1; RPL27; RPL27A; RPL29; RPL3; RPL31; RPL35; RPL36; RPL36AL; RPL37A; RPL4; RPL6; RPL7; RPL8; RPL9; RPLP0; RPS12; RPS13; RPS14; RPS15"
"R-HSA-5620920","Cargo trafficking to the periciliary membrane",0.281504251123247,0.066483349744479,2.29359817716846e-05,35,"ARF4; ARL3; ASAP1; BBS1; BBS10; BBS12; BBS2; BBS4; BBS5; BBS7; BBS9; CCT3; CCT4; CCT5; CCT8; CYS1; EXOC1; EXOC2; EXOC3; EXOC4; EXOC6; EXOC7; GBF1; INPP5E; MCHR1; MKKS; NPHP3; PDE6D; PKD2; RAB11A; RAB3IP; RAB8A; SMO; SSTR3; TTC8"
"R-HSA-5218921","VEGFR2 mediated cell proliferation",0.200142850880074,0.0473327389482395,2.35334833142982e-05,14,"AHCYL1; CALM1; ITPR2; ITPR3; KDR; KRAS; PLCG1; PRKCA; PRKCB; PRKCD; RASA1; SPHK1; SRC; VEGFA"
"R-HSA-2408522","Selenoamino acid metabolism",0.205156844859354,0.0485645529120751,2.39561828342141e-05,31,"AHCY; AIMP1; CBS; EEFSEC; IARS; INMT; KARS; LARS; PAPSS1; PSTK; QARS; RARS; RPL10A; RPL12; RPL13; RPL14; RPL15; RPL17; RPL23; RPL26; RPL26L1; RPL27; RPL27A; RPL29; RPL3; RPL31; RPL35; RPL36; RPL36AL; RPL37A; RPL4"
"R-HSA-9008059","Interleukin-37 signaling",-0.211223078905303,0.0500137694945846,2.4075259181824e-05,16,"IL18BP; IL18R1; PTPN11; PTPN12; PTPN13; PTPN14; PTPN18; PTPN2; PTPN23; PTPN4; PTPN5; PTPN9; SIGIRR; SMAD3; STAT3; TBK1"
"R-HSA-5617833","Cilium Assembly",0.185395953906889,0.0439265511023405,2.43663958305104e-05,41,"AHI1; ALMS1; ARF4; ARL3; ASAP1; BBS1; BBS10; BBS12; BBS2; BBS4; BBS5; BBS7; BBS9; C2CD3; CC2D2A; CCT3; CCT4; CCT5; CCT8; CDK5RAP2; CENPJ; CEP135; CEP164; CEP192; CEP250; CEP290; CEP41; CEP57; CEP63; CEP72; CEP76; CEP89; CKAP5; CLUAP1; CNTRL; CSNK1D; CYS1; DCTN3; DYNC1H1; DYNC2H1; DYNC2LI1"
"R-HSA-5627117","RHO GTPases Activate ROCKs",0.338084245091542,0.0801708174470048,2.47520484774747e-05,12,"CFL1; LIMK1; LIMK2; MYH10; MYH11; MYH14; MYH9; PAK1; PPP1CB; RHOB; ROCK1; ROCK2"
"R-HSA-4791275","Signaling by WNT in cancer",0.220297383864754,0.0524837061510083,2.699451413801e-05,20,"AXIN1; CTBP2; DKK1; FZD6; FZD8; GSK3B; KREMEN1; KREMEN2; LRP5; LRP6; PPP2CA; PPP2R1A; PPP2R1B; PPP2R5A; PPP2R5C; PPP2R5D; PPP2R5E; RNF43; TNKS; TNKS2"
"R-HSA-166208","mTORC1-mediated signalling",-0.202754018782107,0.0484485936159561,2.85252800849656e-05,12,"EEF2K; EIF4B; EIF4E; EIF4EBP1; LAMTOR3; LAMTOR4; LAMTOR5; MLST8; MTOR; RPS6KB1; RPTOR; SLC38A9"
"R-HSA-912631","Regulation of signaling by CBL",0.190221778560431,0.0454757490151098,2.87778700420158e-05,12,"BLNK; CBL; CRK; CRKL; FYN; GRB2; LYN; PIK3CA; PIK3CB; PIK3CD; PIK3R1; YES1"
"R-HSA-8856688","Golgi-to-ER retrograde transport",0.202745445896087,0.0484959892281212,2.90658836927785e-05,38,"ACTR10; AGPAT3; ARF1; ARF3; ARF4; ARFGAP3; BICD1; BICD2; BNIP1; CAPZA2; CAPZB; CENPE; COPA; COPE; COPG2; COPZ1; COPZ2; DCTN3; DCTN5; DCTN6; DYNC1H1; DYNC1LI2; DYNLL2; GALNT1; GALNT2; GBF1; KDELR1; KDELR2; KDELR3; KIF13B; KIF15; KIF16B; KIF19; KIF20B; KIF21A; KIF21B; KIF22; KIF27"
"R-HSA-1236974","ER-Phagosome pathway",0.0879094243946119,0.0210998984458958,3.09524229824532e-05,33,"CALR; CD14; CD36; HLA-A; HLA-B; HLA-C; HLA-E; PDIA3; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; SEC61A2; SEC61B; SEC61G"
"R-HSA-162909","Host Interactions of HIV factors",-0.0964134644396837,0.023300519283552,3.50614062374395e-05,41,"AAAS; AP1B1; AP1M1; AP1S1; AP2A2; AP2B1; AP2M1; APOBEC3G; ARF1; ATP6V1H; BANF1; BTRC; CCNT1; CD4; CDK9; CUL5; DOCK2; ELMO1; FYN; HLA-A; HMGA1; NDC1; NPM1; NUP107; NUP205; NUP214; NUP35; NUP37; NUP43; NUP50; NUP54; NUP62; NUP85; NUP88; NUP93; PACS1; PAK2; POM121; POM121C; PSIP1; PSMA1"
"R-HSA-6783783","Interleukin-10 signaling",-0.218267820358778,0.0527768874035029,3.53919602751892e-05,12,"CCL2; CCR1; CSF1; FPR1; ICAM1; IL10RB; IL12A; IL1R1; JAK1; PTAFR; STAT3; TYK2"
"R-HSA-2404192","Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)",0.135163264692309,0.0327175609404457,3.60851543973377e-05,23,"AKT2; FGF1; FGF10; FGF17; FGF5; FGF9; FGFR1; FGFR2; GAB1; GRB2; IGF1; IGF1R; KL; KLB; KRAS; PDE3B; PIK3C3; PIK3CA; PIK3CB; PIK3R1; PTPN11; THEM4; TRIB3"
"R-HSA-2428924","IGF1R signaling cascade",0.135163264692309,0.0327175609404457,3.60851543973377e-05,23,"AKT2; FGF1; FGF10; FGF17; FGF5; FGF9; FGFR1; FGFR2; GAB1; GRB2; IGF1; IGF1R; KL; KLB; KRAS; PDE3B; PIK3C3; PIK3CA; PIK3CB; PIK3R1; PTPN11; THEM4; TRIB3"
"R-HSA-2428928","IRS-related events triggered by IGF1R",0.135163264692309,0.0327175609404457,3.60851543973377e-05,23,"AKT2; FGF1; FGF10; FGF17; FGF5; FGF9; FGFR1; FGFR2; GAB1; GRB2; IGF1; IGF1R; KL; KLB; KRAS; PDE3B; PIK3C3; PIK3CA; PIK3CB; PIK3R1; PTPN11; THEM4; TRIB3"
"R-HSA-1592230","Mitochondrial biogenesis",-0.142877272727539,0.0347563556287976,3.94249054185483e-05,28,"ACSS2; CALM1; CAMK4; CARM1; CHCHD6; CHD9; CREB1; CRTC1; CRTC2; CRTC3; CYCS; DNAJC11; HDAC3; HSPA9; IDH2; IMMT; MAPK11; MAPK12; MAPK14; MEF2C; MEF2D; MTX1; MTX2; NCOA1; NCOA6; NCOR1; NR1D1; NRF1"
"R-HSA-8878166","Transcriptional regulation by RUNX2",-0.0891703224123986,0.0217496763192643,4.13425236912671e-05,27,"AKT1; AKT2; AKT3; BMP2; CDKN1A; DLX6; ESR1; GSK3B; HDAC3; HDAC4; HES1; HEY2; LGALS3; MAPK1; MAPK3; PPM1D; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3"
"R-HSA-1799339","SRP-dependent cotranslational protein targeting to membrane",0.183761658584855,0.0450740746634574,4.56437503227085e-05,29,"RPL10A; RPL12; RPL13; RPL14; RPL15; RPL17; RPL23; RPL26; RPL26L1; RPL27; RPL27A; RPL29; RPL3; RPL31; RPL35; RPL36; RPL36AL; RPL37A; RPL4; RPL6; RPL7; RPL8; RPL9; RPLP0; RPN1; RPS12; RPS13; RPS14; RPS15"
"R-HSA-948021","Transport to the Golgi and subsequent modification",0.182207856407091,0.0447369896573476,4.64377328913541e-05,40,"ACTR10; ANK1; ANKRD28; ARF1; ARF3; ARF4; ARFGAP3; B4GALT2; B4GALT3; B4GALT4; B4GALT5; B4GALT6; BET1; CAPZA2; CAPZB; CD55; CD59; CHST10; CHST8; CNIH3; COG1; COG2; COG3; COG4; COG6; COG7; COG8; COPA; COPE; COPG2; COPZ1; COPZ2; CSNK1D; CTSC; CTSZ; DCTN3; DCTN5; DCTN6; DYNC1H1; DYNC1LI2"
"R-HSA-112399","IRS-mediated signalling",0.133650347266367,0.0329489961202603,4.98605258758259e-05,21,"AKT2; FGF1; FGF10; FGF17; FGF5; FGF9; FGFR1; FGFR2; GAB1; GRB2; KL; KLB; KRAS; PDE3B; PIK3C3; PIK3CA; PIK3CB; PIK3R1; PTPN11; THEM4; TRIB3"
"R-HSA-418555","G alpha (s) signalling events",-0.132227137397878,0.0326271636406598,5.06363368736357e-05,26,"ADCY3; ADCY6; ADCY7; ADCYAP1; ADCYAP1R1; ADM; ADORA2B; ADRB2; ARRB1; ARRB2; CALCRL; CRH; CRHR1; CRHR2; DRD5; GLP2R; GNAI2; GNAZ; GNB2; GNB3; GNB4; GNB5; GNG11; GNG4; GNG5; GNG7"
"R-HSA-111465","Apoptotic cleavage of cellular proteins",-0.176096117679031,0.043532312192931,5.22825318632686e-05,25,"ACIN1; ADD1; BIRC2; CASP3; CASP7; CASP8; CDH1; DBNL; DSG2; DSP; GAS2; GSN; LMNB1; MAPT; OCLN; PKP1; PLEC; PRKCD; PRKCQ; ROCK1; SATB1; STK24; TJP1; TJP2; VIM"
"R-HSA-211000","Gene Silencing by RNA",0.105993058937114,0.0262103006222354,5.25588706805605e-05,33,"AAAS; AGO2; DGCR8; DICER1; H2AFV; H2AFZ; H3F3A; HENMT1; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; HSP90AA1; IPO8; MAEL; MOV10L1; MYBL1; NDC1; NUP107; NUP205; NUP214; NUP35; NUP37; NUP43; NUP50; NUP54; NUP62; NUP85; NUP88"
"R-HSA-6802957","Oncogenic MAPK signaling",0.156754041931241,0.0388014676977936,5.34740399285876e-05,34,"AGGF1; AGTRAP; AP3B1; ARRB1; ARRB2; ATG7; BCL2L11; CLCN6; FAM114A2; IQGAP1; ITGB3; JAK2; KIAA1549; KRAS; KSR1; KSR2; MAPK1; MAPK3; MPRIP; NF1; PAPSS1; PEBP1; RAP1A; RASA1; RASA2; RASA3; RASA4; RASAL1; RASAL2; RASAL3; SND1; SPRED2; SRC; TLN1"
"R-HSA-6811442","Intra-Golgi and retrograde Golgi-to-ER traffic",0.186206338671359,0.0461342531011606,5.43275923690275e-05,43,"ACTR10; AGPAT3; ARF1; ARF3; ARF4; ARFGAP3; ARFRP1; ARL1; BICD1; BICD2; BNIP1; CAPZA2; CAPZB; CENPE; COG1; COG2; COG3; COG4; COG6; COG7; COG8; COPA; COPE; COPG2; COPZ1; COPZ2; CYTH1; CYTH2; DCTN3; DCTN5; DCTN6; DYNC1H1; DYNC1LI2; DYNLL2; GALNT1; GALNT2; GBF1; GCC1; GCC2; GOLGA1; GOLGA5; GOLIM4; GOSR1"
"R-HSA-381676","Glucagon-like Peptide-1 (GLP1) regulates insulin secretion",0.164793832161588,0.0408637306406358,5.51243434682675e-05,22,"ADCY6; AKAP5; GNB2; GNB3; GNB4; GNB5; GNG11; GNG4; GNG5; GNG7; IQGAP1; ITPR2; ITPR3; KCNB1; KCNC2; PRKACA; PRKAR1A; PRKAR1B; PRKAR2A; RAP1A; RAPGEF3; RAPGEF4"
"R-HSA-3371453","Regulation of HSF1-mediated heat shock response",0.113722272228664,0.0282465701540015,5.67201949361798e-05,36,"AAAS; ATM; BAG2; BAG4; BAG5; DNAJC7; GSK3B; HSBP1; HSF1; HSPA12B; HSPA2; HSPA4; HSPA5; HSPA6; HSPA8; HSPA9; HSPH1; MAPK1; MAPK3; MRPL18; NDC1; NUP107; NUP205; NUP214; NUP35; NUP37; NUP43; NUP50; NUP54; NUP62; NUP85; NUP88; NUP93; POM121; POM121C; RAE1"
"R-HSA-74752","Signaling by Insulin receptor",0.119768155307842,0.0297926454541627,5.81838764917146e-05,32,"AKT2; ATP6V0A2; ATP6V0B; ATP6V0C; ATP6V0D1; ATP6V0E1; ATP6V0E2; ATP6V1C1; ATP6V1C2; ATP6V1E1; ATP6V1E2; ATP6V1G1; ATP6V1H; FGF1; FGF10; FGF17; FGF5; FGF9; FGFR1; FGFR2; GAB1; GRB2; KL; KLB; KRAS; MAPK1; MAPK3; PDE3B; PIK3C3; PIK3CA; PIK3CB; PIK3R1"
"R-HSA-3928663","EPHA-mediated growth cone collapse",0.268141058510533,0.0667661202630064,5.91629824901951e-05,10,"FYN; LYN; MYH10; MYH11; MYH14; MYH9; ROCK1; ROCK2; SRC; YES1"
"R-HSA-390466","Chaperonin-mediated protein folding",0.162087137004706,0.0404074483759507,6.03806390889358e-05,32,"ACTB; AP3M1; ARFGEF2; CCT3; CCT4; CCT5; CCT6B; CCT8; CSNK2A2; DCAF7; FBXO6; FBXW2; FBXW9; FKBP9; GNAI2; GNAO1; GNAZ; GNB2; GNB3; GNB4; GNB5; GNG11; GNG4; GNG5; GNG7; HDAC3; KIF13A; KIFC3; LONP2; NOP56; PFDN4; PFDN5"
"R-HSA-391251","Protein folding",0.162087137004706,0.0404074483759507,6.03806390889358e-05,32,"ACTB; AP3M1; ARFGEF2; CCT3; CCT4; CCT5; CCT6B; CCT8; CSNK2A2; DCAF7; FBXO6; FBXW2; FBXW9; FKBP9; GNAI2; GNAO1; GNAZ; GNB2; GNB3; GNB4; GNB5; GNG11; GNG4; GNG5; GNG7; HDAC3; KIF13A; KIFC3; LONP2; NOP56; PFDN4; PFDN5"
"R-HSA-5654732","Negative regulation of FGFR3 signaling",-0.105271793480199,0.0263006421971518,6.26416834679941e-05,16,"CBL; FGF1; FGF17; FGF5; FGF9; GRB2; MAPK1; MAPK3; MKNK1; PPP2CA; PPP2R1A; PTPN11; SPRY2; SRC; UBA52; UBC"
"R-HSA-5628897","TP53 Regulates Metabolic Genes",0.182213902808386,0.0455952015457696,6.43294733224602e-05,33,"AGO2; AKT1; AKT2; AKT3; COX11; COX14; COX16; COX18; COX20; COX4I1; COX5A; COX6A1; COX6B1; COX6C; COX7A2L; CYCS; DDIT4; LAMTOR3; LAMTOR4; LAMTOR5; LRPPRC; MLST8; MTOR; PRDX2; PRKAA2; PRKAB2; PRKAG2; PTEN; RPTOR; SCO1; SCO2; SESN1; SESN2"
"R-HSA-1168372","Downstream signaling events of B Cell Receptor (BCR)",0.0814721142848458,0.0204379569583778,6.71076850498497e-05,35,"BTRC; CALM1; CARD11; FKBP1A; KRAS; MALT1; MAP3K7; NFATC1; NFKB1; NFKBIA; NFKBIB; NFKBIE; PPP3CB; PPP3R1; PRKCB; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2"
"R-HSA-69620","Cell Cycle Checkpoints",-0.116620296975132,0.0292893597793968,6.84353857188364e-05,27,"ANAPC16; ANAPC4; ANAPC5; ATM; ATRIP; BARD1; BLM; BRIP1; BUB3; CCNA1; CCNA2; CDC16; CDC25A; CDC7; CDK2; CDKN1A; CDKN1B; CENPC; CENPE; CENPH; CENPL; CENPN; CENPP; CENPQ; CENPT; CHEK1; CKAP5"
"R-HSA-5620916","VxPx cargo-targeting to cilium",0.387409428978912,0.0974099557014291,6.97599476881536e-05,13,"ARF4; ASAP1; EXOC1; EXOC2; EXOC3; EXOC4; EXOC6; EXOC7; GBF1; PKD2; RAB11A; RAB3IP; RAB8A"
"R-HSA-389957","Prefoldin mediated transfer of substrate  to CCT/TriC",0.29570108510108,0.0744044544293272,7.06046361857608e-05,15,"ACTB; CCT3; CCT4; CCT5; CCT6B; CCT8; PFDN4; PFDN5; TUBA1A; TUBA1C; TUBA4A; TUBB2A; TUBB2B; TUBB3; TUBB6"
"R-HSA-389958","Cooperation of Prefoldin and TriC/CCT  in actin and tubulin folding",0.29570108510108,0.0744044544293272,7.06046361857608e-05,15,"ACTB; CCT3; CCT4; CCT5; CCT6B; CCT8; PFDN4; PFDN5; TUBA1A; TUBA1C; TUBA4A; TUBB2A; TUBB2B; TUBB3; TUBB6"
"R-HSA-195721","Signaling by WNT",-0.118986690518842,0.0299555475584168,7.12392023922007e-05,32,"AGO2; AKT1; AKT2; AP2A2; AP2B1; AP2M1; ARRB2; ASH2L; AXIN1; BTRC; CALM1; CAV1; CBY1; CCDC88C; CLTA; CSNK2A2; CTBP2; CTNNBIP1; CUL3; DAAM1; DACT1; DKK1; DVL1; DVL2; FRAT1; FRAT2; FZD1; FZD3; FZD6; FZD8; GNAO1; GNB2"
"R-HSA-176408","Regulation of APC/C activators between G1/S and early anaphase",0.0814689512684471,0.0205119845078762,7.1339610173998e-05,30,"ANAPC16; ANAPC4; ANAPC5; BTRC; BUB3; CCNA1; CCNA2; CDC16; CDK2; PLK1; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2"
"R-HSA-5223345","Miscellaneous transport and binding events",-0.248712722682151,0.0629881844416977,7.86222048881212e-05,16,"ADD1; ADD2; ANKH; AZGP1; CTNS; DMTN; LRRC8A; LRRC8B; LRRC8C; LRRC8D; MRS2; NIPA1; NIPAL1; NIPAL2; NIPAL3; NIPAL4"
"R-HSA-264870","Caspase-mediated cleavage of cytoskeletal proteins",-0.209342418282667,0.0531867490186037,8.28550327789714e-05,10,"ADD1; CASP3; CASP7; CASP8; DBNL; GAS2; GSN; MAPT; PLEC; VIM"
"R-HSA-8854214","TBC/RABGAPs",-0.210978726611891,0.0539959919629961,9.33319022501961e-05,24,"ARF6; GGA2; MAP1LC3B; OPTN; POLG; RAB11A; RAB33B; RAB5A; RAB5C; RAB6A; RAB6B; RAB8A; RABEP1; RABGAP1; TBC1D10A; TBC1D10C; TBC1D14; TBC1D15; TBC1D16; TBC1D2; TBC1D24; TBC1D7; TSC1; ULK1"
"R-HSA-72163","mRNA Splicing - Major Pathway",0.211837920746212,0.0542187071790903,9.3410430267134e-05,32,"AQR; BCAS2; CASC3; CCAR1; CDC40; CHERP; CPSF1; CPSF2; CPSF3; CPSF4; CPSF7; CSTF1; CSTF2T; CTNNBL1; CWC15; CWC25; DDX23; DDX5; DHX38; ELAVL1; ELAVL2; FUS; GCFC2; GTF2F2; HNRNPD; HNRNPF; HNRNPK; HSPA8; ISY1; LSM5; LSM6; LSM7"
"R-HSA-72172","mRNA Splicing",0.211837920746212,0.0542187071790903,9.3410430267134e-05,32,"AQR; BCAS2; CASC3; CCAR1; CDC40; CHERP; CPSF1; CPSF2; CPSF3; CPSF4; CPSF7; CSTF1; CSTF2T; CTNNBL1; CWC15; CWC25; DDX23; DDX5; DHX38; ELAVL1; ELAVL2; FUS; GCFC2; GTF2F2; HNRNPD; HNRNPF; HNRNPK; HSPA8; ISY1; LSM5; LSM6; LSM7"
"R-HSA-5654689","PI-3K cascade:FGFR1",-0.127835127633737,0.0328949150689347,0.000101839534818041,12,"FGF1; FGF10; FGF17; FGF5; FGF9; FGFR1; GAB1; GRB2; KL; PIK3CA; PIK3R1; PTPN11"
"R-HSA-2467813","Separation of Sister Chromatids",-0.136034976262135,0.0350167805975215,0.000102392651546542,26,"ANAPC16; ANAPC4; ANAPC5; BUB3; CDC16; CENPC; CENPE; CENPH; CENPL; CENPN; CENPP; CENPQ; CENPT; CKAP5; CLIP1; DSN1; DYNC1H1; DYNC1LI2; DYNLL2; INCENP; ITGB3BP; KIF2A; MAD1L1; MAPRE1; MIS12; NDE1"
"R-HSA-190236","Signaling by FGFR",0.0990837545488198,0.0255190236758034,0.000103285647363886,32,"CBL; FGF1; FGF10; FGF17; FGF5; FGF9; FGFR1; FGFR2; FLRT1; FLRT2; GAB1; GALNT3; GRB2; GTF2F2; HNRNPF; KL; KLB; KRAS; MAPK1; MAPK3; MKNK1; NCBP1; NCBP2; PIK3CA; PIK3R1; PLCG1; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I"
"R-HSA-196299","Beta-catenin phosphorylation cascade",0.213627941449624,0.0550357615640052,0.000103762706235258,11,"AXIN1; FRAT1; FRAT2; GSK3B; PPP2CA; PPP2R1A; PPP2R1B; PPP2R5A; PPP2R5C; PPP2R5D; PPP2R5E"
"R-HSA-112040","G-protein mediated events",-0.12374300128062,0.0319748223479208,0.000108829227101956,23,"ADCY3; ADCY6; ADCY7; AHCYL1; CALM1; CAMK4; CREB1; GNAI2; GNAO1; GNAZ; ITPR2; ITPR3; MAPK1; PDE1B; PDE1C; PLCB1; PLCB3; PRKACA; PRKAR1A; PRKAR1B; PRKAR2A; PRKCA; PRKCD"
"R-HSA-112043","PLC beta mediated events",-0.12374300128062,0.0319748223479208,0.000108829227101956,23,"ADCY3; ADCY6; ADCY7; AHCYL1; CALM1; CAMK4; CREB1; GNAI2; GNAO1; GNAZ; ITPR2; ITPR3; MAPK1; PDE1B; PDE1C; PLCB1; PLCB3; PRKACA; PRKAR1A; PRKAR1B; PRKAR2A; PRKCA; PRKCD"
"R-HSA-5654726","Negative regulation of FGFR1 signaling",-0.0989830287886871,0.0255934580955198,0.000109951023542578,19,"CBL; FGF1; FGF10; FGF17; FGF5; FGF9; FGFR1; GRB2; KL; MAPK1; MAPK3; MKNK1; PPP2CA; PPP2R1A; PTPN11; SPRY2; SRC; UBA52; UBC"
"R-HSA-6807505","RNA polymerase II transcribes snRNA genes",-0.10598118887017,0.0274849611530929,0.000115271569925373,41,"CCNK; CCNT1; CCNT2; CDK7; CDK9; ELL; GTF2A1; GTF2A2; GTF2E1; GTF2F2; INTS1; INTS10; INTS12; INTS2; INTS4; INTS6; INTS7; INTS8; INTS9; NCBP1; NCBP2; PCF11; PHAX; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L; POU2F1; RPAP2; RPRD1A; RPRD2; SNAPC1; SNAPC2; SNAPC3; SNAPC4; SNAPC5; SRRT"
"R-HSA-418885","DCC mediated attractive signaling",0.283685822440864,0.0737316106810694,0.000119306493578128,10,"ABLIM1; ABLIM2; ABLIM3; DCC; DOCK1; FYN; NCK1; NTN1; SRC; TRIO"
"R-HSA-5654736","Signaling by FGFR1",-0.089174831894391,0.0232649020167734,0.000126579720647105,27,"CBL; FGF1; FGF10; FGF17; FGF5; FGF9; FGFR1; FLRT1; FLRT2; GAB1; GRB2; KL; KRAS; MAPK1; MAPK3; MKNK1; PIK3CA; PIK3R1; PLCG1; PPP2CA; PPP2R1A; PTPN11; SPRED2; SPRY2; SRC; UBA52; UBC"
"R-HSA-2408557","Selenocysteine synthesis",0.167639961397548,0.0437663731556113,0.000127967844609561,33,"EEFSEC; PSTK; RPL10A; RPL12; RPL13; RPL14; RPL15; RPL17; RPL23; RPL26; RPL26L1; RPL27; RPL27A; RPL29; RPL3; RPL31; RPL35; RPL36; RPL36AL; RPL37A; RPL4; RPL6; RPL7; RPL8; RPL9; RPLP0; RPS12; RPS13; RPS14; RPS15; RPS19; RPS2; RPS20"
"R-HSA-176814","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins",0.0781209870898147,0.0204123187108157,0.000129635998971702,31,"ANAPC16; ANAPC4; ANAPC5; BUB3; CCNA1; CCNA2; CDC16; NEK2; PLK1; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1"
"R-HSA-5654741","Signaling by FGFR3",-0.0912172000371913,0.0238943501630015,0.000134798939203644,22,"CBL; FGF1; FGF17; FGF5; FGF9; GAB1; GALNT3; GRB2; KRAS; MAPK1; MAPK3; MKNK1; PIK3CA; PIK3R1; PLCG1; PPP2CA; PPP2R1A; PTPN11; SPRY2; SRC; UBA52; UBC"
"R-HSA-5654695","PI-3K cascade:FGFR2",-0.127303752803834,0.0334870255544875,0.000143773766055839,11,"FGF1; FGF10; FGF17; FGF5; FGF9; FGFR2; GAB1; GRB2; PIK3CA; PIK3R1; PTPN11"
"R-HSA-8874081","MET activates PTK2 signaling",0.298341414508929,0.0787261866965862,0.000150884988105194,10,"ITGA2; ITGA3; LAMA1; LAMA2; LAMA5; LAMB3; LAMC1; LAMC3; MET; SRC"
"R-HSA-5654727","Negative regulation of FGFR2 signaling",-0.0979473232522802,0.0258481209647644,0.000151047954393775,18,"CBL; FGF1; FGF10; FGF17; FGF5; FGF9; FGFR2; GRB2; MAPK1; MAPK3; MKNK1; PPP2CA; PPP2R1A; PTPN11; SPRY2; SRC; UBA52; UBC"
"R-HSA-69618","Mitotic Spindle Checkpoint",-0.131850624046323,0.0348595444462612,0.000155361408150582,29,"ANAPC16; ANAPC4; ANAPC5; BUB3; CDC16; CENPC; CENPE; CENPH; CENPL; CENPN; CENPP; CENPQ; CENPT; CKAP5; CLIP1; DSN1; DYNC1H1; DYNC1LI2; DYNLL2; INCENP; ITGB3BP; KIF2A; MAD1L1; MAPRE1; MIS12; NDE1; NDEL1; NSL1; NUDC"
"R-HSA-5696395","Formation of Incision Complex in GG-NER",-0.105289097814631,0.0278463581962247,0.000156154218149275,24,"CDK7; CHD1L; CUL4A; ERCC1; ERCC2; ERCC3; ERCC4; ERCC5; GTF2H1; GTF2H2; GTF2H3; GTF2H4; PARP1; PARP2; RAD23A; RAD23B; RPA1; RPA2; RPA3; UBA52; UBC; UBE2I; UBE2N; USP45"
"R-HSA-167287","HIV elongation arrest and recovery",-0.110855533047879,0.0296285130795512,0.000182914087516478,19,"CCNK; CCNT1; CCNT2; CDK9; ELL; GTF2F2; NELFA; NELFB; NELFCD; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L; SUPT16H; SUPT5H"
"R-HSA-167290","Pausing and recovery of HIV elongation",-0.110855533047879,0.0296285130795512,0.000182914087516478,19,"CCNK; CCNT1; CCNT2; CDK9; ELL; GTF2F2; NELFA; NELFB; NELFCD; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L; SUPT16H; SUPT5H"
"R-HSA-5218920","VEGFR2 mediated vascular permeability",0.152838045057668,0.0410640720016274,0.000197697378057722,19,"AKT1; AKT2; AKT3; CALM1; CAV1; CTNNA1; HSP90AA1; JUP; MLST8; MTOR; NOS3; PAK1; PAK2; PRR5; RICTOR; THEM4; TRIB3; VAV2; VAV3"
"R-HSA-418457","cGMP effects",-0.221916757786698,0.0597699142741366,0.000204937932345039,12,"KCNMA1; KCNMB4; MRVI1; PDE10A; PDE1B; PDE2A; PDE3A; PDE3B; PDE5A; PDE9A; PRKG1; PRKG2"
"R-HSA-1912420","Pre-NOTCH Processing in Golgi",0.325525694375659,0.0881426831633721,0.000221478021324411,11,"ATP2A2; FURIN; LFNG; NOTCH1; NOTCH3; RAB6A; RFNG; ST3GAL3; ST3GAL4; ST3GAL6; TMED2"
"R-HSA-1474290","Collagen formation",-0.16619623075523,0.0450449450361126,0.000224638258154715,32,"ADAMTS14; ADAMTS2; ADAMTS3; BMP1; CD151; COL11A2; COL12A1; COL14A1; COL15A1; COL16A1; COL18A1; COL19A1; COL22A1; COL23A1; COL24A1; COL26A1; COL27A1; COL28A1; COL4A4; COL5A2; COL5A3; COL6A1; COL6A2; COL6A3; COL8A1; COLGALT2; CRTAP; CTSB; CTSS; ITGA6; LAMB3; LOX"
"R-HSA-194138","Signaling by VEGF",0.10546876077703,0.02867245978626,0.000234702168112518,43,"ABI2; AHCYL1; AKT1; AKT2; AKT3; AXL; BCAR1; BRK1; CALM1; CAV1; CRK; CTNNA1; CYFIP1; CYFIP2; DOCK1; ELMO1; ELMO2; FLT1; FYN; HSP90AA1; ITGAV; ITGB3; ITPR2; ITPR3; JUP; KDR; KRAS; MAPK11; MAPK12; MAPK13; MAPK14; MLST8; MTOR; NCK1; NOS3; NRP1; NRP2; PAK1; PAK2; PGF; PIK3CA; PIK3CB; PIK3R1"
"R-HSA-6804115","TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain",-0.196180375478415,0.053924626139309,0.000274712289977101,11,"CENPJ; CNOT11; CNOT2; CNOT4; CNOT6L; CNOT7; CNOT8; NPM1; PLAGL1; TNKS1BP1; TP53"
"R-HSA-3371556","Cellular response to heat stress",0.124481139782723,0.0342591915351872,0.000279590822559268,32,"AAAS; ATM; BAG2; BAG4; BAG5; CAMK2B; CAMK2D; DNAJC7; EEF1A1; GSK3B; HSBP1; HSF1; HSP90AA1; HSP90AB1; HSPA12B; HSPA2; HSPA4; HSPA5; HSPA6; HSPA8; HSPA9; HSPB8; HSPH1; MAPK1; MAPK3; MLST8; MRPL18; MTOR; NDC1; NUP107; NUP205; NUP214"
"R-HSA-8856825","Cargo recognition for clathrin-mediated endocytosis",-0.117136010652227,0.0322387625261116,0.000279721281490945,35,"ADRB2; AP2A2; AP2B1; AP2M1; APOB; ARRB1; ARRB2; CBL; CD4; CFTR; CLTA; CLTCL1; COPS2; COPS3; COPS6; COPS7A; DAB2; DVL2; EGF; EGFR; EPN2; EPS15; FCHO1; GRB2; IL7R; ITSN1; KIAA0319; LDLRAP1; LRP2; M6PR; NECAP1; REPS1; SCARB2; SGIP1; SH3GL2"
"R-HSA-1430728","Metabolism",0.195448726397204,0.0538485537319848,0.000283860427053258,39,"AAAS; AADAT; AASS; ABCA1; ABCC1; ABCC5; ABCC8; ABCD4; ABHD10; ABHD14B; ABHD4; ABHD5; ACAA2; ACACA; ACACB; ACAD8; ACAD9; ACADL; ACADM; ACADS; ACADSB; ACADVL; ACAN; ACAT1; ACBD4; ACBD5; ACBD6; ACBD7; ACER2; ACHE; ACLY; ACOT1; ACOT11; ACOT2; ACOT4; ACOT8; ACOX2; ACOX3; ACP6"
"R-HSA-1650814","Collagen biosynthesis and modifying enzymes",-0.169606354423883,0.0467839921729715,0.00028861789880918,33,"ADAMTS14; ADAMTS2; ADAMTS3; BMP1; COL11A2; COL12A1; COL14A1; COL15A1; COL16A1; COL18A1; COL19A1; COL22A1; COL23A1; COL24A1; COL26A1; COL27A1; COL28A1; COL4A4; COL5A2; COL5A3; COL6A1; COL6A2; COL6A3; COL8A1; COLGALT2; CRTAP; P4HB; PCOLCE2; PLOD1; PLOD3; PPIB; TLL1; TLL2"
"R-HSA-500792","GPCR ligand binding",0.228314384626275,0.0631310428555853,0.000298595635472449,19,"ACKR3; ACKR4; ADCYAP1; ADCYAP1R1; ADM; ADORA2B; ADRA1A; ADRA1B; ADRA2C; ADRB2; AGT; ANXA1; APLNR; APP; C5; CALCRL; CCKBR; CCR1; CCR6"
"R-HSA-73884","Base Excision Repair",-0.124691505161745,0.0346569710891611,0.000320825766305943,23,"FEN1; LIG1; LIG3; NEIL1; NEIL2; OGG1; PARP1; PARP2; PNKP; POLD2; POLD3; POLE; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3; TDG; UNG; XRCC1"
"R-HSA-73933","Resolution of Abasic Sites (AP sites)",-0.124691505161745,0.0346569710891611,0.000320825766305943,23,"FEN1; LIG1; LIG3; NEIL1; NEIL2; OGG1; PARP1; PARP2; PNKP; POLD2; POLD3; POLE; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3; TDG; UNG; XRCC1"
"R-HSA-2022090","Assembly of collagen fibrils and other multimeric structures",-0.182849968581272,0.0509508197790913,0.000332261919693886,23,"BMP1; CD151; COL11A2; COL15A1; COL18A1; COL24A1; COL27A1; COL4A4; COL5A2; COL5A3; COL6A1; COL6A2; COL6A3; COL8A1; CTSB; CTSS; ITGA6; LAMB3; LOX; PLEC; PXDN; TLL1; TLL2"
"R-HSA-432142","Platelet sensitization by LDL",0.174472898025076,0.0487271817690194,0.000342796660808447,12,"APOB; FGR; LRP8; MAPK14; PPP2CA; PPP2R1A; PPP2R1B; PPP2R5A; PPP2R5C; PPP2R5D; PPP2R5E; PTPN11"
