"pathway","name","coef","se","p","n_genes","genes"
"R-HSA-8956319","Nucleobase catabolism",0.795333385994132,0.193127359163493,3.81875018623214e-05,32,"ADPRM; DNPH1; DPYD; DPYS; ENTPD1; ENTPD2; ENTPD3; ENTPD4; ENTPD5; ENTPD6; ENTPD7; ENTPD8; GDA; GPX1; ITPA; NT5C; NT5C1A; NT5C1B; NT5C2; NT5C3A; NT5E; NT5M; NUDT15; NUDT16; NUDT5; NUDT9; PNP; TYMP; UPB1; UPP1; UPP2; XDH"
"R-HSA-983170","Antigen Presentation: Folding, assembly and peptide loading of class I MHC",0.897822909964047,0.222819870371487,5.59273780637206e-05,21,"B2M; CALR; CANX; ERAP1; ERAP2; HLA-A; HLA-B; HLA-C; HLA-E; HLA-F; HLA-G; PDIA3; SAR1B; SEC13; SEC24A; SEC24B; SEC24C; SEC24D; TAP1; TAP2; TAPBP"
"R-HSA-196108","Pregnenolone biosynthesis",-0.888985818222249,0.279373913895342,0.00146229240576541,12,"AKR1B1; CYP11A1; FDX1; FDX2; FDXR; STAR; STARD3; STARD3NL; STARD4; STARD6; TSPO; TSPOAP1"
"R-HSA-427413","NoRC negatively regulates rRNA expression",0.569132811261128,0.180260308364939,0.00159246700951868,46,"ARID4B; BAZ2A; CCNH; CDK7; DNMT1; DNMT3B; ERCC3; GTF2H1; GTF2H2; GTF2H3; GTF2H4; GTF2H5; H2AFJ; H2AFV; H2AFX; H2AFZ; H2BFS; H3F3A; HDAC1; HDAC2; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HIST2H2AA3; HIST2H2AC; MBD2; MNAT1; POLR1A; POLR1B; POLR1C; POLR1D; POLR1E; POLR2E; POLR2F; POLR2H; POLR2K; POLR2L; SAP130; SAP18; SAP30; SAP30BP; SAP30L; SIN3B; SMARCA5; SUDS3"
"R-HSA-75067","Processing of Capped Intronless Pre-mRNA",0.739922935976891,0.237732079281454,0.00185558030428401,22,"CLP1; CPSF1; CPSF2; CPSF3; CPSF4; CPSF7; CSTF1; CSTF2T; CSTF3; FIP1L1; LSM10; LSM11; NCBP1; NCBP2; NUDT21; PAPOLA; SLBP; SNRPB; SNRPD3; SNRPE; SNRPF; ZNF473"
"R-HSA-5250941","Negative epigenetic regulation of rRNA expression",0.556938987324286,0.181147765867264,0.00210855014507896,46,"ARID4B; BAZ2A; CCNH; CDK7; DNMT1; DNMT3B; ERCC3; GTF2H1; GTF2H2; GTF2H3; GTF2H4; GTF2H5; H2AFJ; H2AFV; H2AFX; H2AFZ; H2BFS; H3F3A; HDAC1; HDAC2; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HIST2H2AA3; HIST2H2AC; MBD2; MNAT1; POLR1A; POLR1B; POLR1C; POLR1D; POLR1E; POLR2E; POLR2F; POLR2H; POLR2K; POLR2L; RRP8; SAP130; SAP18; SAP30; SAP30BP; SAP30L; SIN3B; SIRT1"
"R-HSA-5661231","Metallothioneins bind metals",-0.911732512910127,0.298064036151597,0.00222190021497129,10,"MT1A; MT1B; MT1E; MT1F; MT1G; MT1M; MT1X; MT2A; MT3; MT4"
"R-HSA-5689603","UCH proteinases",0.535634897903766,0.175421823016374,0.00226255936596417,50,"ACTL6A; ACTR5; ACTR8; ADRM1; ASXL2; BAP1; BARD1; FOXK1; FOXK2; HIST1H2AG; HIST2H2AA3; HIST2H2AC; HIST3H2A; INO80; INO80B; INO80C; INO80D; INO80E; KDM1B; MBD5; MBD6; MCRS1; NEDD8; NFRKB; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3"
"R-HSA-73621","Pyrimidine catabolism",0.875721407313136,0.307365814294661,0.00438406471284332,11,"DPYD; DPYS; NT5C; NT5C1A; NT5C3A; NT5E; NT5M; TYMP; UPB1; UPP1; UPP2"
"R-HSA-77595","Processing of Intronless Pre-mRNAs",0.807848847144185,0.284884956422283,0.00457250857153692,14,"CLP1; CPSF1; CPSF2; CPSF3; CPSF4; CPSF7; CSTF1; CSTF2T; CSTF3; FIP1L1; NCBP1; NCBP2; NUDT21; PAPOLA"
"R-HSA-74259","Purine catabolism",0.769615769374777,0.27293135611629,0.00480514325257308,16,"ADPRM; DNPH1; GDA; GPX1; ITPA; NT5C; NT5C1A; NT5C1B; NT5C2; NT5E; NUDT15; NUDT16; NUDT5; NUDT9; PNP; XDH"
"R-HSA-72306","tRNA processing",-0.641989616903976,0.229889510262747,0.0052286183549302,26,"ADAT1; ADAT2; ADAT3; ALKBH8; C14orf166; C2orf49; CDKAL1; CLP1; CPSF1; CPSF4; CTU1; CTU2; DDX1; DUS2; ELAC2; EPRS; FAM98B; GTPBP3; KIAA0391; KIAA1456; LCMT2; METTL1; MTO1; NDC1; NSUN2; NSUN6"
"R-HSA-6799198","Complex I biogenesis",-0.509575678696727,0.186131071789509,0.00618657941973482,46,"ACAD9; ECSIT; NDUFA10; NDUFA11; NDUFA12; NDUFA13; NDUFA2; NDUFA3; NDUFA5; NDUFA6; NDUFA7; NDUFA8; NDUFA9; NDUFAB1; NDUFAF1; NDUFAF2; NDUFAF3; NDUFAF4; NDUFAF5; NDUFAF6; NDUFAF7; NDUFB1; NDUFB10; NDUFB2; NDUFB3; NDUFB4; NDUFB5; NDUFB6; NDUFB8; NDUFB9; NDUFC1; NDUFC2; NDUFS1; NDUFS2; NDUFS3; NDUFS4; NDUFS5; NDUFS6; NDUFS7; NDUFS8; NDUFV1; NDUFV2; NDUFV3; NUBPL; TIMMDC1; TMEM126B"
"R-HSA-196071","Metabolism of steroid hormones",-0.59426760390843,0.220156686426106,0.00694867778318104,30,"AKR1B1; AKR1B15; CGA; CYP11A1; CYP11B1; CYP17A1; CYP19A1; CYP21A2; FDX1; FDX2; FDXR; HSD11B1; HSD17B1; HSD17B11; HSD17B12; HSD17B14; HSD17B2; HSD17B3; HSD3B2; LHB; POMC; SRD5A1; SRD5A3; STAR; STARD3; STARD3NL; STARD4; STARD6; TSPO; TSPOAP1"
"R-HSA-166658","Complement cascade",0.506767024891235,0.188748986773833,0.00725574094831295,44,"C1QA; C1QB; C1QC; C1S; C2; C3; C4A; C4B; C4BPA; C4BPB; C5; C5AR1; C5AR2; C6; C7; C8A; C8B; C8G; C9; CD19; CD46; CD55; CD59; CD81; CFB; CFD; CFH; CFHR1; CFHR3; CFHR4; CFI; CLU; COLEC10; COLEC11; CPN1; CPN2; CR1; CR2; ELANE; F2; FCN1; FCN2; FCN3; GZMM"
"R-HSA-73886","Chromosome Maintenance",-0.499953446325475,0.188852040822495,0.00811304279150671,45,"ACD; CENPA; CENPC; CENPH; CENPK; CENPL; CENPM; CENPN; CENPO; CENPP; CENPQ; CENPT; CENPU; CENPW; DNA2; H2AFJ; H2AFV; H2AFX; H2AFZ; H2BFS; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HIST2H2AA3; HIST2H2AC; HJURP; ITGB3BP; LIG1; MIS18A; MIS18BP1; NHP2; NPM1; OIP5; PCNA; POLA2; POLD1; POLD2; POLD3; POLE; POLE2; POLE3; POLE4; POT1; PRIM1"
"R-HSA-2428928","IRS-related events triggered by IGF1R",0.507249605675465,0.197719157647789,0.0103025559052647,40,"AKT2; FGF1; FGF10; FGF17; FGF18; FGF2; FGF20; FGF22; FGF5; FGF7; FGF9; FGFR1; FGFR2; FGFR3; FGFR4; FRS2; GAB1; GRB2; HRAS; IGF1; IGF1R; IGF2; IRS1; IRS2; KL; KLB; KRAS; NRAS; PDE3B; PDPK1; PIK3C3; PIK3CA; PIK3CB; PIK3R1; PIK3R2; PIK3R4; SOS1; THEM4; TLR9; TRIB3"
"R-HSA-5687128","MAPK6/MAPK4 signaling",0.450819672692459,0.175785428968176,0.0103294196977584,53,"AGO1; AGO2; AGO3; AGO4; CCND3; CDC14A; CDC14B; CDC42; CDC42EP2; CDC42EP3; CDC42EP5; CDK1; DNAJB1; ETV4; FOXO1; FOXO3; HSPB1; KALRN; MAPK4; MAPK6; MAPKAPK5; MMP10; MMP2; MOV10; MYC; NCOA3; PAK1; PAK2; PRKACB; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13"
"R-HSA-1474228","Degradation of the extracellular matrix",-0.416263492416508,0.162666737757805,0.0104975021364362,65,"A2M; ACAN; ADAM10; ADAM15; ADAM17; ADAM8; ADAM9; ADAMTS16; ADAMTS18; ADAMTS4; ADAMTS5; ADAMTS8; ADAMTS9; BCAN; BMP1; BSG; CAPN1; CAPN10; CAPN11; CAPN12; CAPN13; CAPN14; CAPN15; CAPN2; CAPN3; CAPN5; CAPN7; CAPN8; CAPN9; CAPNS1; CAPNS2; CASP3; CAST; CD44; CDH1; CMA1; COL12A1; COL13A1; COL14A1; COL15A1; COL16A1; COL17A1; COL18A1; COL19A1; COL23A1; COL25A1; COL9A1; COL9A2; COL9A3; CTRB1; CTRB2; CTSB; CTSD; CTSG; CTSK; CTSL; CTSS; CTSV; DCN; ELANE; FURIN; HSPG2; HTRA1; KLK2; KLK7"
"R-HSA-6804758","Regulation of TP53 Activity through Acetylation",0.606510638983933,0.238713103879836,0.0110614557007015,25,"AKT1; AKT2; AKT3; BRD7; BRPF3; CHD3; CHD4; EP300; GATAD2A; GATAD2B; HDAC1; HDAC2; ING2; ING5; KAT6A; MAP2K6; MBD3; MEAF6; MTA2; PIN1; PIP4K2A; PIP4K2C; PML; RBBP4; TMEM55B"
"R-HSA-3928662","EPHB-mediated forward signaling",0.542632549729576,0.217491653699435,0.0125972026030081,32,"ACTG1; ACTR2; ACTR3; ARHGEF28; ARPC1A; ARPC1B; ARPC2; ARPC3; ARPC4; ARPC5; CDC42; CFL1; FYN; GRIN1; GRIN2B; HRAS; ITSN1; KALRN; LIMK1; LIMK2; LYN; PAK1; PTK2; RAC1; RASA1; ROCK1; ROCK2; SDC2; SRC; TIAM1; WASL; YES1"
"R-HSA-6804757","Regulation of TP53 Degradation",0.527240152258566,0.215576644336592,0.0144563143737168,33,"AKT1; AKT2; AKT3; ATM; CCNA1; CCNA2; CCNG1; CDK1; CDK2; CDKN2A; CHEK2; DAXX; MAPKAP1; MDM2; MDM4; MLST8; MTOR; PDPK1; PHF20; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5C; PRR5; RFFL; RICTOR; RNF34; SGK1; UBA52; UBC; USP2; USP7"
"R-HSA-6806003","Regulation of TP53 Expression and Degradation",0.527240152258566,0.215576644336592,0.0144563143737168,33,"AKT1; AKT2; AKT3; ATM; CCNA1; CCNA2; CCNG1; CDK1; CDK2; CDKN2A; CHEK2; DAXX; MAPKAP1; MDM2; MDM4; MLST8; MTOR; PDPK1; PHF20; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5C; PRR5; RFFL; RICTOR; RNF34; SGK1; UBA52; UBC; USP2; USP7"
"R-HSA-2404192","Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)",0.475685150134278,0.195311526927077,0.0148703982925163,42,"AKT2; CILP; FGF1; FGF10; FGF17; FGF18; FGF2; FGF20; FGF22; FGF5; FGF7; FGF9; FGFR1; FGFR2; FGFR3; FGFR4; FRS2; GAB1; GRB2; HRAS; IGF1; IGF1R; IGF2; IRS1; IRS2; KL; KLB; KRAS; NRAS; PDE3B; PDPK1; PIK3C3; PIK3CA; PIK3CB; PIK3R1; PIK3R2; PIK3R4; SHC1; SOS1; THEM4; TLR9; TRIB3"
"R-HSA-2428924","IGF1R signaling cascade",0.480036262859344,0.197323786476586,0.0149853096804577,41,"AKT2; FGF1; FGF10; FGF17; FGF18; FGF2; FGF20; FGF22; FGF5; FGF7; FGF9; FGFR1; FGFR2; FGFR3; FGFR4; FRS2; GAB1; GRB2; HRAS; IGF1; IGF1R; IGF2; IRS1; IRS2; KL; KLB; KRAS; NRAS; PDE3B; PDPK1; PIK3C3; PIK3CA; PIK3CB; PIK3R1; PIK3R2; PIK3R4; SHC1; SOS1; THEM4; TLR9; TRIB3"
"R-HSA-1296072","Voltage gated Potassium channels",0.511556782639373,0.210742020835128,0.0152071600775902,35,"KCNA1; KCNA2; KCNA3; KCNA4; KCNA7; KCNAB1; KCNAB2; KCNAB3; KCNB1; KCNB2; KCNC1; KCNC2; KCNC3; KCNC4; KCND3; KCNF1; KCNG1; KCNG2; KCNG4; KCNH1; KCNH2; KCNH3; KCNH4; KCNH5; KCNH6; KCNH7; KCNQ1; KCNQ2; KCNQ3; KCNQ4; KCNQ5; KCNS1; KCNS2; KCNS3; KCNV2"
"R-HSA-69563","p53-Dependent G1 DNA Damage Response",0.421490292363459,0.175848604782117,0.0165347507281439,54,"ATM; CCNA1; CCNA2; CCNE1; CCNE2; CDK2; CDKN1B; CDKN2A; CHEK2; MDM2; MDM4; PCBP4; PHF20; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; RFWD2; SEM1; UBA52; UBC; ZNF385A"
"R-HSA-69580","p53-Dependent G1/S DNA damage checkpoint",0.421490292363459,0.175848604782117,0.0165347507281439,54,"ATM; CCNA1; CCNA2; CCNE1; CCNE2; CDK2; CDKN1B; CDKN2A; CHEK2; MDM2; MDM4; PCBP4; PHF20; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; RFWD2; SEM1; UBA52; UBC; ZNF385A"
"R-HSA-69202","Cyclin E associated events during G1/S transition ",0.402487564419414,0.167970385117763,0.0165668751054543,60,"AKT1; AKT2; AKT3; CCNA1; CCNA2; CCND1; CCNE1; CCNE2; CCNH; CDC25A; CDK2; CDK4; CDK7; CDKN1B; CUL1; E2F1; E2F4; E2F5; LIN37; LIN52; LIN54; LIN9; MAX; MNAT1; MYC; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSMF1"
"R-HSA-176408","Regulation of APC/C activators between G1/S and early anaphase",0.407279592610058,0.170535732399791,0.0169294619161473,58,"ANAPC1; ANAPC10; ANAPC11; ANAPC15; ANAPC16; ANAPC2; ANAPC4; ANAPC5; ANAPC7; BTRC; BUB1B; BUB3; CCNA1; CCNA2; CCNB1; CDC16; CDC26; CDC27; CDK1; CDK2; CUL1; FBXO5; FZR1; MAD2L1; PLK1; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2"
"R-HSA-74751","Insulin receptor signalling cascade",0.465774462279148,0.19600070658349,0.0174828903256128,42,"AKT2; FGF1; FGF10; FGF17; FGF18; FGF2; FGF20; FGF22; FGF5; FGF7; FGF9; FGFR1; FGFR2; FGFR3; FGFR4; FRS2; GAB1; GRB10; GRB2; HRAS; INSR; IRS1; IRS2; KL; KLB; KRAS; MAPK1; MAPK3; NRAS; PDE3B; PDPK1; PIK3C3; PIK3CA; PIK3CB; PIK3R1; PIK3R2; PIK3R4; SHC1; SOS1; THEM4; TLR9; TRIB3"
"R-HSA-8963889","Assembly of active LPL and LIPC lipase complexes",-0.736929139921337,0.313448117548103,0.0187210087655762,12,"ANGPTL3; ANGPTL4; ANGPTL8; CIDEC; FURIN; LIPC; LMF1; LMF2; LPL; MBTPS1; PCSK5; PCSK6"
"R-HSA-73864","RNA Polymerase I Transcription",0.439577631789808,0.187143015253371,0.0188296645750587,47,"CBX3; CCNH; CDK7; CHD3; CHD4; EHMT2; ERCC3; ERCC6; GATAD2A; GATAD2B; GTF2H1; GTF2H2; GTF2H3; GTF2H4; GTF2H5; H2AFJ; H2AFV; H2AFX; H2AFZ; H2BFS; H3F3A; HDAC1; HDAC2; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HIST2H2AA3; HIST2H2AC; KAT2A; KAT2B; MAPK3; MBD2; MBD3; MNAT1; MTA2; MTA3; POLR1A; POLR1B; POLR1C; POLR1D; POLR1E; POLR2E; POLR2F; POLR2H; POLR2K; POLR2L"
"R-HSA-112399","IRS-mediated signalling",0.48591027207872,0.207074287829336,0.0189480986864099,37,"AKT2; FGF1; FGF10; FGF17; FGF18; FGF2; FGF20; FGF22; FGF5; FGF7; FGF9; FGFR1; FGFR2; FGFR3; FGFR4; FRS2; GAB1; GRB2; HRAS; IRS1; IRS2; KL; KLB; KRAS; NRAS; PDE3B; PDPK1; PIK3C3; PIK3CA; PIK3CB; PIK3R1; PIK3R2; PIK3R4; SOS1; THEM4; TLR9; TRIB3"
"R-HSA-3214815","HDACs deacetylate histones",0.501886402869946,0.214561253902865,0.0193287698942955,34,"ARID4A; ARID4B; BRMS1; CHD3; CHD4; GATAD2A; GATAD2B; GPS2; HDAC1; HDAC10; HDAC2; HDAC3; HIST1H2AG; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HIST2H2AA3; HIST2H2AC; HIST2H2BF; HIST3H2A; KDM1A; MBD3; MTA2; MTA3; NCOR1; PHF21A; RBBP4; REST; SAP18; SAP30; SAP30L; SUDS3; TBL1XR1"
"R-HSA-15869","Metabolism of nucleotides",0.382786872066517,0.164950702491064,0.0203076981815975,63,"ADA; ADAL; ADK; ADPRM; ADSL; ADSS; ADSSL1; AK1; AK2; AK4; AK5; AK6; AK7; AK8; AK9; AMPD1; AMPD2; AMPD3; APRT; ATIC; CAD; CDA; CMPK1; CTPS1; DCK; DCTD; DCTPP1; DGUOK; DHODH; DNPH1; DPYD; DPYS; DTYMK; DUT; ENTPD1; ENTPD2; ENTPD3; ENTPD4; ENTPD5; ENTPD6; ENTPD7; ENTPD8; GDA; GLRX; GMPR; GMPR2; GMPS; GPX1; GSR; GUK1; IMPDH1; IMPDH2; ITPA; LHPP; NME1; NME2; NME3; NME4; NME6; NME7; NT5C; NT5C1A; NT5C1B"
"R-HSA-73854","RNA Polymerase I Promoter Clearance",0.434106230751843,0.187481021199692,0.0205873555581796,47,"CCNH; CDK7; CHD3; CHD4; EHMT2; ERCC3; ERCC6; GATAD2A; GATAD2B; GTF2H1; GTF2H2; GTF2H3; GTF2H4; GTF2H5; H2AFJ; H2AFV; H2AFX; H2AFZ; H2BFS; H3F3A; HDAC1; HDAC2; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HIST2H2AA3; HIST2H2AC; KAT2A; KAT2B; MAPK3; MBD2; MBD3; MNAT1; MTA2; MTA3; POLR1A; POLR1B; POLR1C; POLR1D; POLR1E; POLR2E; POLR2F; POLR2H; POLR2K; POLR2L; RBBP4"
"R-HSA-69166","Removal of the Flap Intermediate",-0.748452914013578,0.324081661552265,0.0209181920337385,11,"DNA2; PCNA; POLA2; POLD1; POLD2; POLD3; PRIM1; PRIM2; RPA1; RPA2; RPA3"
"R-HSA-174143","APC/C-mediated degradation of cell cycle proteins",0.391740384238384,0.1698991821637,0.0211261374001574,59,"ANAPC1; ANAPC10; ANAPC11; ANAPC15; ANAPC16; ANAPC2; ANAPC4; ANAPC5; ANAPC7; AURKA; AURKB; BTRC; BUB1B; BUB3; CCNA1; CCNA2; CCNB1; CDC14A; CDC16; CDC26; CDC27; CDK1; CDK2; CUL1; FBXO5; FZR1; MAD2L1; NEK2; PLK1; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7"
"R-HSA-453276","Regulation of mitotic cell cycle",0.391740384238384,0.1698991821637,0.0211261374001574,59,"ANAPC1; ANAPC10; ANAPC11; ANAPC15; ANAPC16; ANAPC2; ANAPC4; ANAPC5; ANAPC7; AURKA; AURKB; BTRC; BUB1B; BUB3; CCNA1; CCNA2; CCNB1; CDC14A; CDC16; CDC26; CDC27; CDK1; CDK2; CUL1; FBXO5; FZR1; MAD2L1; NEK2; PLK1; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7"
"R-HSA-8978868","Fatty acid metabolism",0.388063534691072,0.168686052492981,0.021419482934255,60,"ABCC1; ACAA1; ACAA2; ACAD10; ACAD11; ACADL; ACADM; ACADS; ACADVL; ACBD4; ACBD5; ACBD7; ACLY; ACOT1; ACOT11; ACOT12; ACOT13; ACOT2; ACOT4; ACOT6; ACOT7; ACOT8; ACOX1; ACOX2; ACOX3; ACSBG1; ACSBG2; ACSF2; ACSF3; ACSL1; ACSL3; ACSL5; ACSL6; ACSM3; ACSM6; AKR1C3; ALDH3A2; ALOX12; ALOX12B; ALOX15; ALOX15B; ALOX5; ALOX5AP; ALOXE3; AMACR; CBR1; CBR4; CPT1A; CPT1B; CPT2; CRAT; CROT; CYP1A1; CYP1A2; CYP1B1; CYP2C19; CYP2C8; CYP2C9; CYP2J2; CYP2U1"
"R-HSA-1236974","ER-Phagosome pathway",0.400632264652784,0.175396676951901,0.0223627353407241,55,"B2M; CALR; CD14; CD36; CHUK; HLA-A; HLA-B; HLA-C; HLA-E; HLA-F; HLA-G; IKBKB; LY96; MYD88; PDIA3; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; SEC61A1; SEC61A2; SEC61B; SEC61G"
"R-HSA-977606","Regulation of Complement cascade",0.474493132795455,0.207941877268153,0.0224979249545142,37,"C1QA; C1QB; C1QC; C1S; C2; C3; C4A; C4B; C4BPA; C4BPB; C5; C5AR1; C5AR2; C6; C7; C8A; C8B; C8G; C9; CD19; CD46; CD55; CD59; CD81; CFB; CFH; CFHR1; CFHR3; CFHR4; CFI; CLU; CPN1; CPN2; CR1; CR2; ELANE; F2"
"R-HSA-3247509","Chromatin modifying enzymes",0.409515368980119,0.17980504895021,0.0227532764369748,52,"ACTL6A; AEBP2; ARID1B; ARID2; ARID4A; ARID4B; ARID5B; ATF2; ATF7IP; ATXN7; ATXN7L3; BRD8; BRMS1; BRPF3; BRWD1; CARM1; CCND1; CDK4; CHD3; CHD4; CLOCK; COPRS; DMAP1; DNMT3A; DOT1L; DPY30; DR1; EED; EHMT1; EHMT2; ELP2; ELP3; ELP4; ELP5; ELP6; EP300; EP400; EPC1; EZH2; GATAD2A; GATAD2B; GPS2; H2AFJ; H2AFV; H2AFX; H2AFZ; HAT1; HDAC1; HDAC10; HDAC2; HDAC3; HIST1H2AG"
"R-HSA-4839726","Chromatin organization",0.409515368980119,0.17980504895021,0.0227532764369748,52,"ACTL6A; AEBP2; ARID1B; ARID2; ARID4A; ARID4B; ARID5B; ATF2; ATF7IP; ATXN7; ATXN7L3; BRD8; BRMS1; BRPF3; BRWD1; CARM1; CCND1; CDK4; CHD3; CHD4; CLOCK; COPRS; DMAP1; DNMT3A; DOT1L; DPY30; DR1; EED; EHMT1; EHMT2; ELP2; ELP3; ELP4; ELP5; ELP6; EP300; EP400; EPC1; EZH2; GATAD2A; GATAD2B; GPS2; H2AFJ; H2AFV; H2AFX; H2AFZ; HAT1; HDAC1; HDAC10; HDAC2; HDAC3; HIST1H2AG"
"R-HSA-193807","Synthesis of bile acids and bile salts via 27-hydroxycholesterol",-0.695666269132756,0.310442716180764,0.0250335578703147,13,"AKR1C1; AKR1C2; AKR1C3; CYP27A1; CYP7A1; CYP7B1; CYP8B1; HSD3B7; NCOA1; NCOA2; NR1H4; PTGIS; RXRA"
"R-HSA-1592389","Activation of Matrix Metalloproteinases",-0.52704042357636,0.235196257422729,0.0250355476956569,28,"CMA1; COL18A1; CTRB1; CTRB2; CTSG; CTSK; CTSV; ELANE; FURIN; KLK2; KLKB1; MMP1; MMP10; MMP11; MMP14; MMP15; MMP16; MMP17; MMP2; MMP24; MMP25; MMP3; MMP7; MMP9; PLG; SPOCK3; TIMP2; TPSAB1"
"R-HSA-389357","CD28 dependent PI3K/Akt signaling",0.592211943716877,0.268118148651805,0.027190481652291,20,"AKT1; AKT2; AKT3; CD28; CD80; CD86; FYN; MAP3K8; MAPKAP1; MLST8; MTOR; PDPK1; PIK3CA; PIK3R1; PIK3R2; PIK3R3; PRR5; RICTOR; THEM4; TRIB3"
"R-HSA-110314","Recognition of DNA damage by PCNA-containing replication complex",-0.543425993832745,0.246683979717972,0.0276001244520405,25,"CUL4A; DDB1; DTL; PCNA; POLD1; POLD2; POLD3; POLE; POLE2; POLE3; POLE4; RAD18; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3; UBA52; UBC; USP1; WDR48; ZBTB32"
"R-HSA-167152","Formation of HIV elongation complex in the absence of HIV Tat",0.440441406089232,0.200074473683714,0.0277086170682157,41,"CCNH; CCNK; CCNT1; CCNT2; CDK7; CDK9; CTDP1; ELL; ELOA; ELOC; ERCC3; GTF2F1; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; GTF2H5; MNAT1; NCBP1; NCBP2; NELFA; NELFB; NELFCD; NELFE; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; SSRP1; SUPT16H; SUPT4H1; SUPT5H; TCEA1"
"R-HSA-420499","Class C/3 (Metabotropic glutamate/pheromone receptors)",-0.52555294892698,0.239578493706336,0.0282601045977999,27,"CASR; GABBR1; GABBR2; GRM1; GRM2; GRM3; GRM4; GRM5; GRM6; GRM7; GRM8; TAS1R1; TAS1R3; TAS2R10; TAS2R13; TAS2R14; TAS2R19; TAS2R20; TAS2R3; TAS2R30; TAS2R31; TAS2R4; TAS2R43; TAS2R46; TAS2R5; TAS2R50; TAS2R60"
"R-HSA-187577","SCF(Skp2)-mediated degradation of p27/p21",0.40174897089401,0.183740660275416,0.0287790378461663,50,"CCNA1; CCNA2; CCND1; CCNE1; CCNE2; CDK2; CDK4; CDKN1B; CUL1; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSMF1; PTK6; SEM1; SKP1; SKP2; UBA52; UBC"
"R-HSA-5339562","Uptake and actions of bacterial toxins",-0.523246604136369,0.239831461735426,0.0291297397716492,27,"ANTXR1; ANTXR2; CALM1; CD9; EEF2; FURIN; GUCY2C; HSP90AA1; HSP90AB1; MAP2K1; MAP2K2; MAP2K3; MAP2K4; MAP2K6; MAP2K7; PDCD6IP; PDZD3; SNAP25; STX1A; STX1B; SV2A; SV2B; SV2C; SYT1; TXNRD1; VAMP1; VAMP2"
"R-HSA-5658442","Regulation of RAS by GAPs",0.38141760554738,0.174828829228045,0.0291344061618681,56,"CUL3; DAB2IP; HRAS; KBTBD7; KRAS; NF1; NRAS; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; RASA1; RASA2; RASA3; RASA4; RASAL1; RASAL2; RASAL3; SEM1; SPRED1; SPRED2; SPRED3; UBA52; UBC"
"R-HSA-186712","Regulation of beta-cell development",0.58600322896463,0.268882109000731,0.0293015353500951,20,"AKT1; AKT2; AKT3; FGF10; FOXO1; GCK; HES1; HNF1A; HNF4G; INSM1; MAFA; NEUROD1; NKX6-1; NOTCH1; NR5A2; PAX6; PDX1; PKLR; PTF1A; RBPJ"
"R-HSA-390471","Association of TriC/CCT with target proteins during biosynthesis",0.477718356498093,0.219721747943087,0.0296903465665161,33,"AP3M1; ARFGEF2; CCNE1; CCNE2; CCT2; CCT3; CCT4; CCT5; CCT6A; CCT6B; CCT7; CCT8; DCAF7; FBXL3; FBXL5; FBXO6; FBXW10; FBXW2; FBXW5; FBXW7; FBXW9; FKBP9; GBA; HDAC3; KIF13A; KIFC3; LONP2; NOP56; SKIV2L; SPHK1; STAT3; TCP1; XRN2"
"R-HSA-163841","Gamma carboxylation, hypusine formation and arylsulfatase activation",0.481278694615442,0.222782245659344,0.0307486857761335,32,"ARSA; ARSB; ARSG; ARSI; ARSJ; ARSK; BGLAP; DHPS; DNAJC24; DOHH; DPH1; DPH2; DPH3; DPH6; DPH7; EEF2; EIF5A; EIF5A2; F10; F2; F7; FN3K; FN3KRP; FURIN; GAS6; GGCX; ICMT; PROC; PROS1; PROZ; SUMF1; SUMF2"
"R-HSA-1168372","Downstream signaling events of B Cell Receptor (BCR)",0.37207974366671,0.172300365921707,0.0308127001631831,58,"BCL10; BTRC; CALM1; CARD11; CHUK; CUL1; FBXW11; FKBP1A; HRAS; IKBKB; KRAS; MALT1; MAP3K7; NFATC1; NFATC3; NFKB1; NFKBIA; NFKBIB; NFKBIE; NRAS; PPIA; PPP3CA; PPP3CB; PPP3R1; PRKCB; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2"
"R-HSA-5610785","GLI3 is processed to GLI3R by the proteasome",0.406892304962236,0.189117361585227,0.0314341287376358,47,"BTRC; CSNK1A1; CUL1; GLI3; GSK3B; PRKACB; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; SEM1; SKP1; SUFU; UBA52; UBC"
"R-HSA-6782315","tRNA modification in the nucleus and cytosol",-0.433825937330256,0.202588380668235,0.0322405306317544,41,"ADAT1; ADAT2; ADAT3; ALKBH8; CDKAL1; CTU1; CTU2; DUS2; EPRS; KIAA1456; LCMT2; METTL1; NSUN2; NSUN6; OSGEP; PUS1; PUS3; PUS7; QTRT1; QTRT2; THADA; THG1L; TP53RK; TPRKB; TRDMT1; TRIT1; TRMT1; TRMT10A; TRMT11; TRMT112; TRMT12; TRMT13; TRMT44; TRMT5; TRMT6; TRMT61A; TYW1; TYW3; TYW5; URM1; WDR4"
"R-HSA-69017","CDK-mediated phosphorylation and removal of Cdc6",0.428751274884791,0.200854913629701,0.032791102242879,41,"CDC6; CDK2; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; SEM1; UBA52; UBC"
"R-HSA-210991","Basigin interactions",-0.54699348566566,0.256503321966796,0.0329657159627906,23,"ATP1B1; ATP1B2; ATP1B3; BSG; CAV1; ITGA3; ITGA6; ITGB1; MAG; MMP1; PPIA; PPIL2; SLC16A1; SLC16A3; SLC16A8; SLC7A10; SLC7A11; SLC7A5; SLC7A6; SLC7A7; SLC7A8; SLC7A9; SPN"
"R-HSA-109704","PI3K Cascade",0.469489506656987,0.22038412218366,0.0331449026783094,33,"AKT2; FGF1; FGF10; FGF17; FGF18; FGF2; FGF20; FGF22; FGF5; FGF7; FGF9; FGFR1; FGFR2; FGFR3; FGFR4; FRS2; GAB1; GRB2; IRS1; IRS2; KL; KLB; PDE3B; PDPK1; PIK3C3; PIK3CA; PIK3CB; PIK3R1; PIK3R2; PIK3R4; THEM4; TLR9; TRIB3"
"R-HSA-8963899","Plasma lipoprotein remodeling",-0.545538887299297,0.256685983308345,0.033560234594807,23,"ABCG1; ALB; ANGPTL3; ANGPTL4; ANGPTL8; APOA1; APOA2; APOB; APOC3; CETP; CIDEC; FURIN; LCAT; LIPC; LIPG; LMF1; LMF2; LPA; LPL; MBTPS1; PCSK5; PCSK6; PLTP"
"R-HSA-5358565","Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)",-0.668028928697821,0.316222141080046,0.0346409698141875,13,"EXO1; LIG1; MLH1; MSH2; MSH6; PCNA; PMS2; POLD1; POLD2; POLD3; RPA1; RPA2; RPA3"
"R-HSA-3371568","Attenuation phase",0.581502425966819,0.27632949154171,0.0353452588080921,19,"CRYBA4; DNAJB1; DNAJB6; EP300; FKBP4; HSBP1; HSF1; HSP90AA1; HSP90AB1; HSPA1B; HSPA1L; HSPA2; HSPA6; HSPA8; HSPH1; MRPL18; RLN1; SERPINH1; TNFRSF21"
"R-HSA-5250913","Positive epigenetic regulation of rRNA expression",0.402569963740582,0.19138500770314,0.035425918084166,46,"BAZ1B; CBX3; CHD3; CHD4; DDX21; DEK; EHMT2; EP300; ERCC6; GATAD2A; GATAD2B; GSK3B; H2AFJ; H2AFV; H2AFX; H2AFZ; H2BFS; H3F3A; HDAC1; HDAC2; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HIST2H2AA3; HIST2H2AC; KAT2A; KAT2B; MBD3; MTA2; MTA3; MYBBP1A; MYO1C; POLR1A; POLR1B; POLR1C; POLR1D; POLR1E; POLR2E; POLR2F; POLR2H; POLR2K; POLR2L; RBBP4; SF3B1; SMARCA5"
"R-HSA-73980","RNA Polymerase III Transcription Termination",0.547258971235412,0.260966245919794,0.0359892494166598,22,"CRCP; NFIA; NFIB; NFIC; NFIX; POLR1C; POLR1D; POLR2E; POLR2F; POLR2H; POLR2K; POLR2L; POLR3A; POLR3B; POLR3C; POLR3D; POLR3F; POLR3G; POLR3GL; POLR3H; POLR3K; SSB"
"R-HSA-195253","Degradation of beta-catenin by the destruction complex",0.359023638786995,0.171478474231986,0.0362871509980793,59,"AES; APC; AXIN1; AXIN2; BTRC; CSNK1A1; CTBP1; CTBP2; CTNNB1; CUL1; FRAT1; FRAT2; GSK3B; HDAC1; LEF1; MYC; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5A; PPP2R5B; PPP2R5C; PPP2R5D; PPP2R5E; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3"
"R-HSA-5357786","TNFR1-induced proapoptotic signaling",-0.723183179463365,0.345718140151667,0.0364538286239841,10,"CASP8; CYLD; FADD; RIPK1; TNF; TNFAIP3; TNFRSF1A; TRAF2; USP2; USP4"
"R-HSA-888590","GABA synthesis, release, reuptake and degradation",-0.616990261690182,0.294983369904322,0.0364733883081113,16,"ABAT; ALDH5A1; CPLX1; GAD1; HSPA8; RAB3A; RIMS1; SLC6A1; SLC6A11; SLC6A12; SLC6A13; SNAP25; STX1A; STXBP1; SYT1; VAMP2"
"R-HSA-176814","Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins",0.361330434837011,0.172815677160083,0.0365421473638262,58,"ANAPC1; ANAPC10; ANAPC11; ANAPC15; ANAPC16; ANAPC2; ANAPC4; ANAPC5; ANAPC7; BUB1B; BUB3; CCNA1; CCNA2; CCNB1; CDC16; CDC26; CDC27; CDK1; MAD2L1; NEK2; PLK1; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; PTTG1"
"R-HSA-112382","Formation of RNA Pol II elongation complex ",0.374347404855579,0.180001252923709,0.037553670398194,53,"AFF4; CCNH; CCNK; CCNT1; CCNT2; CDC73; CDK7; CDK9; CTDP1; CTR9; EAF1; EAF2; ELL; ELOA; ELOC; ERCC3; GTF2F1; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; GTF2H5; IWS1; LEO1; MLLT3; MNAT1; NCBP1; NCBP2; NELFA; NELFB; NELFCD; NELFE; PAF1; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; RTF1; SSRP1; SUPT16H; SUPT4H1; SUPT5H; SUPT6H; TCEA1; WDR61"
"R-HSA-75955","RNA Polymerase II Transcription Elongation",0.374347404855579,0.180001252923709,0.037553670398194,53,"AFF4; CCNH; CCNK; CCNT1; CCNT2; CDC73; CDK7; CDK9; CTDP1; CTR9; EAF1; EAF2; ELL; ELOA; ELOC; ERCC3; GTF2F1; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; GTF2H5; IWS1; LEO1; MLLT3; MNAT1; NCBP1; NCBP2; NELFA; NELFB; NELFCD; NELFE; PAF1; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; RTF1; SSRP1; SUPT16H; SUPT4H1; SUPT5H; SUPT6H; TCEA1; WDR61"
"R-HSA-202430","Translocation of ZAP-70 to Immunological synapse",0.630731116501254,0.303304693194929,0.037568691249495,15,"CD247; CD3D; CD3E; CD4; HLA-DPA1; HLA-DPB1; HLA-DQA1; HLA-DQA2; HLA-DQB1; HLA-DQB2; HLA-DRA; HLA-DRB1; HLA-DRB5; PTPN22; ZAP70"
"R-HSA-5655291","Signaling by FGFR4 in disease",0.706200983724833,0.339711407952278,0.0376333255622268,11,"FGFR4; FRS2; GAB1; GRB2; HRAS; KRAS; NRAS; PIK3CA; PIK3R1; PLCG1; SOS1"
"R-HSA-167172","Transcription of the HIV genome",0.360345656753768,0.174345981731371,0.0387490124479999,57,"CCNH; CCNK; CCNT1; CCNT2; CDK7; CDK9; CTDP1; ELL; ELOA; ELOC; ERCC3; GTF2A1; GTF2A2; GTF2B; GTF2E1; GTF2E2; GTF2F1; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; GTF2H5; MNAT1; NCBP1; NCBP2; NELFA; NELFB; NELFCD; NELFE; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; RNGTT; RNMT; SSRP1; SUPT16H; SUPT4H1; SUPT5H; TAF10; TAF11; TAF13; TAF2; TAF3; TAF4; TAF4B; TAF5; TAF6; TAF7"
"R-HSA-1236975","Antigen processing-Cross presentation",0.362218397613189,0.175778662044963,0.0393363899116698,56,"B2M; CALR; CD14; CD207; CD36; CHUK; CTSL; CTSS; CTSV; CYBA; FCGR1A; FCGR1B; HLA-A; HLA-B; HLA-C; HLA-E; HLA-F; HLA-G; IKBKB; ITGAV; ITGB5; LNPEP; LY96; MRC2; MYD88; NCF1; NCF2; NCF4; PDIA3; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4"
"R-HSA-69615","G1/S DNA Damage Checkpoints",0.362087016602431,0.175785034330566,0.0394149427694921,56,"ATM; CCNA1; CCNA2; CCNE1; CCNE2; CDC25A; CDK2; CDKN1B; CDKN2A; CHEK1; CHEK2; MDM2; MDM4; PCBP4; PHF20; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; RFWD2; SEM1; UBA52; UBC; ZNF385A"
"R-HSA-1362409","Mitochondrial iron-sulfur cluster biogenesis",-0.693585366332372,0.337124696974811,0.0396520375473696,11,"FDX1; FDX2; FDXR; FXN; GLRX5; HSCB; ISCA2; ISCU; LYRM4; NFS1; SLC25A37"
"R-HSA-68949","Orc1 removal from chromatin",0.357860494437652,0.174464483444367,0.0402480620062873,57,"CCNA1; CCNA2; CDC6; CDK2; CDKN1B; CDT1; FZR1; MCM2; MCM3; MCM4; MCM5; MCM6; MCM7; MCM8; ORC1; ORC3; ORC4; ORC5; ORC6; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; RB1; SEM1"
"R-HSA-69052","Switching of origins to a post-replicative state",0.357860494437652,0.174464483444367,0.0402480620062873,57,"CCNA1; CCNA2; CDC6; CDK2; CDKN1B; CDT1; FZR1; MCM2; MCM3; MCM4; MCM5; MCM6; MCM7; MCM8; ORC1; ORC3; ORC4; ORC5; ORC6; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; RB1; SEM1"
"R-HSA-190236","Signaling by FGFR",0.355773670596147,0.174563508804078,0.041542348480258,57,"BRAF; CBL; ESRP1; ESRP2; FGF1; FGF10; FGF17; FGF18; FGF2; FGF20; FGF22; FGF5; FGF7; FGF9; FGFBP1; FGFBP2; FGFBP3; FGFR1; FGFR2; FGFR3; FGFR4; FGFRL1; FLRT1; FLRT2; FLRT3; FRS2; FRS3; GAB1; GALNT3; GRB2; GTF2F1; GTF2F2; HNRNPA1; HNRNPF; HNRNPH1; HNRNPM; HRAS; KL; KLB; KRAS; MAPK1; MAPK3; MKNK1; NCBP1; NCBP2; NRAS; PIK3CA; PIK3R1; PLCG1; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I"
"R-HSA-8852276","The role of GTSE1 in G2/M progression after G2 checkpoint",0.383437202554892,0.188500373664032,0.0419369191868832,48,"CCNB1; CCNB2; CDK1; FKBPL; GTSE1; HSP90AA1; HSP90AB1; MAPRE1; PLK1; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; SEM1; UBA52; UBC"
"R-HSA-389356","CD28 co-stimulation",0.467758473774158,0.231130510422013,0.0429922721336698,30,"AKT1; AKT2; AKT3; CD28; CD80; CD86; CDC42; FYN; GRAP2; GRB2; LYN; MAP3K8; MAPKAP1; MLST8; MTOR; PAK1; PAK2; PDPK1; PIK3CA; PIK3R1; PIK3R2; PIK3R3; PRR5; RAC1; RICTOR; SRC; THEM4; TRIB3; VAV1; YES1"
"R-HSA-5610780","Degradation of GLI1 by the proteasome",0.384954904765081,0.190379717148868,0.043172490165085,47,"BTRC; CUL1; GLI1; ITCH; NUMB; PRKACB; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; SEM1; SKP1; SUFU; UBA52; UBC"
"R-HSA-69183","Processive synthesis on the lagging strand",-0.665227765037922,0.329396872029628,0.043431878745358,12,"DNA2; LIG1; PCNA; POLA2; POLD1; POLD2; POLD3; PRIM1; PRIM2; RPA1; RPA2; RPA3"
"R-HSA-179419","APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint",0.352428343613186,0.174721330869446,0.0436863045574301,57,"ANAPC1; ANAPC10; ANAPC11; ANAPC15; ANAPC16; ANAPC2; ANAPC4; ANAPC5; ANAPC7; BUB1B; BUB3; CCNA1; CCNA2; CDC16; CDC26; CDC27; CDK1; MAD2L1; NEK2; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; SEM1; UBA52"
"R-HSA-450531","Regulation of mRNA stability by proteins that bind AU-rich elements",0.357548791358493,0.177570340304663,0.0440555975510855,55,"AKT1; ANP32A; DCP2; DIS3; EIF4G1; EXOSC1; EXOSC2; EXOSC3; EXOSC4; EXOSC5; EXOSC6; EXOSC7; EXOSC8; EXOSC9; GPRC5A; HSPA8; HSPB1; MAPK11; MAPK14; MAPKAPK2; NUP214; PABPC1; PARN; PRKCA; PRKCD; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7"
"R-HSA-5669034","TNFs bind their physiological receptors",-0.513332294716916,0.255231438167519,0.0442998573981844,24,"CD27; CD70; EDARADD; LTA; TNFRSF11B; TNFRSF14; TNFRSF17; TNFRSF18; TNFRSF1A; TNFRSF1B; TNFRSF25; TNFRSF4; TNFRSF6B; TNFRSF8; TNFRSF9; TNFSF11; TNFSF13; TNFSF13B; TNFSF14; TNFSF15; TNFSF18; TNFSF4; TNFSF8; TNFSF9"
"R-HSA-8854050","FBXL7 down-regulates AURKA during mitotic entry and in early mitosis",0.394253890220519,0.196119692354595,0.0444024280676753,44,"AURKA; CUL1; FBXL18; FBXL7; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; SEM1; SKP1; UBA52; UBC"
"R-HSA-1236978","Cross-presentation of soluble exogenous antigens (endosomes)",0.406588909747187,0.202292394639016,0.0444410276711985,41,"CD207; FCGR1A; FCGR1B; MRC2; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; SEM1"
"R-HSA-3214847","HATs acetylate histones",0.399994512650947,0.200315166534148,0.0458440990114331,42,"ACTL6A; ATF2; ATXN7; ATXN7L3; BRD8; BRPF3; CLOCK; DMAP1; DR1; ELP2; ELP3; ELP4; ELP5; ELP6; EP300; EP400; EPC1; HAT1; HIST1H2AG; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HIST2H2AA3; HIST2H2AC; HIST2H2BF; HIST3H2A; IKBKAP; ING3; ING4; ING5; JADE1; JADE2; KANSL1; KANSL2; KANSL3; KAT14; KAT2A; KAT2B; KAT5; KAT6A; KAT6B"
"R-HSA-5610783","Degradation of GLI2 by the proteasome",0.380078157255871,0.190653200070497,0.0462004106768668,47,"BTRC; CSNK1A1; CUL1; GLI2; GSK3B; PRKACB; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; SEM1; SKP1; SUFU; UBA52; UBC"
"R-HSA-201681","TCF dependent signaling in response to WNT",0.367818774610935,0.185583053524289,0.0474833643629354,50,"AKT1; AKT2; APC; AXIN1; AXIN2; BCL9; BTRC; CAV1; CBY1; CCDC88C; CDC73; CHD8; CSNK1A1; CSNK1E; CSNK1G2; CSNK2A2; CSNK2B; CTBP1; CTNNB1; CTNNBIP1; CUL3; CXXC4; DACT1; DKK1; DKK4; DVL1; DVL2; DVL3; EP300; FRAT1; FRAT2; FZD1; FZD2; FZD4; FZD5; FZD6; FZD8; GSK3B; H2AFJ; H2AFV; H2AFX; H2AFZ; H2BFS; H3F3A; HDAC1; HECW1; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN"
"R-HSA-70221","Glycogen breakdown (glycogenolysis)",0.658518537840329,0.333856951864988,0.0485574412390897,12,"AGL; CALM1; GAA; GYG1; PGM1; PGM2; PGM2L1; PHKG1; PHKG2; PYGB; PYGL; PYGM"
"R-HSA-69275","G2/M Transition",0.332387983975635,0.168525083243239,0.0485713333911952,62,"ACTR1A; AJUBA; AKAP9; ALMS1; AURKA; BORA; BTRC; CCNA1; CCNA2; CCNB1; CCNB2; CCNH; CCP110; CDC25A; CDC25B; CDK1; CDK11A; CDK11B; CDK2; CDK5RAP2; CDK7; CENPF; CENPJ; CEP131; CEP135; CEP152; CEP164; CEP192; CEP250; CEP290; CEP41; CEP57; CEP63; CEP70; CEP72; CEP76; CEP78; CKAP5; CLASP1; CNTRL; CSNK1D; CSNK1E; CUL1; DCTN1; DCTN2; DYNC1H1; DYNC1I2; DYNLL1; EP300; FBXL18; FBXL7; FBXW11; FGFR1OP; FKBPL; FOXM1; GTSE1; HAUS1; HAUS2; HAUS4; HAUS5; HAUS6; HAUS8"
"R-HSA-71387","Metabolism of carbohydrates",-0.333274991429386,0.168992836611863,0.0485953430636794,63,"ABCC5; ACAN; ADPGK; AGL; AGRN; AKR1A1; AKR1B1; ALDH1A1; ALDOB; ALDOC; ARSB; B3GALT6; B3GAT1; B3GAT2; B3GAT3; B3GNT2; B3GNT3; B3GNT4; B3GNT7; B4GALT1; B4GALT2; B4GALT3; B4GALT4; B4GALT5; B4GALT6; B4GALT7; B4GAT1; BCAN; BPGM; CALM1; CD44; CEMIP; CHP1; CHPF; CHPF2; CHST1; CHST11; CHST12; CHST13; CHST15; CHST2; CHST3; CHST5; CHST6; CHST9; CHSY1; CHSY3; CRYL1; CSGALNACT1; CSGALNACT2; CSPG4; CSPG5; DCN; DCXR; DERA; DSE; DSEL; ENO1; ENO2; ENO3; EPM2A; EXT1; EXT2"
"R-HSA-69656","Cyclin A:Cdk2-associated events at S phase entry",0.336546444468959,0.171082749409202,0.0491652372974969,60,"CCNA1; CCNA2; CCND1; CCNE1; CCNE2; CCNH; CDC25A; CDC25B; CDK2; CDK4; CDK7; CDKN1B; CUL1; E2F1; E2F4; E2F5; FZR1; LIN37; LIN52; LIN54; LIN9; MAX; MNAT1; MYC; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSMF1; PTK6"
"R-HSA-5693571","Nonhomologous End-Joining (NHEJ)",0.417136840976599,0.212080559440712,0.0491971390885429,37,"ATM; BABAM1; BARD1; BRCA1; DCLRE1C; FAM175A; H2AFX; H2BFS; HERC2; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; KAT5; LIG4; MDC1; MRE11; NBN; NHEJ1; PAXIP1; PIAS4; POLL; POLM; PRKDC; RAD50; RIF1; RNF168; RNF8; SUMO1; TDP1; TDP2; TP53BP1; UBE2N; UIMC1; XRCC4; XRCC5; XRCC6"
"R-HSA-8848021","Signaling by PTK6",0.375271187696274,0.190920175750934,0.0493457482969564,47,"AKT1; ARAP1; ARHGAP35; BCAR1; BTC; CBL; CCND1; CCNE1; CDK2; CDK4; CDKN1B; CRK; DOCK1; DOK1; EGF; EGFR; ELMO1; ELMO2; EPAS1; ERBB2; ERBB3; ERBB4; EREG; GPNMB; HIF1A; HRAS; KHDRBS1; KHDRBS2; KHDRBS3; KRAS; LRRK2; NR3C1; NRAS; NRG1; NRG4; PELP1; PTK6; PTPN1; PXN; RAC1; RASA1; SOCS3; SRMS; STAP2; STAT3; UBA52; UBC"
"R-HSA-9006927","Signaling by Non-Receptor Tyrosine Kinases",0.375271187696274,0.190920175750934,0.0493457482969564,47,"AKT1; ARAP1; ARHGAP35; BCAR1; BTC; CBL; CCND1; CCNE1; CDK2; CDK4; CDKN1B; CRK; DOCK1; DOK1; EGF; EGFR; ELMO1; ELMO2; EPAS1; ERBB2; ERBB3; ERBB4; EREG; GPNMB; HIF1A; HRAS; KHDRBS1; KHDRBS2; KHDRBS3; KRAS; LRRK2; NR3C1; NRAS; NRG1; NRG4; PELP1; PTK6; PTPN1; PXN; RAC1; RASA1; SOCS3; SRMS; STAP2; STAT3; UBA52; UBC"
"R-HSA-606279","Deposition of new CENPA-containing nucleosomes at the centromere",-0.436168320972838,0.221920275462865,0.0493647225383415,34,"CENPA; CENPC; CENPH; CENPK; CENPL; CENPM; CENPN; CENPO; CENPP; CENPQ; CENPT; CENPU; CENPW; H2AFJ; H2AFV; H2AFX; H2AFZ; H2BFS; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HIST2H2AA3; HIST2H2AC; HJURP; ITGB3BP; MIS18A; MIS18BP1; NPM1; OIP5; RBBP4; RSF1; RUVBL1; SMARCA5"
"R-HSA-774815","Nucleosome assembly",-0.436168320972838,0.221920275462865,0.0493647225383415,34,"CENPA; CENPC; CENPH; CENPK; CENPL; CENPM; CENPN; CENPO; CENPP; CENPQ; CENPT; CENPU; CENPW; H2AFJ; H2AFV; H2AFX; H2AFZ; H2BFS; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HIST2H2AA3; HIST2H2AC; HJURP; ITGB3BP; MIS18A; MIS18BP1; NPM1; OIP5; RBBP4; RSF1; RUVBL1; SMARCA5"
"R-HSA-937041","IKK complex recruitment mediated by RIP1",0.549566052498244,0.28027959965254,0.0499049339658915,19,"BIRC2; BIRC3; CD14; CHUK; IKBKB; LY96; RIPK1; RIPK3; SARM1; TICAM1; TICAM2; TLR4; TRAF6; UBA52; UBC; UBE2D1; UBE2D3; UBE2N; UBE2V1"
"R-HSA-5621575","CD209 (DC-SIGN) signaling",0.587081283723422,0.300010896054756,0.0503631615414697,16,"CD209; EP300; FYN; HRAS; ICAM2; ICAM3; KRAS; LYN; NFKB1; NRAS; PAK1; PAK2; PRKACB; RAF1; RELA; RPS6KA5"
"R-HSA-69300","Removal of licensing factors from origins",0.339874986483847,0.173809750353122,0.0505308546089709,58,"CCNA1; CCNA2; CDC6; CDK2; CDKN1B; CDT1; FZR1; GMNN; MCM10; MCM2; MCM3; MCM4; MCM5; MCM6; MCM7; MCM8; ORC1; ORC3; ORC4; ORC5; ORC6; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; RB1"
"R-HSA-174184","Cdc20:Phospho-APC/C mediated degradation of Cyclin A",0.344940126709807,0.176601491260094,0.0507944966625824,56,"ANAPC1; ANAPC10; ANAPC11; ANAPC15; ANAPC16; ANAPC2; ANAPC4; ANAPC5; ANAPC7; BUB1B; BUB3; CCNA1; CCNA2; CDC16; CDC26; CDC27; CDK1; MAD2L1; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; SEM1; UBA52"
"R-HSA-3371571","HSF1-dependent transactivation",0.455434234499419,0.236077989945787,0.0537099406331734,29,"AKT1S1; CAMK2A; CAMK2B; CAMK2D; CAMK2G; CRYAB; CRYBA4; DNAJB1; DNAJB6; EP300; FKBP4; HSBP1; HSF1; HSP90AA1; HSP90AB1; HSPA1B; HSPA1L; HSPA2; HSPA6; HSPA8; HSPB8; HSPH1; MLST8; MRPL18; MTOR; RLN1; RPTOR; SERPINH1; TNFRSF21"
"R-HSA-176409","APC/C:Cdc20 mediated degradation of mitotic proteins",0.338152324426833,0.175381909622975,0.0538437778087458,57,"ANAPC1; ANAPC10; ANAPC11; ANAPC15; ANAPC16; ANAPC2; ANAPC4; ANAPC5; ANAPC7; BUB1B; BUB3; CCNA1; CCNA2; CCNB1; CDC16; CDC26; CDC27; CDK1; MAD2L1; NEK2; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; PTTG1"
"R-HSA-6807070","PTEN Regulation",0.368594639060372,0.191286671552364,0.0539892579207482,47,"AGO1; AGO2; AGO3; AGO4; AKT1; AKT2; AKT3; ATF2; ATN1; BMI1; CBX2; CBX4; CBX6; CBX8; CHD3; CHD4; CNOT6L; CSNK2A2; CSNK2B; EED; EGR1; EZH2; FRK; GATAD2A; GATAD2B; HDAC1; HDAC2; HDAC3; HDAC5; HDAC7; KDM1A; LAMTOR2; LAMTOR3; LAMTOR4; LAMTOR5; MAF1; MAPK1; MAPK3; MBD3; MECOM; MKRN1; MLST8; MOV10; MTA2; MTA3; MTOR; NEDD4"
"R-HSA-6811442","Intra-Golgi and retrograde Golgi-to-ER traffic",-0.321543891053683,0.166882210536048,0.0540081097983599,65,"ACTR10; ACTR1A; AGPAT3; ARCN1; ARF3; ARF4; ARF5; ARFGAP1; ARFGAP2; ARFGAP3; ARFIP2; ARFRP1; ARL1; BET1L; BICD1; BICD2; BNIP1; CAPZA1; CAPZA2; CAPZA3; CAPZB; CENPE; COG1; COG2; COG3; COG4; COG5; COG6; COG7; COG8; COPA; COPB1; COPB2; COPE; COPG1; COPG2; COPZ1; COPZ2; CUX1; CYTH1; CYTH2; CYTH3; CYTH4; DCTN1; DCTN2; DCTN4; DCTN5; DCTN6; DYNC1H1; DYNC1I1; DYNC1I2; DYNC1LI1; DYNC1LI2; DYNLL1; DYNLL2; GALNT1; GALNT2; GBF1; GCC1; GCC2; GOLGA1; GOLGA4; GOLGA5; GOLIM4; GOSR1"
"R-HSA-6785807","Interleukin-4 and 13 signaling",0.345370898281407,0.179782843495197,0.0547260586003557,54,"AKT1; ALOX15; ALOX5; ANXA1; BATF; BCL2; BCL2L1; BIRC5; CCL11; CCL2; CCL22; CCND1; CD36; COL1A2; CXCL8; F13A1; FASLG; FCER2; FGF2; FN1; FOS; FOXO1; FOXO3; FSCN1; GATA3; HGF; HIF1A; HMOX1; HSP90AA1; HSP90B1; HSPA8; ICAM1; IL10; IL12A; IL13; IL18; IL1A; IL1B; IL23A; IL4; IL4R; IL6R; IRF4; ITGAM; ITGAX; ITGB1; ITGB2; JAK1; JAK2; JAK3; JUNB; LAMA5; LBP; LCN2"
"R-HSA-391251","Protein folding",0.336101061079406,0.17547508645244,0.0554443576167275,57,"AP3M1; ARFGEF2; ARL2; CCNE1; CCNE2; CCT2; CCT3; CCT4; CCT5; CCT6A; CCT6B; CCT7; CCT8; CSNK2A2; CSNK2B; DCAF7; FBXL3; FBXL5; FBXO6; FBXW10; FBXW2; FBXW5; FBXW7; FBXW9; FKBP9; GBA; GNAI1; GNAI2; GNAI3; GNAO1; GNAT1; GNAT2; GNAT3; GNAZ; GNB1; GNB2; GNB3; GNB4; GNB5; GNG10; GNG11; GNG12; GNG2; GNG3; GNG4; GNG5; GNG7; GNGT2; HDAC3; KIF13A; KIFC3; LONP2; NOP56; PFDN1; PFDN5; PFDN6; RGS11"
"R-HSA-69541","Stabilization of p53",0.367624764044204,0.193379325835973,0.0572947887965179,46,"ATM; CDKN2A; CHEK2; MDM2; MDM4; PHF20; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; RFWD2; SEM1; UBA52; UBC"
"R-HSA-8878171","Transcriptional regulation by RUNX1",0.359446740378306,0.189799735545802,0.0582487624765945,48,"ABL1; ACTL6A; AGO1; AGO2; AGO3; AGO4; ARID1B; ARID2; AUTS2; AXIN1; BLK; BMI1; CBFB; CBX2; CBX4; CBX6; CBX8; CCND1; CCND2; CCND3; CCNH; CDK6; CDK7; CLDN5; CR1; CSNK2A2; CSNK2B; CTLA4; CTSK; CTSL; CTSV; DPY30; ELF1; ELF2; EP300; ESR1; GATA3; GP1BA; GPAM; H2AFJ; H2AFV; H2AFX; H2AFZ; H2BFS; H3F3A; HDAC1; HIPK2; HIST1H2BD"
"R-HSA-597592","Post-translational protein modification",-0.341231802541764,0.181944837130697,0.0607283053138074,54,"A4GNT; ACTL6A; ACTR10; ACTR1A; ACTR5; ACTR8; ADAM10; ADAMTS10; ADAMTS12; ADAMTS13; ADAMTS14; ADAMTS15; ADAMTS16; ADAMTS17; ADAMTS18; ADAMTS19; ADAMTS2; ADAMTS3; ADAMTS4; ADAMTS5; ADAMTS6; ADAMTS7; ADAMTS8; ADAMTS9; ADAMTSL1; ADAMTSL2; ADAMTSL3; ADAMTSL4; ADAMTSL5; ADRB2; ADRM1; AGBL2; AGBL3; AGBL4; AGBL5; AGTPBP1; ALB; ALG1; ALG10; ALG11; ALG12; ALG14; ALG3; ALG5; ALG6; ALG8; ALG9; ALPL; AMDHD2; AMFR; AMTN; ANK1; ANK2; ANK3"
"R-HSA-933541","TRAF6 mediated IRF7 activation",-0.568438014391792,0.303125054709647,0.0607570884509871,16,"DDX58; DHX36; EP300; IFIH1; IRF1; IRF3; IRF7; MAVS; MYD88; RNF135; SIKE1; TANK; TBK1; TRAF2; TRAF6; TRIM25"
"R-HSA-209776","Amine-derived hormones",-0.580580673611554,0.310832901717846,0.0617868224269928,15,"AANAT; CGA; DBH; DDC; DIO1; DIO2; DIO3; DUOX1; DUOX2; IYD; PNMT; TH; TPH1; TPO; TSHB"
"R-HSA-6803157","Antimicrobial peptides",-0.437960153949026,0.235873311393144,0.0633452922728451,30,"ART1; ATOX1; BPI; BPIFA1; BPIFA2; BPIFB1; BPIFB2; BPIFB4; CAMP; CCR2; CCR6; CD4; CHGA; CLU; CTSG; DCD; DEFA3; DEFA4; DEFA5; DEFB1; DEFB119; DEFB124; DEFB132; DEFB134; ELANE; GNLY; ITLN1; LCN2; LTF; LYZ"
"R-HSA-174084","Autodegradation of Cdh1 by Cdh1:APC/C",0.33745296798804,0.181825261815276,0.06346509658965,53,"ANAPC1; ANAPC10; ANAPC11; ANAPC15; ANAPC16; ANAPC2; ANAPC4; ANAPC5; ANAPC7; CDC16; CDC26; CDC27; FZR1; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSMF1; SEM1; UBA52; UBC; UBE2D1; UBE2E1"
"R-HSA-9010553","Regulation of expression of SLITs and ROBOs",0.331678649593991,0.178791120198666,0.0635793585309886,55,"CASC3; CUL2; DAG1; EIF4A3; EIF4G1; ELOC; ETF1; FAU; GSPT1; HOXA2; LDB1; LHX2; LHX4; LHX9; MAGOH; MAGOHB; MSI1; NCBP1; NCBP2; PABPC1; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4"
"R-HSA-5682910","LGI-ADAM interactions",-0.6084273118194,0.328193426094343,0.063758037695015,13,"ADAM11; ADAM22; ADAM23; CACNG3; CACNG4; CACNG8; DLG4; LGI1; LGI2; LGI3; LGI4; STX1A; STX1B"
"R-HSA-202433","Generation of second messenger molecules",0.460715470565071,0.24868971841385,0.0639438086863239,26,"CD101; CD247; CD3D; CD3E; CD4; ENAH; EVL; FYB; GRAP2; HLA-DPA1; HLA-DPB1; HLA-DQA1; HLA-DQA2; HLA-DQB1; HLA-DQB2; HLA-DRA; HLA-DRB1; HLA-DRB5; ITK; LAT; LCP2; NCK1; PAK1; PAK2; PLCG1; ZAP70"
"R-HSA-1442490","Collagen degradation",-0.413452907113425,0.223685480738821,0.064549239429637,34,"ADAM10; ADAM17; ADAM9; COL12A1; COL13A1; COL14A1; COL15A1; COL16A1; COL17A1; COL18A1; COL19A1; COL23A1; COL25A1; COL9A1; COL9A2; COL9A3; CTSB; CTSD; CTSK; CTSL; ELANE; FURIN; MMP1; MMP10; MMP11; MMP14; MMP15; MMP19; MMP2; MMP3; MMP7; MMP9; PHYKPL; TMPRSS6"
"R-HSA-174178","APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1",0.326509591690334,0.177444723902795,0.0657588887502497,56,"ANAPC1; ANAPC10; ANAPC11; ANAPC15; ANAPC16; ANAPC2; ANAPC4; ANAPC5; ANAPC7; AURKA; AURKB; CDC16; CDC26; CDC27; FZR1; PLK1; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; PTTG1; SEM1; SKP2; UBA52"
"R-HSA-3700989","Transcriptional Regulation by TP53",0.323021310238918,0.176058783852936,0.0665448816581798,57,"AGO1; AGO2; AGO3; AGO4; AIFM2; AKT1; AKT2; AKT3; APAF1; ARID3A; ATF2; ATM; ATR; ATRIP; AURKA; AURKB; BANP; BARD1; BAX; BBC3; BCL2L14; BID; BIRC5; BLM; BNIP3L; BRCA1; BRD7; BRIP1; BRPF3; CARM1; CASP1; CASP10; CASP6; CCNA1; CCNA2; CCNB1; CCNE1; CCNE2; CCNG1; CCNH; CCNK; CCNT1; CCNT2; CDK1; CDK13; CDK2; CDK5R1; CDK7; CDK9; CDKN1B; CDKN2A; CENPJ; CHD3; CHD4; CHEK1; CHEK2; CNOT1"
"R-HSA-72702","Ribosomal scanning and start codon recognition",-0.340110667597922,0.185410168228789,0.0665992358716656,52,"EIF2S1; EIF2S2; EIF3A; EIF3B; EIF3C; EIF3D; EIF3E; EIF3F; EIF3G; EIF3H; EIF3I; EIF3J; EIF3K; EIF3L; EIF3M; EIF4A1; EIF4A2; EIF4B; EIF4E; EIF4G1; EIF4H; EIF5; FAU; RPS10; RPS11; RPS12; RPS13; RPS14; RPS15; RPS15A; RPS16; RPS18; RPS19; RPS2; RPS20; RPS21; RPS23; RPS24; RPS25; RPS26; RPS27; RPS27L; RPS28; RPS29; RPS3; RPS3A; RPS5; RPS6; RPS7; RPS8; RPS9; RPSA"
"R-HSA-77588","SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs",0.664238664708636,0.364225207943608,0.0681969600304962,10,"LSM10; LSM11; NCBP1; NCBP2; SLBP; SNRPB; SNRPD3; SNRPE; SNRPF; ZNF473"
"R-HSA-181430","Norepinephrine Neurotransmitter Release Cycle",-0.543307451195191,0.298084017515259,0.0683540704356405,17,"CPLX1; PPFIA1; PPFIA2; PPFIA3; PPFIA4; RAB3A; RIMS1; SLC18A2; SLC22A1; SLC22A2; SNAP25; STX1A; STXBP1; SYT1; TSPOAP1; UNC13B; VAMP2"
"R-HSA-180585","Vif-mediated degradation of APOBEC3G",0.368259719939251,0.202221105701455,0.068595517150327,42,"APOBEC3G; CUL5; ELOC; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; SEM1; UBA52; UBC"
"R-HSA-202427","Phosphorylation of CD3 and TCR zeta chains",0.526981740140014,0.290657620808732,0.0698214884191794,18,"CD247; CD3D; CD3E; CD4; CSK; HLA-DPA1; HLA-DPB1; HLA-DQA1; HLA-DQA2; HLA-DQB1; HLA-DQB2; HLA-DRA; HLA-DRB1; HLA-DRB5; PAG1; PTPN22; PTPRC; PTPRJ"
"R-HSA-72649","Translation initiation complex formation",-0.336264984813362,0.185590939953309,0.0700076778436319,52,"EIF2S1; EIF2S2; EIF3A; EIF3B; EIF3C; EIF3D; EIF3E; EIF3F; EIF3G; EIF3H; EIF3I; EIF3J; EIF3K; EIF3L; EIF3M; EIF4A1; EIF4A2; EIF4B; EIF4E; EIF4G1; EIF4H; FAU; PABPC1; RPS10; RPS11; RPS12; RPS13; RPS14; RPS15; RPS15A; RPS16; RPS18; RPS19; RPS2; RPS20; RPS21; RPS23; RPS24; RPS25; RPS26; RPS27; RPS27L; RPS28; RPS29; RPS3; RPS3A; RPS5; RPS6; RPS7; RPS8; RPS9; RPSA"
"R-HSA-72662","Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S",-0.336264984813362,0.185590939953309,0.0700076778436319,52,"EIF2S1; EIF2S2; EIF3A; EIF3B; EIF3C; EIF3D; EIF3E; EIF3F; EIF3G; EIF3H; EIF3I; EIF3J; EIF3K; EIF3L; EIF3M; EIF4A1; EIF4A2; EIF4B; EIF4E; EIF4G1; EIF4H; FAU; PABPC1; RPS10; RPS11; RPS12; RPS13; RPS14; RPS15; RPS15A; RPS16; RPS18; RPS19; RPS2; RPS20; RPS21; RPS23; RPS24; RPS25; RPS26; RPS27; RPS27L; RPS28; RPS29; RPS3; RPS3A; RPS5; RPS6; RPS7; RPS8; RPS9; RPSA"
"R-HSA-5696398","Nucleotide Excision Repair",0.311556649417499,0.172150264597798,0.0703276184770254,60,"ACTL6A; ACTR5; ACTR8; AQR; CCNH; CDK7; CHD1L; COPS2; COPS3; COPS6; COPS7A; COPS7B; COPS8; CUL4A; DDB1; DDB2; ELL; EP300; ERCC3; ERCC4; ERCC5; ERCC6; ERCC8; GPS1; GTF2H1; GTF2H2; GTF2H3; GTF2H4; GTF2H5; HMGN1; INO80; INO80B; INO80C; INO80D; INO80E; ISY1; LIG1; LIG3; MCRS1; MNAT1; NFRKB; PARP1; PARP2; PCNA; PIAS1; PIAS3; POLD1; POLD2; POLD3; POLE; POLE2; POLE3; POLE4; POLK; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F"
"R-HSA-3134963","DEx/H-box helicases activate type I IFN and inflammatory cytokines production ",-0.633542162764772,0.350810476628935,0.070927938995284,11,"AGER; APP; DHX36; IRF7; MYD88; NFKB1; NFKB2; RELA; S100A12; S100B; SAA1"
"R-HSA-1169091","Activation of NF-kappaB in B cells",0.320885169348125,0.177694809133455,0.0709461709787493,56,"BCL10; BTRC; CARD11; CHUK; CUL1; FBXW11; IKBKB; MALT1; MAP3K7; NFKB1; NFKBIA; NFKBIB; NFKBIE; PRKCB; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; REL; RELA; SEM1; SKP1; UBA52; UBC"
"R-HSA-912631","Regulation of signaling by CBL",0.524897305024391,0.29091128254524,0.0711810163580021,18,"BLNK; CBL; CRK; CRKL; FYN; GRB2; HCK; LYN; PIK3CA; PIK3CB; PIK3CD; PIK3R1; PIK3R2; PIK3R3; RAPGEF1; SYK; VAV1; YES1"
"R-HSA-418594","G alpha (i) signalling events",-0.344021646902383,0.190725878598682,0.0712706361476293,49,"ABCA4; ACKR3; ADCY1; ADCY2; ADCY3; ADCY4; ADCY5; ADCY6; ADCY7; ADCY9; ADORA1; ADRA2A; ADRA2C; AGRN; AGT; AHCYL1; AKR1B10; AKR1C1; AKR1C3; ANXA1; APLNR; APOA1; APOA2; APOB; APOC3; APOM; APP; BCO1; BCO2; BDKRB1; BDKRB2; C3; C5; C5AR1; CALM1; CAMK4; CAMKMT; CASR; CCL13; CCL19; CCL20; CCL25; CCL27; CCL28; CCR1; CCR10; CCR2; CCR3; CCR5"
"R-HSA-157858","Gap junction trafficking and regulation",0.490634511338466,0.273302863541162,0.0726211349430155,21,"AP2M1; CLTA; CLTB; CLTC; CLTCL1; DAB2; DNM1; DNM2; GJA1; GJA3; GJA4; GJB2; GJB3; GJB4; GJB5; GJB6; GJC1; GJD2; MYO6; SRC; TJP1"
"R-HSA-983231","Factors involved in megakaryocyte development and platelet production",0.362985911592754,0.202526019808812,0.0730860882985339,42,"ABL1; AK3; AKAP1; AKAP10; CABLES1; CABLES2; CAPZA1; CAPZA2; CAPZB; CARMIL1; CBX5; CDC42; CDK2; CENPE; DOCK1; DOCK10; DOCK2; DOCK3; DOCK4; DOCK5; DOCK6; DOCK7; DOCK8; DOCK9; EHD1; EHD2; EHD3; EP300; GATA3; GATA5; H3F3A; HBB; HBG1; HBG2; HDAC1; HDAC2; IRF1; IRF3; IRF7; ITPK1; JAK2; JMJD1C"
"R-HSA-69304","Regulation of DNA replication",0.314623898750887,0.176423901119229,0.0745308825768593,57,"CCNA1; CCNA2; CDC6; CDK2; CDKN1B; CDT1; E2F1; E2F2; FZR1; GMNN; MCM10; MCM2; MCM3; MCM4; MCM5; MCM6; MCM7; MCM8; ORC1; ORC3; ORC4; ORC5; ORC6; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3"
"R-HSA-381119","Unfolded Protein Response (UPR)",0.316855912865884,0.177871855253991,0.0748517265362057,56,"ACADVL; ADD1; ARFGAP1; ASNS; ATF3; ATF4; ATF6; ATP6V0D1; CALR; CCL2; CREB3; CREB3L2; CREB3L4; CREBRF; CTDSP2; CUL7; CXCL8; CXXC1; DCP2; DCSTAMP; DCTN1; DDIT3; DDX11; DIS3; DNAJB11; DNAJB9; DNAJC3; EDEM1; EIF2AK3; EIF2S1; ERN1; EXOSC1; EXOSC2; EXOSC3; EXOSC4; EXOSC5; EXOSC6; EXOSC7; EXOSC8; EXOSC9; EXTL1; EXTL2; EXTL3; FKBP14; GFPT1; GOSR2; HDGF; HERPUD1; HSP90B1; IGFBP1; KDELR3; KLHDC3; LMNA; MBTPS1; MYDGF; NFYA"
"R-HSA-5620916","VxPx cargo-targeting to cilium",-0.532868367468134,0.299636536041133,0.075341057389802,17,"ARF4; ASAP1; CNGA4; EXOC1; EXOC2; EXOC3; EXOC4; EXOC5; EXOC6; EXOC7; GBF1; PKD1; PKD2; RAB11A; RAB11FIP3; RAB3IP; RAB8A"
"R-HSA-1234176","Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha",0.324084463390848,0.18244967187217,0.0756842857020059,53,"AJUBA; CUL2; EGLN1; EGLN2; EGLN3; ELOC; EPAS1; HIF1A; HIF3A; LIMD1; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; SEM1; UBA52; UBC; UBE2D1; UBE2D3; VHL; WTIP"
"R-HSA-390466","Chaperonin-mediated protein folding",0.313445267491782,0.176474538675168,0.0757081823074619,57,"AP3M1; ARFGEF2; CCNE1; CCNE2; CCT2; CCT3; CCT4; CCT5; CCT6A; CCT6B; CCT7; CCT8; CSNK2A2; CSNK2B; DCAF7; FBXL3; FBXL5; FBXO6; FBXW10; FBXW2; FBXW5; FBXW7; FBXW9; FKBP9; GBA; GNAI1; GNAI2; GNAI3; GNAO1; GNAT1; GNAT2; GNAT3; GNAZ; GNB1; GNB2; GNB3; GNB4; GNB5; GNG10; GNG11; GNG12; GNG2; GNG3; GNG4; GNG5; GNG7; GNGT2; HDAC3; KIF13A; KIFC3; LONP2; NOP56; PFDN1; PFDN5; PFDN6; RGS11; RGS6"
"R-HSA-3769402","Deactivation of the beta-catenin transactivating complex",0.395012293238866,0.222683914049013,0.0760846719433949,34,"AKT1; AKT2; APC; BCL9; BTRC; CBY1; CHD8; CTBP1; CTNNB1; CTNNBIP1; HDAC1; LEF1; MEN1; PYGO1; PYGO2; RBBP5; SOX13; SOX17; SOX2; SOX4; SOX6; SOX7; SOX9; TCF7; TCF7L1; TCF7L2; TLE1; TLE2; TLE3; TLE4; UBA52; UBC; XPO1; YWHAZ"
"R-HSA-1234158","Regulation of gene expression by Hypoxia-inducible Factor",-0.646567251227731,0.364552900678858,0.076131051058055,10,"ARNT; CA9; CITED2; EP300; EPAS1; EPO; HIF1A; HIF3A; HIGD1A; VEGFA"
"R-HSA-1257604","PIP3 activates AKT signaling",0.312583400255369,0.176511471734154,0.0765780532394535,57,"AGO1; AGO2; AGO3; AGO4; AKT1; AKT1S1; AKT2; AKT3; ATF2; ATN1; BAD; BMI1; BTC; CASP9; CBX2; CBX4; CBX6; CBX8; CD19; CD28; CD80; CD86; CDKN1B; CHD3; CHD4; CHUK; CNOT6L; CSNK2A2; CSNK2B; EED; EGF; EGFR; EGR1; ERBB2; ERBB3; ERBB4; EREG; ESR1; ESR2; EZH2; FGF1; FGF10; FGF17; FGF18; FGF2; FGF20; FGF22; FGF5; FGF7; FGF9; FGFR1; FGFR2; FGFR3; FGFR4; FOXO1; FOXO3; FRK"
"R-HSA-193775","Synthesis of bile acids and bile salts via 24-hydroxycholesterol",-0.605502434187484,0.341944275905509,0.0766000421390914,12,"AKR1C1; AKR1C2; AKR1C3; AMACR; CYP27A1; CYP39A1; CYP46A1; CYP8B1; HSD3B7; PTGIS; SLC27A2; SLC27A5"
"R-HSA-211976","Endogenous sterols",-0.446223595288506,0.252336872139223,0.076999968441342,26,"AHR; ARNT; ARNT2; CYP11A1; CYP11B1; CYP17A1; CYP19A1; CYP1B1; CYP21A2; CYP27A1; CYP39A1; CYP46A1; CYP4V2; CYP51A1; CYP7A1; CYP7B1; CYP8B1; FDX1; FDX2; FDXR; NCOA1; NCOA2; NR1H4; POMC; PTGIS; RXRA"
"R-HSA-211733","Regulation of activated PAK-2p34 by proteasome mediated degradation",0.366194527308313,0.207276260489074,0.0772788407739873,40,"PAK2; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; SEM1; UBA52; UBC"
"R-HSA-351202","Metabolism of polyamines",0.308980497987125,0.175157492533997,0.0777294020918689,58,"ADI1; AGMAT; AMD1; APIP; ARG1; ARG2; ASL; ASS1; AZIN1; AZIN2; CKB; CKMT1A; CKMT2; CPS1; ENOPH1; GATM; GOT1; MRI1; MTAP; NAGS; NMRAL1; NQO1; OAZ1; OAZ2; OAZ3; ODC1; PAOX; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8"
"R-HSA-422085","Synthesis, secretion, and deacylation of Ghrelin",-0.554771854655827,0.315171565831541,0.0783702104875921,15,"ACHE; BCHE; CRHR2; GCG; GHRL; IGF1; MBOAT4; PCSK1; PLA2G7; SEC11A; SEC11C; SPCS1; SPCS2; SPCS3; UCN"
"R-HSA-4641258","Degradation of DVL",0.34187916606688,0.194758789951838,0.0791912752597126,46,"CUL3; DACT1; DVL1; DVL2; DVL3; HECW1; KLHL12; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; SEM1; UBA52; UBC"
"R-HSA-167169","HIV Transcription Elongation",0.367868547647969,0.209784402907245,0.0795067392473918,39,"CCNH; CCNT1; CDK7; CDK9; CTDP1; ELL; ELOA; ELOC; ERCC3; GTF2F1; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; GTF2H5; MNAT1; NCBP1; NCBP2; NELFA; NELFB; NELFCD; NELFE; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; SSRP1; SUPT16H; SUPT4H1; SUPT5H; TCEA1"
"R-HSA-167200","Formation of HIV-1 elongation complex containing HIV-1 Tat",0.367868547647969,0.209784402907245,0.0795067392473918,39,"CCNH; CCNT1; CDK7; CDK9; CTDP1; ELL; ELOA; ELOC; ERCC3; GTF2F1; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; GTF2H5; MNAT1; NCBP1; NCBP2; NELFA; NELFB; NELFCD; NELFE; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; SSRP1; SUPT16H; SUPT4H1; SUPT5H; TCEA1"
"R-HSA-167246","Tat-mediated elongation of the HIV-1 transcript",0.367868547647969,0.209784402907245,0.0795067392473918,39,"CCNH; CCNT1; CDK7; CDK9; CTDP1; ELL; ELOA; ELOC; ERCC3; GTF2F1; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; GTF2H5; MNAT1; NCBP1; NCBP2; NELFA; NELFB; NELFCD; NELFE; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; SSRP1; SUPT16H; SUPT4H1; SUPT5H; TCEA1"
