Authors,Author(s) ID,Title,Year,Source title,Volume,Issue,Art. No.,Page start,Page end,Page count,Cited by,DOI,Link,Affiliations,Authors with affiliations,Abstract,Author Keywords,Index Keywords,References,Correspondence Address,Editors,Publisher,ISSN,ISBN,CODEN,PubMed ID,Language of Original Document,Abbreviated Source Title,Document Type,Publication Stage,Access Type,Source,EID,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Pillaiyar T., Meenakshisundaram S., Manickam M.",57194781059;57191636817;56396425700;,Recent discovery and development of inhibitors targeting coronaviruses,2020,Drug Discovery Today,,,,,,,2,10.1016/j.drudis.2020.01.015,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079904000&doi=10.1016%2fj.drudis.2020.01.015&partnerID=40&md5=aac9e44049ba539f4e110f96a960e285,"PharmaCenter Bonn, Pharmaceutical Institute, Department of Pharmaceutical and Medicinal Chemistry, University of Bonn, An der Immenburg 4, Bonn, D-53121, Germany; Department of Chemistry, Sri Krishna College of Engineering and Technology, Coimbatore, Tamil Nadu, India; Department of Chemistry, PSG Institute of Technology and Applied Research, Coimbatore, Tamil Nadu, India","Pillaiyar, T., PharmaCenter Bonn, Pharmaceutical Institute, Department of Pharmaceutical and Medicinal Chemistry, University of Bonn, An der Immenburg 4, Bonn, D-53121, Germany; Meenakshisundaram, S., Department of Chemistry, Sri Krishna College of Engineering and Technology, Coimbatore, Tamil Nadu, India; Manickam, M., Department of Chemistry, PSG Institute of Technology and Applied Research, Coimbatore, Tamil Nadu, India","Human coronaviruses (CoVs) are enveloped viruses with a positive-sense single-stranded RNA genome. 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Transl., 11, p. 9242","Pillaiyar, T.; PharmaCenter Bonn, Pharmaceutical Institute, Department of Pharmaceutical and Medicinal Chemistry, University of Bonn, An der Immenburg 4, Germany; email: thanigai@uni-bonn.deand",,Elsevier Ltd,13596446,,DDTOF,32006468,English,Drug Discov. Today,Review,Article in Press,Open Access,Scopus,2-s2.0-85079904000,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Chang L., Yan Y., Wang L.",57213079611;57215880892;8450868300;,Coronavirus Disease 2019: Coronaviruses and Blood Safety,2020,Transfusion Medicine Reviews,,,,,,,1,10.1016/j.tmrv.2020.02.003,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082228140&doi=10.1016%2fj.tmrv.2020.02.003&partnerID=40&md5=01d8c43f6365c75caf82e03dc4ce8530,"National Center for Clinical Laboratories, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijin, China; Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, China; Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China","Chang, L., National Center for Clinical Laboratories, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijin, China, Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, China; Yan, Y., National Center for Clinical Laboratories, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijin, China, Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, China; Wang, L., National Center for Clinical Laboratories, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijin, China, Beijing Engineering Research Center of Laboratory Medicine, Beijing Hospital, China, Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China","With the outbreak of unknown pneumonia in Wuhan, China, in December 2019, a new coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), aroused the attention of the entire world. The current outbreak of infections with SARS-CoV-2 is termed Coronavirus Disease 2019 (COVID-19). The World Health Organization declared COVID-19 in China as a Public Health Emergency of International Concern. Two other coronavirus infections—SARS in 2002-2003 and Middle East Respiratory Syndrome (MERS) in 2012—both caused severe respiratory syndrome in humans. All 3 of these emerging infectious diseases leading to a global spread are caused by β-coronaviruses. Although coronaviruses usually infect the upper or lower respiratory tract, viral shedding in plasma or serum is common. Therefore, there is still a theoretical risk of transmission of coronaviruses through the transfusion of labile blood products. Because more and more asymptomatic infections are being found among COVID-19 cases, considerations of blood safety and coronaviruses have arisen especially in endemic areas. In this review, we detail current evidence and understanding of the transmission of SARS-CoV, MERS–CoV, and SARS-CoV-2 through blood products as of February 10, 2020, and also discuss pathogen inactivation methods on coronaviruses. © 2020 Elsevier Inc.",2019-nCoV; Blood safety; Coronavirus; COVID-19; MERS; Pathogen inactivation technology; SARS; SARS-CoV-2,,"Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan (2020) China. 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Ding, Y., Wang, H., Shen, H., Li, Z., Geng, J., Han, H., The clinical pathology of severe acute respiratory syndrome (SARS): a report from China (2003) J Pathol, 200, pp. 282-289; de Wit, E., van Doremalen, N., Falzarano, D., Munster, V.J., SARS and MERS: recent insights into emerging coronaviruses (2016) Nat Rev Microbiol, 14, pp. 523-534; Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med; Cheng, P.K., Wong, D.A., Tong, L.K., Ip, S.M., Lo, A.C., Lau, C.S., Viral shedding patterns of coronavirus in patients with probable severe acute respiratory syndrome (2004) Lancet, 363, pp. 1699-1700; Hui, D.S.C., Zumla, A., Severe acute respiratory syndrome: historical, epidemiologic, and clinical features (2019) Infect Dis Clin North Am, 33, pp. 869-889; US Food and Drug Administration., (2003), https://www.fda.gov/media/124354/download;, Revised recommendations for the assessment of donor suitability and blood product safety in cases of suspected severe acute respiratory syndrome (SARS) or exposure to SARS: guidance for industry; 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Schmidt, M., Brixner, V., Ruster, B., Hourfar, M.K., Drosten, C., Preiser, W., NAT screening of blood donors for severe acute respiratory syndrome coronavirus can potentially prevent transfusion associated transmissions (2004) Transfusion, 44, pp. 470-475. , http://doi.org/10.1111/j.1537-2995.2004.03269.x; Woo, P.C., Lau, S.K., Tsoi, H.W., Chan, K.H., Wong, B.H., Che, X.Y., Relative rates of non-pneumonic SARS coronavirus infection and SARS coronavirus pneumonia (2004) Lancet, 363, pp. 841-845; Zhou, Y.H., Prevalence of non-pneumonic infections with SARS-correlated virus (2004) Lancet, 363, pp. 1825-1826. , author reply 6-7; Young, M., (1826), Prevalence of non-pneumonic infections with SARS-correlated virus. Lancet 2004;363 author reply -7; Yip, C.W., Hon, C.C., Zeng, F., Chow, K.Y., Leung, F.C., Prevalence of non-pneumonic infections with SARS-correlated virus (2004) Lancet, 363, p. 1825. , author reply 6-7; Theron, M., Prevalence of non-pneumonic infections with SARS-correlated virus (2004) Lancet, 363, p. 1825. , author reply 6-7; Shang, G., Biggerstaff, B.J., Yang, B., Shao, C., Farrugia, A., Theoretically estimated risk of severe acute respiratory syndrome transmission through blood transfusion during an epidemic in Shenzhen, Guangdong, China in 2003 (2007) Transfus Apher Sci, 37, pp. 233-240; Zaki, A.M., van Boheemen, S., Bestebroer, T.M., Osterhaus, A.D., Fouchier, R.A., Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia (2012) N Engl J Med, 367, pp. 1814-1820; Chafekar, A., Fielding, B.C., MERS-CoV: understanding the latest human coronavirus threat (2018) Viruses, 10; http://www.aabb.org/tm/eid/Documents/middle-east-respiratory-syndrome-coronavirus.pdf;, American Association of Blood Banks. Middle East respiratory syndrome coronavirus, 2013 [accessed 2020-2-5]; Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med; Chan, J.F., Yuan, S., Kok, K.H., To, K.K., Chu, H., Yang, J., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet; Phan, L.T., Nguyen, T.V., Luong, Q.C., Nguyen, T.V., Nguyen, H.T., Le, H.Q., Importation and human-to-human transmission of a novel coronavirus in Vietnam (2020) N Engl J Med; Rothe, C., Schunk, M., Sothmann, P., Bretzel, G., Froeschl, G., Wallrauch, C., Transmission of 2019-nCoV infection from an asymptomatic contact in Germany (2020) N Engl J Med; Holshue, M.L., DeBolt, C., Lindquist, S., Lofy, K.H., Wiesman, J., Bruce, H., First case of 2019 novel coronavirus in the United States (2020) N Engl J Med; https://www.ecdc.europa.eu/sites/default/files/documents/Risk-assessment-pneumonia-Wuhan-China-22-Jan-2020.pdf;, Control Ecfdpa. Outbreak of acute respiratory syndrome associated with a novel coronavirus, Wuhan, China; first update, 2020 [accessed 2020-2-5]; http://www.aabb.org/advocacy/regulatorygovernment/Documents/Impact-of-2019-Novel-Coronavirus-on-Blood-Donation.pdf;, American Association of Blood Banks. Update: impact of 2019 novel coronavirus and blood safety, 2020 [accessed 2020-2-5]; Rabenau, H.F., Cinatl, J., Morgenstern, B., Bauer, G., Preiser, W., Doerr, H.W., Stability and inactivation of SARS coronavirus (2005) Med Microbiol Immunol, 194, pp. 1-6; Lamarre, A., Talbot, P.J., Effect of pH and temperature on the infectivity of human coronavirus 229E (1989) Can J Microbiol, 35, pp. 972-974; Eickmann, M., Gravemann, U., Handke, W., Tolksdorf, F., Reichenberg, S., Muller, T.H., Inactivation of three emerging viruses—severe acute respiratory syndrome coronavirus, Crimean-Congo haemorrhagic fever virus and Nipah virus—in platelet concentrates by ultraviolet C light and in plasma by methylene blue plus visible light (2020) Vox Sang; Hashem, A.M., Hassan, A.M., Tolah, A.M., Alsaadi, M.A., Abunada, Q., Damanhouri, G.A., Amotosalen and ultraviolet A light efficiently inactivate MERS-coronavirus in human platelet concentrates (2019) Transfus Med, 29, pp. 434-441; Hindawi, S.I., Hashem, A.M., Damanhouri, G.A., El-Kafrawy, S.A., Tolah, A.M., Hassan, A.M., Inactivation of Middle East respiratory syndrome-coronavirus in human plasma using amotosalen and ultraviolet A light (2018) Transfusion, 58, pp. 52-59; Eickmann, M., Gravemann, U., Handke, W., Tolksdorf, F., Reichenberg, S., Muller, T.H., Inactivation of Ebola virus and Middle East respiratory syndrome coronavirus in platelet concentrates and plasma by ultraviolet C light and methylene blue plus visible light, respectively (2018) Transfusion, 58, pp. 2202-2207; Darnell, M.E., Taylor, D.R., Evaluation of inactivation methods for severe acute respiratory syndrome coronavirus in noncellular blood products (2006) Transfusion, 46, pp. 1770-1777. , http://doi.org/10.1111/j.1537-2995.2006.00976.x; Rabenau, H.F., Biesert, L., Schmidt, T., Bauer, G., Cinatl, J., Doerr, H.W., SARS-coronavirus (SARS-CoV) and the safety of a solvent/detergent (S/D) treated immunoglobulin preparation. Biologicals 2005;33: 95-9; Lin, L., Hanson, C.V., Alter, H.J., Jauvin, V., Bernard, K.A., Murthy, K.K., Inactivation of viruses in platelet concentrates by photochemical treatment with amotosalen and long-wavelength ultraviolet light (2005) Transfusion, 45, pp. 580-590. , http://doi.org/10.1111/j.0041-1132.2005.04316.x; Yunoki, M., Urayama, T., Yamamoto, I., Abe, S., Ikuta, K., Heat sensitivity of a SARS-associated coronavirus introduced into plasma products (2004) Vox Sang, 87, pp. 302-303. , http://doi.org/10.1111/j.1423-0410.2004.00577.x; Leclercq, I., Batejat, C., Burguiere, A.M., Manuguerra, J.C., Heat inactivation of the Middle East respiratory syndrome coronavirus (2014) Influenza Other Respir Viruses, 8, pp. 585-586; Keil, S.D., Bowen, R., Marschner, S., Inactivation of Middle East respiratory syndrome coronavirus (MERS-CoV) in plasma products using a riboflavin-based and ultraviolet light-based photochemical treatment (2016) Transfusion, 56, pp. 2948-2952; Rebulla, P., The long and winding road to pathogen reduction of platelets, red blood cells and whole blood (2019) Br J Haematol, 186, pp. 655-667; Seltsam, A., Muller, T.H., Update on the use of pathogen-reduced human plasma and platelet concentrates (2013) Br J Haematol, 162, pp. 442-454; https://www.csbt.org.cn/plus/view.php?aid=16530;, Chinese Society of Blood Transfusion. Recommendations on blood collection and supply during the epidemic of novel coronavirus pneumonia in China (1st edition) [Chinese], 2020 [accessed 2020-2-5]","Wang, L.No. 1 Dahua Rd, China; email: lunan99@163.com",,W.B. Saunders,8877963,,TMERE,,English,Transfus. Med. Rev.,Review,Article in Press,Open Access,Scopus,2-s2.0-85082228140,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Madjid M., Safavi-Naeini P., Solomon S.D., Vardeny O.",6701497659;56440093400;7401460954;14021848500;,Potential Effects of Coronaviruses on the Cardiovascular System: A Review,2020,JAMA Cardiology,,,,,,,1,10.1001/jamacardio.2020.1286,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082446589&doi=10.1001%2fjamacardio.2020.1286&partnerID=40&md5=f14268a3ed02d15b3b871534d69aef17,"McGovern Medical School, Department of Medicine, University of Texas Health Science Center at Houston, 6431 Fannin, MSB 1.246, Houston, TX 77030, United States; Texas Heart Institute, Houston, United States; Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States; University of Minnesota, Minneapolis, United States","Madjid, M., McGovern Medical School, Department of Medicine, University of Texas Health Science Center at Houston, 6431 Fannin, MSB 1.246, Houston, TX 77030, United States; Safavi-Naeini, P., Texas Heart Institute, Houston, United States; Solomon, S.D., Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States; Vardeny, O., University of Minnesota, Minneapolis, United States","Importance: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19) has reached a pandemic level. Coronaviruses are known to affect the cardiovascular system. We review the basics of coronaviruses, with a focus on COVID-19, along with their effects on the cardiovascular system. Observations: Coronavirus disease 2019 can cause a viral pneumonia with additional extrapulmonary manifestations and complications. A large proportion of patients have underlying cardiovascular disease and/or cardiac risk factors. Factors associated with mortality include male sex, advanced age, and presence of comorbidities including hypertension, diabetes mellitus, cardiovascular diseases, and cerebrovascular diseases. Acute cardiac injury determined by elevated high-sensitivity troponin levels is commonly observed in severe cases and is strongly associated with mortality. Acute respiratory distress syndrome is also strongly associated with mortality. Conclusions and Relevance: Coronavirus disease 2019 is associated with a high inflammatory burden that can induce vascular inflammation, myocarditis, and cardiac arrhythmias. Extensive efforts are underway to find specific vaccines and antivirals against SARS-CoV-2. Meanwhile, cardiovascular risk factors and conditions should be judiciously controlled per evidence-based guidelines.. © 2020 Cambridge University Press. 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(2004) Tex Heart Inst J, 31 (1), pp. 4-13. , PMID 15061620; Corrales-Medina, V.F., Madjid, M., Musher, D.M., Role of acute infection in triggering acute coronary syndromes (2010) Lancet Infect Dis, 10 (2), pp. 83-92. , http://dx.doi.org/10.1016/S1473-3099(09)70331-7, doi: PMID 20113977; Madjid, M., Casscells, S.W., Of birds and men: Cardiologists' role in influenza pandemics (2004) Lancet, 364 (9442), p. 1309. , http://dx.doi.org/10.1016/S0140-6736(04)17176-6, doi: PMID 15474125; Wu, Z., McGoogan, J.M., Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention (2020) JAMA, , http://jamanetwork.com/article.aspx?doi=10.1001/jama.2020.2648, doi: PMID 32091533; Wang, M., Cao, R., Zhang, L., Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro (2020) Cell Res, 30 (3), pp. 269-271. , http://dx.doi.org/10.1038/s41422-020-0282-0, doi: PMID 32020029; Gautret, P., Lagier, J.-C., Parola, P., Hydroxychloroquine and azithromycin as a treatment of COVID-19: Results of an open-label non-randomized clinical trial (2020) Int J Antimicrob Agents, , http://dx.doi.org/10.1016/j.ijantimicag.2020.105949; Gao, J., Tian, Z., Yang, X., Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies (2020) Biosci Trends, 14 (1), pp. 72-73. , http://dx.doi.org/10.5582/bst.2020.01047, doi: PMID 32074550; Cao, B., Wang, Y., Wen, D., A trial of lopinavir-ritonavir in adults hospitalized with severe COVID-19 (2020) N Engl J Med, , http://dx.doi.org/10.1056/NEJMoa2001282, doi: PMID 32187464; HFSA/ACC/AHA Statement Addresses Concerns Re: Using RAAS Antagonists in COVID-19, , https://professional.heart.org/professional/ScienceNews/UCM_505836_HFSAACCAHA-statement-addresses-concerns-re-using-RAAS-antagonists-in-COVID-19.jsp, Accessed March 19, 2020; Hoffmann, M., Kleine-Weber, H., Schroeder, S., SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor (2020) Cell, , http://dx.doi.org/10.1016/j.cell.2020.02.052, S0092-8674(20)30229-4. doi: PMID 32142651; (2019) Coronavirus Disease (COVID-19), , https://www.cdc.gov/coronavirus/2019-ncov/index.html, Accessed March 19, 2020","Madjid, M.; McGovern Medical School, Department of Medicine, University of Texas Health Science Center at Houston, 6431 Fannin, MSB 1.246, United States; email: mmadjid@gmail.com",,American Medical Association,23806583,,,32219363,English,JAMA Cardiol.,Review,Article in Press,Open Access,Scopus,2-s2.0-85082446589,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Whittaker G.R., Millet J.K.",7006825143;55217392700;,Biochemical characterization of middle east respiratory syndrome coronavirus spike protein proteolytic processing,2020,Methods in Molecular Biology,2099,,,21,37,,,10.1007/978-1-0716-0211-9_3,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077313219&doi=10.1007%2f978-1-0716-0211-9_3&partnerID=40&md5=28cf22ebf471f9925a58f4fcdb273960,"Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, United States; Virologie et Immunologie Moléculaires, INRA, Jouy-en-Josas, France","Whittaker, G.R., Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, United States; Millet, J.K., Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY, United States, Virologie et Immunologie Moléculaires, INRA, Jouy-en-Josas, France","The coronavirus spike envelope glycoprotein is an essential viral component that mediates virus entry events. Biochemical assessment of the spike protein is critical for understanding structure–function relationships and the roles of the protein in the viral life cycle. Coronavirus spike proteins are typically proteolytically processed and activated by host cell enzymes such as trypsin-like proteases, cathepsins, or proprotein-convertases. Analysis of coronavirus spike proteins by western blot allows the visualization and assessment of proteolytic processing by endogenous or exogenous proteases. Here, we present a method based on western blot analysis to investigate spike protein proteolytic cleavage by transient transfection of HEK-293 T cells allowing expression of the spike protein of the highly pathogenic Middle East respiratory syndrome coronavirus in the presence or absence of a cellular trypsin-like transmembrane serine protease, matriptase. Such analysis enables the characterization of cleavage patterns produced by a host protease on a coronavirus spike glycoprotein. © Springer Science+Business Media, LLC, part of Springer Nature 2020.",Coronavirus; Host cell protease; Matriptase; Middle East respiratory syndrome (MERS); Proteolytic processing; Spike protein; Transient transfection; Virus entry; Western blot,,"Fehr, A.R., Perlman, S., Coronaviruses: An overview of their replication and pathogenesis (2015) Methods Mol Biol, 1282, pp. 1-23; Bosch, B.J., Rottier, P., (2008) Nidovirus Entry into Cells, pp. 157-178. , Perlman S, Gallagher T, Snijder EJ (eds) Nidoviruses. ASM Press, Washington, DC; Bosch, B.J., van der Zee, R., de Haan, C.A.M., Rottier, P.J.M., The coronavirus spike protein is a class I virus fusion protein: Structural and functional characterization of the fusion Core complex (2003) J Virol, 77 (16), pp. 8801-8811; White, J.M., Delos, S.E., Brecher, M., Schornberg, K., Structures and mechanisms of viral membrane fusion proteins: Multiple variations on a common theme (2008) Crit Rev Biochem Mol Biol, 43 (3), pp. 189-219; Belouzard, S., Chu, V.C., Whittaker, G.R., Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites (2009) Proc Natl Acad Sci, 106 (14), pp. 5871-5876; Millet, J.K., Whittaker, G.R., Host cell proteases: Critical determinants of coronavirus tropism and pathogenesis (2015) Virus Res, 202, pp. 120-134; White, J.M., Whittaker, G.R., Fusion of enveloped viruses in endosomes (2016) Traffic, 17 (6), pp. 593-614; Park, J.E., Proteolytic processing of Middle East respiratory syndrome coronavirus spikes expands virus tropism (2016) Proc Natl Acad Sci U S A, 113 (43), pp. 12262-12267; Lazarowitz, S.G., Choppin, P.W., Enhancement of the infectivity of influenza a and B viruses by proteolytic cleavage of the hemagglutinin polypeptide (1975) Virology, 68 (2), pp. 440-454; Lazarowitz, S.G., Compans, R.W., Choppin, P.W., Proteolytic cleavage of the hemagglutinin polypeptide of influenza virus. Function of the uncleaved polypeptide HA (1973) Virology, 52 (1), pp. 199-212; Klenk, H.D., Matrosovich, M., Stech, J., Avian influenza: Molecular Mechansims of pathogenesis (2008) Animal Viruses: Molecular Biology, pp. 253-303. , Mettenleiter T, Sobrino F, Cais-ter Academic Press, Norfolk, UK; Gierer, S., The spike-protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2 and is targeted by neutralizing antibodies (2013) J Virol, 87 (10), pp. 5502-5511; Qian, Z., Dominguez, S.R., Holmes, K.V., Role of the spike glycoprotein of human Middle East respiratory syndrome coronavirus (MERS-CoV) in virus entry and syncytia formation (2013) Plos One, 8 (10); Shirato, K., Kawase, M., Matsuyama, S., Middle East respiratory syndrome coronavirus (MERS-CoV) infection mediated by the Trans-membrane serine protease TMPRSS2 (2013) J Virol, 87 (23), pp. 12552-12561; Kawase, M., Shirato, K., van der Hoek, L., Taguchi, F., Matsuyama, S., Simultaneous treatment of human bronchial epithelial cells with serine and cysteine protease inhibitors prevents severe acute respiratory syndrome coronavirus entry (2012) J Virol, 86 (12), pp. 6537-6545; Burkard, C., Coronavirus cell entry occurs through the Endo‒/Lysosomal pathway in a proteolysis-dependent manner (2014) Plos Pathog, 10 (11); Millet, J.K., Whittaker, G.R., Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein (2014) Proc Natl Acad Sci, 111 (42), pp. 15214-15219; Matsuyama, S., Middle East respiratory syndrome coronavirus spike protein is not activated directly by cellular Furin during viral entry into target cells (2018) J Virol, 92 (19), p. e00683; Kleine-Weber, H., Elzayat, M.T., Hoffmann, M., Pöhlmann, S., Functional analysis of potential cleavage sites in the MERS-coronavirus spike protein (2018) Sci Rep, 8 (1); Oberst, M.D., Characterization of matriptase expression in normal human tissues (2003) J Histochem Cytochem, 51 (8), pp. 1017-1025; Shimomura, T., Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor (1997) J Biol Chem, 272 (10), pp. 6370-6376; Beaulieu, A., Matriptase proteolytically activates influenza virus and promotes multicycle replication in the human airway epithelium (2013) J Virol, 87 (8), pp. 4237-4251; Hamilton, B.S., Gludish, D.W., Whittaker, G.R., Cleavage activation of the human-adapted influenza virus subtypes by Matriptase reveals both subtype and strain specificities (2012) J Virol, 86 (19), pp. 10579-10586; Wicht, O., Identification and characterization of a Proteolytically primed form of the murine coronavirus spike proteins after fusion with the target cell (2014) J Virol, 88 (9), pp. 4943-4952; Millet, J.K., A camel-derived MERS-CoV with a variant spike protein cleavage site and distinct fusion activation properties (2016) Emerg Microbes Infect, 5 (12), p. e126","Millet, J.K.; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell UniversityUnited States; email: jean.millet@inra.fr",,Humana Press Inc.,10643745,,,31883085,English,Methods Mol. Biol.,Book Chapter,Final,Open Access,Scopus,2-s2.0-85077313219,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Xu L., Liu J., Lu M., Yang D., Zheng X.",57216042390;57196292096;57215853909;57215852525;36766091000;,Liver injury during highly pathogenic human coronavirus infections,2020,Liver International,,,,,,,,10.1111/liv.14435,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082532828&doi=10.1111%2fliv.14435&partnerID=40&md5=4efa3159d848b273f76466a7d1bd5bae,"Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Joint International Laboratory of Infection and Immunity, Huazhong University of Science and Technology, Wuhan, China; Institute for Virology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany","Xu, L., Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, Joint International Laboratory of Infection and Immunity, Huazhong University of Science and Technology, Wuhan, China; Liu, J., Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, Joint International Laboratory of Infection and Immunity, Huazhong University of Science and Technology, Wuhan, China; Lu, M., Joint International Laboratory of Infection and Immunity, Huazhong University of Science and Technology, Wuhan, China, Institute for Virology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany; Yang, D., Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, Joint International Laboratory of Infection and Immunity, Huazhong University of Science and Technology, Wuhan, China; Zheng, X., Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, Joint International Laboratory of Infection and Immunity, Huazhong University of Science and Technology, Wuhan, China","The severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), the pathogen of 2019 novel coronavirus disease (COVID-19), has posed a serious threat to global public health. The WHO has declared the outbreak of SARS-CoV-2 infection an international public health emergency. Lung lesions have been considered as the major damage caused by SARS-CoV-2 infection. However, liver injury has also been reported to occur during the course of the disease in severe cases. Similarly, previous studies have shown that liver damage was common in the patients infected by the other two highly pathogenic coronavirus – severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV), and associated with the severity of diseases. In this review, the characteristics and mechanism of liver injury caused by SARS-CoV, MERS-CoV as well as SARS-CoV-2 infection were summarized, which may provide help for further studies on the liver injury of COVID-19. © 2020 John Wiley & Sons A/S. 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A first step in understanding SARS pathogenesis (2004) J Patho, 203 (2), pp. 631-637; Tan, Y.-J., Fielding, B.C., Goh, P.-Y., Overexpression of 7a, a protein specifically encoded by the severe acute respiratory syndrome coronavirus, induces apoptosis via a caspase-dependent pathway (2004) J Virol, 78 (24), pp. 14043-14047; Yang, Z., Xu, M., Yi, J.Q., Clinical characteristics and mechanism of liver damage in patients with severe acute respiratory syndrome (2005) Hepatobiliary Pancreat Dis Int, 4 (1), pp. 60-63; Zumla, A., Hui, D.S., Perlman, S., Middle East respiratory syndrome (2015) Lancet, 386 (9997), pp. 995-1007; Saad, M., Omrani, A.S., Baig, K., Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia (2014) Int J Infect Dis, 29, pp. 301-306; Al-Hameed, F., Wahla, A.S., Siddiqui, S., Characteristics and outcomes of Middle East respiratory syndrome coronavirus patients admitted to an intensive care unit in Jeddah, Saudi Arabia (2015) J Intensive Care Med, 31 (5), pp. 344-348; Hwang, S.-M., Na, B.-J., Jung, Y., Clinical and laboratory findings of Middle East respiratory syndrome coronavirus infection (2019) Jap J Infect Dis, 72 (3), pp. 160-167; Arabi, Y.M., Al-Omari, A., Mandourah, Y., Critically Ill patients with the Middle East respiratory syndrome (2017) Crit Care Med, 45 (10), pp. 1683-1695; Arabi, Y.M., Arifi, A.A., Balkhy, H.H., Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection (2014) Ann Intern Med, 160 (6), pp. 389-397; Assiri, A., Al-Tawfiq, J.A., Al-Rabeeah, A.A., Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study (2013) Lancet Infect Dis, 13 (9), pp. 752-761; Ng, D.L., Al Hosani, F., Keating, M.K., Clinicopathologic, immunohistochemical, and ultrastructural findings of a fatal case of Middle East respiratory syndrome coronavirus infection in the United Arab Emirates, April 2014 (2016) Am J Patho, 186 (3), pp. 652-658; 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Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395 (10223), pp. 497-506; Guan, W., Ni, Z., Hu, Y., Clinical characteristics of 2019 novel coronavirus infection in China (2020) medRxiv, , https://doi.org/10.1101/2020.02.06.20020974, in press; Cai, Q., Huang, D., Ou, P., COVID-19 in a Designated Infectious Diseases HospitalOutside Hubei Province, China (2020) medRxiv, , https://doi.org/10.1101/2020.02.17.20024018, in press; Fan, Z., Chen, L., Jun, L.I., Clinical features of COVID-19-related liver damage (2020) medRxiv, , https://doi.org/10.1101/2020.02.26.20026971, in press; Wang, D., Hu, B.O., Hu, C., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) JAMA; Cao, W., Clinical features and laboratory inspection of novel coronavirus pneumonia (COVID-19) in Xiangyang, Hubei (2020) medRxiv, , https://doi.org/10.1101/2020.02.23.20026963, in press; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395 (10223), pp. 507-513; Shi, H., Han, X., Jiang, N., Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study (2020) Lancet Infect Dis, , https://doi.org/10.1016/S1473-3099(20)30086-4; Xu, X.-W., Wu, X.-X., Jiang, X.-G., Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series (2020) BMJ, p. m606; Yang, X., Yu, Y., Xu, J., Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study (2020) Lancet Respir Med, , https://doi.org/10.1016/S2213-2600(20)30079-5; Zhang, B., Zhou, X., Qiu, Y., Clinical characteristics of 82 death cases with COVID-19 (2020) medRxiv, , https://doi.org/10.1101/2020.02.26.20028191, in press; Huang, Y., Zhou, H., Yang, R., Clinical characteristics of 36 non-survivors with COVID-19 in Wuhan, China (2020) medRxiv, , https://doi.org/10.1101/2020.02.27.20029009, in press; Hoffmann, M., Kleine-Weber, H., Krüger, N., The novel coronavirus 2019 (2019-nCoV) uses the SARS-1 coronavirus receptor2 ACE2 and the cellular protease TMPRSS2 for entry into target cells (2020) bioRxiv, , https://doi.org/10.1101/2020.01.31.929042, in press; Chai, X., Hu, L., Zhang, Y., Specific ACE2 expression in cholangiocytes may cause liver damage after 2019-nCoV infection (2020) bioRxiv, , https://doi.org/10.1101/2020.02.03.931766; Banales, J.M., Huebert, R.C., Karlsen, T., Strazzabosco, M., LaRusso, N.F., Gores, G.J., Cholangiocyte pathobiology (2019) Nat Rev Gastroenterol Hepatol, 16 (5), pp. 269-281; Liu, J., Li, S., Liu, J., Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients (2020) medRxiv, , https://doi.org/10.1101/2020.02.16.20023671, in press; Xu, Z., Shi, L., Wang, Y., Pathological findings of COVID-19 associated with acute respiratory distress syndrome (2020) Lancet Respir Med, , https://doi.org/10.1016/S2213-2600(20)30076-X; Diagnosis and Treatment of Coronavirus disease 2019 (Trial Version 7), , http://www.nhc.gov.cn/yzygj/s7652m/202003/a31191442e29474b98bfed5579d5af95.shtml, Accessed March 6, 2020; Yu, C., Mao, Y., Guidelines for the management of drug-induced liver injury (2017) J Prac Hepatol, 20 (2), pp. 257-274; Guan, Y., Zheng, B.J., He, Y.Q., Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China (2003) Science, 302 (5643), pp. 276-278; (2020) Severe Acute Respiratory Syndrome (SARS), , http://www.who.int/csr/sars/en/, Accessed Feburary 24, 2020; Middle East respiratory syndrome coronavirus (MERS-CoV), , .https://www.who.int/emergencies/mers-cov/en/, Accessed Feburary 24, 2020; Xiao, K., Zhai, J., Feng, Y., Isolation and characterization of 2019-nCoV-like coronavirus from Malayan pangolins (2020) bioRxiv, , https://doi.org/10.1101/2020.02.17.951335","Zheng, X.; Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyChina; email: xin11@hotmail.com",,Blackwell Publishing Ltd,14783223,,LIINC,32170806,English,Liver Int.,Review,Article in Press,Open Access,Scopus,2-s2.0-85082532828,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "He H., Zhao S., Han L., Wang Q., Xia H., Huang X., Yao S., Huang J., Chen X.",57205374348;57215769778;57214825040;57215928300;57210785467;57207926578;7402472375;23110843500;56440360700;,Anesthetic Management of Patients Undergoing Aortic Dissection Repair With Suspected Severe Acute Respiratory Syndrome Coronavirus-2 Infection,2020,Journal of Cardiothoracic and Vascular Anesthesia,,,,,,,,10.1053/j.jvca.2020.03.021,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082472987&doi=10.1053%2fj.jvca.2020.03.021&partnerID=40&md5=0d0b9e7902d9bc590e3616ef028b0100,"Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Department of Anesthesiology and Perioperative Medicine, University of LouisvilleKY, United States","He, H., Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Zhao, S., Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Han, L., Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Wang, Q., Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Xia, H., Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Huang, X., Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Yao, S., Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Huang, J., Department of Anesthesiology and Perioperative Medicine, University of LouisvilleKY, United States; Chen, X., Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China","Severe acute respiratory syndrome coronavirus-2 is still active in Wuhan, China, and is spreading to the rest of the world. Recently, perioperative anesthetic management in patients with suspected or confirmed coronavirus-2 has been reported. However, little has been reported on the anesthetic management of patients undergoing aortic dissection repair in patients with suspected severe acute respiratory syndrome coronavirus-2 infection. During the outbreak in Wuhan, the authors’ team completed 4 cases of aortic dissection repair successfully in patients with suspected severe acute respiratory syndrome coronavirus-2 infection. The purpose of the present report is to summarize current knowledge and experiences on anesthetic management in this patient population and to provide clinical practice guidelines on anesthetic management and infection prevention and control in these critically ill patients. © 2020 Elsevier Inc.",anesthetic management; aortic dissection; COVID-19; infection control; SARS-CoV-2,,"December, I., A novel coronavirus outbreak of global health concern (2020) Lancet, 6736, pp. 1-4; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 6736, pp. 1-10; Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med United States, 382, pp. 727-733; (2020), http://www.chinacdc.cn/jkzt/crb/zl/szkb_11803/, Chinese Center for Disease Control and Prevention. Available at: Accessed March 9; World Health Organization, (2020), https://www.who.int/emergencies/diseases/novel-coronavirus-2019, Coronavirus disease (COVID-19) outbreak. Available at: Accessed March 9; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study (2020) Lancet, 6736, pp. 1-7; de Groot, R.J., Baker, S.C., Baric, R.S., Middle East respiratory syndrome coronavirus (MERS-CoV): Announcement of the Coronavirus Study Group (2013) J Virol, 87, pp. 7790-7792; De Wit, E., Van Doremalen, N., Falzarano, D., SARS and MERS: Recent insights into emerging coronaviruses (2016) Nat Rev Microbiol, 14, pp. 523-534; Drosten, C., Gunther, S., Preiser, W., Identification of a novel coronavirus in patients with severe acute respiratory syndrome (2003) N Engl J Med, 348, pp. 1967-1976; Fuk-Woo Chan, J., Yuan, S., Kok, K.-H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: A study of a family cluster (2020) Lancet, 6736, pp. 1-10; Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia [E-pub ahead of print]. N Engl J Med. doi:; Wang, D., Hu, B., Hu, C., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China [E-pub ahead of print]. JAMA. doi:; Chen, X., Shang, Y., Yao, S., Perioperative care provider's considerations in managing patients with the COVID-19 infections (2020) Transl Perioper Pain Med, 7, pp. 216-224; Mussa, F.F., Horton, J.D., Moridzadeh, R., Acute aortic dissection and intramural hematoma: A systematic review (2016) JAMA, 316, pp. 754-763; Lu, C., Liu, X., Jia, Z., 2019-nCoV transmission through the ocular surface must not be ignored (2020) Lancet, 6736, p. 30313; Holshue, M.L., DeBolt, C., Lindquist, S., First case of 2019 novel coronavirus in the United States (2020) N Engl J Med, 382, pp. 929-936","Huang, J.; Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyChina",,W.B. Saunders,10530770,,JCVAE,,English,J. Cardiothorac. Vasc. Anesth.,Article,Article in Press,Open Access,Scopus,2-s2.0-85082472987,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Sorbello M., El-Boghdadly K., Di Giacinto I., Cataldo R., Esposito C., Falcetta S., Merli G., Cortese G., Corso R.M., Bressan F., Pintaudi S., Greif R., Donati A., Petrini F., The Societa Italiana di Anestesia Analgesia Rianimazione e Terapia Intensiva (SIAARTI) Airway Research Group, and The European Airway Management Society",13805848700;54966702900;8684750600;7005484908;57104649800;6503957838;57197606930;57200863789;14029670400;57215962981;55936556600;25651608800;17933810500;7003626213;,The Italian coronavirus disease 2019 outbreak: recommendations from clinical practice,2020,Anaesthesia,,,,,,,,10.1111/anae.15049,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082436952&doi=10.1111%2fanae.15049&partnerID=40&md5=feeb1e781063bee7198eca52a5605d31,"Anesthesia and Intensive Care, AOU Policlinico San Marco University HospitalCatania, Italy; Department of Anaesthesia, Guy's and St Thomas’ NHS Foundation Trust, London, United Kingdom; Anesthesia and Intensive Care, Anestesia e Terapia Intensiva Polivalente, Azienda Ospedaliero Universitaria Sant'Orsola-Malpighi - Alma Mater Studiorum, Bologna, Italy; Anesthesia and Intensive Care, Anestesia, Terapia Intensiva e Terapia del Dolore, Università Campus, Bio-Medico, Roma, Italy; Anesthesia and Intensive Care, Dipartimento di Area Critica Ospedale Monaldi, Ospedali dei Colli, Napoli, Italy; Anesthesia and Intensive Care, Clinica di Anestesia e Rianimazione Ospedali Riuniti Ancona, Ancona, Italy; Anesthesia and Intensive Care, Dipartimento di Anestesia e Terapia Intensiva, Ospedale Maggiore Crema, Milano, Italy; Anesthesia and Intensive Care, Dipartimento di Anestesia, Rianimazione ed Emergenze AOU Città della salute e della scienza Torino, Italy; Anesthesia and Intensive Care, Dipartimento di Chirurgia, Anestesia e Rianimazione, Ospedale GB Morgagni-L. Pierantoni, Forlì, Italy; Anesthesia and Intensive Care, Anestesia e Rianimazione Ospedale Santo Stefano di Prato, Prato, Italy; Anesthesia and Intensive Care, Past Head of Dipartimento di Emergenza, ARNAS Garibaldi Catania, Past Bio-containment coordinator for Sicily, Italian Military Navy scientific consultant, Italy; Department of Anaesthesiology and Pain Therapy, Bern University Hospital, University of Bern, Switzerland; Università Politecnica delle Marche, Ancona, Italy; Anesthesia and Intensive Care Dipartimento di Medicina Perioperatoria, Dolore, Terapia Intensiva e Rapid Response System, Ospedale di Chieti, Università di Chieti Pescara, Chieti, Italy","Sorbello, M., Anesthesia and Intensive Care, AOU Policlinico San Marco University HospitalCatania, Italy; El-Boghdadly, K., Department of Anaesthesia, Guy's and St Thomas’ NHS Foundation Trust, London, United Kingdom; Di Giacinto, I., Anesthesia and Intensive Care, Anestesia e Terapia Intensiva Polivalente, Azienda Ospedaliero Universitaria Sant'Orsola-Malpighi - Alma Mater Studiorum, Bologna, Italy; Cataldo, R., Anesthesia and Intensive Care, Anestesia, Terapia Intensiva e Terapia del Dolore, Università Campus, Bio-Medico, Roma, Italy; Esposito, C., Anesthesia and Intensive Care, Dipartimento di Area Critica Ospedale Monaldi, Ospedali dei Colli, Napoli, Italy; Falcetta, S., Anesthesia and Intensive Care, Clinica di Anestesia e Rianimazione Ospedali Riuniti Ancona, Ancona, Italy; Merli, G., Anesthesia and Intensive Care, Dipartimento di Anestesia e Terapia Intensiva, Ospedale Maggiore Crema, Milano, Italy; Cortese, G., Anesthesia and Intensive Care, Dipartimento di Anestesia, Rianimazione ed Emergenze AOU Città della salute e della scienza Torino, Italy; Corso, R.M., Anesthesia and Intensive Care, Dipartimento di Chirurgia, Anestesia e Rianimazione, Ospedale GB Morgagni-L. Pierantoni, Forlì, Italy; Bressan, F., Anesthesia and Intensive Care, Anestesia e Rianimazione Ospedale Santo Stefano di Prato, Prato, Italy; Pintaudi, S., Anesthesia and Intensive Care, Past Head of Dipartimento di Emergenza, ARNAS Garibaldi Catania, Past Bio-containment coordinator for Sicily, Italian Military Navy scientific consultant, Italy; Greif, R., Department of Anaesthesiology and Pain Therapy, Bern University Hospital, University of Bern, Switzerland; Donati, A., Università Politecnica delle Marche, Ancona, Italy; Petrini, F., Anesthesia and Intensive Care Dipartimento di Medicina Perioperatoria, Dolore, Terapia Intensiva e Rapid Response System, Ospedale di Chieti, Università di Chieti Pescara, Chieti, Italy; The Societa Italiana di Anestesia Analgesia Rianimazione e Terapia Intensiva (SIAARTI) Airway Research Group, and The European Airway Management Society","Novel coronavirus 2019 is a single-stranded, ribonucleic acid virus that has led to an international pandemic of coronavirus disease 2019. Clinical data from the Chinese outbreak have been reported, but experiences and recommendations from clinical practice during the Italian outbreak have not. We report the impact of the coronavirus disease 2019 outbreak on regional and national healthcare infrastructure. We also report on recommendations based on clinical experiences of managing patients throughout Italy. In particular, we describe key elements of clinical management, including: safe oxygen therapy; airway management; personal protective equipment; and non-technical aspects of caring for patients diagnosed with coronavirus disease 2019. Only through planning, training and team working will clinicians and healthcare systems be best placed to deal with the many complex implications of this new pandemic. © 2020 Association of Anaesthetists",COVID-19; critical care; tracheal intubation; ventilation,,"Livingston, E., Bucher, K., Rekito, A., Coronavirus disease 2019 and influenza (2020) Journal of the American Medical Association, , https://doi.org/10.1001/jama.2020.2633, [Epub ahead of print]; Wang, C., Horby, P.W., Hayden, F.G., Gao, G.F., A novel coronavirus outbreak of global health concern (2020) Lancet, 395, pp. 470-473; Peng, P.W.H., Ho, P., Hota, S.S., Outbreak of a new coronavirus: what anaesthetists should know (2020) British Journal of Anaesthesia, 395, pp. 470-473. , https://doi.org/10.1016/S0140-6736(20)30185-9; (2020) Coronavirus, , https://www.cdc.gov/coronavirus/about/index.html, (accessed 28/02/2020); Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506; Fauci, A.S., Lane, H.C., Redfield, R.R., COVID-19 - Navigating the Uncharted (2020) New England Journal of Medicine, , https://doi.org/10.1056/NEJMe2002387, [Epub ahead of print]; Zou, L., Ruan, F., Huang, M., SARS-CoV-2 viral load in upper respiratory specimens of infected patients (2020) New England Journal of Medicine, 382, pp. 1177-1179. , https://doi.org/10.1056/NEJMc2001737; (2020), https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports, (accessed 19/03/2020); Summary of probable SARS cases with onset of illness from 1 November 2002 to 31 July 2003, , https://www.who.int/csr/sars/country/table, Based on data as of the 31 December 2003., 2004_04_21/en (accessed 04/03/2020); Paules, C.I., Marston, H.D., Fauci, A.S., Coronavirus infections-more than just the common cold (2020) Journal of the American Medical Association, , https://doi.org/10.1001/jama.2020.0757, [Epub ahead of print]; Phelan, A.L., Katz, R., Gostin, L.O., The novel coronavirus originating in Wuhan, China: challenges for global health governance (2020) Journal of the American Medical Association, , https://doi.org/10.1001/jama.2020.1097, [Epub ahead of print]; Qiu, H., Tong, Z., Ma, P., Intensive care during the coronavirus epidemic (2020) Intensive Care Medicine, , https://doi.org/10.1007/s00134-020-05966-y, [Epub ahead of print]; Bouadma, L., Lescure, F.X., Lucet, J.C., Severe SARS-CoV-2 infections: practical considerations and management strategy for intensivists (2020) Intensive Care Medicine, , https://doi.org/10.1007/s00134-020-05967-x, [Epub ahead of print]; (2020) Coronavirus (COVID-19) Mortality Rate, , https://www.worldometers.info/coronavirus/coronavirus-death-rate, (accessed 02/03/2020); (2020) Daily update of covid19 outbreak from Protezione Civile, , http://opendatadpc.maps.arcgis.com/apps/opsdashboard/index.html#/b0c68bce2cce478eaac82fe38d4138b1, [Italian], (accessed 07/03/2020); https://www.gazzettaufficiale.it/eli/id/2020/03/04/20A01475/sg, (accessed 05/032020); (2020) Rational use of personal protective equipmentfor coronavirus disease 2019 (COVID-19), , https://apps.who.int/iris/bitstream/handle/10665/331215/WHO-2019-nCov-IPCPPE_use-2020.1-eng.pdf, (accessed 07/03/2020); Rhodes, A., Ferdinande, P., Flaatten, H., The variability of critical care bed numbers in Europe (2012) Intensive Care Medicine, 38, pp. 1647-1653; (2020) Coronavirus: northern Italy quarantines 16 million people, , https://www.bbc.co.uk/news/world-middle-east-51787238, (accessed 09/03/2020); (2020) Coronavirus, Giuseppe Conte: ecco il decreto ‘Io resto a casa’. 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A paradigm shift in airway management: implications for guidelines, clinical practice and teaching (2018) European Journal of Anaesthesiology, 35, pp. 811-814; Petrini, F., Accorsi, A., Adrario, E., Recommendations for airway control and difficult airway management (2005) Minerva Anestesiologica, 71, pp. 617-657; Ahmad, I., El-Boghdadly, K., Bhagrath, R., Difficult Airway Society guidelines for awake tracheal intubation (ATI) in adults (2020) Anaesthesia, 75, pp. 509-528; Nimmagadda, U., Salem, M.R., Crystal, G.J., Preoxygenation: physiologic basis, benefits, and potential risks (2017) Anesthesia and Analgesia, 124, pp. 507-517; Casey, J.D., Janz, D.R., Russell, D.W., Bag-mask ventilation during tracheal intubation of critically ill adults (2019) New England Journal of Medicine, 380, pp. 811-882; Sorbello, M., Aristotle, Galileo and Sellick: the unsolved dilemma of cricoid pressure (2016) Trends in Anaesthesia and Critical Care, 6, pp. 1-2; Birenbaum, A., Hajage, D., Roche, S., Effect of cricoid pressure compared with a sham procedure in the rapid sequence induction of anesthesia: the IRIS randomized clinical trial (2019) Journal of the American Medical Association: Surgery, 154, pp. 9-17; Oliveira, J.E., Silva, L., Cabrera, D., Effectiveness of apneic oxygenation during intubation: a systematic review and meta-analysis (2017) Annals of Emergency Medicine, 70, pp. 483.e11-94.e11; Mir, F., Patel, A., Iqbal, R., A randomised controlled trial comparing transnasal humidified rapid insufflation ventilatory exchange (THRIVE) pre-oxygenation with facemask pre-oxygenation in patients undergoing rapid sequence induction of anaesthesia (2017) Anaesthesia, 72, pp. 439-443; Lundstrom, L.H., Duez, C.H.V., Norskov, A.K., Avoidance of use of neuromuscular blocking agent for improving conditions during tracheal intubation: a Cochrane systematic review (2018) British Journal of Anaesthesia, 120, pp. 1381-1393; Driver, B.E., Prekker, M.E., Klein, L.R., Effect of use of a bougie vs endotracheal tube and stylet on first-attempt intubation success among patients with difficult airways undergoing emergency intubation: a randomized clinical trial (2018) Journal of the American Medical Association, 319, pp. 2179-2189; Sorbello, M., Cortese, G., Gaçonnet, C., Skinner, M., A modified Bailey's manoeuvre for supraglottic airway continuum using LMA Protector™ (2019) Indian Journal of Anaesthesia, 63, pp. 78-80; Solidoro, P., Corbetta, L., Patrucco, F., Competences in bronchoscopy for Intensive Care Unit, anesthesiology, thoracic surgery and lung transplantation (2019) Panminerva Medica, 61, pp. 367-385; Agrò, F.E., Cataldo, R., Teaching fiberoptic intubation in Italy: state of the art (2010) Minerva Anestesiologica, 76, pp. 684-685; Cabrini, L., Baiardo Redaelli, M., Ball, L., Awake fiberoptic intubation protocols in the operating room for anticipated difficult airway: a systematic review and meta-analysis of randomized controlled trials (2019) Anesthesia and Analgesia, 128, pp. 971-980; Mouritsen, J.M., Ehlers, L., Kovaleva, J., A systematic review and cost effectiveness analysis of reusable vs. single-use flexible bronchoscopes (2020) Anaesthesia, 75, pp. 529-540; Alhomary, M., Ramadan, E., Curran, E., Walsh, S.R., Videolaryngoscopy vs. fibreoptic bronchoscopy for awake tracheal intubation: a systematic review and meta-analysis (2018) Anaesthesia, 73, pp. 1151-1161; Sorbello, M., Frova, G., When the end is really the end? Extubation of the difficult airway (2013) Minerva Anestesiologica, 79, pp. 194-199; Kamming, D., Gardam, M., Chung, F., Anaesthesia and SARS (2003) British Journal of Anaesthesia, 90, pp. 715-718; Lowe, J.J., Jelden, K.C., Schenarts, P.J., Considerations for safe EMS transport of patients infected with Ebola virus (2015) Prehospital Emergency Care, 19, pp. 179-183; Jansson, M., Liao, X., Rello, J., Strengthening ICU health security for a coronavirus epidemic (2020) Intensive and Critical Care Nursing, 57, p. 102812. , https://doi.org/10.1016/j.iccn.2020.102812; Oglesby, K.J., Sterne, J.A.C., Gibbison, B., Improving early warning scores – more data, better validation, the same response (2020) Anaesthesia, 75, pp. 149-151; (2020) Epidemia COVID-19, , https://www.epicentro.iss.it/coronavirus/bollettino/Bollettino-sorveglianza-integrata-COVID-19_09-marzo-2020.pdf, (accessed 19/03/2020)","Sorbello, M.; Anesthesia and Intensive Care, AOU Policlinico San Marco University HospitalItaly; email: maxsorbello@gmail.com",,Blackwell Publishing Ltd,32409,,ANASA,,English,Anaesthesia,Article,Article in Press,Open Access,Scopus,2-s2.0-85082436952,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Fung S.