{"text_format":"2","workbook":"xlsx","n_sheets":2,"sheets":["reaction name","reaction ID"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":0,"defined_names":0,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900"}

{"sheet":"reaction name","index":0,"n_rows":414,"n_cols":3,"rows_kept":414,"cut":false,"hidden":false,"merged":[]}
["* Generated utilizing RIPTiDe with E.coli transcriptome growing in aerobic LB rich media"]
[]
["No_GPR","GPR","Both"]
["Phosphatidylglycerophosphate transport via ABC system (n-C18:1, periplasm)","Cu+ exchange","Nicotinamide-nucleotide adenylyltransferase"]
["Phosphatidylglycerol phosphate phosphatase (periplasm, n-C18:1)","D-lactate transport via diffusion (extracellular to periplasm)","NMN permease (periplasm)"]
["Uridine transport via diffusion (extracellular to periplasm)","Pyruvate exchange","Octadecenoate (n-C18:1) transport via facilitated irreversible diffusion (extracellular to periplasm)"]
["Pyruvate formate lyase","Pyruvate dehydrogenase","L-alanine transport via diffusion (extracellular to periplasm)"]
["Alanyl aminopeptidase (cys-gly)","Pyruvate reversible transport via proton symport (periplasm)","Magnesium (+2) transport in via diffusion"]
["Cu2+ exchange","L-cysteine transport via diffusion (extracellular to periplasm)","Adenosylcobalamin transport via ABC system (periplasm)"]
["Nitrate transport via diffusion (extracellular to periplasm)","Pyruvate transport via diffusion (extracellular to periplasm)","Glutamine synthetase"]
["Nitrate exchange","Phosphatidylglycerol transport via ABC system (n-C16:0, periplasm)","Cardiolipin synthase (periplasmic, n-C16:1)"]
["Glycerophosphodiester phosphodiesterase (Glycerophosphoserine)","L-Serine exchange","Acetate exchange"]
["Nitrite Reductase (Ubiquinole-8, periplasm)","Thymidine exchange","S-methylmethionine permease (periplasm)"]
["Glycerophosphoserine exchange","Phosphatidylglycerol transport via ABC system (n-C18:1, periplasm)","L-isoleucine transport via diffusion (extracellular to periplasm)"]
["Nitrate transport in via nitrite antiport (periplasm)","Nucleoside-diphosphate kinase (ATP:dADP)","L-Histidine exchange"]
["Phosphatidylglycerol phosphate phosphatase (periplasm, n-C16:0)","NAD(P) transhydrogenase (periplasm)","Nucleoside-diphosphate kinase (ATP:dCDP)"]
["Murein D,D-carboxypeptidase (murein5p3p) (periplasm)","L-serine transport via diffusion (extracellular to periplasm)","Alanine racemase"]
["Deoxyuridine transport via diffusion (extracellular to periplasm)","Murein L,D-carboxypeptidase (murein5px3p) (periplasm)","Geranyltranstransferase"]
["Deoxyuridine exchange","Cytidine deaminase","Sirohydrochlorin dehydrogenase (NAD)"]
["Flavodoxin reductase (NADPH)","L-Cysteine exchange","L-Proline exchange"]
["Formate Dehydrogenase (menaquinone-8) (periplasm)","Ribonucleoside-diphosphate reductase (ADP)","5,10-methylenetetrahydrofolate reductase (NADH)"]
["Ribonucleoside-triphosphate reductase (ATP) (flavodoxin)","Cuprous Oxidase (Cu+1)","Phosphatidylserine syntase (n-C16:1)"]
["Uridine exchange","Murein crosslinking transpeptidase 1B:(A2pm->A2pm) (periplasm)","Sodium proton antiporter (H:NA is 1.5) (periplasm)"]
["Deoxyuridine kinase (ATP:Deoxyuridine)","D-lactate exchange","Homocysteine Methyltransferase"]
["Murein L,D-carboxypeptidase (murein4p3p) (periplasm)","Murein L,D-endopeptidase (murein3px3p) (periplasm)","O-succinylbenzoate-CoA synthase"]
["L-arginine transport via ABC system (periplasm)","D-lactate transport via proton symport (periplasm)","Thiamine transport via diffusion (extracellular to periplasm)"]
["L-Cysteinylglycine (Cys-Gly) transport via ABC system (periplasm)","Putrescine/ornithine antiporter (periplasm)","Calcium (Ca+2) transport via diffusion (extracellular to periplasm)"]
["Murein L,D-carboxypeptidase (murein5p5p) (periplasm)","Phosphatidylglycerol transport via ABC system (n-C16:1, periplasm)","CDP-diacylglycerol synthetase (n-C16:0)"]
["Glycerophosphserine transport via diffusion (extracellular to periplasm)","L-cysteine uptake via ABC system (periplasm)","ISC [2Fe-2S] Synthesis"]
["Deoxyuridine transport in via proton symport (periplasm)","Thymidine kinase (ATP:thymidine)","O2 exchange"]
["L-Cysteinylglycine transport via diffusion (extracellular to periplasm)","Arginine/ornithine antiporter (periplasm)","L-Methionine exchange"]
["Phosphatidylglycerophosphate transport via ABC system (n-C16:1, periplasm)","D-lactate dehydrogenase","Nickel transport via diffusion (extracellular to periplasm)"]
["Ammonia exchange","Nitrite exchange","Fatty-acid-CoA thioesterase (octadecenoate)"]