"R-HSA-392451","G beta:gamma signalling through PI3Kgamma",0.379806717415973,0.21748588518424,0.0807499594483055,36,"AKT1; AKT2; AKT3; CSF2RB; GAB2; GNB1; GNB2; GNB3; GNB4; GNB5; GNG10; GNG11; GNG12; GNG2; GNG3; GNG4; GNG5; GNG7; GNGT2; GRB2; IL2RA; IL2RB; IL5; JAK1; JAK2; JAK3; PDPK1; PIK3CA; PIK3CB; PIK3CD; PIK3CG; PIK3R1; PIK3R2; PIK3R3; PIK3R5; SHC1"
"R-HSA-5654696","Downstream signaling of activated FGFR2",0.460907244213034,0.264215374002713,0.081082805927992,23,"FGF1; FGF10; FGF17; FGF18; FGF2; FGF20; FGF22; FGF5; FGF7; FGF9; FGFR2; FRS2; FRS3; GAB1; GRB2; HRAS; KRAS; NRAS; PIK3CA; PIK3R1; PLCG1; SHC1; SOS1"
"R-HSA-1280218","Adaptive Immune System",0.302716196848486,0.173946831634437,0.0818098593997813,59,"ACTR10; ACTR1A; ACTR1B; AHCYL1; AKT1; AKT2; AKT3; ANAPC1; ANAPC10; ANAPC11; ANAPC13; ANAPC2; ANAPC4; ANAPC5; ANAPC7; AP1B1; AP1G1; AP1M1; AP1M2; AP1S1; AP1S3; AP2A1; AP2A2; AP2B1; AP2M1; AP2S1; AREL1; ARIH2; ASB1; ASB13; ASB14; ASB15; ASB16; ASB18; ASB2; ASB3; ASB4; ASB5; ASB6; ASB7; ASB8; ATG7; B2M; BCL10; BLK; BLMH; BLNK; BTBD1; BTBD6; BTN1A1; BTN2A1; BTN2A2; BTN3A1; BTN3A2; BTN3A3; BTNL2; BTNL8; BTNL9; BTRC"
"R-HSA-349425","Autodegradation of the E3 ubiquitin ligase COP1",0.356892074261319,0.205303800274395,0.0821472629586338,41,"ATM; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; RFWD2; SEM1; UBA52; UBC"
"R-HSA-5655253","Signaling by FGFR2 in disease",0.377580382840133,0.217630328254838,0.0827475090735873,36,"FGF1; FGF10; FGF17; FGF18; FGF2; FGF20; FGF22; FGF5; FGF7; FGF9; FGFR2; FRS2; GAB1; GRB2; GTF2F1; GTF2F2; HRAS; KRAS; NCBP1; NCBP2; NRAS; PIK3CA; PIK3R1; PLCG1; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; SOS1"
"R-HSA-453274","Mitotic G2-G2/M phases",0.294339428094933,0.170077450694977,0.0835195722692448,62,"ACTR1A; AJUBA; AKAP9; ALMS1; AURKA; BORA; BTRC; CCNA1; CCNA2; CCNB1; CCNB2; CCNH; CCP110; CDC25A; CDC25B; CDK1; CDK11A; CDK11B; CDK2; CDK5RAP2; CDK7; CENPF; CENPJ; CEP131; CEP135; CEP152; CEP164; CEP192; CEP250; CEP290; CEP41; CEP57; CEP63; CEP70; CEP72; CEP76; CEP78; CKAP5; CLASP1; CNTRL; CSNK1D; CSNK1E; CUL1; DCTN1; DCTN2; DYNC1H1; DYNC1I2; DYNLL1; E2F1; EP300; FBXL18; FBXL7; FBXW11; FGFR1OP; FKBPL; FOXM1; GTSE1; HAUS1; HAUS2; HAUS4; HAUS5; HAUS6"
"R-HSA-5654700","FRS-mediated FGFR2 signaling",0.506771111564938,0.293088076200518,0.0837957667613268,18,"FGF1; FGF10; FGF17; FGF18; FGF2; FGF20; FGF22; FGF5; FGF7; FGF9; FGFR2; FRS2; FRS3; GRB2; HRAS; KRAS; NRAS; SOS1"
"R-HSA-193368","Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol",-0.478017195144044,0.276834640212826,0.0842171278332697,21,"ACOT8; ACOX2; AKR1C1; AKR1C2; AKR1C3; AMACR; BAAT; CYP27A1; CYP7A1; CYP7B1; CYP8B1; HSD17B4; HSD3B7; NCOA1; NCOA2; NR1H4; PTGIS; RXRA; SCP2; SLC27A2; SLC27A5"
"R-HSA-167287","HIV elongation arrest and recovery",0.406980185392964,0.236007628297608,0.0846290602198597,30,"CCNK; CCNT1; CCNT2; CDK9; CTDP1; ELL; ELOA; ELOC; GTF2F1; GTF2F2; NELFA; NELFB; NELFCD; NELFE; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; SSRP1; SUPT16H; SUPT4H1; SUPT5H; TCEA1"
"R-HSA-167290","Pausing and recovery of HIV elongation",0.406980185392964,0.236007628297608,0.0846290602198597,30,"CCNK; CCNT1; CCNT2; CDK9; CTDP1; ELL; ELOA; ELOC; GTF2F1; GTF2F2; NELFA; NELFB; NELFCD; NELFE; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; SSRP1; SUPT16H; SUPT4H1; SUPT5H; TCEA1"
"R-HSA-169911","Regulation of Apoptosis",0.346647922725591,0.201096784607496,0.0847463923978697,43,"ARHGAP10; OMA1; OPA1; PAK2; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; SEM1; UBA52; UBC"
"R-HSA-1430728","Metabolism",0.303100106648015,0.176912505961113,0.0866616132971237,57,"AACS; AADAC; AADAT; AANAT; AASDHPPT; AASS; ABCA1; ABCB1; ABCB4; ABCC1; ABCC3; ABCC5; ABCC8; ABCD4; ABCG2; ABHD10; ABHD14B; ABHD3; ABHD4; ACAA1; ACAA2; ACACB; ACAD10; ACAD11; ACAD8; ACAD9; ACADL; ACADM; ACADS; ACADSB; ACADVL; ACAN; ACAT1; ACAT2; ACBD4; ACBD5; ACBD7; ACER2; ACER3; ACHE; ACLY; ACMSD; ACO2; ACOT1; ACOT11; ACOT12; ACOT13; ACOT2; ACOT4; ACOT6; ACOT7; ACOT8; ACOX1; ACOX2; ACOX3; ACP5; ACP6"
"R-HSA-1640170","Cell Cycle",0.294871575052632,0.172826671320979,0.0879765475432474,60,"ABL1; ACD; ACTR1A; AHCTF1; AJUBA; AKAP9; AKT1; AKT2; AKT3; ALMS1; ANAPC1; ANAPC10; ANAPC11; ANAPC15; ANAPC16; ANAPC2; ANAPC4; ANAPC5; ANAPC7; ANKLE2; ARPP19; ATM; ATR; ATRIP; AURKA; AURKB; B9D2; BABAM1; BANF1; BARD1; BIRC5; BLM; BLZF1; BORA; BRCA1; BRCA2; BRIP1; BTRC; BUB1B; BUB3; CCNA1; CCNA2; CCNB1; CCNB2; CCND1; CCND2; CCND3; CCNE1; CCNE2; CCNH; CCP110; CDC14A; CDC16; CDC25A; CDC25B; CDC26; CDC27; CDC45; CDC6; CDC7"
"R-HSA-8941858","Regulation of RUNX3 expression and activity",0.328182639969374,0.193394794737321,0.0897048008519001,47,"CBFB; CDKN2A; EP300; MDM2; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSMF1; RUNX3; SEM1; SMURF1; SMURF2; SRC; TGFB1; UBA52; UBC"
"R-HSA-5617472","Activation of anterior HOX genes in hindbrain development during early embryogenesis",0.344817378934196,0.20354989825999,0.0902616877550437,42,"AJUBA; CNOT6; CTCF; EED; EP300; EZH2; H2AFJ; H2AFV; H2AFX; H2AFZ; H2BFS; H3F3A; HDAC3; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HIST2H2AA3; HIST2H2AC; HOXA1; HOXA2; HOXA3; HOXA4; HOXB2; HOXB3; HOXB4; HOXC4; HOXD1; HOXD3; HOXD4; KMT2C; MAFB; MEIS1; NCOA3; NCOA6; NCOR1; PAX6; PAXIP1; PBX1; PIAS2; PKNOX1; POLR2A"
"R-HSA-5619507","Activation of HOX genes during differentiation",0.344817378934196,0.20354989825999,0.0902616877550437,42,"AJUBA; CNOT6; CTCF; EED; EP300; EZH2; H2AFJ; H2AFV; H2AFX; H2AFZ; H2BFS; H3F3A; HDAC3; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HIST2H2AA3; HIST2H2AC; HOXA1; HOXA2; HOXA3; HOXA4; HOXB2; HOXB3; HOXB4; HOXC4; HOXD1; HOXD3; HOXD4; KMT2C; MAFB; MEIS1; NCOA3; NCOA6; NCOR1; PAX6; PAXIP1; PBX1; PIAS2; PKNOX1; POLR2A"
"R-HSA-109688","Cleavage of Growing Transcript in the Termination Region ",0.31270955013138,0.184693463822975,0.0904312343361973,52,"ALYREF; CASC3; CDC40; CHTOP; CLP1; CPSF1; CPSF2; CPSF3; CPSF4; CPSF7; CSTF1; CSTF2T; CSTF3; DDX39A; DDX39B; DHX38; EIF4A3; FIP1L1; FYTTD1; LSM10; LSM11; MAGOH; MAGOHB; NCBP1; NCBP2; NUDT21; PAPOLA; POLDIP3; RNPS1; SARNP; SLBP; SLU7; SNRPB; SNRPD3; SNRPE; SNRPF; SRRM1; SRSF11; SRSF4; SRSF5; SRSF6; SRSF7; SRSF9; THOC1; THOC3; THOC5; THOC7; U2AF1; U2AF1L4; U2AF2; ZC3H11A; ZNF473"
"R-HSA-73856","RNA Polymerase II Transcription Termination",0.31270955013138,0.184693463822975,0.0904312343361973,52,"ALYREF; CASC3; CDC40; CHTOP; CLP1; CPSF1; CPSF2; CPSF3; CPSF4; CPSF7; CSTF1; CSTF2T; CSTF3; DDX39A; DDX39B; DHX38; EIF4A3; FIP1L1; FYTTD1; LSM10; LSM11; MAGOH; MAGOHB; NCBP1; NCBP2; NUDT21; PAPOLA; POLDIP3; RNPS1; SARNP; SLBP; SLU7; SNRPB; SNRPD3; SNRPE; SNRPF; SRRM1; SRSF11; SRSF4; SRSF5; SRSF6; SRSF7; SRSF9; THOC1; THOC3; THOC5; THOC7; U2AF1; U2AF1L4; U2AF2; ZC3H11A; ZNF473"
"R-HSA-73780","RNA Polymerase III Chain Elongation",0.509178658634738,0.301209336530711,0.0909423178707882,17,"CRCP; POLR1C; POLR1D; POLR2E; POLR2F; POLR2H; POLR2K; POLR2L; POLR3A; POLR3B; POLR3C; POLR3D; POLR3F; POLR3G; POLR3GL; POLR3H; POLR3K"
"R-HSA-211859","Biological oxidations",-0.292537812084329,0.173283912900947,0.091372942539766,61,"AADAC; ABHD10; ABHD14B; ACSM1; ACSM4; ACSM5; ACSS1; ACSS2; ACY1; ACY3; ADH1A; ADH1B; ADH4; ADH5; ADH6; AHCY; AHR; AHRR; AIP; AKR1A1; AKR7A2; AKR7A3; ALDH1A1; ALDH1B1; ALDH2; ALDH3A1; AOC1; AOC2; AOC3; ARNT; ARNT2; AS3MT; BPHL; BPNT1; CBR3; CES1; CES2; CES3; CHAC1; CHAC2; CMBL; CNDP2; COMT; CYB5B; CYB5R3; CYP11A1; CYP11B1; CYP17A1; CYP19A1; CYP1A1; CYP1A2; CYP1B1; CYP21A2; CYP24A1; CYP26B1; CYP26C1; CYP27A1; CYP27B1; CYP2A13; CYP2A6; CYP2A7"
"R-HSA-174113","SCF-beta-TrCP mediated degradation of Emi1",0.336375020818652,0.199373956757204,0.091573307902596,44,"BTRC; CUL1; FBXO5; FZR1; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; SEM1; SKP1; UBA52; UBC"
"R-HSA-195721","Signaling by WNT",0.287313490392141,0.170347703319,0.0916745834374842,62,"AES; AGO1; AGO2; AGO3; AGO4; AKT1; AKT2; AP2A1; AP2A2; AP2B1; AP2M1; AP2S1; APC; ARRB2; AXIN1; AXIN2; BCL9; BTRC; CALM1; CAMK2A; CAV1; CBY1; CCDC88C; CDC73; CHD8; CLTA; CLTB; CLTC; CSNK1A1; CSNK1E; CSNK1G2; CSNK2A2; CSNK2B; CTBP1; CTBP2; CTNNB1; CTNNBIP1; CUL1; CUL3; CXXC4; DAAM1; DACT1; DKK1; DKK4; DVL1; DVL2; DVL3; EP300; FRAT1; FRAT2; FZD1; FZD2; FZD3; FZD4; FZD5; FZD6; FZD7; FZD8; GNAO1; GNAT2; GNB1; GNB2"
"R-HSA-8876198","RAB GEFs exchange GTP for GDP on RABs",0.294686941889097,0.175746484186648,0.0935868990410946,58,"AKT1; AKT2; AKT3; ALS2; ALS2CL; ANKRD27; CCZ1; CCZ1B; CHML; DENND1A; DENND1B; DENND1C; DENND2A; DENND2C; DENND2D; DENND3; DENND4A; DENND4B; DENND4C; DENND5A; DENND5B; DENND6A; DENND6B; GAPVD1; GDI2; HPS1; HPS4; MADD; MON1A; MON1B; RAB10; RAB12; RAB13; RAB14; RAB18; RAB1A; RAB27A; RAB27B; RAB31; RAB32; RAB35; RAB38; RAB3A; RAB3GAP2; RAB3IL1; RAB3IP; RAB5A; RAB5B; RAB5C; RAB6A; RAB6B; RAB7A; RAB8A; RAB8B; RABGEF1; RGP1; RIC1; RIN1"
"R-HSA-159854","Gamma-carboxylation, transport, and amino-terminal cleavage of proteins",0.623599931104563,0.371919068991646,0.0935994625086635,10,"BGLAP; F10; F2; F7; FURIN; GAS6; GGCX; PROC; PROS1; PROZ"
"R-HSA-199977","ER to Golgi Anterograde Transport",-0.283779136820637,0.169538714268953,0.0941638398068725,64,"ACTR10; ACTR1A; ANK1; ANK2; ANK3; ANKRD28; ARCN1; AREG; ARF3; ARF4; ARF5; ARFGAP1; ARFGAP2; ARFGAP3; BET1; BET1L; CAPZA1; CAPZA2; CAPZA3; CAPZB; CD55; CD59; CNIH1; CNIH2; CNIH3; COG1; COG2; COG3; COG4; COG5; COG6; COG7; COG8; COPA; COPB1; COPB2; COPE; COPG1; COPG2; COPZ1; COPZ2; CSNK1D; CTAGE5; CTSC; CTSZ; DCTN1; DCTN2; DCTN4; DCTN5; DCTN6; DYNC1H1; DYNC1I1; DYNC1I2; DYNC1LI1; DYNC1LI2; DYNLL1; DYNLL2; F5; FOLR1; GBF1; GOLGA2; GOLGB1; GORASP1; GOSR1"
"R-HSA-5654221","Phospholipase C-mediated cascade; FGFR2",0.580344233651292,0.346980903283631,0.0944151653118721,12,"FGF1; FGF10; FGF17; FGF18; FGF2; FGF20; FGF22; FGF5; FGF7; FGF9; FGFR2; PLCG1"
"R-HSA-163200","Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.",-0.311901596447799,0.186684018317183,0.0947718379927464,52,"ACAD9; ATP5A1; ATP5B; ATP5C1; ATP5D; ATP5E; ATP5F1; ATP5G1; ATP5G2; ATP5G3; ATP5H; ATP5I; ATP5J2; ATP5L; ATP5O; ATP5S; COQ10A; COQ10B; COX11; COX14; COX16; COX18; COX19; COX20; COX4I1; COX5A; COX5B; COX6A1; COX6B1; COX6C; COX7A2L; COX8A; CYC1; CYCS; ECSIT; ETFA; ETFB; ETFDH; LRPPRC; NDUFA10; NDUFA11; NDUFA12; NDUFA13; NDUFA2; NDUFA3; NDUFA4; NDUFA5; NDUFA6; NDUFA7; NDUFA8; NDUFA9; NDUFAB1"
"R-HSA-8854518","AURKA Activation by TPX2",0.286398678144433,0.171753518154639,0.0954153869208191,61,"ACTR1A; AKAP9; ALMS1; AURKA; CCP110; CDK1; CDK5RAP2; CENPJ; CEP131; CEP135; CEP152; CEP164; CEP192; CEP250; CEP290; CEP41; CEP57; CEP63; CEP70; CEP72; CEP76; CEP78; CKAP5; CLASP1; CNTRL; CSNK1D; CSNK1E; DCTN1; DCTN2; DYNC1H1; DYNC1I2; DYNLL1; FGFR1OP; HAUS1; HAUS2; HAUS4; HAUS5; HAUS6; HAUS8; HMMR; HSP90AA1; MAPRE1; NDE1; NEDD1; NEK2; NINL; ODF2; PAFAH1B1; PCM1; PCNT; PLK1; PLK4; PPP2R1A; PRKAR2B; SDCCAG8; SFI1; SSNA1; TPX2; TUBA1A; TUBA4A; TUBB4A"
"R-HSA-8876725","Protein methylation",0.560706978556919,0.336504098958317,0.0956594754725011,13,"CALM1; CAMKMT; EEF2; EEF2KMT; ETFB; ETFBKMT; HSPA8; KIN; METTL21A; METTL22; RPS2; VCP; VCPKMT"
"R-HSA-264642","Acetylcholine Neurotransmitter Release Cycle",-0.517957543436274,0.310969940668479,0.095789259092757,16,"CPLX1; PPFIA1; PPFIA2; PPFIA3; PPFIA4; RAB3A; RIMS1; SLC18A3; SLC5A7; SNAP25; STX1A; STXBP1; SYT1; TSPOAP1; UNC13B; VAMP2"
"R-HSA-1296071","Potassium Channels",0.295202829461428,0.177238928165373,0.0958002287577365,57,"ABCC8; ABCC9; GABBR1; GABBR2; GNB1; GNB2; GNB3; GNG10; GNG12; GNG2; GNG3; GNG4; GNG5; GNG7; GNGT2; HCN1; HCN2; HCN3; KCNA1; KCNA2; KCNA3; KCNA4; KCNA7; KCNAB1; KCNAB2; KCNAB3; KCNB1; KCNB2; KCNC1; KCNC2; KCNC3; KCNC4; KCND3; KCNF1; KCNG1; KCNG2; KCNG4; KCNH1; KCNH2; KCNH3; KCNH4; KCNH5; KCNH6; KCNH7; KCNJ1; KCNJ10; KCNJ11; KCNJ12; KCNJ14; KCNJ15; KCNJ16; KCNJ2; KCNJ3; KCNJ4; KCNJ5; KCNJ6; KCNJ8"
"R-HSA-210745","Regulation of gene expression in beta cells",0.560494357820126,0.336536328376958,0.0958171290694731,13,"AKT1; AKT2; AKT3; FOXO1; GCK; HNF1A; HNF4G; MAFA; NEUROD1; NKX6-1; PAX6; PDX1; PKLR"
"R-HSA-6796648","TP53 Regulates Transcription of DNA Repair Genes",0.300032982823319,0.180185658365472,0.0958863383471132,55,"ATF2; ATM; ATR; BRCA1; CCNH; CCNK; CCNT1; CCNT2; CDK13; CDK7; CDK9; CHEK1; CTDP1; DDB2; ELL; ELOA; ELOC; ERCC3; FANCC; FANCD2; FANCI; FOS; GTF2F1; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; GTF2H5; MDC1; MLH1; MNAT1; MSH2; NELFA; NELFB; NELFCD; NELFE; PMS2; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; RAD51D; SSRP1; SUPT16H; SUPT4H1; SUPT5H; TCEA1"
"R-HSA-392518","Signal amplification",0.400388837376871,0.240507524071135,0.095959376164107,29,"GNA11; GNA13; GNA14; GNA15; GNAI1; GNAI2; GNAI3; GNAQ; GNAT3; GNB1; GNB2; GNB3; GNB4; GNB5; GNG10; GNG11; GNG12; GNG2; GNG3; GNG4; GNG5; GNG7; GNGT2; MAPK14; P2RY1; P2RY12; PLA2G4A; SRC; TBXA2R"
"R-HSA-2219528","PI3K/AKT Signaling in Cancer",0.305037351989341,0.183304585536655,0.0960922386667245,53,"AKT1; AKT1S1; AKT2; AKT3; BAD; BTC; CASP9; CD19; CD28; CD80; CD86; CDKN1B; CHUK; EGF; EGFR; ERBB2; ERBB3; ERBB4; EREG; ESR1; ESR2; FGF1; FGF10; FGF17; FGF18; FGF2; FGF20; FGF22; FGF5; FGF7; FGF9; FGFR1; FGFR2; FGFR3; FGFR4; FOXO1; FOXO3; FRS2; FYN; GAB1; GRB2; GSK3B; HGF; IRS1; IRS2; KIT; KL; KLB; MAPKAP1; MDM2; MET; MLST8; MTOR"
"R-HSA-1369062","ABC transporters in lipid homeostasis",0.528812270335191,0.317873012042556,0.0961931924360628,15,"ABCA10; ABCA2; ABCA3; ABCA5; ABCA6; ABCA7; ABCA9; ABCD2; ABCD3; ABCG1; ABCG4; ABCG5; ABCG8; APOA1; PEX3"
"R-HSA-198323","AKT phosphorylates targets in the cytosol",0.577186043303387,0.347490980389022,0.0967114094589796,12,"AKT1; AKT1S1; AKT2; AKT3; BAD; CASP9; CDKN1B; CHUK; GSK3B; MDM2; MKRN1; TSC2"
"R-HSA-72695","Formation of the ternary complex, and subsequently, the 43S complex",-0.331258797408114,0.19955929624368,0.0969241651729758,45,"EIF2S1; EIF2S2; EIF3A; EIF3B; EIF3C; EIF3D; EIF3E; EIF3F; EIF3G; EIF3H; EIF3I; EIF3J; EIF3K; EIF3L; EIF3M; FAU; RPS10; RPS11; RPS12; RPS13; RPS14; RPS15; RPS15A; RPS16; RPS18; RPS19; RPS2; RPS20; RPS21; RPS23; RPS24; RPS25; RPS26; RPS27; RPS27L; RPS28; RPS29; RPS3; RPS3A; RPS5; RPS6; RPS7; RPS8; RPS9; RPSA"
"R-HSA-5358346","Hedgehog ligand biogenesis",0.298730840716833,0.180240646294186,0.0974386386551523,55,"ADAM17; DERL2; DHH; DISP2; ERLEC1; GPC5; HHAT; IHH; NOTUM; OS9; P4HB; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; SCUBE2; SEL1L; SEM1; SHH; SYVN1; UBA52; UBC; VCP"
"R-HSA-5637810","Constitutive Signaling by EGFRvIII",0.52615796489463,0.318230562973184,0.0982523256213758,15,"CBL; CDC37; EGF; EGFR; GAB1; GRB2; HRAS; HSP90AA1; KRAS; NRAS; PIK3CA; PIK3R1; PLCG1; SHC1; SOS1"
"R-HSA-5637812","Signaling by EGFRvIII in Cancer",0.52615796489463,0.318230562973184,0.0982523256213758,15,"CBL; CDC37; EGF; EGFR; GAB1; GRB2; HRAS; HSP90AA1; KRAS; NRAS; PIK3CA; PIK3R1; PLCG1; SHC1; SOS1"
"R-HSA-1989781","PPARA activates gene expression",-0.28592703508857,0.173520761918201,0.0993942826256932,61,"ABCA1; ABCB4; ACADM; ACOX1; ACSL1; AGT; AHR; AHRR; ALAS1; ANGPTL4; ANKRD1; APOA1; APOA2; ARNT; ARNT2; ARNTL; CARM1; CCNC; CD36; CDK19; CDK8; CHD9; CLOCK; CPT1A; CPT2; CTGF; CYP1A1; CYP4A11; CYP7A1; EP300; ESRRA; FABP1; FADS1; FAM120B; FDFT1; FHL2; G0S2; GLIPR1; GRHL1; HDAC3; HMGCR; HMGCS1; HMGCS2; ME1; MED10; MED11; MED13; MED13L; MED15; MED16; MED17; MED19; MED20; MED21; MED22; MED23; MED24; MED25; MED26; MED27; MED28"
"R-HSA-400206","Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)",-0.28592703508857,0.173520761918201,0.0993942826256932,61,"ABCA1; ABCB4; ACADM; ACOX1; ACSL1; AGT; AHR; AHRR; ALAS1; ANGPTL4; ANKRD1; APOA1; APOA2; ARNT; ARNT2; ARNTL; CARM1; CCNC; CD36; CDK19; CDK8; CHD9; CLOCK; CPT1A; CPT2; CTGF; CYP1A1; CYP4A11; CYP7A1; EP300; ESRRA; FABP1; FADS1; FAM120B; FDFT1; FHL2; G0S2; GLIPR1; GRHL1; HDAC3; HMGCR; HMGCS1; HMGCS2; ME1; MED10; MED11; MED13; MED13L; MED15; MED16; MED17; MED19; MED20; MED21; MED22; MED23; MED24; MED25; MED26; MED27; MED28"
"R-HSA-69229","Ubiquitin-dependent degradation of Cyclin D1",0.338864200642321,0.206319899337386,0.100502720314248,41,"CCND1; CDK4; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; SEM1; UBA52; UBC"
"R-HSA-75815","Ubiquitin-dependent degradation of Cyclin D",0.338864200642321,0.206319899337386,0.100502720314248,41,"CCND1; CDK4; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; SEM1; UBA52; UBC"
"R-HSA-162588","Budding and maturation of HIV virion",-0.41807093696828,0.254950740025395,0.101044544556521,26,"CHMP2A; CHMP2B; CHMP3; CHMP4A; CHMP4B; CHMP4C; CHMP5; CHMP6; CHMP7; MVB12A; MVB12B; NEDD4L; PDCD6IP; PPIA; TSG101; UBA52; UBAP1; UBC; VPS28; VPS37A; VPS37B; VPS37C; VPS37D; VPS4A; VPS4B; VTA1"
"R-HSA-76071","RNA Polymerase III Transcription Initiation From Type 3 Promoter",0.40745779384618,0.248603853247164,0.101216545006902,27,"BDP1; BRF2; CRCP; POLR1C; POLR1D; POLR2E; POLR2F; POLR2H; POLR2K; POLR2L; POLR3A; POLR3B; POLR3C; POLR3D; POLR3F; POLR3G; POLR3GL; POLR3H; POLR3K; POU2F1; SNAPC1; SNAPC2; SNAPC3; SNAPC4; SNAPC5; TBP; ZNF143"
"R-HSA-190828","Gap junction trafficking",0.472680894246842,0.289178514137711,0.102140403049539,19,"AP2M1; CLTA; CLTB; CLTC; CLTCL1; DAB2; DNM1; DNM2; GJA1; GJA3; GJA4; GJB2; GJB3; GJB4; GJB5; GJB6; GJC1; GJD2; MYO6"
"R-HSA-174154","APC/C:Cdc20 mediated degradation of Securin",0.296745094562979,0.181963616286517,0.10293388566215,54,"ANAPC1; ANAPC10; ANAPC11; ANAPC15; ANAPC16; ANAPC2; ANAPC4; ANAPC5; ANAPC7; CDC16; CDC26; CDC27; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; PTTG1; SEM1; UBA52; UBC; UBE2D1; UBE2E1"
"R-HSA-69278","Cell Cycle, Mitotic",0.282441472961064,0.17331119319919,0.103169527642901,60,"ABL1; ACTR1A; AHCTF1; AJUBA; AKAP9; AKT1; AKT2; AKT3; ALMS1; ANAPC1; ANAPC10; ANAPC11; ANAPC15; ANAPC16; ANAPC2; ANAPC4; ANAPC5; ANAPC7; ANKLE2; ARPP19; AURKA; AURKB; B9D2; BANF1; BIRC5; BLZF1; BORA; BTRC; BUB1B; BUB3; CCNA1; CCNA2; CCNB1; CCNB2; CCND1; CCND2; CCND3; CCNE1; CCNE2; CCNH; CCP110; CDC14A; CDC16; CDC25A; CDC25B; CDC26; CDC27; CDC45; CDC6; CDC7; CDCA5; CDK1; CDK11A; CDK11B; CDK2; CDK4; CDK5RAP2; CDK6; CDK7; CDKN1B"
"R-HSA-450408","AUF1 (hnRNP D0) binds and destabilizes mRNA",0.328591522958678,0.202063943387911,0.103912233043067,43,"EIF4G1; HSPA8; HSPB1; PABPC1; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; SEM1; UBA52; UBC"
"R-HSA-418592","ADP signalling through P2Y purinoceptor 1",0.442091679707413,0.2719300970444,0.104001812263938,22,"GNA11; GNA14; GNA15; GNAQ; GNB1; GNB2; GNB3; GNB4; GNB5; GNG10; GNG11; GNG12; GNG2; GNG3; GNG4; GNG5; GNG7; GNGT2; MAPK14; P2RY1; PLA2G4A; SRC"
"R-HSA-622312","Inflammasomes",-0.507058750983,0.312571018444032,0.104756392274634,16,"AIM2; APP; BCL2; BCL2L1; CASP1; HSP90AB1; MEFV; NLRC4; NLRP1; NLRP3; P2RX7; PANX1; PSTPIP1; PYCARD; SUGT1; TXN"
"R-HSA-877300","Interferon gamma signaling",0.283382744080421,0.174717145380515,0.104813723338157,59,"B2M; CAMK2A; CAMK2B; CAMK2D; CAMK2G; CD44; CIITA; FCGR1A; FCGR1B; GBP1; GBP3; GBP4; GBP5; GBP7; HLA-A; HLA-B; HLA-C; HLA-DPA1; HLA-DPB1; HLA-DQA1; HLA-DQA2; HLA-DQB1; HLA-DQB2; HLA-DRA; HLA-DRB1; HLA-DRB5; HLA-E; HLA-F; HLA-G; ICAM1; IFI30; IFNGR1; IFNGR2; IRF1; IRF3; IRF4; IRF5; IRF6; IRF7; IRF8; IRF9; JAK1; JAK2; MT2A; NCAM1; OAS1; OAS2; OAS3; OASL; PIAS1; PML; PRKCD; PTAFR; PTPN1; PTPN2; PTPN6; SOCS1; SOCS3; SP100"
"R-HSA-5660526","Response to metal ions",-0.549775141813479,0.339098993877394,0.104957143979826,13,"CSRP1; MT1A; MT1B; MT1E; MT1F; MT1G; MT1M; MT1X; MT2A; MT3; MT4; MTF1; SNCB"
"R-HSA-8862803","Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models",-0.462688068914399,0.285397274393671,0.104973244602712,20,"APP; BCL2L11; CAPN1; CAPN2; CAPNS1; CAPNS2; CAST; CDC25A; CDC25B; CDK5R1; FASLG; FOXO3; GOLGA2; LMNA; LMNB1; PRDX1; PRDX2; SOD2; STAT4; YWHAE"
"R-HSA-8863678","Neurodegenerative Diseases",-0.462688068914399,0.285397274393671,0.104973244602712,20,"APP; BCL2L11; CAPN1; CAPN2; CAPNS1; CAPNS2; CAST; CDC25A; CDC25B; CDK5R1; FASLG; FOXO3; GOLGA2; LMNA; LMNB1; PRDX1; PRDX2; SOD2; STAT4; YWHAE"
"R-HSA-5693606","DNA Double Strand Break Response",0.330948406072128,0.204303263412147,0.105256336674457,42,"ABL1; APBB1; ATM; BABAM1; BAP1; BARD1; BAZ1B; BRCA1; CHEK2; EYA1; EYA2; EYA3; EYA4; FAM175A; H2AFX; H2BFS; HERC2; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; KAT5; KDM4A; KDM4B; KPNA2; MAPK8; MDC1; MRE11; NBN; PIAS4; PPP5C; RAD50; RNF168; RNF8; SMARCA5; SUMO1; TP53BP1; UBA52; UBC; UBE2I; UBE2N; UIMC1"
"R-HSA-1236382","Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants",0.49089975070298,0.303425291125042,0.105692694740701,17,"CBL; CDC37; EGF; EGFR; GAB1; GRB2; HRAS; HSP90AA1; KRAS; NRAS; PIK3CA; PIK3R1; PLCG1; SHC1; SOS1; UBA52; UBC"
"R-HSA-1643713","Signaling by EGFR in Cancer",0.49089975070298,0.303425291125042,0.105692694740701,17,"CBL; CDC37; EGF; EGFR; GAB1; GRB2; HRAS; HSP90AA1; KRAS; NRAS; PIK3CA; PIK3R1; PLCG1; SHC1; SOS1; UBA52; UBC"
"R-HSA-5637815","Signaling by Ligand-Responsive EGFR Variants in Cancer",0.49089975070298,0.303425291125042,0.105692694740701,17,"CBL; CDC37; EGF; EGFR; GAB1; GRB2; HRAS; HSP90AA1; KRAS; NRAS; PIK3CA; PIK3R1; PLCG1; SHC1; SOS1; UBA52; UBC"
"R-HSA-73857","RNA Polymerase II Transcription",0.291585014235885,0.1805389796421,0.106293228755369,55,"ABL1; ACTL6A; AFF4; AGO1; AGO2; AGO3; AGO4; AIFM2; AKT1; AKT2; AKT3; ALYREF; APAF1; ARID1B; ARID2; ARID3A; ATAD2; ATF2; ATM; ATR; ATRIP; AURKA; AURKB; AUTS2; AXIN1; BANP; BARD1; BAX; BBC3; BCL2L11; BCL2L14; BGLAP; BID; BIRC5; BLK; BLM; BMI1; BNIP3L; BRCA1; BRD2; BRD7; BRIP1; BRPF3; CARM1; CASC3; CASP1; CASP10; CASP6; CBFB; CBX2; CBX3; CBX4; CBX5; CBX6; CBX8"
"R-HSA-2022854","Keratan sulfate biosynthesis",-0.40475629164129,0.25138675946666,0.107377355382554,27,"ACAN; B3GNT2; B3GNT3; B3GNT4; B3GNT7; B4GALT1; B4GALT2; B4GALT3; B4GALT4; B4GALT5; B4GALT6; B4GAT1; CHST1; CHST2; CHST5; CHST6; FMOD; KERA; LUM; OGN; OMD; PRELP; SLC35D2; ST3GAL1; ST3GAL3; ST3GAL4; ST3GAL6"
"R-HSA-5676590","NIK-->noncanonical NF-kB signaling",0.311689824720346,0.194199058969083,0.108493424956954,47,"BTRC; CHUK; CUL1; FBXW11; NFKB2; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; SEM1; SKP1; UBA3; UBA52; UBC; UBE2M"
"R-HSA-3295583","TRP channels",0.445803100853134,0.277901926877226,0.108675660287871,21,"MCOLN2; MCOLN3; TRPC1; TRPC3; TRPC4; TRPC4AP; TRPC6; TRPM1; TRPM2; TRPM3; TRPM4; TRPM5; TRPM6; TRPM7; TRPM8; TRPV1; TRPV2; TRPV3; TRPV4; TRPV5; TRPV6"
"R-HSA-174417","Telomere C-strand (Lagging Strand) Synthesis",-0.44885003723353,0.280121297143977,0.109080067816714,21,"DNA2; LIG1; PCNA; POLA2; POLD1; POLD2; POLD3; POLE; POLE2; POLE3; POLE4; PRIM1; PRIM2; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3"
"R-HSA-913531","Interferon Signaling",0.291626945736747,0.182179005238899,0.109427554879517,54,"ABCE1; ADAR; ARIH1; B2M; BST2; CAMK2A; CAMK2B; CAMK2D; CAMK2G; CD44; CIITA; DDX58; EGR1; EIF2AK2; EIF4A1; EIF4A2; EIF4A3; EIF4E; EIF4E2; EIF4E3; EIF4G1; EIF4G2; EIF4G3; FCGR1A; FCGR1B; FLNB; GBP1; GBP3; GBP4; GBP5; GBP7; HLA-A; HLA-B; HLA-C; HLA-DPA1; HLA-DPB1; HLA-DQA1; HLA-DQA2; HLA-DQB1; HLA-DQB2; HLA-DRA; HLA-DRB1; HLA-DRB5; HLA-E; HLA-F; HLA-G; ICAM1; IFI30; IFI35; IFIT1; IFIT3; IFITM1; IFITM2; IFITM3"
"R-HSA-203615","eNOS activation",0.579943471155126,0.362340260790501,0.109476766839964,11,"AKT1; CALM1; CAV1; CYGB; DDAH1; DDAH2; HSP90AA1; LYPLA1; NOS3; SPR; ZDHHC21"
"R-HSA-2559582","Senescence-Associated Secretory Phenotype (SASP)",0.316814363277566,0.198166632660058,0.109881256331601,45,"ANAPC1; ANAPC10; ANAPC11; ANAPC15; ANAPC16; ANAPC2; ANAPC4; ANAPC5; ANAPC7; CCNA1; CCNA2; CDC16; CDC26; CDC27; CDK2; CDK4; CDK6; CDKN1B; CDKN2A; CDKN2B; CDKN2C; CDKN2D; CEBPB; CXCL8; EHMT1; EHMT2; FOS; FZR1; H2AFJ; H2AFV; H2AFX; H2AFZ; H2BFS; H3F3A; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HIST2H2AA3; HIST2H2AC; IGFBP7; IL1A; MAPK1; MAPK3; NFKB1"
"R-HSA-71384","Ethanol oxidation",-0.599905288413457,0.375305023760754,0.109943473037151,10,"ACSS1; ACSS2; ADH1A; ADH1B; ADH4; ADH5; ADH6; ALDH1A1; ALDH1B1; ALDH2"
"R-HSA-6804759","Regulation of TP53 Activity through Association with Co-factors",0.578596001664066,0.362568446725027,0.110527740580234,11,"AKT1; AKT2; AKT3; BANP; PHF20; POU4F1; PPP1R13B; TP53BP2; TP63; TP73; ZNF385A"
"R-HSA-674695","RNA Polymerase II Pre-transcription Events",0.281165444662019,0.176283010988976,0.110719793734535,58,"AFF4; CCNH; CCNK; CCNT1; CCNT2; CDC73; CDK7; CDK9; CTDP1; CTR9; EAF1; EAF2; ELL; ELOA; ELOC; ERCC3; GTF2A1; GTF2A2; GTF2B; GTF2E1; GTF2E2; GTF2F1; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; GTF2H5; IWS1; LEO1; MLLT3; MNAT1; NCBP1; NCBP2; NELFA; NELFB; NELFCD; NELFE; PAF1; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; RTF1; SSRP1; SUPT16H; SUPT4H1; SUPT5H; SUPT6H; TAF10; TAF11"
"R-HSA-181429","Serotonin Neurotransmitter Release Cycle",-0.500016805794153,0.313587120306222,0.11082256172453,16,"CPLX1; PPFIA1; PPFIA2; PPFIA3; PPFIA4; RAB3A; RIMS1; SLC18A2; SNAP25; STX1A; STXBP1; SYN3; SYT1; TSPOAP1; UNC13B; VAMP2"
"R-HSA-446203","Asparagine N-linked glycosylation",-0.272963838774861,0.171222743119621,0.110890538165629,63,"ACTR10; ACTR1A; ALG1; ALG10; ALG11; ALG12; ALG14; ALG3; ALG5; ALG6; ALG8; ALG9; AMDHD2; AMFR; ANK1; ANK2; ANK3; ANKRD28; ARCN1; AREG; ARF3; ARF4; ARF5; ARFGAP1; ARFGAP2; ARFGAP3; ASGR1; ASGR2; B4GALNT2; B4GALT1; B4GALT2; B4GALT3; B4GALT4; B4GALT5; B4GALT6; BET1; BET1L; CALR; CANX; CAPZA1; CAPZA2; CAPZA3; CAPZB; CD55; CD59; CGA; CHST10; CHST8; CMAS; CNIH1; CNIH2; CNIH3; COG1; COG2; COG3; COG4; COG5; COG6; COG7; COG8; COPA; COPB1; COPB2"
"R-HSA-5607761","Dectin-1 mediated noncanonical NF-kB signaling",0.300277625441879,0.188870213670901,0.11186585537202,50,"BTRC; CCL17; CCL22; CHUK; CUL1; FBXW11; NFKB2; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; RELA; SEM1; SKP1; UBA3; UBA52; UBC; UBE2M"
"R-HSA-2408517","SeMet incorporation into proteins",0.57650264196305,0.362922283287404,0.112172950644216,11,"AIMP1; AIMP2; DARS; EEF1E1; EPRS; IARS; KARS; LARS; MARS; QARS; RARS"
"R-HSA-432047","Passive transport by Aquaporins",0.576216886719775,0.362970521259837,0.112398708629106,11,"AQP1; AQP10; AQP11; AQP12A; AQP3; AQP4; AQP5; AQP6; AQP7; AQP8; AQP9"
"R-HSA-1793185","Chondroitin sulfate/dermatan sulfate metabolism",-0.324258083949183,0.204447403058744,0.112734313674245,43,"AGRN; ARSB; B3GALT6; B3GAT1; B3GAT2; B3GAT3; B4GALT7; BCAN; CHPF; CHPF2; CHST11; CHST12; CHST13; CHST15; CHST3; CHST9; CHSY1; CHSY3; CSGALNACT1; CSGALNACT2; CSPG4; CSPG5; DCN; DSE; DSEL; GPC1; GPC2; GPC5; GPC6; HEXA; HEXB; HSPG2; HYAL1; HYAL3; IDUA; SDC1; SDC2; SDC3; SDC4; UST; VCAN; XYLT1; XYLT2"
"R-HSA-390918","Peroxisomal lipid metabolism",0.402346465147076,0.253713476389115,0.112777857900947,26,"ACAA1; ACBD4; ACBD5; ACOT4; ACOT6; ACOT8; ACOX1; ACOX2; ACOX3; ALDH3A2; AMACR; CRAT; CROT; DECR2; ECI2; EHHADH; HACL1; HAO2; HSD17B4; NUDT19; NUDT7; PECR; PHYH; SCP2; SLC25A17; SLC27A2"
"R-HSA-4086400","PCP/CE pathway",0.277200573201584,0.174954826330903,0.113099931935514,59,"AP2A1; AP2A2; AP2B1; AP2M1; AP2S1; ARRB2; CLTA; CLTB; CLTC; DAAM1; DVL1; DVL2; DVL3; FZD1; FZD2; FZD3; FZD4; FZD5; FZD6; FZD7; FZD8; PARD6A; PFN1; PRICKLE1; PRKCA; PRKCB; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2"
"R-HSA-70895","Branched-chain amino acid catabolism",0.44063152652489,0.278413083271923,0.113500391973714,21,"ACAD8; ACADSB; ACAT1; ALDH6A1; ALDH9A1; AUH; BBOX1; BCAT1; BCAT2; BCKDHA; BCKDHB; BCKDK; DBT; DLD; HIBADH; HIBCH; IVD; MCCC1; MCCC2; PPM1K; SHMT1"
"R-HSA-2565942","Regulation of PLK1 Activity at G2/M Transition",0.267590837496745,0.169733571853683,0.114902666706126,63,"ACTR1A; AJUBA; AKAP9; ALMS1; AURKA; BORA; BTRC; CCNB1; CCNB2; CCP110; CDK1; CDK5RAP2; CENPJ; CEP131; CEP135; CEP152; CEP164; CEP192; CEP250; CEP290; CEP41; CEP57; CEP63; CEP70; CEP72; CEP76; CEP78; CKAP5; CLASP1; CNTRL; CSNK1D; CSNK1E; CUL1; DCTN1; DCTN2; DYNC1H1; DYNC1I2; DYNLL1; FBXW11; FGFR1OP; HAUS1; HAUS2; HAUS4; HAUS5; HAUS6; HAUS8; HSP90AA1; MAPRE1; NDE1; NEDD1; NEK2; NINL; ODF2; OPTN; PAFAH1B1; PCM1; PCNT; PLK1; PLK4; PPP1CB; PPP1R12A; PPP1R12B; PPP2R1A"
"R-HSA-202424","Downstream TCR signaling",0.281647003254764,0.179342418095638,0.116312139598859,56,"BCL10; BTRC; CARD11; CD247; CD3D; CD3E; CD4; CDC34; CHUK; CUL1; FBXW11; HLA-DPA1; HLA-DPB1; HLA-DQA1; HLA-DQA2; HLA-DQB1; HLA-DQB2; HLA-DRA; HLA-DRB1; HLA-DRB5; IKBKB; INPP5D; MALT1; MAP3K7; NFKB1; NFKBIA; PDPK1; PIK3CA; PIK3CB; PIK3R1; PIK3R2; PRKCQ; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13"
"R-HSA-113418","Formation of the Early Elongation Complex",0.368424817812858,0.234981154744093,0.11690659228038,31,"CCNH; CDK7; CTDP1; ERCC3; GTF2F1; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; GTF2H5; MNAT1; NCBP1; NCBP2; NELFA; NELFB; NELFCD; NELFE; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; SUPT4H1; SUPT5H"
"R-HSA-167158","Formation of the HIV-1 Early Elongation Complex",0.368424817812858,0.234981154744093,0.11690659228038,31,"CCNH; CDK7; CTDP1; ERCC3; GTF2F1; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; GTF2H5; MNAT1; NCBP1; NCBP2; NELFA; NELFB; NELFCD; NELFE; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; SUPT4H1; SUPT5H"
"R-HSA-180534","Vpu mediated degradation of CD4",0.321052553385949,0.204825594203848,0.117011054783989,42,"BTRC; CD4; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; SEM1; SKP1; UBA52; UBC"
"R-HSA-196807","Nicotinate metabolism",-0.376654907627317,0.24078316139603,0.117749268819564,30,"BST1; CD38; CYP8B1; NADK; NADK2; NADSYN1; NAMPT; NAPRT; NAXD; NAXE; NMNAT1; NMNAT2; NMNAT3; NMRK1; NMRK2; NNMT; NT5E; NUDT12; PARP10; PARP14; PARP16; PARP4; PARP6; PARP8; PARP9; PTGIS; PTGS2; QPRT; RNLS; SLC5A8"
"R-HSA-156584","Cytosolic sulfonation of small molecules",-0.421407532908835,0.270565566993454,0.11935036303516,23,"ABHD14B; BPNT1; IMPAD1; PAPSS1; PAPSS2; PODXL2; SLC26A1; SLC26A2; SLC35B2; SLC35B3; SULT1A1; SULT1A2; SULT1A3; SULT1A4; SULT1B1; SULT1C2; SULT1C4; SULT1E1; SULT2A1; SULT2B1; SULT4A1; TPST1; TPST2"
"R-HSA-1250347","SHC1 events in ERBB4 signaling",0.567286422306157,0.36447037882819,0.119596884925011,11,"BTC; ERBB4; EREG; GRB2; HRAS; KRAS; NRAS; NRG1; NRG4; SHC1; SOS1"
"R-HSA-453279","Mitotic G1-G1/S phases",0.262016492571089,0.168615847246009,0.120202148958741,64,"ABL1; AKT1; AKT2; AKT3; CCNA1; CCNA2; CCNB1; CCND1; CCND2; CCND3; CCNE1; CCNE2; CCNH; CDC25A; CDC45; CDC6; CDC7; CDK1; CDK2; CDK4; CDK6; CDK7; CDKN1B; CDKN1C; CDKN2A; CDKN2B; CDKN2C; CDKN2D; CDT1; CUL1; DBF4; DHFR; DYRK1A; E2F1; E2F2; E2F4; E2F5; E2F6; FBXO5; HDAC1; JAK2; LIN37; LIN52; LIN54; LIN9; LYN; MAX; MCM10; MCM2; MCM3; MCM4; MCM5; MCM6; MCM7; MCM8; MNAT1; MYBL2; MYC; ORC1; ORC3; ORC4; ORC5; ORC6; PCNA"
"R-HSA-69186","Lagging Strand Synthesis",-0.476996076674944,0.307441149542207,0.120781024748595,17,"DNA2; LIG1; PCNA; POLA2; POLD1; POLD2; POLD3; PRIM1; PRIM2; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3"
"R-HSA-70263","Gluconeogenesis",0.381205858836714,0.246190606124805,0.121521794934411,28,"ALDOB; ALDOC; ENO1; ENO2; ENO3; FBP1; FBP2; G6PC2; G6PC3; GAPDH; GOT1; GOT2; GPI; MDH1; MDH2; PC; PCK1; PCK2; PGAM1; SLC25A1; SLC25A10; SLC25A11; SLC25A12; SLC25A13; SLC37A1; SLC37A2; SLC37A4; TPI1"
"R-HSA-5693565","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks",0.320410374389237,0.207316143382205,0.12222155109497,41,"ABL1; APBB1; ATM; BABAM1; BAP1; BARD1; BAZ1B; BRCA1; CHEK2; EYA1; EYA2; EYA3; EYA4; FAM175A; H2AFX; H2BFS; HERC2; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; KAT5; KDM4A; KDM4B; MAPK8; MDC1; MRE11; NBN; PIAS4; PPP5C; RAD50; RNF168; RNF8; SMARCA5; SUMO1; TP53BP1; UBA52; UBC; UBE2I; UBE2N; UIMC1"
"R-HSA-397795","G-protein beta:gamma signalling",0.327623606145843,0.212116847440944,0.122456826368105,39,"AKT1; AKT2; AKT3; CSF2RB; GAB2; GNB1; GNB2; GNB3; GNB4; GNB5; GNG10; GNG11; GNG12; GNG2; GNG3; GNG4; GNG5; GNG7; GNGT2; GRB2; IL2RA; IL2RB; IL5; JAK1; JAK2; JAK3; PDPK1; PIK3CA; PIK3CB; PIK3CD; PIK3CG; PIK3R1; PIK3R2; PIK3R3; PIK3R5; PLCB1; PLCB2; PLCB3; SHC1"
"R-HSA-168643","Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways",-0.318470028555675,0.207131614353248,0.124164805839713,42,"AIM2; APP; BCL2; BCL2L1; BIRC2; BIRC3; CARD9; CASP1; CASP4; CASP8; CASP9; CHUK; CYLD; HSP90AB1; IKBKB; IRAK2; ITCH; MAP2K6; MAP3K7; MAPK11; MAPK12; MAPK13; MAPK14; MEFV; NLRC4; NLRP1; NLRP3; NOD1; NOD2; P2RX7; PANX1; PSTPIP1; PYCARD; RIPK2; SUGT1; TAB1; TAB2; TNFAIP3; TRAF6; TXN; UBE2N; UBE2V1"
"R-HSA-1461973","Defensins",-0.497630026346559,0.324110561318912,0.124692670171195,15,"ART1; CCR2; CCR6; CD4; DEFA3; DEFA4; DEFA5; DEFB1; DEFB119; DEFB124; DEFB132; DEFB134; PRSS3; TLR1; TLR2"
"R-HSA-3928664","Ephrin signaling",-0.472372768878748,0.308047088364557,0.125166646823055,17,"ARHGEF7; EFNB2; EFNB3; EPHB1; EPHB2; EPHB3; EPHB4; EPHB6; FYN; GIT1; MYL12A; NCK2; PAK1; PAK2; RAC1; SDCBP; SRC"
"R-HSA-8854214","TBC/RABGAPs",0.317100745073577,0.20749004422779,0.126445592722889,41,"ARF6; GABARAP; GABARAPL2; GGA1; GGA2; GGA3; MAP1LC3B; OPTN; POLG; RAB11A; RAB11B; RAB33B; RAB35; RAB4A; RAB5A; RAB5B; RAB5C; RAB6A; RAB6B; RAB7A; RAB8A; RAB8B; RABEP1; RABGAP1; RABGEF1; SYTL1; TBC1D10A; TBC1D10B; TBC1D10C; TBC1D13; TBC1D14; TBC1D15; TBC1D16; TBC1D17; TBC1D2; TBC1D20; TBC1D24; TBC1D7; TSC1; TSC2; ULK1"
"R-HSA-174824","Plasma lipoprotein assembly, remodeling, and clearance",-0.279337167502678,0.184516319267268,0.130054074990446,54,"A2M; ABCA1; ABCG1; ALB; AMN; ANGPTL3; ANGPTL4; ANGPTL8; AP2A1; AP2A2; AP2B1; AP2M1; AP2S1; APOA1; APOA2; APOB; APOC3; BMP1; CES3; CETP; CIDEC; CLTA; CLTC; CUBN; FURIN; HDLBP; LCAT; LDLR; LDLRAP1; LIPA; LIPC; LIPG; LMF1; LMF2; LPA; LPL; LSR; MBTPS1; MTTP; MYLIP; NCEH1; NPC1; NPC2; NR1H2; NR1H3; P4HB; PCSK5; PCSK6; PCSK9; PLTP; PRKACB; SAR1B; SCARB1; SOAT1"
"R-HSA-5620924","Intraflagellar transport",-0.323705508653324,0.214589166333241,0.13142928673709,39,"CLUAP1; DYNC2H1; DYNC2LI1; DYNLL1; DYNLL2; DYNLRB1; DYNLRB2; HSPB11; IFT122; IFT140; IFT172; IFT22; IFT27; IFT43; IFT46; IFT52; IFT57; IFT74; IFT80; IFT81; IFT88; KIF17; KIF3A; KIF3C; KIFAP3; TCTE3; TCTEX1D1; TCTEX1D2; TNPO1; TRAF3IP1; TRIP11; TTC21B; TTC26; TTC30A; TTC30B; WDR19; WDR34; WDR35; WDR60"
"R-HSA-1226099","Signaling by FGFR in disease",0.273207263222546,0.181279332515317,0.131783356902923,55,"BCR; CNTRL; CPSF6; CUX1; ERLIN2; FGF1; FGF10; FGF17; FGF18; FGF2; FGF20; FGF22; FGF5; FGF7; FGF9; FGFR1; FGFR1OP; FGFR1OP2; FGFR2; FGFR3; FGFR4; FRS2; GAB1; GAB2; GRB2; GTF2F1; GTF2F2; HRAS; KRAS; LRRFIP1; MYO18A; NCBP1; NCBP2; NRAS; PIK3CA; PIK3R1; PLCG1; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; SOS1; STAT1; STAT3; STAT5A; STAT5B; TRIM24; ZMYM2"
"R-HSA-1236394","Signaling by ERBB4",0.326556678012558,0.217778577767119,0.133746705727238,37,"ADAM17; APH1A; APH1B; BTC; CXCL12; EGF; EGFR; ERBB3; ERBB4; EREG; ESR1; GFAP; GRB2; HRAS; ITCH; KRAS; NCOR1; NCSTN; NEDD4; NRAS; NRG1; NRG4; PGR; PIK3CA; PIK3R1; PSEN1; PSEN2; S100B; SHC1; SOS1; STAT5A; TAB2; UBA52; UBC; WWOX; WWP1; YAP1"
"R-HSA-210500","Glutamate Neurotransmitter Release Cycle",-0.412187979899474,0.277488858347976,0.137432143034099,22,"ARL6IP5; CPLX1; GLS; PPFIA1; PPFIA2; PPFIA3; PPFIA4; RAB3A; RIMS1; SLC17A7; SLC1A1; SLC1A2; SLC1A3; SLC1A6; SLC1A7; SNAP25; STX1A; STXBP1; SYT1; TSPOAP1; UNC13B; VAMP2"
"R-HSA-6809371","Formation of the cornified envelope",-0.264322940227923,0.178642392508598,0.138974561321124,58,"CAPN1; CAPNS1; CASP14; CDSN; CELA2A; CSTA; DSC1; DSC2; DSC3; DSG1; DSG2; DSG3; DSP; EVPL; FLG; FURIN; IVL; JUP; KAZN; KLK12; KLK13; KLK14; KLK5; KLK8; LCE1A; LCE1C; LCE1D; LCE1E; LCE2A; LCE2B; LCE3A; LCE3C; LCE3D; LCE3E; LCE4A; LCE5A; LIPJ; LIPK; LIPM; LIPN; LOR; PCSK6; PERP; PI3; PKP1; PKP2; PKP3; PKP4; PPL; PRSS8; SPINK5; SPINK6; SPINK9; SPRR1B; SPRR2A; SPRR2B; SPRR2D; SPRR2E"
"R-HSA-350562","Regulation of ornithine decarboxylase (ODC)",0.300524712633822,0.203484090435178,0.139703684132148,43,"AZIN1; NQO1; OAZ1; OAZ2; OAZ3; ODC1; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; SEM1"
"R-HSA-68874","M/G1 Transition",0.261396506789743,0.177030610775277,0.139793335592243,58,"CDC45; CDC6; CDC7; CDK2; CDT1; DBF4; E2F1; E2F2; GMNN; MCM10; MCM2; MCM3; MCM4; MCM5; MCM6; MCM7; MCM8; ORC1; ORC3; ORC4; ORC5; ORC6; POLA2; POLE; POLE2; POLE3; POLE4; PRIM1; PRIM2; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6"
"R-HSA-69002","DNA Replication Pre-Initiation",0.261396506789743,0.177030610775277,0.139793335592243,58,"CDC45; CDC6; CDC7; CDK2; CDT1; DBF4; E2F1; E2F2; GMNN; MCM10; MCM2; MCM3; MCM4; MCM5; MCM6; MCM7; MCM8; ORC1; ORC3; ORC4; ORC5; ORC6; POLA2; POLE; POLE2; POLE3; POLE4; PRIM1; PRIM2; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6"
"R-HSA-8863795","Downregulation of ERBB2 signaling",0.390829536366104,0.264950606990307,0.140184751420585,24,"AKT1; AKT2; AKT3; BTC; CDC37; CUL5; EGF; EGFR; ERBB2; ERBB3; ERBB4; ERBIN; EREG; HSP90AA1; MATK; NRG1; NRG4; PTPN12; PTPN18; RNF41; STUB1; UBA52; UBC; USP8"
"R-HSA-4641257","Degradation of AXIN",0.292291807869606,0.199344657669817,0.14257649816356,45,"AXIN1; AXIN2; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; RNF146; SEM1; SMURF2; TNKS; TNKS2; UBA52; UBC"
"R-HSA-2022870","Chondroitin sulfate biosynthesis",-0.454788252687727,0.310293916252569,0.142738414278064,17,"BCAN; CHPF; CHPF2; CHST11; CHST12; CHST13; CHST15; CHST3; CHST9; CHSY1; CHSY3; CSGALNACT1; CSGALNACT2; CSPG4; CSPG5; DCN; VCAN"
"R-HSA-8939902","Regulation of RUNX2 expression and activity",0.260751055387303,0.178581065922372,0.144255143600135,57,"CBFB; CUL1; DLX5; DLX6; ESR1; ESRRA; FBXW7; GSK3B; HIVEP3; MSX2; NKX3-2; NR3C1; PPARGC1A; PPARGC1B; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; RUNX2; SEM1; SKP1; SKP2; SMURF1; STAT1; STUB1"
"R-HSA-1963640","GRB2 events in ERBB2 signaling",0.503278485085868,0.344906226985794,0.14451699461472,13,"BTC; EGF; EGFR; ERBB2; ERBB4; EREG; GRB2; HRAS; KRAS; NRAS; NRG1; NRG4; SOS1"
"R-HSA-5654699","SHC-mediated cascade:FGFR2",0.449587025489182,0.308212821073885,0.144650391145998,17,"FGF1; FGF10; FGF17; FGF18; FGF2; FGF20; FGF22; FGF5; FGF7; FGF9; FGFR2; GRB2; HRAS; KRAS; NRAS; SHC1; SOS1"
"R-HSA-1483213","Synthesis of PE",0.519829485169294,0.35643455837064,0.144726205034397,12,"CEPT1; CHKA; CHKB; ETNK1; ETNK2; ETNPPL; LPIN1; LPIN2; LPIN3; PHOSPHO1; PISD; SELENOI"
"R-HSA-380270","Recruitment of mitotic centrosome proteins and complexes",0.250344980018885,0.171682454668923,0.144789236408989,62,"ACTR1A; AKAP9; ALMS1; CCP110; CDK1; CDK11A; CDK11B; CDK5RAP2; CENPJ; CEP131; CEP135; CEP152; CEP164; CEP192; CEP250; CEP290; CEP41; CEP57; CEP63; CEP70; CEP72; CEP76; CEP78; CKAP5; CLASP1; CNTRL; CSNK1D; CSNK1E; DCTN1; DCTN2; DYNC1H1; DYNC1I2; DYNLL1; FGFR1OP; HAUS1; HAUS2; HAUS4; HAUS5; HAUS6; HAUS8; HSP90AA1; MAPRE1; MZT1; MZT2A; MZT2B; NDE1; NEDD1; NEK2; NINL; ODF2; PAFAH1B1; PCM1; PCNT; PLK1; PLK4; PPP2R1A; PRKAR2B; SDCCAG8; SFI1; SSNA1; TUBA1A; TUBA4A"
"R-HSA-380287","Centrosome maturation",0.250344980018885,0.171682454668923,0.144789236408989,62,"ACTR1A; AKAP9; ALMS1; CCP110; CDK1; CDK11A; CDK11B; CDK5RAP2; CENPJ; CEP131; CEP135; CEP152; CEP164; CEP192; CEP250; CEP290; CEP41; CEP57; CEP63; CEP70; CEP72; CEP76; CEP78; CKAP5; CLASP1; CNTRL; CSNK1D; CSNK1E; DCTN1; DCTN2; DYNC1H1; DYNC1I2; DYNLL1; FGFR1OP; HAUS1; HAUS2; HAUS4; HAUS5; HAUS6; HAUS8; HSP90AA1; MAPRE1; MZT1; MZT2A; MZT2B; NDE1; NEDD1; NEK2; NINL; ODF2; PAFAH1B1; PCM1; PCNT; PLK1; PLK4; PPP2R1A; PRKAR2B; SDCCAG8; SFI1; SSNA1; TUBA1A; TUBA4A"
"R-HSA-8957322","Metabolism of steroids",-0.260505022540311,0.178768721785588,0.145056177444803,58,"ABCC3; ACACB; ACAT2; ACOT8; ACOX2; AKR1B1; AKR1B15; AKR1C1; AKR1C2; AKR1C3; ALB; AMACR; ARV1; BAAT; CARM1; CGA; CH25H; CHD9; CUBN; CYP11A1; CYP11B1; CYP17A1; CYP19A1; CYP21A2; CYP24A1; CYP27A1; CYP27B1; CYP2R1; CYP39A1; CYP46A1; CYP51A1; CYP7A1; CYP7B1; CYP8B1; DHCR24; DHCR7; ELOVL6; FABP6; FASN; FDFT1; FDPS; FDX1; FDX2; FDXR; GC; GGPS1; GPAM; HMGCR; HMGCS1; HSD11B1; HSD17B1; HSD17B11; HSD17B12; HSD17B14; HSD17B2; HSD17B3; HSD17B4; HSD17B7"
"R-HSA-1251985","Nuclear signaling by ERBB4",0.408246444271323,0.281508517262303,0.1469999896256,21,"ADAM17; APH1A; APH1B; BTC; CXCL12; ERBB4; EREG; ESR1; GFAP; NCOR1; NCSTN; NRG1; NRG4; PGR; PSEN1; PSEN2; S100B; STAT5A; TAB2; WWOX; YAP1"
"R-HSA-2029482","Regulation of actin dynamics for phagocytic cup formation",0.364336879655477,0.251936502109296,0.148136350662903,27,"ABI1; ABL1; ACTG1; ACTR2; ACTR3; ARPC1A; ARPC1B; ARPC2; ARPC3; ARPC4; ARPC5; BAIAP2; BRK1; CD247; CDC42; CFL1; CRK; CYFIP2; DOCK1; ELMO1; ELMO2; FCGR1A; FCGR2A; FCGR3A; GRB2; HSP90AA1; HSP90AB1"
"R-HSA-380259","Loss of Nlp from mitotic centrosomes",0.25213980279386,0.174421289512809,0.148295240573656,60,"ACTR1A; AKAP9; ALMS1; CCP110; CDK1; CDK5RAP2; CENPJ; CEP131; CEP135; CEP152; CEP164; CEP192; CEP250; CEP290; CEP41; CEP57; CEP63; CEP70; CEP72; CEP76; CEP78; CKAP5; CLASP1; CNTRL; CSNK1D; CSNK1E; DCTN1; DCTN2; DYNC1H1; DYNC1I2; DYNLL1; FGFR1OP; HAUS1; HAUS2; HAUS4; HAUS5; HAUS6; HAUS8; HSP90AA1; MAPRE1; NDE1; NEDD1; NEK2; NINL; ODF2; PAFAH1B1; PCM1; PCNT; PLK1; PLK4; PPP2R1A; PRKAR2B; SDCCAG8; SFI1; SSNA1; TUBA1A; TUBA4A; TUBB4A; TUBG1; YWHAE"
"R-HSA-380284","Loss of proteins required for interphase microtubule organization from the centrosome",0.25213980279386,0.174421289512809,0.148295240573656,60,"ACTR1A; AKAP9; ALMS1; CCP110; CDK1; CDK5RAP2; CENPJ; CEP131; CEP135; CEP152; CEP164; CEP192; CEP250; CEP290; CEP41; CEP57; CEP63; CEP70; CEP72; CEP76; CEP78; CKAP5; CLASP1; CNTRL; CSNK1D; CSNK1E; DCTN1; DCTN2; DYNC1H1; DYNC1I2; DYNLL1; FGFR1OP; HAUS1; HAUS2; HAUS4; HAUS5; HAUS6; HAUS8; HSP90AA1; MAPRE1; NDE1; NEDD1; NEK2; NINL; ODF2; PAFAH1B1; PCM1; PCNT; PLK1; PLK4; PPP2R1A; PRKAR2B; SDCCAG8; SFI1; SSNA1; TUBA1A; TUBA4A; TUBB4A; TUBG1; YWHAE"
"R-HSA-8982491","Glycogen metabolism",0.406568409116402,0.281663844202108,0.148893014977661,21,"AGL; CALM1; EPM2A; GAA; GBE1; GYG1; GYS1; GYS2; NHLRC1; PGM1; PGM2; PGM2L1; PHKG1; PHKG2; PPP1R3C; PYGB; PYGL; PYGM; UBA52; UBC; UGP2"
"R-HSA-1266695","Interleukin-7 signaling",0.424683517069433,0.294232985034634,0.148919664070147,19,"BRWD1; CISH; HGF; IL7; IRS1; IRS2; JAK1; JAK3; PIK3R1; PIK3R2; PIK3R3; RAG1; SMARCA4; SOCS1; SOCS2; STAT3; STAT5A; STAT5B; TSLP"
"R-HSA-2046104","alpha-linolenic (omega3) and linoleic (omega6) acid metabolism",0.515241781465507,0.357122057223915,0.149087804926783,12,"ACAA1; ACOT8; ACOX1; ACSL1; ELOVL1; ELOVL2; ELOVL3; ELOVL5; FADS1; FADS2; HSD17B4; SCP2"
"R-HSA-2046106","alpha-linolenic acid (ALA) metabolism",0.515241781465507,0.357122057223915,0.149087804926783,12,"ACAA1; ACOT8; ACOX1; ACSL1; ELOVL1; ELOVL2; ELOVL3; ELOVL5; FADS1; FADS2; HSD17B4; SCP2"
"R-HSA-6783310","Fanconi Anemia Pathway",-0.344869513083025,0.23909456434212,0.14919013757631,31,"ATR; ATRIP; DCLRE1A; DCLRE1B; EME1; EME2; ERCC4; FAAP100; FAAP20; FAAP24; FAN1; FANCA; FANCC; FANCD2; FANCE; FANCF; FANCG; FANCI; FANCL; FANCM; MUS81; RPA1; RPA2; RPA3; SLX1A; SLX4; UBA52; UBC; UBE2T; USP1; WDR48"
"R-HSA-3656237","Defective EXT2 causes exostoses 2",0.553232925258846,0.384572459829018,0.150273481041873,10,"AGRN; GPC1; GPC2; GPC5; GPC6; HSPG2; SDC1; SDC2; SDC3; SDC4"
"R-HSA-3656253","Defective EXT1 causes exostoses 1, TRPS2 and CHDS",0.553232925258846,0.384572459829018,0.150273481041873,10,"AGRN; GPC1; GPC2; GPC5; GPC6; HSPG2; SDC1; SDC2; SDC3; SDC4"
"R-HSA-192105","Synthesis of bile acids and bile salts",-0.348524295048653,0.242765482563211,0.15110426974155,30,"ACOT8; ACOX2; AKR1C1; AKR1C2; AKR1C3; AMACR; BAAT; CH25H; CYP27A1; CYP39A1; CYP46A1; CYP7A1; CYP7B1; CYP8B1; HSD17B4; HSD3B7; NCOA1; NCOA2; NR1H4; OSBPL1A; OSBPL2; OSBPL3; OSBPL6; OSBPL7; OSBPL9; PTGIS; RXRA; SCP2; SLC27A2; SLC27A5"
"R-HSA-69601","Ubiquitin Mediated Degradation of Phosphorylated Cdc25A",0.291331163695518,0.203926774623006,0.153117297266401,43,"ATM; CDC25A; CHEK1; CHEK2; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; SEM1; UBA52; UBC"
"R-HSA-69610","p53-Independent DNA Damage Response",0.291331163695518,0.203926774623006,0.153117297266401,43,"ATM; CDC25A; CHEK1; CHEK2; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; SEM1; UBA52; UBC"
"R-HSA-69613","p53-Independent G1/S DNA damage checkpoint",0.291331163695518,0.203926774623006,0.153117297266401,43,"ATM; CDC25A; CHEK1; CHEK2; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; SEM1; UBA52; UBC"
"R-HSA-5357905","Regulation of TNFR1 signaling",-0.374075561378189,0.263741615561615,0.156091215783851,25,"BIRC2; BIRC3; CASP8; CHUK; CLIP3; CYLD; IKBKB; MADD; OTULIN; RACK1; RBCK1; RIPK1; RNF31; SHARPIN; SPPL2A; TAX1BP1; TNF; TNFAIP3; TNFRSF1A; TRAF1; TRAF2; UBA52; UBC; USP2; USP4"
"R-HSA-1660662","Glycosphingolipid metabolism",0.306224791753496,0.21602972127894,0.156333194462619,38,"ARSA; ARSB; ARSG; ARSI; ARSJ; ARSK; ASAH1; ASAH2; B3GALNT1; B4GALNT1; CERK; CPTP; CTSA; ENPP7; ESYT1; ESYT2; ESYT3; GALC; GBA; GBA2; GLB1; GLB1L; GLTP; GM2A; HEXA; HEXB; NEU1; NEU3; NEU4; PSAP; SMPD1; SMPD2; SMPD3; SMPD4; SUMF1; SUMF2; UGCG; UGT8"
"R-HSA-8849471","PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases",0.49113749331177,0.346599862137805,0.156478297635317,13,"ARHGAP35; BCAR1; CRK; DOCK1; ELMO1; ELMO2; HRAS; KRAS; NRAS; PTK6; PXN; RAC1; RASA1"
"R-HSA-499943","Interconversion of nucleotide di- and triphosphates",0.340917057261802,0.240704441698984,0.156678743680014,30,"AK1; AK2; AK4; AK5; AK6; AK7; AK8; AK9; CMPK1; CTPS1; DCTD; DCTPP1; DTYMK; DUT; GLRX; GSR; GUK1; NME1; NME2; NME3; NME4; NME6; NME7; NUDT13; RRM1; RRM2; RRM2B; TXN; TXNRD1; TYMS"
"R-HSA-212436","Generic Transcription Pathway",0.255418005385767,0.180346267388745,0.156698095100781,56,"ABL1; ACTL6A; AGO1; AGO2; AGO3; AGO4; AIFM2; AKT1; AKT2; AKT3; APAF1; ARID1B; ARID2; ARID3A; ATAD2; ATF2; ATM; ATR; ATRIP; AURKA; AURKB; AUTS2; AXIN1; BANP; BARD1; BAX; BBC3; BCL2L11; BCL2L14; BGLAP; BID; BIRC5; BLK; BLM; BMI1; BNIP3L; BRCA1; BRD2; BRD7; BRIP1; BRPF3; CARM1; CASP1; CASP10; CASP6; CBFB; CBX2; CBX3; CBX4; CBX5; CBX6; CBX8; CCNA1; CCNA2; CCNB1; CCNC"
"R-HSA-8878166","Transcriptional regulation by RUNX2",0.252772895951124,0.17887251604788,0.157612939306274,57,"ABL1; AKT1; AKT2; AKT3; BAX; BGLAP; CBFB; CCNB1; CCND1; CDK1; CDK4; COL1A1; CUL1; DLX5; DLX6; ESR1; ESRRA; FBXW7; GLI2; GLI3; GSK3B; HAND2; HDAC3; HDAC4; HES1; HEY1; HEY2; HIVEP3; IHH; ITGA5; ITGBL1; LGALS3; MAF; MAPK1; MAPK3; MSX2; NKX3-2; NR3C1; PPARGC1A; PPARGC1B; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3"
"R-HSA-416700","Other semaphorin interactions",-0.440481613584796,0.312053474683127,0.158080113433746,17,"CD72; ITGA1; ITGB1; PLXNA1; PLXNA2; PLXNA4; PLXNC1; PLXND1; PTPRC; SEMA3E; SEMA4A; SEMA4D; SEMA5A; SEMA6A; SEMA6D; SEMA7A; TREM2"
"R-HSA-390666","Serotonin receptors",0.524093165934261,0.371503116242169,0.158322197260262,11,"HTR1A; HTR1B; HTR1D; HTR1E; HTR1F; HTR2A; HTR2B; HTR4; HTR5A; HTR6; HTR7"
"R-HSA-6807878","COPI-mediated anterograde transport",-0.240526773854331,0.170884524480388,0.159267376388008,64,"ACTR10; ACTR1A; ANK1; ANK2; ANK3; ARCN1; ARF3; ARF4; ARF5; ARFGAP1; ARFGAP2; ARFGAP3; BET1; BET1L; CAPZA1; CAPZA2; CAPZA3; CAPZB; CD55; CD59; COG1; COG2; COG3; COG4; COG5; COG6; COG7; COG8; COPA; COPB1; COPB2; COPE; COPG1; COPG2; COPZ1; COPZ2; DCTN1; DCTN2; DCTN4; DCTN5; DCTN6; DYNC1H1; DYNC1I1; DYNC1I2; DYNC1LI1; DYNC1LI2; DYNLL1; DYNLL2; FOLR1; GBF1; GOLGA2; GOLGB1; GORASP1; GOSR1; GOSR2; KDELR1; KDELR2; KDELR3; NAPA; NAPB; NAPG; NSF; RAB1A; SPTA1"
"R-HSA-6807505","RNA polymerase II transcribes snRNA genes",0.251446666827803,0.178920248292336,0.15991540659057,57,"CCNK; CCNT1; CCNT2; CDK7; CDK9; ELL; ELL2; ELL3; GTF2A1; GTF2A2; GTF2B; GTF2E1; GTF2E2; GTF2F1; GTF2F2; ICE1; ICE2; INTS1; INTS10; INTS12; INTS2; INTS3; INTS4; INTS5; INTS6; INTS7; INTS8; INTS9; NABP1; NABP2; NCBP1; NCBP2; PHAX; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; POU2F1; POU2F2; RPAP2; RPRD1A; RPRD1B; RPRD2; SNAPC1; SNAPC2; SNAPC3; SNAPC4; SNAPC5; SP1; SRRT"
"R-HSA-5223345","Miscellaneous transport and binding events",-0.392430545948521,0.279355828095094,0.160089832464861,22,"ADD1; ADD2; ADD3; ANKH; AZGP1; CTNS; DMTN; LRRC8A; LRRC8B; LRRC8C; LRRC8D; LRRC8E; MRS2; NIPA1; NIPA2; NIPAL1; NIPAL2; NIPAL3; NIPAL4; PIP; PQLC2; TUSC3"
"R-HSA-425393","Transport of inorganic cations/anions and amino acids/oligopeptides",-0.253348816508183,0.18054353448965,0.160540483330339,57,"AHCYL2; CALM1; CTNS; SLC12A1; SLC12A2; SLC12A4; SLC12A5; SLC12A6; SLC12A7; SLC15A1; SLC15A2; SLC15A3; SLC15A4; SLC16A10; SLC17A1; SLC17A5; SLC17A7; SLC1A1; SLC1A2; SLC1A3; SLC1A4; SLC1A5; SLC1A6; SLC1A7; SLC20A1; SLC20A2; SLC24A1; SLC24A2; SLC24A3; SLC24A4; SLC25A10; SLC25A18; SLC25A22; SLC25A26; SLC25A29; SLC26A1; SLC26A11; SLC26A2; SLC26A3; SLC26A4; SLC26A6; SLC26A7; SLC26A9; SLC34A1; SLC34A2; SLC34A3; SLC36A1; SLC36A2; SLC36A4; SLC38A1; SLC38A4; SLC3A1; SLC43A1; SLC43A2; SLC4A2; SLC4A3; SLC4A4"
"R-HSA-2142691","Synthesis of Leukotrienes (LT) and Eoxins (EX)",-0.417514851100186,0.297851153271896,0.16098791120868,19,"ABCC1; ALOX15; ALOX5; ALOX5AP; CYP4A11; CYP4A22; CYP4B1; CYP4F11; CYP4F2; CYP4F22; CYP4F3; DPEP1; DPEP2; DPEP3; GGT1; GGT5; LTA4H; MAPKAPK2; PTGR1"
"R-HSA-68867","Assembly of the pre-replicative complex",0.252673571051794,0.180446674555608,0.161433300291985,56,"CDC6; CDT1; E2F1; E2F2; GMNN; MCM2; MCM3; MCM4; MCM5; MCM6; MCM7; MCM8; ORC1; ORC3; ORC4; ORC5; ORC6; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; SEM1; UBA52; UBC"
"R-HSA-383280","Nuclear Receptor transcription pathway",-0.301115028260662,0.215744416696199,0.162804092071137,39,"ESR1; ESR2; ESRRA; ESRRB; ESRRG; HNF4G; NR0B2; NR1D1; NR1D2; NR1H2; NR1H3; NR1H4; NR1I2; NR1I3; NR2C1; NR2C2; NR2C2AP; NR2F1; NR2F6; NR3C1; NR4A2; NR5A2; NR6A1; NRBF2; NRBP1; PGR; PPARA; PPARD; PPARG; RARA; RARB; RORA; RORB; RORC; RXRA; RXRB; RXRG; THRB; VDR"
"R-HSA-180786","Extension of Telomeres",-0.367750283540267,0.264249010210145,0.164019067913149,25,"DNA2; LIG1; NHP2; PCNA; POLA2; POLD1; POLD2; POLD3; POLE; POLE2; POLE3; POLE4; PRIM1; PRIM2; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3; RUVBL1; RUVBL2; TERT"
"R-HSA-5218920","VEGFR2 mediated vascular permeability",0.357377477668251,0.257217275152472,0.164711391844783,26,"AKT1; AKT2; AKT3; CALM1; CAV1; CDH5; CTNNA1; CTNNB1; CTNND1; HSP90AA1; JUP; MAPKAP1; MLST8; MTOR; NOS3; PAK1; PAK2; PDPK1; PRR5; RAC1; RICTOR; THEM4; TRIB3; VAV1; VAV2; VAV3"
"R-HSA-2453902","The canonical retinoid cycle in rods (twilight vision)",0.400802911793295,0.289129489691733,0.165673580466049,20,"ABCA4; CYP4V2; DHRS9; HSD17B1; HSD17B6; LRAT; MYO7A; NAPEPLD; RBP1; RBP4; RDH10; RDH11; RDH12; RDH16; RDH5; RLBP1; RPE65; SDR9C7; STRA6; TTR"
"R-HSA-1170546","Prolactin receptor signaling",0.536195150903903,0.387487736365424,0.166427906884041,10,"BTRC; CUL1; GHR; JAK2; PRL; PRLR; SH2B1; SKP1; STAT5A; STAT5B"
"R-HSA-1474244","Extracellular matrix organization",-0.240976005178834,0.17496953716614,0.168436363267745,61,"A2M; ACAN; ACTN1; ADAM10; ADAM12; ADAM15; ADAM17; ADAM19; ADAM8; ADAM9; ADAMTS14; ADAMTS16; ADAMTS18; ADAMTS2; ADAMTS3; ADAMTS4; ADAMTS5; ADAMTS8; ADAMTS9; AGRN; ASPN; BCAN; BMP1; BMP4; BMP7; BSG; CAPN1; CAPN10; CAPN11; CAPN12; CAPN13; CAPN14; CAPN15; CAPN2; CAPN3; CAPN5; CAPN7; CAPN8; CAPN9; CAPNS1; CAPNS2; CASP3; CAST; CD151; CD44; CD47; CDH1; CEACAM1; CEACAM6; CMA1; COL10A1; COL11A1; COL11A2; COL12A1; COL13A1; COL14A1; COL15A1; COL16A1; COL17A1; COL18A1; COL19A1"
"R-HSA-1655829","Regulation of cholesterol biosynthesis by SREBP (SREBF)",0.269962173417524,0.196082509741169,0.168580756115865,47,"ACACB; CARM1; CHD9; CYP51A1; DHCR7; ELOVL6; FASN; FDFT1; FDPS; GGPS1; GPAM; HMGCR; HMGCS1; IDI1; INSIG1; INSIG2; KPNB1; LSS; MBTPS1; MTF1; MVD; MVK; NCOA1; NCOA2; NCOA6; NFYA; NFYB; NFYC; PMVK; PPARA; RAN; RXRA; SAR1B; SC5D; SCAP; SCD; SEC24A; SEC24B; SEC24C; SEC24D; SMARCD3; SP1; SQLE; SREBF1; SREBF2; TBL1XR1; TGS1"
"R-HSA-5610787","Hedgehog 'off' state",0.244417299397619,0.177637163203863,0.168841567646361,58,"ADCY1; ADCY10; ADCY2; ADCY3; ADCY4; ADCY5; ADCY6; ADCY7; ADCY9; BTRC; CSNK1A1; CUL1; DYNC2H1; FUZ; GLI1; GLI2; GLI3; GNAS; GPR161; GSK3B; IFT122; IFT140; IFT172; IFT52; IFT57; IFT88; INTU; ITCH; KIF3A; KIF7; MKS1; NUMB; PRKACB; PRKAR1A; PRKAR1B; PRKAR2A; PRKAR2B; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1"
"R-HSA-8878159","Transcriptional regulation by RUNX3",0.246250185283269,0.179105298067065,0.169165373354076,57,"BCL2L11; BRD2; CARM1; CBFB; CCND1; CDKN2A; CHD9; CTGF; CTNNB1; EP300; FOXO3; HDAC4; HES1; ITGA4; JAG1; KAT2A; KAT2B; KRAS; LEF1; MAML1; MAML2; MAML3; MDM2; MYC; NCOA1; NCOA2; NCOA6; NOTCH1; PPARA; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5"
"R-HSA-532668","N-glycan trimming in the ER and Calnexin/Calreticulin cycle",-0.320403102234141,0.233285769025672,0.169616806298877,33,"AMFR; CALR; CANX; DERL1; DERL2; EDEM1; EDEM2; EDEM3; ENGASE; GANAB; MAN1B1; MARCH6; MLEC; MOGS; NGLY1; OS9; PDIA3; PRKCSH; PSMC1; RAD23B; RNF103; RNF139; RNF185; RNF5; SEL1L; SYVN1; TRIM13; UBA52; UBC; UBXN1; UGGT1; UGGT2; VCP"
"R-HSA-901042","Calnexin/calreticulin cycle",-0.369567594991427,0.269503361269095,0.170284189380173,24,"AMFR; CALR; CANX; DERL2; EDEM1; EDEM2; EDEM3; GANAB; MAN1B1; MARCH6; OS9; PDIA3; PRKCSH; RNF103; RNF139; RNF185; RNF5; SEL1L; SYVN1; TRIM13; UBA52; UBC; UGGT1; UGGT2"
"R-HSA-69473","G2/M DNA damage checkpoint",0.256388699158512,0.187050418523726,0.170470678127095,52,"ATM; ATR; ATRIP; BABAM1; BARD1; BLM; BRCA1; BRIP1; CCNB1; CDK1; CHEK1; CHEK2; DNA2; EXO1; FAM175A; H2AFX; H2BFS; HERC2; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HUS1; KAT5; MDC1; MRE11; NBN; PIAS4; RAD1; RAD17; RAD50; RAD9A; RAD9B; RBBP8; RFC2; RFC3; RFC4; RFC5; RHNO1; RMI1; RMI2; RNF168; RNF8; RPA1; RPA2; RPA3; SFN; SUMO1; TOP3A; TOPBP1; TP53BP1; UBE2N"
"R-HSA-5362768","Hh mutants that don't undergo autocatalytic processing are degraded by ERAD",0.27133471454234,0.198121993166776,0.170832558219489,46,"DERL2; ERLEC1; OS9; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; SEL1L; SEM1; SHH; SYVN1; UBA52; UBC; VCP"
"R-HSA-4608870","Asymmetric localization of PCP proteins",0.251573072292903,0.183758670676927,0.170986598622992,54,"DVL2; FZD1; FZD2; FZD3; FZD4; FZD5; FZD7; FZD8; PARD6A; PRICKLE1; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; SCRIB; SEM1; SMURF1; SMURF2; UBA52; UBC; VANGL2; WNT5A"