-Y., Yuen K.-S., Ye Z.-W., Chan C.-P., Jin D.-Y.",56956400000;55588721400;56611152500;36193690700;7201973614;,A tug-of-war between severe acute respiratory syndrome coronavirus 2 and host antiviral defence: lessons from other pathogenic viruses,2020,Emerging Microbes and Infections,9,1,,558,570,,,10.1080/22221751.2020.1736644,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081911507&doi=10.1080%2f22221751.2020.1736644&partnerID=40&md5=1917008e6844d6744e2ac96cbeb70859,"School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong; Department of Microbiology, The University of Hong Kong, Pokfulam, Hong Kong","Fung, S.-Y., School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong; Yuen, K.-S., School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong; Ye, Z.-W., Department of Microbiology, The University of Hong Kong, Pokfulam, Hong Kong; Chan, C.-P., School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong; Jin, D.-Y., School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong","World Health Organization has declared the ongoing outbreak of coronavirus disease 2019 (COVID-19) a Public Health Emergency of International Concern. The virus was named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by the International Committee on Taxonomy of Viruses. Human infection with SARS-CoV-2 leads to a wide range of clinical manifestations ranging from asymptomatic, mild, moderate to severe. The severe cases present with pneumonia, which can progress to acute respiratory distress syndrome. The outbreak provides an opportunity for real-time tracking of an animal coronavirus that has just crossed species barrier to infect humans. The outcome of SARS-CoV-2 infection is largely determined by virus-host interaction. Here, we review the discovery, zoonotic origin, animal hosts, transmissibility and pathogenicity of SARS-CoV-2 in relation to its interplay with host antiviral defense. A comparison with SARS-CoV, Middle East respiratory syndrome coronavirus, community-acquired human coronaviruses and other pathogenic viruses including human immunodeficiency viruses is made. We summarize current understanding of the induction of a proinflammatory cytokine storm by other highly pathogenic human coronaviruses, their adaptation to humans and their usurpation of the cell death programmes. Important questions concerning the interaction between SARS-CoV-2 and host antiviral defence, including asymptomatic and presymptomatic virus shedding, are also discussed. © 2020, © 2020 The Author(s). 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Buffalo, C.Z., Stürzel, C.M., Heusinger, E., Structural basis for tetherin antagonism as a barrier to zoonotic lentiviral transmission (2019) Cell Host Microbe, 26, pp. 359-368; Chan, C.P., Kok, K.H., Jin, D.Y., Human T-cell leukemia virus type 1 infection and adult T-cell leukemia (2017) Adv Exp Med Biol, 1018, pp. 147-166; Mahieux, R., Gessain, A., HTLV-3/STLV-3 and HTLV-4 viruses: discovery, epidemiology, serology and molecular aspects (2011) Viruses, 3, pp. 10740-10790; Chan, J.F., Kok, K.H., Zhu, Z., Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan (2020) Emerg Microbes Infect, 9, pp. 221-236; Wong, L.Y., Lui, P.Y., Jin, D.Y., A molecular arms race between host innate antiviral response and emerging human coronaviruses (2016) Virol Sin, 31, pp. 12-23; Shi, C.S., Nabar, N.R., Huang, N.N., SARS-Coronavirus open reading frame-8b triggers intracellular stress pathways and activates NLRP3 inflammasomes (2019) Cell Death Discov, 5, p. 101; Chan, J.F., Yuan, S., Kok, K.H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, 395, pp. 513-524; Shen, Z., Ning, F., Zhou, W., Superspreading SARS events, Beijing, 2003 (2004) Emerg Infect Dis, 10, pp. 256-260; Holshue, M.L., DeBolt, C., Lindquist, S., First case of 2019 novel coronavirus in the United States (2020) N Engl J Med, , https://doi.org/10.1056/NEJMoa2001191; Bai, Y., Yao, L., Wei, T., Presumed asymptomatic carrier transmission of COVID-19 (2020) JAMA, , https://doi.org/10.1001/jama.2020.1585; Heimdal, I., Moe, N., Krokstad, S., Human coronavirus in hospitalized children with respiratory tract infections: a 9-year population-based study from Norway (2019) J Infect Dis, 219, pp. 1198-1206; Lau, S.K., Feng, Y., Chen, H., Severe acute respiratory syndrome (SARS) coronavirus ORF8 protein is acquired from SARS-related coronavirus from greater horseshoe bats through recombination (2015) J Virol, 89, pp. 10532-10547; Huynh, J., Li, S., Yount, B., Evidence supporting a zoonotic origin of human coronavirus strain NL63 (2012) J Virol, 86, pp. 12816-12825; Higgins, P.G., Phillpotts, R.J., Scott, G.M., Intranasal interferon as protection against experimental respiratory coronavirus infection in volunteers (1983) Antimicrob Agents Chemother, 24, pp. 713-715; Mesel-Lemoine, M., Millet, J., Vidalain, P.O., A human coronavirus responsible for the common cold massively kills dendritic cells but not monocytes (2012) J Virol, 86, pp. 7577-7587; Siu, K.L., Yeung, M.L., Kok, K.H., Middle East respiratory syndrome coronavirus 4a protein is a double-stranded RNA-binding protein that suppresses PACT-induced activation of RIG-I and MDA5 in the innate antiviral response (2014) J Virol, 88, pp. 4866-4876; Siu, K.L., Kok, K.H., Ng, M.H., Severe acute respiratory syndrome coronavirus M protein inhibits type I interferon production by impeding the formation of TRAF3.TANK.TBK1/IKKε complex (2009) J Biol Chem, 284, pp. 16202-16209. , 1620; Lui, P.Y., Wong, L.Y., Fung, C.L., Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through the inhibition of TBK1-dependent phosphorylation of IRF3 (2016) Emerg Microbes Infect, 5, p. e39; Shen, Z., Wang, G., Yang, Y., A conserved region of nonstructural protein 1 from alphacoronaviruses inhibits host gene expression and is critical for viral virulence (2019) J Biol Chem, 294, pp. 13606-13618; Tohya, Y., Narayanan, K., Kamitani, W., Suppression of host gene expression by nsp1 proteins of group 2 bat coronaviruses (2009) J Virol, 83, pp. 5282-5288; Drappier, M., Michiels, T., Inhibition of the OAS/RNase L pathway by viruses (2015) Curr Opin Virol, 15, pp. 19-26; Forni, D., Cagliani, R., Clerici, M., Molecular evolution of human coronavirus genomes (2017) Trends Microbiol, 25, pp. 35-48; Thornbrough, J.M., Jha, B.K., Yount, B., Middle East respiratory syndrome coronavirus NS4b protein inhibits host RNase L activation (2016) mBio, 7, p. e00258; Danthi, P., Viruses and the diversity of cell death (2016) Annu Rev Virol, 3, pp. 533-553; Upton, J.W., Chan, F.K., Staying alive: cell death in antiviral immunity (2014) Mol Cell, 54, pp. 273-280; Richard, A., Tulasne, D., Caspase cleavage of viral proteins, another way for viruses to make the best of apoptosis (2012) Cell Death Dis, 3, p. e277; He, L., Ding, Y., Zhang, Q., Expression of elevated levels of pro-inflammatory cytokines in SARS-CoV-infected ACE2+ cells in SARS patients: relation to the acute lung injury and pathogenesis of SARS (2006) J Pathol, 210, pp. 288-297; Tang, B.S., Chan, K.H., Cheng, V.C., Comparative host gene transcription by microarray analysis early after infection of the Huh7 cell line by severe acute respiratory syndrome coronavirus and human coronavirus 229E (2005) J Virol, 79, pp. 6180-6193; Siu, K.L., Yuen, K.S., Castaño-Rodriguez, C., Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC (2019) FASEB J, 33, pp. 8865-8877; Nieto-Torres, J.L., DeDiego, M.L., Verdiá-Báguena, C., Severe acute respiratory syndrome coronavirus envelope protein ion channel activity promotes virus fitness and pathogenesis (2014) PLoS Pathog, 10, p. e1004077; DeDiego, M.L., Nieto-Torres, J.L., Regla-Nava, J.A., Inhibition of NF-κB-mediated inflammation in severe acute respiratory syndrome coronavirus-infected mice increases survival (2014) J Virol, 88, pp. 913-924; Nieto-Torres, J.L., Verdiá-Báguena, C., Jimenez-Guardeño, J.M., Severe acute respiratory syndrome coronavirus E protein transports calcium ions and activates the NLRP3 inflammasome (2015) Virology, 485, pp. 330-339; Chen, I.Y., Moriyama, M., Chang, M.F., Severe acute respiratory syndrome coronavirus viroporin 3a activates the NLRP3 inflammasome (2019) Front Microbiol, 10, p. 50; Chau, T.N., Lee, K.C., Yao, H., SARS-associated viral hepatitis caused by a novel coronavirus: report of three cases (2004) Hepatology, 39, pp. 302-310; Tan, Y.X., Tan, T.H., Lee, M.J., Induction of apoptosis by the severe acute respiratory syndrome coronavirus 7a protein is dependent on its interaction with the Bcl-XL protein (2007) J Virol, 81, pp. 6346-6355; Yue, Y., Nabar, N.R., Shi, C.S., SARS-coronavirus open reading frame-3a drives multimodal necrotic cell death (2018) Cell Death Dis, 9, p. 904","Jin, D.-Y.; School of Biomedical Sciences, 3/F Laboratory Block, 21 Sassoon Road, Hong Kong; email: dyjin@hku.hk",,Taylor and Francis Ltd.,22221751,,,32172672,English,Emerg. Microbes Infect.,Review,Final,Open Access,Scopus,2-s2.0-85081911507,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Meo S.A., Alhowikan A.M., Khlaiwi T.A.L., Meo I.M., Halepoto D.M., Iqbal M., Usmani A.M., Hajjar W., Ahmed N.",7003732623;57184248900;57215772330;23389862700;6505498897;57213578057;42062675300;35518559800;57209568184;,"Novel coronavirus 2019-nCoV: Prevalence, biological and clinical characteristics comparison with SARS-CoV and MERS-CoV",2020,European Review for Medical and Pharmacological Sciences,24,4,,2012,2019,,,10.26355/eurrev_202002_20379,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081531337&doi=10.26355%2feurrev_202002_20379&partnerID=40&md5=452a394abe8ce358d4bc16a5345cfbf9,"Department of Physiology, King Saud University, Riyadh, Saudi Arabia; Strategic Centre for Diabetes Research, King Saud University, Riyadh, Saudi Arabia; College of Medicine, King Saud University, Thoracic Surgery, Riyadh, Saudi Arabia; Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan","Meo, S.A., Department of Physiology, King Saud University, Riyadh, Saudi Arabia; Alhowikan, A.M., Department of Physiology, King Saud University, Riyadh, Saudi Arabia; Khlaiwi, T.A.L., Department of Physiology, King Saud University, Riyadh, Saudi Arabia; Meo, I.M., Department of Physiology, King Saud University, Riyadh, Saudi Arabia; Halepoto, D.M., Department of Physiology, King Saud University, Riyadh, Saudi Arabia; Iqbal, M., Department of Physiology, King Saud University, Riyadh, Saudi Arabia; Usmani, A.M., Strategic Centre for Diabetes Research, King Saud University, Riyadh, Saudi Arabia; Hajjar, W., College of Medicine, King Saud University, Thoracic Surgery, Riyadh, Saudi Arabia; Ahmed, N., Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan","OBJECTIVE: Human infections with zoonotic coronavirus contain emerging and reemerging pathogenic characteristics which have raised great public health concern. This study aimed at investigating the global prevalence, biological and clinical characteristics of novel coronavirus, Wuhan China (2019-nCoV), Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), and Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection outbreaks. MATERIALS AND METHODS: The data on the global outbreak of ""2019-nCoV, SARS-CoV, and MERS-CoV"" were obtained from World Health Organization (WHO), Centers for Disease Control and Prevention (CDC), concerned ministries and research institutes. We also recorded the information from research documents published in global scientific journals indexed in ISI Web of Science and research centers on the prevalence, biological and clinical characteristics of 2019-nCoV, SARS-CoV, and MERS-CoV. RESULTS: Worldwide, SARS-CoV involved 32 countries, with 8422 confirmed cases and 916 (10.87%) casualties from November 2002 to August 2003. MERS-CoV spread over 27 states, causing 2496 cases and 868 (34.77%) fatalities during the period April 2012 to December 2019. However, the novel coronavirus 2019-nCoV spread swiftly the global borders of 27 countries. It infected 34799 people and resulted in 724 (2.08%) casualties during the period December 29, 2019 to February 7, 2020. The fatality rate of coronavirus MERSCoV was (34.77%) higher than SARS-CoV (10.87%) and 2019-nCoV (2.08%); however, the 2019-nCoV transmitted rapidly in comparison to SARS-CoV and MERS-CoV. CONCLUSIONS: The novel coronavirus 2019-nCoV has diverse epidemiological and biological characteristics, making it more contagious than SARS-CoV and MERS-CoV. It has affected more people in a short time period compared to SARS-CoV and MERS-CoV, although the fatality rate of MERS-CoV was higher than SARS-CoV and 2019-nCoV. The major clinical manifestations in coronavirus infections 2019-nCoV, MERS-CoV, and SARS CoV are fever, chills, cough, shortness of breath, generalized myalgia, malaise, drowsy, diarrhea, confusion, dyspnea, and pneumonia. Global health authorities should take immediate measures to prevent the outbreaks of such emerging and reemerging pathogens across the globe to minimize the disease burden locally and globally. © 2020 Verduci Editore s.r.l. All rights reserved.",2019 ncov; Coronavirus; Mers cov; Outbreak; Prevalence; Sars cov,"2019 novel coronavirus; adult; aged; China; comparative study; Coronavirinae; Coronavirus infection; disease transmission; epidemic; female; human; human cell; major clinical study; male; middle aged; Middle East respiratory syndrome coronavirus; mortality rate; prevalence; public health service; Review; SARS coronavirus; Betacoronavirus; complication; Coronavirus infection; severe acute respiratory syndrome; virus pneumonia; COVID-19; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; Coronavirus Infections; Humans; Pneumonia, Viral; Prevalence; Severe Acute Respiratory Syndrome","Zhong, N.S., Zheng, B.J., Li, Y.M., Poon, Xie, Z.H., Chan, K.H., Li, P.H., Guan, Y., Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China in February 2003 (2003) Lancet, 362, p. 13531358; Nassar, M.S., Bakhrebah, M.A., Meo, S.A., Alsuabeyl, M.S., Zaher, W.A., Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection: Epidemiology, pathogenesis and clinical characteristics (2018) Eur Rev Med Pharmacol Sci, 22, pp. 4956-4961; Nassar, M.S., Bakhrebah, M.A., Meo, S.A., Alsuabeyl, M.S., Zaher, W.A., Global seasonal occurrence of middle east respiratory syndrome coronavirus (MERS-CoV) infection (2018) Eur Rev Med Pharmacol Sci, 22, pp. 3913-3918; Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Ren, R., Feng, Z., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med, , Jan 29. [Epub ahead of print; Wang, W., Tang, J., Wei, F., Updated understanding of the outbreak of 2019 novel coronavirus (2019-nCoV) in Wuhan (2020) China. J Med Virol, , Jan 29. [Epub ahead of print; Callaway, E., Cyranoski, D., China coronavirus: Six questions scientists are asking (2020) Nature, 577, pp. 605-607; World Health Organization: Coronavirus, , https://www.who.int/health-topics/coronavirus, Available at:, cited date Feb 8, 2020; World Health Organization, , https://www.who.int/csr/sars/country/2003_08_15/en/, Available at:, cited date Feb 8, 2020; World Health Organization, , https://www.who.int/emergencies/mers-cov/en/, cited date Feb 8, 2020; Centers for Disease Control and Prevention (CD), , https://www.cdc.gov/, Available at:, cited date Feb 8, 2020; Isi Web of Knowledge, , http://webofknowledge.com/JCR/JCR?PointOfEntry=Home&SID=4FeKpokbn-HkLlmE1OGe, Thomson Reuters, Available at:, Cited date Feb 8, 2020; Pub Med, , https://www.ncbi.nlm.nih.gov/pubmed/?term=Coronavrus, Available at:, cited date Feb 8, 2020; Rebecca Lai, K.K., Jin, W., Allison, M.C., Derek, W., Jugal, K.P., Richard, H., Coronavirus Map: Tracking the Spread of the Outbreak, , https://www.nytimes.com/interactive/2020/world/asia/china-wuhan-coronavirus-maps.html?action=-click&pgtype=Article&state=default&module=-styln-coronavirus®ion=TOP-BANNER&con-text=storyline-menu, Available at, Cited Date Jan Feb 8, 2020; Raj, V.S., Osterhaus, A.D.M.E., Fouchier, R.A.M., Haagmans, B.L., MERS: Emergence of a novel human coronavirus (2014) Curr Opin Virol, 5, pp. 58-62; Raj, V.S., Smits, S.L., Provacia, L.B., Van Den Brand, J.M., Wi-Ersma, L., Ouwendijk, W.J., Bestebroer, T.M., Haagmans, B.L., Adenosine deam-inase acts as a natural antagonist for dipeptidyl peptidase 4 mediated entry of the Middle East respiratory syndrome coronavirus (2014) J Virol, 88, pp. 1834-1838; Lee, J.Y., Kim, Y.J., Chung, E.H., Kim, D.W., Jeong, I., Kim, Y., Yun, M.R., Joh, J.S., The clinical and virological features of the first imported case causing MERS-CoV outbreak in South Korea 2015 (2017) Bmc Infect Dis, 17, p. 498; Alsaad, K., Hajeer, A.H., Al Balwi, M., Al, M.M., Al Oudah, N., Al Ajlan, A., AlJohani, S., Arabi, Y.M., Histopathology of Middle East respiratory syndrome coronovirus (MERS-CoV) infection-clinic-pathological and ultrastructural study (2018) Histopathology, 72, pp. 516-524; Aly, M., Elrobh, M., Alzayer, M., Aljuhani, S., Balkhy, H., Occurrence of the middle east respiratory syndrome coronavirus (Mers-Cov) across the gulf corporation council countries: Four years update (2017) PLoS One, 12, p. e0183850","Meo, S.A.; Department of Physiology, King Saud UniversitySaudi Arabia; email: sultanmeo@hotmail.com",,Verduci Editore s.r.l,11283602,,RESFD,32141570,English,Eur. Rev. Med. Pharmacol. Sci.,Review,Final,,Scopus,2-s2.0-85081531337,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Liu Z., Xiao X., Wei X., Li J., Yang J., Tan H., Zhu J., Zhang Q., Wu J., Liu L.",36550377400;57215779217;57205540283;57214207615;57212325379;57004129100;57215223291;57214795118;57188570786;57193755578;,Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS-CoV-2,2020,Journal of Medical Virology,,,,,,,5,10.1002/jmv.25726,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081543024&doi=10.1002%2fjmv.25726&partnerID=40&md5=a05ef8189be54ee8b4597752c2d779cf,"Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan, China; State Key Laboratory of Virology and College of Life Sciences, Wuhan University, Wuhan, China; Guangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University, Guangzhou, China; School of Public Health, Southern Medical University, Guangzhou, China","Liu, Z., Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan, China, State Key Laboratory of Virology and College of Life Sciences, Wuhan University, Wuhan, China; Xiao, X., Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan, China; Wei, X., Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan, China; Li, J., Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan, China; Yang, J., Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan, China; Tan, H., Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan, China; Zhu, J., Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan, China; Zhang, Q., Guangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University, Guangzhou, China, School of Public Health, Southern Medical University, Guangzhou, China; Wu, J., State Key Laboratory of Virology and College of Life Sciences, Wuhan University, Wuhan, China, Guangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University, Guangzhou, China; Liu, L., Department of Respiratory, Department of Infectious Diseases, School of Basic Medical Sciences, Renmin Hospital, Hubei University of Medicine, Shiyan, China","From the beginning of 2002 and 2012, severe respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) crossed the species barriers to infect humans, causing thousands of infections and hundreds of deaths, respectively. Currently, a novel coronavirus (SARS-CoV-2), which has become the cause of the outbreak of Coronavirus Disease 2019 (COVID-19), was discovered. Until 18 February 2020, there were 72 533 confirmed COVID-19 cases (including 10 644 severe cases) and 1872 deaths in China. SARS-CoV-2 is spreading among the public and causing substantial burden due to its human-to-human transmission. However, the intermediate host of SARS-CoV-2 is still unclear. Finding the possible intermediate host of SARS-CoV-2 is imperative to prevent further spread of the epidemic. In this study, we used systematic comparison and analysis to predict the interaction between the receptor-binding domain (RBD) of coronavirus spike protein and the host receptor, angiotensin-converting enzyme 2 (ACE2). The interaction between the key amino acids of S protein RBD and ACE2 indicated that, other than pangolins and snakes, as previously suggested, turtles (Chrysemys picta bellii, Chelonia mydas, and Pelodiscus sinensis) may act as the potential intermediate hosts transmitting SARS-CoV-2 to humans. © 2020 Wiley Periodicals, Inc.",angiotensin-converting enzyme 2 (ACE2); Coronavirus Disease 2019 (COVID-19); receptor-binding domain (RBD) of coronavirus; SARS-CoV-2; SARS-CoV-2 spike protein (S),,"Gorbalenya, A.E., Baker, S.C., Baric, R.S., (2020) Severe Acute Respiratory Syndrome-Related Coronavirus: The Species and Its viruses—A Statement of The Coronavirus Study Group, , https://doi.org/10.1101/2020.02.07.937862; Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382, pp. 727-733. , https://doi.org/10.1056/NEJMoa2001017; Tang, Q., Song, Y., Shi, M., Cheng, Y., Zhang, W., Xia, X.Q., Inferring the hosts of coronavirus using dual statistical models based on nucleotide composition (2015) Sci Rep, 5; 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Zhou, P., Yang, X.L., Wang, X.G., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature, , https://doi.org/10.1038/s41586-020-2012-7; Liu, P., Chen, W., Chen, J.P., Viral metagenomics revealed Sendai virus and coronavirus infection of Malayan pangolins (Manis javanica) (2019) Viruses, 11 (11), p. 979; Yu, W.B., Tang, G.D., Zhang, L., Decoding the evolution and transmissions of the novel pneumonia coronavirus (SARS-CoV-2) using whole genomic data ChinaXiv. 2020.02.00033v2; Lam, T.T., Shum, M.H., Zhu, H.C., Identification of 2019-nCoV related coronaviruses in Malayan pangolins in southern China bioRxiv. 2020.02.13.945485; Matthew, C.W., Sara, J.C., Nadim, J.A., Evidence of recombination in coronaviruses implicating pangolin origins of nCoV-2019 bioRxiv. 2020.02.07.939207; Graham, R.L., Baric, R.S., Recombination, reservoirs, and the modular spike: mechanisms of coronavirus cross-species transmission (2010) J Virol, 84 (7), pp. 3134-3146; Li, W., Zhang, C., Sui, J., Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2 (2005) EMBO J, 24 (8), pp. 1634-1643; Lu, G., Wang, Q., Gao, G.F., Bat-to-human: spike features determining host ‘host jump’ of coronaviruses SARS-CoV, MERS-CoV, and beyond (2015) Trends Microbiol, 23 (8), pp. 468-478; Zhang, L., Li, D., Liu, L., Fang, J., Xu, R., Zhang, G., Development of a colloidal gold immunochromatographic strip for the rapid detection of soft-shelled turtle systemic septicemia spherical virus (2015) J Virol Meth, 221, pp. 39-45; Ng, T.F., Manire, C., Borrowman, K., Langer, T., Ehrhart, L., Breitbart, M., Discovery of a novel single-stranded DNA virus from a sea turtle fibropapilloma by using viral metagenomics (2009) J Virol, 83 (6), pp. 2500-2509; Lyu, S., Yuan, X., Zhang, H., Transcriptome profiling analysis of lung tissue of Chinese soft-shell turtle infected by Trionyx sinensis Hemorrhagic syndrome virus (2020) Fish Shellfish Immunol, 98, pp. 653-660; Huang, Y., Huang, X., Wang, S., Yu, Y., Ni, S., Qin, Q., Soft-shelled turtle iridovirus enters cells via cholesterol-dependent, clathrin-mediated endocytosis as well as macropinocytosis (2018) Arch Virol, 163 (11), pp. 3023-3033; Zhang, J., Finlaison, D.S., Frost, M.J., Identification of a novel nidovirus as a potential cause of large scale mortalities in the endangered Bellinger River snapping turtle (Myuchelys georgesi) (2018) PLOS One, 13 (10); Ji, W., Wang, W., Zhao, X.F., Zai, J.J., Li, X.G., Homologous recombination within the spike glycoprotein of the newly identified coronavirus may boost cross-species transmission from snake to human (2020) J Med Virol, 92, pp. 433-440. , https://doi.org/10.1002/jmv.25682","Wu, J.; State Key Laboratory of Virology and College of Life Sciences, Wuhan UniversityChina; email: jwu898@jnu.edu.cn",,John Wiley and Sons Inc.,1466615,,JMVID,32100877,English,J. Med. Virol.,Article,Article in Press,Open Access,Scopus,2-s2.0-85081543024,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Yang C.-W., Chen M.-F.",7407022894;55733287000;,Composition of human-specific slow codons and slow di-codons in SARS-CoV and 2019-nCoV are lower than other coronaviruses suggesting a faster protein synthesis rate of SARS-CoV and 2019-nCoV,2020,"Journal of Microbiology, Immunology and Infection",,,,,,,,10.1016/j.jmii.2020.03.002,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081696166&doi=10.1016%2fj.jmii.2020.03.002&partnerID=40&md5=a79ee9420cb68370170c337494080fc9,"Department of Microbiology, Soochow University, Shih-Lin, Taipei 111, Taiwan; Department of Medical Research, Taipei Veterans General HospitalTaipei 112, Taiwan","Yang, C.-W., Department of Microbiology, Soochow University, Shih-Lin, Taipei 111, Taiwan; Chen, M.-F., Department of Medical Research, Taipei Veterans General HospitalTaipei 112, Taiwan","Translation of a genetic codon without a cognate tRNA gene is affected by both the cognate tRNA availability and the interaction with non-cognate isoacceptor tRNAs. Moreover, two consecutive slow codons (slow di-codons) lead to a much slower translation rate. Calculating the composition of host specific slow codons and slow di-codons in the viral protein coding sequences can predict the order of viral protein synthesis rates between different virus strains. Comparison of human-specific slow codon and slow di-codon compositions in the genomes of 590 coronaviruses infect humans revealed that the protein synthetic rates of 2019 novel coronavirus (2019-nCoV) and severe acute respiratory syndrome-related coronavirus (SARS-CoV) may be much faster than other coronaviruses infect humans. Analysis of host-specific slow codon and di-codon compositions provides links between viral genomic sequences and capability of virus replication in host cells that may be useful for surveillance of the transmission potential of novel viruses. © 2020",2019-nCoV; Host tRNA genes; Host-specific slow codons,,"Chan, P.P., Lowe, T.M., GtRNAdb: a database of transfer RNA genes detected in genomic sequence (2009) Nucleic Acids Res, 37, pp. D93-D97; Dana, A., Tuller, T., Determinants of translation elongation speed and ribosomal profiling biases in mouse embryonic stem cells (2012) PLoS Comput Biol, 8; Hussmann, J.A., Patchett, S., Johnson, A., Sawyer, S., Press, W.H., Understanding biases in ribosome profiling experiments reveals signatures of translation dynamics in yeast (2015) PLoS Genet, 11; Stadler, M., Fire, A., Wobble base-pairing slows in vivo translation elongation in metazoans (2011) RNA, 17, pp. 2063-2073; Chevance, F.F.V., Hughes, K.T., Case for the genetic code as a triplet of triplets (2017) Proc Natl Acad Sci USA, 114, pp. 4745-4750; Chevance, F.F.V., Le Guyon, S., Hughes, K.T., The effects of codon context on in vivo translation speed (2014) PLoS Genet, 10; Pickett, B.E., Sadat, E.L., Zhang, Y., Noronha, J.M., Squires, R.B., Hunt, V., ViPR: an open bioinformatics database and analysis resource for virology research (2012) Nucleic Acids Res, 40, pp. D593-D598; Larkin, M.A., Blackshields, G., Brown, N.P., Chenna, R., McGettigan, P.A., McWilliam, H., Clustal W and clustal X version 2.0 (2007) Bioinformatics, 23, pp. 2947-2948; de Wit, E., van Doremalen, N., Falzarano, D., Munster, V.J., SARS and MERS: recent insights into emerging coronaviruses (2016) Nat Rev Microbiol, 14, pp. 523-534; Song, Z., Xu, Y., Bao, L., Zhang, L., Yu, P., Qu, Y., From SARS to MERS, thrusting coronaviruses into the spotlight (2019) Viruses, 11, p. E59; Herfst, S., Böhringer, M., Karo, B., Lawrence, P., Lewis, N.S., Mina, M.J., Drivers of airborne human-to-human pathogen transmission (2017) Curr Opin Virol, 22, pp. 22-29","Yang, C.-W.; Department of Microbiology, Soochow UniversityTaiwan; email: ycw6861@scu.edu.tw",,Elsevier Ltd,16841182,,JMIIF,,English,J. Microbiol. Immunol. Infect.,Article,Article in Press,Open Access,Scopus,2-s2.0-85081696166,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wassenaar T.M., Zou Y.",7003271018;57215217483;,2019_nCoV/SARS-CoV-2: rapid classification of betacoronaviruses and identification of Traditional Chinese Medicine as potential origin of zoonotic coronaviruses,2020,Letters in Applied Microbiology,,,,,,,,10.1111/lam.13285,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080137616&doi=10.1111%2flam.13285&partnerID=40&md5=507ab844a4d80171f4187e24020fd831,"Molecular Microbiology and Genomics Consultants, Zotzenheim, Germany; SciPaperEdit, Chuangkexing, Wuhan, China","Wassenaar, T.M., Molecular Microbiology and Genomics Consultants, Zotzenheim, Germany; Zou, Y., SciPaperEdit, Chuangkexing, Wuhan, China","The current outbreak of a novel severe acute respiratory syndrome-like coronavirus, 2019_nCoV (now named SARS-CoV-2), illustrated difficulties in identifying a novel coronavirus and its natural host, as the coding sequences of various Betacoronavirus species can be highly diverse. By means of whole-genome sequence comparisons, we demonstrate that the noncoding flanks of the viral genome can be used to correctly separate the recognized four betacoronavirus subspecies. The conservation would be sufficient to define target sequences that could, in theory, classify novel virus species into their subspecies. Only 253 upstream noncoding sequences of Sarbecovirus are sufficient to identify genetic similarities between species of this subgenus. Furthermore, it was investigated which bat species have commercial value in China, and would thus likely be handled for trading purposes. A number of coronavirus genomes have been published that were obtained from such bat species. These bats are used in Traditional Chinese Medicine, and their handling poses a potential risk to cause zoonotic coronavirus epidemics. Significance and Impact of the Study: The noncoding upstream and downstream flanks of coronavirus genomes allow for rapid classification of novel Betacoronavirus species and correct identification of genetic relationships. Although bats are the likely natural host of 2019_nCoV, the exact bat species that serves as the natural host of the virus remains as yet unknown. Chinese bat species with commercial value were identified as natural reservoirs of coronaviruses and are used in Traditional Chinese Medicine. Since their trading provides a potential risk for spreading zoonoses, a change in these practices is highly recommended. © 2020 The Authors. Letters in Applied Microbiology published by John Wiley & Sons Ltd on behalf of Society for Applied Microbiology.",bats; coronavirus; epidemic; Sarbecovirus; Traditional Chinese Medicine; whole-genome comparison; zoonosis,,"Baharoon, S., Memish, Z.A., MERS-CoV as an emerging respiratory illness: a review of prevention methods (2019) Travel Med Infect Dis, 32. , https://doi.org/10.1016/j.tmaid.2019.101520; Bermingham, A., Chand, M.A., Brown, C.S., Aarons, E., Tong, C., Langrish, C., Hoschler, K., Brown, K., Severe respiratory illness caused by a novel coronavirus, in a patient transferred to the United Kingdom from the Middle East, September 2012 (2012) Euro Surveill, 17, p. 20290; Cho, S.Y., Kang, J.M., Ha, Y.E., Park, G.E., Lee, J.Y., Ko, J.H., Lee, J.Y., Kim, J.M., MERS-CoV outbreak following a single patient exposure in an emergency room in South Korea: an epidemiological outbreak study (2016) Lancet, 388, pp. 994-1001; Cui, J., Li, F., Shi, Z.L., Origin and evolution of pathogenic coronaviruses (2019) Nat Rev Microbiol, 17, pp. 181-192; Drexler, J.F., Corman, V.M., Drosten, C., Ecology, evolution and classification of bat coronaviruses in the aftermath of SARS (2014) Antiviral Res, 101, pp. 45-56; Guindon, S., Dufayard, J.F., Lefort, V., Anisimova, M., Hordijk, W., Gascuel, O., New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0 (2010) Syst Biol, 59, pp. 307-321; Hu, D., Zhu, C., Ai, L., He, T., Wang, Y., Ye, F., Yang, L., Ding, C., Genomic characterization and infectivity of a novel SARS-like coronavirus in Chinese bats (2018) Emerg Microbes Infect, 7, p. 154; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhan, L., Fan, G., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506; Kang, C.K., Song, K.H., Choe, P.G., Park, W.B., Bang, J.H., Kim, E.S., Park, S.W., Kim, H.B., Clinical and epidemiologic characteristics of spreaders of middle east respiratory syndrome coronavirus during the 2015 outbreak in Korea (2017) J Korean Med Sci, 32, pp. 744-749; Li, W., Shi, Z., Yu, M., Ren, W., Smith, C., Epstein, J.H., Wang, H., Crameri, G., Bats are natural reservoirs of SARS-like coronaviruses (2005) Science, 310, pp. 676-679; Liu, P., Chen, W., Chen, J.P., Viral metagenomics revealed sendai virus and coronavirus infection of Malayan pangolins (Manis javanica) (2019) Viruses, 11. , https://doi.org/10.3390/v11110979; Lu, R., Zhao, X., Li, J., Niu, P., Yang, B., Wu, H., Wang, W., Song, H., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet, , https://doi.org/10.1016/S0140-6736(20)30251-8; Mohd, H.A., Al-Tawfiq, J.A., Memish, Z.A., Middle east respiratory syndrome coronavirus (MERS-CoV) origin and animal reservoir (2016) Virol J, 13, p. 87; Riccucci, M., Bats as materia medica: an ethnomedical review and implications for conservation (2012) Vespertilio, 16, pp. 249-270; Riou, J., Althaus, C.L., Pattern of early human-to-human transmission of Wuhan 2019 novel coronavirus (2019-nCoV), December 2019 to January 2020 (2020) Eurosurveillance, 25. , https://doi.org/10.2807/1560-7917.ES.2020.25.4.2000058; Su, S., Wong, G., Shi, W., Liu, J., Lai, A.C.K., Zhou, J., Liu, W., Bi, Y., Epidemiology, genetic recombination, and pathogenesis of coronaviruses (2016) Trends Microbiol, 24, pp. 490-502; Tang, X.C., Zhang, J.X., Zhang, S.Y., Wang, P., Fan, X.H., Li, L.F., Li, G., Dong, B.Q., Prevalence and genetic diversity of coronaviruses in bats from China (2006) J Virol, 80, pp. 7481-7790; Wang, L.F., Eaton, B.T., Bats, civets and the emergence of SARS (2007) Curr Top Microbiol Immunol, 315, pp. 325-344; Zhang, N., Wang, L., Deng, X., Liang, R., Su, M., He, C., Hu, L., Recent advances in the detection of respiratory virus infection in humans (2020) J Med Virol, , https://doi.org/10.1002/jmv.25674","Wassenaar, T.M.; Molecular Microbiology and Genomics ConsultantsGermany; email: trudy@mmgc.eu",,Blackwell Publishing Ltd,2668254,,LAMIE,32060933,English,Lett. Appl. Microbiol.,Article,Article in Press,Open Access,Scopus,2-s2.0-85080137616,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Gralinski L.E., Menachery V.D.",6505609367;24281639500;,Return of the coronavirus: 2019-nCoV,2020,Viruses,12,2, v12020135,,,,17,10.3390/v12020135,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078688361&doi=10.3390%2fv12020135&partnerID=40&md5=3dbf1e6430096abfd7676f32b2158359,"Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27514, United States; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, United States; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555, United States","Gralinski, L.E., Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27514, United States; Menachery, V.D., Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555, United States, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555, United States","The emergence of a novel coronavirus (2019-nCoV) has awakened the echoes of SARSCoV from nearly two decades ago. 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Case Stud., 2, p. a001214. , [CrossRef] [PubMed]","Menachery, V.D.; Department of Microbiology and Immunology, University of Texas Medical BranchUnited States; email: Vimenach@utmb.edu",,MDPI AG,19994915,,,31991541,English,Viruses,Review,Final,Open Access,Scopus,2-s2.0-85078688361,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Huang W.-H., Teng L.-C., Yeh T.-K., Chen Y.-J., Lo W.-J., Wu M.-J., Chin C.-S., Tsan Y.-T., Lin T.-C., Chai J.-W., Lin C.-F., Tseng C.-H., Liu C.-W., Wu C.-M., Chen P.-Y., Shi Z.-Y., Liu P.-Y.",57215208568;57215194238;57215201717;57215198141;57215208644;24482826800;57215197821;10041369200;55608000400;57215202308;24490958000;56181290900;57211498035;57215200968;57203078676;7403734348;26326421500;,"2019 novel coronavirus disease (COVID-19) in Taiwan: Reports of two cases from Wuhan, China",2020,"Journal of Microbiology, Immunology and Infection",,,,,,,3,10.1016/j.jmii.2020.02.009,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080036716&doi=10.1016%2fj.jmii.2020.02.009&partnerID=40&md5=19c0da7c5c9bd23785c914f03deeb38a,"Division of Infectious Diseases, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Emergency Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Radiology, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Pathology and Laboratory Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Nursing, Taichung Veteran General Hospital, Taichung, Taiwan; Department of Pediatrics, Taichung Veterans General Hospital, Taichung, Taiwan; Infection Control Center, Taichung Veterans General Hospital, Taichung, Taiwan; Ph.D. Program in Translational Medicine, National Chung Hsing University, Taichung, Taiwan; Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung, Taiwan","Huang, W.-H., Division of Infectious Diseases, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Teng, L.-C., Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Yeh, T.-K., Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Chen, Y.-J., Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Lo, W.-J., Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Wu, M.-J., Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Chin, C.-S., Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Tsan, Y.-T., Department of Emergency Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Lin, T.-C., Department of Emergency Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Chai, J.-W., Department of Radiology, Taichung Veterans General Hospital, Taichung, Taiwan; Lin, C.-F., Department of Pathology and Laboratory Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Tseng, C.-H., Division of Infectious Diseases, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Liu, C.-W., Division of Infectious Diseases, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Wu, C.-M., Department of Nursing, Taichung Veteran General Hospital, Taichung, Taiwan; Chen, P.-Y., Department of Pediatrics, Taichung Veterans General Hospital, Taichung, Taiwan; Shi, Z.-Y., Infection Control Center, Taichung Veterans General Hospital, Taichung, Taiwan; Liu, P.-Y., Division of Infectious Diseases, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, Ph.D. Program in Translational Medicine, National Chung Hsing University, Taichung, Taiwan, Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung, Taiwan","We reported two cases with community-acquired pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who returned from Wuhan, China in January, 2020. The reported cases highlight non-specific clinical presentations of 2019 novel coronavirus disease (COVID-19) as well as the importance of rapid laboratory-based diagnosis. © 2020",COVID-19; Emerging infectious diseases; Pneumonia; SARS-CoV-2; Zoonosis,,"Wu, A., Peng, Y., Huang, B., Ding, X., Wang, X., Niu, P., Genome Composition and divergence of the novel coronavirus (2019-nCoV) originating in China (2020) Cell Host Microbe, , pii: S1931-3128(20)30072-X; Yen, M.Y., Chiu, A.W., Schwartz, J., King, C.C., Lin, Y.E., Chang, S.C., From SARS in 2003 to H1N1 in 2009: lessons learned from Taiwan in preparation for the next pandemic (2014) J Hosp Infect, 87, pp. 185-193; Hsueh, P.R., Hsiao, C.H., Yeh, S.H., Wang, W.K., Chen, P.J., Wang, J.T., Microbiologic characteristics, serologic responses, and clinical manifestations in severe acute respiratory syndrome, Taiwan (2003) Emerg Infect Dis, 9, pp. 1163-1167; Lee, P.I., Hsueh, P.R., Emerging threats from zoonotic coronaviruses-from SARS and MERS to 2019-nCoV (2020) J Microbiol Immunol Infect, , pii: S1684-1182(20)30011-30016; Lai, C.C., Shih, T.P., Ko, W.C., Tang, H.J., Hsueh, P.R., Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and corona virus disease-2019 (COVID-19): the epidemic and the challenges (2020) Int J Antimicrob Agents; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, , pii: S0140-6736(20)30183-30185; Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, , pii: S0140-6736(20)30211-30217; Peiris, J.S., Chu, C.M., Cheng, V.C., Chan, K.S., Hung, I.F., Poon, L.L., Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study (2003) Lancet, 361, pp. 1767-1772; Holshue, M.L., DeBolt, C., Lindquist, S., Lofy, K.H., Wiesman, J., Bruce, H., First case of 2019 novel coronavirus in the United States (2020) N Engl J Med; Wu, F., Zhao, S., Yu, B., Chen, Y.M., Wang, W., Song, Z.G., A new coronavirus associated with human respiratory disease in China (2020) Nature; Jain, S., Self, W.H., Wunderink, R.G., Fakhran, S., Balk, R., Bramley, A.M., Community-acquired pneumonia requiring hospitalization among U.S. Adults (2015) N Engl J Med, 373, pp. 415-427; Chou, C.C., Shen, C.F., Chen, S.J., Chen, H.M., Wang, Y.C., Chang, W.S., Recommendations and guidelines for the treatment of pneumonia in Taiwan (2019) J Microbiol Immunol Infect, 52, pp. 172-199","Liu, P.-Y.; Division of Infectious Diseases, Department of Internal Medicine, Taichung Veterans General Hospital, Taiwan Boulevard Sect. 4, Taiwan; email: pyliu@vghtc.gov.tw",,Elsevier Ltd,16841182,,JMIIF,,English,J. Microbiol. Immunol. Infect.,Article,Article in Press,Open Access,Scopus,2-s2.0-85080036716,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "He F., Deng Y., Li W.",57215937365;57215934453;53865248500;,Coronavirus disease 2019: What we know?,2020,Journal of Medical Virology,,,,,,,,10.1002/jmv.25766,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082432821&doi=10.1002%2fjmv.25766&partnerID=40&md5=3bbcaf072d39c8ea728128c265b4a413,"Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","He, F., Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Deng, Y., Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Li, W., Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","In late December 2019, a cluster of unexplained pneumonia cases has been reported in Wuhan, China. A few days later, the causative agent of this mysterious pneumonia was identified as a novel coronavirus. This causative virus has been temporarily named as severe acute respiratory syndrome coronavirus 2 and the relevant infected disease has been named as coronavirus disease 2019 (COVID-19) by the World Health Organization, respectively. The COVID-19 epidemic is spreading in China and all over the world now. The purpose of this review is primarily to review the pathogen, clinical features, diagnosis, and treatment of COVID-19, but also to comment briefly on the epidemiology and pathology based on the current evidence. © 2020 The Authors. 