"R-HSA-422475","Axon guidance",-0.123296663748131,0.0344473296122319,0.000344541171852676,36,"ABL2; ABLIM1; ABLIM2; ABLIM3; ACTB; ACTG1; ACTR2; ADAM10; AKAP5; ALCAM; ANK1; AP2A2; AP2B1; AP2M1; ARHGAP39; ARHGEF11; ARHGEF12; ARHGEF28; ARPC1A; ARPC1B; ARPC2; ARPC3; ARPC4; CACNA1C; CACNA1D; CACNA1G; CACNA1I; CACNB3; CASC3; CDK5; CDK5R1; CFL1; CHL1; CLTA; CLTCL1; CNTN2"
"R-HSA-5651801","PCNA-Dependent Long Patch Base Excision Repair",-0.129323761208723,0.0361364025313056,0.000345219201784101,13,"FEN1; LIG1; POLD2; POLD3; POLE; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3"
"R-HSA-3214847","HATs acetylate histones",0.136160299778157,0.0382792078558214,0.000375070999388631,24,"ACTB; ACTL6A; ATXN7L3; BRPF1; CLOCK; DMAP1; DR1; ELP3; ELP4; EP400; HAT1; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; HIST2H2BF; KANSL1; KANSL2; KAT2B; KAT6A"
"R-HSA-72689","Formation of a pool of free 40S subunits",0.153575216434351,0.0431943329144468,0.000377335178300961,32,"EIF3A; EIF3B; EIF3C; EIF3E; EIF3F; EIF3H; EIF3I; EIF3L; RPL10A; RPL12; RPL13; RPL14; RPL15; RPL17; RPL23; RPL26; RPL26L1; RPL27; RPL27A; RPL29; RPL3; RPL31; RPL35; RPL36; RPL36AL; RPL37A; RPL4; RPL6; RPL7; RPL8; RPL9; RPLP0"
"R-HSA-174417","Telomere C-strand (Lagging Strand) Synthesis",-0.122863752709085,0.0345701066013504,0.000379352704286136,16,"DNA2; FEN1; LIG1; POLA2; POLD2; POLD3; POLE; PRIM1; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3"
"R-HSA-111447","Activation of BAD and translocation to mitochondria ",0.196025192347084,0.0553852438857501,0.000401184190321687,11,"AKT1; AKT2; AKT3; BCL2; BID; PPP3CC; PPP3R1; YWHAE; YWHAG; YWHAQ; YWHAZ"
"R-HSA-72695","Formation of the ternary complex, and subsequently, the 43S complex",-0.157320878359686,0.0444601212605755,0.000402450504289017,29,"EIF2S1; EIF3A; EIF3B; EIF3C; EIF3E; EIF3F; EIF3H; EIF3I; EIF3L; RPS12; RPS13; RPS14; RPS15; RPS19; RPS2; RPS20; RPS23; RPS24; RPS25; RPS26; RPS27; RPS27L; RPS28; RPS3; RPS5; RPS7; RPS8; RPS9; RPSA"
"R-HSA-3214858","RMTs methylate histone arginines",-0.141128347906766,0.0399636188209662,0.000413333888254762,21,"ACTL6A; ACTL6B; ARID1A; CARM1; H2AFV; H2AFZ; HIST1H2AB; HIST1H2AC; JAK2; PBRM1; PRMT1; PRMT6; PRMT7; RPS2; SMARCA4; SMARCC1; SMARCD2; SMARCD3; SMARCE1; WDR5; WDR77"
"R-HSA-1852241","Organelle biogenesis and maintenance",0.1616867186164,0.0459476919700526,0.00043329077064994,33,"ACSS2; AHI1; ALMS1; ARF4; ARL3; ASAP1; BBS1; BBS10; BBS12; BBS2; BBS4; BBS5; BBS7; BBS9; C2CD3; CALM1; CAMK4; CARM1; CC2D2A; CCT3; CCT4; CCT5; CCT8; CDK5RAP2; CENPJ; CEP135; CEP164; CEP192; CEP250; CEP290; CEP41; CEP57; CEP63"
"R-HSA-72203","Processing of Capped Intron-Containing Pre-mRNA",0.165002874853328,0.0470134110272558,0.000448615902221277,34,"AAAS; AQR; BCAS2; CASC3; CCAR1; CDC40; CHERP; CHTOP; CPSF1; CPSF2; CPSF3; CPSF4; CPSF7; CSTF1; CSTF2T; CTNNBL1; CWC15; CWC25; DDX23; DDX39B; DDX5; DHX38; EIF4E; ELAVL1; ELAVL2; FUS; FYTTD1; GCFC2; GLE1; GTF2F2; HNRNPD; HNRNPF; HNRNPK; HSPA8"
"R-HSA-69186","Lagging Strand Synthesis",-0.124144749270316,0.0354792067625555,0.000466858266264012,15,"DNA2; FEN1; LIG1; POLA2; POLD2; POLD3; PRIM1; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3"
"R-HSA-446652","Interleukin-1 family signaling",0.104096388552109,0.0298915573974524,0.000496814815188762,28,"ALOX5; APP; BTRC; IL18BP; IL18R1; IL1R1; IL1RAP; IL1RL1; IL1RL2; IL33; IRAK2; MAP2K6; MAP3K3; MAP3K7; MAP3K8; MAPK8; NFKB1; NFKBIA; NFKBIB; NKIRAS1; NOD1; PELI2; PELI3; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10"
"R-HSA-69304","Regulation of DNA replication",0.0703229352398979,0.0202068805218883,0.000501136827792146,35,"CCNA1; CCNA2; CDK2; CDKN1A; CDKN1B; E2F1; MCM2; MCM3; MCM4; MCM6; MCM7; MCM8; ORC2; ORC4; ORC5; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2"
"R-HSA-1500620","Meiosis",-0.0927372161731523,0.0266514268381999,0.000502098838660541,33,"ACD; ATM; BLM; BRCA2; CDK2; DIDO1; DMC1; H2AFV; H2AFZ; H3F3A; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; HSPA2; LMNB1; MLH1; MLH3; MSH4; NBN; POT1; PSMC3IP; RAD21; RAD50; RAD51C; RPA1; RPA2; RPA3; SMC3"
"R-HSA-3781865","Diseases of glycosylation",0.193136120493847,0.056606132769516,0.000645048513491747,27,"ACAN; ADAMTS1; ADAMTS13; ADAMTS14; ADAMTS17; ADAMTS18; ADAMTS19; ADAMTS2; ADAMTS3; ADAMTS5; ADAMTS6; ADAMTS8; ADAMTS9; ADAMTSL1; ADAMTSL2; ADAMTSL3; DAG1; DCN; FMOD; GPC5; HSPG2; LUM; MUC12; MUC20; NCAN; NOTCH1; NOTCH3"
"R-HSA-375276","Peptide ligand-binding receptors",0.276507096928378,0.0812733767017116,0.000668492672482557,13,"ACKR3; ACKR4; AGT; ANXA1; APLNR; APP; C5; CCKBR; CCR1; CCR6; CORT; CX3CL1; CXCL5"
"R-HSA-76002","Platelet activation, signaling and aggregation",0.125649783789476,0.0369830611546072,0.00068005706843254,32,"A2M; ABCC4; ABHD12; ABHD6; ADRA2C; AKT1; AKT2; AKT3; ANXA5; APLP2; APP; ARRB1; ARRB2; BCAR1; CALM1; CALU; CD109; CD36; CD9; CDC37L1; CFL1; CHID1; CLEC3B; CRK; DAGLB; DGKA; DGKE; DGKG; DGKQ; EGF; ENDOD1; F2R"
"R-HSA-5689603","UCH proteinases",-0.0734370046683838,0.021764084234703,0.000740227546633884,31,"ACTB; ACTL6A; ACTR8; ASXL1; ASXL2; BAP1; BARD1; FOXK1; FOXK2; HIST1H2AB; HIST1H2AC; INO80D; INO80E; KDM1B; MBD5; NFRKB; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2"
"R-HSA-199977","ER to Golgi Anterograde Transport",0.149277381973965,0.0443338718396027,0.00075958153807287,40,"ACTR10; ANK1; ANKRD28; ARF1; ARF3; ARF4; ARFGAP3; BET1; CAPZA2; CAPZB; CD55; CD59; CNIH3; COG1; COG2; COG3; COG4; COG6; COG7; COG8; COPA; COPE; COPG2; COPZ1; COPZ2; CSNK1D; CTSC; CTSZ; DCTN3; DCTN5; DCTN6; DYNC1H1; DYNC1LI2; DYNLL2; F5; GBF1; GOLGA2; GOLGB1; GORASP1; GOSR1"
"R-HSA-3247509","Chromatin modifying enzymes",0.134171003399799,0.0398512032348646,0.000760460093638962,33,"ACTB; ACTL6A; ACTL6B; AEBP2; ARID1A; ARID4A; ARID4B; ARID5B; ASH1L; ASH2L; ATXN7L3; BRMS1; BRPF1; BRWD1; CARM1; CLOCK; DMAP1; DPY30; DR1; EHMT1; ELP3; ELP4; EP400; EZH2; GATAD2A; H2AFV; H2AFZ; HAT1; HDAC1; HDAC2; HDAC3; HIST1H2AB; HIST1H2AC"
"R-HSA-4839726","Chromatin organization",0.134171003399799,0.0398512032348646,0.000760460093638962,33,"ACTB; ACTL6A; ACTL6B; AEBP2; ARID1A; ARID4A; ARID4B; ARID5B; ASH1L; ASH2L; ATXN7L3; BRMS1; BRPF1; BRWD1; CARM1; CLOCK; DMAP1; DPY30; DR1; EHMT1; ELP3; ELP4; EP400; EZH2; GATAD2A; H2AFV; H2AFZ; HAT1; HDAC1; HDAC2; HDAC3; HIST1H2AB; HIST1H2AC"
"R-HSA-3108214","SUMOylation of DNA damage response and repair proteins",-0.0873374683238854,0.0264957805785126,0.00097974885199696,36,"AAAS; BLM; CBX4; EID3; MDC1; NDC1; NSMCE1; NSMCE2; NSMCE4A; NUP107; NUP205; NUP214; NUP35; NUP37; NUP43; NUP50; NUP54; NUP62; NUP85; NUP88; NUP93; PARP1; PHC2; PIAS2; PML; POM121; POM121C; RAD21; RAD52; RAE1; RANBP2; RNF2; RPA1; SEH1L; SMC3; SMC5"
"R-HSA-72766","Translation",-0.144361114434149,0.0438740869086287,0.00100062733440817,36,"AARS2; AIMP1; CARS; CARS2; DARS2; EARS2; EEF1A1; EEF1A1P5; EEF1A2; EEF2; EIF2B1; EIF2B2; EIF2B3; EIF2B4; EIF2B5; EIF2S1; EIF3A; EIF3B; EIF3C; EIF3E; EIF3F; EIF3H; EIF3I; EIF3L; EIF4A1; EIF4A2; EIF4B; EIF4E; EIF4EBP1; ETF1; FARS2; FARSA; FARSB; GARS; GFM1; GFM2"
"R-HSA-68949","Orc1 removal from chromatin",0.0649126739489593,0.0197692832116768,0.00102522366524414,37,"CCNA1; CCNA2; CDK2; CDKN1A; CDKN1B; MCM2; MCM3; MCM4; MCM6; MCM7; MCM8; ORC2; ORC4; ORC5; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; RB1"
"R-HSA-69052","Switching of origins to a post-replicative state",0.0649126739489593,0.0197692832116768,0.00102522366524414,37,"CCNA1; CCNA2; CDK2; CDKN1A; CDKN1B; MCM2; MCM3; MCM4; MCM6; MCM7; MCM8; ORC2; ORC4; ORC5; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; RB1"
"R-HSA-69300","Removal of licensing factors from origins",0.0649126739489593,0.0197692832116768,0.00102522366524414,37,"CCNA1; CCNA2; CDK2; CDKN1A; CDKN1B; MCM2; MCM3; MCM4; MCM6; MCM7; MCM8; ORC2; ORC4; ORC5; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; RB1"
"R-HSA-69656","Cyclin A:Cdk2-associated events at S phase entry",0.0649545695678991,0.0197984648199685,0.00103517450350963,37,"CCNA1; CCNA2; CDC25A; CDC25B; CDK2; CDK7; CDKN1A; CDKN1B; CKS1B; E2F1; E2F5; LIN52; LIN54; LIN9; MAX; MYC; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSMF1"
"R-HSA-373760","L1CAM interactions",-0.107607996968067,0.0329561893612841,0.00109393285480266,33,"ALCAM; ANK1; AP2A2; AP2B1; AP2M1; CHL1; CLTA; CNTN2; CSNK2A2; DNM2; DNM3; EGFR; EPHB2; FGFR1; GAP43; HSPA8; ITGA1; ITGA2; ITGA9; ITGAV; ITGB3; KCNQ2; KCNQ3; LAMA1; LAMC1; MAPK1; MAPK3; NCAN; NRP1; NRP2; NUMB; PAK1; RANBP9"
"R-HSA-888590","GABA synthesis, release, reuptake and degradation",0.376002506632559,0.115378154193348,0.00111856565106344,10,"ABAT; ALDH5A1; CPLX1; DNAJC5; GAD1; GAD2; HSPA8; SLC6A13; SYT1; VAMP2"
"R-HSA-1169408","ISG15 antiviral mechanism",-0.0793862266289931,0.0244473114093837,0.00116531099523439,37,"AAAS; DDX58; EIF4A1; EIF4A2; EIF4E; EIF4E3; FLNB; HERC5; JAK1; KPNA3; KPNA4; KPNA5; MAPK3; MX1; MX2; NDC1; NEDD4; NUP107; NUP205; NUP214; NUP35; NUP37; NUP43; NUP50; NUP54; NUP62; NUP85; NUP88; NUP93; PLCG1; POM121; POM121C; RAE1; RANBP2; SEH1L; TRIM25; UBA52"
"R-HSA-1169410","Antiviral mechanism by IFN-stimulated genes",-0.0793862266289931,0.0244473114093837,0.00116531099523439,37,"AAAS; DDX58; EIF4A1; EIF4A2; EIF4E; EIF4E3; FLNB; HERC5; JAK1; KPNA3; KPNA4; KPNA5; MAPK3; MX1; MX2; NDC1; NEDD4; NUP107; NUP205; NUP214; NUP35; NUP37; NUP43; NUP50; NUP54; NUP62; NUP85; NUP88; NUP93; PLCG1; POM121; POM121C; RAE1; RANBP2; SEH1L; TRIM25; UBA52"
"R-HSA-1566948","Elastic fibre formation",0.263126324232823,0.0813970051868455,0.00122656717711015,19,"BMP2; BMP4; EFEMP1; FBLN1; FBLN2; FBN2; FURIN; ITGA8; ITGAV; ITGB3; ITGB5; LOX; LTBP1; LTBP2; LTBP4; MFAP3; TGFB1; TGFB2; TGFB3"
"R-HSA-166658","Complement cascade",0.433118300766002,0.13419199613901,0.00124832703568279,11,"C1QA; C1QC; C1R; C5; C7; CD46; CD55; CD59; CD81; CFH; CR1"
"R-HSA-977606","Regulation of Complement cascade",0.433118300766002,0.13419199613901,0.00124832703568279,11,"C1QA; C1QC; C1R; C5; C7; CD46; CD55; CD59; CD81; CFH; CR1"
"R-HSA-983189","Kinesins",0.311418131315028,0.0966060911138303,0.0012659587368395,20,"CENPE; KIF13B; KIF15; KIF16B; KIF19; KIF20B; KIF21A; KIF21B; KIF22; KIF27; KIF2A; KIF3B; KIF5A; KIF5C; KIF6; KIF9; KIFAP3; KIFC2; KLC1; KLC2"
"R-HSA-1912408","Pre-NOTCH Transcription and Translation",0.191664208080911,0.0597091760041618,0.00132752350320811,11,"AGO2; E2F1; JUN; KAT2B; MAML1; NOTCH1; NOTCH3; RBPJ; SNW1; TFDP1; TP53"
"R-HSA-392518","Signal amplification",0.141501239787428,0.0441609620982654,0.00135431059450248,15,"GNA13; GNA15; GNAI2; GNB2; GNB3; GNB4; GNB5; GNG11; GNG4; GNG5; GNG7; MAPK14; P2RY1; P2RY12; SRC"
"R-HSA-1640170","Cell Cycle",0.0985651894949124,0.0309708856157014,0.00146003882659355,32,"AAAS; ACD; AJUBA; AKT1; AKT2; AKT3; ALMS1; ANAPC16; ANAPC4; ANAPC5; ANKLE2; ARPP19; ATM; ATRIP; BANF1; BARD1; BLM; BLZF1; BORA; BRCA2; BRIP1; BTRC; BUB3; CCNA1; CCNA2; CCND2; CCND3; CDC14A; CDC16; CDC25A; CDC25B; CDC7"
"R-HSA-418597","G alpha (z) signalling events",-0.111890496212901,0.0352772478051439,0.00151525079397263,19,"ADCY3; ADCY6; ADCY7; ADRA2C; GNAI2; GNAZ; GNB2; GNB3; GNB4; GNB5; GNG11; GNG4; GNG5; GNG7; PRKCA; PRKCB; PRKCD; PRKCQ; RGS4"
"R-HSA-176409","APC/C:Cdc20 mediated degradation of mitotic proteins",0.0647206976715609,0.0204431743198371,0.00154612978840817,30,"ANAPC16; ANAPC4; ANAPC5; BUB3; CCNA1; CCNA2; CDC16; NEK2; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1"
"R-HSA-3214815","HDACs deacetylate histones",0.111438244953184,0.0352735055936018,0.00158169242070828,28,"ARID4A; ARID4B; BRMS1; GATAD2A; HDAC1; HDAC2; HDAC3; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; HIST2H2BF; HMG20B; MBD3; MTA3; NCOR1; NCOR2; RBBP4; RCOR1; REST; SAP18; SAP30; SAP30L; SUDS3"
"R-HSA-5696399","Global Genome Nucleotide Excision Repair (GG-NER)",0.0950681568417348,0.0301365328353891,0.00160728335102157,39,"ACTB; ACTL6A; ACTR8; CDK7; CHD1L; COPS2; COPS3; COPS6; COPS7A; CUL4A; ERCC1; ERCC2; ERCC3; ERCC4; ERCC5; GTF2H1; GTF2H2; GTF2H3; GTF2H4; INO80D; INO80E; LIG1; LIG3; NFRKB; PARP1; PARP2; POLD2; POLD3; POLE; RAD23A; RAD23B; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3"
"R-HSA-4086400","PCP/CE pathway",-0.0621667892694219,0.0197151103986755,0.00161460169091431,37,"AP2A2; AP2B1; AP2M1; ARRB2; CLTA; DAAM1; DVL1; DVL2; FZD1; FZD3; FZD6; FZD8; PARD6A; PFN1; PRICKLE1; PRKCA; PRKCB; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2"
"R-HSA-73894","DNA Repair",0.102881658386501,0.0329550069872669,0.00179698665986413,41,"ACTB; ACTL6A; ACTR8; ALKBH2; ALKBH3; ALKBH5; AQR; ASCC1; ASCC2; ASCC3; ATM; ATRIP; BAP1; BARD1; BLM; BRCA2; BRIP1; CCNA1; CCNA2; CDK2; CDK7; CHD1L; CHEK1; COPS2; COPS3; COPS6; COPS7A; CUL4A; DCLRE1A; DCLRE1B; DNA2; ELL; EME2; ERCC1; ERCC2; ERCC3; ERCC4; ERCC5; ERCC6; ERCC8; EXO1"
"R-HSA-416476","G alpha (q) signalling events",0.150224024646292,0.048285043514216,0.00186333957646484,28,"ABHD12; ABHD6; ADRA1A; ADRA1B; AGT; ANXA1; APP; CCKBR; CHRM1; CHRM5; CREB1; CYSLTR2; DAGLB; DGKA; DGKE; DGKG; DGKQ; EDN1; EDN3; EDNRA; EGFR; F2R; F2RL1; FFAR4; GNA15; GNB2; GNB3; GNB4"
"R-HSA-389960","Formation of tubulin folding intermediates by CCT/TriC",-0.177145924313652,0.057069135737814,0.00190885714630352,12,"CCT3; CCT4; CCT5; CCT6B; CCT8; TUBA1A; TUBA1C; TUBA4A; TUBB2A; TUBB2B; TUBB3; TUBB6"
"R-HSA-111933","Calmodulin induced events",-0.120607558230549,0.0388633995294167,0.00191329439682671,14,"ADCY3; ADCY6; ADCY7; CALM1; CAMK4; CREB1; PDE1B; PDE1C; PRKACA; PRKAR1A; PRKAR1B; PRKAR2A; PRKCA; PRKCD"
"R-HSA-111997","CaM pathway",-0.120607558230549,0.0388633995294167,0.00191329439682671,14,"ADCY3; ADCY6; ADCY7; CALM1; CAMK4; CREB1; PDE1B; PDE1C; PRKACA; PRKAR1A; PRKAR1B; PRKAR2A; PRKCA; PRKCD"
"R-HSA-68962","Activation of the pre-replicative complex",-0.115107904595041,0.0371749207421493,0.00195895162721901,18,"CDC7; CDK2; DBF4; MCM2; MCM3; MCM4; MCM6; MCM7; MCM8; ORC2; ORC4; ORC5; POLA2; POLE; PRIM1; RPA1; RPA2; RPA3"
"R-HSA-68875","Mitotic Prophase",0.0912665228251408,0.0295342757035326,0.00200028505534952,32,"AAAS; ARPP19; BANF1; BLZF1; CNEP1R1; GOLGA2; GORASP1; H2AFV; H2AFZ; H3F3A; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; LEMD2; LEMD3; LMNB1; LPIN1; LPIN2; LPIN3; MAPK1; MAPK3; MASTL; MCPH1; NCAPG2; NDC1; NEK6; NUP107"
"R-HSA-3928664","Ephrin signaling",0.213768868852663,0.0692527193084708,0.00202327851517753,11,"EFNB2; EFNB3; EPHB1; EPHB2; EPHB4; FYN; GIT1; MYL12A; PAK1; PAK2; SRC"
"R-HSA-5358351","Signaling by Hedgehog",-0.101921649304928,0.0332814852019021,0.00219560369292634,40,"ADAM17; ADCY10; ADCY3; ADCY6; ADCY7; ARRB1; ARRB2; BOC; BTRC; CDON; CUL3; DISP2; DYNC2H1; DZIP1; EFCAB7; ERLEC1; EVC2; FUZ; GAS1; GAS8; GPC5; GPR161; GSK3B; HHAT; HHIP; IFT122; IFT52; IFT57; IFT88; INTU; IQCE; KIF7; MKS1; NUMB; P4HB; PRKACA; PRKAR1A; PRKAR1B; PRKAR2A; PSMA1"
"R-HSA-418592","ADP signalling through P2Y purinoceptor 1",0.139811110642191,0.0456820183538993,0.00220946868277816,12,"GNA15; GNB2; GNB3; GNB4; GNB5; GNG11; GNG4; GNG5; GNG7; MAPK14; P2RY1; SRC"
"R-HSA-8853659","RET signaling",0.121615331370572,0.0401385865957593,0.00244646268489629,19,"DOK4; DOK5; DOK6; GAB1; GFRA1; GFRA2; GRB2; PDLIM7; PIK3CA; PIK3CB; PIK3CD; PIK3R1; PLCG1; PRKACA; PRKCA; PTPN11; RET; SHC3; SRC"
"R-HSA-450302","activated TAK1 mediates p38 MAPK activation",-0.13157461371343,0.0434976549599807,0.00248742623214653,11,"IRAK2; MAP2K6; MAP3K7; MAPK11; MAPK14; NOD1; TAB1; TAB2; TRAF6; UBE2N; UBE2V1"
"R-HSA-8876725","Protein methylation",0.247235510024999,0.0818752995297434,0.0025305917116297,10,"CALM1; CAMKMT; EEF1A1; EEF2; ETFB; HSPA8; METTL21A; METTL22; RPS2; VCPKMT"
"R-HSA-3371511","HSF1 activation",-0.139828628096014,0.0463388483211389,0.00254848113283219,12,"EEF1A1; HSBP1; HSF1; HSP90AA1; HSP90AB1; HSPA6; HSPH1; MRPL18; RPA1; RPA2; RPA3; YWHAE"
"R-HSA-5357769","Caspase activation via extrinsic apoptotic signalling pathway",0.220231443862446,0.0731354872786106,0.00260148680350204,18,"APPL1; CASP3; CASP8; CASP9; CD14; DAPK2; DAPK3; DCC; FADD; FAS; TICAM1; TLR4; TNFRSF10A; TNFRSF10B; TNFSF10; TRADD; UNC5A; UNC5B"
"R-HSA-199418","Negative regulation of the PI3K/AKT network",0.0857098887897848,0.0285347747408719,0.00266718613492637,34,"AKT1; AKT2; AKT3; BTC; EGF; EGFR; ERBB2; ERBB3; ERBB4; ESR1; ESR2; FGF1; FGF10; FGF17; FGF5; FGF9; FGFR1; FGFR2; FYN; GAB1; GRB2; IL1RAP; IL1RL1; IL33; KIT; KITLG; KL; KLB; MAPK1; MAPK3; MET; NRG2; NRG4; PDGFA"
"R-HSA-69190","DNA strand elongation",-0.100325842401993,0.0335066185813754,0.00275156758771744,23,"DNA2; FEN1; GINS2; GINS4; LIG1; MCM2; MCM3; MCM4; MCM6; MCM7; MCM8; POLA2; POLD2; POLD3; PRIM1; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3"
"R-HSA-6785807","Interleukin-4 and 13 signaling",0.143813694939354,0.0484892958816817,0.00301812924786615,23,"AKT1; ALOX5; ANXA1; BCL2; BCL6; CCL2; CD36; CDKN1A; FOXO1; FSCN1; HIF1A; HMOX1; HSP90AA1; HSPA8; ICAM1; IL12A; IL4R; ITGAX; ITGB2; JAK1; JAK2; JAK3; LAMA5"
"R-HSA-432722","Golgi Associated Vesicle Biogenesis",-0.124252372535042,0.0421237763935607,0.00318085818448009,34,"ACBD3; AP1B1; AP1M1; AP1S1; AP3B1; AP4B1; AP4E1; ARF1; ARRB1; BLOC1S3; CLTA; CPD; DNAJC6; DNM2; DTNBP1; FTH1; FTL; GOLGB1; HIP1R; HSPA8; NAPA; NECAP1; PUM1; RAB5C; SH3D19; SH3GL2; SNAPIN; SNX9; SORT1; TPD52; TPD52L1; TXNDC5; VAMP2; VAMP8"
"R-HSA-389977","Post-chaperonin tubulin folding pathway",-0.198456004974131,0.0678051057385206,0.00342403734538766,11,"TBCA; TBCC; TBCD; TBCE; TUBA1A; TUBA1C; TUBA4A; TUBB2A; TUBB2B; TUBB3; TUBB6"
"R-HSA-162587","HIV Life Cycle",0.0851847687856592,0.0292823685623445,0.00362493452143919,41,"AAAS; BANF1; CCNK; CCNT1; CCNT2; CD4; CDK7; CDK9; CHMP2A; CHMP2B; CHMP3; CHMP4A; CHMP4B; CHMP7; ELL; ERCC2; ERCC3; FEN1; FURIN; GTF2A1; GTF2A2; GTF2E1; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; HMGA1; LIG1; LIG4; MVB12A; MVB12B; NCBP1; NCBP2; NDC1; NELFA; NELFB; NELFCD; NMT1; NMT2; NUP107"
"R-HSA-1980143","Signaling by NOTCH1",0.110854065196669,0.038113693952045,0.00363155403447616,28,"ADAM10; ADAM17; ARRB1; ARRB2; CDK8; DLL4; HDAC1; HDAC2; HDAC3; HDAC4; HDAC5; HES1; HEY2; HIF1A; JAG1; KAT2B; MAML1; MIB1; MYC; NCOR1; NCOR2; NOTCH1; NUMB; PSEN1; PSEN2; RBPJ; SKP1; SNW1"
"R-HSA-190828","Gap junction trafficking",-0.167503870096082,0.0576720264813025,0.00367932528814172,12,"AP2M1; CLTA; CLTCL1; DAB2; DNM2; GJA1; GJB2; GJB6; GJC1; GJC2; GJD2; MYO6"
"R-HSA-5675221","Negative regulation of MAPK pathway",0.091222286303789,0.0315522569361931,0.00383835695348951,19,"DUSP16; DUSP4; DUSP6; DUSP7; KRAS; KSR1; MAPK1; MAPK3; PEBP1; PPP2CA; PPP2R1A; PPP2R1B; PPP2R5A; PPP2R5C; PPP2R5D; PPP2R5E; PPP5C; UBA52; UBC"
"R-HSA-3906995","Diseases associated with O-glycosylation of proteins",0.178535498834194,0.062156481078047,0.00407424594099989,27,"ADAMTS1; ADAMTS13; ADAMTS14; ADAMTS17; ADAMTS18; ADAMTS19; ADAMTS2; ADAMTS3; ADAMTS5; ADAMTS6; ADAMTS8; ADAMTS9; ADAMTSL1; ADAMTSL2; ADAMTSL3; DAG1; MUC12; MUC20; NOTCH1; NOTCH3; SEMA5B; SPON1; SPON2; SSPO; THBS2; THSD1; THSD7A"
"R-HSA-69541","Stabilization of p53",-0.0541047582097152,0.0188423236999936,0.00408595622384504,28,"ATM; MDM2; MDM4; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; TP53; UBA52; UBC"
"R-HSA-2559580","Oxidative Stress Induced Senescence",0.0812544767867107,0.0284476923372549,0.00428641588274679,30,"CBX4; CDK6; CDKN2B; CDKN2C; E2F1; EZH2; H2AFV; H2AFZ; H3F3A; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; JUN; KDM6B; MAP2K6; MAP2K7; MAP3K5; MAP4K4; MAPK1; MAPK10; MAPK11; MAPK14; MAPK3; MAPK8; MAPKAPK5"
"R-HSA-5693532","DNA Double-Strand Break Repair",0.0869300381209108,0.0307677683580864,0.0047227444154058,30,"ATM; ATRIP; BAP1; BARD1; BLM; BRCA2; BRIP1; CCNA1; CCNA2; CDK2; CHEK1; DNA2; EME2; ERCC1; ERCC4; EXO1; EYA4; FEN1; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; LIG3; LIG4; MAPK8; MDC1; NBN; PALB2"
"R-HSA-72312","rRNA processing",-0.139302440207074,0.0493625732310151,0.00477213831994082,31,"BMS1; BYSL; C1D; CSNK1D; DCAF13; DDX47; DDX52; DHX37; DIMT1; EBNA1BP2; ELAC2; ERI1; EXOSC10; EXOSC2; EXOSC3; EXOSC4; EXOSC5; EXOSC6; EXOSC8; EXOSC9; FBL; FTSJ3; GAR1; GNL3; HEATR1; IMP4; ISG20L2; KRR1; LTV1; MPHOSPH10; MPHOSPH6"
"R-HSA-349425","Autodegradation of the E3 ubiquitin ligase COP1",-0.0534024751238315,0.0189649784350492,0.00486488488404031,26,"ATM; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; TP53; UBA52; UBC"
"R-HSA-163841","Gamma carboxylation, hypusine formation and arylsulfatase activation",0.317760568822757,0.112933156765131,0.00489741741797708,17,"ARSA; ARSB; DHPS; DOHH; DPH1; DPH3; EEF2; EIF5A; EIF5A2; F7; FN3KRP; FURIN; GGCX; ICMT; PROS1; SUMF1; SUMF2"
"R-HSA-5668541","TNFR2 non-canonical NF-kB pathway",0.0590390386209526,0.0210335941480892,0.00500219246421711,26,"BIRC2; BTRC; LTBR; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; SKP1"
"R-HSA-15869","Metabolism of nucleotides",-0.174921232290386,0.0624900128156838,0.00512314564426133,36,"ADA; ADAL; ADK; ADPRM; ADSSL1; AK5; AK7; AK8; AK9; AMPD3; APRT; ATIC; CMPK1; CTPS1; DCK; DCTD; DHODH; DNPH1; DTYMK; DUT; ENTPD1; ENTPD5; ENTPD6; GART; GDA; GLRX; GPX1; GUK1; IMPDH1; ITPA; LHPP; NME1; NME6; NME7; NT5C; NT5C1A"
"R-HSA-389357","CD28 dependent PI3K/Akt signaling",0.116733237405845,0.0417390163757823,0.00516208232233117,13,"AKT1; AKT2; AKT3; FYN; MAP3K8; MLST8; MTOR; PIK3CA; PIK3R1; PRR5; RICTOR; THEM4; TRIB3"
"R-HSA-912446","Meiotic recombination",-0.0772427494207521,0.0276492388219419,0.00521142097277438,28,"ATM; BLM; BRCA2; CDK2; DMC1; H2AFV; H2AFZ; H3F3A; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; MLH1; MLH3; MSH4; NBN; PSMC3IP; RAD50; RAD51C; RPA1; RPA2; RPA3; TEX15; TOP3A"
"R-HSA-5607764","CLEC7A (Dectin-1) signaling",-0.0585077404569684,0.0210572993872802,0.00546102410038001,32,"AHCYL1; BTRC; CALM1; CARD11; CASP8; CLEC7A; ITPR2; ITPR3; MALT1; MAP3K7; NFATC1; NFKB1; NFKBIA; PLCG2; PPP3CB; PPP3R1; PRKCD; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2"
"R-HSA-390918","Peroxisomal lipid metabolism",-0.183057385720292,0.0661447574374501,0.00564834095022974,19,"ACBD4; ACBD5; ACOT4; ACOT8; ACOX2; ACOX3; ALDH3A2; AMACR; CRAT; ECI2; HACL1; HSD17B4; MLYCD; NUDT7; PECR; PHYH; SCP2; SLC25A17; SLC27A2"
"R-HSA-109581","Apoptosis",0.104684777472426,0.0381961109449436,0.00613050562203883,39,"ACIN1; ADD1; AKT1; AKT2; AKT3; APPL1; BAK1; BCL2; BCL2L11; BID; BIRC2; BMF; CASP3; CASP7; CASP8; CASP9; CD14; CDH1; CYCS; DAPK2; DAPK3; DBNL; DCC; DFFB; DNM1L; DSG2; DSP; DYNLL2; E2F1; FADD; FAS; GAS2; GSN; H1F0; HIST1H1A; HIST1H1C; HIST1H1D; HMGB2; LMNB1"
"R-HSA-110373","Resolution of AP sites via the multiple-nucleotide patch replacement pathway",-0.100818984303275,0.0371116312921173,0.00659480701307872,15,"FEN1; LIG1; PARP1; PARP2; POLD2; POLD3; POLE; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3"
"R-HSA-73857","RNA Polymerase II Transcription",-0.0885657668648245,0.0326939237109139,0.00674992348298308,30,"ACTL6A; ACTL6B; AFF4; AGO2; AIFM2; AKT1; AKT2; AKT3; APOE; ARID1A; ARID3A; ASH2L; ATAD2; ATM; ATRIP; AXIN1; BARD1; BCL2L11; BCL6; BID; BLM; BMP2; BRD7; BRIP1; BRPF1; CARM1; CASC3; CASP10; CBX3; CBX4"