["Phosphatidylglycerol phosphate phosphatase (periplasm, n-C16:1)","Copper (Cu+1) transport via diffusion (extracellular to periplasm)","Succinate transport via diffusion (extracellular to periplasm)"]
["Cys-Gly exchange","Thymidine transport via diffusion (extracellular to periplasm)","Uroporphyrinogen decarboxylase (uroporphyrinogen III)"]
["Phosphatidylglycerophosphate transport via ABC system (n-C16:0, periplasm)","Nitrite transport via diffusion (extracellular to periplasm)","Chloride (Cl-1) transport via diffusion (extracellular to periplasm)"]
["Copper (Cu+2) transport via diffusion (extracellular to periplasm)",null,"Phosphate reversible transport via symport (periplasm)"]
["Nitrate reductase (Menaquinol-8) (periplasm)","* Ex. While the majority of model architecture was consistent between both approaches, pyruvate was primarily imported in the GPR-associated model and was correctly synthesized intracellularly [65] when GPR rules were not considered.","L-Phenylalanine exchange"]
["Thymidylate synthase",null,"L-alanine-D-glutamate-meso-2,6-diaminoheptanedioate exchange"]
["Ammonia transport via diffusion (extracellular to periplasm)",null,"1,4-dihydroxy-2-napthoyl-CoA thioesterase"]
["NADH dehydrogenase (menaquinone-8 & 3 protons) (periplasm)",null,"Pyruvate synthase"]
["Asparagine synthetase",null,"L-serine reversible transport via proton symport (periplasm)"]
[null,null,"D-alanine-D-alanine ligase (reversible)"]
[null,null,"Glycerol-3-phosphate : phosphate antiporter (periplasm)"]
[null,null,"Iron (II) transport via diffusion (extracellular to periplasm)"]
[null,null,"Dihydroneopterin monophosphate dephosphorylase"]
[null,null,"UDP-N-acetylglucosamine 1-carboxyvinyltransferase"]
[null,null,"Mn2+ exchange"]
[null,null,"2-oxoglutarate reversible transport via symport (periplasm)"]
[null,null,"Lipoate transport via diffusion (extracellular to periplasm)"]
[null,null,"Chorismate synthase"]
[null,null,"Guanylate kinase (GMP:ATP)"]
[null,null,"2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase"]
[null,null,"GTP cyclohydrolase II (25drapp)"]
[null,null,"Hexadecanoate transport via facilitated irreversible diffusion (extracellular to periplasm)"]
[null,null,"Adenosine exchange"]
[null,null,"Methionine adenosyltransferase"]
[null,null,"Uridine kinase (GTP:Uridine)"]
[null,null,"Manganese transport in via permease (no H+)"]
[null,null,"Dihydrofolate synthase"]
[null,null,"Cytidine exchange"]
[null,null,"Core oligosaccharide lipid A exchange"]
[null,null,"Threonine aldolase"]
[null,null,"Spermidine transport via diffusion (extracellular to periplasm)"]
[null,null,"Iron-sulfur cluster repair"]
[null,null,"O2 transport via diffusion (periplasm)"]
[null,null,"Glycolaldehyde dehydrogenase"]
[null,null,"Fe-enterobactin exchange"]
[null,null,"L-Tyrosine exchange"]
[null,null,"Octadecenoate (n-C18:1) exchange"]
[null,null,"2C-methyl-D-erythritol 2,4 cyclodiphosphate dehydratase"]
[null,null,"Phosphatidylethanolamine transport via ABC system (n-C16:1, periplasm)"]
[null,null,"1,4-dihydroxy-2-naphthoate octaprenyltransferase"]
[null,null,"Biotin transport via proton symport (periplasm)"]
[null,null,"S-Methyl-L-methionine exchange"]
[null,null,"Molybdopterin guanine dinucleotide synthase"]
[null,null,"Dimethylallyltranstransferase"]
[null,null,"Triose-phosphate isomerase"]
[null,null,"2-octaprenyl-6-methoxyphenol hydroxylase"]
[null,null,"Phosphate transport via diffusion (extracellular to periplasm)"]
[null,null,"Co2+ exchange"]
[null,null,"Thiamin exchange"]
[null,null,"L-phenylalanine transport via diffusion (extracellular to periplasm)"]
[null,null,"L-Asparagine exchange"]
[null,null,"Phosphoglucomutase"]
[null,null,"ISC [4Fe-4S] Reduction"]
[null,null,"2-Octaprenyl-6-methoxy-benzoquinol methylase"]
[null,null,"UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase"]
[null,null,"Adenosylcobalimin transport via ton system (extermal)"]
[null,null,"Molybdate exchange"]
[null,null,"Dephospho-CoA kinase"]
[null,null,"Pyridoxal exchange"]
[null,null,"Deoxyadenosine transport via diffusion (extracellular to periplasm)"]
[null,null,"Purine-nucleoside phosphorylase (Deoxyadenosine)"]
[null,null,"Uroporphyrinogen methyltransferase"]
[null,null,"6-hydroxymethyl-dihydropterin pyrophosphokinase"]
[null,null,"LalaDgluMdap (tripeptide) transport via diffusion (extracellular to periplasm)"]
[null,null,"Diaminohydroxyphosphoribosylaminopryrimidine deaminase (25drapp)"]
[null,null,"Sulfate transport in via proton symport (periplasm to cytoplasm)"]