"R-HSA-5654716","Downstream signaling of activated FGFR4",0.395203443293452,0.289651762089078,0.172438907053991,20,"FGF1; FGF17; FGF18; FGF2; FGF20; FGF9; FGFR4; FRS2; FRS3; GAB1; GRB2; HRAS; KLB; KRAS; NRAS; PIK3CA; PIK3R1; PLCG1; SHC1; SOS1"
"R-HSA-5688426","Deubiquitination",0.275191374051377,0.202359378486871,0.173857105404557,44,"ACTL6A; ACTR5; ACTR8; ADRB2; ADRM1; APC; ARRB1; ARRB2; ASXL2; ATXN3; ATXN7; AXIN1; AXIN2; BABAM1; BAP1; BARD1; BECN1; BIRC2; BIRC3; BRCA1; CCNA1; CCNA2; CCP110; CDC25A; CDK1; CFTR; CYLD; DDB2; DDX58; EP300; ESR1; FAM175A; FKBP8; FOXK1; FOXK2; GATA3; HGS; HIF1A; HIST1H2AG; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HIST2H2AA3"
"R-HSA-162582","Signal Transduction",-0.242198240904425,0.179345079279953,0.176868681329188,58,"A2M; ABCA4; ABHD12; ABHD6; ABI1; ABL1; ABR; ACKR1; ACKR3; ACKR4; ACTG1; ACTN2; ACTR2; ACTR3; ACVR1B; ACVR1C; ACVR2A; ACVR2B; ACVRL1; ADAM10; ADAM12; ADAM17; ADCY1; ADCY10; ADCY2; ADCY3; ADCY4; ADCY5; ADCY6; ADCY7; ADCY9; ADCYAP1; ADCYAP1R1; ADGRE1; ADGRE2; ADH1A; ADH4; ADM; ADM2; ADORA1; ADORA2A; ADORA2B; ADRA1A; ADRA1B; ADRA1D; ADRA2A; ADRA2C; ADRB1; ADRB2; AES; AGO1; AGO2; AGO3; AGO4; AGRN; AGT; AGTR1; AHCTF1"
"R-HSA-73728","RNA Polymerase I Promoter Opening",0.456937584117472,0.338501426617743,0.177053266418998,14,"H2AFJ; H2AFV; H2AFX; H2AFZ; H2BFS; H3F3A; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HIST2H2AA3; HIST2H2AC; MAPK3; MBD2"
"R-HSA-166663","Initial triggering of complement",0.430210041747034,0.319836948849901,0.178595606591177,16,"C1QA; C1QB; C1QC; C1S; C2; C3; C4A; C4B; CFB; CFD; COLEC10; COLEC11; FCN1; FCN2; FCN3; GZMM"
"R-HSA-68827","CDT1 association with the CDC6:ORC:origin complex",0.261243521381647,0.194411178095966,0.179023417993025,48,"CDC6; CDT1; GMNN; MCM8; ORC1; ORC3; ORC4; ORC5; ORC6; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; SEM1; UBA52; UBC"
"R-HSA-5654687","Downstream signaling of activated FGFR1",0.352127482216342,0.262667705063402,0.180056347059483,25,"FGF1; FGF10; FGF17; FGF2; FGF20; FGF22; FGF5; FGF9; FGFR1; FLRT1; FLRT2; FLRT3; FRS2; FRS3; GAB1; GRB2; HRAS; KL; KRAS; NRAS; PIK3CA; PIK3R1; PLCG1; SHC1; SOS1"
"R-HSA-450385","Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA",0.42699763038661,0.320195116106366,0.182349910782805,16,"AKT1; DCP2; DIS3; EXOSC1; EXOSC2; EXOSC3; EXOSC4; EXOSC5; EXOSC6; EXOSC7; EXOSC8; EXOSC9; MAPKAPK2; XRN1; YWHAB; ZFP36L1"
"R-HSA-392499","Metabolism of proteins",-0.241005461136232,0.180928662761479,0.182844783333543,57,"A4GNT; AARS; AARS2; ABCA3; ACADVL; ACE; ACHE; ACO2; ACTL6A; ACTR10; ACTR1A; ACTR5; ACTR8; ADAM10; ADAMTS10; ADAMTS12; ADAMTS13; ADAMTS14; ADAMTS15; ADAMTS16; ADAMTS17; ADAMTS18; ADAMTS19; ADAMTS2; ADAMTS3; ADAMTS4; ADAMTS5; ADAMTS6; ADAMTS7; ADAMTS8; ADAMTS9; ADAMTSL1; ADAMTSL2; ADAMTSL3; ADAMTSL4; ADAMTSL5; ADD1; ADGRF5; ADORA2A; ADORA2B; ADRA2A; ADRA2C; ADRB2; ADRM1; AGBL2; AGBL3; AGBL4; AGBL5; AGT; AGTPBP1; AIMP1; AIMP2; ALB; ALG1; ALG10; ALG11; ALG12"
"R-HSA-74752","Signaling by Insulin receptor",0.235769582336792,0.177933271163388,0.185156243131097,58,"AKT2; ATP6V0A1; ATP6V0A2; ATP6V0A4; ATP6V0B; ATP6V0C; ATP6V0D1; ATP6V0D2; ATP6V0E1; ATP6V0E2; ATP6V1A; ATP6V1B1; ATP6V1B2; ATP6V1C1; ATP6V1C2; ATP6V1D; ATP6V1E1; ATP6V1E2; ATP6V1F; ATP6V1G1; ATP6V1G2; ATP6V1H; FGF1; FGF10; FGF17; FGF18; FGF2; FGF20; FGF22; FGF5; FGF7; FGF9; FGFR1; FGFR2; FGFR3; FGFR4; FRS2; GAB1; GRB10; GRB2; HRAS; INSR; IRS1; IRS2; KL; KLB; KRAS; MAPK1; MAPK3; NRAS; PDE3B; PDPK1; PIK3C3; PIK3CA; PIK3CB; PIK3R1; PIK3R2; PIK3R4"
"R-HSA-6783783","Interleukin-10 signaling",-0.286339005762509,0.216448414893335,0.185869560839605,39,"CCL19; CCL2; CCL20; CCL22; CCR1; CCR2; CCR5; CD80; CD86; CSF1; CSF3; CXCL1; CXCL10; CXCL2; CXCL8; FCER2; FPR1; ICAM1; IL10; IL10RA; IL10RB; IL12A; IL13; IL18; IL1A; IL1B; IL1R1; IL1R2; IL1RN; IL4; JAK1; LIF; PTAFR; PTGS2; STAT3; TNF; TNFRSF1A; TNFRSF1B; TYK2"
"R-HSA-111933","Calmodulin induced events",-0.386792579074795,0.293433681330437,0.187450049606794,20,"ADCY1; ADCY2; ADCY3; ADCY4; ADCY5; ADCY6; ADCY7; ADCY9; CALM1; CAMK4; PDE1A; PDE1B; PDE1C; PRKACB; PRKAR1A; PRKAR1B; PRKAR2A; PRKAR2B; PRKCA; PRKCD"
"R-HSA-111997","CaM pathway",-0.386792579074795,0.293433681330437,0.187450049606794,20,"ADCY1; ADCY2; ADCY3; ADCY4; ADCY5; ADCY6; ADCY7; ADCY9; CALM1; CAMK4; PDE1A; PDE1B; PDE1C; PRKACB; PRKAR1A; PRKAR1B; PRKAR2A; PRKAR2B; PRKCA; PRKCD"
"R-HSA-167161","HIV Transcription Initiation",0.285973871744438,0.21707503630248,0.187705786417881,38,"CCNH; CDK7; ERCC3; GTF2A1; GTF2A2; GTF2B; GTF2E1; GTF2E2; GTF2F1; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; GTF2H5; MNAT1; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; TAF10; TAF11; TAF13; TAF2; TAF3; TAF4; TAF4B; TAF5; TAF6; TAF7; TBP"
"R-HSA-167162","RNA Polymerase II HIV Promoter Escape",0.285973871744438,0.21707503630248,0.187705786417881,38,"CCNH; CDK7; ERCC3; GTF2A1; GTF2A2; GTF2B; GTF2E1; GTF2E2; GTF2F1; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; GTF2H5; MNAT1; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; TAF10; TAF11; TAF13; TAF2; TAF3; TAF4; TAF4B; TAF5; TAF6; TAF7; TBP"
"R-HSA-73776","RNA Polymerase II Promoter Escape",0.285973871744438,0.21707503630248,0.187705786417881,38,"CCNH; CDK7; ERCC3; GTF2A1; GTF2A2; GTF2B; GTF2E1; GTF2E2; GTF2F1; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; GTF2H5; MNAT1; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; TAF10; TAF11; TAF13; TAF2; TAF3; TAF4; TAF4B; TAF5; TAF6; TAF7; TBP"
"R-HSA-73779","RNA Polymerase II Transcription Pre-Initiation And Promoter Opening",0.285973871744438,0.21707503630248,0.187705786417881,38,"CCNH; CDK7; ERCC3; GTF2A1; GTF2A2; GTF2B; GTF2E1; GTF2E2; GTF2F1; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; GTF2H5; MNAT1; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; TAF10; TAF11; TAF13; TAF2; TAF3; TAF4; TAF4B; TAF5; TAF6; TAF7; TBP"
"R-HSA-75953","RNA Polymerase II Transcription Initiation",0.285973871744438,0.21707503630248,0.187705786417881,38,"CCNH; CDK7; ERCC3; GTF2A1; GTF2A2; GTF2B; GTF2E1; GTF2E2; GTF2F1; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; GTF2H5; MNAT1; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; TAF10; TAF11; TAF13; TAF2; TAF3; TAF4; TAF4B; TAF5; TAF6; TAF7; TBP"
"R-HSA-76042","RNA Polymerase II Transcription Initiation And Promoter Clearance",0.285973871744438,0.21707503630248,0.187705786417881,38,"CCNH; CDK7; ERCC3; GTF2A1; GTF2A2; GTF2B; GTF2E1; GTF2E2; GTF2F1; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; GTF2H5; MNAT1; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; TAF10; TAF11; TAF13; TAF2; TAF3; TAF4; TAF4B; TAF5; TAF6; TAF7; TBP"
"R-HSA-69273","Cyclin A/B1/B2 associated events during G2/M transition",0.359405485788057,0.273194008891492,0.188318846463006,23,"CCNA1; CCNA2; CCNB1; CCNB2; CCNH; CDC25A; CDC25B; CDK1; CDK2; CDK7; FOXM1; LCMT1; MNAT1; PKMYT1; PLK1; PPME1; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R2A; WEE1; XPO1"
"R-HSA-4420097","VEGFA-VEGFR2 Pathway",0.226664067657635,0.172458485699028,0.188741600451369,62,"ABI1; AHCYL1; AKT1; AKT2; AKT3; AXL; BAIAP2; BCAR1; BRK1; CALM1; CAV1; CDC42; CDH5; CRK; CTNNA1; CTNNB1; CTNND1; CYBA; CYFIP2; DOCK1; ELMO1; ELMO2; FYN; HRAS; HSP90AA1; HSPB1; ITGAV; ITGB3; ITPR1; ITPR2; ITPR3; JUP; KDR; KRAS; MAPK11; MAPK12; MAPK13; MAPK14; MAPKAP1; MAPKAPK2; MAPKAPK3; MLST8; MTOR; NCF1; NCF2; NCF4; NCK1; NCK2; NCKAP1; NCKAP1L; NOS3; NRAS; PAK1; PAK2; PDPK1; PIK3CA; PIK3CB; PIK3R1; PIK3R2; PLCG1; PRKACB; PRKCA"
"R-HSA-1474165","Reproduction",0.268498772305472,0.204977149707817,0.190230981209164,43,"ACD; ACR; ADAM20; ADAM21; ATM; ATR; B4GALT1; BLM; BRCA1; BRCA2; CATSPER1; CATSPER2; CATSPER3; CATSPER4; CATSPERB; CATSPERD; CATSPERG; CD9; CDK2; CDK4; DIDO1; DMC1; H2AFJ; H2AFV; H2AFX; H2AFZ; H2BFS; H3F3A; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HIST2H2AA3; HIST2H2AC; HSPA2; IZUMO1; IZUMO4; LMNA; LMNB1; MLH1; MLH3; MND1; MRE11"
"R-HSA-1234174","Regulation of Hypoxia-inducible Factor (HIF) by oxygen",0.238650150377566,0.182564264274096,0.19114080791322,55,"AJUBA; ARNT; CA9; CITED2; CUL2; EGLN1; EGLN2; EGLN3; ELOC; EP300; EPAS1; EPO; HIF1A; HIF1AN; HIF3A; HIGD1A; LIMD1; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; SEM1; UBA52"
"R-HSA-2262749","Cellular response to hypoxia",0.238650150377566,0.182564264274096,0.19114080791322,55,"AJUBA; ARNT; CA9; CITED2; CUL2; EGLN1; EGLN2; EGLN3; ELOC; EP300; EPAS1; EPO; HIF1A; HIF1AN; HIF3A; HIGD1A; LIMD1; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; SEM1; UBA52"
"R-HSA-5654712","FRS-mediated FGFR4 signaling",0.431296429034655,0.330136546609949,0.191410342798864,15,"FGF1; FGF17; FGF18; FGF2; FGF20; FGF9; FGFR4; FRS2; FRS3; GRB2; HRAS; KLB; KRAS; NRAS; SOS1"
"R-HSA-9006936","Signaling by TGF-beta family members",0.234346901971431,0.179517243944829,0.191747025509818,57,"ACVR1B; ACVR1C; ACVR2A; ACVR2B; ACVRL1; AMH; AMHR2; ARHGEF18; BAMBI; BMPR1A; BMPR1B; BMPR2; CBL; CCNC; CCNK; CCNT1; CCNT2; CDK8; CDK9; CDKN2B; CER1; CGN; DRAP1; E2F4; E2F5; F11R; FKBP1A; FST; FSTL1; FSTL3; FURIN; GREM2; HDAC1; INHBA; INHBB; JUNB; MEN1; MTMR4; MYC; NCOR1; NEDD4L; NEDD8; NOG; PARD3; PARD6A; PARP1; PMEPA1; PPM1A; PPP1CB; PPP1R15A; PRKCZ; RBL1; RNF111; SERPINE1; SKI; SKIL; SMAD1"
"R-HSA-174403","Glutathione synthesis and recycling",-0.476162771909346,0.365496675971052,0.192648934761448,12,"CHAC1; CHAC2; CNDP2; GCLC; GCLM; GGCT; GGT1; GGT5; GGT6; GGT7; GSS; OPLAH"
"R-HSA-6784531","tRNA processing in the nucleus",-0.248416767621409,0.190927799384993,0.193223138196139,51,"C14orf166; C2orf49; CLP1; CPSF1; CPSF4; DDX1; ELAC2; FAM98B; NDC1; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188; NUP205; NUP210; NUP214; NUP35; NUP43; NUP50; NUP54; NUP58; NUP62; NUP85; NUP88; NUP93; NUP98; NUPL2; POM121; POP1; POP4; POP5; RAE1; RAN; RANBP2; RPP14; RPP21; RPP25; RPP30; RPP38; RPP40; RTCB; SEH1L; TRNT1; TSEN15; TSEN2; TSEN34; TSEN54; XPOT; ZBTB8OS"
"R-HSA-917937","Iron uptake and transport",0.243677580207865,0.187529283178535,0.19380297934871,52,"ABCG2; ACO1; ALAD; ATP6V0A1; ATP6V0A2; ATP6V0A4; ATP6V0B; ATP6V0C; ATP6V0D1; ATP6V0D2; ATP6V0E1; ATP6V0E2; ATP6V1A; ATP6V1B1; ATP6V1B2; ATP6V1C1; ATP6V1C2; ATP6V1D; ATP6V1E1; ATP6V1E2; ATP6V1F; ATP6V1G1; ATP6V1G2; ATP6V1H; CAND1; CP; CUL1; CYBRD1; FBXL5; FLVCR1; FTH1; FTL; GLRX3; HFE; HMOX1; HMOX2; IREB2; LCN2; NEDD8; SKP1; SLC11A2; SLC22A17; SLC40A1; SLC46A1; STEAP2; STEAP3; TCIRG1; TF; TFR2; TFRC; UBA52; UBC"
"R-HSA-139853","Elevation of cytosolic Ca2+ levels",-0.445556494155115,0.342922835049301,0.193844140977039,14,"ITPR1; ITPR2; ITPR3; ORAI2; P2RX1; P2RX2; P2RX3; P2RX4; P2RX5; P2RX6; P2RX7; STIM1; TRPC3; TRPC6"
"R-HSA-844456","The NLRP3 inflammasome",-0.491942867566111,0.378940018170568,0.194215956450992,11,"APP; CASP1; HSP90AB1; MEFV; NLRP3; P2RX7; PANX1; PSTPIP1; PYCARD; SUGT1; TXN"
"R-HSA-380320","Recruitment of NuMA to mitotic centrosomes",0.225358212205396,0.173890591684294,0.194983399357315,61,"ACTR1A; AKAP9; ALMS1; CCP110; CDK1; CDK5RAP2; CENPJ; CEP131; CEP135; CEP152; CEP164; CEP192; CEP250; CEP290; CEP41; CEP57; CEP63; CEP70; CEP72; CEP76; CEP78; CKAP5; CLASP1; CNTRL; CSNK1D; CSNK1E; DCTN1; DCTN2; DYNC1H1; DYNC1I2; DYNLL1; FGFR1OP; HAUS1; HAUS2; HAUS4; HAUS5; HAUS6; HAUS8; HSP90AA1; MAPRE1; MZT1; MZT2A; MZT2B; NDE1; NEDD1; NEK2; NINL; NUMA1; ODF2; PAFAH1B1; PCM1; PCNT; PLK1; PLK4; PPP2R1A; PRKAR2B; SDCCAG8; SFI1; SSNA1; TUBA1A; TUBA4A"
"R-HSA-5684996","MAPK1/MAPK3 signaling",0.236556222531351,0.182637543089877,0.195243546779703,55,"ACTN2; AKAP9; ANGPT1; APBB1IP; ARRB1; ARRB2; ARTN; BRAF; BRAP; BTC; CALM1; CAMK2A; CAMK2B; CAMK2D; CAMK2G; CDK1; CNKSR1; CSF2RB; CSK; CUL3; DAB2IP; DLG4; DUSP1; DUSP10; DUSP16; DUSP2; DUSP4; DUSP5; DUSP7; DUSP8; EGF; EGFR; ERBB2; ERBB3; ERBB4; EREG; FGA; FGB; FGF1; FGF10; FGF17; FGF18; FGF2; FGF20; FGF22; FGF5; FGF7; FGF9; FGFR1; FGFR2; FGFR3; FGFR4; FGG; FN1; FRS2"
"R-HSA-8851708","Signaling by FGFR2 IIIa TM",0.394189286391461,0.305317142877715,0.196675450591826,18,"FGF1; FGF2; FGFR2; GTF2F1; GTF2F2; NCBP1; NCBP2; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L"
"R-HSA-69481","G2/M Checkpoints",0.244246032280983,0.189318839963935,0.197005310251499,51,"ATM; ATR; ATRIP; BABAM1; BARD1; BLM; BRCA1; BRIP1; CCNB1; CCNB2; CDC25A; CDC45; CDC6; CDC7; CDK1; CDK2; CHEK1; CHEK2; DBF4; DNA2; EXO1; FAM175A; GTSE1; H2AFX; H2BFS; HERC2; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HUS1; KAT5; MCM10; MCM2; MCM3; MCM4; MCM5; MCM6; MCM7; MCM8; MDC1; MRE11; NBN; ORC1; ORC3; ORC4; ORC5; ORC6; PIAS4; PKMYT1; PSMA1"
"R-HSA-389513","CTLA4 inhibitory signaling",0.375619888485013,0.291431585153975,0.197440348565407,20,"AKT1; AKT2; AKT3; CD80; CD86; CTLA4; FYN; LYN; PDPK1; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5A; PPP2R5B; PPP2R5C; PPP2R5D; PPP2R5E; SRC; YES1"
"R-HSA-375280","Amine ligand-binding receptors",0.312009053886764,0.242546213732013,0.19830694347411,30,"ADRA1A; ADRA1B; ADRA1D; ADRA2A; ADRA2C; ADRB1; ADRB2; CHRM2; CHRM3; CHRM4; CHRM5; DRD1; DRD2; DRD4; DRD5; HRH1; HRH2; HRH3; HRH4; HTR1A; HTR1B; HTR1D; HTR1E; HTR1F; HTR2A; HTR2B; HTR4; HTR5A; HTR6; HTR7"
"R-HSA-388841","Costimulation by the CD28 family",0.23436347281517,0.182713712804458,0.199603734508712,55,"AKT1; AKT2; AKT3; CD247; CD274; CD28; CD3D; CD3E; CD4; CD80; CD86; CDC42; CSK; CTLA4; FYN; GRAP2; GRB2; HLA-DPA1; HLA-DPB1; HLA-DQA1; HLA-DQA2; HLA-DQB1; HLA-DQB2; HLA-DRA; HLA-DRB1; HLA-DRB5; ICOSLG; LYN; MAP3K8; MAPKAP1; MLST8; MTOR; PAK1; PAK2; PDCD1; PDCD1LG2; PDPK1; PIK3CA; PIK3R1; PIK3R2; PIK3R3; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5A; PPP2R5B; PPP2R5C; PPP2R5D; PPP2R5E; PRR5; PTPN6; RAC1; RICTOR; SRC"
"R-HSA-164378","PKA activation in glucagon signalling",-0.440350909185111,0.343627437509121,0.200025916642849,14,"ADCY1; ADCY2; ADCY3; ADCY4; ADCY5; ADCY6; ADCY7; ADCY9; GNAS; PRKACB; PRKAR1A; PRKAR1B; PRKAR2A; PRKAR2B"
"R-HSA-2682334","EPH-Ephrin signaling",0.21570616506546,0.170107225297885,0.204776530999919,64,"ACTG1; ACTR2; ACTR3; ADAM10; AP2A1; AP2A2; AP2B1; AP2M1; AP2S1; APH1A; APH1B; ARHGEF28; ARHGEF7; ARPC1A; ARPC1B; ARPC2; ARPC3; ARPC4; ARPC5; CDC42; CFL1; CLTA; CLTB; CLTC; CLTCL1; DNM1; EFNA1; EFNA2; EFNA5; EFNB2; EFNB3; EPHA1; EPHA10; EPHA2; EPHA3; EPHA4; EPHA5; EPHA6; EPHA7; EPHA8; EPHB1; EPHB2; EPHB3; EPHB4; EPHB6; FYN; GIT1; GRIN1; GRIN2B; HRAS; ITSN1; KALRN; LIMK1; LIMK2; LYN; MMP2; MMP9; MYH10; MYH11; MYH14; MYH9; MYL12A; MYL12B; MYL6"
"R-HSA-73893","DNA Damage Bypass",-0.271026482018365,0.214427048213374,0.206245606083878,40,"CUL4A; DDB1; DTL; ISG15; MAD2L2; NPLOC4; PCLAF; PCNA; POLD1; POLD2; POLD3; POLE; POLE2; POLE3; POLE4; POLI; POLK; RAD18; RCHY1; REV1; REV3L; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3; SPRTN; TRIM25; UBA52; UBA7; UBC; UBE2L6; USP1; USP10; VCP; WDR48; ZBTB32"
"R-HSA-202670","ERKs are inactivated",0.475446593636851,0.378944402871163,0.209602011871194,11,"DUSP3; DUSP4; DUSP7; MAPK1; MAPK3; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5D; VRK3"
"R-HSA-112043","PLC beta mediated events",-0.275219696362215,0.219762765474463,0.210442693446929,38,"ADCY1; ADCY2; ADCY3; ADCY4; ADCY5; ADCY6; ADCY7; ADCY9; AHCYL1; CALM1; CAMK4; GNAI1; GNAI2; GNAI3; GNAO1; GNAT1; GNAT2; GNAT3; GNAZ; ITPR1; ITPR2; ITPR3; MAPK1; PDE1A; PDE1B; PDE1C; PLA2G4A; PLCB1; PLCB2; PLCB3; PLCB4; PRKACB; PRKAR1A; PRKAR1B; PRKAR2A; PRKAR2B; PRKCA; PRKCD"
"R-HSA-6791226","Major pathway of rRNA processing in the nucleolus and cytosol",0.222949943272942,0.178356127597735,0.211289749659423,58,"BMS1; BYSL; C1D; CSNK1D; CSNK1E; DCAF13; DDX21; DDX49; DHX37; DIEXF; DIS3; EBNA1BP2; EMG1; ERI1; EXOSC1; EXOSC10; EXOSC2; EXOSC3; EXOSC4; EXOSC5; EXOSC6; EXOSC7; EXOSC8; EXOSC9; FAU; FBL; FCF1; FTSJ3; GNL3; HEATR1; IMP3; IMP4; KRR1; LTV1; MPHOSPH10; MPHOSPH6; NCL; NIP7; NOB1; NOC4L; NOL11; NOL6; NOL9; NOP14; NOP56; NOP58; PDCD11; PELP1; PES1; PNO1; PWP2; RBM28; RCL1; RIOK1; RIOK2; RIOK3; RPL10A; RPL12"
"R-HSA-5368287","Mitochondrial translation",0.222917865922177,0.178357161398775,0.2113581006097,58,"AURKAIP1; CHCHD1; DAP3; ERAL1; GFM1; GFM2; MRPL1; MRPL10; MRPL11; MRPL12; MRPL13; MRPL14; MRPL16; MRPL17; MRPL18; MRPL19; MRPL2; MRPL20; MRPL21; MRPL22; MRPL23; MRPL24; MRPL27; MRPL28; MRPL32; MRPL33; MRPL34; MRPL35; MRPL36; MRPL37; MRPL38; MRPL39; MRPL4; MRPL40; MRPL41; MRPL42; MRPL43; MRPL44; MRPL46; MRPL47; MRPL48; MRPL50; MRPL51; MRPL52; MRPL54; MRPL55; MRPL58; MRPL9; MRPS10; MRPS12; MRPS14; MRPS15; MRPS16; MRPS17; MRPS18A; MRPS18B; MRPS18C; MRPS2"
"R-HSA-8939236","RUNX1 regulates transcription of genes involved in differentiation of HSCs",0.254035039677686,0.20327678139253,0.211409074690027,44,"ABL1; CBFB; CCNH; CDK7; GATA3; H2AFJ; H2AFV; H2AFX; H2AFZ; H2BFS; H3F3A; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HIST2H2AA3; HIST2H2AC; ITCH; KMT2A; LDB1; LMO1; LMO2; MNAT1; MYB; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6"
"R-HSA-9020591","Interleukin-12 signaling",0.268712266586917,0.215130271939195,0.211640325844291,39,"AIP; ANXA2; BOLA2; CA1; CAPZA1; CDC42; CFL1; CNN2; FOXO3; GSTA2; GSTO1; HNRNPDL; HNRNPF; IL10; IL12A; IL12RB1; IL12RB2; JAK1; JAK2; LMNB1; MIF; MTAP; P4HB; PAK2; PDCD4; PITPNA; PPIA; PSME2; RALA; RAP1B; RPLP0; SERPINB2; SNRPA1; SOD1; SOD2; STAT4; TALDO1; TCP1; TYK2"
"R-HSA-416476","G alpha (q) signalling events",-0.23040333159338,0.184469528153401,0.211663307374319,55,"ABHD12; ABHD6; ADRA1A; ADRA1B; ADRA1D; AGT; AGTR1; ANXA1; APP; ARHGEF25; AVPR1A; BDKRB1; BDKRB2; CASR; CCK; CCKAR; CCKBR; CHRM3; CHRM5; CYSLTR2; DAGLA; DAGLB; DGKA; DGKB; DGKD; DGKE; DGKG; DGKH; DGKI; DGKQ; EDN1; EDN2; EDN3; EDNRA; EDNRB; EGFR; F2; F2R; F2RL1; F2RL2; F2RL3; FFAR1; FFAR3; FFAR4; FPR2; GCG; GHRL; GNA11; GNA14; GNA15; GNAQ; GNB1; GNB2; GNB3; GNB4"
"R-HSA-2555396","Mitotic Metaphase and Anaphase",-0.229878270942238,0.184484918636743,0.212744371773747,55,"AHCTF1; ANAPC1; ANAPC10; ANAPC11; ANAPC15; ANAPC16; ANAPC2; ANAPC4; ANAPC5; ANAPC7; ANKLE2; AURKB; B9D2; BANF1; BIRC5; BUB1B; BUB3; CDC16; CDC26; CDC27; CDCA5; CENPA; CENPC; CENPE; CENPF; CENPH; CENPK; CENPL; CENPM; CENPN; CENPO; CENPP; CENPQ; CENPT; CENPU; CKAP5; CLASP1; CLIP1; DSN1; DYNC1H1; DYNC1I1; DYNC1I2; DYNC1LI1; DYNC1LI2; DYNLL1; DYNLL2; ESPL1; FBXO5; INCENP; ITGB3BP; KIF2A; KIF2C; KNTC1; LEMD2; LEMD3"
"R-HSA-194068","Bile acid and bile salt metabolism",-0.280859831188455,0.225470353695745,0.212888543457006,36,"ABCC3; ACOT8; ACOX2; AKR1C1; AKR1C2; AKR1C3; ALB; AMACR; BAAT; CH25H; CYP27A1; CYP39A1; CYP46A1; CYP7A1; CYP7B1; CYP8B1; FABP6; HSD17B4; HSD3B7; NCOA1; NCOA2; NR1H4; OSBPL1A; OSBPL2; OSBPL3; OSBPL6; OSBPL7; OSBPL9; PTGIS; RXRA; SCP2; SLC10A1; SLC27A2; SLC27A5; SLCO1B3; STARD5"
"R-HSA-72187","mRNA 3'-end processing",0.253076590404162,0.203316907013956,0.213227511902311,44,"ALYREF; CASC3; CDC40; CHTOP; CLP1; CPSF1; CPSF2; CPSF3; CPSF4; CPSF7; CSTF1; CSTF2T; CSTF3; DDX39A; DDX39B; DHX38; EIF4A3; FIP1L1; FYTTD1; MAGOH; MAGOHB; NCBP1; NCBP2; NUDT21; PAPOLA; POLDIP3; RNPS1; SARNP; SLU7; SRRM1; SRSF11; SRSF4; SRSF5; SRSF6; SRSF7; SRSF9; THOC1; THOC3; THOC5; THOC7; U2AF1; U2AF1L4; U2AF2; ZC3H11A"
"R-HSA-193639","p75NTR signals via NF-kB",-0.456919360855602,0.368499894178009,0.214995979288204,12,"IKBKB; MYD88; NFKB1; NFKBIA; NGF; NGFR; PRKCI; RELA; RIPK2; TRAF6; UBA52; UBC"
"R-HSA-5654693","FRS-mediated FGFR1 signaling",0.389988901184192,0.314538629082333,0.215021257519915,17,"FGF1; FGF10; FGF17; FGF2; FGF20; FGF22; FGF5; FGF9; FGFR1; FRS2; FRS3; GRB2; HRAS; KL; KRAS; NRAS; SOS1"
"R-HSA-199220","Vitamin B5 (pantothenate) metabolism",0.41179601898269,0.332357142052841,0.215339347420464,15,"AASDHPPT; COASY; ENPP1; ENPP3; FASN; PANK1; PANK2; PANK3; PANK4; PPCDC; PPCS; SLC25A16; SLC5A6; VNN1; VNN2"
"R-HSA-111996","Ca-dependent events",-0.350518177357248,0.282973603639504,0.215458223106258,22,"ADCY1; ADCY2; ADCY3; ADCY4; ADCY5; ADCY6; ADCY7; ADCY9; CALM1; CAMK4; MAPK1; PDE1A; PDE1B; PDE1C; PLA2G4A; PRKACB; PRKAR1A; PRKAR1B; PRKAR2A; PRKAR2B; PRKCA; PRKCD"
"R-HSA-210993","Tie2 Signaling",0.389458078059694,0.314591725725201,0.215723696649529,17,"ANGPT1; ANGPT2; ANGPT4; DOK2; GRB14; GRB2; GRB7; HRAS; KRAS; NRAS; PIK3CA; PIK3CB; PIK3R1; PIK3R2; SHC1; SOS1; TEK"
"R-HSA-5654738","Signaling by FGFR2",0.221806662530644,0.179933098120447,0.21768121434416,57,"BRAF; CBL; ESRP1; ESRP2; FGF1; FGF10; FGF17; FGF18; FGF2; FGF20; FGF22; FGF5; FGF7; FGF9; FGFBP1; FGFBP2; FGFBP3; FGFR2; FRS2; FRS3; GAB1; GRB2; GTF2F1; GTF2F2; HNRNPA1; HNRNPF; HNRNPH1; HNRNPM; HRAS; KRAS; MAPK1; MAPK3; MKNK1; NCBP1; NCBP2; NRAS; PIK3CA; PIK3R1; PLCG1; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; PPP2CA; PPP2CB; PPP2R1A; PTBP1; RBFOX2; SHC1; SOS1"
"R-HSA-167242","Abortive elongation of HIV-1 transcript in the absence of Tat",0.345397599619467,0.28041489322462,0.218047076802476,22,"CTDP1; GTF2F1; GTF2F2; NCBP1; NCBP2; NELFA; NELFB; NELFCD; NELFE; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; SUPT4H1; SUPT5H"
"R-HSA-5387390","Hh mutants abrogate ligand secretion",0.240097613227599,0.195246390141405,0.218803466758643,48,"DERL2; DHH; ERLEC1; IHH; OS9; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; SEL1L; SEM1; SHH; SYVN1; UBA52; UBC; VCP"
"R-HSA-6788656","Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism",0.252375561501542,0.20567611677052,0.219802551844889,43,"AADAT; AASS; ACMSD; AFMID; ALDH4A1; ALDH7A1; AMDHD1; ASRGL1; CARNMT1; CARNS1; CRYM; DLD; DLST; FAH; FTCD; GCDH; GSTZ1; HAAO; HAL; HDC; HGD; HNMT; HPD; HYKK; IDO1; IDO2; IL4I1; KYAT1; KYAT3; KYNU; OGDH; PAH; PCBD1; PHYKPL; PIPOX; PRODH; QDPR; SLC25A21; SLC36A4; SLC7A5; TAT; TDO2; UROC1"
"R-HSA-6781823","Formation of TC-NER Pre-Incision Complex",0.248826331358017,0.203493334128766,0.22141511795825,44,"AQR; CCNH; CDK7; COPS2; COPS3; COPS6; COPS7A; COPS7B; COPS8; CUL4A; DDB1; EP300; ERCC3; ERCC6; ERCC8; GPS1; GTF2H1; GTF2H2; GTF2H3; GTF2H4; GTF2H5; HMGN1; ISY1; MNAT1; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; PPIE; PRPF19; TCEA1; UBA52; UBC; USP7; UVSSA; XAB2; XPA"
"R-HSA-397014","Muscle contraction",-0.221694146858583,0.181486281869774,0.22187872376793,57,"ABCC9; ACTA2; ACTN2; AHCYL1; AKAP9; ANXA1; ANXA2; ANXA6; ASPH; ATP1A1; ATP1A2; ATP1A3; ATP1A4; ATP1B1; ATP1B2; ATP1B3; ATP2A1; ATP2A2; ATP2A3; ATP2B1; ATP2B2; ATP2B4; CACNA1C; CACNA1D; CACNA1S; CACNA2D1; CACNA2D2; CACNA2D3; CACNA2D4; CACNB1; CACNB2; CACNB3; CACNB4; CACNG1; CACNG3; CACNG4; CACNG5; CACNG6; CACNG8; CALD1; CALM1; CAMK2A; CAMK2B; CAMK2D; CAMK2G; CAV3; CORIN; DYSF; FGF11; FGF12; FGF14; FKBP1B; FXYD1; FXYD2; FXYD3; FXYD4; FXYD6"
"R-HSA-2691230","Signaling by NOTCH1 HD Domain Mutants in Cancer",-0.450296511729249,0.369501447567608,0.222973391595725,12,"ADAM10; ADAM17; DLL1; JAG1; JAG2; MIB1; MIB2; NEURL1; NEURL1B; NOTCH1; UBA52; UBC"
"R-HSA-2691232","Constitutive Signaling by NOTCH1 HD Domain Mutants",-0.450296511729249,0.369501447567608,0.222973391595725,12,"ADAM10; ADAM17; DLL1; JAG1; JAG2; MIB1; MIB2; NEURL1; NEURL1B; NOTCH1; UBA52; UBC"
"R-HSA-1187000","Fertilization",0.374382803915606,0.30721704068577,0.22298601484164,18,"ACR; ADAM20; ADAM21; B4GALT1; CATSPER1; CATSPER2; CATSPER3; CATSPER4; CATSPERB; CATSPERD; CATSPERG; CD9; IZUMO1; IZUMO4; OVGP1; ZP1; ZP2; ZP3"
"R-HSA-5694530","Cargo concentration in the ER",-0.304105324677549,0.24970737309467,0.223282196848699,29,"AREG; CD59; CNIH1; CNIH2; CNIH3; CTAGE5; CTSC; CTSZ; F5; FOLR1; GOSR2; GRIA1; LMAN1; LMAN1L; LMAN2; LMAN2L; MCFD2; MIA3; PREB; SAR1B; SEC24A; SEC24B; SEC24C; SEC24D; SERPINA1; STX5; TGFA; TMED10; TMED2"
"R-HSA-2024101","CS/DS degradation",-0.466606733231478,0.383211819327431,0.223368055635899,11,"ARSB; BCAN; CSPG4; CSPG5; DCN; HEXA; HEXB; HYAL1; HYAL3; IDUA; VCAN"
"R-HSA-5633007","Regulation of TP53 Activity",0.207123251674487,0.170357583837147,0.224055524459499,64,"AKT1; AKT2; AKT3; ATM; ATR; ATRIP; AURKA; AURKB; BANP; BARD1; BLM; BRCA1; BRD7; BRIP1; BRPF3; CCNA1; CCNA2; CCNG1; CDK1; CDK2; CDK5R1; CDKN2A; CHD3; CHD4; CHEK1; CHEK2; CSNK2A2; CSNK2B; DAXX; DNA2; DYRK2; EHMT1; EHMT2; EP300; EXO1; GATAD2A; GATAD2B; HDAC1; HDAC2; HIPK1; HIPK2; HUS1; ING2; ING5; JMY; KAT5; KAT6A; KMT5A; L3MBTL1; MAP2K6; MAPK11; MAPK14; MAPKAP1; MAPKAPK5; MBD3; MDM2; MDM4; MEAF6; MLST8; MRE11; MTA2; MTOR; NBN; NOC2L"
"R-HSA-166016","Toll Like Receptor 4 (TLR4) Cascade",0.218810157470054,0.180029691060097,0.224209182784786,57,"AGER; APP; ATF1; ATF2; BIRC2; BIRC3; BPI; BTRC; CASP8; CD14; CD180; CD36; CHUK; CUL1; DNM1; DNM2; DNM3; DUSP3; DUSP4; DUSP7; ECSIT; FADD; FBXW11; FOS; IKBKB; IRAK2; IRAK3; IRAK4; IRF3; IRF7; ITGAM; ITGB2; LBP; LY86; LY96; MAP2K1; MAP2K3; MAP2K4; MAP2K6; MAP2K7; MAP3K1; MAP3K7; MAP3K8; MAPK1; MAPK10; MAPK11; MAPK14; MAPK3; MAPK8; MAPK9; MAPKAPK2; MAPKAPK3; MEF2A; MEF2C; MYD88; NFKB1; NFKB2"
"R-HSA-948021","Transport to the Golgi and subsequent modification",-0.206856678500887,0.170445476304685,0.22489143265607,65,"ACTR10; ACTR1A; ANK1; ANK2; ANK3; ANKRD28; ARCN1; AREG; ARF3; ARF4; ARF5; ARFGAP1; ARFGAP2; ARFGAP3; B4GALT1; B4GALT2; B4GALT3; B4GALT4; B4GALT5; B4GALT6; BET1; BET1L; CAPZA1; CAPZA2; CAPZA3; CAPZB; CD55; CD59; CGA; CHST10; CHST8; CNIH1; CNIH2; CNIH3; COG1; COG2; COG3; COG4; COG5; COG6; COG7; COG8; COPA; COPB1; COPB2; COPE; COPG1; COPG2; COPZ1; COPZ2; CSNK1D; CTAGE5; CTSC; CTSZ; DCTN1; DCTN2; DCTN4; DCTN5; DCTN6; DYNC1H1; DYNC1I1; DYNC1I2; DYNC1LI1; DYNC1LI2; DYNLL1"
"R-HSA-392170","ADP signalling through P2Y purinoceptor 12",0.364015395544287,0.300004347514355,0.224989511286649,19,"GNAI1; GNAI2; GNAI3; GNAT3; GNB1; GNB2; GNB3; GNB4; GNB5; GNG10; GNG11; GNG12; GNG2; GNG3; GNG4; GNG5; GNG7; GNGT2; P2RY12"
"R-HSA-5674400","Constitutive Signaling by AKT1 E17K in Cancer",0.355524209903816,0.293180940845378,0.225265826881158,20,"AKT1; AKT1S1; AKT2; AKT3; BAD; CASP9; CDKN1B; CHUK; FOXO1; FOXO3; GSK3B; MAPKAP1; MDM2; MLST8; MTOR; PDPK1; PRR5; RICTOR; RPS6KB2; TSC2"
"R-HSA-5673001","RAF/MAP kinase cascade",0.222025626524876,0.183131419943391,0.225365374448041,55,"ACTN2; AKAP9; ANGPT1; APBB1IP; ARRB1; ARRB2; ARTN; BRAF; BRAP; BTC; CALM1; CAMK2A; CAMK2B; CAMK2D; CAMK2G; CNKSR1; CSF2RB; CSK; CUL3; DAB2IP; DLG4; DUSP1; DUSP10; DUSP16; DUSP2; DUSP4; DUSP5; DUSP7; DUSP8; EGF; EGFR; ERBB2; ERBB3; ERBB4; EREG; FGA; FGB; FGF1; FGF10; FGF17; FGF18; FGF2; FGF20; FGF22; FGF5; FGF7; FGF9; FGFR1; FGFR2; FGFR3; FGFR4; FGG; FN1; FRS2; FRS3"
"R-HSA-112040","G-protein mediated events",-0.263484969316301,0.217456768877261,0.225640266110345,39,"ADCY1; ADCY2; ADCY3; ADCY4; ADCY5; ADCY6; ADCY7; ADCY9; AHCYL1; CALM1; CAMK4; GNAI1; GNAI2; GNAI3; GNAL; GNAO1; GNAT1; GNAT2; GNAT3; GNAZ; ITPR1; ITPR2; ITPR3; MAPK1; PDE1A; PDE1B; PDE1C; PLA2G4A; PLCB1; PLCB2; PLCB3; PLCB4; PRKACB; PRKAR1A; PRKAR1B; PRKAR2A; PRKAR2B; PRKCA; PRKCD"
"R-HSA-5419276","Mitochondrial translation termination",0.215943831235277,0.17857903057954,0.226572967968644,58,"AURKAIP1; CHCHD1; DAP3; ERAL1; GFM2; MRPL1; MRPL10; MRPL11; MRPL12; MRPL13; MRPL14; MRPL16; MRPL17; MRPL18; MRPL19; MRPL2; MRPL20; MRPL21; MRPL22; MRPL23; MRPL24; MRPL27; MRPL28; MRPL32; MRPL33; MRPL34; MRPL35; MRPL36; MRPL37; MRPL38; MRPL39; MRPL4; MRPL40; MRPL41; MRPL42; MRPL43; MRPL44; MRPL46; MRPL47; MRPL48; MRPL50; MRPL51; MRPL52; MRPL54; MRPL55; MRPL58; MRPL9; MRPS10; MRPS12; MRPS14; MRPS15; MRPS16; MRPS17; MRPS18A; MRPS18B; MRPS18C; MRPS2; MRPS22"
"R-HSA-193648","NRAGE signals death through JNK",-0.229369677304435,0.189687495277446,0.226586912689061,52,"ABR; AKAP13; ARHGEF10; ARHGEF10L; ARHGEF11; ARHGEF12; ARHGEF15; ARHGEF16; ARHGEF17; ARHGEF18; ARHGEF19; ARHGEF2; ARHGEF26; ARHGEF3; ARHGEF33; ARHGEF35; ARHGEF37; ARHGEF38; ARHGEF39; ARHGEF4; ARHGEF40; ARHGEF5; ARHGEF7; BAD; BCL2L11; ECT2; FGD2; FGD3; FGD4; GNA13; ITSN1; KALRN; MAPK8; MCF2L; NET1; NGEF; NGF; NGFR; OBSCN; PLEKHG2; PLEKHG5; PREX1; RAC1; RASGRF2; SOS1; SOS2; TIAM1; TIAM2; TRIO; VAV1; VAV2; VAV3"
"R-HSA-2024096","HS-GAG degradation",0.371619017755948,0.307475780907575,0.226811819946803,18,"AGRN; GLB1; GLB1L; GPC1; GPC2; GPC5; GPC6; GUSB; HPSE; HPSE2; HSPG2; IDUA; NAGLU; SDC1; SDC2; SDC3; SDC4; SGSH"
"R-HSA-5173214","O-glycosylation of TSR domain-containing proteins",-0.280156786987708,0.231988375352428,0.227188510853626,34,"ADAMTS10; ADAMTS12; ADAMTS13; ADAMTS14; ADAMTS15; ADAMTS16; ADAMTS17; ADAMTS18; ADAMTS19; ADAMTS2; ADAMTS3; ADAMTS4; ADAMTS5; ADAMTS6; ADAMTS7; ADAMTS8; ADAMTS9; ADAMTSL1; ADAMTSL2; ADAMTSL3; ADAMTSL4; ADAMTSL5; B3GLCT; POFUT2; SBSPON; SEMA5A; SEMA5B; SPON2; THBS1; THBS2; THSD1; THSD4; THSD7A; THSD7B"
"R-HSA-187037","NGF signalling via TRKA from the plasma membrane",0.208754881100996,0.173003369090526,0.227566147743996,62,"ADCYAP1; ADCYAP1R1; ADORA2A; AP2A1; AP2A2; AP2B1; AP2M1; AP2S1; ATF1; BRAF; CLTA; CLTC; CRK; CRKL; DNAL4; DNM1; DNM2; DNM3; DUSP3; DUSP4; DUSP7; FRS2; GRB2; HRAS; IRS1; IRS2; KIDINS220; KRAS; MAP2K5; MAPK1; MAPK11; MAPK12; MAPK13; MAPK14; MAPK3; MAPKAPK2; MAPKAPK3; MEF2A; MEF2C; NGF; NRAS; NTRK1; NTRK2; PIK3CA; PIK3CB; PIK3R1; PIK3R2; PLCG1; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5D; RALA; RALB; RALGDS; RAP1A; RAPGEF1; RIT1; RIT2; RPS6KA1; RPS6KA2"
"R-HSA-198725","Nuclear Events (kinase and transcription factor activation)",0.351949612106688,0.293483809887696,0.230445117740635,20,"ATF1; DUSP3; DUSP4; DUSP7; MAPK1; MAPK11; MAPK14; MAPK3; MAPKAPK2; MEF2A; MEF2C; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5D; RPS6KA1; RPS6KA2; RPS6KA5; VRK3"
"R-HSA-69231","Cyclin D associated events in G1",0.264529521597802,0.221021743250745,0.23136564618124,37,"ABL1; CCND1; CCND2; CCND3; CCNH; CDK4; CDK6; CDK7; CDKN1B; CDKN1C; CDKN2A; CDKN2B; CDKN2C; CDKN2D; CUL1; E2F1; E2F2; E2F4; E2F5; JAK2; LYN; MNAT1; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R2A; PTK6; RB1; RBL1; RBL2; SKP1; SKP2; SRC; TFDP1; UBA52; UBC"
"R-HSA-69236","G1 Phase",0.264529521597802,0.221021743250745,0.23136564618124,37,"ABL1; CCND1; CCND2; CCND3; CCNH; CDK4; CDK6; CDK7; CDKN1B; CDKN1C; CDKN2A; CDKN2B; CDKN2C; CDKN2D; CUL1; E2F1; E2F2; E2F4; E2F5; JAK2; LYN; MNAT1; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R2A; PTK6; RB1; RBL1; RBL2; SKP1; SKP2; SRC; TFDP1; UBA52; UBC"
"R-HSA-114508","Effects of PIP2 hydrolysis",-0.332659738240704,0.278164218244102,0.231731166025426,23,"ABHD12; ABHD6; DAGLA; DAGLB; DGKA; DGKB; DGKD; DGKE; DGKG; DGKH; DGKI; DGKQ; ITPR1; ITPR2; ITPR3; MGLL; PRKCD; PRKCE; PRKCH; PRKCQ; RASGRP1; TRPC3; TRPC6"
"R-HSA-611105","Respiratory electron transport",-0.224805615643748,0.188044011474955,0.231893812891175,53,"ACAD9; COQ10A; COQ10B; COX11; COX14; COX16; COX18; COX19; COX20; COX4I1; COX5A; COX5B; COX6A1; COX6B1; COX6C; COX7A2L; COX8A; CYC1; CYCS; ECSIT; ETFA; ETFB; ETFDH; LRPPRC; NDUFA10; NDUFA11; NDUFA12; NDUFA13; NDUFA2; NDUFA3; NDUFA4; NDUFA5; NDUFA6; NDUFA7; NDUFA8; NDUFA9; NDUFAB1; NDUFAF1; NDUFAF2; NDUFAF3; NDUFAF4; NDUFAF5; NDUFAF6; NDUFAF7; NDUFB1; NDUFB10; NDUFB2; NDUFB3; NDUFB4; NDUFB5; NDUFB6; NDUFB8; NDUFB9"
"R-HSA-167238","Pausing and recovery of Tat-mediated HIV elongation",0.300886417365991,0.25169505808002,0.231915045671976,28,"CCNT1; CDK9; CTDP1; ELL; ELOA; ELOC; GTF2F1; GTF2F2; NELFA; NELFB; NELFCD; NELFE; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; SSRP1; SUPT16H; SUPT4H1; SUPT5H; TCEA1"
"R-HSA-167243","Tat-mediated HIV elongation arrest and recovery",0.300886417365991,0.25169505808002,0.231915045671976,28,"CCNT1; CDK9; CTDP1; ELL; ELOA; ELOC; GTF2F1; GTF2F2; NELFA; NELFB; NELFCD; NELFE; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; SSRP1; SUPT16H; SUPT4H1; SUPT5H; TCEA1"
"R-HSA-212676","Dopamine Neurotransmitter Release Cycle",-0.353636948414294,0.296439231370764,0.232889262943861,20,"APBA1; CPLX1; LIN7A; LIN7B; LIN7C; PPFIA1; PPFIA2; PPFIA3; PPFIA4; RAB3A; RIMS1; SLC18A2; SNAP25; STX1A; STXBP1; SYN3; SYT1; TSPOAP1; UNC13B; VAMP2"
"R-HSA-901032","ER Quality Control Compartment (ERQC)",-0.361700189388374,0.303370303205853,0.233154259287843,19,"AMFR; DERL2; EDEM1; EDEM2; EDEM3; MAN1B1; MARCH6; OS9; RNF103; RNF139; RNF185; RNF5; SEL1L; SYVN1; TRIM13; UBA52; UBC; UGGT1; UGGT2"
"R-HSA-201722","Formation of the beta-catenin:TCF transactivating complex",0.257007168357373,0.215670068130041,0.233391359955611,39,"AXIN2; BCL9; CDC73; CTNNB1; EP300; H2AFJ; H2AFV; H2AFX; H2AFZ; H2BFS; H3F3A; HDAC1; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HIST2H2AA3; HIST2H2AC; KAT5; LEF1; LEO1; MEN1; MYC; PYGO1; PYGO2; RBBP5; RUNX3; RUVBL1; SMARCA4; TCF4; TCF7; TCF7L1; TCF7L2; TERT; TLE1; TLE2; TLE3; TLE4; TRRAP"
"R-HSA-5607764","CLEC7A (Dectin-1) signaling",0.210972929342056,0.178733646308543,0.237850652200773,58,"AHCYL1; BCL10; BTRC; CALM1; CARD11; CARD9; CASP8; CCL17; CCL22; CDC34; CHUK; CLEC7A; CUL1; FBXW11; IKBKB; IL1B; ITPR1; ITPR2; ITPR3; MALT1; MAP3K7; NFATC1; NFATC3; NFKB1; NFKB2; NFKBIA; PDPK1; PLCG2; PPP3CA; PPP3CB; PPP3R1; PRKCD; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3"
"R-HSA-8940973","RUNX2 regulates osteoblast differentiation",0.331546245513343,0.281490279127167,0.238866440031123,22,"ABL1; BGLAP; CBFB; COL1A1; GLI3; HDAC3; HES1; HEY1; HEY2; MAF; MAPK1; MAPK3; RB1; RUNX2; SATB2; SP7; SRC; UCMA; WWTR1; YAP1; YES1; ZNF521"
"R-HSA-6788467","IL-6-type cytokine receptor ligand interactions",-0.396241749929814,0.337445485914502,0.240299190159466,15,"CLCF1; CNTF; CNTFR; CRLF1; CTF1; IL11RA; IL31RA; IL6ST; JAK1; JAK2; LIF; LIFR; OSM; OSMR; TYK2"
"R-HSA-140877","Formation of Fibrin Clot (Clotting Cascade)",0.273407214870869,0.23347753288335,0.241590128145423,33,"A2M; C1QBP; F10; F11; F12; F13A1; F2; F2R; F3; F5; F7; FGA; FGB; FGG; GP1BA; GP5; KLKB1; KNG1; PF4; PF4V1; PRCP; PROC; PROCR; PROS1; PRTN3; SERPINA5; SERPINC1; SERPIND1; SERPINE2; SERPING1; TFPI; THBD; VWF"
"R-HSA-5663213","RHO GTPases Activate WASPs and WAVEs",0.285589041946446,0.244110690583477,0.242034709647236,30,"ABI1; ABL1; ACTG1; ACTR2; ACTR3; ARPC1A; ARPC1B; ARPC2; ARPC3; ARPC4; ARPC5; BAIAP2; BRK1; CDC42; CYFIP2; GRB2; MAPK1; MAPK3; NCK1; NCKAP1; NCKAP1L; NCKIPSD; PTK2; RAC1; WASF1; WASF3; WASL; WIPF1; WIPF2; WIPF3"
"R-HSA-162710","Synthesis of glycosylphosphatidylinositol (GPI)",0.39110468060037,0.334622604243088,0.242486893072796,15,"DPM2; PIGB; PIGC; PIGF; PIGG; PIGH; PIGL; PIGM; PIGN; PIGO; PIGP; PIGQ; PIGV; PIGX; PIGZ"
"R-HSA-5693567","HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)",0.224170516820814,0.191916442372389,0.242781308611437,50,"ABL1; ATM; ATR; ATRIP; BABAM1; BARD1; BLM; BRCA1; BRCA2; BRIP1; CCNA1; CCNA2; CDK2; CHEK1; DNA2; EME1; EME2; ERCC4; EXO1; FAM175A; GEN1; H2AFX; H2BFS; HERC2; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HUS1; KAT5; MDC1; MRE11; MUS81; NBN; PALB2; PCNA; PIAS4; POLD1; POLD2; POLD3; POLE; POLE2; POLE3; POLE4; POLK; PPP4C; PPP4R2; RAD1; RAD17; RAD50"
"R-HSA-5693607","Processing of DNA double-strand break ends",0.219723433608312,0.188360294286113,0.24340988089187,52,"ATM; ATR; ATRIP; BABAM1; BARD1; BLM; BRCA1; BRIP1; CCNA1; CCNA2; CDK2; CHEK1; DNA2; EXO1; FAM175A; H2AFX; H2BFS; HERC2; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HUS1; KAT5; MDC1; MRE11; NBN; PIAS4; PPP4C; PPP4R2; RAD1; RAD17; RAD50; RAD9A; RAD9B; RBBP8; RFC2; RFC3; RFC4; RFC5; RHNO1; RMI1; RMI2; RNF168; RNF4; RNF8; RPA1; RPA2; RPA3; SIRT6; SUMO1; SUMO2"
"R-HSA-212165","Epigenetic regulation of gene expression",0.23529797650225,0.201778182326076,0.243565125026941,45,"AEBP2; ARID4B; BAZ1B; BAZ2A; CBX3; CCNH; CDK7; CHD3; CHD4; DDX21; DEK; DNMT1; DNMT3A; DNMT3B; EED; EHMT2; EP300; ERCC3; ERCC6; EZH2; GATAD2A; GATAD2B; GSK3B; GTF2H1; GTF2H2; GTF2H3; GTF2H4; GTF2H5; H2AFJ; H2AFV; H2AFX; H2AFZ; H2BFS; H3F3A; HDAC1; HDAC2; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HIST2H2AA3; HIST2H2AC; JARID2; KAT2A; KAT2B"
"R-HSA-372790","Signaling by GPCR",-0.212976678829149,0.183317441190546,0.245320092548459,56,"ABCA4; ABHD12; ABHD6; ABR; ACKR1; ACKR3; ACKR4; ADCY1; ADCY2; ADCY3; ADCY4; ADCY5; ADCY6; ADCY7; ADCY9; ADCYAP1; ADCYAP1R1; ADGRE1; ADGRE2; ADM; ADM2; ADORA1; ADORA2A; ADORA2B; ADRA1A; ADRA1B; ADRA1D; ADRA2A; ADRA2C; ADRB1; ADRB2; AGRN; AGT; AGTR1; AHCYL1; AKAP13; AKR1B10; AKR1C1; AKR1C3; AKT1; AKT2; AKT3; ANXA1; APLNR; APOA1; APOA2; APOB; APOC3; APOM; APP; ARHGEF10; ARHGEF10L; ARHGEF11; ARHGEF12; ARHGEF15; ARHGEF16"
"R-HSA-1834949","Cytosolic sensors of pathogen-associated DNA ",0.205921085450706,0.177382134931068,0.245686776320125,59,"AGER; APP; CHUK; CRCP; CTNNB1; DDX41; DHX36; DTX4; EP300; IFI16; IKBKB; IRF3; IRF7; LRRFIP1; MB21D1; MRE11; MYD88; NFKB1; NFKB2; NFKBIA; NFKBIB; NKIRAS1; NLRP4; POLR1C; POLR1D; POLR2E; POLR2F; POLR2H; POLR2K; POLR2L; POLR3A; POLR3B; POLR3C; POLR3D; POLR3F; POLR3G; POLR3GL; POLR3H; POLR3K; PRKDC; RELA; RIPK1; RIPK3; S100A12; S100B; SAA1; STAT6; TBK1; TICAM1; TLR3; TMEM173; TREX1; TRIM21; TRIM32; TRIM56; UBA52; UBC; XRCC5; XRCC6"
"R-HSA-8853659","RET signaling",0.256881039307749,0.221382368675238,0.245906320689892,37,"ARTN; DOK1; DOK2; DOK4; DOK5; DOK6; FRS2; GAB1; GAB2; GDNF; GFRA1; GFRA2; GFRA3; GFRA4; GRB10; GRB2; GRB7; IRS2; NRTN; PDLIM7; PIK3CA; PIK3CB; PIK3CD; PIK3R1; PIK3R2; PIK3R3; PLCG1; PRKACB; PRKCA; PSPN; RAP1GAP; RET; SHANK3; SHC1; SHC3; SOS1; SRC"
"R-HSA-2500257","Resolution of Sister Chromatid Cohesion",-0.214162900179596,0.184926388245875,0.24682400239638,55,"AHCTF1; AURKB; B9D2; BIRC5; BUB1B; BUB3; CCNB1; CCNB2; CDCA5; CDK1; CENPA; CENPC; CENPE; CENPF; CENPH; CENPK; CENPL; CENPM; CENPN; CENPO; CENPP; CENPQ; CENPT; CENPU; CKAP5; CLASP1; CLIP1; DSN1; DYNC1H1; DYNC1I1; DYNC1I2; DYNC1LI1; DYNC1LI2; DYNLL1; DYNLL2; INCENP; ITGB3BP; KIF2A; KIF2C; KNTC1; MAD1L1; MAD2L1; MAPRE1; MIS12; NDE1; NDEL1; NSL1; NUDC; NUF2; NUP107; NUP133; NUP160; NUP43; NUP85; NUP98"
"R-HSA-168927","TICAM1, RIP1-mediated IKK complex recruitment ",0.386516613897048,0.335112047405358,0.248748226723944,15,"BIRC2; BIRC3; CHUK; IKBKB; RIPK1; RIPK3; TICAM1; TLR3; TRAF6; UBA52; UBC; UBE2D1; UBE2D3; UBE2N; UBE2V1"
"R-HSA-1839126","FGFR2 mutant receptor activation",0.300986333327214,0.261126617829819,0.249056057357561,26,"FGF1; FGF10; FGF17; FGF18; FGF2; FGF20; FGF22; FGF5; FGF7; FGF9; FGFR2; GTF2F1; GTF2F2; NCBP1; NCBP2; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L"
"R-HSA-447115","Interleukin-12 family signaling",0.227330563950337,0.19777478927852,0.250373947829891,47,"AIP; ANXA2; BOLA2; CA1; CANX; CAPZA1; CDC42; CFL1; CNN2; CRLF1; FOXO3; GSTA2; GSTO1; HNRNPDL; HNRNPF; IL10; IL12A; IL12RB1; IL12RB2; IL23A; IL27; IL27RA; IL6ST; JAK1; JAK2; LMNB1; MIF; MTAP; P4HB; PAK2; PDCD4; PITPNA; PPIA; PSME2; RALA; RAP1B; RPLP0; SERPINB2; SNRPA1; SOD1; SOD2; STAT1; STAT3; STAT4; TALDO1; TCP1; TYK2"
"R-HSA-8866652","Synthesis of active ubiquitin: roles of E1 and E2 enzymes",0.323828793736233,0.282073544915985,0.250956322911848,22,"CDC34; OTULIN; UBA52; UBA6; UBC; UBE2D1; UBE2E1; UBE2E3; UBE2G1; UBE2G2; UBE2H; UBE2K; UBE2L3; UBE2Q2; UBE2R2; UBE2S; UBE2T; UBE2W; UBE2Z; UCHL3; USP5; USP7"
"R-HSA-8874081","MET activates PTK2 signaling",0.35470456870313,0.309024788741367,0.251043232289404,18,"HGF; ITGA2; ITGA3; ITGB1; LAMA1; LAMA2; LAMA3; LAMA4; LAMA5; LAMB1; LAMB2; LAMB3; LAMC1; LAMC2; LAMC3; MET; PTK2; SRC"
"R-HSA-1483191","Synthesis of PC",0.305233696983161,0.265984410934496,0.251149277910769,25,"ABHD3; ACHE; BCHE; CEPT1; CHKA; CHKB; CHPT1; CSNK2A2; CSNK2B; LPCAT1; LPIN1; LPIN2; LPIN3; MFSD2A; PCTP; PCYT1A; PEMT; PHOSPHO1; SLC44A1; SLC44A2; SLC44A3; SLC44A4; SLC44A5; STARD10; STARD7"
"R-HSA-2033519","Activated point mutants of FGFR2",0.439692758331454,0.38405973296444,0.252269170613679,11,"FGF1; FGF10; FGF17; FGF18; FGF2; FGF20; FGF22; FGF5; FGF7; FGF9; FGFR2"
"R-HSA-2559586","DNA Damage/Telomere Stress Induced Senescence",0.247042206019593,0.216113854799825,0.252992351487179,39,"ACD; ASF1A; ATM; CABIN1; CCNA1; CCNA2; CCNE1; CCNE2; CDK2; CDKN1B; EP400; H1F0; H2AFJ; H2AFV; H2AFX; H2AFZ; H2BFS; HIST1H1C; HIST1H1D; HIST1H1E; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HIST2H2AA3; HIST2H2AC; HMGA1; HMGA2; KAT5; LMNB1; MRE11; NBN; POT1; RAD50; RB1; TERF1; TERF2; TERF2IP; UBN1"
"R-HSA-198753","ERK/MAPK targets",0.352002653395829,0.309266692773036,0.255043318183396,18,"DUSP3; DUSP4; DUSP7; MAPK1; MAPK11; MAPK14; MAPK3; MEF2A; MEF2C; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5D; RPS6KA1; RPS6KA2; RPS6KA5; VRK3"
"R-HSA-168898","Toll-Like Receptors Cascades",0.203257446647082,0.178967786416974,0.256073411347065,58,"AGER; APOB; APP; ATF1; ATF2; BIRC2; BIRC3; BPI; BTRC; CASP8; CD14; CD180; CD36; CHUK; CNPY3; CTSB; CTSK; CTSL; CTSS; CTSV; CUL1; DHX36; DNM1; DNM2; DNM3; DUSP3; DUSP4; DUSP7; ECSIT; EEA1; FADD; FBXW11; FGA; FGB; FGG; FOS; HSP90B1; IKBKB; IRAK2; IRAK3; IRAK4; IRF3; IRF7; ITGAM; ITGB2; LBP; LGMN; LY86; LY96; MAP2K1; MAP2K3; MAP2K4; MAP2K6; MAP2K7; MAP3K1; MAP3K7; MAP3K8; MAPK1"
"R-HSA-5663202","Diseases of signal transduction",0.201249897281533,0.177520565498857,0.256932625176062,59,"ADAM10; ADAM17; AGGF1; AGK; AGTRAP; AKAP9; AKT1; AKT1S1; AKT2; AKT3; AP3B1; APBB1IP; APC; APH1A; APH1B; ARRB1; ARRB2; ATG7; AXIN1; BAD; BCL2L11; BCR; BRAF; BRAP; BTC; CASP9; CBL; CCNC; CD19; CD28; CD80; CD86; CDC37; CDK8; CDKN1B; CHUK; CLCN6; CNKSR1; CNTRL; CPSF6; CSK; CSNK1A1; CTBP1; CTBP2; CTNNB1; CUL1; CUX1; DAB2IP; DERL2; DHH; DKK1; DKK4; DLL1; EGF; EGFR; EP300; ERBB2; ERBB3; ERBB4"
"R-HSA-388396","GPCR downstream signalling",-0.206042624373362,0.181898035572364,0.257324739644995,57,"ABCA4; ABHD12; ABHD6; ABR; ACKR3; ADCY1; ADCY2; ADCY3; ADCY4; ADCY5; ADCY6; ADCY7; ADCY9; ADCYAP1; ADCYAP1R1; ADM; ADM2; ADORA1; ADORA2A; ADORA2B; ADRA1A; ADRA1B; ADRA1D; ADRA2A; ADRA2C; ADRB1; ADRB2; AGRN; AGT; AGTR1; AHCYL1; AKAP13; AKR1B10; AKR1C1; AKR1C3; AKT1; AKT2; AKT3; ANXA1; APLNR; APOA1; APOA2; APOB; APOC3; APOM; APP; ARHGEF10; ARHGEF10L; ARHGEF11; ARHGEF12; ARHGEF15; ARHGEF16; ARHGEF17; ARHGEF18; ARHGEF19; ARHGEF2; ARHGEF25"
"R-HSA-5576891","Cardiac conduction",-0.202686251244193,0.180423100889527,0.261270144590259,58,"ABCC9; AHCYL1; AKAP9; ASPH; ATP1A1; ATP1A2; ATP1A3; ATP1A4; ATP1B1; ATP1B2; ATP1B3; ATP2A1; ATP2A2; ATP2A3; ATP2B1; ATP2B2; ATP2B4; CACNA1C; CACNA1D; CACNA1S; CACNA2D1; CACNA2D2; CACNA2D3; CACNA2D4; CACNB1; CACNB2; CACNB3; CACNB4; CACNG1; CACNG3; CACNG4; CACNG5; CACNG6; CACNG8; CALM1; CAMK2A; CAMK2B; CAMK2D; CAMK2G; CORIN; FGF11; FGF12; FGF14; FKBP1B; FXYD1; FXYD2; FXYD3; FXYD4; FXYD6; FXYD7; HIPK1; HIPK2; ITPR1; ITPR2; ITPR3; KAT2B; KCND3; KCNE1"
"R-HSA-75105","Fatty acyl-CoA biosynthesis",0.255302942857708,0.227648189080297,0.262083503319107,35,"ACLY; ACSBG1; ACSBG2; ACSF3; ACSL1; ACSL3; ACSL5; ACSL6; CBR4; ELOVL1; ELOVL2; ELOVL3; ELOVL4; ELOVL5; ELOVL6; ELOVL7; FASN; HACD1; HACD2; HACD3; HACD4; HSD17B12; HSD17B3; HSD17B8; MORC2; OLAH; PPT1; PPT2; RPP14; SCD; SCD5; SLC25A1; SLC27A3; TECR; TECRL"
"R-HSA-5576886","Phase 4 - resting membrane potential",-0.359030466702558,0.320871403391547,0.263172892247743,17,"KCNJ12; KCNJ14; KCNJ2; KCNJ4; KCNK1; KCNK10; KCNK12; KCNK13; KCNK15; KCNK17; KCNK2; KCNK3; KCNK4; KCNK5; KCNK6; KCNK7; KCNK9"
"R-HSA-5689901","Metalloprotease DUBs",0.346013212426943,0.309797448912611,0.264036474900992,18,"BABAM1; BARD1; BRCA1; EP300; FAM175A; HIST1H2AG; HIST2H2AA3; HIST2H2AC; HIST3H2A; KAT2B; MYSM1; NLRP3; STAM; STAMBP; STAMBPL1; UBA52; UBC; UIMC1"
"R-HSA-5368286","Mitochondrial translation initiation",0.1999823402637,0.179065017712462,0.264073810061113,58,"AURKAIP1; CHCHD1; DAP3; ERAL1; MRPL1; MRPL10; MRPL11; MRPL12; MRPL13; MRPL14; MRPL16; MRPL17; MRPL18; MRPL19; MRPL2; MRPL20; MRPL21; MRPL22; MRPL23; MRPL24; MRPL27; MRPL28; MRPL32; MRPL33; MRPL34; MRPL35; MRPL36; MRPL37; MRPL38; MRPL39; MRPL4; MRPL40; MRPL41; MRPL42; MRPL43; MRPL44; MRPL46; MRPL47; MRPL48; MRPL50; MRPL51; MRPL52; MRPL54; MRPL55; MRPL58; MRPL9; MRPS10; MRPS12; MRPS14; MRPS15; MRPS16; MRPS17; MRPS18A; MRPS18B; MRPS18C; MRPS2; MRPS22; MRPS23"
"R-HSA-5673000","RAF activation",0.303270871488332,0.27156818335825,0.264105795683506,24,"BRAF; BRAP; HRAS; JAK2; KRAS; KSR1; MAP2K1; MAP2K2; MAP3K11; MARK3; NRAS; PHB; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5A; PPP2R5B; PPP2R5C; PPP2R5D; PPP2R5E; RAF1; SRC; YWHAB"
"R-HSA-5656169","Termination of translesion DNA synthesis",-0.288515931858075,0.259648401759548,0.266491175229311,27,"ISG15; PCLAF; PCNA; POLD1; POLD2; POLD3; POLE; POLE2; POLE3; POLE4; POLI; POLK; REV1; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3; TRIM25; UBA52; UBA7; UBC; UBE2L6; USP10"
"R-HSA-200425","Import of palmitoyl-CoA into the mitochondrial matrix",0.426008115001322,0.385933808861466,0.269663742190332,11,"CPT1A; CPT1B; CPT2; PPARD; PRKAA2; PRKAB2; PRKAG2; RXRA; SLC22A5; SLC25A20; THRSP"
"R-HSA-428930","Thromboxane signalling through TP receptor",0.325802097721844,0.295600263736687,0.270387249650375,20,"GNA11; GNA13; GNA14; GNA15; GNAQ; GNB1; GNB2; GNB3; GNB4; GNB5; GNG10; GNG11; GNG12; GNG2; GNG3; GNG4; GNG5; GNG7; GNGT2; TBXA2R"
"R-HSA-381033","ATF6 (ATF6-alpha) activates chaperones",0.443153971693775,0.402215756992423,0.270556575980983,10,"ATF4; ATF6; CALR; DDIT3; HSP90B1; MBTPS1; NFYA; NFYB; NFYC; XBP1"
"R-HSA-1483257","Phospholipid metabolism",-0.195381454316777,0.177594815685992,0.271265501394587,60,"ABHD3; ABHD4; ACHE; ACP6; AGK; AGPAT1; AGPAT2; AGPAT3; AGPAT4; AGPAT5; ARF3; BCHE; CDIPT; CDS1; CDS2; CEPT1; CHKA; CHKB; CHPT1; CPNE1; CPNE3; CPNE6; CPNE7; CRLS1; CSNK2A2; CSNK2B; DDHD1; DDHD2; DGAT1; DGAT2; ENPP6; ETNK1; ETNK2; ETNPPL; FIG4; GDE1; GDPD1; GDPD3; GDPD5; GNPAT; GPAM; GPAT2; GPAT3; GPAT4; GPCPD1; GPD1; GPD1L; GPD2; HADHA; HADHB; HRASLS; HRASLS2; HRASLS5; INPP4A; INPP4B; INPP5D; INPP5E; INPP5F; INPP5J; INPP5K"
"R-HSA-6811438","Intra-Golgi traffic",-0.236843309423541,0.215781512684453,0.272376113369631,40,"BET1L; COG1; COG2; COG3; COG4; COG5; COG6; COG7; COG8; CUX1; CYTH1; CYTH2; CYTH3; CYTH4; GOLGA5; GOLIM4; GOSR1; GOSR2; MAN1A1; MAN1A2; MAN1C1; MAN2A1; MAN2A2; NAPA; NAPB; NAPG; NSF; RAB30; RAB33B; RAB36; RGP1; RIC1; SNAP29; STX16; STX5; STX6; TRIP11; VPS45; VTI1A; YKT6"
"R-HSA-71240","Tryptophan catabolism",0.407534082020312,0.371919564640253,0.273184406247197,12,"AADAT; ACMSD; AFMID; HAAO; IDO1; IDO2; KYAT1; KYAT3; KYNU; SLC36A4; SLC7A5; TDO2"
"R-HSA-5654695","PI-3K cascade:FGFR2",0.357788009192923,0.327380564838445,0.274446037898116,16,"FGF1; FGF10; FGF17; FGF18; FGF2; FGF20; FGF22; FGF5; FGF7; FGF9; FGFR2; FRS2; GAB1; GRB2; PIK3CA; PIK3R1"
"R-HSA-425407","SLC-mediated transmembrane transport",-0.202181677547923,0.185238056224436,0.275066371698097,55,"AHCYL2; ALB; APOD; BSG; CALM1; CP; CTNS; EMB; LCN1; LCN12; LCN15; LCN9; MFSD4B; RHAG; RHBG; RHCG; SLC10A6; SLC11A1; SLC11A2; SLC12A1; SLC12A2; SLC12A4; SLC12A5; SLC12A6; SLC12A7; SLC13A2; SLC13A3; SLC13A4; SLC13A5; SLC14A1; SLC14A2; SLC15A1; SLC15A2; SLC15A3; SLC15A4; SLC16A1; SLC16A10; SLC16A3; SLC16A7; SLC16A8; SLC17A1; SLC17A5; SLC17A7; SLC18A1; SLC18A2; SLC1A1; SLC1A2; SLC1A3; SLC1A4; SLC1A5; SLC1A6; SLC1A7; SLC20A1; SLC20A2; SLC22A1"
"R-HSA-6783589","Interleukin-6 family signaling",-0.325713153694662,0.298707513334993,0.275533324535539,20,"CBL; CLCF1; CNTF; CNTFR; CRLF1; CTF1; IL11RA; IL31RA; IL6R; IL6ST; JAK1; JAK2; LIF; LIFR; OSM; OSMR; SOCS3; STAT1; STAT3; TYK2"
"R-HSA-2219530","Constitutive Signaling by Aberrant PI3K in Cancer",0.20558289370339,0.188826601025546,0.276268977411345,52,"BTC; CD19; CD28; CD80; CD86; EGF; EGFR; ERBB2; ERBB3; ERBB4; EREG; ESR1; ESR2; FGF1; FGF10; FGF17; FGF18; FGF2; FGF20; FGF22; FGF5; FGF7; FGF9; FGFR1; FGFR2; FGFR3; FGFR4; FRS2; FYN; GAB1; GRB2; HGF; IRS1; IRS2; KIT; KL; KLB; MET; NRG1; NRG4; PDGFB; PDGFRA; PDGFRB; PIK3AP1; PIK3CA; PIK3CB; PIK3CD; PIK3R1; PIK3R2; PIK3R3; SRC; VAV1"
"R-HSA-140837","Intrinsic Pathway of Fibrin Clot Formation",0.337818948949902,0.310511281714241,0.276619740475605,18,"A2M; C1QBP; F10; F11; F12; F2; GP1BA; GP5; KLKB1; KNG1; PRCP; PROC; SERPINA5; SERPINC1; SERPIND1; SERPINE2; SERPING1; VWF"
"R-HSA-5621481","C-type lectin receptors (CLRs)",0.203414886528744,0.187123985841254,0.27701056210776,53,"AHCYL1; BCL10; BTRC; CALM1; CARD11; CARD9; CASP8; CCL17; CCL22; CD209; CDC34; CHUK; CLEC10A; CLEC7A; CUL1; EP300; FBXW11; FCER1G; FYN; HRAS; ICAM2; ICAM3; IKBKB; IL1B; ITPR1; ITPR2; ITPR3; KRAS; LYN; MALT1; MAP3K7; MUC1; MUC12; MUC13; MUC15; MUC16; MUC20; MUC21; MUC3A; MUC4; MUC5B; MUC6; MUC7; MUCL1; NFATC1; NFATC3; NFKB1; NFKB2; NFKBIA; NRAS; PAK1; PAK2; PDPK1"
"R-HSA-8856825","Cargo recognition for clathrin-mediated endocytosis",0.196389578141422,0.180718100376838,0.27716154084285,57,"AAK1; ADRB2; AGFG1; AGTR1; AP2A1; AP2A2; AP2B1; AP2M1; AP2S1; APOB; ARRB1; ARRB2; CBL; CD3D; CD4; CFTR; CHRM2; CLTA; CLTB; CLTC; CLTCL1; COPS2; COPS3; COPS6; COPS7A; COPS7B; COPS8; DAB2; DVL2; EGF; EGFR; EPN1; EPN2; EPS15; EPS15L1; FCHO1; FCHO2; FZD4; GPS1; GRB2; GRK3; HGS; IGF2R; ITSN1; ITSN2; KIAA0319; LDLR; LDLRAP1; M6PR; NECAP2; NEDD8; PICALM; REPS1; SCARB2; SGIP1; SH3GL1; SH3GL2"
"R-HSA-2892247","POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation",0.420206942894209,0.386713888204954,0.277209472609863,11,"DPPA4; EPHA1; FGF2; FOXD3; NR6A1; POU5F1; SALL1; SALL4; SOX2; STAT3; TDGF1"
"R-HSA-427389","ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression",0.284630531578999,0.262155531224223,0.277597777408623,26,"CBX3; CHD3; CHD4; EHMT2; ERCC6; GATAD2A; GATAD2B; H2AFJ; H2AFV; H2AFX; H2AFZ; H2BFS; H3F3A; HDAC1; HDAC2; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HIST2H2AA3; HIST2H2AC; MBD3; MTA2; MTA3; RBBP4; TTF1"
"R-HSA-936964","Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon",0.389047988730964,0.359560677898536,0.279248406269647,13,"CD14; IRF3; IRF7; LY96; SARM1; TANK; TBK1; TICAM1; TICAM2; TLR4; TRAF3; UBA52; UBC"
"R-HSA-6782135","Dual incision in TC-NER",0.197153882271328,0.18228461732328,0.279442887985255,56,"AQR; CCNH; CDK7; CUL4A; DDB1; EP300; ERCC3; ERCC4; ERCC5; ERCC6; ERCC8; GTF2H1; GTF2H2; GTF2H3; GTF2H4; GTF2H5; HMGN1; ISY1; MNAT1; PCNA; POLD1; POLD2; POLD3; POLE; POLE2; POLE3; POLE4; POLK; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; PPIE; PRPF19; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3; TCEA1; UBA52; UBC; USP7; UVSSA; XAB2; XPA"
"R-HSA-190873","Gap junction degradation",0.436008274097547,0.403257058489311,0.279600722211589,10,"AP2M1; CLTA; CLTB; CLTC; CLTCL1; DAB2; DNM1; DNM2; GJA1; MYO6"
"R-HSA-5627117","RHO GTPases Activate ROCKs",0.335715542573008,0.310692212798961,0.279901528174599,18,"CFL1; LIMK1; LIMK2; MYH10; MYH11; MYH14; MYH9; MYL12B; MYL6; MYL9; PAK1; PPP1CB; PPP1R12A; PPP1R12B; RHOB; RHOC; ROCK1; ROCK2"
"R-HSA-199418","Negative regulation of the PI3K/AKT network",0.203879892565549,0.18888103885459,0.28040544226524,52,"AKT1; AKT2; AKT3; BTC; CD19; CD28; CD80; CD86; EGF; EGFR; ERBB2; ERBB3; ERBB4; EREG; ESR1; ESR2; FGF1; FGF10; FGF17; FGF18; FGF2; FGF20; FGF22; FGF5; FGF7; FGF9; FGFR1; FGFR2; FGFR3; FGFR4; FRS2; FYN; GAB1; GRB2; HGF; IER3; IL1RAP; IL1RL1; IL33; INSR; IRAK4; IRS1; IRS2; KIT; KL; KLB; MAPK1; MAPK3; MET; MYD88; NRG1; NRG4"
"R-HSA-456926","Thrombin signalling through proteinase activated receptors (PARs)",0.268243040478746,0.249237491049941,0.28181332753743,29,"ARRB1; ARRB2; F2; F2R; F2RL2; F2RL3; GNA11; GNA12; GNA13; GNA14; GNA15; GNAQ; GNB1; GNB2; GNB3; GNB4; GNB5; GNG10; GNG11; GNG12; GNG2; GNG3; GNG4; GNG5; GNG7; GNGT2; MAPK1; MAPK3; SRC"
"R-HSA-5619084","ABC transporter disorders",0.192450255092705,0.179283728335749,0.283073921337172,58,"ABCC8; CFTR; DERL1; DERL2; DERL3; ERLEC1; ERLIN1; ERLIN2; KCNJ11; OS9; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; RNF185; RNF5; SEL1L; SEM1; SFTPA1; SFTPA2; SFTPB; SFTPC; SFTPD; UBA52; UBC; VCP"
"R-HSA-5654219","Phospholipase C-mediated cascade: FGFR1",0.414247252965816,0.387506269940292,0.28506612234489,11,"FGF1; FGF10; FGF17; FGF2; FGF20; FGF22; FGF5; FGF9; FGFR1; KL; PLCG1"
"R-HSA-8873719","RAB geranylgeranylation",0.198194909257166,0.185562341230253,0.285485681314185,54,"CHML; PTP4A2; RAB10; RAB11A; RAB11B; RAB12; RAB13; RAB14; RAB15; RAB17; RAB18; RAB19; RAB1A; RAB20; RAB22A; RAB23; RAB24; RAB25; RAB26; RAB27A; RAB27B; RAB29; RAB2A; RAB2B; RAB30; RAB31; RAB32; RAB33B; RAB34; RAB35; RAB36; RAB37; RAB38; RAB3A; RAB3B; RAB3C; RAB3D; RAB40B; RAB40C; RAB42; RAB43; RAB44; RAB4A; RAB4B; RAB5A; RAB5B; RAB5C; RAB6A; RAB6B; RAB7A; RAB8A; RAB8B; RABGGTA; RABGGTB"
"R-HSA-2173795","Downregulation of SMAD2/3:SMAD4 transcriptional activity",-0.326818446039734,0.30635877190309,0.286069665477728,19,"HDAC1; NCOR1; NEDD4L; PARP1; PPM1A; RNF111; SKI; SKIL; SMAD2; SMAD3; SMAD4; SMURF2; TGIF1; TGIF2; TRIM33; UBA52; UBC; UBE2D1; UBE2D3"
"R-HSA-69239","Synthesis of DNA",0.191216135521382,0.180868283167508,0.290414803684232,57,"CCNA1; CCNA2; CDC45; CDC6; CDK2; CDKN1B; CDT1; DNA2; FZR1; GINS1; GINS2; GINS3; LIG1; MCM2; MCM3; MCM4; MCM5; MCM6; MCM7; MCM8; ORC1; ORC3; ORC4; ORC5; ORC6; PCNA; POLA2; POLD1; POLD2; POLD3; POLE; POLE2; POLE3; POLE4; PRIM1; PRIM2; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1"
"R-HSA-425410","Metal ion SLC transporters",0.298831403537227,0.283883597839473,0.292499277417885,22,"CP; SLC11A1; SLC11A2; SLC30A1; SLC30A10; SLC30A2; SLC30A5; SLC30A6; SLC30A8; SLC31A1; SLC39A1; SLC39A10; SLC39A14; SLC39A2; SLC39A3; SLC39A4; SLC39A5; SLC39A6; SLC39A8; SLC40A1; SLC41A1; SLC41A2"
"R-HSA-1660499","Synthesis of PIPs at the plasma membrane",0.213055716932283,0.202608809745281,0.293000568550012,45,"INPP4A; INPP4B; INPP5D; INPP5J; INPP5K; INPPL1; MTMR14; MTMR2; MTMR3; MTMR6; MTMR9; PI4K2A; PI4K2B; PIK3C2A; PIK3C2B; PIK3C2G; PIK3CA; PIK3CB; PIK3CD; PIK3CG; PIK3R1; PIK3R2; PIK3R3; PIK3R5; PIP4K2A; PIP4K2C; PIP5K1A; PIP5K1B; PIP5K1C; PLEKHA1; PLEKHA2; PLEKHA3; PLEKHA4; PLEKHA5; PLEKHA6; PLEKHA8; PTEN; PTPN13; RAB14; RAB4A; RAB5A; RUFY1; SBF2; SYNJ1; SYNJ2"
"R-HSA-975577","N-Glycan antennae elongation",-0.369405061782523,0.352292312360425,0.294373570510962,14,"B4GALT1; B4GALT2; B4GALT3; B4GALT4; B4GALT5; B4GALT6; MGAT4A; MGAT4B; MGAT4C; MGAT5; ST3GAL4; ST6GAL1; ST8SIA2; ST8SIA6"
"R-HSA-74160","Gene expression (Transcription)",0.199694007278801,0.190857419116086,0.295422812265543,51,"ABL1; ACTL6A; AEBP2; AFF4; AGO1; AGO2; AGO3; AGO4; AIFM2; AKT1; AKT2; AKT3; ALYREF; APAF1; ARID1B; ARID2; ARID3A; ARID4B; ATAD2; ATF2; ATM; ATR; ATRIP; AURKA; AURKB; AUTS2; AXIN1; BANP; BARD1; BAX; BAZ1B; BAZ2A; BBC3; BCDIN3D; BCL2L11; BCL2L14; BDP1; BGLAP; BID; BIRC5; BLK; BLM; BMI1; BNIP3L; BRCA1; BRD2; BRD7; BRF1; BRF2; BRIP1; BRPF3"