"R-HSA-5357801","Programmed Cell Death",0.104796135150887,0.0387596432320866,0.00685631831745028,38,"ACIN1; ADD1; AKT1; AKT2; AKT3; APPL1; BAK1; BCL2; BCL2L11; BID; BIRC2; BMF; CASP3; CASP7; CASP8; CASP9; CD14; CDH1; CYCS; DAPK2; DAPK3; DBNL; DCC; DFFB; DNM1L; DSG2; DSP; DYNLL2; E2F1; FADD; FAS; GAS2; GSN; H1F0; HIST1H1A; HIST1H1C; HIST1H1D; HMGB2"
"R-HSA-8939243","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known",-0.159236987990673,0.0589040783071137,0.00686491639930852,14,"ACTL6A; ACTL6B; ARID1A; CBX4; CSNK2A2; PBRM1; PHC2; RNF2; RUNX1; SMARCA4; SMARCC1; SMARCD2; SMARCD3; SMARCE1"
"R-HSA-4551638","SUMOylation of chromatin organization proteins",0.0796294161210734,0.0294562489927631,0.00686523787881991,30,"AAAS; CBX4; HDAC1; HDAC2; HDAC4; L3MBTL2; NDC1; NUP107; NUP205; NUP214; NUP35; NUP37; NUP43; NUP50; NUP54; NUP62; NUP85; NUP88; NUP93; PHC2; PIAS2; POM121; POM121C; RAE1; RANBP2; RNF2; SATB1; SATB2; SEH1L; UBE2I"
"R-HSA-2299718","Condensation of Prophase Chromosomes",0.10039493991275,0.037158192762676,0.0068960015632639,16,"H2AFV; H2AFZ; H3F3A; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; MCPH1; NCAPG2; PLK1; RB1; SMC2"
"R-HSA-6811438","Intra-Golgi traffic",0.1976478198069,0.0737214661866548,0.00734008230815446,27,"ARF1; COG1; COG2; COG3; COG4; COG6; COG7; COG8; CYTH1; CYTH2; GOLGA5; GOLIM4; GOSR1; GOSR2; MAN2A1; MAN2A2; NAPA; NAPB; NAPG; NSF; RAB30; RAB33B; RAB36; RGP1; SNAP29; STX6; TRIP11"
"R-HSA-936837","Ion transport by P-type ATPases",-0.128588695438671,0.0482406978954181,0.00768591689351626,29,"ATP10B; ATP10D; ATP11A; ATP11B; ATP13A2; ATP13A5; ATP1A1; ATP1A3; ATP1B1; ATP1B2; ATP1B3; ATP2A2; ATP2B1; ATP2B4; ATP2C1; ATP2C2; ATP7B; ATP8A1; ATP8A2; ATP8B2; ATP8B4; ATP9A; ATP9B; CALM1; CAMK2B; CAMK2D; FXYD6; PLN; SRI"
"R-HSA-174084","Autodegradation of Cdh1 by Cdh1:APC/C",-0.0507438699572445,0.019103906155211,0.0079025817295556,28,"ANAPC16; ANAPC4; ANAPC5; CDC16; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSMF1; UBA52; UBC; UBE2E1"
"R-HSA-202131","Metabolism of nitric oxide",-0.124858155471994,0.047139563235963,0.00808040805763899,11,"AKT1; CALM1; CAV1; DDAH1; DDAH2; DNM2; HSP90AA1; NOS3; NOSIP; NOSTRIN; ZDHHC21"
"R-HSA-203765","eNOS activation and regulation",-0.124858155471994,0.047139563235963,0.00808040805763899,11,"AKT1; CALM1; CAV1; DDAH1; DDAH2; DNM2; HSP90AA1; NOS3; NOSIP; NOSTRIN; ZDHHC21"
"R-HSA-5173105","O-linked glycosylation",0.161094726467588,0.0608363267641498,0.00809690008252534,37,"ADAMTS1; ADAMTS13; ADAMTS14; ADAMTS17; ADAMTS18; ADAMTS19; ADAMTS2; ADAMTS3; ADAMTS5; ADAMTS6; ADAMTS8; ADAMTS9; ADAMTSL1; ADAMTSL2; ADAMTSL3; B3GALNT2; B3GNTL1; B4GALT5; B4GALT6; C1GALT1; DAG1; GALNT1; GALNT10; GALNT13; GALNT14; GALNT15; GALNT16; GALNT18; GALNT2; GALNT3; GALNT6; GALNT7; GALNT9; GALNTL5; GALNTL6; GCNT1; GCNT4"
"R-HSA-73777","RNA Polymerase I Chain Elongation",0.0680969805422841,0.0257425879244166,0.00816174637474741,35,"CBX3; CD3EAP; CDK7; ERCC2; ERCC3; GTF2H1; GTF2H2; GTF2H3; GTF2H4; H2AFV; H2AFZ; H3F3A; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; POLR1A; POLR1B; POLR1C; POLR1D; POLR1E; POLR2E; POLR2H; POLR2K; POLR2L; TAF1A; TAF1B; TAF1C; TAF1D; UBTF; ZNRD1"
"R-HSA-6811436","COPI-independent Golgi-to-ER retrograde traffic",-0.131456238375875,0.049707566426362,0.00817894408821649,17,"ACTR10; AGPAT3; BICD1; BICD2; CAPZA2; CAPZB; DCTN3; DCTN5; DCTN6; DYNC1H1; DYNC1LI2; DYNLL2; GALNT1; GALNT2; PAFAH1B1; RAB6A; RAB6B"
"R-HSA-983170","Antigen Presentation: Folding, assembly and peptide loading of class I MHC",0.237489939842725,0.0900956940751979,0.00838960697449385,14,"CALR; CANX; ERAP1; ERAP2; HLA-A; HLA-B; HLA-C; HLA-E; HSPA5; PDIA3; SAR1B; SEC13; SEC23A; SEC24C"
"R-HSA-445989","TAK1 activates NFkB by phosphorylation and activation of IKKs complex",0.126171328052358,0.0481010887236932,0.00871477198442989,15,"APP; IRAK2; MAP3K7; NFKB1; NFKBIA; NFKBIB; NKIRAS1; NOD1; RELA; S100B; TAB1; TAB2; TRAF6; UBE2N; UBE2V1"
"R-HSA-3299685","Detoxification of Reactive Oxygen Species",-0.183690823900346,0.0703787941388286,0.00905340577481334,16,"CAT; CYCS; GPX1; GPX3; GPX7; GSTP1; NOX4; NUDT2; P4HB; PRDX2; PRDX6; SOD1; SOD2; TXN; TXNRD1; TXNRD2"
"R-HSA-5696394","DNA Damage Recognition in GG-NER",-0.0970965678038994,0.0372389713259386,0.00912350476157229,19,"ACTB; ACTL6A; ACTR8; COPS2; COPS3; COPS6; COPS7A; CUL4A; INO80D; INO80E; NFRKB; PARP1; PARP2; RAD23A; RAD23B; RUVBL1; TFPT; UBA52; UBC"
"R-HSA-6782315","tRNA modification in the nucleus and cytosol",-0.19112223196553,0.0737800078993439,0.00958550342372028,27,"ADAT1; ADAT2; ALKBH8; CDKAL1; CTU1; CTU2; DUS2; LCMT2; NSUN2; NSUN6; OSGEP; PUS3; PUS7; THADA; THG1L; TPRKB; TRIT1; TRMT10A; TRMT11; TRMT112; TRMT44; TRMT5; TRMT61A; TYW1; TYW3; TYW5; URM1"
"R-HSA-418346","Platelet homeostasis",-0.0840475018766284,0.0325492633967291,0.00981832153823788,39,"APOB; ATP2A2; ATP2B1; ATP2B4; CALM1; FGR; GNB2; GNB3; GNB4; GNB5; GNG11; GNG4; GNG5; GNG7; GUCY1A2; ITPR2; ITPR3; KCNMA1; KCNMB4; LRP8; MAPK14; MRVI1; NOS1; NOS2; NOS3; ORAI2; P2RX4; P2RX5; P2RX6; P2RX7; PAFAH2; PDE10A; PDE1B; PDE2A; PDE3A; PDE3B; PDE5A; PDE9A; PPP2CA"
"R-HSA-422085","Synthesis, secretion, and deacylation of Ghrelin",-0.196315640257817,0.0762294267741161,0.0100145588223001,11,"ACHE; BCHE; CRHR2; IGF1; KLF4; PLA2G7; SEC11A; SEC11C; SPCS1; SPCS3; UCN"
"R-HSA-8953750","Transcriptional Regulation by E2F6",0.184271266427374,0.0720243357867405,0.0105137400574358,13,"CBX3; CDC7; CHEK1; E2F1; EHMT1; EZH2; L3MBTL2; MAX; MGA; PCGF6; RBBP4; RNF2; TFDP1"
"R-HSA-392154","Nitric oxide stimulates guanylate cyclase",-0.172119339748369,0.0675164175814687,0.0107940611560475,16,"GUCY1A2; KCNMA1; KCNMB4; MRVI1; NOS1; NOS2; NOS3; PDE10A; PDE1B; PDE2A; PDE3A; PDE3B; PDE5A; PDE9A; PRKG1; PRKG2"
"R-HSA-156580","Phase II - Conjugation of compounds",-0.152917469208695,0.0601546748184522,0.0110197708272123,37,"ABHD10; ABHD14B; ACSM5; AHCY; AS3MT; BPNT1; CHAC1; CHAC2; CNDP2; COMT; ESD; GCLC; GCLM; GGCT; GGT7; GLYATL2; GSS; GSTA4; GSTM1; GSTM2; GSTM3; GSTM4; GSTM5; GSTO1; GSTO2; GSTP1; GSTT1; GSTZ1; MAT2A; MGST1; MGST2; MGST3; MTR; MTRR; N6AMT1; PAPSS1; SLC26A1"
"R-HSA-4420097","VEGFA-VEGFR2 Pathway",0.0695758865386236,0.0273819631426609,0.0110555338886996,42,"ABI2; AHCYL1; AKT1; AKT2; AKT3; AXL; BCAR1; BRK1; CALM1; CAV1; CRK; CTNNA1; CYFIP1; CYFIP2; DOCK1; ELMO1; ELMO2; FYN; HSP90AA1; ITGAV; ITGB3; ITPR2; ITPR3; JUP; KDR; KRAS; MAPK11; MAPK12; MAPK13; MAPK14; MLST8; MTOR; NCK1; NOS3; PAK1; PAK2; PIK3CA; PIK3CB; PIK3R1; PLCG1; PRKACA; PRKCA"
"R-HSA-8866654","E3 ubiquitin ligases ubiquitinate target proteins",-0.0791058909059989,0.0311331744368788,0.0110571520196722,25,"DERL1; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; HLA-A; HLA-B; HLTF; LEO1; PEX10; PEX5; RAD18; RNF152; RNF181; RNF40; SHPRH; TMEM129; UBA52; UBC; UBE2E1; UBE2L3; UBE2N; WAC"
"R-HSA-9010553","Regulation of expression of SLITs and ROBOs",0.053759158934474,0.0212119271607181,0.0112645365200016,29,"CASC3; DAG1; ETF1; LDB1; LHX2; MAGOHB; NCBP1; NCBP2; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4"
"R-HSA-2142845","Hyaluronan metabolism",0.337485499364289,0.133169131996398,0.0112684375667542,10,"ABCC5; CD44; HAS1; HAS2; HEXA; HEXB; HMMR; HYAL1; HYAL3; LYVE1"
"R-HSA-109582","Hemostasis",0.0885335544038842,0.0350837032525982,0.0116194669013088,39,"A2M; ABCC4; ABHD12; ABHD6; ADRA2C; AK3; AKAP1; AKAP10; AKT1; AKT2; AKT3; ANGPT1; ANGPT2; ANXA2; ANXA5; APLP2; APOB; APP; ARRB1; ARRB2; ATP1B1; ATP1B2; ATP1B3; ATP2A2; ATP2B1; ATP2B4; BCAR1; BSG; C1QBP; CABLES1; CABLES2; CALM1; CALU; CAPZA2; CAPZB; CAV1; CD109; CD36; CD44"
"R-HSA-180786","Extension of Telomeres",-0.0911625243692688,0.0362405666755186,0.0118869456461372,18,"DNA2; FEN1; LIG1; POLA2; POLD2; POLD3; POLE; PRIM1; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3; RUVBL1; RUVBL2"
"R-HSA-422356","Regulation of insulin secretion",0.0883333361566604,0.0351626980323872,0.012000421912456,35,"ABCC8; ADCY6; ADRA2C; AHCYL1; AKAP5; CACNA1A; CACNA1C; CACNA1D; CACNA1E; CACNB3; GNA15; GNAI2; GNB2; GNB3; GNB4; GNB5; GNG11; GNG4; GNG5; GNG7; IQGAP1; ITPR2; ITPR3; KCNB1; KCNC2; KCNJ11; MARCKS; PLCB1; PLCB3; PRKACA; PRKAR1A; PRKAR1B; PRKAR2A; PRKCA; RAP1A"
"R-HSA-8852135","Protein ubiquitination",-0.0767648481713902,0.0307825949444299,0.012639283775231,34,"DERL1; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; HLA-A; HLA-B; HLTF; LEO1; PEX10; PEX5; RAD18; RNF152; RNF181; RNF40; SHPRH; TMEM129; UBA52; UBC; UBE2E1; UBE2E3; UBE2G1; UBE2G2; UBE2H; UBE2K; UBE2L3; UBE2N; UBE2Q2; UBE2R2; UBE2T; UBE2Z; UCHL3"
"R-HSA-8873719","RAB geranylgeranylation",-0.160024420494769,0.0643566120000643,0.0128996965835926,30,"CHML; PTP4A2; RAB11A; RAB14; RAB15; RAB1A; RAB21; RAB22A; RAB24; RAB26; RAB27A; RAB27B; RAB2A; RAB2B; RAB30; RAB31; RAB33B; RAB34; RAB36; RAB37; RAB3B; RAB3C; RAB3D; RAB40B; RAB5A; RAB5C; RAB6A; RAB6B; RAB8A; RABGGTA"
"R-HSA-1638091","Heparan sulfate/heparin (HS-GAG) metabolism",-0.148157747055828,0.059800024228566,0.0132286650711369,23,"B3GALT6; B3GAT1; B3GAT2; DCN; EXT1; EXT2; GLB1; GLCE; GPC5; HPSE; HPSE2; HS3ST1; HS3ST3B1; HS3ST5; HS6ST3; HSPG2; NAGLU; NCAN; NDST1; SDC2; SDC3; XYLT1; XYLT2"
"R-HSA-74259","Purine catabolism",-0.193479132872555,0.0783718999459773,0.0135593133949263,14,"ADPRM; DNPH1; GDA; GPX1; ITPA; NT5C; NT5C1A; NT5C2; NT5E; NUDT16; NUDT18; NUDT5; NUDT9; PNP"
"R-HSA-975634","Retinoid metabolism and transport",-0.134080279550138,0.0544663630168868,0.0138277207126775,19,"AKR1C1; AKR1C3; APOB; APOE; BCO2; GPC5; GPIHBP1; HSPG2; LRAT; LRP12; LRP2; LRP8; PLB1; RBP1; RBP4; RDH11; RETSAT; SDC2; SDC3"
"R-HSA-427359","SIRT1 negatively regulates rRNA expression",0.0917735779280208,0.0372828382774649,0.0138338037770931,17,"H2AFV; H2AFZ; H3F3A; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; RRP8; SIRT1; TAF1A; TAF1B; TAF1C; TAF1D"
"R-HSA-5673001","RAF/MAP kinase cascade",-0.0777038484937795,0.031610152932484,0.0139638208882439,24,"ANGPT1; ARRB1; ARRB2; BTC; CALM1; CAMK2B; CAMK2D; CUL3; DUSP16; DUSP4; DUSP6; DUSP7; EGF; EGFR; ERBB2; ERBB3; ERBB4; FGF1; FGF10; FGF17; FGF5; FGF9; FGFR1; FGFR2"
"R-HSA-5684996","MAPK1/MAPK3 signaling",-0.0777038484937795,0.031610152932484,0.0139638208882439,24,"ANGPT1; ARRB1; ARRB2; BTC; CALM1; CAMK2B; CAMK2D; CUL3; DUSP16; DUSP4; DUSP6; DUSP7; EGF; EGFR; ERBB2; ERBB3; ERBB4; FGF1; FGF10; FGF17; FGF5; FGF9; FGFR1; FGFR2"
"R-HSA-5576892","Phase 0 - rapid depolarisation",-0.126153588994123,0.0513416591273712,0.0140048517290917,18,"CACNA1C; CACNA1D; CACNA2D1; CACNA2D3; CACNB3; CACNG2; CACNG4; CALM1; CAMK2B; CAMK2D; SCN11A; SCN1A; SCN1B; SCN4B; SCN5A; SCN7A; SCN8A; SCN9A"
"R-HSA-72165","mRNA Splicing - Minor Pathway",-0.0800516303664408,0.0326049312102137,0.0140806186121193,28,"DDX23; GTF2F2; NCBP1; NCBP2; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L; PRPF6; RNPC3; SF3B1; SF3B2; SF3B3; SF3B5; SNRNP200; SNRNP25; SNRNP35; SNRNP40; SNRNP48; SNRPF; SRSF7; TXNL4A; YBX1; ZCRB1"
"R-HSA-375170","CDO in myogenesis",0.146071322851797,0.0601241039927408,0.0151197951984838,17,"BNIP2; BOC; CDH4; CDON; CTNNA1; CTNNA2; MAP2K6; MAPK11; MAPK12; MAPK14; MEF2A; MEF2C; MEF2D; NEO1; SPAG9; TCF12; TCF3"
"R-HSA-525793","Myogenesis",0.146071322851797,0.0601241039927408,0.0151197951984838,17,"BNIP2; BOC; CDH4; CDON; CTNNA1; CTNNA2; MAP2K6; MAPK11; MAPK12; MAPK14; MEF2A; MEF2C; MEF2D; NEO1; SPAG9; TCF12; TCF3"
"R-HSA-109704","PI3K Cascade",0.0826709297031605,0.0341656105447537,0.0155328137874466,20,"AKT2; FGF1; FGF10; FGF17; FGF5; FGF9; FGFR1; FGFR2; GAB1; GRB2; KL; KLB; PDE3B; PIK3C3; PIK3CA; PIK3CB; PIK3R1; PTPN11; THEM4; TRIB3"
"R-HSA-1442490","Collagen degradation",0.171592750132439,0.0713358450542085,0.0161538377372922,17,"ADAM10; ADAM17; ADAM9; COL12A1; COL14A1; COL15A1; COL16A1; COL18A1; COL19A1; COL23A1; COL26A1; CTSB; CTSD; CTSK; FURIN; MMP2; PHYKPL"
"R-HSA-373753","Nephrin family interactions",-0.117282316502314,0.0492148675323437,0.0171690788858823,10,"CD2AP; FYN; IQGAP1; KIRREL3; MAGI2; NCK1; PIK3CA; PIK3CB; PIK3R1; SPTBN1"
"R-HSA-195258","RHO GTPase Effectors",-0.0845545603993014,0.0355062146233103,0.0172468924639031,34,"ABI2; ACTB; ACTG1; ACTR2; ARPC1A; ARPC1B; ARPC2; ARPC3; ARPC4; BRK1; BUB3; CALM1; CDH1; CDKN1B; CENPC; CENPE; CENPH; CENPL; CENPN; CENPP; CENPQ; CENPT; CFL1; CFTR; CIT; CKAP5; CLIP1; CTNNA1; CYFIP1; CYFIP2; DAAM1; DIAPH1; DSN1; DVL1"
"R-HSA-1236975","Antigen processing-Cross presentation",-0.0526669888522261,0.0221273466631468,0.0173043510460811,28,"CALR; CD14; CD36; CTSS; HLA-A; HLA-B; HLA-C; HLA-E; ITGAV; ITGB5; MRC2; PDIA3; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4"
"R-HSA-6806667","Metabolism of fat-soluble vitamins",-0.130049116922035,0.0548476239090275,0.0177353055361087,21,"AKR1C1; AKR1C3; APOB; APOE; BCO2; GPC5; GPIHBP1; HSPG2; LRAT; LRP12; LRP2; LRP8; PLB1; RBP1; RBP4; RDH11; RETSAT; SDC2; SDC3; TTPA; UBIAD1"
"R-HSA-4419969","Depolymerisation of the Nuclear Lamina",-0.155963681190444,0.0658332772396132,0.0178328493448787,10,"CNEP1R1; LEMD2; LEMD3; LMNB1; LPIN1; LPIN2; LPIN3; PRKCA; PRKCB; TMPO"
"R-HSA-6790901","rRNA modification in the nucleus and cytosol",-0.137501710046519,0.0581412127337481,0.0180319617924288,39,"BMS1; DCAF13; DDX47; DDX52; DHX37; DIMT1; FBL; GAR1; HEATR1; IMP4; KRR1; MPHOSPH10; NAT10; NOL11; NOL6; NOP10; NOP14; NOP2; NOP56; NOP58; PDCD11; PNO1; PWP2; RCL1; RPS14; RPS2; RPS7; RPS9; RRP36; RRP7A; TBL3; THUMPD1; TRMT112; TSR3; UTP18; UTP20; UTP6; WDR36; WDR75"
"R-HSA-159227","Transport of the SLBP independent Mature mRNA",-0.0654691478302508,0.0278147623071913,0.0185848343100826,23,"AAAS; EIF4E; NCBP1; NCBP2; NDC1; NUP107; NUP205; NUP214; NUP35; NUP37; NUP43; NUP50; NUP54; NUP62; NUP85; NUP88; NUP93; NXF1; POM121; POM121C; RAE1; RANBP2; SEH1L"
"R-HSA-159230","Transport of the SLBP Dependant Mature mRNA",-0.0654691478302508,0.0278147623071913,0.0185848343100826,23,"AAAS; EIF4E; NCBP1; NCBP2; NDC1; NUP107; NUP205; NUP214; NUP35; NUP37; NUP43; NUP50; NUP54; NUP62; NUP85; NUP88; NUP93; NXF1; POM121; POM121C; RAE1; RANBP2; SEH1L"
"R-HSA-196807","Nicotinate metabolism",-0.198434765906499,0.0844506072162907,0.018787845627323,17,"CD38; NADK2; NADSYN1; NAMPT; NMNAT1; NMNAT2; NMNAT3; NMRK1; NT5E; NUDT12; PARP10; PARP14; PARP4; PARP6; PARP8; PARP9; QPRT"
"R-HSA-264876","Insulin processing",0.24956110918035,0.106260296299521,0.0188450063611037,16,"EXOC1; EXOC2; EXOC3; EXOC4; EXOC6; EXOC7; KIF5A; KIF5C; MYO5A; MYRIP; PCSK2; RAB27A; SLC30A5; SLC30A6; SLC30A7; VAMP2"
"R-HSA-5083635","Defective B3GALTL causes Peters-plus syndrome (PpS)",0.163099891298564,0.0695586725070569,0.0190382308476167,22,"ADAMTS1; ADAMTS13; ADAMTS14; ADAMTS17; ADAMTS18; ADAMTS19; ADAMTS2; ADAMTS3; ADAMTS5; ADAMTS6; ADAMTS8; ADAMTS9; ADAMTSL1; ADAMTSL2; ADAMTSL3; SEMA5B; SPON1; SPON2; SSPO; THBS2; THSD1; THSD7A"
"R-HSA-5173214","O-glycosylation of TSR domain-containing proteins",0.163099891298564,0.0695586725070569,0.0190382308476167,22,"ADAMTS1; ADAMTS13; ADAMTS14; ADAMTS17; ADAMTS18; ADAMTS19; ADAMTS2; ADAMTS3; ADAMTS5; ADAMTS6; ADAMTS8; ADAMTS9; ADAMTSL1; ADAMTSL2; ADAMTSL3; SEMA5B; SPON1; SPON2; SSPO; THBS2; THSD1; THSD7A"
"R-HSA-5620922","BBSome-mediated cargo-targeting to cilium",0.213785689755618,0.0916998535793311,0.0197342015212364,18,"BBS1; BBS10; BBS12; BBS2; BBS4; BBS5; BBS7; BBS9; CCT3; CCT4; CCT5; CCT8; MCHR1; MKKS; RAB3IP; SMO; SSTR3; TTC8"
"R-HSA-201451","Signaling by BMP",-0.178693449426884,0.076736173215558,0.0198763991655044,14,"ACVR2B; ACVRL1; BMP2; BMPR1A; BMPR1B; FSTL1; GREM2; NOG; SMAD1; SMAD5; SMAD7; SMAD9; SMURF1; ZFYVE16"
"R-HSA-162582","Signal Transduction",0.101808983478266,0.0441592495811168,0.0211387975899629,30,"A2M; AATF; ABCA4; ABHD12; ABHD6; ABI2; ABR; ACKR3; ACKR4; ACTB; ACTG1; ACTR2; ACVR2B; ACVRL1; ADAM10; ADAM17; ADCY10; ADCY3; ADCY6; ADCY7; ADCYAP1; ADCYAP1R1; ADM; ADORA2B; ADRA1A; ADRA1B; ADRA2C; ADRB2; AGO2; AGT"
"R-HSA-168638","NOD1/2 Signaling Pathway",-0.0949748195510713,0.0412063755107854,0.0211745610861843,19,"BIRC2; CASP4; CASP8; CASP9; CYLD; IRAK2; MAP2K6; MAP3K7; MAPK11; MAPK12; MAPK13; MAPK14; NOD1; TAB1; TAB2; TNFAIP3; TRAF6; UBE2N; UBE2V1"
"R-HSA-5610787","Hedgehog 'off' state",-0.0535839171216611,0.0232886164150015,0.0213993729386663,33,"ADCY10; ADCY3; ADCY6; ADCY7; BTRC; DYNC2H1; FUZ; GPR161; GSK3B; IFT122; IFT52; IFT57; IFT88; INTU; KIF7; MKS1; NUMB; PRKACA; PRKAR1A; PRKAR1B; PRKAR2A; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5"
"R-HSA-75876","Synthesis of very long-chain fatty acyl-CoAs",0.338992122760515,0.147875758390114,0.0218818959271611,11,"ACSF3; ACSL1; ACSL5; ACSL6; ELOVL1; ELOVL2; ELOVL4; ELOVL5; ELOVL7; HSD17B12; TECR"
"R-HSA-8956319","Nucleobase catabolism",-0.177744042495606,0.0778609301000281,0.0224397972224369,20,"ADPRM; DNPH1; ENTPD1; ENTPD5; ENTPD6; GDA; GPX1; ITPA; NT5C; NT5C1A; NT5C2; NT5C3A; NT5E; NT5M; NUDT16; NUDT18; NUDT5; NUDT9; PNP; TYMP"
"R-HSA-381042","PERK regulates gene expression",-0.128813709607632,0.0565829180182245,0.0228132514575547,19,"ASNS; ATF3; ATF4; ATF6; CCL2; DCP2; EIF2AK3; EIF2S1; EXOSC2; EXOSC3; EXOSC4; EXOSC5; EXOSC6; EXOSC8; EXOSC9; HSPA5; NFYB; NFYC; PARN"
"R-HSA-5389840","Mitochondrial translation elongation",-0.130659134169555,0.0575206315511756,0.0231156551533874,35,"GFM1; MRPL1; MRPL10; MRPL13; MRPL14; MRPL17; MRPL18; MRPL2; MRPL21; MRPL22; MRPL23; MRPL24; MRPL28; MRPL34; MRPL35; MRPL38; MRPL39; MRPL4; MRPL40; MRPL42; MRPL43; MRPL44; MRPL45; MRPL48; MRPL50; MRPL51; MRPL52; MRPL54; MRPL55; MRPS10; MRPS12; MRPS16; MRPS18C; MRPS21; MRPS22"
"R-HSA-193648","NRAGE signals death through JNK",-0.1048906237631,0.046338005121704,0.0235988402903933,33,"AATF; ABR; AKAP13; ARHGEF1; ARHGEF10; ARHGEF10L; ARHGEF11; ARHGEF12; ARHGEF18; ARHGEF3; ARHGEF33; ARHGEF4; ARHGEF40; BCL2L11; ECT2; FGD2; FGD3; FGD4; GNA13; ITSN1; KALRN; MAPK8; MCF2L; OBSCN; PLEKHG2; PLEKHG5; PREX1; RASGRF2; SOS2; TIAM2; TRIO; VAV2; VAV3"
"R-HSA-69017","CDK-mediated phosphorylation and removal of Cdc6",-0.0433481120483648,0.0191653558490434,0.0237100525202254,25,"CDK2; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; UBA52; UBC"
"R-HSA-168325","Viral Messenger RNA Synthesis",-0.0536251135178352,0.0238184820391127,0.0243597278130164,28,"AAAS; GTF2F2; NDC1; NUP107; NUP205; NUP214; NUP35; NUP37; NUP43; NUP50; NUP54; NUP62; NUP85; NUP88; NUP93; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L; POM121; POM121C; RAE1; RANBP2; SEH1L"
"R-HSA-156590","Glutathione conjugation",-0.166915191779856,0.0742753499529805,0.024624130381116,23,"CHAC1; CHAC2; CNDP2; ESD; GCLC; GCLM; GGCT; GGT7; GSS; GSTA4; GSTM1; GSTM2; GSTM3; GSTM4; GSTM5; GSTO1; GSTO2; GSTP1; GSTT1; GSTZ1; MGST1; MGST2; MGST3"
"R-HSA-8854050","FBXL7 down-regulates AURKA during mitotic entry and in early mitosis",-0.0431705011157821,0.0192730966884268,0.0250950847815344,25,"PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; SKP1; UBA52; UBC"
"R-HSA-5688426","Deubiquitination",0.0699584489300367,0.0312482301710946,0.0251691172261792,32,"ACTB; ACTL6A; ACTR8; ADRB2; ARRB1; ARRB2; ASXL1; ASXL2; ATXN3; AXIN1; BAP1; BARD1; BIRC2; CCNA1; CCNA2; CDC25A; CFTR; CYLD; DDX58; ESR1; FKBP8; FOXK1; FOXK2; HIF1A; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN"
"R-HSA-5368287","Mitochondrial translation",-0.128491547556952,0.0579270196006294,0.0265437487872056,35,"GFM1; GFM2; MRPL1; MRPL10; MRPL13; MRPL14; MRPL17; MRPL18; MRPL2; MRPL21; MRPL22; MRPL23; MRPL24; MRPL28; MRPL34; MRPL35; MRPL38; MRPL39; MRPL4; MRPL40; MRPL42; MRPL43; MRPL44; MRPL45; MRPL48; MRPL50; MRPL51; MRPL52; MRPL54; MRPL55; MRPS10; MRPS12; MRPS16; MRPS18C; MRPS21"
"R-HSA-350562","Regulation of ornithine decarboxylase (ODC)",0.0476411748487386,0.0214842622538048,0.0265895044611281,26,"AZIN1; OAZ1; OAZ2; ODC1; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1"
"R-HSA-5663202","Diseases of signal transduction",0.0709768016546621,0.0321263250690902,0.0271535395687987,33,"ADAM10; ADAM17; AGGF1; AGTRAP; AKT1; AKT2; AKT3; AP3B1; ARRB1; ARRB2; ATG7; AXIN1; BAG4; BCL2L11; BCR; BTC; CASP9; CBL; CDC37; CDK8; CDKN1A; CDKN1B; CLCN6; CNTRL; CREB1; CTBP2; DKK1; DLL4; EGF; EGFR; ERBB2; ERBB3; ERBB4"
"R-HSA-5619084","ABC transporter disorders",-0.0421332812168634,0.0191546660169479,0.0278327743265638,32,"ABCC8; CFTR; DERL1; ERLEC1; ERLIN2; KCNJ11; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; RNF185; SFTPD; UBA52; UBC"
"R-HSA-1489509","DAG and IP3 signaling",-0.0819653375055485,0.0372738876535223,0.0278778105992877,18,"ADCY3; ADCY6; ADCY7; AHCYL1; CALM1; CAMK4; CREB1; ITPR2; ITPR3; PDE1B; PDE1C; PLCG1; PRKACA; PRKAR1A; PRKAR1B; PRKAR2A; PRKCA; PRKCD"
"R-HSA-1236978","Cross-presentation of soluble exogenous antigens (endosomes)",0.0469525589219268,0.021519537386647,0.0291200688889913,23,"MRC2; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1"
"R-HSA-351202","Metabolism of polyamines",-0.0464783989487742,0.0214269163596629,0.0300705775313799,38,"ADI1; AGMAT; AMD1; APIP; ARG2; ASL; ASS1; AZIN1; CKMT2; CPS1; ENOPH1; MRI1; MTAP; NAGS; NMRAL1; OAZ1; OAZ2; ODC1; PAOX; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7"
"R-HSA-1643685","Disease",-0.0623797600016363,0.0289179088502542,0.0309953446894882,41,"AAAS; ABCC8; ACACA; ACAN; ADAM10; ADAM17; ADAMTS1; ADAMTS13; ADAMTS14; ADAMTS17; ADAMTS18; ADAMTS19; ADAMTS2; ADAMTS3; ADAMTS5; ADAMTS6; ADAMTS8; ADAMTS9; ADAMTSL1; ADAMTSL2; ADAMTSL3; AGGF1; AGTRAP; AKT1; AKT2; AKT3; ANTXR1; ANTXR2; AP1B1; AP1M1; AP1S1; AP2A2; AP2B1; AP2M1; AP3B1; APOBEC3G; APP; ARF1; ARRB1; ARRB2; ATG7"
"R-HSA-1236394","Signaling by ERBB4",-0.0627634106980066,0.0292941023844796,0.0321510835643374,23,"ADAM17; BTC; EGF; EGFR; ERBB3; ERBB4; ESR1; GRB2; KRAS; NCOR1; NEDD4; NRG2; NRG4; PIK3CA; PIK3R1; PSEN1; PSEN2; S100B; TAB2; UBA52; UBC; WWOX; WWP1"
"R-HSA-5250924","B-WICH complex positively regulates rRNA expression",0.0602558892957446,0.0281679826045025,0.0324225181036498,33,"ACTB; CD3EAP; DEK; ERCC6; GSK3B; H2AFV; H2AFZ; H3F3A; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; KAT2B; MYBBP1A; POLR1A; POLR1B; POLR1C; POLR1D; POLR1E; POLR2E; POLR2H; POLR2K; POLR2L; SF3B1; TAF1A; TAF1B; TAF1C; TAF1D; ZNRD1"
"R-HSA-5358346","Hedgehog ligand biogenesis",-0.040720983547065,0.0191301711304803,0.0332851987797988,32,"ADAM17; DISP2; ERLEC1; GPC5; HHAT; P4HB; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; SCUBE2; SYVN1; UBA52; UBC"
"R-HSA-1474165","Reproduction",-0.0644469681979901,0.0303731962481838,0.0338514378041598,27,"ACD; ADAM21; ATM; BLM; BRCA2; CATSPER2; CD9; CDK2; DIDO1; DMC1; H2AFV; H2AFZ; H3F3A; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; HSPA2; HVCN1; IZUMO4; LMNB1; MLH1; MLH3"
"R-HSA-449836","Other interleukin signaling",-0.149084655069571,0.070490322660207,0.0344328218786456,12,"CASP3; CD4; CSF1; FLT3; IFNLR1; IL10RB; IL16; JAK1; STX3; STX4; TYK2; VAMP2"
"R-HSA-5368286","Mitochondrial translation initiation",-0.12500604682808,0.0591662131479734,0.0346183648306115,34,"MRPL1; MRPL10; MRPL13; MRPL14; MRPL17; MRPL18; MRPL2; MRPL21; MRPL22; MRPL23; MRPL24; MRPL28; MRPL34; MRPL35; MRPL38; MRPL39; MRPL4; MRPL40; MRPL42; MRPL43; MRPL44; MRPL45; MRPL48; MRPL50; MRPL51; MRPL52; MRPL54; MRPL55; MRPS10; MRPS12; MRPS16; MRPS18C; MRPS21; MRPS22"