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Wang, W., Tang, J., Wei, F., Updated understanding of the outbreak of 2019 novel coronavirus (2019-nCoV) in Wuhan, China (2020) J Med Virol, 92 (4), pp. 441-447","Li, W.; Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyChina; email: weina_li@live.cn",,John Wiley and Sons Inc.,1466615,,JMVID,32170865,English,J. Med. Virol.,Review,Article in Press,Open Access,Scopus,2-s2.0-85082432821,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Lu H.,7404842614;,Drug treatment options for the 2019-new coronavirus (2019-nCoV),2020,BioScience Trends,14,1,1020,,,,19,10.5582/BST.2020.01020,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082096467&doi=10.5582%2fBST.2020.01020&partnerID=40&md5=92774445661d77b62e2fb3c3440ba289,"Scientific Research Center, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China; Department of Infectious Diseases, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China; Department of Infectious Disease, Huashan Hospital Affiliated to Fudan University, Shanghai, China","Lu, H., Scientific Research Center, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China, Department of Infectious Diseases, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China, Department of Infectious Disease, Huashan Hospital Affiliated to Fudan University, Shanghai, China","As of January 22, 2020, a total of 571 cases of the 2019-new coronavirus (2019-nCoV) have been reported in 25 provinces (districts and cities) in China. At present, there is no vaccine or antiviral treatment for human and animal coronavirus, so that identifying the drug treatment options as soon as possible is critical for the response to the 2019-nCoV outbreak. Three general methods, which include existing broad-spectrum antiviral drugs using standard assays, screening of a chemical library containing many existing compounds or databases, and the redevelopment of new specific drugs based on the genome and biophysical understanding of individual coronaviruses, are used to discover the potential antiviral treatment of human pathogen coronavirus. Lopinavir /Ritonavir, Nucleoside analogues, Neuraminidase inhibitors, Remdesivir, peptide (EK1), arbidol, RNA synthesis inhibitors (such as TDF, 3TC), anti-inflammatory drugs (such as hormones and other molecules), Chinese traditional medicine, such ShuFengJieDu Capsules and Lianhuaqingwen Capsule, could be the drug treatment options for 2019-nCoV. However, the efficacy and safety of these drugs for 2019-nCoV still need to be further confirmed by clinical experiments. © 2020 International Advancement Center for Medicine and Health Research Co., Ltd.",2019-nCoV; Coronaviruses; Pneumonia,"alanine; antivirus agent; COVID-19; lopinavir; lopinavir-ritonavir drug combination; nucleoside; remdesivir; ribonucleotide; ritonavir; severe acute respiratory syndrome coronavirus 2; sialidase; Betacoronavirus; Coronavirus infection; drug combination; drug development; human; virus pneumonia; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; Drug Combinations; Drug Discovery; Humans; Lopinavir; Neuraminidase; Nucleosides; Pneumonia, Viral; Ribonucleotides; Ritonavir","Pneumonia epidemic situation of new coronavirus infection on January 23, 2020 (2020), http://www.nhc.gov.cn/yjb/s3578/202001/5d19a4f6d3154b9fae328918ed2e3c8a.shtml, accessed January 23; Imai, N., Report 2: Estimating the potential total number of novel Coronavirus cases in Wuhan City, China (2020), http://www.imperial.ac.uk/mrc-global-infectious-disease-analysis/news--wuhan-coronavirus/, accessed January 23; Lu, H., Stratton, C.W., Tang, Y.W., Outbreak of Pneumonia of Unknown Etiology in Wuhan China: the Mystery and the Miracle (2020) J Med Virol.; Kim, Y., Liu, H., Galasiti Kankanamalage, A.C., Weerasekara, S., Hua, D.H., Groutas, W.C., Chang, K.O., Pedersen, N.C., Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor (2016) PLoS Pathog, 12; Channappanavar, R., Fett, C., Mack, M., Ten Eyck, P.P., Meyerholz, D.K., Perlman, S., Sex-Based Differences in Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection (2017) J Immunol, 198, pp. 4046-4053; Zumla, A., Chan, J.F., Azhar, E.I., Hui, D.S., Yuen, K.Y., Coronaviruses - drug discovery and therapeutic options (2016) Nat Rev Drug Discov, 15, pp. 327-347; Notice on printing and distributing the diagnosis and treatment plan of pneumonia with new coronavirus infection (trial version 3) (2020), http://www.nhc.gov.cn/yzygj/s7653p/202001/f492c9153ea9437bb587ce2ffcbee1fa.shtml, accessed January 23; Chu, C.M., Cheng, V.C., Hung, I.F., Wong, M.M., Chan, K.H., Chan, K.S., Kao, R.Y., Yuen, K.Y., Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings (2004) Thorax., 59, pp. 252-256; Arabi, Y.M., Alothman, A., Balkhy, H.H., Treatment of Middle East Respiratory Syndrome with a combination of lopinavir-ritonavir and interferon-bβ1b (MIRACLE trial): study protocol for a randomized controlled trial (2018) Trials, 19, p. 81; Wang, Y., Fan, G., Salam, A., Horby, P., Hayden, F.G., Chen, C., Pan, J., Cao, B., CAP-China Network. Comparative effectiveness of combined favipiravir and oseltamivir therapy versus oseltamivir monotherapy in critically ill patients with influenza virus infection (2019) J Infect Dis., p. jiz656; Sheahan, T.P., Sims, A.C., Leist, S.R., Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV (2020) Nat Commun., 11, p. 222; Agostini, M.L., Andres, E.L., Sims, A.C., Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease (2018) mBio, 9; Chow, E.J., Doyle, J.D., Uyeki, T.M., Influenza virus-related critical illness: prevention, diagnosis, treatment (2019) Crit Care., 23, p. 214; Bleibtreu, A., Jaureguiberry, S., Houhou, N., Boutolleau, D., Guillot, H., Vallois, D., Lucet, J.C., Yazdanapanah, Y., Clinical management of respiratory syndrome in patients hospitalized for suspected Middle East respiratory syndrome coronavirus infection in the Paris area from 2013 to 2016 (2018) BMC Infect Dis, 18, p. 331; Xia, S., Yan, L., Xu, W., Agrawal, A.S., Algaissi, A., Tseng, C.K., Wang, Q., Lu, L., A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike (2019) Sci Adv, 5, p. eaav4580; Coleman, C.M., Sisk, J.M., Mingo, R.M., Nelson, E.A., White, J.M., Frieman, M.B., Abelson Kinase Inhibitors Are Potent Inhibitors of Severe Acute Respiratory Syndrome Coronavirus and Middle East Respiratory Syndrome Coronavirus Fusion (2016) J Virol, 90, pp. 8924-8933; Ji, S., Bai, Q., Wu, X., Zhang, D.W., Wang, S., Shen, J.L., Fei, G.H., Unique synergistic antiviral effects of Shufeng Jiedu Capsule and oseltamivir in influenza A viral-induced acute exacerbation of chronic obstructive pulmonary disease (2020) Biomed Pharmacother, 121, p. 109652; Ding, Y., Zeng, L., Li, R., Chen, Q., Zhou, B., Chen, Q., Cheng, P.L., Zhang, F., The Chinese prescription lianhuaqingwen capsule exerts anti-influenza activity through the inhibition of viral propagation and impacts immune function (2017) BMC Complement Altern Med, 17, p. 130","Lu, H.; Scientific Research Center, Shanghai Public Health Clinical Center, Fudan University, No.2901, Caolang Road, China; email: luhongzhou@fudan.edu.cn",,"International Advancement Center for Medicine and Health Research Co., Ltd.",18817815,,,31996494,English,BioScience Trends,Article,Final,Open Access,Scopus,2-s2.0-85082096467,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Chen L., Liu W., Zhang Q., Xu K., Ye G., Wu W., Sun Z., Liu F., Wu K., Zhong B., Mei Y., Zhang W., Chen Y., Li Y., Shi M., Lan K., Liu Y.",55235865800;57214720432;57212799799;57214533562;57214729717;57214721010;37056491700;57091145200;57214725152;57197711343;57214725834;57214722266;56399209300;27172163600;25951822000;7005370055;7410231924;,RNA based mNGS approach identifies a novel human coronavirus from two individual pneumonia cases in 2019 Wuhan outbreak,2020,Emerging Microbes and Infections,9,1,,313,319,,6,10.1080/22221751.2020.1725399,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078975424&doi=10.1080%2f22221751.2020.1725399&partnerID=40&md5=32a0885b42bc138f19c9d3e19c46c5d8,"State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, China; Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China; Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; School of Medicine, Sun yat-Sen University, Guangzhou, China","Chen, L., State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, China, Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China; Liu, W., Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Zhang, Q., State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, China; Xu, K., State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, China; Ye, G., Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China; Wu, W., School of Medicine, Sun yat-Sen University, Guangzhou, China; Sun, Z., Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Liu, F., State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, China; Wu, K., State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, China; Zhong, B., State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, China; Mei, Y., State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, China; Zhang, W., State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, China; Chen, Y., State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, China; Li, Y., Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China; Shi, M., School of Medicine, Sun yat-Sen University, Guangzhou, China; Lan, K., State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, China; Liu, Y., State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, China","From December 2019, an outbreak of unusual pneumonia was reported in Wuhan with many cases linked to Huanan Seafood Market that sells seafood as well as live exotic animals. We investigated two patients who developed acute respiratory syndromes after independent contact history with this market. The two patients shared common clinical features including fever, cough, and multiple ground-glass opacities in the bilateral lung field with patchy infiltration. Here, we highlight the use of a low-input metagenomic next-generation sequencing (mNGS) approach on RNA extracted from bronchoalveolar lavage fluid (BALF). It rapidly identified a novel coronavirus (named 2019-nCoV according to World Health Organization announcement) which was the sole pathogens in the sample with very high abundance level (1.5% and 0.62% of total RNA sequenced). The entire viral genome is 29,881 nt in length (GenBank MN988668 and MN988669, Sequence Read Archive database Bioproject accession PRJNA601736) and is classified into β-coronavirus genus. Phylogenetic analysis indicates that 2019-nCoV is close to coronaviruses (CoVs) circulating in Rhinolophus (Horseshoe bats), such as 98.7% nucleotide identity to partial RdRp gene of bat coronavirus strain BtCoV/4991 (GenBank KP876546, 370 nt sequence of RdRp and lack of other genome sequence) and 87.9% nucleotide identity to bat coronavirus strain bat-SL-CoVZC45 and bat-SL-CoVZXC21. Evolutionary analysis based on ORF1a/1b, S, and N genes also suggests 2019-nCoV is more likely a novel CoV independently introduced from animals to humans. © 2020, © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd.",2019-nCoV; metagenomic next-generation sequencing; phylogenetic analyses; virus evolution; Wuhan pneumonia,"antiinfective agent; antivirus agent; RNA; COVID-19; severe acute respiratory syndrome coronavirus 2; virus RNA; adult; amino acid sequence; Article; bronchoalveolar lavage fluid; Capnocytophaga; case report; clinical article; clinical feature; computer assisted tomography; Coronaviridae infection; Coronavirinae; coughing; dyspnea; epidemic; fever; gene mapping; high throughput sequencing; human; male; mental health; metagenomics; nucleotide sequence; phylogeny; pleura effusion; pneumonia; priority journal; respiratory failure; RNA extraction; RNA sequence; SARS coronavirus; sequence homology; single nucleotide polymorphism; statistically significant result; Veillonella; virus genome; virus identification; virus infection; young adult; Betacoronavirus; China; Coronavirus infection; epidemic; female; genetics; virus pneumonia; Adult; Betacoronavirus; China; Coronavirus Infections; Disease Outbreaks; Female; Genome, Viral; Humans; Male; Phylogeny; Pneumonia, Viral; RNA, Viral; Young Adult","Gu, W., Miller, S., Chiu, C.Y., Clinical metagenomic next-generation sequencing for pathogen detection (2019) Annu Rev Pathol, 14, pp. 319-338; Shi, M., Zhang, Y.Z., Holmes, E.C., Meta-transcriptomics and the evolutionary biology of RNA viruses (2018) Virus Res, 243, pp. 83-90; Jiang, S., Du, L., Shi, Z., An emerging coronavirus causing pneumonia outbreak in Wuhan, China: calling for developing therapeutic and prophylactic strategies (2020) Emerg Microbes Infect, 9, pp. 275-277; Buchfink, B., Xie, C., Huson, D.H., Fast and sensitive protein alignment using DIAMOND (2015) Nat Methods, 12, pp. 59-60; Truong, D.T., Franzosa, E.A., Tickle, T.L., Metaphlan2 for enhanced metagenomic taxonomic profiling (2015) Nat Methods, 12, pp. 902-903; Li, D., Liu, C.M., Luo, R., MEGAHIT: an ultra-fast single-node solution for large and complex metagenomics assembly via succinct de Bruijn graph (2015) Bioinformatics, 31, pp. 1674-1676; Guindon, S., Dufayard, J.F., Lefort, V., New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0 (2010) Syst Biol, 59, pp. 307-321; Lole, K.S., Bollinger, R.C., Paranjape, R.S., Full-length human immunodeficiency virus type 1 genomes from subtype C-infected seroconverters in India, with evidence of intersubtype recombination (1999) J Virol, 73, pp. 152-160; Gu, W., Miller, S., Chiu, C.Y., Clinical metagenomic next-generation sequencing for pathogen detection (2019) Annu Rev Pathol, 14, pp. 319-338; Shi, M., Neville, P., Nicholson, J., High-resolution metatranscriptomics reveals the ecological dynamics of mosquito-associated RNA viruses in Western Australia (2017) J Virol, 91 (17); Hu, B., Zeng, L.P., Yang, X.L., Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus (2017) PLoS Pathog, 13, p. e1006698; Menachery, V.D., Yount, B.L., Jr., Debbink, K., A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence (2015) Nat Med, 21, pp. 1508-1513; Chan, J.F., Kok, K.H., Zhu, Z., Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from patients with acute respiratory disease in Wuhan, Hubei, China (2020) Emerg Microbes Infect, 9, pp. 221-236","Chen, Y.; State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan UniversityChina; email: chenyu@whu.edu.cn",,Taylor and Francis Ltd.,22221751,,,32020836,English,Emerg. Microbes Infect.,Article,Final,Open Access,Scopus,2-s2.0-85078975424,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Chan J.F.-W., Kok K.-H., Zhu Z., Chu H., To K.K.-W., Yuan S., Yuen K.-Y.",24278817900;7006862631;57192312759;35781456400;14323807300;55364121100;36078079100;,Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan,2020,Emerging Microbes and Infections,9,1,,221,236,,32,10.1080/22221751.2020.1719902,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078500139&doi=10.1080%2f22221751.2020.1719902&partnerID=40&md5=b5227b5475bb2082cd3e093d6ba63f27,"State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong; Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, China; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong; Carol Yu Centre for Infection, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong","Chan, J.F.-W., State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong, Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, China, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, Carol Yu Centre for Infection, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong; Kok, K.-H., State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, Carol Yu Centre for Infection, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong; Zhu, Z., Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong; Chu, H., State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, Carol Yu Centre for Infection, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong; To, K.K.-W., State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong, Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, China, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, Carol Yu Centre for Infection, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong; Yuan, S., State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, Carol Yu Centre for Infection, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong; Yuen, K.-Y., Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, China, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, Carol Yu Centre for Infection, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong","A mysterious outbreak of atypical pneumonia in late 2019 was traced to a seafood wholesale market in Wuhan of China. Within a few weeks, a novel coronavirus tentatively named as 2019 novel coronavirus (2019-nCoV) was announced by the World Health Organization. We performed bioinformatics analysis on a virus genome from a patient with 2019-nCoV infection and compared it with other related coronavirus genomes. Overall, the genome of 2019-nCoV has 89% nucleotide identity with bat SARS-like-CoVZXC21 and 82% with that of human SARS-CoV. The phylogenetic trees of their orf1a/b, Spike, Envelope, Membrane and Nucleoprotein also clustered closely with those of the bat, civet and human SARS coronaviruses. However, the external subdomain of Spike’s receptor binding domain of 2019-nCoV shares only 40% amino acid identity with other SARS-related coronaviruses. Remarkably, its orf3b encodes a completely novel short protein. Furthermore, its new orf8 likely encodes a secreted protein with an alpha-helix, following with a beta-sheet(s) containing six strands. Learning from the roles of civet in SARS and camel in MERS, hunting for the animal source of 2019-nCoV and its more ancestral virus would be important for understanding the origin and evolution of this novel lineage B betacoronavirus. These findings provide the basis for starting further studies on the pathogenesis, and optimizing the design of diagnostic, antiviral and vaccination strategies for this emerging infection. © 2020, © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd.",bioinformatics; Coronavirus; emerging; genome; respiratory; SARS; virus; Wuhan,"coronavirus spike glycoprotein; membrane protein; nonstructural protein 1; nonstructural protein 10; nonstructural protein 11; nonstructural protein 12; nonstructural protein 13; nonstructural protein 14; nonstructural protein 15; nonstructural protein 16; nonstructural protein 2; nonstructural protein 3; nonstructural protein 4; nonstructural protein 5; nonstructural protein 6; nonstructural protein 7; nonstructural protein 8; nonstructural protein 9; nucleotide; open reading frame 3a protein; open reading frame 3b protein; open reading frame 6 protein; open reading frame 7a protein; open reading frame 7b protein; open reading frame 9b protein; single stranded RNA; unclassified drug; viral protein; virus envelope protein; virus nucleoprotein; virus RNA; COVID-19; severe acute respiratory syndrome coronavirus 2; viral protein; 2019 novel coronavirus; alpha helix; amino acid sequence; Article; bat; beta sheet; Betacoronavirus; bioinformatics; camel; China; civet (animal); Coronavirus infection; genome analysis; Middle East respiratory syndrome coronavirus; nonhuman; nucleotide sequence; nucleotide sequence; open reading frame; phylogenetic tree; priority journal; protein structure; receptor binding domain; SARS coronavirus; SARS-related coronavirus; strain difference; virus envelope; virus genome; virus isolation; virus pneumonia; virus spike; Betacoronavirus; chemistry; genetics; human; isolation and purification; phylogeny; sequence analysis; travel; virology; Amino Acid Sequence; Betacoronavirus; China; Coronavirus Infections; Genome, Viral; Humans; Phylogeny; Pneumonia, Viral; Sequence Analysis, Protein; Travel; Viral Proteins","Chan, J.F., To, K.K., Tse, H., Interspecies transmission and emergence of novel viruses: lessons from bats and birds (2013) Trends Microbiol, 21 (10), pp. 544-555. , Oct; Cheng, V.C., Lau, S.K., Woo, P.C., Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection (2007) Clin Microbiol Rev, 20 (4), pp. 660-694. , Oct; Chan, J.F., Lau, S.K., To, K.K., Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease (2015) Clin Microbiol Rev, 28 (2), pp. 465-522. , Apr; Woo, P.C., Lau, S.K., Chu, C.M., Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia (2005) J Virol, 79 (2), pp. 884-895. , Jan; Peiris, J.S., Lai, S.T., Poon, L.L., Yuen KY; SARS study group. coronavirus as a possible cause of severe acute respiratory syndrome (2003) Lancet, 361 (9366), pp. 1319-1325. , Apr 19; Yeung, M.L., Yao, Y., Jia, L., MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2 (2016) Nat Microbiol, 1, p. 16004. , Feb 22; https://www.who.int/westernpacific/emergencies/novel-coronavirus, [cited 2020 Jan 16]. 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[Epub ahead of print]; Chan, J.F., Yuan, S., Kok, K.H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, , https://doi.org/10.1016/S0140-6736(20, 30154-9 [Epub ahead of print]; Saitou, N., Nei, M., The neighbor-joining method: a new method for reconstructing phylogenetic trees (1987) Mol Biol Evol, 4 (4), pp. 406-425. , Jul; Felsenstein, J., Confidence limits on phylogenies: an approach using the bootstrap (1985) Evolution, 39 (4), pp. 783-791. , Jul; Zuckerkandl, E., Pauling, L., Evolutionary divergence and convergence in proteins (1965) Evolving genes and proteins, pp. 97-166. , Bryson V., Vogel H.J., (eds), New York: Academic Press,. In:, editors.,. p; Kumar, S., Stecher, G., Li, M., MEGA x: Molecular evolutionary Genetics analysis across computing platforms (2018) Mol Biol Evol, 35 (6), pp. 1547-1549. , Jun 1; Buchan, D.W.A., Jones, D.T., The PSIPRED protein analysis Workbench: 20 years on (2019) Nucleic Acids Res, 47 (W1), pp. W402-W407; Wang, Q., Qi, J., Yuan, Y., Bat origins of MERS-CoV supported by bat coronavirus HKU4 usage of human receptor CD26 (2014) Cell Host Microbe, 16 (3), pp. 328-337. , Sep 10; Xia, S., Yan, L., Xu, W., A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike (2019) Sci Adv, 5 (4), p. eaav4580. , Apr 10; Yount, B., Roberts, R.S., Sims, A.C., Severe acute respiratory syndrome coronavirus group-specific open reading frames encode nonessential functions for replication in cell cultures and mice (2005) J Virol, 79 (23), pp. 14909-14922. , Dec; Khan, S., Fielding, B.C., Tan, T.H., Over-expression of severe acute respiratory syndrome coronavirus 3b protein induces both apoptosis and necrosis in Vero E6 cells (2006) Virus Res, 122 (1-2), pp. 20-27. , Dec; Kopecky-Bromberg, S.A., Martinez-Sobrido, L., Frieman, M., Severe acute respiratory syndrome coronavirus open reading frame (orf) 3b, orf 6, and nucleocapsid proteins function as interferon antagonists (2007) J Virol, 81 (2), pp. 548-557. , Jan; Zhou, P., Li, H., Wang, H., Bat severe acute respiratory syndrome-like coronavirus ORF3b homologues display different interferon antagonist activities (2012) J Gen Virol, 93, pp. 275-281. , Feb; Song, H.D., Tu, C.C., Zhang, G.W., Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human (2005) Proc Natl Acad Sci U S A, 102 (7), pp. 2430-2435. , Feb 15; Oostra, M., de Haan, C.A., Rottier, P.J., The 29-nucleotide deletion present in human but not in animal severe acute respiratory syndrome coronaviruses disrupts the functional expression of open reading frame 8 (2007) J Virol, 81, pp. 13876-13888; Lau, S.K., Feng, Y., Chen, H., Severe acute respiratory syndrome (SARS) coronavirus ORF8 protein Is acquired from SARS-related coronavirus from Greater horseshoe bats through recombination (2015) J Virol, 89 (20), pp. 10532-10547. , Oct; Shi, C.S., Nabar, N.R., Huang, N.N., SARS-Coronavirus Open reading frame-8b triggers intracellular stress pathways and activates NLRP3 inflammasomes (2019) Cell Death Discov, 5, p. 101; Yang, D., Leibowitz, J.L., The structure and functions of coronavirus genomic 3’ and 5’ ends (2015) Virus Res, 206, pp. 120-133. , Aug 3","Kok, K.-H.; State Key Laboratory of Emerging Infectious Diseases, The University of Hong KongHong Kong; email: khkok@hku.hk",,Taylor and Francis Ltd.,22221751,,,31987001,English,Emerg. Microbes Infect.,Article,Final,Open Access,Scopus,2-s2.0-85078500139,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Yao T.-T., Qian J.-D., Zhu W.-Y., Wang Y., Wang G.-Q.",57215687412;57201482057;57215681806;56084249700;7407149871;,A systematic review of lopinavir therapy for SARS coronavirus and MERS coronavirus—A possible reference for coronavirus disease-19 treatment option,2020,Journal of Medical Virology,,,,,,,1,10.1002/jmv.25729,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081699322&doi=10.1002%2fjmv.25729&partnerID=40&md5=2c00369bafb1107aee31d18ca89c4f11,"Department of Infectious Diseases and the Center for Liver Diseases, Peking University First Hospital, Beijing, China; The Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, Zhejiang, China; Peking University International Hospital, Beijing, China","Yao, T.-T., Department of Infectious Diseases and the Center for Liver Diseases, Peking University First Hospital, Beijing, China; Qian, J.-D., Department of Infectious Diseases and the Center for Liver Diseases, Peking University First Hospital, Beijing, China; Zhu, W.-Y., Department of Infectious Diseases and the Center for Liver Diseases, Peking University First Hospital, Beijing, China; Wang, Y., Department of Infectious Diseases and the Center for Liver Diseases, Peking University First Hospital, Beijing, China; Wang, G.-Q., Department of Infectious Diseases and the Center for Liver Diseases, Peking University First Hospital, Beijing, China, The Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, Zhejiang, China, Peking University International Hospital, Beijing, China","In the past few decades, coronaviruses have risen as a global threat to public health. Currently, the outbreak of coronavirus disease-19 (COVID-19) from Wuhan caused a worldwide panic. There are no specific antiviral therapies for COVID-19. However, there are agents that were used during the severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) epidemics. We could learn from SARS and MERS. Lopinavir (LPV) is an effective agent that inhibits the protease activity of coronavirus. In this review, we discuss the literature on the efficacy of LPV in vitro and in vivo, especially in patients with SARS and MERS, so that we might clarify the potential for the use of LPV in patients with COVID-19. © 2020 The Authors. Journal of Medical Virology published by Wiley Periodicals, Inc.",coronavirus; COVID-19; lopinavir; MERS; SARS,,"Chan-Yeung, M., Xu, R.H., SARS: epidemiology (2003) Respirology, 8, pp. S9-S14; Zaki, A.M., van Boheemen, S., Bestebroer, T.M., Osterhaus, A.D., Fouchier, R.A., Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia (2012) N Engl J Med, 367 (19), pp. 1814-1820; https://www.who.int/emergencies/mers-cov/en/, Middle East respiratory syndrome coronavirus (MERS-CoV)., Accessed; Zhou, P., Yang, X.L., Wang, X.G., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature, , https://doi.org/10.1038/s41586-020-2012-7; Hurst, M., Faulds, D., Lopinavir (2000) Drugs, 60 (6), pp. 1380-1381; de Wilde, A.H., Jochmans, D., Posthuma, C.C., Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture (2014) Antimicrob Agents Chemother, 58 (8), pp. 4875-4884; Sheahan, T.P., Sims, A.C., Leist, S.R., Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV (2020) Nat Commun, 11 (1), p. 222; Boffito, M., Arnaudo, I., Raiteri, R., Clinical use of lopinavir/ritonavir in a salvage therapy setting: pharmacokinetics and pharmacodynamics (2002) AIDS, 16 (15), pp. 2081-2083; Nukoolkarn, V., Lee, V.S., Malaisree, M., Aruksakulwong, O., Hannongbua, S., Molecular dynamic simulations analysis of ritonavir and lopinavir as SARS-CoV 3CL(pro) inhibitors (2008) J Theor Biol, 254 (4), pp. 861-867; Zhang, X.W., Yap, Y.L., Old drugs as lead compounds for a new disease? 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Med. Virol.,Review,Article in Press,Open Access,Scopus,2-s2.0-85081699322,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Schwartz D.A., Graham A.L.",56713369500;57215191259;,"Potential maternal and infant outcomes from coronavirus 2019-NCOV (SARS-CoV-2) infecting pregnant women: Lessons from SARS, MERS, and other human coronavirus infections",2020,Viruses,12,2,194,,,,5,10.3390/v12020194,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079335720&doi=10.3390%2fv12020194&partnerID=40&md5=4e8ed67d5664c96f1d73a062b5ceb9b9,"Medical College of Georgia, Augusta University, Augusta, GA 30912, United States; Department of Anthropology, University of Connecticut, Storrs, CT 06269, United States","Schwartz, D.A., Medical College of Georgia, Augusta University, Augusta, GA 30912, United States; Graham, A.L., Department of Anthropology, University of Connecticut, Storrs, CT 06269, United States","In early December 2019 a cluster of cases of pneumonia of unknown cause was identified in Wuhan, a city of 11 million persons in the People’s Republic of China. Further investigation revealed these cases to result from infection with a newly identified coronavirus, initially termed 2019-nCoV and subsequently SARS-CoV-2. The infection moved rapidly through China, spread to Thailand and Japan, extended into adjacent countries through infected persons travelling by air, eventually reaching multiple countries and continents. Similar to such other coronaviruses as those causing the Middle East respiratory syndrome (MERS) and severe acute respiratory syndrome (SARS), the new coronavirus was reported to spread via natural aerosols from human-to-human. In the early stages of this epidemic the case fatality rate is estimated to be approximately 2%, with the majority of deaths occurring in special populations. Unfortunately, there is limited experience with coronavirus infections during pregnancy, and it now appears certain that pregnant women have become infected during the present 2019-nCoV epidemic. In order to assess the potential of the Wuhan 2019-nCoV to cause maternal, fetal and neonatal morbidity and other poor obstetrical outcomes, this communication reviews the published data addressing the epidemiological and clinical effects of SARS, MERS, and other coronavirus infections on pregnant women and their infants. Recommendations are also made for the consideration of pregnant women in the design, clinical trials, and implementation of future 2019-nCoV vaccines. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).",2019-nCoV; China; Coronavirus; COVID-19; Emerging infection; Epidemic; Maternal death; Maternal morbidity; Maternal mortality; MERS-CoV; Middle East respiratory syndrome; Pneumonia; Pregnancy; Pregnancy complications; SARS-CoV; SARS-CoV-2; Severe acute respiratory syndrome; Wuhan coronavirus; Wuhan coronavirus outbreak,"2019 novel coronavirus; case fatality rate; coronavirus disease 2019; enzyme immunoassay; epidemic; female; fetus outcome; human; immunofluorescence test; infant; infection prevention; maternal morbidity; maternal mortality; Middle East respiratory syndrome; newborn morbidity; placenta disorder; pneumonia; pregnancy; pregnancy outcome; pregnant woman; prevalence; reverse transcription polymerase chain reaction; Review; safety; severe acute respiratory syndrome; virus transmission; China; Coronavirinae; Coronavirus infection; immunology; maternal exposure; newborn; pathology; placenta; pregnancy; pregnancy complication; severe acute respiratory syndrome; vertical transmission; virus pneumonia; COVID-19; virus vaccine; China; Coronavirus; Coronavirus Infections; Disease Outbreaks; Female; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Maternal Exposure; Placenta; Pneumonia, Viral; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Outcome; Severe Acute Respiratory Syndrome; Viral Vaccines","Hui, D.S., Epidemic and emerging coronaviruses (severe acute respiratory syndrome and Middle East respiratory syndrome) (2017) Clin. 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Rep., 6, pp. 205-212; Steinbuch, Y., Chinese Baby Tests Positive for Coronavirus 30 Hours After Birth, , https://nypost.com/2020/02/05/chinese-baby-tests-positive-for-coronavirus-30-hours-after-birth/, Available online: accessed on 9 February 2020; Woodward, A., A Pregnant Mother Infected with The Coronavirus Gave Birth, and Her Baby Tested Positive 30 Hours Later, , https://www.businessinsider.com/wuhan-coronavirus-in-infant-bornfrom-infected-mother-2020-2, Available online: accessed on 8 February 2020; Gillespie, T., Coronavirus: Doctors Fear Pregnant Women Can Pass on Illness After Newborn Baby Is Diagnosed, , https://news.sky.com/story/coronavirus-doctors-fear-pregnant-women-can-pass-on-illness-after-newborn-baby-is-diagnosed-11926968, Available online: accessed on 8 February 2020; Expert Reaction to Newborn Baby Testing Positive for Coronavirus in Wuhan, , https://www.sciencemediacentre.org/expert-reaction-to-newborn-baby-testing-positivefor-coronavirus-in-wuhan/, Available online: accessed on 9 February 2020; Alvarado, M.G., Schwartz, D.A., Zika virus infection in pregnancy, microcephaly and maternal and fetal health—What we think, what we know, and what we think we know (2017) Arch. Pathol. Lab. Med., 141, pp. 26-32. , CrossRef PubMed","Schwartz, D.A.; Medical College of Georgia, Augusta UniversityUnited States; email: davidalanschwartz@gmail.com",,MDPI AG,19994915,,,32050635,English,Viruses,Review,Final,Open Access,Scopus,2-s2.0-85079335720,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Bonilla-Aldana D.K., Holguin-Rivera Y., Cortes-Bonilla I., Cardona-Trujillo M.C., García-Barco A., Bedoya-Arias H.A., Rabaan A.A., Sah R., Rodriguez-Morales A.J.",57208153819;56671341500;57214794438;57214802845;57211919145;57202419043;56049830800;57195544674;8886801000;,"Coronavirus infections reported by ProMED, February 2000–January 2020",2020,Travel Medicine and Infectious Disease,,,101575,,,,,10.1016/j.tmaid.2020.101575,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079157254&doi=10.1016%2fj.tmaid.2020.101575&partnerID=40&md5=7eedbb5af8b6dc8ddc9b9d2f73969561,"Incubator in Zoonosis (SIZOO), Biodiversity and Ecosystem Conservation Research Group (BIOECOS), Fundación Universitaria Autónoma de las Américas, Sede Pereira, Pereira, Risaralda, Colombia; Public Health and Infection Research Group and Incubator, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia; Infection and Immunity Research Group, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Risaralda 660003, Colombia; Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia; Department of Microbiology, Tribhuvan University Teaching Hospital, Institute of Medicine, Kathmandu, Nepal; Grupo de Investigación Biomedicina, Faculty of Medicine, Fundación Universitaria Autónoma de las Américas, Pereira, Risaralda, Colombia","Bonilla-Aldana, D.K., Incubator in Zoonosis (SIZOO), Biodiversity and Ecosystem Conservation Research Group (BIOECOS), Fundación Universitaria Autónoma de las Américas, Sede Pereira, Pereira, Risaralda, Colombia, Public Health and Infection Research Group and Incubator, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia; Holguin-Rivera, Y., Public Health and Infection Research Group and Incubator, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia; Cortes-Bonilla, I., Public Health and Infection Research Group and Incubator, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia; Cardona-Trujillo, M.C., Public Health and Infection Research Group and Incubator, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia, Infection and Immunity Research Group, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Risaralda 660003, Colombia; García-Barco, A., Public Health and Infection Research Group and Incubator, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia; Bedoya-Arias, H.A., Public Health and Infection Research Group and Incubator, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia; Rabaan, A.A., Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia; Sah, R., Department of Microbiology, Tribhuvan University Teaching Hospital, Institute of Medicine, Kathmandu, Nepal; Rodriguez-Morales, A.J., Public Health and Infection Research Group and Incubator, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia, Grupo de Investigación Biomedicina, Faculty of Medicine, Fundación Universitaria Autónoma de las Américas, Pereira, Risaralda, Colombia","Introduction: Sources describing the global burden of emerging diseases accurately are still limited. We reviewed coronavirus infections reported by ProMED and assessed the reliability of the data retrieved compared to published reports. We evaluated the effectiveness of ProMED as a source of epidemiological data on coronavirus. Methods: Using the keyword “coronavirus” in the ProMED search engine, we reviewed all the information from the reports and collected data using a structured form, including year, country, gender, occupation, the number of infected individuals, and the number of fatal cases. Results: We identified 109 entries reported between February 29, 2000 and January 22, 2020. A total of 966 cases were reported, with death reported in 188 cases, suggesting an overall case fatality rate (CFR) of 19.5%. Of 70 cases for which the gender was reported, 47 (67.1%) were male. Most of the cases were reported from China, the United Arab Emirates, and Saudi Arabia, with reports from other countries, including imported cases in Europe and North America. Conclusions: Internet-based reporting systems such as ProMED are useful to gather information and synthesize knowledge on emerging infections. Although certain areas need to be improved, ProMED provided useful information about coronaviruses especially during outbreaks. © 2020 Elsevier Ltd",Coronavirus; Epidemiology; Outbreak; ProMED,,"Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet; Li, G., Fan, Y., Lai, Y., Han, T., Li, Z., Zhou, P., Coronavirus infections and immune responses (2020) J Med Virol; Al-Tawfiq, J.A., Zumla, A., Memish, Z.A., Travel implications of emerging coronaviruses: SARS and MERS-CoV (2014) Trav Med Infect Dis, 12, pp. 422-428; Wilder-Smith, A., The severe acute respiratory syndrome: impact on travel and tourism (2006) Trav Med Infect Dis, 4, pp. 53-60; Ksiazek, T.G., Erdman, D., Goldsmith, C.S., Zaki, S.R., Peret, T., Emery, S., A novel coronavirus associated with severe acute respiratory syndrome (2003) N Engl J Med, 348, pp. 1953-1966; Kuiken, T., Fouchier, R.A., Schutten, M., Rimmelzwaan, G.F., van Amerongen, G., van Riel, D., Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome (2003) Lancet, 362, pp. 263-270; Drosten, C., Gunther, S., Preiser, W., van der Werf, S., Brodt, H.R., Becker, S., Identification of a novel coronavirus in patients with severe acute respiratory syndrome (2003) N Engl J Med, 348, pp. 1967-1976; Al-Tawfiq, J.A., Gautret, P., Asymptomatic Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection: extent and implications for infection control: a systematic review (2019) Trav Med Infect Dis, 27, pp. 27-32; Baharoon, S., Memish, Z.A., MERS-CoV as an emerging respiratory illness: a review of prevention methods (2019) Trav Med Infect Dis, p. 101520; de Groot, R.J., Baker, S.C., Baric, R.S., Brown, C.S., Drosten, C., Enjuanes, L., Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group (2013) J Virol, 87, pp. 7790-7792; Zaki, A.M., van Boheemen, S., Bestebroer, T.M., Osterhaus, A.D., Fouchier, R.A., Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia (2012) N Engl J Med, 367, pp. 1814-1820; List of Blueprint priority diseases (2018), https://www.who.int/docs/default-source/blue-print/2018-annual-review-of-diseases-prioritized-under-the-research-and-development-blueprint.pdf?sfvrsn=4c22e36_2, WHO; World Health Organization, Statement on the second meeting of the International Health Regulations (2005) Emergency Committee regarding the outbreak of novel coronavirus (2019-nCoV) (2020), https://www.who.int/news-room/detail/30-01-2020-statement-on-the-second-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-outbreak-of-novel-coronavirus-(2019-ncov; World Health Organization, Novel coronavirus (2019-nCoV) - situation report - 10 - 30 January 2020 (2020), https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200130-sitrep-10-ncov.pdf?sfvrsn=d0b2e480_2; Ince, Y., Yasa, C., Metin, M., Sonmez, M., Meram, E., Benkli, B., Crimean-Congo hemorrhagic fever infections reported by ProMED (2014) Int J Infect Dis : IJID : official publication of the International Society for Infectious Diseases, 26, pp. 44-46; Madoff, L.C., ProMED-mail: an early warning system for emerging diseases (2004) Clin Infect Dis : an official publication of the Infectious Diseases Society of America, 39, pp. 227-232; Madoff, L.C., Woodall, J.P., The internet and the global monitoring of emerging diseases: lessons from the first 10 years of ProMED-mail (2005) Arch Med Res, 36, pp. 724-730; Rolland, C., Lazarus, C., Giese, C., Monate, B., Travert, A.S., Salomon, J., Early detection of public health emergencies of international concern through undiagnosed disease reports in ProMED-mail (2020) Emerg Infect Dis, 26, pp. 336-339; Carrion, M., Madoff, L.C., ProMED-mail: 22 years of digital surveillance of emerging infectious diseases (2017) Int Health, 9, pp. 177-183; Desai, A.N., Anyoha, A., Madoff, L.C., Lassmann, B., Changing epidemiology of Listeria monocytogenes outbreaks, sporadic cases, and recalls globally: a review of ProMED reports from 1996 to 2018 (2019) Int J Infect Dis, 84, pp. 48-53; ProMED, About ProMED-mail (2014), https://promedmail.org/about-promed/; ProMED, About ProMED-mail (2020), https://promedmail.org/about-promed/; Nasner-Posso, K.M., Cruz-Calderon, S., Montufar-Andrade, F.E., Dance, D.A., Rodriguez-Morales, A.J., Human melioidosis reported by ProMED (2015) Int J Infect Dis, 35, pp. 103-106; Pollack, M.P., Pringle, C., Madoff, L.C., Memish, Z.A., Latest outbreak news from ProMED-mail: novel coronavirus -- Middle East (2013) Int J Infect Dis : IJID : official publication of the International Society for Infectious Diseases, 17, pp. e143-e144; Cui, J., Li, F., Shi, Z.L., Origin and evolution of pathogenic coronaviruses (2019) Nat Rev Microbiol, 17, pp. 181-192; Bonilla-Aldana, D.K., Quintero-Rada, K., Montoya-Posada, J.P., Ramirez, S., Paniz-Mondolfi, A., Rabaan, A., SARS-CoV, MERS-CoV and now the 2019-novel CoV: have we investigated enough about coronaviruses? - a bibliometric analysis (2020) Trav Med Infect Dis, p. 101566; Chan, J.F.-W., Yuan, S., Kok, K.-H., To, K.K.-W., Chu, H., Yang, J., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet; Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet; Phan, L.T., Nguyen, T.V., Luong, Q.C., Nguyen, T.V., Nguyen, H.T., Le, H.Q., Importation and human-to-human transmission of a novel coronavirus in Vietnam (2020) N Engl J Med; Rothe, C., Schunk, M., Sothmann, P., Bretzel, G., Froeschl, G., Wallrauch, C., Transmission of 2019-nCoV infection from an asymptomatic contact in Germany (2020) N Engl J Med; Gallego, V., Berberian, G., Lloveras, S., Verbanaz, S., Chaves, T.S., Orduna, T., The 2014 FIFA World Cup: communicable disease risks and advice for visitors to Brazil--a review from the Latin American Society for Travel Medicine (SLAMVI) (2014) Trav Med Infect Dis, 12, pp. 208-218; Ji, W., Wang, W., Zhao, X., Zai, J., Li, X., Homologous recombination within the spike glycoprotein of the newly identified coronavirus may boost cross-species transmission from snake to human (2020) J Med Virol; Lau, S.K.P., Li, K.S.M., Luk, H.K.H., He, Z., Teng, J.L.L., Yuen, K.Y., Middle East respiratory syndrome coronavirus antibodies in bactrian and hybrid camels from dubai (2020) mSphere, 5; Liu, S.L., Saif, L., Emerging viruses without borders: the Wuhan coronavirus (2020) Viruses, 12; Rubin, E.J., Baden, L.R., Morrissey, S., Campion, E.W., Medical journals and the 2019-nCoV outbreak (2020) N Engl J Med; The, L., Emerging understandings of 2019-nCoV (2020) Lancet, 395, p. 311; Veljkovic, V., Vergara-Alert, J., Segalés, J., Paessler, S., Use of the informational spectrum methodology for rapid biological analysis of the novel coronavirus 2019-nCoV: prediction of potential receptor, natural reservoir, tropism and therapeutic/vaccine target [version 2; peer review: awaiting peer review] (2020) F1000Research, 9","Rodriguez-Morales, A.J.; Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnológica de PereiraColombia; email: arodriguezm@utp.edu.co",,Elsevier USA,14778939,,TMIDA,32036011,English,Travel Med. Infect. Dis.,Article,Article in Press,Open Access,Scopus,2-s2.0-85079157254,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Seah I., Agrawal R.",57207488682;7201475180;,Can the Coronavirus Disease 2019 (COVID-19) Affect the Eyes? A Review of Coronaviruses and Ocular Implications in Humans and Animals,2020,Ocular Immunology and Inflammation,,,,,,,,10.1080/09273948.2020.1738501,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081727104&doi=10.1080%2f09273948.2020.1738501&partnerID=40&md5=3e5b41d9bbfb94d3fc7645e10d6a78c5,"Department of Ophthalmology, National University Hospital, Singapore, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; NHS Foundation Trust, Moorfields Eye Hospital, London, United Kingdom; National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore","Seah, I., Department of Ophthalmology, National University Hospital, Singapore, Singapore; Agrawal, R., Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore, NHS Foundation Trust, Moorfields Eye Hospital, London, United Kingdom, National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore, Singapore","In December 2019, a novel coronavirus (CoV) epidemic, caused by the severe acute respiratory syndrome coronavirus–2 (SARS-CoV-2) emerged from China. This virus causes the coronavirus disease 2019 (COVID-19). Since then, there have been anecdotal reports of ocular infection. The ocular implications of human CoV infections have not been widely studied. However, CoVs have been known to cause various ocular infections in animals. Clinical entities such as conjunctivitis, anterior uveitis, retinitis, and optic neuritis have been documented in feline and murine models. In this article, the current evidence suggesting possible human CoV infection of ocular tissue is reviewed. The review article will also highlight animal CoVs and their associated ocular infections. We hope that this article will serve as a start for further research into the ocular implications of human CoV infections. © 2020, © 2020 Taylor & Francis Group, LLC.",Coronavirus; coronavirus disease 2019; COVID-19; novel coronavirus; severe acute respiratory syndrome coronavirus-2,,"Salata, C., Calistri, A., Parolin, C., Palu, G., Coronaviruses: a paradigm of new emerging zoonotic diseases (2020) Pathog Dis, , 77(9; Loon, S.C., Lun, K., SARS: a timely reminder (2013) Br J Ophthalmol, 97 (9), pp. 1217-1218; Summary table of SARS cases by country, 1 November 2002-7 August 2003 (2003) Summary Table of SARS Cases by Country N-A, , World Health Organisation (WHO),. Geneva (Switzerland; Chafekar, A., Fielding, B.C., MERS-CoV: understanding the latest human coronavirus threat (2018) Viruses, 10 (2). , 93; (2020) Coronavirus disease 2019 (COVID-19) situation report 32, , https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200221-sitrep-32-covid-19.pdf; (2020) Statement on the second meeting of the international health regulations (2005) emergency committee regarding the outbreak of novel coronavirus (2019-nCoV), , https://www.who.int/news-room/detail/30-01-2020-statement-on-the-second-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-outbreak-of-novel-coronavirus-(2019-ncov; (2020) Infection prevention and control during health care when novel coronavirus (nCoV) infection is suspected, , https://www.who.int/publications-detail/infection-prevention-and-control-during-health-care-when-novel-coronavirus-(ncov)-infection-is-suspected-20200125; Madhugiri, R., Fricke, M., Marz, M., Ziebuhr, J., Coronavirus cis-acting RNA elements (2016) Adv Virus Res, 96, pp. 127-163; Chen, Y., Liu, Q., Guo, D., Coronaviruses: genome structure, replication, and pathogenesis J Med Virol, , 2020;92:418–423; Tekes, G., Thiel, H.J., Feline coronaviruses: pathogenesis of feline infectious peritonitis (2016) Adv Virus Res, 96, pp. 193-218; van Nguyen, D., Terada, Y., Minami, S., Characterization of canine coronavirus spread among domestic dogs in Vietnam (2017) J Vet Med Sci, 79 (2), pp. 343-349; Mihindukulasuriya, K.A., Wu, G., St Leger, J., Nordhausen, R.W., Wang, D., Identification of a novel coronavirus from a beluga whale by using a panviral microarray (2008) J Virol, 82 (10), pp. 5084-5088; Woo, P.C., Lau, S.K., Huang, Y., Yuen, K.Y., Coronavirus diversity, phylogeny and interspecies jumping (2009) Exp Biol Med (Maywood), 234 (10), pp. 1117-1127; Cui, J., Li, F., Shi, Z.L., Origin and evolution of pathogenic coronaviruses (2019) Nat Rev Microbiol, 17 (3), pp. 181-192; Corman, V.M., Muth, D., Niemeyer, D., Drosten, C., Hosts and sources of endemic human coronaviruses (2018) Adv Virus Res, 100, pp. 163-188; Vassilara, F., Spyridaki, A., Pothitos, G., Deliveliotou, A., Papadopoulos, A., A rare case of human coronavirus 229E associated with acute respiratory distress syndrome in a healthy adult (2018) Case Rep Infect Dis, 2018, p. 6796839; Gralinski, L.E., Baric, R.S., Molecular pathology of emerging coronavirus infections (2015) J Pathol, 235 (2), pp. 185-195; Loon, S.-C., Teoh, S.C.B., Oon, L.L.E., The severe acute respiratory syndrome coronavirus in tears (2004) British J Ophthalmol, 88 (7), pp. 861-863; Yeo, C., Kaushal, S., Yeo, D., Enteric involvement of coronaviruses: is faecal & oral transmission of SARS-CoV-2 possible? Lancet Gastroenterol Hepatol, , 2020. epub ahead of print; Hung, L.S., The SARS epidemic in Hong Kong: what lessons have we learned? (2003) J R Soc Med, 96 (8), pp. 374-378; Wang, X.W., Li, J., Guo, T., Concentration and detection of SARS coronavirus in sewage from Xiao Tang Shan hospital and the 309th hospital of the Chinese people’s liberation army (2005) Water Sci Technol, 52 (8), pp. 213-221; Zhang, W., Du, R.H., Li, B., Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes (2020) Emerg Microbes Infect, 9 (1), pp. 386-389; van der Hoek, L., Pyrc, K., Jebbink, M.F., Identification of a new human coronavirus (2004) Nat Med, 10 (4), pp. 368-373; Vabret, A., Mourez, T., Dina, J., Human coronavirus NL63, France (2005) Emerg Infect Dis, 11 (8), pp. 1225-1229; Tong, T., Lai, T.S., The severe acute respiratory syndrome coronavirus in tears (2005) Br J Ophthalmol, 89 (3), p. 392; Chan, W.M., Yuen, K.S., Fan, D.S., Lam, D.S., Chan, P.K., Sung, J.J., Tears and conjunctival scrapings for coronavirus in patients with SARS (2004) Br J Ophthalmol, 88 (7), pp. 968-969; Yan, A., (2020) Chinese expert who came down with Wuhan coronavirus after saying it was controllable thinks he was infected through his eyes China: South China morning post, , https://www.scmp.com/news/china/article/3047394/chinese-expert-who-came-down-wuhan-coronavirus-after-saying-it-was; Lu, C.W., Liu, X.F., Jia, Z.F., 2019-nCoV transmission through the ocular surface must not be ignored (2020) Lancet, 395 (10224), p. e39; Seah, I., Su, X., Lingam, G., Revisiting the dangers of the coronavirus in the ophthalmology practice (2020) Eye (Lond); Wan, Y., Shang, J., Graham, R., Baric, R.S., Li, F., Receptor recognition by novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS (2020) J Virol, , epub ahead of print; Holappa, M., Vapaatalo, H., Vaajanen, A., Many faces of renin-angiotensin system - focus on eye (2017) Open Ophthalmol J, 11 (1), pp. 122-142; Hohdatsu, T., Okada, S., Ishizuka, Y., Yamada, H., Koyama, H., The prevalence of types I and II feline coronavirus infections in cats (1992) J Vet Med Sci, 54 (3), pp. 557-562; Pedersen, N.C., Boyle, J.F., Floyd, K., Fudge, A., Barker, J., An enteric coronavirus infection of cats and its relationship to feline infectious peritonitis (1981) Am J Vet Res, 42, pp. 368-377; Jaimes, J.A., Whittaker, G.R., Feline coronavirus: insights into viral pathogenesis based on the spike protein structure and function (2018) Virology, 517, pp. 108-121; Chang, H.W., Egberink, H.F., Rottier, P.J., Sequence analysis of feline coronaviruses and the circulating virulent/avirulent theory (2011) Emerg Infect Dis, 17 (4), pp. 744-746; Pedersen, N.C., Liu, H., Scarlett, J., Feline infectious peritonitis: role of the feline coronavirus 3c gene in intestinal tropism and pathogenicity based upon isolates from resident and adopted shelter cats (2012) Virus Res, 165 (1), pp. 17-28; Kipar, A., May, H., Menger, S., Weber, M., Leukert, W., Reinacher, M., Morphologic features and development of granulomatous vasculitis in feline infectious peritonitis (2005) Vet Pathol, 42 (3), pp. 321-330; de Groot-mijnes, J.D., van Dun, J.M., van der Most, R.G., de Groot, R.J., Natural history of a recurrent feline coronavirus infection and the role of cellular immunity in survival and disease (2005) J Virol, 79 (2), pp. 1036-1044; Hok, K., Morbidity, mortality and coronavirus antigen in previously coronavirus free kittens placed in two catteries with feline infectious peritonitis (1993) Acta Vet Scand, 34, pp. 203-210; Doherty, M.J., Ocular manifestations of feline infectious peritonitis (1971) J Am Vet Med Assoc, 159, pp. 417-424; Homberger, F.R., Zhang, L., Barthold, S.W., Prevalence of enterotropic and polytropic mouse hepatitis virus in enzootically infected mouse colonies (1998) Lab Anim Sci, 48, pp. 50-54; Bailey, O.T., Pappenheimer, A.M., Cheever, F.S., Daniels, J.B., A murine virus (JHM) causing disseminated encephalomyelitis with extensive destruction of myelin: II. Pathology (1949) J Exp Med, 90 (3), pp. 195-212; Dick, G.W., Niven, J.S., Gledhill, A.W., A virus related to that causing hepatitis in mice (MHV) (1956) Br J Exp Pathol, 37, pp. 90-98; De Albuquerque, N., Baig, E., Ma, X., Murine hepatitis virus strain 1 produces a clinically relevant model of severe acute respiratory syndrome in A/J mice (2006) J Virol, 80 (21), pp. 10382-10394; Williams, R.K., Jiang, G.S., Holmes, K.V., Receptor for mouse hepatitis virus is a member of the carcinoembryonic antigen family of glycoproteins (1991) Proc Natl Acad Sci USA, 88 (13), pp. 5533-5536; Nakagaki, K., Nakagaki, K., Taguchi, F., Receptor-independent spread of a highly neurotropic murine coronavirus JHMV strain from initially infected microglial cells in mixed neural cultures (2005) J Virol, 79 (10), pp. 6102-6110; Manaker, R.A., Piczak, C.V., Miller, A.A., Stanton, M.F., A hepatitis virus complicating studies with mouse leukemia (1961) J Natl Cancer Inst, 27, pp. 29-51; Robbins, S.G., Detrick, B., Hooks, J.J., Retinopathy following intravitreal injection of mice with MHV strain JHM (1990) Adv Exp Med Biol, 276, pp. 519-524; Hooks, J.J., Percopo, C., Wang, Y., Detrick, B., Retina and retinal pigment epithelial cell autoantibodies are produced during murine coronavirus retinopathy (1993) J Immunol, 151, pp. 3381-3389; Shindler, K.S., Kenyon, L.C., Dutt, M., Hingley, S.T., Das Sarma, J., Experimental optic neuritis induced by a demyelinating strain of mouse hepatitis virus (2008) J Virol, 82 (17), pp. 8882-8886","Agrawal, R.; National Healthcare Group Eye Institute, Tan Tock Seng Hospital, 11, Jalan Tan Tock SengSingapore; email: Rupesh_agrawal@ttsh.com.sg",,Taylor and Francis Ltd,9273948,,OIINE,,English,Ocul. Immunol. Inflamm.,Review,Article in Press,Open Access,Scopus,2-s2.0-85081727104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Tian S., Hu W., Niu L., Liu H., Xu H., Xiao S.