"R-HSA-8950505","Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation",0.248815323922402,0.238328365267096,0.296484398448404,32,"AIP; ANXA2; BOLA2; CA1; CAPZA1; CDC42; CFL1; CNN2; FOXO3; GSTA2; GSTO1; HNRNPDL; HNRNPF; IL10; LMNB1; MIF; MTAP; PAK2; PDCD4; PITPNA; PPIA; PSME2; RALA; RAP1B; RPLP0; SERPINB2; SNRPA1; SOD1; SOD2; STAT4; TALDO1; TCP1"
"R-HSA-1971475","A tetrasaccharide linker sequence is required for GAG synthesis",-0.298958307735711,0.286781306092787,0.297198029237362,22,"AGRN; B3GALT6; B3GAT1; B3GAT2; B3GAT3; B4GALT7; BCAN; CSPG4; CSPG5; DCN; GPC1; GPC2; GPC5; GPC6; HSPG2; SDC1; SDC2; SDC3; SDC4; VCAN; XYLT1; XYLT2"
"R-HSA-5693538","Homology Directed Repair",0.202654557300103,0.194582437849966,0.297650828323512,49,"ABL1; ATM; ATR; ATRIP; BABAM1; BARD1; BLM; BRCA1; BRCA2; BRIP1; CCNA1; CCNA2; CDK2; CHEK1; DNA2; EME1; EME2; ERCC4; EXO1; FAM175A; GEN1; H2AFX; H2BFS; HERC2; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HUS1; KAT5; LIG3; MDC1; MRE11; MUS81; NBN; PALB2; PARP1; PARP2; PCNA; PIAS4; POLD1; POLD2; POLD3; POLE; POLE2; POLE3; POLE4; POLK; POLQ"
"R-HSA-373760","L1CAM interactions",0.185345972167669,0.177972361815268,0.297675463766922,59,"ALCAM; ANK1; ANK2; ANK3; AP2A1; AP2A2; AP2B1; AP2M1; AP2S1; CHL1; CLTA; CLTC; CNTN1; CNTN2; CNTN6; CNTNAP1; CSNK2A2; CSNK2B; DLG1; DLG4; DNM1; DNM2; DNM3; DPYSL2; EGFR; EPHB2; EZR; FGFR1; GAP43; HSPA8; ITGA1; ITGA10; ITGA2; ITGA2B; ITGA5; ITGA9; ITGAV; ITGB1; ITGB3; KCNQ2; KCNQ3; LAMA1; LAMB1; LAMC1; LYPLA2; MAP2K1; MAP2K2; MAPK1; MAPK3; NCAM1; NFASC; NRCAM; NRP1; NRP2; NUMB; PAK1; RAC1; RANBP9; RDX"
"R-HSA-5619115","Disorders of transmembrane transporters",0.189927922906689,0.18249625085036,0.298004437778364,56,"ABCC8; ALB; AVPR1A; CFTR; DERL1; DERL2; DERL3; ERLEC1; ERLIN1; ERLIN2; GCK; GCKR; KCNJ11; OS9; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; RNF185; RNF5; SEL1L; SEM1; SFTPA1; SFTPA2"
"R-HSA-1638074","Keratan sulfate/keratin metabolism",-0.249777526676156,0.240509093677581,0.299020246386318,32,"ACAN; B3GNT2; B3GNT3; B3GNT4; B3GNT7; B4GALT1; B4GALT2; B4GALT3; B4GALT4; B4GALT5; B4GALT6; B4GAT1; CHST1; CHST2; CHST5; CHST6; FMOD; GLB1; GLB1L; GNS; HEXA; HEXB; KERA; LUM; OGN; OMD; PRELP; SLC35D2; ST3GAL1; ST3GAL3; ST3GAL4; ST3GAL6"
"R-HSA-4791275","Signaling by WNT in cancer",0.255102973795092,0.24577142819138,0.299284771376439,30,"APC; AXIN1; CSNK1A1; CTBP1; CTBP2; CTNNB1; DKK1; DKK4; FZD4; FZD5; FZD6; FZD8; GSK3B; KREMEN1; KREMEN2; LRP5; LRP6; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5A; PPP2R5B; PPP2R5C; PPP2R5D; PPP2R5E; RNF43; TCF7L2; TNKS; TNKS2"
"R-HSA-174411","Polymerase switching on the C-strand of the telomere",-0.391150391602545,0.377707970339892,0.300393713026232,12,"PCNA; POLA2; POLD1; POLD2; POLD3; PRIM1; PRIM2; RFC1; RFC2; RFC3; RFC4; RFC5"
"R-HSA-69091","Polymerase switching",-0.391150391602545,0.377707970339892,0.300393713026232,12,"PCNA; POLA2; POLD1; POLD2; POLD3; PRIM1; PRIM2; RFC1; RFC2; RFC3; RFC4; RFC5"
"R-HSA-69109","Leading Strand Synthesis",-0.391150391602545,0.377707970339892,0.300393713026232,12,"PCNA; POLA2; POLD1; POLD2; POLD3; PRIM1; PRIM2; RFC1; RFC2; RFC3; RFC4; RFC5"
"R-HSA-5668541","TNFR2 non-canonical NF-kB pathway",0.195705736819905,0.18913715250036,0.300795389586412,52,"BIRC2; BIRC3; BTRC; CD27; CD40; CD70; CHUK; CUL1; EDARADD; FBXW11; LTA; LTBR; NFKB2; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; SEM1; SKP1; TNF"
"R-HSA-3108214","SUMOylation of DNA damage response and repair proteins",-0.18242139809639,0.176431194297876,0.301158571983076,61,"BLM; BMI1; BRCA1; CBX2; CBX4; CBX8; CDKN2A; EID3; HDAC7; HERC2; MDC1; NDC1; NSMCE1; NSMCE2; NSMCE3; NSMCE4A; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188; NUP205; NUP210; NUP214; NUP35; NUP43; NUP50; NUP54; NUP58; NUP62; NUP85; NUP88; NUP93; NUP98; NUPL2; PARP1; PHC1; PHC2; PHC3; PIAS1; PIAS2; PIAS4; PML; POM121; RAD21; RAD52; RAE1; RANBP2; RING1; RNF168; RNF2; RPA1; SCMH1; SEH1L; SMC3; SMC5; SMC6; SP100; STAG1; SUMO1"
"R-HSA-5628897","TP53 Regulates Metabolic Genes",-0.191430844104574,0.185499417724055,0.302083620820354,55,"AGO1; AGO2; AGO3; AGO4; AKT1; AKT2; AKT3; COX11; COX14; COX16; COX18; COX19; COX20; COX4I1; COX5A; COX5B; COX6A1; COX6B1; COX6C; COX7A2L; COX8A; CYCS; DDIT4; GLS; GPI; GPX2; GSR; LAMTOR2; LAMTOR3; LAMTOR4; LAMTOR5; LRPPRC; MLST8; MOV10; MTOR; NDUFA4; PRDX1; PRDX2; PRDX5; PRKAA1; PRKAA2; PRKAB1; PRKAB2; PRKAG1; PRKAG2; PTEN; RHEB; RPTOR; RRAGA; RRAGC; RRAGD; RRM2B; SCO1; SCO2; SESN2"
"R-HSA-68882","Mitotic Anaphase",-0.191341507823451,0.18550151716181,0.302314764339193,55,"AHCTF1; ANAPC1; ANAPC10; ANAPC11; ANAPC15; ANAPC16; ANAPC2; ANAPC4; ANAPC5; ANAPC7; ANKLE2; AURKB; B9D2; BANF1; BIRC5; BUB1B; BUB3; CDC16; CDC26; CDC27; CDCA5; CENPA; CENPC; CENPE; CENPF; CENPH; CENPK; CENPL; CENPM; CENPN; CENPO; CENPP; CENPQ; CENPT; CENPU; CKAP5; CLASP1; CLIP1; DSN1; DYNC1H1; DYNC1I1; DYNC1I2; DYNC1LI1; DYNC1LI2; DYNLL1; DYNLL2; ESPL1; INCENP; ITGB3BP; KIF2A; KIF2C; KNTC1; LEMD2; LEMD3; LMNA"
"R-HSA-1489509","DAG and IP3 signaling",-0.272553218732698,0.265467878038982,0.304566454181481,26,"ADCY1; ADCY2; ADCY3; ADCY4; ADCY5; ADCY6; ADCY7; ADCY9; AHCYL1; CALM1; CAMK4; ITPR1; ITPR2; ITPR3; PDE1A; PDE1B; PDE1C; PLCG1; PRKACB; PRKAR1A; PRKAR1B; PRKAR2A; PRKAR2B; PRKCA; PRKCD; PRKCE"
"R-HSA-381042","PERK regulates gene expression",0.269979813771746,0.263036124290932,0.304703909548033,26,"ASNS; ATF3; ATF4; ATF6; CCL2; CXCL8; DCP2; DDIT3; DIS3; EIF2AK3; EIF2S1; EXOSC1; EXOSC2; EXOSC3; EXOSC4; EXOSC5; EXOSC6; EXOSC7; EXOSC8; EXOSC9; HERPUD1; IGFBP1; NFYA; NFYB; NFYC; PARN"
"R-HSA-8948751","Regulation of PTEN stability and activity",0.185533287572565,0.181029479272872,0.305420347365073,57,"AKT1; AKT2; AKT3; CSNK2A2; CSNK2B; FRK; MKRN1; NEDD4; OTUD3; PREX2; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; PTEN; RNF146; SEM1; STUB1; TNKS; TNKS2; TRIM27; UBA52; UBC; USP13; WWP2"
"R-HSA-1632852","Macroautophagy",-0.183618518588883,0.179339182325014,0.305900606603364,59,"ATG10; ATG101; ATG12; ATG13; ATG14; ATG16L1; ATG4B; ATG4C; ATG4D; ATG5; ATG7; ATG9A; ATG9B; BECN1; CHMP2A; CHMP2B; CHMP3; CHMP4A; CHMP4B; CHMP4C; CHMP6; CHMP7; DYNLL1; DYNLL2; GABARAP; GABARAPL1; GABARAPL2; LAMTOR2; LAMTOR3; LAMTOR4; LAMTOR5; MAP1LC3A; MAP1LC3B; MAP1LC3C; MLST8; MTMR14; MTMR3; MTOR; PIK3C3; PIK3R4; PRKAA1; PRKAA2; PRKAB1; PRKAB2; PRKAG1; PRKAG2; RHEB; RPTOR; RRAGA; RRAGC; RRAGD; SLC38A9; TSC1; TSC2; ULK1; UVRAG; WDR45B; WIPI1; WIPI2"
"R-HSA-351906","Apoptotic cleavage of cell adhesion  proteins",0.396625119211892,0.389795167383452,0.308905219660302,11,"CASP3; CDH1; CTNNB1; DSG1; DSG2; DSG3; DSP; OCLN; PKP1; TJP1; TJP2"
"R-HSA-1963642","PI3K events in ERBB2 signaling",0.367772148454157,0.361953493389281,0.309593340600422,13,"BTC; EGF; EGFR; ERBB2; ERBB3; ERBB4; EREG; GAB1; GRB2; NRG1; NRG4; PIK3CA; PIK3R1"
"R-HSA-1227986","Signaling by ERBB2",0.207678916911965,0.205072362229014,0.311198501995825,44,"AKT1; AKT2; AKT3; BTC; CDC37; CUL5; DIAPH1; EGF; EGFR; ERBB2; ERBB3; ERBB4; ERBIN; EREG; FYN; GAB1; GRB2; GRB7; HRAS; HSP90AA1; KRAS; MATK; MEMO1; NRAS; NRG1; NRG4; PIK3CA; PIK3R1; PLCG1; PRKCA; PRKCD; PRKCE; PTK6; PTPN12; PTPN18; RNF41; SHC1; SOS1; SRC; STUB1; UBA52; UBC; USP8; YES1"
"R-HSA-5696395","Formation of Incision Complex in GG-NER",0.234504037696941,0.231922778001124,0.311954297736812,34,"CCNH; CDK7; CHD1L; CUL4A; DDB1; DDB2; ERCC3; ERCC4; ERCC5; GTF2H1; GTF2H2; GTF2H3; GTF2H4; GTF2H5; MNAT1; PARP1; PARP2; PIAS1; PIAS3; RAD23B; RNF111; RPA1; RPA2; RPA3; SUMO1; SUMO2; SUMO3; UBA52; UBC; UBE2I; UBE2N; USP45; XPA; XPC"
"R-HSA-389661","Glyoxylate metabolism and glycine degradation",-0.273405695920186,0.270646203078157,0.31240142334954,25,"AGXT; ALDH4A1; AMT; BCKDHA; BCKDHB; DBT; DDO; DHTKD1; DLAT; DLD; DLST; GCSH; GLDC; GNMT; GOT2; GRHPR; HOGA1; LIAS; LIPT1; LIPT2; NDUFAB1; OGDH; PDHB; PDHX; PXMP2"
"R-HSA-4551638","SUMOylation of chromatin organization proteins",0.194456431427621,0.192905328253535,0.313434900637568,50,"BMI1; CBX2; CBX4; CBX5; CBX8; CHD3; HDAC1; HDAC2; HDAC4; L3MBTL2; NDC1; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188; NUP205; NUP210; NUP214; NUP35; NUP43; NUP50; NUP54; NUP58; NUP62; NUP85; NUP88; NUP93; NUP98; NUPL2; PHC1; PHC2; PHC3; PIAS1; PIAS2; POM121; RAE1; RANBP2; RING1; RNF2; SATB1; SATB2; SCMH1; SEH1L; SUMO1; SUMO2; SUMO3; SUZ12; UBE2I"
"R-HSA-111931","PKA-mediated phosphorylation of CREB",-0.367476647992439,0.365748239935488,0.315028960548161,13,"ADCY1; ADCY2; ADCY3; ADCY4; ADCY5; ADCY6; ADCY7; ADCY9; PRKACB; PRKAR1A; PRKAR1B; PRKAR2A; PRKAR2B"
"R-HSA-163615","PKA activation",-0.367476647992439,0.365748239935488,0.315028960548161,13,"ADCY1; ADCY2; ADCY3; ADCY4; ADCY5; ADCY6; ADCY7; ADCY9; PRKACB; PRKAR1A; PRKAR1B; PRKAR2A; PRKAR2B"
"R-HSA-264870","Caspase-mediated cleavage of cytoskeletal proteins",-0.395637173893963,0.393824049122149,0.315087620756196,11,"ADD1; CASP3; CASP6; CASP7; CASP8; DBNL; GAS2; GSN; MAPT; PLEC; VIM"
"R-HSA-112310","Neurotransmitter release cycle",-0.214850766545851,0.213902327499152,0.315169477417446,41,"ABAT; ALDH5A1; APBA1; ARL6IP5; CPLX1; GAD1; GLS; HSPA8; LIN7A; LIN7B; LIN7C; NAAA; PPFIA1; PPFIA2; PPFIA3; PPFIA4; RAB3A; RIMS1; SLC17A7; SLC18A2; SLC18A3; SLC1A1; SLC1A2; SLC1A3; SLC1A6; SLC1A7; SLC22A1; SLC22A2; SLC5A7; SLC6A1; SLC6A11; SLC6A12; SLC6A13; SNAP25; STX1A; STXBP1; SYN3; SYT1; TSPOAP1; UNC13B; VAMP2"
"R-HSA-5654719","SHC-mediated cascade:FGFR4",0.351981369970245,0.350478475665304,0.315239757446263,14,"FGF1; FGF17; FGF18; FGF2; FGF20; FGF9; FGFR4; GRB2; HRAS; KLB; KRAS; NRAS; SHC1; SOS1"
"R-HSA-452723","Transcriptional regulation of pluripotent stem cells",0.229067655484729,0.228847432033103,0.316845027539021,35,"CDX2; DKK1; DPPA4; EOMES; EPAS1; EPHA1; FGF2; FOXD3; FOXP1; GSC; HHEX; HIF3A; NR6A1; PBX1; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; POU5F1; SALL1; SALL4; SMAD2; SMAD4; SOX2; STAT3; TDGF1; TSC22D1; ZSCAN10"
"R-HSA-211999","CYP2E1 reactions",0.407062462179266,0.407335106428209,0.317634535937678,10,"CYP2A13; CYP2A6; CYP2A7; CYP2C19; CYP2C8; CYP2C9; CYP2D6; CYP2E1; CYP2F1; CYP2S1"
"R-HSA-5689880","Ub-specific processing proteases",0.198397895675488,0.198785358978338,0.318254703630592,47,"ADRB2; ADRM1; ARRB1; ARRB2; ATXN7; AXIN1; AXIN2; BECN1; BIRC2; BIRC3; CCNA1; CCNA2; CCP110; CDC25A; CFTR; CYLD; DDB2; DDX58; FKBP8; GATA3; HGS; HIF1A; HIST1H2AG; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HIST2H2AA3; HIST2H2AC; HIST2H2BF; HIST3H2A; IDE; IFIH1; IL33; KAT2A; KEAP1; MAP3K7; MAT2B; MDM2; MDM4; MUL1; MYC; NFKBIA; OTUB1; POLB; PSMA1; PSMA2"
"R-HSA-190861","Gap junction assembly",0.404981035370254,0.407619550849168,0.320453192280773,10,"GJA1; GJA3; GJA4; GJB2; GJB3; GJB4; GJB5; GJB6; GJC1; GJD2"
"R-HSA-5632684","Hedgehog 'on' state",0.177037995470356,0.178196293389515,0.320466410641296,59,"ARRB1; ARRB2; BOC; CDC73; CDON; CSNK1A1; CUL3; DHH; DZIP1; EFCAB7; EVC; EVC2; GAS1; GAS8; GLI1; GLI2; GLI3; GPR161; HHIP; IHH; IQCE; ITCH; KIF3A; KIF7; NUMB; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3"
"R-HSA-380994","ATF4 activates genes",0.271749742741442,0.273606387022698,0.320605590499593,24,"ASNS; ATF3; ATF4; ATF6; CCL2; CXCL8; DCP2; DDIT3; DIS3; EXOSC1; EXOSC2; EXOSC3; EXOSC4; EXOSC5; EXOSC6; EXOSC7; EXOSC8; EXOSC9; HERPUD1; IGFBP1; NFYA; NFYB; NFYC; PARN"
"R-HSA-1855204","Synthesis of IP3 and IP4 in the cytosol",-0.268315381659337,0.270929130472244,0.322001781797374,25,"CALM1; INPP5B; INPP5D; INPP5J; INPPL1; ITPK1; ITPKA; ITPKB; ITPKC; PLCB1; PLCB2; PLCB3; PLCB4; PLCD1; PLCD3; PLCD4; PLCE1; PLCG1; PLCG2; PLCH1; PLCH2; PLCZ1; PLD4; PTEN; SYNJ1"
"R-HSA-6802949","Signaling by RAS mutants",0.194877521059636,0.196835087089635,0.322147338841304,48,"APBB1IP; ARRB1; ARRB2; BRAF; BRAP; CNKSR1; CSK; DAB2IP; FGA; FGB; FGG; FN1; HRAS; IQGAP1; ITGA2B; ITGB3; JAK2; KRAS; KSR1; KSR2; MAP2K1; MAP2K2; MAP3K11; MAPK1; MAPK3; MARK3; NF1; NRAS; PEBP1; PHB; RAF1; RAP1A; RAP1B; RASA1; RASA2; RASA3; RASA4; RASAL1; RASAL2; RASAL3; SPRED1; SPRED2; SPRED3; SRC; TLN1; VCL; VWF; YWHAB"
"R-HSA-2995383","Initiation of Nuclear Envelope Reformation",-0.374746045353955,0.379747439256044,0.323726140189589,12,"ANKLE2; BANF1; LEMD2; LEMD3; LMNA; LMNB1; PPP2CA; PPP2R1A; PPP2R2A; TMPO; VRK1; VRK2"
"R-HSA-2995410","Nuclear Envelope Reassembly",-0.374746045353955,0.379747439256044,0.323726140189589,12,"ANKLE2; BANF1; LEMD2; LEMD3; LMNA; LMNB1; PPP2CA; PPP2R1A; PPP2R2A; TMPO; VRK1; VRK2"
"R-HSA-73762","RNA Polymerase I Transcription Initiation",0.206810819294198,0.209891783569487,0.324466333616643,42,"CCNH; CDK7; CHD3; CHD4; EHMT2; ERCC3; ERCC6; GATAD2A; GATAD2B; GTF2H1; GTF2H2; GTF2H3; GTF2H4; GTF2H5; HDAC1; HDAC2; KAT2A; KAT2B; MBD3; MNAT1; MTA2; MTA3; POLR1A; POLR1B; POLR1C; POLR1D; POLR1E; POLR2E; POLR2F; POLR2H; POLR2K; POLR2L; RBBP4; RRN3; TAF1A; TAF1B; TAF1C; TAF1D; TBP; TTF1; TWISTNB; ZNRD1"
"R-HSA-5696397","Gap-filling DNA repair synthesis and ligation in GG-NER",-0.283294237424006,0.287798127114942,0.324943195306666,22,"LIG1; LIG3; PCNA; POLD1; POLD2; POLD3; POLE; POLE2; POLE3; POLE4; POLK; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3; UBA52; UBC; XRCC1"
"R-HSA-382556","ABC-family proteins mediated transport",0.178195325625715,0.181231753355826,0.325486572640024,57,"ABCA10; ABCA2; ABCA3; ABCA4; ABCA5; ABCA6; ABCA7; ABCA8; ABCA9; ABCB1; ABCB10; ABCB4; ABCB6; ABCB8; ABCB9; ABCC1; ABCC10; ABCC11; ABCC2; ABCC3; ABCC4; ABCC5; ABCC6; ABCC8; ABCC9; ABCD2; ABCD3; ABCF1; ABCG1; ABCG4; ABCG5; ABCG8; APOA1; CFTR; DERL1; DERL2; DERL3; EIF2S1; EIF2S2; ERLEC1; ERLIN1; ERLIN2; KCNJ11; OS9; PEX3; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7"
"R-HSA-110320","Translesion Synthesis by POLH",-0.337348963024725,0.343622350571921,0.32622629533919,15,"NPLOC4; PCNA; RCHY1; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3; SPRTN; UBA52; UBC; VCP"
"R-HSA-5651801","PCNA-Dependent Long Patch Base Excision Repair",-0.302069562026556,0.308264494176183,0.327133586576254,19,"APEX1; LIG1; PCNA; POLB; POLD1; POLD2; POLD3; POLE; POLE2; POLE3; POLE4; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3"
"R-HSA-1433557","Signaling by SCF-KIT",0.209978947477654,0.214917319128712,0.3285582643785,40,"CBL; CHEK1; CMA1; FER; FES; FYN; GAB2; GRAP; GRAP2; GRB10; GRB2; GRB7; HRAS; JAK2; KIT; KRAS; LYN; MMP9; NRAS; PIK3CA; PIK3R1; PIK3R2; PIK3R3; PRKCA; PTPN6; PTPRU; RAC1; SH2B2; SH2B3; SOCS1; SOCS6; SOS1; SRC; STAT1; STAT3; STAT5A; STAT5B; TEC; VAV1; YES1"
"R-HSA-392517","Rap1 signalling",0.354365584184187,0.363403663001771,0.329496092699974,13,"PRKACB; PRKG1; RAF1; RAP1A; RAP1B; RAP1GAP; RAP1GAP2; RAPGEF3; RAPGEF4; RASGRP1; SIPA1; YWHAB; YWHAZ"
"R-HSA-5654743","Signaling by FGFR4",0.236360077125648,0.242726154303338,0.330169463153619,31,"BRAF; CBL; FGF1; FGF17; FGF18; FGF2; FGF20; FGF9; FGFR4; FRS2; FRS3; GAB1; GRB2; HRAS; KLB; KRAS; MAPK1; MAPK3; MKNK1; NRAS; PIK3CA; PIK3R1; PLCG1; PPP2CA; PPP2CB; PPP2R1A; SHC1; SOS1; SRC; UBA52; UBC"
"R-HSA-5675221","Negative regulation of MAPK pathway",0.223076374622238,0.229106055820921,0.330214604840307,35,"BRAF; BRAP; DUSP1; DUSP10; DUSP16; DUSP2; DUSP4; DUSP5; DUSP7; DUSP8; HRAS; KRAS; KSR1; MAP2K1; MAP2K2; MAPK1; MAPK3; MARK3; NRAS; PAQR3; PEBP1; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5A; PPP2R5B; PPP2R5C; PPP2R5D; PPP2R5E; PPP5C; RAF1; UBA52; UBC; YWHAB"
"R-HSA-4839743","phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex",0.341846398290001,0.351498426393418,0.330781807519386,14,"APC; AXIN1; CSNK1A1; CTNNB1; GSK3B; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5A; PPP2R5B; PPP2R5C; PPP2R5D; PPP2R5E"
"R-HSA-5339716","Misspliced GSK3beta mutants stabilize beta-catenin",0.341846398290001,0.351498426393418,0.330781807519386,14,"APC; AXIN1; CSNK1A1; CTNNB1; GSK3B; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5A; PPP2R5B; PPP2R5C; PPP2R5D; PPP2R5E"
"R-HSA-5358747","S33 mutants of beta-catenin aren't phosphorylated",0.341846398290001,0.351498426393418,0.330781807519386,14,"APC; AXIN1; CSNK1A1; CTNNB1; GSK3B; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5A; PPP2R5B; PPP2R5C; PPP2R5D; PPP2R5E"
"R-HSA-5358749","S37 mutants of beta-catenin aren't phosphorylated",0.341846398290001,0.351498426393418,0.330781807519386,14,"APC; AXIN1; CSNK1A1; CTNNB1; GSK3B; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5A; PPP2R5B; PPP2R5C; PPP2R5D; PPP2R5E"
"R-HSA-5358751","S45 mutants of beta-catenin aren't phosphorylated",0.341846398290001,0.351498426393418,0.330781807519386,14,"APC; AXIN1; CSNK1A1; CTNNB1; GSK3B; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5A; PPP2R5B; PPP2R5C; PPP2R5D; PPP2R5E"
"R-HSA-5358752","T41 mutants of beta-catenin aren't phosphorylated",0.341846398290001,0.351498426393418,0.330781807519386,14,"APC; AXIN1; CSNK1A1; CTNNB1; GSK3B; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5A; PPP2R5B; PPP2R5C; PPP2R5D; PPP2R5E"
"R-HSA-5389840","Mitochondrial translation elongation",0.174766499920445,0.179770181270575,0.330967856307666,58,"AURKAIP1; CHCHD1; DAP3; ERAL1; GFM1; MRPL1; MRPL10; MRPL11; MRPL12; MRPL13; MRPL14; MRPL16; MRPL17; MRPL18; MRPL19; MRPL2; MRPL20; MRPL21; MRPL22; MRPL23; MRPL24; MRPL27; MRPL28; MRPL32; MRPL33; MRPL34; MRPL35; MRPL36; MRPL37; MRPL38; MRPL39; MRPL4; MRPL40; MRPL41; MRPL42; MRPL43; MRPL44; MRPL46; MRPL47; MRPL48; MRPL50; MRPL51; MRPL52; MRPL54; MRPL55; MRPL58; MRPL9; MRPS10; MRPS12; MRPS14; MRPS15; MRPS16; MRPS17; MRPS18A; MRPS18B; MRPS18C; MRPS2; MRPS22"
"R-HSA-187687","Signalling to ERKs",0.235982059351703,0.242744225432469,0.330979495045522,31,"BRAF; CRK; CRKL; FRS2; GRB2; HRAS; KIDINS220; KRAS; MAPK11; MAPK12; MAPK13; MAPK14; MAPKAPK2; MAPKAPK3; NGF; NRAS; NTRK1; PLCG1; RALA; RALB; RALGDS; RAP1A; RAPGEF1; RIT1; RIT2; SHC1; SHC2; SHC3; SOS1; SRC; YWHAB"
"R-HSA-2559580","Oxidative Stress Induced Senescence",0.191141411000614,0.196954108072354,0.331803777648392,48,"AGO1; AGO3; AGO4; BMI1; CBX2; CBX4; CBX6; CBX8; CDK4; CDK6; CDKN2A; CDKN2B; CDKN2C; CDKN2D; E2F1; E2F2; EED; EZH2; FOS; H2AFJ; H2AFV; H2AFX; H2AFZ; H2BFS; H3F3A; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HIST2H2AA3; HIST2H2AC; KDM6B; MAP2K3; MAP2K4; MAP2K6; MAP2K7; MAP3K5; MAP4K4; MAPK1; MAPK10; MAPK11; MAPK14; MAPK3; MAPK8; MAPK9; MAPKAPK2; MAPKAPK3; MAPKAPK5"
"R-HSA-72613","Eukaryotic Translation Initiation",-0.1778156571599,0.18415598079209,0.334258939640279,56,"EIF2B1; EIF2B2; EIF2B3; EIF2B5; EIF2S1; EIF2S2; EIF3A; EIF3B; EIF3C; EIF3D; EIF3E; EIF3F; EIF3G; EIF3H; EIF3I; EIF3J; EIF3K; EIF3L; EIF3M; EIF4A1; EIF4A2; EIF4B; EIF4E; EIF4G1; EIF4H; EIF5; EIF5B; FAU; PABPC1; RPL10A; RPL12; RPL13; RPL13A; RPL14; RPL15; RPL17; RPL18; RPL18A; RPL19; RPL21; RPL22L1; RPL23A; RPL26; RPL26L1; RPL27A; RPL28; RPL29; RPL3; RPL30; RPL31; RPL32; RPL34; RPL35; RPL35A; RPL36; RPL36AL"
"R-HSA-72737","Cap-dependent Translation Initiation",-0.1778156571599,0.18415598079209,0.334258939640279,56,"EIF2B1; EIF2B2; EIF2B3; EIF2B5; EIF2S1; EIF2S2; EIF3A; EIF3B; EIF3C; EIF3D; EIF3E; EIF3F; EIF3G; EIF3H; EIF3I; EIF3J; EIF3K; EIF3L; EIF3M; EIF4A1; EIF4A2; EIF4B; EIF4E; EIF4G1; EIF4H; EIF5; EIF5B; FAU; PABPC1; RPL10A; RPL12; RPL13; RPL13A; RPL14; RPL15; RPL17; RPL18; RPL18A; RPL19; RPL21; RPL22L1; RPL23A; RPL26; RPL26L1; RPL27A; RPL28; RPL29; RPL3; RPL30; RPL31; RPL32; RPL34; RPL35; RPL35A; RPL36; RPL36AL"
"R-HSA-1483255","PI Metabolism",0.170248352812125,0.176895929156443,0.335838181061863,60,"ARF3; ENPP6; FIG4; GDE1; GDPD1; GDPD3; GDPD5; INPP4A; INPP4B; INPP5D; INPP5E; INPP5F; INPP5J; INPP5K; INPPL1; MTMR10; MTMR12; MTMR14; MTMR2; MTMR3; MTMR4; MTMR6; MTMR7; MTMR9; PI4K2A; PI4K2B; PI4KA; PI4KB; PIK3C2A; PIK3C2B; PIK3C2G; PIK3C3; PIK3CA; PIK3CB; PIK3CD; PIK3CG; PIK3R1; PIK3R2; PIK3R3; PIK3R4; PIK3R5; PIKFYVE; PIP4K2A; PIP4K2C; PIP5K1A; PIP5K1B; PIP5K1C; PITPNB; PLEKHA1; PLEKHA2; PLEKHA3; PLEKHA4; PLEKHA5; PLEKHA6; PLEKHA8; PNPLA6; PNPLA7; PTEN; PTPN13; RAB14"
"R-HSA-6805567","Keratinization",-0.175716106628306,0.182593754863591,0.335882052883292,57,"CAPN1; CAPNS1; CASP14; CDSN; CELA2A; CSTA; DSC1; DSC2; DSC3; DSG1; DSG2; DSG3; DSP; EVPL; FLG; FURIN; IVL; JUP; KAZN; KLK12; KLK13; KLK14; KLK5; KLK8; KRT1; KRT10; KRT12; KRT13; KRT15; KRT16; KRT17; KRT18; KRT19; KRT2; KRT23; KRT24; KRT27; KRT3; KRT31; KRT32; KRT34; KRT36; KRT38; KRT39; KRT4; KRT40; KRT5; KRT6A; KRT6B; KRT6C; KRT7; KRT71; KRT72; KRT73; KRT74; KRT76; KRT77"
"R-HSA-194138","Signaling by VEGF",0.166079777151035,0.172779644334365,0.336440027790723,63,"ABI1; AHCYL1; AKT1; AKT2; AKT3; AXL; BAIAP2; BCAR1; BRK1; CALM1; CAV1; CDC42; CDH5; CRK; CTNNA1; CTNNB1; CTNND1; CYBA; CYFIP2; DOCK1; ELMO1; ELMO2; FLT4; FYN; HRAS; HSP90AA1; HSPB1; ITGAV; ITGB3; ITPR1; ITPR2; ITPR3; JUP; KDR; KRAS; MAPK11; MAPK12; MAPK13; MAPK14; MAPKAP1; MAPKAPK2; MAPKAPK3; MLST8; MTOR; NCF1; NCF2; NCF4; NCK1; NCK2; NCKAP1; NCKAP1L; NOS3; NRAS; NRP1; NRP2; PAK1; PAK2; PDPK1; PGF; PIK3CA; PIK3CB; PIK3R1; PIK3R2"
"R-HSA-5099900","WNT5A-dependent internalization of FZD4",0.337688043643899,0.351909665116252,0.337262965820547,14,"AP2A1; AP2A2; AP2B1; AP2M1; AP2S1; ARRB2; CLTA; CLTB; CLTC; DVL2; FZD4; PRKCA; PRKCB; WNT5A"
"R-HSA-69190","DNA strand elongation",-0.246652537605212,0.257155725455421,0.337480004789083,28,"CDC45; DNA2; GINS1; GINS2; GINS3; LIG1; MCM2; MCM3; MCM4; MCM5; MCM6; MCM7; MCM8; PCNA; POLA2; POLD1; POLD2; POLD3; PRIM1; PRIM2; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3"
"R-HSA-5654688","SHC-mediated cascade:FGFR1",0.316201311541108,0.331188480515444,0.33970549769402,16,"FGF1; FGF10; FGF17; FGF2; FGF20; FGF22; FGF5; FGF9; FGFR1; GRB2; HRAS; KL; KRAS; NRAS; SHC1; SOS1"
"R-HSA-539107","Activation of E2F1 target genes at G1/S",-0.249356599674165,0.261717707764045,0.340706967520564,27,"CCNA1; CCNE1; CDC25A; CDC45; CDC6; CDK1; CDT1; DHFR; E2F1; E2F4; E2F5; E2F6; FBXO5; HDAC1; LIN37; LIN52; LIN54; LIN9; ORC1; PCNA; RBBP4; RBL1; RBL2; RRM2; TFDP1; TK1; TYMS"
"R-HSA-69205","G1/S-Specific Transcription",-0.249356599674165,0.261717707764045,0.340706967520564,27,"CCNA1; CCNE1; CDC25A; CDC45; CDC6; CDK1; CDT1; DHFR; E2F1; E2F4; E2F5; E2F6; FBXO5; HDAC1; LIN37; LIN52; LIN54; LIN9; ORC1; PCNA; RBBP4; RBL1; RBL2; RRM2; TFDP1; TK1; TYMS"
"R-HSA-69206","G1/S Transition",0.164612805990202,0.172815029410807,0.340824428032083,63,"AKT1; AKT2; AKT3; CCNA1; CCNA2; CCNB1; CCND1; CCNE1; CCNE2; CCNH; CDC25A; CDC45; CDC6; CDC7; CDK1; CDK2; CDK4; CDK7; CDKN1B; CDT1; CUL1; DBF4; DHFR; E2F1; E2F4; E2F5; E2F6; FBXO5; HDAC1; LIN37; LIN52; LIN54; LIN9; MAX; MCM10; MCM2; MCM3; MCM4; MCM5; MCM6; MCM7; MCM8; MNAT1; MYC; ORC1; ORC3; ORC4; ORC5; ORC6; PCNA; POLA2; POLE; POLE2; POLE3; POLE4; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PRIM1; PRIM2; PSMA1; PSMA2"
"R-HSA-3214858","RMTs methylate histone arginines",-0.223225789437033,0.234435785972101,0.341004138988217,34,"ACTL6A; ARID1B; ARID2; CARM1; CCND1; CDK4; COPRS; DNMT3A; H2AFJ; H2AFV; H2AFX; H2AFZ; HIST1H2AG; HIST2H2AA3; HIST2H2AC; HIST3H2A; JAK2; PBRM1; PRMT1; PRMT5; PRMT6; PRMT7; RPS2; SMARCA2; SMARCA4; SMARCB1; SMARCC1; SMARCC2; SMARCD1; SMARCD2; SMARCD3; SMARCE1; WDR5; WDR77"
"R-HSA-5683057","MAPK family signaling cascades",0.170779293679252,0.179874589720448,0.342399239499769,58,"ACTN2; AGO1; AGO2; AGO3; AGO4; AKAP9; ANGPT1; APBB1IP; ARRB1; ARRB2; ARTN; BRAF; BRAP; BTC; CALM1; CAMK2A; CAMK2B; CAMK2D; CAMK2G; CCND3; CDC14A; CDC14B; CDC42; CDC42EP2; CDC42EP3; CDC42EP5; CDK1; CNKSR1; CSF2RB; CSK; CUL3; DAB2IP; DLG4; DNAJB1; DUSP1; DUSP10; DUSP16; DUSP2; DUSP4; DUSP5; DUSP7; DUSP8; EGF; EGFR; ERBB2; ERBB3; ERBB4; EREG; ETV4; FGA; FGB; FGF1; FGF10; FGF17; FGF18; FGF2; FGF20; FGF22"
"R-HSA-2022090","Assembly of collagen fibrils and other multimeric structures",-0.179518979784641,0.189206232896797,0.342722056868133,53,"BMP1; CD151; COL10A1; COL11A1; COL11A2; COL15A1; COL18A1; COL1A1; COL1A2; COL24A1; COL27A1; COL2A1; COL3A1; COL4A1; COL4A2; COL4A3; COL4A4; COL5A1; COL5A2; COL5A3; COL6A1; COL6A2; COL6A3; COL6A5; COL6A6; COL8A1; COL8A2; COL9A1; COL9A2; COL9A3; CTSB; CTSL; CTSS; CTSV; DST; ITGA6; ITGB4; LAMA3; LAMB3; LAMC2; LOX; LOXL1; LOXL2; LOXL3; LOXL4; MMP3; MMP7; MMP9; PCOLCE; PLEC; PXDN; TLL1; TLL2"
"R-HSA-176187","Activation of ATR in response to replication stress",0.21918087764612,0.232596597143351,0.346027836486713,34,"ATR; ATRIP; CDC25A; CDC45; CDC6; CDC7; CDK2; CHEK1; DBF4; HUS1; MCM10; MCM2; MCM3; MCM4; MCM5; MCM6; MCM7; MCM8; ORC1; ORC3; ORC4; ORC5; ORC6; RAD1; RAD17; RAD9A; RAD9B; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3"
"R-HSA-1483249","Inositol phosphate metabolism",-0.192910104120589,0.204874829568385,0.346397558247833,45,"CALM1; IMPA1; IMPA2; INPP1; INPP4A; INPP4B; INPP5A; INPP5B; INPP5D; INPP5J; INPPL1; IP6K1; IP6K2; IP6K3; IPMK; IPPK; ISYNA1; ITPK1; ITPKA; ITPKB; ITPKC; MINPP1; MIOX; MTMR7; MTMR9; NUDT3; NUDT4; PLCB1; PLCB2; PLCB3; PLCB4; PLCD1; PLCD3; PLCD4; PLCE1; PLCG1; PLCG2; PLCH1; PLCH2; PLCZ1; PLD4; PPIP5K1; PPIP5K2; PTEN; SYNJ1"
"R-HSA-5678895","Defective CFTR causes cystic fibrosis",0.180150917687843,0.191431976077217,0.346668913289421,51,"CFTR; DERL1; DERL2; DERL3; ERLEC1; ERLIN1; ERLIN2; OS9; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13; PSMD2; PSMD3; PSMD4; PSMD5; PSMD6; PSMD7; PSMD8; PSMD9; PSME2; PSME3; PSME4; PSMF1; RNF185; RNF5; SEL1L; SEM1; UBA52; UBC; VCP"
"R-HSA-72163","mRNA Splicing - Major Pathway",0.170397121870689,0.181439429003883,0.34765859652404,57,"ALYREF; AQR; BCAS2; BUD31; CASC3; CCAR1; CD2BP2; CDC40; CDC5L; CHERP; CLP1; CPSF1; CPSF2; CPSF3; CPSF4; CPSF7; CRNKL1; CSTF1; CSTF2T; CSTF3; CTNNBL1; CWC15; CWC22; CWC27; DDX23; DDX42; DDX46; DDX5; DHX15; DHX16; DHX38; DNAJC8; EFTUD2; EIF4A3; ELAVL2; FIP1L1; FUS; GCFC2; GTF2F1; GTF2F2; HNRNPA1; HNRNPA3; HNRNPF; HNRNPH1; HNRNPK; HNRNPL; HNRNPM; HNRNPR; HNRNPU; HNRNPUL1; HSPA8; ISY1; LSM2; LSM4; LSM5; LSM6; LSM7"
"R-HSA-72172","mRNA Splicing",0.170397121870689,0.181439429003883,0.34765859652404,57,"ALYREF; AQR; BCAS2; BUD31; CASC3; CCAR1; CD2BP2; CDC40; CDC5L; CHERP; CLP1; CPSF1; CPSF2; CPSF3; CPSF4; CPSF7; CRNKL1; CSTF1; CSTF2T; CSTF3; CTNNBL1; CWC15; CWC22; CWC27; DDX23; DDX42; DDX46; DDX5; DHX15; DHX16; DHX38; DNAJC8; EFTUD2; EIF4A3; ELAVL2; FIP1L1; FUS; GCFC2; GTF2F1; GTF2F2; HNRNPA1; HNRNPA3; HNRNPF; HNRNPH1; HNRNPK; HNRNPL; HNRNPM; HNRNPR; HNRNPU; HNRNPUL1; HSPA8; ISY1; LSM2; LSM4; LSM5; LSM6; LSM7"
"R-HSA-8864260","Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors",0.23172379857352,0.246938014420463,0.348044781984169,30,"ATAD2; CGA; CGB3; CITED2; CITED4; DEK; EGFR; EP300; ERBB2; ESR1; HSPD1; KCTD1; KCTD15; KDM5B; KIT; MYBL2; MYC; NOP2; NPM1; SUMO1; TFAP2A; TFAP2B; TFAP2C; TFAP2E; TGFA; UBE2I; VEGFA; WWOX; YEATS4; YY1"
"R-HSA-73894","DNA Repair",0.169723272747085,0.181457020857871,0.349615200258391,57,"ABL1; ACTL6A; ACTR5; ACTR8; ADPRHL2; ALKBH2; ALKBH3; ALKBH5; APBB1; APEX1; AQR; ASCC1; ASCC2; ASCC3; ATM; ATR; ATRIP; BABAM1; BAP1; BARD1; BAZ1B; BLM; BRCA1; BRCA2; BRIP1; CCNA1; CCNA2; CCNH; CDK2; CDK7; CHD1L; CHEK1; CHEK2; COPS2; COPS3; COPS6; COPS7A; COPS7B; COPS8; CUL4A; DCLRE1A; DCLRE1B; DCLRE1C; DDB1; DDB2; DNA2; DTL; ELL; EME1; EME2; EP300; ERCC3; ERCC4; ERCC5; ERCC6; ERCC8; EXO1"
"R-HSA-9013507","NOTCH3 Activation and Transmission of Signal to the Nucleus",-0.282293404668822,0.30183147579016,0.34965005888529,20,"ADAM10; APH1A; APH1B; DLL1; EGF; EGFR; JAG1; JAG2; MIB1; MIB2; NCSTN; NEURL1; NEURL1B; NOTCH3; PSEN1; PSEN2; TACC3; UBA52; UBC; WWP2"
"R-HSA-8875555","MET activates RAP1 and RAC1",-0.370657967967057,0.397078443842668,0.350581053248003,11,"CRK; CRKL; DOCK7; GAB1; GRB2; HGF; MET; RAC1; RAP1A; RAP1B; RAPGEF1"
"R-HSA-6782210","Gap-filling DNA repair synthesis and ligation in TC-NER",0.170622568207121,0.183029884258736,0.35122721860287,56,"AQR; CCNH; CDK7; CUL4A; DDB1; EP300; ERCC3; ERCC6; ERCC8; GTF2H1; GTF2H2; GTF2H3; GTF2H4; GTF2H5; HMGN1; ISY1; LIG1; LIG3; MNAT1; PCNA; POLD1; POLD2; POLD3; POLE; POLE2; POLE3; POLE4; POLK; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; PPIE; PRPF19; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3; TCEA1; UBA52; UBC; USP7; UVSSA; XAB2; XRCC1"
"R-HSA-1482839","Acyl chain remodelling of PE",-0.252789069855348,0.271753137666017,0.35225934857432,25,"ABHD4; HRASLS; HRASLS2; HRASLS5; LPCAT3; LPCAT4; MBOAT1; MBOAT2; PLA2G10; PLA2G12A; PLA2G16; PLA2G1B; PLA2G2A; PLA2G2D; PLA2G4A; PLA2G4B; PLA2G4C; PLA2G4D; PLA2G4E; PLA2G4F; PLA2G5; PLA2G6; PLA2R1; PLBD1; PNPLA8"
"R-HSA-114608","Platelet degranulation ",0.16578187580527,0.180002695079133,0.357052185760175,58,"A1BG; A2M; ABCC4; ACTN1; ACTN2; ACTN4; ALB; ANXA5; APLP2; APOA1; APOH; APP; BRPF3; CALM1; CALU; CAP1; CD109; CD36; CD63; CD9; CDC37L1; CFD; CFL1; CHID1; CLEC3B; CLU; CTSW; CYB5R1; ECM1; EGF; ENDOD1; F13A1; F5; FAM3C; FAM49B; FGA; FGB; FGG; FN1; GAS6; GTPBP2; HABP4; HGF; HRG; IGF1; IGF2; ISLR; ITGA2B; ITGB3; ITIH3; ITIH4; KNG1; LEFTY2; LGALS3BP; LHFPL2; MANF; MMRN1; NHLRC2"
"R-HSA-76005","Response to elevated platelet cytosolic Ca2+",0.16578187580527,0.180002695079133,0.357052185760175,58,"A1BG; A2M; ABCC4; ACTN1; ACTN2; ACTN4; ALB; ANXA5; APLP2; APOA1; APOH; APP; BRPF3; CALM1; CALU; CAP1; CD109; CD36; CD63; CD9; CDC37L1; CFD; CFL1; CHID1; CLEC3B; CLU; CTSW; CYB5R1; ECM1; EGF; ENDOD1; F13A1; F5; FAM3C; FAM49B; FGA; FGB; FGG; FN1; GAS6; GTPBP2; HABP4; HGF; HRG; IGF1; IGF2; ISLR; ITGA2B; ITGB3; ITIH3; ITIH4; KNG1; LEFTY2; LGALS3BP; LHFPL2; MANF; MMRN1; NHLRC2"
"R-HSA-8868773","rRNA processing in the nucleus and cytosol",0.161741896057644,0.175664901412877,0.357185608246751,61,"BMS1; BYSL; C1D; CSNK1D; CSNK1E; DCAF13; DDX21; DDX49; DHX37; DIEXF; DIMT1; DIS3; EBNA1BP2; EMG1; ERI1; EXOSC1; EXOSC10; EXOSC2; EXOSC3; EXOSC4; EXOSC5; EXOSC6; EXOSC7; EXOSC8; EXOSC9; FAU; FBL; FCF1; FTSJ3; GAR1; GNL3; HEATR1; IMP3; IMP4; KRR1; LTV1; MPHOSPH10; MPHOSPH6; NAT10; NCL; NHP2; NIP7; NOB1; NOC4L; NOL11; NOL6; NOL9; NOP10; NOP14; NOP2; NOP56; NOP58; PDCD11; PELP1; PES1; PNO1; PWP2; RBM28; RCL1; RIOK1; RIOK2"
"R-HSA-140534","Ligand-dependent caspase activation",0.314941477353526,0.342120140106147,0.357281169227813,15,"CASP8; CD14; CFLAR; FADD; FAS; FASLG; LY96; RIPK1; TICAM1; TICAM2; TLR4; TNFRSF10A; TNFRSF10B; TNFSF10; TRAF2"
"R-HSA-196849","Metabolism of water-soluble vitamins and cofactors",-0.157361061799672,0.171437163198703,0.358674612611388,65,"AASDHPPT; ABCC1; ABCD4; ACACB; ACP5; ALDH1L1; ALDH1L2; AMN; AOX1; BST1; BTD; CD320; CD38; COASY; CTRB1; CTRB2; CTRC; CUBN; CYB5A; CYB5R3; CYP8B1; DHFR; DHFR2; ENPP1; ENPP3; FASN; FLAD1; FOLR2; FPGS; GIF; GPHN; GSTO1; GSTO2; HLCS; LMBRD1; MCCC1; MCCC2; MMAA; MMAB; MMACHC; MMADHC; MOCOS; MOCS1; MOCS2; MTHFD1; MTHFD1L; MTHFD2; MTHFD2L; MTHFR; MTHFS; MTR; MTRR; MUT; NADK; NADK2; NADSYN1; NAMPT; NAPRT; NAXD; NAXE; NFS1; NMNAT1; NMNAT2; NMNAT3; NMRK1"
"R-HSA-190241","FGFR2 ligand binding and activation",0.323704904581577,0.353261361658586,0.359492470617896,14,"FGF1; FGF10; FGF17; FGF18; FGF2; FGF20; FGF22; FGF5; FGF7; FGF9; FGFBP1; FGFBP2; FGFBP3; FGFR2"
"R-HSA-432720","Lysosome Vesicle Biogenesis",0.219153421331117,0.239711384051849,0.360591439237842,32,"AP1B1; AP1G1; AP1G2; AP1M1; AP1M2; AP1S1; AP1S3; AP4B1; AP4E1; AP4M1; AP4S1; APP; ARRB1; BLOC1S1; CHMP2A; CLTA; CLTB; CLTC; CLVS1; CLVS2; CTSZ; DNAJC6; DNASE2; DNM2; GNS; HGS; HSPA8; M6PR; SH3GL2; TXNDC5; VAMP2; VAMP8"
"R-HSA-1638091","Heparan sulfate/heparin (HS-GAG) metabolism",-0.18505572584214,0.202854860202072,0.361633549196672,46,"AGRN; B3GALT6; B3GAT1; B3GAT2; B3GAT3; B4GALT7; BCAN; CSPG4; CSPG5; DCN; EXT1; EXT2; GLB1; GLB1L; GLCE; GPC1; GPC2; GPC5; GPC6; GUSB; HPSE; HPSE2; HS2ST1; HS3ST1; HS3ST2; HS3ST3A1; HS3ST3B1; HS3ST6; HS6ST1; HS6ST3; HSPG2; IDUA; NAGLU; NDST1; NDST2; NDST3; NDST4; SDC1; SDC2; SDC3; SDC4; SGSH; SLC35D2; VCAN; XYLT1; XYLT2"
"R-HSA-202131","Metabolism of nitric oxide",0.311735632161499,0.34240577223938,0.362597098890333,15,"AKT1; CALM1; CAV1; CYGB; DDAH1; DDAH2; DNM2; HSP90AA1; LYPLA1; NOS3; NOSIP; NOSTRIN; SPR; WASL; ZDHHC21"
"R-HSA-203765","eNOS activation and regulation",0.311735632161499,0.34240577223938,0.362597098890333,15,"AKT1; CALM1; CAV1; CYGB; DDAH1; DDAH2; DNM2; HSP90AA1; LYPLA1; NOS3; NOSIP; NOSTRIN; SPR; WASL; ZDHHC21"
"R-HSA-72312","rRNA processing",0.190572424139789,0.210462030776785,0.365202936876471,42,"BMS1; BYSL; C1D; CSNK1D; CSNK1E; DCAF13; DDX21; DDX49; DHX37; DIEXF; DIMT1; DIS3; EBNA1BP2; ELAC2; EMG1; ERI1; EXOSC1; EXOSC10; EXOSC2; EXOSC3; EXOSC4; EXOSC5; EXOSC6; EXOSC7; EXOSC8; EXOSC9; FAU; FBL; FCF1; FTSJ3; GAR1; GNL3; HEATR1; IMP3; IMP4; KIAA0391; KRR1; LTV1; MPHOSPH10; MPHOSPH6; MRM2; MRM3"
"R-HSA-1679131","Trafficking and processing of endosomal TLR",-0.359878827842352,0.398405437367919,0.3663677669435,11,"CNPY3; CTSB; CTSK; CTSL; CTSS; CTSV; HSP90B1; LGMN; TLR3; TLR9; UNC93B1"
"R-HSA-4086398","Ca2+ pathway",0.163782358250094,0.181609676173526,0.367143366002831,57,"AGO1; AGO2; AGO3; AGO4; AXIN2; CALM1; CAMK2A; CTNNB1; FZD2; FZD3; FZD4; FZD5; FZD6; GNAO1; GNAT2; GNB1; GNB2; GNB3; GNB4; GNB5; GNG10; GNG11; GNG12; GNG2; GNG3; GNG4; GNG5; GNG7; GNGT2; ITPR1; ITPR2; ITPR3; LEF1; MAP3K7; MOV10; MYC; NFATC1; PDE6A; PDE6B; PDE6G; PLCB1; PLCB2; PLCB3; PPP3CA; PPP3CB; PPP3R1; PRKCA; PRKG1; PRKG2; TCF7; TCF7L1; TCF7L2; TNRC6A; TNRC6B; TNRC6C; WNT11; WNT5A"
"R-HSA-983168","Antigen processing: Ubiquitination & Proteasome degradation",0.164726048244451,0.183183587944376,0.368524726311283,56,"ANAPC1; ANAPC10; ANAPC11; ANAPC13; ANAPC2; ANAPC4; ANAPC5; ANAPC7; AREL1; ARIH2; ASB1; ASB13; ASB14; ASB15; ASB16; ASB18; ASB2; ASB3; ASB4; ASB5; ASB6; ASB7; ASB8; ATG7; BLMH; BTBD1; BTBD6; BTRC; CBLB; CCNF; CDC16; CDC26; CDC27; CDC34; CUL1; CUL2; CUL3; CUL5; CUL7; DET1; DTX3L; DZIP3; ELOC; FBXL12; FBXL13; FBXL16; FBXL18; FBXL20; FBXL22; FBXL3; FBXL4; FBXL5; FBXL7; FBXL8; FBXO10; FBXO11"
"R-HSA-983169","Class I MHC mediated antigen processing & presentation",0.161799417124208,0.180102581213686,0.368986368095797,58,"ANAPC1; ANAPC10; ANAPC11; ANAPC13; ANAPC2; ANAPC4; ANAPC5; ANAPC7; AREL1; ARIH2; ASB1; ASB13; ASB14; ASB15; ASB16; ASB18; ASB2; ASB3; ASB4; ASB5; ASB6; ASB7; ASB8; ATG7; B2M; BLMH; BTBD1; BTBD6; BTRC; CALR; CANX; CBLB; CCNF; CD14; CD207; CD36; CDC16; CDC26; CDC27; CDC34; CHUK; CTSL; CTSS; CTSV; CUL1; CUL2; CUL3; CUL5; CUL7; CYBA; DET1; DTX3L; DZIP3; ELOC; ERAP1; ERAP2; FBXL12; FBXL13"
"R-HSA-74158","RNA Polymerase III Transcription",0.193581826459396,0.215516292244092,0.369066337689532,40,"BDP1; BRF1; BRF2; CRCP; GTF3A; GTF3C1; GTF3C2; GTF3C3; GTF3C4; GTF3C5; GTF3C6; NFIA; NFIB; NFIC; NFIX; POLR1C; POLR1D; POLR2E; POLR2F; POLR2H; POLR2K; POLR2L; POLR3A; POLR3B; POLR3C; POLR3D; POLR3F; POLR3G; POLR3GL; POLR3H; POLR3K; POU2F1; SNAPC1; SNAPC2; SNAPC3; SNAPC4; SNAPC5; SSB; TBP; ZNF143"
"R-HSA-749476","RNA Polymerase III Abortive And Retractive Initiation",0.193581826459396,0.215516292244092,0.369066337689532,40,"BDP1; BRF1; BRF2; CRCP; GTF3A; GTF3C1; GTF3C2; GTF3C3; GTF3C4; GTF3C5; GTF3C6; NFIA; NFIB; NFIC; NFIX; POLR1C; POLR1D; POLR2E; POLR2F; POLR2H; POLR2K; POLR2L; POLR3A; POLR3B; POLR3C; POLR3D; POLR3F; POLR3G; POLR3GL; POLR3H; POLR3K; POU2F1; SNAPC1; SNAPC2; SNAPC3; SNAPC4; SNAPC5; SSB; TBP; ZNF143"
"R-HSA-2559583","Cellular Senescence",0.160086242064805,0.178627250902978,0.370144461581838,59,"ACD; AGO1; AGO3; AGO4; ANAPC1; ANAPC10; ANAPC11; ANAPC15; ANAPC16; ANAPC2; ANAPC4; ANAPC5; ANAPC7; ASF1A; ATM; BMI1; CABIN1; CBX2; CBX4; CBX6; CBX8; CCNA1; CCNA2; CCNE1; CCNE2; CDC16; CDC26; CDC27; CDK2; CDK4; CDK6; CDKN1B; CDKN2A; CDKN2B; CDKN2C; CDKN2D; CEBPB; CXCL8; E2F1; E2F2; EED; EHMT1; EHMT2; EP400; ETS1; ETS2; EZH2; FOS; FZR1; H1F0; H2AFJ; H2AFV; H2AFX; H2AFZ; H2BFS; H3F3A; HIST1H1C; HIST1H1D; HIST1H1E"
"R-HSA-8851805","MET activates RAS signaling",0.353329320770085,0.395066935703291,0.371133021731396,11,"GRB2; HGF; HRAS; KRAS; MET; MUC20; NRAS; RANBP10; RANBP9; SHC1; SOS1"
"R-HSA-6814122","Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding",0.199731513413092,0.223794747705199,0.372137678377715,37,"CCT2; CCT3; CCT4; CCT5; CCT6A; CCT6B; CCT7; CCT8; CSNK2A2; CSNK2B; GNAI1; GNAI2; GNAI3; GNAO1; GNAT1; GNAT2; GNAT3; GNAZ; GNB1; GNB2; GNB3; GNB4; GNB5; GNG10; GNG11; GNG12; GNG2; GNG3; GNG4; GNG5; GNG7; GNGT2; RGS11; RGS6; RGS7; RGS9; TCP1"
"R-HSA-2029480","Fcgamma receptor (FCGR) dependent phagocytosis",0.216925817226607,0.24362376108871,0.373244047189259,31,"ABI1; ABL1; ACTG1; ACTR2; ACTR3; AHCYL1; ARPC1A; ARPC1B; ARPC2; ARPC3; ARPC4; ARPC5; BAIAP2; BRK1; CD247; CDC42; CFL1; CRK; CYFIP2; DOCK1; ELMO1; ELMO2; FCGR1A; FCGR2A; FCGR3A; FGR; FYN; GRB2; HCK; HSP90AA1; HSP90AB1"
"R-HSA-379716","Cytosolic tRNA aminoacylation",-0.246733215215252,0.277638985112755,0.374173142709695,24,"AARS; AIMP1; AIMP2; CARS; DARS; EEF1E1; EPRS; FARSA; FARSB; GARS; HARS; IARS; KARS; LARS; MARS; NARS; PPA1; QARS; RARS; SARS; TARS; VARS; WARS; YARS"
"R-HSA-5576893","Phase 2 - plateau phase",-0.251568672223223,0.283324962134325,0.374586117568966,23,"AKAP9; CACNA1C; CACNA1D; CACNA1S; CACNA2D1; CACNA2D2; CACNA2D3; CACNA2D4; CACNB1; CACNB2; CACNB3; CACNB4; CACNG1; CACNG3; CACNG4; CACNG5; CACNG6; CACNG8; KCNE1; KCNE2; KCNE3; KCNE4; KCNQ1"
"R-HSA-1358803","Downregulation of ERBB2:ERBB3 signaling",0.36522364932268,0.412820007129275,0.376316117754147,10,"AKT1; AKT2; AKT3; ERBB2; ERBB3; NRG1; RNF41; UBA52; UBC; USP8"
"R-HSA-418885","DCC mediated attractive signaling",0.313095376707134,0.354254656117259,0.37679639586977,14,"ABLIM1; ABLIM2; ABLIM3; CDC42; DCC; DOCK1; FYN; NCK1; NTN1; PTK2; RAC1; SRC; TRIO; WASL"
"R-HSA-933542","TRAF6 mediated NF-kB activation",-0.255766048743288,0.289428520469541,0.376861789939555,22,"AGER; APP; CHUK; DDX58; IFIH1; IKBKB; MAP3K1; MAVS; MYD88; NFKB1; NFKB2; NFKBIA; NFKBIB; NKIRAS1; RELA; RNF135; S100A12; S100B; SAA1; TRAF2; TRAF6; TRIM25"
"R-HSA-375165","NCAM signaling for neurite out-growth",0.164055600568988,0.186528985210778,0.37912047618604,54,"AGRN; ARTN; CACNA1C; CACNA1D; CACNA1G; CACNA1H; CACNA1I; CACNA1S; CACNB1; CACNB2; CACNB3; CACNB4; CNTN2; COL4A1; COL4A2; COL4A3; COL4A4; COL6A1; COL6A2; COL6A3; COL6A5; COL6A6; COL9A1; COL9A2; COL9A3; FGFR1; FYN; GDNF; GFRA1; GFRA2; GFRA4; GRB2; HRAS; KRAS; MAPK1; MAPK3; NCAM1; NRAS; NRTN; PRNP; PSPN; PTK2; PTPRA; RPS6KA5; SOS1; SPTA1; SPTB; SPTBN1; SPTBN2; SPTBN4; SPTBN5; SRC; ST8SIA2; ST8SIA4"
"R-HSA-1433617","Regulation of signaling by NODAL",0.363115298367988,0.413083257134216,0.379381436061794,10,"ACVR1B; ACVR1C; ACVR2A; ACVR2B; CER1; DAND5; LEFTY1; LEFTY2; NODAL; TDGF1"
"R-HSA-112315","Transmission across Chemical Synapses",-0.156769840179537,0.178373373146048,0.379463151822934,60,"ABAT; ACHE; ACTN2; ADCY1; ADCY2; ADCY3; ADCY4; ADCY5; ADCY6; ADCY7; ADCY9; AKAP9; ALDH2; ALDH5A1; AP2A1; AP2A2; AP2B1; AP2M1; AP2S1; APBA1; ARL6IP5; BCHE; BRAF; CACFD1; CACNA1A; CACNA1B; CACNA1E; CACNA2D1; CACNA2D2; CACNA2D3; CACNB1; CACNB2; CACNB3; CACNB4; CACNG3; CACNG4; CACNG8; CALM1; CAMK2A; CAMK2B; CAMK2D; CAMK2G; CAMK4; CAMKK1; CHRNA1; CHRNA2; CHRNA3; CHRNA4; CHRNA5; CHRNA6; CHRNA7; CHRNB2; CHRNB3; CHRNB4; CHRND; CHRNE; CHRNG; COMT; CPLX1; DLG1"
"R-HSA-450282","MAPK targets/ Nuclear events mediated by MAP kinases",0.236998110073182,0.270092456889333,0.38023124195272,25,"ATF1; ATF2; DUSP3; DUSP4; DUSP7; FOS; MAPK1; MAPK10; MAPK11; MAPK14; MAPK3; MAPK8; MAPK9; MAPKAPK2; MEF2A; MEF2C; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5D; RPS6KA1; RPS6KA2; RPS6KA5; VRK3"
"R-HSA-72086","mRNA Capping",0.228082894363338,0.260402233340928,0.381091543838963,27,"CCNH; CDK7; ERCC3; GTF2F1; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; GTF2H5; MNAT1; NCBP1; NCBP2; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; RNGTT; RNMT; SUPT5H"
"R-HSA-5620912","Anchoring of the basal body to the plasma membrane",0.152340304866997,0.174476947234529,0.382594572882805,62,"ACTR1A; AHI1; AKAP9; ALMS1; B9D1; B9D2; C2CD3; CC2D2A; CCP110; CDK1; CDK5RAP2; CENPJ; CEP131; CEP135; CEP152; CEP162; CEP164; CEP192; CEP250; CEP290; CEP41; CEP57; CEP63; CEP70; CEP72; CEP76; CEP78; CEP83; CEP89; CEP97; CKAP5; CLASP1; CNTRL; CSNK1D; CSNK1E; DCTN1; DCTN2; DYNC1H1; DYNC1I2; DYNLL1; FBF1; FGFR1OP; HAUS1; HAUS2; HAUS4; HAUS5; HAUS6; HAUS8; HSP90AA1; IQCB1; KIF24; MAPRE1; MKS1; NDE1; NEDD1; NEK2; NINL; NPHP1; NPHP4; ODF2; PAFAH1B1; PCM1"
"R-HSA-5654736","Signaling by FGFR1",0.187587652863579,0.215725196987734,0.384536722409378,40,"BRAF; CBL; FGF1; FGF10; FGF17; FGF18; FGF2; FGF20; FGF22; FGF5; FGF9; FGFR1; FGFRL1; FLRT1; FLRT2; FLRT3; FRS2; FRS3; GAB1; GRB2; HRAS; KL; KRAS; MAPK1; MAPK3; MKNK1; NRAS; PIK3CA; PIK3R1; PLCG1; PPP2CA; PPP2CB; PPP2R1A; SHC1; SOS1; SPRED1; SPRED2; SRC; UBA52; UBC"
"R-HSA-425397","Transport of vitamins, nucleosides, and related molecules",0.208664148440811,0.240165243207418,0.384936977800538,32,"ALB; APOD; LCN1; LCN12; LCN15; LCN9; SLC27A1; SLC27A4; SLC27A6; SLC28A2; SLC28A3; SLC29A1; SLC29A2; SLC29A3; SLC29A4; SLC33A1; SLC35A1; SLC35A3; SLC35B2; SLC35B3; SLC35B4; SLC35C1; SLC35D1; SLC35D2; SLC5A6; SLCO1B3; SLCO1C1; SLCO2A1; SLCO2B1; SLCO3A1; SLCO4A1; SLCO4C1"
"R-HSA-1362277","Transcription of E2F targets under negative control by DREAM complex",-0.283557443182051,0.327202578011096,0.386155033905986,17,"CDC25A; CDC6; E2F1; E2F4; E2F5; HDAC1; LIN37; LIN52; LIN54; LIN9; MAX; MYC; PCNA; RBBP4; RBL1; RBL2; TFDP1"
"R-HSA-450604","KSRP (KHSRP) binds and destabilizes mRNA",0.288103547216672,0.333535412971667,0.387704921335252,16,"AKT1; DCP2; DIS3; EXOSC1; EXOSC2; EXOSC3; EXOSC4; EXOSC5; EXOSC6; EXOSC7; EXOSC8; EXOSC9; MAPK11; MAPK14; PARN; YWHAZ"
"R-HSA-8934593","Regulation of RUNX1 Expression and Activity",0.295694747165128,0.343797708189221,0.389742998251079,15,"AGO1; AGO2; AGO3; AGO4; CBFB; CCND1; CCND2; CCND3; CDK6; MOV10; PML; SRC; TNRC6A; TNRC6B; TNRC6C"
"R-HSA-8956320","Nucleobase biosynthesis",0.303730721559786,0.355108062900858,0.392374496550318,14,"ADSL; ADSS; ADSSL1; ATIC; CAD; DHODH; GMPS; IMPDH1; IMPDH2; LHPP; PAICS; PFAS; PPAT; UMPS"
"R-HSA-189451","Heme biosynthesis",-0.356959514917086,0.418150623706249,0.393292006997375,10,"ALAD; ALAS1; COX10; COX15; CPOX; FECH; HMBS; PPOX; UROD; UROS"
"R-HSA-5357801","Programmed Cell Death",0.150646700452442,0.177370338762838,0.395695337855562,60,"ADD1; AKT1; AKT2; AKT3; APAF1; APC; APPL1; ARHGAP10; BAD; BAK1; BAX; BBC3; BCL2; BCL2L1; BCL2L11; BID; BIRC2; BIRC3; BMF; CASP3; CASP6; CASP7; CASP8; CASP9; CD14; CDH1; CFLAR; CTNNB1; CYCS; DAPK1; DAPK2; DAPK3; DBNL; DCC; DFFA; DFFB; DIABLO; DNM1L; DSG1; DSG2; DSG3; DSP; DYNLL1; DYNLL2; E2F1; FADD; FAS; FASLG; FNTA; GAS2; GSN; GZMB; H1F0; HIST1H1C; HIST1H1D; HIST1H1E; HMGB2; KPNA1; KPNB1; LMNA"
"R-HSA-2161522","Abacavir transport and metabolism",-0.354780661757035,0.418424014707539,0.39649507593327,10,"ABCB1; ABCG2; ADAL; ADH1A; GUK1; NT5C2; PCK1; SLC22A1; SLC22A2; SLC22A3"
"R-HSA-5358508","Mismatch Repair",-0.302944754627659,0.358817694108935,0.398509609058085,14,"EXO1; LIG1; MLH1; MSH2; MSH3; MSH6; PCNA; PMS2; POLD1; POLD2; POLD3; RPA1; RPA2; RPA3"
"R-HSA-6798695","Neutrophil degranulation",-0.147048827733797,0.174276612204721,0.398799704404726,63,"A1BG; ABCA13; ACAA1; ACLY; ACPP; ACTR10; ACTR1B; ACTR2; ADAM10; ADAM8; ADGRG3; AGA; AGL; AGPAT2; ALAD; ALDH3B1; ALDOC; ALOX5; AMPD3; ANO6; ANPEP; ANXA2; AOC1; AP1M1; AP2A2; APAF1; APEH; APRT; ARG1; ARHGAP9; ARL8A; ARMC8; ARPC5; ARSA; ARSB; ASAH1; ATAD3B; ATG7; ATP11A; ATP11B; ATP6V0A1; ATP6V0C; ATP6V1D; ATP8A1; ATP8B4; AZU1; B2M; B4GALT1; BIN2; BPI; BRI3; BST1; BST2; C16orf62; C3; C5AR1; C6orf120; CAB39; CALML5; CAMP; CAND1; CANT1; CAP1"
"R-HSA-9007101","Rab regulation of trafficking",0.148897251630081,0.177410412741202,0.401311443378849,60,"AKT1; AKT2; AKT3; ALS2; ALS2CL; ANKRD27; ARF6; CCZ1; CCZ1B; CHML; DENND1A; DENND1B; DENND1C; DENND2A; DENND2C; DENND2D; DENND3; DENND4A; DENND4B; DENND4C; DENND5A; DENND5B; DENND6A; DENND6B; GABARAP; GABARAPL2; GAPVD1; GDI2; GGA1; GGA2; GGA3; HPS1; HPS4; MADD; MAP1LC3B; MON1A; MON1B; OPTN; POLG; RAB10; RAB11A; RAB11B; RAB12; RAB13; RAB14; RAB18; RAB1A; RAB27A; RAB27B; RAB31; RAB32; RAB33B; RAB35; RAB38; RAB3A; RAB3GAP2; RAB3IL1; RAB3IP; RAB4A; RAB5A"
"R-HSA-629594","Highly calcium permeable postsynaptic nicotinic acetylcholine receptors",-0.351347164197559,0.418850774076824,0.401561270527938,10,"CHRNA1; CHRNA2; CHRNA3; CHRNA4; CHRNA5; CHRNA6; CHRNA7; CHRNB2; CHRNB3; CHRNB4"
"R-HSA-71182","Phenylalanine and tyrosine catabolism",0.332747874371488,0.397392956575363,0.402408755134243,11,"ASRGL1; FAH; GSTZ1; HGD; HPD; IL4I1; KYAT1; PAH; PCBD1; QDPR; TAT"
"R-HSA-5663220","RHO GTPases Activate Formins",-0.155038391263125,0.186256296626711,0.405187292028415,55,"ACTG1; AHCTF1; AURKB; B9D2; BIRC5; BUB1B; BUB3; CDC42; CENPA; CENPC; CENPE; CENPF; CENPH; CENPK; CENPL; CENPM; CENPN; CENPO; CENPP; CENPQ; CENPT; CENPU; CKAP5; CLASP1; CLIP1; DAAM1; DIAPH1; DIAPH3; DSN1; DVL1; DVL2; DVL3; DYNC1H1; DYNC1I1; DYNC1I2; DYNC1LI1; DYNC1LI2; DYNLL1; DYNLL2; EVL; FMNL1; FMNL2; FMNL3; INCENP; ITGB1; ITGB3BP; KIF2A; KIF2C; KNTC1; MAD1L1; MAD2L1; MAPRE1; MIS12; MKL1; NDE1"
"R-HSA-927802","Nonsense-Mediated Decay (NMD)",0.15527283723018,0.186753560563885,0.405729776478677,54,"CASC3; EIF4A3; EIF4G1; ETF1; FAU; GSPT1; MAGOH; MAGOHB; NCBP1; NCBP2; PABPC1; PNRC2; PPP2CA; PPP2R1A; PPP2R2A; RNPS1; RPL10A; RPL12; RPL13; RPL13A; RPL14; RPL15; RPL17; RPL18; RPL18A; RPL19; RPL21; RPL22L1; RPL23A; RPL26; RPL26L1; RPL27A; RPL28; RPL29; RPL3; RPL30; RPL31; RPL32; RPL34; RPL35; RPL35A; RPL36; RPL36AL; RPL37; RPL38; RPL39L; RPL3L; RPL4; RPL41; RPL5; RPL7; RPL7A; RPL8; RPL9"
"R-HSA-975957","Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)",0.15527283723018,0.186753560563885,0.405729776478677,54,"CASC3; EIF4A3; EIF4G1; ETF1; FAU; GSPT1; MAGOH; MAGOHB; NCBP1; NCBP2; PABPC1; PNRC2; PPP2CA; PPP2R1A; PPP2R2A; RNPS1; RPL10A; RPL12; RPL13; RPL13A; RPL14; RPL15; RPL17; RPL18; RPL18A; RPL19; RPL21; RPL22L1; RPL23A; RPL26; RPL26L1; RPL27A; RPL28; RPL29; RPL3; RPL30; RPL31; RPL32; RPL34; RPL35; RPL35A; RPL36; RPL36AL; RPL37; RPL38; RPL39L; RPL3L; RPL4; RPL41; RPL5; RPL7; RPL7A; RPL8; RPL9"
"R-HSA-1660661","Sphingolipid de novo biosynthesis",-0.176424517388213,0.212443596371593,0.406282456674658,42,"ACER2; ACER3; ALDH3A2; ALDH3B1; ALDH3B2; CERS1; CERS2; CERS3; CERS4; CERS5; CERS6; COL4A3BP; CSNK1G2; DEGS1; DEGS2; FA2H; KDSR; ORMDL1; ORMDL2; ORMDL3; PLPP1; PLPP2; PLPP3; PPM1L; PRKD1; PRKD2; PRKD3; SAMD8; SGMS1; SGMS2; SGPL1; SGPP1; SGPP2; SPHK1; SPHK2; SPTLC1; SPTLC2; SPTLC3; SPTSSA; SPTSSB; VAPA; VAPB"
"R-HSA-380108","Chemokine receptors bind chemokines",-0.185163206785547,0.223034024097517,0.406424802856032,38,"ACKR3; ACKR4; CCL13; CCL19; CCL20; CCL25; CCL27; CCL28; CCR1; CCR10; CCR2; CCR3; CCR5; CCR6; CCR7; CCRL2; CX3CL1; CX3CR1; CXCL1; CXCL10; CXCL11; CXCL12; CXCL13; CXCL16; CXCL2; CXCL3; CXCL6; CXCL8; CXCL9; CXCR1; CXCR2; CXCR4; CXCR5; CXCR6; PF4; XCL1; XCL2; XCR1"
"R-HSA-435354","Zinc transporters",0.294118615543062,0.355961106725325,0.408653127193204,14,"SLC30A1; SLC30A2; SLC30A5; SLC30A6; SLC30A8; SLC39A1; SLC39A10; SLC39A14; SLC39A2; SLC39A3; SLC39A4; SLC39A5; SLC39A6; SLC39A8"
"R-HSA-163359","Glucagon signaling in metabolic regulation",-0.217179471912735,0.263152122950602,0.409201238259467,27,"ADCY1; ADCY2; ADCY3; ADCY4; ADCY5; ADCY6; ADCY7; ADCY9; GCG; GNAS; GNB1; GNB2; GNB3; GNB4; GNG10; GNG11; GNG12; GNG2; GNG3; GNG4; GNG5; GNG7; PRKACB; PRKAR1A; PRKAR1B; PRKAR2A; PRKAR2B"
"R-HSA-5676594","TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway",-0.296190531670179,0.359395457895873,0.409862608468068,14,"BIRC2; BIRC3; CD40; LTA; LTBR; TNFRSF11A; TNFRSF12A; TNFRSF13C; TNFSF11; TNFSF12; TNFSF13B; TNFSF14; TRAF2; TRAF3"
"R-HSA-500792","GPCR ligand binding",-0.160461746562813,0.195176561682649,0.410999297804774,50,"ACKR1; ACKR3; ACKR4; ADCYAP1; ADCYAP1R1; ADGRE1; ADGRE2; ADM; ADM2; ADORA1; ADORA2A; ADORA2B; ADRA1A; ADRA1B; ADRA1D; ADRA2A; ADRA2C; ADRB1; ADRB2; AGT; AGTR1; ANXA1; APLNR; APP; AVPR1A; BDKRB1; BDKRB2; C3; C5; C5AR1; C5AR2; CALCA; CALCB; CALCRL; CASR; CCK; CCKAR; CCKBR; CCL13; CCL19; CCL20; CCL25; CCL27; CCL28; CCR1; CCR10; CCR2; CCR3; CCR5; CCR6"
"R-HSA-448424","Interleukin-17 signaling",0.153027245654234,0.18680938217525,0.412693691333541,54,"ATF1; ATF2; BTRC; CHUK; CUL1; DUSP3; DUSP4; DUSP7; FBXW11; FOS; IKBKB; IL17RA; IL17RB; IL17RC; IL17RE; IL25; IRAK2; MAP2K1; MAP2K3; MAP2K4; MAP2K6; MAP2K7; MAP3K7; MAP3K8; MAPK1; MAPK10; MAPK11; MAPK14; MAPK3; MAPK8; MAPK9; MAPKAPK2; MAPKAPK3; MEF2A; MEF2C; NFKB1; NOD1; NOD2; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5D; RIPK2; RPS6KA1; RPS6KA2; RPS6KA5; SKP1; TAB1; TAB2; TNIP2; TRAF6; UBA52; UBC"
"R-HSA-8852135","Protein ubiquitination",0.154308832317536,0.188514440301276,0.413042182992902,53,"BCL10; CDC34; CDC73; CTR9; DERL1; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HLA-A; HLA-B; HLTF; LEO1; OTULIN; PAF1; PCNA; PEX10; PEX12; PEX2; PEX5; PRKDC; RAD18; RNF144A; RNF152; RNF181; RNF20; RNF40; RRAGA; RTF1; SELENOS; SHPRH; TMEM129; UBA52; UBA6; UBC; UBE2D1; UBE2D3; UBE2E1; UBE2E3; UBE2G1; UBE2G2; UBE2H; UBE2J2; UBE2K; UBE2L3; UBE2N; UBE2Q2; UBE2R2; UBE2S; UBE2T; UBE2W; UBE2Z; UCHL3"
"R-HSA-8849932","Synaptic adhesion-like molecules",-0.254473052156401,0.311433988848218,0.413870659356522,19,"DLG1; DLG4; FLOT1; FLOT2; GRIA1; GRIA4; GRIN1; GRIN2A; GRIN2B; GRIN2C; GRIN2D; LRFN1; LRFN2; LRFN3; LRFN4; PTPRD; PTPRF; PTPRS; RTN3"
"R-HSA-3000480","Scavenging by Class A Receptors",0.25781322302543,0.316714396651841,0.415631015808644,18,"APOA1; APOB; CALR; COL1A1; COL1A2; COL3A1; COL4A1; COL4A2; COLEC11; COLEC12; FTH1; FTL; HSP90B1; MARCO; MASP1; MSR1; SCARA5; SCGB3A2"
"R-HSA-2299718","Condensation of Prophase Chromosomes",0.224380501799876,0.27631149983464,0.41675931116051,24,"CCNB1; CDK1; H2AFJ; H2AFV; H2AFX; H2AFZ; H2BFS; H3F3A; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HIST2H2AA3; HIST2H2AC; KMT5A; MCPH1; NCAPD3; NCAPG2; NCAPH2; PLK1; RB1; SET; SMC2; SMC4"
"R-HSA-399719","Trafficking of AMPA receptors",-0.221844290497807,0.273221613652035,0.416816119218547,25,"AP2A1; AP2A2; AP2B1; AP2M1; AP2S1; CACNG3; CACNG4; CACNG8; CAMK2A; CAMK2B; CAMK2D; CAMK2G; DLG1; DLG4; EPB41L1; GRIA1; GRIA2; GRIA4; GRIP1; MDM2; MYO6; NSF; PICK1; PRKCA; PRKCB"
"R-HSA-399721","Glutamate binding, activation of AMPA receptors and synaptic plasticity",-0.221844290497807,0.273221613652035,0.416816119218547,25,"AP2A1; AP2A2; AP2B1; AP2M1; AP2S1; CACNG3; CACNG4; CACNG8; CAMK2A; CAMK2B; CAMK2D; CAMK2G; DLG1; DLG4; EPB41L1; GRIA1; GRIA2; GRIA4; GRIP1; MDM2; MYO6; NSF; PICK1; PRKCA; PRKCB"
"R-HSA-418360","Platelet calcium homeostasis",-0.226013754103038,0.278639304211823,0.417288844624307,24,"ATP2A1; ATP2A2; ATP2A3; ATP2B1; ATP2B2; ATP2B4; CALM1; ITPR1; ITPR2; ITPR3; ORAI2; P2RX1; P2RX2; P2RX3; P2RX4; P2RX5; P2RX6; P2RX7; SLC8A1; SLC8A3; SRI; STIM1; TRPC3; TRPC6"
"R-HSA-111447","Activation of BAD and translocation to mitochondria ",0.279516562924213,0.345138149484996,0.418015678667459,15,"AKT1; AKT2; AKT3; BAD; BCL2; BID; PPP3CC; PPP3R1; SFN; YWHAB; YWHAE; YWHAG; YWHAH; YWHAQ; YWHAZ"
"R-HSA-1296346","Tandem pore domain potassium channels",-0.339763353457227,0.420254000983134,0.418819246008445,10,"KCNK1; KCNK10; KCNK13; KCNK17; KCNK2; KCNK3; KCNK4; KCNK6; KCNK7; KCNK9"
"R-HSA-5654727","Negative regulation of FGFR2 signaling",0.223184095130421,0.276374166988996,0.419353562848375,24,"BRAF; CBL; FGF1; FGF10; FGF17; FGF18; FGF2; FGF20; FGF22; FGF5; FGF7; FGF9; FGFR2; FRS2; GRB2; MAPK1; MAPK3; MKNK1; PPP2CA; PPP2CB; PPP2R1A; SRC; UBA52; UBC"
"R-HSA-5620920","Cargo trafficking to the periciliary membrane",-0.171492986836951,0.21256394561722,0.419791490400837,42,"ARF4; ARL13B; ARL3; ASAP1; BBIP1; BBS1; BBS10; BBS12; BBS2; BBS4; BBS5; BBS7; BBS9; CCT2; CCT3; CCT4; CCT5; CCT8; CNGA4; CYS1; EXOC1; EXOC2; EXOC3; EXOC4; EXOC5; EXOC6; EXOC7; GBF1; INPP5E; MCHR1; MKKS; NPHP3; PDE6D; PKD1; PKD2; RAB11A; RAB11FIP3; RAB3IP; RAB8A; TCP1; TTC8; UNC119B"
"R-HSA-450294","MAP kinase activation in TLR cascade",0.153062789018198,0.190332614035447,0.421289667707918,52,"ATF1; ATF2; BTRC; CHUK; CUL1; DUSP3; DUSP4; DUSP7; FBXW11; FOS; IKBKB; IRAK2; MAP2K1; MAP2K3; MAP2K4; MAP2K6; MAP2K7; MAP3K7; MAP3K8; MAPK1; MAPK10; MAPK11; MAPK14; MAPK3; MAPK8; MAPK9; MAPKAPK2; MAPKAPK3; MEF2A; MEF2C; NFKB1; NOD1; NOD2; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5D; RIPK2; RPS6KA1; RPS6KA2; RPS6KA5; SKP1; TAB1; TAB2; TNIP2; TRAF6; UBA52; UBC; UBE2N; UBE2V1; VRK3"
"R-HSA-8953854","Metabolism of RNA",-0.143609665827757,0.178590788798491,0.421323663154772,60,"ADAR; ADARB1; ADAT1; ADAT2; ADAT3; AKT1; ALKBH8; ALYREF; ANP32A; APOBEC2; APOBEC3A; APOBEC3B; APOBEC3C; APOBEC3H; AQR; BCAS2; BMS1; BUD31; BYSL; C14orf166; C1D; C2orf49; CASC3; CCAR1; CCNH; CD2BP2; CD44; CDC40; CDC5L; CDK7; CDKAL1; CHERP; CHTOP; CLNS1A; CLP1; CNOT1; CNOT11; CNOT2; CNOT3; CNOT4; CNOT6; CNOT6L; CNOT7; CNOT8; CPSF1; CPSF2; CPSF3; CPSF4; CPSF7; CRNKL1; CSNK1D; CSNK1E; CSTF1; CSTF2T; CSTF3; CTNNBL1; CTU1; CTU2; CWC15; CWC22"
"R-HSA-373076","Class A/1 (Rhodopsin-like receptors)",-0.15758139124499,0.19719976756967,0.424235202297557,49,"ACKR1; ACKR3; ACKR4; ADORA1; ADORA2A; ADORA2B; ADRA1A; ADRA1B; ADRA1D; ADRA2A; ADRA2C; ADRB1; ADRB2; AGT; AGTR1; ANXA1; APLNR; APP; AVPR1A; BDKRB1; BDKRB2; C3; C5; C5AR1; C5AR2; CCK; CCKAR; CCKBR; CCL13; CCL19; CCL20; CCL25; CCL27; CCL28; CCR1; CCR10; CCR2; CCR3; CCR5; CCR6; CCR7; CCRL2; CGA; CHRM2; CHRM3; CHRM4; CHRM5; CMKLR1; CNR1"
"R-HSA-8964038","LDL clearance",-0.248460379431709,0.311788497516315,0.425516328111458,19,"AP2A1; AP2A2; AP2B1; AP2M1; AP2S1; APOB; CES3; CLTA; CLTC; LDLR; LDLRAP1; LIPA; LSR; NCEH1; NPC1; NPC2; PCSK9; SOAT1; SOAT2"
"R-HSA-5250924","B-WICH complex positively regulates rRNA expression",0.169739918654347,0.213678604322813,0.426979939084606,41,"BAZ1B; DDX21; DEK; EP300; ERCC6; GSK3B; H2AFJ; H2AFV; H2AFX; H2AFZ; H2BFS; H3F3A; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HIST2H2AA3; HIST2H2AC; KAT2A; KAT2B; MYBBP1A; MYO1C; POLR1A; POLR1B; POLR1C; POLR1D; POLR1E; POLR2E; POLR2F; POLR2H; POLR2K; POLR2L; SF3B1; SMARCA5; TAF1A; TAF1B; TAF1C; TAF1D; TBP; TWISTNB; ZNRD1"
