# Supplementary Data 1. GWAS meta-analysis association loci for WMH.,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
# TRAIT: Analyzed trait,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
# CHROM: Chromosome,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
# POS: Position in bp,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
# MarkerName: SNP ID,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
# Allele1: Tested allele,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
# Allele2: Non-tested allele,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
# Weight: Weight for the meta-analysis,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
# Zscore: Z-score statistic for the meta-analysis,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
# P-value: P-value of the meta-analysis,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
# Direction: Study-specific direction of the SNP z-score,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
# HetISq: Percentage of variation across studies that is due to heterogeneity ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
# HetChiSq: Heterogeneity test statistic ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
# HetDf: Heterogeneity test statistic degrees of freedom ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
# HetPVal: Heterogeneity p-value ,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
# TotalSampleSize: Total sample size in the meta-analysis,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
# A1_FREQ_UKBB: Frequency of the tested allele in UK Biobank dataset,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
# BETA_UKBB: beta coefficient in the UK Biobank study,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
# SE_UKBB: Standard error for the beta coefficient in the UK Biobank study,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
# T_STAT_UKBB: T statistics in the UK Biobank study,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
# P_UKBB: P-value in the UK Biobank study,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
# INFO_UKBB: Imputation INFO score in UK Biobank study,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
# N_CHARGE: sample size in the CHARGE study,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
# Zscore_CHARGE: z-score in the CHARGE study,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
# P_CHARGE: P-value in the CHARGE study,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
# BETA_Traylor: Beta coefficient in the Traylor et al. (2019) study,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
# SE_Traylor: Standard error for the beta coefficient in the Traylor et al. (2019) study,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
# P_Traylor: P-value in the Traylor et al. (2019) study,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
#N_Traylor: Sample size in the Traylor et al. (2019) study,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
# Zscore_European : Z-score statistic for the meta-analysis with only European ancestry samples,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
# P-value_European:  P-value of the meta-analysis with only European ancestry samples,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
# TotalSampleSize_European: Total sample size in the meta-analysis with only European ancestry samples,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
# Zscore_UKB_CHARGE: Z-score statistic for the meta-analysis with only UK Biobank and CHARGE GWAS studies,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
# P-value_UKB_CHARGE: P-value of the meta-analysis with only UK Biobank and CHARGE GWAS studies,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
# TotalSampleSize_UKB_CHARGE: Total sample size in the meta-analysis with only UK Biobank and CHARGE GWAS studies,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
TRAIT,CHROM,POS,MarkerName,Allele1,Allele2,Weight,Zscore,P-value,Direction,HetISq,HetChiSq,HetDf,HetPVal,TotalSampleSize,A1_FREQ_UKBB,BETA_UKBB,SE_UKBB,T_STAT_UKBB,P_UKBB,INFO_UKBB,N_CHARGE,Zscore_CHARGE,P_CHARGE,BETA_Traylor,SE_Traylor,P_Traylor,N_Traylor,Zscore_European,P-value_European,TotalSampleSize_European,Zscore_UKB_CHARGE,P-value_UKB_CHARGE,TotalSampleSize_UKB_CHARGE