[null,null,"1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (ipdp)"]
[null,null,"Dihydrofolate reductase"]
[null,null,"Oxygen transport via diffusion (extracellular to periplasm)"]
[null,null,"Phosphatidylglycerol phosphate phosphatase (n-C16:1)"]
[null,null,"Deoxyadenosine transport in via proton symport (periplasm)"]
[null,null,"Sulfate exchange"]
[null,null,"Spermidine transport via ABC system (periplasm)"]
[null,null,"Deoxyadenosine exchange"]
[null,null,"Adenine transport via proton symport (reversible) (periplasm)"]
[null,null,"Chloride exchange"]
[null,null,"Reduced glutathione via ABC system (periplasm)"]
[null,null,"Cobalt transport in via permease (no H+)"]
[null,null,"Pyridoxal kinase"]
[null,null,"Formate transport via diffusion (cytoplasm to periplasm)"]
[null,null,"Sink needed to allow (2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran to leave system"]
[null,null,"Acetate transport via diffusion (extracellular to periplasm)"]
[null,null,"CDP-diacylglycerol synthetase (n-C16:1)"]
[null,null,"ISC Cysteine desulfuration"]
[null,null,"Riboflavin synthase"]
[null,null,"L-Arginine exchange"]
[null,null,"Zinc exchange"]
[null,null,"Glycerol transport via diffusion (extracellular to periplasm)"]
[null,null,"(2R,4S)-2-methyl-2,3,3,4-tetrahydroxytetrahydrofuran synthesis (spontaneous)"]
[null,null,"Ribonucleoside-diphosphate reductase (GDP)"]
[null,null,"Phosphoglucosamine mutase"]
[null,null,"Dihydroneopterin triphosphate pyrophosphatase"]
[null,null,"Molybdopterin synthase sulfurylase"]
[null,null,"Transaldolase"]
[null,null,"Glutamyl-tRNA synthetase"]
[null,null,"Octaprenyl pyrophosphate synthase"]
[null,null,"HCO3 equilibration reaction"]
[null,null,"Adenylate kinase"]
[null,null,"2-Octaprenylphenol hydroxylase"]
[null,null,"S-ribosylhomocysteine cleavage enzyme"]
[null,null,"Pyruvate kinase"]
[null,null,"S-adenosylmethione:2-demthylmenaquinole methyltransferase (menaquinone 8)"]
[null,null,"Nucleoside-diphosphate kinase (ATP:dTDP)"]
[null,null,"Iron-sulfur cluster damage (peroxide, spontaneous)"]
[null,null,"Hexadecenoate (n-C16:1) exchange"]
[null,null,"Phosphotransacetylase"]
[null,null,"(R)-Pantothenate exchange"]
[null,null,"Proton transport via diffusion (extracellular to periplasm)"]
[null,null,"Glycolate transport via proton symport, reversible (periplasm)"]
[null,null,"Riboflavin synthase"]
[null,null,"L-Threonine exchange"]
[null,null,"Indole transport via proton symport, reversible (periplasm)"]
[null,null,"Glycerol exchange"]
[null,null,"Hexadecenoate transport via facilitated irreversible diffusion (extracellular to periplasm)"]
[null,null,"Flavin reductase (NAD)"]
[null,null,"L-alanine transaminase"]
[null,null,"Phosphate exchange"]
[null,null,"Reduced glutathione exchange"]
[null,null,"NADH dehydrogenase (ubiquinone-8 & 3 protons) (periplasm)"]
[null,null,"L-asparagine transport via diffusion (extracellular to periplasm)"]
[null,null,"Magnesium (Mg+2) transport via diffusion (extracellular to periplasm)"]
[null,null,"CO2 exchange"]
[null,null,"Transketolase"]
[null,null,"Acyl-[acyl-carrier-protein] synthetase  (n-C18:1)"]
[null,null,"Phosphatidylserine syntase (n-C18:1)"]
[null,null,"3,4-Dihydroxy-2-butanone-4-phosphate synthase"]
[null,null,"Deoxyribose-phosphate aldolase"]
[null,null,"Murein crosslinking transpeptidase 1A:(A2pm->D-ala) (periplasm)"]
[null,null,"Phosphopantothenate-cysteine ligase"]
[null,null,"Uroporphyrinogen-III synthase"]
[null,null,"L-Isoleucine exchange"]
[null,null,"Acetate kinase"]
[null,null,"Acetaldehyde dehydrogenase (acetylating)"]
[null,null,"D-Alanine transport via diffusion (extracellular to periplasm)"]
[null,null,"Glucose-6-phosphate isomerase"]
[null,null,"Phosphatidylserine syntase (n-C16:0)"]
[null,null,"UDP-N-acetylglucosamine diphosphorylase"]
[null,null,"L-histidine transport via diffusion (extracellular to periplasm)"]
[null,null,"Porphobilinogen synthase"]
[null,null,"L-isoleucine reversible transport via proton symport (periplasm)"]
[null,null,"L-Alanine exchange"]
[null,null,"Murein D,D-carboxypeptidase (murein5px4p) (periplasm)"]
[null,null,"D-glucosamine 6-phosphate transport via diffusion (extracellular to periplasm)"]
[null,null,"Glycerol-3-phosphate acyltransferase (C18:1)"]
[null,null,"CO2 transporter via diffusion (periplasm)"]
[null,null,"L-valine reversible transport via proton symport (periplasm)"]
[null,null,"Spermidine exchange"]
[null,null,"Murein D,D-carboxypeptidase (murein5p5p) (periplasm)"]
[null,null,"Lipoyl-adenylate protein ligase"]