"R-HSA-375276","Peptide ligand-binding receptors",-0.15280780690583,0.193394492086331,0.429448780836866,51,"ACKR1; ACKR3; ACKR4; AGT; AGTR1; ANXA1; APLNR; APP; AVPR1A; BDKRB1; BDKRB2; C3; C5; C5AR1; C5AR2; CCK; CCKAR; CCKBR; CCL13; CCL19; CCL20; CCL25; CCL27; CCL28; CCR1; CCR10; CCR2; CCR3; CCR5; CCR6; CCR7; CCRL2; CORT; CX3CL1; CX3CR1; CXCL1; CXCL10; CXCL11; CXCL12; CXCL13; CXCL16; CXCL2; CXCL3; CXCL6; CXCL8; CXCL9; CXCR1; CXCR2; CXCR4; CXCR5; CXCR6"
"R-HSA-72706","GTP hydrolysis and joining of the 60S ribosomal subunit",-0.145415507381502,0.184767519464324,0.431270873779517,56,"EIF2S1; EIF2S2; EIF3A; EIF3B; EIF3C; EIF3D; EIF3E; EIF3F; EIF3G; EIF3H; EIF3I; EIF3J; EIF3K; EIF3L; EIF3M; EIF4A1; EIF4A2; EIF4B; EIF4E; EIF4G1; EIF4H; EIF5; EIF5B; FAU; RPL10A; RPL12; RPL13; RPL13A; RPL14; RPL15; RPL17; RPL18; RPL18A; RPL19; RPL21; RPL22L1; RPL23A; RPL26; RPL26L1; RPL27A; RPL28; RPL29; RPL3; RPL30; RPL31; RPL32; RPL34; RPL35; RPL35A; RPL36; RPL36AL; RPL37; RPL38; RPL39L; RPL3L; RPL4"
"R-HSA-418217","G beta:gamma signalling through PLC beta",0.25646731725393,0.325957631838033,0.431392033662477,17,"GNB1; GNB2; GNB3; GNB4; GNB5; GNG10; GNG11; GNG12; GNG2; GNG3; GNG4; GNG5; GNG7; GNGT2; PLCB1; PLCB2; PLCB3"
"R-HSA-2426168","Activation of gene expression by SREBF (SREBP)",0.178645032370006,0.227634916974585,0.432578183177268,36,"ACACB; CARM1; CHD9; CYP51A1; DHCR7; ELOVL6; FASN; FDFT1; FDPS; GGPS1; GPAM; HMGCR; HMGCS1; IDI1; LSS; MTF1; MVD; MVK; NCOA1; NCOA2; NCOA6; NFYA; NFYB; NFYC; PMVK; PPARA; RXRA; SC5D; SCD; SMARCD3; SP1; SQLE; SREBF1; SREBF2; TBL1XR1; TGS1"
"R-HSA-5693532","DNA Double-Strand Break Repair",0.150827995094177,0.192228435162043,0.432671151653039,51,"ABL1; APBB1; ATM; ATR; ATRIP; BABAM1; BAP1; BARD1; BAZ1B; BLM; BRCA1; BRCA2; BRIP1; CCNA1; CCNA2; CDK2; CHEK1; CHEK2; DCLRE1C; DNA2; EME1; EME2; ERCC4; EXO1; EYA1; EYA2; EYA3; EYA4; FAM175A; GEN1; H2AFX; H2BFS; HERC2; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HUS1; KAT5; KDM4A; KDM4B; KPNA2; LIG3; LIG4; MAPK8; MDC1; MRE11; MUS81; NBN; NHEJ1; PALB2"
"R-HSA-3781865","Diseases of glycosylation",-0.144707065795484,0.184779175952109,0.433547757861531,56,"ACAN; ADAMTS10; ADAMTS12; ADAMTS13; ADAMTS14; ADAMTS15; ADAMTS16; ADAMTS17; ADAMTS18; ADAMTS19; ADAMTS2; ADAMTS3; ADAMTS4; ADAMTS5; ADAMTS6; ADAMTS7; ADAMTS8; ADAMTS9; ADAMTSL1; ADAMTSL2; ADAMTSL3; ADAMTSL4; ADAMTSL5; AGRN; BCAN; CSPG4; CSPG5; DAG1; DCN; FMOD; GPC1; GPC2; GPC5; GPC6; HSPG2; KERA; LUM; MUC1; MUC12; MUC13; MUC15; MUC16; MUC20; MUC21; MUC3A; MUC4; MUC5B; MUC6; MUC7; MUCL1; NOTCH1; NOTCH2; NOTCH3; NOTCH4; OGN; OMD"
"R-HSA-380972","Energy dependent regulation of mTOR by LKB1-AMPK",-0.209914114072664,0.268436396833989,0.434221466131064,26,"CAB39; CAB39L; LAMTOR2; LAMTOR3; LAMTOR4; LAMTOR5; MLST8; MTOR; PPM1A; PRKAA1; PRKAA2; PRKAB1; PRKAB2; PRKAG1; PRKAG2; RHEB; RPTOR; RRAGA; RRAGC; RRAGD; SLC38A9; STK11; STRADA; STRADB; TSC1; TSC2"
"R-HSA-3928665","EPH-ephrin mediated repulsion of cells",0.159765225006748,0.204318144071538,0.434247835501516,45,"ADAM10; AP2A1; AP2A2; AP2B1; AP2M1; AP2S1; APH1A; APH1B; CLTA; CLTB; CLTC; CLTCL1; DNM1; EFNA1; EFNA2; EFNA5; EFNB2; EFNB3; EPHA1; EPHA10; EPHA2; EPHA3; EPHA4; EPHA5; EPHA6; EPHA7; EPHA8; EPHB1; EPHB2; EPHB3; EPHB4; EPHB6; FYN; LYN; MMP2; MMP9; NCSTN; PSEN1; PSEN2; RAC1; SRC; TIAM1; VAV2; VAV3; YES1"
"R-HSA-1483166","Synthesis of PA",-0.17891125973949,0.229282554952083,0.435208968928242,36,"ACP6; AGPAT1; AGPAT2; AGPAT3; AGPAT4; AGPAT5; DDHD1; DDHD2; GNPAT; GPAM; GPAT2; GPAT3; GPAT4; GPD1; GPD1L; GPD2; LCLAT1; LIPH; LIPI; LPCAT1; LPCAT4; MIGA1; MIGA2; PLA2G10; PLA2G12A; PLA2G1B; PLA2G2A; PLA2G2D; PLA2G4A; PLA2G4B; PLA2G4D; PLA2G5; PLA2R1; PLD1; PLD2; PLD6"
"R-HSA-3371511","HSF1 activation",0.22908249093131,0.295029212315281,0.437469209926039,21,"CRYBA4; DNAJB1; DNAJB6; FKBP4; HSBP1; HSF1; HSP90AA1; HSP90AB1; HSPA1B; HSPA1L; HSPA6; HSPH1; MRPL18; RLN1; RPA1; RPA2; RPA3; SERPINH1; TNFRSF21; VCP; YWHAE"
"R-HSA-202403","TCR signaling",0.141201151626548,0.182149663041532,0.438225598314782,57,"BCL10; BTRC; CARD11; CD101; CD247; CD3D; CD3E; CD4; CDC34; CHUK; CSK; CUL1; ENAH; EVL; FBXW11; FYB; GRAP2; HLA-DPA1; HLA-DPB1; HLA-DQA1; HLA-DQA2; HLA-DQB1; HLA-DQB2; HLA-DRA; HLA-DRB1; HLA-DRB5; IKBKB; INPP5D; ITK; LAT; LCP2; MALT1; MAP3K7; NCK1; NFKB1; NFKBIA; PAG1; PAK1; PAK2; PDPK1; PIK3CA; PIK3CB; PIK3R1; PIK3R2; PLCG1; PRKCQ; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5"
"R-HSA-68886","M Phase",-0.138418395795962,0.178669886712936,0.438507574346826,60,"ACTR1A; AHCTF1; AKAP9; ALMS1; ANAPC1; ANAPC10; ANAPC11; ANAPC15; ANAPC16; ANAPC2; ANAPC4; ANAPC5; ANAPC7; ANKLE2; ARPP19; AURKB; B9D2; BANF1; BIRC5; BLZF1; BUB1B; BUB3; CCNB1; CCNB2; CCP110; CDC16; CDC26; CDC27; CDCA5; CDK1; CDK5RAP2; CENPA; CENPC; CENPE; CENPF; CENPH; CENPJ; CENPK; CENPL; CENPM; CENPN; CENPO; CENPP; CENPQ; CENPT; CENPU; CEP131; CEP135; CEP152; CEP164; CEP192; CEP250; CEP290; CEP41; CEP57; CEP63; CEP70; CEP72; CEP76; CEP78"
"R-HSA-8983432","Interleukin-15 signaling",0.285529057577451,0.370126870373599,0.440448759399293,13,"GAB2; GRB2; IL15; IL15RA; IL2RB; JAK1; JAK3; SHC1; SOS1; SOS2; STAT3; STAT5A; STAT5B"
"R-HSA-109581","Apoptosis",0.135918498724989,0.17624797037913,0.440601629392479,61,"ADD1; AKT1; AKT2; AKT3; APAF1; APC; APPL1; ARHGAP10; BAD; BAK1; BAX; BBC3; BCL2; BCL2L1; BCL2L11; BID; BIRC2; BMF; CASP3; CASP6; CASP7; CASP8; CASP9; CD14; CDH1; CFLAR; CTNNB1; CYCS; DAPK1; DAPK2; DAPK3; DBNL; DCC; DFFA; DFFB; DIABLO; DNM1L; DSG1; DSG2; DSG3; DSP; DYNLL1; DYNLL2; E2F1; FADD; FAS; FASLG; FNTA; GAS2; GSN; GZMB; H1F0; HIST1H1C; HIST1H1D; HIST1H1E; HMGB2; KPNA1; KPNB1; LMNA; LMNB1; LY96"
"R-HSA-179409","APC-Cdc20 mediated degradation of Nek2A",0.232524908966516,0.30207655419137,0.4414452947912,20,"ANAPC1; ANAPC10; ANAPC11; ANAPC15; ANAPC16; ANAPC2; ANAPC4; ANAPC5; ANAPC7; BUB1B; BUB3; CDC16; CDC26; CDC27; MAD2L1; NEK2; UBA52; UBC; UBE2D1; UBE2E1"
"R-HSA-189200","Cellular hexose transport",-0.251839043998452,0.32934191198959,0.44446596921295,17,"MFSD4B; SLC2A1; SLC2A10; SLC2A11; SLC2A12; SLC2A4; SLC2A6; SLC2A7; SLC2A8; SLC2A9; SLC45A3; SLC50A1; SLC5A1; SLC5A10; SLC5A2; SLC5A4; SLC5A9"
"R-HSA-983189","Kinesins",0.17905994269903,0.234179583977767,0.44449391578123,34,"CENPE; KIF11; KIF12; KIF13B; KIF15; KIF16B; KIF18B; KIF19; KIF1A; KIF1B; KIF1C; KIF20A; KIF20B; KIF21A; KIF21B; KIF25; KIF26A; KIF26B; KIF27; KIF2A; KIF2C; KIF3A; KIF3C; KIF5A; KIF5B; KIF5C; KIF6; KIF9; KIFAP3; KIFC2; KLC1; KLC2; KLC4; RACGAP1"
"R-HSA-8936459","RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function",0.163314640435612,0.213876452763623,0.445109603978516,41,"AGO1; AGO3; AGO4; CBFB; DPY30; EP300; GP1BA; H2AFJ; H2AFV; H2AFX; H2AFZ; H2BFS; H3F3A; HDAC1; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HIST2H2AA3; HIST2H2AC; ITGA2B; KAT2B; KMT2A; KMT2C; KMT2E; MOV10; MYL9; NFE2; PF4; PRKCQ; PRMT1; PRMT6; RBBP5; SETD1A; SIN3B; THBS1; TNRC6A; TNRC6B; TNRC6C; WDR5; ZFPM1"
"R-HSA-3299685","Detoxification of Reactive Oxygen Species",-0.185383060899588,0.242914514455222,0.445366949617868,32,"AQP8; ATOX1; CAT; CCS; CYBA; CYCS; ERO1A; GPX1; GPX2; GPX3; GPX7; GPX8; GSR; GSTP1; NCF1; NCF2; NCF4; NOX4; NUDT2; P4HB; PRDX1; PRDX2; PRDX3; PRDX5; PRDX6; SOD1; SOD2; SOD3; TXN; TXN2; TXNRD1; TXNRD2"
"R-HSA-73777","RNA Polymerase I Chain Elongation",0.167054671875728,0.219138287794998,0.445865847904867,39,"CBX3; CCNH; CDK7; ERCC3; GTF2H1; GTF2H2; GTF2H3; GTF2H4; GTF2H5; H2AFJ; H2AFV; H2AFX; H2AFZ; H2BFS; H3F3A; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HIST2H2AA3; HIST2H2AC; MNAT1; POLR1A; POLR1B; POLR1C; POLR1D; POLR1E; POLR2E; POLR2F; POLR2H; POLR2K; POLR2L; TAF1A; TAF1B; TAF1C; TAF1D; TBP; TWISTNB; ZNRD1"
"R-HSA-350054","Notch-HLH transcription pathway",-0.304918190691524,0.40445225911428,0.45090684668179,11,"KAT2A; KAT2B; MAML1; MAML2; MAML3; NOTCH1; NOTCH2; NOTCH3; NOTCH4; RBPJ; SNW1"
"R-HSA-975138","TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation",0.136933195061469,0.182244515167851,0.452429570814222,57,"AGER; APP; ATF1; ATF2; BTRC; CD14; CHUK; CUL1; DUSP3; DUSP4; DUSP7; ECSIT; FBXW11; FOS; IKBKB; IRAK2; IRAK4; LY96; MAP2K1; MAP2K3; MAP2K4; MAP2K6; MAP2K7; MAP3K1; MAP3K7; MAP3K8; MAPK1; MAPK10; MAPK11; MAPK14; MAPK3; MAPK8; MAPK9; MAPKAPK2; MAPKAPK3; MEF2A; MEF2C; MYD88; NFKB1; NFKB2; NFKBIA; NFKBIB; NKIRAS1; NOD1; NOD2; PELI1; PELI2; PELI3; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5D; RELA; RIPK2; RPS6KA1; RPS6KA2"
"R-HSA-73614","Pyrimidine salvage",0.31459360981525,0.418783619784556,0.452527480103625,10,"CDA; DCK; TK1; TK2; TYMP; UCK1; UCK2; UCKL1; UPP1; UPP2"
"R-HSA-111885","Opioid Signalling",-0.133925193643421,0.178735311643414,0.453680370485379,60,"ADCY1; ADCY2; ADCY3; ADCY4; ADCY5; ADCY6; ADCY7; ADCY9; AHCYL1; CALM1; CAMK4; GNAI1; GNAI2; GNAI3; GNAL; GNAO1; GNAT1; GNAT2; GNAT3; GNAZ; GNB1; GNB2; GNB3; GNB4; GNB5; GNG10; GNG11; GNG12; GNG2; GNG3; GNG4; GNG5; GNG7; GNGT2; ITPR1; ITPR2; ITPR3; MAPK1; OPRM1; PDE1A; PDE1B; PDE1C; PDE4A; PDE4B; PDE4C; PDE4D; PDYN; PLA2G4A; PLCB1; PLCB2; PLCB3; PLCB4; POMC; PPP1R1B; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5D; PPP3CA"
"R-HSA-425366","Transport of bile salts and organic acids, metal ions and amine compounds",0.136188310129322,0.182260833553629,0.454932859297466,57,"BSG; CP; EMB; RHAG; RHBG; RHCG; SLC10A6; SLC11A1; SLC11A2; SLC13A2; SLC13A3; SLC13A4; SLC13A5; SLC14A1; SLC14A2; SLC16A1; SLC16A3; SLC16A7; SLC16A8; SLC18A1; SLC18A2; SLC22A1; SLC22A15; SLC22A16; SLC22A18; SLC22A2; SLC22A3; SLC22A4; SLC22A5; SLC22A7; SLC2A13; SLC30A1; SLC30A10; SLC30A2; SLC30A5; SLC30A6; SLC30A8; SLC31A1; SLC39A1; SLC39A10; SLC39A14; SLC39A2; SLC39A3; SLC39A4; SLC39A5; SLC39A6; SLC39A8; SLC40A1; SLC41A1; SLC41A2; SLC44A1; SLC44A2; SLC44A3; SLC44A4; SLC44A5; SLC47A1; SLC47A2"
"R-HSA-165159","mTOR signalling",0.170302352686516,0.227921226406988,0.454943870690446,36,"AKT1; AKT1S1; AKT2; CAB39; CAB39L; EEF2K; EIF4B; EIF4E; EIF4G1; LAMTOR2; LAMTOR3; LAMTOR4; LAMTOR5; MLST8; MTOR; PPM1A; PRKAA1; PRKAA2; PRKAB1; PRKAB2; PRKAG1; PRKAG2; RHEB; RPS6; RPS6KB1; RPTOR; RRAGA; RRAGC; RRAGD; SLC38A9; STK11; STRADA; STRADB; TSC1; TSC2; YWHAB"
"R-HSA-3322077","Glycogen synthesis",0.276806963950932,0.370890471150569,0.45546763963953,13,"EPM2A; GBE1; GYG1; GYS1; GYS2; NHLRC1; PGM1; PGM2; PGM2L1; PPP1R3C; UBA52; UBC; UGP2"
"R-HSA-373753","Nephrin family interactions",0.250130134660082,0.336410541354076,0.457163015609028,16,"ACTN1; ACTN2; ACTN4; CD2AP; FYN; IQGAP1; KIRREL2; KIRREL3; NCK1; NCK2; PIK3CA; PIK3CB; PIK3R1; PIK3R2; SPTBN1; WASL"
"R-HSA-6794361","Neurexins and neuroligins",-0.148263399743321,0.199406687204724,0.457165279607589,48,"APBA1; APBA2; APBA3; BEGAIN; DBNL; DLG2; DLG4; DLGAP1; DLGAP2; DLGAP3; DLGAP4; EPB41; EPB41L1; EPB41L2; EPB41L3; EPB41L5; GRIN1; GRIN2A; GRIN2B; GRIN2C; GRIN2D; GRM1; GRM5; HOMER1; HOMER2; HOMER3; LIN7A; LIN7B; LIN7C; LRRTM1; LRRTM3; LRRTM4; NLGN1; NRXN1; NRXN2; NRXN3; PDLIM5; SHANK1; SHANK2; SHANK3; SHARPIN; SIPA1L1; STX1A; STXBP1; SYT1; SYT10; SYT7; SYT9"
"R-HSA-194840","Rho GTPase cycle",-0.131776395332214,0.177308569008488,0.457358326731202,61,"A2M; ABR; AKAP13; ARAP1; ARAP2; ARAP3; ARHGAP1; ARHGAP10; ARHGAP11A; ARHGAP11B; ARHGAP12; ARHGAP15; ARHGAP17; ARHGAP18; ARHGAP19; ARHGAP20; ARHGAP21; ARHGAP22; ARHGAP24; ARHGAP25; ARHGAP26; ARHGAP27; ARHGAP28; ARHGAP29; ARHGAP30; ARHGAP31; ARHGAP32; ARHGAP33; ARHGAP35; ARHGAP39; ARHGAP40; ARHGAP42; ARHGAP44; ARHGAP5; ARHGAP8; ARHGAP9; ARHGDIA; ARHGDIB; ARHGDIG; ARHGEF10; ARHGEF10L; ARHGEF11; ARHGEF12; ARHGEF15; ARHGEF16; ARHGEF17; ARHGEF18; ARHGEF19; ARHGEF2; ARHGEF26; ARHGEF3; ARHGEF33; ARHGEF35; ARHGEF37; ARHGEF38; ARHGEF39; ARHGEF4; ARHGEF40; ARHGEF5; ARHGEF7; BCR"
"R-HSA-2979096","NOTCH2 Activation and Transmission of Signal to the Nucleus",-0.238433424277599,0.32088467496966,0.457451283936565,18,"ADAM10; APH1A; APH1B; CNTN1; DLL1; JAG1; JAG2; MDK; MIB1; MIB2; NCSTN; NEURL1; NEURL1B; NOTCH2; PSEN1; PSEN2; UBA52; UBC"
"R-HSA-73772","RNA Polymerase I Promoter Escape",0.194133865564502,0.261993126513227,0.458700478538311,27,"CCNH; CDK7; ERCC3; GTF2H1; GTF2H2; GTF2H3; GTF2H4; GTF2H5; MNAT1; POLR1A; POLR1B; POLR1C; POLR1D; POLR1E; POLR2E; POLR2F; POLR2H; POLR2K; POLR2L; RRN3; TAF1A; TAF1B; TAF1C; TAF1D; TBP; TWISTNB; ZNRD1"
"R-HSA-204998","Cell death signalling via NRAGE, NRIF and NADE",-0.136905929525821,0.184902702830347,0.45904430020739,56,"ABR; AKAP13; APH1A; APH1B; ARHGEF10; ARHGEF10L; ARHGEF11; ARHGEF12; ARHGEF15; ARHGEF16; ARHGEF17; ARHGEF18; ARHGEF19; ARHGEF2; ARHGEF26; ARHGEF3; ARHGEF33; ARHGEF35; ARHGEF37; ARHGEF38; ARHGEF39; ARHGEF4; ARHGEF40; ARHGEF5; ARHGEF7; BAD; BCL2L11; CASP3; ECT2; FGD2; FGD3; FGD4; GNA13; ITGB3BP; ITSN1; KALRN; MAPK8; MCF2L; NCSTN; NET1; NGEF; NGF; NGFR; OBSCN; PLEKHG2; PLEKHG5; PREX1; PSEN1; PSEN2; RAC1; RASGRF2; SOS1; SOS2; TIAM1; TIAM2; TRAF6"
"R-HSA-72202","Transport of Mature Transcript to Cytoplasm",-0.13310190245082,0.180240760067553,0.460230547887553,59,"ALYREF; CASC3; CDC40; CHTOP; CPSF1; CPSF2; CPSF3; CPSF4; DDX39A; DDX39B; DHX38; EIF4A3; EIF4E; FIP1L1; FYTTD1; GLE1; MAGOH; MAGOHB; NCBP1; NCBP2; NDC1; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188; NUP205; NUP210; NUP214; NUP35; NUP43; NUP50; NUP54; NUP58; NUP62; NUP85; NUP88; NUP93; NUP98; NUPL2; NXF1; NXT1; POLDIP3; POM121; RAE1; RANBP2; RNPS1; SARNP; SEH1L; SLBP; SLU7; SRRM1; SRSF11; SRSF4; SRSF5; SRSF6; SRSF7; SRSF9"
"R-HSA-1630316","Glycosaminoglycan metabolism",-0.128302968989893,0.174545632192903,0.462297871657643,63,"ABCC5; ACAN; AGRN; ARSB; B3GALT6; B3GAT1; B3GAT2; B3GAT3; B3GNT2; B3GNT3; B3GNT4; B3GNT7; B4GALT1; B4GALT2; B4GALT3; B4GALT4; B4GALT5; B4GALT6; B4GALT7; B4GAT1; BCAN; CD44; CEMIP; CHP1; CHPF; CHPF2; CHST1; CHST11; CHST12; CHST13; CHST15; CHST2; CHST3; CHST5; CHST6; CHST9; CHSY1; CHSY3; CSGALNACT1; CSGALNACT2; CSPG4; CSPG5; DCN; DSE; DSEL; EXT1; EXT2; FMOD; GLB1; GLB1L; GLCE; GNS; GPC1; GPC2; GPC5; GPC6; GUSB; HAS1; HAS2; HAS3; HEXA; HEXB; HMMR"
"R-HSA-8948216","Collagen chain trimerization",0.159125104990715,0.216642955893099,0.462641658865416,40,"COL10A1; COL11A1; COL11A2; COL12A1; COL13A1; COL14A1; COL15A1; COL16A1; COL17A1; COL18A1; COL19A1; COL1A1; COL1A2; COL20A1; COL21A1; COL22A1; COL23A1; COL24A1; COL25A1; COL27A1; COL28A1; COL2A1; COL3A1; COL4A1; COL4A2; COL4A3; COL4A4; COL5A1; COL5A2; COL5A3; COL6A1; COL6A2; COL6A3; COL6A5; COL6A6; COL8A1; COL8A2; COL9A1; COL9A2; COL9A3"
"R-HSA-432142","Platelet sensitization by LDL",0.254796699386886,0.347061895326796,0.46285520022035,15,"APOB; FGR; LRP8; MAPK14; PLA2G4A; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5A; PPP2R5B; PPP2R5C; PPP2R5D; PPP2R5E; PTPN6"
"R-HSA-1236977","Endosomal/Vacuolar pathway",0.293298349600187,0.401518070685677,0.465100745825396,11,"B2M; CTSL; CTSS; CTSV; HLA-A; HLA-B; HLA-C; HLA-E; HLA-F; HLA-G; LNPEP"
"R-HSA-6785631","ERBB2 Regulates Cell Motility",0.293264623344462,0.401521407366265,0.465155782158768,11,"BTC; DIAPH1; EGF; EGFR; ERBB2; ERBB3; ERBB4; EREG; MEMO1; NRG1; NRG4"
"R-HSA-913709","O-linked glycosylation of mucins",0.131893242686352,0.180789788985499,0.465671882425593,58,"A4GNT; B3GNT2; B3GNT3; B3GNT4; B3GNT5; B3GNT6; B3GNT7; B3GNT8; B3GNT9; B3GNTL1; B4GALT5; B4GALT6; C1GALT1; CHST4; GALNT1; GALNT10; GALNT11; GALNT12; GALNT13; GALNT14; GALNT15; GALNT16; GALNT18; GALNT2; GALNT3; GALNT4; GALNT5; GALNT6; GALNT7; GALNT8; GALNT9; GALNTL5; GALNTL6; GCNT1; GCNT3; GCNT4; GCNT7; MUC1; MUC12; MUC13; MUC15; MUC16; MUC20; MUC21; MUC3A; MUC4; MUC5B; MUC6; MUC7; MUCL1; ST3GAL1; ST3GAL3; ST3GAL4; ST6GAL1; ST6GALNAC2; ST6GALNAC3; ST6GALNAC4; WBSCR17"
"R-HSA-157579","Telomere Maintenance",-0.157155912619057,0.215453151497911,0.46574457498762,41,"ACD; DNA2; H2AFJ; H2AFV; H2AFX; H2AFZ; H2BFS; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HIST2H2AA3; HIST2H2AC; LIG1; NHP2; PCNA; POLA2; POLD1; POLD2; POLD3; POLE; POLE2; POLE3; POLE4; POT1; PRIM1; PRIM2; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3; RUVBL1; RUVBL2; TERF1; TERF2; TERF2IP; TERT"
"R-HSA-2467813","Separation of Sister Chromatids",-0.135696687075186,0.186578774084201,0.467048944888176,55,"AHCTF1; ANAPC1; ANAPC10; ANAPC11; ANAPC15; ANAPC16; ANAPC2; ANAPC4; ANAPC5; ANAPC7; AURKB; B9D2; BIRC5; BUB1B; BUB3; CDC16; CDC26; CDC27; CDCA5; CENPA; CENPC; CENPE; CENPF; CENPH; CENPK; CENPL; CENPM; CENPN; CENPO; CENPP; CENPQ; CENPT; CENPU; CKAP5; CLASP1; CLIP1; DSN1; DYNC1H1; DYNC1I1; DYNC1I2; DYNC1LI1; DYNC1LI2; DYNLL1; DYNLL2; ESPL1; INCENP; ITGB3BP; KIF2A; KIF2C; KNTC1; MAD1L1; MAD2L1; MAPRE1; MIS12; NDE1"
"R-HSA-1250196","SHC1 events in ERBB2 signaling",0.225241038593573,0.310356222290653,0.467992023525458,19,"BTC; EGF; EGFR; ERBB2; ERBB3; ERBB4; EREG; GRB2; HRAS; KRAS; NRAS; NRG1; NRG4; PRKCA; PRKCD; PRKCE; PTPN12; SHC1; SOS1"
"R-HSA-176407","Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase",0.244419937534835,0.336812971620316,0.468032233978006,16,"ANAPC1; ANAPC10; ANAPC11; ANAPC15; ANAPC16; ANAPC2; ANAPC4; ANAPC5; ANAPC7; CDC14A; CDC16; CDC26; CDC27; FZR1; UBE2D1; UBE2E1"
"R-HSA-5696394","DNA Damage Recognition in GG-NER",0.183048755965739,0.253298203705361,0.469888126325086,29,"ACTL6A; ACTR5; ACTR8; COPS2; COPS3; COPS6; COPS7A; COPS7B; COPS8; CUL4A; DDB1; DDB2; GPS1; INO80; INO80B; INO80C; INO80D; INO80E; MCRS1; NFRKB; PARP1; PARP2; RAD23B; RUVBL1; TFPT; UBA52; UBC; XPC; YY1"
"R-HSA-2559585","Oncogene Induced Senescence",0.189412853624436,0.262197381165012,0.470045151590861,27,"AGO1; AGO3; AGO4; CDK4; CDK6; CDKN2A; CDKN2B; CDKN2C; CDKN2D; E2F1; E2F2; ETS1; ETS2; ID1; MAPK1; MAPK3; MDM2; MDM4; MOV10; RB1; SP1; TFDP1; TNRC6A; TNRC6B; TNRC6C; UBA52; UBC"
"R-HSA-5633008","TP53 Regulates Transcription of Cell Death Genes",0.157899787855411,0.219422202293939,0.471761288675511,39,"AIFM2; APAF1; ATM; BAX; BBC3; BCL2L14; BID; BIRC5; BNIP3L; CASP1; CASP10; CASP6; CRADD; FAS; IGFBP3; NDRG1; NLRC4; PERP; PIDD1; PMAIP1; PPP1R13B; PRELID1; PRELID3A; RABGGTA; RABGGTB; STEAP3; TMEM219; TNFRSF10A; TNFRSF10B; TNFRSF10C; TNFRSF10D; TP53AIP1; TP53BP2; TP53I3; TP53INP1; TP63; TP73; TRIAP1; ZNF420"
"R-HSA-8847993","ERBB2 Activates PTK6 Signaling",0.301393928023022,0.4202136859393,0.473226221719952,10,"BTC; EGF; EGFR; ERBB2; ERBB3; ERBB4; EREG; NRG1; NRG4; PTK6"
"R-HSA-3772470","Negative regulation of TCF-dependent signaling by WNT ligand antagonists",0.266107486877763,0.371799571300045,0.474159113191828,13,"DKK1; DKK4; KREMEN1; KREMEN2; LRP5; LRP6; SFRP1; SFRP2; SOST; WIF1; WNT4; WNT5A; WNT9A"
"R-HSA-159236","Transport of Mature mRNA derived from an Intron-Containing Transcript",-0.13220672095625,0.184972844824679,0.474772289432294,56,"ALYREF; CASC3; CDC40; CHTOP; DDX39A; DDX39B; DHX38; EIF4A3; FYTTD1; GLE1; MAGOH; MAGOHB; NCBP1; NCBP2; NDC1; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188; NUP205; NUP210; NUP214; NUP35; NUP43; NUP50; NUP54; NUP58; NUP62; NUP85; NUP88; NUP93; NUP98; NUPL2; NXF1; NXT1; POLDIP3; POM121; RAE1; RANBP2; RNPS1; SARNP; SEH1L; SLU7; SRRM1; SRSF11; SRSF4; SRSF5; SRSF6; SRSF7; SRSF9; THOC1; THOC3; THOC5; THOC7"
"R-HSA-2672351","Stimuli-sensing channels",-0.131046883239797,0.183375036098024,0.474832372678895,57,"ANO1; ANO10; ANO2; ANO3; ANO4; ANO5; ANO6; ANO7; ANO8; ANO9; ASIC1; ASIC2; ASIC3; ASIC4; ASPH; BEST1; BEST3; BEST4; BSND; CALM1; CLCA2; CLCA4; CLCN1; CLCN2; CLCN3; CLCN6; CLCN7; CLCNKA; CLCNKB; FKBP1B; MCOLN2; MCOLN3; NALCN; NEDD4L; OSTM1; RAF1; RYR1; RYR2; RYR3; SCNN1A; SCNN1B; SCNN1D; SCNN1G; SGK1; SGK2; SGK3; SLC17A3; SLC9B1; SLC9B2; SLC9C1; SLC9C2; SRI; STOM; STOML3; TPCN2; TRDN; TRPC1"
"R-HSA-6803529","FGFR2 alternative splicing",0.198294069582826,0.277613854739969,0.475053955662329,24,"ESRP1; ESRP2; GTF2F1; GTF2F2; HNRNPA1; HNRNPF; HNRNPH1; HNRNPM; NCBP1; NCBP2; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; PTBP1; RBFOX2; TIAL1"
"R-HSA-68884","Mitotic Telophase/Cytokinesis",-0.30239291825061,0.42439922520018,0.47614285695805,10,"KIF20A; MAU2; NUDC; PDS5A; PDS5B; PLK1; RAD21; SMC3; STAG1; WAPL"
"R-HSA-3214841","PKMTs methylate histone lysines",0.166531576388688,0.234619465154964,0.47783165842418,34,"AEBP2; ATF7IP; DOT1L; DPY30; EED; EHMT1; EHMT2; EZH2; KMT2A; KMT2C; KMT2E; KMT5A; KMT5B; KMT5C; MECOM; NFKB1; NFKB2; NSD1; PRDM16; RBBP4; RBBP5; RELA; SETD1A; SETD2; SETD3; SETD6; SETD7; SETDB1; SETDB2; SMYD2; SMYD3; SUV39H2; SUZ12; WDR5"
"R-HSA-1482788","Acyl chain remodelling of PC",-0.198568613086541,0.279802717594333,0.477906542153892,24,"LPCAT1; LPCAT2; LPCAT3; LPCAT4; MBOAT2; PLA2G10; PLA2G12A; PLA2G16; PLA2G1B; PLA2G2A; PLA2G2D; PLA2G4A; PLA2G4B; PLA2G4C; PLA2G4D; PLA2G4E; PLA2G4F; PLA2G5; PLA2G6; PLA2R1; PLB1; PLBD1; PNPLA8; TMEM86B"
"R-HSA-3858494","Beta-catenin independent WNT signaling",0.123032077120971,0.173712119528368,0.47878834667952,63,"AGO1; AGO2; AGO3; AGO4; AP2A1; AP2A2; AP2B1; AP2M1; AP2S1; ARRB2; AXIN2; CALM1; CAMK2A; CLTA; CLTB; CLTC; CTNNB1; DAAM1; DVL1; DVL2; DVL3; FZD1; FZD2; FZD3; FZD4; FZD5; FZD6; FZD7; FZD8; GNAO1; GNAT2; GNB1; GNB2; GNB3; GNB4; GNB5; GNG10; GNG11; GNG12; GNG2; GNG3; GNG4; GNG5; GNG7; GNGT2; ITPR1; ITPR2; ITPR3; LEF1; MAP3K7; MOV10; MYC; NFATC1; PARD6A; PDE6A; PDE6B; PDE6G; PFN1; PLCB1; PLCB2; PLCB3; PPP3CA; PPP3CB"
"R-HSA-977444","GABA B receptor activation",-0.164280161164349,0.232904041974264,0.480588991899383,35,"ADCY1; ADCY2; ADCY3; ADCY4; ADCY5; ADCY6; ADCY7; ADCY9; GABBR1; GABBR2; GNAI1; GNAI2; GNAI3; GNAL; GNAT3; GNB1; GNB2; GNB3; GNG10; GNG12; GNG2; GNG3; GNG4; GNG5; GNG7; GNGT2; KCNJ10; KCNJ12; KCNJ15; KCNJ16; KCNJ2; KCNJ3; KCNJ4; KCNJ5; KCNJ6"
"R-HSA-991365","Activation of GABAB receptors",-0.164280161164349,0.232904041974264,0.480588991899383,35,"ADCY1; ADCY2; ADCY3; ADCY4; ADCY5; ADCY6; ADCY7; ADCY9; GABBR1; GABBR2; GNAI1; GNAI2; GNAI3; GNAL; GNAT3; GNB1; GNB2; GNB3; GNG10; GNG12; GNG2; GNG3; GNG4; GNG5; GNG7; GNGT2; KCNJ10; KCNJ12; KCNJ15; KCNJ16; KCNJ2; KCNJ3; KCNJ4; KCNJ5; KCNJ6"
"R-HSA-156580","Phase II - Conjugation of compounds",-0.124863339704248,0.177400766928838,0.481526859449801,61,"ABHD10; ABHD14B; ACSM1; ACSM4; ACSM5; AHCY; AKR1A1; AS3MT; BPNT1; CHAC1; CHAC2; CNDP2; COMT; CYP1A2; ESD; GCLC; GCLM; GGCT; GGT1; GGT5; GGT6; GGT7; GLYAT; GLYATL1; GLYATL2; GSS; GSTA1; GSTA2; GSTA3; GSTA4; GSTK1; GSTM1; GSTM2; GSTM3; GSTM4; GSTM5; GSTO1; GSTO2; GSTP1; GSTT2B; GSTZ1; HPGDS; IMPAD1; MAT1A; MAT2A; MAT2B; MGST1; MGST2; MGST3; MTR; MTRR; N6AMT1; NAT1; NAT2; NNMT; OPLAH; PAPSS1; PAPSS2; PODXL2; SLC26A1; SLC26A2"
"R-HSA-68877","Mitotic Prometaphase",-0.126824036932298,0.180327596255988,0.481870059797012,59,"ACTR1A; AHCTF1; AKAP9; ALMS1; AURKB; B9D2; BIRC5; BUB1B; BUB3; CCNB1; CCNB2; CCP110; CDCA5; CDK1; CDK5RAP2; CENPA; CENPC; CENPE; CENPF; CENPH; CENPJ; CENPK; CENPL; CENPM; CENPN; CENPO; CENPP; CENPQ; CENPT; CENPU; CEP131; CEP135; CEP152; CEP164; CEP192; CEP250; CEP290; CEP41; CEP57; CEP63; CEP70; CEP72; CEP76; CEP78; CKAP5; CLASP1; CLIP1; CNTRL; CSNK1D; CSNK1E; CSNK2A2; CSNK2B; DCTN1; DCTN2; DSN1; DYNC1H1; DYNC1I1; DYNC1I2; DYNC1LI1"
"R-HSA-3928663","EPHA-mediated growth cone collapse",0.252140842301818,0.359411035765966,0.482966733062558,14,"FYN; LYN; MYH10; MYH11; MYH14; MYH9; MYL12B; MYL6; MYL9; NGEF; ROCK1; ROCK2; SRC; YES1"
"R-HSA-556833","Metabolism of lipids",0.126624913155021,0.180899262237199,0.483943082746397,58,"AACS; ABCA1; ABCB4; ABCC1; ABCC3; ABHD3; ABHD4; ACAA1; ACAA2; ACACB; ACAD10; ACAD11; ACADL; ACADM; ACADS; ACADVL; ACAT1; ACAT2; ACBD4; ACBD5; ACBD7; ACER2; ACER3; ACHE; ACLY; ACOT1; ACOT11; ACOT12; ACOT13; ACOT2; ACOT4; ACOT6; ACOT7; ACOT8; ACOX1; ACOX2; ACOX3; ACP6; ACSBG1; ACSBG2; ACSF2; ACSF3; ACSL1; ACSL3; ACSL5; ACSL6; ACSM3; ACSM6; ACSS3; AGK; AGMO; AGPAT1; AGPAT2; AGPAT3; AGPAT4; AGPAT5; AGPS; AGT"
"R-HSA-8943723","Regulation of PTEN mRNA translation",-0.284216126056024,0.406421794602187,0.484356319037079,11,"AGO1; AGO2; AGO3; AGO4; CNOT6L; MOV10; PTEN; TNRC6A; TNRC6B; TNRC6C; VAPA"
"R-HSA-2990846","SUMOylation",-0.124893497763803,0.178858315313498,0.485001008938922,60,"AURKA; AURKB; BIRC5; BLM; BMI1; BRCA1; CBX2; CBX4; CBX5; CBX8; CDKN2A; CHD3; EID3; FOXL2; HDAC1; HDAC2; HDAC4; HDAC7; HERC2; HIC1; HNRNPK; INCENP; L3MBTL2; MDC1; MDM2; MITF; NDC1; NOP58; NSMCE1; NSMCE2; NSMCE3; NSMCE4A; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188; NUP205; NUP210; NUP214; NUP35; NUP43; NUP50; NUP54; NUP58; NUP62; NUP85; NUP88; NUP93; NUP98; NUPL2; PARP1; PCNA; PHC1; PHC2; PHC3; PIAS1; PIAS2; PIAS3"
"R-HSA-3108232","SUMO E3 ligases SUMOylate target proteins",-0.124893497763803,0.178858315313498,0.485001008938922,60,"AURKA; AURKB; BIRC5; BLM; BMI1; BRCA1; CBX2; CBX4; CBX5; CBX8; CDKN2A; CHD3; EID3; FOXL2; HDAC1; HDAC2; HDAC4; HDAC7; HERC2; HIC1; HNRNPK; INCENP; L3MBTL2; MDC1; MDM2; MITF; NDC1; NOP58; NSMCE1; NSMCE2; NSMCE3; NSMCE4A; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188; NUP205; NUP210; NUP214; NUP35; NUP43; NUP50; NUP54; NUP58; NUP62; NUP85; NUP88; NUP93; NUP98; NUPL2; PARP1; PCNA; PHC1; PHC2; PHC3; PIAS1; PIAS2; PIAS3"
"R-HSA-1445148","Translocation of GLUT4 to the plasma membrane",-0.132373167460701,0.190084652382483,0.486184240518519,53,"AKT1; AKT2; ASPSCR1; C2CD5; CALM1; EXOC1; EXOC2; EXOC3; EXOC4; EXOC5; EXOC6; EXOC7; KIF3A; KIFAP3; LNPEP; MYH13; MYH15; MYH3; MYH6; MYH7; MYH7B; MYO1C; MYO5A; PRKAA2; PRKAB1; PRKAB2; PRKAG1; PRKAG2; RAB10; RAB11A; RAB13; RAB14; RAB4A; RAB8A; RAC1; RALA; RALGAPA2; RALGAPB; RHOQ; SFN; SLC2A4; SNAP23; STX4; STXBP3; TBC1D1; TBC1D4; VAMP2; YWHAB; YWHAE; YWHAG; YWHAH; YWHAQ; YWHAZ"
"R-HSA-196741","Cobalamin (Cbl, vitamin B12) transport and metabolism",-0.21774423747008,0.313407771677489,0.48720361165191,19,"ABCC1; ABCD4; AMN; CD320; CTRB1; CTRB2; CTRC; CUBN; GIF; LMBRD1; MMAA; MMAB; MMACHC; MMADHC; MTR; MTRR; MUT; PRSS3; TCN2"
"R-HSA-389359","CD28 dependent Vav1 pathway",-0.29528546143376,0.425122227445403,0.487312555962424,10,"CD28; CD80; CD86; CDC42; FYN; GRB2; PAK1; PAK2; RAC1; VAV1"
"R-HSA-166166","MyD88-independent TLR4 cascade ",0.127659862205284,0.184048998437294,0.487921243449779,56,"AGER; APP; ATF1; ATF2; BIRC2; BIRC3; BTRC; CASP8; CD14; CHUK; CUL1; DUSP3; DUSP4; DUSP7; FADD; FBXW11; FOS; IKBKB; IRAK2; IRF3; IRF7; LY96; MAP2K1; MAP2K3; MAP2K4; MAP2K6; MAP2K7; MAP3K7; MAP3K8; MAPK1; MAPK10; MAPK11; MAPK14; MAPK3; MAPK8; MAPK9; MAPKAPK2; MAPKAPK3; MEF2A; MEF2C; MYD88; NFKB1; NFKB2; NFKBIA; NFKBIB; NKIRAS1; NOD1; NOD2; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5D; RELA; RIPK1; RIPK2"
"R-HSA-937061","TRIF(TICAM1)-mediated TLR4 signaling ",0.127659862205284,0.184048998437294,0.487921243449779,56,"AGER; APP; ATF1; ATF2; BIRC2; BIRC3; BTRC; CASP8; CD14; CHUK; CUL1; DUSP3; DUSP4; DUSP7; FADD; FBXW11; FOS; IKBKB; IRAK2; IRF3; IRF7; LY96; MAP2K1; MAP2K3; MAP2K4; MAP2K6; MAP2K7; MAP3K7; MAP3K8; MAPK1; MAPK10; MAPK11; MAPK14; MAPK3; MAPK8; MAPK9; MAPKAPK2; MAPKAPK3; MEF2A; MEF2C; MYD88; NFKB1; NFKB2; NFKBIA; NFKBIB; NKIRAS1; NOD1; NOD2; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5D; RELA; RIPK1; RIPK2"
"R-HSA-5663205","Infectious disease",0.123173990953457,0.177956346672075,0.488837822056032,60,"ANTXR1; ANTXR2; AP1B1; AP1G1; AP1M1; AP1M2; AP1S1; AP1S3; AP2A1; AP2A2; AP2B1; AP2M1; AP2S1; APOBEC3G; ATP6V1H; B2M; BANF1; BTRC; CALM1; CALR; CANX; CBL; CBLL1; CCNH; CCNK; CCNT1; CCNT2; CCR5; CD247; CD28; CD4; CD8B; CD9; CDH1; CDK7; CDK9; CHMP2A; CHMP2B; CHMP3; CHMP4A; CHMP4B; CHMP4C; CHMP5; CHMP6; CHMP7; CLTA; CLTC; CPSF4; CTDP1; CTNNB1; CTNND1; CUL5; CXCR4; DNAJC3; DOCK2; EEF2; EIF2AK2; ELL; ELMO1; ELOA"
"R-HSA-196854","Metabolism of vitamins and cofactors",0.123983923340969,0.180952825293734,0.493234992472286,58,"AASDHPPT; ABCC1; ABCD4; ACACB; ACP5; AGRN; AKR1B10; AKR1C1; AKR1C3; AKT1; ALDH1L1; ALDH1L2; AMN; AOX1; APOA1; APOA2; APOB; APOC3; APOM; BCO1; BCO2; BST1; BTD; CALM1; CD320; CD38; CLPS; COASY; COQ2; COQ3; COQ5; COQ6; COQ7; COQ9; CTRB1; CTRB2; CTRC; CUBN; CYB5A; CYB5R3; CYP8B1; DHFR; DHFR2; ENPP1; ENPP3; FASN; FLAD1; FOLR2; FPGS; GCH1; GIF; GPC1; GPC2; GPC5; GPC6; GPHN; GSTO1; GSTO2"
"R-HSA-381771","Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)",-0.226412326842979,0.330838591977821,0.493748577663721,17,"CDX2; CTNNB1; DPP4; FFAR1; FFAR4; GCG; GNAT3; GNB3; GRP; PAX6; PCSK1; SEC11A; SEC11C; SPCS1; SPCS2; SPCS3; TCF7L2"
"R-HSA-400508","Incretin synthesis, secretion, and inactivation",-0.226412326842979,0.330838591977821,0.493748577663721,17,"CDX2; CTNNB1; DPP4; FFAR1; FFAR4; GCG; GNAT3; GNB3; GRP; PAX6; PCSK1; SEC11A; SEC11C; SPCS1; SPCS2; SPCS3; TCF7L2"
"R-HSA-159418","Recycling of bile acids and salts",-0.266921144958631,0.390616263032841,0.494396184083378,12,"ABCC3; ALB; BAAT; FABP6; NCOA1; NCOA2; NR1H4; RXRA; SLC10A1; SLC27A5; SLCO1B3; STARD5"
"R-HSA-140342","Apoptosis induced DNA fragmentation",0.287886655436509,0.421622770741166,0.494729291170585,10,"CASP3; DFFA; DFFB; H1F0; HIST1H1C; HIST1H1D; HIST1H1E; HMGB2; KPNA1; KPNB1"
"R-HSA-211227","Activation of DNA fragmentation factor",0.287886655436509,0.421622770741166,0.494729291170585,10,"CASP3; DFFA; DFFB; H1F0; HIST1H1C; HIST1H1D; HIST1H1E; HMGB2; KPNA1; KPNB1"
"R-HSA-2408522","Selenoamino acid metabolism",0.123189240643254,0.180968770392277,0.496048051837948,58,"AHCY; AIMP1; AIMP2; CBS; CTH; DARS; EEF1E1; EEFSEC; EPRS; FAU; GNMT; GSR; HNMT; IARS; INMT; KARS; LARS; MARS; MAT1A; NNMT; PAPSS1; PAPSS2; PSTK; QARS; RARS; RPL10A; RPL12; RPL13; RPL13A; RPL14; RPL15; RPL17; RPL18; RPL18A; RPL19; RPL21; RPL22L1; RPL23A; RPL26; RPL26L1; RPL27A; RPL28; RPL29; RPL3; RPL30; RPL31; RPL32; RPL34; RPL35; RPL35A; RPL36; RPL36AL; RPL37; RPL38; RPL39L; RPL3L; RPL4; RPL41"
"R-HSA-8941326","RUNX2 regulates bone development",0.174127780291434,0.25811617133308,0.499923504223016,28,"ABL1; BGLAP; CBFB; COL1A1; GLI2; GLI3; HDAC3; HDAC4; HES1; HEY1; HEY2; IHH; MAF; MAPK1; MAPK3; RB1; RBM14; RUNX2; SATB2; SMAD1; SMAD4; SP7; SRC; UCMA; WWTR1; YAP1; YES1; ZNF521"
"R-HSA-1606322","ZBP1(DAI) mediated induction of type I IFNs",-0.192247476687539,0.286040924998693,0.501521436356139,23,"AGER; APP; CHUK; DTX4; IKBKB; IRF3; MYD88; NFKB1; NFKB2; NFKBIA; NFKBIB; NKIRAS1; NLRP4; RELA; RIPK1; RIPK3; S100A12; S100B; SAA1; TBK1; TICAM1; TLR3; ZBP1"
"R-HSA-427359","SIRT1 negatively regulates rRNA expression",0.208732663501063,0.311277514354231,0.502495930816973,19,"H2AFJ; H2AFV; H2AFX; H2AFZ; H2BFS; H3F3A; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HIST2H2AA3; HIST2H2AC; RRP8; SIRT1; TAF1A; TAF1B; TAF1C; TAF1D; TBP"
"R-HSA-8964043","Plasma lipoprotein clearance",-0.171331904143467,0.255538126759366,0.502555091455453,29,"AMN; AP2A1; AP2A2; AP2B1; AP2M1; AP2S1; APOA1; APOB; CES3; CLTA; CLTC; CUBN; HDLBP; LDLR; LDLRAP1; LIPA; LIPC; LSR; MYLIP; NCEH1; NPC1; NPC2; NR1H2; NR1H3; PCSK9; SCARB1; SOAT1; SOAT2; VLDLR"
"R-HSA-9013508","NOTCH3 Intracellular Domain Regulates Transcription",0.198414840778501,0.296687197037091,0.503643617163988,21,"EP300; FABP7; HES1; HES5; HEY1; HEY2; HEYL; IKZF1; KAT2A; KAT2B; MAML1; MAML2; MAML3; NOTCH1; NOTCH3; PBX1; PLXND1; RBPJ; SNW1; STAT1; WWC1"
"R-HSA-373752","Netrin-1 signaling",0.138479239628222,0.207186922069702,0.503892153234694,44,"ABLIM1; ABLIM2; ABLIM3; AGAP2; CDC42; DCC; DOCK1; DSCAM; DSCAML1; EZR; FYN; MAPK11; MAPK12; MAPK13; MAPK14; MAPK8; MYO10; NCK1; NEO1; NTN1; NTN4; PAK1; PITPNA; PLCG1; PRKCQ; PTK2; RAC1; RGMA; RGMB; ROBO1; SIAH2; SLIT2; SLIT3; SRC; TRIO; TRPC1; TRPC3; TRPC4; TRPC6; UNC5A; UNC5B; UNC5C; UNC5D; WASL"
"R-HSA-375170","CDO in myogenesis",-0.187080643751494,0.280235590959792,0.504399522355318,24,"ABL1; BNIP2; BOC; CDC42; CDH15; CDH2; CDH4; CDON; CTNNA1; CTNNA2; CTNNB1; MAP2K6; MAPK11; MAPK12; MAPK14; MEF2A; MEF2B; MEF2C; MEF2D; NEO1; SPAG9; TCF12; TCF3; TCF4"
"R-HSA-525793","Myogenesis",-0.187080643751494,0.280235590959792,0.504399522355318,24,"ABL1; BNIP2; BOC; CDC42; CDH15; CDH2; CDH4; CDON; CTNNA1; CTNNA2; CTNNB1; MAP2K6; MAPK11; MAPK12; MAPK14; MEF2A; MEF2B; MEF2C; MEF2D; NEO1; SPAG9; TCF12; TCF3; TCF4"
"R-HSA-5210891","Uptake and function of anthrax toxins",-0.271955461964733,0.407509927197805,0.50454277851588,11,"ANTXR1; ANTXR2; CALM1; FURIN; MAP2K1; MAP2K2; MAP2K3; MAP2K4; MAP2K6; MAP2K7; PDCD6IP"
"R-HSA-4839735","AXIN mutants destabilize the destruction complex, activating WNT signaling",0.248890525384472,0.373198148879559,0.504828000491231,13,"APC; AXIN1; CSNK1A1; GSK3B; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5A; PPP2R5B; PPP2R5C; PPP2R5D; PPP2R5E"
"R-HSA-4839744","truncated APC mutants destabilize the destruction complex",0.248890525384472,0.373198148879559,0.504828000491231,13,"APC; AXIN1; CSNK1A1; GSK3B; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5A; PPP2R5B; PPP2R5C; PPP2R5D; PPP2R5E"
"R-HSA-4839748","AMER1 mutants destabilize the destruction complex",0.248890525384472,0.373198148879559,0.504828000491231,13,"APC; AXIN1; CSNK1A1; GSK3B; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5A; PPP2R5B; PPP2R5C; PPP2R5D; PPP2R5E"
"R-HSA-5467337","APC truncation mutants have impaired AXIN binding",0.248890525384472,0.373198148879559,0.504828000491231,13,"APC; AXIN1; CSNK1A1; GSK3B; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5A; PPP2R5B; PPP2R5C; PPP2R5D; PPP2R5E"
"R-HSA-5467340","AXIN missense mutants destabilize the destruction complex",0.248890525384472,0.373198148879559,0.504828000491231,13,"APC; AXIN1; CSNK1A1; GSK3B; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5A; PPP2R5B; PPP2R5C; PPP2R5D; PPP2R5E"
"R-HSA-5467348","Truncations of AMER1 destabilize the destruction complex",0.248890525384472,0.373198148879559,0.504828000491231,13,"APC; AXIN1; CSNK1A1; GSK3B; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5A; PPP2R5B; PPP2R5C; PPP2R5D; PPP2R5E"
"R-HSA-8957275","Post-translational protein phosphorylation",0.124688186222897,0.18745749031532,0.505951703063729,54,"ADAM10; ALB; AMTN; ANO8; APLP2; APOA1; APOA2; APOB; APOL1; APP; BMP4; BPIFB2; C3; C4A; CALU; CDH2; CHGB; CKAP4; CP; CSF1; CST3; DNAJC3; EVA1A; F5; FAM20A; FAM20C; FBN1; FGA; FGG; FN1; FSTL1; FSTL3; FUCA2; GAS6; GOLM1; HRC; HSP90B1; IGFBP1; IGFBP3; IGFBP4; IGFBP5; IGFBP7; ITIH2; KNG1; KTN1; LAMB1; LAMB2; LAMC1; LGALS1; LTBP1; MATN3; MBTPS1; MELTF; MEN1"
"R-HSA-1433559","Regulation of KIT signaling",0.239638753646147,0.360350847241016,0.506040836975717,14,"CBL; FYN; GRB2; KIT; LYN; PRKCA; PTPN6; SH2B2; SH2B3; SOCS1; SOCS6; SOS1; SRC; YES1"
"R-HSA-416993","Trafficking of GluR2-containing AMPA receptors",-0.25030706456259,0.37657119866795,0.506242073080249,13,"AP2A1; AP2A2; AP2B1; AP2M1; AP2S1; GRIA1; GRIA2; GRIA4; GRIP1; NSF; PICK1; PRKCA; PRKCB"
"R-HSA-5655302","Signaling by FGFR1 in disease",0.15839573354278,0.23840401433212,0.506434047238441,33,"BCR; CNTRL; CPSF6; CUX1; ERLIN2; FGF1; FGF17; FGF2; FGF20; FGF5; FGF9; FGFR1; FGFR1OP; FGFR1OP2; FRS2; GAB1; GAB2; GRB2; HRAS; KRAS; LRRFIP1; MYO18A; NRAS; PIK3CA; PIK3R1; PLCG1; SOS1; STAT1; STAT3; STAT5A; STAT5B; TRIM24; ZMYM2"
"R-HSA-166208","mTORC1-mediated signalling",0.201309123972711,0.303829227948272,0.507603896592316,20,"AKT1S1; EEF2K; EIF4B; EIF4E; EIF4G1; LAMTOR2; LAMTOR3; LAMTOR4; LAMTOR5; MLST8; MTOR; RHEB; RPS6; RPS6KB1; RPTOR; RRAGA; RRAGC; RRAGD; SLC38A9; YWHAB"
"R-HSA-977225","Amyloid fiber formation",0.140031807597131,0.211988404498227,0.508892267468847,42,"APOA1; APP; B2M; BACE1; CALB1; CALCA; CST3; FGA; FURIN; GGA1; GGA2; GGA3; GSN; H2AFX; H2AFZ; H2BFS; H3F3A; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HIST2H2AA3; HIST2H2AC; HSPG2; ITM2B; LTF; LYZ; MFGE8; NAT8; NPPA; ODAM; PRL; SAA1; SEMG1; SIAH2; SNCA; SNCAIP; SORL1; TGFBI; TTR; UBA52; UBC"
"R-HSA-5365859","RA biosynthesis pathway",0.200124343869629,0.30389156262129,0.510192060579565,20,"ADH1A; ADH4; AKR1C3; ALDH1A1; ALDH1A2; ALDH1A3; ALDH8A1; CRABP1; CYP26B1; CYP26C1; DHRS3; DHRS4; DHRS9; RDH10; RDH11; RDH13; RDH14; RDH16; RDH5; SDR16C5"
"R-HSA-165054","Rev-mediated nuclear export of HIV RNA",-0.165194138151271,0.251437208446063,0.511181192132483,30,"NDC1; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188; NUP205; NUP210; NUP214; NUP35; NUP43; NUP50; NUP54; NUP58; NUP62; NUP85; NUP88; NUP93; NUP98; NUPL2; POM121; RAE1; RAN; RANBP1; RANBP2; RANGAP1; RCC1; SEH1L; XPO1"
"R-HSA-975578","Reactions specific to the complex N-glycan synthesis pathway",0.277573263315013,0.422661420192891,0.511356322960901,10,"CGA; CHST10; CHST8; FUCA1; FUT3; FUT8; LHB; MAN2A1; MAN2A2; MGAT2"
"R-HSA-166520","Signalling by NGF",-0.119482167344616,0.181956210132157,0.511403792753923,58,"ABR; ADAM17; ADCYAP1; ADCYAP1R1; ADORA2A; AKAP13; AP2A1; AP2A2; AP2B1; AP2M1; AP2S1; APH1A; APH1B; ARHGDIA; ARHGEF10; ARHGEF10L; ARHGEF11; ARHGEF12; ARHGEF15; ARHGEF16; ARHGEF17; ARHGEF18; ARHGEF19; ARHGEF2; ARHGEF26; ARHGEF3; ARHGEF33; ARHGEF35; ARHGEF37; ARHGEF38; ARHGEF39; ARHGEF4; ARHGEF40; ARHGEF5; ARHGEF7; ATF1; BAD; BCL2L11; BRAF; CASP3; CLTA; CLTC; CRK; CRKL; DNAL4; DNM1; DNM2; DNM3; DUSP3; DUSP4; DUSP7; ECT2; FGD2; FGD3; FGD4; FRS2; FURIN; GNA13"
"R-HSA-936440","Negative regulators of DDX58/IFIH1 signaling",-0.170508510073904,0.26006398332004,0.512055386287465,28,"ATG12; ATG5; CYLD; DDX58; IFIH1; IRF3; ISG15; ITCH; MAVS; NLRC5; NLRX1; PCBP2; PIN1; RNF125; RNF135; RNF216; TAX1BP1; TBK1; TNFAIP3; TRAF3; TRIM25; UBA52; UBA7; UBC; UBE2D1; UBE2D3; UBE2K; UBE2L6"
"R-HSA-420092","Glucagon-type ligand receptors",0.178228228660964,0.272920925455807,0.51373061552287,25,"ADCYAP1; ADCYAP1R1; GCG; GLP1R; GLP2R; GNAS; GNB1; GNB2; GNB3; GNB4; GNB5; GNG10; GNG11; GNG12; GNG2; GNG3; GNG4; GNG5; GNG7; GNGT2; SCT; SCTR; VIP; VIPR1; VIPR2"
"R-HSA-71291","Metabolism of amino acids and derivatives",0.11267351530915,0.172552972062978,0.513769637010443,64,"AADAT; AANAT; AASS; ACAD8; ACADSB; ACAT1; ACMSD; ADI1; ADO; AFMID; AGMAT; AGXT; AHCY; AIMP1; AIMP2; ALDH18A1; ALDH4A1; ALDH6A1; ALDH7A1; ALDH9A1; AMD1; AMDHD1; AMT; APIP; ARG1; ARG2; ASL; ASNS; ASPA; ASPG; ASRGL1; ASS1; AUH; AZIN1; AZIN2; BBOX1; BCAT1; BCAT2; BCKDHA; BCKDHB; BCKDK; BHMT; BHMT2; CARNMT1; CARNS1; CBS; CDO1; CGA; CHDH; CKB; CKMT1A; CKMT2; CPS1; CRYM; CSAD; CTH; DARS; DBH; DBT; DCT; DDC; DDO; DHTKD1; DIO1"
"R-HSA-162599","Late Phase of HIV Life Cycle",-0.116241433820674,0.178965524150141,0.516003238418551,60,"CCNH; CCNK; CCNT1; CCNT2; CDK7; CDK9; CHMP2A; CHMP2B; CHMP3; CHMP4A; CHMP4B; CHMP4C; CHMP5; CHMP6; CHMP7; CTDP1; ELL; ELOA; ELOC; ERCC3; FURIN; GTF2A1; GTF2A2; GTF2B; GTF2E1; GTF2E2; GTF2F1; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; GTF2H5; MNAT1; MVB12A; MVB12B; NCBP1; NCBP2; NDC1; NEDD4L; NELFA; NELFB; NELFCD; NELFE; NMT1; NMT2; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188; NUP205; NUP210; NUP214; NUP35; NUP43; NUP50; NUP54; NUP58"
"R-HSA-9020702","Interleukin-1 signaling",0.11855815525952,0.18262649027668,0.516219594530133,57,"AGER; APP; BTRC; CHUK; CUL1; FBXW11; IKBKB; IL1A; IL1B; IL1R1; IL1R2; IL1RAP; IL1RN; IRAK2; IRAK3; IRAK4; MAP2K1; MAP2K4; MAP2K6; MAP3K3; MAP3K7; MAP3K8; MYD88; NFKB1; NFKB2; NFKBIA; NFKBIB; NKIRAS1; NOD1; NOD2; PELI1; PELI2; PELI3; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9; PSMC1; PSMC2; PSMC3; PSMC4; PSMC5; PSMC6; PSMD1; PSMD11; PSMD12; PSMD13"
"R-HSA-4641263","Regulation of FZD by ubiquitination",0.206375697602496,0.319945145729234,0.518904746571666,18,"FZD4; FZD5; FZD6; FZD8; LGR4; LGR5; LGR6; LRP5; LRP6; RNF43; RSPO1; RSPO2; RSPO3; RSPO4; UBA52; UBC; USP8; ZNRF3"
"R-HSA-1614635","Sulfur amino acid metabolism",-0.188717503804716,0.292578318291072,0.518917244047487,22,"ADI1; ADO; AHCY; APIP; BHMT; BHMT2; CBS; CDO1; CSAD; CTH; ENOPH1; ETHE1; GOT1; MAT1A; MRI1; MTAP; MTR; MTRR; SLC25A10; SUOX; TST; TSTD1"
"R-HSA-390522","Striated Muscle Contraction",0.169519184345628,0.263012108037322,0.519231834144213,27,"ACTN2; MYBPC1; MYBPC2; MYBPC3; MYH3; MYH6; MYL1; MYL3; MYL4; NEB; TMOD1; TMOD2; TMOD3; TMOD4; TNNC1; TNNC2; TNNI1; TNNI2; TNNI3; TNNT1; TNNT2; TNNT3; TPM1; TPM2; TPM4; TTN; VIM"
"R-HSA-76066","RNA Polymerase III Transcription Initiation From Type 2 Promoter",0.172545638087364,0.267877695412783,0.51949700026348,26,"BDP1; BRF1; CRCP; GTF3C1; GTF3C2; GTF3C3; GTF3C4; GTF3C5; GTF3C6; POLR1C; POLR1D; POLR2E; POLR2F; POLR2H; POLR2K; POLR2L; POLR3A; POLR3B; POLR3C; POLR3D; POLR3F; POLR3G; POLR3GL; POLR3H; POLR3K; TBP"
"R-HSA-69298","Association of licensing factors with the pre-replicative complex",-0.26268885992424,0.40829400265946,0.51997650189904,11,"CDC6; CDT1; E2F1; E2F2; GMNN; ORC1; ORC3; ORC4; ORC5; UBA52; UBC"
"R-HSA-3000178","ECM proteoglycans",0.122608341277795,0.192886241311039,0.52500388974064,51,"ACAN; AGRN; ASPN; BCAN; COL9A1; COL9A2; COL9A3; COMP; DAG1; DCN; FMOD; HAPLN1; HSPG2; IBSP; ITGA2; ITGA2B; ITGA7; ITGA8; ITGA9; ITGAV; ITGAX; ITGB1; ITGB3; ITGB5; ITGB6; LAMA1; LAMA2; LAMA3; LAMA4; LAMA5; LAMB1; LAMB2; LAMC1; LRP4; LUM; MATN1; MATN3; MATN4; MUSK; NCAM1; PTPRS; SERPINE1; SPARC; TGFB1; TGFB2; TGFB3; TNC; TNN; TNXB; VCAN; VTN"
"R-HSA-6803204","TP53 Regulates Transcription of Genes Involved in Cytochrome C Release",0.202694770095828,0.320153054899973,0.526656367750455,18,"AIFM2; ATM; BAX; BBC3; BID; BNIP3L; PMAIP1; PPP1R13B; PRELID1; PRELID3A; STEAP3; TP53AIP1; TP53BP2; TP53INP1; TP63; TP73; TRIAP1; ZNF420"
"R-HSA-141424","Amplification of signal from the kinetochores",-0.118271689130152,0.186822293019028,0.526687582225663,55,"AHCTF1; AURKB; B9D2; BIRC5; BUB1B; BUB3; CENPA; CENPC; CENPE; CENPF; CENPH; CENPK; CENPL; CENPM; CENPN; CENPO; CENPP; CENPQ; CENPT; CENPU; CKAP5; CLASP1; CLIP1; DSN1; DYNC1H1; DYNC1I1; DYNC1I2; DYNC1LI1; DYNC1LI2; DYNLL1; DYNLL2; INCENP; ITGB3BP; KIF2A; KIF2C; KNTC1; MAD1L1; MAD2L1; MAPRE1; MIS12; NDE1; NDEL1; NSL1; NUDC; NUF2; NUP107; NUP133; NUP160; NUP43; NUP85; NUP98; PAFAH1B1; PLK1; PMF1; PPP2CA"
"R-HSA-141444","Amplification  of signal from unattached  kinetochores via a MAD2  inhibitory signal",-0.118271689130152,0.186822293019028,0.526687582225663,55,"AHCTF1; AURKB; B9D2; BIRC5; BUB1B; BUB3; CENPA; CENPC; CENPE; CENPF; CENPH; CENPK; CENPL; CENPM; CENPN; CENPO; CENPP; CENPQ; CENPT; CENPU; CKAP5; CLASP1; CLIP1; DSN1; DYNC1H1; DYNC1I1; DYNC1I2; DYNC1LI1; DYNC1LI2; DYNLL1; DYNLL2; INCENP; ITGB3BP; KIF2A; KIF2C; KNTC1; MAD1L1; MAD2L1; MAPRE1; MIS12; NDE1; NDEL1; NSL1; NUDC; NUF2; NUP107; NUP133; NUP160; NUP43; NUP85; NUP98; PAFAH1B1; PLK1; PMF1; PPP2CA"
"R-HSA-1482925","Acyl chain remodelling of PG",-0.222398027574572,0.352371149750314,0.527944350220957,15,"CRLS1; LPCAT1; LPCAT4; LPGAT1; PLA2G10; PLA2G12A; PLA2G1B; PLA2G2A; PLA2G2D; PLA2G4A; PLA2G4B; PLA2G4D; PLA2G4F; PLA2G5; PLA2R1"
"R-HSA-6802946","Signaling by moderate kinase activity BRAF mutants",0.144223128185909,0.228743590993966,0.528366661951488,36,"APBB1IP; ARRB1; ARRB2; BRAF; BRAP; CNKSR1; CSK; FGA; FGB; FGG; FN1; HRAS; IQGAP1; ITGA2B; ITGB3; JAK2; KRAS; KSR1; KSR2; MAP2K1; MAP2K2; MAP3K11; MAPK1; MAPK3; MARK3; NRAS; PEBP1; PHB; RAF1; RAP1A; RAP1B; SRC; TLN1; VCL; VWF; YWHAB"
"R-HSA-6802955","Paradoxical activation of RAF signaling by kinase inactive BRAF",0.144223128185909,0.228743590993966,0.528366661951488,36,"APBB1IP; ARRB1; ARRB2; BRAF; BRAP; CNKSR1; CSK; FGA; FGB; FGG; FN1; HRAS; IQGAP1; ITGA2B; ITGB3; JAK2; KRAS; KSR1; KSR2; MAP2K1; MAP2K2; MAP3K11; MAPK1; MAPK3; MARK3; NRAS; PEBP1; PHB; RAF1; RAP1A; RAP1B; SRC; TLN1; VCL; VWF; YWHAB"
"R-HSA-1296041","Activation of G protein gated Potassium channels",-0.18392003214552,0.292759830818328,0.529854346063472,22,"GABBR1; GABBR2; GNB1; GNB2; GNB3; GNG10; GNG12; GNG2; GNG3; GNG4; GNG5; GNG7; GNGT2; KCNJ10; KCNJ12; KCNJ15; KCNJ16; KCNJ2; KCNJ3; KCNJ4; KCNJ5; KCNJ6"
"R-HSA-1296059","G protein gated Potassium channels",-0.18392003214552,0.292759830818328,0.529854346063472,22,"GABBR1; GABBR2; GNB1; GNB2; GNB3; GNG10; GNG12; GNG2; GNG3; GNG4; GNG5; GNG7; GNGT2; KCNJ10; KCNJ12; KCNJ15; KCNJ16; KCNJ2; KCNJ3; KCNJ4; KCNJ5; KCNJ6"
"R-HSA-997272","Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits",-0.18392003214552,0.292759830818328,0.529854346063472,22,"GABBR1; GABBR2; GNB1; GNB2; GNB3; GNG10; GNG12; GNG2; GNG3; GNG4; GNG5; GNG7; GNGT2; KCNJ10; KCNJ12; KCNJ15; KCNJ16; KCNJ2; KCNJ3; KCNJ4; KCNJ5; KCNJ6"
"R-HSA-446353","Cell-extracellular matrix interactions",-0.237018150561101,0.377492455348048,0.530085698954144,13,"ACTN1; FBLIM1; FERMT2; FLNC; ILK; ITGB1; LIMS1; LIMS2; PARVA; PARVB; PXN; RSU1; TESK1"
"R-HSA-8854691","Interleukin-20 family signaling",0.195386928414976,0.3120026307778,0.531160895578773,19,"IFNLR1; IL10RB; IL19; IL20; IL20RA; IL20RB; IL22RA1; IL26; JAK1; JAK2; JAK3; SOCS3; STAT1; STAT2; STAT3; STAT4; STAT5A; STAT5B; TYK2"
"R-HSA-6811436","COPI-independent Golgi-to-ER retrograde traffic",-0.152583169464117,0.243812533360873,0.531431909378463,32,"ACTR10; ACTR1A; AGPAT3; BICD1; BICD2; CAPZA1; CAPZA2; CAPZA3; CAPZB; DCTN1; DCTN2; DCTN4; DCTN5; DCTN6; DYNC1H1; DYNC1I1; DYNC1I2; DYNC1LI1; DYNC1LI2; DYNLL1; DYNLL2; GALNT1; GALNT2; PAFAH1B1; PAFAH1B2; PAFAH1B3; PLA2G4A; PLA2G6; RAB18; RAB3GAP2; RAB6A; RAB6B"
"R-HSA-75893","TNF signaling",-0.149715326340396,0.240176198912547,0.533050463998718,33,"ADAM17; BIRC2; BIRC3; CASP8; CHUK; CLIP3; CYLD; FADD; IKBKB; MADD; MAP3K7; NSMAF; OTULIN; RACK1; RBCK1; RIPK1; RNF31; SHARPIN; SMPD2; SMPD3; SPPL2A; TAB1; TAB2; TAX1BP1; TNF; TNFAIP3; TNFRSF1A; TRAF1; TRAF2; UBA52; UBC; USP2; USP4"
"R-HSA-6794362","Protein-protein interactions at synapses",-0.113018212852109,0.182033974259179,0.534689574106725,58,"APBA1; APBA2; APBA3; BEGAIN; DBNL; DLG1; DLG2; DLG4; DLGAP1; DLGAP2; DLGAP3; DLGAP4; EPB41; EPB41L1; EPB41L2; EPB41L3; EPB41L5; FLOT1; FLOT2; GRIA1; GRIA4; GRIN1; GRIN2A; GRIN2B; GRIN2C; GRIN2D; GRM1; GRM5; HOMER1; HOMER2; HOMER3; IL1RAP; LIN7A; LIN7B; LIN7C; LRFN1; LRFN2; LRFN3; LRFN4; LRRC4B; LRRTM1; LRRTM3; LRRTM4; NLGN1; NRXN1; NRXN2; NRXN3; NTRK3; PDLIM5; PPFIA1; PPFIA2; PPFIA3; PPFIA4; PPFIBP1; PPFIBP2; PTPRD; PTPRF; PTPRS"
"R-HSA-168164","Toll Like Receptor 3 (TLR3) Cascade",0.11326740944193,0.182728488695515,0.535345175696746,57,"AGER; APP; ATF1; ATF2; BIRC2; BIRC3; BTRC; CASP8; CD14; CHUK; CUL1; DUSP3; DUSP4; DUSP7; FADD; FBXW11; FOS; IKBKB; IRAK2; IRF3; IRF7; LY96; MAP2K1; MAP2K3; MAP2K4; MAP2K6; MAP2K7; MAP3K7; MAP3K8; MAPK1; MAPK10; MAPK11; MAPK14; MAPK3; MAPK8; MAPK9; MAPKAPK2; MAPKAPK3; MEF2A; MEF2C; MYD88; NFKB1; NFKB2; NFKBIA; NFKBIB; NKIRAS1; NOD1; NOD2; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5D; RELA; RIPK1; RIPK2; RIPK3"
"R-HSA-983705","Signaling by the B Cell Receptor (BCR)",0.184293468759039,0.297383214265966,0.535444043099365,21,"AHCYL1; BCL10; BLK; BLNK; BTRC; CALM1; CARD11; CBL; CBLB; CD19; CD22; CD79A; CD79B; CHUK; CUL1; DAPP1; FBXW11; FKBP1A; FYN; GRB2; HRAS"
"R-HSA-141405","Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components",0.204006897259277,0.329329314427623,0.535612244951137,17,"ANAPC1; ANAPC10; ANAPC11; ANAPC15; ANAPC16; ANAPC2; ANAPC4; ANAPC5; ANAPC7; BUB1B; BUB3; CDC16; CDC26; CDC27; MAD2L1; UBE2D1; UBE2E1"
"R-HSA-141430","Inactivation of APC/C via direct inhibition of the APC/C complex",0.204006897259277,0.329329314427623,0.535612244951137,17,"ANAPC1; ANAPC10; ANAPC11; ANAPC15; ANAPC16; ANAPC2; ANAPC4; ANAPC5; ANAPC7; BUB1B; BUB3; CDC16; CDC26; CDC27; MAD2L1; UBE2D1; UBE2E1"
"R-HSA-75035","Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex",-0.242619760445856,0.392470409245962,0.536452656864701,12,"CCNB1; CDK1; CHEK1; CHEK2; SFN; WEE1; YWHAB; YWHAE; YWHAG; YWHAH; YWHAQ; YWHAZ"
"R-HSA-156827","L13a-mediated translational silencing of Ceruloplasmin expression",-0.114442164584106,0.185209127207782,0.536636116170827,56,"EIF2S1; EIF2S2; EIF3A; EIF3B; EIF3C; EIF3D; EIF3E; EIF3F; EIF3G; EIF3H; EIF3I; EIF3J; EIF3K; EIF3L; EIF3M; EIF4A1; EIF4A2; EIF4B; EIF4E; EIF4G1; EIF4H; FAU; PABPC1; RPL10A; RPL12; RPL13; RPL13A; RPL14; RPL15; RPL17; RPL18; RPL18A; RPL19; RPL21; RPL22L1; RPL23A; RPL26; RPL26L1; RPL27A; RPL28; RPL29; RPL3; RPL30; RPL31; RPL32; RPL34; RPL35; RPL35A; RPL36; RPL36AL; RPL37; RPL38; RPL39L; RPL3L; RPL4; RPL41"
"R-HSA-6811558","PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling",0.117931958265969,0.191137099147549,0.537233455482381,52,"AKT1; BTC; CD19; CD28; CD80; CD86; EGF; EGFR; ERBB2; ERBB3; ERBB4; EREG; ESR1; ESR2; FGF1; FGF10; FGF17; FGF18; FGF2; FGF20; FGF22; FGF5; FGF7; FGF9; FGFR1; FGFR2; FGFR3; FGFR4; FRS2; FYN; GAB1; GRB2; HGF; IER3; IL1RAP; IL1RL1; IL33; INSR; IRAK4; IRS1; IRS2; KIT; KL; KLB; MAPK1; MAPK3; MET; MYD88; NRG1; NRG4; PDGFB; PDGFRA"
"R-HSA-2262752","Cellular responses to stress",0.108133475849389,0.175366957724556,0.537490281327953,62,"ACD; ACTR10; ACTR1A; AGO1; AGO3; AGO4; AJUBA; AKT1S1; ANAPC1; ANAPC10; ANAPC11; ANAPC15; ANAPC16; ANAPC2; ANAPC4; ANAPC5; ANAPC7; AQP8; ARNT; ASF1A; ATM; ATOX1; ATR; BAG1; BAG2; BAG3; BAG5; BMI1; CA9; CABIN1; CAMK2A; CAMK2B; CAMK2D; CAMK2G; CAPZA1; CAPZA2; CAPZA3; CAPZB; CAT; CBX2; CBX4; CBX6; CBX8; CCAR2; CCNA1; CCNA2; CCNE1; CCNE2; CCS; CDC16; CDC26; CDC27; CDK2; CDK4; CDK6; CDKN1B; CDKN2A; CDKN2B; CDKN2C; CDKN2D; CEBPB; CITED2"
"R-HSA-8963898","Plasma lipoprotein assembly",0.239849346304593,0.389129360226459,0.537647495497727,12,"A2M; ABCA1; APOA1; APOA2; APOB; APOC3; BMP1; MTTP; P4HB; PRKACB; SAR1B; ZDHHC8"
"R-HSA-73887","Death Receptor Signalling",-0.134575270363518,0.218565730556481,0.538079399201207,40,"ADAM17; BIRC2; BIRC3; CASP10; CASP8; CFLAR; CHUK; CLIP3; CYLD; FADD; FAS; FASLG; IKBKB; MADD; MAP3K7; NSMAF; OTULIN; RACK1; RBCK1; RIPK1; RNF31; SHARPIN; SMPD2; SMPD3; SPPL2A; TAB1; TAB2; TAX1BP1; TNF; TNFAIP3; TNFRSF10A; TNFRSF10B; TNFRSF1A; TNFSF10; TRAF1; TRAF2; UBA52; UBC; USP2; USP4"
"R-HSA-202733","Cell surface interactions at the vascular wall",0.136904182126415,0.222882865483641,0.539054933815714,38,"ANGPT1; ANGPT2; ANGPT4; APOB; ATP1B1; ATP1B2; ATP1B3; BSG; CAV1; CD2; CD244; CD44; CD47; CD48; CD58; CD84; CEACAM1; CEACAM3; CEACAM5; CEACAM6; CXADR; DOK2; EPCAM; ESAM; F11R; F2; FCER1G; FN1; FYN; GAS6; GLG1; GP6; GPC1; GRB14; GRB2; GRB7; GYPC; HRAS"
"R-HSA-156581","Methylation",-0.223879374387243,0.364615654566051,0.539205608573231,14,"AHCY; AS3MT; COMT; CYP1A2; GSTO1; MAT1A; MAT2A; MAT2B; MTR; MTRR; N6AMT1; NNMT; TPMT; TRMT112"
"R-HSA-8939243","RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known",0.146570118548832,0.238785095708542,0.539336905786569,33,"ACTL6A; ARID1B; ARID2; AUTS2; BMI1; CBFB; CBX2; CBX4; CBX6; CBX8; CSNK2A2; CSNK2B; EP300; HIPK2; PBRM1; PCGF5; PHC1; PHC2; PHC3; RING1; RNF2; RYBP; SCMH1; SMARCA2; SMARCA4; SMARCB1; SMARCC1; SMARCC2; SMARCD1; SMARCD2; SMARCD3; SMARCE1; YAF2"
"R-HSA-211897","Cytochrome P450 - arranged by substrate type",-0.109305706706111,0.179043981686303,0.541533025779742,60,"AHR; ARNT; ARNT2; CYP11A1; CYP11B1; CYP17A1; CYP19A1; CYP1A1; CYP1A2; CYP1B1; CYP21A2; CYP24A1; CYP26B1; CYP26C1; CYP27A1; CYP27B1; CYP2A13; CYP2A6; CYP2A7; CYP2C18; CYP2C19; CYP2C8; CYP2C9; CYP2D6; CYP2E1; CYP2F1; CYP2J2; CYP2R1; CYP2S1; CYP2U1; CYP2W1; CYP39A1; CYP3A43; CYP3A5; CYP3A7; CYP46A1; CYP4A11; CYP4A22; CYP4B1; CYP4F11; CYP4F12; CYP4F2; CYP4F22; CYP4F3; CYP4V2; CYP51A1; CYP7A1; CYP7B1; CYP8B1; FDX1; FDX2; FDXR; NCOA1; NCOA2; NR1H4; POMC; POR; PTGIS; RXRA; TBXAS1"
"R-HSA-975576","N-glycan antennae elongation in the medial/trans-Golgi",-0.167944361967943,0.275235612356556,0.541739939249787,25,"B4GALT1; B4GALT2; B4GALT3; B4GALT4; B4GALT5; B4GALT6; CGA; CHST10; CHST8; FUCA1; FUT3; FUT8; LHB; MAN2A1; MAN2A2; MGAT2; MGAT3; MGAT4A; MGAT4B; MGAT4C; MGAT5; ST3GAL4; ST6GAL1; ST8SIA2; ST8SIA6"
"R-HSA-877312","Regulation of IFNG signaling",0.237272696879097,0.389333776954276,0.542237733448719,12,"IFNGR1; IFNGR2; JAK1; JAK2; PIAS1; PTPN1; PTPN2; PTPN6; SOCS1; SOCS3; STAT1; SUMO1"
"R-HSA-166058","MyD88:Mal cascade initiated on plasma membrane",0.111297618932639,0.182765547458888,0.542548373365302,57,"AGER; APP; ATF1; ATF2; BTRC; CD14; CD36; CHUK; CUL1; DUSP3; DUSP4; DUSP7; ECSIT; FBXW11; FOS; IKBKB; IRAK2; IRAK3; IRAK4; LY96; MAP2K1; MAP2K3; MAP2K4; MAP2K6; MAP2K7; MAP3K1; MAP3K7; MAP3K8; MAPK1; MAPK10; MAPK11; MAPK14; MAPK3; MAPK8; MAPK9; MAPKAPK2; MAPKAPK3; MEF2A; MEF2C; MYD88; NFKB1; NFKB2; NFKBIA; NFKBIB; NKIRAS1; NOD1; NOD2; PELI1; PELI2; PELI3; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5D; RELA; RIPK2"
"R-HSA-168179","Toll Like Receptor TLR1:TLR2 Cascade",0.111297618932639,0.182765547458888,0.542548373365302,57,"AGER; APP; ATF1; ATF2; BTRC; CD14; CD36; CHUK; CUL1; DUSP3; DUSP4; DUSP7; ECSIT; FBXW11; FOS; IKBKB; IRAK2; IRAK3; IRAK4; LY96; MAP2K1; MAP2K3; MAP2K4; MAP2K6; MAP2K7; MAP3K1; MAP3K7; MAP3K8; MAPK1; MAPK10; MAPK11; MAPK14; MAPK3; MAPK8; MAPK9; MAPKAPK2; MAPKAPK3; MEF2A; MEF2C; MYD88; NFKB1; NFKB2; NFKBIA; NFKBIB; NKIRAS1; NOD1; NOD2; PELI1; PELI2; PELI3; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5D; RELA; RIPK2"
"R-HSA-168188","Toll Like Receptor TLR6:TLR2 Cascade",0.111297618932639,0.182765547458888,0.542548373365302,57,"AGER; APP; ATF1; ATF2; BTRC; CD14; CD36; CHUK; CUL1; DUSP3; DUSP4; DUSP7; ECSIT; FBXW11; FOS; IKBKB; IRAK2; IRAK3; IRAK4; LY96; MAP2K1; MAP2K3; MAP2K4; MAP2K6; MAP2K7; MAP3K1; MAP3K7; MAP3K8; MAPK1; MAPK10; MAPK11; MAPK14; MAPK3; MAPK8; MAPK9; MAPKAPK2; MAPKAPK3; MEF2A; MEF2C; MYD88; NFKB1; NFKB2; NFKBIA; NFKBIB; NKIRAS1; NOD1; NOD2; PELI1; PELI2; PELI3; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5D; RELA; RIPK2"
"R-HSA-181438","Toll Like Receptor 2 (TLR2) Cascade",0.111297618932639,0.182765547458888,0.542548373365302,57,"AGER; APP; ATF1; ATF2; BTRC; CD14; CD36; CHUK; CUL1; DUSP3; DUSP4; DUSP7; ECSIT; FBXW11; FOS; IKBKB; IRAK2; IRAK3; IRAK4; LY96; MAP2K1; MAP2K3; MAP2K4; MAP2K6; MAP2K7; MAP3K1; MAP3K7; MAP3K8; MAPK1; MAPK10; MAPK11; MAPK14; MAPK3; MAPK8; MAPK9; MAPKAPK2; MAPKAPK3; MEF2A; MEF2C; MYD88; NFKB1; NFKB2; NFKBIA; NFKBIB; NKIRAS1; NOD1; NOD2; PELI1; PELI2; PELI3; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5D; RELA; RIPK2"
"R-HSA-445355","Smooth Muscle Contraction",-0.150221292675744,0.247751231263334,0.544289508247637,31,"ACTA2; ANXA1; ANXA2; ANXA6; CALD1; CALM1; CAV3; DYSF; ITGA1; ITGB5; LMOD1; MYH11; MYL12A; MYL12B; MYL5; MYL6; MYL6B; MYL7; MYL9; MYLK; PAK1; PAK2; PXN; SORBS1; SORBS3; TLN1; TPM1; TPM2; TPM4; TRIM72; VCL"
"R-HSA-1368108","BMAL1:CLOCK,NPAS2 activates circadian gene expression",0.133144818388978,0.220124569127823,0.545271203265719,39,"ARNTL; ARNTL2; BHLHE40; BHLHE41; CARM1; CHD9; CLOCK; CREM; CRTC1; CRY1; CRY2; DBP; EP300; F7; HDAC3; HIF1A; KLF15; NAMPT; NCOA1; NCOA2; NCOA6; NCOR1; NFIL3; NOCT; NPAS2; NR1D1; NR3C1; NRIP1; PER2; PPARA; PPARGC1A; RBM4; RORA; RXRA; SERPINE1; SIK1; SMARCD3; TBL1XR1; TGS1"