"R-HSA-4086398","Ca2+ pathway",0.0787998118942735,0.0373490807868067,0.0348739224547871,27,"AGO2; CALM1; FZD3; FZD6; GNAO1; GNB2; GNB3; GNB4; GNB5; GNG11; GNG4; GNG5; GNG7; ITPR2; ITPR3; MAP3K7; MYC; NFATC1; NLK; PLCB1; PLCB3; PPP3CB; PPP3R1; PRKCA; PRKG1; PRKG2; WNT5A"
"R-HSA-1234176","Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha",-0.0405834388982132,0.019240682789092,0.0349228793405263,31,"AJUBA; EGLN1; EGLN2; HIF1A; HIF3A; LIMD1; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; UBA52; UBC; VHL"
"R-HSA-375280","Amine ligand-binding receptors",0.232408279666235,0.110565287951668,0.0355532406335265,15,"ADRA1A; ADRA1B; ADRA2C; ADRB2; CHRM1; CHRM4; CHRM5; DRD5; HRH1; HRH2; HTR1A; HTR1E; HTR1F; HTR2A; HTR4"
"R-HSA-8956320","Nucleobase biosynthesis",-0.213152690377737,0.101658940761726,0.0360163161793434,10,"ADSSL1; ATIC; DHODH; GART; IMPDH1; LHPP; PAICS; PFAS; PPAT; UMPS"
"R-HSA-191273","Cholesterol biosynthesis",0.247335324910294,0.118137234715352,0.0362932048881102,17,"ARV1; CYP51A1; DHCR24; DHCR7; FDPS; GGPS1; HMGCS1; HSD17B7; IDI1; LBR; LSS; MSMO1; MVD; MVK; PMVK; SQLE; TM7SF2"
"R-HSA-5419276","Mitochondrial translation termination",-0.122630302164083,0.059011196137628,0.0377014987630254,35,"GFM2; MRPL1; MRPL10; MRPL13; MRPL14; MRPL17; MRPL18; MRPL2; MRPL21; MRPL22; MRPL23; MRPL24; MRPL28; MRPL34; MRPL35; MRPL38; MRPL39; MRPL4; MRPL40; MRPL42; MRPL43; MRPL44; MRPL45; MRPL48; MRPL50; MRPL51; MRPL52; MRPL54; MRPL55; MRPS10; MRPS12; MRPS16; MRPS18C; MRPS21; MRPS22"
"R-HSA-3000178","ECM proteoglycans",0.138519222409985,0.0670931492458535,0.0389626890073114,25,"ACAN; ASPN; DAG1; DCN; FMOD; HSPG2; ITGA2; ITGA8; ITGA9; ITGAV; ITGAX; ITGB3; ITGB5; LAMA1; LAMA2; LAMA5; LAMC1; LRP4; LUM; NCAN; SPARC; TGFB1; TGFB2; TGFB3; TNC"
"R-HSA-399956","CRMPs in Sema3A signaling",-0.131882033511826,0.0640095983802356,0.0393653058652462,12,"CDK5; CDK5R1; DPYSL4; DPYSL5; FES; FYN; GSK3B; NRP1; PLXNA1; PLXNA2; PLXNA4; SEMA3A"
"R-HSA-1474228","Degradation of the extracellular matrix",0.0979849188777486,0.0478629568453972,0.040638710586107,41,"A2M; ACAN; ADAM10; ADAM15; ADAM17; ADAM8; ADAM9; ADAMTS1; ADAMTS18; ADAMTS5; ADAMTS8; ADAMTS9; BMP1; BSG; CAPN1; CAPN10; CAPN14; CAPN15; CAPN2; CAPN3; CAPN5; CAPN7; CASP3; CAST; CD44; CDH1; COL12A1; COL14A1; COL15A1; COL16A1; COL18A1; COL19A1; COL23A1; COL26A1; CTSB; CTSD; CTSK; CTSS; DCN; FURIN; HSPG2"
"R-HSA-8941858","Regulation of RUNX3 expression and activity",-0.0393822361207452,0.0192704514927942,0.0409872232138594,27,"MDM2; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSMF1; SMURF1; SRC; TGFB1; UBA52; UBC"
"R-HSA-5621481","C-type lectin receptors (CLRs)",0.080164891160134,0.039239855145027,0.0410578191776248,22,"AHCYL1; BTRC; CALM1; CARD11; CASP8; CLEC4A; CLEC7A; FYN; ICAM3; ITPR2; ITPR3; KRAS; LYN; MALT1; MAP3K7; MUC12; MUC20; NFATC1; NFKB1; NFKBIA; PAK1; PAK2"
"R-HSA-1834949","Cytosolic sensors of pathogen-associated DNA ",-0.0589060411390401,0.0288922690681677,0.0414683233596235,30,"APP; CRCP; DDX41; IFI16; LRRFIP1; NFKB1; NFKBIA; NFKBIB; NKIRAS1; NLRC3; POLR1C; POLR1D; POLR2E; POLR2H; POLR2K; POLR2L; POLR3E; POLR3G; POLR3H; POLR3K; RELA; S100B; STAT6; TBK1; TICAM1; TMEM173; TRIM21; UBA52; UBC; XRCC6"
"R-HSA-6807004","Negative regulation of MET activity",-0.0769646612527776,0.0380436471556131,0.0430667439290598,12,"CBL; EPS15; GRB2; LRIG1; MET; PTPN2; PTPRJ; SH3GL2; STAM; STAM2; UBA52; UBC"
"R-HSA-1428517","The citric acid (TCA) cycle and respiratory electron transport",0.148924059152844,0.0740238462600522,0.0442369137305171,33,"ACAD9; ADHFE1; BSG; COQ10A; COQ10B; COX11; COX14; COX16; COX18; COX20; COX4I1; COX5A; COX6A1; COX6B1; COX6C; COX7A2L; CYCS; D2HGDH; DLAT; DLD; DLST; ETFB; ETFDH; GLO1; HAGH; IDH2; IDH3A; IDH3B; LDHB; LRPPRC; MDH2; MPC1; MPC2"
"R-HSA-202403","TCR signaling",0.0504720222412279,0.0252683605573836,0.0457774572092587,28,"BTRC; CARD11; CD4; ENAH; INPP5D; LCP2; MALT1; MAP3K7; NCK1; NFKB1; NFKBIA; PAG1; PAK1; PAK2; PIK3CA; PIK3CB; PIK3R1; PLCG1; PRKCQ; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6"
"R-HSA-1266738","Developmental Biology",-0.0646925068213361,0.0325108642303701,0.0466048734801995,41,"ABL2; ABLIM1; ABLIM2; ABLIM3; ACTB; ACTG1; ACTR2; ACVR2B; ADAM10; ADAM22; ADAM23; AJUBA; AKAP5; AKT1; AKT2; AKT3; ALCAM; ANGPTL4; ANK1; AP2A2; AP2B1; AP2M1; ARHGAP39; ARHGEF11; ARHGEF12; ARHGEF28; ARPC1A; ARPC1B; ARPC2; ARPC3; ARPC4; ASH2L; BNIP2; BOC; CACNA1C; CACNA1D; CACNA1G; CACNA1I; CACNB3; CACNG2; CACNG4"
"R-HSA-9012852","Signaling by NOTCH3",-0.0678894322838627,0.0341939604919092,0.0470975700286499,23,"ADAM10; DLL4; EGF; EGFR; HES1; HEY2; JAG1; KAT2B; MAML1; MIB1; NOTCH1; NOTCH3; PBX1; PLXND1; PSEN1; PSEN2; RBPJ; SNW1; TACC3; UBA52; UBC; WWP2; YBX1"
"R-HSA-187577","SCF(Skp2)-mediated degradation of p27/p21",-0.0367989657586193,0.0186458884406767,0.0484306595349279,31,"CCNA1; CCNA2; CDK2; CDKN1A; CDKN1B; CKS1B; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSMF1; SKP1; SKP2; UBA52; UBC"
"R-HSA-2980736","Peptide hormone metabolism",-0.115048831856065,0.0584435890903061,0.0490053700950628,26,"ACE; ACHE; AGT; BCHE; CRHR2; CTSD; CTSZ; DPP4; ENPEP; EXOC1; EXOC2; EXOC3; EXOC4; EXOC6; EXOC7; FFAR4; GNB3; IGF1; INHBA; KIF5A; KIF5C; KLF4; MYO5A; MYRIP; PAX6; PCSK2"
"R-HSA-8878171","Transcriptional regulation by RUNX1",-0.0628230463637152,0.031970529698611,0.0494107784975951,28,"ACTL6A; ACTL6B; AGO2; ARID1A; ASH2L; AXIN1; CBX4; CCND2; CCND3; CDK6; CDK7; CR1; CSNK2A2; CTSK; DPY30; ELF1; ELF2; ESR1; GPAM; H2AFV; H2AFZ; H3F3A; HDAC1; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD"
"R-HSA-397014","Muscle contraction",-0.0870068173901839,0.0443767642431051,0.0499211423673097,29,"ABCC9; ACTA2; AHCYL1; ANXA1; ANXA2; ANXA6; ASPH; ATP1A1; ATP1A3; ATP1B1; ATP1B2; ATP1B3; ATP2A2; ATP2B1; ATP2B4; CACNA1C; CACNA1D; CACNA2D1; CACNA2D3; CACNB3; CACNG2; CACNG4; CALM1; CAMK2B; CAMK2D; CORIN; DMPK; FKBP1B; FXYD6"
"R-HSA-73772","RNA Polymerase I Promoter Escape",0.066744347653195,0.0341785537497192,0.0508416758087271,24,"CD3EAP; CDK7; ERCC2; ERCC3; GTF2H1; GTF2H2; GTF2H3; GTF2H4; POLR1A; POLR1B; POLR1C; POLR1D; POLR1E; POLR2E; POLR2H; POLR2K; POLR2L; RRN3; TAF1A; TAF1B; TAF1C; TAF1D; UBTF; ZNRD1"
"R-HSA-157858","Gap junction trafficking and regulation",0.134053184982125,0.0688925504410222,0.0516751749264908,14,"AP2M1; CLTA; CLTCL1; DAB2; DNM2; GJA1; GJB2; GJB6; GJC1; GJC2; GJD2; MYO6; SRC; TJP1"
"R-HSA-69615","G1/S DNA Damage Checkpoints",-0.0351146901692342,0.0180684391470361,0.0519646031153473,36,"ATM; CCNA1; CCNA2; CDC25A; CDK2; CDKN1A; CDKN1B; CHEK1; MDM2; MDM4; PCBP4; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; TP53; UBA52; UBC"
"R-HSA-4641257","Degradation of AXIN",-0.0374103760914434,0.0193503227194125,0.0531967248100186,28,"AXIN1; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; RNF146; TNKS; TNKS2; UBA52; UBC"
"R-HSA-193704","p75 NTR receptor-mediated signalling",-0.0723799575548948,0.0374630914038227,0.0533553384224475,37,"AATF; ABR; ADAM17; AKAP13; ARHGEF1; ARHGEF10; ARHGEF10L; ARHGEF11; ARHGEF12; ARHGEF18; ARHGEF3; ARHGEF33; ARHGEF4; ARHGEF40; BCL2L11; CASP3; ECT2; FGD2; FGD3; FGD4; GNA13; HDAC1; HDAC2; HDAC3; ITGB3BP; ITSN1; KALRN; LINGO1; MAG; MAPK8; MCF2L; NFKB1; NFKBIA; OBSCN; OMG; PLEKHG2; PLEKHG5"
"R-HSA-202040","G-protein activation",0.0962466870940264,0.0499966478789658,0.0542215017954664,12,"GNAI2; GNAO1; GNAZ; GNB2; GNB3; GNB4; GNB5; GNG11; GNG4; GNG5; GNG7; POMC"
"R-HSA-69563","p53-Dependent G1 DNA Damage Response",-0.0350447198622673,0.0182234851902065,0.0544734492302155,34,"ATM; CCNA1; CCNA2; CDK2; CDKN1A; CDKN1B; MDM2; MDM4; PCBP4; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; TP53; UBA52; UBC"
"R-HSA-69580","p53-Dependent G1/S DNA damage checkpoint",-0.0350447198622673,0.0182234851902065,0.0544734492302155,34,"ATM; CCNA1; CCNA2; CDK2; CDKN1A; CDKN1B; MDM2; MDM4; PCBP4; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; TP53; UBA52; UBC"
"R-HSA-68877","Mitotic Prometaphase",-0.0711426990941737,0.0370730868781495,0.0549862271895067,30,"ALMS1; BUB3; CDK5RAP2; CENPC; CENPE; CENPH; CENPJ; CENPL; CENPN; CENPP; CENPQ; CENPT; CEP135; CEP164; CEP192; CEP250; CEP290; CEP41; CEP57; CEP63; CEP72; CEP76; CKAP5; CLIP1; CNTRL; CSNK1D; CSNK2A2; DCTN3; DSN1; DYNC1H1"
"R-HSA-4608870","Asymmetric localization of PCP proteins",-0.036871540917526,0.019241196971278,0.0553293330520724,33,"DVL2; FZD1; FZD3; FZD8; PARD6A; PRICKLE1; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; SMURF1; UBA52; UBC; VANGL2; WNT5A"
"R-HSA-163560","Triglyceride catabolism",-0.137736325888331,0.0721437758184212,0.0562373167676216,10,"ABHD5; CAV1; FABP3; GPD2; MGLL; PLIN1; PLIN3; PNPLA5; PPP1CB; PRKACA"
"R-HSA-5625886","Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3",0.0726119489179698,0.0380808714568637,0.0565487256243564,12,"H2AFV; H2AFZ; H3F3A; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; KDM4C"
"R-HSA-8943724","Regulation of PTEN gene transcription",0.0747250174557027,0.0393983273237106,0.057873543674928,29,"ATN1; CBX4; EGR1; EZH2; GATAD2A; HDAC1; HDAC2; HDAC3; HDAC5; JUN; LAMTOR3; LAMTOR4; LAMTOR5; MAPK1; MAPK3; MBD3; MLST8; MTA3; MTOR; NR2E1; PHC2; PTEN; RBBP4; RCOR1; REST; RNF2; RPTOR; SLC38A9; TP53"
"R-HSA-174154","APC/C:Cdc20 mediated degradation of Securin",-0.0356292268070332,0.019046995922165,0.0614011546409627,29,"ANAPC16; ANAPC4; ANAPC5; CDC16; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; UBA52; UBC; UBE2E1"
"R-HSA-196849","Metabolism of water-soluble vitamins and cofactors",-0.109851411053217,0.0587484035040472,0.0615029749876757,41,"ABCC1; ABCD4; ACACA; ACACB; ALDH1L2; AOX1; CD320; CD38; COASY; CUBN; CYB5A; CYB5R3; DHFR; ENPP1; ENPP2; FASN; GPHN; GSTO1; GSTO2; HLCS; LMBRD1; MCCC1; MCCC2; MMAA; MMAB; MOCS1; MOCS3; MTHFD1; MTHFD1L; MTHFR; MTHFS; MTR; MTRR; NADK2; NADSYN1; NAMPT; NFS1; NMNAT1; NMNAT2; NMNAT3; NMRK1"
"R-HSA-2559582","Senescence-Associated Secretory Phenotype (SASP)",0.0500317828443995,0.0267770278816869,0.0616980985126294,30,"ANAPC16; ANAPC4; ANAPC5; CCNA1; CCNA2; CDC16; CDK2; CDK6; CDKN1A; CDKN1B; CDKN2B; CDKN2C; CEBPB; EHMT1; H2AFV; H2AFZ; H3F3A; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; IGFBP7; JUN; MAPK1; MAPK3; NFKB1"
"R-HSA-376172","DSCAM interactions",-0.106300005850178,0.0568958587200953,0.0617166601029776,10,"DCC; DSCAM; DSCAML1; MAPK11; MAPK12; MAPK13; MAPK14; MAPK8; NTN1; PAK1"
"R-HSA-77289","Mitochondrial Fatty Acid Beta-Oxidation",0.177163724887803,0.0960884608698921,0.0652186339474845,22,"ACAA2; ACADL; ACADM; ACADS; ACADVL; ACBD6; ACBD7; ACOT1; ACOT11; ACOT2; ACSF2; DECR1; ECHS1; HADH; HADHA; HADHB; MCAT; MMAA; NDUFAB1; PCCB; PCTP; THEM4"
"R-HSA-69601","Ubiquitin Mediated Degradation of Phosphorylated Cdc25A",-0.0351703746060195,0.0190834143937169,0.0653317504743825,27,"ATM; CDC25A; CHEK1; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; UBA52; UBC"
"R-HSA-69610","p53-Independent DNA Damage Response",-0.0351703746060195,0.0190834143937169,0.0653317504743825,27,"ATM; CDC25A; CHEK1; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; UBA52; UBC"
"R-HSA-69613","p53-Independent G1/S DNA damage checkpoint",-0.0351703746060195,0.0190834143937169,0.0653317504743825,27,"ATM; CDC25A; CHEK1; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; UBA52; UBC"
"R-HSA-5334118","DNA methylation",0.0699000620863987,0.037961372798111,0.0655707159255257,13,"DNMT3B; H2AFV; H2AFZ; H3F3A; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; UHRF1"
"R-HSA-5362768","Hh mutants that don't undergo autocatalytic processing are degraded by ERAD",-0.0356766900784233,0.0193948246387261,0.0658423586330239,26,"ERLEC1; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; SYVN1; UBA52; UBC"
"R-HSA-5387390","Hh mutants abrogate ligand secretion",-0.0356766900784233,0.0193948246387261,0.0658423586330239,26,"ERLEC1; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; SYVN1; UBA52; UBC"
"R-HSA-5678895","Defective CFTR causes cystic fibrosis",-0.0353220686638583,0.0193116072741777,0.0673907734473155,29,"CFTR; DERL1; ERLEC1; ERLIN2; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; RNF185; UBA52; UBC"
"R-HSA-2173793","Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer",0.066170641341799,0.0362834050481587,0.0681949560649482,22,"CCNK; CCNT1; CCNT2; CDK8; CDK9; CDKN2B; E2F5; HDAC1; MYC; NCOR1; NCOR2; PARP1; PPM1A; RBL1; SKIL; SMAD3; SMAD7; SNW1; TFDP1; TRIM33; UBA52; UBC"
"R-HSA-6803529","FGFR2 alternative splicing",-0.0619803857496886,0.0340498571426279,0.0687158758016641,12,"GTF2F2; HNRNPF; NCBP1; NCBP2; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L"
"R-HSA-5620912","Anchoring of the basal body to the plasma membrane",0.0737290117123835,0.0405500763125858,0.0690303185896637,41,"AHI1; ALMS1; C2CD3; CC2D2A; CDK5RAP2; CENPJ; CEP135; CEP164; CEP192; CEP250; CEP290; CEP41; CEP57; CEP63; CEP72; CEP76; CEP89; CKAP5; CNTRL; CSNK1D; DCTN3; DYNC1H1; HAUS1; HAUS2; HAUS4; HAUS5; HSP90AA1; IQCB1; KIF24; MAPRE1; MARK4; MKS1; NDE1; NEDD1; NEK2; NINL; NPHP1; NPHP4; ODF2; PAFAH1B1; PCM1"
"R-HSA-72202","Transport of Mature Transcript to Cytoplasm",-0.0476200078213029,0.0263369042056056,0.070589453265745,40,"AAAS; CASC3; CDC40; CHTOP; CPSF1; CPSF2; CPSF3; CPSF4; DDX39B; DHX38; EIF4E; FYTTD1; GLE1; MAGOHB; NCBP1; NCBP2; NDC1; NUP107; NUP205; NUP214; NUP35; NUP37; NUP43; NUP50; NUP54; NUP62; NUP85; NUP88; NUP93; NXF1; POM121; POM121C; RAE1; RANBP2; RNPS1; SEH1L; SLU7; SRSF4; SRSF7; SRSF9"
"R-HSA-400042","Adrenaline,noradrenaline inhibits insulin secretion",0.0833629374773134,0.0462742523668165,0.0716245434434384,14,"ADCY6; ADRA2C; CACNA1C; CACNA1D; CACNB3; GNAI2; GNB2; GNB3; GNB4; GNB5; GNG11; GNG4; GNG5; GNG7"
"R-HSA-2022928","HS-GAG biosynthesis",-0.143447813498104,0.0797147312466173,0.0719373347990271,12,"EXT1; EXT2; GLCE; GPC5; HS3ST1; HS3ST3B1; HS3ST5; HS6ST3; HSPG2; NDST1; SDC2; SDC3"
"R-HSA-9020702","Interleukin-1 signaling",-0.0386088875833463,0.0216338002777438,0.0743171611498282,30,"APP; BTRC; IL1R1; IL1RAP; IRAK2; MAP2K6; MAP3K3; MAP3K7; MAP3K8; NFKB1; NFKBIA; NFKBIB; NKIRAS1; NOD1; PELI2; PELI3; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13"
"R-HSA-6814122","Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding",0.080923970958881,0.0454088380582752,0.0747297638032656,18,"CCT3; CCT4; CCT5; CCT6B; CCT8; CSNK2A2; GNAI2; GNAO1; GNAZ; GNB2; GNB3; GNB4; GNB5; GNG11; GNG4; GNG5; GNG7; RGS9"
"R-HSA-180585","Vif-mediated degradation of APOBEC3G",-0.0343806880217507,0.0194177602626305,0.0766306554367393,26,"APOBEC3G; CUL5; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; UBA52; UBC"
"R-HSA-165159","mTOR signalling",0.0904978206721742,0.0514526116451483,0.0786016863996701,22,"AKT1; AKT2; CAB39; CAB39L; EEF2K; EIF4B; EIF4E; EIF4EBP1; LAMTOR3; LAMTOR4; LAMTOR5; MLST8; MTOR; PPM1A; PRKAA2; PRKAB2; PRKAG2; RPS6KB1; RPTOR; SLC38A9; STRADB; TSC1"
"R-HSA-2122947","NOTCH1 Intracellular Domain Regulates Transcription",-0.057343875027861,0.0328889888147259,0.0812361102837081,22,"CDK8; HDAC1; HDAC2; HDAC3; HDAC4; HDAC5; HES1; HEY2; HIF1A; KAT2B; MAML1; MYC; NCOR1; NCOR2; NOTCH1; RBPJ; SKP1; SNW1; TLE3; TLE4; UBA52; UBC"
"R-HSA-6783589","Interleukin-6 family signaling",-0.104361056111839,0.0601764790008159,0.0828737424980201,10,"CBL; CRLF1; IL6ST; JAK1; JAK2; LIFR; OSMR; PTPN11; STAT3; TYK2"
"R-HSA-2129379","Molecules associated with elastic fibres",0.157209313480614,0.0918549211690334,0.0869896224588023,16,"BMP2; BMP4; EFEMP1; FBLN1; FBLN2; ITGA8; ITGAV; ITGB3; ITGB5; LTBP1; LTBP2; LTBP4; MFAP3; TGFB1; TGFB2; TGFB3"
"R-HSA-70614","Amino acid synthesis and interconversion (transamination)",0.302279414571529,0.177240225315351,0.088105196728967,16,"ASNS; ASPA; FOLH1; GOT2; GPT; NAALAD2; NAT8L; OAT; PHGDH; PSAT1; PSPH; PYCR1; PYCR2; SERINC1; SERINC3; SERINC5"
"R-HSA-73863","RNA Polymerase I Transcription Termination",0.0581020800502757,0.0340732080010515,0.0881546909291447,24,"CD3EAP; CDK7; ERCC2; ERCC3; GTF2H1; GTF2H2; GTF2H3; GTF2H4; POLR1A; POLR1B; POLR1C; POLR1D; POLR1E; POLR2E; POLR2H; POLR2K; POLR2L; TAF1A; TAF1B; TAF1C; TAF1D; TTF1; UBTF; ZNRD1"
"R-HSA-446728","Cell junction organization",-0.11245085511948,0.0659540410715189,0.0881966439929248,25,"CADM3; CD151; CDH1; CDH10; CDH13; CDH18; CDH3; CDH4; CDH6; CDH8; CDH9; CLDN1; CLDN11; CLDN12; CLDN15; CLDN16; CTNNA1; F11R; FBLIM1; FLNC; ILK; ITGA6; JUP; LAMB3; LIMS1"
"R-HSA-5655253","Signaling by FGFR2 in disease",-0.0434940397437111,0.0255123165022826,0.0882270326228421,23,"FGF1; FGF10; FGF17; FGF5; FGF9; FGFR2; GAB1; GRB2; GTF2F2; KRAS; NCBP1; NCBP2; PIK3CA; PIK3R1; PLCG1; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L"
"R-HSA-1614635","Sulfur amino acid metabolism",-0.145816237291714,0.0855349210074386,0.0882397935778566,18,"ADI1; ADO; AHCY; APIP; BHMT; BHMT2; CBS; CDO1; CSAD; ENOPH1; MRI1; MTAP; MTR; MTRR; SLC25A10; SUOX; TST; TSTD1"
"R-HSA-9006925","Intracellular signaling by second messengers",-0.0464702361869515,0.0278848092295441,0.0956124293761817,32,"ADCY3; ADCY6; ADCY7; AGO2; AHCYL1; AKT1; AKT2; AKT3; ATN1; BTC; CALM1; CAMK4; CASP9; CBX4; CDKN1A; CDKN1B; CNOT6L; CREB1; CSNK2A2; EGF; EGFR; EGR1; ERBB2; ERBB3; ERBB4; ESR1; ESR2; EZH2; FGF1; FGF10; FGF17; FGF5"
"R-HSA-5663220","RHO GTPases Activate Formins",0.0732123686951819,0.0440608473482173,0.0965890656762994,30,"ACTB; ACTG1; BUB3; CENPC; CENPE; CENPH; CENPL; CENPN; CENPP; CENPQ; CENPT; CKAP5; CLIP1; DAAM1; DIAPH1; DSN1; DVL1; DVL2; DYNC1H1; DYNC1LI2; DYNLL2; FMNL2; FMNL3; INCENP; ITGB3BP; KIF2A; MAD1L1; MAPRE1; MIS12; NDE1"
"R-HSA-69229","Ubiquitin-dependent degradation of Cyclin D1",-0.0323955817261555,0.0194992162713046,0.096637421699422,24,"PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; UBA52; UBC"
"R-HSA-75815","Ubiquitin-dependent degradation of Cyclin D",-0.0323955817261555,0.0194992162713046,0.096637421699422,24,"PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; UBA52; UBC"
"R-HSA-5654743","Signaling by FGFR4",-0.0418044808564436,0.0251808360494843,0.0968801599772697,21,"CBL; FGF1; FGF17; FGF9; GAB1; GRB2; KLB; KRAS; MAPK1; MAPK3; MKNK1; PIK3CA; PIK3R1; PLCG1; PPP2CA; PPP2R1A; PTPN11; SPRY2; SRC; UBA52; UBC"
"R-HSA-2682334","EPH-Ephrin signaling",-0.0624604919208979,0.0378942573554055,0.0992944398535471,41,"ACTB; ACTG1; ACTR2; ADAM10; AP2A2; AP2B1; AP2M1; ARHGEF28; ARPC1A; ARPC1B; ARPC2; ARPC3; ARPC4; CFL1; CLTA; CLTCL1; EFNA3; EFNA5; EFNB2; EFNB3; EPHA10; EPHA2; EPHA3; EPHA5; EPHA7; EPHB1; EPHB2; EPHB4; FYN; GIT1; ITSN1; KALRN; LIMK1; LIMK2; LYN; MMP2; MYH10; MYH11; MYH14; MYH9; MYL12A"
"R-HSA-1855204","Synthesis of IP3 and IP4 in the cytosol",0.115127207028762,0.0698969748618954,0.0995377879424403,12,"CALM1; INPP5B; INPP5D; ITPKB; PLCB1; PLCB3; PLCD4; PLCE1; PLCG1; PLCG2; PLCH1; PTEN"
"R-HSA-5610783","Degradation of GLI2 by the proteasome",-0.0311710551861998,0.0189353559844045,0.0997261526831024,29,"BTRC; GSK3B; PRKACA; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; SKP1; SUFU; UBA52; UBC"
"R-HSA-5610785","GLI3 is processed to GLI3R by the proteasome",-0.0311710551861998,0.0189353559844045,0.0997261526831024,29,"BTRC; GSK3B; PRKACA; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; SKP1; SUFU; UBA52; UBC"
"R-HSA-168254","Influenza Infection",0.0406359391697544,0.0247094915315752,0.100063105596553,35,"AAAS; CALR; CANX; CLTA; CPSF4; DNAJC3; GTF2F2; HSP90AA1; IPO5; KPNA3; KPNA4; KPNA5; NDC1; NUP107; NUP205; NUP214; NUP35; NUP37; NUP43; NUP50; NUP54; NUP62; NUP85; NUP88; NUP93; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L; POM121; POM121C"
"R-HSA-113418","Formation of the Early Elongation Complex",0.0472978520942023,0.0288837558060374,0.101520965164936,22,"CDK7; ERCC2; ERCC3; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; NCBP1; NCBP2; NELFA; NELFB; NELFCD; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L; SUPT5H"
"R-HSA-167158","Formation of the HIV-1 Early Elongation Complex",0.0472978520942023,0.0288837558060374,0.101520965164936,22,"CDK7; ERCC2; ERCC3; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; NCBP1; NCBP2; NELFA; NELFB; NELFCD; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L; SUPT5H"
"R-HSA-373755","Semaphorin interactions",-0.0669983987322628,0.0410451836912621,0.102614531426289,40,"ARHGEF11; ARHGEF12; CDK5; CDK5R1; CFL1; DPYSL4; DPYSL5; ERBB2; FARP2; FES; FYN; GSK3B; HSP90AA1; HSP90AB1; ITGA1; LIMK1; LIMK2; MET; MYH10; MYH11; MYH14; MYH9; NRP1; PAK1; PAK2; PLXNA1; PLXNA2; PLXNA4; PLXNB1; PLXNC1; PLXND1; RHOB; RND1; ROCK1; ROCK2; SEMA3A; SEMA3E; SEMA4D; SEMA6A; TLN1"
"R-HSA-111885","Opioid Signalling",0.0480485190688256,0.0294626879598048,0.102927028802094,35,"ADCY3; ADCY6; ADCY7; AHCYL1; CALM1; CAMK4; CDK5; CREB1; GNAI2; GNAO1; GNAZ; GNB2; GNB3; GNB4; GNB5; GNG11; GNG4; GNG5; GNG7; ITPR2; ITPR3; MAPK1; PDE1B; PDE1C; PDE4A; PDE4B; PDE4C; PDE4D; PLCB1; PLCB3; POMC; PPP2CA; PPP2R1A; PPP2R1B; PPP2R5D"
"R-HSA-5654708","Downstream signaling of activated FGFR3",-0.0580354259717509,0.0357797870045993,0.104799689084905,11,"FGF1; FGF17; FGF5; FGF9; GAB1; GRB2; KRAS; PIK3CA; PIK3R1; PLCG1; PTPN11"
"R-HSA-383280","Nuclear Receptor transcription pathway",-0.127557459213493,0.0787054529087892,0.105083270381887,19,"ESR1; ESR2; NR1D1; NR1D2; NR1H2; NR1H3; NR1I3; NR2C1; NR2C2AP; NR2E1; NR2F1; NR4A1; NR6A1; NRBF2; RARG; RORA; RORB; RXRA; RXRG"
"R-HSA-8862803","Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models",0.0991188883177888,0.0612507220518557,0.105609057180308,15,"APP; BCL2L11; CAPN1; CAPN2; CAST; CDC25A; CDC25B; CDK5; CDK5R1; GOLGA2; JUN; LMNB1; PRDX2; SOD2; YWHAE"
"R-HSA-8863678","Neurodegenerative Diseases",0.0991188883177888,0.0612507220518557,0.105609057180308,15,"APP; BCL2L11; CAPN1; CAPN2; CAST; CDC25A; CDC25B; CDK5; CDK5R1; GOLGA2; JUN; LMNB1; PRDX2; SOD2; YWHAE"
"R-HSA-5654738","Signaling by FGFR2",-0.0360909772584057,0.0225951520729032,0.110201406191203,31,"CBL; FGF1; FGF10; FGF17; FGF5; FGF9; FGFR2; GAB1; GRB2; GTF2F2; HNRNPF; KRAS; MAPK1; MAPK3; MKNK1; NCBP1; NCBP2; PIK3CA; PIK3R1; PLCG1; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L; PPP2CA; PPP2R1A; PTPN11"
"R-HSA-418594","G alpha (i) signalling events",-0.0652594153579721,0.0410435947870414,0.111834257788305,21,"ABCA4; ACKR3; ADCY3; ADCY6; ADCY7; ADRA2C; AGT; AHCYL1; AKR1C1; AKR1C3; ANXA1; APLNR; APOB; APOE; APP; BCO2; C5; CALM1; CAMK4; CAMKMT; CCR1"
"R-HSA-2559584","Formation of Senescence-Associated Heterochromatin Foci (SAHF)",-0.100139195154911,0.0630827696040443,0.112416314629687,12,"ASF1A; CABIN1; CDKN1A; EP400; H1F0; HIST1H1A; HIST1H1C; HIST1H1D; HMGA1; LMNB1; RB1; TP53"
"R-HSA-1630316","Glycosaminoglycan metabolism",0.0978384070407279,0.061989552770451,0.114495609831751,35,"ABCC5; ACAN; ARSB; B3GALT6; B3GAT1; B3GAT2; B4GALT2; B4GALT3; B4GALT4; B4GALT5; B4GALT6; CD44; CHPF; CHST1; CHST11; CHST12; CHST3; CHST6; CHST9; CHSY3; CSGALNACT1; CSGALNACT2; DCN; DSE; EXT1; EXT2; FMOD; GLB1; GLCE; GPC5; HAS1; HAS2; HEXA; HEXB; HMMR"