-Y.",7202367443;36659378100;57215782015;57205385074;57214776130;13310234300;,Pulmonary Pathology of Early-Phase 2019 Novel Coronavirus (COVID-19) Pneumonia in Two Patients With Lung Cancer,2020,Journal of Thoracic Oncology,,,,,,,4,10.1016/j.jtho.2020.02.010,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081667424&doi=10.1016%2fj.jtho.2020.02.010&partnerID=40&md5=d2ccf24a4e0f73bfb5debf718b6d641c,"Department of Pathology, Zhongnan Hospital of Wuhan University, Wuhan, China; Department of Thoracic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China; Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China; Department of Pathology, University of Chicago Medicine, Chicago, IL, United States","Tian, S., Department of Pathology, Zhongnan Hospital of Wuhan University, Wuhan, China; Hu, W., Department of Thoracic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China; Niu, L., Department of Pathology, Zhongnan Hospital of Wuhan University, Wuhan, China; Liu, H., Department of Pathology, Zhongnan Hospital of Wuhan University, Wuhan, China; Xu, H., Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China; Xiao, S.-Y., Department of Pathology, Zhongnan Hospital of Wuhan University, Wuhan, China, Department of Pathology, University of Chicago Medicine, Chicago, IL, United States","There is currently a lack of pathologic data on the novel coronavirus (severe acute respiratory syndrome coronavirus 2) pneumonia, or coronavirus disease 2019 (COVID-19), from autopsy or biopsy. Two patients who recently underwent lung lobectomies for adenocarcinoma were retrospectively found to have had COVID-19 at the time of the operation. These two cases thus provide important first opportunities to study the pathology of COVID-19. Pathologic examinations revealed that apart from the tumors, the lungs of both patients exhibited edema, proteinaceous exudate, focal reactive hyperplasia of pneumocytes with patchy inflammatory cellular infiltration, and multinucleated giant cells. Hyaline membranes were not prominent. Because both patients did not exhibit symptoms of pneumonia at the time of operation, these changes likely represent an early phase of the lung pathology of COVID-19 pneumonia. © 2020 International Association for the Study of Lung Cancer",Coronavirus; COVID-19 pneumonia; Pathology; SARS-CoV-2,,"Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506; Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382, pp. 727-733; Wang, D., Hu, B., Hu, C., (2020), Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China [e-pub ahead of print]. JAMA., accessed February 7; Hwang, D.M., Chamberlain, D.W., Poutanen, S.M., Low, D.E., Asa, S.L., Butany, J., Pulmonary pathology of severe acute respiratory syndrome in Toronto (2005) Mod Pathol, 18, pp. 1-10; Franks, T.J., Chong, P.Y., Chui, P., Lung pathology of severe acute respiratory syndrome (SARS): a study of 8 autopsy cases from Singapore (2003) Hum Pathol, 34, pp. 743-748; Nicholls, J.M., Poon, L.L., Lee, K.C., Lung pathology of fatal severe acute respiratory syndrome (2003) Lancet, 361, pp. 1773-1778; Xiao, S.Y., Wu, Y., Liu, H., (2020), Evolving status of the 2019 novel coronavirus infection: proposal of conventional serologic assays for disease diagnosis and infection monitoring [e-pub ahead of print]. J Med Virol., accessed February 7","Xiao, S.-Y.; Department of Pathology, Zhongnan Hospital of Wuhan Universityemail: syxiao@uchicago.edu",,Elsevier Inc,15560864,,,32114094,English,J. Thorac. Oncol.,Article,Article in Press,Open Access,Scopus,2-s2.0-85081667424,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Leung C.,57209301345;,Clinical features of deaths in the novel coronavirus epidemic in China,2020,Reviews in Medical Virology,,,,,,,,10.1002/rmv.2103,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081639765&doi=10.1002%2frmv.2103&partnerID=40&md5=3a147a02a07419c155c81d119b092de8,"Deakin University, Melbourne, VIC, Australia","Leung, C., Deakin University, Melbourne, VIC, Australia","In response to the recent novel coronavirus outbreak originating in Wuhan, Hubei province, China, observations concerning novel coronavirus mortality are of urgent public health importance. The present work presents the first review of the fatal novel coronavirus cases in China. Clinical data of fatal cases published by the Chinese Government were studied. As of 2 February 2020, the clinical data of 46 fatal cases were identified. The case fatality rate was significantly higher in Hubei province than the rest of China. While 67% of all deceased patients were male, gender was unlikely to be associated with mortality. Diabetes was likely to be associated with mortality. There is, however, not yet sufficient evidence to support the association between hypertension and mortality as similar prevalence of hypertension was also observed in the Hubei population. © 2020 John Wiley & Sons, Ltd",mortality; novel coronavirus; Wuhan pneumonia,,"Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382, pp. 727-733. , https://doi.org/10.1056/NEJMoa2001017; http://www.nhc.gov.cn/xwzb/webcontroller.do?titleSeq=11209&gecstype=1, State Council Information Office Press Conference., Accessed February 3, 2020; Ji, W., Wang, W., Zhao, X., Zai, J., Li, X., Homologous recombination within the spike glycoprotein of the newly identified coronavirus may boost cross-species transmission from snake to human (2020) J Med Virol, 92, pp. 433-440. , https://doi.org/10.1002/jmv.25682; http://www.nhc.gov.cn/xcs/yqtb/202001/1beb46f061704372b7ca41ef3e682229.shtml, Wuhan Municipal Health Commission's report on viral pneumonia with unknown etiology., Accessed February 3, 2020; http://wjw.hubei.gov.cn/fbjd/dtyw/202001/t20200124_2014626.shtml, Hubei Province Health Commission's report on pneumonia of new coronavirus infection, 2020., Accessed February 3, 2020; http://wjw.hubei.gov.cn/fbjd/dtyw/202001/t20200125_2014854.shtml, Hubei Province Health Commission's report on pneumonia of new coronavirus infection, 2020., Accessed February 3, 2020; http://www.nhc.gov.cn/xcs/yqtb/202001/5d19a4f6d3154b9fae328918ed2e3c8a.shtml, Epidemic situation of the new coronavirus infection on January 23., Accessed February 3, 2020; http://cq.cqnews.net/jrzb2/col607342.htm, Seventh routine news briefing on pneumonia prevention and control of new coronavirus infection., Accessed February 3, 2020; http://www.ha.xinhuanet.com/news/2020-01/31/c_1125515584.htm, Press conference on the new coronavirus epidemic prevention and control., Accessed February 3, 2020; http://www.gov.cn/xinwen/2020-02/01/content_5473540.htm, Heilongjiang open and transparent to the public and the initiative to fight the epidemic., Accessed February 3, 2020; http://www.hebwst.gov.cn/index.do?id=394918&templet=content&cid=45, The second case of new coronavirus pneumonia confirmed in our province., Accessed February 3, 2020; http://cdwjw.chengdu.gov.cn/cdwjw/gzdt/2020-01/30/content_516b4576ecc74698b88344d133dd211e.shtml, Thirteen new coronavirus pneumonia cases in Chengdu., Accessed February 3, 2020; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506. , https://doi.org/10.1016/s0140-6736(20)30183-5; Hui, D.S., Azhar, E.I., Madani, T.A., The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health—the latest 2019 novel coronavirus outbreak in Wuhan, China (2020) Int J Infect Dis, 91, pp. 264-266. , https://doi.org/10.1016/j.ijid.2020.01.009; Wang, D., Hu, B., Hu, C., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) JAMA, , https://doi.org/10.1001/jama.2020; Yu, C.H., Yuan, R.X., Bao, J.Z., Zhang, Q.J., Risk factors for hypertension and diabetes among floating population in Hubei Province: a cross-section survey (2016) Chin J Evidence-Based Med, 16 (8), pp. 891-896. , https://doi.org/10.7507/1672-2531.20160138","Leung, C.; Deakin UniversityAustralia; email: char.leung@deakin.edu.au",,John Wiley and Sons Ltd,10529276,,RMVIE,,English,Rev. Med. Virol.,Review,Article in Press,Open Access,Scopus,2-s2.0-85081639765,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Henwood A.F.,6603040517;,Coronavirus disinfection in histopathology,2020,Journal of Histotechnology,,,,,,,,10.1080/01478885.2020.1734718,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081257852&doi=10.1080%2f01478885.2020.1734718&partnerID=40&md5=dc54aea50f131a1a59292bb7b94e9524,"Histopathology Department, The Children’s Hospital at Westmead, Sydney, Australia; School of Medicine, University of Western Sydney, Sydney, Australia","Henwood, A.F., Histopathology Department, The Children’s Hospital at Westmead, Sydney, Australia, School of Medicine, University of Western Sydney, Sydney, Australia","The 2019 Coronavirus epidemic, provisionally called 2019-nCoV, was first identified in Wuhan, China, in persons exposed to a seafood or wet market. There is an international push to contain the virus and prevent its spread. It is feasible that potentially infectious samples may be received in histopathology laboratories for diagnosis. This technical note presents disinfection procedures and histotechnology processes that should alleviate the risk of infection to laboratory staff. Using data obtained from similar coronaviruses, e.g. severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), experts are confident that 70% ethanol and 0.1% sodium hypochlorite should inactivate the virus. Formalin fixation and heating samples to 56oC, as used in routine tissue processing, were found to inactivate several coronaviruses and it is believed that 2019-nCoV would be similarly affected. © 2020, © 2020 National Society for Histotechnology.",biosafety; Coronavirus; disinfection; histopathology laboratory; histotechnology; SARS-CoV-2,,"Xu, Z., Shi, L., Wang, Y., Pathological findings of COVID-19 associated with acute respiratory distress syndrome (2020) Lancet Respir Med, , published online Feb 17; Guarner, J., Three emerging Coronaviruses in two decades the story of SARS, MERS, and now COVID-19 (2020) Editorial Am J Clin Pathol, , Feb, 13; Gorbalenya, A.E., Severe acute respiratory syndrome-related coronavirus–The species and its viruses, a statement of the Coronavirus Study Group (2020) bioRxiv, , Jan, 1; (2020) Infection prevention and control during health care when novel coronavirus (‎‎‎nCoV)‎‎‎ infection is suspected: interim guidance, 25 January 2020, , https://www.who.int/publications-detail/infection-prevention-and-control-during-health-care-when-novel-coronavirus-(ncov)-infection-is-suspected-20200125, World Health Organization, 1-5; Perlman, S., Another decade, another coronavirus (2020) N Engl J Med, 382, pp. 760-762. , Jan, 24; Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China (2019) N Engl J Med, , 2019.,. Feb 20,. 382:727–733; Paules, C.I., Marston, H.D., Fauci, A.S., Coronavirus infections—more than just the common cold (2020) JAMA, , Jan, 23; Henwood, A., (2019) A survival guide for laboratory professionals, pp. 149-155. , Scotts Valley, CA, USA: Amazon Create Space Independent Publishing Platform, Chapter 18 Disinfection; Kampf, G., Todt, D., Pfaender, S., Persistence of coronaviruses on inanimate surfaces and its inactivation with biocidal agents (2020) J Hosp Infect; Duan, S.M., Zhao, X.S., Wen, R.F., Stability of SARS coronavirus in human specimens and environment and its sensitivity to heating and UV irradiation (2003) Biomed Environ Sci, 16 (3), pp. 246-255. , Sep; Henwood, A.F., Ebola and histotechnologists (2018) J Histotechnology, 41 (2), pp. 71-73. , Apr, 3; Darnell, M.E., Subbarao, K., Feinstone, S.M., Inactivation of the coronavirus that induces severe acute respiratory syndrome, SARS-CoV (2004) J Virol Methods, 121 (1), pp. 85-91. , Oct, 1","Henwood, A.F.; Histopathology Department, The Children’s Hospital at WestmeadAustralia; email: tony.henwood@health.nsw.gov.au",,Taylor and Francis Ltd.,1478885,,JOHID,32116147,English,J. Histotechnol.,Article,Article in Press,,Scopus,2-s2.0-85081257852,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Riou J., Althaus C.L.",56622387500;8890140100;,"Pattern of early human-to-human transmission of Wuhan 2019 novel coronavirus (2019-nCoV), December 2019 to January 2020",2020,Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin,25,4,,,,,16,10.2807/1560-7917.ES.2020.25.4.2000058,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078964053&doi=10.2807%2f1560-7917.ES.2020.25.4.2000058&partnerID=40&md5=0424240d550831a453f8838e4f3228a8,"Institute of Social and Preventive Medicine, University of BernBern, Switzerland","Riou, J., Institute of Social and Preventive Medicine, University of BernBern, Switzerland; Althaus, C.L., Institute of Social and Preventive Medicine, University of BernBern, Switzerland","Since December 2019, China has been experiencing a large outbreak of a novel coronavirus (2019-nCoV) which can cause respiratory disease and severe pneumonia. We estimated the basic reproduction number R0 of 2019-nCoV to be around 2.2 (90% high density interval: 1.4-3.8), indicating the potential for sustained human-to-human transmission. Transmission characteristics appear to be of similar magnitude to severe acute respiratory syndrome-related coronavirus (SARS-CoV) and pandemic influenza, indicating a risk of global spread.",2019-nCoV; coronavirus; emerging infectious disease; mathematical modelling; Wuhan,"COVID-19; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; China; Coronavirus infection; epidemic; global health; human; infection control; influenza; Influenza A virus; pandemic; pathogenicity; risk; SARS coronavirus; severe acute respiratory syndrome; virus pneumonia; virus replication; Betacoronavirus; China; Coronavirus Infections; Disease Outbreaks; Global Health; Humans; Infection Control; Influenza A virus; Influenza, Human; Pandemics; Pneumonia, Viral; Risk; SARS Virus; Severe Acute Respiratory Syndrome; Virus Replication",,,,NLM (Medline),15607917,,,32019669,English,Euro Surveill.,Article,Final,Open Access,Scopus,2-s2.0-85078964053,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wen J., Aston J., Liu X., Ying T.",57196723257;57209909209;57215023558;14625830600;,Effects of misleading media coverage on public health crisis: a case of the 2019 novel coronavirus outbreak in China,2020,Anatolia,,,,,,,3,10.1080/13032917.2020.1730621,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079719906&doi=10.1080%2f13032917.2020.1730621&partnerID=40&md5=a504bba26880c35574493c09caa33123,"School of Business and Law, Edith Cowan University, Perth, Australia; College of Tourism, Sichuan University, Chengdu, China; Department of Tourism and Hotel Management, Schools of Management, Zhejiang University, Hangzhou, China","Wen, J., School of Business and Law, Edith Cowan University, Perth, Australia; Aston, J., School of Business and Law, Edith Cowan University, Perth, Australia; Liu, X., College of Tourism, Sichuan University, Chengdu, China; Ying, T., Department of Tourism and Hotel Management, Schools of Management, Zhejiang University, Hangzhou, China","The coronavirus outbreak in Wuhan, China has sparked a global epidemic, which the World Health Organization declared a public health emergency of international concern on 31st January 2020 (Beijing time). This crisis has attracted intense media attention. Recently, some media outlets inappropriately labelled the coronavirus by race, using such headlines as “Chinese virus pandemonium” and even suggesting “China kids stay home.” The biased and misleading coverage presented via Western media channels has incited anger throughout the Chinese community and has placed undue stress upon Chinese individuals living outside China. This post-published review takes a tourism-focused perspective to examine findings from a quantitative study (Rodriguez-Seijas, Stohl, Hasin, & Eaton, 2015) published in 2015 in JAMA Psychiatry. The current paper highlights the potential impacts of misleading and biased media coverage on Chinese individuals’ mental health. Specifically, this work considers perceived racial discrimination stemming from coronavirus as a public health crisis and the effects of such discrimination on individuals of Chinese heritage. Similarly imperative are pertinent effects on country image and destination image with respect to tourism marketing and tourist behaviour during times of crisis. By considering racism in the context of the coronavirus outbreak, this paper identifies potential avenues for relevant research in tourism and hospitality. © 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group.",country image; destination image; mental disorders; Misleading media coverage; public health crisis; racial discrimination,,"(2020) Coronavirus is a public health emergency: World Health Organization declares, , https://www.abc.net.au/news/2020-01-31/who-coronavirus-global-emergency/11916276, Retrieved from; Aguilera, J., Xenophobia is a pre-existing condition. How harmful stereotypes and racism are spreading around the coronavirus (2020) TIME, , https://time.com/5775716/xenophobia-racism-stereotypes-coronavirus/, Retrieved from; Allport, G., (1954) The nature of prejudice, , Boston, MA: Beacon Press; (2020) Explainer: Seven ways the coronavirus affects human rights, , https://www.amnesty.org/en/latest/news/2020/02/explainer-seven-ways-the-coronavirus-affects-human-rights/, Retrieved from; Brewster, Z., Racially discriminatory service in full-service restaurants: The problem, cause, and potential solutions (2012) Cornell Hotel and Restaurant Administration Quarterly, 53 (4), pp. 274-285; Brewster, Z., Lynn, M., Black–white earnings gap among restaurant servers: A replication, extension, and exploration of consumer racial discrimination in tipping (2014) Sociological Inquiry, 84 (4), pp. 545-569; Carter, R., Lau, M., Johnson, V., Kirkinis, K., Racial discrimination and health outcomes among racial/ethnic minorities: A meta-analytic review (2017) Journal of Multicultural Counseling and Development, 45, pp. 232-259; (2020) Leishenshan Hospital ready to receive patients, , http://www.chinadaily.com.cn/a/202002/08/WS5e3e7810a310128217275fb3.html, Retrieved from; (2020) Huoshenshan Hospital now treating novel coronavirus patients, , https://www.chinadaily.com.cn/a/202002/04/WS5e398cefa310128217274deb.html, Retrieved from; (2020) Cabin hospital offers refuge for mild cases, , http://www.chinadaily.com.cn/a/202002/07/WS5e3cbc27a310128217275ad6.html, Retrieved from; (2020) 1,230 medical workers to assist Wuhan amid coronavirus epidemic, , http://www.chinadaily.com.cn/a/202001/25/WS5e2bda00a310128217273360_2.html, Retrieved from; Dirks, D., Rice, S., Dining while black (2004) Cornell Hotel and Restaurant Administration Quarterly, 45 (1), pp. 30-47; Gill, A., Fitzgerald, S., Bhutani, S., Mand, H., Sharma, S., The relationship between transformational leadership and employee desire for empowerment (2010) International Journal of Contemporary Hospitality Management, 22 (2), pp. 263-273; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Cheng, Z., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) The Lancet, , …; Hui, D., Azhar, E., Madani, T., Ntoumi, F., Kock, R., Dar, O., Zumla, A., The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health—The latest 2019 novel coronavirus outbreak in Wuhan, China (2020) International Journal of Infectious Diseases, 91, pp. 264-266; Martinez, S., Alvarez, M., Country versus destination image in a developing country (2010) Journal of Travel & Tourism Marketing, 27 (7), pp. 748-764; Mossberg, L., Kleppe, I., Country and destination image–Different or similar image concepts? (2005) The Service Industries Journal, 25 (4), pp. 493-503; Notice of the National Health Commission on the provisional naming of the new coronavirus pneumonia, , http://www.nhc.gov.cn/xcs/zhengcwj/202002/18c1bb43965a4492907957875de02ae7.shtml, Retrieved from; Nisco, A., Mainolfi, G., Marino, V., Napolitano, M., Tourism satisfaction effect on general country image, destination image, and post-visit intentions (2015) Journal of Vacation Marketing, 21 (4), pp. 305-317; (2020) OHRC urges respect for human rights during Coronavirus health event’, , http://www.ohrc.on.ca/en/news_centre/statement-ohrc-urges-respect-human-rights-during-coronavirus-health-event, Retrieved from; Pager, D., Shepherd, H., The sociology of discrimination: Racial discrimination in employment, housing, credit, and consumer markets (2008) Annual Review of Sociology, 34, pp. 181-209; Peffley, M., Hurwitz, J., Mondak, J., Racial attributions in the justice system and support for punitive crime policies (2017) American Politics Research, 45 (6), pp. 1032-1058; Rich, M., As coronavirus spreads, so does anti-Chinese sentiments (2020) The New York Times, , https://www.nytimes.com/2020/01/30/world/asia/coronavirus-chinese-racism.html, Retrieved from; Rodriguez-Seijas, C., Stohl, M., Hasin, D., Eaton, N., Transdiagnostic factors and mediation of the relationship between perceived racial discrimination and mental disorders (2015) JAMA Psychiatry, 72 (7), pp. 706-713; Schultz, F., Utz, S., Göritz, A., Is the medium the message? Perceptions of and reactions to crisis communication via twitter, blogs and traditional media (2011) Public Relations Review, 37, pp. 20-27; Sellers, R., Shelton, N., The role of racial identity in perceived racial discrimination (2003) Journal of Personality and Social Psychology, 84 (5), pp. 1079-1092; Triana, M., Jayasinghe, M., Pieper, J., Perceived workplace racial discrimination and its correlates: A meta-analysis (2015) Journal of Organizational Behavior, 36, pp. 491-513; Tribe, J., The indiscipline of tourism (1997) Annals of Tourism Research, 24 (3), pp. 638-657; Unnever, J., Cullen, F., Barnes, J., Racial discrimination and pathways to delinquency: Testing a theory of African American offending (2017) Race and Justice, 7 (4), pp. 350-373; Wintemute, R., Israel-Palestine through the lens of racial discrimination law: Is the South African apartheid analogy accurate, and what if the European convention applied? (2017) King’s Law Journal, 28 (1), pp. 89-129; (2020) Novel coronavirus (2019-nCoV): Situation report–8, , https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200128-sitrep-8-ncov-cleared.pdf, Retrieved from; (2020) China builds new hospital in 10 days to combat coronavirus, , http://www.xinhuanet.com/english/2020-02/02/c_138750288.htm, Retrieved from","Wen, J.; School of Business and Law, Edith Cowan UniversityAustralia; email: j.wen@ecu.edu.au",,Routledge,13032917,,,,English,Anatolia,Note,Article in Press,,Scopus,2-s2.0-85079719906,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Dhama K., Sharun K., Tiwari R., Dadar M., Malik Y.S., Singh K.P., Chaicumpa W.",6507396956;56297714300;55314856100;55854080700;55407524100;35387019900;7006311280;,"COVID-19, an emerging coronavirus infection: advances and prospects in designing and developing vaccines, immunotherapeutics, and therapeutics",2020,Human Vaccines and Immunotherapeutics,,,,,,,,10.1080/21645515.2020.1735227,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082179834&doi=10.1080%2f21645515.2020.1735227&partnerID=40&md5=2b67d758a5d6b27635eb9782a97e9d7f,"Division of Pathology, ICAR-Indian Veterinary Research Institute, Bareilly, India; Division of Surgery, ICAR-Indian Veterinary Research Institute, Bareilly, India; Department of Veterinary Microbiology and Immunology, College of Veterinary Sciences, Deen Dayal Upadhayay Pashu Chikitsa Vigyan Vishwavidyalay Evum Go-Anusandhan Sansthan (DUVASU), Mathura, India; Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran; Division of Biological Standardization, ICAR-Indian Veterinary Research Institute, Bareilly, India; Center of Research Excellence on Therapeutic Proteins and Antibody Engineering, Department of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand","Dhama, K., Division of Pathology, ICAR-Indian Veterinary Research Institute, Bareilly, India; Sharun, K., Division of Surgery, ICAR-Indian Veterinary Research Institute, Bareilly, India; Tiwari, R., Department of Veterinary Microbiology and Immunology, College of Veterinary Sciences, Deen Dayal Upadhayay Pashu Chikitsa Vigyan Vishwavidyalay Evum Go-Anusandhan Sansthan (DUVASU), Mathura, India; Dadar, M., Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran; Malik, Y.S., Division of Biological Standardization, ICAR-Indian Veterinary Research Institute, Bareilly, India; Singh, K.P., Division of Pathology, ICAR-Indian Veterinary Research Institute, Bareilly, India; Chaicumpa, W., Center of Research Excellence on Therapeutic Proteins and Antibody Engineering, Department of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand","The novel coronavirus infection (COVID-19 or Coronavirus disease 2019) that emerged from Wuhan, Hubei province of China has spread to many countries worldwide. Efforts have been made to develop vaccines against human coronavirus (CoV) infections such as MERS and SARS in the past decades. However, to date, no licensed antiviral treatment or vaccine exists for MERS and SARS. Most of the efforts for developing CoV vaccines and drugs target the spike glycoprotein or S protein, the major inducer of neutralizing antibodies. Although a few candidates have shown efficacy in in vitro studies, not many have progressed to randomized animal or human trials, hence may have limited use to counter COVID-19 infection. 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Lu, L., Liu, Q., Du, L., Jiang, S., Middle East respiratory syndrome coronavirus (MERS-CoV): challenges in identifying its source and controlling its spread (2013) Microbes Infect, 15 (8-9), pp. 625-629; Li, G., De Clercq, E., Therapeutic options for the 2019 novel coronavirus (2019-nCoV) (2020) Nat Rev Drug Discov, 1-8; Sun, M.L., Yang, J.M., Sun, Y.P., Su, G.H., Inhibitors of RAS might be a good choice for the therapy of COVID-19 pneumonia (2020) ZhonghuaJie He Hu Xi ZaZhi, 43, p. E014. , Chinese; Zumla, A., Chan, J.F., Azhar, E.I., Hui, D.S., Yuen, K.Y., Coronaviruses - drug discovery and therapeutic options (2016) Nat Rev Drug Discov, 15 (5), pp. 327-347; Chan, J.F., Yao, Y., Yeung, M.L., Deng, W., Bao, L., Jia, L., Li, F., Yu, P., Treatment with lopinavir/ritonavir or interferon-β1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset (2015) J Infect Dis, 212 (12), pp. 1904-1913; Arabi, Y.M., Alothman, A., Balkhy, H.H., Al-Dawood, A., AlJohani, S., Al Harbi, S., Kojan, S., Assiri, A.M., Treatment of Middle East respiratory syndrome with a combination of lopinavir-ritonavir and interferon-β1b (MIRACLE trial): study protocol for a randomized controlled trial (2018) Trials, 19 (1), p. 81; Wang, C., Horby, P.W., Hayden, F.G., Gao, G.F., A novel coronavirus outbreak of global health concern (2020) Lancet, 395, pp. 470-473. , S0140-6736(20)30185-9; Cheng, V.C.C., Wong, S.C., To, K.K.W., Ho, P.L., Yuen, K.Y., Preparedness and proactive infection control measures against the emerging Wuhan coronavirus pneumonia in China (2020) J Hosp Infect","Dhama, K.; Division of Pathology, ICAR –Indian Veterinary Research InstituteIndia; email: kdhama@rediffmail.com",,Taylor and Francis Inc.,21645515,,,32186952,English,Hum. Vaccines Immunother.,Review,Article in Press,Open Access,Scopus,2-s2.0-85082179834,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Conway M.J.,57212792983;,"Identification of coronavirus sequences in carp cDNA from Wuhan, China",2020,Journal of Medical Virology,,,,,,,,10.1002/jmv.25751,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081731599&doi=10.1002%2fjmv.25751&partnerID=40&md5=37f3fabe539857b0207a7eed30ba6f51,"Foundational Sciences, Central Michigan University College of Medicine, Mount Pleasant, MI, United States","Conway, M.J., Foundational Sciences, Central Michigan University College of Medicine, Mount Pleasant, MI, United States","Severe acute respiratory syndrome (SARS)-like coronavirus sequences were identified in two separate complementary DNA (cDNA) pools. The first pool was from a Carassius auratus (crusian carp) cell line and the second was from Ctenopharyngodon idella (grass carp) head kidney tissue. BLAST analysis suggests that these sequences belong to SARS-like coronaviruses, and that they are not evolutionarily conserved in other species. Investigation of the submitting laboratories revealed that two laboratories from the Institute of Hydrobiology at the Chinese Academy of Sciences in Wuhan, China performed the research and submitted the cDNA libraries to GenBank. This institution is very close in proximity to the Wuhan South China Seafood Wholesale Market where SARS-CoV-2 first amplified in the human population. It is possible that these sequences are an artifact of the bioinformatics pipeline that was used. It is also possible that SARS-like coronaviruses are a common environmental pathogen in the region that may be in aquatic habitats. © 2020 Wiley Periodicals, Inc.",epidemiology; SARS coronavirus; virus classification; water-borne epidemics,,"Corman, V.M., Muth, D., Niemeyer, D., Drosten, C., Hosts and sources of endemic human coronaviruses (2018) Adv Virus Res, 100, pp. 163-188; Li, X., Zai, J., Zhao, Q., Evolutionary history, potential intermediate animal host, and cross-species analyses of SARS-CoV-2 (2020) J Med Virol, pp. 1-10. , https://doi.org/10.1002/jmv.25731, [published online ahead of print February 27, 2020]; Liu, Z., Xiao, X., Wei, X., Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS-CoV-2 (2020) J Med Virol, pp. 1-7. , https://doi.org/10.1002/jmv.25726, [published online ahead of print February 26, 2020]; Lai, M.M., SARS virus: the beginning of the unraveling of a new coronavirus (2003) J Biomed Sci, 10, pp. 664-675; Coleman, C.M., Frieman, M.B., Emergence of the Middle East respiratory syndrome coronavirus (2013) PLoS Pathog, 9; Zhong, X.P., Wang, D., Zhang, Y.B., Gui, J.F., Identification and characterization of hypoxia-induced genes in Carassius auratus blastulae embryonic cells using suppression subtractive hybridization (2009) Comp Biochem Physiol B Biochem Mol Biol, 152, pp. 161-170; Adams, M.D., Kelley, J.M., Gocayne, J.D., Complementary DNA sequencing: expressed sequence tags and human genome project (1991) Science, 252, pp. 1651-1656","Conway, M.J.; Foundational Sciences, Central Michigan University College of MedicineUnited States; email: michael.conway@cmich.edu",,John Wiley and Sons Inc.,1466615,,JMVID,32159234,English,J. Med. Virol.,Article,Article in Press,Open Access,Scopus,2-s2.0-85081731599,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Jiang S., Shi Z.-L.",56491898300;7403733955;,The First Disease X is Caused by a Highly Transmissible Acute Respiratory Syndrome Coronavirus,2020,Virologica Sinica,,,,,,,1,10.1007/s12250-020-00206-5,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079722627&doi=10.1007%2fs12250-020-00206-5&partnerID=40&md5=74dce354264dc9e9cfdda8fd5276f33b,"Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China; New York Blood Center, The Lindsley F. Kimball Research Institute, New York, NY 10065, United States; CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China","Jiang, S., Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China, New York Blood Center, The Lindsley F. Kimball Research Institute, New York, NY 10065, United States; Shi, Z.-L., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China","Based on the announcement of the World Health Organization (WHO) in 2018, the Wuhan pneumonia caused by an unknown etiology should be recognized as the first Disease X. Later, the pathogen was identified to be a novel coronavirus denoted 2019-nCoV, which has 79.5% and 96% whole genome sequence identify to SARS-CoV and bat SARS-related coronavirus (SARSr-CoV-RaTG13), respectively, suggesting its potential bat origin. With high human-to-human transmission rate (R0), 2019-nCoV has quickly spread in China and other countries, resulting in 34,953 confirmed cases and 725 deaths as of 8 February 2020, thus calling for urgent development of therapeutics and prophylactics. Here we suggest renaming 2019-nCoV as “transmissible acute respiratory syndrome coronavirus (TARS-CoV)” and briefly review the advancement of research and development of neutralizing antibodies and vaccines targeting the receptor-binding domain (RBD) and viral fusion inhibitors targeting the heptad repeat 1 (HR1) domain in spike protein of 2019-nCoV. © 2020, Wuhan Institute of Virology, CAS.",2019-nCoV; Acute respiratory syndrome; Coronavirus; Disease X; Pneumonia; SARS-CoV,,"Chen, J., Pathogenicity and transmissibility of 2019-nCoV—a quick overview and comparison with other emerging viruses (2020) Microbes Infect; Cui, J., Li, F., Shi, Z.L., Origin and evolution of pathogenic coronaviruses (2019) Nat Rev Microbiol, 17, pp. 181-192. , COI: 1:CAS:528:DC%2BC1cXisVyhtbnL; de Groot, R.J., Baker, S.C., Baric, R.S., Brown, C.S., Drosten, C., Enjuanes, L., Fouchier, R.A., Ziebuhr, J., Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group (2013) J Viro, 87, pp. 7790-7792; Du, L., He, Y., Zhou, Y., Liu, S., Zheng, B.J., Jiang, S., The spike protein of SARS-CoV–a target for vaccine and therapeutic development (2009) Nat Rev Microbiol, 7, pp. 226-236. , COI: 1:CAS:528:DC%2BD1MXhsFeqs7Y%3D; Du, L., Tai, W., Yang, Y., Zhao, G., Zhu, Q., Sun, S., Liu, C., Li, F., Introduction of neutralizing immunogenicity index to the rational design of MERS coronavirus subunit vaccines (2016) Nat Commun, 7, p. 13473. , COI: 1:CAS:528:DC%2BC28XitFSnsrbF; Ge, X.Y., Li, J.L., Yang, X.L., Chmura, A.A., Zhu, G., Epstein, J.H., Mazet, J.K., Shi, Z.L., Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor (2013) Nature, 503, pp. 535-538. , COI: 1:CAS:528:DC%2BC3sXhslSnsLrF; Jiang, S., Lin, K., Strick, N., Neurath, A.R., HIV-1 inhibition by a peptide (1993) Nature, 365, p. 113. , COI: 1:CAS:528:DyaK3sXmtFKrsrc%3D; Jiang, S., Du, L., Shi, Z., An emerging coronavirus causing pneumonia outbreak in Wuhan, China: calling for developing therapeutic and prophylactic strategies (2020) Emerg Microbes Infect, 9, pp. 275-277; Jiang, S., Xia, S., Ying, T., Lu, L., Novel coronavirus 2019-nCoV causing pneumonia- associated respiratory syndrome (2020) Cell Mol Immunol; Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Ren, R., Feng, Z., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med; Liu, S., Xiao, G., Chen, Y., He, Y., Niu, J., Escalante, C.R., Xiong, H., Jiang, S., Interaction between the heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: implication for virus fusogenic mechanism and identification of fusion inhibitors (2004) Lancet, 363, pp. 938-947. , COI: 1:CAS:528:DC%2BD2cXisVSktbo%3D; Lu, L., Liu, Q., Zhu, Y., Chan, K.H., Qin, L., Li, Y., Wang, Q., Jiang, S., Structure-based discovery of Middle East respiratory syndrome coronavirus (MERS-CoV) fusion inhibitor (2014) Nat Commun, 5, p. 3067; Tian, X., Li, C., Huang, A., Xia, S., Lu, S., Shi, Z., Lu, L., Ying, T., Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody (2020) Emerg Microbes Infect; Xia, S., Yan, L., Xu, W., Agrawal, A.S., Algaissi, A., Tseng, C.K., Wang, Q., Lu, L., A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike (2019) Sci Adv, 5, p. eaav4580. , COI: 1:CAS:528:DC%2BC1MXhvFWgt77I; Xia, S., Zhu, Y., Liu, M., Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein (2020) Cell Mol Immunol; Zeng, L.P., Ge, X.Y., Peng, C., Tai, W., Jiang, S., Du, L., Shi, Z.L., Cross-neutralization of SARS coronavirus-specific antibodies against bat SARS-like coronaviruses (2017) Sci China Life Sci, 60, pp. 1399-1402. , COI: 1:CAS:528:DC%2BC2sXhvVSmsrjM; Zhao, S., Musa, S.S., Lin, Q., Ran, J., Yang, G., Wang, W., Lou, Y., Wang, M.H., Estimating the unreported number of novel coronavirus (2019-nCoV) Cases in China in the First Half of January 2020: a data-driven modelling analysis of the early outbreak (2020) J Clin Med, 9 (2), p. E388; Zhou, P., Yang, X.L., Wang, X.G., Hu, B., Zhang, L., Zhang, W., Si, H.R., Shi, Z.L., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature","Jiang, S.; New York Blood Center, The Lindsley F. Kimball Research InstituteUnited States; email: shibojiang@fudan.edu.cn",,Science Press,16740769,,,32060789,English,Virol. Sin.,Review,Article in Press,Open Access,Scopus,2-s2.0-85079722627,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Jiang F., Deng L., Zhang L., Cai Y., Cheung C.W., Xia Z.",57215651484;7202007437;54977399000;56497363200;57215184700;7402151748;,Review of the Clinical Characteristics of Coronavirus Disease 2019 (COVID-19),2020,Journal of General Internal Medicine,,,,,,,1,10.1007/s11606-020-05762-w,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081542040&doi=10.1007%2fs11606-020-05762-w&partnerID=40&md5=f75ab3c33c49fef3039a61eda001735f,"Department of Anesthesiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong; Department of Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China; Department of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China","Jiang, F., Department of Anesthesiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong; Deng, L., Department of Critical Care Medicine, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China; Zhang, L., Department of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China; Cai, Y., Department of Anesthesiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong; Cheung, C.W., Department of Anesthesiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong; Xia, Z., Department of Anesthesiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Department of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China","In late December 2019, a cluster of cases with 2019 Novel Coronavirus pneumonia (SARS-CoV-2) in Wuhan, China, aroused worldwide concern. Previous studies have reported epidemiological and clinical characteristics of coronavirus disease 2019 (COVID-19). The purpose of this brief review is to summarize those published studies as of late February 2020 on the clinical features, symptoms, complications, and treatments of COVID-19 and help provide guidance for frontline medical staff in the clinical management of this outbreak. © 2020, Society of General Internal Medicine.",coronavirus; COVID-19; pneumonia; review; SARS-CoV-2; Wuhan,,"Wang, C., Horby, P.W., Hayden, F.G., Gao, G.F., A novel coronavirus outbreak of global health concern (2020) The Lancet, 395 (10223), pp. 470-473; Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., Zhao, X., Tan, W., A Novel Coronavirus from Patients with Pneumonia in China, 2019 (2020) New England Journal of Medicine, 382 (8), pp. 727-733; Coronavirus Disease 2019 (COVID-19) Situation Report-36, , https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports/.Updated2020, Accessed February 25, 2020; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Cao, B., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) The Lancet, 395 (10223), pp. 497-506; Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Zhang, L., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) The Lancet, 395 (10223), pp. 507-513; Li, Q., Guan, X., Wu, P., Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia (2020) N Engl J Med, , https://doi.org/10.1056/NEJMoa2001316, Epub ahead of print; Song, F., Shi, N., Shan, F., Emerging Coronavirus 2019-nCoV Pneumonia (2020) Radiology., 6, p. 200274. , [Epub ahead of print]; Chen, L., Liu, H.G., Liu, W., Analysis of clinical features of 29 patients with 2019 novel coronavirus pneumonia (2020) Zhonghua Jie He He Hu Xi Za Zhi, 43, p. E005. , [Epub ahead of print]; Wang, D., Hu, B., Hu, C., Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China (2020) JAMA, , https://doi.org/10.1001/jama.2020.1585, [Epub ahead of print]; de Wit, E., van Doremalen, N., Falzarano, D., Munster, V.J., SARS and MERS: recent insights into emerging coronaviruses (2016) Nat Rev Microbiol., 14 (8), pp. 523-534; Zhou, P., Yang, X.L., Wang, X.G., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature, , https://doi.org/10.1038/s41586-020-2012-7, Epub ahead of print; Wan, Y., Shang, J., Graham, R., Baric, R.S., Li, F., Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS (2020) J Virol, , https://doi.org/10.1128/JVI.00127-20, JVI.00127-20, [Epub ahead of print]; Holshue, M.L., Debolt, C., Lindquist, S., First case of 2019 novel coronavirus in the United States (2020) N Engl J Med, , https://doi.org/10.1056/NEJMoa2001191, published online; (2020), http://www.xinhuanet.com/english/2020-02/13/c_138780710.htm, Xinhuanet, Feb 13, 2020; Phan, L.T., Nguyen, T.V., Luong, Q.C., Nguyen, T.V., Nguyen, H.T., Le, H.Q., Nguyen, T.T., Pham, Q.D., Importation and Human-to-Human Transmission of a Novel Coronavirus in Vietnam (2020) New England Journal of Medicine, 382 (9), pp. 872-874; Chan, J.F., Yuan, S., Kok, K.H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: A study of a family cluster Lancet, 2020. , published online Jan 24; Chen, H., Guo, J., Wan, C., Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: A retrospective review of medical records, , https://doi.org/10.1016/S0140-6736(20)30360-3; Rothe, C., Schunk, M., Sothmann, P., Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany (2020) N Engl J Med, , https://doi.org/10.1056/NEJMc2001468, Epub ahead of print; Hoehl, S., Rabenau, H., Berger, A., Evidence of SARS-CoV-2 Infection in Returning Travelers from Wuhan, China (2020) New England Journal of Medicine, , https://doi.org/10.1056/NEJMc2001899, Epub ahead of print; Lu, C.-W., Liu, X.-F., Jia, Z.-F., 2019-nCoV transmission through the ocular surface must not be ignored (2020) The Lancet, 395 (10224); http://www.xinhuanet.com/english/2020-02/12/c_138777886.htm, Huaxia. WHO says vaccines against novel coronavirus 18 months away, pushes global research. 2020. Xinhuanet, Feb 12, 2020; (2020) A Randomized, Open-Label, Blank-Controlled Trial for the Efficacy and Safety of Lopinavir-Ritonavir and Interferon-Alpha 2B in Hospitalization Patients with Novel Coronavirus Infection, , www.chictr.org.cn/showprojen.aspx?proj=48684, Available from, Accessed February 24; Kui, L., Fang, Y.Y., Deng, Y., Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province Chin Med J (Engl), 2020. , https://doi.org/10.1097/CM9.0000000000000744, Epub ahead of print; Richardson, P., Griffin, I., Tucker, C., Smith, D., Oechsle, O., Phelan, A., Stebbing, J., Baricitinib as potential treatment for 2019-nCoV acute respiratory disease (2020) The Lancet, 395 (10223), pp. e30-e31","Xia, Z.; Department of Anesthesiology, Li Ka Shing Faculty of Medicine, The University of Hong KongHong Kong; email: zyxia@hku.hk",,Springer,8848734,,JGIME,32133578,English,J. Gen. Intern. Med.,Review,Article in Press,Open Access,Scopus,2-s2.0-85081542040,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Li M., Lei P., Zeng B., Li Z., Yu P., Fan B., Wang C., Li Z., Zhou J., Hu S., Liu H.",57215831101;57193258125;57215835058;57215831699;57215831020;57215081757;57215836653;57215831720;57191735951;57215834821;57215836590;,Coronavirus Disease (COVID-19): Spectrum of CT Findings and Temporal Progression of the Disease,2020,Academic Radiology,,,,,,,,10.1016/j.acra.2020.03.003,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081995497&doi=10.1016%2fj.acra.2020.03.003&partnerID=40&md5=cad06b30296bf3ee82ff6d2428c37758,"Radiology Department, Jiangxi Provincial People's Hospital, Nanchang, 330006, China; Department of Radiology, The Affifiliated Hospital of Guizhou Medical University, Guiyang, China; Department of Radiology, Nanfeng County People's Hospital, Fuzhou, China; Radiology Department, Jinxian County People's Hospital, Nanchang, China; Medical AI, China","Li, M., Radiology Department, Jiangxi Provincial People's Hospital, Nanchang, 330006, China; Lei, P., Department of Radiology, The Affifiliated Hospital of Guizhou Medical University, Guiyang, China; Zeng, B., Radiology Department, Jiangxi Provincial People's Hospital, Nanchang, 330006, China; Li, Z., Department of Radiology, Nanfeng County People's Hospital, Fuzhou, China; Yu, P., Radiology Department, Jinxian County People's Hospital, Nanchang, China; Fan, B., Radiology Department, Jiangxi Provincial People's Hospital, Nanchang, 330006, China; Wang, C., Radiology Department, Jiangxi Provincial People's Hospital, Nanchang, 330006, China; Li, Z., Radiology Department, Jiangxi Provincial People's Hospital, Nanchang, 330006, China; Zhou, J., Radiology Department, Jiangxi Provincial People's Hospital, Nanchang, 330006, China; Hu, S., Radiology Department, Jiangxi Provincial People's Hospital, Nanchang, 330006, China; Liu, H., Medical AI, China","Coronavirus disease is an emerging infection caused by a novel coronavirus that is moving rapidly. High resolution computed tomography (CT) allows objective evaluation of the lung lesions, thus enabling us to better understand the pathogenesis of the disease. With serial CT examinations, the occurrence, development, and prognosis of the disease can be better understood. The imaging can be sorted into four phases: early phase, progressive phase, severe phase, and dissipative phase. The CT appearance of each phase and temporal progression of the imaging findings are demonstrated. © 2020 The Association of University Radiologists",2019-nCoV; Coronavirus; COVID-19; Pneumonia; Tomography; X-ray computed,,"Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395 (10223), pp. 507-513; Wu, F., Zhao, S., Yu, B., A new coronavirus associated with human respiratory disease in China (2020) Nature; Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382 (8), pp. 727-733; Wrapp, D., Wang, N., Corbett, K.S., Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation (2020) Science; Zhang, H.W., Yu, J., Xu, H.J., Corona virus international public health emergencies: implications for radiology management (2020) Acad Radiol; Pan, F., Ye, T., Sun, P., Time course of lung changes on chest CT during recovery from 2019 novel coronavirus (COVID-19) pneumonia (2020) Radiology; Fang, Y., Zhang, H., Xie, J., Sensitivity of chest CT for COVID-19: comparison to RT-PCR (2020) Radiology; Liu, P., Tan, X.Z., 2019 novel coronavirus (2019-nCoV) pneumonia (2020) Radiology; Zu, Z.Y., Jiang, M.D., Xu, P.P., Coronavirus disease 2019 (COVID-19): a perspective from China (2020) Radiology; Pan, Y., Guan, H., Zhou, S., Initial CT findings and temporal changes in patients with the novel coronavirus pneumonia (2019-nCoV): a study of 63 patients in Wuhan, China (2020) Eur Radiol; Kim, J.Y., Ko, J.H., Kim, Y., Viral load kinetics of SARS-CoV-2 infection in first two patients in Korea (2020) J Korean Med Sci, 35 (7), p. e86; Lin, X., Gong, Z., Xiao, Z., Novel coronavirus pneumonia outbreak in 2019: computed tomographic findings in two cases (2020) Korean J Radiol; Bernheim, A., Mei, X., Huang, M., Chest CT findings in coronavirus disease-19 (COVID-19): relationship to duration of infection (2020) Radiology; Kanne, J.P., Chest CT findings in 2019 novel coronavirus (2019-nCoV) infections from Wuhan, China: key points for the radiologist (2020) Radiology; Lei, J., Li, J., Li, X., CT Imaging of the 2019 novel coronavirus (2019-nCoV) pneumonia (2020) Radiology, 295 (1); Chung, M., Bernheim, A., Mei, X., CT imaging features of 2019 novel coronavirus (2019-nCoV) (2020) Radiology; Chan, M.S., Chan, I.Y., Fung, K.H., Poon, E., Yam, L.Y., Lau, K.Y., High-resolution CT findings in patients with severe acute respiratory syndrome: a pattern-based approach (2004) AJR Am J Roentgenol, 182, pp. 49-56; Rao, T.N., Paul, N., Chung, T., Value of CT in assessing probable severe acute respiratory syndrome (2003) AJR Am J Roentgenol, 181 (2), pp. 317-319; Long, J.B., Ehrenfeld, J.M., The role of augmented intelligence (AI) in detecting and preventing the spread of novel coronavirus (2020) J Med Syst, 44 (3), p. 59","Fan, B.; Radiology Department, Jiangxi Provincial People's HospitalChina; email: 26171381@qq.com",,Elsevier USA,10766332,,ARADF,,English,Acad. Radiol.,Review,Article in Press,Open Access,Scopus,2-s2.0-85081995497,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Shen M., Zhou Y., Ye J., Abdullah AL-maskri A.A., Kang Y., Zeng S., Cai S.",57215577484;57213434670;57204725480;57204732111;35388576800;7202412537;56406588100;,Recent advances and perspectives of nucleic acid detection for coronavirus,2020,Journal of Pharmaceutical Analysis,,,,,,,,10.1016/j.jpha.2020.02.010,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081236303&doi=10.1016%2fj.jpha.2020.02.010&partnerID=40&md5=06147a50c20f39d309a1444f47f958f3,"Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China","Shen, M., Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China; Zhou, Y., Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China; Ye, J., Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China; Abdullah AL-maskri, A.A., Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China; Kang, Y., Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China; Zeng, S., Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China; Cai, S., Institute of Drug Metabolism and Pharmaceutical Analysis, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, China","The recent pneumonia outbreak caused by a novel coronavirus (SARS-CoV-2) in Chinais posing a great threat to global public health. Therefore, rapid and a accurate identification of pathogenic viruses plays a vital role in selecting appropriate treatments, saving people's lives and preventing epidemics. It is important to establish a quick standard diagnostic test for the detection of the infectious disease (COVID-19) to prevent subsequent secondary spread. Polymerase chain reaction (PCR) is regarded as a gold standard test for the molecular diagnosis of viral and bacterial infections with high sensitivity and specificity. Isothermal nucleic acid amplification is considered to be a highly promising candidate method due to its fundamental advantage in quick procedure time at constant temperature without thermocycler operation. A variety of improved or new approaches also have been developed. This review summarizes the currently available detection methods for coronavirus nucleic acid. It is anticipated that this will assist researchers and clinicians in developing better techniques for timely and effective detection of coronavirus infection. © 2020 Xi'an Jiaotong University",Coronavirus; Isothermal nucleic acid amplification-based methods; Microarray-based methods; Nucleic acid detection; PCR-Based methods,,"Morens, D.M., Fauci, A.S., Emerging infectious diseases: threats to human health and global stability (2013) PLoS Pathog., 9; Kim, H., Park, M., Hwang, J., Development of label-free colorimetric assay for MERS-CoV using gold nanoparticles (2019) ACS Sens., 4, pp. 1306-1312; Zhang, N., Wang, L., Deng, X., Recent advances in the detection of respiratory virus infection in humans (2020) J. Med. Virol., 92, pp. 408-417; Huang, P., Wang, H., Cao, Z., A rapid and specific assay for the detection of MERS-CoV (2018) Front. 