"R-HSA-500657","Presynaptic function of Kainate receptors",0.193090560092653,0.320680739467172,0.547089544141851,18,"GNB1; GNB2; GNB3; GNB4; GNB5; GNG10; GNG11; GNG12; GNG2; GNG3; GNG4; GNG5; GNG7; GNGT2; GRIK3; PLCB1; PLCB2; PLCB3"
"R-HSA-5578775","Ion homeostasis",-0.122287470933148,0.20410078827041,0.549071281700195,46,"ABCC9; AHCYL1; ASPH; ATP1A1; ATP1A2; ATP1A3; ATP1A4; ATP1B1; ATP1B2; ATP1B3; ATP2A1; ATP2A2; ATP2A3; ATP2B1; ATP2B2; ATP2B4; CALM1; CAMK2A; CAMK2B; CAMK2D; CAMK2G; FKBP1B; FXYD1; FXYD2; FXYD3; FXYD4; FXYD6; FXYD7; ITPR1; ITPR2; ITPR3; KCNJ11; NOS1; ORAI2; PLN; RYR1; RYR2; RYR3; SLC8A1; SLC8A3; SLN; SRI; STIM1; TNNI3; TRDN; TRPC1"
"R-HSA-162587","HIV Life Cycle",-0.107155624455366,0.179066954438187,0.549565768118844,60,"BANF1; CCNH; CCNK; CCNT1; CCNT2; CCR5; CD4; CDK7; CDK9; CHMP2A; CHMP2B; CHMP3; CHMP4A; CHMP4B; CHMP4C; CHMP5; CHMP6; CHMP7; CTDP1; CXCR4; ELL; ELOA; ELOC; ERCC3; FURIN; GTF2A1; GTF2A2; GTF2B; GTF2E1; GTF2E2; GTF2F1; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; GTF2H5; HMGA1; KPNA1; LIG1; LIG4; MNAT1; MVB12A; MVB12B; NCBP1; NCBP2; NDC1; NEDD4L; NELFA; NELFB; NELFCD; NELFE; NMT1; NMT2; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188"
"R-HSA-8866427","VLDLR internalisation and degradation",-0.23496387607871,0.393010344482601,0.549935539464025,12,"AP2A1; AP2A2; AP2B1; AP2M1; AP2S1; CLTA; CLTC; MYLIP; NR1H2; NR1H3; PCSK9; VLDLR"
"R-HSA-5654720","PI-3K cascade:FGFR4",0.223510482225956,0.37511395350971,0.551277516451224,13,"FGF1; FGF17; FGF18; FGF2; FGF20; FGF9; FGFR4; FRS2; GAB1; GRB2; KLB; PIK3CA; PIK3R1"
"R-HSA-5083625","Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)",0.223492611829909,0.375115240807634,0.55131071149322,13,"MUC1; MUC12; MUC13; MUC15; MUC16; MUC20; MUC21; MUC3A; MUC4; MUC5B; MUC6; MUC7; MUCL1"
"R-HSA-5083632","Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)",0.223492611829909,0.375115240807634,0.55131071149322,13,"MUC1; MUC12; MUC13; MUC15; MUC16; MUC20; MUC21; MUC3A; MUC4; MUC5B; MUC6; MUC7; MUCL1"
"R-HSA-5083636","Defective GALNT12 causes colorectal cancer 1 (CRCS1)",0.223492611829909,0.375115240807634,0.55131071149322,13,"MUC1; MUC12; MUC13; MUC15; MUC16; MUC20; MUC21; MUC3A; MUC4; MUC5B; MUC6; MUC7; MUCL1"
"R-HSA-1237044","Erythrocytes take up carbon dioxide and release oxygen",0.2529691287345,0.425007899498973,0.551702828534809,10,"AQP1; CA1; CA2; CA4; CYB5R1; CYB5R2; CYB5R4; CYB5RL; HBB; RHAG"
"R-HSA-1480926","O2/CO2 exchange in erythrocytes",0.2529691287345,0.425007899498973,0.551702828534809,10,"AQP1; CA1; CA2; CA4; CYB5R1; CYB5R2; CYB5R4; CYB5RL; HBB; RHAG"
"R-HSA-8956321","Nucleotide salvage",0.177138231809283,0.29771952882701,0.551854445277277,21,"ADA; ADAL; ADK; AMPD1; AMPD2; AMPD3; APRT; CDA; DCK; DGUOK; GMPR; GMPR2; PNP; TK1; TK2; TYMP; UCK1; UCK2; UCKL1; UPP1; UPP2"
"R-HSA-168274","Export of Viral Ribonucleoproteins from Nucleus",-0.156115735212529,0.265227802411482,0.556122928087196,27,"NDC1; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188; NUP205; NUP210; NUP214; NUP35; NUP43; NUP50; NUP54; NUP58; NUP62; NUP85; NUP88; NUP93; NUP98; NUPL2; POM121; RAE1; RAN; RANBP2; SEH1L; XPO1"
"R-HSA-168333","NEP/NS2 Interacts with the Cellular Export Machinery",-0.156115735212529,0.265227802411482,0.556122928087196,27,"NDC1; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188; NUP205; NUP210; NUP214; NUP35; NUP43; NUP50; NUP54; NUP58; NUP62; NUP85; NUP88; NUP93; NUP98; NUPL2; POM121; RAE1; RAN; RANBP2; SEH1L; XPO1"
"R-HSA-156711","Polo-like kinase mediated events",0.20546776402616,0.350444060407658,0.557669307784273,15,"CCNB1; CCNB2; CDC25A; CENPF; EP300; FOXM1; LIN37; LIN52; LIN54; LIN9; MYBL2; PKMYT1; PLK1; RBBP4; WEE1"
"R-HSA-6804116","TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest",0.228232761808021,0.390036099058583,0.558441451388535,12,"ARID3A; CCNA1; CCNA2; CCNE1; CCNE2; CDK2; CDKN1B; E2F1; E2F7; E2F8; PCBP4; ZNF385A"
"R-HSA-3560783","Defective B4GALT7 causes EDS, progeroid type",0.204241904888279,0.350520269364382,0.560107290361211,15,"AGRN; BCAN; CSPG4; CSPG5; DCN; GPC1; GPC2; GPC5; GPC6; HSPG2; SDC1; SDC2; SDC3; SDC4; VCAN"
"R-HSA-3560801","Defective B3GAT3 causes JDSSDHD",0.204241904888279,0.350520269364382,0.560107290361211,15,"AGRN; BCAN; CSPG4; CSPG5; DCN; GPC1; GPC2; GPC5; GPC6; HSPG2; SDC1; SDC2; SDC3; SDC4; VCAN"
"R-HSA-4420332","Defective B3GALT6 causes EDSP2 and SEMDJL1",0.204241904888279,0.350520269364382,0.560107290361211,15,"AGRN; BCAN; CSPG4; CSPG5; DCN; GPC1; GPC2; GPC5; GPC6; HSPG2; SDC1; SDC2; SDC3; SDC4; VCAN"
"R-HSA-167160","RNA Pol II CTD phosphorylation and interaction with CE during HIV infection",0.159226819033532,0.273691257294913,0.56071802940075,25,"CCNH; CDK7; ERCC3; GTF2F1; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; GTF2H5; MNAT1; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; RNGTT; RNMT; SUPT5H"
"R-HSA-77075","RNA Pol II CTD phosphorylation and interaction with CE",0.159226819033532,0.273691257294913,0.56071802940075,25,"CCNH; CDK7; ERCC3; GTF2F1; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4; GTF2H5; MNAT1; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; RNGTT; RNMT; SUPT5H"
"R-HSA-5173105","O-linked glycosylation",-0.100641803176034,0.174855970431442,0.56490604806115,63,"A4GNT; ADAMTS10; ADAMTS12; ADAMTS13; ADAMTS14; ADAMTS15; ADAMTS16; ADAMTS17; ADAMTS18; ADAMTS19; ADAMTS2; ADAMTS3; ADAMTS4; ADAMTS5; ADAMTS6; ADAMTS7; ADAMTS8; ADAMTS9; ADAMTSL1; ADAMTSL2; ADAMTSL3; ADAMTSL4; ADAMTSL5; B3GALNT2; B3GLCT; B3GNT2; B3GNT3; B3GNT4; B3GNT5; B3GNT6; B3GNT7; B3GNT8; B3GNT9; B3GNTL1; B4GALT5; B4GALT6; B4GAT1; C1GALT1; CHST4; DAG1; GALNT1; GALNT10; GALNT11; GALNT12; GALNT13; GALNT14; GALNT15; GALNT16; GALNT18; GALNT2; GALNT3; GALNT4; GALNT5; GALNT6; GALNT7; GALNT8; GALNT9; GALNTL5; GALNTL6; GCNT1; GCNT3; GCNT4; GCNT7"
"R-HSA-5083635","Defective B3GALTL causes Peters-plus syndrome (PpS)",-0.140451076291206,0.244089742892226,0.565015712060415,32,"ADAMTS10; ADAMTS12; ADAMTS13; ADAMTS14; ADAMTS15; ADAMTS16; ADAMTS17; ADAMTS18; ADAMTS19; ADAMTS2; ADAMTS3; ADAMTS4; ADAMTS5; ADAMTS6; ADAMTS7; ADAMTS8; ADAMTS9; ADAMTSL1; ADAMTSL2; ADAMTSL3; ADAMTSL4; ADAMTSL5; SBSPON; SEMA5A; SEMA5B; SPON2; THBS1; THBS2; THSD1; THSD4; THSD7A; THSD7B"
"R-HSA-186797","Signaling by PDGF",0.112179415155056,0.195006031846959,0.565114619039805,50,"BCAR1; COL4A1; COL4A2; COL4A3; COL4A4; COL6A1; COL6A2; COL6A3; COL6A5; COL6A6; COL9A1; COL9A2; COL9A3; CRK; CRKL; FURIN; GRB2; GRB7; HRAS; KRAS; NCK1; NCK2; NRAS; PDGFB; PDGFC; PDGFD; PDGFRA; PDGFRB; PIK3CA; PIK3CB; PIK3R1; PIK3R2; PLAT; PLCG1; PLG; PTPN12; RAPGEF1; RASA1; SOS1; SPP1; SRC; STAT1; STAT3; STAT5A; STAT5B; STAT6; THBS1; THBS2; THBS3; THBS4"
"R-HSA-176412","Phosphorylation of the APC/C",0.189542189127351,0.330144134425698,0.565886930897147,17,"ANAPC1; ANAPC10; ANAPC11; ANAPC15; ANAPC16; ANAPC2; ANAPC4; ANAPC5; ANAPC7; CCNB1; CDC16; CDC26; CDC27; CDK1; PLK1; UBE2D1; UBE2E1"
"R-HSA-168638","NOD1/2 Signaling Pathway",-0.152195782068525,0.265332616828828,0.566235978524042,27,"BIRC2; BIRC3; CARD9; CASP1; CASP4; CASP8; CASP9; CHUK; CYLD; IKBKB; IRAK2; ITCH; MAP2K6; MAP3K7; MAPK11; MAPK12; MAPK13; MAPK14; NOD1; NOD2; RIPK2; TAB1; TAB2; TNFAIP3; TRAF6; UBE2N; UBE2V1"
"R-HSA-442755","Activation of NMDA receptor and postsynaptic events",0.141316496181684,0.246495056174662,0.566439167283477,31,"ACTN2; ADCY1; ADCY3; AKAP9; BRAF; CALM1; CAMK2A; CAMK2B; CAMK2D; CAMK2G; CAMK4; CAMKK1; DLG4; GRIA1; GRIA2; GRIA4; GRIN1; GRIN2A; GRIN2B; GRIN2C; GRIN2D; HRAS; MAPK1; PDPK1; PRKACB; RAF1; RASGRF1; RASGRF2; RPS6KA1; RPS6KA2; RRAS"
"R-HSA-5654689","PI-3K cascade:FGFR1",0.200793635311618,0.350732585816913,0.566984772886338,15,"FGF1; FGF10; FGF17; FGF2; FGF20; FGF22; FGF5; FGF9; FGFR1; FRS2; GAB1; GRB2; KL; PIK3CA; PIK3R1"
"R-HSA-2122947","NOTCH1 Intracellular Domain Regulates Transcription",0.127419057225759,0.223135645201797,0.56797350567627,38,"CCNC; CDK8; CUL1; EP300; FBXW7; HDAC1; HDAC10; HDAC11; HDAC2; HDAC3; HDAC4; HDAC5; HDAC7; HDAC9; HES1; HES5; HEY1; HEY2; HEYL; HIF1A; KAT2A; KAT2B; MAML1; MAML2; MAML3; MYC; NCOR1; NOTCH1; RBPJ; SKP1; SNW1; TBL1XR1; TLE1; TLE2; TLE3; TLE4; UBA52; UBC"
"R-HSA-196791","Vitamin D (calciferol) metabolism",0.240793237924235,0.426100100345525,0.571999250084008,10,"CUBN; CYP24A1; CYP27B1; CYP2R1; GC; LGMN; PIAS4; SUMO2; UBE2I; VDR"
"R-HSA-881907","Gastrin-CREB signalling pathway via PKC and MAPK",0.211152373579586,0.375983347864456,0.574388353091929,13,"CCKBR; EGFR; GRB2; HRAS; KRAS; MAPK1; MAPK3; MMP3; NRAS; PRKCA; RPS6KA1; RPS6KA2; SOS1"
"R-HSA-8875656","MET receptor recycling",-0.2410783648521,0.429961819898486,0.57500401385104,10,"ARF6; CRK; CRKL; GAB1; GGA3; GRB2; HGF; MET; RAB4A; RAB4B"
"R-HSA-191859","snRNP Assembly",0.116798522660331,0.210091609315626,0.578251243148641,43,"CLNS1A; DDX20; GEMIN4; GEMIN5; GEMIN6; NCBP1; NCBP2; NDC1; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188; NUP205; NUP210; NUP214; NUP35; NUP43; NUP50; NUP54; NUP58; NUP62; NUP85; NUP88; NUP93; NUP98; NUPL2; PHAX; POM121; PRMT5; RAE1; RANBP2; SEH1L; SMN1; SNRPB; SNRPD1; SNRPD3; SNRPE; SNRPF; SNUPN; TGS1; WDR77"
"R-HSA-194441","Metabolism of non-coding RNA",0.116798522660331,0.210091609315626,0.578251243148641,43,"CLNS1A; DDX20; GEMIN4; GEMIN5; GEMIN6; NCBP1; NCBP2; NDC1; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188; NUP205; NUP210; NUP214; NUP35; NUP43; NUP50; NUP54; NUP58; NUP62; NUP85; NUP88; NUP93; NUP98; NUPL2; PHAX; POM121; PRMT5; RAE1; RANBP2; SEH1L; SMN1; SNRPB; SNRPD1; SNRPD3; SNRPE; SNRPF; SNUPN; TGS1; WDR77"
"R-HSA-451927","Interleukin-2 family signaling",0.131921476560739,0.239223933212707,0.581321111875151,33,"CSF2RB; GAB2; GRB2; HAVCR2; IL15; IL15RA; IL21R; IL2RA; IL2RB; IL5; INPP5D; INPPL1; JAK1; JAK2; JAK3; LGALS9; PIK3CA; PIK3CB; PIK3CD; PIK3R1; PIK3R2; PIK3R3; PTK2B; PTPN6; SHC1; SOS1; SOS2; STAT1; STAT3; STAT4; STAT5A; STAT5B; SYK"
"R-HSA-1482922","Acyl chain remodelling of PI",0.19358919060723,0.351166376818687,0.581445278490578,15,"MBOAT7; PLA2G10; PLA2G12A; PLA2G16; PLA2G1B; PLA2G2A; PLA2G2D; PLA2G4A; PLA2G4C; PLA2G4D; PLA2G4E; PLA2G4F; PLA2G5; PLA2R1; PLBD1"
"R-HSA-175474","Assembly Of The HIV Virion",-0.200060384146913,0.365956268246198,0.584599702029783,14,"FURIN; MVB12A; MVB12B; NMT2; PPIA; TSG101; UBA52; UBAP1; UBC; VPS28; VPS37A; VPS37B; VPS37C; VPS37D"
"R-HSA-110313","Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template",-0.131309759007258,0.240568015400985,0.585181315838241,33,"ISG15; MAD2L2; NPLOC4; PCLAF; PCNA; POLD1; POLD2; POLD3; POLE; POLE2; POLE3; POLE4; POLI; POLK; RCHY1; REV1; REV3L; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3; SPRTN; TRIM25; UBA52; UBA7; UBC; UBE2L6; USP10; VCP"
"R-HSA-8951671","RUNX3 regulates YAP1-mediated transcription",-0.176756124744532,0.323851731671831,0.585207988130731,18,"CARM1; CHD9; CTGF; NCOA1; NCOA2; NCOA6; PPARA; RUNX3; RXRA; SMARCD3; TBL1XR1; TEAD1; TEAD2; TEAD3; TEAD4; TGS1; WWTR1; YAP1"
"R-HSA-171306","Packaging Of Telomere Ends",0.185817942954103,0.34048335026606,0.585239504240533,16,"ACD; H2AFJ; H2AFV; H2AFX; H2AFZ; H2BFS; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HIST2H2AA3; HIST2H2AC; POT1; TERF1; TERF2; TERF2IP"
"R-HSA-168254","Influenza Infection",0.102211884634831,0.187896545110798,0.586455521345448,54,"CALR; CANX; CLTA; CLTC; CPSF4; DNAJC3; EIF2AK2; FAU; GRSF1; GTF2F1; GTF2F2; HSP90AA1; IPO5; ISG15; KPNA1; KPNA2; KPNA3; KPNA4; KPNA5; KPNA7; KPNB1; NDC1; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188; NUP205; NUP210; NUP214; NUP35; NUP43; NUP50; NUP54; NUP58; NUP62; NUP85; NUP88; NUP93; NUP98; NUPL2; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; POM121"
"R-HSA-186763","Downstream signal transduction",0.143479629141681,0.263965378230198,0.586747921117893,27,"BCAR1; CRK; CRKL; GRB2; GRB7; HRAS; KRAS; NCK1; NCK2; NRAS; PDGFB; PDGFRA; PDGFRB; PIK3CA; PIK3CB; PIK3R1; PIK3R2; PLCG1; RAPGEF1; RASA1; SOS1; SRC; STAT1; STAT3; STAT5A; STAT5B; STAT6"
"R-HSA-429914","Deadenylation-dependent mRNA decay",0.107860973573338,0.199108884865674,0.588012418609068,48,"CNOT1; CNOT11; CNOT2; CNOT3; CNOT4; CNOT6; CNOT6L; CNOT7; CNOT8; DCP2; DCPS; DDX6; DIS3; EIF4A1; EIF4A2; EIF4A3; EIF4B; EIF4E; EIF4G1; EXOSC1; EXOSC2; EXOSC3; EXOSC4; EXOSC5; EXOSC6; EXOSC7; EXOSC8; EXOSC9; HBS1L; LSM2; LSM4; LSM5; LSM6; LSM7; NT5C3B; PABPC1; PAIP1; PAN2; PAN3; PARN; PATL1; SKIV2L; TNKS1BP1; TTC37; WDR61; XRN1; ZCCHC11; ZCCHC6"
"R-HSA-5655332","Signaling by FGFR3 in disease",0.173738079133523,0.321678778265817,0.58912941912925,18,"FGF1; FGF17; FGF18; FGF2; FGF20; FGF5; FGF9; FGFR3; FRS2; GAB1; GRB2; HRAS; KRAS; NRAS; PIK3CA; PIK3R1; PLCG1; SOS1"
"R-HSA-8853338","Signaling by FGFR3 point mutants in cancer",0.173738079133523,0.321678778265817,0.58912941912925,18,"FGF1; FGF17; FGF18; FGF2; FGF20; FGF5; FGF9; FGFR3; FRS2; GAB1; GRB2; HRAS; KRAS; NRAS; PIK3CA; PIK3R1; PLCG1; SOS1"
"R-HSA-72689","Formation of a pool of free 40S subunits",-0.100880521886806,0.187021238367377,0.589606211528971,55,"EIF3A; EIF3B; EIF3C; EIF3D; EIF3E; EIF3F; EIF3G; EIF3H; EIF3I; EIF3J; EIF3K; EIF3L; EIF3M; FAU; RPL10A; RPL12; RPL13; RPL13A; RPL14; RPL15; RPL17; RPL18; RPL18A; RPL19; RPL21; RPL22L1; RPL23A; RPL26; RPL26L1; RPL27A; RPL28; RPL29; RPL3; RPL30; RPL31; RPL32; RPL34; RPL35; RPL35A; RPL36; RPL36AL; RPL37; RPL38; RPL39L; RPL3L; RPL4; RPL41; RPL5; RPL7; RPL7A; RPL8; RPL9; RPLP0; RPLP2; RPS10"
"R-HSA-73863","RNA Polymerase I Transcription Termination",0.142332669902418,0.264004396483227,0.589797209881494,27,"CCNH; CDK7; ERCC3; GTF2H1; GTF2H2; GTF2H3; GTF2H4; GTF2H5; MNAT1; POLR1A; POLR1B; POLR1C; POLR1D; POLR1E; POLR2E; POLR2F; POLR2H; POLR2K; POLR2L; TAF1A; TAF1B; TAF1C; TAF1D; TBP; TTF1; TWISTNB; ZNRD1"
"R-HSA-8853334","Signaling by FGFR3 fusions in cancer",0.230071160457399,0.427023789697208,0.590039823983264,10,"FGFR3; FRS2; GAB1; GRB2; HRAS; KRAS; NRAS; PIK3CA; PIK3R1; SOS1"
"R-HSA-352230","Amino acid transport across the plasma membrane",-0.14637534984844,0.27585168118371,0.595674769581059,25,"SLC16A10; SLC1A4; SLC1A5; SLC25A29; SLC36A1; SLC36A2; SLC36A4; SLC38A1; SLC38A4; SLC3A1; SLC43A1; SLC43A2; SLC6A12; SLC6A15; SLC6A19; SLC6A6; SLC7A1; SLC7A10; SLC7A11; SLC7A2; SLC7A5; SLC7A6; SLC7A7; SLC7A8; SLC7A9"
"R-HSA-197264","Nicotinamide salvaging",-0.171181278373434,0.324067168963354,0.597341256452209,18,"CYP8B1; NAMPT; NAPRT; NAXD; NAXE; NNMT; NUDT12; PARP10; PARP14; PARP16; PARP4; PARP6; PARP8; PARP9; PTGIS; PTGS2; RNLS; SLC5A8"
"R-HSA-6806667","Metabolism of fat-soluble vitamins",0.119231753559445,0.226323040590182,0.598317827754382,37,"AGRN; AKR1B10; AKR1C1; AKR1C3; APOA1; APOA2; APOB; APOC3; APOM; BCO1; BCO2; CLPS; GPC1; GPC2; GPC5; GPC6; HSPG2; LDLR; LPL; LRAT; LRP1; LRP12; LRP8; PLB1; RBP1; RBP4; RDH11; RETSAT; SDC1; SDC2; SDC3; SDC4; TTPA; TTR; UBIAD1; VKORC1; VKORC1L1"
"R-HSA-2644602","Signaling by NOTCH1 PEST Domain Mutants in Cancer",0.105634695028817,0.201245642897714,0.599649748663949,47,"ADAM10; ADAM17; APH1A; APH1B; CCNC; CDK8; CUL1; DLL1; EP300; FBXW7; HDAC1; HDAC10; HDAC11; HDAC2; HDAC3; HDAC4; HDAC5; HDAC7; HDAC9; HES1; HES5; HEY1; HEY2; HEYL; JAG1; JAG2; KAT2A; KAT2B; MAML1; MAML2; MAML3; MIB1; MIB2; MYC; NCOR1; NCSTN; NEURL1; NEURL1B; NOTCH1; PSEN1; PSEN2; RBPJ; SKP1; SNW1; TBL1XR1; UBA52; UBC"
"R-HSA-2644603","Signaling by NOTCH1 in Cancer",0.105634695028817,0.201245642897714,0.599649748663949,47,"ADAM10; ADAM17; APH1A; APH1B; CCNC; CDK8; CUL1; DLL1; EP300; FBXW7; HDAC1; HDAC10; HDAC11; HDAC2; HDAC3; HDAC4; HDAC5; HDAC7; HDAC9; HES1; HES5; HEY1; HEY2; HEYL; JAG1; JAG2; KAT2A; KAT2B; MAML1; MAML2; MAML3; MIB1; MIB2; MYC; NCOR1; NCSTN; NEURL1; NEURL1B; NOTCH1; PSEN1; PSEN2; RBPJ; SKP1; SNW1; TBL1XR1; UBA52; UBC"
"R-HSA-2644606","Constitutive Signaling by NOTCH1 PEST Domain Mutants",0.105634695028817,0.201245642897714,0.599649748663949,47,"ADAM10; ADAM17; APH1A; APH1B; CCNC; CDK8; CUL1; DLL1; EP300; FBXW7; HDAC1; HDAC10; HDAC11; HDAC2; HDAC3; HDAC4; HDAC5; HDAC7; HDAC9; HES1; HES5; HEY1; HEY2; HEYL; JAG1; JAG2; KAT2A; KAT2B; MAML1; MAML2; MAML3; MIB1; MIB2; MYC; NCOR1; NCSTN; NEURL1; NEURL1B; NOTCH1; PSEN1; PSEN2; RBPJ; SKP1; SNW1; TBL1XR1; UBA52; UBC"
"R-HSA-2894858","Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer",0.105634695028817,0.201245642897714,0.599649748663949,47,"ADAM10; ADAM17; APH1A; APH1B; CCNC; CDK8; CUL1; DLL1; EP300; FBXW7; HDAC1; HDAC10; HDAC11; HDAC2; HDAC3; HDAC4; HDAC5; HDAC7; HDAC9; HES1; HES5; HEY1; HEY2; HEYL; JAG1; JAG2; KAT2A; KAT2B; MAML1; MAML2; MAML3; MIB1; MIB2; MYC; NCOR1; NCSTN; NEURL1; NEURL1B; NOTCH1; PSEN1; PSEN2; RBPJ; SKP1; SNW1; TBL1XR1; UBA52; UBC"
"R-HSA-2894862","Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants",0.105634695028817,0.201245642897714,0.599649748663949,47,"ADAM10; ADAM17; APH1A; APH1B; CCNC; CDK8; CUL1; DLL1; EP300; FBXW7; HDAC1; HDAC10; HDAC11; HDAC2; HDAC3; HDAC4; HDAC5; HDAC7; HDAC9; HES1; HES5; HEY1; HEY2; HEYL; JAG1; JAG2; KAT2A; KAT2B; MAML1; MAML2; MAML3; MIB1; MIB2; MYC; NCOR1; NCSTN; NEURL1; NEURL1B; NOTCH1; PSEN1; PSEN2; RBPJ; SKP1; SNW1; TBL1XR1; UBA52; UBC"
"R-HSA-76061","RNA Polymerase III Transcription Initiation From Type 1 Promoter",0.137504772937976,0.264165875852451,0.602698155246216,27,"BDP1; BRF1; CRCP; GTF3A; GTF3C1; GTF3C2; GTF3C3; GTF3C4; GTF3C5; GTF3C6; POLR1C; POLR1D; POLR2E; POLR2F; POLR2H; POLR2K; POLR2L; POLR3A; POLR3B; POLR3C; POLR3D; POLR3F; POLR3G; POLR3GL; POLR3H; POLR3K; TBP"
"R-HSA-392851","Prostacyclin signalling through prostacyclin receptor",0.177179047001474,0.340952825452151,0.603301589711468,16,"GNAS; GNB1; GNB2; GNB3; GNB4; GNB5; GNG10; GNG11; GNG12; GNG2; GNG3; GNG4; GNG5; GNG7; GNGT2; PTGIR"
"R-HSA-449147","Signaling by Interleukins",0.0967240586441092,0.186292054717593,0.603616698351069,55,"AGER; AIP; AKT1; ALOX15; ALOX5; ANXA1; ANXA2; APP; ATF1; ATF2; BATF; BCL2; BCL2L1; BIRC5; BLNK; BOLA2; BRWD1; BTRC; CA1; CANX; CAPZA1; CASP1; CASP3; CBL; CCL11; CCL19; CCL2; CCL20; CCL22; CCND1; CCR1; CCR2; CCR5; CD36; CD4; CD80; CD86; CDC42; CFL1; CHUK; CISH; CLCF1; CNN2; CNTF; CNTFR; COL1A2; CRK; CRKL; CRLF1; CSF1; CSF1R; CSF2RB; CSF3; CSF3R; CTF1"
"R-HSA-5654708","Downstream signaling of activated FGFR3",0.158770977440964,0.305873336346289,0.603708953316716,20,"FGF1; FGF17; FGF18; FGF2; FGF20; FGF5; FGF9; FGFR3; FRS2; FRS3; GAB1; GRB2; HRAS; KRAS; NRAS; PIK3CA; PIK3R1; PLCG1; SHC1; SOS1"
"R-HSA-8953750","Transcriptional Regulation by E2F6",-0.130897896711195,0.252259977414433,0.603829940268423,30,"APAF1; BMI1; BRCA1; CBX3; CBX5; CDC7; CHEK1; E2F1; E2F6; EED; EHMT1; EHMT2; EPC1; EZH2; L3MBTL2; MAX; MGA; PCGF6; PHC1; PHC3; RAD51; RBBP4; RBBP8; RING1; RNF2; RRM2; RYBP; SUZ12; TFDP1; YAF2"
"R-HSA-69618","Mitotic Spindle Checkpoint",-0.0959576558930358,0.185406766866927,0.604770830657447,56,"AHCTF1; ANAPC1; ANAPC10; ANAPC11; ANAPC15; ANAPC16; ANAPC2; ANAPC4; ANAPC5; ANAPC7; AURKB; B9D2; BIRC5; BUB1B; BUB3; CDC16; CDC26; CDC27; CENPA; CENPC; CENPE; CENPF; CENPH; CENPK; CENPL; CENPM; CENPN; CENPO; CENPP; CENPQ; CENPT; CENPU; CKAP5; CLASP1; CLIP1; DSN1; DYNC1H1; DYNC1I1; DYNC1I2; DYNC1LI1; DYNC1LI2; DYNLL1; DYNLL2; INCENP; ITGB3BP; KIF2A; KIF2C; KNTC1; MAD1L1; MAD2L1; MAPRE1; MIS12; NDE1; NDEL1; NSL1; NUDC"
"R-HSA-4641262","Disassembly of the destruction complex and recruitment of AXIN to the membrane",0.136615368214434,0.264195136862972,0.605086187323873,27,"APC; AXIN1; CAV1; CSNK1A1; CSNK1G2; CTNNB1; DVL1; DVL2; DVL3; FRAT1; FRAT2; FZD1; FZD2; FZD5; GSK3B; LRP5; LRP6; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5A; PPP2R5B; PPP2R5C; PPP2R5D; PPP2R5E; WNT8B"
"R-HSA-5693568","Resolution of D-loop Structures through Holliday Junction Intermediates",0.125697855442287,0.243092236310292,0.605101112968748,32,"ATM; BARD1; BLM; BRCA1; BRCA2; BRIP1; DNA2; EME1; EME2; EXO1; GEN1; KAT5; MRE11; MUS81; NBN; PALB2; RAD50; RAD51; RAD51AP1; RAD51B; RAD51C; RAD51D; RBBP8; RMI1; RMI2; SLX1A; SLX4; SPIDR; TOP3A; WRN; XRCC2; XRCC3"
"R-HSA-2408557","Selenocysteine synthesis",0.0955391060170858,0.186312275033915,0.608098096053484,55,"EEFSEC; FAU; PSTK; RPL10A; RPL12; RPL13; RPL13A; RPL14; RPL15; RPL17; RPL18; RPL18A; RPL19; RPL21; RPL22L1; RPL23A; RPL26; RPL26L1; RPL27A; RPL28; RPL29; RPL3; RPL30; RPL31; RPL32; RPL34; RPL35; RPL35A; RPL36; RPL36AL; RPL37; RPL38; RPL39L; RPL3L; RPL4; RPL41; RPL5; RPL7; RPL7A; RPL8; RPL9; RPLP0; RPLP2; RPS10; RPS11; RPS12; RPS13; RPS14; RPS15; RPS15A; RPS16; RPS18; RPS19; RPS2; RPS20"
"R-HSA-190242","FGFR1 ligand binding and activation",0.219424467596307,0.427905511531715,0.608100186941819,10,"FGF1; FGF10; FGF17; FGF2; FGF20; FGF22; FGF5; FGF9; FGFR1; KL"
"R-HSA-937072","TRAF6-mediated induction of TAK1 complex within TLR4 complex",0.186263570804042,0.363902773110576,0.608756116167475,14,"CD14; IRAK2; LY96; MAP3K7; SARM1; TAB1; TAB2; TICAM1; TICAM2; TLR3; TLR4; TRAF6; UBA52; UBC"
"R-HSA-8851680","Butyrophilin (BTN) family interactions",-0.201139923971777,0.395145997924619,0.610733401573815,12,"BTN1A1; BTN2A1; BTN2A2; BTN3A1; BTN3A2; BTN3A3; BTNL2; BTNL8; BTNL9; CD209; PPL; XDH"
"R-HSA-3214842","HDMs demethylate histones",0.163893612012316,0.322152832610715,0.610931042670195,18,"ARID5B; JMJD6; KDM1A; KDM1B; KDM2A; KDM2B; KDM3A; KDM3B; KDM4A; KDM4B; KDM4C; KDM4D; KDM5A; KDM5B; KDM6B; KDM7A; KDM8; PHF2"
"R-HSA-196299","Beta-catenin phosphorylation cascade",0.17316426833867,0.341164683726822,0.611756353031598,16,"APC; AXIN1; CSNK1A1; CTNNB1; FRAT1; FRAT2; GSK3B; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5A; PPP2R5B; PPP2R5C; PPP2R5D; PPP2R5E"
"R-HSA-201451","Signaling by BMP",0.147595002742532,0.29214416338685,0.613409304189354,22,"ACVR2A; ACVR2B; ACVRL1; AMH; AMHR2; BMPR1A; BMPR1B; BMPR2; CER1; FSTL1; GREM2; NOG; SKI; SMAD1; SMAD4; SMAD5; SMAD9; SMURF1; SMURF2; UBE2D1; UBE2D3; ZFYVE16"
"R-HSA-6802948","Signaling by high-kinase activity BRAF mutants",0.122497792876761,0.24318119128455,0.614450744068152,32,"APBB1IP; ARRB1; ARRB2; BRAF; CNKSR1; CSK; FGA; FGB; FGG; FN1; HRAS; IQGAP1; ITGA2B; ITGB3; KRAS; KSR1; KSR2; MAP2K1; MAP2K2; MAPK1; MAPK3; MARK3; NRAS; PEBP1; RAF1; RAP1A; RAP1B; SRC; TLN1; VCL; VWF; YWHAB"
"R-HSA-112314","Neurotransmitter receptors and postsynaptic signal transmission",-0.093308073310784,0.185431088908108,0.61482688969586,56,"ACTN2; ADCY1; ADCY2; ADCY3; ADCY4; ADCY5; ADCY6; ADCY7; ADCY9; AKAP9; AP2A1; AP2A2; AP2B1; AP2M1; AP2S1; BRAF; CACNG3; CACNG4; CACNG8; CALM1; CAMK2A; CAMK2B; CAMK2D; CAMK2G; CAMK4; CAMKK1; CHRNA1; CHRNA2; CHRNA3; CHRNA4; CHRNA5; CHRNA6; CHRNA7; CHRNB2; CHRNB3; CHRNB4; CHRND; CHRNE; CHRNG; DLG1; DLG4; EPB41L1; GABBR1; GABBR2; GABRA2; GABRA4; GABRA5; GABRA6; GABRB1; GABRB2; GABRB3; GABRG2; GABRG3; GABRR1; GABRR2; GLRA1"
"R-HSA-428540","Activation of RAC1",-0.198853570653436,0.395275803701185,0.614911194659344,12,"NCK1; NCK2; PAK1; PAK2; PAK4; PAK5; PAK6; RAC1; ROBO1; SLIT2; SOS1; SOS2"
"R-HSA-445717","Aquaporin-mediated transport",0.106787794654236,0.212783700465528,0.615765452757786,42,"ADCY1; ADCY2; ADCY3; ADCY4; ADCY5; ADCY6; ADCY7; ADCY9; AQP1; AQP10; AQP11; AQP12A; AQP3; AQP4; AQP5; AQP6; AQP7; AQP8; AQP9; GNAS; GNB1; GNB2; GNB3; GNB4; GNB5; GNG10; GNG11; GNG12; GNG2; GNG3; GNG4; GNG5; GNG7; GNGT2; MYO5B; PRKACB; PRKAR1A; PRKAR1B; PRKAR2A; PRKAR2B; RAB11A; RAB11FIP2"
"R-HSA-5576892","Phase 0 - rapid depolarisation",-0.109275714909916,0.218967368257291,0.617744000210318,40,"CACNA1C; CACNA1D; CACNA1S; CACNA2D1; CACNA2D2; CACNA2D3; CACNA2D4; CACNB1; CACNB2; CACNB3; CACNB4; CACNG1; CACNG3; CACNG4; CACNG5; CACNG6; CACNG8; CALM1; CAMK2A; CAMK2B; CAMK2D; CAMK2G; FGF11; FGF12; FGF14; RANGRF; SCN10A; SCN11A; SCN1A; SCN1B; SCN2A; SCN2B; SCN3A; SCN3B; SCN4A; SCN4B; SCN5A; SCN7A; SCN8A; SCN9A"
"R-HSA-8876384","Listeria monocytogenes entry into host cells",0.164903405415774,0.331416284122118,0.618785866342323,17,"CBL; CBLL1; CDH1; CTNNB1; CTNND1; EPS15; GRB2; HGS; MET; SH3GL1; SH3GL2; SH3GL3; SRC; STAM; STAM2; UBA52; UBC"
"R-HSA-1483206","Glycerophospholipid biosynthesis",0.0871837566953742,0.175705521623782,0.619758623456126,62,"ABHD3; ABHD4; ACHE; ACP6; AGK; AGPAT1; AGPAT2; AGPAT3; AGPAT4; AGPAT5; BCHE; CDIPT; CDS1; CDS2; CEPT1; CHKA; CHKB; CHPT1; CPNE1; CPNE3; CPNE6; CPNE7; CRLS1; CSNK2A2; CSNK2B; DDHD1; DDHD2; DGAT1; DGAT2; ETNK1; ETNK2; ETNPPL; GNPAT; GPAM; GPAT2; GPAT3; GPAT4; GPCPD1; GPD1; GPD1L; GPD2; HADHA; HADHB; HRASLS; HRASLS2; HRASLS5; LCLAT1; LIPH; LIPI; LPCAT1; LPCAT2; LPCAT3; LPCAT4; LPGAT1; LPIN1; LPIN2; LPIN3; MBOAT1; MBOAT2; MBOAT7; MFSD2A; MGLL"
"R-HSA-164938","Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters",0.159514569729536,0.322356380693646,0.620713639569675,18,"AP1B1; AP1G1; AP1M1; AP1M2; AP1S1; AP1S3; AP2A1; AP2A2; AP2B1; AP2M1; AP2S1; ATP6V1H; B2M; CD28; CD4; CD8B; HLA-A; PACS1"
"R-HSA-391903","Eicosanoid ligand-binding receptors",-0.181534999042877,0.36687227537508,0.620728609782536,14,"CYSLTR2; GPR17; LTB4R; LTB4R2; OXER1; PTGDR; PTGDR2; PTGER1; PTGER2; PTGER3; PTGER4; PTGFR; PTGIR; TBXA2R"
"R-HSA-2980736","Peptide hormone metabolism",0.0962416762722786,0.195310318738464,0.622180137842844,50,"ACE; ACHE; AGT; ANPEP; BCHE; CDX2; CGA; CGB3; CMA1; CPA3; CPE; CRHR2; CTNNB1; CTSD; CTSG; CTSZ; DPP4; ENPEP; ERO1A; ERO1B; EXOC1; EXOC2; EXOC3; EXOC4; EXOC5; EXOC6; EXOC7; FFAR1; FFAR4; GCG; GHRL; GNAT3; GNB3; GRP; IGF1; INHA; INHBA; INHBB; INHBE; KIF5A; KIF5B; KIF5C; LHB; MBOAT4; MME; MYO5A; MYRIP; PAX6; PCSK1; PCSK2"
"R-HSA-76046","RNA Polymerase III Transcription Initiation",0.114703243112118,0.232778691108147,0.622184559317028,35,"BDP1; BRF1; BRF2; CRCP; GTF3A; GTF3C1; GTF3C2; GTF3C3; GTF3C4; GTF3C5; GTF3C6; POLR1C; POLR1D; POLR2E; POLR2F; POLR2H; POLR2K; POLR2L; POLR3A; POLR3B; POLR3C; POLR3D; POLR3F; POLR3G; POLR3GL; POLR3H; POLR3K; POU2F1; SNAPC1; SNAPC2; SNAPC3; SNAPC4; SNAPC5; TBP; ZNF143"
"R-HSA-168928","DDX58/IFIH1-mediated induction of interferon-alpha/beta",-0.101806837548267,0.206611798904678,0.622193096227654,45,"AGER; APP; ATG12; ATG5; CASP10; CASP8; CHUK; CYLD; DDX58; DHX36; DHX58; EP300; FADD; IFIH1; IKBKB; IRF1; IRF3; IRF7; ISG15; ITCH; MAP3K1; MAVS; MYD88; NFKB1; NFKB2; NFKBIA; NFKBIB; NKIRAS1; NLRC5; NLRX1; PCBP2; PIN1; RELA; RIPK1; RNF125; RNF135; RNF216; S100A12; S100B; SAA1; SIKE1; TANK; TAX1BP1; TBK1; TKFC"
"R-HSA-389948","PD-1 signaling",0.158776349288926,0.322390249954652,0.622367782734558,18,"CD247; CD274; CD3D; CD3E; CD4; CSK; HLA-DPA1; HLA-DPB1; HLA-DQA1; HLA-DQA2; HLA-DQB1; HLA-DQB2; HLA-DRA; HLA-DRB1; HLA-DRB5; PDCD1; PDCD1LG2; PTPN6"
"R-HSA-399954","Sema3A PAK dependent Axon repulsion",0.178855496007782,0.364336187011812,0.62349162124344,14,"CFL1; FES; FYN; HSP90AA1; HSP90AB1; LIMK1; NRP1; PAK1; PAK2; PLXNA1; PLXNA2; PLXNA4; RAC1; SEMA3A"
"R-HSA-5668914","Diseases of metabolism",-0.113123960259721,0.230686389933251,0.623865123496259,36,"AMN; CD320; CSF2RB; CUBN; CYP11A1; EPM2A; FDX1; FDX2; FDXR; GIF; GYG1; GYS1; GYS2; MC2R; MCCC1; MCCC2; MMAA; MMACHC; MMADHC; MTR; MTRR; MUT; PC; PCCA; PCCB; POMC; PPP1R3C; SFTPA1; SFTPA2; SFTPB; SFTPC; SFTPD; TCN2; TTF1; UBA52; UBC"
"R-HSA-419408","Lysosphingolipid and LPA receptors",0.177788088362395,0.364397429893534,0.625623430347404,14,"LPAR1; LPAR2; LPAR3; LPAR5; PLPPR1; PLPPR2; PLPPR3; PLPPR4; PLPPR5; S1PR1; S1PR2; S1PR3; S1PR4; S1PR5"
"R-HSA-449836","Other interleukin signaling",-0.137260907288029,0.281749485321897,0.626135321826447,24,"CASP3; CD4; CSF1; CSF1R; CSF3; CSF3R; FLT3; IFNLR1; IL10RB; IL16; IL32; IL34; JAK1; PRTN3; PTPRZ1; SDC1; SNAP25; STX1A; STX3; STX4; STXBP2; TXLNA; TYK2; VAMP2"
"R-HSA-169893","Prolonged ERK activation events",0.199398035925467,0.409519708248132,0.626324197660945,11,"BRAF; CRK; CRKL; FRS2; KIDINS220; NGF; NTRK1; PLCG1; RAP1A; RAPGEF1; YWHAB"
"R-HSA-3371497","HSP90 chaperone cycle for steroid hormone receptors (SHR)",0.120186780186735,0.247117479591342,0.626715609375121,31,"ACTR10; ACTR1A; CAPZA1; CAPZA2; CAPZA3; CAPZB; DCTN1; DCTN2; DCTN4; DCTN5; DCTN6; DNAJA1; DNAJA2; DNAJA4; DNAJB1; DYNC1H1; DYNC1I1; DYNC1I2; DYNC1LI1; DYNC1LI2; DYNLL1; DYNLL2; FKBP4; HSP90AA1; HSP90AB1; HSPA1B; HSPA1L; HSPA2; HSPA8; NR3C1; PGR"
"R-HSA-177929","Signaling by EGFR",0.106515929905302,0.223641855682531,0.633875590757325,38,"ADAM10; ADAM12; ADAM17; ARHGEF7; CBL; CDC42; CSK; EGF; EGFR; EPN1; EPS15; EPS15L1; GAB1; GRB2; HGS; HRAS; KRAS; LRIG1; NRAS; PAG1; PIK3CA; PIK3R1; PLCG1; PTPN12; PTPN3; PTPRK; PXN; SH3GL1; SH3GL2; SH3GL3; SHC1; SOS1; SPRY1; SRC; STAM; STAM2; UBA52; UBC"
"R-HSA-2022928","HS-GAG biosynthesis",0.12790247098149,0.269490227646527,0.63506573374862,26,"AGRN; EXT1; EXT2; GLCE; GPC1; GPC2; GPC5; GPC6; HS2ST1; HS3ST1; HS3ST2; HS3ST3A1; HS3ST3B1; HS3ST6; HS6ST1; HS6ST3; HSPG2; NDST1; NDST2; NDST3; NDST4; SDC1; SDC2; SDC3; SDC4; SLC35D2"
"R-HSA-5689896","Ovarian tumor domain proteases",-0.119505224612985,0.252479533667154,0.635980341761205,30,"APC; CDK1; DDX58; ESR1; IFIH1; MAVS; NOD1; NOD2; OTUB1; OTUB2; OTUD3; OTUD7A; PTEN; RIPK1; RIPK2; RNF135; TNFAIP3; TNIP1; TNIP2; TNIP3; TRAF3; TRAF6; TRIM25; UBA52; UBC; UBE2D1; VCP; VCPIP1; YOD1; ZRANB1"
"R-HSA-3000157","Laminin interactions",0.135439821391884,0.286194686743338,0.636039351308691,23,"COL18A1; HSPG2; ITGA1; ITGA2; ITGA3; ITGA6; ITGA7; ITGAV; ITGB1; ITGB4; LAMA1; LAMA2; LAMA3; LAMA4; LAMA5; LAMB1; LAMB2; LAMB3; LAMC1; LAMC2; LAMC3; NID1; NID2"
"R-HSA-2424491","DAP12 signaling",-0.128163910050159,0.27094526186577,0.636195270706035,26,"B2M; FYN; GRAP2; GRB2; HLA-E; HRAS; KLRC2; KLRD1; KLRK1; KRAS; LAT; LCP2; NRAS; PIK3CA; PIK3CB; PIK3R1; PIK3R2; PLCG1; PLCG2; RAC1; SHC1; SOS1; SYK; TREM2; VAV2; VAV3"
"R-HSA-1980150","Signaling by NOTCH4",-0.2042438469574,0.43258401963609,0.636820877186358,10,"ADAM10; APH1A; APH1B; DLL1; JAG1; JAG2; NCSTN; NOTCH4; PSEN1; PSEN2"
"R-HSA-5620922","BBSome-mediated cargo-targeting to cilium",0.14701553180278,0.31429214266576,0.639951133025582,19,"BBIP1; BBS1; BBS10; BBS12; BBS2; BBS4; BBS5; BBS7; BBS9; CCT2; CCT3; CCT4; CCT5; CCT8; MCHR1; MKKS; RAB3IP; TCP1; TTC8"
"R-HSA-2022857","Keratan sulfate degradation",-0.183749738958737,0.396087544382674,0.642710841895733,12,"ACAN; FMOD; GLB1; GLB1L; GNS; HEXA; HEXB; KERA; LUM; OGN; OMD; PRELP"
"R-HSA-68875","Mitotic Prophase",0.0923703114359403,0.199402526140714,0.643195635614804,48,"ARPP19; BANF1; BLZF1; CCNB1; CCNB2; CDK1; CNEP1R1; CTDNEP1; ENSA; GOLGA2; GORASP1; GORASP2; H2AFJ; H2AFV; H2AFX; H2AFZ; H2BFS; H3F3A; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HIST2H2AA3; HIST2H2AC; KMT5A; LEMD2; LEMD3; LMNA; LMNB1; LPIN1; LPIN2; LPIN3; MAPK1; MAPK3; MASTL; MCPH1; NCAPD3; NCAPG2; NCAPH2; NDC1; NEK6; NEK7; NEK9; NUMA1; NUP107; NUP133; NUP153; NUP155"
"R-HSA-109582","Hemostasis",0.0811624104684478,0.175792803756652,0.644301069252147,62,"A1BG; A2M; ABCC4; ABHD12; ABHD6; ABL1; ACTN1; ACTN2; ACTN4; ADRA2A; ADRA2C; AK3; AKAP1; AKAP10; AKT1; AKT2; AKT3; ALB; ANGPT1; ANGPT2; ANGPT4; ANXA2; ANXA5; APBB1IP; APLP2; APOA1; APOB; APOH; APP; ARRB1; ARRB2; ATP1B1; ATP1B2; ATP1B3; ATP2A1; ATP2A2; ATP2A3; ATP2B1; ATP2B2; ATP2B4; BCAR1; BRPF3; BSG; C1QBP; CABLES1; CABLES2; CALM1; CALU; CAP1; CAPZA1; CAPZA2; CAPZB; CARMIL1; CAV1; CBX5; CD109; CD2; CD244; CD36; CD44; CD47; CD48"
"R-HSA-429958","mRNA decay by 3' to 5' exoribonuclease",0.157526991273504,0.341951474876632,0.645034950753027,16,"DCPS; DIS3; EXOSC1; EXOSC2; EXOSC3; EXOSC4; EXOSC5; EXOSC6; EXOSC7; EXOSC8; EXOSC9; HBS1L; NT5C3B; SKIV2L; TTC37; WDR61"
"R-HSA-438064","Post NMDA receptor activation events",0.119183187238547,0.259987857174803,0.646651958482969,28,"ACTN2; ADCY1; ADCY3; AKAP9; BRAF; CALM1; CAMK2A; CAMK2B; CAMK2D; CAMK2G; CAMK4; CAMKK1; DLG4; GRIN1; GRIN2A; GRIN2B; GRIN2C; GRIN2D; HRAS; MAPK1; PDPK1; PRKACB; RAF1; RASGRF1; RASGRF2; RPS6KA1; RPS6KA2; RRAS"
"R-HSA-442982","Ras activation upon Ca2+ influx through NMDA receptor",0.156348225900052,0.342008302361398,0.647565061191807,16,"ACTN2; AKAP9; CALM1; CAMK2A; CAMK2B; CAMK2D; CAMK2G; DLG4; GRIN1; GRIN2A; GRIN2B; GRIN2C; GRIN2D; HRAS; RASGRF1; RASGRF2"
"R-HSA-373080","Class B/2 (Secretin family receptors)",0.0867357767954778,0.189910934594662,0.6478736204447,53,"ADCYAP1; ADCYAP1R1; ADGRE1; ADGRE2; ADM; ADM2; CALCA; CALCB; CALCRL; CD55; CRHBP; CRHR1; CRHR2; DHH; FZD1; FZD10; FZD2; FZD3; FZD4; FZD5; FZD6; FZD7; FZD8; FZD9; GCG; GLP1R; GLP2R; GNAS; GNB1; GNB2; GNB3; GNB4; GNB5; GNG10; GNG11; GNG12; GNG2; GNG3; GNG4; GNG5; GNG7; GNGT2; IHH; PTCH1; PTCH2; PTH1R; PTH2R; PTHLH; RAMP1; RAMP2; RAMP3; SCT; SCTR"
"R-HSA-5625900","RHO GTPases activate CIT",-0.148272572901475,0.324862386239097,0.648090459501917,18,"CDKN1B; CIT; DLG4; KIF14; MYH10; MYH11; MYH14; MYH9; MYL12B; MYL6; MYL9; PPP1CB; PPP1R12A; PPP1R12B; PRC1; RAC1; RHOB; RHOC"
"R-HSA-2028269","Signaling by Hippo",0.147304012890798,0.322900061921349,0.64825283547384,18,"AMOTL2; CASP3; DVL2; LATS1; LATS2; MOB1A; MOB1B; NPHP4; SAV1; STK3; STK4; TJP1; TJP2; WWC1; WWTR1; YAP1; YWHAB; YWHAE"
"R-HSA-168138","Toll Like Receptor 9 (TLR9) Cascade",0.0823040324204989,0.181680792667475,0.650538304504124,58,"AGER; APP; ATF1; ATF2; BTRC; CD14; CHUK; CUL1; DHX36; DUSP3; DUSP4; DUSP7; ECSIT; EEA1; FBXW11; FOS; IKBKB; IRAK2; IRAK4; IRF7; LY96; MAP2K1; MAP2K3; MAP2K4; MAP2K6; MAP2K7; MAP3K1; MAP3K7; MAP3K8; MAPK1; MAPK10; MAPK11; MAPK14; MAPK3; MAPK8; MAPK9; MAPKAPK2; MAPKAPK3; MEF2A; MEF2C; MYD88; NFKB1; NFKB2; NFKBIA; NFKBIB; NKIRAS1; NOD1; NOD2; PELI1; PELI2; PELI3; PIK3C3; PIK3R4; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5D"
"R-HSA-977443","GABA receptor activation",-0.0924174360530928,0.204468969323138,0.651277924865389,46,"ADCY1; ADCY2; ADCY3; ADCY4; ADCY5; ADCY6; ADCY7; ADCY9; GABBR1; GABBR2; GABRA2; GABRA4; GABRA5; GABRA6; GABRB1; GABRB2; GABRB3; GABRG2; GABRG3; GABRR1; GABRR2; GNAI1; GNAI2; GNAI3; GNAL; GNAT3; GNB1; GNB2; GNB3; GNG10; GNG12; GNG2; GNG3; GNG4; GNG5; GNG7; GNGT2; KCNJ10; KCNJ12; KCNJ15; KCNJ16; KCNJ2; KCNJ3; KCNJ4; KCNJ5; KCNJ6"
"R-HSA-3906995","Diseases associated with O-glycosylation of proteins",-0.0885679017377974,0.196187105153635,0.651668070498524,50,"ADAMTS10; ADAMTS12; ADAMTS13; ADAMTS14; ADAMTS15; ADAMTS16; ADAMTS17; ADAMTS18; ADAMTS19; ADAMTS2; ADAMTS3; ADAMTS4; ADAMTS5; ADAMTS6; ADAMTS7; ADAMTS8; ADAMTS9; ADAMTSL1; ADAMTSL2; ADAMTSL3; ADAMTSL4; ADAMTSL5; DAG1; MUC1; MUC12; MUC13; MUC15; MUC16; MUC20; MUC21; MUC3A; MUC4; MUC5B; MUC6; MUC7; MUCL1; NOTCH1; NOTCH2; NOTCH3; NOTCH4; SBSPON; SEMA5A; SEMA5B; SPON2; THBS1; THBS2; THSD1; THSD4; THSD7A; THSD7B"
"R-HSA-2454202","Fc epsilon receptor (FCERI) signaling",-0.150791123595161,0.334171551700836,0.651817548167178,17,"AHCYL1; BCL10; BTRC; CALM1; CARD11; CDC34; CHUK; CUL1; FBXW11; FCER1A; FCER1G; FOS; FYN; GAB2; GRAP2; GRB2; HRAS"
"R-HSA-68962","Activation of the pre-replicative complex",0.114987282307752,0.255603237103872,0.652806849051803,29,"CDC45; CDC6; CDC7; CDK2; CDT1; DBF4; MCM10; MCM2; MCM3; MCM4; MCM5; MCM6; MCM7; MCM8; ORC1; ORC3; ORC4; ORC5; ORC6; POLA2; POLE; POLE2; POLE3; POLE4; PRIM1; PRIM2; RPA1; RPA2; RPA3"
"R-HSA-168181","Toll Like Receptor 7/8 (TLR7/8) Cascade",0.0822690853021387,0.183253674806119,0.653478165827169,57,"AGER; APP; ATF1; ATF2; BTRC; CD14; CHUK; CUL1; DHX36; DUSP3; DUSP4; DUSP7; ECSIT; FBXW11; FOS; IKBKB; IRAK2; IRAK4; IRF7; LY96; MAP2K1; MAP2K3; MAP2K4; MAP2K6; MAP2K7; MAP3K1; MAP3K7; MAP3K8; MAPK1; MAPK10; MAPK11; MAPK14; MAPK3; MAPK8; MAPK9; MAPKAPK2; MAPKAPK3; MEF2A; MEF2C; MYD88; NFKB1; NFKB2; NFKBIA; NFKBIB; NKIRAS1; NOD1; NOD2; PELI1; PELI2; PELI3; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5D; RELA; RIPK2"
"R-HSA-975155","MyD88 dependent cascade initiated on endosome",0.0822690853021387,0.183253674806119,0.653478165827169,57,"AGER; APP; ATF1; ATF2; BTRC; CD14; CHUK; CUL1; DHX36; DUSP3; DUSP4; DUSP7; ECSIT; FBXW11; FOS; IKBKB; IRAK2; IRAK4; IRF7; LY96; MAP2K1; MAP2K3; MAP2K4; MAP2K6; MAP2K7; MAP3K1; MAP3K7; MAP3K8; MAPK1; MAPK10; MAPK11; MAPK14; MAPK3; MAPK8; MAPK9; MAPKAPK2; MAPKAPK3; MEF2A; MEF2C; MYD88; NFKB1; NFKB2; NFKBIA; NFKBIB; NKIRAS1; NOD1; NOD2; PELI1; PELI2; PELI3; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5D; RELA; RIPK2"
"R-HSA-9006925","Intracellular signaling by second messengers",0.0804455240270503,0.180175601985659,0.655247665416426,59,"ADCY1; ADCY2; ADCY3; ADCY4; ADCY5; ADCY6; ADCY7; ADCY9; AGO1; AGO2; AGO3; AGO4; AHCYL1; AKT1; AKT1S1; AKT2; AKT3; ATF2; ATN1; BAD; BMI1; BTC; CALM1; CAMK4; CASP9; CBX2; CBX4; CBX6; CBX8; CD19; CD28; CD80; CD86; CDKN1B; CHD3; CHD4; CHUK; CNOT6L; CSNK2A2; CSNK2B; EED; EGF; EGFR; EGR1; ERBB2; ERBB3; ERBB4; EREG; ESR1; ESR2; EZH2; FGF1; FGF10; FGF17; FGF18; FGF2; FGF20; FGF22; FGF5"
"R-HSA-4419969","Depolymerisation of the Nuclear Lamina",-0.163514682174538,0.367658390199058,0.656503157774974,14,"CCNB1; CDK1; CNEP1R1; CTDNEP1; LEMD2; LEMD3; LMNA; LMNB1; LPIN1; LPIN2; LPIN3; PRKCA; PRKCB; TMPO"
"R-HSA-159230","Transport of the SLBP Dependant Mature mRNA",-0.11048107290855,0.248545078930971,0.656673028474533,31,"ALYREF; EIF4E; NCBP1; NCBP2; NDC1; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188; NUP205; NUP210; NUP214; NUP35; NUP43; NUP50; NUP54; NUP58; NUP62; NUP85; NUP88; NUP93; NUP98; NUPL2; NXF1; POM121; RAE1; RANBP2; SEH1L; SLBP"
"R-HSA-1912420","Pre-NOTCH Processing in Golgi",0.143090404763273,0.323079490405273,0.65784142921589,18,"ATP2A1; ATP2A2; ATP2A3; B4GALT1; FURIN; LFNG; MFNG; NOTCH1; NOTCH2; NOTCH3; NOTCH4; RAB6A; RFNG; SEL1L; ST3GAL3; ST3GAL4; ST3GAL6; TMED2"
"R-HSA-912446","Meiotic recombination",0.102226669688494,0.233076571599892,0.660953619016167,35,"ATM; BLM; BRCA1; BRCA2; CDK2; CDK4; DMC1; H2AFJ; H2AFV; H2AFX; H2AFZ; H2BFS; H3F3A; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HIST2H2AA3; HIST2H2AC; MLH1; MLH3; MND1; MRE11; MSH4; MSH5; NBN; PSMC3IP; RAD50; RAD51; RAD51C; RBBP8; RPA1; RPA2; RPA3; TOP3A"
"R-HSA-5625886","Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3",0.14117814309394,0.323159531847654,0.662206890088011,18,"H2AFJ; H2AFV; H2AFX; H2AFZ; H2BFS; H3F3A; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HIST2H2AA3; HIST2H2AC; KDM1A; KDM4C; KLK2; KLK3; NCOA2; PKN1"
"R-HSA-5578749","Transcriptional regulation by small RNAs",0.0870446576151084,0.199495579194736,0.662601858488346,48,"AGO1; AGO2; H2AFJ; H2AFV; H2AFX; H2AFZ; H2BFS; H3F3A; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HIST2H2AA3; HIST2H2AC; IPO8; NDC1; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188; NUP205; NUP210; NUP214; NUP35; NUP43; NUP50; NUP54; NUP58; NUP62; NUP85; NUP88; NUP93; NUP98; NUPL2; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; POM121"
"R-HSA-180292","GAB1 signalosome",0.186806601852447,0.430385214168369,0.664255676655492,10,"CSK; EGF; EGFR; GAB1; GRB2; PAG1; PIK3CA; PIK3R1; PXN; SRC"
"R-HSA-446219","Synthesis of substrates in N-glycan biosythesis",0.0808178277085374,0.186547991844298,0.664849083484056,55,"ALG5; AMDHD2; CMAS; CTSA; DHDDS; DOLK; DOLPP1; DPM1; DPM2; FPGT; FUOM; GFPT1; GFPT2; GLB1; GMDS; GMPPB; GNE; GNPNAT1; MPI; MVD; NAGK; NANP; NANS; NEU1; NEU3; NEU4; NPL; NUDT14; NUS1; PGM3; PMM1; PMM2; SLC17A5; SLC35A1; SLC35C1; SRD5A3; ST3GAL1; ST3GAL3; ST3GAL4; ST3GAL5; ST3GAL6; ST6GAL1; ST6GAL2; ST6GALNAC1; ST6GALNAC2; ST6GALNAC3; ST6GALNAC4; ST6GALNAC6; ST8SIA1; ST8SIA2; ST8SIA4; ST8SIA5; ST8SIA6; TSTA3; UAP1"
"R-HSA-446728","Cell junction organization",-0.0763613979297779,0.176436834716538,0.665161984611516,62,"ACTN1; AFDN; ANG; CADM1; CADM2; CADM3; CD151; CDH1; CDH10; CDH11; CDH12; CDH13; CDH15; CDH17; CDH18; CDH2; CDH24; CDH3; CDH4; CDH5; CDH6; CDH7; CDH8; CLDN1; CLDN10; CLDN11; CLDN12; CLDN14; CLDN15; CLDN16; CLDN18; CLDN19; CLDN20; CLDN23; CLDN3; CLDN4; CLDN5; CLDN6; CLDN7; CLDN8; CLDN9; COL17A1; CRB3; CTNNA1; CTNNB1; CTNND1; DST; F11R; FBLIM1; FERMT2; FLNC; ILK; ITGA6; ITGB1; ITGB4; JUP; LAMA3; LAMB3; LAMC2; LIMS1; LIMS2; MPP5"
"R-HSA-5334118","DNA methylation",0.152733002687471,0.353373970066014,0.665586243750707,15,"DNMT1; DNMT3A; DNMT3B; H2AFJ; H2AFV; H2AFX; H2AFZ; H2BFS; H3F3A; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HIST2H2AA3; HIST2H2AC"
"R-HSA-3238698","WNT ligand biogenesis and trafficking",-0.132671758467562,0.308649545292016,0.667307701634269,20,"SNX3; TMED5; VPS29; VPS35; WLS; WNT10B; WNT11; WNT16; WNT2; WNT2B; WNT3; WNT4; WNT5A; WNT5B; WNT6; WNT7A; WNT7B; WNT8B; WNT9A; WNT9B"
"R-HSA-77289","Mitochondrial Fatty Acid Beta-Oxidation",0.100125087476006,0.233124160669824,0.66756482298775,35,"ACAA2; ACAD10; ACAD11; ACADL; ACADM; ACADS; ACADVL; ACBD7; ACOT1; ACOT11; ACOT12; ACOT13; ACOT2; ACOT7; ACSF2; ACSM3; ACSM6; DBI; DECR1; ECHS1; ECI1; HADH; HADHA; HADHB; MCAT; MCEE; MECR; MMAA; MUT; NDUFAB1; PCCA; PCCB; PCTP; THEM4; THEM5"
"R-HSA-1810476","RIP-mediated NFkB activation via ZBP1",-0.135762306579828,0.316550417162538,0.668010179415963,19,"AGER; APP; CHUK; IKBKB; MYD88; NFKB1; NFKB2; NFKBIA; NFKBIB; NKIRAS1; RELA; RIPK1; RIPK3; S100A12; S100B; SAA1; TICAM1; TLR3; ZBP1"
"R-HSA-416482","G alpha (12/13) signalling events",0.0766142465558975,0.178735432929868,0.668180790098763,60,"ABR; ADRA1A; ADRA1B; ADRA1D; AKAP13; ARHGEF10; ARHGEF10L; ARHGEF11; ARHGEF12; ARHGEF15; ARHGEF16; ARHGEF17; ARHGEF18; ARHGEF19; ARHGEF2; ARHGEF26; ARHGEF3; ARHGEF33; ARHGEF35; ARHGEF37; ARHGEF38; ARHGEF39; ARHGEF4; ARHGEF40; ARHGEF5; ARHGEF7; CDC42; ECT2; FGD2; FGD3; FGD4; GNA12; GNA13; GNB1; GNB2; GNB3; GNB4; GNB5; GNG10; GNG11; GNG12; GNG2; GNG3; GNG4; GNG5; GNG7; GNGT2; ITSN1; KALRN; MCF2L; NET1; NGEF; OBSCN; PIK3CA; PIK3R1; PIK3R2; PIK3R3; PLEKHG2; PLEKHG5; PLXNB1"
"R-HSA-2173788","Downregulation of TGF-beta receptor signaling",-0.129138494004062,0.301328245697057,0.668240414280573,21,"BAMBI; MTMR4; NEDD4L; PMEPA1; PPP1CB; PPP1R15A; SMAD2; SMAD3; SMURF1; SMURF2; STRAP; STUB1; TGFB1; TGFBR1; TGFBR2; UBA52; UBC; UCHL5; USP15; XPO1; ZFYVE9"
"R-HSA-5654710","PI-3K cascade:FGFR3",-0.163269050032503,0.38151646325828,0.668689279841046,13,"FGF1; FGF17; FGF18; FGF2; FGF20; FGF5; FGF9; FGFR3; FRS2; GAB1; GRB2; PIK3CA; PIK3R1"
"R-HSA-8943724","Regulation of PTEN gene transcription",0.0808809106325061,0.190003128505568,0.670339584194102,53,"ATF2; ATN1; BMI1; CBX2; CBX4; CBX6; CBX8; CHD3; CHD4; EED; EGR1; EZH2; GATAD2A; GATAD2B; HDAC1; HDAC2; HDAC3; HDAC5; HDAC7; KDM1A; LAMTOR2; LAMTOR3; LAMTOR4; LAMTOR5; MAF1; MAPK1; MAPK3; MBD3; MECOM; MLST8; MTA2; MTA3; MTOR; PHC1; PHC2; PHC3; PPARG; PTEN; RBBP4; REST; RHEB; RING1; RNF2; RPTOR; RRAGA; RRAGC; RRAGD; SALL4; SCMH1; SLC38A9; SNAI1; SNAI2; SUZ12"
"R-HSA-446652","Interleukin-1 family signaling",-0.0782805088244381,0.183929720661058,0.670399262182834,57,"AGER; ALOX5; APP; BTRC; CASP1; CHUK; CUL1; FBXW11; IKBKB; IL13; IL18; IL18BP; IL18R1; IL18RAP; IL1A; IL1B; IL1F10; IL1R1; IL1R2; IL1RAP; IL1RL1; IL1RL2; IL1RN; IL33; IL36B; IL36G; IL36RN; IL4; IRAK2; IRAK3; IRAK4; MAP2K1; MAP2K4; MAP2K6; MAP3K3; MAP3K7; MAP3K8; MAPK8; MYD88; NFKB1; NFKB2; NFKBIA; NFKBIB; NKIRAS1; NOD1; NOD2; PELI1; PELI2; PELI3; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10"
"R-HSA-982772","Growth hormone receptor signaling",0.127460465347895,0.299748258192046,0.670672631433507,21,"ADAM17; CISH; GHR; IRS1; IRS2; JAK2; LYN; MAPK1; MAPK3; PRL; PRLR; PTPN1; PTPN6; SH2B1; SOCS1; SOCS2; SOCS3; STAT1; STAT3; STAT5A; STAT5B"
"R-HSA-6811434","COPI-dependent Golgi-to-ER retrograde traffic",0.0777046178841729,0.183320485158657,0.671658380811419,57,"ARCN1; ARF3; ARF4; ARF5; ARFGAP1; ARFGAP2; ARFGAP3; BNIP1; CENPE; COPA; COPB1; COPB2; COPE; COPG1; COPG2; COPZ1; COPZ2; GBF1; KDELR1; KDELR2; KDELR3; KIF11; KIF12; KIF13B; KIF15; KIF16B; KIF18B; KIF19; KIF1A; KIF1B; KIF1C; KIF20A; KIF20B; KIF21A; KIF21B; KIF25; KIF26A; KIF26B; KIF27; KIF2A; KIF2C; KIF3A; KIF3C; KIF5A; KIF5B; KIF5C; KIF6; KIF9; KIFAP3; KIFC2; KLC1; KLC2; KLC4; NAPA; NAPB; NAPG; NBAS"
"R-HSA-211981","Xenobiotics",0.126905103066979,0.299767888927582,0.672043892457123,21,"AHR; ARNT; ARNT2; CYP1A1; CYP1A2; CYP2A13; CYP2A6; CYP2A7; CYP2C18; CYP2C19; CYP2C8; CYP2C9; CYP2D6; CYP2E1; CYP2F1; CYP2J2; CYP2S1; CYP2W1; CYP3A43; CYP3A5; CYP3A7"
"R-HSA-5602498","MyD88 deficiency (TLR2/4)",-0.183593434907743,0.433824189026031,0.672150964355329,10,"CD14; CD36; IRAK4; LY96; MYD88; TIRAP; TLR1; TLR2; TLR4; TLR6"
"R-HSA-5603041","IRAK4 deficiency (TLR2/4)",-0.183593434907743,0.433824189026031,0.672150964355329,10,"CD14; CD36; IRAK4; LY96; MYD88; TIRAP; TLR1; TLR2; TLR4; TLR6"
"R-HSA-6807004","Negative regulation of MET activity",0.136191613911044,0.32336416927971,0.673630211428108,18,"CBL; EPS15; GRB2; HGF; HGS; LRIG1; MET; PTPN1; PTPN2; PTPRJ; SH3GL1; SH3GL2; SH3GL3; STAM; STAM2; UBA52; UBC; USP8"
"R-HSA-3371556","Cellular response to heat stress",0.0783896057106298,0.18658410938553,0.674390394681351,55,"AKT1S1; ATM; ATR; BAG1; BAG2; BAG3; BAG5; CAMK2A; CAMK2B; CAMK2D; CAMK2G; CCAR2; CRYAB; CRYBA4; DNAJB1; DNAJB6; DNAJC2; DNAJC7; EP300; FKBP4; GSK3B; HIKESHI; HSBP1; HSF1; HSP90AA1; HSP90AB1; HSPA12A; HSPA12B; HSPA13; HSPA14; HSPA1B; HSPA1L; HSPA2; HSPA4; HSPA4L; HSPA6; HSPA8; HSPB8; HSPH1; MAPK1; MAPK3; MAPKAPK2; MLST8; MRPL18; MTOR; NDC1; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188; NUP205; NUP210; NUP214"
"R-HSA-5654741","Signaling by FGFR3",0.102082383987468,0.243706168909722,0.675307601232551,32,"BRAF; CBL; FGF1; FGF17; FGF18; FGF2; FGF20; FGF5; FGF9; FGFR3; FRS2; FRS3; GAB1; GALNT3; GRB2; HRAS; KRAS; MAPK1; MAPK3; MKNK1; NRAS; PIK3CA; PIK3R1; PLCG1; PPP2CA; PPP2CB; PPP2R1A; SHC1; SOS1; SRC; UBA52; UBC"
"R-HSA-5654732","Negative regulation of FGFR3 signaling",-0.126053082878609,0.301402065302036,0.675784549423539,21,"BRAF; CBL; FGF1; FGF17; FGF18; FGF2; FGF20; FGF5; FGF9; FGFR3; FRS2; GRB2; MAPK1; MAPK3; MKNK1; PPP2CA; PPP2CB; PPP2R1A; SRC; UBA52; UBC"
"R-HSA-451326","Activation of kainate receptors upon glutamate binding",0.11264402114358,0.269951996875076,0.676477809779185,26,"CALM1; DLG1; DLG4; GNB1; GNB2; GNB3; GNB4; GNB5; GNG10; GNG11; GNG12; GNG2; GNG3; GNG4; GNG5; GNG7; GNGT2; GRIK1; GRIK2; GRIK3; GRIK4; GRIK5; NCALD; PLCB1; PLCB2; PLCB3"
"R-HSA-177243","Interactions of Rev with host cellular proteins",-0.101909245506742,0.244776404975554,0.677164104822818,32,"KPNB1; NDC1; NPM1; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188; NUP205; NUP210; NUP214; NUP35; NUP43; NUP50; NUP54; NUP58; NUP62; NUP85; NUP88; NUP93; NUP98; NUPL2; POM121; RAE1; RAN; RANBP1; RANBP2; RANGAP1; RCC1; SEH1L; XPO1"
"R-HSA-71336","Pentose phosphate pathway (hexose monophosphate shunt)",0.177794506921247,0.431011045661007,0.679968814190907,10,"DERA; PGD; PGLS; PGM2; RBKS; RPE; RPIA; SHPK; TALDO1; TKT"
"R-HSA-3296469","Defects in cobalamin (B12) metabolism",-0.17071464750488,0.414330337836728,0.680320763096436,11,"AMN; CD320; CUBN; GIF; MMAA; MMACHC; MMADHC; MTR; MTRR; MUT; TCN2"
"R-HSA-71403","Citric acid cycle (TCA cycle)",0.136478837843664,0.332701034113639,0.681648496032436,17,"ACO2; CS; DLD; DLST; IDH2; IDH3A; IDH3B; MDH2; NNT; OGDH; SDHA; SDHB; SDHC; SDHD; SUCLA2; SUCLG1; SUCLG2"
"R-HSA-9014325","TICAM1,TRAF6-dependent induction of TAK1 complex",0.155060760486501,0.379400363777279,0.682760159150302,13,"CD14; IRAK2; LY96; MAP3K7; TAB1; TAB2; TICAM1; TICAM2; TLR3; TLR4; TRAF6; UBA52; UBC"
"R-HSA-975163","IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation",0.155060760486501,0.379400363777279,0.682760159150302,13,"CD14; IRAK2; LY96; MAP3K7; TAB1; TAB2; TICAM1; TICAM2; TLR3; TLR4; TRAF6; UBA52; UBC"
"R-HSA-76009","Platelet Aggregation (Plug Formation)",0.0980215231904545,0.240097264041909,0.683084593625142,33,"ADRA2A; ADRA2C; AKT1; APBB1IP; BCAR1; CRK; CSK; F2; FGA; FGB; FGG; FN1; GP1BA; GP5; GRB2; ITGA2B; ITGB3; MPL; PDPK1; PTK2; PTPN1; RAP1A; RAP1B; RAPGEF3; RAPGEF4; RASGRP1; SHC1; SOS1; SRC; SYK; THPO; TLN1; VWF"
"R-HSA-167044","Signalling to RAS",0.125120352699292,0.307204842390103,0.683797654167683,20,"GRB2; HRAS; KRAS; MAPK11; MAPK12; MAPK13; MAPK14; MAPKAPK2; MAPKAPK3; NGF; NRAS; NTRK1; RALA; RALB; RALGDS; SHC1; SHC2; SHC3; SOS1; SRC"
"R-HSA-113510","E2F mediated regulation of DNA replication",-0.132500191620327,0.325326446906247,0.683799559486736,18,"CCNB1; CDK1; E2F1; MCM8; ORC1; ORC3; ORC4; ORC5; ORC6; POLA2; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PRIM1; PRIM2; RB1; TFDP1"
"R-HSA-5601884","PIWI-interacting RNA (piRNA) biogenesis",-0.11250864471396,0.276604567915911,0.68419231241804,25,"DDX4; HENMT1; HSP90AA1; MAEL; MOV10L1; MYBL1; PIWIL1; PIWIL2; PIWIL4; PLD6; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; TDRD12; TDRD6; TDRD9; TDRKH"
"R-HSA-170834","Signaling by TGF-beta Receptor Complex",0.0732966244884468,0.180275431591926,0.684315512987505,59,"ARHGEF18; BAMBI; CBL; CCNC; CCNK; CCNT1; CCNT2; CDK8; CDK9; CDKN2B; CGN; E2F4; E2F5; F11R; FKBP1A; FURIN; HDAC1; JUNB; MEN1; MTMR4; MYC; NCOR1; NEDD4L; NEDD8; PARD3; PARD6A; PARP1; PMEPA1; PPM1A; PPP1CB; PPP1R15A; PRKCZ; RBL1; RNF111; SERPINE1; SKI; SKIL; SMAD2; SMAD3; SMAD4; SMURF1; SMURF2; SNW1; SP1; STRAP; STUB1; TFDP1; TGFB1; TGFBR1; TGFBR2; TGIF1; TGIF2; TRIM33; UBA52; UBC; UBE2D1; UBE2D3; UBE2M; UCHL5"
"R-HSA-156588","Glucuronidation",-0.143512401851083,0.355946939290423,0.686812267693065,15,"ABHD10; SLC35D1; UGDH; UGP2; UGT1A1; UGT1A10; UGT1A4; UGT1A6; UGT2B11; UGT2B15; UGT2B17; UGT2B28; UGT2B4; UGT2B7; UGT3A2"
"R-HSA-8949664","Processing of SMDT1",0.145425529479519,0.366109242521895,0.691206008054942,14,"MCU; MCUB; MICU1; MICU2; MICU3; PARL; PHB; PHB2; PMPCA; PMPCB; SMDT1; SPG7; STOML2; YME1L1"
"R-HSA-1428517","The citric acid (TCA) cycle and respiratory electron transport",0.069963353299106,0.177366064469302,0.69324338661193,61,"ACAD9; ACO2; ADHFE1; ATP5A1; ATP5B; ATP5C1; ATP5D; ATP5E; ATP5F1; ATP5G1; ATP5G2; ATP5G3; ATP5H; ATP5I; ATP5J2; ATP5L; ATP5O; ATP5S; BSG; COQ10A; COQ10B; COX11; COX14; COX16; COX18; COX19; COX20; COX4I1; COX5A; COX5B; COX6A1; COX6B1; COX6C; COX7A2L; COX8A; CS; CYC1; CYCS; D2HGDH; DLAT; DLD; DLST; ECSIT; ETFA; ETFB; ETFDH; GLO1; HAGH; IDH2; IDH3A; IDH3B; L2HGDH; LDHA; LDHAL6A; LDHAL6B; LDHB; LDHC; LRPPRC; MDH2; MPC1; MPC2"
"R-HSA-180024","DARPP-32 events",-0.121662598113241,0.308918599095231,0.69370371868604,20,"CALM1; PDE4A; PDE4B; PDE4C; PDE4D; PPP1R1B; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5D; PPP3CA; PPP3CB; PPP3CC; PPP3R1; PRKACB; PRKAR1A; PRKAR1B; PRKAR2A; PRKAR2B"
"R-HSA-354192","Integrin alphaIIb beta3 signaling",0.106238318763411,0.27013216117565,0.694110658630214,26,"AKT1; APBB1IP; BCAR1; CRK; CSK; FGA; FGB; FGG; FN1; GRB2; ITGA2B; ITGB3; PDPK1; PTK2; PTPN1; RAP1A; RAP1B; RAPGEF3; RAPGEF4; RASGRP1; SHC1; SOS1; SRC; SYK; TLN1; VWF"
"R-HSA-9006921","Integrin signaling",0.106238318763411,0.27013216117565,0.694110658630214,26,"AKT1; APBB1IP; BCAR1; CRK; CSK; FGA; FGB; FGG; FN1; GRB2; ITGA2B; ITGB3; PDPK1; PTK2; PTPN1; RAP1A; RAP1B; RAPGEF3; RAPGEF4; RASGRP1; SHC1; SOS1; SRC; SYK; TLN1; VWF"
"R-HSA-211945","Phase I - Functionalization of compounds",-0.0693878054382304,0.17647677169449,0.694183743420639,62,"AADAC; ACSS1; ACSS2; ADH1A; ADH1B; ADH4; ADH5; ADH6; AHR; AHRR; AIP; ALDH1A1; ALDH1B1; ALDH2; ALDH3A1; AOC1; AOC2; AOC3; ARNT; ARNT2; BPHL; CBR3; CES1; CES2; CES3; CMBL; CYB5B; CYB5R3; CYP11A1; CYP11B1; CYP17A1; CYP19A1; CYP1A1; CYP1A2; CYP1B1; CYP21A2; CYP24A1; CYP26B1; CYP26C1; CYP27A1; CYP27B1; CYP2A13; CYP2A6; CYP2A7; CYP2C18; CYP2C19; CYP2C8; CYP2C9; CYP2D6; CYP2E1; CYP2F1; CYP2J2; CYP2R1; CYP2S1; CYP2U1; CYP2W1; CYP39A1; CYP3A43; CYP3A5; CYP3A7; CYP46A1; CYP4A11"
"R-HSA-70171","Glycolysis",0.072614460202067,0.185007403873085,0.694692587994833,56,"ADPGK; ALDOB; ALDOC; BPGM; ENO1; ENO2; ENO3; GAPDH; GCK; GCKR; GNPDA1; GNPDA2; GPI; HK1; HK2; NDC1; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188; NUP205; NUP210; NUP214; NUP35; NUP43; NUP50; NUP54; NUP58; NUP62; NUP85; NUP88; NUP93; NUP98; NUPL2; PFKFB2; PFKFB3; PFKFB4; PFKL; PFKM; PFKP; PGAM1; PGM2L1; PGP; PKLR; PKM; POM121; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5D; PRKACB; RAE1; RANBP2"
"R-HSA-195258","RHO GTPase Effectors",-0.0733762106500496,0.188957392353306,0.697778157432983,54,"ABI1; ABL1; ACTG1; ACTR2; ACTR3; AHCTF1; ARPC1A; ARPC1B; ARPC2; ARPC3; ARPC4; ARPC5; AURKB; B9D2; BAIAP2; BIRC5; BRK1; BUB1B; BUB3; CALM1; CDC42; CDH1; CDKN1B; CENPA; CENPC; CENPE; CENPF; CENPH; CENPK; CENPL; CENPM; CENPN; CENPO; CENPP; CENPQ; CENPT; CENPU; CFL1; CFTR; CIT; CKAP5; CLASP1; CLIP1; CTNNA1; CTNNB1; CTTN; CYBA; CYFIP2; DAAM1; DIAPH1; DIAPH3; DLG4; DSN1; DVL1"
"R-HSA-5654733","Negative regulation of FGFR4 signaling",0.115614342511425,0.300152256427318,0.700099873035363,21,"BRAF; CBL; FGF1; FGF17; FGF18; FGF2; FGF20; FGF9; FGFR4; FRS2; GRB2; KLB; MAPK1; MAPK3; MKNK1; PPP2CA; PPP2CB; PPP2R1A; SRC; UBA52; UBC"
"R-HSA-422475","Axon guidance",0.0668696546247516,0.174592729217738,0.701717048960181,63,"ABL1; ABL2; ABLIM1; ABLIM2; ABLIM3; ACTG1; ACTR2; ACTR3; ADAM10; AGAP2; AGRN; ALCAM; ANK1; ANK2; ANK3; AP2A1; AP2A2; AP2B1; AP2M1; AP2S1; APH1A; APH1B; ARHGAP35; ARHGAP39; ARHGEF11; ARHGEF12; ARHGEF28; ARHGEF7; ARPC1A; ARPC1B; ARPC2; ARPC3; ARPC4; ARPC5; ARTN; CACNA1C; CACNA1D; CACNA1G; CACNA1H; CACNA1I; CACNA1S; CACNB1; CACNB2; CACNB3; CACNB4; CAP1; CAP2; CASC3; CD72; CDC42; CDK5R1; CFL1; CHL1; CLASP1; CLTA; CLTB; CLTC; CLTCL1; CNTN1; CNTN2; CNTN6; CNTNAP1; COL4A1"
"R-HSA-5654726","Negative regulation of FGFR1 signaling",0.109887781508677,0.287031926916773,0.701837164687839,23,"BRAF; CBL; FGF1; FGF10; FGF17; FGF2; FGF20; FGF22; FGF5; FGF9; FGFR1; FRS2; GRB2; KL; MAPK1; MAPK3; MKNK1; PPP2CA; PPP2CB; PPP2R1A; SRC; UBA52; UBC"
"R-HSA-1538133","G0 and Early G1",0.104752135095679,0.27550161322147,0.703779657962403,25,"CCNA1; CCNA2; CCNE1; CCNE2; CDC25A; CDC6; CDK1; CDK2; DYRK1A; E2F1; E2F4; E2F5; HDAC1; LIN37; LIN52; LIN54; LIN9; MAX; MYBL2; MYC; PCNA; RBBP4; RBL1; RBL2; TFDP1"
"R-HSA-5621480","Dectin-2 family",-0.120206821591211,0.316944259140267,0.704488845165598,19,"CLEC10A; FCER1G; FYN; LYN; MUC1; MUC12; MUC13; MUC15; MUC16; MUC20; MUC21; MUC3A; MUC4; MUC5B; MUC6; MUC7; MUCL1; PLCG2; SYK"
"R-HSA-8979227","Triglyceride metabolism",0.105532498872776,0.281137921076629,0.707380664579697,24,"AGMO; CAV1; DGAT1; DGAT2; FABP1; FABP2; FABP3; FABP4; FABP6; FABP7; GPAM; GPAT2; GPD2; LIPE; LPIN1; LPIN2; LPIN3; MGLL; MOGAT2; PLIN1; PLIN3; PNPLA5; PPP1CB; PRKACB"