"R-HSA-5654733","Negative regulation of FGFR4 signaling",-0.0445919822466731,0.0282842941140397,0.114896025140216,16,"CBL; FGF1; FGF17; FGF9; GRB2; KLB; MAPK1; MAPK3; MKNK1; PPP2CA; PPP2R1A; PTPN11; SPRY2; SRC; UBA52; UBC"
"R-HSA-5654716","Downstream signaling of activated FGFR4",0.0608634864521943,0.0390407494047008,0.119002696597962,11,"FGF1; FGF17; FGF9; GAB1; GRB2; KLB; KRAS; PIK3CA; PIK3R1; PLCG1; PTPN11"
"R-HSA-5619115","Disorders of transmembrane transporters",0.0329444658268864,0.0211463694503965,0.119250936161105,29,"ABCC8; CFTR; DERL1; ERLEC1; ERLIN2; KCNJ11; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; RNF185"
"R-HSA-211733","Regulation of activated PAK-2p34 by proteasome mediated degradation",-0.0302251514327545,0.019426244590577,0.119733618311673,25,"PAK2; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; UBA52; UBC"
"R-HSA-169911","Regulation of Apoptosis",-0.0302106014571994,0.0194180275643917,0.119755239544228,27,"OMA1; OPA1; PAK2; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; UBA52; UBC"
"R-HSA-77595","Processing of Intronless Pre-mRNAs",0.100624615749517,0.065114298496647,0.122260756550552,12,"CPSF1; CPSF2; CPSF3; CPSF4; CPSF7; CSTF1; CSTF2T; NCBP1; NCBP2; PAPOLA; PCF11; SYMPK"
"R-HSA-5625740","RHO GTPases activate PKNs",0.0538484406922946,0.0348812878579916,0.122645764070585,24,"H2AFV; H2AFZ; H3F3A; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; KDM4C; MYH10; MYH11; MYH14; MYH9; PAK1; PPP1CB; PPP1R14A; RHOB; YWHAE; YWHAG; YWHAQ; YWHAZ"
"R-HSA-69481","G2/M Checkpoints",0.0452153101380154,0.0294419623092668,0.124601235956673,30,"ATM; ATRIP; BARD1; BLM; BRIP1; CDC25A; CDC7; CDK2; CHEK1; DBF4; DNA2; EXO1; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; MCM2; MCM3; MCM4; MCM6; MCM7; MCM8; MDC1; NBN; ORC2; ORC4; ORC5; PSMA1"
"R-HSA-4641258","Degradation of DVL",-0.0297524979607233,0.0193855073949064,0.124837764039831,28,"CUL3; DACT1; DVL1; DVL2; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; UBA52; UBC"
"R-HSA-8852276","The role of GTSE1 in G2/M progression after G2 checkpoint",-0.0290513972773955,0.018934436353906,0.124952079069777,30,"CDKN1A; HSP90AA1; HSP90AB1; MAPRE1; PLK1; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; TP53; UBA52; UBC"
"R-HSA-877300","Interferon gamma signaling",-0.0792407788914168,0.0516783437018048,0.125190639170478,25,"CAMK2B; CAMK2D; CD44; CIITA; GBP3; HLA-A; HLA-B; HLA-C; HLA-E; ICAM1; IFNGR1; IRF2; IRF5; IRF6; IRF9; JAK1; JAK2; OAS1; OAS2; OAS3; PML; PRKCD; PTAFR; PTPN11; PTPN2"
"R-HSA-69473","G2/M DNA damage checkpoint",-0.0422687851998954,0.0278168830326513,0.128627362088096,33,"ATM; ATRIP; BARD1; BLM; BRIP1; CHEK1; DNA2; EXO1; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; MDC1; NBN; RAD1; RAD50; RAD9A; RFC2; RFC3; RFC4; RFC5; RMI1; RMI2; RNF8; RPA1; RPA2; RPA3; TOP3A; TOPBP1; TP53; UBE2N"
"R-HSA-5693607","Processing of DNA double-strand break ends",0.0419635998039021,0.0277199908320363,0.130066709556314,34,"ATM; ATRIP; BARD1; BLM; BRIP1; CCNA1; CCNA2; CDK2; CHEK1; DNA2; EXO1; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; MDC1; NBN; PPP4C; RAD1; RAD50; RAD9A; RFC2; RFC3; RFC4; RFC5; RMI1; RMI2; RNF8; RPA1; RPA2; RPA3; SIRT6"
"R-HSA-198933","Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell",-0.116036480086765,0.0789038181772252,0.141397523246581,18,"CD200; CD200R1; CD22; CD300A; CD81; CD8A; CDH1; CLEC2D; CLEC4G; COLEC12; CXADR; HLA-A; HLA-B; HLA-C; HLA-E; ICAM1; ICAM3; ICAM5"
"R-HSA-212436","Generic Transcription Pathway",0.0500482293507046,0.0341859066992729,0.143193453268883,30,"ACTL6A; ACTL6B; AGO2; AIFM2; AKT1; AKT2; AKT3; APOE; ARID1A; ARID3A; ASH2L; ATAD2; ATM; ATRIP; AXIN1; BARD1; BCL2L11; BCL6; BID; BLM; BMP2; BRD7; BRIP1; BRPF1; CARM1; CASP10; CBX3; CBX4; CCNA1; CCNA2"
"R-HSA-419037","NCAM1 interactions",-0.112246177951794,0.0766979931980278,0.143335373335154,13,"CACNA1C; CACNA1D; CACNA1G; CACNA1I; CACNB3; CNTN2; COL4A4; COL6A1; COL6A2; COL6A3; GFRA1; GFRA2; NCAN"
"R-HSA-400685","Sema4D in semaphorin signaling",-0.0941740501426614,0.0644521175073346,0.143974968022987,16,"ARHGEF11; ARHGEF12; ERBB2; LIMK1; LIMK2; MET; MYH10; MYH11; MYH14; MYH9; PLXNB1; RHOB; RND1; ROCK1; ROCK2; SEMA4D"
"R-HSA-5654687","Downstream signaling of activated FGFR1",-0.0492240773857837,0.0337996218246421,0.145295905247817,16,"FGF1; FGF10; FGF17; FGF5; FGF9; FGFR1; FLRT1; FLRT2; GAB1; GRB2; KL; KRAS; PIK3CA; PIK3R1; PLCG1; PTPN11"
"R-HSA-212300","PRC2 methylates histones and DNA",0.0532228089840511,0.0366126419534758,0.146036987879912,17,"AEBP2; DNMT3B; EZH2; H2AFV; H2AFZ; H3F3A; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; MTF2; PHF19; RBBP4"
"R-HSA-2142753","Arachidonic acid metabolism",-0.116860742335792,0.0806541877732424,0.147362430250871,23,"ABCC1; AKR1C3; ALOX5; ALOX5AP; CBR1; CYP1B1; CYP2C8; CYP2J2; CYP2U1; CYP4F11; CYP4F3; EPHX2; FAAH; GPX1; GPX4; HPGD; LTA4H; PON3; PTGDS; PTGR1; PTGR2; PTGS1; TBXAS1"
"R-HSA-69231","Cyclin D associated events in G1",0.0444134345027182,0.0306642362055254,0.147511096137423,25,"CCND2; CCND3; CDK6; CDK7; CDKN1A; CDKN1B; CDKN2B; CDKN2C; CKS1B; E2F1; E2F5; JAK2; LYN; PPP2CA; PPP2R1A; PPP2R1B; RB1; RBL1; RBL2; SKP1; SKP2; SRC; TFDP1; UBA52; UBC"
"R-HSA-69236","G1 Phase",0.0444134345027182,0.0306642362055254,0.147511096137423,25,"CCND2; CCND3; CDK6; CDK7; CDKN1A; CDKN1B; CDKN2B; CDKN2C; CKS1B; E2F1; E2F5; JAK2; LYN; PPP2CA; PPP2R1A; PPP2R1B; RB1; RBL1; RBL2; SKP1; SKP2; SRC; TFDP1; UBA52; UBC"
"R-HSA-204005","COPII (Coat Protein 2) Mediated Vesicle Transport",-0.0853171079182552,0.059737681090384,0.153235496253889,41,"ANKRD28; BET1; CD59; CNIH3; CSNK1D; CTSC; CTSZ; F5; GOLGA2; GORASP1; GOSR2; GRIA1; LMAN1; MCFD2; NAPA; NAPB; NAPG; NSF; PPP6C; PPP6R1; PPP6R3; PREB; RAB1A; SAR1B; SCFD1; SEC13; SEC23A; SEC23IP; SEC24C; SERPINA1; STX17; TFG; TGFA; TMED10; TMED2; TRAPPC1; TRAPPC10; TRAPPC4; TRAPPC5; TRAPPC6A; USO1"
"R-HSA-216083","Integrin cell surface interactions",0.0879305733318651,0.0616251243220195,0.153619558049882,30,"BSG; CD44; CDH1; COL16A1; COL18A1; COL23A1; COL4A4; F11R; HSPG2; ICAM1; ICAM3; ICAM5; ITGA1; ITGA2; ITGA3; ITGA4; ITGA6; ITGA8; ITGA9; ITGAE; ITGAV; ITGAX; ITGB2; ITGB3; ITGB5; JAM2; KDR; LUM; TNC; VCAM1"
"R-HSA-392170","ADP signalling through P2Y purinoceptor 12",0.0735961476866015,0.0517765511529028,0.15519513132181,10,"GNAI2; GNB2; GNB3; GNB4; GNB5; GNG11; GNG4; GNG5; GNG7; P2RY12"
"R-HSA-71291","Metabolism of amino acids and derivatives",-0.103110249236726,0.0729380121639646,0.157458940215069,40,"AADAT; AASS; ACAD8; ACADSB; ACAT1; ADI1; ADO; AGMAT; AHCY; AIMP1; ALDH4A1; ALDH6A1; ALDH7A1; ALDH9A1; AMD1; AMDHD1; APIP; ARG2; ASL; ASNS; ASPA; ASRGL1; ASS1; AUH; AZIN1; BBOX1; BCAT1; BCKDHA; BCKDHB; BHMT; BHMT2; CBS; CDO1; CHDH; CKMT2; CPS1; CSAD; DBT; DCT; DDO"
"R-HSA-5654696","Downstream signaling of activated FGFR2",-0.048810097518754,0.0345310089554485,0.157504367755256,13,"FGF1; FGF10; FGF17; FGF5; FGF9; FGFR2; GAB1; GRB2; KRAS; PIK3CA; PIK3R1; PLCG1; PTPN11"
"R-HSA-5576891","Cardiac conduction",-0.0620745638737342,0.0439233015907261,0.15758251147804,28,"ABCC9; AHCYL1; ASPH; ATP1A1; ATP1A3; ATP1B1; ATP1B2; ATP1B3; ATP2A2; ATP2B1; ATP2B4; CACNA1C; CACNA1D; CACNA2D1; CACNA2D3; CACNB3; CACNG2; CACNG4; CALM1; CAMK2B; CAMK2D; CORIN; DMPK; FKBP1B; FXYD6; ITPR2; ITPR3; KAT2B"
"R-HSA-1221632","Meiotic synapsis",0.0516309572264375,0.03684780534218,0.161155796505917,25,"ACD; DIDO1; H2AFV; H2AFZ; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; HSPA2; LMNB1; POT1; RAD21; SMC3; STAG3; SUN2; SYCP3; SYNE1; SYNE2; TERF1; TINF2; UBE2I"
"R-HSA-73886","Chromosome Maintenance",-0.0401611412177294,0.0292816011687449,0.17020398159025,30,"ACD; CENPC; CENPH; CENPL; CENPN; CENPP; CENPQ; CENPT; DNA2; FEN1; H2AFV; H2AFZ; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; ITGB3BP; LIG1; MIS18BP1; NPM1; POLA2; POLD2; POLD3; POLE; POT1; PRIM1"
"R-HSA-2219528","PI3K/AKT Signaling in Cancer",0.0379190571690557,0.027753544566042,0.171851725670641,35,"AKT1; AKT2; AKT3; BTC; CASP9; CDKN1A; CDKN1B; CREB1; EGF; EGFR; ERBB2; ERBB3; ERBB4; ESR1; ESR2; FGF1; FGF10; FGF17; FGF5; FGF9; FGFR1; FGFR2; FOXO1; FYN; GAB1; GRB2; GSK3B; KIT; KITLG; KL; KLB; MDM2; MET; MLST8; MTOR"
"R-HSA-167242","Abortive elongation of HIV-1 transcript in the absence of Tat",-0.0441409608838836,0.0330233906593076,0.18133447962448,15,"GTF2F2; NCBP1; NCBP2; NELFA; NELFB; NELFCD; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L; SUPT5H"
"R-HSA-180534","Vpu mediated degradation of CD4",-0.0254406460648214,0.0191670863001184,0.184406489374605,27,"BTRC; CD4; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; SKP1; UBA52; UBC"
"R-HSA-1660499","Synthesis of PIPs at the plasma membrane",0.0715600395084702,0.0541260541540341,0.186134956460065,30,"ARF1; INPP4B; INPP5D; MTMR2; MTMR3; MTMR6; MTMR9; PI4K2A; PI4K2B; PIK3C2B; PIK3C2G; PIK3CA; PIK3CB; PIK3CD; PIK3R1; PIK3R5; PIP4K2A; PIP5K1A; PLEKHA1; PLEKHA2; PLEKHA3; PLEKHA5; PLEKHA6; PLEKHA8; PTEN; PTPN13; RAB14; RAB5A; RUFY1; SYNJ2"
"R-HSA-162710","Synthesis of glycosylphosphatidylinositol (GPI)",0.233185901755595,0.178890932545121,0.19240111984913,12,"DPM2; PIGB; PIGC; PIGF; PIGG; PIGH; PIGM; PIGN; PIGP; PIGV; PIGX; PIGZ"
"R-HSA-2644602","Signaling by NOTCH1 PEST Domain Mutants in Cancer",-0.039979697941956,0.0312018882153535,0.200080227049365,26,"ADAM10; ADAM17; CDK8; DLL4; HDAC1; HDAC2; HDAC3; HDAC4; HDAC5; HES1; HEY2; JAG1; KAT2B; MAML1; MIB1; MYC; NCOR1; NCOR2; NOTCH1; PSEN1; PSEN2; RBPJ; SKP1; SNW1; UBA52; UBC"
"R-HSA-2644603","Signaling by NOTCH1 in Cancer",-0.039979697941956,0.0312018882153535,0.200080227049365,26,"ADAM10; ADAM17; CDK8; DLL4; HDAC1; HDAC2; HDAC3; HDAC4; HDAC5; HES1; HEY2; JAG1; KAT2B; MAML1; MIB1; MYC; NCOR1; NCOR2; NOTCH1; PSEN1; PSEN2; RBPJ; SKP1; SNW1; UBA52; UBC"
"R-HSA-2644606","Constitutive Signaling by NOTCH1 PEST Domain Mutants",-0.039979697941956,0.0312018882153535,0.200080227049365,26,"ADAM10; ADAM17; CDK8; DLL4; HDAC1; HDAC2; HDAC3; HDAC4; HDAC5; HES1; HEY2; JAG1; KAT2B; MAML1; MIB1; MYC; NCOR1; NCOR2; NOTCH1; PSEN1; PSEN2; RBPJ; SKP1; SNW1; UBA52; UBC"
"R-HSA-2894858","Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer",-0.039979697941956,0.0312018882153535,0.200080227049365,26,"ADAM10; ADAM17; CDK8; DLL4; HDAC1; HDAC2; HDAC3; HDAC4; HDAC5; HES1; HEY2; JAG1; KAT2B; MAML1; MIB1; MYC; NCOR1; NCOR2; NOTCH1; PSEN1; PSEN2; RBPJ; SKP1; SNW1; UBA52; UBC"
"R-HSA-2894862","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants",-0.039979697941956,0.0312018882153535,0.200080227049365,26,"ADAM10; ADAM17; CDK8; DLL4; HDAC1; HDAC2; HDAC3; HDAC4; HDAC5; HES1; HEY2; JAG1; KAT2B; MAML1; MIB1; MYC; NCOR1; NCOR2; NOTCH1; PSEN1; PSEN2; RBPJ; SKP1; SNW1; UBA52; UBC"
"R-HSA-212676","Dopamine Neurotransmitter Release Cycle",-0.123149605455071,0.0964683673085874,0.201750503832093,11,"CPLX1; LIN7A; LIN7B; LIN7C; PPFIA1; PPFIA2; PPFIA4; SLC18A2; SYN3; SYT1; VAMP2"
"R-HSA-606279","Deposition of new CENPA-containing nucleosomes at the centromere",-0.0419025963712868,0.0328264566060772,0.201782867748687,23,"CENPC; CENPH; CENPL; CENPN; CENPP; CENPQ; CENPT; H2AFV; H2AFZ; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; ITGB3BP; MIS18BP1; NPM1; RBBP4; RSF1; RUVBL1"
"R-HSA-774815","Nucleosome assembly",-0.0419025963712868,0.0328264566060772,0.201782867748687,23,"CENPC; CENPH; CENPL; CENPN; CENPP; CENPQ; CENPT; H2AFV; H2AFZ; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; ITGB3BP; MIS18BP1; NPM1; RBBP4; RSF1; RUVBL1"
"R-HSA-450408","AUF1 (hnRNP D0) binds and destabilizes mRNA",-0.0248258266022454,0.0194851301629114,0.202631210790671,26,"HNRNPD; HSPA8; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; UBA52; UBC"
"R-HSA-456926","Thrombin signalling through proteinase activated receptors (PARs)",0.0477677684698348,0.0375575990600635,0.203425132026624,17,"ARRB1; ARRB2; F2R; GNA12; GNA13; GNA15; GNB2; GNB3; GNB4; GNB5; GNG11; GNG4; GNG5; GNG7; MAPK1; MAPK3; SRC"
"R-HSA-157579","Telomere Maintenance",-0.0343868427902207,0.0271028565461565,0.204529011819314,32,"ACD; DNA2; FEN1; H2AFV; H2AFZ; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; LIG1; POLA2; POLD2; POLD3; POLE; POT1; PRIM1; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3; RUVBL1; RUVBL2; TERF1; TINF2"
"R-HSA-176033","Interactions of Vpr with host cellular proteins",-0.0376410233410675,0.0300026815269605,0.209628130324919,22,"AAAS; BANF1; HMGA1; NDC1; NUP107; NUP205; NUP214; NUP35; NUP37; NUP43; NUP50; NUP54; NUP62; NUP85; NUP88; NUP93; POM121; POM121C; PSIP1; RAE1; RANBP2; SEH1L"
"R-HSA-180910","Vpr-mediated nuclear import of PICs",-0.0376410233410675,0.0300026815269605,0.209628130324919,22,"AAAS; BANF1; HMGA1; NDC1; NUP107; NUP205; NUP214; NUP35; NUP37; NUP43; NUP50; NUP54; NUP62; NUP85; NUP88; NUP93; POM121; POM121C; PSIP1; RAE1; RANBP2; SEH1L"
"R-HSA-445095","Interaction between L1 and Ankyrins",0.165669558908866,0.132654406153461,0.211708625363848,16,"ANK1; KCNQ2; KCNQ3; SCN11A; SCN1A; SCN1B; SCN4B; SCN5A; SCN7A; SCN8A; SCN9A; SPTB; SPTBN1; SPTBN2; SPTBN4; SPTBN5"
"R-HSA-975577","N-Glycan antennae elongation",0.127102434194912,0.102310671029704,0.214119090918579,12,"B4GALT2; B4GALT3; B4GALT4; B4GALT5; B4GALT6; MGAT4A; MGAT4C; MGAT5; ST3GAL4; ST6GAL1; ST8SIA3; ST8SIA6"
"R-HSA-163685","Integration of energy metabolism",-0.0432641062152931,0.0348698415289641,0.214705002030882,32,"ABCC8; ACACA; ACACB; ACLY; ADCY3; ADCY6; ADCY7; ADIPOR1; ADRA2C; AHCYL1; AKAP5; CACNA1A; CACNA1C; CACNA1D; CACNA1E; CACNB3; FASN; GNA15; GNAI2; GNB2; GNB3; GNB4; GNB5; GNG11; GNG4; GNG5; GNG7; IQGAP1; ITPR2; ITPR3; KCNB1; KCNC2"
"R-HSA-72613","Eukaryotic Translation Initiation",0.0517340462396604,0.0420192629292475,0.218248696817042,36,"EIF2B1; EIF2B2; EIF2B3; EIF2B4; EIF2B5; EIF2S1; EIF3A; EIF3B; EIF3C; EIF3E; EIF3F; EIF3H; EIF3I; EIF3L; EIF4A1; EIF4A2; EIF4B; EIF4E; EIF4EBP1; RPL10A; RPL12; RPL13; RPL14; RPL15; RPL17; RPL23; RPL26; RPL26L1; RPL27; RPL27A; RPL29; RPL3; RPL31; RPL35; RPL36; RPL36AL"
"R-HSA-72737","Cap-dependent Translation Initiation",0.0517340462396604,0.0420192629292475,0.218248696817042,36,"EIF2B1; EIF2B2; EIF2B3; EIF2B4; EIF2B5; EIF2S1; EIF3A; EIF3B; EIF3C; EIF3E; EIF3F; EIF3H; EIF3I; EIF3L; EIF4A1; EIF4A2; EIF4B; EIF4E; EIF4EBP1; RPL10A; RPL12; RPL13; RPL14; RPL15; RPL17; RPL23; RPL26; RPL26L1; RPL27; RPL27A; RPL29; RPL3; RPL31; RPL35; RPL36; RPL36AL"
"R-HSA-189445","Metabolism of porphyrins",0.246116968977532,0.200763819109896,0.220235178160296,11,"ALAD; BLVRA; BLVRB; COX10; CPOX; FECH; HMBS; HMOX1; HMOX2; PPOX; UROS"
"R-HSA-6796648","TP53 Regulates Transcription of DNA Repair Genes",-0.0311712487201192,0.0254375339955985,0.220423146995607,37,"ATM; CCNK; CCNT1; CCNT2; CDK12; CDK13; CDK7; CDK9; CHEK1; ELL; ERCC2; ERCC3; FANCC; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; JUN; MDC1; MLH1; MSH2; NELFA; NELFB; NELFCD; PMS2; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L; SUPT16H; SUPT5H; TP53"
"R-HSA-352230","Amino acid transport across the plasma membrane",0.199484429765792,0.163149764877037,0.221440219555408,14,"SLC16A10; SLC1A4; SLC25A29; SLC36A1; SLC36A4; SLC38A2; SLC38A3; SLC43A1; SLC6A20; SLC6A6; SLC7A1; SLC7A11; SLC7A2; SLC7A8"
"R-HSA-6809371","Formation of the cornified envelope",0.143471742885795,0.117616580435539,0.222530907263889,14,"CAPN1; DSC1; DSG2; DSP; FLG; FURIN; JUP; LIPJ; PCSK6; PERP; PKP1; PKP4; PPL; SPINK9"
"R-HSA-211859","Biological oxidations",-0.0921459817706432,0.0757320362680137,0.223704240618409,26,"ABHD10; ABHD14B; ACSM5; ACSS1; ACSS2; ADH5; AHCY; AKR7L; ALDH1A1; ALDH2; ARNT; ARNT2; AS3MT; BPHL; BPNT1; CBR3; CES3; CHAC1; CHAC2; CMBL; CNDP2; COMT; CYB5R3; CYP1B1; CYP26A1; CYP26B1"
"R-HSA-5578775","Ion homeostasis",-0.0542506886666984,0.0449510470570391,0.22747691294917,34,"ABCC9; AHCYL1; ASPH; ATP1A1; ATP1A3; ATP1B1; ATP1B2; ATP1B3; ATP2A2; ATP2B1; ATP2B4; CALM1; CAMK2B; CAMK2D; DMPK; FKBP1B; FXYD6; ITPR2; ITPR3; KCNJ11; NOS1; ORAI2; PLN; PRKACA; RYR1; RYR2; RYR3; SLC8A1; SLC8A2; SLC8A3; SRI; STIM1; TRDN; TRPC1"
"R-HSA-167169","HIV Transcription Elongation",-0.0322093957036184,0.0267301557348791,0.228209684819263,26,"CCNT1; CDK7; CDK9; ELL; ERCC2; ERCC3; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; NCBP1; NCBP2; NELFA; NELFB; NELFCD; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L; SUPT16H; SUPT5H"
"R-HSA-167200","Formation of HIV-1 elongation complex containing HIV-1 Tat",-0.0322093957036184,0.0267301557348791,0.228209684819263,26,"CCNT1; CDK7; CDK9; ELL; ERCC2; ERCC3; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; NCBP1; NCBP2; NELFA; NELFB; NELFCD; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L; SUPT16H; SUPT5H"
"R-HSA-167246","Tat-mediated elongation of the HIV-1 transcript",-0.0322093957036184,0.0267301557348791,0.228209684819263,26,"CCNT1; CDK7; CDK9; ELL; ERCC2; ERCC3; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; NCBP1; NCBP2; NELFA; NELFB; NELFCD; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L; SUPT16H; SUPT5H"
"R-HSA-8868773","rRNA processing in the nucleus and cytosol",-0.0637257346467281,0.0529026581147132,0.228363650822862,46,"BMS1; BYSL; C1D; CSNK1D; DCAF13; DDX47; DDX52; DHX37; DIMT1; EBNA1BP2; ERI1; EXOSC10; EXOSC2; EXOSC3; EXOSC4; EXOSC5; EXOSC6; EXOSC8; EXOSC9; FBL; FTSJ3; GAR1; GNL3; HEATR1; IMP4; ISG20L2; KRR1; LTV1; MPHOSPH10; MPHOSPH6; NAT10; NOB1; NOL11; NOL6; NOP10; NOP14; NOP2; NOP56; NOP58; PDCD11; PELP1; PES1; PNO1; PWP2; RCL1; RIOK2"
"R-HSA-1236382","Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants",-0.0367579600656504,0.0307332102027636,0.23168334542575,13,"CBL; CDC37; EGF; EGFR; GAB1; GRB2; HSP90AA1; KRAS; PIK3CA; PIK3R1; PLCG1; UBA52; UBC"
"R-HSA-1643713","Signaling by EGFR in Cancer",-0.0367579600656504,0.0307332102027636,0.23168334542575,13,"CBL; CDC37; EGF; EGFR; GAB1; GRB2; HSP90AA1; KRAS; PIK3CA; PIK3R1; PLCG1; UBA52; UBC"
"R-HSA-5637815","Signaling by Ligand-Responsive EGFR Variants in Cancer",-0.0367579600656504,0.0307332102027636,0.23168334542575,13,"CBL; CDC37; EGF; EGFR; GAB1; GRB2; HSP90AA1; KRAS; PIK3CA; PIK3R1; PLCG1; UBA52; UBC"
"R-HSA-8978934","Metabolism of cofactors",-0.0665649527718769,0.0556788250071367,0.23188530212269,12,"AKT1; CALM1; COQ5; COQ7; COQ9; DHFR; GCH1; HSP90AA1; NOS3; PDSS1; PDSS2; PRKG2"
"R-HSA-210991","Basigin interactions",0.121774221631846,0.102287272893977,0.233845232468836,12,"ATP1B1; ATP1B2; ATP1B3; BSG; CAV1; ITGA3; ITGA6; MAG; PPIL2; SLC16A1; SLC7A11; SLC7A8"
"R-HSA-1632852","Macroautophagy",-0.0638112590431032,0.0538067557281616,0.235648379527514,38,"AMBRA1; ATG10; ATG12; ATG13; ATG14; ATG3; ATG4C; ATG7; ATG9A; CHMP2A; CHMP2B; CHMP3; CHMP4A; CHMP4B; CHMP7; DYNLL2; GABARAPL1; LAMTOR3; LAMTOR4; LAMTOR5; MAP1LC3A; MAP1LC3B; MLST8; MTMR3; MTOR; PIK3C3; PRKAA2; PRKAB2; PRKAG2; RB1CC1; RPTOR; SLC38A9; TSC1; ULK1; UVRAG; WDR45B; WIPI1; WIPI2"
"R-HSA-977225","Amyloid fiber formation",-0.0341082919286582,0.0288930413378214,0.237800631383518,25,"APP; CALB1; CST3; FURIN; GGA2; GSN; H2AFZ; H3F3A; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; HSPG2; LYZ; MFGE8; SIAH1; SNCA; SNCAIP; TGFBI; UBA52; UBC"
"R-HSA-159231","Transport of Mature mRNA Derived from an Intronless Transcript",-0.032667988195214,0.0277546690359577,0.239184825212627,28,"AAAS; CPSF1; CPSF2; CPSF3; CPSF4; EIF4E; NCBP1; NCBP2; NDC1; NUP107; NUP205; NUP214; NUP35; NUP37; NUP43; NUP50; NUP54; NUP62; NUP85; NUP88; NUP93; NXF1; POM121; POM121C; RAE1; RANBP2; SEH1L; SYMPK"
"R-HSA-159234","Transport of Mature mRNAs Derived from Intronless Transcripts",-0.032667988195214,0.0277546690359577,0.239184825212627,28,"AAAS; CPSF1; CPSF2; CPSF3; CPSF4; EIF4E; NCBP1; NCBP2; NDC1; NUP107; NUP205; NUP214; NUP35; NUP37; NUP43; NUP50; NUP54; NUP62; NUP85; NUP88; NUP93; NXF1; POM121; POM121C; RAE1; RANBP2; SEH1L; SYMPK"
"R-HSA-373752","Netrin-1 signaling",-0.0477484572930731,0.0407003158141836,0.240726972113858,36,"ABLIM1; ABLIM2; ABLIM3; DCC; DOCK1; DSCAM; DSCAML1; FYN; MAPK11; MAPK12; MAPK13; MAPK14; MAPK8; MYO10; NCK1; NEO1; NTN1; NTN4; PAK1; PITPNA; PLCG1; PRKCQ; PTPN11; RGMB; ROBO1; SIAH1; SLIT1; SLIT2; SLIT3; SRC; TRIO; TRPC1; TRPC6; UNC5A; UNC5B; UNC5D"
"R-HSA-380972","Energy dependent regulation of mTOR by LKB1-AMPK",0.098699576708978,0.0842211047140361,0.241233087440255,15,"CAB39; CAB39L; LAMTOR3; LAMTOR4; LAMTOR5; MLST8; MTOR; PPM1A; PRKAA2; PRKAB2; PRKAG2; RPTOR; SLC38A9; STRADB; TSC1"
"R-HSA-70263","Gluconeogenesis",0.151619493414714,0.129751732257251,0.242590865321374,15,"ALDOB; ALDOC; ENO1; ENO3; G6PC3; GOT2; MDH2; PCK2; PGAM1; SLC25A1; SLC25A10; SLC25A12; SLC25A13; SLC37A1; SLC37A2"
"R-HSA-390522","Striated Muscle Contraction",-0.156607962063358,0.134270338928171,0.243467691128988,12,"MYBPC1; MYH3; MYL3; NEB; TCAP; TNNT1; TNNT2; TPM1; TPM2; TPM4; TTN; VIM"
"R-HSA-177929","Signaling by EGFR",0.0334007197408029,0.0289652309798297,0.248856421312955,25,"ADAM10; ADAM17; CBL; EGF; EGFR; EPS15; GAB1; GRB2; KRAS; LRIG1; PAG1; PIK3CA; PIK3R1; PLCG1; PTPN11; PTPN12; PTPRK; PXN; SH3GL2; SPRY2; SRC; STAM; STAM2; UBA52; UBC"
"R-HSA-982772","Growth hormone receptor signaling",0.06647569314635,0.0578976064636352,0.250902680441917,10,"ADAM17; GHR; JAK2; LYN; MAPK1; MAPK3; PRLR; SH2B1; SOCS2; STAT3"
"R-HSA-2173782","Binding and Uptake of Ligands by Scavenger Receptors",0.0875260177438882,0.076486775249072,0.252487314554365,10,"APOB; APOE; CALR; CD36; COLEC12; FTH1; FTL; HPR; HSP90AA1; HSPH1"
"R-HSA-8949215","Mitochondrial calcium ion transport",-0.152726311160226,0.133677335878164,0.25324638613879,12,"AKAP1; LETM1; MCU; MICU1; MICU3; PARL; SLC8A3; SPG7; STOML2; VDAC1; VDAC3; YME1L1"
"R-HSA-68827","CDT1 association with the CDC6:ORC:origin complex",-0.0216412796680586,0.019327733956897,0.262841273123616,28,"MCM8; ORC2; ORC4; ORC5; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; UBA52; UBC"
"R-HSA-5358508","Mismatch Repair",0.0620376766668964,0.0558467120693171,0.266630171724692,12,"EXO1; LIG1; MLH1; MSH2; MSH3; MSH6; PMS2; POLD2; POLD3; RPA1; RPA2; RPA3"
"R-HSA-425410","Metal ion SLC transporters",0.158286740436323,0.142729381340731,0.267430615619312,14,"CP; SLC11A1; SLC30A10; SLC30A3; SLC30A5; SLC30A6; SLC30A7; SLC31A1; SLC39A10; SLC39A3; SLC39A4; SLC39A6; SLC39A8; SLC40A1"
"R-HSA-5683057","MAPK family signaling cascades",-0.0384186414010308,0.03514831579488,0.274374659988956,26,"AGO2; ANGPT1; ARRB1; ARRB2; BTC; CALM1; CAMK2B; CAMK2D; CCND3; CDC14A; CDC14B; CDC42EP2; CDC42EP3; CUL3; DUSP16; DUSP4; DUSP6; DUSP7; EGF; EGFR; ERBB2; ERBB3; ERBB4; FGF1; FGF10; FGF17"
"R-HSA-165054","Rev-mediated nuclear export of HIV RNA",-0.0328151980089728,0.0302136998751346,0.277433309090388,21,"AAAS; NDC1; NUP107; NUP205; NUP214; NUP35; NUP37; NUP43; NUP50; NUP54; NUP62; NUP85; NUP88; NUP93; POM121; POM121C; RAE1; RAN; RANBP2; SEH1L; XPO1"
"R-HSA-168274","Export of Viral Ribonucleoproteins from Nucleus",-0.0328151980089728,0.0302136998751346,0.277433309090388,21,"AAAS; NDC1; NUP107; NUP205; NUP214; NUP35; NUP37; NUP43; NUP50; NUP54; NUP62; NUP85; NUP88; NUP93; POM121; POM121C; RAE1; RAN; RANBP2; SEH1L; XPO1"