[null,null,"Lipoate transport via proton symport (periplasm)"]
[null,null,"Copper transport in via permease (no H+)"]
[null,null,"Thiamine transport via ABC system (periplasm)"]
[null,null,"D-Alanyl-D-alanine exchange"]
[null,null,"Potassium transport in via proton symport (periplasm)"]
[null,null,"Methenyltetrahydrofolate cyclohydrolase"]
[null,null,"Acyl-[acyl-carrier-protein] synthetase  (n-C16:0)"]
[null,null,"Ribonucleoside-diphosphate reductase (CDP)"]
[null,null,"H2O transport via diffusion (extracellular to periplasm)"]
[null,null,"Hydroxymethylbilane synthase"]
[null,null,"UDP-N-acetylenolpyruvoylglucosamine reductase"]
[null,null,"Glutamate dehydrogenase (NADP)"]
[null,null,"Phosphatidylethanolamine transport via ABC system (n-C16:0, periplasm)"]
[null,null,"L-leucine transport via diffusion (extracellular to periplasm)"]
[null,null,"GTP cyclohydrolase I"]
[null,null,"Ribose-5-phosphate isomerase"]
[null,null,"Succinate dehydrogenase (irreversible)"]
[null,null,"L-histidine reversible transport via proton symport (periplasm)"]
[null,null,"ATP maintenance requirement"]
[null,null,"Malate dehydrogenase"]
[null,null,"Fe-enterobactin reduction (Fe(III)-unloading)"]
[null,null,"Shikimate transport in via proton symport (periplasm)"]
[null,null,"Hexadecanoate (n-C16:0) exchange"]
[null,null,"L-threonine transport via diffusion (extracellular to periplasm)"]
[null,null,"H2O exchange"]
[null,null,"Glyceraldehyde-3-phosphate dehydrogenase"]
[null,null,"Putrescine exchange"]
[null,null,"L-valine transport via diffusion (extracellular to periplasm)"]
[null,null,"Pyrimidine phosphatase"]
[null,null,"Phosphatidylglycerol synthase (n-C18:1)"]
[null,null,"Phosphopentomutase 2 (deoxyribose)"]
[null,null,"Molybdopterin synthase"]
[null,null,"NMN transport via diffusion (extracellular to periplasm)"]
[null,null,"Mg exchange"]
[null,null,"Molybdate transport via ABC system (periplasm)"]
[null,null,"Succinyl-CoA synthetase (ADP-forming)"]
[null,null,"1-deoxy-D-xylulose 5-phosphate synthase"]
[null,null,"CO2 transport via diffusion (extracellular to periplasm)"]
[null,null,"Murein D,D-carboxypeptidase (murein5px4px4p) (periplasm)"]
[null,null,"Molybdenum cofactor synthase"]
[null,null,"Zinc transport in via permease (no H+)"]
[null,null,"Dihydropteroate synthase"]
[null,null,"L-proline transport via diffusion (extracellular to periplasm)"]
[null,null,"NAD kinase"]
[null,null,"S-adenosylhomocysteine nucleosidase"]
[null,null,"Adenosine transport via diffusion (extracellular to periplasm)"]
[null,null,"Calcium exchange"]
[null,null,"Phosphoglycerate kinase"]
[null,null,"Pyridoxal transport via diffusion (extracellular)"]
[null,null,"Guanosine kinase"]
[null,null,"Thioredoxin reductase (NADPH)"]
[null,null,"L-asparagine reversible transport via proton symport (periplasm)"]
[null,null,"2-octaprenyl-6-hydroxyphenol methylase"]
[null,null,"L-lysine transport via diffusion (extracellular to periplasm)"]
[null,null,"Methylenetetrahydrofolate dehydrogenase (NADP)"]
[null,null,"Adenosine kinase"]
[null,null,"2-Octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase"]
[null,null,"L-Valine exchange"]
[null,null,"Nitrite transport in via proton symport, reversible (periplasm)"]
[null,null,"Enolase"]
[null,null,"DTMP kinase"]
[null,null,"Ribulose 5-phosphate 3-epimerase"]
[null,null,"Lipoate-ATP adenylate transferase"]
[null,null,"FMN adenylyltransferase"]
[null,null,"ATP synthase (four protons for one ATP) (periplasm)"]
[null,null,"Bis-molybdopterin guanine dinucleotide synthase (single GDP)"]
[null,null,"Glutamyl-tRNA reductase"]
[null,null,"Phosphatidylglycerol phosphate phosphatase (n-C16:0)"]
[null,null,"Zinc (Zn+2) transport via diffusion (extracellular to periplasm)"]
[null,null,"O-succinylbenzoate-CoA ligase"]
[null,null,"1-hexadecanoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C16:0)"]
[null,null,"1-deoxy-D-xylulose reductoisomerase"]
[null,null,"1-hexadec-7-enoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C16:1)"]
[null,null,"ISC [2Fe-2S] Transfer"]
[null,null,"4-aminobenzoate synthase"]
[null,null,"UDP-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase"]
[null,null,"UMP kinase"]
[null,null,"Fatty-acid-CoA ligase (octadecenoate transport via vectoral Co-A coupling)"]
[null,null,"Phosphatidylserine decarboxylase (n-C18:1)"]
[null,null,"Undecaprenyl-diphosphatase"]
[null,null,"Cobalt (Co+2) transport via diffusion (extracellular to periplasm)"]
[null,null,"D-Alanine exchange"]
[null,null,"Glycine hydroxymethyltransferase, reversible"]
[null,null,"Succinate transport out via proton antiport (periplasm)"]