"R-HSA-983712","Ion channel transport",-0.065719615205527,0.175101801498291,0.707420764948323,63,"ANO1; ANO10; ANO2; ANO3; ANO4; ANO5; ANO6; ANO7; ANO8; ANO9; ASIC1; ASIC2; ASIC3; ASIC4; ASPH; ATP10A; ATP10B; ATP10D; ATP11A; ATP11B; ATP12A; ATP13A1; ATP13A2; ATP13A4; ATP13A5; ATP1A1; ATP1A2; ATP1A3; ATP1A4; ATP1B1; ATP1B2; ATP1B3; ATP2A1; ATP2A2; ATP2A3; ATP2B1; ATP2B2; ATP2B4; ATP2C1; ATP2C2; ATP4A; ATP4B; ATP6V0A1; ATP6V0A2; ATP6V0A4; ATP6V0B; ATP6V0C; ATP6V0D1; ATP6V0D2; ATP6V0E1; ATP6V0E2; ATP6V1A; ATP6V1B1; ATP6V1B2; ATP6V1C1; ATP6V1C2; ATP6V1D; ATP6V1E1; ATP6V1E2; ATP6V1F; ATP6V1G1; ATP6V1G2; ATP6V1H"
"R-HSA-196757","Metabolism of folate and pterines",-0.129319439635537,0.345098931239527,0.707860164003509,16,"ALDH1L1; ALDH1L2; DHFR; DHFR2; FOLR2; FPGS; MTHFD1; MTHFD1L; MTHFD2; MTHFD2L; MTHFR; MTHFS; SHMT1; SLC19A1; SLC25A32; SLC46A1"
"R-HSA-5627123","RHO GTPases activate PAKs",-0.117694919382898,0.317001926704854,0.710432648249649,19,"CALM1; CDC42; CTTN; LIMK1; MYH10; MYH11; MYH14; MYH9; MYL12B; MYL6; MYL9; MYLK; NF2; PAK1; PAK2; PPP1CB; PPP1R12A; PPP1R12B; RAC1"
"R-HSA-445095","Interaction between L1 and Ankyrins",0.0984050520710519,0.26530827522145,0.710705802792013,27,"ANK1; ANK2; ANK3; KCNQ2; KCNQ3; NFASC; NRCAM; SCN10A; SCN11A; SCN1A; SCN1B; SCN2A; SCN2B; SCN3A; SCN3B; SCN4A; SCN4B; SCN5A; SCN7A; SCN8A; SCN9A; SPTA1; SPTB; SPTBN1; SPTBN2; SPTBN4; SPTBN5"
"R-HSA-112316","Neuronal System",-0.0654950172318309,0.17792379072697,0.71279334931485,61,"ABAT; ABCC8; ABCC9; ACHE; ACTN2; ADCY1; ADCY2; ADCY3; ADCY4; ADCY5; ADCY6; ADCY7; ADCY9; AKAP9; ALDH2; ALDH5A1; AP2A1; AP2A2; AP2B1; AP2M1; AP2S1; APBA1; APBA2; APBA3; ARL6IP5; BCHE; BEGAIN; BRAF; CACFD1; CACNA1A; CACNA1B; CACNA1E; CACNA2D1; CACNA2D2; CACNA2D3; CACNB1; CACNB2; CACNB3; CACNB4; CACNG3; CACNG4; CACNG8; CALM1; CAMK2A; CAMK2B; CAMK2D; CAMK2G; CAMK4; CAMKK1; CHRNA1; CHRNA2; CHRNA3; CHRNA4; CHRNA5; CHRNA6; CHRNA7; CHRNB2; CHRNB3; CHRNB4; CHRND; CHRNE"
"R-HSA-177504","Retrograde neurotrophin signalling",0.134907227649228,0.366604836042578,0.712880051947104,14,"AP2A1; AP2A2; AP2B1; AP2M1; AP2S1; CLTA; CLTC; DNAL4; DNM1; DNM2; DNM3; NGF; NTRK1; SH3GL2"
"R-HSA-917729","Endosomal Sorting Complex Required For Transport (ESCRT)",-0.0940297953071358,0.257178737131276,0.714648343126469,29,"CHMP2A; CHMP2B; CHMP3; CHMP4A; CHMP4B; CHMP4C; CHMP5; CHMP6; CHMP7; HGS; MVB12A; MVB12B; SNF8; STAM; STAM2; TSG101; UBA52; UBAP1; UBC; VPS25; VPS28; VPS36; VPS37A; VPS37B; VPS37C; VPS37D; VPS4A; VPS4B; VTA1"
"R-HSA-8984722","Interleukin-35 Signalling",-0.1517292263069,0.415192082366529,0.714780413481,11,"CANX; IL12A; IL12RB2; IL27RA; IL6ST; JAK1; JAK2; STAT1; STAT3; STAT4; TYK2"
"R-HSA-168255","Influenza Life Cycle",0.0700674140068263,0.19196498874092,0.715110655301892,52,"CALR; CANX; CLTA; CLTC; DNAJC3; FAU; GRSF1; GTF2F1; GTF2F2; HSP90AA1; IPO5; KPNA1; KPNB1; NDC1; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188; NUP205; NUP210; NUP214; NUP35; NUP43; NUP50; NUP54; NUP58; NUP62; NUP85; NUP88; NUP93; NUP98; NUPL2; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; POM121; RAE1; RAN; RANBP2; RPL10A; RPL12; RPL13"
"R-HSA-5635838","Activation of SMO",0.125054550246719,0.343388944417922,0.715725417579792,16,"ARRB1; ARRB2; BOC; CDON; CSNK1A1; DHH; EFCAB7; EVC; EVC2; GAS1; GAS8; IHH; IQCE; KIF3A; PTCH1; SHH"
"R-HSA-3560782","Diseases associated with glycosaminoglycan metabolism",-0.107195984562038,0.294889556322935,0.716222217013205,22,"ACAN; AGRN; BCAN; CSPG4; CSPG5; DCN; FMOD; GPC1; GPC2; GPC5; GPC6; HSPG2; KERA; LUM; OGN; OMD; PRELP; SDC1; SDC2; SDC3; SDC4; VCAN"
"R-HSA-512988","Interleukin-3, 5 and GM-CSF signaling",0.0844874923730225,0.233454742089338,0.717426051826699,35,"BLNK; CBL; CRK; CRKL; CSF2RB; FYN; GAB2; GRB2; HCK; IL2RA; IL2RB; IL5; INPP5D; INPPL1; JAK1; JAK2; JAK3; LYN; PIK3CA; PIK3CB; PIK3CD; PIK3R1; PIK3R2; PIK3R3; PTPN6; RAPGEF1; SHC1; SOS1; STAT5A; STAT5B; SYK; TEC; VAV1; YES1; YWHAZ"
"R-HSA-1368082","RORA activates gene expression",0.103289392916888,0.287225795189719,0.719138479566419,23,"ARNTL; CARM1; CHD9; CLOCK; CPT1A; EP300; HDAC3; NCOA1; NCOA2; NCOA6; NCOR1; NPAS2; NR1D1; NRIP1; PPARA; PPARGC1A; RORA; RXRA; SIRT1; SMARCD3; SREBF1; TBL1XR1; TGS1"
"R-HSA-5607763","CLEC7A (Dectin-1) induces NFAT activation",-0.156305543077877,0.435214647945391,0.719485968736079,10,"AHCYL1; CALM1; ITPR1; ITPR2; ITPR3; NFATC1; NFATC3; PPP3CA; PPP3CB; PPP3R1"
"R-HSA-936837","Ion transport by P-type ATPases",-0.0694909713060197,0.194411390066625,0.720760264581843,51,"ATP10A; ATP10B; ATP10D; ATP11A; ATP11B; ATP12A; ATP13A1; ATP13A2; ATP13A4; ATP13A5; ATP1A1; ATP1A2; ATP1A3; ATP1A4; ATP1B1; ATP1B2; ATP1B3; ATP2A1; ATP2A2; ATP2A3; ATP2B1; ATP2B2; ATP2B4; ATP2C1; ATP2C2; ATP4A; ATP4B; ATP7B; ATP8A1; ATP8A2; ATP8B1; ATP8B2; ATP8B3; ATP8B4; ATP9A; ATP9B; CALM1; CAMK2A; CAMK2B; CAMK2D; CAMK2G; CUTC; FXYD1; FXYD2; FXYD3; FXYD4; FXYD6; FXYD7; PLN; SLN; SRI"
"R-HSA-376172","DSCAM interactions",-0.147443859331735,0.415368884528295,0.722611405297313,11,"DCC; DSCAM; DSCAML1; MAPK11; MAPK12; MAPK13; MAPK14; MAPK8; NTN1; PAK1; RAC1"
"R-HSA-209952","Peptide hormone biosynthesis",-0.154402315184205,0.435301203701135,0.722812667210693,10,"CGA; CGB3; INHA; INHBA; INHBB; INHBE; LHB; PCSK1; POMC; TSHB"
"R-HSA-1482801","Acyl chain remodelling of PS",0.109037329633216,0.307751083102958,0.723111338488609,20,"LPCAT3; LPCAT4; MBOAT1; OSBPL10; OSBPL5; OSBPL8; PLA1A; PLA2G10; PLA2G12A; PLA2G16; PLA2G1B; PLA2G2A; PLA2G2D; PLA2G4A; PLA2G4B; PLA2G4D; PLA2G4E; PLA2G4F; PLA2G5; PLA2R1"
"R-HSA-211979","Eicosanoids",-0.14683743367829,0.415393380000392,0.723721074219612,11,"CYP4A11; CYP4A22; CYP4B1; CYP4F11; CYP4F12; CYP4F2; CYP4F22; CYP4F3; CYP8B1; PTGIS; TBXAS1"
"R-HSA-182971","EGFR downregulation",0.106086503644398,0.300454699116208,0.724023579578591,21,"ARHGEF7; CBL; CDC42; EGF; EGFR; EPN1; EPS15; EPS15L1; GRB2; HGS; PTPN12; PTPN3; PTPRK; SH3GL1; SH3GL2; SH3GL3; SPRY1; STAM; STAM2; UBA52; UBC"
"R-HSA-389960","Formation of tubulin folding intermediates by CCT/TriC",0.100706718964439,0.287299169357606,0.725941655883203,23,"CCT2; CCT3; CCT4; CCT5; CCT6A; CCT6B; CCT7; CCT8; TCP1; TUBA1A; TUBA1B; TUBA1C; TUBA3C; TUBA3E; TUBA4A; TUBA8; TUBAL3; TUBB1; TUBB2A; TUBB2B; TUBB3; TUBB4A; TUBB6"
"R-HSA-168142","Toll Like Receptor 10 (TLR10) Cascade",0.0647811988638208,0.185111496300608,0.726370421425801,56,"AGER; APP; ATF1; ATF2; BTRC; CHUK; CUL1; DUSP3; DUSP4; DUSP7; ECSIT; FBXW11; FOS; IKBKB; IRAK2; IRAK4; MAP2K1; MAP2K3; MAP2K4; MAP2K6; MAP2K7; MAP3K1; MAP3K7; MAP3K8; MAPK1; MAPK10; MAPK11; MAPK14; MAPK3; MAPK8; MAPK9; MAPKAPK2; MAPKAPK3; MEF2A; MEF2C; MYD88; NFKB1; NFKB2; NFKBIA; NFKBIB; NKIRAS1; NOD1; NOD2; PELI1; PELI2; PELI3; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5D; RELA; RIPK2; RPS6KA1; RPS6KA2; RPS6KA5"
"R-HSA-168176","Toll Like Receptor 5 (TLR5) Cascade",0.0647811988638208,0.185111496300608,0.726370421425801,56,"AGER; APP; ATF1; ATF2; BTRC; CHUK; CUL1; DUSP3; DUSP4; DUSP7; ECSIT; FBXW11; FOS; IKBKB; IRAK2; IRAK4; MAP2K1; MAP2K3; MAP2K4; MAP2K6; MAP2K7; MAP3K1; MAP3K7; MAP3K8; MAPK1; MAPK10; MAPK11; MAPK14; MAPK3; MAPK8; MAPK9; MAPKAPK2; MAPKAPK3; MEF2A; MEF2C; MYD88; NFKB1; NFKB2; NFKBIA; NFKBIB; NKIRAS1; NOD1; NOD2; PELI1; PELI2; PELI3; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5D; RELA; RIPK2; RPS6KA1; RPS6KA2; RPS6KA5"
"R-HSA-975871","MyD88 cascade initiated on plasma membrane",0.0647811988638208,0.185111496300608,0.726370421425801,56,"AGER; APP; ATF1; ATF2; BTRC; CHUK; CUL1; DUSP3; DUSP4; DUSP7; ECSIT; FBXW11; FOS; IKBKB; IRAK2; IRAK4; MAP2K1; MAP2K3; MAP2K4; MAP2K6; MAP2K7; MAP3K1; MAP3K7; MAP3K8; MAPK1; MAPK10; MAPK11; MAPK14; MAPK3; MAPK8; MAPK9; MAPKAPK2; MAPKAPK3; MEF2A; MEF2C; MYD88; NFKB1; NFKB2; NFKBIA; NFKBIB; NKIRAS1; NOD1; NOD2; PELI1; PELI2; PELI3; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R5D; RELA; RIPK2; RPS6KA1; RPS6KA2; RPS6KA5"
"R-HSA-1592230","Mitochondrial biogenesis",-0.0671242742176952,0.192562646118775,0.72740157589035,52,"ACSS2; ALAS1; ATF2; ATP5A1; ATP5B; ATP5C1; ATP5D; ATP5E; ATP5F1; ATP5G1; ATP5G2; ATP5G3; ATP5H; ATP5I; ATP5J2; ATP5L; ATP5O; ATP5S; CALM1; CAMK4; CARM1; CHCHD3; CHCHD6; CHD9; CRTC1; CRTC2; CRTC3; CYCS; DNAJC11; ESRRA; GABPA; GABPB1; GLUD1; HDAC3; IDH2; IMMT; MAPK11; MAPK12; MAPK14; MEF2C; MEF2D; MINOS1; MTX1; MTX2; NCOA1; NCOA2; NCOA6; NCOR1; NR1D1; NRF1; PERM1; POLG2"
"R-HSA-176974","Unwinding of DNA",0.143747426069651,0.413018953717736,0.727809580899344,11,"CDC45; GINS1; GINS2; GINS3; MCM2; MCM3; MCM4; MCM5; MCM6; MCM7; MCM8"
"R-HSA-912694","Regulation of IFNA signaling",-0.144518601458232,0.415485848978636,0.727967571365143,11,"IFNAR1; IFNAR2; JAK1; PTPN1; PTPN6; SOCS1; SOCS3; STAT1; STAT2; TYK2; USP18"
"R-HSA-1362300","Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1",0.122648563990285,0.354722498087887,0.729523696475192,15,"CCNA2; CDK1; E2F1; E2F4; E2F5; HDAC1; LIN37; LIN52; LIN54; LIN9; MYBL2; RBBP4; RBL1; RBL2; TFDP1"
"R-HSA-5675482","Regulation of necroptotic cell death",0.13630085825063,0.395847060709135,0.730600329262591,12,"BIRC2; BIRC3; CASP8; CFLAR; FADD; FAS; FASLG; RIPK1; TNFRSF10A; TNFRSF10B; TNFSF10; TRAF2"
"R-HSA-159227","Transport of the SLBP independent Mature mRNA",-0.0865228269920149,0.252966177527977,0.732325919872168,30,"ALYREF; EIF4E; NCBP1; NCBP2; NDC1; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188; NUP205; NUP210; NUP214; NUP35; NUP43; NUP50; NUP54; NUP58; NUP62; NUP85; NUP88; NUP93; NUP98; NUPL2; NXF1; POM121; RAE1; RANBP2; SEH1L"
"R-HSA-170670","Adenylate cyclase inhibitory pathway",-0.129857678652079,0.382748431280201,0.734401187331781,13,"ADCY1; ADCY2; ADCY3; ADCY4; ADCY5; ADCY6; ADCY7; ADCY9; GNAI1; GNAI2; GNAI3; GNAL; GNAT3"
"R-HSA-997269","Inhibition of adenylate cyclase pathway",-0.129857678652079,0.382748431280201,0.734401187331781,13,"ADCY1; ADCY2; ADCY3; ADCY4; ADCY5; ADCY6; ADCY7; ADCY9; GNAI1; GNAI2; GNAI3; GNAL; GNAT3"
"R-HSA-69242","S Phase",0.0601696136336051,0.177485776309114,0.734601515188953,61,"CCNA1; CCNA2; CCND1; CCNE1; CCNE2; CCNH; CDC25A; CDC25B; CDC45; CDC6; CDCA5; CDK2; CDK4; CDK7; CDKN1B; CDT1; CUL1; DNA2; E2F1; E2F4; E2F5; ESCO1; ESCO2; FZR1; GINS1; GINS2; GINS3; LIG1; LIN37; LIN52; LIN54; LIN9; MAX; MCM2; MCM3; MCM4; MCM5; MCM6; MCM7; MCM8; MNAT1; MYC; ORC1; ORC3; ORC4; ORC5; ORC6; PCNA; PDS5A; PDS5B; POLA2; POLD1; POLD2; POLD3; POLE; POLE2; POLE3; POLE4; PRIM1; PRIM2; PSMA1"
"R-HSA-5685938","HDR through Single Strand Annealing (SSA)",0.0763331984496329,0.230359829446426,0.740368754378447,36,"ABL1; ATM; ATR; ATRIP; BARD1; BLM; BRCA1; BRIP1; DNA2; ERCC4; EXO1; HUS1; KAT5; MRE11; NBN; RAD1; RAD17; RAD50; RAD51; RAD52; RAD9A; RAD9B; RBBP8; RFC2; RFC3; RFC4; RFC5; RHNO1; RMI1; RMI2; RPA1; RPA2; RPA3; TOP3A; TOPBP1; WRN"
"R-HSA-5654706","FRS-mediated FGFR3 signaling",0.116983592456799,0.354949897130593,0.741719028498921,15,"FGF1; FGF17; FGF18; FGF2; FGF20; FGF5; FGF9; FGFR3; FRS2; FRS3; GRB2; HRAS; KRAS; NRAS; SOS1"
"R-HSA-1643685","Disease",-0.0589458239726143,0.179415697720592,0.742500916836412,60,"ABCC8; ACAN; ADAM10; ADAM17; ADAMTS10; ADAMTS12; ADAMTS13; ADAMTS14; ADAMTS15; ADAMTS16; ADAMTS17; ADAMTS18; ADAMTS19; ADAMTS2; ADAMTS3; ADAMTS4; ADAMTS5; ADAMTS6; ADAMTS7; ADAMTS8; ADAMTS9; ADAMTSL1; ADAMTSL2; ADAMTSL3; ADAMTSL4; ADAMTSL5; AGGF1; AGK; AGRN; AGTRAP; AKAP9; AKT1; AKT1S1; AKT2; AKT3; ALB; AMN; ANTXR1; ANTXR2; AP1B1; AP1G1; AP1M1; AP1M2; AP1S1; AP1S3; AP2A1; AP2A2; AP2B1; AP2M1; AP2S1; AP3B1; APBB1IP; APC; APH1A; APH1B; APOBEC3G; APP; ARRB1; ARRB2; ATG7"
"R-HSA-8949215","Mitochondrial calcium ion transport",0.0987661401442016,0.300673397495784,0.742546394025519,21,"AKAP1; LETM1; MCU; MCUB; MICU1; MICU2; MICU3; PARL; PHB; PHB2; PMPCA; PMPCB; SLC8A3; SLC8B1; SMDT1; SPG7; STOML2; VDAC1; VDAC2; VDAC3; YME1L1"
"R-HSA-5362517","Signaling by Retinoic Acid",0.075635097773578,0.230372455927851,0.742672306317683,36,"ADH1A; ADH4; AKR1C3; ALDH1A1; ALDH1A2; ALDH1A3; ALDH8A1; CPT1A; CPT1B; CRABP1; CRABP2; CYP26B1; CYP26C1; DHRS3; DHRS4; DHRS9; DLAT; DLD; PDHB; PDHX; PDK1; PDK2; PDK4; PPARD; RARA; RARB; RDH10; RDH11; RDH13; RDH14; RDH16; RDH5; RXRA; RXRB; RXRG; SDR16C5"
"R-HSA-9006931","Signaling by Nuclear Receptors",0.075635097773578,0.230372455927851,0.742672306317683,36,"ADH1A; ADH4; AKR1C3; ALDH1A1; ALDH1A2; ALDH1A3; ALDH8A1; CPT1A; CPT1B; CRABP1; CRABP2; CYP26B1; CYP26C1; DHRS3; DHRS4; DHRS9; DLAT; DLD; PDHB; PDHX; PDK1; PDK2; PDK4; PPARD; RARA; RARB; RDH10; RDH11; RDH13; RDH14; RDH16; RDH5; RXRA; RXRB; RXRG; SDR16C5"
"R-HSA-5358606","Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)",-0.125349272706021,0.382887146485353,0.743381126087983,13,"EXO1; LIG1; MLH1; MSH2; MSH3; PCNA; PMS2; POLD1; POLD2; POLD3; RPA1; RPA2; RPA3"
"R-HSA-1475029","Reversible hydration of carbon dioxide",-0.142446712647988,0.435814135385159,0.743779843031222,10,"CA1; CA12; CA13; CA14; CA2; CA3; CA4; CA5A; CA6; CA9"
"R-HSA-5693537","Resolution of D-Loop Structures",0.0784134109479291,0.240510841729144,0.744402723158415,33,"ATM; BARD1; BLM; BRCA1; BRCA2; BRIP1; DNA2; EME1; EME2; EXO1; GEN1; KAT5; MRE11; MUS81; NBN; PALB2; RAD50; RAD51; RAD51AP1; RAD51B; RAD51C; RAD51D; RBBP8; RMI1; RMI2; RTEL1; SLX1A; SLX4; SPIDR; TOP3A; WRN; XRCC2; XRCC3"
"R-HSA-6811440","Retrograde transport at the Trans-Golgi-Network",-0.0666975569297057,0.20467197250348,0.744518643283105,46,"ARFIP2; ARFRP1; ARL1; COG1; COG2; COG3; COG4; COG5; COG6; COG7; COG8; GCC1; GCC2; GOLGA1; GOLGA4; IGF2R; M6PR; NAA30; NAA35; NAA38; NAPA; NAPB; NAPG; NSF; PLIN3; RAB43; RAB6A; RAB6B; RABEPK; RGP1; RHOBTB3; RIC1; SCOC; STX10; STX16; STX6; SYS1; TGOLN2; TMF1; USP6NL; VAMP3; VAMP4; VPS52; VPS53; VPS54; VTI1A"
"R-HSA-1799339","SRP-dependent cotranslational protein targeting to membrane",0.0617623849493082,0.190271700873942,0.745483068008525,53,"DDOST; FAU; RPL10A; RPL12; RPL13; RPL13A; RPL14; RPL15; RPL17; RPL18; RPL18A; RPL19; RPL21; RPL22L1; RPL23A; RPL26; RPL26L1; RPL27A; RPL28; RPL29; RPL3; RPL30; RPL31; RPL32; RPL34; RPL35; RPL35A; RPL36; RPL36AL; RPL37; RPL38; RPL39L; RPL3L; RPL4; RPL41; RPL5; RPL7; RPL7A; RPL8; RPL9; RPLP0; RPLP2; RPN1; RPN2; RPS10; RPS11; RPS12; RPS13; RPS14; RPS15; RPS15A; RPS16; RPS18"
"R-HSA-192823","Viral mRNA Translation",0.0647187945323143,0.199841377127166,0.746050976369476,48,"DNAJC3; FAU; GRSF1; RPL10A; RPL12; RPL13; RPL13A; RPL14; RPL15; RPL17; RPL18; RPL18A; RPL19; RPL21; RPL22L1; RPL23A; RPL26; RPL26L1; RPL27A; RPL28; RPL29; RPL3; RPL30; RPL31; RPL32; RPL34; RPL35; RPL35A; RPL36; RPL36AL; RPL37; RPL38; RPL39L; RPL3L; RPL4; RPL41; RPL5; RPL7; RPL7A; RPL8; RPL9; RPLP0; RPLP2; RPS10; RPS11; RPS12; RPS13; RPS14"
"R-HSA-2129379","Molecules associated with elastic fibres",-0.0859583341776441,0.266597622014932,0.74712905427791,27,"BMP4; BMP7; EFEMP1; EFEMP2; FBLN1; FBLN2; FBLN5; GDF5; ITGA8; ITGAV; ITGB1; ITGB3; ITGB5; ITGB6; ITGB8; LTBP1; LTBP2; LTBP3; LTBP4; MFAP1; MFAP2; MFAP3; MFAP4; TGFB1; TGFB2; TGFB3; VTN"
"R-HSA-181431","Acetylcholine binding and downstream events",0.122633450193966,0.380975332405085,0.74753344314437,13,"CHRNA1; CHRNA2; CHRNA3; CHRNA4; CHRNA5; CHRNA6; CHRNA7; CHRNB2; CHRNB3; CHRNB4; CHRND; CHRNE; CHRNG"
"R-HSA-622327","Postsynaptic nicotinic acetylcholine receptors",0.122633450193966,0.380975332405085,0.74753344314437,13,"CHRNA1; CHRNA2; CHRNA3; CHRNA4; CHRNA5; CHRNA6; CHRNA7; CHRNB2; CHRNB3; CHRNB4; CHRND; CHRNE; CHRNG"
"R-HSA-629602","Activation of Nicotinic Acetylcholine Receptors",0.122633450193966,0.380975332405085,0.74753344314437,13,"CHRNA1; CHRNA2; CHRNA3; CHRNA4; CHRNA5; CHRNA6; CHRNA7; CHRNB2; CHRNB3; CHRNB4; CHRND; CHRNE; CHRNG"
"R-HSA-5357769","Caspase activation via extrinsic apoptotic signalling pathway",0.089915303566679,0.281558050975844,0.74946182164886,24,"APPL1; CASP3; CASP8; CASP9; CD14; CFLAR; DAPK1; DAPK2; DAPK3; DCC; FADD; FAS; FASLG; LY96; RIPK1; TICAM1; TICAM2; TLR4; TNFRSF10A; TNFRSF10B; TNFSF10; TRAF2; UNC5A; UNC5B"
"R-HSA-381676","Glucagon-like Peptide-1 (GLP1) regulates insulin secretion",0.0745889538600791,0.233642478995108,0.749541512493422,35,"ADCY5; ADCY6; GCG; GLP1R; GNAS; GNB1; GNB2; GNB3; GNB4; GNB5; GNG10; GNG11; GNG12; GNG2; GNG3; GNG4; GNG5; GNG7; GNGT2; IQGAP1; ITPR1; ITPR2; ITPR3; KCNB1; KCNC2; KCNG2; KCNS3; PRKACB; PRKAR1A; PRKAR1B; PRKAR2A; PRKAR2B; RAP1A; RAPGEF3; RAPGEF4"
"R-HSA-1855183","Synthesis of IP2, IP, and Ins in the cytosol",-0.121703981438436,0.382994563841322,0.750659806950493,13,"IMPA1; IMPA2; INPP1; INPP4A; INPP4B; INPP5A; INPP5B; INPP5J; ISYNA1; MIOX; MTMR7; MTMR9; SYNJ1"
"R-HSA-4085001","Sialic acid metabolism",-0.0816125829962593,0.257326553033188,0.751125462408012,29,"CMAS; CTSA; GLB1; GNE; NANP; NANS; NEU1; NEU3; NEU4; NPL; SLC17A5; SLC35A1; ST3GAL1; ST3GAL3; ST3GAL4; ST3GAL5; ST3GAL6; ST6GAL1; ST6GAL2; ST6GALNAC1; ST6GALNAC2; ST6GALNAC3; ST6GALNAC4; ST6GALNAC6; ST8SIA1; ST8SIA2; ST8SIA4; ST8SIA5; ST8SIA6"
"R-HSA-174490","Membrane binding and targetting of GAG proteins",-0.124796763034878,0.398508336316748,0.754159311471154,12,"MVB12A; MVB12B; NMT2; TSG101; UBA52; UBAP1; UBC; VPS28; VPS37A; VPS37B; VPS37C; VPS37D"
"R-HSA-174495","Synthesis And Processing Of GAG, GAGPOL Polyproteins",-0.124796763034878,0.398508336316748,0.754159311471154,12,"MVB12A; MVB12B; NMT2; TSG101; UBA52; UBAP1; UBC; VPS28; VPS37A; VPS37B; VPS37C; VPS37D"
"R-HSA-174048","APC/C:Cdc20 mediated degradation of Cyclin B",0.101413659965674,0.324577685172754,0.75470004950123,18,"ANAPC1; ANAPC10; ANAPC11; ANAPC15; ANAPC16; ANAPC2; ANAPC4; ANAPC5; ANAPC7; CCNB1; CDC16; CDC26; CDC27; CDK1; UBA52; UBC; UBE2D1; UBE2E1"
"R-HSA-2122948","Activated NOTCH1 Transmits Signal to the Nucleus",-0.0830122243975102,0.266631992977396,0.755544956357941,27,"ADAM10; ADAM17; APH1A; APH1B; ARRB1; ARRB2; CNTN1; DLK1; DLL1; DNER; DTX1; DTX2; DTX4; ITCH; JAG1; JAG2; MIB1; MIB2; NCSTN; NEURL1; NEURL1B; NOTCH1; NUMB; PSEN1; PSEN2; UBA52; UBC"
"R-HSA-8935690","Digestion",-0.12387816101037,0.398536798312167,0.755928015314933,12,"AMY2A; AMY2B; CEL; CHIA; CHIT1; CLPS; GUCA2A; GUCY2C; LCT; MGAM; PNLIPRP3; TREH"
"R-HSA-1852241","Organelle biogenesis and maintenance",0.0535934479187152,0.173386403711717,0.757246729115582,64,"ACSS2; ACTR1A; AHI1; AKAP9; ALAS1; ALMS1; ARF4; ARL13B; ARL3; ASAP1; ATAT1; ATF2; ATP5A1; ATP5B; ATP5C1; ATP5D; ATP5E; ATP5F1; ATP5G1; ATP5G2; ATP5G3; ATP5H; ATP5I; ATP5J2; ATP5L; ATP5O; ATP5S; B9D1; B9D2; BBIP1; BBS1; BBS10; BBS12; BBS2; BBS4; BBS5; BBS7; BBS9; C2CD3; CALM1; CAMK4; CARM1; CC2D2A; CCP110; CCT2; CCT3; CCT4; CCT5; CCT8; CDK1; CDK5RAP2; CENPJ; CEP131; CEP135; CEP152; CEP162; CEP164; CEP192; CEP250; CEP290; CEP41; CEP57; CEP63; CEP70"
"R-HSA-70326","Glucose metabolism",0.0561632432554328,0.182023364238559,0.757664135196295,58,"ADPGK; ALDOB; ALDOC; BPGM; ENO1; ENO2; ENO3; FBP1; FBP2; G6PC2; G6PC3; GAPDH; GCK; GCKR; GNPDA1; GNPDA2; GOT1; GOT2; GPI; HK1; HK2; MDH1; MDH2; NDC1; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188; NUP205; NUP210; NUP214; NUP35; NUP43; NUP50; NUP54; NUP58; NUP62; NUP85; NUP88; NUP93; NUP98; NUPL2; PC; PCK1; PCK2; PFKFB2; PFKFB3; PFKFB4; PFKL; PFKM; PFKP; PGAM1; PGM2L1; PGP; PKLR; PKM"
"R-HSA-168325","Viral Messenger RNA Synthesis",-0.069243983626785,0.225043413235146,0.758316958854396,38,"GTF2F1; GTF2F2; NDC1; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188; NUP205; NUP210; NUP214; NUP35; NUP43; NUP50; NUP54; NUP58; NUP62; NUP85; NUP88; NUP93; NUP98; NUPL2; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; POM121; RAE1; RANBP2; SEH1L"
"R-HSA-977068","Termination of O-glycan biosynthesis",0.0947852645238635,0.308186022478182,0.758418219302096,20,"MUC1; MUC12; MUC13; MUC15; MUC16; MUC20; MUC21; MUC3A; MUC4; MUC5B; MUC6; MUC7; MUCL1; ST3GAL1; ST3GAL3; ST3GAL4; ST6GAL1; ST6GALNAC2; ST6GALNAC3; ST6GALNAC4"
"R-HSA-8875360","InlB-mediated entry of Listeria monocytogenes into host cell",0.121715338189523,0.396543010099799,0.758888223052165,12,"CBL; EPS15; GRB2; HGS; MET; SH3GL1; SH3GL2; SH3GL3; STAM; STAM2; UBA52; UBC"
"R-HSA-72203","Processing of Capped Intron-Containing Pre-mRNA",0.0560279231092218,0.183600546123674,0.76024271749966,57,"ALYREF; AQR; BCAS2; BUD31; CASC3; CCAR1; CD2BP2; CDC40; CDC5L; CHERP; CHTOP; CLP1; CPSF1; CPSF2; CPSF3; CPSF4; CPSF7; CRNKL1; CSTF1; CSTF2T; CSTF3; CTNNBL1; CWC15; CWC22; CWC27; DDX23; DDX39A; DDX39B; DDX42; DDX46; DDX5; DHX15; DHX16; DHX38; DNAJC8; EFTUD2; EIF4A3; EIF4E; ELAVL2; FIP1L1; FUS; FYTTD1; GCFC2; GLE1; GTF2F1; GTF2F2; HNRNPA1; HNRNPA3; HNRNPF; HNRNPH1; HNRNPK; HNRNPL; HNRNPM; HNRNPR; HNRNPU; HNRNPUL1; HSPA8"
"R-HSA-163210","Formation of ATP by chemiosmotic coupling",0.108127300438687,0.355288461250667,0.760871425114789,15,"ATP5A1; ATP5B; ATP5C1; ATP5D; ATP5E; ATP5F1; ATP5G1; ATP5G2; ATP5G3; ATP5H; ATP5I; ATP5J2; ATP5L; ATP5O; ATP5S"
"R-HSA-2465910","MASTL Facilitates Mitotic Progression",0.131968845795741,0.433792126437006,0.760959226086807,10,"ARPP19; CCNB1; CDK1; ENSA; MASTL; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PPP2R2D"
"R-HSA-2187338","Visual phototransduction",0.058432401379978,0.192118768140377,0.761015685269588,52,"ABCA4; AGRN; AKR1B10; AKR1C1; AKR1C3; APOA1; APOA2; APOB; APOC3; APOM; BCO1; BCO2; CALM1; CAMKMT; CLPS; CNGA1; CYP4V2; DHRS3; DHRS9; FNTA; FNTB; GNAT1; GNB1; GNB5; GPC1; GPC2; GPC5; GPC6; GRK1; GRK4; GRK7; GUCA1A; GUCA1B; GUCA1C; HSD17B1; HSD17B6; HSPG2; LDLR; LPL; LRAT; LRP1; LRP12; LRP8; METAP1; METAP2; MYO7A; NAPEPLD; NMT1; NMT2; OPN1SW; PDE6A; PDE6B"
"R-HSA-2172127","DAP12 interactions",-0.0731332943954499,0.241374466635176,0.761899867012183,33,"B2M; CD300E; CD300LB; FYN; GRAP2; GRB2; HLA-B; HLA-C; HLA-E; HRAS; KLRC2; KLRD1; KLRK1; KRAS; LAT; LCP2; NRAS; PIK3CA; PIK3CB; PIK3R1; PIK3R2; PLCG1; PLCG2; RAC1; SHC1; SIGLEC14; SIRPB1; SOS1; SYK; TREM1; TREM2; VAV2; VAV3"
"R-HSA-1502540","Signaling by Activin",-0.12037016366049,0.398642912763472,0.762690301165253,12,"ACVR1B; ACVR1C; ACVR2A; ACVR2B; DRAP1; FST; FSTL3; INHBA; INHBB; SMAD2; SMAD3; SMAD4"
"R-HSA-73884","Base Excision Repair",0.0701871060574594,0.237115680635984,0.767227296789972,34,"ADPRHL2; APEX1; LIG1; LIG3; MBD4; MPG; MUTYH; NEIL1; NEIL2; PARG; PARP1; PARP2; PCNA; PNKP; POLB; POLD1; POLD2; POLD3; POLE; POLE2; POLE3; POLE4; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3; SMUG1; TDG; UNG; XRCC1"
"R-HSA-73933","Resolution of Abasic Sites (AP sites)",0.0701871060574594,0.237115680635984,0.767227296789972,34,"ADPRHL2; APEX1; LIG1; LIG3; MBD4; MPG; MUTYH; NEIL1; NEIL2; PARG; PARP1; PARP2; PCNA; PNKP; POLB; POLD1; POLD2; POLD3; POLE; POLE2; POLE3; POLE4; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3; SMUG1; TDG; UNG; XRCC1"
"R-HSA-9008059","Interleukin-37 signaling",0.0934804866795724,0.316197882507763,0.767505639465335,19,"CASP1; IL18BP; IL18R1; PTPN12; PTPN13; PTPN14; PTPN18; PTPN2; PTPN20; PTPN23; PTPN4; PTPN5; PTPN6; PTPN7; PTPN9; SIGIRR; SMAD3; STAT3; TBK1"
"R-HSA-6790901","rRNA modification in the nucleus and cytosol",0.0561583972707616,0.19034095439908,0.767962512409018,53,"BMS1; DCAF13; DDX49; DHX37; DIEXF; DIMT1; EMG1; FBL; FCF1; GAR1; HEATR1; IMP3; IMP4; KRR1; MPHOSPH10; NAT10; NHP2; NOC4L; NOL11; NOL6; NOP10; NOP14; NOP2; NOP56; NOP58; PDCD11; PNO1; PWP2; RCL1; RPS14; RPS2; RPS6; RPS7; RPS9; RRP7A; SNU13; TBL3; THUMPD1; TRMT112; TSR3; UTP11; UTP14C; UTP15; UTP18; UTP20; UTP3; UTP4; UTP6; WDR3; WDR36; WDR43; WDR46; WDR75"
"R-HSA-70268","Pyruvate metabolism",-0.0832035747013188,0.282739000233117,0.768546273504709,24,"BSG; DLAT; DLD; GLO1; HAGH; LDHA; LDHAL6A; LDHAL6B; LDHB; LDHC; MPC1; MPC2; PDHB; PDHX; PDK1; PDK2; PDK4; PDP1; PDPR; PPARD; RXRA; SLC16A1; SLC16A3; SLC16A8"
"R-HSA-72766","Translation",-0.053636638575094,0.182474773603146,0.768803736773928,58,"AARS; AARS2; AIMP1; AIMP2; APEH; AURKAIP1; CARS; CARS2; CHCHD1; DAP3; DARS; DARS2; DDOST; EARS2; EEF1A2; EEF1B2; EEF1D; EEF1E1; EEF1G; EEF2; EIF2B1; EIF2B2; EIF2B3; EIF2B5; EIF2S1; EIF2S2; EIF3A; EIF3B; EIF3C; EIF3D; EIF3E; EIF3F; EIF3G; EIF3H; EIF3I; EIF3J; EIF3K; EIF3L; EIF3M; EIF4A1; EIF4A2; EIF4B; EIF4E; EIF4G1; EIF4H; EIF5; EIF5B; EPRS; ERAL1; ETF1; FARS2; FARSA; FARSB; FAU; GARS; GFM1; GFM2; GSPT1"
"R-HSA-400685","Sema4D in semaphorin signaling",-0.086508091129224,0.29521975428968,0.769499618330581,22,"ARHGAP35; ARHGEF11; ARHGEF12; ERBB2; LIMK1; LIMK2; MET; MYH10; MYH11; MYH14; MYH9; MYL12B; MYL6; MYL9; PLXNB1; RAC1; RHOB; RHOC; ROCK1; ROCK2; RRAS; SEMA4D"
"R-HSA-5626467","RHO GTPases activate IQGAPs",0.121353446115561,0.414160443438456,0.769513964427332,11,"CALM1; CDC42; CDH1; CLIP1; CTNNA1; CTNNB1; IQGAP1; IQGAP2; IQGAP3; MEN1; RAC1"
"R-HSA-4615885","SUMOylation of DNA replication proteins",-0.0644724475567574,0.222186148440391,0.77168380031158,39,"AURKA; AURKB; BIRC5; INCENP; NDC1; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188; NUP205; NUP210; NUP214; NUP35; NUP43; NUP50; NUP54; NUP58; NUP62; NUP85; NUP88; NUP93; NUP98; NUPL2; PCNA; PIAS3; PIAS4; POM121; RAE1; RANBP2; RANGAP1; SEH1L; SUMO1; SUMO2; SUMO3; TOP1; TOP2B; UBE2I"
"R-HSA-162658","Golgi Cisternae Pericentriolar Stack Reorganization",0.109556580254431,0.381526451494228,0.773994940954615,13,"BLZF1; CCNB1; CCNB2; CDK1; GOLGA2; GORASP1; GORASP2; MAPK1; MAPK3; PLK1; RAB1A; RAB2A; USO1"
"R-HSA-1169408","ISG15 antiviral mechanism",0.0513112593757333,0.17904393445481,0.774430300372523,60,"ARIH1; DDX58; EIF2AK2; EIF4A1; EIF4A2; EIF4A3; EIF4E; EIF4E2; EIF4E3; EIF4G1; EIF4G2; EIF4G3; FLNB; IFIT1; IRF3; ISG15; JAK1; KPNA1; KPNA2; KPNA3; KPNA4; KPNA5; KPNA7; KPNB1; MAPK3; MX1; MX2; NDC1; NEDD4; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188; NUP205; NUP210; NUP214; NUP35; NUP43; NUP50; NUP54; NUP58; NUP62; NUP85; NUP88; NUP93; NUP98; NUPL2; PIN1; PLCG1; POM121; PPM1B; RAE1; RANBP2; SEH1L; STAT1; TRIM25; UBA52; UBA7"
"R-HSA-1169410","Antiviral mechanism by IFN-stimulated genes",0.0513112593757333,0.17904393445481,0.774430300372523,60,"ARIH1; DDX58; EIF2AK2; EIF4A1; EIF4A2; EIF4A3; EIF4E; EIF4E2; EIF4E3; EIF4G1; EIF4G2; EIF4G3; FLNB; IFIT1; IRF3; ISG15; JAK1; KPNA1; KPNA2; KPNA3; KPNA4; KPNA5; KPNA7; KPNB1; MAPK3; MX1; MX2; NDC1; NEDD4; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188; NUP205; NUP210; NUP214; NUP35; NUP43; NUP50; NUP54; NUP58; NUP62; NUP85; NUP88; NUP93; NUP98; NUPL2; PIN1; PLCG1; POM121; PPM1B; RAE1; RANBP2; SEH1L; STAT1; TRIM25; UBA52; UBA7"
"R-HSA-2173782","Binding and Uptake of Ligands by Scavenger Receptors",-0.0801090200630726,0.282775497797501,0.776950342727006,24,"ALB; AMBP; APOA1; APOB; APOL1; CALR; CD163; CD36; COL1A1; COL1A2; COL3A1; COL4A1; COL4A2; COLEC11; COLEC12; FTH1; FTL; HBB; HP; HPR; HPX; HSP90AA1; HSP90B1; HSPH1"
"R-HSA-2160916","Hyaluronan uptake and degradation",-0.117606865402951,0.416421237049555,0.77761930926265,11,"CD44; CHP1; GUSB; HEXA; HEXB; HMMR; HYAL1; HYAL3; LYVE1; SLC9A1; STAB2"
"R-HSA-2142845","Hyaluronan metabolism",0.0966955963676467,0.344425434129323,0.778906263182005,16,"ABCC5; CD44; CEMIP; CHP1; GUSB; HAS1; HAS2; HAS3; HEXA; HEXB; HMMR; HYAL1; HYAL3; LYVE1; SLC9A1; STAB2"
"R-HSA-372708","p130Cas linkage to MAPK signaling for integrins",-0.1002135721942,0.357110668316255,0.778999347368055,15,"APBB1IP; BCAR1; CRK; FGA; FGB; FGG; FN1; ITGA2B; ITGB3; PTK2; RAP1A; RAP1B; SRC; TLN1; VWF"
"R-HSA-5213460","RIPK1-mediated regulated necrosis",-0.103602073457682,0.369543859733253,0.779208054546588,14,"BIRC2; BIRC3; CASP8; CFLAR; FADD; FAS; FASLG; MLKL; RIPK1; RIPK3; TNFRSF10A; TNFRSF10B; TNFSF10; TRAF2"
"R-HSA-5218859","Regulated Necrosis",-0.103602073457682,0.369543859733253,0.779208054546588,14,"BIRC2; BIRC3; CASP8; CFLAR; FADD; FAS; FASLG; MLKL; RIPK1; RIPK3; TNFRSF10A; TNFRSF10B; TNFSF10; TRAF2"
"R-HSA-164952","The role of Nef in HIV-1 replication and disease pathogenesis",-0.0773851003757496,0.277113413532224,0.780049708056878,25,"AP1B1; AP1G1; AP1M1; AP1M2; AP1S1; AP1S3; AP2A1; AP2A2; AP2B1; AP2M1; AP2S1; ATP6V1H; B2M; CD247; CD28; CD4; CD8B; DOCK2; ELMO1; FYN; HCK; HLA-A; PACS1; PAK2; RAC1"
"R-HSA-400042","Adrenaline,noradrenaline inhibits insulin secretion",0.0769545078808963,0.276194814024684,0.780533381298666,25,"ADCY5; ADCY6; ADRA2A; ADRA2C; CACNA1C; CACNA1D; CACNA2D2; CACNB2; CACNB3; GNAI1; GNAI2; GNB1; GNB2; GNB3; GNB4; GNB5; GNG10; GNG11; GNG12; GNG2; GNG3; GNG4; GNG5; GNG7; GNGT2"
"R-HSA-450302","activated TAK1 mediates p38 MAPK activation",0.0959216835082055,0.344450837627618,0.78064611231502,16,"IRAK2; MAP2K3; MAP2K6; MAP3K7; MAPK11; MAPK14; MAPKAPK2; MAPKAPK3; NOD1; NOD2; RIPK2; TAB1; TAB2; TRAF6; UBE2N; UBE2V1"
"R-HSA-5578768","Physiological factors",-0.115876029999592,0.416472773168427,0.780834313528843,11,"CORIN; HIPK1; HIPK2; KAT2B; NKX2-5; NPPA; NPPC; NPR1; NPR2; TBX5; WWTR1"
"R-HSA-6802957","Oncogenic MAPK signaling",0.0478830821371247,0.172117523493571,0.780858892385386,65,"AGGF1; AGK; AGTRAP; AKAP9; AP3B1; APBB1IP; ARRB1; ARRB2; ATG7; BCL2L11; BRAF; BRAP; CLCN6; CNKSR1; CSK; DAB2IP; ESRP1; FAM114A2; FAM131B; FGA; FGB; FGG; FN1; FXR1; HRAS; IQGAP1; ITGA2B; ITGB3; JAK2; KDM7A; KIAA1549; KRAS; KSR1; KSR2; LMNA; MAP2K1; MAP2K2; MAP3K11; MAPK1; MAPK3; MARK3; MPRIP; NF1; NRAS; PAPD7; PAPSS1; PEBP1; PHB; QKI; RAF1; RAP1A; RAP1B; RASA1; RASA2; RASA3; RASA4; RASAL1; RASAL2; RASAL3; SND1; SPRED1; SPRED2; SPRED3; SRC; TLN1"
"R-HSA-2022377","Metabolism of Angiotensinogen to Angiotensins",0.115232454166713,0.414445567089251,0.780981637189796,11,"ACE; AGT; ANPEP; CMA1; CPA3; CTSD; CTSG; CTSZ; ENPEP; MME; REN"
"R-HSA-191273","Cholesterol biosynthesis",0.0817890406332301,0.294236957132478,0.781035404616181,22,"ACAT2; ARV1; CYP51A1; DHCR24; DHCR7; FDFT1; FDPS; GGPS1; HMGCR; HMGCS1; HSD17B7; IDI1; IDI2; LBR; LSS; MSMO1; MVD; MVK; PLPP6; PMVK; SC5D; SQLE"
"R-HSA-418555","G alpha (s) signalling events",0.0526955775753575,0.190381592046497,0.781941938089068,53,"ADCY1; ADCY2; ADCY3; ADCY4; ADCY5; ADCY6; ADCY7; ADCY9; ADCYAP1; ADCYAP1R1; ADM; ADM2; ADORA2A; ADORA2B; ADRB1; ADRB2; ARRB1; ARRB2; CALCA; CALCB; CALCRL; CGA; CRHR1; CRHR2; DRD1; DRD5; FSHR; GCG; GLP1R; GLP2R; GNAI1; GNAI2; GNAI3; GNAL; GNAS; GNAT3; GNAZ; GNB1; GNB2; GNB3; GNB4; GNB5; GNG10; GNG11; GNG12; GNG2; GNG3; GNG4; GNG5; GNG7; GNGT2; GPBAR1; GPHA2"
"R-HSA-428157","Sphingolipid metabolism",0.0495710794516262,0.180559639998831,0.783668664632208,59,"ACER2; ACER3; ALDH3A2; ALDH3B1; ALDH3B2; ARSA; ARSB; ARSG; ARSI; ARSJ; ARSK; ASAH1; ASAH2; B3GALNT1; B4GALNT1; CERK; CERS1; CERS2; CERS3; CERS4; CERS5; CERS6; COL4A3BP; CPTP; CSNK1G2; CTSA; DEGS1; DEGS2; ENPP7; ESYT1; ESYT2; ESYT3; FA2H; GALC; GBA; GBA2; GLB1; GLB1L; GLTP; GM2A; HEXA; HEXB; KDSR; NEU1; NEU3; NEU4; ORMDL1; ORMDL2; ORMDL3; PLPP1; PLPP2; PLPP3; PPM1L; PRKD1; PRKD2; PRKD3; PSAP; SAMD8; SGMS1"
"R-HSA-2173789","TGF-beta receptor signaling activates SMADs",-0.0728783067399792,0.266736191344224,0.784682249511243,27,"BAMBI; CBL; FKBP1A; FURIN; MTMR4; NEDD4L; NEDD8; PMEPA1; PPP1CB; PPP1R15A; SMAD2; SMAD3; SMAD4; SMURF1; SMURF2; STRAP; STUB1; TGFB1; TGFBR1; TGFBR2; UBA52; UBC; UBE2M; UCHL5; USP15; XPO1; ZFYVE9"
"R-HSA-163125","Post-translational modification: synthesis of GPI-anchored proteins",0.0497511641933022,0.183670099808402,0.786489158869343,57,"ALPL; ART3; ART4; BST1; CD109; CD52; CEACAM5; CEACAM7; CNTN3; CNTN4; CNTN5; CPM; DPM1; DPM2; FCGR3B; FOLR2; GPAA1; GPLD1; LSAMP; LY6D; LY6E; LY6G6C; LY6H; LY6K; LYPD1; LYPD2; LYPD3; LYPD5; LYPD6B; MDGA1; MELTF; MSLN; NEGR1; NRN1; NRN1L; NTM; NTNG1; NTNG2; OPCML; OTOA; PGAP1; PIGB; PIGC; PIGF; PIGG; PIGH; PIGK; PIGL; PIGM; PIGN; PIGO; PIGP; PIGQ; PIGS; PIGT; PIGU; PIGV"
"R-HSA-389977","Post-chaperonin tubulin folding pathway",0.0834690212019513,0.30849832474669,0.786725189191355,20,"ARL2; TBCA; TBCB; TBCC; TBCD; TBCE; TUBA1A; TUBA1B; TUBA1C; TUBA3C; TUBA3E; TUBA4A; TUBA8; TUBAL3; TUBB1; TUBB2A; TUBB2B; TUBB3; TUBB4A; TUBB6"
"R-HSA-6804756","Regulation of TP53 Activity through Phosphorylation",0.0476395352458712,0.17619603943523,0.786869452583388,62,"ATM; ATR; ATRIP; AURKA; AURKB; BARD1; BLM; BRCA1; BRIP1; CCNA1; CCNA2; CDK2; CDK5R1; CHEK1; CHEK2; CSNK2A2; CSNK2B; DNA2; DYRK2; EXO1; HIPK1; HIPK2; HUS1; KAT5; MAPK11; MAPK14; MAPKAPK5; MDM2; MDM4; MRE11; NBN; NOC2L; NUAK1; PIN1; PLK3; PRKAA1; PRKAA2; PRKAB1; PRKAB2; PRKAG1; PRKAG2; RAD1; RAD17; RAD50; RAD9A; RAD9B; RBBP8; RFC2; RFC3; RFC4; RFC5; RHNO1; RMI1; RMI2; RPA1; RPA2; RPA3; SSRP1; STK11; SUPT16H; TAF10; TAF11"
"R-HSA-975956","Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)",0.0489609451218872,0.186959160144636,0.793413628353843,55,"EIF4G1; ETF1; FAU; GSPT1; NCBP1; NCBP2; PABPC1; RPL10A; RPL12; RPL13; RPL13A; RPL14; RPL15; RPL17; RPL18; RPL18A; RPL19; RPL21; RPL22L1; RPL23A; RPL26; RPL26L1; RPL27A; RPL28; RPL29; RPL3; RPL30; RPL31; RPL32; RPL34; RPL35; RPL35A; RPL36; RPL36AL; RPL37; RPL38; RPL39L; RPL3L; RPL4; RPL41; RPL5; RPL7; RPL7A; RPL8; RPL9; RPLP0; RPLP2; RPS10; RPS11; RPS12; RPS13; RPS14; RPS15; RPS15A; RPS16"
"R-HSA-975634","Retinoid metabolism and transport",0.0620321665250861,0.240804390819797,0.796712567225216,33,"AGRN; AKR1B10; AKR1C1; AKR1C3; APOA1; APOA2; APOB; APOC3; APOM; BCO1; BCO2; CLPS; GPC1; GPC2; GPC5; GPC6; HSPG2; LDLR; LPL; LRAT; LRP1; LRP12; LRP8; PLB1; RBP1; RBP4; RDH11; RETSAT; SDC1; SDC2; SDC3; SDC4; TTR"
"R-HSA-2173793","Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer",0.0584948442401132,0.227534503735083,0.797116086835223,37,"CCNC; CCNK; CCNT1; CCNT2; CDK8; CDK9; CDKN2B; E2F4; E2F5; HDAC1; JUNB; MEN1; MYC; NCOR1; NEDD4L; PARP1; PPM1A; RBL1; RNF111; SERPINE1; SKI; SKIL; SMAD2; SMAD3; SMAD4; SMURF2; SNW1; SP1; TFDP1; TGIF1; TGIF2; TRIM33; UBA52; UBC; UBE2D1; UBE2D3; WWTR1"
"R-HSA-8978934","Metabolism of cofactors",0.0857430515582411,0.334500963750976,0.797695065887289,17,"AKT1; CALM1; COQ2; COQ3; COQ5; COQ6; COQ7; COQ9; DHFR; GCH1; HSP90AA1; NOS3; PDSS1; PDSS2; PRKG2; PTS; SPR"
"R-HSA-157118","Signaling by NOTCH",0.0458397277639409,0.179099868738495,0.797993255457858,60,"ADAM10; ADAM17; AGO1; AGO2; AGO3; AGO4; APH1A; APH1B; ARRB1; ARRB2; ATP2A1; ATP2A2; ATP2A3; B4GALT1; CCNC; CCND1; CDK8; CNTN1; CUL1; DLK1; DLL1; DNER; DTX1; DTX2; DTX4; E2F1; EGF; EGFR; ELF3; EP300; FABP7; FBXW7; FCER2; FURIN; GZMB; HDAC1; HDAC10; HDAC11; HDAC2; HDAC3; HDAC4; HDAC5; HDAC7; HDAC9; HES1; HES5; HEY1; HEY2; HEYL; HIF1A; IKZF1; ITCH; JAG1; JAG2; KAT2A; KAT2B; LFNG; MAML1; MAML2; MAML3"
"R-HSA-204005","COPII (Coat Protein 2) Mediated Vesicle Transport",-0.0467001378250771,0.182494413666561,0.798028827389149,58,"ANKRD28; AREG; BET1; CD59; CNIH1; CNIH2; CNIH3; CSNK1D; CTSC; CTSZ; F5; FOLR1; GOLGA2; GORASP1; GOSR2; GRIA1; LMAN1; LMAN1L; LMAN2; LMAN2L; MCFD2; NAPA; NAPB; NAPG; NSF; PPP6C; PPP6R1; PREB; RAB1A; SAR1B; SCFD1; SEC13; SEC16A; SEC16B; SEC22A; SEC22C; SEC23IP; SEC24A; SEC24B; SEC24C; SEC24D; SERPINA1; STX17; STX5; TBC1D20; TFG; TGFA; TMED10; TMED2; TRAPPC10; TRAPPC2L; TRAPPC3; TRAPPC4; TRAPPC5; TRAPPC6B; TRAPPC9; USO1; YKT6"
"R-HSA-1181150","Signaling by NODAL",0.0851147706447093,0.334519250511261,0.799156361954221,17,"ACVR1B; ACVR1C; ACVR2A; ACVR2B; CER1; DAND5; DRAP1; FOXO3; FURIN; LEFTY1; LEFTY2; NODAL; PCSK6; SMAD2; SMAD3; SMAD4; TDGF1"
"R-HSA-379724","tRNA Aminoacylation",-0.0541613298342239,0.214200445234645,0.800381432425777,42,"AARS; AARS2; AIMP1; AIMP2; CARS; CARS2; DARS; DARS2; EARS2; EEF1E1; EPRS; FARS2; FARSA; FARSB; GARS; HARS; HARS2; IARS; IARS2; KARS; LARS; LARS2; MARS; MARS2; NARS; NARS2; PARS2; PPA1; PPA2; QARS; RARS; RARS2; SARS; SARS2; TARS; TARS2; VARS; VARS2; WARS; WARS2; YARS; YARS2"
"R-HSA-199992","trans-Golgi Network Vesicle Budding",-0.0446112350679835,0.176566401903869,0.800531100727063,62,"ACBD3; AP1B1; AP1G1; AP1G2; AP1M1; AP1M2; AP1S1; AP1S3; AP3B1; AP3S1; AP4B1; AP4E1; AP4M1; AP4S1; APP; ARRB1; BLOC1S1; BLOC1S4; BLOC1S6; CHMP2A; CLINT1; CLTA; CLTB; CLTC; CLVS1; CLVS2; CPD; CTSZ; DNAJC6; DNASE2; DNM2; DTNBP1; FTH1; FTL; GAK; GBF1; GNS; GOLGB1; HGS; HIP1R; HSPA8; IGF2R; M6PR; NAPA; PICALM; PIK3C2A; PUM1; RAB5C; SH3D19; SH3GL2; SNAP23; SNAPIN; SNX2; SNX5; SNX9; SORT1; STX4; TFRC; TGOLN2; TPD52; TPD52L1; TXNDC5"
"R-HSA-421837","Clathrin derived vesicle budding",-0.0446112350679835,0.176566401903869,0.800531100727063,62,"ACBD3; AP1B1; AP1G1; AP1G2; AP1M1; AP1M2; AP1S1; AP1S3; AP3B1; AP3S1; AP4B1; AP4E1; AP4M1; AP4S1; APP; ARRB1; BLOC1S1; BLOC1S4; BLOC1S6; CHMP2A; CLINT1; CLTA; CLTB; CLTC; CLVS1; CLVS2; CPD; CTSZ; DNAJC6; DNASE2; DNM2; DTNBP1; FTH1; FTL; GAK; GBF1; GNS; GOLGB1; HGS; HIP1R; HSPA8; IGF2R; M6PR; NAPA; PICALM; PIK3C2A; PUM1; RAB5C; SH3D19; SH3GL2; SNAP23; SNAPIN; SNX2; SNX5; SNX9; SORT1; STX4; TFRC; TGOLN2; TPD52; TPD52L1; TXNDC5"
"R-HSA-156902","Peptide chain elongation",0.0475732940031882,0.188682306189347,0.80093720615211,54,"EEF2; FAU; RPL10A; RPL12; RPL13; RPL13A; RPL14; RPL15; RPL17; RPL18; RPL18A; RPL19; RPL21; RPL22L1; RPL23A; RPL26; RPL26L1; RPL27A; RPL28; RPL29; RPL3; RPL30; RPL31; RPL32; RPL34; RPL35; RPL35A; RPL36; RPL36AL; RPL37; RPL38; RPL39L; RPL3L; RPL4; RPL41; RPL5; RPL7; RPL7A; RPL8; RPL9; RPLP0; RPLP2; RPS10; RPS11; RPS12; RPS13; RPS14; RPS15; RPS15A; RPS16; RPS18; RPS19; RPS2; RPS20"
"R-HSA-446193","Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein",0.0452372574182131,0.180603690774249,0.802217689638916,59,"ALG1; ALG10; ALG11; ALG12; ALG14; ALG3; ALG5; ALG6; ALG8; ALG9; AMDHD2; CMAS; CTSA; DHDDS; DOLK; DOLPP1; DPAGT1; DPM1; DPM2; FPGT; FUOM; GFPT1; GFPT2; GLB1; GMDS; GMPPB; GNE; GNPNAT1; MPDU1; MPI; MVD; NAGK; NANP; NANS; NEU1; NEU3; NEU4; NPL; NUDT14; NUS1; PGM3; PMM1; PMM2; RFT1; SLC17A5; SLC35A1; SLC35C1; SRD5A3; ST3GAL1; ST3GAL3; ST3GAL4; ST3GAL5; ST3GAL6; ST6GAL1; ST6GAL2; ST6GALNAC1; ST6GALNAC2; ST6GALNAC3; ST6GALNAC4"
"R-HSA-2197563","NOTCH2 intracellular domain regulates transcription",0.107690768085514,0.434991363957934,0.804467202831197,10,"EP300; FCER2; GZMB; HES1; HES5; MAML1; MAML2; MAML3; NOTCH2; RBPJ"
"R-HSA-418359","Reduction of cytosolic Ca++ levels",0.106729583294826,0.435034903557536,0.806196528154445,10,"ATP2A1; ATP2A2; ATP2A3; ATP2B1; ATP2B2; ATP2B4; CALM1; SLC8A1; SLC8A3; SRI"
"R-HSA-2032785","YAP1- and WWTR1 (TAZ)-stimulated gene expression",0.0680893672729899,0.282060133579771,0.809244972552585,24,"CARM1; CHD9; CTGF; HIPK1; HIPK2; KAT2B; NCOA1; NCOA2; NCOA6; NKX2-5; NPPA; PPARA; RUNX2; RXRA; SMARCD3; TBL1XR1; TBX5; TEAD1; TEAD2; TEAD3; TEAD4; TGS1; WWTR1; YAP1"
"R-HSA-1500931","Cell-Cell communication",0.0430640822969817,0.179126770659291,0.810011494661189,60,"ACTN1; ACTN2; ACTN4; AFDN; ANG; CADM1; CADM2; CADM3; CD151; CD2AP; CD47; CDH1; CDH10; CDH11; CDH12; CDH13; CDH15; CDH17; CDH18; CDH2; CDH24; CDH3; CDH4; CDH5; CDH6; CDH7; CDH8; CLDN1; CLDN10; CLDN11; CLDN12; CLDN14; CLDN15; CLDN16; CLDN18; CLDN19; CLDN20; CLDN23; CLDN3; CLDN4; CLDN5; CLDN6; CLDN7; CLDN8; CLDN9; COL17A1; CRB3; CTNNA1; CTNNB1; CTNND1; DST; F11R; FBLIM1; FERMT2; FLNC; FYB; FYN; GRB2; ILK; IQGAP1"
"R-HSA-5260271","Diseases of Immune System",0.0706847832248472,0.29449746592982,0.810316064344544,22,"CD14; CD36; CHUK; IKBKB; IRAK4; LY96; MYD88; NFKB1; NFKB2; NFKBIA; NFKBIB; RELA; TICAM1; TIRAP; TLR1; TLR10; TLR2; TLR3; TLR4; TLR5; TLR6; TRAF3"
"R-HSA-5602358","Diseases associated with the TLR signaling cascade",0.0706847832248472,0.29449746592982,0.810316064344544,22,"CD14; CD36; CHUK; IKBKB; IRAK4; LY96; MYD88; NFKB1; NFKB2; NFKBIA; NFKBIB; RELA; TICAM1; TIRAP; TLR1; TLR10; TLR2; TLR3; TLR4; TLR5; TLR6; TRAF3"
"R-HSA-6791312","TP53 Regulates Transcription of Cell Cycle Genes",0.0512199894999506,0.213734942690722,0.810607365412294,42,"ARID3A; AURKA; BAX; CARM1; CCNA1; CCNA2; CCNB1; CCNE1; CCNE2; CDK1; CDK2; CDKN1B; CENPJ; CNOT1; CNOT11; CNOT2; CNOT3; CNOT4; CNOT6; CNOT6L; CNOT7; CNOT8; E2F1; E2F4; E2F7; E2F8; EP300; GADD45A; NPM1; PCBP4; PCNA; PLAGL1; PLK2; PLK3; PRMT1; RBL1; RBL2; RGCC; SFN; TFDP1; TNKS1BP1; ZNF385A"
"R-HSA-391160","Signal regulatory protein family interactions",-0.0978736232661871,0.416947630722073,0.814411774839298,11,"CD47; FYB; GRB2; PTK2; PTK2B; PTPN6; SIRPA; SIRPB1; SIRPG; SKAP2; SRC"
"R-HSA-110312","Translesion synthesis by REV1",-0.0866468359165377,0.36987832980175,0.814784945690214,14,"MAD2L2; PCNA; REV1; REV3L; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3; UBA52; UBC"
"R-HSA-8866654","E3 ubiquitin ligases ubiquitinate target proteins",0.0500219861186417,0.216325899174774,0.817132718882435,41,"BCL10; CDC73; CTR9; DERL1; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HLA-A; HLA-B; HLTF; LEO1; PAF1; PCNA; PEX10; PEX12; PEX2; PEX5; PRKDC; RAD18; RNF144A; RNF152; RNF181; RNF20; RNF40; RRAGA; RTF1; SELENOS; SHPRH; TMEM129; UBA52; UBC; UBE2D1; UBE2D3; UBE2E1; UBE2J2; UBE2L3; UBE2N; VCP; WAC; WDR61"
"R-HSA-1650814","Collagen biosynthesis and modifying enzymes",0.040603964538895,0.177688496108907,0.819248180487298,61,"ADAMTS14; ADAMTS2; ADAMTS3; BMP1; COL10A1; COL11A1; COL11A2; COL12A1; COL13A1; COL14A1; COL15A1; COL16A1; COL17A1; COL18A1; COL19A1; COL1A1; COL1A2; COL20A1; COL21A1; COL22A1; COL23A1; COL24A1; COL25A1; COL27A1; COL28A1; COL2A1; COL3A1; COL4A1; COL4A2; COL4A3; COL4A4; COL5A1; COL5A2; COL5A3; COL6A1; COL6A2; COL6A3; COL6A5; COL6A6; COL8A1; COL8A2; COL9A1; COL9A2; COL9A3; COLGALT1; COLGALT2; CRTAP; P3H1; P3H2; P4HA1; P4HA2; P4HA3; P4HB; PCOLCE; PCOLCE2; PLOD1; PLOD2; PLOD3; SERPINH1; TLL1; TLL2"
"R-HSA-422356","Regulation of insulin secretion",0.040449969837679,0.18064951212007,0.822824157346815,59,"ABCC8; ADCY5; ADCY6; ADRA2A; ADRA2C; AHCYL1; ARL2; ARL2BP; CACNA1A; CACNA1C; CACNA1D; CACNA1E; CACNA2D2; CACNB2; CACNB3; CHRM3; FFAR1; GCG; GLP1R; GNA11; GNA14; GNA15; GNAI1; GNAI2; GNAQ; GNAS; GNB1; GNB2; GNB3; GNB4; GNB5; GNG10; GNG11; GNG12; GNG2; GNG3; GNG4; GNG5; GNG7; GNGT2; IQGAP1; ITPR1; ITPR2; ITPR3; KCNB1; KCNC2; KCNG2; KCNJ11; KCNS3; PLCB1; PLCB2; PLCB3; PRKACB; PRKAR1A; PRKAR1B; PRKAR2A; PRKAR2B; PRKCA; RAP1A"
"R-HSA-622323","Presynaptic nicotinic acetylcholine receptors",0.0876471443169395,0.3979234948471,0.825667661983839,12,"CHRNA1; CHRNA2; CHRNA3; CHRNA4; CHRNA5; CHRNA6; CHRNB2; CHRNB3; CHRNB4; CHRND; CHRNE; CHRNG"
"R-HSA-70614","Amino acid synthesis and interconversion (transamination)",0.0595838423352383,0.271197834587437,0.826099985365415,26,"ALDH18A1; ASNS; ASPA; ASPG; FOLH1; GADL1; GLS; GLUD1; GLUL; GOT1; GOT2; GPT; KYAT1; NAALAD2; NAT8L; OAT; PHGDH; PSAT1; PSPH; PYCR1; PYCR2; RIMKLA; SERINC1; SERINC2; SERINC3; SERINC5"
"R-HSA-912526","Interleukin receptor SHC signaling",-0.0675871604157053,0.309797016440773,0.827299813994603,20,"CSF2RB; GAB2; GRB2; IL2RA; IL2RB; IL5; INPP5D; INPPL1; JAK1; JAK2; JAK3; PIK3CA; PIK3CB; PIK3CD; PIK3R1; PIK3R2; PIK3R3; PTPN6; SHC1; SOS1"
"R-HSA-1266738","Developmental Biology",0.0373905763906737,0.17354010718405,0.82941038007886,64,"ABL1; ABL2; ABLIM1; ABLIM2; ABLIM3; ACTG1; ACTR2; ACTR3; ACVR1B; ACVR1C; ACVR2A; ACVR2B; ADAM10; ADAM11; ADAM22; ADAM23; ADIPOQ; ADIRF; AGAP2; AGRN; AJUBA; AKT1; AKT2; AKT3; ALCAM; ANGPTL4; ANK1; ANK2; ANK3; AP2A1; AP2A2; AP2B1; AP2M1; AP2S1; APH1A; APH1B; ARHGAP35; ARHGAP39; ARHGEF11; ARHGEF12; ARHGEF28; ARHGEF7; ARPC1A; ARPC1B; ARPC2; ARPC3; ARPC4; ARPC5; ARTN; BNIP2; BOC; CACNA1C; CACNA1D; CACNA1G; CACNA1H; CACNA1I; CACNA1S; CACNB1; CACNB2; CACNB3; CACNB4; CACNG3; CACNG4; CACNG8"
"R-HSA-168271","Transport of Ribonucleoproteins into the Host Nucleus",-0.0565525894434377,0.266858575617644,0.832169680802369,27,"KPNA1; KPNB1; NDC1; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188; NUP205; NUP210; NUP214; NUP35; NUP43; NUP50; NUP54; NUP58; NUP62; NUP85; NUP88; NUP93; NUP98; NUPL2; POM121; RAE1; RANBP2; SEH1L"
"R-HSA-77387","Insulin receptor recycling",-0.0610044432830571,0.289016176099802,0.83282779233751,23,"ATP6V0A1; ATP6V0A2; ATP6V0A4; ATP6V0B; ATP6V0C; ATP6V0D1; ATP6V0D2; ATP6V0E1; ATP6V0E2; ATP6V1A; ATP6V1B1; ATP6V1B2; ATP6V1C1; ATP6V1C2; ATP6V1D; ATP6V1E1; ATP6V1E2; ATP6V1F; ATP6V1G1; ATP6V1G2; ATP6V1H; INSR; TCIRG1"
"R-HSA-1474290","Collagen formation",0.0368472816071806,0.174903839482681,0.833143492987733,63,"ADAMTS14; ADAMTS2; ADAMTS3; BMP1; CD151; COL10A1; COL11A1; COL11A2; COL12A1; COL13A1; COL14A1; COL15A1; COL16A1; COL17A1; COL18A1; COL19A1; COL1A1; COL1A2; COL20A1; COL21A1; COL22A1; COL23A1; COL24A1; COL25A1; COL27A1; COL28A1; COL2A1; COL3A1; COL4A1; COL4A2; COL4A3; COL4A4; COL5A1; COL5A2; COL5A3; COL6A1; COL6A2; COL6A3; COL6A5; COL6A6; COL8A1; COL8A2; COL9A1; COL9A2; COL9A3; COLGALT1; COLGALT2; CRTAP; CTSB; CTSL; CTSS; CTSV; DST; ITGA6; ITGB4; LAMA3; LAMB3; LAMC2; LOX; LOXL1; LOXL2; LOXL3; LOXL4"
"R-HSA-2564830","Cytosolic iron-sulfur cluster assembly",-0.0852623433157733,0.417214259538131,0.838071367011924,11,"BRIP1; CIAO1; CIAPIN1; FAM96B; MMS19; NARFL; NDOR1; NUBP1; NUBP2; POLD1; RTEL1"
"R-HSA-2142753","Arachidonic acid metabolism",-0.0385815065162388,0.189089481264474,0.838323527150232,54,"ABCC1; AKR1C3; ALOX12; ALOX12B; ALOX15; ALOX15B; ALOX5; ALOX5AP; ALOXE3; CBR1; CYP1A1; CYP1A2; CYP1B1; CYP2C19; CYP2C8; CYP2C9; CYP2J2; CYP2U1; CYP4A11; CYP4A22; CYP4B1; CYP4F11; CYP4F2; CYP4F22; CYP4F3; CYP8B1; DPEP1; DPEP2; DPEP3; EPHX2; FAAH; FAM213B; GGT1; GGT5; GPX1; GPX2; GPX4; HPGD; HPGDS; LTA4H; MAPKAPK2; PLA2G4A; PON1; PON2; PON3; PTGDS; PTGES; PTGES2; PTGIS; PTGR1; PTGR2; PTGS1; PTGS2; TBXAS1"
"R-HSA-112409","RAF-independent MAPK1/3 activation",0.0645844276787529,0.316947750021413,0.838533275311575,19,"CDK1; DUSP1; DUSP10; DUSP16; DUSP2; DUSP4; DUSP5; DUSP7; DUSP8; IL6R; IL6ST; JAK1; JAK2; MAP2K1; MAP2K2; MAPK1; MAPK3; PEA15; TYK2"
"R-HSA-1268020","Mitochondrial protein import",0.0391728060853919,0.192332017031458,0.838609176150649,52,"ACO2; ATP5A1; ATP5B; ATP5G1; BCS1L; CHCHD10; CHCHD2; CHCHD3; CHCHD4; CHCHD5; CMC2; COA4; COA6; COQ2; COX17; COX19; CS; CYC1; DNAJC19; FXN; GFER; GRPEL1; GRPEL2; HSCB; HSPD1; LDHD; MTX1; MTX2; NDUFB8; PAM16; PITRM1; PMPCA; PMPCB; SAMM50; SLC25A12; SLC25A13; SLC25A4; TIMM10; TIMM10B; TIMM13; TIMM17A; TIMM21; TIMM22; TIMM44; TIMM50; TIMM9; TOMM20; TOMM22; TOMM5; TOMM7; TOMM70; VDAC1"
"R-HSA-163685","Integration of energy metabolism",0.0363189645866679,0.179188003324157,0.839380183130856,60,"ABCC8; ACACB; ACLY; ADCY1; ADCY2; ADCY3; ADCY4; ADCY5; ADCY6; ADCY7; ADCY9; ADIPOQ; ADIPOR1; ADIPOR2; ADRA2A; ADRA2C; AGPAT1; AHCYL1; ARL2; ARL2BP; CACNA1A; CACNA1C; CACNA1D; CACNA1E; CACNA2D2; CACNB2; CACNB3; CHRM3; FASN; FFAR1; GCG; GLP1R; GNA11; GNA14; GNA15; GNAI1; GNAI2; GNAQ; GNAS; GNB1; GNB2; GNB3; GNB4; GNB5; GNG10; GNG11; GNG12; GNG2; GNG3; GNG4; GNG5; GNG7; GNGT2; IQGAP1; ITPR1; ITPR2; ITPR3; KCNB1; KCNC2; KCNG2"
"R-HSA-5684264","MAP3K8 (TPL2)-dependent MAPK1/3 activation",0.0770876591486268,0.382684123378389,0.840355011979499,13,"BTRC; CHUK; CUL1; FBXW11; IKBKB; MAP2K1; MAP2K4; MAP3K8; NFKB1; SKP1; TNIP2; UBA52; UBC"
"R-HSA-6804760","Regulation of TP53 Activity through Methylation",0.0694050023622294,0.345228093558158,0.840666512397468,16,"ATM; CHEK2; EHMT1; EHMT2; EP300; JMY; KMT5A; L3MBTL1; MDM2; MDM4; PRMT5; SETD9; SMYD2; TTC5; UBA52; UBC"
"R-HSA-392154","Nitric oxide stimulates guanylate cyclase",0.0565970294835253,0.282284380273452,0.84109229714331,24,"GUCY1A2; GUCY1A3; GUCY1B3; ITPR1; KCNMA1; KCNMB1; KCNMB2; KCNMB3; KCNMB4; MRVI1; NOS1; NOS2; NOS3; PDE10A; PDE11A; PDE1A; PDE1B; PDE2A; PDE3A; PDE3B; PDE5A; PDE9A; PRKG1; PRKG2"
"R-HSA-74217","Purine salvage",-0.079940846392609,0.39957383263073,0.841429535363355,12,"ADA; ADAL; ADK; AMPD1; AMPD2; AMPD3; APRT; DCK; DGUOK; GMPR; GMPR2; PNP"
"R-HSA-1296065","Inwardly rectifying K+ channels",-0.0524245872615003,0.262090571041433,0.841461265402766,28,"ABCC8; ABCC9; GABBR1; GABBR2; GNB1; GNB2; GNB3; GNG10; GNG12; GNG2; GNG3; GNG4; GNG5; GNG7; GNGT2; KCNJ1; KCNJ10; KCNJ11; KCNJ12; KCNJ14; KCNJ15; KCNJ16; KCNJ2; KCNJ3; KCNJ4; KCNJ5; KCNJ6; KCNJ8"
"R-HSA-75153","Apoptotic execution  phase",0.0419860633757628,0.21136011514235,0.842538846340338,43,"ADD1; APC; BIRC2; CASP3; CASP6; CASP7; CASP8; CDH1; CTNNB1; DBNL; DFFA; DFFB; DNM1L; DSG1; DSG2; DSG3; DSP; FNTA; GAS2; GSN; H1F0; HIST1H1C; HIST1H1D; HIST1H1E; HMGB2; KPNA1; KPNB1; LMNA; LMNB1; MAPT; OCLN; PAK2; PKP1; PLEC; PRKCD; PRKCQ; PTK2; ROCK1; SATB1; STK24; TJP1; TJP2; VIM"
"R-HSA-450513","Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA",0.0707411053695404,0.356488539395692,0.842701878411424,15,"DCP2; DIS3; EXOSC1; EXOSC2; EXOSC3; EXOSC4; EXOSC5; EXOSC6; EXOSC7; EXOSC8; EXOSC9; MAPKAPK2; TNPO1; XRN1; YWHAB"
"R-HSA-3000171","Non-integrin membrane-ECM interactions",0.0439941641440036,0.221848176331396,0.842804459676918,39,"ACTN1; AGRN; DAG1; DDR1; DDR2; FGF2; HSPG2; ITGA2; ITGA6; ITGAV; ITGB1; ITGB3; ITGB4; ITGB5; LAMA1; LAMA2; LAMA3; LAMA4; LAMA5; LAMB1; LAMB2; LAMB3; LAMC1; LAMC2; LAMC3; NRXN1; NTN4; PDGFB; PRKCA; SDC1; SDC2; SDC3; SDC4; TGFB1; THBS1; TNC; TRAPPC4; TTR; VTN"
"R-HSA-420029","Tight junction interactions",-0.0528028926284453,0.266878802122037,0.843159723003933,27,"CLDN1; CLDN10; CLDN11; CLDN12; CLDN14; CLDN15; CLDN16; CLDN18; CLDN19; CLDN20; CLDN23; CLDN3; CLDN4; CLDN5; CLDN6; CLDN7; CLDN8; CLDN9; CRB3; F11R; MPP5; PARD3; PARD6A; PARD6B; PARD6G; PATJ; PRKCI"
"R-HSA-211935","Fatty acids",-0.0759633336497541,0.383986158970897,0.843179394163125,13,"CYP2A13; CYP2A7; CYP2D6; CYP2F1; CYP2J2; CYP4A11; CYP4A22; CYP4B1; CYP4F11; CYP4F12; CYP4F2; CYP4F22; CYP4F3"
"R-HSA-389957","Prefoldin mediated transfer of substrate  to CCT/TriC",0.0573671832159907,0.294774203972747,0.845695152074696,22,"CCT2; CCT3; CCT4; CCT5; CCT6A; CCT6B; CCT7; CCT8; PFDN1; PFDN5; PFDN6; TCP1; TUBA1A; TUBA1C; TUBA3C; TUBA4A; TUBB1; TUBB2A; TUBB2B; TUBB3; TUBB4A; TUBB6"
"R-HSA-1980143","Signaling by NOTCH1",0.0349509792408655,0.182235815297958,0.847906823790584,58,"ADAM10; ADAM17; APH1A; APH1B; ARRB1; ARRB2; CCNC; CDK8; CNTN1; CUL1; DLK1; DLL1; DNER; DTX1; DTX2; DTX4; EP300; FBXW7; HDAC1; HDAC10; HDAC11; HDAC2; HDAC3; HDAC4; HDAC5; HDAC7; HDAC9; HES1; HES5; HEY1; HEY2; HEYL; HIF1A; ITCH; JAG1; JAG2; KAT2A; KAT2B; MAML1; MAML2; MAML3; MIB1; MIB2; MYC; NCOR1; NCSTN; NEURL1; NEURL1B; NOTCH1; NUMB; PSEN1; PSEN2; RBPJ; SKP1; SNW1; TBL1XR1; TLE1; TLE2"
"R-HSA-2173796","SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription",-0.0511444877472803,0.266886812234222,0.848029200355438,27,"CCNC; CCNK; CCNT1; CCNT2; CDK8; CDK9; CDKN2B; E2F4; E2F5; HDAC1; JUNB; MEN1; MYC; RBL1; RNF111; SERPINE1; SMAD2; SMAD3; SMAD4; SNW1; SP1; TFDP1; TGIF1; TGIF2; UBA52; UBC; WWTR1"
"R-HSA-5693579","Homologous DNA Pairing and Strand Exchange",0.0401420938469795,0.213867152666418,0.851114655383318,42,"ATM; ATR; ATRIP; BARD1; BLM; BRCA1; BRCA2; BRIP1; CHEK1; DNA2; EXO1; HUS1; KAT5; MRE11; NBN; PALB2; RAD1; RAD17; RAD50; RAD51; RAD51AP1; RAD51B; RAD51C; RAD51D; RAD9A; RAD9B; RBBP8; RFC2; RFC3; RFC4; RFC5; RHNO1; RMI1; RMI2; RPA1; RPA2; RPA3; TOP3A; TOPBP1; WRN; XRCC2; XRCC3"
"R-HSA-442660","Na+/Cl- dependent neurotransmitter transporters",-0.0670262141650673,0.357631819382031,0.851333844909536,15,"SLC18A1; SLC18A2; SLC22A1; SLC22A2; SLC6A1; SLC6A11; SLC6A12; SLC6A13; SLC6A15; SLC6A19; SLC6A2; SLC6A3; SLC6A6; SLC6A7; SLC6A9"
"R-HSA-1980145","Signaling by NOTCH2",-0.0493651721520515,0.266894769054153,0.853259481879018,27,"ADAM10; APH1A; APH1B; CNTN1; DLL1; EP300; FCER2; GZMB; HES1; HES5; JAG1; JAG2; MAML1; MAML2; MAML3; MDK; MIB1; MIB2; NCSTN; NEURL1; NEURL1B; NOTCH2; PSEN1; PSEN2; RBPJ; UBA52; UBC"
"R-HSA-76002","Platelet activation, signaling and aggregation",0.0330366944085919,0.179215672947944,0.853746397947662,60,"A1BG; A2M; ABCC4; ABHD12; ABHD6; ACTN1; ACTN2; ACTN4; ADRA2A; ADRA2C; AKT1; AKT2; AKT3; ALB; ANXA5; APBB1IP; APLP2; APOA1; APOH; APP; ARRB1; ARRB2; BCAR1; BRPF3; CALM1; CALU; CAP1; CD109; CD36; CD63; CD9; CDC37L1; CDC42; CFD; CFL1; CHID1; CLEC1B; CLEC3B; CLU; CRK; CSF2RB; CSK; CTSW; CYB5R1; DAGLA; DAGLB; DGKA; DGKB; DGKD; DGKE; DGKG; DGKH; DGKI; DGKQ; ECM1; EGF; ENDOD1; F13A1; F2; F2R"
"R-HSA-170822","Regulation of Glucokinase by Glucokinase Regulatory Protein",-0.0489474952352111,0.266896541297816,0.854488086871016,27,"GCK; GCKR; NDC1; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188; NUP205; NUP210; NUP214; NUP35; NUP43; NUP50; NUP54; NUP58; NUP62; NUP85; NUP88; NUP93; NUP98; NUPL2; POM121; RAE1; RANBP2; SEH1L"
"R-HSA-442742","CREB phosphorylation through the activation of Ras",0.0524213308323622,0.288409222348802,0.855770884874638,23,"ACTN2; AKAP9; BRAF; CALM1; CAMK2A; CAMK2B; CAMK2D; CAMK2G; DLG4; GRIN1; GRIN2A; GRIN2B; GRIN2C; GRIN2D; HRAS; MAPK1; PDPK1; RAF1; RASGRF1; RASGRF2; RPS6KA1; RPS6KA2; RRAS"
"R-HSA-5696399","Global Genome Nucleotide Excision Repair (GG-NER)",-0.0330392773804944,0.184093941946292,0.857568937444167,57,"ACTL6A; ACTR5; ACTR8; CCNH; CDK7; CHD1L; COPS2; COPS3; COPS6; COPS7A; COPS7B; COPS8; CUL4A; DDB1; DDB2; ERCC3; ERCC4; ERCC5; GPS1; GTF2H1; GTF2H2; GTF2H3; GTF2H4; GTF2H5; INO80; INO80B; INO80C; INO80D; INO80E; LIG1; LIG3; MCRS1; MNAT1; NFRKB; PARP1; PARP2; PCNA; PIAS1; PIAS3; POLD1; POLD2; POLD3; POLE; POLE2; POLE3; POLE4; POLK; RAD23B; RFC1; RFC2; RFC3; RFC4; RFC5; RNF111; RPA1; RPA2; RPA3"
"R-HSA-176033","Interactions of Vpr with host cellular proteins",-0.0447282789015031,0.2532696252546,0.859819917158583,30,"BANF1; HMGA1; KPNA1; NDC1; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188; NUP205; NUP210; NUP214; NUP35; NUP43; NUP50; NUP54; NUP58; NUP62; NUP85; NUP88; NUP93; NUP98; NUPL2; POM121; PSIP1; RAE1; RANBP2; SEH1L; SLC25A4"
"R-HSA-6781827","Transcription-Coupled Nucleotide Excision Repair (TC-NER)",0.0318457203170243,0.180724355767976,0.860127740814675,59,"AQR; CCNH; CDK7; COPS2; COPS3; COPS6; COPS7A; COPS7B; COPS8; CUL4A; DDB1; ELL; EP300; ERCC3; ERCC4; ERCC5; ERCC6; ERCC8; GPS1; GTF2H1; GTF2H2; GTF2H3; GTF2H4; GTF2H5; HMGN1; ISY1; LIG1; LIG3; MNAT1; PCNA; POLD1; POLD2; POLD3; POLE; POLE2; POLE3; POLE4; POLK; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; PPIE; PRPF19; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3"
"R-HSA-438066","Unblocking of NMDA receptor, glutamate binding and activation",0.0621513291502083,0.356711564725335,0.861681463860819,15,"ACTN2; AKAP9; CAMK2A; CAMK2B; CAMK2D; CAMK2G; DLG4; GRIA1; GRIA2; GRIA4; GRIN1; GRIN2A; GRIN2B; GRIN2C; GRIN2D"
"R-HSA-1834941","STING mediated induction of host immune responses",0.0618496117758528,0.356719038407875,0.862349076341952,15,"DDX41; DTX4; IFI16; IRF3; MB21D1; MRE11; NLRP4; PRKDC; STAT6; TBK1; TMEM173; TREX1; TRIM21; XRCC5; XRCC6"