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E63; Enosawa, M., Kageyama, S., Sawai, K., Use of loop-mediated isothermal amplification of the IS900 sequence for rapid detection of cultured Mycobacterium avium subsp. paratuberculosis (2003) J. Clin. Microbiol., 41, pp. 4359-4365; Poon, L.L.M., Leung, C.S.W., Tashiro, M., Rapid detection of the severe acute respiratory syndrome (SARS) coronavirus by a loop-mediated isothermal amplification assay (2004) Clin. Chem., 50, pp. 1050-1052; Pyrc, K., Milewska, A., Potempa, J., Development of loop-mediated isothermal amplification assay for detection of human coronavirus-NL63 (2011) J. Virol. Methods, 175, pp. 133-136; Mori, Y., Nagamine, K., Tomita, N., Detection of loop-mediated isothermal amplification reaction by turbidity derived from magnesium pyrophosphate formation (2001) Biochem. Biophys. Res. Commun., 289, pp. 150-154; Shirato, K., Yano, T., Senba, S., Detection of Middle East respiratory syndrome coronavirus using reverse transcription loop-mediated isothermal amplification (RT-LAMP) (2014) Virol. J., 11, p. 139; Thai, H.T.C., Le, M.Q., Vuong, C.D., Development and evaluation of a novel loop-mediated isothermal amplification method for rapid detection of severe acute respiratory syndrome coronavirus (2004) J. Clin. Microbiol., 42, pp. 1956-1961; Njiru, Z.K., Loop-mediated isothermal amplification technology: towards point of care diagnostics (2012) Plos Neglect. Trop. Dis., 6; Shirato, K., Semba, S., El-Kafrawy, S.A., Development of fluorescent reverse transcription loop-mediated isothermal amplification (RT-LAMP) using quenching probes for the detection of the Middle East respiratory syndrome coronavirus (2018) J. Virol. 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Pharmaceut.Analy.,Review,Article in Press,Open Access,Scopus,2-s2.0-85081236303,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Xu J., Zhao S., Teng T., Abdalla A.E., Zhu W., Xie L., Wang Y., Guo X.",57215198146;57215196773;54795957200;56497596800;57195614212;55391350800;55922463800;37058951700;,Systematic comparison of two animal-to-human transmitted human coronaviruses: SARS-CoV-2 and SARS-CoV,2020,Viruses,12,2,244,,,,3,10.3390/v12020244,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080049910&doi=10.3390%2fv12020244&partnerID=40&md5=2c84aeb5c3aa0d8a64b21385f5fc6ebb,"Department of Preventive Medicine, Institute of Biomedical Informatics, Bioinformatics Center, Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Basic Medical Sciences, Henan University, Kaifeng, 475004, China; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka, 2014, Saudi Arabia; Department of Anesthesia, Stanford University, Stanford, CA 94305, United States; Henan Bioengineering Research Center, Zhengzhou, 450046, China","Xu, J., Department of Preventive Medicine, Institute of Biomedical Informatics, Bioinformatics Center, Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Basic Medical Sciences, Henan University, Kaifeng, 475004, China; Zhao, S., Department of Preventive Medicine, Institute of Biomedical Informatics, Bioinformatics Center, Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Basic Medical Sciences, Henan University, Kaifeng, 475004, China; Teng, T., Department of Preventive Medicine, Institute of Biomedical Informatics, Bioinformatics Center, Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Basic Medical Sciences, Henan University, Kaifeng, 475004, China; Abdalla, A.E., Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka, 2014, Saudi Arabia; Zhu, W., Department of Anesthesia, Stanford University, Stanford, CA 94305, United States; Xie, L., Department of Preventive Medicine, Institute of Biomedical Informatics, Bioinformatics Center, Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Basic Medical Sciences, Henan University, Kaifeng, 475004, China; Wang, Y., Henan Bioengineering Research Center, Zhengzhou, 450046, China; Guo, X., Department of Preventive Medicine, Institute of Biomedical Informatics, Bioinformatics Center, Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Basic Medical Sciences, Henan University, Kaifeng, 475004, China","After the outbreak of the severe acute respiratory syndrome (SARS) in the world in 2003, human coronaviruses (HCoVs) have been reported as pathogens that cause severe symptoms in respiratory tract infections. Recently, a new emerged HCoV isolated from the respiratory epithelium of unexplained pneumonia patients in theWuhan seafood market caused a major disease outbreak and has been named the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This virus causes acute lung symptoms, leading to a condition that has been named as ""coronavirus disease 2019"" (COVID-19). The emergence of SARS-CoV-2 and of SARS-CoV caused widespread fear and concern and has threatened global health security. There are some similarities and differences in the epidemiology and clinical features between these two viruses and diseases that are caused by these viruses. The goal of this work is to systematically review and compare between SARS-CoV and SARS-CoV-2 in the context of their virus incubation, originations, diagnosis and treatment methods, genomic and proteomic sequences, and pathogenic mechanisms. © 2020 by the authors.",Clinical manifestations; Coronaviruses; Genomic comparison; Pathogenic mechanism; Proteomic comparison; SARS-CoV; SARS-CoV-2,"adult respiratory distress syndrome; amino acid sequence; Article; artificial ventilation; breathing rate; China; computer assisted tomography; Coronavirinae; coughing; dyspnea; epidemic; fatigue; gene sequence; hospital personnel; hospitalization; human; Human immunodeficiency virus infection; intensive care unit; Middle East respiratory syndrome; mortality rate; myalgia; nonhuman; novel coronavirus 2019; novel coronavirus disease 2019; phylogeny; pneumonia; prevalence; respiratory distress; respiratory epithelium; reverse transcription polymerase chain reaction; SARS coronavirus; sequence alignment; sequence homology; upregulation; virus isolation; virus pneumonia; virus replication; virus transmission; zoonosis; animal; bat; Betacoronavirus; chemistry; comparative study; Coronavirus infection; disease carrier; disease predisposition; genetics; global health; incubation time; pathogenicity; placental mammal; severe acute respiratory syndrome; virology; virus genome; virus pneumonia; COVID-19; proteome; severe acute respiratory syndrome coronavirus 2; viral protein; Animals; Betacoronavirus; China; Chiroptera; Coronavirus Infections; Disease Reservoirs; Disease Susceptibility; Eutheria; Genome, Viral; Global Health; Humans; Infectious Disease Incubation Period; Pneumonia, Viral; Proteome; SARS Virus; Sequence Alignment; Severe Acute Respiratory Syndrome; Viral Proteins","Wang, L.F., Shi, Z., Zhang, S., Field, H., Daszak, P., Eaton, B.T., Review of bats and SARS (2006) Emerg. 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Dis., 20, p. 1049","Guo, X.; Department of Preventive Medicine, Institute of Biomedical Informatics, Bioinformatics Center, Henan Provincial Engineering Center for Tumor Molecular Medicine, School of Basic Medical Sciences, Henan UniversityChina; email: xqguo@henu.edu.cn",,MDPI AG,19994915,,,32098422,English,Viruses,Article,Final,Open Access,Scopus,2-s2.0-85080049910,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Sekimukai H., Iwata-Yoshikawa N., Fukushi S., Tani H., Kataoka M., Suzuki T., Hasegawa H., Niikura K., Arai K., Nagata N.",57207566611;37031266800;7004841901;7101687362;7201555212;57208634633;55485164600;7006034127;57214212040;11839905700;,"Gold nanoparticle-adjuvanted S protein induces a strong antigen-specific IgG response against severe acute respiratory syndrome-related coronavirus infection, but fails to induce protective antibodies and limit eosinophilic infiltration in lungs",2020,Microbiology and Immunology,64,1,,33,51,,,10.1111/1348-0421.12754,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85075138721&doi=10.1111%2f1348-0421.12754&partnerID=40&md5=cdd44c9a87491934b82ccc1a7fcafe82,"Department of Pathology, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan; Department of Tissue Physiology, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan; Department of Virology I, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan; Research Institute for Electronic Science, Hokkaido University, Sapporo, Hokkaido, Japan","Sekimukai, H., Department of Pathology, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan, Department of Tissue Physiology, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan; Iwata-Yoshikawa, N., Department of Pathology, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan; Fukushi, S., Department of Virology I, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan; Tani, H., Department of Virology I, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan; Kataoka, M., Department of Pathology, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan; Suzuki, T., Department of Pathology, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan; Hasegawa, H., Department of Pathology, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan; Niikura, K., Research Institute for Electronic Science, Hokkaido University, Sapporo, Hokkaido, Japan; Arai, K., Department of Tissue Physiology, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan; Nagata, N., Department of Pathology, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan","The spike (S) protein of coronavirus, which binds to cellular receptors and mediates membrane fusion for cell entry, is a candidate vaccine target for blocking coronavirus infection. However, some animal studies have suggested that inadequate immunization against severe acute respiratory syndrome coronavirus (SARS-CoV) induces a lung eosinophilic immunopathology upon infection. The present study evaluated two kinds of vaccine adjuvants for use with recombinant S protein: gold nanoparticles (AuNPs), which are expected to function as both an antigen carrier and an adjuvant in immunization; and Toll-like receptor (TLR) agonists, which have previously been shown to be an effective adjuvant in an ultraviolet-inactivated SARS-CoV vaccine. All the mice immunized with more than 0.5 µg S protein without adjuvant escaped from SARS after infection with mouse-adapted SARS-CoV; however, eosinophilic infiltrations were observed in the lungs of almost all the immunized mice. The AuNP-adjuvanted protein induced a strong IgG response but failed to improve vaccine efficacy or to reduce eosinophilic infiltration because of highly allergic inflammatory responses. Whereas similar virus titers were observed in the control animals and the animals immunized with S protein with or without AuNPs, Type 1 interferon and pro-inflammatory responses were moderate in the mice treated with S protein with and without AuNPs. On the other hand, the TLR agonist-adjuvanted vaccine induced highly protective antibodies without eosinophilic infiltrations, as well as Th1/17 cytokine responses. The findings of this study will support the development of vaccines against severe pneumonia-associated coronaviruses. © 2019 The Societies and John Wiley & Sons Australia, Ltd",adjuvant; coronavirus; eosinophils; gold nanoparticles; immunopathology; mouse model,"gold nanoparticle; immunoglobulin G; immunological adjuvant; inactivated virus vaccine; interferon; nanocarrier; recombinant protein; recombinant spike protein; severe acute respiratory syndrome vaccine; toll like receptor agonist; unclassified drug; virus spike protein; coronavirus spike glycoprotein; cytokine; gold; immunoglobulin G; immunological adjuvant; metal nanoparticle; recombinant protein; recombinant vaccine; S protein, severe acute respiratory syndrome coronavirus; toll like receptor; virus antibody; virus envelope protein; virus vaccine; animal cell; animal experiment; animal model; animal tissue; antibody production; antigen specificity; Article; controlled study; dose response; drug delivery system; drug efficacy; eosinophil; female; histopathology; immune response; leukocyte migration; lung infiltrate; mouse; nonhuman; SARS-related coronavirus; severe acute respiratory syndrome; Th1 cell; Th17 cell; treatment duration; ultraviolet radiation; vaccination; vaccine immunogenicity; virus inactivation; virus load; analysis of variance; animal; Bagg albino mouse; chemistry; Chlorocebus aethiops; Coronavirinae; Coronavirus infection; disease model; genetics; immunization; immunology; lung; metabolism; pathology; SARS coronavirus; severe acute respiratory syndrome; Vero cell line; virology; Adjuvants, Immunologic; Analysis of Variance; Animals; Antibodies, Viral; Chlorocebus aethiops; Coronavirus; Coronavirus Infections; Cytokines; Disease Models, Animal; Female; Gold; Immunization; Immunoglobulin G; Lung; Metal Nanoparticles; Mice; Mice, Inbred BALB C; Recombinant Proteins; SARS Virus; Severe Acute Respiratory Syndrome; Spike Glycoprotein, Coronavirus; Toll-Like Receptors; Vaccination; Vaccines, Synthetic; 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He, Y., Lu, H., Siddiqui, P., Zhou, Y., Jiang, S., Receptor-binding domain of severe acute respiratory syndrome coronavirus spike protein contains multiple conformation-dependent epitopes that induce highly potent neutralizing antibodies (2005) J Immunol, 174, pp. 4908-4915; See, R.H., Zakhartchouk, A.N., Petric, M., Comparative evaluation of two severe acute respiratory syndrome (SARS) vaccine candidates in mice challenged with SARS coronavirus (2006) J Gen Virol, 87, pp. 641-650; Woo, P.C., Lau, S.K., Tsoi, H.W., SARS coronavirus spike polypeptide DNA vaccine priming with recombinant spike polypeptide from Escherichia coli as booster induces high titer of neutralizing antibody against SARS coronavirus (2005) Vaccine, 23, pp. 4959-4968; Zhao, J., Li, K., Wohlford-Lenane, C., Rapid generation of a mouse model for Middle East respiratory syndrome (2014) Proc Natl Acad Sci U S A, 111, pp. 4970-4975; Song, Z., Xu, Y., Bao, L., From SARS to MERS, thrusting coronaviruses into the spotlight (2019) Viruses, 11, p. 59; Agrawal, A.S., Tao, X., Algaissi, A., Immunization with inactivated Middle East Respiratory Syndrome coronavirus vaccine leads to lung immunopathology on challenge with live virus (2016) Hum Vaccin Immunother, 12, pp. 2351-2356; Mukhopadhyay, A., Basu, S., Singha, S., Patra, H.K., Inner-view of nanomaterial incited protein conformational changes: insights into designable interaction Research. 2018;, 2018, pp. 1-15; Nguyen, V.H., Lee, B.J., Protein corona: a new approach for nanomedicine design (2017) Int J Nanomedicine, 12, pp. 3137-3151; Monopoli, M.P., Aberg, C., Salvati, A., Dawson, K.A., Biomolecular coronas provide the biological identity of nanosized materials (2012) Nat Nanotechnol, 7, pp. 779-786; Lacerda, S.H., Park, J.J., Meuse, C., Interaction of gold nanoparticles with common human blood proteins (2010) ACS Nano, 4, pp. 365-379; Russell, B.A., Jachimska, B., Komorek, P., Mulheran, P.A., Chen, Y., Lysozyme encapsulated gold nanoclusters: effects of cluster synthesis on natural protein characteristics (2017) Phys Chem Chem Phys, 19, pp. 7228-7235; Levy, D.E., Marie, I.J., Durbin, J.E., Induction and function of type I and III interferon in response to viral infection (2011) Curr Opin Virol, 1, pp. 476-486; Stetson, D.B., Medzhitov, R., Type I interferons in host defense (2006) Immunity, 25, pp. 373-381; Nagata, N., Iwata, N., Hasegawa, H., Participation of both host and virus factors in induction of severe acute respiratory syndrome (SARS) in F344 rats infected with SARS coronavirus (2007) J Virol, 81, pp. 1848-1857; Chen, J., Lau, Y.F., Lamirande, E.W., Cellular immune responses to severe acute respiratory syndrome coronavirus (SARS-CoV) infection in senescent BALB/c mice: CD4+ T cells are important in control of SARS-CoV infection (2010) J Virol, 84, pp. 1289-1301; Page, C., Goicochea, L., Matthews, K., Induction of alternatively activated macrophages enhances pathogenesis during severe acute respiratory syndrome coronavirus infection (2012) J Virol, 86, pp. 13334-13349; Tazaki, T., Tabata, K., Ainai, A., Shape-dependent adjuvanticity of nanoparticle conjugated RNA adjuvants for intranasal inactivated influenza vaccines (2018) RSC Adv, 8, pp. 16527-16536; Mottram, P.L., Leong, D., Crimeen-Irwin, B., Type 1 and 2 immunity following vaccination is influenced by nanoparticle size: formulation of a model vaccine for respiratory syncytial virus (2007) Mol Pharmaceutics, 4, pp. 73-84; Leenaars, M., Hendriksen, C.F., Critical steps in the production of polyclonal and monoclonal antibodies: evaluation and recommendations (2005) ILAR J, 46, pp. 269-279","Nagata, N.; Department of Pathology, National Institute of Infectious DiseasesJapan; email: nnagata@nih.go.jp",,Blackwell Publishing Asia,3855600,,MIIMD,31692019,English,Microbiol. Immunol.,Article,Final,Open Access,Scopus,2-s2.0-85075138721,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Kannan S., Shaik Syed Ali P., Sheeza A., Hemalatha K.",14045178800;55425849200;56736984800;55224158000;,COVID-19 (Novel Coronavirus 2019) - recent trends,2020,European Review for Medical and Pharmacological Sciences,24,4,,2006,2011,,,10.26355/eurrev_202002_20378,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081529817&doi=10.26355%2feurrev_202002_20378&partnerID=40&md5=347e5679478f7d5d7713291f39f7b06f,"School of Medicine, Maldives National University, Male', Maldives; Department of Laboratory Sciences and Pathology, Jimma University, Jimma, Ethiopia","Kannan, S., School of Medicine, Maldives National University, Male', Maldives; Shaik Syed Ali, P., School of Medicine, Maldives National University, Male', Maldives; Sheeza, A., School of Medicine, Maldives National University, Male', Maldives; Hemalatha, K., Department of Laboratory Sciences and Pathology, Jimma University, Jimma, Ethiopia","The World Health Organization (WHO) has issued a warning that, although the 2019 novel coronavirus (COVID-19) from Wuhan City (China), is not pandemic, it should be contained to prevent the global spread. The COVID-19 virus was known earlier as 2019-nCoV. As of 12 February 2020, WHO reported 45,171 cases and 1115 deaths related to COVID-19. COVID-19 is similar to Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) virus in its pathogenicity, clinical spectrum, and epidemiology. Comparison of the genome sequences of COVID-19, SARS-CoV, and Middle East Respiratory Syndrome coronavirus (MERS-CoV) showed that COVID-19 has a better sequence identity with SARS-CoV compared to MERS CoV. However, the amino acid sequence of COVID-19 differs from other coronaviruses specifically in the regions of 1ab polyprotein and surface glycoprotein or S-protein. Although several animals have been speculated to be a reservoir for COVID-19, no animal reservoir has been already confirmed. COVID-19 causes COVID-19 disease that has similar symptoms as SARSCoV. Studies suggest that the human receptor for COVID-19 may be angiotensin-converting enzyme 2 (ACE2) receptor similar to that of SARSCoV. The nucleocapsid (N) protein of COVID-19 has nearly 90% amino acid sequence identity with SARS-CoV. The N protein antibodies of SARS-CoV may cross react with COVID-19 but may not provide cross-immunity. In a similar fashion to SARS-CoV, the N protein of COVID-19 may play an important role in suppressing the RNA interference (RNAi) to overcome the host defense. This mini-review aims at investigating the most recent trend of COVID-19. © 2020 Verduci Editore s.r.l. All rights reserved.",2019-nCoV; Coronavirus; COVID-19; MERS; Novel coronavirus 2019; Pneumonia; SARS,"nucleocapsid protein; viral protein; COVID-19; nucleocapsid protein; severe acute respiratory syndrome coronavirus 2; Article; coronavirus disease 2019; Coronavirus infection; host resistance; human; incidence; laboratory diagnosis; nonhuman; RNA interference; sustained virologic response; trend study; virus genome; World Health Organization; animal; Betacoronavirus; chemistry; genetics; metabolism; virus activation; virus pneumonia; Animals; Betacoronavirus; Coronavirus Infections; Genome, Viral; Humans; Nucleocapsid Proteins; Pneumonia, Viral; Virus Activation; World Health Organization","Munster, V.J., Koopmans, M., van Doremalen, N., van Riel, D., de Wit, E., A novel coronavirus emerging in China - Key questions for impact assessment N Engl J Med, 2020. , Jan 24.: Epub ahead of print; Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., Zhao, X., Tan, W., A novel coronavirus from patients with pneumonia in China, 2019 N Engl J Med, 2020. , Jan 24.: Epub ahead of print; Zhou, P., Yang, X.L., Wang, X.G., Hu, B., Zhang, L., Zhang, W., Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin Nature, 2020. , https://doi.org/10.1038/s41586-020-2012-7; Fraire, A.E., Woda, B.A., Welsh, R.M., Kradin, R.L., Coronavirus (2014) Viruses and the Lung: Infections and Non-Infectious Viral-Linked Lung Disorders, p. XIV. , Eds. Springer-Verlag Berlin Heidelberg 243; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 20, pp. 30183-30185; Wu, F., Zhao, S., Yu, B., Chen, Y.M., Wang, W., Hu, Y., Complete genome characterisation of a novel coronavirus associated with severe human respiratory disease in Wuhan, China bioRxiv 2020, , https://doi.org/10.1101/2020.01.24.919183; Zhao, Y., Zhao, Z., Wang, Y., Zhou, Y., Ma, Y., Zuo, W., Single-Cell RNA Expression Profiling of ACE2, the Putative Receptor of Wuhan 2019-nCov. bioRxiv 2020, , https://doi.org/10.1101/2020.01.26.919985; Letko, M., Munster, V., Functional Assessment of Cell Entry and Receptor Usage for Lineage B Â-Coronaviruses, including 2019-nCoV. bioRxiv 2020, , https://doi.org/10.1101/2020.01.22.915660; Dong, N., Yang, X., Ye, L., Chen, K., Chan, E.W., Yang, M., Genomic and protein structure modelling analysis depicts the origin and infectivity of 2019-nCoV, a new coronavirus which caused a pneumonia outbreak in Wuhan, China bioRxiv 2020, , https://doi.org/10.1101/2020.01.20.913368; Perlman, S., Another decade, another coronavirus N Engl J Med, p. 2020. , Epub ahead of print abstract available; Gralinski, L.E., Menachery, V.D., Return of the coronavirus: 2019-Ncov Viruses 2020, 12. , pii: E135; Cui, L., Wang, H., Ji, Y., Yang, J., Xu, S., Huang, X., Wang, Z., Chen, Y., The nucleocapsid protein of coronaviruses acts as a viral suppressor of RNA silencing in nammalian nells (2015) J Virol, 89, pp. 9029-9043; Ding, S.W., RNA-based antiviral immunity (2010) Nat Rev Immunol, 10, pp. 632-644; Sullivan, C.S., Ganem, D., A virus-encoded inhibitor that blocks RNA interference in mammalian cells (2005) J Virol, 79, pp. 7371-7379; Maillard, P.V., Ciaudo, C., Marchais, A., Li, Y., Jay, F., Ding, S.W., Voinnet, O., Antiviral RNA interference in mammalian cells (2013) Science, 342, pp. 235-238; Ali, P.S., John, J., Selvaraj, M., Kek, T.L., Salleh, M.Z., Nodamura virus B2 amino terminal domain sensitivity to small interfering RNA (2015) Microbiol Immunol, 59, pp. 299-304; Read, J.M., Bridgen, J.R., Cummings, D.A., Ho, A., Jewell, C.P., Novel coronavirus 2019-nCoV: Early estimation of epidemiological parameters and epidemic predictions medRxiv 2020, , https://doi.org/10.1101/2020.01.23.20018549; Mahase, E., China coronavirus: What do we know so far? (2020) BMJ, 368, p. m308; Lu, H., Stratton, C.W., Tang, Y., Outbreak of pneumonia of unknown etiology in Wuhan China: The mystery and the miracle J Med Virol, 2020. , Epub ahead of print; Nishiura, H., Jung, S.M., Linton, N.M., Kinoshita, R., Yang, Y., Hayashi, K., Kobayashi, T., Akhmetzhanov, A.R., The extent of transmission of novel Coronavirus in Wuhan, China, 2020 (2020) J Clin Med, 9. , pii: E330; Chen, Y., Liu, Q., Guo, D., Emerging coronaviruses: Genome structure, replication, and pathogenesis J Med Virol, 2020. , Epub ahead of print; Chan, J.F., Yuan, S., Kok, K.H., To, K.K., Chu, H., Yang, J., Xing, F., Yuen, K.Y., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: A study of a family cluster Lancet, 2020. , S0140-6736(20)30154-9, Epub ahead of print; Hui, D.S., Azhar, I.E., Madani, T.A., Ntoumi, F., Kock, R., Dar, O., Ippolito, G., Petersen, E., The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health - The latest 2019 novel coronavirus outbreak in Wuhan, China (2020) Int J Infect Dis, 91, pp. 264-266; Ji, W., Wang, W., Zhao, X., Zai, J., Li, X., Homologous recombination within the spike glycoprotein of the newly identified coronavirus may boost cross-species transmission from snake to human J Med Virol, 2020. , Epub ahead of print; Guo, Q., Li, M., Wang, C., Fang, Z., Wang, P., Tan, J., Host and infectivity prediction of Wuhan 2019 novel coronavirus using deep learning algorithm bioRxiv 2020, , https://doi.org/10.1101/2020.01.21.914044; Riou, J., Althaus, C.L., Pattern of early human-to-human transmission of Wuhan 2019 novel coronavirus (2019-nCoV), December 2019 to January 2020 Euro Surveill 2020, 25; Chen, T.M., Rui, J., Wang, Q.P., Zhao, Z.Y., Cui, J.A., Yin, L., A mathematical model for simulating the transmission of Wuhan novel Coronavirus bioRxiv 2020, , https://doi.org/10.1101/2020.01.19.911669; Wu, P., Hao, X., Lau, E.H.Y., Wong, J.Y., Leung, K.S.M., Wu, J.T., Cowling, B.J., Leung, G.M., Real-time tentative assessment of the epidemiological characteristics of novel coronavirus infections in Wuhan, China, as at 22 January 2020 Euro Surveill 2020, 25; Who: Novel Coronavirus (2019-nCoV) advice for the public Novel Coronavirus (2019-nCoV) Advice for, p. 2020. , World Health Organization. the public; Cyranoski, D., This scientist hopes to test coronavirus drugs on animals in locked-down Wuhan (2020) Nature, 577, p. 607; Corman, V.M., Landt, O., Kaiser, M., Molenkamp, R., Meijer, A., Chu, D.K., Bleicker, T., Drosten, C., Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR (2020) Euro Surveill, 25","Kannan, S.; School of Medicine, Maldives National UniversityMaldives; email: Kannan.subbaram@mnu.edu.mv",,Verduci Editore s.r.l,11283602,,RESFD,32141569,English,Eur. Rev. Med. Pharmacol. Sci.,Article,Final,,Scopus,2-s2.0-85081529817,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Arshad Ali S., Baloch M., Ahmed N., Arshad Ali A., Iqbal A.",57215935774;57212495550;57202624872;57215931610;57215933969;,The outbreak of Coronavirus Disease 2019 (COVID-19)—An emerging global health threat,2020,Journal of Infection and Public Health,,,,,,,,10.1016/j.jiph.2020.02.033,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082404937&doi=10.1016%2fj.jiph.2020.02.033&partnerID=40&md5=aadd9e0f89c47ddc8e385309d3189252,"Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan","Arshad Ali, S., Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan; Baloch, M., Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan; Ahmed, N., Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan; Arshad Ali, A., Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan; Iqbal, A., Dow Medical College, Dow University of Health Sciences, Karachi, Pakistan","The outbreak of Coronavirus Disease 2019 (COVID-19) causing novel coronavirus-infected pneumonia (NCIP), has affected the lives of 71,429 people globally. Originating in China, the disease has a rapid progression to other countries. Research suggests remarkable genomic resemblance of 2019-nCoV with Severe Acute Respiratory Syndrome (SARS) which has a history of a pandemic in 2002. With evidence of nosocomial spread, a number of diligent measures are being employed to constrain its propagation. Hence, the Public Health Emergency of International Concern (PHEIC) has been established by the World Health Organization (WHO) with strategic objectives for public health to curtail its impact on global health and economy. © 2020 The Authors",Infectious disease; Novel coronavirus; Pandemic; Public health; Zoonotic transmission,,"The 2019-nCoV Outbreak Joint Field Epidemiology Investigation Team, Qun Li, An outbreak of NCIP (2019-nCoV) infection in China — Wuhan, Hubei Province, 2019−2020 (2020) China CDC Wkly, 2 (5), p. 790; World Health Organization, https://www.who.int/docs/defaultsource/coronaviruse/situation-reports/20200217-sitrep-28-covid-19.pdf, Coronavirus Disease 2019 (COVID-19) Situation Report – 28.Who.int.2020. Available from: [Accessed 18 February 2020]; Battegay, M., Kuehl, R., Tschudin-Sutter, S., Hirsch, H.H., Widmer, A.F., Neher, R.A., 2019-novel Coronavirus (2019-nCoV): estimating the case fatality rate — a word of caution (2020) Swiss Med Wkly, 150. , Published 2020 Feb 7; Chen, Y., Liu, Q., Guo, D., Emerging coronaviruses: genome structure, replication, and pathogenesis (2020) J Med Virol; Paules, C.I., Marston, H.D., Fauci, A.S., Coronavirus infections—more than just the common cold (2020) JAMA, 323 (8), pp. 707-708; Wu, J.T., Leung, K., Leung, G.M., Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study (2020) Lancet, 395 (10225), pp. 689-697; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Cheng, Z., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395 (10223), pp. 497-506; RaboResearch - Economic Research, Economic implications of the coronavirus (2020), https://economics.rabobank.com/publications/2020/january/economic-implications-of-the-coronavirus, [online]. Available at: /. [Accessed 10 February 2020]; You, C., Lin, Q., Zhou, X.-H., An estimation of the total number of cases of NCIP (2019-nCoV) — wuhan, Hubei Province, 2019–2020 (2020) China CDC Wkly, 2 (6), pp. 87-91; Li, J., Li, J.J., Xie, X., Cai, X., Huang, J., Tian, X., Zhu, H., Game consumption and the 2019 novel coronavirus (2020) Lancet Infect Dis, 20 (3), pp. 275-276; World Health Organization, Statement on the second meeting of the international health regulations (2005), https://www.who.int/news-room/detail/30-01-2020-statement-on-the-second-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-outbreak-of-novel-coronavirus-(2019-ncov, Emergency Committee regarding the outbreak of novel coronavirus (2019-nCoV). Who.int. Available from: ). [Accessed 31 January 2020]; World Health Organization, https://www.who.int/news-room/detail/05-02-2020-us-675-million-needed-for-new-coronavirus-preparedness-and-response-global-plan, US$675 million needed for new coronavirus preparedness and response global plan. [online] Available at: [Accessed 10 February 2020]","Arshad Ali, S.; Dow Medical College, Dow University of Health SciencesPakistan; email: shajeeaarshadali@gmail.com",,Elsevier Ltd,18760341,,,32199792,English,J. Infect. Public Health,Article,Article in Press,Open Access,Scopus,2-s2.0-85082404937,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Lu Q., Shi Y.",35211474900;57215682275;,Coronavirus disease (COVID-19) and neonate: What neonatologist need to know,2020,Journal of Medical Virology,,,,,,,1,10.1002/jmv.25740,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081734247&doi=10.1002%2fjmv.25740&partnerID=40&md5=0474a10f9e8be7310a8545a516b34ea5,"Department of Neonatology, Key Laboratory of Pediatrics in Chongqing, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital, Chongqing Medical University, Chongqing, China","Lu, Q., Department of Neonatology, Key Laboratory of Pediatrics in Chongqing, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital, Chongqing Medical University, Chongqing, China; Shi, Y., Department of Neonatology, Key Laboratory of Pediatrics in Chongqing, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital, Chongqing Medical University, Chongqing, China","Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cause china epidemics with high morbidity and mortality, the infection has been transmitted to other countries. About three neonates and more than 230 children cases are reported. The disease condition of the main children was mild. There is currently no evidence that SARS-CoV-2 can be transmitted transplacentally from mother to the newborn. The treatment strategy for children with Coronavirus disease (COVID-19) is based on adult experience. Thus far, no deaths have been reported in the pediatric age group. This review describes the current understanding of COVID-19 infection in newborns and children. © 2020 Wiley Periodicals, Inc.",,,"Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382 (8), pp. 727-733; Wang, C., Horby, P.W., Hayden, F.G., Gao, G.F., A novel coronavirus outbreak of global health concern (2020) Lancet, 395 (10223), pp. 470-473; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395 (10223), pp. 497-506; Latest developments in epidemic control of 2019-nCoV; Lu, R., Zhao, X., Li, J., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet, 395 (10224), pp. 565-574; Wu, F., Zhao, S., Yu, B., A new coronavirus associated with human respiratory disease in China (2020) Nature, , https://doi.org/10.1038/s41586-020-2008-3; GiorgiCarmine, C., Federico, M., Genomic variance of the 2019-nCoV coronavirus (2020) bioRxiv, , https://doi.org/10.1101/2020.02.02.931162; Lam, T.T.-Y., Shum, M.H.-H., Zhu, H.-C., Identification of 2019-nCoV related coronaviruses in Malayan pangolins in southern China (2020) bioRxiv, , https://doi.org/10.1101/2020.02.13.945485; National Adiministration of Traditional Chinese Medicine. Handbook of Prevention and Treatment of the Pneumonia Caused by the Novel Coronavirus (2019-nCoV) (Trial version 5); Hoffmann, M., Kleine-Weber, H., Krüger, N., Müller, M., Drosten, C., Pöhlmann, S., The novel coronavirus 2019 (2019-nCoV) uses the SARS-coronavirus receptor2 ACE2 and the cellular protease TMPRSS2 for entry into target cells (2020) bioRxiv, , https://doi.org/10.1101/2020.01.31.929042; Zhang, H., Kang, Z., Gong, H., The digestive system is a potential route of 2019-nCov infection: a bioinformatics analysis based on single-cell transcriptomes (2020) bioRxiv, , https://doi.org/10.1101/2020.01.30.927806; Zhang, Q., Cong, M., Wang, N., Association of angiotensin-converting enzyme 2 gene polymorphism and enzymatic activity with essential hypertension in different gender: a case-control study (2018) Medicine, 97 (42); Zhao, Y., Zhao, Z., Wang, Y., Zhou, Y., Ma, Y., Zuo, W., Single-cell RNA expression profiling of ACE2, the putative receptor of Wuhan 2019-nCov (2020) bioRxiv, , https://doi.org/10.1101/2020.01.26.91998510; Zhang, W., Du, R.H., Li, B., Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes (2020) Emerg Microbes Infect, 9 (1), pp. 386-389; Principi, N., Bosis, S., Esposito, S., Effects of coronavirus infections in children (2010) Emerg Infect Dis, 16 (2), pp. 183-188; Zumla, A., Hui, D.S., Perlman, S., Middle East respiratory syndrome (2015) Lancet, 386 (9997), pp. 995-1007; Chen, H., Guo, J., Wang, C., Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records (2020) The Lancet; Lauer, S.A., Grantz, K.H., Bi, Q., The incubation period of 2019-nCoV from publicly reported confirmed cases: estimation and application (2020) Med Rxiv, , https://doi.org/10.1101/2020.02.02.20020016; Recommendation for the diagnosis and treatment of novel coronavirus infection/pneumonia in children in Hubei (Trial version 2); Li, A.M., Ng, P.C., Severe acute respiratory syndrome (SARS) in neonates and children (2005) Arch Dis Child Fetal Neonatal Ed, 90 (6), pp. F461-F465; Lingkong, Z., Xuwei, T., Wenhao, Y., Wang, J., Liu, X., Liu, Z., First case of neonate infected with novel coronavirus pneumonia in China (2020) Chin J Pediatr, 58. , E009; Cai, J., Wang, X., Ge, Y., First case of 2019 novel coronavirus infection in children in Shanghai (2020) Zhonghua Er Ke Za Zhi, 58 (2), pp. 86-87; Deng, H., Zhang, Y., Wang, Y., Li, F., Two cases of 2019 novel coronavirus infection in children (2020) Chin Pediatr Emerg Med, 27 (22), pp. 81-83; Jie, Y., Li, M., Aihua, S., Yihong, P., 2019 novel coronavirus (2019-nCoV) and 2019-nCoV pneumonia (2020) Chin J Microbiol Immunol, 40 (1), pp. 1-6; Gao, Z., Efficient management of novel coronavirus pneumonia by efficient prevention and control in scientific manner (2020) Chin J Tubere Respir Dis, 43. , E001-E001; Chinese expert consensus on the perinatal and neonatal management for the prevention and control of the 2019 novel coronavirus infection (First edition) Annals of Translational Medicine, , https://doi.org/10.21037/atm.2020.02.20; Chinese Journal of Pediatrics. Recommendations for the diagnosis, prevention and control of the 2019 novel coronavirus infection in children (first interim edition) (2020) Chin J Pediatr, 58 (3), pp. 169-174; Holshue, M.L., DeBolt, C., Lindquist, S., First case of 2019 novel coronavirus in the United States (2020) N Engl J Med, 382 (10), pp. 929-936; Khalid, M., Al Rabiah, F., Khan, B., Al Mobeireek, A., Butt, T.S., Al Mutairy, E., Ribavirin and interferon-α2b as primary and preventive treatment for Middle East respiratory syndrome coronavirus: a preliminary report of two cases (2015) Antivir Ther, 20 (1), pp. 87-91; Danesh, A., Cameron, C.M., León, A.J., Early gene expression events in ferrets in response to SARS coronavirus infection versus direct interferon-alpha2b stimulation (2011) Virology, 409 (1), pp. 102-112; Zhou, Y., Hou, Y., Shen, J., Huang, Y., Martin, W., Cheng, F., Network-based drug repurposing for human coronavirus medRxiv, , https://doi.org/10.1101/2020.02.03.20020263; Mair-Jenkins, J., Saavedra-Campos, M., Baillie, J.K., The effectiveness of convalescent plasma and hyperimmune immunoglobulin for the treatment of severe acute respiratory infections of viral etiology: a systematic review and exploratory meta-analysis (2015) J Infect Dis, 211 (1), pp. 80-90","Lu, Q.; Department of Neonatology, Key Laboratory of Pediatrics in Chongqing, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital, Chongqing Medical UniversityChina; email: qilu_qi@hotmail.com",,John Wiley and Sons Inc.,1466615,,JMVID,32115733,English,J. Med. Virol.,Review,Article in Press,Open Access,Scopus,2-s2.0-85081734247,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Ralph R., Lew J., Zeng T., Francis M., Xue B., Roux M., Ostadgavahi A.T., Rubino S., Dawe N.J., Al-Ahdal M.N., Kelvin D.J., Richardson C.D., Kindrachuk J., Falzarano D., Kelvin A.A.",57214793766;57206691868;56522454300;57205644481;57214795334;57214800000;56964324600;55240504800;57205181372;7003765745;7006326577;7402506135;6507134040;13411417100;6603814164;,"2019-nCoV (Wuhan virus), a novel Coronavirus: Human-to-human transmission, travel-related cases, and vaccine readiness",2020,Journal of Infection in Developing Countries,14,1,,3,17,,2,10.3855/jidc.12425,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079141403&doi=10.3855%2fjidc.12425&partnerID=40&md5=bb143bf2c90d69e8457201d45f98cb38,"Vaccine and Infectious Disease Organization - International Vaccine Centre (VIDO-InterVac), Saskatoon, SK, Canada; Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, SK, Canada; International Institute of Infection and Immunity, Shantou University Medical College, Shantou, Guangdong, China; Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada; Sezione di Microbiologia Sperimentale e Clinica, Dipartimento di Scienze Biomediche, Università degli Studi di Sassari, Sassari, Italy; Department of Infection and Immunity, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia; Canadian Centre for Vaccinology, IWK Health Centre, Halifax, NS, Canada; Laboratory of Emerging and Re-Emerging Viruses, Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada; Department of Pediatrics, Division of Infectious Disease, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada","Ralph, R., Vaccine and Infectious Disease Organization - International Vaccine Centre (VIDO-InterVac), Saskatoon, SK, Canada, Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, SK, Canada; Lew, J., Vaccine and Infectious Disease Organization - International Vaccine Centre (VIDO-InterVac), Saskatoon, SK, Canada; Zeng, T., International Institute of Infection and Immunity, Shantou University Medical College, Shantou, Guangdong, China; Francis, M., Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada; Xue, B., International Institute of Infection and Immunity, Shantou University Medical College, Shantou, Guangdong, China, Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada; Roux, M., Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada; Ostadgavahi, A.T., Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada; Rubino, S., Sezione di Microbiologia Sperimentale e Clinica, Dipartimento di Scienze Biomediche, Università degli Studi di Sassari, Sassari, Italy; Dawe, N.J., Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada; Al-Ahdal, M.N., Department of Infection and Immunity, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia; Kelvin, D.J., International Institute of Infection and Immunity, Shantou University Medical College, Shantou, Guangdong, China, Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada, Canadian Centre for Vaccinology, IWK Health Centre, Halifax, NS, Canada; Richardson, C.D., Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada, Canadian Centre for Vaccinology, IWK Health Centre, Halifax, NS, Canada; Kindrachuk, J., Laboratory of Emerging and Re-Emerging Viruses, Department of Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada; Falzarano, D., Vaccine and Infectious Disease Organization - International Vaccine Centre (VIDO-InterVac), Saskatoon, SK, Canada, Department of Veterinary Microbiology, University of Saskatchewan, Saskatoon, SK, Canada; Kelvin, A.A., Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada, Canadian Centre for Vaccinology, IWK Health Centre, Halifax, NS, Canada, Department of Pediatrics, Division of Infectious Disease, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada","On 31 December 2019 the Wuhan Health Commission reported a cluster of atypical pneumonia cases that was linked to a wet market in the city of Wuhan, China. The first patients began experiencing symptoms of illness in mid-December 2019. Clinical isolates were found to contain a novel coronavirus with similarity to bat coronaviruses. As of 28 January 2020, there are in excess of 4,500 laboratory-confirmed cases, with > 100 known deaths. As with the SARS-CoV, infections in children appear to be rare. Travel-related cases have been confirmed in multiple countries and regions outside mainland China including Germany, France, Thailand, Japan, South Korea, Vietnam, Canada, and the United States, as well as Hong Kong and Taiwan. Domestically in China, the virus has also been noted in several cities and provinces with cases in all but one provinence. While zoonotic transmission appears to be the original source of infections, the most alarming development is that human-to-human transmission is now prevelant. Of particular concern is that many healthcare workers have been infected in the current epidemic. There are several critical clinical questions that need to be resolved, including how efficient is human-to-human transmission? What is the animal reservoir? Is there an intermediate animal reservoir? Do the vaccines generated to the SARS-CoV or MERS-CoV or their proteins offer protection against 2019-nCoV? We offer a research perspective on the next steps for the generation of vaccines. We also present data on the use of in silico docking in gaining insight into 2019-nCoV Spike-receptor binding to aid in therapeutic development. Diagnostic PCR protocols can be found at https://www.who.int/health-topics/coronavirus/laboratory-diagnostics-for-novel-coronavirus. Copyright © 2020 Ralph et al.",2019-nCoV; Coronavirus; Human-to-human transmission; Vaccine readiness; Wuhan,"2019 novel coronavirus; 2019 novel coronavirus infection; adult respiratory distress syndrome; Article; chill; China; computer model; Coronavirinae; Coronavirus infection; disease course; disease transmission; disseminated intravascular clotting; dyspnea; fever; headache; health care personnel; human; infectious disease medicine; knowledge; lymphocytopenia; malaise; medical research; Middle East respiratory syndrome coronavirus; nonhuman; pathogenesis; phylogeny; public health; receptor binding; SARS coronavirus; thrombocytopenia; travel related disease; university hospital; vaccination; virology; virus isolation; virus replication; animal; Betacoronavirus; chemistry; Coronavirus infection; disease carrier; genetics; pandemic; sequence analysis; travel; vaccination; veterinary medicine; virus pneumonia; zoonosis; COVID-19; severe acute respiratory syndrome coronavirus 2; viral protein; Animals; Betacoronavirus; Coronavirus Infections; Disease Reservoirs; Disease Transmission, Infectious; Humans; Pandemics; Pneumonia, Viral; Sequence Analysis, Protein; Travel; Vaccination; Viral Proteins; Zoonoses","Press Conference on Pneumonia Prevention and Control of the New Coronavirus Infection Held 10 Am Beijing Time, , https://www.scio.gov.cn/xwfbh/xwbfbh/wqfbh/42311/42470/index.htm, China, TSCIOotPsRo; (2019) 6864153 Undiagnosed Pneumonia - China (Hubei): Request for Information, , ProMed International Soceity for Infectious Diseases, PISfI, ProMed 20191230; (2020) Diseases, P.I.S.F.I. 20200102.6866757 Undiagnosed Pneumonia - China (Hubei) (01): Wildlife Sales, Market Closed, , Request for Information; Diseases, P.I.S.F.I. 20200103.6869668 Undiagnosed pneumonia - China (Hubei) (02): Updates, other countries responses (2020) Request for Information; (2020) Diseases, P.I.S.F.I. 20200105.6872267 Undiagnosed Pneumonia - China (Hubei) (03): Updates, Severe Acute Respiratory Syndrome, Middle East Respiratory Syndrome Rouled Rouled out, , WHO, Request for Information; (2020) Diseases, P.I.S.F.I. 20200108.6877694 Undiagnosed Pneumonia - China (Hubei), , 05): Novel Coronavirus identified; (2020) Diseases, P.I.S.F.I. 20200108.6878869 Undiagnosed Pneumonia - China (HU) (07): Official Confirmation of Novel Coronavirus; (2020) Diseases, P.I.S.F.I. 20200110.6881082 Undiagnosed Pneumonia - China (Hubei), , 08): Novel Coronavirus, WHO; (2020) Diseases, P.I.S.F.I. 20200110.6883253 Undiagnosed Pneumonia - China (Hubei) (09): Novel Coronavirus, More Iformation, First Fatality; (2020) Diseases, P.I.S.F.I. 20200113.6886644 Novel Coronavirus (02): Thailand Ex China (Hubei) WHO; (2020) Diseases, P.I.S.F.I. 20200114.6889527 Novel Coronavirus (04): China (Hubei), , Thailand ex China, WHO; (2020) Diseases, P.I.S.F.I. 20200115.6891515 Novel Coronavirus (05): China (HU), , Japan ex China; (2020) Diseases, P.I.S.F.I. 20200120.6899007 Novel Coronavirus (11) - China (Hubei) South Korea Ex China; (2020) Diseases, P.I.S.F.I. 20200121.6901757 Novel Coronavirus (12): China (Hubei) New Fatality, , healthcare workers, WHO; 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Infect. Dev. Ctries.,Article,Final,Open Access,Scopus,2-s2.0-85079141403,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Han Y., Yang H.",57215683588;57069187000;,The transmission and diagnosis of 2019 novel coronavirus infection disease (COVID-19): A Chinese perspective,2020,Journal of Medical Virology,,,,,,,1,10.1002/jmv.25749,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081694707&doi=10.1002%2fjmv.25749&partnerID=40&md5=5a8fc50dfa260f350abaf37ec6f9bc36,"Department of First Clinical Medical College, Shanxi Medical University, Taiyuan, Shanxi, China; Department of Obstetrics, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China","Han, Y., Department of First Clinical Medical College, Shanxi Medical University, Taiyuan, Shanxi, China; Yang, H., Department of Obstetrics, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China","2019 novel coronavirus (SARS-CoV-2), which originated in Wuhan, China, has attracted the world's attention over the last month. The Chinese government has taken emergency measures to control the outbreak and has undertaken initial steps in the diagnosis and treatment of 2019 novel coronavirus infection disease (COVID-19). However, SARS-CoV-2 possesses powerful pathogenicity as well as transmissibility and still holds many mysteries that are yet to be solved, such as whether the virus can be transmitted by asymptomatic patients or by mothers to their infants. 