"R-HSA-168333","NEP/NS2 Interacts with the Cellular Export Machinery",-0.0328151980089728,0.0302136998751346,0.277433309090388,21,"AAAS; NDC1; NUP107; NUP205; NUP214; NUP35; NUP37; NUP43; NUP50; NUP54; NUP62; NUP85; NUP88; NUP93; POM121; POM121C; RAE1; RAN; RANBP2; SEH1L; XPO1"
"R-HSA-170834","Signaling by TGF-beta Receptor Complex",0.0351710481497842,0.0326398924176768,0.281235555052255,36,"ARHGEF18; BAMBI; CBL; CCNK; CCNT1; CCNT2; CDK8; CDK9; CDKN2B; E2F5; F11R; FKBP1A; FURIN; HDAC1; MTMR4; MYC; NCOR1; NCOR2; PARD6A; PARP1; PMEPA1; PPM1A; PPP1CB; PPP1R15A; RBL1; SKIL; SMAD3; SMAD7; SMURF1; SNW1; TFDP1; TGFB1; TGFBR2; TRIM33; UBA52; UBC"
"R-HSA-2980766","Nuclear Envelope Breakdown",-0.0304453084476794,0.0285420948364023,0.286115938423283,33,"AAAS; BANF1; CNEP1R1; LEMD2; LEMD3; LMNB1; LPIN1; LPIN2; LPIN3; NDC1; NEK6; NUP107; NUP205; NUP214; NUP35; NUP37; NUP43; NUP50; NUP54; NUP62; NUP85; NUP88; NUP93; PLK1; POM121; POM121C; PRKCA; PRKCB; RAE1; RANBP2; SEH1L; TMPO; VRK1"
"R-HSA-2173796","SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription",0.0405767332210742,0.0381377465932926,0.287350427301269,16,"CCNK; CCNT1; CCNT2; CDK8; CDK9; CDKN2B; E2F5; HDAC1; MYC; RBL1; SMAD3; SMAD7; SNW1; TFDP1; UBA52; UBC"
"R-HSA-5610780","Degradation of GLI1 by the proteasome",-0.0201364435838498,0.0190950835903491,0.291637814903324,29,"BTRC; NUMB; PRKACA; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; SKP1; SUFU; UBA52; UBC"
"R-HSA-500657","Presynaptic function of Kainate receptors",0.0535776995982787,0.0509836695606064,0.293313878908703,11,"GNB2; GNB3; GNB4; GNB5; GNG11; GNG4; GNG5; GNG7; GRIK3; PLCB1; PLCB3"
"R-HSA-381038","XBP1(S) activates chaperone genes",0.0770422091882873,0.0744501041077215,0.300754533979092,32,"ACADVL; ADD1; ATP6V0D1; CUL7; DDX11; DNAJB11; DNAJB9; DNAJC3; EXTL2; GOSR2; HDGF; KDELR3; PDIA6; PLA2G4B; PREB; SEC61A2; SEC61B; SEC61G; SEC62; SEC63; SERP1; SRPRB; SSR1; SYVN1; TATDN2; TLN1; TPP1; WFS1; WIPI1; XBP1; YIF1A; ZBTB17"
"R-HSA-6811558","PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling",0.0307519708604157,0.0299461156928736,0.30446276339436,33,"AKT1; BTC; EGF; EGFR; ERBB2; ERBB3; ERBB4; ESR1; ESR2; FGF1; FGF10; FGF17; FGF5; FGF9; FGFR1; FGFR2; FYN; GAB1; GRB2; IL1RAP; IL1RL1; IL33; KIT; KITLG; KL; KLB; MAPK1; MAPK3; MET; NRG2; NRG4; PDGFA; PDGFRA"
"R-HSA-8939902","Regulation of RUNX2 expression and activity",0.021381487480451,0.0208927412449794,0.306122014834643,30,"BMP2; DLX6; ESR1; GSK3B; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; RUNX2; SKP1; SKP2; SMURF1"
"R-HSA-5676590","NIK-->noncanonical NF-kB signaling",-0.0196116603596491,0.0192794531000101,0.309043478013517,27,"BTRC; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; SKP1; UBA3; UBA52; UBC"
"R-HSA-174113","SCF-beta-TrCP mediated degradation of Emi1",-0.0195772648904012,0.0192879031135135,0.310104759111665,26,"BTRC; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; SKP1; UBA52; UBC"
"R-HSA-72187","mRNA 3'-end processing",0.051317128338936,0.0506219798447575,0.310710579944513,32,"CASC3; CDC40; CHTOP; CPSF1; CPSF2; CPSF3; CPSF4; CPSF7; CSTF1; CSTF2T; DDX39B; DHX38; FYTTD1; MAGOHB; NCBP1; NCBP2; PAPOLA; PCF11; RNPS1; SLU7; SRSF4; SRSF7; SRSF9; SYMPK; THOC1; THOC3; THOC5; THOC6; THOC7; U2AF1L4; U2AF2; ZC3H11A"
"R-HSA-168256","Immune System",-0.0319613263875687,0.0315611203931402,0.311212867537566,34,"AAAS; ABCE1; ABI2; ACLY; ACTB; ACTG1; ACTR10; ACTR1B; ACTR2; ADAM10; ADAM17; ADAM8; ADAR; AGA; AGL; AHCYL1; AKT1; AKT2; AKT3; ALAD; ALDOC; ALOX5; AMPD3; ANAPC13; ANAPC4; ANAPC5; ANXA1; ANXA2; AP1B1; AP1M1; AP1S1; AP2A2; AP2B1; AP2M1"
"R-HSA-8979227","Triglyceride metabolism",-0.0739482933510369,0.073180387743176,0.3122589957318,17,"ABHD5; CAV1; DGAT2; FABP3; GK3P; GPAM; GPAT2; GPD2; LPIN1; LPIN2; LPIN3; MGLL; PLIN1; PLIN3; PNPLA5; PPP1CB; PRKACA"
"R-HSA-429958","mRNA decay by 3' to 5' exoribonuclease",-0.0818335916291923,0.0811478499486437,0.31323822930838,11,"DCPS; EXOSC2; EXOSC3; EXOSC4; EXOSC5; EXOSC6; EXOSC8; EXOSC9; HBS1L; NT5C3B; TTC37"
"R-HSA-388396","GPCR downstream signalling",0.0345510525393608,0.0343726055094883,0.314804624229254,35,"ABCA4; ABHD12; ABHD6; ABR; ACKR3; ADCY3; ADCY6; ADCY7; ADCYAP1; ADCYAP1R1; ADM; ADORA2B; ADRA1A; ADRA1B; ADRA2C; ADRB2; AGT; AHCYL1; AKAP13; AKR1C1; AKR1C3; AKT1; AKT2; AKT3; ANXA1; APLNR; APOB; APOE; APP; ARHGEF1; ARHGEF10; ARHGEF10L; ARHGEF11; ARHGEF12; ARHGEF18"
"R-HSA-8939236","RUNX1 regulates transcription of genes involved in differentiation of HSCs",-0.021265932575215,0.021622194766224,0.325349948433969,25,"CDK7; H2AFV; H2AFZ; H3F3A; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; LDB1; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5"
"R-HSA-76066","RNA Polymerase III Transcription Initiation From Type 2 Promoter",-0.0433864836905818,0.0443632300173693,0.328082744292215,13,"BRF1; CRCP; GTF3C2; POLR1C; POLR1D; POLR2E; POLR2H; POLR2K; POLR2L; POLR3E; POLR3G; POLR3H; POLR3K"
"R-HSA-418217","G beta:gamma signalling through PLC beta",0.0499580407030636,0.0511136421862946,0.328375356930564,10,"GNB2; GNB3; GNB4; GNB5; GNG11; GNG4; GNG5; GNG7; PLCB1; PLCB3"
"R-HSA-8963899","Plasma lipoprotein remodeling",0.0849726399302754,0.088228815158367,0.335500367183874,13,"ABCG1; ANGPTL3; ANGPTL4; APOB; APOE; FURIN; GPIHBP1; LIPG; LMF2; MBTPS1; PCSK5; PCSK6; PLTP"
"R-HSA-446193","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein",0.0680374316714787,0.0706588090312328,0.335597251764629,40,"ALG1; ALG10; ALG12; ALG8; CTSA; DHDDS; DPM2; FPGT; GFPT2; GLB1; GNE; GNPNAT1; MPDU1; MPI; MVD; NAGK; NANP; NANS; NEU3; NEU4; NPL; NUDT14; NUS1; PMM1; PMM2; RFT1; SLC17A5; SLC35A1; SLC35C1; SRD5A3; ST3GAL1; ST3GAL2; ST3GAL3; ST3GAL4; ST3GAL5; ST3GAL6; ST6GAL1; ST6GAL2; ST6GALNAC2; ST6GALNAC4"
"R-HSA-1483255","PI Metabolism",0.0490836834958997,0.0511033666299203,0.336814460686742,36,"ARF1; ARF3; ENPP6; FIG4; INPP4B; INPP5D; INPP5E; MTMR2; MTMR3; MTMR4; MTMR6; MTMR7; MTMR9; PI4K2A; PI4K2B; PIK3C2B; PIK3C2G; PIK3C3; PIK3CA; PIK3CB; PIK3CD; PIK3R1; PIK3R5; PIP4K2A; PIP5K1A; PITPNB; PLEKHA1; PLEKHA2; PLEKHA3; PLEKHA5; PLEKHA6; PLEKHA8; PNPLA7; PTEN; PTPN13; RAB14"
"R-HSA-70221","Glycogen breakdown (glycogenolysis)",0.0868798562252992,0.0905545559614924,0.337347180586509,12,"AGL; CALM1; GAA; GYG1; PGM1; PGM2; PGM2L1; PHKB; PHKG1; PYGB; PYGL; PYGM"
"R-HSA-177243","Interactions of Rev with host cellular proteins",-0.0288201431190697,0.0301456210414586,0.339056658520935,22,"AAAS; NDC1; NPM1; NUP107; NUP205; NUP214; NUP35; NUP37; NUP43; NUP50; NUP54; NUP62; NUP85; NUP88; NUP93; POM121; POM121C; RAE1; RAN; RANBP2; SEH1L; XPO1"
"R-HSA-5358565","Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)",0.0534395162507751,0.055976041451403,0.339736754528758,11,"EXO1; LIG1; MLH1; MSH2; MSH6; PMS2; POLD2; POLD3; RPA1; RPA2; RPA3"
"R-HSA-141424","Amplification of signal from the kinetochores",-0.0327049530150063,0.0346333940686618,0.345006940355475,32,"BUB3; CENPC; CENPE; CENPH; CENPL; CENPN; CENPP; CENPQ; CENPT; CKAP5; CLIP1; DSN1; DYNC1H1; DYNC1LI2; DYNLL2; INCENP; ITGB3BP; KIF2A; MAD1L1; MAPRE1; MIS12; NDE1; NDEL1; NSL1; NUDC; NUP107; NUP37; NUP43; NUP85; PAFAH1B1; PLK1; PPP2CA"
"R-HSA-141444","Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal",-0.0327049530150063,0.0346333940686618,0.345006940355475,32,"BUB3; CENPC; CENPE; CENPH; CENPL; CENPN; CENPP; CENPQ; CENPT; CKAP5; CLIP1; DSN1; DYNC1H1; DYNC1LI2; DYNLL2; INCENP; ITGB3BP; KIF2A; MAD1L1; MAPRE1; MIS12; NDE1; NDEL1; NSL1; NUDC; NUP107; NUP37; NUP43; NUP85; PAFAH1B1; PLK1; PPP2CA"
"R-HSA-1226099","Signaling by FGFR in disease",-0.0235280947162213,0.0249755973815635,0.346170460652021,31,"BAG4; BCR; CNTRL; ERLIN2; FGF1; FGF10; FGF17; FGF5; FGF9; FGFR1; FGFR2; GAB1; GRB2; GTF2F2; KRAS; LRRFIP1; NCBP1; NCBP2; PIK3CA; PIK3R1; PLCG1; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L; STAT3; TRIM24"
"R-HSA-450385","Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA",-0.0573427318369741,0.0615985442472015,0.351899860830321,11,"AKT1; DCP1A; DCP2; EXOSC2; EXOSC3; EXOSC4; EXOSC5; EXOSC6; EXOSC8; EXOSC9; ZFP36L1"
"R-HSA-5358606","Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)",0.0519139044329098,0.0559575150239869,0.353543571941279,11,"EXO1; LIG1; MLH1; MSH2; MSH3; PMS2; POLD2; POLD3; RPA1; RPA2; RPA3"
"R-HSA-975576","N-glycan antennae elongation in the medial/trans-Golgi",0.0871488728577498,0.0941148558429048,0.354454172793696,19,"B4GALT2; B4GALT3; B4GALT4; B4GALT5; B4GALT6; CHST10; CHST8; FUT8; MAN2A1; MAN2A2; MGAT2; MGAT3; MGAT4A; MGAT4C; MGAT5; ST3GAL4; ST6GAL1; ST8SIA3; ST8SIA6"
"R-HSA-372790","Signaling by GPCR",0.0313635306005703,0.0344928795432543,0.363204715000239,35,"ABCA4; ABHD12; ABHD6; ABR; ACKR3; ACKR4; ADCY3; ADCY6; ADCY7; ADCYAP1; ADCYAP1R1; ADM; ADORA2B; ADRA1A; ADRA1B; ADRA2C; ADRB2; AGT; AHCYL1; AKAP13; AKR1C1; AKR1C3; AKT1; AKT2; AKT3; ANXA1; APLNR; APOB; APOE; APP; ARHGEF1; ARHGEF10; ARHGEF10L; ARHGEF11; ARHGEF12"
"R-HSA-159236","Transport of Mature mRNA derived from an Intron-Containing Transcript",-0.0250133888524303,0.0275425336680676,0.363786761092229,40,"AAAS; CASC3; CDC40; CHTOP; DDX39B; DHX38; FYTTD1; GLE1; MAGOHB; NCBP1; NCBP2; NDC1; NUP107; NUP205; NUP214; NUP35; NUP37; NUP43; NUP50; NUP54; NUP62; NUP85; NUP88; NUP93; NXF1; POM121; POM121C; RAE1; RANBP2; RNPS1; SEH1L; SLU7; SRSF4; SRSF7; SRSF9; THOC1; THOC3; THOC5; THOC6; THOC7"
"R-HSA-9007101","Rab regulation of trafficking",0.0428842584410623,0.0489363829851023,0.380852460350779,42,"AKT1; AKT2; AKT3; ALS2; ALS2CL; ANKRD27; ARF6; CCZ1; CCZ1B; CHML; DENND1A; DENND1B; DENND2A; DENND2C; DENND3; DENND4A; DENND4B; DENND4C; DENND5A; DENND5B; DENND6A; DENND6B; GDI2; GGA2; HPS1; HPS4; MADD; MAP1LC3B; MON1B; OPTN; POLG; RAB11A; RAB14; RAB1A; RAB21; RAB27A; RAB27B; RAB31; RAB33B; RAB3IL1; RAB3IP; RAB5A"
"R-HSA-71403","Citric acid cycle (TCA cycle)",0.112954223650813,0.129595895036688,0.383433193407759,14,"DLD; DLST; IDH2; IDH3A; IDH3B; MDH2; NNT; SDHA; SDHB; SDHC; SDHD; SUCLA2; SUCLG1; SUCLG2"
"R-HSA-1474244","Extracellular matrix organization",0.0421548887147847,0.0484810082637275,0.384566355088886,41,"A2M; ACAN; ADAM10; ADAM15; ADAM17; ADAM19; ADAM8; ADAM9; ADAMTS1; ADAMTS14; ADAMTS18; ADAMTS2; ADAMTS3; ADAMTS5; ADAMTS8; ADAMTS9; ASPN; BMP1; BMP2; BMP4; BSG; CAPN1; CAPN10; CAPN14; CAPN15; CAPN2; CAPN3; CAPN5; CAPN7; CASP3; CAST; CD151; CD44; CDH1; COL11A2; COL12A1; COL14A1; COL15A1; COL16A1; COL18A1; COL19A1"
"R-HSA-194840","Rho GTPase cycle",0.0545463477882434,0.0628485914679315,0.385448597646018,38,"A2M; ABR; AKAP13; ARAP1; ARAP2; ARAP3; ARHGAP1; ARHGAP11A; ARHGAP12; ARHGAP15; ARHGAP18; ARHGAP19; ARHGAP20; ARHGAP21; ARHGAP22; ARHGAP24; ARHGAP25; ARHGAP26; ARHGAP27; ARHGAP28; ARHGAP29; ARHGAP30; ARHGAP31; ARHGAP32; ARHGAP39; ARHGAP42; ARHGAP9; ARHGEF1; ARHGEF10; ARHGEF10L; ARHGEF11; ARHGEF12; ARHGEF18; ARHGEF3; ARHGEF33; ARHGEF4; ARHGEF40; BCR"
"R-HSA-76061","RNA Polymerase III Transcription Initiation From Type 1 Promoter",-0.0383719090026317,0.0443446686877711,0.386868369872695,14,"BRF1; CRCP; GTF3A; GTF3C2; POLR1C; POLR1D; POLR2E; POLR2H; POLR2K; POLR2L; POLR3E; POLR3G; POLR3H; POLR3K"
"R-HSA-450513","Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA",-0.0684413945685954,0.0794742660759749,0.389140672733045,11,"DCP1A; DCP2; EXOSC2; EXOSC3; EXOSC4; EXOSC5; EXOSC6; EXOSC8; EXOSC9; TNPO1; ZFP36"
"R-HSA-77387","Insulin receptor recycling",-0.0712391873061648,0.0828301145940933,0.389753846670909,12,"ATP6V0A2; ATP6V0B; ATP6V0C; ATP6V0D1; ATP6V0E1; ATP6V0E2; ATP6V1C1; ATP6V1C2; ATP6V1E1; ATP6V1E2; ATP6V1G1; ATP6V1H"
"R-HSA-5654693","FRS-mediated FGFR1 signaling",0.0372157524890938,0.0433466102095903,0.390582208945316,10,"FGF1; FGF10; FGF17; FGF5; FGF9; FGFR1; GRB2; KL; KRAS; PTPN11"
"R-HSA-1296072","Voltage gated Potassium channels",-0.0981745844330036,0.115019221444339,0.393354719631038,19,"KCNA1; KCNA4; KCNAB1; KCNAB3; KCNB1; KCNB2; KCNC1; KCNC2; KCNC4; KCNG1; KCNH5; KCNH7; KCNH8; KCNQ2; KCNQ3; KCNQ5; KCNS1; KCNS2; KCNV2"
"R-HSA-167161","HIV Transcription Initiation",0.0252561590847818,0.0297927909975245,0.396589918494375,25,"CDK7; ERCC2; ERCC3; GTF2A1; GTF2A2; GTF2E1; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L; TAF10; TAF11; TAF12; TAF2; TAF4; TAF4B"
"R-HSA-167162","RNA Polymerase II HIV Promoter Escape",0.0252561590847818,0.0297927909975245,0.396589918494375,25,"CDK7; ERCC2; ERCC3; GTF2A1; GTF2A2; GTF2E1; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L; TAF10; TAF11; TAF12; TAF2; TAF4; TAF4B"
"R-HSA-73776","RNA Polymerase II Promoter Escape",0.0252561590847818,0.0297927909975245,0.396589918494375,25,"CDK7; ERCC2; ERCC3; GTF2A1; GTF2A2; GTF2E1; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L; TAF10; TAF11; TAF12; TAF2; TAF4; TAF4B"
"R-HSA-73779","RNA Polymerase II Transcription Pre-Initiation And Promoter Opening",0.0252561590847818,0.0297927909975245,0.396589918494375,25,"CDK7; ERCC2; ERCC3; GTF2A1; GTF2A2; GTF2E1; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L; TAF10; TAF11; TAF12; TAF2; TAF4; TAF4B"
"R-HSA-75953","RNA Polymerase II Transcription Initiation",0.0252561590847818,0.0297927909975245,0.396589918494375,25,"CDK7; ERCC2; ERCC3; GTF2A1; GTF2A2; GTF2E1; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L; TAF10; TAF11; TAF12; TAF2; TAF4; TAF4B"
"R-HSA-76042","RNA Polymerase II Transcription Initiation And Promoter Clearance",0.0252561590847818,0.0297927909975245,0.396589918494375,25,"CDK7; ERCC2; ERCC3; GTF2A1; GTF2A2; GTF2E1; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L; TAF10; TAF11; TAF12; TAF2; TAF4; TAF4B"
"R-HSA-674695","RNA Polymerase II Pre-transcription Events",-0.0214118699170768,0.0256087895990557,0.40309072016648,38,"AFF4; CCNK; CCNT1; CCNT2; CDK7; CDK9; EAF2; ELL; ERCC2; ERCC3; GTF2A1; GTF2A2; GTF2E1; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; LEO1; MLLT1; NCBP1; NCBP2; NELFA; NELFB; NELFCD; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L; SUPT16H; SUPT5H; TAF10; TAF11; TAF12"
"R-HSA-1483249","Inositol phosphate metabolism",0.0547670210152969,0.0655907888453104,0.403728762015279,24,"CALM1; IMPA1; INPP1; INPP4B; INPP5B; INPP5D; IP6K2; IP6K3; IPMK; IPPK; ISYNA1; ITPKB; MINPP1; MTMR7; MTMR9; NUDT4; PLCB1; PLCB3; PLCD4; PLCE1; PLCG1; PLCG2; PLCH1; PTEN"
"R-HSA-199992","trans-Golgi Network Vesicle Budding",0.0369086997242854,0.0450085513387953,0.412194732233086,42,"ACBD3; AP1B1; AP1M1; AP1S1; AP3B1; AP4B1; AP4E1; AP4S1; APP; ARF1; ARRB1; BLOC1S3; CHMP2A; CLTA; CLVS2; CPD; CTSZ; DNAJC6; DNASE2; DNM2; DTNBP1; FTH1; FTL; GBF1; GOLGB1; HIP1R; HSPA8; M6PR; NAPA; NECAP1; PUM1; RAB5C; SH3D19; SH3GL2; SNAP23; SNAPIN; SNX9; SORT1; STX4; TPD52; TPD52L1; TXNDC5"
"R-HSA-421837","Clathrin derived vesicle budding",0.0369086997242854,0.0450085513387953,0.412194732233086,42,"ACBD3; AP1B1; AP1M1; AP1S1; AP3B1; AP4B1; AP4E1; AP4S1; APP; ARF1; ARRB1; BLOC1S3; CHMP2A; CLTA; CLVS2; CPD; CTSZ; DNAJC6; DNASE2; DNM2; DTNBP1; FTH1; FTL; GBF1; GOLGB1; HIP1R; HSPA8; M6PR; NAPA; NECAP1; PUM1; RAB5C; SH3D19; SH3GL2; SNAP23; SNAPIN; SNX9; SORT1; STX4; TPD52; TPD52L1; TXNDC5"
"R-HSA-163200","Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.",0.0744688512902396,0.0908940375134416,0.412619248998679,23,"ACAD9; COQ10A; COQ10B; COX11; COX14; COX16; COX18; COX20; COX4I1; COX5A; COX6A1; COX6B1; COX6C; COX7A2L; CYCS; ETFB; ETFDH; LRPPRC; NDUFA10; NDUFA11; NDUFA2; NDUFA6; NDUFAB1"
"R-HSA-428930","Thromboxane signalling through TP receptor",0.0421555961810567,0.0518055576133913,0.415801194831276,10,"GNA13; GNA15; GNB2; GNB3; GNB4; GNB5; GNG11; GNG4; GNG5; GNG7"
"R-HSA-6804756","Regulation of TP53 Activity through Phosphorylation",-0.0233131759497819,0.0286761843195278,0.416229292702149,40,"ATM; ATRIP; BARD1; BLM; BRIP1; CCNA1; CCNA2; CDK2; CDK5; CDK5R1; CHEK1; CSNK2A2; DNA2; DYRK2; EXO1; MAPK11; MAPK14; MAPKAPK5; MDM2; MDM4; NBN; PRKAA2; PRKAB2; PRKAG2; RAD1; RAD50; RAD9A; RFC2; RFC3; RFC4; RFC5; RMI1; RMI2; RPA1; RPA2; RPA3; SUPT16H; TAF10; TAF11; TAF12"
"R-HSA-1971475","A tetrasaccharide linker sequence is required for GAG synthesis",-0.071155782147005,0.0877064296867786,0.417196318211693,11,"B3GALT6; B3GAT1; B3GAT2; DCN; GPC5; HSPG2; NCAN; SDC2; SDC3; XYLT1; XYLT2"
"R-HSA-71406","Pyruvate metabolism and Citric Acid (TCA) cycle",0.0653726148153869,0.0806220398382767,0.417450151162797,28,"ADHFE1; BSG; D2HGDH; DLAT; DLD; DLST; GLO1; HAGH; IDH2; IDH3A; IDH3B; LDHB; MDH2; MPC1; MPC2; NNT; PDHB; PDHX; PDK2; RXRA; SDHA; SDHB; SDHC; SDHD; SLC16A1; SUCLA2; SUCLG1; SUCLG2"
"R-HSA-8876198","RAB GEFs exchange GTP for GDP on RABs",0.0393476701273717,0.0491945915849253,0.423805059280114,41,"AKT1; AKT2; AKT3; ALS2; ALS2CL; ANKRD27; CCZ1; CCZ1B; CHML; DENND1A; DENND1B; DENND2A; DENND2C; DENND3; DENND4A; DENND4B; DENND4C; DENND5A; DENND5B; DENND6A; DENND6B; GDI2; HPS1; HPS4; MADD; MON1B; RAB14; RAB1A; RAB21; RAB27A; RAB27B; RAB31; RAB3IL1; RAB3IP; RAB5A; RAB5C; RAB6A; RAB6B; RAB8A; RGP1; RIN1"
"R-HSA-421270","Cell-cell junction organization",-0.0634290963959496,0.0793560294653297,0.42411777888155,23,"CADM3; CDH1; CDH10; CDH13; CDH18; CDH3; CDH4; CDH6; CDH8; CDH9; CLDN1; CLDN11; CLDN12; CLDN15; CLDN16; CTNNA1; F11R; JUP; PARD6A; PARD6B; PARD6G; PVR; SDK1"
"R-HSA-446219","Synthesis of substrates in N-glycan biosythesis",0.0570640280233149,0.0714466259007551,0.424467569632239,39,"CTSA; DHDDS; DPM2; FPGT; GFPT2; GLB1; GNE; GNPNAT1; MPI; MVD; NAGK; NANP; NANS; NEU3; NEU4; NPL; NUDT14; NUS1; PMM1; PMM2; SLC17A5; SLC35A1; SLC35C1; SRD5A3; ST3GAL1; ST3GAL2; ST3GAL3; ST3GAL4; ST3GAL5; ST3GAL6; ST6GAL1; ST6GAL2; ST6GALNAC2; ST6GALNAC4; ST6GALNAC5; ST8SIA1; ST8SIA3; ST8SIA6; TSTA3"
"R-HSA-75067","Processing of Capped Intronless Pre-mRNA",0.0498239402223231,0.0626241337822588,0.426262901133939,15,"CPSF1; CPSF2; CPSF3; CPSF4; CPSF7; CSTF1; CSTF2T; LSM11; NCBP1; NCBP2; PAPOLA; PCF11; SNRPF; SYMPK; ZNF473"
"R-HSA-5655302","Signaling by FGFR1 in disease",0.0290223770920102,0.036497024933927,0.426498082293031,18,"BAG4; BCR; CNTRL; ERLIN2; FGF1; FGF17; FGF5; FGF9; FGFR1; GAB1; GRB2; KRAS; LRRFIP1; PIK3CA; PIK3R1; PLCG1; STAT3; TRIM24"
"R-HSA-4615885","SUMOylation of DNA replication proteins",-0.0240355206246278,0.030361981321865,0.428575193674569,22,"AAAS; INCENP; NDC1; NUP107; NUP205; NUP214; NUP35; NUP37; NUP43; NUP50; NUP54; NUP62; NUP85; NUP88; NUP93; POM121; POM121C; RAE1; RANBP2; SEH1L; TOP1; UBE2I"
"R-HSA-917977","Transferrin endocytosis and recycling",-0.0619238296075431,0.0787876525124785,0.431891767491803,17,"ATP6V0A2; ATP6V0B; ATP6V0C; ATP6V0D1; ATP6V0E1; ATP6V0E2; ATP6V1C1; ATP6V1C2; ATP6V1E1; ATP6V1E2; ATP6V1G1; ATP6V1H; MCOLN1; STEAP2; STEAP3; TF; TFR2"
"R-HSA-909733","Interferon alpha/beta signaling",-0.0526849955891114,0.0671192590933033,0.43248521575966,24,"ABCE1; ADAR; EGR1; HLA-A; HLA-B; HLA-C; HLA-E; IFITM3; IFNAR2; IP6K2; IRF2; IRF5; IRF6; IRF9; JAK1; MX1; MX2; OAS1; OAS2; OAS3; PTPN11; RNASEL; RSAD2; TYK2"
"R-HSA-556833","Metabolism of lipids",0.0478942806242239,0.0615117857099942,0.436203842853532,37,"ABCA1; ABCC1; ABHD4; ABHD5; ACAA2; ACACA; ACACB; ACADL; ACADM; ACADS; ACADVL; ACAT1; ACBD4; ACBD5; ACBD6; ACBD7; ACER2; ACHE; ACLY; ACOT1; ACOT11; ACOT2; ACOT4; ACOT8; ACOX2; ACOX3; ACP6; ACSF2; ACSF3; ACSL1; ACSL5; ACSL6; ACSS3; AGPAT3; AGPAT4; AGPS; AGT"
"R-HSA-180746","Nuclear import of Rev protein",-0.0235780315693039,0.0304086037093005,0.438118871225429,21,"AAAS; NDC1; NPM1; NUP107; NUP205; NUP214; NUP35; NUP37; NUP43; NUP50; NUP54; NUP62; NUP85; NUP88; NUP93; POM121; POM121C; RAE1; RAN; RANBP2; SEH1L"
"R-HSA-70895","Branched-chain amino acid catabolism",-0.0832505996820397,0.108373968096578,0.442380884883517,19,"ACAD8; ACADSB; ACAT1; ALDH6A1; ALDH9A1; AUH; BBOX1; BCAT1; BCKDHA; BCKDHB; DBT; DLD; HIBADH; HIBCH; IVD; MCCC1; MCCC2; PPM1K; SHMT1"
"R-HSA-3296482","Defects in vitamin and cofactor metabolism",-0.0773874281549819,0.102057670611825,0.448288434860763,10,"ACACA; CD320; CUBN; MCCC1; MCCC2; MMAA; MTR; MTRR; PCCB; TCN2"
"R-HSA-8851708","Signaling by FGFR2 IIIa TM",-0.0255958237696694,0.0338093640210074,0.449012027225065,13,"FGF1; FGFR2; GTF2F2; NCBP1; NCBP2; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L"
"R-HSA-3000171","Non-integrin membrane-ECM interactions",-0.0448900806369867,0.0594669261811514,0.450324141418061,23,"DAG1; DDR2; HSPG2; ITGA2; ITGA6; ITGAV; ITGB3; ITGB5; LAMA1; LAMA2; LAMA5; LAMB3; LAMC1; LAMC3; NRXN1; NTN4; PDGFA; PRKCA; SDC2; SDC3; TGFB1; TNC; TRAPPC4"
"R-HSA-191859","snRNP Assembly",-0.0216884422713743,0.0288467612348583,0.452141168666831,30,"AAAS; DDX20; GEMIN5; GEMIN6; GEMIN7; NCBP1; NCBP2; NDC1; NUP107; NUP205; NUP214; NUP35; NUP37; NUP43; NUP50; NUP54; NUP62; NUP85; NUP88; NUP93; PHAX; POM121; POM121C; RAE1; RANBP2; SEH1L; SNRPF; SNUPN; TGS1; WDR77"
"R-HSA-194441","Metabolism of non-coding RNA",-0.0216884422713743,0.0288467612348583,0.452141168666831,30,"AAAS; DDX20; GEMIN5; GEMIN6; GEMIN7; NCBP1; NCBP2; NDC1; NUP107; NUP205; NUP214; NUP35; NUP37; NUP43; NUP50; NUP54; NUP62; NUP85; NUP88; NUP93; PHAX; POM121; POM121C; RAE1; RANBP2; SEH1L; SNRPF; SNUPN; TGS1; WDR77"
"R-HSA-69183","Processive synthesis on the lagging strand",-0.0373385997433337,0.049756708081627,0.452999721594585,10,"DNA2; FEN1; LIG1; POLA2; POLD2; POLD3; PRIM1; RPA1; RPA2; RPA3"
"R-HSA-451326","Activation of kainate receptors upon glutamate binding",0.0342281661791491,0.0458782750418797,0.455628270499715,14,"CALM1; GNB2; GNB3; GNB4; GNB5; GNG11; GNG4; GNG5; GNG7; GRIK1; GRIK3; GRIK4; PLCB1; PLCB3"
"R-HSA-6811440","Retrograde transport at the Trans-Golgi-Network",-0.0555759741830788,0.0747368582095671,0.457105171944592,28,"ARFRP1; ARL1; COG1; COG2; COG3; COG4; COG6; COG7; COG8; GCC1; GCC2; GOLGA1; M6PR; NAA35; NAPA; NAPB; NAPG; NSF; PLIN3; RAB6A; RAB6B; RABEPK; RGP1; RHOBTB3; STX6; SYS1; USP6NL; VAMP4"
"R-HSA-6791226","Major pathway of rRNA processing in the nucleolus and cytosol",0.0404567362884375,0.0544974080143175,0.457868798066901,43,"BMS1; BYSL; C1D; CSNK1D; DCAF13; DDX47; DDX52; DHX37; EBNA1BP2; ERI1; EXOSC10; EXOSC2; EXOSC3; EXOSC4; EXOSC5; EXOSC6; EXOSC8; EXOSC9; FBL; FTSJ3; GNL3; HEATR1; IMP4; ISG20L2; KRR1; LTV1; MPHOSPH10; MPHOSPH6; NOB1; NOL11; NOL6; NOP14; NOP56; NOP58; PDCD11; PELP1; PES1; PNO1; PWP2; RCL1; RIOK2; RPL10A; RPL12"
"R-HSA-1234174","Regulation of Hypoxia-inducible Factor (HIF) by oxygen",-0.0148293448718572,0.0200468042959858,0.459460137481538,32,"AJUBA; ARNT; EGLN1; EGLN2; HIF1A; HIF1AN; HIF3A; HIGD1A; LIMD1; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; UBA52"
"R-HSA-2262749","Cellular response to hypoxia",-0.0148293448718572,0.0200468042959858,0.459460137481538,32,"AJUBA; ARNT; EGLN1; EGLN2; HIF1A; HIF1AN; HIF3A; HIGD1A; LIMD1; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; UBA52"
"R-HSA-3301854","Nuclear Pore Complex (NPC) Disassembly",-0.0226256131450133,0.0307088286002029,0.4612568921074,20,"AAAS; NDC1; NEK6; NUP107; NUP205; NUP214; NUP35; NUP37; NUP43; NUP50; NUP54; NUP62; NUP85; NUP88; NUP93; POM121; POM121C; RAE1; RANBP2; SEH1L"
"R-HSA-3214841","PKMTs methylate histone lysines",-0.0485265703041322,0.0659523396075687,0.461863137609317,22,"AEBP2; ASH1L; ASH2L; DPY30; EHMT1; EZH2; KMT2B; KMT2C; KMT2D; KMT2E; NFKB1; RBBP4; RBBP5; RELA; SETD2; SETD6; SETD7; SETDB2; SMYD2; SMYD3; SUV39H2; WDR5"