[null,null,"2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase"]
[null,null,"L-lysine transport in via proton symport (periplasm)"]
[null,null,"L-tyrosine reversible transport via proton symport (periplasm)"]
[null,null,"Nucleoside-diphosphate kinase (ATP:CDP)"]
[null,null,"L-Lysine exchange"]
[null,null,"Tryptophanase (L-tryptophan)"]
[null,null,"Fumarase"]
[null,null,"Cyclic pyranopterin monophosphate synthase"]
[null,null,"Riboflavin kinase"]
[null,null,"4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase"]
[null,null,"Indole exchange"]
[null,null,"L-proline reversible transport via proton symport (periplasm)"]
[null,null,"Fe2+ exchange"]
[null,null,"Alpha-ketoglutarate transport via diffusion (extracellular to periplasm)"]
[null,null,"Polyphosphate kinase"]
[null,null,"Cytidylate kinase (CMP)"]
[null,null,"D-alanyl-D-alanine (DalaDala) transport via diffusion (extracellular to periplasm)"]
[null,null,"Murein polymerizing transglycosylase"]
[null,null,"Malate oxidase"]
[null,null,"S-methyl-L-methionine transport via diffusion (extracellular to periplasm)"]
[null,null,"L-phenylalanine reversible transport via proton symport (periplasm)"]
[null,null,"L-methionine transport via diffusion (extracellular to periplasm)"]
[null,null,"Phosphopentomutase"]
[null,null,"Glycerol-3-phosphate acyltransferase (C16:1)"]
[null,null,"Cardiolipin synthase (periplasmic, n-C18:1)"]
[null,null,"Nitrite Reductase (NADH)"]
[null,null,"Putrescine transport in via proton symport"]
[null,null,"Calcium / sodium antiporter (1:1)"]
[null,null,"Sirohydrochlorin ferrochelatase"]
[null,null,"Fe-enterobactin transport via ton system (extracellular)"]
[null,null,"Glycerol-3-phosphate transport via diffusion (extracellular to periplasm)"]
[null,null,"4,5-dihydroxy-2,3-pentanedione cyclization (spontaneous)"]
[null,null,"ISC [4Fe-4S] Transfer"]
[null,null,"Acetyl-CoA carboxylase"]
[null,null,"Molybdate transport via diffusion (extracellular to periplasm)"]
[null,null,"Purine-nucleoside phosphorylase (Adenosine)"]
[null,null,"ISC [2Fe-2S] Synthesis II"]
[null,null,"Fatty-acid-CoA ligase (hexadecenoate transport via vectoral Co-A coupling)"]
[null,null,"Octaprenyl-hydroxybenzoate decarboxylase"]
[null,null,"Chloride transport out via proton antiport (2:1) (periplasm)"]
[null,null,"Glycolate exchange"]
[null,null,"Adenosylcobalamin exchange"]
[null,null,"Nickel (+2) transport in via permease (no H+)"]
[null,null,"Ni2+ exchange"]
[null,null,"L-methionine transport via ABC system (periplasm)"]
[null,null,"Bis-molybdenum cofactor synthase"]
[null,null,"Thiamine kinase"]
[null,null,"Potassium transport via diffusion (extracellular to periplasm)"]
[null,null,"MoaD sulfuration (nadh, assumed)"]
[null,null,"Phosphopantothenoylcysteine decarboxylase"]
[null,null,"Cytidine kinase (GTP)"]
[null,null,"L-threonine  via sodium symport (periplasm)"]
[null,null,"L-arginine transport via diffusion (extracellular to periplasm)"]
[null,null,"Glutamate-1-semialdehyde aminotransferase"]
[null,null,"Fatty-acid-CoA ligase (hexadecanoate transport via vectoral Co-A coupling)"]
[null,null,"Phosphatidylserine decarboxylase (n-C16:0)"]
[null,null,"Acyl-[acyl-carrier-protein] synthetase  (n-C16:1)"]
[null,null,"D-Glucosamine 6-phosphate transport via phosphate antiport (periplasm)"]
[null,null,"Phosphoglycerate mutase"]
[null,null,"Murein crosslinking transpeptidase 1A:(A2pm->D-ala) (periplasm)"]
[null,null,"Phosphatidylserine decarboxylase (n-C16:1)"]
[null,null,"Murein L,D-carboxypeptidase (murein5px4p) (periplasm)"]
[null,null,"Shikimate exchange"]
[null,null,"4-amino-4-deoxychorismate synthase"]
[null,null,"Protoporphyrinogen oxidase (anaerobic)"]
[null,null,"Bis-molybdopterin guanine dinucleotide synthase"]
[null,null,"Adenine transport via diffusion (extracellular to periplasm)"]
[null,null,"Fe-enterobactin transport via ABC system (periplasm)"]
[null,null,"Murein D,D-carboxypeptidase (murein5p4p) (periplasm)"]
[null,null,"Transketolase"]
[null,null,"1-octadec-7-enoyl-sn-glycerol 3-phosphate O-acyltransferase (n-C18:1)"]
[null,null,"FAD reductase"]
[null,null,"Adenine exchange"]
[null,null,"1,4-dihydroxy-2-napthoyl-CoA synthase"]
[null,null,"5-amino-6-(5-phosphoribosylamino)uracil reductase"]
[null,null,"Guanosine transport via diffusion (extracellular to periplasm)"]
[null,null,"Molybdopterin cytidine dinucleotide synthase"]
[null,null,"Dihydroneopterin aldolase reversible"]
[null,null,"Heme O synthase"]
[null,null,"H+ exchange"]
[null,null,"2-Oxogluterate dehydrogenase"]