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Virol.,Article,Article in Press,Open Access,Scopus,2-s2.0-85081694707,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Li S., Huang W., Liao X., Li D., Du L., Song J., Zhou Y., Zhao S., Wang Y., Cao X., Wang J., Liu J., Wang Y., Zhu S., Li L., Hao Q., Zong Z., Sun X., Li W.",55622629400;55565475800;8320293500;55756424900;54419963400;57197826842;57215049137;55854070800;57209317800;57215071580;57215074350;57215072464;57215075270;57125189800;57213346455;32167493600;7007006581;55568207100;55718755500;,Disease control of 2019-novel coronavirus infection in hospital: West China urgent recommendation [新型冠状病毒感染医院内防控的华西紧急推荐],2020,Chinese Journal of Evidence-Based Medicine,20,2,,125,133,,,10.7507/1672-2531.202001121,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079762182&doi=10.7507%2f1672-2531.202001121&partnerID=40&md5=a1851dd565452ddb8a90c7353dc00aca,"Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, 610041, China; Chinese Evidence-based Medicine Center and MAGIC-China Center, West China Hospital, Sichuan University, Chengdu, 610041, China; Department of Infection Control, West China Hospital, Sichuan University, Chengdu, 610041, China; Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China; Department of Respiratory Medicine and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China; Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, 610041, China; Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China; Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China; Outpatient Department, West China Hospital, Sichuan University, Chengdu, 610041, China; Nursing Department, West China Hospital, Sichuan University, Chengdu, 610041, China; National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, China","Li, S., Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, 610041, China, Chinese Evidence-based Medicine Center and MAGIC-China Center, West China Hospital, Sichuan University, Chengdu, 610041, China; Huang, W., Department of Infection Control, West China Hospital, Sichuan University, Chengdu, 610041, China; Liao, X., Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China; Li, D., Department of Respiratory Medicine and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China; Du, L., Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, 610041, China; Song, J., Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China; Zhou, Y., Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China; Zhao, S., Outpatient Department, West China Hospital, Sichuan University, Chengdu, 610041, China; Wang, Y., Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, 610041, China; Cao, X., Nursing Department, West China Hospital, Sichuan University, Chengdu, 610041, China; Wang, J., Chinese Evidence-based Medicine Center and MAGIC-China Center, West China Hospital, Sichuan University, Chengdu, 610041, China; Liu, J., Chinese Evidence-based Medicine Center and MAGIC-China Center, West China Hospital, Sichuan University, Chengdu, 610041, China; Wang, Y., Chinese Evidence-based Medicine Center and MAGIC-China Center, West China Hospital, Sichuan University, Chengdu, 610041, China; Zhu, S., Department of Infection Control, West China Hospital, Sichuan University, Chengdu, 610041, China; Li, L., Chinese Evidence-based Medicine Center and MAGIC-China Center, West China Hospital, Sichuan University, Chengdu, 610041, China; Hao, Q., National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, China; Zong, Z., Department of Infection Control, West China Hospital, Sichuan University, Chengdu, 610041, China; Sun, X., Chinese Evidence-based Medicine Center and MAGIC-China Center, West China Hospital, Sichuan University, Chengdu, 610041, China, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, China; Li, W., Department of Respiratory Medicine and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China","China is facing the serious situation of 2019-novel coronavirus (2019-nCoV) infection. The health care institutions have actively participated in the prevention, diagnosis, and treatment of the disease. Proper regulation of in-hospital policy may help control virus spreading. We developed seven key clinical questions about the prevention and control of 2019-novel coronavirus infection in a hospital, and provided recommendations based on the best available evidence and expert experience. We interpret the recommendations for better feasibility in Chinese hospital. We hope to provide evidence and reference for the domestic medical institutions to reasonably adjust the hospital workflow during 2019-nCoV infection period. © 2020 West China University of Medical Science. 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J. Evid.-Based Med.,Review,Final,,Scopus,2-s2.0-85079762182,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Liu C., Zhou Q., Li Y., Garner L.V., Watkins S.P., Carter L.J., Smoot J., Gregg A.C., Daniels A.D., Jervey S., Albaiu D.",57215902263;57215902708;57215901733;57215900973;57211564086;57215900985;57215901971;57215904534;57215900157;57215901656;57215900342;,Research and Development on Therapeutic Agents and Vaccines for COVID-19 and Related Human Coronavirus Diseases,2020,ACS Central Science,,,,,,,1,10.1021/acscentsci.0c00272,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082319526&doi=10.1021%2facscentsci.0c00272&partnerID=40&md5=917ec857e58b4a9dad1fe10b75308e57,"CAS, A Division of the American Chemical Society, Columbus, OH 43210, United States","Liu, C., CAS, A Division of the American Chemical Society, Columbus, OH 43210, United States; Zhou, Q., CAS, A Division of the American Chemical Society, Columbus, OH 43210, United States; Li, Y., CAS, A Division of the American Chemical Society, Columbus, OH 43210, United States; Garner, L.V., CAS, A Division of the American Chemical Society, Columbus, OH 43210, United States; Watkins, S.P., CAS, A Division of the American Chemical Society, Columbus, OH 43210, United States; Carter, L.J., CAS, A Division of the American Chemical Society, Columbus, OH 43210, United States; Smoot, J., CAS, A Division of the American Chemical Society, Columbus, OH 43210, United States; Gregg, A.C., CAS, A Division of the American Chemical Society, Columbus, OH 43210, United States; Daniels, A.D., CAS, A Division of the American Chemical Society, Columbus, OH 43210, United States; Jervey, S., CAS, A Division of the American Chemical Society, Columbus, OH 43210, United States; Albaiu, D., CAS, A Division of the American Chemical Society, Columbus, OH 43210, United States","Since the outbreak of the novel coronavirus disease COVID-19, caused by the SARS-CoV-2 virus, this disease has spread rapidly around the globe. Considering the potential threat of a pandemic, scientists and physicians have been racing to understand this ew virus and the pathophysiology of this disease to uncover possible treatment regimens and discover effective therapeutic agents and vaccines. To support the current research and development, CAS has produced a special report to provide an overview of published cientific information with an emphasis on patents in the CAS content collection. It highlights antiviral strategies involving small molecules and biologics targeting complex molecular interactions involved in coronavirus infection and replication. The drug-repurposing effort documented herein focuses primarily on agents known to be effective against other RNA viruses including SARS-CoV and MERS-CoV. The patent analysis of coronavirusrelated biologics includes therapeutic antibodies, cytokines, and nucleic acid-based therapies targeting virus gene expression as well as various types of vaccines. More than 500 patents disclose methodologies of these four biologics with the potential for treating and preventing coronavirus infections, which may be applicable to COVID-19. The information included in this report rovides a strong intellectual groundwork for the ongoing development of therapeutic agents and vaccines. © 2020 American Chemical Society.",,Gene expression; Nucleic acids; Patents and inventions; Vaccines; Viruses; Coronaviruses; Patent analysis; Pathophysiology; Potential threats; Research and development; Small molecules; Therapeutic agents; Therapeutic antibodies; Diseases,"Gorbalenya, A.E., The species severe acute respiratory syndrome-related coronavirus: Classifying 2019-nCoV and naming it SARS-CoV-2 (2020) Nature Microbiology; Kupferschmidt, K., Cohen, J., Will novel virus go pandemic or be contained? 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Sin., , [Epub ahead of print]; Donoghue, M., Hsieh, F., Baronas, E., Godbout, K., Gosselin, M., Stagliano, N., Donovan, M., Acton, S., A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin i to angiotensin 1-9 (2000) Circ. Res., 87 (5), p. 426; Imai, Y., Kuba, K., Rao, S., Huan, Y., Guo, F., Guan, B., Yang, P., Penninger, J.M., Angiotensin-converting enzyme 2 protects from severe acute lung failure (2005) Nature, 436 (7047), pp. 112-116; Tipnis, S.R., Hooper, N.M., Hyde, R., Karran, E., Christie, G., Turner, A.J., A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase (2000) J. Biol. Chem., 275 (43), pp. 33238-33243; De Witt, B.J., Garrison, E.A., Champion, H.C., Kadowitz, P.J., L-163,491 is a partial angiotensin AT(1) receptor agonist in the hindquarters vascular bed of the cat (2000) Eur. J. Pharmacol., 404 (12), pp. 213-219; Guo, D., Old weapon for new enemy: Drug repurposing for treatment of newly emerging viral diseases (2020) Virol. Sin., , [Epub ahead of print]; Maxmen, A., More than 80 clinical trials launch to test coronavirus treatments (2020) Nature, 578 (7795), pp. 347-348; Arabi, Y.M., Shalhoub, S., Mandourah, Y., Al-Hameed, F., Al-Omari, A., Al Qasim, E., Jose, J., Fowler, R., Ribavirin and Interferon Therapy for Critically Ill Patients with Middle East Respiratory Syndrome: A Multicenter Observational Study (2019) Clin. Infect. 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Treat., 2, pp. 125-133; Zhou, Y., Vedantham, P., Lu, K., Agudelo, J., Carrion, R., Nunneley, J.W., Barnard, D., Simmons, G., Protease inhibitors targeting coronavirus and filovirus entry (2015) Antiviral Res., 116, pp. 76-84; Kumar, V., Shin, J.S., Shie, J.-J., Ku, K.B., Kim, C., Go, Y.Y., Huang, K.-F., Liang, P.-H., Identification and evaluation of potent Middle East respiratory syndrome coronavirus (MERS-CoV) 3CLPro inhibitors (2017) Antiviral Res., 141, pp. 101-106; Anand, K., Coronavirus Main Proteinase (3CLpro) Structure: Basis for Design of Anti-SARS Drugs (2003) Science, 300 (5626), pp. 1763-1767; Li, F., Structure of SARS Coronavirus Spike Receptor-Binding Domain Complexed with Receptor (2005) Science, 309 (5742), pp. 1864-1868; Bisht, H., Roberts, A., Vogel, L., Subbarao, K., Moss, B., Neutralizing antibody and protective immunity to SARS coronavirus infection of mice induced by a soluble recombinant polypeptide containing an N-terminal segment of the spike glycoprotein (2005) Virology, 334 (2), pp. 160-165; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Cao, B., Clinical features of patients infected with 2019 novel coronavirus in Wuhan (2020) Lancet, 395, pp. 497-506; Yang, Z.-Y., Huang, Y., Ganesh, L., Leung, K., Kong, W.-P., Schwartz, O., Subbarao, K., Nabel, G.J., PH-dependent entry of severe acute respiratory syndrome coronavirus is mediated by the spike glycoprotein andenhanced by dendritic cell transfer through DC-SIGN (2004) J. 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U. S. A., 101 (26), pp. 9804-9809; GlaxoSmithKline Press Release on 2/24/20, , https://www.gsk.com/en-gb/media/press-releases/clover-and-gsk-announce-research-collaboration-to-evaluate-coronavirus-covid-19-vaccine-candidate-with-pandemic-adjuvant-system; Generex Press Release on 2/27/20, , https://storage.googleapis.com/wzukusers/user-26831283/documents/5e57ed391b286sVf68Kq/PR_Generex_Coronavirus_Update_2_27_2020.pdf; Novavax Press Release on 2/26/20, , http://ir.novavax.com/news-releases/news-release-details/novavax-advances-development-novel-covid-19-vaccine; Moderna Press Release on 2/24/2020, , https://investors.modernatx.com/news-releases/news-release-details/moderna-ships-mrna-vaccine-against-novel-coronavirus-mrna-1273; Modjarrad, K., Roberts, C.C., Mills, K.T., Castellano, A.R., Paolino, K., Muthumani, K., Reuschel, E.L., Maslow, J.N., Safety and immunogenicity of an anti-Middle East respiratory syndrome coronavirus DNA vaccine: A phase 1, open-label, single-arm, dose-escalation trial (2019) Lancet Infect. Dis., 19 (9), pp. 1013-1022; Inovio Accelerates Timeline for COVID-19 DNA Vaccine INO-4800, , http://ir.inovio.com/news-and-media/news/press-release-details/2020/Inovio-Accelerates-Timeline-for-COVID-19-DNA-Vaccine-INO-4800/default.aspx","Liu, C.; CAS, A Division of the American Chemical SocietyUnited States; email: cliu@cas.org",,American Chemical Society,23747943,,,,English,ACS Cent. Sci.,Article,Article in Press,Open Access,Scopus,2-s2.0-85082319526,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Kim J.-M., Chung Y.-S., Jo H.J., Lee N.-J., Kim M.S., Woo S.H., Park S., Kim J.W., Kim H.M., Han M.-G.",57192934192;57203291955;57215667381;55469303000;36680155600;57203804069;56097972400;57215675902;57007421900;57215071915;,Identification of coronavirus isolated from a patient in Korea with covid-19,2020,Osong Public Health and Research Perspectives,,1,,3,7,,1,10.24171/j.phrp.2020.11.1.02,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081566598&doi=10.24171%2fj.phrp.2020.11.1.02&partnerID=40&md5=dbd0fe84eda4bf1e5ecbde8aac70f199,"Division of Viral Diseases, Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control and Prevention, Cheongju, South Korea; Division of Biosafety Evaluation and Control, National Institute of Health, Korea Centers for Disease Control and Prevention, Cheongju, South Korea","Kim, J.-M., Division of Viral Diseases, Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control and Prevention, Cheongju, South Korea; Chung, Y.-S., Division of Viral Diseases, Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control and Prevention, Cheongju, South Korea; Jo, H.J., Division of Viral Diseases, Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control and Prevention, Cheongju, South Korea; Lee, N.-J., Division of Viral Diseases, Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control and Prevention, Cheongju, South Korea; Kim, M.S., Division of Viral Diseases, Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control and Prevention, Cheongju, South Korea; Woo, S.H., Division of Viral Diseases, Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control and Prevention, Cheongju, South Korea; Park, S., Division of Viral Diseases, Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control and Prevention, Cheongju, South Korea; Kim, J.W., Division of Biosafety Evaluation and Control, National Institute of Health, Korea Centers for Disease Control and Prevention, Cheongju, South Korea; Kim, H.M., Division of Viral Diseases, Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control and Prevention, Cheongju, South Korea; Han, M.-G., Division of Viral Diseases, Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control and Prevention, Cheongju, South Korea","Objectives: Following reports of patients with unexplained pneumonia at the end of December 2019 in Wuhan, China, the causative agent was identified as coronavirus (SARS-CoV-2), and the 2019 novel coronavirus disease was named COVID-19 by the World Health Organization. Putative patients with COVID-19 have been identified in South Korea, and attempts have been made to isolate the pathogen from these patients. Methods: Upper and lower respiratory tract secretion samples from putative patients with COVID-19 were inoculated onto cells to isolate the virus. Full genome sequencing and electron microscopy were used to identify the virus. Results: The virus replicated in Vero cells and cytopathic effects were observed. Full genome sequencing showed that the virus genome exhibited sequence homology of more than 99.9% with SARS-CoV-2 which was isolated from patients from other countries, for instance China. Sequence homology of SARS-CoV-2 with SARS-CoV, and MERS-CoV was 77.5% and 50%, respectively. Coronavirus-specific morphology was observed by electron microscopy in virus-infected Vero cells. Conclusion: SARS-CoV-2 was isolated from putative patients with unexplained pneumonia and intermittent coughing and fever. The isolated virus was named BetaCoV/Korea/KCDC03/2020. © 2020 Korea Centers for Disease Control and Prevention.",Coronavirus; COVID-19; Isolation; Pneumonia; SARS-CoV-2,2019 novel coronavirus; animal cell; Article; China; Coronavirinae; Coronavirus infection; cytopathogenic effect; disease control; human; in vitro study; inoculation; Korea; lower respiratory tract; Middle East respiratory syndrome coronavirus; nonhuman; priority journal; real time reverse transcription polymerase chain reaction; SARS coronavirus; sequence homology; serology; transmission electron microscopy; upper respiratory tract; Vero cell line; virus genome; virus isolation; virus pneumonia; virus replication; virus strain; whole genome sequencing,"Cui, J., Li, F., Shi, Z.L., Origin and evolution of pathogenic coronaviruses (2019) Nat Rev Microbiol, 17 (3), pp. 181-192; Monchatre-Leroy, E., Boue, F., Boucher, J.M., Identification of alpha and beta coronavirus in wildlife species in France: Bats, rodents, rabbits, and hedgehogs (2017) Viruses, 9 (12), p. 364; Cong, Y., Ren, X., Coronavirus entry and release in polarized epithelial cells: A review (2014) Rev Med Virol, 24 (5), pp. 308-315; Tortorici, M.A., Veesler, D., Structural insights into coronavirus entry (2019) Adv Virus Res, 105, pp. 93-116; Corman, V.M., Muth, D., Niemeyer, D., Hosts and sources of endemic human coronaviruses (2018) Adv Virus Res, 100, pp. 163-188; de Wit, E., van Doremalen, N., Falzarano, D., SARS and MERS: Recent insights into emerging coronaviruses (2016) Nat Rev Microbiol, 14 (8), pp. 523-534; Paraskevis, D., Kostaki, E.G., Magiorkinis, G., Full-genome evolutionary analysis of the novel corona virus (2019-nCoV) rejects the hypothesis of emergence as a result of a recent recombination event (2020) Infect Genet Evol, 79, p. 104212; Hui, D.S., I Azhar, E., Madani, T.A., The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health - The latest 2019 novel coronavirus outbreak in Wuhan, China (2020) Int J Infect Dis, 91, pp. 264-266; Rubin, E.J., Baden, L.R., Morrissey, S., Medical journals and the 2019-NCOV outbreak (2020) N Engl J Med, , Epub 2020 Jan 27. Epub ahead of print; Favre, G., Pomar, L., Musso, D., 2019-nCoV epidemic: What about pregnancies? (2020) Lancet, 395. , 10224; Pan, Y., Guan, H., Imaging changes in patients with 2019-nCov (2020) Eur Radiol, , Epub 2020 Feb 6. Epub ahead of print; Corman, V.M., Landt, O., Kaiser, M., Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR (2020) Euro Surveil, 25 (3), p. 2000045; Zhou, P., Yang, X.L., Wang, X.G., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature, , Epub 2020 Feb 3. Epub ahead of print; Hua, Y., Laserstein, P., Helmstaedter, M., Large-volume en-bloc staining for electron microscopy-based connectomics (2015) Nat Commun, 6, p. 7923; Jan, M.O., Bridget, B., Susan, C., Morphogenesis of coronavirus HCoV-NL63 in Cell Culture: A transmission electron microscopic study (2008) Open Infect Dis J, 2, pp. 52-58; Zhu, A., Zhang, D.Z., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382 (8), pp. 727-733","Han, M.-G.; Division of Viral Diseases, Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control and PreventionSouth Korea; email: mghan@korea.kr",,Korea Centers for Disease Control and Prevention,22109099,,,,English,Osong Public Health Res. Perspect.,Article,Final,Open Access,Scopus,2-s2.0-85081566598,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Cárdenas-Conejo Y., Liñan-Rico A., García-Rodríguez D.A., Centeno-Leija S., Serrano-Posada H.",36968458500;54392101700;57215839735;16244316600;57215842534;,An exclusive 42 amino acid signature in pp1ab protein provides insights into the evolutive history of the 2019 novel human-pathogenic coronavirus (SARS-CoV-2),2020,Journal of Medical Virology,,,,,,,,10.1002/jmv.25758,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082073585&doi=10.1002%2fjmv.25758&partnerID=40&md5=4eaedc12c455da7f4eeb039e768c3416,"Laboratory of Agrobiotechnology, National Council of Science and Technology (CONACYT)-University of Colima, Colima, Colima, Mexico; University Center for Biomedical Research, National Council of Science and Technology (CONACYT)-University of Colima, Colima, Colima, Mexico; Laboratory of Agrobiotechnology, University of Colima, Colima, Colima, Mexico","Cárdenas-Conejo, Y., Laboratory of Agrobiotechnology, National Council of Science and Technology (CONACYT)-University of Colima, Colima, Colima, Mexico; Liñan-Rico, A., University Center for Biomedical Research, National Council of Science and Technology (CONACYT)-University of Colima, Colima, Colima, Mexico; García-Rodríguez, D.A., Laboratory of Agrobiotechnology, University of Colima, Colima, Colima, Mexico; Centeno-Leija, S., Laboratory of Agrobiotechnology, National Council of Science and Technology (CONACYT)-University of Colima, Colima, Colima, Mexico; Serrano-Posada, H., Laboratory of Agrobiotechnology, National Council of Science and Technology (CONACYT)-University of Colima, Colima, Colima, Mexico","The city of Wuhan, Hubei province, China, was the origin of a severe pneumonia outbreak in December 2019, attributed to a novel coronavirus (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]), causing a total of 2761 deaths and 81109 cases (25 February 2020). SARS-CoV-2 belongs to genus Betacoronavirus, subgenus Sarbecovirus. The polyprotein 1ab (pp1ab) remains unstudied thoroughly since it is similar to other sarbecoviruses. In this short communication, we performed phylogenetic-structural sequence analysis of pp1ab protein of SARS-CoV-2. The analysis showed that the viral pp1ab has not changed in most isolates throughout the outbreak time, but interestingly a deletion of 8 aa in the virulence factor nonstructural protein 1 was found in a virus isolated from a Japanese patient that did not display critical symptoms. While comparing pp1ab protein with other betacoronaviruses, we found a 42 amino acid signature that is only present in SARS-CoV-2 (AS-SCoV2). Members from clade 2 of sarbecoviruses have traces of this signature. The AS-SCoV2 located in the acidic-domain of papain-like protein of SARS-CoV-2 and bat-SL-CoV-RatG13 guided us to suggest that the novel 2019 coronavirus probably emerged by genetic drift from bat-SL-CoV-RaTG13. The implication of this amino acid signature in papain-like protein structure arrangement and function is something worth to be explored. © 2020 Wiley Periodicals, Inc.",coronavirus; pp1ab protein; SARS; SARS-CoV-2; virus; Wuhan,,"Wu, F., Zhao, S., Yu, B., A new coronavirus associated with human respiratory disease in China (2020) Nature, 579, pp. 265-269. , https://doi.org/10.1038/s41586-020-2008-3; Ji, W., Wang, W., Zhao, X., Zai, J., Li, X., Homologous recombination within the spike glycoprotein of the newly identified coronavirus may boost cross-species transmission from snake to human (2020) J Med Virol, 92, pp. 433-440. , https://doi.org/10.1002/jmv.25682; Chan, J.F.-W., Kok, K.-H., Zhu, Z., Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan (2020) Emerg Microbes Infect, 9, pp. 221-236. , https://doi.org/10.1080/22221751.2020.1719902; Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382, pp. 727-733. , https://doi.org/10.1056/NEJMoa2001017; Lu, R., Zhao, X., Li, J., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet, 395, pp. 565-574. , https://doi.org/10.1016/S0140-6736(20)30251-8; Zhou, P., Yang, X.-L., Wang, X.-G., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature, 579, pp. 270-273. , https://doi.org/10.1038/s41586-020-2012-7; Báez-Santos, Y.M., St., John, S.E., Mesecar, A.D., The SARS-coronavirus papain-like protease: structure, function, and inhibition by designed antiviral compounds (2020) Antiviral Res. Elsevier B.V, 115, pp. 21-38. , https://doi.org/10.1016/j.antiviral.2014.12.015; Argüello-Astorga, G., Herrera-Estrella, L., Evolution of light-regulated plant promoters (1998) Annu Rev Plant Physiol Plant Mol Biol, 9, pp. 525-555. , https://doi.org/10.1146/annurev.arplant.49.1.525; Hagemeijer, M.C., Rottier, P.J.M., Haan, C.A.M., Biogenesis and dynamics of the coronavirus replicative structures (2012) Viruses, 4, pp. 3245-3269. , https://doi.org/10.3390/v4113245; Züst, R., Cervantes-Barragán, L., Kuri, T., Coronavirus non-structural protein 1 Is a major pathogenicity factor: implications for the rational design of coronavirus vaccines (2007) PLoS Pathog, 3. , https://doi.org/10.1371/journal.ppat.0030109; Serrano, P., Johnson, M.A., Almeida, M.S., Nuclear magnetic resonance structure of the N-terminal domain of nonstructural protein 3 from the severe acute respiratory syndrome coronavirus (2007) J Virol, 81, pp. 12049-12060. , https://doi.org/10.1128/JVI.00969-07","Cárdenas-Conejo, Y.; Laboratory of Agrobiotechnology, National Council of Science and Technology (CONACYT)-University of ColimaMexico; email: ycardenasco@conacyt.mx",,John Wiley and Sons Inc.,1466615,,JMVID,32167166,English,J. Med. Virol.,Article,Article in Press,Open Access,Scopus,2-s2.0-85082073585,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Kothai R., Arul B.",10539423000;10541210600;,"2019 novel coronavirus: A mysterious threat from Wuhan, China–A current review",2020,International Journal of Research in Pharmaceutical Sciences,11,Special Issue 1,,7,15,,,10.26452/ijrps.v11iSPL1.1975,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081741973&doi=10.26452%2fijrps.v11iSPL1.1975&partnerID=40&md5=46011f19e59b1e3b89faf02630dc7aee,"Department of Pharmacy Practice, Vinayaka Mission’s College of Pharmacy, Vinayaka Mission’s Research Foundation (Deemed to be University), Salem, Tamil Nadu 636008, India","Kothai, R., Department of Pharmacy Practice, Vinayaka Mission’s College of Pharmacy, Vinayaka Mission’s Research Foundation (Deemed to be University), Salem, Tamil Nadu 636008, India; Arul, B., Department of Pharmacy Practice, Vinayaka Mission’s College of Pharmacy, Vinayaka Mission’s Research Foundation (Deemed to be University), Salem, Tamil Nadu 636008, India","Coronaviruses (CoV) are a huge family of viruses and they cause various diseases from the common cold to very serious illnesses. They also just like the Middle East Respiratory Syndrome (MERS-CoV) and Severe Acute Respiratory Syndrome (SARS-CoV). But novel coronavirus (nCoV) is a different strain and newly discovered in humans. Several known coronaviruses circulate in animals not yet infected by humans. It is also a zoonotic virus, which means that they are spread between animals and then to humans. Comprehensive studies showed that SARS-CoV was transmitted to humans by civet cats and MERS-CoV by dromedary camels. Respiratory symptoms, fever, cough, shortness of breath and difficulty in breathing are common signs of infection. It was started from Huanan wholesale seafood market with the admission of 2-3 patients and now crossed 37251 cases with 812 deaths as on 9th February. In some of the days, the number of new admissions was more than 3000 cases continuously. This review summarises the types, morphology, origin, transmission, symptoms, diagnostic methods, Chinese, global and Indian scenario of this novel deadly virus. The world health organization advises for the public about the avoiding of the spread of the virus, general recommendations for individuals and for the risk groups also reviewed. © International Journal of Research in Pharmaceutical Sciences and 2020 | All rights reserved.",Coronavirus; Global Scenario; Types; WHO recommendations,alanine aminotransferase; aspartate aminotransferase; nucleocapsid protein; virus envelope protein; virus RNA; virus spike protein; 2019 novel coronavirus; acute respiratory tract disease; aerosol; artificial ventilation; Betacoronavirus; China; common cold; computer assisted tomography; coronavirus disease 2019; coughing; diarrhea; dyspnea; electron microscopy; epidemic; fever; growth rate; human; Human coronavirus 229E; Human coronavirus HKU1; Human coronavirus NL63; Human coronavirus OC43; immunocompromised patient; leukocytosis; leukopenia; lymphocytopenia; Middle East respiratory syndrome coronavirus; nonhuman; patient care; pneumonia; real time reverse transcription polymerase chain reaction; Review; rhinorrhea; SARS coronavirus; thorax pain; virus envelope; virus isolation; virus nucleocapsid; virus transmission; weakness,"Abdul-Rasool, S., Fielding, B.C., Understanding Human Coronavirus HCoV-NL63~!2009-11-13~!2010-04-09~!2010-05-25~! 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Viruses, pp. 806-828; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Cao, B., (2020) Clinical Features of Patients Infected with 2019 Novel Coronavirus in Wuhan, pp. 30183-30188; Ji, J.S., Origins of MERS-CoV, and lessons for 2019-nCoV (2020) The Lancet Planetary Health; Lau, S.K.P., Lee, P., Tsang, A.K.L., Yip, C.C.Y., Tse, H., Lee, R.A., So, L.Y., Yuen, K.Y., Molecular Epidemiology of Human Coronavirus OC43 Reveals Evolution of Different Genotypes over Time and Recent Emergence of a Novel Genotype due to Natural Recombination (2011) Journal of Virology, 85 (21), pp. 11325-11337; Lee, F.E., Treanor, H., Broaddus, J.J.V.C., Mason, R.J., Ernst, J.D., King, T.E., Lazarus, S.C., 32-Viral Infections (2016) Murray and Nadel’s Textbook of Respiratory Medicine, pp. 527-556. , W.B. Saunders. Philadelphia; Li, F., Structure of SARS Coronavirus Spike Receptor-Binding Domain Complexed with Receptor (2005) Science, 309 (5742), pp. 1864-1868; Szelazek, B., Kabala, W., Kus, K., Zdzalik, M., Twarda-Clapa, A., Golik, P., Burmistrz, M., Dubin, G., Structural Characterization of Human Coronavirus NL63 N (2017) Protein. Journal of Virology, 91 (11), pp. e02503-e02516; Vassilara, F., Spyridaki, A., Pothitos, G., Deliveliotou, A., Papadopoulos, A., A Rare Case of Human Coronavirus 229E Associated with Acute Respiratory Distress Syndrome in a Healthy Adult (2018) Case Reports in Infectious Diseases, 2018, pp. 1-4; Novel Coronavirus (2020) Situation Reports, pp. 1-20; (2020) WHO Recommendations to Reduce Risk of Transmission of Emerging Pathogens from Animals to Humans in Live Animal Markets, , World Health Organizations; Woo, P., Lau, S., Yip, C., Huang, Y., Yuen, K.Y., More and More Coronaviruses: Human Coronavirus HKU1 (2009) Viruses, 1, pp. 57-71; Zhou, W., Wang, W., Wang, H., Lu, R., Tan, W., First infection by all four non-severe acute respiratory syndrome human coronaviruses takes place during childhood (2013) BMC Infectious Diseases, 13 (1), p. 433; Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., Tan, W., A Novel Coronavirus from Patients with Pneumonia in China (2019) New England Journal of Medicine, 382 (8), pp. 727-733","Arul, B.; Department of Pharmacy Practice, Vinayaka Mission’s College of Pharmacy, Vinayaka Mission’s Research Foundation (Deemed to be University)India; email: arul1971@yahoo.com",,J. K. Welfare and Pharmascope Foundation,9757538,,,,English,Int. J. Res. Pharm. Sci.,Review,Final,Open Access,Scopus,2-s2.0-85081741973,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Lai C.-C., Liu Y.H., Wang C.-Y., Wang Y.-H., Hsueh S.-C., Yen M.-Y., Ko W.-C., Hsueh P.-R.",57214801883;57215782303;57215773855;57210707373;57205475327;57139774100;57216141184;7103390478;,"Asymptomatic carrier state, acute respiratory disease, and pneumonia due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): Facts and myths",2020,"Journal of Microbiology, Immunology and Infection",,,,,,,4,10.1016/j.jmii.2020.02.012,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081693256&doi=10.1016%2fj.jmii.2020.02.012&partnerID=40&md5=799b8fc6d2ebc05b401954a853c8cdeb,"Department of Internal Medicine, Kaohsiung Veterans General Hospital, Tainan Branch, Tainan, Taiwan; Department of Internal Medicine, Cardinal Tien Hospital and School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan; Medical Research Center, Cardinal Tien Hospital and School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan; Department of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Section of Infectious Diseases, Taipei City Hospital, Taipei, Taiwan; Department of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan; Department of Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan","Lai, C.-C., Department of Internal Medicine, Kaohsiung Veterans General Hospital, Tainan Branch, Tainan, Taiwan; Liu, Y.H., Department of Internal Medicine, Cardinal Tien Hospital and School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan; Wang, C.-Y., Department of Internal Medicine, Cardinal Tien Hospital and School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan; Wang, Y.-H., Medical Research Center, Cardinal Tien Hospital and School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan; Hsueh, S.-C., Department of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Yen, M.-Y., Section of Infectious Diseases, Taipei City Hospital, Taipei, Taiwan, Department of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan; Ko, W.-C., Department of Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Hsueh, P.-R., Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan, Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan","Since the emergence of coronavirus disease 2019 (COVID-19) (formerly known as the 2019 novel coronavirus [2019-nCoV]) in Wuhan, China in December 2019, which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), more than 75,000 cases have been reported in 32 countries/regions, resulting in more than 2000 deaths worldwide. Despite the fact that most COVID-19 cases and mortalities were reported in China, the WHO has declared this outbreak as the sixth public health emergency of international concern. The COVID-19 can present as an asymptomatic carrier state, acute respiratory disease, and pneumonia. Adults represent the population with the highest infection rate; however, neonates, children, and elderly patients can also be infected by SARS-CoV-2. In addition, nosocomial infection of hospitalized patients and healthcare workers, and viral transmission from asymptomatic carriers are possible. The most common finding on chest imaging among patients with pneumonia was ground-glass opacity with bilateral involvement. Severe cases are more likely to be older patients with underlying comorbidities compared to mild cases. Indeed, age and disease severity may be correlated with the outcomes of COVID-19. To date, effective treatment is lacking; however, clinical trials investigating the efficacy of several agents, including remdesivir and chloroquine, are underway in China. Currently, effective infection control intervention is the only way to prevent the spread of SARS-CoV-2. © 2020",2019-nCoV; Acute respiratory disease; Asymptomatic carrier; Coronavirus; COVID-19; SARS-CoV-2; Wuhan pneumonia,,"https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200221-sitrep-32-covid-19.pdf?sfvrsn=4802d089_2, WHO. [Accessed on 21 February 2020]; Lee, P.I., Hsueh, P.R., Emerging threats from zoonotic coronaviruses-from SARS and MERS to 2019-nCoV (2020) J Microbiol Immunol Infect, (20), pp. 30011-30016. , pii: S1684-1182; Huang, W.H., Teng, L.C., Yeh, T.K., Chen, Y.J., Lo, W.J., Wu, M.J., 2019 novel coronavirus disease (COVID-19) in Taiwan: reports of two cases from Wuhan, China (2020) J Microbiol Immunol Infect; Liu, Y.C., Liao, C.H., Chang, C.F., Chou, C.C., Lin, Y.R., A locally transmitted case of SARS-CoV-2 infection in Taiwan (2020) N Engl J Med; Gorbalenya, A.E., Baker, S.C., Baric, R.S., de Groot, R.J., Drosten, C., Gulyaeva, A.A., Severe acute respiratory syndrome-related coronavirus: the species and its viruses – a statement of the Coronavirus Study Group (2020), 2020.02.07.937862; Lai, C.C., Shih, T.P., Ko, W.C., Tang, H.J., Hsueh, P.R., Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and corona virus disease-2019 (COVID-19): the epidemic and the challenges (2020) Int J Antimicrob Agents; Bai, Y., Yao, L., Wei, T., Tian, F., Jih, D.Y., Chen, L., Presumed asymptomatic carrier transmission of COVID-19 (2020) J Am Med Assoc; The epidemiological characteristics of an outbreak of 2019 novel coronavirus disease (COVID-19) – China (2020), China CDC Weekly; Rothe, C., Schunk, M., Sothmann, P., Bretzel, G., Froeschl, G., Wallrauch, C., Transmission of 2019-nCoV infection from an asymptomatic contact in Germany (2020) N Engl J Med; Yu, P., Zhu, J., Zhang, Z., Han, Y., Huang, L., A familial cluster of infection associated with the 2019 novel coronavirus indicating potential person-to-person transmission during the incubation period (2020) J Infect Dis, , pii: jiaa077; Guan, W.J., Ni, Z.Y., Hu, Y., Laing, W.H., Ou, C.Q., He, J.X., Clinical characteristics of 2019 novel coronavirus infection in China (2020) medRxiv, , preprint; Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395, pp. 507-513; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506; Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) J Am Med Assoc; Yang, Y., Lu, Q., Liu, M., Wang, Y., Zhang, A., Jalali, N., Epidemiological and clinical features of the 2019 novel coronavirus outbreak in China (2020) medRxiv; Ryu, S., Chun, B.C., An interim review of the epidemiological characteristics of 2019 novel coronavirus (2020) Epidemiol Health, 42, p. e2020006; Nishiura, H., Linton, N.M., Akhmetzhanov, A.R., Initial cluster of novel coronavirus (2019-nCoV) infections in Wuhan, China is consistent with substantial human-to-human transmission (2020) J Clin Med, 9, p. E488; Chen, H., Guo, J., Wang, C., Luo, F., Yu, X., Zhang, W., Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records (2020) Lancet; Chan, J.F., Yuan, S., Kok, K.H., To, K.K., Chu, H., Yang, J., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, 395, pp. 514-523; Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med; Backer, J.A., Klinkenberg, D., Wallinga, J., Incubation period of 2019 novel coronavirus (2019-nCoV) infections among travellers from Wuhan, China, 20-28 January 2020 (2020) Euro Surveill, 25 (5); Chang, X.H., Rebaza, A., Sharma, L., Dela Cruz, C.S., Protecting health-care workers from subclinical coronavirus infection (2020) Lancet Respir Med, , pii: S2213-2600(20)30066-30067; Liu, J., Liu, Y., Xiang, P., Pu, L., Xiong, H., Li, C., Neutrophil-to-lymphocyte ratio predicts severe illness patients with 2019 novel coronaviruse in the early stage (2020) medRxiv; Chung, M., Bernheim, A., Mei, X., Zhang, N., Huang, M., Zeng, X., CT imaging features of 2019 novel coronavirus (2019-nCoV) (2020) Radiology, p. 200230; Lei, J., Li, J., Li, X., Qi, X., CT Imaging of the 2019 novel coronavirus (2019-nCoV) pneumonia (2020) Radiology, p. 200236; Pan, Y., Guan, H., Imaging changes in patients with 2019-nCov (2020) Eur Radiol; Kanne, J.P., Chest CT findings in 2019 novel coronavirus (2019-nCoV) infections from Wuhan, China: key points for the radiologist (2020) Radiology, p. 200241; Pan, Y., Guan, H., Zhou, S., Wang, Y., Li, Q., Zhu, T., Initial CT findings and temporal changes in patients with the novel coronavirus pneumonia (2019-nCoV): a study of 63 patients in Wuhan, China (2020) Eur Radiol; Duan, Y.N., Qin, J., Pre- and posttreatment chest CT findings: 2019 novel coronavirus (2019-nCoV) pneumonia (2020) Radiology, p. 200323; Lu, H., Drug treatment options for the 2019-new coronavirus (2019-nCoV) (2020) Biosci Trends; Wang, M., Cao, R., Zhang, L., Yang, X., Liu, J., Xu, M., Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro (2020) Cell Res; Liu, W., Morse, J.S., Lalonde, T., Xu, S., Learning from the past: possible urgent prevention and treatment options for severe acute respiratory infections caused by 2019-nCoV (2020) ChemBioChem; Holshue, M.L., DeBolt, C., Lindquist, S., Lofy, K.H., Wiesman, J., Bruce, H., First case of 2019 novel coronavirus in the United States (2020) N Engl J Med; Ko, W.C., Rolain, J.M., Lee, N.Y., Chen, P.L., Huang, C.T., Lee, P.I., Arguments in favor of remdesivir for treating SARS-CoV-2 infections (2020) Int J Antimicrob Agents; Colson, P., Rolain, J.M., Raoult, D., Chloroquine for the 2019 novel coronavirus (2020) Int J Antimicrob Agents; Multicenter collaboration group of Department of Science and Technology of Guangdong Province and Health Commission of Guangdong Province for chloroquine in the treatment of novel coronavirus pneumonia. [Expert consensus on chloroquine phosphate for the treatment of novel coronavirus pneumonia] (2020) Zhonghua Jie He He Hu Xi Za Zhi, 43 (0), p. E019; Szűcs, Z., Kelemen, V., Le Thai, S., Csávás, M., Rőth, E., Batta, G., Structure-activity relationship studies of lipophilic teicoplanin pseudoaglycon derivatives as new anti-influenza virus agents (2018) Eur J Med Chem, 157, pp. 1017-1030; Zhou, N., Pan, T., Zhang, J., Li, Q., Zhang, X., Bai, C., Glycopeptide antibiotics potently inhibit cathepsin L in the late endosome/lysosome and block the entry of Ebola virus, middle east respiratory syndrome coronavirus (MERS-CoV), and severe acute respiratory syndrome coronavirus (SARS-CoV) (2016) J Biol Chem, 291, pp. 9218-9232; Balzarini, J., Keyaerts, E., Vijgen, L., Egberink, H., De Clercq, E., Van Ranst, M., Inhibition of feline (FIPV) and human (SARS) coronavirus by semisynthetic derivatives of glycopeptide antibiotics (2006) Antivir Res, 72, pp. 20-33; Arabi, Y.M., Mandourah, Y., Al-Hameed, F., Sindi, A.A., Almekhlafi, G.A., Hussein, M.A., Corticosteroid therapy for critically ill patients with middle east respiratory syndrome (2018) Am J Respir Crit Care Med, 197, pp. 757-767; Lee, N., Allen Chan, K.C., Hui, D.S., Ng, E.K., Wu, A., Chiu, R.W., Effects of early corticosteroid treatment on plasma SARS-associated coronavirus RNA concentrations in adult patients (2004) J Clin Virol, 31, pp. 304-309; Lee, D.T., Wing, Y.K., Leung, H.C., Sung, J.J., Ng, Y.K., Yiu, G.C., Factors associated with psychosis among patients with severe acute respiratory syndrome: a case-control study (2004) Clin Infect Dis, 39, pp. 1247-1249; Xiao, J.Z., Ma, L., Gao, J., Yang, Z.J., Xing, X.Y., Zhao, H.C., Glucocorticoid-induced diabetes in severe acute respiratory syndrome: the impact of high dosage and duration of methylprednisolone therapy (2004) Zhonghua Nei Ke Za Zhi, 43, pp. 179-182; Russell, C.D., Millar, J.E., Baillie, J.K., Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury (2020) Lancet, 395, pp. 473-475; Li, G., Fan, Y., Lai, Y., Han, T., Li, Z., Zhou, P., Coronavirus infections and immune responses (2020) J Med Virol, 92, pp. 424-432; Guo, L., Wei, D., Zhang, X., Wu, Y., Li, Q., Zhou, M., Clinical features predicting mortality risk in patients with viral pneumonia: the MuLBSTA score (2019) Front Microbiol, 10, p. 2752; Patel, A., Jernigan, D.B., 2019-nCoV CDC Response Team. Initial public health response and interim clinical guidance for the 2019 novel coronavirus outbreak – United States, December 31, 2019-February 4, 2020 (2020) MMWR – Morb Mortal Wkly Rep, 69, pp. 140-146; Yen, M.Y., Schwartz, J., Wu, J.S., Hsueh, P.R., Controlling Middle East respiratory syndrome: lessons learned from severe acute respiratory syndrome (2015) Clin Infect Dis, 61, pp. 1761-1762; Lee, P.I., Hu, Y.L., Chen, P.Y., Huang, Y.C., Hsueh, P.R., Are children less susceptible to COVID-19? (2020) J Microbiol Immunol Infect; Zou, L., Ruan, F., Huang, M., Liang, L., Huang, H., Hong, Z., SARS-CoV-2 viral load in upper respiratory specimens of infected patients (2020) N Engl J Med","Hsueh, P.-R.; Departments of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital, Number 7, Chung-Shan South Road, Taiwan; email: hsporen@ntu.edu.tw",,Elsevier Ltd,16841182,,JMIIF,,English,J. Microbiol. Immunol. Infect.,Review,Article in Press,Open Access,Scopus,2-s2.0-85081693256,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Malik Y.S., Sircar S., Bhat S., Sharun K., Dhama K., Dadar M., Tiwari R., Chaicumpa W.",55407524100;56107107400;57200857797;56297714300;6507396956;55854080700;55314856100;7006311280;,"Emerging novel coronavirus (2019-nCoV)—current scenario, evolutionary perspective based on genome analysis and recent developments",2020,Veterinary Quarterly,40,1,,68,76,,3,10.1080/01652176.2020.1727993,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080117464&doi=10.1080%2f01652176.2020.1727993&partnerID=40&md5=8865a7287514e6620669b8a28ffdfd34,"Division of Biological Standardization, ICAR-Indian Veterinary Research Institute, Bareilly, Uttar Pradesh, India; Division of Surgery, ICAR–Indian Veterinary Research Institute, Bareilly, Uttar Pradesh, India; Division of Pathology, ICAR–Indian Veterinary Research Institute, Bareilly, Uttar Pradesh, India; Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran; Department of Veterinary Microbiology and Immunology, College of Veterinary Sciences, Deen Dayal Upadhayay Pashu Chikitsa Vigyan Vishwavidyalay Evum Go-Anusandhan Sansthan (DUVASU), Mathura, India; Center of Research Excellence on Therapeutic Proteins and Antibody Engineering, Department of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand","Malik, Y.S., Division of Biological Standardization, ICAR-Indian Veterinary Research Institute, Bareilly, Uttar Pradesh, India; Sircar, S., Division of Biological Standardization, ICAR-Indian Veterinary Research Institute, Bareilly, Uttar Pradesh, India; Bhat, S., Division of Biological Standardization, ICAR-Indian Veterinary Research Institute, Bareilly, Uttar Pradesh, India; Sharun, K., Division of Surgery, ICAR–Indian Veterinary Research Institute, Bareilly, Uttar Pradesh, India; Dhama, K., Division of Pathology, ICAR–Indian Veterinary Research Institute, Bareilly, Uttar Pradesh, India; Dadar, M., Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran; Tiwari, R., Department of Veterinary Microbiology and Immunology, College of Veterinary Sciences, Deen Dayal Upadhayay Pashu Chikitsa Vigyan Vishwavidyalay Evum Go-Anusandhan Sansthan (DUVASU), Mathura, India; Chaicumpa, W., Center of Research Excellence on Therapeutic Proteins and Antibody Engineering, Department of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand","Coronaviruses are the well-known cause of severe respiratory, enteric and systemic infections in a wide range of hosts including man, mammals, fish, and avian. The scientific interest on coronaviruses increased after the emergence of Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) outbreaks in 2002-2003 followed by Middle East Respiratory Syndrome CoV (MERS-CoV). This decade’s first CoV, named 2019-nCoV, emerged from Wuhan, China, and declared as ‘Public Health Emergency of International Concern’ on January 30th, 2020 by the World Health Organization (WHO). As on February 4, 2020, 425 deaths reported in China only and one death outside China (Philippines). In a short span of time, the virus spread has been noted in 24 countries. The zoonotic transmission (animal-to-human) is suspected as the route of disease origin. The genetic analyses predict bats as the most probable source of 2019-nCoV though further investigations needed to confirm the origin of the novel virus. The ongoing nCoV outbreak highlights the hidden wild animal reservoir of the deadly viruses and possible threat of spillover zoonoses as well. The successful virus isolation attempts have made doors open for developing better diagnostics and effective vaccines helping in combating the spread of the virus to newer areas. © 2020, © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.",2019-nCoV; Coronavirus; genetic analyses; Middle East Respiratory Syndrome CoV; Public Health Emergency; reservoir host; Severe Acute Respiratory Syndrome CoV; therapeutics; vaccines; zoonoses,"monoclonal antibody; remdesivir; virus spike protein; virus vaccine; vitronectin; severe acute respiratory syndrome coronavirus 2; adult respiratory distress syndrome; Alphacoronavirus; Article; Avian infectious bronchitis virus; Betacoronavirus; bioinformatics; Bovine coronavirus; Canine coronavirus; Canine respiratory coronavirus; China; Coronavirus infection; Deltacoronavirus; disease surveillance; drug efficacy; drug safety; emergency care; Equine coronavirus; Gammacoronavirus; gene sequence; genetic variability; genome analysis; high throughput sequencing; human; infection control; Middle East respiratory syndrome coronavirus; nonhuman; novel coronavirus 2019; novel coronavirus disease 2019; novel coronavirus disease 2019; phylogeny; Porcine epidemic diarrhea virus; Porcine respiratory coronavirus; reverse transcription polymerase chain reaction; SARS coronavirus; sequence alignment; Transmissible gastroenteritis virus; virus genome; virus isolation; virus transmission; zoonosis; animal; bat; Betacoronavirus; classification; communicable disease; Coronavirus infection; disease carrier; genetics; pandemic; veterinary medicine; virology; zoonosis; Animals; Betacoronavirus; Chiroptera; Communicable Diseases, Emerging; Coronavirus Infections; Disease Reservoirs; Humans; Pandemics; Phylogeny; Zoonoses","Alagaili, A.N., Briese, T., Mishra, N., Kapoor, V., Sameroff, S.C., Burbelo, P.D., de Wit, E., Zalmout, I.S., Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia (2014) MBio, 5 (2), pp. e00884-00814; Cheng, V.C., Wong, S.