"R-HSA-168271","Transport of Ribonucleoproteins into the Host Nucleus",-0.0224169042873688,0.0307702829016137,0.466292590154971,19,"AAAS; NDC1; NUP107; NUP205; NUP214; NUP35; NUP37; NUP43; NUP50; NUP54; NUP62; NUP85; NUP88; NUP93; POM121; POM121C; RAE1; RANBP2; SEH1L"
"R-HSA-170822","Regulation of Glucokinase by Glucokinase Regulatory Protein",-0.0224169042873688,0.0307702829016137,0.466292590154971,19,"AAAS; NDC1; NUP107; NUP205; NUP214; NUP35; NUP37; NUP43; NUP50; NUP54; NUP62; NUP85; NUP88; NUP93; POM121; POM121C; RAE1; RANBP2; SEH1L"
"R-HSA-73980","RNA Polymerase III Transcription Termination",-0.0323415933376896,0.0447810619074775,0.47016177107883,15,"CRCP; NFIA; NFIB; NFIC; NFIX; POLR1C; POLR1D; POLR2E; POLR2H; POLR2K; POLR2L; POLR3E; POLR3G; POLR3H; POLR3K"
"R-HSA-68867","Assembly of the pre-replicative complex",-0.0136772609112436,0.0189690652711396,0.470891194078758,34,"E2F1; MCM2; MCM3; MCM4; MCM6; MCM7; MCM8; ORC2; ORC4; ORC5; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; UBA52; UBC"
"R-HSA-2500257","Resolution of Sister Chromatid Cohesion",0.0277040137002677,0.0385257831551867,0.47207733979212,29,"BUB3; CENPC; CENPE; CENPH; CENPL; CENPN; CENPP; CENPQ; CENPT; CKAP5; CLIP1; DSN1; DYNC1H1; DYNC1LI2; DYNLL2; INCENP; ITGB3BP; KIF2A; MAD1L1; MAPRE1; MIS12; NDE1; NDEL1; NSL1; NUDC; NUP107; NUP37; NUP43; NUP85"
"R-HSA-983168","Antigen processing: Ubiquitination & Proteasome degradation",0.0419140661779214,0.0583547693008217,0.47259519728054,26,"ANAPC13; ANAPC4; ANAPC5; AREL1; ASB1; ASB13; ASB14; ASB2; ASB4; ASB5; ASB6; ATG7; BLMH; BTBD1; BTRC; CDC16; CUL3; CUL5; CUL7; DET1; DTX3L; DZIP3; FBXL14; FBXL15; FBXL20; FBXL4"
"R-HSA-5620924","Intraflagellar transport",0.075140887436363,0.107030119114289,0.482645696544756,26,"CLUAP1; DYNC2H1; DYNC2LI1; DYNLL2; IFT122; IFT27; IFT46; IFT52; IFT57; IFT74; IFT80; IFT88; KIF17; KIF3B; KIFAP3; TCTEX1D1; TCTEX1D2; TNPO1; TRAF3IP1; TRIP11; TTC21B; TTC26; TTC30A; TTC30B; WDR35; WDR60"
"R-HSA-379726","Mitochondrial tRNA aminoacylation",0.0906282580083296,0.129363510562575,0.483571099978661,17,"AARS2; CARS2; DARS2; EARS2; FARS2; GARS; HARS2; KARS; LARS2; NARS2; PARS2; PPA2; QARS; RARS2; TARS2; VARS2; WARS2"
"R-HSA-174143","APC/C-mediated degradation of cell cycle proteins",0.0141191176790954,0.0203903502429141,0.488660328039858,31,"ANAPC16; ANAPC4; ANAPC5; BTRC; BUB3; CCNA1; CCNA2; CDC14A; CDC16; CDK2; NEK2; PLK1; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7"
"R-HSA-453276","Regulation of mitotic cell cycle",0.0141191176790954,0.0203903502429141,0.488660328039858,31,"ANAPC16; ANAPC4; ANAPC5; BTRC; BUB3; CCNA1; CCNA2; CDC14A; CDC16; CDK2; NEK2; PLK1; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7"
"R-HSA-5658442","Regulation of RAS by GAPs",-0.0132481546897535,0.0192581470638683,0.49150021280333,36,"CUL3; KBTBD7; KRAS; NF1; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; RASA1; RASA2; RASA3; RASA4; RASAL1; RASAL2; RASAL3; SPRED2; UBA52; UBC"
"R-HSA-68886","M Phase",-0.0257457726959989,0.0374480636744135,0.491763849905091,31,"AAAS; ALMS1; ANAPC16; ANAPC4; ANAPC5; ANKLE2; ARPP19; BANF1; BLZF1; BUB3; CDC16; CDK5RAP2; CENPC; CENPE; CENPH; CENPJ; CENPL; CENPN; CENPP; CENPQ; CENPT; CEP135; CEP164; CEP192; CEP250; CEP290; CEP41; CEP57; CEP63; CEP72; CEP76"
"R-HSA-381119","Unfolded Protein Response (UPR)",0.039649056954436,0.0576855960812351,0.491874621090916,33,"ACADVL; ADD1; ASNS; ATF3; ATF4; ATF6; ATP6V0D1; CALR; CCL2; CREB3L4; CREBRF; CUL7; DCP2; DDX11; DNAJB11; DNAJB9; DNAJC3; EIF2AK3; EIF2S1; ERN1; EXOSC2; EXOSC3; EXOSC4; EXOSC5; EXOSC6; EXOSC8; EXOSC9; EXTL2; GOSR2; HDGF; HSPA5; KDELR3; MBTPS1"
"R-HSA-450531","Regulation of mRNA stability by proteins that bind AU-rich elements",0.013930908452001,0.0203177046598005,0.492931538519046,40,"AKT1; ANP32A; DCP1A; DCP2; ELAVL1; ENPP2; EXOSC2; EXOSC3; EXOSC4; EXOSC5; EXOSC6; EXOSC8; EXOSC9; HNRNPD; HSPA8; MAPK11; MAPK14; NUP214; PARN; PRKCA; PRKCD; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7"
"R-HSA-182971","EGFR downregulation",0.025872846619739,0.0387225536472485,0.504031709865233,13,"CBL; EGF; EGFR; EPS15; GRB2; PTPN12; PTPRK; SH3GL2; SPRY2; STAM; STAM2; UBA52; UBC"
"R-HSA-450294","MAP kinase activation in TLR cascade",0.0159095395096342,0.0238189983531963,0.504175169263694,40,"ATF1; BTRC; CREB1; DUSP3; DUSP4; DUSP6; DUSP7; IRAK2; JUN; MAP2K6; MAP2K7; MAP3K7; MAP3K8; MAPK1; MAPK10; MAPK11; MAPK14; MAPK3; MAPK8; MEF2A; MEF2C; NFKB1; NOD1; PPP2CA; PPP2R1A; PPP2R1B; PPP2R5D; RPS6KA1; RPS6KA2; RPS6KA5; SKP1; TAB1; TAB2; TNIP2; TRAF6; UBA52; UBC; UBE2N; UBE2V1; VRK3"
"R-HSA-913709","O-linked glycosylation of mucins",-0.0504705670726563,0.0758822909357542,0.505975954005341,29,"B3GNTL1; B4GALT5; B4GALT6; C1GALT1; GALNT1; GALNT10; GALNT13; GALNT14; GALNT15; GALNT16; GALNT18; GALNT2; GALNT3; GALNT6; GALNT7; GALNT9; GALNTL5; GALNTL6; GCNT1; GCNT4; MUC12; MUC20; ST3GAL1; ST3GAL2; ST3GAL3; ST3GAL4; ST6GAL1; ST6GALNAC2; ST6GALNAC4"
"R-HSA-499943","Interconversion of nucleotide di- and triphosphates",-0.0820365010513606,0.124164330750574,0.508798898015563,19,"AK5; AK7; AK8; AK9; CMPK1; CTPS1; DCTD; DTYMK; DUT; GLRX; GUK1; NME1; NME6; NME7; NUDT13; RRM1; TXN; TXNRD1; TYMS"
"R-HSA-1660661","Sphingolipid de novo biosynthesis",0.0814851700414505,0.123963683704185,0.510968118788155,26,"ACER2; ALDH3A2; CERS4; CERS5; CERS6; DEGS1; KDSR; ORMDL1; ORMDL2; ORMDL3; OSBP; PPM1L; PRKD1; PRKD2; PRKD3; SAMD8; SGMS2; SGPL1; SGPP1; SGPP2; SPHK1; SPTLC1; SPTLC2; SPTSSA; VAPA; VAPB"
"R-HSA-196071","Metabolism of steroid hormones",0.0955702879616694,0.146268123875229,0.513504185558964,11,"FDX1; FDXR; HSD17B1; HSD17B11; HSD17B12; HSD17B14; POMC; SRD5A1; SRD5A3; STAR; STARD4"
"R-HSA-8951664","Neddylation",0.0405267792762476,0.0626398946248511,0.517644678364791,35,"ASB1; ASB13; ASB14; ASB2; ASB4; ASB5; ASB6; BTBD1; BTRC; CAND1; CCDC8; COMMD1; COMMD10; COMMD2; COMMD4; COMMD5; COMMD7; COPS2; COPS3; COPS6; COPS7A; CUL3; CUL4A; CUL5; CUL7; CUL9; DCAF11; DCAF13; DCAF16; DCAF17; DCAF4; DCAF7; DCAF8; DCUN1D2; DCUN1D3"
"R-HSA-6791312","TP53 Regulates Transcription of Cell Cycle Genes",0.0274999785799142,0.0427067049051504,0.519623103345321,25,"ARID3A; CARM1; CCNA1; CCNA2; CDK2; CDKN1A; CDKN1B; CENPJ; CNOT11; CNOT2; CNOT4; CNOT6L; CNOT7; CNOT8; E2F1; GADD45A; NPM1; PCBP4; PLAGL1; PRMT1; RBL1; RBL2; TFDP1; TNKS1BP1; TP53"
"R-HSA-5578749","Transcriptional regulation by small RNAs",0.0140710060899694,0.0219399766026431,0.521301169817227,36,"AAAS; AGO2; H2AFV; H2AFZ; H3F3A; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; IPO8; NDC1; NUP107; NUP205; NUP214; NUP35; NUP37; NUP43; NUP50; NUP54; NUP62; NUP85; NUP88; NUP93; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L; POM121"
"R-HSA-179419","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint",0.0124942270920753,0.019522966044308,0.522188289912611,31,"ANAPC16; ANAPC4; ANAPC5; BUB3; CCNA1; CCNA2; CDC16; NEK2; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; UBA52"
"R-HSA-2022870","Chondroitin sulfate biosynthesis",0.078980733741221,0.123924152306953,0.523909105772105,10,"CHPF; CHST11; CHST12; CHST3; CHST9; CHSY3; CSGALNACT1; CSGALNACT2; DCN; NCAN"
"R-HSA-75105","Fatty acyl-CoA biosynthesis",0.0634832763746654,0.100996249427613,0.529630191651615,21,"ACACA; ACLY; ACSF3; ACSL1; ACSL5; ACSL6; CBR4; ELOVL1; ELOVL2; ELOVL4; ELOVL5; ELOVL7; FASN; HSD17B12; HSD17B8; MORC2; RPP14; SCD; SCD5; SLC25A1; TECR"
"R-HSA-3371571","HSF1-dependent transactivation",-0.0375471197844963,0.0599380888799898,0.531031813036509,15,"CAMK2B; CAMK2D; HSBP1; HSF1; HSP90AA1; HSP90AB1; HSPA2; HSPA6; HSPA8; HSPB8; HSPH1; MLST8; MRPL18; MTOR; RPTOR"
"R-HSA-2453902","The canonical retinoid cycle in rods (twilight vision)",0.0837081837151514,0.133688917277407,0.531222111792912,13,"ABCA4; CYP4V2; HSD17B1; HSD17B6; LRAT; MYO7A; RBP1; RBP4; RDH10; RDH11; RDH12; RLBP1; RPE65"
"R-HSA-445355","Smooth Muscle Contraction",-0.0365548314204892,0.0589551916348265,0.535228611679693,21,"ACTA2; ANXA1; ANXA2; ANXA6; CALM1; ITGA1; ITGB5; LMOD1; MYH11; MYL12A; MYL5; MYLK; PAK1; PAK2; PXN; SORBS3; TLN1; TPM1; TPM2; TPM4; VCL"
"R-HSA-211945","Phase I - Functionalization of compounds",0.0565624763297343,0.0916032169223569,0.536923050012258,21,"ACSS1; ACSS2; ADH5; ALDH1A1; ALDH2; ARNT; ARNT2; BPHL; CBR3; CES3; CMBL; CYB5R3; CYP1B1; CYP26A1; CYP26B1; CYP2C8; CYP2E1; CYP2J2; CYP2R1; CYP2U1; CYP39A1"
"R-HSA-2187338","Visual phototransduction",-0.0326001369547932,0.052923886617807,0.537906706244928,23,"ABCA4; AKR1C1; AKR1C3; APOB; APOE; BCO2; CALM1; CAMKMT; CYP4V2; DHRS3; GNB5; GPC5; GPIHBP1; HSD17B1; HSD17B6; HSPG2; LRAT; LRP12; LRP2; LRP8; MYO7A; NMT1; NMT2"
"R-HSA-171306","Packaging Of Telomere Ends",0.0232550590638137,0.0380368060997471,0.540946011925128,14,"ACD; H2AFV; H2AFZ; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; POT1; TERF1; TINF2"
"R-HSA-73780","RNA Polymerase III Chain Elongation",-0.0278799368157905,0.0457225857030269,0.542018875678825,11,"CRCP; POLR1C; POLR1D; POLR2E; POLR2H; POLR2K; POLR2L; POLR3E; POLR3G; POLR3H; POLR3K"
"R-HSA-448424","Interleukin-17 signaling",0.0146253034351932,0.0239937377648548,0.54216213493311,40,"ATF1; BTRC; CREB1; DUSP3; DUSP4; DUSP6; DUSP7; IL17RA; IL17RB; IL17RC; IRAK2; JUN; MAP2K6; MAP2K7; MAP3K7; MAP3K8; MAPK1; MAPK10; MAPK11; MAPK14; MAPK3; MAPK8; MEF2A; MEF2C; NFKB1; NOD1; PPP2CA; PPP2R1A; PPP2R1B; PPP2R5D; RPS6KA1; RPS6KA2; RPS6KA5; SKP1; TAB1; TAB2; TNIP2; TRAF6; UBA52; UBC"
"R-HSA-425366","Transport of bile salts and organic acids, metal ions and amine compounds",0.0595274496088084,0.0983445841849006,0.544983242689547,29,"BSG; CP; EMB; RUNX1; SLC11A1; SLC13A3; SLC13A4; SLC14A1; SLC16A1; SLC18A2; SLC22A15; SLC22A18; SLC22A3; SLC22A5; SLC2A13; SLC30A10; SLC30A3; SLC30A5; SLC30A6; SLC30A7; SLC31A1; SLC39A10; SLC39A3; SLC39A4; SLC39A6; SLC39A8; SLC40A1; SLC44A3; SLC44A5"
"R-HSA-2559586","DNA Damage/Telomere Stress Induced Senescence",-0.0170332866584987,0.0282479712875252,0.54651434195012,33,"ACD; ASF1A; ATM; CABIN1; CCNA1; CCNA2; CDK2; CDKN1A; CDKN1B; EP400; H1F0; H2AFV; H2AFZ; HIST1H1A; HIST1H1C; HIST1H1D; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; HMGA1; LMNB1; NBN; POT1; RAD50; RB1; TERF1; TINF2; TP53"
"R-HSA-3238698","WNT ligand biogenesis and trafficking",-0.116202646540416,0.194503377591604,0.550218635192172,11,"TMED5; VPS29; WLS; WNT10B; WNT16; WNT2; WNT2B; WNT3; WNT5A; WNT7A; WNT7B"
"R-HSA-210500","Glutamate Neurotransmitter Release Cycle",-0.0651784729807294,0.110086270462192,0.553805571184149,11,"ARL6IP5; CPLX1; PPFIA1; PPFIA2; PPFIA4; SLC1A1; SLC1A3; SLC1A6; SLC38A2; SYT1; VAMP2"
"R-HSA-1660662","Glycosphingolipid metabolism",0.0585009480578581,0.0989512307056834,0.554379784513592,21,"ARSA; ARSB; ASAH1; ASAH2; B4GALNT1; CTSA; ESYT1; ESYT2; ESYT3; GALC; GBA2; GLB1; GM2A; HEXA; HEXB; NEU3; NEU4; PSAP; SMPD2; SUMF1; SUMF2"
"R-HSA-6799198","Complex I biogenesis",-0.063423415025469,0.107419397918095,0.554903775992024,30,"ACAD9; NDUFA10; NDUFA11; NDUFA2; NDUFA6; NDUFAB1; NDUFAF1; NDUFAF2; NDUFAF4; NDUFAF5; NDUFAF6; NDUFAF7; NDUFB10; NDUFB4; NDUFB5; NDUFB7; NDUFC1; NDUFS1; NDUFS2; NDUFS4; NDUFS5; NDUFS6; NDUFS7; NDUFS8; NDUFV1; NDUFV2; NDUFV3; NUBPL; TIMMDC1; TMEM126B"
"R-HSA-1638074","Keratan sulfate/keratin metabolism",-0.0429995096102015,0.0729454438313301,0.555542732039214,18,"ACAN; B4GALT2; B4GALT3; B4GALT4; B4GALT5; B4GALT6; CHST1; CHST6; FMOD; GLB1; HEXA; HEXB; LUM; ST3GAL1; ST3GAL2; ST3GAL3; ST3GAL4; ST3GAL6"
"R-HSA-6788656","Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism",0.0750978112096247,0.129120557561899,0.560829386169485,20,"AADAT; AASS; ALDH4A1; ALDH7A1; AMDHD1; ASRGL1; DLD; DLST; FAH; FTCD; GCDH; GSTZ1; HYKK; PAH; PCBD1; PHYKPL; PIPOX; PRODH; SLC36A4; TDO2"
"R-HSA-196854","Metabolism of vitamins and cofactors",-0.0266444981344682,0.0458354451758289,0.561033078431732,32,"ABCC1; ABCD4; ACACA; ACACB; AKR1C1; AKR1C3; AKT1; ALDH1L2; AOX1; APOB; APOE; BCO2; CALM1; CD320; CD38; COASY; COQ5; COQ7; COQ9; CUBN; CYB5A; CYB5R3; DHFR; ENPP1; ENPP2; FASN; GCH1; GPC5; GPHN; GPIHBP1; GSTO1; GSTO2"
"R-HSA-72086","mRNA Capping",0.0165105424947984,0.0293598179433597,0.573876444261976,20,"CDK7; ERCC2; ERCC3; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; NCBP1; NCBP2; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L; RNGTT; SUPT5H"
"R-HSA-174184","Cdc20:Phospho-APC/C mediated degradation of Cyclin A",0.0108950626368184,0.0195642553683416,0.57760522543915,30,"ANAPC16; ANAPC4; ANAPC5; BUB3; CCNA1; CCNA2; CDC16; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; UBA52"
"R-HSA-168253","Host Interactions with Influenza Factors",0.0165352077493188,0.030621334210927,0.589204075453224,24,"AAAS; CPSF4; KPNA3; KPNA4; KPNA5; NDC1; NUP107; NUP205; NUP214; NUP35; NUP37; NUP43; NUP50; NUP54; NUP62; NUP85; NUP88; NUP93; POM121; POM121C; RAE1; RANBP2; SEH1L; TGFB1"
"R-HSA-163359","Glucagon signaling in metabolic regulation",-0.0223720816806118,0.042261128355736,0.596543747627674,14,"ADCY3; ADCY6; ADCY7; GNB2; GNB3; GNB4; GNG11; GNG4; GNG5; GNG7; PRKACA; PRKAR1A; PRKAR1B; PRKAR2A"
"R-HSA-611105","Respiratory electron transport",0.0430431407362854,0.0819911390137322,0.599601905329558,33,"ACAD9; COQ10A; COQ10B; COX11; COX14; COX16; COX18; COX20; COX4I1; COX5A; COX6A1; COX6B1; COX6C; COX7A2L; CYCS; ETFB; ETFDH; LRPPRC; NDUFA10; NDUFA11; NDUFA2; NDUFA6; NDUFAB1; NDUFAF1; NDUFAF2; NDUFAF4; NDUFAF5; NDUFAF6; NDUFAF7; NDUFB10; NDUFB4; NDUFB5; NDUFB7"
"R-HSA-382556","ABC-family proteins mediated transport",-0.014819208844973,0.028521351099447,0.603354257257965,33,"ABCA10; ABCA4; ABCA5; ABCA6; ABCA7; ABCA8; ABCA9; ABCB10; ABCB8; ABCB9; ABCC1; ABCC10; ABCC4; ABCC5; ABCC8; ABCC9; ABCG1; CFTR; DERL1; EIF2S1; ERLEC1; ERLIN2; KCNJ11; PEX3; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6"
"R-HSA-1483206","Glycerophospholipid biosynthesis",0.0361663820946946,0.0699264466705922,0.605012320954593,39,"ABHD4; ACHE; ACP6; AGPAT3; AGPAT4; BCHE; CDS1; CDS2; CEPT1; CHKA; CHKB; CHPT1; CPNE1; CPNE3; CPNE6; CPNE7; CRLS1; CSNK2A2; DDHD1; DDHD2; DGAT2; ETNK1; GPAM; GPAT2; GPCPD1; GPD1L; GPD2; HADHA; HADHB; LCLAT1; LPCAT1; LPCAT2; LPCAT3; LPGAT1; LPIN1; LPIN2; LPIN3; MBOAT1; MGLL"
"R-HSA-156581","Methylation",-0.0625396432718389,0.121299565601158,0.606147705636362,10,"AHCY; AS3MT; COMT; GSTO1; MAT2A; MTR; MTRR; N6AMT1; TPMT; TRMT112"
"R-HSA-112310","Neurotransmitter release cycle",0.0435728622154015,0.0846538554651143,0.606750101261338,24,"ABAT; ALDH5A1; ARL6IP5; CPLX1; DNAJC5; GAD1; GAD2; HSPA8; LIN7A; LIN7B; LIN7C; NAAA; PPFIA1; PPFIA2; PPFIA4; SLC18A2; SLC1A1; SLC1A3; SLC1A6; SLC38A2; SLC6A13; SYN3; SYT1; VAMP2"
"R-HSA-432040","Vasopressin regulates renal water homeostasis via Aquaporins",0.021187007039012,0.0413244792977215,0.608162095394356,17,"ADCY3; ADCY6; ADCY7; GNB2; GNB3; GNB4; GNB5; GNG11; GNG4; GNG5; GNG7; MYO5B; PRKACA; PRKAR1A; PRKAR1B; PRKAR2A; RAB11A"
"R-HSA-450604","KSRP (KHSRP) binds and destabilizes mRNA",-0.0266455535185854,0.0521894703191909,0.609663249788208,13,"AKT1; DCP2; EXOSC2; EXOSC3; EXOSC4; EXOSC5; EXOSC6; EXOSC8; EXOSC9; MAPK11; MAPK14; PARN; YWHAZ"
"R-HSA-3214842","HDMs demethylate histones",0.107786113771322,0.212968287109985,0.612777011554774,10,"ARID5B; KDM1B; KDM2A; KDM2B; KDM3A; KDM4C; KDM5B; KDM6B; KDM8; PHF2"
"R-HSA-1296065","Inwardly rectifying K+ channels",0.0293817762677062,0.058141402023003,0.613312803865418,13,"ABCC8; ABCC9; GNB2; GNB3; GNG4; GNG5; GNG7; KCNJ11; KCNJ14; KCNJ16; KCNJ3; KCNJ4; KCNJ8"
"R-HSA-5617472","Activation of anterior HOX genes in hindbrain development during early embryogenesis",-0.0157210218423307,0.0312804791552719,0.61525782596349,28,"AJUBA; ASH2L; CTCF; EZH2; H2AFV; H2AFZ; H3F3A; HDAC3; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; JUN; KMT2C; KMT2D; MEIS1; NCOA3; NCOA6; NCOR1; PAX6; PBX1; PIAS2; PKNOX1; POLR2A"
"R-HSA-5619507","Activation of HOX genes during differentiation",-0.0157210218423307,0.0312804791552719,0.61525782596349,28,"AJUBA; ASH2L; CTCF; EZH2; H2AFV; H2AFZ; H3F3A; HDAC3; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; JUN; KMT2C; KMT2D; MEIS1; NCOA3; NCOA6; NCOR1; PAX6; PBX1; PIAS2; PKNOX1; POLR2A"
"R-HSA-6784531","tRNA processing in the nucleus",0.0151373738225014,0.0303558462540222,0.618015968264512,33,"AAAS; C2orf49; CPSF1; CPSF4; ELAC2; NDC1; NUP107; NUP205; NUP214; NUP35; NUP37; NUP43; NUP50; NUP54; NUP62; NUP85; NUP88; NUP93; POM121; POM121C; POP4; POP5; POP7; RAE1; RAN; RANBP2; RPP14; RPP30; RPP38; SEH1L; TRNT1; TSEN15; ZBTB8OS"
"R-HSA-445717","Aquaporin-mediated transport",0.0204663378413151,0.0412679239454666,0.619938049183199,18,"ADCY3; ADCY6; ADCY7; AQP11; GNB2; GNB3; GNB4; GNB5; GNG11; GNG4; GNG5; GNG7; MYO5B; PRKACA; PRKAR1A; PRKAR1B; PRKAR2A; RAB11A"
"R-HSA-389661","Glyoxylate metabolism and glycine degradation",0.055695675198092,0.112702354946967,0.621176397446388,19,"ALDH4A1; BCKDHA; BCKDHB; DBT; DDO; DLAT; DLD; DLST; GCSH; GLDC; GOT2; GRHPR; HOGA1; LIAS; LIPT1; NDUFAB1; PDHB; PDHX; PXMP2"
"R-HSA-5621575","CD209 (DC-SIGN) signaling",-0.0249874570954699,0.0512109394832565,0.625597993997865,10,"FYN; ICAM3; KRAS; LYN; NFKB1; PAK1; PAK2; PRKACA; RELA; RPS6KA5"
"R-HSA-4570464","SUMOylation of RNA binding proteins",-0.0145168831679925,0.0300204353859824,0.628693405400127,25,"AAAS; CBX4; HNRNPK; NDC1; NOP58; NUP107; NUP205; NUP214; NUP35; NUP37; NUP43; NUP50; NUP54; NUP62; NUP85; NUP88; NUP93; PHC2; POM121; POM121C; RAE1; RANBP2; RNF2; SEH1L; UBE2I"
"R-HSA-3371497","HSP90 chaperone cycle for steroid hormone receptors (SHR)",0.0279757190941911,0.0582433830766558,0.630996728503136,16,"ACTR10; CAPZA2; CAPZB; DCTN3; DCTN5; DCTN6; DNAJA1; DNAJA4; DYNC1H1; DYNC1LI2; DYNLL2; FKBP5; HSP90AA1; HSP90AB1; HSPA2; HSPA8"
"R-HSA-373080","Class B/2 (Secretin family receptors)",0.0222278961893907,0.0464583411881238,0.632331441591235,27,"ADCYAP1; ADCYAP1R1; ADM; CALCRL; CD55; CRH; CRHR1; CRHR2; FZD1; FZD3; FZD6; FZD8; GLP2R; GNB2; GNB3; GNB4; GNB5; GNG11; GNG4; GNG5; GNG7; PTCH1; PTCH2; PTH1R; PTH2R; PTHLH; RAMP3"
"R-HSA-163125","Post-translational modification: synthesis of GPI-anchored proteins",-0.0537390438151717,0.114187298684696,0.637910763459541,28,"ALPL; ART3; CD109; CNTN4; CNTN5; CPM; DPM2; FCGR3B; GPAA1; GPIHBP1; LY6H; LYPD1; LYPD5; LYPD6B; MDGA1; NTM; NTNG1; PIGB; PIGC; PIGF; PIGG; PIGH; PIGK; PIGM; PIGN; PIGP; PIGS; PIGV"
"R-HSA-199220","Vitamin B5 (pantothenate) metabolism",-0.0698556266481317,0.150060826118395,0.641562405728138,13,"COASY; ENPP1; ENPP2; FASN; PANK1; PANK2; PANK3; PANK4; PPCDC; PPCS; SLC25A16; SLC5A6; VNN2"
"R-HSA-8953897","Cellular responses to external stimuli",0.0180663665580356,0.0394530680108184,0.647009596004958,31,"AAAS; ACD; ACTR10; AJUBA; AMBRA1; ANAPC16; ANAPC4; ANAPC5; ARNT; ASF1A; ATG10; ATG12; ATG13; ATG14; ATG3; ATG4C; ATG7; ATG9A; ATM; BAG2; BAG4; BAG5; CABIN1; CAMK2B; CAMK2D; CAPZA2; CAPZB; CAT; CBX4; CCNA1; CCNA2"
"R-HSA-5694530","Cargo concentration in the ER",0.0431189869424291,0.0967764515931149,0.655920550994507,18,"CD59; CNIH3; CTSC; CTSZ; F5; GOSR2; GRIA1; LMAN1; MCFD2; MIA3; PREB; SAR1B; SEC23A; SEC24C; SERPINA1; TGFA; TMED10; TMED2"
"R-HSA-167160","RNA Pol II CTD phosphorylation and interaction with CE during HIV infection",0.0136652036704986,0.0307121685688684,0.656360023172366,18,"CDK7; ERCC2; ERCC3; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L; RNGTT; SUPT5H"
"R-HSA-77075","RNA Pol II CTD phosphorylation and interaction with CE",0.0136652036704986,0.0307121685688684,0.656360023172366,18,"CDK7; ERCC2; ERCC3; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L; RNGTT; SUPT5H"
"R-HSA-109688","Cleavage of Growing Transcript in the Termination Region ",0.0217907028943196,0.0492274365002273,0.658016295538978,35,"CASC3; CDC40; CHTOP; CPSF1; CPSF2; CPSF3; CPSF4; CPSF7; CSTF1; CSTF2T; DDX39B; DHX38; FYTTD1; LSM11; MAGOHB; NCBP1; NCBP2; PAPOLA; PCF11; RNPS1; SLU7; SNRPF; SRSF4; SRSF7; SRSF9; SYMPK; THOC1; THOC3; THOC5; THOC6; THOC7; U2AF1L4; U2AF2; ZC3H11A; ZNF473"
"R-HSA-73856","RNA Polymerase II Transcription Termination",0.0217907028943196,0.0492274365002273,0.658016295538978,35,"CASC3; CDC40; CHTOP; CPSF1; CPSF2; CPSF3; CPSF4; CPSF7; CSTF1; CSTF2T; DDX39B; DHX38; FYTTD1; LSM11; MAGOHB; NCBP1; NCBP2; PAPOLA; PCF11; RNPS1; SLU7; SNRPF; SRSF4; SRSF7; SRSF9; SYMPK; THOC1; THOC3; THOC5; THOC6; THOC7; U2AF1L4; U2AF2; ZC3H11A; ZNF473"
"R-HSA-3000157","Laminin interactions",0.0374430617096165,0.0849149536460082,0.65925079011224,14,"COL18A1; HSPG2; ITGA1; ITGA2; ITGA3; ITGA6; ITGAV; LAMA1; LAMA2; LAMA5; LAMB3; LAMC1; LAMC3; NID1"
"R-HSA-2028269","Signaling by Hippo",0.0536344974943653,0.122184833988699,0.660689080413655,10,"CASP3; DVL2; LATS1; MOB1B; NPHP4; SAV1; STK4; TJP1; TJP2; YWHAE"
"R-HSA-913531","Interferon Signaling",0.0238899566355091,0.0544272051414814,0.66070928296822,22,"AAAS; ABCE1; ADAR; CAMK2B; CAMK2D; CD44; CIITA; DDX58; EGR1; EIF4A1; EIF4A2; EIF4E; EIF4E3; FLNB; GBP3; HERC5; HLA-A; HLA-B; HLA-C; HLA-E; ICAM1; IFITM3"
"R-HSA-425397","Transport of vitamins, nucleosides, and related molecules",0.0706132528488176,0.162449599662378,0.663796232989592,20,"LCN12; LCN15; SLC27A1; SLC27A4; SLC27A6; SLC29A1; SLC29A3; SLC29A4; SLC33A1; SLC35A1; SLC35B3; SLC35B4; SLC35C1; SLC5A6; SLCO1A2; SLCO1C1; SLCO2A1; SLCO3A1; SLCO4A1; SLCO4C1"
"R-HSA-418990","Adherens junctions interactions",-0.0414492258841912,0.0976497730945727,0.671224373657013,13,"CADM3; CDH1; CDH10; CDH13; CDH18; CDH3; CDH4; CDH6; CDH8; CDH9; CTNNA1; JUP; PVR"
"R-HSA-1169091","Activation of NF-kappaB in B cells",-0.00780267807314439,0.0187175961300099,0.676778430790478,36,"BTRC; CARD11; MALT1; MAP3K7; NFKB1; NFKBIA; NFKBIB; NFKBIE; PRKCB; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; REL; RELA; SKP1; UBA52; UBC"
"R-HSA-5632684","Hedgehog 'on' state",0.00884100437707604,0.0212434225176986,0.677281159443736,35,"ARRB1; ARRB2; BOC; CDON; CUL3; DZIP1; EFCAB7; EVC2; GAS1; GAS8; GPR161; HHIP; IQCE; KIF7; NUMB; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2"
"R-HSA-2219530","Constitutive Signaling by Aberrant PI3K in Cancer",0.0119809504880955,0.029289639060004,0.682502376272352,33,"BTC; EGF; EGFR; ERBB2; ERBB3; ERBB4; ESR1; ESR2; FGF1; FGF10; FGF17; FGF5; FGF9; FGFR1; FGFR2; FYN; GAB1; GRB2; KIT; KITLG; KL; KLB; MET; NRG2; NRG4; PDGFA; PDGFRA; PIK3CA; PIK3CB; PIK3CD; PIK3R1; PTPN11; SRC"
"R-HSA-416572","Sema4D induced cell migration and growth-cone collapse",-0.0293490349406642,0.0742452962261881,0.692622798005894,15,"ARHGEF11; ARHGEF12; ERBB2; LIMK1; LIMK2; MYH10; MYH11; MYH14; MYH9; PLXNB1; RHOB; RND1; ROCK1; ROCK2; SEMA4D"
"R-HSA-2022854","Keratan sulfate biosynthesis",-0.0311241589778566,0.080287276966867,0.698267723485611,15,"ACAN; B4GALT2; B4GALT3; B4GALT4; B4GALT5; B4GALT6; CHST1; CHST6; FMOD; LUM; ST3GAL1; ST3GAL2; ST3GAL3; ST3GAL4; ST3GAL6"
"R-HSA-114452","Activation of BH3-only proteins",0.0166095580002911,0.0429408382552311,0.698903557153312,20,"AKT1; AKT2; AKT3; BCL2; BCL2L11; BID; BMF; DYNLL2; E2F1; MAPK8; PPP1R13B; PPP3CC; PPP3R1; TFDP1; TP53; TP53BP2; YWHAE; YWHAG; YWHAQ; YWHAZ"