"R-HSA-1222556","ROS, RNS production in phagocytes",-0.0438714294448022,0.253272232457126,0.862479703505299,30,"ATP6V0A1; ATP6V0A2; ATP6V0A4; ATP6V0B; ATP6V0C; ATP6V0D1; ATP6V0D2; ATP6V0E1; ATP6V0E2; ATP6V1A; ATP6V1B1; ATP6V1B2; ATP6V1C1; ATP6V1C2; ATP6V1D; ATP6V1E1; ATP6V1E2; ATP6V1F; ATP6V1G1; ATP6V1G2; ATP6V1H; CYBA; NCF1; NCF2; NCF4; NOS1; NOS2; NOS3; SLC11A1; TCIRG1"
"R-HSA-69620","Cell Cycle Checkpoints",-0.0312248730744756,0.182514508011123,0.864159607859163,58,"AHCTF1; ANAPC1; ANAPC10; ANAPC11; ANAPC15; ANAPC16; ANAPC2; ANAPC4; ANAPC5; ANAPC7; ATM; ATR; ATRIP; AURKB; B9D2; BABAM1; BARD1; BIRC5; BLM; BRCA1; BRIP1; BUB1B; BUB3; CCNA1; CCNA2; CCNB1; CCNB2; CCNE1; CCNE2; CDC16; CDC25A; CDC26; CDC27; CDC45; CDC6; CDC7; CDK1; CDK2; CDKN1B; CDKN2A; CENPA; CENPC; CENPE; CENPF; CENPH; CENPK; CENPL; CENPM; CENPN; CENPO; CENPP; CENPQ; CENPT; CENPU; CHEK1; CHEK2; CKAP5; CLASP1"
"R-HSA-180910","Vpr-mediated nuclear import of PICs",-0.0438133570638055,0.257583892320734,0.864936570854088,29,"BANF1; HMGA1; KPNA1; NDC1; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188; NUP205; NUP210; NUP214; NUP35; NUP43; NUP50; NUP54; NUP58; NUP62; NUP85; NUP88; NUP93; NUP98; NUPL2; POM121; PSIP1; RAE1; RANBP2; SEH1L"
"R-HSA-3296482","Defects in vitamin and cofactor metabolism",-0.0588533383722071,0.346377103175785,0.86507999757909,16,"AMN; CD320; CUBN; GIF; MCCC1; MCCC2; MMAA; MMACHC; MMADHC; MTR; MTRR; MUT; PC; PCCA; PCCB; TCN2"
"R-HSA-418346","Platelet homeostasis",0.0301079981082665,0.177777102334807,0.865514952922751,61,"APOB; ATP2A1; ATP2A2; ATP2A3; ATP2B1; ATP2B2; ATP2B4; CALM1; FGR; GNAS; GNB1; GNB2; GNB3; GNB4; GNB5; GNG10; GNG11; GNG12; GNG2; GNG3; GNG4; GNG5; GNG7; GNGT2; GUCY1A2; GUCY1A3; GUCY1B3; ITPR1; ITPR2; ITPR3; KCNMA1; KCNMB1; KCNMB2; KCNMB3; KCNMB4; LRP8; MAPK14; MRVI1; NOS1; NOS2; NOS3; ORAI2; P2RX1; P2RX2; P2RX3; P2RX4; P2RX5; P2RX6; P2RX7; PAFAH2; PDE10A; PDE11A; PDE1A; PDE1B; PDE2A; PDE3A; PDE3B; PDE5A; PDE9A; PLA2G4A; PPP2CA"
"R-HSA-9012852","Signaling by NOTCH3",-0.0369037836630656,0.219507188158784,0.866488032671189,40,"ADAM10; APH1A; APH1B; DLL1; EGF; EGFR; EP300; FABP7; HES1; HES5; HEY1; HEY2; HEYL; IKZF1; JAG1; JAG2; KAT2A; KAT2B; MAML1; MAML2; MAML3; MIB1; MIB2; NCSTN; NEURL1; NEURL1B; NOTCH1; NOTCH3; PBX1; PLXND1; PSEN1; PSEN2; RBPJ; SNW1; STAT1; TACC3; UBA52; UBC; WWC1; WWP2"
"R-HSA-156842","Eukaryotic Translation Elongation",-0.0316390638615796,0.189095170087825,0.867119682914353,54,"EEF1A2; EEF1B2; EEF1D; EEF1G; EEF2; FAU; RPL10A; RPL12; RPL13; RPL13A; RPL14; RPL15; RPL17; RPL18; RPL18A; RPL19; RPL21; RPL22L1; RPL23A; RPL26; RPL26L1; RPL27A; RPL28; RPL29; RPL3; RPL30; RPL31; RPL32; RPL34; RPL35; RPL35A; RPL36; RPL36AL; RPL37; RPL38; RPL39L; RPL3L; RPL4; RPL41; RPL5; RPL7; RPL7A; RPL8; RPL9; RPLP0; RPLP2; RPS10; RPS11; RPS12; RPS13; RPS14; RPS15; RPS15A; RPS16"
"R-HSA-5674135","MAP2K and MAPK activation",0.0391000866356478,0.234177217116488,0.867395277972141,35,"APBB1IP; ARRB1; ARRB2; BRAF; CNKSR1; CSK; FGA; FGB; FGG; FN1; HRAS; IL17RD; IQGAP1; ITGA2B; ITGB3; KRAS; KSR1; KSR2; LAMTOR2; LAMTOR3; MAP2K1; MAP2K2; MAPK1; MAPK3; MARK3; NRAS; PEBP1; RAF1; RAP1A; RAP1B; SRC; TLN1; VCL; VWF; YWHAB"
"R-HSA-140875","Common Pathway of Fibrin Clot Formation",-0.0527507020273232,0.31792988832218,0.868220464978604,19,"F10; F13A1; F2; F2R; F5; FGA; FGB; FGG; PF4; PF4V1; PROC; PROCR; PROS1; PRTN3; SERPINA5; SERPINC1; SERPIND1; SERPINE2; THBD"
"R-HSA-399956","CRMPs in Sema3A signaling",-0.0632487454593643,0.384146061530362,0.869221325418976,13,"CDK5R1; CRMP1; DPYSL2; DPYSL4; DPYSL5; FES; FYN; GSK3B; NRP1; PLXNA1; PLXNA2; PLXNA4; SEMA3A"
"R-HSA-2162123","Synthesis of Prostaglandins (PG) and Thromboxanes (TX)",0.0603797174821726,0.369250357659016,0.870109242708122,14,"AKR1C3; CBR1; CYP8B1; FAM213B; HPGD; HPGDS; PTGDS; PTGES; PTGES2; PTGIS; PTGR2; PTGS1; PTGS2; TBXAS1"
"R-HSA-400253","Circadian Clock",-0.0300620225534303,0.184094818633499,0.87028506220481,57,"ARNTL; ARNTL2; ATF2; BHLHE40; BHLHE41; BTRC; CARM1; CHD9; CLOCK; CPT1A; CREM; CRTC1; CRTC2; CRTC3; CRY1; CRY2; CSNK1D; CSNK1E; CUL1; DBP; ELOVL3; EP300; F7; FBXL3; HDAC3; HIF1A; KLF15; MEF2C; MEF2D; NAMPT; NCOA1; NCOA2; NCOA6; NCOR1; NFIL3; NOCT; NPAS2; NR1D1; NR3C1; NRIP1; PER2; PPARA; PPARGC1A; PPP1CB; RAI1; RBM4; RORA; RXRA; SERPINE1; SIK1; SIRT1; SKP1; SMARCD3; SREBF1; TBL1XR1; TGS1; UBA52"
"R-HSA-168256","Immune System",0.0287226833078281,0.177787741083104,0.8716554778859,61,"A1BG; ABCA13; ABCE1; ABI1; ABL1; ACAA1; ACLY; ACPP; ACTG1; ACTR10; ACTR1A; ACTR1B; ACTR2; ACTR3; ADAM10; ADAM17; ADAM8; ADAR; ADGRG3; AGA; AGER; AGL; AGPAT2; AHCYL1; AIM2; AIP; AKT1; AKT2; AKT3; ALAD; ALDH3B1; ALDOC; ALOX15; ALOX5; AMPD3; ANAPC1; ANAPC10; ANAPC11; ANAPC13; ANAPC2; ANAPC4; ANAPC5; ANAPC7; ANO6; ANPEP; ANXA1; ANXA2; AOC1; AP1B1; AP1G1; AP1M1; AP1M2; AP1S1; AP1S3; AP2A1; AP2A2; AP2B1; AP2M1; AP2S1; APAF1; APEH"
"R-HSA-109606","Intrinsic Pathway for Apoptosis",-0.0353729307715901,0.219509017524544,0.871978659773355,40,"AKT1; AKT2; AKT3; APAF1; BAD; BAK1; BAX; BBC3; BCL2; BCL2L1; BCL2L11; BID; BMF; CASP3; CASP7; CASP8; CASP9; CYCS; DIABLO; DYNLL1; DYNLL2; E2F1; GZMB; MAPK8; NMT1; PMAIP1; PPP1R13B; PPP3CC; PPP3R1; SFN; TFDP1; TP53BP2; TP63; TP73; YWHAB; YWHAE; YWHAG; YWHAH; YWHAQ; YWHAZ"
"R-HSA-418990","Adherens junctions interactions",0.0426054386977876,0.266421752285616,0.872946245870736,27,"AFDN; ANG; CADM1; CADM2; CADM3; CDH1; CDH10; CDH11; CDH12; CDH13; CDH15; CDH17; CDH18; CDH2; CDH24; CDH3; CDH4; CDH5; CDH6; CDH7; CDH8; CTNNA1; CTNNB1; CTNND1; JUP; NECTIN1; NECTIN3"
"R-HSA-445989","TAK1 activates NFkB by phosphorylation and activation of IKKs complex",-0.0451794120619871,0.283038740622416,0.873178284893204,24,"AGER; APP; CHUK; IKBKB; IRAK2; MAP3K7; MYD88; NFKB1; NFKB2; NFKBIA; NFKBIB; NKIRAS1; NOD1; NOD2; RELA; RIPK2; S100A12; S100B; SAA1; TAB1; TAB2; TRAF6; UBE2N; UBE2V1"
"R-HSA-6803211","TP53 Regulates Transcription of Death Receptors and Ligands",0.0660417584145312,0.416314094876167,0.873956883495186,11,"FAS; IGFBP3; PPP1R13B; TMEM219; TNFRSF10A; TNFRSF10B; TNFRSF10C; TNFRSF10D; TP53BP2; TP63; TP73"
"R-HSA-6803205","TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain",-0.066012975179921,0.41751741993131,0.874371449678609,11,"BCL2L14; BIRC5; NDRG1; PERP; PPP1R13B; RABGGTA; RABGGTB; TP53BP2; TP53I3; TP63; TP73"
"R-HSA-75876","Synthesis of very long-chain fatty acyl-CoAs",0.0454923702392003,0.288527429074876,0.87471615712772,23,"ACSBG1; ACSBG2; ACSF3; ACSL1; ACSL3; ACSL5; ACSL6; ELOVL1; ELOVL2; ELOVL3; ELOVL4; ELOVL5; ELOVL6; ELOVL7; HACD1; HACD2; HACD3; HACD4; HSD17B12; HSD17B3; SLC27A3; TECR; TECRL"
"R-HSA-5686938","Regulation of TLR by endogenous ligand",-0.056280085636518,0.35773279863201,0.874989218311803,15,"APOB; CD14; CD36; FGA; FGB; FGG; LBP; LY96; S100A1; S100A8; S100A9; TLR1; TLR2; TLR4; TLR6"
"R-HSA-5685942","HDR through Homologous Recombination (HRR)",-0.0274594572902083,0.176581014283626,0.876422200585109,62,"ATM; ATR; ATRIP; BARD1; BLM; BRCA1; BRCA2; BRIP1; CHEK1; DNA2; EME1; EME2; EXO1; GEN1; HUS1; KAT5; MRE11; MUS81; NBN; PALB2; PCNA; POLD1; POLD2; POLD3; POLE; POLE2; POLE3; POLE4; POLK; RAD1; RAD17; RAD50; RAD51; RAD51AP1; RAD51B; RAD51C; RAD51D; RAD9A; RAD9B; RBBP8; RFC1; RFC2; RFC3; RFC4; RFC5; RHNO1; RMI1; RMI2; RPA1; RPA2; RPA3; RTEL1; SLX1A; SLX4; SPIDR; TOP3A; TOPBP1; UBA52; UBC; WRN; XRCC2; XRCC3"
"R-HSA-6803207","TP53 Regulates Transcription of Caspase Activators and Caspases",-0.0677419726725717,0.43783966433044,0.877043106857601,10,"APAF1; ATM; CASP1; CASP10; CASP6; CRADD; NLRC4; PIDD1; TP63; TP73"
"R-HSA-419037","NCAM1 interactions",-0.0362138260197013,0.234582293446634,0.877313444457533,35,"AGRN; ARTN; CACNA1C; CACNA1D; CACNA1G; CACNA1H; CACNA1I; CACNA1S; CACNB1; CACNB2; CACNB3; CACNB4; CNTN2; COL4A1; COL4A2; COL4A3; COL4A4; COL6A1; COL6A2; COL6A3; COL6A5; COL6A6; COL9A1; COL9A2; COL9A3; GDNF; GFRA1; GFRA2; GFRA4; NCAM1; NRTN; PRNP; PSPN; ST8SIA2; ST8SIA4"
"R-HSA-432040","Vasopressin regulates renal water homeostasis via Aquaporins",-0.0361006188214175,0.237990580599065,0.879432015950103,34,"ADCY1; ADCY2; ADCY3; ADCY4; ADCY5; ADCY6; ADCY7; ADCY9; AQP1; AQP3; AQP4; GNAS; GNB1; GNB2; GNB3; GNB4; GNB5; GNG10; GNG11; GNG12; GNG2; GNG3; GNG4; GNG5; GNG7; GNGT2; MYO5B; PRKACB; PRKAR1A; PRKAR1B; PRKAR2A; PRKAR2B; RAB11A; RAB11FIP2"
"R-HSA-8951664","Neddylation",-0.0277488728977784,0.184094659747356,0.880187486464369,57,"ANKRD9; ASB1; ASB13; ASB14; ASB15; ASB16; ASB18; ASB2; ASB3; ASB4; ASB5; ASB6; ASB7; ASB8; BIRC5; BTBD1; BTBD6; BTRC; CAND1; CCDC8; CCNF; CISH; COMMD10; COMMD2; COMMD3; COMMD4; COMMD5; COMMD6; COMMD7; COMMD8; COMMD9; COPS2; COPS3; COPS6; COPS7A; COPS7B; COPS8; CUL1; CUL2; CUL3; CUL4A; CUL5; CUL7; CUL9; DCAF10; DCAF11; DCAF13; DCAF16; DCAF17; DCAF4; DCAF5; DCAF6; DCAF7; DCAF8; DCUN1D2; DCUN1D3; DCUN1D4"
"R-HSA-114604","GPVI-mediated activation cascade",0.0321529296884935,0.213950517597569,0.880542067241128,42,"AKT1; AKT2; AKT3; CDC42; CLEC1B; CSF2RB; FCER1G; FYN; GAB2; GP6; GRB2; IL2RA; IL2RB; IL5; JAK1; JAK2; JAK3; LAT; LCP2; LYN; PDPK1; PDPN; PIK3CA; PIK3CB; PIK3CD; PIK3CG; PIK3R1; PIK3R2; PIK3R3; PIK3R5; PLCG2; PRKCZ; PTPN6; RAC1; RAC2; RHOB; RHOG; SHC1; SYK; VAV1; VAV2; VAV3"
"R-HSA-156590","Glutathione conjugation",0.03603821379392,0.241172238464071,0.881214844073632,33,"AKR1A1; CHAC1; CHAC2; CNDP2; ESD; GCLC; GCLM; GGCT; GGT1; GGT5; GGT6; GGT7; GSS; GSTA1; GSTA2; GSTA3; GSTA4; GSTK1; GSTM1; GSTM2; GSTM3; GSTM4; GSTM5; GSTO1; GSTO2; GSTP1; GSTT2B; GSTZ1; HPGDS; MGST1; MGST2; MGST3; OPLAH"
"R-HSA-264876","Insulin processing",0.0424912038813284,0.288575402300737,0.882938864973611,23,"CPE; ERO1A; ERO1B; EXOC1; EXOC2; EXOC3; EXOC4; EXOC5; EXOC6; EXOC7; KIF5A; KIF5B; KIF5C; MYO5A; MYRIP; PCSK1; PCSK2; RAB27A; SLC30A5; SLC30A6; SLC30A8; STX1A; VAMP2"
"R-HSA-71406","Pyruvate metabolism and Citric Acid (TCA) cycle",0.0309399864882242,0.211474492379508,0.883679831729436,43,"ACO2; ADHFE1; BSG; CS; D2HGDH; DLAT; DLD; DLST; GLO1; HAGH; IDH2; IDH3A; IDH3B; L2HGDH; LDHA; LDHAL6A; LDHAL6B; LDHB; LDHC; MDH2; MPC1; MPC2; NNT; OGDH; PDHB; PDHX; PDK1; PDK2; PDK4; PDP1; PDPR; PPARD; RXRA; SDHA; SDHB; SDHC; SDHD; SLC16A1; SLC16A3; SLC16A8; SUCLA2; SUCLG1; SUCLG2"
"R-HSA-110373","Resolution of AP sites via the multiple-nucleotide patch replacement pathway",0.0421408302337488,0.288580875672665,0.883899442878111,23,"ADPRHL2; APEX1; LIG1; PARG; PARP1; PARP2; PCNA; POLB; POLD1; POLD2; POLD3; POLE; POLE2; POLE3; POLE4; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3"
"R-HSA-1912422","Pre-NOTCH Expression and Processing",0.031583063002687,0.216534454242409,0.884034288039239,41,"AGO1; AGO2; AGO3; AGO4; ATP2A1; ATP2A2; ATP2A3; B4GALT1; CCND1; E2F1; ELF3; EP300; FURIN; KAT2A; KAT2B; LFNG; MAML1; MAML2; MAML3; MFNG; MOV10; NOTCH1; NOTCH2; NOTCH3; NOTCH4; POFUT1; POGLUT1; PRKCI; RAB6A; RBPJ; RFNG; SEL1L; SNW1; ST3GAL3; ST3GAL4; ST3GAL6; TFDP1; TMED2; TNRC6A; TNRC6B; TNRC6C"
"R-HSA-5693554","Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)",-0.0393198285199818,0.271992361702405,0.885056502086717,26,"ATM; BARD1; BLM; BRCA1; BRCA2; BRIP1; DNA2; EXO1; KAT5; MRE11; NBN; PALB2; RAD50; RAD51; RAD51AP1; RAD51B; RAD51C; RAD51D; RBBP8; RMI1; RMI2; RTEL1; TOP3A; WRN; XRCC2; XRCC3"
"R-HSA-6804115","TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain",-0.0496715203281753,0.346441825445532,0.885993060461458,16,"CENPJ; CNOT1; CNOT11; CNOT2; CNOT3; CNOT4; CNOT6; CNOT6L; CNOT7; CNOT8; NPM1; PLAGL1; PLK2; PLK3; RGCC; TNKS1BP1"
"R-HSA-5205647","Mitophagy",0.0427018620519046,0.301950666146072,0.88753815835561,21,"ATG12; ATG5; CSNK2A2; CSNK2B; MAP1LC3A; MAP1LC3B; MFN1; MFN2; MTERF3; PGAM5; PINK1; SRC; TOMM20; TOMM22; TOMM5; TOMM7; TOMM70; UBA52; UBC; ULK1; VDAC1"
"R-HSA-2980766","Nuclear Envelope Breakdown",0.0276622160805006,0.202360912167874,0.891269963156039,47,"BANF1; CCNB1; CCNB2; CDK1; CNEP1R1; CTDNEP1; LEMD2; LEMD3; LMNA; LMNB1; LPIN1; LPIN2; LPIN3; NDC1; NEK6; NEK7; NEK9; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188; NUP205; NUP210; NUP214; NUP35; NUP43; NUP50; NUP54; NUP58; NUP62; NUP85; NUP88; NUP93; NUP98; NUPL2; PLK1; POM121; PRKCA; PRKCB; RAE1; RANBP2; SEH1L; TMPO; VRK1; VRK2"
"R-HSA-5617833","Cilium Assembly",0.0238099173366822,0.175003735730051,0.891778776840595,63,"ACTR1A; AHI1; AKAP9; ALMS1; ARF4; ARL13B; ARL3; ASAP1; ATAT1; B9D1; B9D2; BBIP1; BBS1; BBS10; BBS12; BBS2; BBS4; BBS5; BBS7; BBS9; C2CD3; CC2D2A; CCP110; CCT2; CCT3; CCT4; CCT5; CCT8; CDK1; CDK5RAP2; CENPJ; CEP131; CEP135; CEP152; CEP162; CEP164; CEP192; CEP250; CEP290; CEP41; CEP57; CEP63; CEP70; CEP72; CEP76; CEP78; CEP83; CEP89; CEP97; CKAP5; CLASP1; CLUAP1; CNGA4; CNTRL; CSNK1D; CSNK1E; CYS1; DCTN1; DCTN2; DYNC1H1; DYNC1I2; DYNC2H1; DYNC2LI1"
"R-HSA-381340","Transcriptional regulation of white adipocyte differentiation",-0.0253937046458386,0.187382216455019,0.892202158768038,55,"ADIPOQ; ADIRF; ANGPTL4; CARM1; CCNC; CCND3; CD36; CDK19; CDK4; CDK8; CEBPB; CHD9; EBF1; EP300; FABP4; FAM120B; HDAC3; KLF5; LPL; MED10; MED11; MED13; MED13L; MED15; MED16; MED17; MED19; MED20; MED21; MED22; MED23; MED24; MED25; MED26; MED27; MED28; MED29; MED30; MED31; MED4; MED6; MED7; MED8; MED9; NCOA1; NCOA2; NCOA3; NCOA6; NCOR1; NFKB1; PCK1; PLIN1; PPARA; PPARG; PPARGC1A"
"R-HSA-203927","MicroRNA (miRNA) biogenesis",0.0409155613655845,0.301979697521855,0.892223600619534,21,"AGO1; AGO2; AGO3; AGO4; BCDIN3D; DGCR8; DICER1; DROSHA; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; RAN; TARBP2"
"R-HSA-189445","Metabolism of porphyrins",-0.0467639256591454,0.346457503299826,0.892629759743637,16,"ALAD; ALAS1; BLVRA; BLVRB; COX10; COX15; CPOX; FECH; HMBS; HMOX1; HMOX2; PPOX; UGT1A1; UGT1A4; UROD; UROS"
"R-HSA-194315","Signaling by Rho GTPases",-0.0244272355122874,0.180973234782023,0.892630010301092,59,"A2M; ABI1; ABL1; ABR; ACTG1; ACTR2; ACTR3; AHCTF1; AKAP13; ARAP1; ARAP2; ARAP3; ARHGAP1; ARHGAP10; ARHGAP11A; ARHGAP11B; ARHGAP12; ARHGAP15; ARHGAP17; ARHGAP18; ARHGAP19; ARHGAP20; ARHGAP21; ARHGAP22; ARHGAP24; ARHGAP25; ARHGAP26; ARHGAP27; ARHGAP28; ARHGAP29; ARHGAP30; ARHGAP31; ARHGAP32; ARHGAP33; ARHGAP35; ARHGAP39; ARHGAP40; ARHGAP42; ARHGAP44; ARHGAP5; ARHGAP8; ARHGAP9; ARHGDIA; ARHGDIB; ARHGDIG; ARHGEF10; ARHGEF10L; ARHGEF11; ARHGEF12; ARHGEF15; ARHGEF16; ARHGEF17; ARHGEF18; ARHGEF19; ARHGEF2; ARHGEF26; ARHGEF3; ARHGEF33; ARHGEF35"
"R-HSA-421270","Cell-cell junction organization",-0.0249731877025883,0.185715736833958,0.893030963773189,56,"AFDN; ANG; CADM1; CADM2; CADM3; CDH1; CDH10; CDH11; CDH12; CDH13; CDH15; CDH17; CDH18; CDH2; CDH24; CDH3; CDH4; CDH5; CDH6; CDH7; CDH8; CLDN1; CLDN10; CLDN11; CLDN12; CLDN14; CLDN15; CLDN16; CLDN18; CLDN19; CLDN20; CLDN23; CLDN3; CLDN4; CLDN5; CLDN6; CLDN7; CLDN8; CLDN9; CRB3; CTNNA1; CTNNB1; CTNND1; F11R; JUP; MPP5; NECTIN1; NECTIN3; PARD3; PARD6A; PARD6B; PARD6G; PATJ; PRKCI; SDK1; SDK2"
"R-HSA-72165","mRNA Splicing - Minor Pathway",-0.0282235418189208,0.211760621166752,0.893971622136732,43,"DDX23; DDX42; EFTUD2; GTF2F1; GTF2F2; LSM2; NCBP1; NCBP2; PDCD7; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; PRPF6; PRPF8; RNPC3; SF3B1; SF3B2; SF3B3; SF3B5; SF3B6; SNRNP200; SNRNP25; SNRNP35; SNRNP48; SNRPB; SNRPD1; SNRPD3; SNRPE; SNRPF; SNU13; SRSF6; SRSF7; TXNL4A; ZCRB1; ZMAT5"
"R-HSA-5656121","Translesion synthesis by POLI",-0.0475942741313157,0.357790430878098,0.8941753728131,15,"MAD2L2; PCNA; POLI; REV1; REV3L; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3; UBA52; UBC"
"R-HSA-1839117","Signaling by cytosolic FGFR1 fusion mutants",0.0429445871338833,0.326039251069502,0.895208926847933,18,"BCR; CNTRL; CPSF6; CUX1; FGFR1OP; FGFR1OP2; GAB2; GRB2; LRRFIP1; MYO18A; PIK3CA; PIK3R1; STAT1; STAT3; STAT5A; STAT5B; TRIM24; ZMYM2"
"R-HSA-3134975","Regulation of innate immune responses to cytosolic DNA",0.0499593963555936,0.383418947087045,0.896329270829628,13,"DDX41; DTX4; IRF3; NLRP4; TBK1; TMEM173; TREX1; TRIM21; TRIM32; TRIM56; UBA52; UBC; ZBP1"
"R-HSA-72764","Eukaryotic Translation Termination",0.0243697102113568,0.188893348851135,0.897347309520074,54,"APEH; ETF1; FAU; GSPT1; N6AMT1; RPL10A; RPL12; RPL13; RPL13A; RPL14; RPL15; RPL17; RPL18; RPL18A; RPL19; RPL21; RPL22L1; RPL23A; RPL26; RPL26L1; RPL27A; RPL28; RPL29; RPL3; RPL30; RPL31; RPL32; RPL34; RPL35; RPL35A; RPL36; RPL36AL; RPL37; RPL38; RPL39L; RPL3L; RPL4; RPL41; RPL5; RPL7; RPL7A; RPL8; RPL9; RPLP0; RPLP2; RPS10; RPS11; RPS12; RPS13; RPS14; RPS15; RPS15A; RPS16; RPS18"
"R-HSA-6802952","Signaling by BRAF and RAF fusions",-0.0239265556043616,0.185715022621777,0.897488377911351,56,"AGGF1; AGK; AGTRAP; AKAP9; AP3B1; APBB1IP; ARRB1; ARRB2; ATG7; BCL2L11; BRAF; CLCN6; CNKSR1; CSK; ESRP1; FAM114A2; FAM131B; FGA; FGB; FGG; FN1; FXR1; HRAS; IQGAP1; ITGA2B; ITGB3; JAK2; KDM7A; KIAA1549; KRAS; KSR1; KSR2; LMNA; MAP2K1; MAP2K2; MAPK1; MAPK3; MARK3; MPRIP; NRAS; PAPD7; PAPSS1; PEBP1; QKI; RAF1; RAP1A; RAP1B; SND1; SRC; TLN1; TRAK1; TRIM24; VCL; VWF; YWHAB; ZC3HAV1"
"R-HSA-198933","Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell",0.0256572714746123,0.200240311705144,0.898044196832951,48,"B2M; C3; CD160; CD19; CD1D; CD200; CD200R1; CD22; CD226; CD247; CD300A; CD300C; CD300E; CD300LB; CD300LD; CD300LF; CD300LG; CD33; CD34; CD3D; CD3E; CD40; CD81; CD8A; CD8B; CD96; CDH1; CLEC2B; CLEC2D; CLEC4G; COLEC12; CRTAM; CXADR; FCGR1A; FCGR2B; FCGR3A; HCST; HLA-A; HLA-B; HLA-C; HLA-E; HLA-F; HLA-G; ICAM1; ICAM2; ICAM3; ICAM5; IFITM1"
"R-HSA-75205","Dissolution of Fibrin Clot",0.0486651898214283,0.383448674043458,0.899008084390885,13,"ANXA2; HRG; PLAT; PLAU; PLAUR; PLG; S100A10; SERPINB2; SERPINB6; SERPINB8; SERPINE1; SERPINE2; SERPINF2"
"R-HSA-3232118","SUMOylation of transcription factors",0.040420612588643,0.326083530216537,0.901348650212942,18,"CDKN2A; FOXL2; HIC1; MDM2; MITF; PIAS1; PIAS2; PIAS3; PIAS4; SP3; SUMO1; SUMO2; SUMO3; TFAP2A; TFAP2B; TFAP2C; TP53BP1; UBE2I"
"R-HSA-2514859","Inactivation, recovery and regulation of the phototransduction cascade",-0.0329694957086481,0.266937146665169,0.901702992882877,27,"CALM1; CAMKMT; CNGA1; FNTA; FNTB; GNAT1; GNB1; GNB5; GRK1; GRK4; GRK7; GUCA1A; GUCA1B; GUCA1C; METAP1; METAP2; NMT1; NMT2; PDE6A; PDE6B; PDE6G; PRKCA; PRKCQ; RCVRN; RGS9; RGS9BP; SAG"
"R-HSA-113501","Inhibition of replication initiation of damaged DNA by RB1/E2F1",-0.0527217142936683,0.43800663309388,0.90419212425267,10,"E2F1; POLA2; PPP2CA; PPP2CB; PPP2R1A; PPP2R1B; PRIM1; PRIM2; RB1; TFDP1"
"R-HSA-5218921","VEGFR2 mediated cell proliferation",0.0373977859777142,0.317472300279625,0.90622725517107,19,"AHCYL1; CALM1; HRAS; ITPR1; ITPR2; ITPR3; KDR; KRAS; NRAS; PDPK1; PLCG1; PRKCA; PRKCB; PRKCD; PRKCZ; RASA1; SPHK1; SRC; VEGFA"
"R-HSA-6804114","TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest",0.0415022137067432,0.357166433835866,0.907495203683355,15,"AURKA; BAX; CARM1; CCNB1; CDK1; E2F4; EP300; GADD45A; PCNA; PRMT1; RBL1; RBL2; SFN; TFDP1; ZNF385A"
"R-HSA-71064","Lysine catabolism",0.0455893539893483,0.399149164125973,0.90906630449162,12,"AADAT; AASS; ALDH7A1; CRYM; DLD; DLST; GCDH; HYKK; OGDH; PHYKPL; PIPOX; SLC25A21"
"R-HSA-211000","Gene Silencing by RNA",0.0236107658894149,0.206814366350647,0.909107748607654,45,"AGO1; AGO2; AGO3; AGO4; BCDIN3D; DDX4; DGCR8; DICER1; DROSHA; H2AFJ; H2AFV; H2AFX; H2AFZ; H2BFS; H3F3A; HENMT1; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HIST2H2AA3; HIST2H2AC; HSP90AA1; IPO8; MAEL; MOV10L1; MYBL1; NDC1; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188; NUP205; NUP210; NUP214; NUP35; NUP43; NUP50; NUP54; NUP58; NUP62; NUP85; NUP88"
"R-HSA-2559584","Formation of Senescence-Associated Heterochromatin Foci (SAHF)",-0.0447577266042863,0.399953613583147,0.910896913193669,12,"ASF1A; CABIN1; EP400; H1F0; HIST1H1C; HIST1H1D; HIST1H1E; HMGA1; HMGA2; LMNB1; RB1; UBN1"
"R-HSA-2132295","MHC class II antigen presentation",0.0196581705351386,0.176424073385728,0.911278805296061,62,"ACTR10; ACTR1A; ACTR1B; AP1B1; AP1G1; AP1M1; AP1M2; AP1S1; AP1S3; AP2A1; AP2A2; AP2B1; AP2M1; AP2S1; CANX; CAPZA1; CAPZA2; CAPZA3; CAPZB; CENPE; CLTA; CLTC; CTSA; CTSB; CTSC; CTSD; CTSE; CTSF; CTSH; CTSK; CTSL; CTSO; CTSS; CTSV; DCTN1; DCTN2; DCTN4; DCTN5; DCTN6; DNM1; DNM2; DNM3; DYNC1H1; DYNC1I1; DYNC1I2; DYNC1LI1; DYNC1LI2; DYNLL1; DYNLL2; HLA-DMA; HLA-DMB; HLA-DOA; HLA-DOB; HLA-DPA1; HLA-DPB1; HLA-DQA1; HLA-DQA2; HLA-DQB1; HLA-DQB2; HLA-DRA; HLA-DRB1; HLA-DRB5"
"R-HSA-8941856","RUNX3 regulates NOTCH signaling",-0.0434412858473879,0.399960167070938,0.913508631741349,12,"EP300; HES1; JAG1; KAT2A; KAT2B; MAML1; MAML2; MAML3; NOTCH1; RBPJ; RUNX3; SNW1"
"R-HSA-3371453","Regulation of HSF1-mediated heat shock response",0.0200160081535999,0.185549280323551,0.914095363477793,56,"ATM; ATR; BAG1; BAG2; BAG3; BAG5; CCAR2; CRYBA4; DNAJB1; DNAJB6; DNAJC2; DNAJC7; FKBP4; GSK3B; HIKESHI; HSBP1; HSF1; HSPA12A; HSPA12B; HSPA13; HSPA14; HSPA1B; HSPA1L; HSPA2; HSPA4; HSPA4L; HSPA6; HSPA8; HSPH1; MAPK1; MAPK3; MAPKAPK2; MRPL18; NDC1; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188; NUP205; NUP210; NUP214; NUP35; NUP43; NUP50; NUP54; NUP58; NUP62; NUP85; NUP88; NUP93; NUP98; NUPL2; POM121; RAE1"
"R-HSA-382551","Transport of small molecules",-0.0188485217033185,0.176573827848276,0.914990614704864,62,"A2M; ABCA1; ABCA10; ABCA2; ABCA3; ABCA4; ABCA5; ABCA6; ABCA7; ABCA8; ABCA9; ABCB1; ABCB10; ABCB4; ABCB6; ABCB8; ABCB9; ABCC1; ABCC10; ABCC11; ABCC2; ABCC3; ABCC4; ABCC5; ABCC6; ABCC8; ABCC9; ABCD2; ABCD3; ABCF1; ABCG1; ABCG2; ABCG4; ABCG5; ABCG8; ACO1; ADCY1; ADCY2; ADCY3; ADCY4; ADCY5; ADCY6; ADCY7; ADCY9; ADD1; ADD2; ADD3; AHCYL2; AKAP1; ALAD; ALB; AMN; ANGPTL3; ANGPTL4; ANGPTL8; ANKH; ANO1; ANO10; ANO2; ANO3; ANO4; ANO5"
"R-HSA-159231","Transport of Mature mRNA Derived from an Intronless Transcript",0.024636866727814,0.234332548056946,0.916267622978279,35,"ALYREF; CPSF1; CPSF2; CPSF3; CPSF4; EIF4E; FIP1L1; NCBP1; NCBP2; NDC1; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188; NUP205; NUP210; NUP214; NUP35; NUP43; NUP50; NUP54; NUP58; NUP62; NUP85; NUP88; NUP93; NUP98; NUPL2; NXF1; POM121; RAE1; RANBP2; SEH1L"
"R-HSA-5357956","TNFR1-induced NFkappaB signaling pathway",-0.032465384520666,0.309980637233454,0.916587208707996,20,"BIRC2; BIRC3; CHUK; CYLD; IKBKB; MAP3K7; RACK1; RBCK1; RIPK1; RNF31; SHARPIN; TAB1; TAB2; TNF; TNFAIP3; TNFRSF1A; TRAF1; TRAF2; USP2; USP4"
"R-HSA-381426","Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)",0.0197038051050267,0.190685652448858,0.917699998363579,53,"ADAM10; ALB; AMTN; ANO8; APLP2; APOA1; APOA2; APOB; APOL1; APP; BMP4; BPIFB2; C3; C4A; CALU; CDH2; CHGB; CKAP4; CP; CSF1; CST3; CTSG; DNAJC3; EVA1A; F2; F5; FAM20A; FAM20C; FBN1; FGA; FGG; FN1; FSTL1; FSTL3; FUCA2; GAS6; GOLM1; HRC; HSP90B1; IGF1; IGF2; IGFALS; IGFBP1; IGFBP2; IGFBP3; IGFBP4; IGFBP5; IGFBP6; IGFBP7; ITIH2; KLK1; KLK13; KLK2"
"R-HSA-3000170","Syndecan interactions",0.0326789239799058,0.31754533303139,0.918033566798639,19,"ACTN1; FGF2; ITGA2; ITGA6; ITGAV; ITGB1; ITGB3; ITGB4; ITGB5; PRKCA; SDC1; SDC2; SDC3; SDC4; TGFB1; THBS1; TNC; TRAPPC4; VTN"
"R-HSA-1912408","Pre-NOTCH Transcription and Translation",-0.0285033737210632,0.277370700591085,0.918151276304875,25,"AGO1; AGO2; AGO3; AGO4; CCND1; E2F1; ELF3; EP300; KAT2A; KAT2B; MAML1; MAML2; MAML3; MOV10; NOTCH1; NOTCH2; NOTCH3; NOTCH4; PRKCI; RBPJ; SNW1; TFDP1; TNRC6A; TNRC6B; TNRC6C"
"R-HSA-2173791","TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)",-0.0393005010677829,0.384312710516539,0.918548892986539,13,"ARHGEF18; CGN; F11R; FKBP1A; PARD3; PARD6A; PRKCZ; SMURF1; TGFB1; TGFBR1; TGFBR2; UBA52; UBC"
"R-HSA-909733","Interferon alpha/beta signaling",0.0205284994210593,0.20241825766243,0.91922004206264,47,"ABCE1; ADAR; BST2; EGR1; HLA-A; HLA-B; HLA-C; HLA-E; HLA-F; HLA-G; IFI35; IFIT1; IFIT3; IFITM1; IFITM2; IFITM3; IFNAR1; IFNAR2; IP6K2; IRF1; IRF3; IRF4; IRF5; IRF6; IRF7; IRF8; IRF9; ISG15; ISG20; JAK1; MX1; MX2; OAS1; OAS2; OAS3; OASL; PSMB8; PTPN1; PTPN6; RNASEL; RSAD2; SOCS1; SOCS3; STAT1; STAT2; TYK2; USP18"
"R-HSA-69306","DNA Replication",-0.0181414682356372,0.185708345000072,0.922180081239434,56,"CCNA1; CCNA2; CDC45; CDC6; CDC7; CDK2; CDKN1B; CDT1; DBF4; DNA2; E2F1; E2F2; FZR1; GINS1; GINS2; GINS3; GMNN; LIG1; MCM10; MCM2; MCM3; MCM4; MCM5; MCM6; MCM7; MCM8; ORC1; ORC3; ORC4; ORC5; ORC6; PCNA; POLA2; POLD1; POLD2; POLD3; POLE; POLE2; POLE3; POLE4; PRIM1; PRIM2; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6; PSMB1; PSMB10; PSMB2; PSMB4; PSMB5; PSMB7; PSMB8; PSMB9"
"R-HSA-162906","HIV Infection",0.017522002450138,0.182365983399349,0.923455821466555,58,"AP1B1; AP1G1; AP1M1; AP1M2; AP1S1; AP1S3; AP2A1; AP2A2; AP2B1; AP2M1; AP2S1; APOBEC3G; ATP6V1H; B2M; BANF1; BTRC; CCNH; CCNK; CCNT1; CCNT2; CCR5; CD247; CD28; CD4; CD8B; CDK7; CDK9; CHMP2A; CHMP2B; CHMP3; CHMP4A; CHMP4B; CHMP4C; CHMP5; CHMP6; CHMP7; CTDP1; CUL5; CXCR4; DOCK2; ELL; ELMO1; ELOA; ELOC; ERCC3; FURIN; FYN; GTF2A1; GTF2A2; GTF2B; GTF2E1; GTF2E2; GTF2F1; GTF2F2; GTF2H1; GTF2H2; GTF2H3; GTF2H4"
"R-HSA-193692","Regulated proteolysis of p75NTR",-0.041365399739096,0.438080533429671,0.92477220041771,10,"ADAM17; APH1A; APH1B; NCSTN; NFKB1; NGFR; PSEN1; PSEN2; RELA; TRAF6"
"R-HSA-2514856","The phototransduction cascade",0.0247043140332239,0.261862100753893,0.924838337698424,28,"CALM1; CAMKMT; CNGA1; FNTA; FNTB; GNAT1; GNB1; GNB5; GRK1; GRK4; GRK7; GUCA1A; GUCA1B; GUCA1C; METAP1; METAP2; NMT1; NMT2; PDE6A; PDE6B; PDE6G; PRKCA; PRKCQ; RCVRN; RGS9; RGS9BP; SAG; SLC24A1"
"R-HSA-429947","Deadenylation of mRNA",-0.0269385977276611,0.289134480590454,0.925768677108735,23,"CNOT1; CNOT11; CNOT2; CNOT3; CNOT4; CNOT6; CNOT6L; CNOT7; CNOT8; EIF4A1; EIF4A2; EIF4A3; EIF4B; EIF4E; EIF4G1; PABPC1; PAIP1; PAN2; PAN3; PARN; TNKS1BP1; ZCCHC11; ZCCHC6"
"R-HSA-162594","Early Phase of HIV Life Cycle",0.0349547700864375,0.383733620123972,0.927420095657833,13,"BANF1; CCR5; CD4; CXCR4; HMGA1; KPNA1; LIG1; LIG4; PPIA; PSIP1; XRCC4; XRCC5; XRCC6"
"R-HSA-211958","Miscellaneous substrates",-0.0363795858945984,0.399985969229231,0.92753060814462,12,"CYP2D6; CYP2S1; CYP2U1; CYP2W1; CYP3A43; CYP4A11; CYP4A22; CYP4B1; CYP4F11; CYP4F2; CYP4F22; CYP4F3"
"R-HSA-114452","Activation of BH3-only proteins",-0.0238142482298632,0.262145310289354,0.927616791141723,28,"AKT1; AKT2; AKT3; BAD; BBC3; BCL2; BCL2L11; BID; BMF; DYNLL1; DYNLL2; E2F1; MAPK8; PMAIP1; PPP1R13B; PPP3CC; PPP3R1; SFN; TFDP1; TP53BP2; TP63; TP73; YWHAB; YWHAE; YWHAG; YWHAH; YWHAQ; YWHAZ"
"R-HSA-4641265","Repression of WNT target genes",0.0331819050369756,0.369832520907443,0.928508580785758,14,"AES; AXIN2; CTBP1; CTBP2; HDAC1; LEF1; MYC; TCF7; TCF7L1; TCF7L2; TLE1; TLE2; TLE3; TLE4"
"R-HSA-1500620","Meiosis",0.0185404273250088,0.20685373204611,0.928580754652145,45,"ACD; ATM; ATR; BLM; BRCA1; BRCA2; CDK2; CDK4; DIDO1; DMC1; H2AFJ; H2AFV; H2AFX; H2AFZ; H2BFS; H3F3A; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HIST2H2AA3; HIST2H2AC; HSPA2; LMNA; LMNB1; MLH1; MLH3; MND1; MRE11; MSH4; MSH5; NBN; POT1; PSMC3IP; RAD21; RAD50; RAD51; RAD51C; RBBP8; REC8; RPA1; RPA2; RPA3; SMC3; STAG1"
"R-HSA-180746","Nuclear import of Rev protein",-0.0227628174071961,0.257603041765966,0.929587428015924,29,"KPNB1; NDC1; NPM1; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188; NUP205; NUP210; NUP214; NUP35; NUP43; NUP50; NUP54; NUP58; NUP62; NUP85; NUP88; NUP93; NUP98; NUPL2; POM121; RAE1; RAN; RANBP2; RCC1; SEH1L"
"R-HSA-212300","PRC2 methylates histones and DNA",0.0239997408171591,0.282768470137207,0.932361422494473,24,"AEBP2; DNMT1; DNMT3A; DNMT3B; EED; EZH2; H2AFJ; H2AFV; H2AFX; H2AFZ; H2BFS; H3F3A; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HIST2H2AA3; HIST2H2AC; JARID2; MTF2; PHF1; PHF19; RBBP4; SUZ12"
"R-HSA-373755","Semaphorin interactions",0.0155823152794154,0.185577957258185,0.933083136506317,56,"ARHGAP35; ARHGEF11; ARHGEF12; CD72; CDK5R1; CFL1; CRMP1; DPYSL2; DPYSL4; DPYSL5; ERBB2; FARP2; FES; FYN; GSK3B; HSP90AA1; HSP90AB1; ITGA1; ITGB1; LIMK1; LIMK2; MET; MYH10; MYH11; MYH14; MYH9; MYL12B; MYL6; MYL9; NRP1; PAK1; PAK2; PIP5K1C; PLXNA1; PLXNA2; PLXNA4; PLXNB1; PLXNC1; PLXND1; PTPRC; RAC1; RHOB; RHOC; ROCK1; ROCK2; RRAS; SEMA3A; SEMA3E; SEMA4A; SEMA4D; SEMA5A; SEMA6A; SEMA6D; SEMA7A; TLN1; TREM2"
"R-HSA-933543","NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10",-0.0347572160475673,0.417745743837102,0.933691046835541,11,"CASP10; CASP8; CHUK; DDX58; FADD; IFIH1; IKBKB; MAVS; RIPK1; RNF135; TRIM25"
"R-HSA-75892","Platelet Adhesion to exposed collagen",-0.0345493682381903,0.417746179128622,0.934086736271751,11,"FCER1G; FYN; GP1BA; GP5; GP6; ITGA1; ITGA10; ITGA2; ITGB1; LYN; VWF"
"R-HSA-381070","IRE1alpha activates chaperones",-0.0163152659033152,0.198414335214598,0.934465199863147,49,"ACADVL; ADD1; ARFGAP1; ATP6V0D1; CTDSP2; CUL7; CXXC1; DCTN1; DDX11; DNAJB11; DNAJB9; DNAJC3; EDEM1; ERN1; EXTL1; EXTL2; EXTL3; FKBP14; GFPT1; GOSR2; HDGF; KDELR3; KLHDC3; LMNA; MYDGF; PDIA5; PDIA6; PLA2G4B; PPP2R5B; PREB; SEC61A1; SEC61A2; SEC61B; SEC61G; SEC62; SEC63; SERP1; SHC1; SRPRB; SSR1; SULT1A3; SYVN1; TATDN2; TLN1; TPP1; WFS1; WIPI1; XBP1; YIF1A"
"R-HSA-216083","Integrin cell surface interactions",0.0142315094837273,0.176456740827652,0.935719069501827,62,"AGRN; BSG; CD44; CD47; CDH1; COL13A1; COL16A1; COL18A1; COL23A1; COL4A1; COL4A2; COL4A3; COL4A4; COL9A1; COL9A2; COL9A3; COMP; F11R; FBN1; FGA; FGB; FGG; FN1; HSPG2; IBSP; ICAM1; ICAM2; ICAM3; ICAM5; ITGA1; ITGA10; ITGA11; ITGA2; ITGA2B; ITGA3; ITGA4; ITGA5; ITGA6; ITGA7; ITGA8; ITGA9; ITGAD; ITGAE; ITGAM; ITGAV; ITGAX; ITGB1; ITGB2; ITGB3; ITGB5; ITGB6; ITGB7; ITGB8; JAM3; KDR; LUM; MADCAM1; SPP1; THBS1; TNC; VCAM1; VTN"
"R-HSA-388844","Receptor-type tyrosine-protein phosphatases",-0.0277866957737254,0.346503223464258,0.936084760980271,16,"IL1RAP; LRRC4B; NTRK3; PPFIA1; PPFIA2; PPFIA3; PPFIA4; PPFIBP1; PPFIBP2; PTPRD; PTPRF; PTPRS; SLITRK1; SLITRK3; SLITRK5; SLITRK6"
"R-HSA-416572","Sema4D induced cell migration and growth-cone collapse",-0.0255377767221754,0.326678803535909,0.937689673084173,18,"ARHGEF11; ARHGEF12; ERBB2; LIMK1; LIMK2; MYH10; MYH11; MYH14; MYH9; MYL12B; MYL6; MYL9; PLXNB1; RHOB; RHOC; ROCK1; ROCK2; SEMA4D"
"R-HSA-171007","p38MAPK events",0.0298088630716442,0.383826391974076,0.938096636750656,13,"HRAS; KRAS; MAPK11; MAPK12; MAPK13; MAPK14; MAPKAPK2; MAPKAPK3; NRAS; RALA; RALB; RALGDS; SRC"
"R-HSA-168276","NS1 Mediated Effects on Host Pathways",0.0181582951502148,0.234390272321978,0.938249381995246,35,"CPSF4; EIF2AK2; ISG15; KPNA1; KPNA2; KPNA3; KPNA4; KPNA5; KPNA7; KPNB1; NDC1; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188; NUP205; NUP210; NUP214; NUP35; NUP43; NUP50; NUP54; NUP58; NUP62; NUP85; NUP88; NUP93; NUP98; NUPL2; POM121; RAE1; RANBP2; SEH1L"
"R-HSA-437239","Recycling pathway of L1",-0.0227373671460065,0.295605272043588,0.938688775802944,22,"AP2A1; AP2A2; AP2B1; AP2M1; AP2S1; CLTA; CLTC; DNM1; DNM2; DNM3; DPYSL2; EZR; MAPK1; NUMB; RDX; RPS6KA1; RPS6KA2; RPS6KA4; RPS6KA5; SH3GL2; SHTN1; SRC"
"R-HSA-3270619","IRF3-mediated induction of type I IFN",0.0296879819709809,0.399473197694521,0.940757488430744,12,"DDX41; DTX4; IFI16; IRF3; MRE11; NLRP4; PRKDC; TBK1; TMEM173; TREX1; XRCC5; XRCC6"
"R-HSA-8866910","TFAP2 (AP-2) family regulates transcription of growth factors and their receptors",-0.0276905632558861,0.384330804808921,0.94256309272401,13,"ATAD2; CGA; CGB3; EGFR; ERBB2; ESR1; KIT; TFAP2A; TFAP2B; TFAP2C; TGFA; VEGFA; YY1"
"R-HSA-5358351","Signaling by Hedgehog",-0.0125671845066745,0.175168318146595,0.942806054269623,63,"ADAM17; ADCY1; ADCY10; ADCY2; ADCY3; ADCY4; ADCY5; ADCY6; ADCY7; ADCY9; ARRB1; ARRB2; BOC; BTRC; CDC73; CDON; CSNK1A1; CUL1; CUL3; DERL2; DHH; DISP2; DYNC2H1; DZIP1; EFCAB7; ERLEC1; EVC; EVC2; FUZ; GAS1; GAS8; GLI1; GLI2; GLI3; GNAS; GPC5; GPR161; GSK3B; HHAT; HHIP; IFT122; IFT140; IFT172; IFT52; IFT57; IFT88; IHH; INTU; IQCE; ITCH; KIF3A; KIF7; MKS1; NOTUM; NUMB; OS9; P4HB; PRKACB; PRKAR1A; PRKAR1B; PRKAR2A; PRKAR2B; PSMA1"
"R-HSA-168273","Influenza Viral RNA Transcription and Replication",0.0135044225044263,0.19072588690813,0.94355263490559,53,"DNAJC3; FAU; GRSF1; GTF2F1; GTF2F2; HSP90AA1; IPO5; NDC1; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188; NUP205; NUP210; NUP214; NUP35; NUP43; NUP50; NUP54; NUP58; NUP62; NUP85; NUP88; NUP93; NUP98; NUPL2; POLR2A; POLR2B; POLR2C; POLR2D; POLR2E; POLR2F; POLR2H; POLR2I; POLR2J; POLR2K; POLR2L; POM121; RAE1; RANBP2; RPL10A; RPL12; RPL13; RPL13A; RPL14; RPL15; RPL17; RPL18; RPL18A; RPL19; RPL21"
"R-HSA-1660516","Synthesis of PIPs at the early endosome membrane",0.0251064185769841,0.357445347896917,0.944003845864872,15,"FIG4; INPP4A; INPP4B; INPP5F; MTMR10; MTMR12; MTMR2; MTMR4; PI4K2A; PI4K2B; PIK3C2A; PIK3C3; PIK3R4; PIKFYVE; VAC14"
"R-HSA-3371378","Regulation by c-FLIP",0.0294862615362877,0.437541048714691,0.946270556268431,10,"CASP8; CFLAR; FADD; FAS; FASLG; RIPK1; TNFRSF10A; TNFRSF10B; TNFSF10; TRAF2"
"R-HSA-5218900","CASP8 activity is inhibited",0.0294862615362877,0.437541048714691,0.946270556268431,10,"CASP8; CFLAR; FADD; FAS; FASLG; RIPK1; TNFRSF10A; TNFRSF10B; TNFSF10; TRAF2"
"R-HSA-69416","Dimerization of procaspase-8",0.0294862615362877,0.437541048714691,0.946270556268431,10,"CASP8; CFLAR; FADD; FAS; FASLG; RIPK1; TNFRSF10A; TNFRSF10B; TNFSF10; TRAF2"
"R-HSA-1660514","Synthesis of PIPs at the Golgi membrane",-0.0240009371000738,0.35783958544199,0.946524561479704,15,"ARF3; FIG4; INPP5E; PI4K2A; PI4K2B; PI4KA; PI4KB; PIK3C2A; PIK3C2G; PIK3C3; PIK3R4; PIKFYVE; SACM1L; TPTE2; VAC14"
"R-HSA-5205685","Pink/Parkin Mediated Mitophagy",0.0228655386656691,0.346150400823674,0.947332717299416,16,"ATG12; ATG5; MAP1LC3A; MAP1LC3B; MFN1; MFN2; MTERF3; PINK1; TOMM20; TOMM22; TOMM5; TOMM7; TOMM70; UBA52; UBC; VDAC1"
"R-HSA-445144","Signal transduction by L1",-0.0206355880967664,0.317995677657459,0.948259457976015,19,"CSNK2A2; CSNK2B; EGFR; FGFR1; ITGA2B; ITGA5; ITGA9; ITGAV; ITGB1; ITGB3; MAP2K1; MAP2K2; MAPK1; MAPK3; NCAM1; NRP1; PAK1; RAC1; VAV2"
"R-HSA-1660517","Synthesis of PIPs at the late endosome membrane",-0.0278572683681796,0.438110177430924,0.949300616338172,10,"FIG4; MTMR2; MTMR4; MTMR7; MTMR9; PIK3C2A; PIK3C3; PIK3R4; PIKFYVE; VAC14"
"R-HSA-8953897","Cellular responses to external stimuli",0.0113037833516778,0.177900400786456,0.94933654450345,61,"ACD; ACTR10; ACTR1A; AGO1; AGO3; AGO4; AJUBA; AKT1S1; ANAPC1; ANAPC10; ANAPC11; ANAPC15; ANAPC16; ANAPC2; ANAPC4; ANAPC5; ANAPC7; AQP8; ARNT; ASF1A; ATG10; ATG101; ATG12; ATG13; ATG14; ATG16L1; ATG4B; ATG4C; ATG4D; ATG5; ATG7; ATG9A; ATG9B; ATM; ATOX1; ATR; BAG1; BAG2; BAG3; BAG5; BECN1; BMI1; CA9; CABIN1; CAMK2A; CAMK2B; CAMK2D; CAMK2G; CAPZA1; CAPZA2; CAPZA3; CAPZB; CAT; CBX2; CBX4; CBX6; CBX8; CCAR2; CCNA1; CCNA2; CCNE1"
"R-HSA-168249","Innate Immune System",-0.0110414186099925,0.176558963883764,0.950135420270714,62,"A1BG; ABCA13; ABI1; ABL1; ACAA1; ACLY; ACPP; ACTG1; ACTR10; ACTR1B; ACTR2; ACTR3; ADAM10; ADAM8; ADGRG3; AGA; AGER; AGL; AGPAT2; AHCYL1; AIM2; ALAD; ALDH3B1; ALDOC; ALOX5; AMPD3; ANO6; ANPEP; ANXA2; AOC1; AP1M1; AP2A2; APAF1; APEH; APOB; APP; APRT; ARG1; ARHGAP9; ARL8A; ARMC8; ARPC1A; ARPC1B; ARPC2; ARPC3; ARPC4; ARPC5; ARSA; ARSB; ART1; ASAH1; ATAD3B; ATF1; ATF2; ATG12; ATG5; ATG7; ATOX1; ATP11A; ATP11B; ATP6V0A1; ATP6V0A2"
"R-HSA-8948700","Competing endogenous RNAs (ceRNAs) regulate PTEN translation",-0.0272814900634558,0.438110040756768,0.950347131868578,10,"AGO1; AGO2; AGO3; AGO4; CNOT6L; MOV10; TNRC6A; TNRC6B; TNRC6C; VAPA"
"R-HSA-418597","G alpha (z) signalling events",0.013166207178171,0.219365086952316,0.9521400155546,40,"ADCY1; ADCY2; ADCY3; ADCY4; ADCY5; ADCY6; ADCY7; ADCY9; ADRA2A; ADRA2C; GNAI1; GNAI2; GNAI3; GNAS; GNAT3; GNAZ; GNB1; GNB2; GNB3; GNB4; GNB5; GNG10; GNG11; GNG12; GNG2; GNG3; GNG4; GNG5; GNG7; GNGT2; PRKCA; PRKCB; PRKCD; PRKCE; PRKCH; PRKCQ; RGS17; RGS19; RGS20; RGS4"
"R-HSA-193704","p75 NTR receptor-mediated signalling",-0.0108869220361966,0.182491420080163,0.952428682739074,58,"ABR; ADAM17; AKAP13; APH1A; APH1B; ARHGDIA; ARHGEF10; ARHGEF10L; ARHGEF11; ARHGEF12; ARHGEF15; ARHGEF16; ARHGEF17; ARHGEF18; ARHGEF19; ARHGEF2; ARHGEF26; ARHGEF3; ARHGEF33; ARHGEF35; ARHGEF37; ARHGEF38; ARHGEF39; ARHGEF4; ARHGEF40; ARHGEF5; ARHGEF7; BAD; BCL2L11; CASP3; ECT2; FGD2; FGD3; FGD4; GNA13; HDAC1; HDAC2; HDAC3; IKBKB; ITGB3BP; ITSN1; KALRN; LINGO1; MAG; MAPK8; MCF2L; MYD88; NCSTN; NET1; NFKB1; NFKBIA; NGEF; NGF; NGFR; OBSCN; OMG; PLEKHG2; PLEKHG5"
"R-HSA-1280215","Cytokine Signaling in Immune system",0.010501644490563,0.182407020253391,0.954089083892984,58,"ABCE1; ADAM17; ADAR; AGER; AIP; AKT1; ALOX15; ALOX5; ANXA1; ANXA2; APP; ARIH1; ATF1; ATF2; B2M; BATF; BCL2; BCL2L1; BIRC2; BIRC3; BIRC5; BLNK; BOLA2; BRWD1; BST2; BTRC; CA1; CAMK2A; CAMK2B; CAMK2D; CAMK2G; CANX; CAPZA1; CASP1; CASP3; CBL; CCL11; CCL19; CCL2; CCL20; CCL22; CCND1; CCR1; CCR2; CCR5; CD27; CD36; CD4; CD40; CD44; CD70; CD80; CD86; CDC42; CFL1; CHUK; CIITA; CISH"
"R-HSA-1839124","FGFR1 mutant receptor activation",0.014652524359684,0.271808803410571,0.957008886752011,26,"BCR; CNTRL; CPSF6; CUX1; ERLIN2; FGF1; FGF17; FGF2; FGF20; FGF5; FGF9; FGFR1; FGFR1OP; FGFR1OP2; GAB2; GRB2; LRRFIP1; MYO18A; PIK3CA; PIK3R1; STAT1; STAT3; STAT5A; STAT5B; TRIM24; ZMYM2"
"R-HSA-5693616","Presynaptic phase of homologous DNA pairing and strand exchange",-0.0117384031903481,0.222268391014275,0.957881825965235,39,"ATM; ATR; ATRIP; BARD1; BLM; BRCA1; BRCA2; BRIP1; CHEK1; DNA2; EXO1; HUS1; KAT5; MRE11; NBN; RAD1; RAD17; RAD50; RAD51; RAD51B; RAD51C; RAD51D; RAD9A; RAD9B; RBBP8; RFC2; RFC3; RFC4; RFC5; RHNO1; RMI1; RMI2; RPA1; RPA2; RPA3; TOP3A; TOPBP1; WRN; XRCC2"
"R-HSA-1295596","Spry regulation of FGF signaling",0.0209812784976144,0.399617925916786,0.95812762876234,12,"BRAF; CBL; GRB2; MAPK1; MAPK3; MKNK1; PPP2CA; PPP2CB; PPP2R1A; SRC; UBA52; UBC"
"R-HSA-418038","Nucleotide-like (purinergic) receptors",-0.0205772875152711,0.399986837971726,0.958970997859643,12,"ADORA1; ADORA2A; ADORA2B; GPR17; LPAR6; P2RY1; P2RY11; P2RY12; P2RY13; P2RY14; P2RY2; P2RY6"
"R-HSA-450321","JNK (c-Jun kinases) phosphorylation and  activation mediated by activated human TAK1",-0.0181566198108125,0.357827662400054,0.959531713044044,15,"IRAK2; MAP2K4; MAP2K7; MAP3K7; MAPK10; MAPK8; MAPK9; NOD1; NOD2; RIPK2; TAB1; TAB2; TRAF6; UBE2N; UBE2V1"
"R-HSA-5140745","WNT5A-dependent internalization of FZD2, FZD5 and ROR2",0.0193463144262857,0.383991056016628,0.959817820206853,13,"AP2A1; AP2A2; AP2B1; AP2M1; AP2S1; CLTA; CLTB; CLTC; FZD2; FZD5; ROR1; ROR2; WNT5A"
"R-HSA-432722","Golgi Associated Vesicle Biogenesis",-0.00967791572555194,0.200436544902047,0.961489756363526,48,"ACBD3; AP1B1; AP1G1; AP1M1; AP1M2; AP1S1; AP1S3; AP3B1; AP3S1; AP4B1; AP4E1; ARRB1; BLOC1S1; BLOC1S4; BLOC1S6; CLINT1; CLTA; CLTC; CPD; DNAJC6; DNM2; DTNBP1; FTH1; FTL; GAK; GOLGB1; HIP1R; HSPA8; IGF2R; NAPA; PICALM; PIK3C2A; PUM1; RAB5C; SH3D19; SH3GL2; SNAPIN; SNX2; SNX5; SNX9; SORT1; TFRC; TGOLN2; TPD52; TPD52L1; TXNDC5; VAMP2; VAMP8"
"R-HSA-442729","CREB phosphorylation through the activation of CaMKII",0.0182210541773739,0.384006848259982,0.962154726517148,13,"ACTN2; AKAP9; CALM1; CAMK2A; CAMK2B; CAMK2D; CAMK2G; DLG4; GRIN1; GRIN2A; GRIN2B; GRIN2C; GRIN2D"
"R-HSA-5423646","Aflatoxin activation and detoxification",-0.0154375077811188,0.336158718133904,0.963371406475922,17,"ACY1; ACY3; AKR7A2; AKR7A3; CYP1A2; CYP2A13; CYP3A5; DPEP1; DPEP2; DPEP3; GGT1; GGT5; GGT6; GGT7; MGST1; MGST2; MGST3"
"R-HSA-112308","Presynaptic depolarization and calcium channel opening",0.0176041964420163,0.399667809761495,0.964866882923609,12,"CACFD1; CACNA1A; CACNA1B; CACNA1E; CACNA2D1; CACNA2D2; CACNA2D3; CACNB1; CACNB2; CACNB3; CACNB4; CACNG4"
"R-HSA-879415","Advanced glycosylation endproduct receptor signaling",-0.017487998865116,0.399977862667577,0.965125670193354,12,"AGER; APP; CAPZA1; CAPZA2; DDOST; LGALS3; MAPK1; MAPK3; PRKCSH; S100A12; S100B; SAA1"
"R-HSA-199991","Membrane Trafficking",-0.00758719937996615,0.175155784857654,0.965448947999819,63,"AAK1; ACBD3; ACTR10; ACTR1A; ACTR2; ACTR3; ADRB2; AGFG1; AGPAT3; AGTR1; AKT1; AKT2; AKT3; ALS2; ALS2CL; AMPH; ANK1; ANK2; ANK3; ANKRD27; ANKRD28; AP1B1; AP1G1; AP1G2; AP1M1; AP1M2; AP1S1; AP1S3; AP2A1; AP2A2; AP2B1; AP2M1; AP2S1; AP3B1; AP3S1; AP4B1; AP4E1; AP4M1; AP4S1; APOB; APP; ARCN1; AREG; ARF3; ARF4; ARF5; ARF6; ARFGAP1; ARFGAP2; ARFGAP3; ARFIP2; ARFRP1; ARL1; ARPC1A; ARPC2; ARPC3; ARPC4; ARPC5; ARRB1; ARRB2; ASPSCR1; BET1; BET1L"
"R-HSA-8856688","Golgi-to-ER retrograde transport",-0.00757862388032146,0.176549836971803,0.965760317052037,62,"ACTR10; ACTR1A; AGPAT3; ARCN1; ARF3; ARF4; ARF5; ARFGAP1; ARFGAP2; ARFGAP3; BICD1; BICD2; BNIP1; CAPZA1; CAPZA2; CAPZA3; CAPZB; CENPE; COPA; COPB1; COPB2; COPE; COPG1; COPG2; COPZ1; COPZ2; DCTN1; DCTN2; DCTN4; DCTN5; DCTN6; DYNC1H1; DYNC1I1; DYNC1I2; DYNC1LI1; DYNC1LI2; DYNLL1; DYNLL2; GALNT1; GALNT2; GBF1; KDELR1; KDELR2; KDELR3; KIF11; KIF12; KIF13B; KIF15; KIF16B; KIF18B; KIF19; KIF1A; KIF1B; KIF1C; KIF20A; KIF20B; KIF21A; KIF21B; KIF25; KIF26A; KIF26B; KIF27"
"R-HSA-6806834","Signaling by MET",0.00742829613024848,0.17649235738284,0.966428158800817,62,"ARF6; CBL; CRK; CRKL; DOCK7; EPS15; GAB1; GGA3; GRB2; HGF; HGFAC; HGS; HPN; HRAS; ITGA2; ITGA3; ITGB1; KRAS; LAMA1; LAMA2; LAMA3; LAMA4; LAMA5; LAMB1; LAMB2; LAMB3; LAMC1; LAMC2; LAMC3; LRIG1; MET; MUC20; NRAS; PIK3CA; PIK3R1; PTK2; PTPN1; PTPN2; PTPRJ; RAB4A; RAB4B; RAC1; RANBP10; RANBP9; RAP1A; RAP1B; RAPGEF1; SH3GL1; SH3GL2; SH3GL3; SHC1; SOS1; SPINT1; SPINT2; SRC; STAM; STAM2; STAT3; TNS3; UBA52; UBC; USP8"
"R-HSA-8875878","MET promotes cell motility",0.00911434755591468,0.262004181542775,0.972249562226063,28,"CRK; CRKL; DOCK7; GAB1; GRB2; HGF; ITGA2; ITGA3; ITGB1; LAMA1; LAMA2; LAMA3; LAMA4; LAMA5; LAMB1; LAMB2; LAMB3; LAMC1; LAMC2; LAMC3; MET; PTK2; RAC1; RAP1A; RAP1B; RAPGEF1; SRC; TNS3"
"R-HSA-9020956","Interleukin-27 signaling",-0.0151742625452298,0.438080771548458,0.972368362226148,10,"CANX; CRLF1; IL27; IL27RA; IL6ST; JAK1; JAK2; STAT1; STAT3; TYK2"
"R-HSA-3301854","Nuclear Pore Complex (NPC) Disassembly",-0.00848698559519477,0.249153959050297,0.972826739324655,31,"CCNB1; CCNB2; CDK1; NDC1; NEK6; NEK7; NEK9; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188; NUP205; NUP210; NUP214; NUP35; NUP43; NUP50; NUP54; NUP58; NUP62; NUP85; NUP88; NUP93; NUP98; NUPL2; POM121; RAE1; RANBP2; SEH1L"
"R-HSA-2151201","Transcriptional activation of mitochondrial biogenesis",-0.00684563834588706,0.206991468967624,0.973617107787748,45,"ACSS2; ALAS1; ATF2; ATP5B; CALM1; CAMK4; CARM1; CHD9; CRTC1; CRTC2; CRTC3; CYCS; ESRRA; GABPA; GABPB1; GLUD1; HDAC3; IDH2; MEF2C; MEF2D; NCOA1; NCOA2; NCOA6; NCOR1; NR1D1; NRF1; PERM1; POLG2; POLRMT; PPARA; PPARGC1A; PPARGC1B; PPRC1; RXRA; SIRT3; SIRT4; SIRT5; SMARCD3; SOD2; SSBP1; TBL1XR1; TFAM; TFB1M; TFB2M; TGS1"
"R-HSA-983695","Antigen activates B Cell Receptor (BCR) leading to generation of second messengers",-0.0124808638400913,0.384293109003367,0.974091291349417,13,"AHCYL1; BLK; BLNK; CALM1; CBL; CBLB; CD19; CD22; CD79A; CD79B; DAPP1; FYN; GRB2"
"R-HSA-1566948","Elastic fibre formation",-0.00733860826892963,0.228150206649207,0.974339919354479,37,"BMP4; BMP7; EFEMP1; EFEMP2; FBLN1; FBLN2; FBLN5; FBN1; FBN2; FBN3; FURIN; GDF5; ITGA5; ITGA8; ITGAV; ITGB1; ITGB3; ITGB5; ITGB6; ITGB8; LOX; LOXL1; LOXL2; LOXL3; LOXL4; LTBP1; LTBP2; LTBP3; LTBP4; MFAP1; MFAP2; MFAP3; MFAP4; TGFB1; TGFB2; TGFB3; VTN"
"R-HSA-376176","Signaling by ROBO receptors",0.00583500752868902,0.184010090729583,0.974703113966849,57,"ABL1; ABL2; ARHGAP39; CAP1; CAP2; CASC3; CDC42; CLASP1; CUL2; CXCL12; CXCR4; DAG1; DCC; EIF4A3; EIF4G1; ELOC; ENAH; ETF1; EVL; FAU; FLRT3; GPC1; GSPT1; HOXA2; LDB1; LHX2; LHX4; LHX9; MAGOH; MAGOHB; MSI1; MYO9B; NCBP1; NCBP2; NCK1; NCK2; NELL2; NRP1; NTN1; PABPC1; PAK1; PAK2; PAK4; PAK5; PAK6; PFN1; PFN2; PPP3CB; PRKACB; PRKAR2A; PRKCA; PSMA1; PSMA2; PSMA3; PSMA4; PSMA5; PSMA6"
"R-HSA-205043","NRIF signals cell death from the nucleus",-0.0126078394108388,0.399957614407805,0.974852498698018,12,"APH1A; APH1B; ITGB3BP; MAPK8; NCSTN; NGF; NGFR; PSEN1; PSEN2; TRAF6; UBA52; UBC"
"R-HSA-381038","XBP1(S) activates chaperone genes",0.00619821370595693,0.200371289693223,0.975322460462799,48,"ACADVL; ADD1; ARFGAP1; ATP6V0D1; CTDSP2; CUL7; CXXC1; DCTN1; DDX11; DNAJB11; DNAJB9; DNAJC3; EDEM1; EXTL1; EXTL2; EXTL3; FKBP14; GFPT1; GOSR2; HDGF; KDELR3; KLHDC3; LMNA; MYDGF; PDIA5; PDIA6; PLA2G4B; PPP2R5B; PREB; SEC61A1; SEC61A2; SEC61B; SEC61G; SEC62; SEC63; SERP1; SHC1; SRPRB; SSR1; SULT1A3; SYVN1; TATDN2; TLN1; TPP1; WFS1; WIPI1; XBP1; YIF1A"
"R-HSA-5696400","Dual Incision in GG-NER",0.00708057305673871,0.237878501264197,0.976254071811517,34,"CHD1L; CUL4A; DDB1; DDB2; ERCC3; ERCC4; ERCC5; GTF2H1; GTF2H2; GTF2H3; GTF2H4; GTF2H5; PARP1; PARP2; PCNA; POLD1; POLD2; POLD3; POLE; POLE2; POLE3; POLE4; POLK; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3; UBA52; UBC; XPA"
"R-HSA-389958","Cooperation of Prefoldin and TriC/CCT  in actin and tubulin folding",-0.00803243022893328,0.271959893475891,0.976437627213075,26,"CCT2; CCT3; CCT4; CCT5; CCT6A; CCT6B; CCT7; CCT8; PFDN1; PFDN5; PFDN6; TCP1; TUBA1A; TUBA1B; TUBA1C; TUBA3C; TUBA3E; TUBA4A; TUBA8; TUBAL3; TUBB1; TUBB2A; TUBB2B; TUBB3; TUBB4A; TUBB6"
"R-HSA-4570464","SUMOylation of RNA binding proteins",0.00641369325227489,0.219408394641064,0.976679752258482,40,"BMI1; CBX2; CBX4; CBX8; HNRNPK; NDC1; NOP58; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188; NUP205; NUP210; NUP214; NUP35; NUP43; NUP50; NUP54; NUP58; NUP62; NUP85; NUP88; NUP93; NUP98; NUPL2; PHC1; PHC2; PHC3; POM121; RAE1; RANBP2; RING1; RNF2; SCMH1; SEH1L; SUMO1; SUMO2; UBE2I"
"R-HSA-5653656","Vesicle-mediated transport",-0.00474571238665152,0.173786035828163,0.978214244512881,64,"AAK1; ACBD3; ACTR10; ACTR1A; ACTR2; ACTR3; ADRB2; AGFG1; AGPAT3; AGTR1; AKT1; AKT2; AKT3; ALB; ALS2; ALS2CL; AMBP; AMPH; ANK1; ANK2; ANK3; ANKRD27; ANKRD28; AP1B1; AP1G1; AP1G2; AP1M1; AP1M2; AP1S1; AP1S3; AP2A1; AP2A2; AP2B1; AP2M1; AP2S1; AP3B1; AP3S1; AP4B1; AP4E1; AP4M1; AP4S1; APOA1; APOB; APOL1; APP; ARCN1; AREG; ARF3; ARF4; ARF5; ARF6; ARFGAP1; ARFGAP2; ARFGAP3; ARFIP2; ARFRP1; ARL1; ARPC1A; ARPC2; ARPC3; ARPC4; ARPC5; ARRB1; ARRB2"
"R-HSA-168253","Host Interactions with Influenza Factors",-0.00580837230330472,0.231275226754842,0.979963597872967,36,"CPSF4; EIF2AK2; ISG15; KPNA1; KPNA2; KPNA3; KPNA4; KPNA5; KPNA7; KPNB1; NDC1; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188; NUP205; NUP210; NUP214; NUP35; NUP43; NUP50; NUP54; NUP58; NUP62; NUP85; NUP88; NUP93; NUP98; NUPL2; POM121; RAE1; RANBP2; SEH1L; TGFB1"
"R-HSA-2243919","Crosslinking of collagen fibrils",0.0108533092653161,0.437848323166712,0.980224199305228,10,"BMP1; LOX; LOXL1; LOXL2; LOXL3; LOXL4; PCOLCE; PXDN; TLL1; TLL2"
"R-HSA-8955332","Carboxyterminal post-translational modifications of tubulin",0.00537440367567849,0.245176557380165,0.982511336442908,32,"AGBL2; AGBL3; AGBL4; AGBL5; AGTPBP1; NICN1; TPGS1; TPGS2; TTL; TTLL1; TTLL10; TTLL11; TTLL12; TTLL13P; TTLL2; TTLL3; TTLL4; TTLL5; TTLL6; TTLL7; TTLL9; TUBA1A; TUBA1B; TUBA1C; TUBA3C; TUBA3E; TUBB1; TUBB2A; TUBB2B; TUBB3; TUBB4A; TUBB6"
"R-HSA-5625740","RHO GTPases activate PKNs",-0.00457871417718796,0.211712753511217,0.982745486423063,43,"H2AFJ; H2AFV; H2AFX; H2AFZ; H2BFS; H3F3A; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HIST2H2AA3; HIST2H2AC; KDM1A; KDM4C; KLK2; KLK3; MYH10; MYH11; MYH14; MYH9; MYL12B; MYL6; MYL9; NCOA2; PAK1; PDPK1; PKN1; PKN2; PKN3; PPP1CB; PPP1R12A; PPP1R12B; PPP1R14A; RAC1; RHOB; RHOC; SFN; YWHAB; YWHAE; YWHAG; YWHAH; YWHAQ; YWHAZ"
"R-HSA-8963743","Digestion and absorption",-0.00757411291307644,0.357781886629754,0.983110334463662,15,"AMY2A; AMY2B; CEL; CHIA; CHIT1; CLPS; GUCA2A; GUCY2C; LCT; MGAM; NPC1L1; PNLIPRP3; SLC2A5; SLC5A1; TREH"
"R-HSA-74182","Ketone body metabolism",-0.00907607385036123,0.438047005691157,0.983469488424826,10,"AACS; ACAT1; ACSS3; BDH1; BDH2; HMGCL; HMGCLL1; HMGCS2; OXCT1; OXCT2"
"R-HSA-163560","Triglyceride catabolism",0.00732019449561449,0.357664931984074,0.983671134869231,15,"CAV1; FABP1; FABP2; FABP3; FABP4; FABP6; FABP7; GPD2; LIPE; MGLL; PLIN1; PLIN3; PNPLA5; PPP1CB; PRKACB"
"R-HSA-162909","Host Interactions of HIV factors",-0.00359191592950954,0.177965553458809,0.983897222573114,61,"AP1B1; AP1G1; AP1M1; AP1M2; AP1S1; AP1S3; AP2A1; AP2A2; AP2B1; AP2M1; AP2S1; APOBEC3G; ATP6V1H; B2M; BANF1; BTRC; CCNT1; CD247; CD28; CD4; CD8B; CDK9; CUL5; DOCK2; ELMO1; ELOC; FYN; HCK; HLA-A; HMGA1; KPNA1; KPNB1; NDC1; NPM1; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188; NUP205; NUP210; NUP214; NUP35; NUP43; NUP50; NUP54; NUP58; NUP62; NUP85; NUP88; NUP93; NUP98; NUPL2; PACS1; PAK2; POM121; PPIA; PSIP1; PSMA1; PSMA2"
"R-HSA-1221632","Meiotic synapsis",-0.00443260335453844,0.225132374125279,0.984291564880302,38,"ACD; ATR; BRCA1; DIDO1; H2AFJ; H2AFV; H2AFX; H2AFZ; H2BFS; HIST1H2BD; HIST1H2BJ; HIST1H2BK; HIST1H2BN; HIST2H2AA3; HIST2H2AC; HSPA2; LMNA; LMNB1; POT1; RAD21; REC8; SMC3; STAG1; STAG3; SUN1; SUN2; SYCE1; SYCE2; SYCE3; SYCP2; SYCP3; SYNE1; SYNE2; TERF1; TERF2; TERF2IP; TEX12; UBE2I"
"R-HSA-111465","Apoptotic cleavage of cellular proteins",-0.00471474305494114,0.245231467861758,0.984661067389652,32,"ADD1; APC; BIRC2; CASP3; CASP6; CASP7; CASP8; CDH1; CTNNB1; DBNL; DSG1; DSG2; DSG3; DSP; FNTA; GAS2; GSN; LMNA; LMNB1; MAPT; OCLN; PKP1; PLEC; PRKCD; PRKCQ; PTK2; ROCK1; SATB1; STK24; TJP1; TJP2; VIM"
"R-HSA-918233","TRAF3-dependent IRF activation pathway",0.00800210443177147,0.417537831890876,0.98470949393267,11,"DDX58; EP300; IFIH1; IRF3; IRF7; MAVS; RNF135; SIKE1; TBK1; TRAF3; TRIM25"
"R-HSA-418457","cGMP effects",-0.00558256573433536,0.326613729848993,0.986363016215904,18,"ITPR1; KCNMA1; KCNMB1; KCNMB2; KCNMB3; KCNMB4; MRVI1; PDE10A; PDE11A; PDE1A; PDE1B; PDE2A; PDE3A; PDE3B; PDE5A; PDE9A; PRKG1; PRKG2"
"R-HSA-9006934","Signaling by Receptor Tyrosine Kinases",-0.0027217949347138,0.177962542198858,0.987797468678479,61,"ABI1; ABR; ADAM10; ADAM12; ADAM17; ADCYAP1; ADCYAP1R1; ADORA2A; AHCYL1; AKAP13; AKT1; AKT2; AKT3; AP2A1; AP2A2; AP2B1; AP2M1; AP2S1; APH1A; APH1B; ARF6; ARHGDIA; ARHGEF10; ARHGEF10L; ARHGEF11; ARHGEF12; ARHGEF15; ARHGEF16; ARHGEF17; ARHGEF18; ARHGEF19; ARHGEF2; ARHGEF26; ARHGEF3; ARHGEF33; ARHGEF35; ARHGEF37; ARHGEF38; ARHGEF39; ARHGEF4; ARHGEF40; ARHGEF5; ARHGEF7; ATF1; ATP6V0A1; ATP6V0A2; ATP6V0A4; ATP6V0B; ATP6V0C; ATP6V0D1; ATP6V0D2; ATP6V0E1; ATP6V0E2; ATP6V1A; ATP6V1B1; ATP6V1B2; ATP6V1C1; ATP6V1C2; ATP6V1D; ATP6V1E1; ATP6V1E2"
"R-HSA-77286","mitochondrial fatty acid beta-oxidation of saturated fatty acids",-0.00543574536247094,0.417667277973962,0.989616196675921,11,"ACADL; ACADM; ACADS; ACADVL; ACSM3; ACSM6; ECHS1; HADH; HADHA; HADHB; MECR"
"R-HSA-202040","G-protein activation",-0.0030168692713545,0.277300708709719,0.991319654606618,25,"GNAI1; GNAI2; GNAI3; GNAO1; GNAT1; GNAT2; GNAT3; GNAZ; GNB1; GNB2; GNB3; GNB4; GNB5; GNG10; GNG11; GNG12; GNG2; GNG3; GNG4; GNG5; GNG7; GNGT2; OPRM1; PDYN; POMC"
"R-HSA-5683826","Surfactant metabolism",-0.00238076441131737,0.28299403872065,0.993287658042073,24,"ABCA3; ADGRF5; ADORA2A; ADORA2B; ADRA2A; ADRA2C; CKAP4; CSF2RB; CTSH; DMBT1; LMCD1; NAPSA; P2RY2; PGA3; PGA5; SFTPA1; SFTPA2; SFTPB; SFTPC; SFTPD; SLC34A1; SLC34A2; TTF1; ZDHHC2"
"R-HSA-5654704","SHC-mediated cascade:FGFR3",0.00280598691259341,0.370236147309223,0.993952961593362,14,"FGF1; FGF17; FGF18; FGF2; FGF20; FGF5; FGF9; FGFR3; GRB2; HRAS; KRAS; NRAS; SHC1; SOS1"
"R-HSA-73817","Purine ribonucleoside monophosphate biosynthesis",-0.0029921146436032,0.417648087197519,0.994283843912082,11,"ADSL; ADSS; ADSSL1; ATIC; GMPS; IMPDH1; IMPDH2; LHPP; PAICS; PFAS; PPAT"
"R-HSA-354194","GRB2:SOS provides linkage to MAPK signaling for Integrins ",0.00251578395568526,0.357709346088822,0.994388492639283,15,"APBB1IP; FGA; FGB; FGG; FN1; GRB2; ITGA2B; ITGB3; PTK2; RAP1A; RAP1B; SOS1; SRC; TLN1; VWF"
"R-HSA-8856828","Clathrin-mediated endocytosis",0.000990650476411053,0.176520576056162,0.995522218492562,62,"AAK1; ACTR2; ACTR3; ADRB2; AGFG1; AGTR1; AMPH; AP2A1; AP2A2; AP2B1; AP2M1; AP2S1; APOB; ARF6; ARFGAP1; ARPC1A; ARPC2; ARPC3; ARPC4; ARPC5; ARRB1; ARRB2; BIN1; CBL; CD3D; CD4; CFTR; CHRM2; CLTA; CLTB; CLTC; CLTCL1; COPS2; COPS3; COPS6; COPS7A; COPS7B; COPS8; CTTN; DAB2; DNAJC6; DNM1; DNM2; DNM3; DVL2; EGF; EGFR; EPN1; EPN2; EPS15; EPS15L1; FCHO1; FCHO2; FNBP1; FNBP1L; FZD4; GAK; GAPVD1; GPS1; GRB2; GRK3; HGS"
"R-HSA-204174","Regulation of pyruvate dehydrogenase (PDH) complex",0.00228783915570781,0.417600014955256,0.995628777914122,11,"DLAT; DLD; PDHB; PDHX; PDK1; PDK2; PDK4; PDP1; PDPR; PPARD; RXRA"
"R-HSA-917977","Transferrin endocytosis and recycling",-0.00115598672420518,0.262071447301687,0.996480574368936,28,"ATP6V0A1; ATP6V0A2; ATP6V0A4; ATP6V0B; ATP6V0C; ATP6V0D1; ATP6V0D2; ATP6V0E1; ATP6V0E2; ATP6V1A; ATP6V1B1; ATP6V1B2; ATP6V1C1; ATP6V1C2; ATP6V1D; ATP6V1E1; ATP6V1E2; ATP6V1F; ATP6V1G1; ATP6V1G2; ATP6V1H; HFE; STEAP2; STEAP3; TCIRG1; TF; TFR2; TFRC"
"R-HSA-159234","Transport of Mature mRNAs Derived from Intronless Transcripts",0.000866468556058454,0.231244263840899,0.997010346314787,36,"ALYREF; CPSF1; CPSF2; CPSF3; CPSF4; EIF4E; FIP1L1; NCBP1; NCBP2; NDC1; NUP107; NUP133; NUP153; NUP155; NUP160; NUP188; NUP205; NUP210; NUP214; NUP35; NUP43; NUP50; NUP54; NUP58; NUP62; NUP85; NUP88; NUP93; NUP98; NUPL2; NXF1; POM121; RAE1; RANBP2; SEH1L; SLBP"
"R-HSA-379726","Mitochondrial tRNA aminoacylation",-0.000664570549616765,0.302449084515987,0.998246811838537,21,"AARS2; CARS2; DARS2; EARS2; FARS2; GARS; HARS2; IARS2; KARS; LARS2; MARS2; NARS2; PARS2; PPA2; QARS; RARS2; SARS2; TARS2; VARS2; WARS2; YARS2"
"R-HSA-399955","SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion",0.000420922846354068,0.39986726545993,0.999160101845336,12,"FARP2; FES; FYN; NRP1; PIP5K1C; PLXNA1; PLXNA2; PLXNA4; RAC1; RRAS; SEMA3A; TLN1"
"R-HSA-8949613","Cristae formation",-0.000268043272799269,0.282981497202431,0.999244234838224,24,"ATP5A1; ATP5B; ATP5C1; ATP5D; ATP5E; ATP5F1; ATP5G1; ATP5G2; ATP5G3; ATP5H; ATP5I; ATP5J2; ATP5L; ATP5O; ATP5S; CHCHD3; CHCHD6; DNAJC11; IMMT; MINOS1; MTX1; MTX2; SAMM50; TMEM11"
"R-HSA-5655862","Translesion synthesis by POLK",-1.08179001550611e-05,0.357730150525045,0.999975871657728,15,"MAD2L2; PCNA; POLK; REV1; REV3L; RFC1; RFC2; RFC3; RFC4; RFC5; RPA1; RPA2; RPA3; UBA52; UBC"