[null,null,"Nucleoside-diphosphate kinase (ATP:GDP)"]
[null,null,"2-Oxoglutarate exchange"]
[null,null,"Cytidine transport via diffusion (extracellular to periplasm)"]
[null,null,"K+ exchange"]
[null,null,"Shikimate transport via diffusion (extracellular to periplasm)"]
[null,null,"Cytochrome oxidase bo3 (ubiquinol-8: 4 protons) (periplasm)"]
[null,null,"Lipoate exchange"]
[null,null,"Formate exchange"]
[null,null,"Cardiolipin synthase (periplasmic, n-C16:0)"]
[null,null,"Pantothenate transport via diffusion (extracellular to periplasm)"]
[null,null,"Biotin transport via diffusion (extracellular to periplasm)"]
[null,null,"Glycerol-3-phosphate acyltransferase (C16:0)"]
[null,null,"Phosphatidylglycerol phosphate phosphatase (n-C18:1)"]
[null,null,"2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase"]
[null,null,"Glucose-1-phosphate adenylyltransferase"]
[null,null,"Undecaprenyl diphosphate synthase"]
[null,null,"Phosphatidylethanolamine transport via ABC system (n-C18:1, periplasm)"]
[null,null,"Glutathione transport via diffusion (extracellular to periplasm)"]
[null,null,"Pantothenate sodium symporter (periplasm)"]
[null,null,"Nucleoside-diphosphate kinase (ATP:dGDP)"]
[null,null,"Shikimate kinase"]
[null,null,"L-Leucine exchange"]
[null,null,"Manganese (Mn+2) transport via diffusion (extracellular to periplasm)"]
[null,null,"3-Dimethylubiquinonol 3-methyltransferase"]
[null,null,"Glucosamine-1-phosphate N-acetyltransferase"]
[null,null,"Indole transport via diffusion (extracellular to periplasm)"]
[null,null,"D-Glucosamine 6-phosphate exchange"]
[null,null,"Guanosine transport in via proton symport (periplasm)"]
[null,null,"Glycerol 3-phosphate exchange"]
[null,null,"Pantetheine-phosphate adenylyltransferase"]
[null,null,"CDP-diacylglycerol synthetase (n-C18:1)"]
[null,null,"Phospho-N-acetylmuramoyl-pentapeptide-transferase (meso-2,6-diaminopimelate)"]
[null,null,"Pyridoxal import"]
[null,null,"Succinate exchange"]
[null,null,"NMN exchange"]
[null,null,"Formate transport via diffusion (extracellular to periplasm)"]
[null,null,"Glycerol-3-phosphate dehydrogenase (NADP)"]
[null,null,"Thiamine-phosphate kinase"]
[null,null,"Aspartate transaminase"]
[null,null,"L-leucine reversible transport via proton symport (periplasm)"]
[null,null,"2-succinyl-6-hydroxy-2,4-cyclohexadiene 1-carboxylate synthase"]
[null,null,"Phosphatidylglycerol synthase (n-C16:0)"]
[null,null,"Murein polymerizing transglycosylase 2 (three linked units)"]
[null,null,"Tripeptide (LalaDgluMdap) transport via ABC system (periplasm)"]
[null,null,"Chorismate pyruvate lyase"]
[null,null,"3-phosphoshikimate 1-carboxyvinyltransferase"]
[null,null,"Fatty-acid-CoA thioesterase (hexadecenoate)"]
[null,null,"Molybdopterin adenylyltransferase"]
[null,null,"Ferrochelatase"]
[null,null,"Iron (+2) transport in via permease (no H+)"]
[null,null,"Nucleoside-diphosphate kinase (ATP:UDP)"]
[null,null,"L-tyrosine transport via diffusion (extracellular to periplasm)"]
[null,null,"Guanosine exchange"]
[null,null,"Hydroxybenzoate octaprenyltransferase"]
[null,null,"Acetate reversible transport via proton symport (periplasm)"]
[null,null,"Coproporphyrinogen oxidase (O2 required)"]
[null,null,"Pantothenate kinase"]
[null,null,"Putrescine transport via diffusion (extracellular to periplasm)"]
[null,null,"Biotin exchange"]
[null,null,"Sulfate transport via diffusion (extracellular to periplasm)"]
[null,null,"Glycolate transport via diffusion (extracellular to periplasm)"]
[null,null,"Phosphatidylglycerol synthase (n-C16:1)"]
[null,null,"Fatty-acid-CoA thioesterase (hexadecanoate)"]
[null,null,"Glycogen synthase (ADPGlc)"]
[null,null,"UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine synthetase"]
[null,null,"1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase (dmpp)"]
[null,null,"E. coli biomass objective function (iJO1366) - WT - with 53.95 GAM estimate"]

{"sheet":"reaction ID","index":1,"n_rows":418,"n_cols":3,"rows_kept":418,"cut":false,"hidden":false,"merged":[[0,0,0,4]]}
["* Generated utilizing RIPTiDe with E.coli transcriptome growing in aerobic LB rich media"]
[]
["No_GPR","GPR","Both"]
["PGP181abcpp","EX_cu_e","NMNAT"]
["PGPP181pp","D_LACtex","NMNPtpp"]
["URItex","EX_pyr_e","OCDCEAtexi"]
["PFL","PDH","ALAtex"]
["AMPTASECG","PYRt2rpp","MG2tpp"]
["EX_cu2_e","CYStex","ADOCBLabcpp"]
["NO3tex","PYRtex","GLNS"]
["EX_no3_e","PG160abcpp","CLPNS161pp"]
["GPDDA3pp","EX_ser__L_e","EX_ac_e"]
["NTRIR3pp","EX_thymd_e","MMETt2pp"]
["EX_g3ps_e","THMDt2pp_copy1","ILEtex"]
["NO3t7pp","PG181abcpp","EX_his__L_e"]
["PGPP160pp","NDPK8","NDPK7"]