WMH,1,197499003,rs12120143,T,C,31570,5.805,6.45E-09,+++,23.7,2.622,2,0.2695,31570,0.0246994,0.105635,0.0310188,3.40553,0.000662,1,10440.00 ,4.566,4.97E-06,0.2855,0.145,4.90E-02,2749,5.186,2.15E-07,28151,5.467,4.57E-08,28821
WMH,2,43118872,rs7566761,A,G,41920,-7.168,7.62E-13,---,0,1.653,2,0.4376,41920,0.196386,-0.067004,0.0121461,-5.51651,3.50E-08,0.985297,20689,-4.67,3.02E-06,-0.0449,0.0497,3.66E-01,2850,-7.521,5.44E-14,36317,-7.18,6.96E-13,39070
WMH,2,56128091,rs7596872,A,C,41920,9.259,2.07E-20,+++,50.8,4.066,2,0.131,41920,0.101453,0.122162,0.0159969,7.63662,2.34E-14,0.987256,20689.00 ,5.349,8.85E-08,0.1107,0.0644,8.54E-02,2850,8.994,2.38E-19,36317,9.126,7.10E-20,39070
WMH,2,188003118,rs17576323,T,C,41228,5.533,3.15E-08,+++,0,0.09,2,0.9562,41228,0.201688,0.0417669,0.0119824,3.48568,0.000492,0.993683,20098.00 ,4.075,4.61E-05,0.0674,0.0482,1.62E-01,2749,5.23,1.69E-07,36317,5.354,8.62E-08,38479
WMH,2,203916487,rs72934505,T,G,42124,7.246,4.31E-13,+++,0,1.06,2,0.5886,42124,0.126653,0.0601115,0.0144536,4.15892,3.21E-05,0.998714,20893.00 ,5.414,6.18E-08,0.1661,0.063,8.32E-03,2850,6.779,1.21E-11,36317,6.793,1.10E-11,39274
WMH,3,183380035,rs830179,A,G,42124,-5.858,4.67E-09,---,5.2,2.109,2,0.3484,42124,0.317416,-0.0458688,0.0103935,-4.41324,1.02E-05,0.9899,20893,-3.242,1.19E-03,-0.1064,0.0419,1.11E-02,2850,-5.056,4.29E-07,36317,-5.383,7.33E-08,39274
WMH,5,121510586,rs17148926,A,C,42123.99,5.881,4.07E-09,+++,74.4,7.819,2,0.02005,42124,0.173317,0.0278172,0.0127173,2.18735,0.0287,0.987025,20892.99 ,4.974,6.57E-07,0.1889,0.0526,3.31E-04,2850,4.66,3.16E-06,36317,5.124,2.99E-07,39274
WMH,6,151016058,rs275350,C,G,42124,8.32,8.83E-17,+++,0,1.666,2,0.4347,42124,0.413508,0.0590091,0.00977129,6.03903,1.58E-09,0.997323,20893.00 ,5.042,4.61E-07,0.1192,0.0397,2.66E-03,2850,7.592,3.15E-14,36317,7.807,5.87E-15,39274
WMH,7,100361391,rs3215395,G,GC,18381,5.597,2.18E-08,+??,0,0,0,1,18381,0.290129,0.0593947,0.0106072,5.59948,2.18E-08,0.998346,NA,NA,NA,NA,NA,NA,NA,5.597,2.18E-08,18381,5.597,2.18E-08,18381
WMH,10,105459116,rs4630220,A,G,42124,-7.715,1.21E-14,---,0,0.676,2,0.7132,42124,0.284718,-0.0532747,0.0107705,-4.94633,7.63E-07,0.980825,20893,-5.283,1.27E-07,-0.1225,0.0437,5.10E-03,2850,-7.352,1.95E-13,36317,-7.236,4.63E-13,39274
WMH,13,111040681,rs11838776,A,G,42035,6.503,7.90E-11,+++,76.6,8.545,2,0.01394,42035,0.278134,0.0335817,0.0108438,3.09687,0.00196,0.975403,20804.00 ,4.721,2.34E-06,0.1873,0.043,1.34E-05,2850,5.471,4.47E-08,36228,5.561,2.68E-08,39185
WMH,14,100581636,rs11160570,T,C,42035,7.198,6.10E-13,+++,0,1.205,2,0.5474,42035,0.25499,0.0484136,0.0110764,4.3709,1.24E-05,0.998303,20804.00 ,5.051,4.39E-07,0.1305,0.045,3.73E-03,2850,6.475,9.46E-11,36228,6.673,2.50E-11,39185
WMH,15,65326833,rs12906662,A,T,42035,-5.805,6.42E-09,---,0,0.044,2,0.9784,42035,0.472855,-0.0369678,0.00967705,-3.82015,0.000134,0.993423,20804,-4.172,3.02E-05,-0.0531,0.0401,1.86E-01,2850,-5.915,3.31E-09,36228,-5.656,1.55E-08,39185
WMH,16,51451683,rs17616633,T,C,42124.01,-6.514,7.33E-11,---,48.1,3.856,2,0.1454,42124,0.439418,-0.0520153,0.00972716,-5.34743,9.03E-08,0.986353,20893.01,-3.246,1.17E-03,-0.107,0.0399,7.38E-03,2850,-5.929,3.05E-09,36317,-6.024,1.70E-09,39274
WMH,16,87237568,rs12928520,T,C,41387,7.41,1.26E-13,+++,0,0.89,2,0.6409,41387,0.443162,0.0546724,0.00981806,5.56855,2.60E-08,0.964408,20156.00 ,4.795,1.62E-06,0.0542,0.0401,1.77E-01,2850,7.26,3.88E-13,35580,7.312,2.63E-13,38537
WMH,17,19224397,rs6587216,C,G,41920,5.768,8.01E-09,+++,0,0.469,2,0.791,41920,0.185929,0.0523434,0.0123896,4.22479,2.40E-05,0.997317,20689.00 ,3.571,3.56E-04,0.0885,0.0499,7.58E-02,2850,5.103,3.35E-07,36317,5.495,3.90E-08,39070
WMH,17,43128906,rs8071429,A,T,42035,8.19,2.61E-16,+++,65.9,5.862,2,0.05334,42035,0.373257,0.0720442,0.0099624,7.23161,4.96E-13,0.999123,20804.00 ,4.332,1.48E-05,0.0563,0.0403,1.62E-01,2850,7.569,3.77E-14,36228,8.106,5.25E-16,39185
WMH,17,73882148,rs7214628,A,G,42035,-12.532,4.99E-36,---,13.1,2.301,2,0.3164,42035,0.187969,-0.106953,0.0122036,-8.76404,2.05E-18,0.99737,20804,-8.91,5.12E-19,-0.0921,0.0505,6.83E-02,2850,-12.54,4.53E-36,36228,-12.488,8.68E-36,39185
WMH,19,45411941,rs429358,T,C,38894,-6.088,1.15E-09,---,0,1.299,2,0.5222,38894,0.149693,-0.0664718,0.0134667,-4.936,8.04E-07,1,17663,-3.625,2.89E-04,-0.0527,0.0564,3.50E-01,2850,-5.711,1.12E-08,33087,-6.061,1.35E-09,36044