"R-HSA-8955332","Carboxyterminal post-translational modifications of tubulin",-0.0441165383288314,0.114488838626379,0.699989352004101,18,"AGBL3; AGTPBP1; NICN1; TPGS2; TTLL1; TTLL11; TTLL12; TTLL3; TTLL5; TTLL6; TTLL7; TTLL9; TUBA1A; TUBA1C; TUBB2A; TUBB2B; TUBB3; TUBB6"
"R-HSA-1222556","ROS, RNS production in phagocytes",-0.0300425430981025,0.079289818733707,0.704765582270164,16,"ATP6V0A2; ATP6V0B; ATP6V0C; ATP6V0D1; ATP6V0E1; ATP6V0E2; ATP6V1C1; ATP6V1C2; ATP6V1E1; ATP6V1E2; ATP6V1G1; ATP6V1H; NOS1; NOS2; NOS3; SLC11A1"
"R-HSA-168643","Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways",0.0157471503481967,0.0418877655510529,0.706963920323678,28,"APP; BCL2; BIRC2; CASP4; CASP8; CASP9; CYLD; HSP90AB1; IRAK2; MAP2K6; MAP3K7; MAPK11; MAPK12; MAPK13; MAPK14; NLRC4; NLRP1; NLRP3; NOD1; P2RX7; PANX1; TAB1; TAB2; TNFAIP3; TRAF6; TXN; UBE2N; UBE2V1"
"R-HSA-2672351","Stimuli-sensing channels",0.0284159027682024,0.0764374758758649,0.710076352978401,31,"ANO10; ANO2; ANO3; ANO5; ASIC1; ASIC2; ASPH; BEST1; BEST3; CALM1; CLCA4; CLCN2; CLCN3; CLCN6; FKBP1B; MCOLN1; NALCN; OSTM1; RYR1; RYR2; RYR3; SCNN1D; SLC9B1; SLC9B2; SLC9C2; SRI; STOM; TPCN2; TRDN; TRPA1; TRPC1"
"R-HSA-5693554","Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)",-0.0184858866536004,0.0503002551462056,0.713238042657283,17,"ATM; BARD1; BLM; BRCA2; BRIP1; DNA2; EXO1; NBN; PALB2; RAD50; RAD51B; RAD51C; RMI1; RMI2; TOP3A; WRN; XRCC2"
"R-HSA-3000170","Syndecan interactions",0.0284373753138755,0.079237492469468,0.719678970364695,11,"ITGA2; ITGA6; ITGAV; ITGB3; ITGB5; PRKCA; SDC2; SDC3; TGFB1; TNC; TRAPPC4"
"R-HSA-5607761","Dectin-1 mediated noncanonical NF-kB signaling",-0.00679127537434574,0.0193111698884788,0.725081246186559,28,"BTRC; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; RELA; SKP1; UBA3; UBA52; UBC"
"R-HSA-109606","Intrinsic Pathway for Apoptosis",-0.0135025841858665,0.0390950663650038,0.729810053599277,27,"AKT1; AKT2; AKT3; BAK1; BCL2; BCL2L11; BID; BMF; CASP3; CASP7; CASP8; CASP9; CYCS; DYNLL2; E2F1; MAPK8; NMT1; PPP1R13B; PPP3CC; PPP3R1; TFDP1; TP53; TP53BP2; YWHAE; YWHAG; YWHAQ; YWHAZ"
"R-HSA-74158","RNA Polymerase III Transcription",-0.0146013651719404,0.0426051687405555,0.731814029010559,25,"BRF1; CRCP; GTF3A; GTF3C2; NFIA; NFIB; NFIC; NFIX; POLR1C; POLR1D; POLR2E; POLR2H; POLR2K; POLR2L; POLR3E; POLR3G; POLR3H; POLR3K; POU2F1; SNAPC1; SNAPC2; SNAPC3; SNAPC4; SNAPC5; ZNF143"
"R-HSA-749476","RNA Polymerase III Abortive And Retractive Initiation",-0.0146013651719404,0.0426051687405555,0.731814029010559,25,"BRF1; CRCP; GTF3A; GTF3C2; NFIA; NFIB; NFIC; NFIX; POLR1C; POLR1D; POLR2E; POLR2H; POLR2K; POLR2L; POLR3E; POLR3G; POLR3H; POLR3K; POU2F1; SNAPC1; SNAPC2; SNAPC3; SNAPC4; SNAPC5; ZNF143"
"R-HSA-6806834","Signaling by MET",-0.00986503603366379,0.0289244093304774,0.733056409407578,36,"ARF6; CBL; CRK; CRKL; DOCK7; EPS15; GAB1; GRB2; ITGA2; ITGA3; KRAS; LAMA1; LAMA2; LAMA5; LAMB3; LAMC1; LAMC3; LRIG1; MET; MUC20; PIK3CA; PIK3R1; PTPN11; PTPN2; PTPRJ; RANBP10; RANBP9; RAP1A; SH3GL2; SRC; STAM; STAM2; STAT3; TNS3; UBA52; UBC"
"R-HSA-6794362","Protein-protein interactions at synapses",-0.0293564522589691,0.0861093305452639,0.733163289637702,33,"APBA2; BEGAIN; DBNL; DLGAP1; EPB41; EPB41L2; EPB41L5; FLOT1; GRIA1; GRIN2A; GRIN2D; GRM1; HOMER1; HOMER2; HOMER3; IL1RAP; LIN7A; LIN7B; LIN7C; LRFN1; LRFN2; LRFN4; LRRTM1; LRRTM2; NLGN1; NLGN2; NRXN1; PDLIM5; PPFIA1; PPFIA2; PPFIA4; PPFIBP1; PPFIBP2"
"R-HSA-112382","Formation of RNA Pol II elongation complex ",-0.00869650254966332,0.0265069355924638,0.742848120038263,32,"AFF4; CCNK; CCNT1; CCNT2; CDK7; CDK9; EAF2; ELL; ERCC2; ERCC3; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; LEO1; MLLT1; NCBP1; NCBP2; NELFA; NELFB; NELFCD; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L; SUPT16H; SUPT5H"
"R-HSA-75955","RNA Polymerase II Transcription Elongation",-0.00869650254966332,0.0265069355924638,0.742848120038263,32,"AFF4; CCNK; CCNT1; CCNT2; CDK7; CDK9; EAF2; ELL; ERCC2; ERCC3; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; LEO1; MLLT1; NCBP1; NCBP2; NELFA; NELFB; NELFCD; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L; SUPT16H; SUPT5H"
"R-HSA-5689880","Ub-specific processing proteases",0.00944378512258076,0.0288291890888783,0.743231361146592,31,"ADRB2; ARRB1; ARRB2; AXIN1; BIRC2; CCNA1; CCNA2; CDC25A; CFTR; CYLD; DDX58; FKBP8; HIF1A; HIST1H2AB; HIST1H2AC; HIST1H2BB; HIST1H2BC; HIST1H2BD; HIST1H2BJ; HIST1H2BL; HIST1H2BN; HIST2H2BF; IL33; MAP3K7; MDM2; MDM4; MUL1; MYC; NFKBIA; OTUB1; PSMA1"
"R-HSA-211976","Endogenous sterols",-0.0279122735020908,0.086676064481193,0.7474301381965,12,"ARNT; ARNT2; CYP1B1; CYP39A1; CYP4V2; CYP51A1; CYP7B1; FDX1; FDXR; NCOA1; POMC; RXRA"
"R-HSA-8941326","RUNX2 regulates bone development",-0.0156948046519113,0.0489058784255324,0.748272099555104,13,"HDAC3; HDAC4; HES1; HEY2; MAPK1; MAPK3; RB1; RBM14; RUNX2; SATB2; SMAD1; SRC; YES1"
"R-HSA-5365859","RA biosynthesis pathway",0.0331661259959201,0.10453367733263,0.751033468100142,14,"AKR1C3; ALDH1A1; ALDH1A2; ALDH1A3; ALDH8A1; CYP26A1; CYP26B1; DHRS3; DHRS4; RDH10; RDH11; RDH13; RDH14; SDR16C5"
"R-HSA-1257604","PIP3 activates AKT signaling",-0.00957365395479256,0.0302340657851221,0.751508262691577,31,"AGO2; AKT1; AKT2; AKT3; ATN1; BTC; CASP9; CBX4; CDKN1A; CDKN1B; CNOT6L; CREB1; CSNK2A2; EGF; EGFR; EGR1; ERBB2; ERBB3; ERBB4; ESR1; ESR2; EZH2; FGF1; FGF10; FGF17; FGF5; FGF9; FGFR1; FGFR2; FOXO1; FRK"
"R-HSA-6804757","Regulation of TP53 Degradation",-0.00828706285128034,0.028253793966012,0.769286764989835,22,"AKT1; AKT2; AKT3; ATM; CCNA1; CCNA2; CCNG1; CDK2; MDM2; MDM4; MLST8; MTOR; PPP2CA; PPP2R1A; PPP2R1B; PPP2R5C; PRR5; RFFL; RICTOR; TP53; UBA52; UBC"
"R-HSA-5693537","Resolution of D-Loop Structures",-0.0141962193448259,0.0495218084788631,0.774368064261122,19,"ATM; BARD1; BLM; BRCA2; BRIP1; DNA2; EME2; EXO1; NBN; PALB2; RAD50; RAD51B; RAD51C; RMI1; RMI2; SPIDR; TOP3A; WRN; XRCC2"
"R-HSA-5693568","Resolution of D-loop Structures through Holliday Junction Intermediates",-0.0141962193448259,0.0495218084788631,0.774368064261122,19,"ATM; BARD1; BLM; BRCA2; BRIP1; DNA2; EME2; EXO1; NBN; PALB2; RAD50; RAD51B; RAD51C; RMI1; RMI2; SPIDR; TOP3A; WRN; XRCC2"
"R-HSA-6806003","Regulation of TP53 Expression and Degradation",-0.00805706495011901,0.0282432217648269,0.775434010773088,23,"AKT1; AKT2; AKT3; ATM; CCNA1; CCNA2; CCNG1; CDK2; MDM2; MDM4; MLST8; MTOR; PPP2CA; PPP2R1A; PPP2R1B; PPP2R5C; PRDM1; PRR5; RFFL; RICTOR; TP53; UBA52; UBC"
"R-HSA-167172","Transcription of the HIV genome",-0.00718698398329726,0.0257424640355446,0.780100643657449,38,"CCNK; CCNT1; CCNT2; CDK7; CDK9; ELL; ERCC2; ERCC3; GTF2A1; GTF2A2; GTF2E1; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; NCBP1; NCBP2; NELFA; NELFB; NELFCD; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L; RNGTT; SUPT16H; SUPT5H; TAF10; TAF11; TAF12; TAF2; TAF4; TAF4B"
"R-HSA-5362517","Signaling by Retinoic Acid",-0.0208118722612096,0.074778526442751,0.780771725735592,23,"AKR1C3; ALDH1A1; ALDH1A2; ALDH1A3; ALDH8A1; CPT1A; CYP26A1; CYP26B1; DHRS3; DHRS4; DLAT; DLD; PDHB; PDHX; PDK2; RARG; RDH10; RDH11; RDH13; RDH14; RXRA; RXRG; SDR16C5"
"R-HSA-9006931","Signaling by Nuclear Receptors",-0.0208118722612096,0.074778526442751,0.780771725735592,23,"AKR1C3; ALDH1A1; ALDH1A2; ALDH1A3; ALDH8A1; CPT1A; CYP26A1; CYP26B1; DHRS3; DHRS4; DLAT; DLD; PDHB; PDHX; PDK2; RARG; RDH10; RDH11; RDH13; RDH14; RXRA; RXRG; SDR16C5"
"R-HSA-168273","Influenza Viral RNA Transcription and Replication",0.00638335137893954,0.0237084445973752,0.787742087674969,36,"AAAS; DNAJC3; GTF2F2; HSP90AA1; IPO5; NDC1; NUP107; NUP205; NUP214; NUP35; NUP37; NUP43; NUP50; NUP54; NUP62; NUP85; NUP88; NUP93; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L; POM121; POM121C; RAE1; RANBP2; RPL10A; RPL12; RPL13; RPL14; RPL15; RPL17"
"R-HSA-3295583","TRP channels",0.0519868226717743,0.194916201356308,0.789689599239774,10,"MCOLN1; TRPA1; TRPC1; TRPC6; TRPM2; TRPM3; TRPM7; TRPV2; TRPV3; TRPV6"
"R-HSA-70268","Pyruvate metabolism",-0.0251683774708889,0.0959542409732838,0.793093535827338,13,"BSG; DLAT; DLD; GLO1; HAGH; LDHB; MPC1; MPC2; PDHB; PDHX; PDK2; RXRA; SLC16A1"
"R-HSA-167152","Formation of HIV elongation complex in the absence of HIV Tat",-0.00696896095257703,0.0267324647696413,0.794329422904094,28,"CCNK; CCNT1; CCNT2; CDK7; CDK9; ELL; ERCC2; ERCC3; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; NCBP1; NCBP2; NELFA; NELFB; NELFCD; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L; SUPT16H; SUPT5H"
"R-HSA-8876384","Listeria monocytogenes entry into host cells",-0.00958910852831214,0.0381969966397116,0.801780461430682,12,"CBL; CBLL1; CDH1; EPS15; GRB2; MET; SH3GL2; SRC; STAM; STAM2; UBA52; UBC"
"R-HSA-1483166","Synthesis of PA",0.0285704301457011,0.113811245386534,0.801788243823826,17,"ACP6; AGPAT3; AGPAT4; DDHD1; DDHD2; GPAM; GPAT2; GPD1L; GPD2; LCLAT1; LPCAT1; PLA2G12A; PLA2G4B; PLA2G5; PLD1; PLD2; PLD6"
"R-HSA-8978868","Fatty acid metabolism",0.0150011885542565,0.0611727958187605,0.806281084741849,38,"ABCC1; ACAA2; ACACA; ACADL; ACADM; ACADS; ACADVL; ACBD4; ACBD5; ACBD6; ACBD7; ACLY; ACOT1; ACOT11; ACOT2; ACOT4; ACOT8; ACOX2; ACOX3; ACSF2; ACSF3; ACSL1; ACSL5; ACSL6; AKR1C3; ALDH3A2; ALOX5; ALOX5AP; AMACR; CBR1; CBR4; CPT1A; CPT2; CRAT; CYP1B1; CYP2C8; CYP2J2; CYP2U1"
"R-HSA-399954","Sema3A PAK dependent Axon repulsion",0.0152738596531813,0.0630848948776256,0.808690314609392,13,"CFL1; FES; FYN; HSP90AA1; HSP90AB1; LIMK1; NRP1; PAK1; PAK2; PLXNA1; PLXNA2; PLXNA4; SEMA3A"
"R-HSA-5339562","Uptake and actions of bacterial toxins",0.0137255211188318,0.0571741060874017,0.810279604594326,18,"ANTXR1; ANTXR2; CALM1; CD9; EEF2; FURIN; HSP90AA1; HSP90AB1; MAP2K6; MAP2K7; PDCD6IP; SV2A; SV2C; SYT1; SYT2; TXNRD1; VAMP1; VAMP2"
"R-HSA-76046","RNA Polymerase III Transcription Initiation",-0.01003622202839,0.0433704652012349,0.816998756704329,21,"BRF1; CRCP; GTF3A; GTF3C2; POLR1C; POLR1D; POLR2E; POLR2H; POLR2K; POLR2L; POLR3E; POLR3G; POLR3H; POLR3K; POU2F1; SNAPC1; SNAPC2; SNAPC3; SNAPC4; SNAPC5; ZNF143"
"R-HSA-8940973","RUNX2 regulates osteoblast differentiation",0.0115749082072454,0.0511757431182753,0.821061750051474,10,"HDAC3; HES1; HEY2; MAPK1; MAPK3; RB1; RUNX2; SATB2; SRC; YES1"
"R-HSA-2559583","Cellular Senescence",0.00730967252843722,0.0331279547501694,0.825365217255993,31,"ACD; ANAPC16; ANAPC4; ANAPC5; ASF1A; ATM; CABIN1; CBX4; CCNA1; CCNA2; CDC16; CDK2; CDK6; CDKN1A; CDKN1B; CDKN2B; CDKN2C; CEBPB; E2F1; EHMT1; EP400; ERF; EZH2; H1F0; H2AFV; H2AFZ; H3F3A; HIST1H1A; HIST1H1C; HIST1H1D; HIST1H2AB"
"R-HSA-5655332","Signaling by FGFR3 in disease",-0.00848660028358157,0.0389424202946133,0.827486080649832,10,"FGF1; FGF17; FGF5; FGF9; GAB1; GRB2; KRAS; PIK3CA; PIK3R1; PLCG1"
"R-HSA-8853338","Signaling by FGFR3 point mutants in cancer",-0.00848660028358157,0.0389424202946133,0.827486080649832,10,"FGF1; FGF17; FGF5; FGF9; GAB1; GRB2; KRAS; PIK3CA; PIK3R1; PLCG1"
"R-HSA-168276","NS1 Mediated Effects on Host Pathways",0.00660477729197215,0.030671726735594,0.829504084360382,23,"AAAS; CPSF4; KPNA3; KPNA4; KPNA5; NDC1; NUP107; NUP205; NUP214; NUP35; NUP37; NUP43; NUP50; NUP54; NUP62; NUP85; NUP88; NUP93; POM121; POM121C; RAE1; RANBP2; SEH1L"
"R-HSA-1296071","Potassium Channels",0.0112989743199931,0.0539455711394252,0.834095886678886,27,"ABCC8; ABCC9; GNB2; GNB3; GNG4; GNG5; GNG7; HCN2; KCNA1; KCNA4; KCNAB1; KCNAB3; KCNB1; KCNB2; KCNC1; KCNC2; KCNC4; KCNG1; KCNH5; KCNH7; KCNH8; KCNJ11; KCNJ14; KCNJ16; KCNJ3; KCNJ4; KCNJ8"
"R-HSA-196741","Cobalamin (Cbl, vitamin B12) transport and metabolism",-0.024005136147167,0.115705008050999,0.83564404694684,11,"ABCC1; ABCD4; CD320; CUBN; LMBRD1; MMAA; MMAB; MTR; MTRR; PRSS3; TCN2"
"R-HSA-428157","Sphingolipid metabolism",0.0171490440037777,0.0827775578067259,0.835876931866071,34,"ACER2; ALDH3A2; ARSA; ARSB; ASAH1; ASAH2; B4GALNT1; CERS4; CERS5; CERS6; CTSA; DEGS1; ESYT1; ESYT2; ESYT3; GALC; GBA2; GLB1; GM2A; HEXA; HEXB; KDSR; NEU3; NEU4; ORMDL1; ORMDL2; ORMDL3; OSBP; PPM1L; PRKD1; PRKD2; PRKD3; PSAP; SAMD8"
"R-HSA-376176","Signaling by ROBO receptors",-0.0063787702640804,0.0333904943056794,0.848497768849148,29,"ABL2; AKAP5; ARHGAP39; CASC3; DAG1; DCC; ENAH; ETF1; LDB1; LHX2; MAGOHB; NCBP1; NCBP2; NCK1; NRP1; NTN1; PAK1; PAK2; PAK4; PFN1; PFN2; PPP3CB; PRKACA; PRKAR2A; PRKCA; PSMA1; PSMA4; PSMA5; PSMA7"
"R-HSA-3769402","Deactivation of the beta-catenin transactivating complex",0.00673413935214839,0.0361472707974539,0.85221161600784,18,"AKT1; AKT2; ASH2L; BTRC; CBY1; CTNNBIP1; HDAC1; KMT2D; PYGO2; RBBP5; SOX4; SOX6; TLE3; TLE4; UBA52; UBC; XPO1; YWHAZ"
"R-HSA-420092","Glucagon-type ligand receptors",0.00935811733255869,0.0503486688303007,0.852549664145465,13,"ADCYAP1; ADCYAP1R1; GLP2R; GNB2; GNB3; GNB4; GNB5; GNG11; GNG4; GNG5; GNG7; VIPR1; VIPR2"
"R-HSA-1483191","Synthesis of PC",-0.0161274963463985,0.0948146773823711,0.864935477089985,18,"ACHE; BCHE; CEPT1; CHKA; CHKB; CHPT1; CSNK2A2; LPCAT1; LPIN1; LPIN2; LPIN3; PCTP; PCYT1A; PEMT; SLC44A3; SLC44A5; STARD10; STARD7"
"R-HSA-420499","Class C/3 (Metabotropic glutamate/pheromone receptors)",-0.0324443171059546,0.196866129472159,0.869098289518878,16,"GRM1; GRM2; GRM3; GRM6; GRM7; GRM8; TAS2R10; TAS2R13; TAS2R14; TAS2R19; TAS2R20; TAS2R30; TAS2R31; TAS2R4; TAS2R5; TAS2R50"
"R-HSA-416482","G alpha (12/13) signalling events",0.00561576638596146,0.0357094392805391,0.875037737185284,37,"ABR; ADRA1A; ADRA1B; AKAP13; ARHGEF1; ARHGEF10; ARHGEF10L; ARHGEF11; ARHGEF12; ARHGEF18; ARHGEF3; ARHGEF33; ARHGEF4; ARHGEF40; ECT2; FGD2; FGD3; FGD4; GNA12; GNA13; GNB2; GNB3; GNB4; GNB5; GNG11; GNG4; GNG5; GNG7; ITSN1; KALRN; MCF2L; OBSCN; PIK3CA; PIK3R1; PLEKHG2; PLEKHG5; PLXNB1"
"R-HSA-381070","IRE1alpha activates chaperones",0.0101445993049339,0.0706478619453531,0.885821188217737,34,"ACADVL; ADD1; ATP6V0D1; CUL7; DDX11; DNAJB11; DNAJB9; DNAJC3; ERN1; EXTL2; GOSR2; HDGF; HSPA5; KDELR3; PDIA6; PLA2G4B; PREB; SEC61A2; SEC61B; SEC61G; SEC62; SEC63; SERP1; SRPRB; SSR1; SYVN1; TATDN2; TLN1; TPP1; WFS1; WIPI1; XBP1; YIF1A; ZBTB17"
"R-HSA-8948751","Regulation of PTEN stability and activity",-0.00245628356524524,0.0188145285413333,0.896129327759304,39,"AKT1; AKT2; AKT3; CSNK2A2; FRK; NEDD4; OTUD3; PREX2; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; PTEN; RNF146; TNKS; TNKS2; TRIM27; UBA52; UBC; USP13; WWP2"
"R-HSA-418360","Platelet calcium homeostasis",0.00866467337662655,0.0683491141900648,0.899121790192462,17,"ATP2A2; ATP2B1; ATP2B4; CALM1; ITPR2; ITPR3; ORAI2; P2RX4; P2RX5; P2RX6; P2RX7; SLC8A1; SLC8A2; SLC8A3; SRI; STIM1; TRPC6"
"R-HSA-1227986","Signaling by ERBB2",-0.00318579282306036,0.0254249284406123,0.900284517478876,30,"AKT1; AKT2; AKT3; BTC; CDC37; CUL5; DIAPH1; EGF; EGFR; ERBB2; ERBB3; ERBB4; FYN; GAB1; GRB2; HSP90AA1; KRAS; NRG2; NRG4; PIK3CA; PIK3R1; PLCG1; PRKCA; PRKCD; PTPN12; PTPN18; SRC; UBA52; UBC; YES1"
"R-HSA-156827","L13a-mediated translational silencing of Ceruloplasmin expression",0.00496076673659141,0.0411294914149062,0.903997275144999,32,"EIF2S1; EIF3A; EIF3B; EIF3C; EIF3E; EIF3F; EIF3H; EIF3I; EIF3L; EIF4A1; EIF4A2; EIF4B; EIF4E; RPL10A; RPL12; RPL13; RPL14; RPL15; RPL17; RPL23; RPL26; RPL26L1; RPL27; RPL27A; RPL29; RPL3; RPL31; RPL35; RPL36; RPL36AL; RPL37A; RPL4"
"R-HSA-72706","GTP hydrolysis and joining of the 60S ribosomal subunit",0.00496076673659141,0.0411294914149062,0.903997275144999,32,"EIF2S1; EIF3A; EIF3B; EIF3C; EIF3E; EIF3F; EIF3H; EIF3I; EIF3L; EIF4A1; EIF4A2; EIF4B; EIF4E; RPL10A; RPL12; RPL13; RPL14; RPL15; RPL17; RPL23; RPL26; RPL26L1; RPL27; RPL27A; RPL29; RPL3; RPL31; RPL35; RPL36; RPL36AL; RPL37A; RPL4"
"R-HSA-977443","GABA receptor activation",0.00508772375313959,0.0492677669533931,0.917751238703128,17,"ADCY3; ADCY6; ADCY7; GABRA2; GABRA4; GABRA6; GABRB1; GABRG3; GNAI2; GNB2; GNB3; GNG4; GNG5; GNG7; KCNJ16; KCNJ3; KCNJ4"
"R-HSA-380994","ATF4 activates genes",0.00784804076584513,0.0764050059746757,0.918188123552653,16,"ASNS; ATF3; ATF4; ATF6; CCL2; DCP2; EXOSC2; EXOSC3; EXOSC4; EXOSC5; EXOSC6; EXOSC8; EXOSC9; NFYB; NFYC; PARN"
"R-HSA-1295596","Spry regulation of FGF signaling",0.00314026551588391,0.0315360251975045,0.920680085543774,12,"CBL; GRB2; MAPK1; MAPK3; MKNK1; PPP2CA; PPP2R1A; PTPN11; SPRY2; SRC; UBA52; UBC"
"R-HSA-2262752","Cellular responses to stress",0.00337125180904317,0.034421820991101,0.92198042950619,30,"AAAS; ACD; ACTR10; AJUBA; ANAPC16; ANAPC4; ANAPC5; ARNT; ASF1A; ATM; BAG2; BAG4; BAG5; CABIN1; CAMK2B; CAMK2D; CAPZA2; CAPZB; CAT; CBX4; CCNA1; CCNA2; CDC16; CDK2; CDK6; CDKN1A; CDKN1B; CDKN2B; CDKN2C; CEBPB"
"R-HSA-399955","SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion",-0.00731634364309656,0.0899430697424049,0.935168254071086,10,"FARP2; FES; FYN; NRP1; PLXNA1; PLXNA2; PLXNA4; RND1; SEMA3A; TLN1"
"R-HSA-1362409","Mitochondrial iron-sulfur cluster biogenesis",-0.0141263014735663,0.176841058508011,0.936331627533321,11,"FDX1; FDXR; FXN; GLRX5; ISCA1; ISCA2; ISCU; LYRM4; NFS1; SLC25A28; SLC25A37"
"R-HSA-425407","SLC-mediated transmembrane transport",0.00509830655893845,0.0690992844362968,0.941183583262626,29,"BSG; CALM1; CP; CTNS; EMB; LCN12; LCN15; RUNX1; SLC11A1; SLC12A1; SLC12A2; SLC12A5; SLC12A6; SLC12A7; SLC13A3; SLC13A4; SLC14A1; SLC15A2; SLC15A3; SLC15A4; SLC16A1; SLC16A10; SLC17A5; SLC17A6; SLC18A2; SLC1A1; SLC1A3; SLC1A4; SLC1A6"
"R-HSA-425393","Transport of inorganic cations/anions and amino acids/oligopeptides",-0.00507961117841828,0.0728118179930352,0.944381856361063,34,"CALM1; CTNS; SLC12A1; SLC12A2; SLC12A5; SLC12A6; SLC12A7; SLC15A2; SLC15A3; SLC15A4; SLC16A10; SLC17A5; SLC17A6; SLC1A1; SLC1A3; SLC1A4; SLC1A6; SLC24A2; SLC24A5; SLC25A10; SLC25A22; SLC25A26; SLC25A29; SLC26A1; SLC26A11; SLC26A4; SLC36A1; SLC36A4; SLC38A2; SLC38A3; SLC43A1; SLC4A10; SLC4A3; SLC4A4"
"R-HSA-69239","Synthesis of DNA",-0.00145727075533368,0.0220325973824265,0.947265108955898,36,"CCNA1; CCNA2; CDK2; CDKN1A; CDKN1B; DNA2; FEN1; GINS2; GINS4; LIG1; MCM2; MCM3; MCM4; MCM6; MCM7; MCM8; ORC2; ORC4; ORC5; POLA2; POLD2; POLD3; POLE; PRIM1; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5"
"R-HSA-5627123","RHO GTPases activate PAKs",0.00423714678286846,0.0671637532487677,0.949697379335919,10,"CALM1; LIMK1; MYH10; MYH11; MYH14; MYH9; MYLK; PAK1; PAK2; PPP1CB"
"R-HSA-4085001","Sialic acid metabolism",0.00489355335874238,0.0805053299776633,0.951530071693882,24,"CTSA; GLB1; GNE; NANP; NANS; NEU3; NEU4; NPL; SLC17A5; SLC35A1; ST3GAL1; ST3GAL2; ST3GAL3; ST3GAL4; ST3GAL5; ST3GAL6; ST6GAL1; ST6GAL2; ST6GALNAC2; ST6GALNAC4; ST6GALNAC5; ST8SIA1; ST8SIA3; ST8SIA6"
"R-HSA-379716","Cytosolic tRNA aminoacylation",-0.0068315656926845,0.131563629436695,0.958587701603994,13,"AIMP1; CARS; FARSA; FARSB; GARS; HARS; IARS; KARS; LARS; PPA1; QARS; RARS; SARS"
"R-HSA-432720","Lysosome Vesicle Biogenesis",0.00248578060462096,0.0502651881234922,0.960558034174637,22,"AP1B1; AP1M1; AP1S1; AP4B1; AP4E1; AP4S1; APP; ARF1; ARRB1; CHMP2A; CLTA; CLVS2; CTSZ; DNAJC6; DNASE2; DNM2; HSPA8; M6PR; SH3GL2; TXNDC5; VAMP2; VAMP8"
"R-HSA-174178","APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1",0.000960987017847516,0.0198971989514444,0.961479064771981,29,"ANAPC16; ANAPC4; ANAPC5; CDC16; PLK1; PSMA1; PSMA4; PSMA5; PSMA7; PSMB10; PSMB2; PSMB4; PSMB5; PSMB6; PSMC1; PSMC3; PSMC5; PSMD11; PSMD13; PSMD2; PSMD4; PSMD5; PSMD6; PSMD7; PSME2; PSME4; PSMF1; SKP2; UBA52"
"R-HSA-211897","Cytochrome P450 - arranged by substrate type",0.00252626086030528,0.0753236152988397,0.973244955031518,23,"ARNT; ARNT2; CYP1B1; CYP26A1; CYP26B1; CYP2C8; CYP2E1; CYP2J2; CYP2R1; CYP2U1; CYP39A1; CYP4F11; CYP4F3; CYP4V2; CYP51A1; CYP7B1; FDX1; FDXR; NCOA1; POMC; POR; RXRA; TBXAS1"
"R-HSA-140877","Formation of Fibrin Clot (Clotting Cascade)",0.00405138453673574,0.122570758562349,0.97363197634542,14,"A2M; C1QBP; F12; F2R; F3; F5; F7; KLKB1; PRCP; PROCR; PROS1; SERPING1; TFPI; VWF"
"R-HSA-1839124","FGFR1 mutant receptor activation",-0.00129023612946607,0.0410887526073327,0.974949584335808,15,"BAG4; BCR; CNTRL; ERLIN2; FGF1; FGF17; FGF5; FGF9; FGFR1; GRB2; LRRFIP1; PIK3CA; PIK3R1; STAT3; TRIM24"
"R-HSA-6794361","Neurexins and neuroligins",0.00302257083418924,0.0965416894664159,0.975023550128419,30,"APBA2; BEGAIN; DBNL; DLGAP1; EPB41; EPB41L2; EPB41L5; GRIN2A; GRIN2D; GRM1; HOMER1; HOMER2; HOMER3; LIN7A; LIN7B; LIN7C; LRRTM1; LRRTM2; NLGN1; NLGN2; NRXN1; PDLIM5; SHANK1; SHANK2; SIPA1L1; SYT1; SYT10; SYT12; SYT2; SYT9"
"R-HSA-379724","tRNA Aminoacylation",0.00250651018304686,0.098395289974015,0.979676979436036,27,"AARS2; AIMP1; CARS; CARS2; DARS2; EARS2; FARS2; FARSA; FARSB; GARS; HARS; HARS2; IARS; KARS; LARS; LARS2; NARS2; PARS2; PPA1; PPA2; QARS; RARS; RARS2; SARS; TARS2; VARS2; WARS2"
"R-HSA-76071","RNA Polymerase III Transcription Initiation From Type 3 Promoter",0.00107551530280851,0.0444947684649687,0.980715631799863,18,"CRCP; POLR1C; POLR1D; POLR2E; POLR2H; POLR2K; POLR2L; POLR3E; POLR3G; POLR3H; POLR3K; POU2F1; SNAPC1; SNAPC2; SNAPC3; SNAPC4; SNAPC5; ZNF143"
"R-HSA-983712","Ion channel transport",-0.00139030587569967,0.0616140453505803,0.981997457610938,35,"ANO10; ANO2; ANO3; ANO5; ASIC1; ASIC2; ASPH; ATP10B; ATP10D; ATP11A; ATP11B; ATP13A2; ATP13A5; ATP1A1; ATP1A3; ATP1B1; ATP1B2; ATP1B3; ATP2A2; ATP2B1; ATP2B4; ATP2C1; ATP2C2; ATP6V0A2; ATP6V0B; ATP6V0C; ATP6V0D1; ATP6V0E1; ATP6V0E2; ATP6V1C1; ATP6V1C2; ATP6V1E1; ATP6V1E2; ATP6V1G1; ATP6V1H"
"R-HSA-5674400","Constitutive Signaling by AKT1 E17K in Cancer",-0.000937621802366495,0.0416081033301147,0.982021515316625,15,"AKT1; AKT2; AKT3; CASP9; CDKN1A; CDKN1B; CREB1; FOXO1; GSK3B; MDM2; MLST8; MTOR; NR4A1; PRR5; RICTOR"
"R-HSA-977444","GABA B receptor activation",0.00102561346576727,0.0499759716967337,0.983626857364963,12,"ADCY3; ADCY6; ADCY7; GNAI2; GNB2; GNB3; GNG4; GNG5; GNG7; KCNJ16; KCNJ3; KCNJ4"
"R-HSA-991365","Activation of GABAB receptors",0.00102561346576727,0.0499759716967337,0.983626857364963,12,"ADCY3; ADCY6; ADCY7; GNAI2; GNB2; GNB3; GNG4; GNG5; GNG7; KCNJ16; KCNJ3; KCNJ4"
"R-HSA-1793185","Chondroitin sulfate/dermatan sulfate metabolism",0.000866864087574683,0.0720263461271507,0.990397391905194,26,"ARSB; B3GALT6; B3GAT1; B3GAT2; CHPF; CHST11; CHST12; CHST3; CHST9; CHSY3; CSGALNACT1; CSGALNACT2; DCN; DSE; GPC5; HEXA; HEXB; HSPG2; HYAL1; HYAL3; NCAN; SDC2; SDC3; UST; XYLT1; XYLT2"
"R-HSA-168255","Influenza Life Cycle",-0.000117432855637996,0.0235580095225616,0.996022691377525,37,"AAAS; CALR; CANX; CLTA; DNAJC3; GTF2F2; HSP90AA1; IPO5; NDC1; NUP107; NUP205; NUP214; NUP35; NUP37; NUP43; NUP50; NUP54; NUP62; NUP85; NUP88; NUP93; POLR2A; POLR2B; POLR2D; POLR2E; POLR2H; POLR2I; POLR2K; POLR2L; POM121; POM121C; RAE1; RAN; RANBP2; RPL10A; RPL12; RPL13"
"R-HSA-168249","Innate Immune System",0.0001352019167258,0.0394495899558988,0.997265489682209,39,"ABI2; ACLY; ACTB; ACTG1; ACTR10; ACTR1B; ACTR2; ADAM10; ADAM8; AGA; AGL; AHCYL1; ALAD; ALDOC; ALOX5; AMPD3; ANXA2; AP1M1; AP2A2; APOB; APP; APRT; ARHGAP9; ARMC8; ARPC1A; ARPC1B; ARPC2; ARPC3; ARPC4; ARSA; ARSB; ASAH1; ATAD3B; ATF1; ATG12; ATG7; ATP11A; ATP11B; ATP6V0A2"