["MDDCP5pp","THD2pp","ALAR"]
["DURItex","SERtex","GRTT"]
["EX_duri_e","MLDCP3App","SHCHD2"]
["FLDR2","CYTD","EX_pro__L_e"]
["FDH5pp","EX_cys__L_e","MTHFR2"]
["RNTR1c2","RNDR1","PSSA161"]
["EX_uri_e","CU1Opp","NAt3_1p5pp"]
["DURIK1","MCTP1Bpp","HCYSMT2"]
["MLDCP2Bpp","EX_lac__D_e","SUCBZS"]
["ARGabcpp","MLDEP1pp","THMtex"]
["URIt2pp_copy1","D_LACt2pp","CA2tex"]
["CGLYabcpp","PTRCORNt7pp","DASYN160"]
["MLDCP2App","PG161abcpp","I2FE2SS"]
["G3PStex","CYSabcpp","EX_o2_e"]
["DURIt2pp","TMDK1","EX_met__L_e"]
["CGLYtex","ARGORNt7pp","NI2tex"]
["PGP161abcpp","LDH_D","FACOAE181"]
["EX_nh4_e","EX_no2_e","ALAt2pp_copy2"]
["PGPP161pp","CUtex","SUCCtex"]
["EX_cgly_e","THMDtex","UPPDC1"]
["PGP160abcpp","NO2tex","CLtex"]
["CU2tex",null,"PIt2rpp"]
["NO3R2pp",null,"EX_phe__L_e"]
["TMDS",null,"EX_LalaDgluMdap_e"]
["NH4tex",null,"DHNCOAT"]
["NADH17pp",null,"POR5"]
["ASNS2",null,"SERt2rpp"]
[null,null,"ALAALAr"]
[null,null,"GLYC3Pt6pp"]
[null,null,"FE2tex"]
[null,null,"DNMPPA"]
[null,null,"UAGCVT"]
[null,null,"EX_mn2_e"]
[null,null,"AKGt2rpp"]
[null,null,"LIPOtex"]
[null,null,"CHORS"]
[null,null,"GK1"]
[null,null,"MEPCT"]
[null,null,"GTPCII2"]
[null,null,"HDCAtexi"]
[null,null,"EX_adn_e"]
[null,null,"METAT"]
[null,null,"URIK2"]
[null,null,"MN2tpp"]
[null,null,"DHFS"]
[null,null,"EX_cytd_e"]
[null,null,"EX_colipa_e"]
[null,null,"THRA"]
[null,null,"SPMDtex"]
[null,null,"FESR"]
[null,null,"O2tpp"]
[null,null,"ADNt2pp_copy1"]
[null,null,"GCALDD"]
[null,null,"EX_feenter_e"]
[null,null,"EX_tyr__L_e"]
[null,null,"EX_ocdcea_e"]
[null,null,"MECDPDH5"]
[null,null,"PE161abcpp"]
[null,null,"DHNAOT4"]
[null,null,"BTNt2ipp"]
[null,null,"EX_mmet_e"]
[null,null,"MOGDS"]
[null,null,"DMATT"]
[null,null,"TPI"]
[null,null,"OMPHHX"]
[null,null,"PItex"]
[null,null,"EX_cobalt2_e"]
[null,null,"EX_thm_e"]
[null,null,"PHEtex"]
[null,null,"EX_asn__L_e"]
[null,null,"PGMT"]
[null,null,"I4FE4SR"]
[null,null,"OMBZLM"]
[null,null,"UM3PL"]
[null,null,"ADOCBLtonex"]
[null,null,"EX_mobd_e"]
[null,null,"DPCOAK"]
[null,null,"EX_pydx_e"]
[null,null,"DADNtex"]
[null,null,"PUNP2"]
[null,null,"UPP3MT"]
[null,null,"HPPK2"]
[null,null,"3PEPTtex"]
[null,null,"DHPPDA2"]
[null,null,"SO4t2pp"]
[null,null,"IPDPS"]
[null,null,"DHFR"]
[null,null,"O2tex"]
[null,null,"PGPP161"]
[null,null,"DADNt2pp"]
[null,null,"EX_so4_e"]
[null,null,"SPMDabcpp"]
[null,null,"EX_dad_2_e"]
[null,null,"ADEt2rpp"]
[null,null,"EX_cl_e"]
[null,null,"GTHRDabcpp"]
[null,null,"COBALT2tpp"]
[null,null,"PYDXK"]
[null,null,"FORtppi"]
[null,null,"DM_mththf_c"]
[null,null,"ACtex"]
[null,null,"DASYN161"]
[null,null,"ICYSDS"]
[null,null,"RBFSa"]
[null,null,"EX_arg__L_e"]
[null,null,"EX_zn2_e"]
[null,null,"GLYCtex"]
[null,null,"MTHTHFSs"]
[null,null,"RNDR2"]
[null,null,"PGAMT"]
[null,null,"DNTPPA"]
[null,null,"MPTSS"]
[null,null,"TALA"]
[null,null,"GLUTRS"]
[null,null,"OCTDPS"]
[null,null,"HCO3E"]
[null,null,"ADK1"]
[null,null,"OPHHX"]
[null,null,"RHCCE"]
[null,null,"PYK"]
[null,null,"AMMQLT8"]
[null,null,"NDPK4"]
[null,null,"FESD1s"]
[null,null,"EX_hdcea_e"]
[null,null,"PTAr"]
[null,null,"EX_pnto__R_e"]
[null,null,"Htex"]
[null,null,"GLYCLTt2rpp"]
[null,null,"RBFSb"]
[null,null,"EX_thr__L_e"]
[null,null,"INDOLEt2rpp"]
[null,null,"EX_glyc_e"]
[null,null,"HDCEAtexi"]
[null,null,"FLVRx"]
[null,null,"ALATA_L"]
[null,null,"EX_pi_e"]
[null,null,"EX_gthrd_e"]
[null,null,"NADH16pp"]
[null,null,"ASNtex"]
[null,null,"MG2tex"]
[null,null,"EX_co2_e"]
[null,null,"TKT2"]
[null,null,"AACPS5"]
[null,null,"PSSA181"]
[null,null,"DB4PS"]
[null,null,"DRPA"]
[null,null,"MCTP2App"]
[null,null,"PPNCL2"]
[null,null,"UPP3S"]
[null,null,"EX_ile__L_e"]
[null,null,"ACKr"]
[null,null,"ACALD"]
[null,null,"DALAtex"]
[null,null,"PGI"]
[null,null,"PSSA160"]
[null,null,"UAGDP"]
[null,null,"HIStex"]
[null,null,"PPBNGS"]
[null,null,"ILEt2rpp"]
[null,null,"EX_ala__L_e"]
[null,null,"MDDCP1pp"]
[null,null,"GAMAN6Ptex"]
[null,null,"G3PAT181"]
[null,null,"CO2tpp"]
[null,null,"VALt2rpp"]
[null,null,"EX_spmd_e"]
[null,null,"MDDCP3pp"]
[null,null,"LIPAMPL"]
[null,null,"LIPOt2pp"]
[null,null,"CU2tpp"]
[null,null,"THMabcpp"]
[null,null,"EX_alaala_e"]
[null,null,"Kt2pp"]
[null,null,"MTHFC"]
[null,null,"AACPS3"]
[null,null,"RNDR3"]
[null,null,"H2Otex"]
[null,null,"HMBS"]
[null,null,"UAPGR"]
[null,null,"GLUDy"]
[null,null,"PE160abcpp"]
[null,null,"LEUtex"]
[null,null,"GTPCI"]
[null,null,"RPI"]
[null,null,"SUCDi"]
[null,null,"HISt2rpp"]
[null,null,"ATPM"]
[null,null,"MDH"]
[null,null,"FEENTERR3"]
[null,null,"SKMt2pp"]
[null,null,"EX_hdca_e"]
[null,null,"THRtex"]
[null,null,"EX_h2o_e"]
[null,null,"GAPD"]
[null,null,"EX_ptrc_e"]
[null,null,"ICHORS_copy1"]
[null,null,"VALtex"]
[null,null,"PMDPHT"]
[null,null,"PGSA181"]
[null,null,"PPM2"]
[null,null,"MPTS"]
[null,null,"NMNtex"]
[null,null,"EX_mg2_e"]
[null,null,"MOBDabcpp"]
[null,null,"SUCOAS"]
[null,null,"DXPS"]
[null,null,"CO2tex"]
[null,null,"MDDCP2pp"]
[null,null,"MOCOS"]
[null,null,"ZN2tpp"]
[null,null,"DHPS2"]
[null,null,"PROtex"]
[null,null,"NADK"]
[null,null,"AHCYSNS"]
[null,null,"ADNtex"]
[null,null,"EX_ca2_e"]
[null,null,"PGK"]
[null,null,"PYDXtex"]
[null,null,"GSNK"]
[null,null,"TRDR"]
[null,null,"ASNt2rpp"]
[null,null,"OHPHM"]
[null,null,"LYStex"]
[null,null,"MTHFD"]
[null,null,"ADNK1"]
[null,null,"OMMBLHX"]
[null,null,"EX_val__L_e"]
[null,null,"NO2t2rpp"]
[null,null,"ENO"]
[null,null,"DTMPK"]
[null,null,"RPE"]
[null,null,"LIPATPT"]
[null,null,"FMNAT"]
[null,null,"ATPS4rpp"]
[null,null,"BMOGDS1"]
[null,null,"GLUTRR"]
[null,null,"PGPP160"]
[null,null,"Zn2tex"]
[null,null,"SUCBZL"]
[null,null,"AGPAT160"]
[null,null,"DXPRIi"]
[null,null,"AGPAT161"]
[null,null,"I2FE2ST"]
[null,null,"ADCL"]
[null,null,"UAGPT3"]
[null,null,"UMPK"]
[null,null,"FACOAL181t2pp"]
[null,null,"PSD181"]
[null,null,"UDCPDP"]
[null,null,"COBALT2tex"]
[null,null,"EX_ala__D_e"]
[null,null,"GHMT2r"]
[null,null,"SUCCt3pp"]
[null,null,"MECDPS"]
[null,null,"LYSt2pp"]
[null,null,"TYRt2rpp"]
[null,null,"NDPK3"]
[null,null,"EX_lys__L_e"]
[null,null,"TRPAS2"]
[null,null,"FUM"]
[null,null,"CPMPS"]
[null,null,"RBFK"]
[null,null,"CDPMEK"]
[null,null,"EX_indole_e"]
[null,null,"PROt2rpp"]
[null,null,"EX_fe2_e"]
[null,null,"AKGtex"]
[null,null,"PPK"]
[null,null,"CYTK1"]
[null,null,"ALAALAtex"]
[null,null,"MPTG"]
[null,null,"MOX"]
[null,null,"MMETtex"]
[null,null,"PHEt2rpp"]
[null,null,"METtex"]
[null,null,"PPM"]
[null,null,"G3PAT161"]
[null,null,"CLPNS181pp"]
[null,null,"NTRIR2x"]
[null,null,"PTRCt2pp"]
[null,null,"CAt6pp"]
[null,null,"SHCHF"]
[null,null,"FEENTERtonex"]
[null,null,"GLYC3Ptex"]
[null,null,"DHPTDCs2"]
[null,null,"I4FE4ST"]
[null,null,"ACCOAC"]
[null,null,"MOBDtex"]
[null,null,"PUNP1"]
[null,null,"I2FE2SS2"]
[null,null,"FACOAL161t2pp"]
[null,null,"OPHBDC"]
[null,null,"CLt3_2pp"]
[null,null,"EX_glyclt_e"]
[null,null,"EX_adocbl_e"]
[null,null,"NI2tpp"]
[null,null,"EX_ni2_e"]
[null,null,"METabcpp"]
[null,null,"BMOCOS"]
[null,null,"TMK"]
[null,null,"Ktex"]
[null,null,"MOADSUx"]
[null,null,"PPCDC"]
[null,null,"CYTDK2"]
[null,null,"THRt4pp"]
[null,null,"ARGtex"]
[null,null,"G1SAT"]
[null,null,"FACOAL160t2pp"]
[null,null,"PSD160"]
[null,null,"AACPS4"]
[null,null,"GAM6Pt6_2pp"]
[null,null,"PGM"]
[null,null,"MCTP1App"]
[null,null,"PSD161"]
[null,null,"MLDCP1App"]
[null,null,"EX_skm_e"]
[null,null,"ADCS"]
[null,null,"PPPGO3"]
[null,null,"BMOGDS2"]
[null,null,"ADEtex"]
[null,null,"FEENTERabcpp"]
[null,null,"MDDCP4pp"]
[null,null,"TKT1"]
[null,null,"AGPAT181"]
[null,null,"FADRx"]
[null,null,"EX_ade_e"]
[null,null,"DHNCOAS"]
[null,null,"APRAUR"]
[null,null,"GSNtex"]
[null,null,"MOCDS"]
[null,null,"DHNPA2r"]
[null,null,"HEMEOS"]
[null,null,"EX_h_e"]
[null,null,"AKGDH"]
[null,null,"NDPK1"]
[null,null,"EX_akg_e"]
[null,null,"CYTDtex"]
[null,null,"EX_k_e"]
[null,null,"SKMtex"]
[null,null,"CYTBO3_4pp"]
[null,null,"EX_lipoate_e"]
[null,null,"EX_for_e"]
[null,null,"CLPNS160pp"]
[null,null,"PNTOtex"]
[null,null,"BTNtex"]
[null,null,"G3PAT160"]
[null,null,"PGPP181"]
[null,null,"SEPHCHCS"]
[null,null,"GLGC"]
[null,null,"UDCPDPS"]
[null,null,"PE181abcpp"]
[null,null,"GTHRDtex"]
[null,null,"PNTOt4pp"]
[null,null,"NDPK5"]
[null,null,"SHKK"]
[null,null,"EX_leu__L_e"]
[null,null,"MNtex"]
[null,null,"DMQMT"]
[null,null,"G1PACT"]
[null,null,"INDOLEtex"]
[null,null,"EX_gam6p_e"]
[null,null,"GSNt2pp"]
[null,null,"EX_glyc3p_e"]
[null,null,"PTPATi"]
[null,null,"DASYN181"]
[null,null,"PAPPT3"]
[null,null,"PYDXtpp"]
[null,null,"EX_succ_e"]
[null,null,"EX_nmn_e"]
[null,null,"CYTDt2pp_copy1"]
[null,null,"FORtex"]
[null,null,"G3PD2"]
[null,null,"TMPK"]
[null,null,"ASPTA"]
[null,null,"LEUt2rpp"]
[null,null,"SHCHCS3"]
[null,null,"PGSA160"]
[null,null,"MPTG2"]
[null,null,"3PEPTabcpp"]
[null,null,"CHRPL"]
[null,null,"PSCVT"]
[null,null,"FACOAE161"]
[null,null,"MPTAT"]
[null,null,"FCLT"]
[null,null,"FE2tpp"]
[null,null,"NDPK2"]
[null,null,"TYRtex"]
[null,null,"EX_gsn_e"]
[null,null,"HBZOPT"]
[null,null,"ACt2rpp"]
[null,null,"CPPPGO"]
[null,null,"PNTK"]
[null,null,"PTRCtex"]
[null,null,"EX_btn_e"]
[null,null,"SO4tex"]
[null,null,"GLYCLTtex"]
[null,null,"PGSA161"]
[null,null,"FACOAE160"]
[null,null,"GLCS1"]
[null,null,"UGMDDS"]
[null,null,"DMPPS"]
[null,null,"BIOMASS_Ec_iJO1366_WT_53p95M"]