-C., To, K.K., Ho, P., Yuen, K.-Y., Preparedness and proactive infection control measures against the emerging Wuhan coronavirus pneumonia in China (2020) J Hosp Infect, , [published online ahead of print, 2020 Jan 18]; Cohen, J., New coronavirus threat galvanizes scientists (2020) Science, , 367(6477): 492–493; Cui, J., Li, F., Shi, Z.-L., Origin and evolution of pathogenic coronaviruses (2019) Nat Rev Microbiol, 17 (3), pp. 181-192; Cyranoski, D., This scientist hopes to test coronavirus drugs on animals in locked-down Wuhan (2020) Nature, 577 (7792), p. 607; de Groot, R.J., Baker, S., Baric, R., Enjuanes, L., Gorbalenya, A., Holmes, K., Perlman, S., Talbot, P., Family coronaviridae (2012) In: King AMQ, Adams MJ, Cartens EB, Lefkowitz EJ (eds.), Virus Taxonomy, the 9th report of the International Committee on Taxonomy of Viruses. 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Preprint version; Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., Zhao, X., Lu, R., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med","Malik, Y.S.; Division of Biological Standardization, ICAR-Indian Veterinary Research InstituteIndia; email: malikyps@gmail.com",,Taylor and Francis Ltd.,1652176,,VEQUD,32036774,English,Vet. Q.,Article,Final,Open Access,Scopus,2-s2.0-85080117464,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Shanmugaraj B., Malla A., Phoolcharoen W.",55382181000;57014728200;26531746600;,Emergence of novel coronavirus 2019-nCoV: Need for rapid vaccine and biologics development,2020,Pathogens,9,2,148,,,,1,10.3390/pathogens9020148,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079848582&doi=10.3390%2fpathogens9020148&partnerID=40&md5=45b599feb6124e8909ab3b88d3cf3753,"Research unit for Plant-produced Pharmaceuticals, Chulalongkorn University, Bangkok, 10330, Thailand; Department of Pharmacognosy and Pharmaceutical Botany, Chulalongkorn University, Bangkok, 10330, Thailand","Shanmugaraj, B., Research unit for Plant-produced Pharmaceuticals, Chulalongkorn University, Bangkok, 10330, Thailand, Department of Pharmacognosy and Pharmaceutical Botany, Chulalongkorn University, Bangkok, 10330, Thailand; Malla, A., Research unit for Plant-produced Pharmaceuticals, Chulalongkorn University, Bangkok, 10330, Thailand, Department of Pharmacognosy and Pharmaceutical Botany, Chulalongkorn University, Bangkok, 10330, Thailand; Phoolcharoen, W., Research unit for Plant-produced Pharmaceuticals, Chulalongkorn University, Bangkok, 10330, Thailand, Department of Pharmacognosy and Pharmaceutical Botany, Chulalongkorn University, Bangkok, 10330, Thailand","Novel Coronavirus (2019-nCoV) is an emerging pathogen that was first identified in Wuhan, China in late December 2019. This virus is responsible for the ongoing outbreak that causes severe respiratory illness and pneumonia-like infection in humans. Due to the increasing number of cases in China and outside China, the WHO declared coronavirus as a global health emergency. Nearly 35,000 cases were reported and at least 24 other countries or territories have reported coronavirus cases as early on as February. Inter-human transmission was reported in a few countries, including the United States. Neither an effective anti-viral nor a vaccine is currently available to treat this infection. As the virus is a newly emerging pathogen, many questions remain unanswered regarding the virus’s reservoirs, pathogenesis, transmissibility, and much more is unknown. The collaborative efforts of researchers are needed to fill the knowledge gaps about this new virus, to develop the proper diagnostic tools, and effective treatment to combat this infection. Recent advancements in plant biotechnology proved that plants have the ability to produce vaccines or biopharmaceuticals rapidly in a short time. In this review, the outbreak of 2019-nCoV in China, the need for rapid vaccine development, and the potential of a plant system for biopharmaceutical development are discussed. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.",Biopharmaceuticals; Coronavirus; Emerging threat; Infectious diseases; Plant system; Transient expression; Viruses; Zoonoses,angiotensin converting enzyme 2; biological product; monoclonal antibody; recombinant antigen; recombinant protein; viral protein; virus vaccine; virus vector; 2019 novel coronavirus; Article; communicable disease; coronavirus disease 2019; coughing; drug industry; dyspnea; epidemic; fever; gene expression system; human; immune response; incubation time; mortality; nonhuman; transient expression; virus transmission,"Bloom, D.E., Cadarette, D., Infectious disease threats in the twenty-first century: Strengthening the global response (2019) Front. 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Dis, 210, pp. 200-208; Both, L., van Dolleweerd, C., Wright, E., Banyard, A.C., Bulmer-Thomas, B., Selden, D., Altmann, F., Ma, J.K., Production, characterization, and antigen specificity of recombinant 62-71-3, a candidate monoclonal antibody for rabies prophylaxis in humans (2013) FASEB J, 27, pp. 2055-2065; Phoolcharoen, W., Prehaud, C., van Dolleweerd, C.J., Both, L., da Costa, A., Lafon, M., Ma, J.K., Enhanced transport of plant-produced rabies single-chain antibody-RVG peptide fusion protein across an in cellulo blood-brain barrier device (2017) Plant Biotechnol. J., 15, pp. 1331-1339; http://mappbio.com, Mapp Biopharmaceutical, Inc, accessed on 8 February 2020; Park, J.G., Ye, C., Piepenbrink, M.S., Nogales, A., Wang, H., Shuen, M., Meyers, A.J., Kobie, J.J., A Broad and potent H1-specific human monoclonal antibody produced in plants prevents Influenza virus infection and transmission in Guinea Pigs (2020) Viruses, 12, p. 167; Rattanapisit, K., Srijangwad, A., Chuanasa, T., Sukrong, S., Tantituvanont, A., Mason, H.S., Nilubol, D., Phoolcharoen, W., Rapid transient production of a monoclonal antibody neutralizing the Porcine Epidemic Diarrhea Virus (PEDV) in Nicotiana benthamiana and Lactuca sativa (2017) Planta Med, 83, pp. 1412-1419; Hurtado, J., Acharya, D., Lai, H., Sun, H., Kallolimath, S., Steinkellner, H., Bai, F., Chen, Q., In vitro and in vivo efficacy of anti-chikungunya virus monoclonal antibodies produced in wild-type and glycoengineered Nicotiana benthamiana plants (2020) Plant Biotechnol. J., 18, pp. 266-273; Lai, H., He, J., Hurtado, J., Stahnke, J., Fuchs, A., Mehlhop, E., Gorlatov, S., Chen, Q., Structural and functional characterization of an anti-West Nile virus monoclonal antibody and its single-chain variant produced in glycoengineered plants (2014) Plant Biotechnol. J., 12, pp. 1098-1107; Paul, M.J., Thangaraj, H., Ma, J.K., Commercialization of new biotechnology: A systematic review of 16 commercial case studies in a novel manufacturing sector (2015) Plant Biotechnol. J., 13, pp. 1209-1220; Arntzen, C., Plant-made pharmaceuticals: FromEdible Vaccines to Ebola therapeutics (2015) Plant Biotechnol. J., 13, pp. 1013-1016; Song, Z., Xu, Y., Bao, L., Zhang, L., Yu, P., Qu, Y., Zhu, H., Qin, C., From SARS to MERS, Thrusting Coronaviruses into the Spotlight (2019) Viruses, 11, p. 59; Peiris, J.S., Guan, Y., Yuen, K.Y., Severe acute respiratory syndrome (2004) Nat. Med., 10, pp. S88-S97. , Suppl. 12; Li, F., Li, W., Farzan, M., Harrison, S.C., Structure of SARS coronavirus spike receptor-binding domain complexed with receptor (2005) Science, 309, pp. 1864-1868; Li, W., Moore, M.J., Vasilieva, N., Sui, J., Wong, S.K., Berne, M.A., Somasundaran, M., Greenough, T.C., Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus (2003) Nature, 426, pp. 450-454; Wan, Y., Shang, J., Graham, R., Baric, R.S., Li, F., Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS (2020) J. Virol.; Coughlin, M.M., Prabhakar, B.S., Neutralizing human monoclonal antibodies to severe acute respiratory syndrome coronavirus: Target, mechanism of action, and therapeutic potential (2012) Rev. Med. Virol., 22, pp. 2-17; Xu, J., Jia, W., Wang, P., Zhang, S., Shi, X., Wang, X., Zhang, L., Antibodies and vaccines against Middle East respiratory syndrome coronavirus (2019) Emerg. Microbes. Infect., 8, pp. 841-856; Yong, C.Y., Ong, H.K., Yeap, S.K., Ho, K.L., Tan, W.S., Recent Advances in the vaccine development against Middle East Respiratory Syndrome-Coronavirus (2019) Front. Microbiol., 10, p. 1781","Phoolcharoen, W.; Research unit for Plant-produced Pharmaceuticals, Chulalongkorn UniversityThailand; email: Waranyoo.P@chula.ac.th",,MDPI AG,20760817,,,,English,Pathogens,Article,Final,Open Access,Scopus,2-s2.0-85079848582,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Pan Y., Guan H., Zhou S., Wang Y., Li Q., Zhu T., Hu Q., Xia L.",56729525600;56657081200;57215023367;57215026598;57215028261;57212420407;57214312593;51566095600;,"Initial CT findings and temporal changes in patients with the novel coronavirus pneumonia (2019-nCoV): a study of 63 patients in Wuhan, China",2020,European Radiology,,,,,,,12,10.1007/s00330-020-06731-x,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079715573&doi=10.1007%2fs00330-020-06731-x&partnerID=40&md5=a3816ac551e0a189444f2027fc42351f,"Department of radiology, Tongji hospital, Huazhong University of Science and Technology, Wuhan, 430030, China","Pan, Y., Department of radiology, Tongji hospital, Huazhong University of Science and Technology, Wuhan, 430030, China; Guan, H., Department of radiology, Tongji hospital, Huazhong University of Science and Technology, Wuhan, 430030, China; Zhou, S., Department of radiology, Tongji hospital, Huazhong University of Science and Technology, Wuhan, 430030, China; Wang, Y., Department of radiology, Tongji hospital, Huazhong University of Science and Technology, Wuhan, 430030, China; Li, Q., Department of radiology, Tongji hospital, Huazhong University of Science and Technology, Wuhan, 430030, China; Zhu, T., Department of radiology, Tongji hospital, Huazhong University of Science and Technology, Wuhan, 430030, China; Hu, Q., Department of radiology, Tongji hospital, Huazhong University of Science and Technology, Wuhan, 430030, China; Xia, L., Department of radiology, Tongji hospital, Huazhong University of Science and Technology, Wuhan, 430030, China","Objectives: The purpose of this study was to observe the imaging characteristics of the novel coronavirus pneumonia. Methods: Sixty-three confirmed patients were enrolled from December 30, 2019 to January 31, 2020. High-resolution CT (HRCT) of the chest was performed. The number of affected lobes, ground glass nodules (GGO), patchy/punctate ground glass opacities, patchy consolidation, fibrous stripes and irregular solid nodules in each patient's chest CT image were recorded. Additionally, we performed imaging follow-up of these patients. Results: CT images of 63 confirmed patients were collected. M/F ratio: 33/30. The mean age was 44.9 ± 15.2 years. The mean number of affected lobes was 3.3 ± 1.8. Nineteen (30.2%) patients had one affected lobe, five (7.9%) patients had two affected lobes, four (6.3%) patients had three affected lobes, seven (11.1%) patients had four affected lobes while 28 (44.4%) patients had 5 affected lobes. Fifty-four (85.7%) patients had patchy/punctate ground glass opacities, 14 (22.2%) patients had GGO, 12 (19.0%) patients had patchy consolidation, 11 (17.5%) patients had fibrous stripes and 8 (12.7%) patients had irregular solid nodules. Fifty-four (85.7%) patients progressed, including single GGO increased, enlarged and consolidated; fibrous stripe enlarged, while solid nodules increased and enlarged. Conclusions: Imaging changes in novel viral pneumonia are rapid. The manifestations of the novel coronavirus pneumonia are diverse. Imaging changes of typical viral pneumonia and some specific imaging features were observed. Therefore, we need to strengthen the recognition of image changes to help clinicians to diagnose quickly and accurately. Key Points: • High-resolution CT (HRCT) of the chest is critical for early detection, evaluation of disease severity and follow-up of patients with the novel coronavirus pneumonia. • The manifestations of the novel coronavirus pneumonia are diverse and change rapidly. • Radiologists should be aware of the various features of the disease and temporal changes. © 2020, European Society of Radiology.","Coronavirus infections; Lung diseases; Pneumonia, viral; Thorax; Tomography, x-ray computed",,"Wang, C., Horby, P.W., Hayden, F.G., Gao, G.F., A novel coronavirus outbreak of global health concern (2020) Lancet.; Chen, Y., Liu, Q., Guo, D., Emerging coronaviruses: genome structure, replication, and pathogenesis (2020) J Med Virol; Chan, J.F., Yuan, S., Kok, K.H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: A study of a family cluster (2020) Lancet; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet; Tan, W., Zhao, X., Ma, X., A novel coronavirus genome identified in a cluster of pneumonia cases- Wuhan, China 2019−2020 (2020) China CDC Weekly, 2, pp. 61-62. , http://weekly.chinacdc.cn/en/article/id/a3907201-f64f-4154-a19e-4253b453d10c, Available via","Hu, Q.; Department of radiology, Tongji hospital, Huazhong University of Science and TechnologyChina; email: qjhu@outlook.com",,Springer,9387994,,EURAE,32055945,English,Eur. Radiol.,Article,Article in Press,Open Access,Scopus,2-s2.0-85079715573,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Tan Y.-T., Wang J.-W., Zhao K., Han L., Zhang H.-Q., Niu H.-Q., Shu K., Lei T.",57212342862;57215938220;57194276826;36107828900;57215933886;57215935196;8569251200;57202223456;,Preliminary Recommendations for Surgical Practice of Neurosurgery Department in the Central Epidemic Area of 2019 Coronavirus Infection,2020,Current Medical Science,,,,,,,,10.1007/s11596-020-2173-5,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082425074&doi=10.1007%2fs11596-020-2173-5&partnerID=40&md5=57c304f8a2cdc2be1bca6c05f8d24e9c,"Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China","Tan, Y.-T., Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China; Wang, J.-W., Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China; Zhao, K., Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China; Han, L., Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China; Zhang, H.-Q., Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China; Niu, H.-Q., Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China; Shu, K., Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China; Lei, T., Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China","Since December 2019, an outbreak of coronavirus disease 2019 (COVID-19) has posed significant threats to the public health and life in China. Unlike the other 6 identified coronaviruses, the SARS-Cov-2 has a high infectious rate, a long incubation period and a variety of manifestations. In the absence of effective treatments for the virus, it becomes extremely urgent to develop scientific and standardized proposals for prevention and control of virus transmission. Hereby we focused on the surgical practice in Neurosurgery Department, Tongji Hospital, Wuhan, and drafted several recommendations based on the latest relevant guidelines and our experience. These recommendations have helped us until now to achieve ‘zero infection’ of doctors and nurses in our department, we would like to share them with other medical staff of neurosurgery to fight 2019-nCoV infection. © 2020, Huazhong University of Science and Technology.",Diagnosis; Neurosurgery; Prevention; SARS-CoV-2; Treatment,,"Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395 (10223), pp. 507-513. , COI: 1:CAS:528:DC%2BB3cXhvFOmsb8%3D; Wu, F., Zhao, S.Y., A new coronavirus associated with human respiratory disease in China (2020) Nature; Pan, X., Ojcius, D.M., Gao, T., Lessons learned from the 2019-nCoV epidemic on prevention of future infectious diseases (2020) Microbes Infect; Sun, P., Lu, X., Xu, C., Understanding of COVID-19 based on current evidence (2020) J Med Virol; Zhao, W.M., Song, S.H., Chen, M.L., The 2019 novel coronavirus resource (2020) Yi Chuan, 42 (2), pp. 212-221. , PID: 32102777; Lu, R., Zhao, X., Li, J., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet, 395 (10224), pp. 565-574; Ralph, R., Lew, J., Zeng, T., 2019-nCoV (Wuhan virus), a novel Coronavirus: human-to-human transmission, travel-related cases, and vaccine readiness (2020) J Infect Dev Ctries, 14 (1), pp. 3-17; Wang, D., Hu, B., Hu, C., Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China (2020) JAMA; Lai, C.C., Shih, T.P., Ko, W.C., Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges (2020) Int J Antimicrob Agents, p. 105924; Ai, T., Yang, Z., Hou, H., Correlation of Chest CT and RT-PCR Testing in Coronavirus Disease 2019 (COVID-19) in China: A Report of 1014 Cases (2020) Radiology, p. 200642; Shanmugaraj, B., Malla, A., Phoolcharoen, W., Emergence of Novel Coronavirus 2019-nCoV: Need for Rapid Vaccine and Biologics Development (2020) Pathogens, 9 (2), pp. 148-150; Kwok, K.O., Wong, V., Wei, V.W.I., Novel coronavirus (2019-nCoV) cases in Hong Kong and implications for further spread (2020) J Infect","Shu, K.; Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyChina; email: Kshu@tjh.tjmu",,Huazhong University of Science and Technology,20965230,,,,English,Curr. Med. Sci.,Article,Article in Press,Open Access,Scopus,2-s2.0-85082425074,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Tang N., Li D., Wang X., Sun Z.",57204354898;7405326627;57211477952;37056491700;,Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia,2020,Journal of Thrombosis and Haemostasis,18,4,,844,847,,1,10.1111/jth.14768,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081755873&doi=10.1111%2fjth.14768&partnerID=40&md5=5c98a91a9b75f16befe508963099866c,"Department of Clinical Laboratory, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","Tang, N., Department of Clinical Laboratory, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Li, D., Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Wang, X., Department of Clinical Laboratory, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Sun, Z., Department of Clinical Laboratory, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","Background: In the recent outbreak of novel coronavirus infection in Wuhan, China, significantly abnormal coagulation parameters in severe novel coronavirus pneumonia (NCP) cases were a concern. Objectives: To describe the coagulation feature of patients with NCP. Methods: Conventional coagulation results and outcomes of 183 consecutive patients with confirmed NCP in Tongji hospital were retrospectively analyzed. Results: The overall mortality was 11.5%, the non-survivors revealed significantly higher D-dimer and fibrin degradation product (FDP) levels, longer prothrombin time and activated partial thromboplastin time compared to survivors on admission (P <.05); 71.4% of non-survivors and 0.6% survivors met the criteria of disseminated intravascular coagulation during their hospital stay. Conclusions: The present study shows that abnormal coagulation results, especially markedly elevated D-dimer and FDP are common in deaths with NCP. © 2020 International Society on Thrombosis and Haemostasis",coagulation parameter; D-dimer; disseminated intravascular coagulation; fibrin degradation product; novel coronavirus pneumonia,,"Zhu, N., Zhang, D., Wang, W., China novel coronavirus investigating and research team. A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382 (8), pp. 727-733; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet., 395 (10223), pp. 507-513; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet., 395 (10223), pp. 497-506; Wang, D., Hu, B., Hu, C., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) JAMA, , https://doi.org/10.1001/jama.2020.1585, [published online ahead of print]; Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected: interim guidance, , https://www.who.int/publications-detail/clinical-management-of-severe-acute-respiratory-infection-when-novel-coronavirus-(ncov)-infection-is-suspected, Published January 28, 2020. Accessed January 31, 2020; Taylor, F.B., Jr., Toh, C.H., Hoots, W.K., Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation (2001) Thromb Haemost., 86 (5), pp. 1327-1330; Dempfle, C.E., Wurst, M., Smolinski, M., Use of soluble fibrin antigen instead of D-dimer as fibrin-related marker may enhance the prognostic power of the ISTH overt DIC score (2004) Thromb Haemost., 91 (4), pp. 812-818; Kitchens, C.S., Thrombocytopenia and thrombosis in disseminated intravascular coagulation (DIC) (2009) Educ Program Am Soc Hematol, 2009 (1), pp. 240-246; Gralinski, L.E., Bankhead, A., 3rd, Jeng, S., Mechanisms of severe acute respiratory syndrome coronavirus-induced acute lung injury (2013) mBio., 4 (4), pp. e00271-e313; Berri, F., Rimmelzwaan, G.F., Hanss, M., Plasminogen controls inflammation and pathogenesis of influenza virus infections via fibrinolysis (2013) PLoS Pathog., 9 (3)","Sun, Z.; Department of Clinical Laboratory, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyChina; email: 499388475@qq.com",,Blackwell Publishing Ltd,15387933,,JTHOA,32073213,English,J. Thromb. Haemost.,Article,Final,Open Access,Scopus,2-s2.0-85081755873,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Shao N., Zhong M., Yan Y., Pan H., Cheng J., Chen W.",57215876488;55599029500;57201092612;57215872727;55125813900;57139036000;,Dynamic models for Coronavirus Disease 2019 and data analysis,2020,Mathematical Methods in the Applied Sciences,,,,,,,,10.1002/mma.6345,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082190244&doi=10.1002%2fmma.6345&partnerID=40&md5=d0579c28716f1a542e0b55f7a2e52c0f,"School of Mathematical Sciences, Fudan University, Shanghai, China; School of Mathematics, Southeast University, Nanjing, China; School of Mathematics, Shanghai University of Finance and Economics, Shanghai, China; Shanghai Key Laboratory for Contemporary Applied Mathematics, Fudan University, Shanghai, China","Shao, N., School of Mathematical Sciences, Fudan University, Shanghai, China; Zhong, M., School of Mathematics, Southeast University, Nanjing, China; Yan, Y., School of Mathematics, Shanghai University of Finance and Economics, Shanghai, China; Pan, H., School of Mathematical Sciences, Fudan University, Shanghai, China; Cheng, J., School of Mathematical Sciences, Fudan University, Shanghai, China, Shanghai Key Laboratory for Contemporary Applied Mathematics, Fudan University, Shanghai, China; Chen, W., School of Mathematical Sciences, Fudan University, Shanghai, China, Shanghai Key Laboratory for Contemporary Applied Mathematics, Fudan University, Shanghai, China","In this letter, two time delay dynamic models, a Time Delay Dynamical–Novel Coronavirus Pneumonia (TDD-NCP) model and Fudan-Chinese Center for Disease Control and Prevention (CCDC) model, are introduced to track the data of Coronavirus Disease 2019 (COVID-19). The TDD-NCP model was developed recently by Chengąŕs group in Fudan and Shanghai University of Finance and Economics (SUFE). The TDD-NCP model introduced the time delay process into the differential equations to describe the latent period of the epidemic. The Fudan-CDCC model was established when Wenbin Chen suggested to determine the kernel functions in the TDD-NCP model by the public data from CDCC. By the public data of the cumulative confirmed cases in different regions in China and different countries, these models can clearly illustrate that the containment of the epidemic highly depends on early and effective isolations. © 2020 John Wiley & Sons, Ltd.",,Differential equations; Dynamic models; Time delay; Center for disease control and preventions; Coronaviruses; Kernel function; Public data; Time delay process; Disease control,"Chen, Y., Cheng, J., Jiang, Y., Liu, K., (2002) A time delay dynamical model for outbreak of 2019-nCoV and the parameter identification; Yan, Y., Chen, Y., Liu, K., Luo, X., Luo, X., Xu, B., Jiang, Y., Cheng, J., Modeling and prediction for the trend of outbreak of 2019-nCoV based on a time-delay dynamic system (in Chinese) (2020) Sci Sin Math, 50 (3), pp. 1-8. , https://doi.org/10.1360/SSM-2020-0026; Chen, Y., Cheng, J., Jiang, Y., Liu, K., A time delay dynamic system with external source for the local outbreak of 2019-nCoV (2020) Applicable Analysis, , https://doi.org/10.1080/00036811.2020.1732357; Chen, Y., Cheng, J., Jiang, X., Xu, X., (2020) The reconstruction and prediction algorithm of the fractional TDD for the local outbreak of COVID-19; Shao, N., Shao, N., Chen, Y., Cheng, J., Chen, W., (2020) Some novel statistical time delay dynamic model by statistics data from CCDC on Novel Coronavirus Pneumonia submitted to Journal of Control Theory and Applications (in Chinese); Shao, N., Cheng, J., Chen, W., (2020) The reproductive number R0 of COVID-19 based on estimate of a statistical time delay dynamical system, , https://doi.org/10.1101/2020.02.17.20023747; Shao, N., Pan, H., Li, X., CoVID-19 in Japan: What could happen in the future?, , https://doi.org/10.1101/2020.02.21.20026070; Wallinga, J., Lipstch, M., How generation intervals shape the relationship between growth rates and reproductive numbers (1999) Proc R Soc B, 274, pp. 599-604; Wu, J., Leung, K., Leung, G., (2020) Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study, , https://doi.org/10.1016/S0140-6736(20)30260-9, The Lancet;, published online; Read, J.M., Bridgen, J.R., Cummings, D.A., Ho, A., Jewell, C.P., (2020) Novel coronavirus 2019-nCoV: early estimation of epidemiological parameters and epidemic predictions, , https://doi.org/10.1101/2020.01.23.20018549, published online Jan 24; Zhu, Z., Li, J., Gong, D., (2020) Time-varying transmission dynamics of Novel Coronavirus Pneumonia in China[J], , https://doi.org/10.1101/2020.01.25.919787; Zhao, Q., Chen, Y., Small, S., (2020) Analysis of the epidemic growth of the early 2019-nCoV outbreak using internationally confirmed cases., , medRxiv; Xiong, H., Yan, H., (2020) Simulating the infected population and spread trend of 2019-nCov under different policy by EIR model Available at SSRN 3537083; Mizumoto, K., Kagaya, K., Chowell, G., (2020) Early epidemiological assessment of the transmission potential and virulence of 2019 Novel Coronavirus in Wuhan City: China, , medRxiv; Hellewell, J., Abbott, S., Gimma, A., (2020) Feasibility of controlling 2019-nCoV outbreaks by isolation of cases and contacts medRxiv, , https://doi.org/10.1101/2020.02.08.20021162; Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia [J] (2020) N Engl J Med, , https://doi.org/10.1056/NEJMoa2001316","Chen, W.; School of Mathematical Sciences, Fudan UniversityChina; email: wbchen@fudan.edu.cn",,John Wiley and Sons Ltd,1704214,,MMSCD,,English,Math Methods Appl Sci,Letter,Article in Press,Open Access,Scopus,2-s2.0-85082190244,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Tang B., Bragazzi N.L., Li Q., Tang S., Xiao Y., Wu J.",56604580000;56705689300;57215209891;7403436953;7403260550;56962772700;,An updated estimation of the risk of transmission of the novel coronavirus (2019-nCov),2020,Infectious Disease Modelling,5,,,248,255,,4,10.1016/j.idm.2020.02.001,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079396997&doi=10.1016%2fj.idm.2020.02.001&partnerID=40&md5=f283ab69bffd4605bbbfb069074ed340,"The Interdisplinary Research Center for Mathematics and Life Sciences, Xi'an Jiaotong University, Xi'an, 710049, China; Laboratory for Industrial and Applied Mathematics, Department of Mathematics and Statistics, York University, Toronto, Ontario M3J 1P3, Canada; School of Mathematics and Statistics, Xi'an Jiaotong University, Xi'an, 710049, China; School of Mathematics and Information Science, Shaanxi Normal University, Xi'an, 710119, China; Fields-CQAM Laboratory of Mathematics for Public Health, York University, Toronto, Ontario M3J 1P3, Canada","Tang, B., The Interdisplinary Research Center for Mathematics and Life Sciences, Xi'an Jiaotong University, Xi'an, 710049, China, Laboratory for Industrial and Applied Mathematics, Department of Mathematics and Statistics, York University, Toronto, Ontario M3J 1P3, Canada; Bragazzi, N.L., Laboratory for Industrial and Applied Mathematics, Department of Mathematics and Statistics, York University, Toronto, Ontario M3J 1P3, Canada; Li, Q., Laboratory for Industrial and Applied Mathematics, Department of Mathematics and Statistics, York University, Toronto, Ontario M3J 1P3, Canada, School of Mathematics and Statistics, Xi'an Jiaotong University, Xi'an, 710049, China; Tang, S., School of Mathematics and Information Science, Shaanxi Normal University, Xi'an, 710119, China; Xiao, Y., The Interdisplinary Research Center for Mathematics and Life Sciences, Xi'an Jiaotong University, Xi'an, 710049, China, School of Mathematics and Statistics, Xi'an Jiaotong University, Xi'an, 710049, China; Wu, J., The Interdisplinary Research Center for Mathematics and Life Sciences, Xi'an Jiaotong University, Xi'an, 710049, China, Laboratory for Industrial and Applied Mathematics, Department of Mathematics and Statistics, York University, Toronto, Ontario M3J 1P3, Canada, Fields-CQAM Laboratory of Mathematics for Public Health, York University, Toronto, Ontario M3J 1P3, Canada","The basic reproduction number of an infectious agent is the average number of infections one case can generate over the course of the infectious period, in a naïve, uninfected population. It is well-known that the estimation of this number may vary due to several methodological issues, including different assumptions and choice of parameters, utilized models, used datasets and estimation period. With the spreading of the novel coronavirus (2019-nCoV) infection, the reproduction number has been found to vary, reflecting the dynamics of transmission of the coronavirus outbreak as well as the case reporting rate. Due to significant variations in the control strategies, which have been changing over time, and thanks to the introduction of detection technologies that have been rapidly improved, enabling to shorten the time from infection/symptoms onset to diagnosis, leading to faster confirmation of the new coronavirus cases, our previous estimations on the transmission risk of the 2019-nCoV need to be revised. By using time-dependent contact and diagnose rates, we refit our previously proposed dynamics transmission model to the data available until January 29th, 2020 and re-estimated the effective daily reproduction ratio that better quantifies the evolution of the interventions. We estimated when the effective daily reproduction ratio has fallen below 1 and when the epidemics will peak. Our updated findings suggest that the best measure is persistent and strict self-isolation. The epidemics will continue to grow, and can peak soon with the peak time depending highly on the public health interventions practically implemented. © 2020 The Authors",Basic reproduction number; Effective daily reproduction ratio; Emerging and reemerging pathogens; Mathematical modeling; Novel coronavirus,2019 novel coronavirus; Article; basic reproduction number; control strategy; coronavirus disease 2019; disease control; disease transmission; infectious agent; mathematical model; public health; risk factor; RNA virus; virus transmission,"Carlos, W.G., Dela Cruz, C.S., Cao, B., Pasnick, S., Jamil, S., Novel Wuhan (2019-nCoV) coronavirus (2020) American Journal of Respiratory and Critical Care Medicine; Chowell, G., Castillo-Chavez, C., Fenimore, P.W., Kribs-Zaleta, C.M., Arriola, L., Hyman, G.M., Model parameters and outbreak control for SARS (2004) Emerging Infectious Diseases, 10 (7), pp. 1258-1263; Gralinski, L.E., Menachery, V.D., Return of the coronavirus: 2019-nCoV (2020) Viruses, 12 (2); Gumel, A.B., Ruan, S.G., Day, T., Modelling strategies for controlling SARS outbreaks (2004) Proceedings of the Royal Society of London B, 271, pp. 2223-2232; Imai, N., Cori, A., Dorigatti, I., Baguelin, M., Donnelly, C.A., Riley, S., Report 3: Transmissibility of 2019-nCoV (2020), https://www.imperial.ac.uk/media/imperial-college/medicine/sph/ide/gida-fellowships/Imperial-2019-nCoV-transmissibility.pdf, Available at:; Kucharski, A., Russell, T., Diamond, C., CMMID nCoV working group, Funk, S., Eggo, R., Analysis of early transmission of 2019-nCoV and implications for outbreaks in new locations (2020), https://cmmid.github.io/ncov/wuhan_early_dynamics/index.html, Available at:; Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) New England Journal of Medicine; Liu, T., Hu, J., Kang, M., Lin, L., Zhong, H., Xiao, J., Transmission dynamics of 2019 novel coronavirus (2019-nCoV) (2020) bioRxiv; Lu, H., Drug treatment options for the 2019-new coronavirus (2019-nCoV) (2020) Bioscience Trends; Majumder, M., Mandl, K.D., Early transmissibility assessment of a novel coronavirus in Wuhan, China (2020) Social Science Research Network; National Health Commission of the People's Republic of China, (2020), http://www.nhc.gov.cn/, Available at: (Accessed 7 February 2020); Pell, B., Kuang, Y., Viboud, C., Chowell, G., Using phenomenological models for forecasting the 2015 Ebola challenge (2018) Epidemics, 22, pp. 62-70; Read, J.M., Bridgen, J.R., Cummings, D.A., Ho, A., Jewell, C.P., Novel coronavirus 2019-nCoV: Early estimation of epidemiological parameters and epidemic predictions (2020) medRxiv; Riou, J., Althaus, C.L., Pattern of early human-to-human transmission of Wuhan 2019 novel coronavirus (2019-nCoV), December 2019 to January 2020 (2020) Euro Surveillance, 25 (4); Shen, M., Peng, Z., Xiao, Y., Zhang, L., Modelling the epidemic trend of the 2019 novel coronavirus outbreak in China (2020) bioRxiv; Smirnova, A., Chowell, G., A primer on stable parameter estimation and forecasting in epidemiology by a problem-oriented regularized least squares algorithm (2017) Infectious Diseases Modelling, 2, pp. 268-275; Tang, B., Wang, X., Li, Q., Bragazzi, N.L., Tang, S., Xiao, Y., Estimation of the transmission risk of 2019-nCov and its implication for public health interventions (2020) Journal of Clinical Medicine, 9, p. 462; Wu, J.T., Leung, K., Leung, G.M., Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: A modelling study (2020) The Lancet; Yu, X., Updated estimating infected population of Wuhan coronavirus in different policy scenarios by SIR model (2020), http://uni-goettingen.de/en/infectious+diseases/619691.html, Available at:; Zhang, C., Wang, M., MRCA time and epidemic dynamics of the 2019 novel coronavirus (2020) bioRxiv; Zhao, S., Lin, Q., Ran, J., Musa, S.S., Yang, G., Wang, W., Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: A data-driven analysis in the early phase of the outbreak (2020) International Journal of Infectious Diseases","Tang, S.; School of Mathematics and Information Science, Shaanxi Normal UniversityChina; email: sytang@snnu.edu.cn",,KeAi Communications Co.,24680427,,,,English,Infect. Dis. Modelling,Article,Final,Open Access,Scopus,2-s2.0-85079396997,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Baglivo M., Baronio M., Natalini G., Beccari T., Chiurazzi P., Fulcheri E., Petralia P., Michelini S., Fiorentini G., Miggiano G.A., Morresi A., Tonini G., Bertelli M.",57206698148;57211162234;56213221500;57201650651;7004121880;35450538700;52164239800;7003324657;57215841853;7003462789;57215844770;57215641906;15050393400;,Natural small molecules as inhibitors of coronavirus lipid-dependent attachment to host cells: A possible strategy for reducing SARS-COV-2 infectivity?,2020,Acta Biomedica,91,1,,161,164,,,10.23750/abm.v91i1.9402,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082038349&doi=10.23750%2fabm.v91i1.9402&partnerID=40&md5=138968e9bfaddb0ad472b4eec1adc2e1,"MAGI-Euregio, Bolzano, Italy; Department of Anaesthesia and Intensive Care, Fondazione Poliambulanza, Brescia, Italy; Department of Pharmaceutical Sciences, University of Perugia, Via Fabretti 48, Perugia, 06123, Italy; Institute of Genomic Medicine, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Rome, Italy; Pathology Division of Anatomic Pathology, Dept. of Surgical and Diagnostic Sciences (DISC), University of Genova, Italy; UOSD Fetal Pathology and Ginecology IRCCS, Istituto Giannina Gaslini, Genova, Italy; Institute G. Gaslini, Children’s Hospital, Genova, Italy; Department of Vascular Rehabilitation, San Giovanni Battista Hospital, Rome, Italy; Pharmacy Fiorentini, Brescia, Italy; Human Nutrition Research Center, Sacro Cuore Catholic University, Rome, Italy; Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy; Department of Surgery, Fondazione Poliambulanza, Brescia, Italy; EBTNA-Lab, Rovereto, TN, Italy","Baglivo, M., MAGI-Euregio, Bolzano, Italy; Baronio, M., Department of Anaesthesia and Intensive Care, Fondazione Poliambulanza, Brescia, Italy; Natalini, G., Department of Anaesthesia and Intensive Care, Fondazione Poliambulanza, Brescia, Italy; Beccari, T., Department of Pharmaceutical Sciences, University of Perugia, Via Fabretti 48, Perugia, 06123, Italy; Chiurazzi, P., Institute of Genomic Medicine, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Rome, Italy; Fulcheri, E., Pathology Division of Anatomic Pathology, Dept. of Surgical and Diagnostic Sciences (DISC), University of Genova, Italy, UOSD Fetal Pathology and Ginecology IRCCS, Istituto Giannina Gaslini, Genova, Italy; Petralia, P., Institute G. Gaslini, Children’s Hospital, Genova, Italy; Michelini, S., Department of Vascular Rehabilitation, San Giovanni Battista Hospital, Rome, Italy; Fiorentini, G., Pharmacy Fiorentini, Brescia, Italy; Miggiano, G.A., Human Nutrition Research Center, Sacro Cuore Catholic University, Rome, Italy; Morresi, A., Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy; Tonini, G., Department of Surgery, Fondazione Poliambulanza, Brescia, Italy; Bertelli, M., MAGI-Euregio, Bolzano, Italy, EBTNA-Lab, Rovereto, TN, Italy","Background: Viral infectivity depends on interactions between components of the host cell plasma membrane and the virus envelope. Here we review strategies that could help stem the advance of the SARS-COV-2 epidemic. Methods and Results: We focus on the role of lipid structures, such as lipid rafts and cholesterol, involved in the process, mediated by endocytosis, by which viruses attach to and infect cells. Previous studies have shown that many naturally derived substances, such as cyclodextrin and sterols, could reduce the infectivity of many types of viruses, including the coronavirus family, through interference with lipid-dependent attachment to human host cells. Conclusions: Certain molecules prove able to reduce the infectivity of some coronaviruses, possibly by inhibiting viral lipid-dependent attachment to host cells. More research into these molecules and methods would be worthwhile as it could provide insights the mechanism of transmission of SARS-COV-2 and, into how they could become a basis for new antiviral strategies. © Mattioli 1885.",Cholesterol; Coronavirus; Lipid raft; Phytosterol; SARS-COV-2,"angiotensin converting enzyme 2; betulic acid; caveolin; clathrin; dynamin; hopanoid; methyl beta cyclodextrin; sitosterol; virus fusion inhibitor; virus spike protein; antivirus agent; COVID-19; lipid; severe acute respiratory syndrome coronavirus 2; antiviral activity; Article; cell membrane; cellular distribution; coronavirus disease 2019; endocytosis; fatty acid metabolism; hepatitis B; host cell; Human immunodeficiency virus infection; lipid raft; nonhuman; protein expression; Severe acute respiratory syndrome coronavirus 2; virus attachment; virus entry; virus envelope; virus infectivity; animal; Betacoronavirus; chemistry; Coronavirus infection; drug effect; human; molecular library; pharmacology; physiology; virus attachment; virus pneumonia; Animals; Antiviral Agents; Betacoronavirus; Coronavirus Infections; Humans; Lipids; Pneumonia, Viral; Small Molecule Libraries; Virus Attachment","Yan, R., Yan, R., Zhang, Y., (2020) Structural Basis for the Recognition of the Sars-Cov-2 By, 2762, pp. 1-10; Zhou, P., Yang, X., Wang, X., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature, p. 579; Corman, V.M., Landt, O., Kaiser, M., (2019) Detection of 2019 Novel Coronavirus (2019-Ncov) By, pp. 1-8; Kannan, S., Ali, P.S.S., Sheeza, A., Hemalatha, K., (2020) COVID-19 (Novel Coronavirus 2019) – Recent Trends, 19, pp. 2006-2011; Heaton, N.S., Randall, G., Multifaceted roles for lipids in viral infection (2011) Trends Microbiol, 19 (7), pp. 368-375; Lajoie, P., Nabi, I.R., (2007) Regulation of Raft-Dependent Endocytosis, 11 (4), pp. 644-653; Tang, Q., Liu, P., Chen, M., (2019) Virion-Associated Cholesterol Regulates the Infection of Human Parainfluenza Virus Type 3; Glende, J., Schwegmann-Wessels, C., Al-Falah, M., Importance of cholesterol-rich membrane microdomains in the interaction of the S protein of SARS-coronavirus with the cellular receptor angiotensin-converting enzyme 2 (2008) Virology, 381 (2), pp. 215-221; Wei, X., She, G., Wu, T., Xue, C., Cao, Y., PEDV enters cells through clathrin -, caveolae -, and lipid raft - Mediated endocytosis and traffics via the endo -/ lysosome pathway (2020) Vet Res, pp. 1-18; Thorp, E.B., Gallagher, T.M., Requirements for Ceacams and Cholesterol during Murine Coronavirus Cell Entry, (29); Choi, K.S., Aizaki, H., Lai, M.M.C., (2011) Murine Coronavirus Requires Lipid Rafts for Virus Entry and Cell-Cell Fusion but Not for Virus Release, 79 (15), pp. 9862-9871; Cervin, M., Anderson, R., (1991) Modulation of Coronavirus-Me-Diated Cell Fusion by Homeostatic Control of Cholesterol and Fatty Acid Metabolism, 149, pp. 142-149; Daya, M., Anderson, R., (1999) Cholesterol Enhances Mouse Hepatitis Virus-Mediated Cell Fusion., 283 (1988), pp. 276-283; Li, G., Li, Y., Yamate, M., (2007) Lipid Rafts Play an Important Role in the Early Stage of Severe Acute Respiratory Syndrome-Corona-Virus Life Cycle, 9, pp. 96-102; Guo, H., Huang, M., Yuan, Q., (2017) The Important Role of Lipid Raft-Mediated Attachment in the Infection of Cultured Cells by Coronavirus Infectious Bronchitis Virus Beaudette Strain, 12 (1); Cagno, V., Tintori, C., Civra, A., Novel Broad Spectrum Virucidal Molecules against Enveloped Viruses, 2018, pp. 1-18; Cagno, V., Andreozzi, P., Alicarnasso, M.D., (2017) With a Virucidal Inhibition Mechanism, pp. 1-10; Zidovetzki, R., Levitan, I., Use of cyclodextrins to manipulate plasma membrane cholesterol content: Evidence, misconceptions and control strategies (2007) Biochim Biophys Acta, 1768 (6), pp. 1311-1324; Fenyvesi, V.A., An, J.S., Csabai, K., Malanga, M., Szente, L., (2014) Me-Thyl-Beta-Cyclodextrins: The Role of Number and Types of Substituents in Solubilizing Power, pp. 1443-1452; Verma, S.P., (2009) HIV: A Raft-Targeting Approach for Prevention and Therapy Using Plant-Derived Compounds (Review, 2, pp. 51-59; Gujjeti, R.P., Anti-HIV Activity of Phytosterol Isolated from Aerva lanata Roots (2017) Pharmacogn J, 9 (1), pp. 112-116; Parvez, M.K., Rehman, T., Alam, P., Al-Dosari, M.S., Alqasoumi, S.I., Alajmi, M.F., Plant-derived antiviral drugs as novel hepatitis B virus inhibitors: Cell culture and molecular docking study (2019) Saudi Pharm J, 27 (3), pp. 389-400; Sigler, K., (2009) Sterols and Triterpenoids with Antiviral Activity, , (June 2015; Abumweis, S.S., Barake, R., Jones, P.J.H., (2008) Randomized Controlled Trials, 1, pp. 1-17; Proc, M.C., Stanols, P., Nutrition, H., Wash-F, Unilever N V, Foods F (2003) Management of Blood Cholesterol Levels, 78, pp. 965-978. , (August); Gironi, B., Oliva, R., Petraccone, L., BBA-Biomem-branes Solvation properties of raft-like model membranes (2019) Bba-Biomembr, 1861 (11); Pollock, S., Branza, N., Böhmer, A., Radulescu, C., Dwek, R.A., Polyunsaturated liposomes are antiviral against hepatitis B and C viruses and HIV by decreasing cholesterol levels in infected cells (2010) Proc Natl Acad Sci U S A, 107 (40), pp. 17176-17181. , Oct 5; Oliva, A.F., Risco, C., (2018) Targeting Host Lipid Flows: Exploring New Antiviral and Antibiotic Strategies. 2019, pp. 1-17. , December","Baglivo, M.; MAGI Euregio, Via Maso della Pieve, 60/A, Italy; email: mirko.baglivo@assomagi.org",,Mattioli 1885,3924203,,ATPRA,32191676,English,Acta Biomed.,Article,Final,,Scopus,2-s2.0-85082038349,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Xia J., Tong J., Liu M., Shen Y., Guo D.",57215820045;8299096200;57215816136;36969881200;57192713334;,Evaluation of coronavirus in tears and conjunctival secretions of patients with SARS-CoV-2 infection,2020,Journal of Medical Virology,,,,,,,6,10.1002/jmv.25725,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081720938&doi=10.1002%2fjmv.25725&partnerID=40&md5=f48cf7a455c35dcc986d0a771a389f6e,"Department of Ophthalmology, Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou, Zhejiang, China","Xia, J., Department of Ophthalmology, Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou, Zhejiang, China; Tong, J., Department of Ophthalmology, Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou, Zhejiang, China; Liu, M., Department of Ophthalmology, Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou, Zhejiang, China; Shen, Y., Department of Ophthalmology, Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou, Zhejiang, China; Guo, D., Department of Ophthalmology, Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou, Zhejiang, China","Objective: This study aimed to assess the presence of novel coronavirus in tears and conjunctival secretions of SARS–CoV-2-infected patients. Methods: A prospective interventional case series study was performed, and 30 confirmed novel coronavirus pneumonia (NCP) patients were selected at the First Affiliated Hospital of Zhejiang University from 26 January 2020 to 9 February 2020. At an interval of 2 to 3 days, tear and conjunctival secretions were collected twice with disposable sampling swabs for reverse-transcription polymerase chain reaction (RT-PCR) assay. Results: Twenty-one common-type and nine severe-type NCP patients were enrolled. Two samples of tear and conjunctival secretions were obtained from the only one patient with conjunctivitis yielded positive RT-PCR results. Fifty-eight samples from other patents were all negative. Conclusion: We speculate that SARS-CoV-2 may be detected in the tears and conjunctival secretions in NCP patients with conjunctivitis. © 2020 Wiley Periodicals, Inc.",coronavirus; horizontal transmission; infection,,"Lu, H., Stratton, C.W., Tang, Y.W., Outbreak of pneumonia of unknown etiology In Wuhan, China: the mystery and the miracle (2020) J Med Virol, 92, pp. 401-402. , https://doi.org/10.1002/jmv.25678; Zhang, L., Shen, F.M., Chen, F., Lin, Z., Origin and evolution of the 2019 novel coronavirus (2020) Clin Infect Dis, , https://doi.org/10.1093/cid/ciaa112; (2020) Novel coronavirus (2019-nCoV) situation report—3 (23 January 2020), , https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200123-sitrep-3-2019-ncov.pdf?sfvrsn=d6d23643_8, Geneva, Switzerland, World Health Organization; (2020) Statement on the Second Meeting of the International Health Regulations (2005) Emergency Committee regarding the outbreak of novel coronavirus (2019-nCoV), , https://www.who.int/news-room/detail/30-01-2020-statement-on-the-second-meeting-of-the-international-health-regulations, Geneva, Switzerland, World Health Organization; (2020) Novel Coronavirus (2019-nCoV) Situation Report—29 (18 February 2020), , https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200218-sitrep-29-covid-19.pdf?sfvrsn=6262de9e_2, Geneva, Switzerland, World Health Organization; Enserink, M., Update: ‘A bit chaotic.’ Christening of new coronavirus and its disease name create confusion (2020) sciencemag, , https://www.sciencemag.org/news/2020/02/bit-chaotic-christening-new-coronavirus-and-its-disease-name-create-confusion; Office of State Administration of Traditional Chinese Medicine (2020) Notice on the Issuance of a Programme for the Diagnosis and Treatment of Novel Coronavirus (2019-Ncov) Infected Pneumonia (Trial 4Th Ed.), , https://bgs.satcm.gov.cn/zhengcewenjian/2020-01-28/12576.html, In Chinese, Accessed January 18, 2020; Loon, S.-C., Teoh, S.C.B., Oon, L.L.E., The severe acute respiratory syndrome coronavirus in tears (2004) Br J Ophthalmol, 88 (7), pp. 861-863. , https://doi.org/10.1136/bjo.2003.035931; Chan, J.F.-W., Kok, K.-H., Zhu, Z., Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan (2020) Emerg Microbes Infect, 9 (1), pp. 221-236. , https://doi.org/10.1080/22221751.2020.1719902; Dai, X., Beijing News, , http://www.bjnews.com.cn/news/2020/01/23/678189.html, Peking University Hospital Wang Guangfa disclosed treatment status on Weibo and suspected infection without wearing goggles, 24 January 2020, Accessed January 23, 2020; Lu, C.W., Liu, X.F., Jia, Z.F., 2019-nCoV transmission through the ocular surface must not be ignored (2020) Lancet, 395. , https://doi.org/10.1016/S0140-6736(20)30313-5; (2020) Office of State Administration of Traditional Chinese Medicine, , https://bgs.satcm.gov.cn/zhengcewenjian/2020-02-06/12848.html, Notice on the issuance of a programme for the diagnosis and treatment of novel coronavirus (2019-nCoV) infected pneumonia (trial 5th ed.) (In Chinese), Accessed February 6, 2020; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395 (10223), pp. 497-506. , https://doi.org/10.1016/S0140-6736(20)30183-5; Schwartz, D.A., Graham, A.L., Potential maternal and infant outcomes from (Wuhan) coronavirus 2019-nCoV infecting pregnant women: lessons from SARS, MERS, and other human coronavirus infections (2020) Viruses, 12 (2). , https://doi.org/10.3390/v12020194; Lian, K.Y., Napper, G., Stapleton, F.J., Kiely, P.M., Infection control guidelines for optometrists 2016 (2017) Clin Exp Optom, 100 (4), pp. 341-356. , https://doi.org/10.1111/cxo.12544; Corman, V.M., Landt, O., Kaiser, M., Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR (2020) Euro Surveill, 25 (3). , https://doi.org/10.2807/1560-7917.ES.2020.25.3.2000045; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395 (10223), pp. 507-513. , https://doi.org/10.1016/S0140-6736(20)30211-7; Lin, C., Ye, R., Xia, Y.L., A meta-analysis to evaluate the effectiveness of real-time PCR for diagnosing novel coronavirus infections (2015) Genet Mol Res, 14 (4), pp. 15634-15641. , https://doi.org/10.4238/2015; Chan, W.M., Yuen, K.S., Fan, D.S., Lam, D.S., Chan, P.K., Sung, J.J., Tears and conjunctival scrapings for coronavirus in patients with SARS (2004) Br J Ophthalmol, 88 (7), pp. 968-969. , https://doi.org/10.1136/bjo.2003.039461","Shen, Y.; Department of Ophthalmology, Zhejiang University School of Medicine First Affiliated HospitalChina; email: idrshen@zju.edu.cn",,John Wiley and Sons Inc.,1466615,,JMVID,32100876,English,J. Med. Virol.,Article,Article in Press,Open Access,Scopus,2-s2.0-85081720938,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Shen K., Yang Y., Wang T., Zhao D., Jiang Y., Jin R., Zheng Y., Xu B., Xie Z., Lin L., Shang Y., Lu X., Shu S., Bai Y., Deng J., Lu M., Ye L., Wang X., Wang Y., Gao L., China National Clinical Research Center for Respiratory Diseases, National Center for Children's Health, Beijing, China, Group of Respirology, Chinese Pediatric Society, Chinese Medical Association, Chinese Medical Doctor Association Committee on Respirology Pediatrics, China Medicine Education Association Committee on Pediatrics, Chinese Research Hospital Association Committee on Pediatrics, Chinese Non-government Medical Institutions Association Committee on Pediatrics, China Association of Traditional Chinese Medicine, Committee on Children's Health and Medicine Research, China News of Drug Information Association, Committee on Children's Safety Medication, Global Pediatric Pulmonology Alliance",55641765700;35274110900;55709760700;56643549700;57214896164;23970463800;55498102300;55475549100;57214894557;57215932008;57214899455;57214895563;8730817700;57209304436;11839358600;57214897400;8926026100;55736858000;57200054201;55448946300;,"Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts’ consensus statement",2020,World Journal of Pediatrics,,,,,,,6,10.1007/s12519-020-00343-7,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079468616&doi=10.1007%2fs12519-020-00343-7&partnerID=40&md5=c301eff962cbe3090fe23f5b6e9df3b4,"Department of Respiratory Medicine, Beijing Children’s Hospital, Capital Medical University, Beijing, China; Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, Beijing, China; Center of Hematologic Oncology, Beijing Children’s Hospital, Capital Medical University, Beijing, China; Department of Pediatrics, Zhongnan Hospital of Wuhan University, Wuhan, China; Department of Pediatrics, Renmin Hospital of Wuhan University, Wuhan, China; Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Respiratory Medicine, Shenzhen Children’s Hospital, Shenzhen, China; Hospital Management Institute of Wuhan University, Zhongnan Hospital of Wuhan University, Wuhan, China; Department of Pediatric Respiratory, Shengjing Hospital of China Medical University, Shenyang, China; Department of Respiratory Medicine, Wuhan Children’s Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Infectious Disease, Shenzhen Children’s Hospital, Shenzhen, China; Department of Respiratory Medicine, Children’s Hospital of Shanghai, Shanghai, China; Department of Pediatrics, Peking University First Hospital, Beijing, China; Department of Pediatrics, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China; Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China","Shen, K., Department of Respiratory Medicine, Beijing Children’s Hospital, Capital Medical University, Beijing, China; Yang, Y., Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, Beijing, China; Wang, T., Center of Hematologic Oncology, Beijing Children’s Hospital, Capital Medical University, Beijing, China; Zhao, D., Department of Pediatrics, Zhongnan Hospital of Wuhan University, Wuhan, China; Jiang, Y., Department of Pediatrics, Renmin Hospital of Wuhan University, Wuhan, China; Jin, R., Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Zheng, Y., Department of Respiratory Medicine, Shenzhen Children’s Hospital, Shenzhen, China; Xu, B., Department of Respiratory Medicine, Beijing Children’s Hospital, Capital Medical University, Beijing, China; Xie, Z., Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, Beijing, China; Lin, L., Hospital Management Institute of Wuhan University, Zhongnan Hospital of Wuhan University, Wuhan, China; Shang, Y., Department of Pediatric Respiratory, Shengjing Hospital of China Medical University, Shenyang, China; Lu, X., Department of Respiratory Medicine, Wuhan Children’s Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Shu, S., Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Bai, Y., Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Deng, J., Department of Infectious Disease, Shenzhen Children’s Hospital, Shenzhen, China; Lu, M., Department of Respiratory Medicine, Children’s Hospital of Shanghai, Shanghai, China; Ye, L., Department of Pediatrics, Peking University First Hospital, Beijing, China; Wang, X., Department of Pediatrics, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China; Wang, Y., Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China; Gao, L., Department of Respiratory Medicine, Beijing Children’s Hospital, Capital Medical University, Beijing, China; China National Clinical Research Center for Respiratory Diseases; National Center for Children's Health, Beijing, China; Group of Respirology, Chinese Pediatric Society, Chinese Medical Association; Chinese Medical Doctor Association Committee on Respirology Pediatrics; China Medicine Education Association Committee on Pediatrics; Chinese Research Hospital Association Committee on Pediatrics; Chinese Non-government Medical Institutions Association Committee on Pediatrics; China Association of Traditional Chinese Medicine, Committee on Children's Health and Medicine Research; China News of Drug Information Association, Committee on Children's Safety Medication; Global Pediatric Pulmonology Alliance","Since the outbreak of 2019 novel coronavirus infection (2019-nCoV) in Wuhan City, China, by January 30, 2020, a total of 9692 confirmed cases and 15,238 suspected cases have been reported around 31 provinces or cities in China. Among the confirmed cases, 1527 were severe cases, 171 had recovered and been discharged at home, and 213 died. And among these cases, a total of 28 children aged from 1 month to 17 years have been reported in China. For standardizing prevention and management of 2019-nCoV infections in children, we called up an experts’ committee to formulate this experts’ consensus statement. This statement is based on the Novel Coronavirus Infection Pneumonia Diagnosis and Treatment Standards (the fourth edition) (National Health Committee) and other previous diagnosis and treatment strategies for pediatric virus infections. The present consensus statement summarizes current strategies on diagnosis, treatment, and prevention of 2019-nCoV infection in children. © 2020, Children's Hospital, Zhejiang University School of Medicine.",,,"National Health Commission of People’s Republic of China, , https://www.nhc.gov.cn/xcs/yqfkdt/202001/a53e6df293cc4ff0b5a16ddf7b6b2b31.shtml, Access 20 Jan 2020; Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med.; (2020) Diagnosis and Treatment of Pneumonia Caused by Novel Coronavirus (Trial Version 4), , https://www.nhc.gov.cn/xcs/zhengcwj/202001/4294563ed35b43209b31739bd0785e67/files/7a9309111267475a99d4306962c8bf78.pdf, Access 28 Jan; Suggestions on the diagnosis and treatment of novel coronavirus infection in children in Hubei province (trial version 1) (2020) CJCP., 22, pp. 96-99. , (in Chinese; Chan, J.F., Yuan, S., Kok, K.H., Wang, K.K., Chu, H., Yang, J., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person to-person transmission: a study of a family cluster (2020) Lancet; Huang, C.L., Wang, Y.M., Li, X.W., Ren, L.L., Zhao, J.P., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan China (2020) Lancet; Chen, N.S., Zhou, M., Dong, X., Qu, J.M., Gong, F.Y., Han, Y., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet; Li, Z.Z., Shen, K.L., Wei, X.M., Wang, H.L., Lu, J., Tian, H., Clinical analysis of pediatric SARS cases in Beijing (2003) Chin J Pediatr, 41, pp. 574-577. , (in Chinese; Yang, Y.H., Concern for severe acute respiratory syndrom (2003) Chin J Pediatr, 41, pp. 401-402. , (in Chinese; Zeng, Q.Y., Liu, L., Zeng, H.S., Yu, M.H., Ye, Q.C., Deng, L., Clinical characteristics and prognosis of 33 children with severe acute respiratory syndrome in Guangzhou area (2003) Chin J Pediatr, 41, p. 408. , (in Chinese; Thabet, F., Chehab, M., Bafaqih, H., Al, M.S., Middle East respiratory syndrome coronavirus in children (2015) Saudi Med J, 36, pp. 484-486; (2019) Code for the Diagnosis and Treatment of Community-Acquired Pneumonia in Children, , https://www.nhc.gov.cn/yzygj/s7653/201902/bfa758ad6add48a599bc74b588a6e89a.shtml, edition, Access 11 Feb 2019; Guidelines for management of community acquired pneumonia in children (2013) Chin J Pediatr., 51, pp. 145-152. , (in Chinese; Harris, M., Clark, J., Coote, N., Fletcher, P., Harnden, A., McKean, M., British Thoracic Society guidelines for the management of community acquired pneumonia in children: update 2011 (2011) Thorax, 66, pp. 1-23; Bradley, J.S., Byington, C.L., Shah, S.S., Alverson, B., Carter, E.R., Harrison, C., The management of community-acquired pneumonia in infants and children older than 3 months of age: clinical practice guidelines by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America (2011) Clin Infect Dis, 53, pp. e25-e76; Wang, B.X., Fish, E.N., Global virus outbreaks: interferons as 1st responders (2019) Semin Immunol, 43, p. 101300; Al-Tawfiq, J.A., Momattin, H., Dib, J., Memish, Z.A., Ribavirin and interferon therapy in patients infected with the Middle East respiratory syndrome coronavirus: an observational study (2014) Int J Infect Dis, 20, pp. 42-46. , COI: 1:CAS:528:DC%2BC2cXhtlGmsLg%3D; Wang, H.Q., Ma, L.L., Jiang, J.D., Pang, R., Chen, Y.J., Li, Y.H., Recombinant human interferon alpha 2b broad-spectrum anti-respiratory viruses pharmacodynamics study in vitro (2014) Acta Pharmaceu Sin, 49, pp. 1547-1553. , COI: 1:CAS:528:DC%2BC2MXhtlemsb7M, (in Chinese; Hijano, D.R., Siefker, D.T., Shrestha, B., Jaligama, S., Type I interferon potentiates IgA immunity to respiratory syncytial virus infection during infancy (2018) Sci Rep, 8, p. 11034; Shen, K.L., Shang, Y.X., Zhang, G.C., Xu, B.P., Fu, Z., Cao, L., Expert consensus on rational application of interferon α in pediatrics (2018) Chin J Appl Clin Pediatr, 33, pp. 1301-1308. , (in Chinese; Guidelines for rational drug use in children with wheezing disorders (2018) Chin J Appl Clin Pediatr., 33, pp. 1460-1472. , (in Chinese; Liu, B., Shang, Y.X., Lu, Y.D., Study on the safety of recombinant human interferon 2b injection (pseudomonas) and hydroxyethyl starch 40 as excipient in SD rats (2019) Int J Pediatr, 46, pp. 692-697. , (in Chinese; (2018) Guidelines on the diagnosis and treatment of hand, foot and mouth disease, , https://www.nhc.gov.cn/yzygj/s3594q/201805/5db274d8697a41ea84e88eedd8bf8f63.shtml, Access 28 Jun 2018; Xu, Y.L., Li, Y., Chen, Y.P., Xin, S.X., Xie, L., Liang, Y.D., A multicenter controlled clinical study on the efficacy and safety of recombinant human interferon α2b spray in the treatment of hand, foot and mouth disease in children (2018) Chin J Infect, 36, pp. 101-106. , (in Chinese; Expert consensus on diagnosis and treatment of herpetic pharyngitis (2019 edition) (2019) Chin J Pediatr., 57, pp. 177-180. , (in Chinese; Shen, K.L., Shang, Y.X., Zhang, H., A multicenter, randomized, controlled clinical study on the efficacy and safety of recombinant human interferon 2b spray (pseudomonas) in the treatment of acute upper respiratory tract infection in children (2019) Chin J Appl Clin Pediatr, 34, pp. 1010-1016. , (in Chinese; Gao, H., Zhang, L.L., Wei, Q., Duan, Z.J., Tu, X.M., Yu, Z.A., Preventive and therapeutic effects of recombinant IFN -α2b nasal spray on SARS-CoV infection in Macaca mulata (2005) Chin J Exp Clin Virol, 19, pp. 207-211. , COI: 1:CAS:528:DC%2BD28XhsFCns7w%3D, (in Chinese; Yu, D.X., Chen, Q., Zhang, L.L., Liu, Y., Yu, Z.A., Li, Z.F., A field trial of recombinant human interferon α-2b for nasal spray to prevent SARS and other respiratory viral infections (2005) Chin J Exp Clin Virol, 19, pp. 216-219. , COI: 1:CAS:528:DC%2BD28XhsFCns70%3D, (in Chinese; Chu, C.M., Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings (2004) Thorax, 59, pp. 252-256. , COI: 1:STN:280:DC%2BD2c%2Fps1anuw%3D%3D; Lopinar Veletonavir Tablet Specification, , https://www.jianke.com/product/79823.html, Access 7 July 2017; Ji, X.G., Zhao, Y.H., Zhang, M., Zhao, J.H., Wang, J.Y., The Experimental Study of the Anti-SARS-CoV Effect of Arbidole (2004) Pharm J Chin PLA, 20, pp. 274-276. , (in Chinese; (2019) Influenza Diagnosis and Treatment Protocol (Revised Edition 2019), , https://wenku.baidu.com/view/00f0d41d2079168884868762caaedd3383c4b57f.html, Access 30 Nov; Home care for patients with suspected novel coronavirus (NCoV) infection presenting with mild symptoms and management of contacts, , https://www.who.int/internal-publications-detail/home-care-for-patients-with-suspected-novel-coronavirus-(nCoV)-infection-presenting-with-mild-symptoms-and-management-of-contacts, Access 20 Jan 2020; (2019) Novel Coronavirus (2019-nCoV) from Spreading to Others in Homes and Communities, , https://www.cdc.gov/coronavirus/2019-ncov/guidance-prevent-spread-chinese.html, Access 20 Jan 2020; (2020) Guidelines for Transmission and Prevention of Novel Coronaviruses, , https://www.nhc.gov.cn/xcs/kpzs/202001/9e73060017d744aeafff8834fc0389f4.shtml, Access 27 Jan","Shen, K.; Department of Respiratory Medicine, Beijing Children’s Hospital, Capital Medical UniversityChina; email: kunlingshen1717@163.com",,Institute of Pediatrics of Zhejiang University,17088569,,,32034659,English,World J. Pediatr.,Review,Article in Press,Open Access,Scopus,2-s2.0-85079468616,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Qu R., Ling Y., Zhang Y.-H.-Z., Wei L.-Y., Chen X., Li X.-M., Liu X.-Y., Liu H.-M., Guo Z., Ren H., Wang Q.",57052317200;55183430800;57215905343;57215900279;57215903477;57215905678;57215903597;57215902777;24279665000;55087381900;57199479189;,Platelet-to-lymphocyte ratio is associated with prognosis in patients with coronavirus disease-19,2020,Journal of Medical Virology,,,,,,,,10.1002/jmv.25767,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082322413&doi=10.1002%2fjmv.25767&partnerID=40&md5=a3143341fa0d315025befb0471cc9a4f,"Department of Critical Care Medicine, Huizhou Municipal Central Hospital, Huizhou, China; Department of Hematology and Oncology, National Cancer Center/National Clinical Research Cancer for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China; Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Medical, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China; Institute of Infection, Immunology and Tumor Microenvironment, Medical College, Wuhan University of Science and Technology, Wuhan, China","Qu, R., Department of Critical Care Medicine, Huizhou Municipal Central Hospital, Huizhou, China; Ling, Y., Department of Critical Care Medicine, Huizhou Municipal Central Hospital, Huizhou, China; Zhang, Y.-H.-Z., Department of Hematology and Oncology, National Cancer Center/National Clinical Research Cancer for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China; Wei, L.-Y., Department of Hematology and Oncology, National Cancer Center/National Clinical Research Cancer for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China; Chen, X., Department of Hematology and Oncology, National Cancer Center/National Clinical Research Cancer for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China; Li, X.-M., Department of Hematology and Oncology, National Cancer Center/National Clinical Research Cancer for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China; Liu, X.-Y., Department of Hematology and Oncology, National Cancer Center/National Clinical Research Cancer for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China; Liu, H.-M., Department of Critical Care Medicine, Huizhou Municipal Central Hospital, Huizhou, China; Guo, Z., Department of Hematology and Oncology, National Cancer Center/National Clinical Research Cancer for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China, Institute of Infection, Immunology and Tumor Microenvironment, Medical College, Wuhan University of Science and Technology, Wuhan, China; Ren, H., Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, Department of Medical, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China; Wang, Q., Institute of Infection, Immunology and Tumor Microenvironment, Medical College, Wuhan University of Science and Technology, Wuhan, China","Abstract: Since December 2019, novel coronavirus infected pneumonia emerged in Wuhan city and rapidly spread throughout China. In severe novel coronavirus pneumonia cases, the number of platelets, their dynamic changes during the treatment, platelet-to-lymphocyte ratio (PLR) were a concern. We sought to describe the platelet feature of these cases. Single-center case series of the 30 hospitalized patients with confirmed coronavirus disease (COVID)-19 in Huizhou municipal central hospital from January 2020 to February 2020 were retrospectively analyzed. Demographic, clinical, blood routine results, other laboratory results, and treatment data were collected and analyzed. Outcomes of severe patients and nonsevere patients were compared. Univariate analysis showed that: age, platelet peaks, and PLR at peak platelet were the influencing factors in severe patients, multivariate analysis showed that the PLR value at peak platelet during treatment was an independent influencing factor in severe patients. The average hospitalization day of patients with platelet peaks during treatment was longer than those without platelet peaks (P <.05). The average age of patients with platelet peaks during treatment was older than those without platelet peaks (P <.05). The patients with significantly elevated platelets during treatment had longer average hospitalization days. And the higher PLR of patients during treatment had longer average hospitalization days. Single-center case series of the 30 hospitalized patients with confirmed COVID-19 in Huizhou Municipal Central Hospital, presumed that the number of platelets and their dynamic changes during the treatment may have a suggestion on the severity and prognosis of the disease. The patient with markedly elevated platelets and longer average hospitalization days may be related to the cytokine storm. The PLR of patients means the degree of cytokine storm, which might provide a new indicator in the monitoring in patients with COVID-19. © 2020 Wiley Periodicals, Inc.",coronavirus disease; cytokine storm; platelet value; platelet-to-lymphocyte ratio; risk factor,,"Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382 (8), pp. 727-773; Zhang, M.Q., Wang, X.H., Chen, Y.L., Clinical features of 2019 novel coronavirus pneumonia in the early stage from a fever clinic in Beijing (2020) Zhonghua Jie He He Hu Xi Za Zhi, 43; Li, H., Wang, Y.M., Xu, J.Y., Cao, B., Potential antiviral therapeutics for 2019 novel coronavirus (2020) Zhonghua Jie He He Hu Xi Za Zhi, 43; Mattiuzzi, C., Lippi, G., Which lessons shall we learn from the 2019 novel coronavirus outbreak? 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Behrens, K., Alexander, W.S., Alexander, W.S., Cytokine control of megakaryopoiesis (2018) Growth Factors, 36 (3-4), pp. 89-103; Wang, D., Hu, B., Hu, C., Clinical characteristics of 138 hospitalized patients With 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) JAMA, (e201585). , https://doi.org/10.1001/jama.2020.1585; Rousanusan, T.A., Aldoss, I.T., Cowley, B.D., Jr., Recurrent acute thrombocytopenia in the hospitalized patient: sepsis, DIC, HIT, or antibiotic-induced thrombocytopenia (2010) Am J Hematol, 85 (1), pp. 71-74; Eickmann, M., Gravemann, U., Handke, W., Inactivation of three emerging viruses severe acute respiratory syndrome coronavirus, Crimean-Congo haemorrhagic fever virus and Nipah virus - in platelet concentrates by ultraviolet C light and in plasma by methylene blue plus visible light (2020) Vox Sang, , https://doi.org/10.1111/vox.12888; Poon, T.C.W., Pang, R.T.K., Chan, K.C.A., Proteomic analysis reveals platelet factor 4 and beta-thromboglobulin as prognostic markers in severe acute respiratory syndrome (2012) Electrophoresis, 33 (12); Pilaczyńska-Cemel, M., Gołda, R., Dąbrowska, A., Przybylski, G., Analysis of the level of selected parameters of inflammation,circulating immune complexes,and related indicators (neutrophil/lymphocyte, platelet/lymphocyte, CRP/CIC) in patients with obstructive diseases (2019) Cent Eur J Immunol, 44 (3), pp. 292-298; Shinya, K., Gao, Y., Cilloniz, C., Integrated clinical, pathologic, virologic, and transcriptomic analysis of H5N1 influenza virus-induced viral pneumonia in the rhesus macaque (2012) J Virol, 86 (11), pp. 6055-6066; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan,China[J] (2020) Lancet, 395 (10223), pp. 497-506; Ramana, C.V., DeBerge, M.P., Kumar, A., Alia, C.S., Durbin, J.E., Enelow, R.I., Inflammatory impact of IFN-γ in CD8+T cellmediated lung injury is mediated by both Stat1-dependent and-independent pathways (2015) Am J Physiol Lung Cell Mol Physiol, 308 (7), pp. L650-L657; Liu, Y., Gayle, A.A., Wilder-Smith, A., Rocklöv, J., The reproductive number of COVID-19 is higher compared to SARS coronavirus (2020) J Travel Med, 27. , https://doi.org/10.1093/jtm/taaa021; Peiris, J., Hui, K.P., Yen, H.L., Host response to influenza virus: protection versus immunopathology (2010) Curr Opin Immunol, 22 (4), pp. 475-481; Liang, W., Guan, W., Chen, R., Cancer patients in SARS-CoV-2 infection:a nationwide analysis in China (2020) Lancet Oncol, 21, pp. 335-337. , https://doi.org/10.1016/S1470-2045(20)30096-6; Kudo, K., Takasaki, J., Manabe, T., Systemic corticosteroids and early administration of antiviral agents for pneumonia with acute wheezing due to influenza A(H1N1)pdm09 in Japan (2012) PLoS One, 7 (2); Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med, , https://doi.org/10.1056/NEJMoa2001316; Rayes, J., Bourne, J.H., Brill, A., Watson, S.P., The dual role of platelet-innate immune cell interactions in thrombo-inflammation (2019) Res Pract Thromb Haemost, 4 (1), pp. 23-35; Sun, M.L., Yang, J.M., Sun, Y.P., Inhibitors of RAS might be a good choice for the therapy of COVID-19 pneumonia (2020) Zhonghua Jie He He Hu Xi Za Zhi, 43. , https://doi.org/10.3760/cma.j.issn.1001-0939.2020.0014; Malik, Y.S., Sircar, S., Bhat, S., Emerging novel Coronavirus (2019-nCoV)-current scenario, evolutionary perspective based on genome analysis and recent developments (2020) Vet Q, 40, pp. 68-76. , https://doi.org/10.1080/01652176.2020.1727993; Liu, J., Zheng, X., Tong, Q., Overlapping and discrete aspects of the pathology and pathogenesis of the emerging human pathogenic coronaviruses SARS-CoV, MERS-CoV, and 2019-nCoV (2020) J Med Virol, 92, pp. 491-494. , https://doi.org/10.1002/jmv.25709","Guo, Z.; Department of Hematology and Oncology, National Cancer Center/National Clinical Research Cancer for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeChina; email: guozhi77@126.com",,John Wiley and Sons Inc.,1466615,,JMVID,32181903,English,J. Med. Virol.,Article,Article in Press,Open Access,Scopus,2-s2.0-85082322413,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Meng L., Hua F., Bian Z.",57212949883;55802511400;7103314705;,Coronavirus Disease 2019 (COVID-19): Emerging and Future Challenges for Dental and Oral Medicine,2020,Journal of Dental Research,,,,,,,1,10.1177/0022034520914246,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081951781&doi=10.1177%2f0022034520914246&partnerID=40&md5=9b8e942752f5eec4f1681b003cbef73f,"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST), Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China; Center for Evidence-Based Stomatology, School and Hospital of Stomatology, Wuhan University, Wuhan, China","Meng, L., The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST), Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China; Hua, F., Center for Evidence-Based Stomatology, School and Hospital of Stomatology, Wuhan University, Wuhan, China; Bian, Z., The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST), Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China","The epidemic of coronavirus disease 2019 (COVID-19), originating in Wuhan, China, has become a major public health challenge for not only China but also countries around the world. The World Health Organization announced that the outbreaks of the novel coronavirus have constituted a public health emergency of international concern. As of February 26, 2020, COVID-19 has been recognized in 34 countries, with a total of 80,239 laboratory-confirmed cases and 2,700 deaths. Infection control measures are necessary to prevent the virus from further spreading and to help control the epidemic situation. Due to the characteristics of dental settings, the risk of cross infection can be high between patients and dental practitioners. For dental practices and hospitals in areas that are (potentially) affected with COVID-19, strict and effective infection control protocols are urgently needed. This article, based on our experience and relevant guidelines and research, introduces essential knowledge about COVID-19 and nosocomial infection in dental settings and provides recommended management protocols for dental practitioners and students in (potentially) affected areas. © International & American Associations for Dental Research 2020.",dental education; dental practice management; dental public health; infection control; transmission; virology,,"Andersson, L., Andreasen, J.O., Day, P., Heithersay, G., Trope, M., DiAngelis, A.J., Kenny, D.J., Flores, M.T., International Association of Dental Traumatology guidelines for the management of traumatic dental injuries: 2. 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Dent. Res.,Article,Article in Press,Open Access,Scopus,2-s2.0-85081951781,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Corman V.M., Landt O., Kaiser M., Molenkamp R., Meijer A., Chu D.K., Bleicker T., Brünink S., Schneider J., Schmidt M.L., Mulders D.G., Haagmans B.L., van der Veer B., van den Brink S., Wijsman L., Goderski G., Romette J.-L., Ellis J., Zambon M., Peiris M., Goossens H., Reusken C., Koopmans M.P., Drosten C.",34876424800;7003613718;57215949421;6603227562;57061899200;57203970681;55376985300;37060341300;57212594806;57215123725;57212447073;6701371301;22836811200;57201195834;57201195771;57201195378;7003305080;7402714456;7006818684;7005486823;7101668890;6602366009;7006736989;7003813990;,Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR,2020,Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin,25,3,,,,,34,10.2807/1560-7917.ES.2020.25.3.2000045,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078687750&doi=10.2807%2f1560-7917.ES.2020.25.3.2000045&partnerID=40&md5=57b65d3def631178a03267ac830007a5,"Charité - Universitätsmedizin Berlin Institute of Virology, Germany and German Centre for Infection Research (DZIF)Berlin, Germany; Tib-MolbiolBerlin, Germany; Department of Viroscience, Erasmus MC, Rotterdam, Netherlands; National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands; University of Hong Kong, Hong Kong, China; Universite d Aix-Marseille, Marseille, France; Public Health England, London, United Kingdom; Department of Medical Microbiology, Vaccine and Infectious Diseases Institute, University of Antwerp, Antwerp, Belgium","Corman, V.M., Charité - Universitätsmedizin Berlin Institute of Virology, Germany and German Centre for Infection Research (DZIF)Berlin, Germany; Landt, O., Tib-MolbiolBerlin, Germany; Kaiser, M., Tib-MolbiolBerlin, Germany; Molenkamp, R., Department of Viroscience, Erasmus MC, Rotterdam, Netherlands; Meijer, A., National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands; Chu, D.K., University of Hong Kong, Hong Kong, China; Bleicker, T., Charité - Universitätsmedizin Berlin Institute of Virology, Germany and German Centre for Infection Research (DZIF)Berlin, Germany; Brünink, S., Charité - Universitätsmedizin Berlin Institute of Virology, Germany and German Centre for Infection Research (DZIF)Berlin, Germany; Schneider, J., Charité - Universitätsmedizin Berlin Institute of Virology, Germany and German Centre for Infection Research (DZIF)Berlin, Germany; Schmidt, M.L., Charité - Universitätsmedizin Berlin Institute of Virology, Germany and German Centre for Infection Research (DZIF)Berlin, Germany; Mulders, D.G., Department of Viroscience, Erasmus MC, Rotterdam, Netherlands; Haagmans, B.L., Department of Viroscience, Erasmus MC, Rotterdam, Netherlands; van der Veer, B., National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands; van den Brink, S., National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands; Wijsman, L., National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands; Goderski, G., National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands; Romette, J.-L., Universite d Aix-Marseille, Marseille, France; Ellis, J., Public Health England, London, United Kingdom; Zambon, M., Public Health England, London, United Kingdom; Peiris, M., University of Hong Kong, Hong Kong, China; Goossens, H., Department of Medical Microbiology, Vaccine and Infectious Diseases Institute, University of Antwerp, Antwerp, Belgium; Reusken, C., National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands; Koopmans, M.P., Department of Viroscience, Erasmus MC, Rotterdam, Netherlands; Drosten, C., Charité - Universitätsmedizin Berlin Institute of Virology, Germany and German Centre for Infection Research (DZIF)Berlin, Germany","BackgroundThe ongoing outbreak of the recently emerged novel coronavirus (2019-nCoV) poses a challenge for public health laboratories as virus isolates are unavailable while there is growing evidence that the outbreak is more widespread than initially thought, and international spread through travellers does already occur.AimWe aimed to develop and deploy robust diagnostic methodology for use in public health laboratory settings without having virus material available.MethodsHere we present a validated diagnostic workflow for 2019-nCoV, its design relying on close genetic relatedness of 2019-nCoV with SARS coronavirus, making use of synthetic nucleic acid technology.ResultsThe workflow reliably detects 2019-nCoV, and further discriminates 2019-nCoV from SARS-CoV. Through coordination between academic and public laboratories, we confirmed assay exclusivity based on 297 original clinical specimens containing a full spectrum of human respiratory viruses. Control material is made available through European Virus Archive - Global (EVAg), a European Union infrastructure project.ConclusionThe present study demonstrates the enormous response capacity achieved through coordination of academic and public laboratories in national and European research networks.",2019-nCoV; diagnostics; laboratory; novel coronavirus; outbreak; RT-PCR; testing; Wuhan,"virus RNA; classification; Coronavirinae; Coronavirus infection; epidemic; genetics; human; isolation and purification; laboratory technique; procedures; real time polymerase chain reaction; sensitivity and specificity; virology; Clinical Laboratory Techniques; Coronavirus; Coronavirus Infections; Disease Outbreaks; Humans; Real-Time Polymerase Chain Reaction; RNA, Viral; Sensitivity and Specificity",,,,NLM (Medline),15607917,,,31992387,English,Euro Surveill.,Article,Final,Open Access,Scopus,2-s2.0-85078687750,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Kim H.,57207824165;,Outbreak of novel coronavirus (COVID-19): What is the role of radiologists?,2020,European Radiology,,,,,,,,10.1007/s00330-020-06748-2,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079802097&doi=10.1007%2fs00330-020-06748-2&partnerID=40&md5=a3c3c9975e428ac01e99bf95a1627f97,"Department of Radiology, Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, Seoul, 03080, South Korea","Kim, H., Department of Radiology, Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, Seoul, 03080, South Korea","• Novel coronavirus (COVID-19)-infected pneumonia usually manifests as bilateral ground-glass opacities in the lung periphery on chest CT scans. • Role of radiologists includes not only early detection of lung abnormality, but also suggestion of disease severity, potential progression to acute respiratory distress syndrome, and possible bacterial co-infection in hospitalized patients. © 2020, European Society of Radiology.",,,"(2020) Coronavirus COVID-19 Global Cases, , https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6, Available via, Accessed 11 Feb 2020; Wu, J.T., Leung, K., Leung, G.M., Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: A modelling study (2020) Lancet, , https://doi.org/10.1016/S0140-6736(20)30260-9; Zhao, S., Lin, Q., Ran, J., Musa, S.S., Yang, G., Wang, W., Lou, Y., Wang, M.H., Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: A data-driven analysis in the early phase of the outbreak (2020) International Journal of Infectious Diseases, 92, pp. 214-217; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Cao, B., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) The Lancet, 395 (10223), pp. 497-506; Wang, D., Hu, B., Hu, C., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) JAMA; Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Zhang, L., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) The Lancet, 395 (10223), pp. 507-513; Munster, V.J., Koopmans, M., van Doremalen, N., van Riel, D., de Wit, E., A novel coronavirus emerging in China - key questions for impact assessment (2020) N Engl J Med; Song, F., Shi, N., Shan, F., Emerging coronavirus 2019-nCoV pneumonia (2020) Radiology, , https://doi.org/10.1148/radiol.2020200274:200274; Chung, M., Bernheim, A., Mei, X., CT imaging features of 2019 novel coronavirus (2019-nCoV) (2020) Radiology, , https://doi.org/10.1148/radiol.2020200230:200230; Ooi, G.C., Khong, P.L., Muller, N.L., Severe acute respiratory syndrome: temporal lung changes at thin-section CT in 30 patients (2004) Radiology, 230, pp. 836-844; Pan, Y., Guan, H., Zhou, S., Initial CT findings and temporal changes in patients with the novel coronavirus pneumonia (2019-nCoV): a study of 63 patients in Wuhan, China (2020) Eur Radiol; Pan, Y., Guan, H., Imaging changes in patients with 2019-nCov (2020) Eur Radiol; Chan, J.F.-W., Yuan, S., Kok, K.-H., To, K.K.-W., Chu, H., Yang, J., Xing, F., Yuen, K.-Y., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) The Lancet, 395 (10223), pp. 514-523; MacIntyre, C.R., Chughtai, A.A., Barnes, M., The role of pneumonia and secondary bacterial infection in fatal and serious outcomes of pandemic influenza a(H1N1)pdm09 (2018) BMC Infect Dis, 18, p. 637","Kim, H.; Department of Radiology, Seoul National University Hospital, 101, Daehak-ro, Jongno-gu, South Korea; email: khj.snuh@gmail.com",,Springer,9387994,,EURAE,32072255,English,Eur. Radiol.,Editorial,Article in Press,Open Access,Scopus,2-s2.0-85079802097,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhang L., Lin D., Kusov Y., Nian Y., Ma Q., Wang J., Von Brunn A., Leyssen P., Lanko K., Neyts J., De Wilde A., Snijder E.J., Liu H., Hilgenfeld R.",57190290343;57215221720;7004085684;56377424100;55226537700;55883668000;6701437402;6602458061;57193420997;57203013377;24474438300;7006058325;56070556500;7006843618;,"α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment",2020,Journal of Medicinal Chemistry,,,,,,,,10.1021/acs.jmedchem.9b01828,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080134059&doi=10.1021%2facs.jmedchem.9b01828&partnerID=40&md5=2ef2325dcec93c472195f054c1efe1bb,"Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Lübeck, 23562, Germany; German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems Site, University of Lübeck, Lübeck, 23562, Germany; Shanghai Institute of Materia Medica, Shanghai, 201203, China; Max von Pettenkofer Institute, Ludwig-Maximilians-University Munich, Munich, 80336, Germany; Rega Institute for Medical Research, University of Leuven, Leuven, 3000, Belgium; Leiden University Medical Center, Leiden, 2333 ZA, Netherlands","Zhang, L., Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Lübeck, 23562, Germany, German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems Site, University of Lübeck, Lübeck, 23562, Germany; Lin, D., Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Lübeck, 23562, Germany, German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems Site, University of Lübeck, Lübeck, 23562, Germany, Shanghai Institute of Materia Medica, Shanghai, 201203, China; Kusov, Y., Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Lübeck, 23562, Germany; Nian, Y., Shanghai Institute of Materia Medica, Shanghai, 201203, China; Ma, Q., Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Lübeck, 23562, Germany; Wang, J., Shanghai Institute of Materia Medica, Shanghai, 201203, China; Von Brunn, A., Max von Pettenkofer Institute, Ludwig-Maximilians-University Munich, Munich, 80336, Germany; Leyssen, P., Rega Institute for Medical Research, University of Leuven, Leuven, 3000, Belgium; Lanko, K., Rega Institute for Medical Research, University of Leuven, Leuven, 3000, Belgium; Neyts, J., Rega Institute for Medical Research, University of Leuven, Leuven, 3000, Belgium; De Wilde, A., Leiden University Medical Center, Leiden, 2333 ZA, Netherlands; Snijder, E.J., Leiden University Medical Center, Leiden, 2333 ZA, Netherlands; Liu, H., Shanghai Institute of Materia Medica, Shanghai, 201203, China; Hilgenfeld, R., Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Lübeck, 23562, Germany, German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems Site, University of Lübeck, Lübeck, 23562, Germany, Shanghai Institute of Materia Medica, Shanghai, 201203, China","The main protease of coronaviruses and the 3C protease of enteroviruses share a similar active-site architecture and a unique requirement for glutamine in the P1 position of the substrate. Because of their unique specificity and essential role in viral polyprotein processing, these proteases are suitable targets for the development of antiviral drugs. In order to obtain near-equipotent, broad-spectrum antivirals against alphacoronaviruses, betacoronaviruses, and enteroviruses, we pursued a structure-based design of peptidomimetic α-ketoamides as inhibitors of main and 3C proteases. Six crystal structures of protease-inhibitor complexes were determined as part of this study. Compounds synthesized were tested against the recombinant proteases as well as in viral replicons and virus-infected cell cultures; most of them were not cell-toxic. Optimization of the P2 substituent of the α-ketoamides proved crucial for achieving near-equipotency against the three virus genera. The best near-equipotent inhibitors, 11u (P2 = cyclopentylmethyl) and 11r (P2 = cyclohexylmethyl), display low-micromolar EC50 values against enteroviruses, alphacoronaviruses, and betacoronaviruses in cell cultures. In Huh7 cells, 11r exhibits three-digit picomolar activity against the Middle East Respiratory Syndrome coronavirus. © 2020 American Chemical Society.",,,"Hilgenfeld, R., Peiris, M., From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses (2013) Antiviral Res., 100, pp. 286-295; Zaki, A.M., Van Boheemen, S., Bestebroer, T.M., Osterhaus, A.D., Fouchier, R.A., Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia (2012) N. Engl. J. Med., 367, pp. 1814-1820; Eckerle, I., Muller, M.A., Kallies, S., Gotthardt, D.N., Drosten, C., In-vitro renal epithelial cell infection reveals a viral kidney tropism as a potential mechanism for acute renal failure during Middle East Respiratory Syndrome (MERS) Coronavirus infection (2013) Virol. 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Virol., 80, pp. 5927-5940; De Wilde, A.H., Jochmans, D., Posthuma, C.C., Zevenhoven-Dobbe, J.C., Van Nieuwkoop, S., Bestebroer, T.M., Van Den Hoogen, B.G., Snijder, E.J., Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture (2014) Antimicrob. Agents Chemother., 58, pp. 4875-4884; Chan, J.F., Choi, G.K., Tsang, A.K., Tee, K.M., Lam, H.Y., Yip, C.C., To, K.K., Yuen, K.Y., Development and evaluation of novel real-time reverse transcription-PCR assays with locked nucleic acid probes targeting leader sequences of human-pathogenic coronaviruses (2015) J. Clin. 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Chem.,Article,Article in Press,Open Access,Scopus,2-s2.0-85080134059,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Columbus C., Brust K.B., Arroliga A.C.",57205641973;55566690000;35398839700;,2019 novel coronavirus: an emerging global threat,2020,Baylor University Medical Center Proceedings,,,,,,,,10.1080/08998280.2020.1731272,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080049428&doi=10.1080%2f08998280.2020.1731272&partnerID=40&md5=df14c463c9f9408c426b202f0b5406cf,"Division of Infectious Diseases, Department of Internal Medicine, Baylor University Medical Center, Dallas, TX, United States; Division of Infectious Diseases, Department of Internal Medicine, Baylor Scott & White Medical Center–Temple, Temple, TX, United States; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Baylor Scott & White Medical Center–Temple, Temple, TX, United States","Columbus, C., Division of Infectious Diseases, Department of Internal Medicine, Baylor University Medical Center, Dallas, TX, United States; Brust, K.B., Division of Infectious Diseases, Department of Internal Medicine, Baylor Scott & White Medical Center–Temple, Temple, TX, United States; Arroliga, A.C., Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Baylor Scott & White Medical Center–Temple, Temple, TX, United States","The coronavirus (CoV) epidemic that began in China in December 2019 follows earlier epidemics of severe acute respiratory syndrome CoV in China and Middle East respiratory syndrome CoV in Saudi Arabia. The full genome of the 2019 novel coronavirus (2019-nCoV) has now been shared, and data have been gathered from several case series. As of February 11, 2020, there have been 45,182 laboratory-confirmed cases, the vast majority in China, with 1115 deaths, for an overall case-fatality rate of 2.5%. Cases have been confirmed in 27 countries. On average, each patient infects 2.2 other people. Symptomatic infection appears to predominantly affect adults, with a 5-day estimated incubation period between infection and symptom onset. The most common presenting symptoms are fever, cough, dyspnea, and myalgias and/or fatigue. All cases reported to date have shown radiographic evidence of pneumonia. 2019-nCoV is diagnosed by real-time reverse transcriptase polymerase chain reaction. Treatment is largely supportive, with regimens including antiviral therapy. Corticosteroids are not routinely recommended. Hand hygiene, prompt identification and isolation of suspect patients, and appropriate use of personal protective equipment are the most reliable methods to contain the epidemic. © 2020, © 2020 Baylor University Medical Center.",2019-nCoV; coronavirus; Covid-19; epidemic; infectious diseases,,"https://www.cdc.gov/sars/about/fs-sars.html, SARS Basics Fact Sheet,. Last updated December 6, 2017; (2019), https://www.who.int/emergencies/mers-cov/en/, Middle East respiratory syndrome coronavirus (MERS-CoV): MERS monthly summary, November,. 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First case of 2019 novel coronavirus in the United States (2020) N Engl J Med, , Jan 31 [Epub ahead of print]; (2020), https://www.cdc.gov/coronavirus/2019-ncov/hcp/clinical-guidance-management-patients.html, Interim Clinical Guidance for Management of Patients with Confirmed 2019 Novel Coronavirus (2019-nCoV) Infection.,. Updated February 12, 2020. Accessed February 13; (2020), https://www.cdc.gov/coronavirus/2019-nCoV/hcp/clinical-criteria.html, Evaluating and Reporting Persons Under Investigation (PUI).,. Updated February 12, 2020. Accessed February 13; (2020), https://www.cdc.gov/coronavirus/2019-nCoV/hcp/infection-control.html, Interim Infection Prevention and Control Recommendations for Patients with Confirmed 2019 Novel Coronavirus (2019-nCoV) or Persons Under Investigation for 2019-nCoV Healthcare Settings,. Updated February 12, 2020. Accessed February 13","Columbus, C.; Division of Infectious Diseases, Department of Internal Medicine, Baylor University Medical Center at Dallas, 3500 Gaston Avenue, United States; email: cristie.columbus@bswhealth.org",,Taylor and Francis Inc.,8998280,,,,English,Baylor Univ. Med. Cent. Proc.,Review,Article in Press,,Scopus,2-s2.0-85080049428,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Yang Y., Peng F., Wang R., Guan K., Jiang T., Xu G., Sun J., Chang C.",57215606620;57215610564;57215601162;57215596675;7402148439;10340314600;57204502218;37049890600;,The deadly coronaviruses: The 2003 SARS pandemic and the 2020 novel coronavirus epidemic in China,2020,Journal of Autoimmunity,,,102434,,,,,10.1016/j.jaut.2020.102434,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081332789&doi=10.1016%2fj.jaut.2020.102434&partnerID=40&md5=822f4f95353d66bef7cfd07a8a71f264,"Department of Allergy & Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, National Clinical Research Center for Immunologic Diseases, Beijing, 100730, China; Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China; Suzhou Institute of Systems Medicine, Suzhou, Jiangsu 215123, China; Department of Respiratory Diseases, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, 100853, China; Department of Infection Prevention and Disease Control, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, 100853, China; Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, DavisCA 95616, United States; Division of Pediatric Immunology and Allergy, Joe DiMaggio Children's Hospital, Hollywood, FL, United States","Yang, Y., Department of Allergy & Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, National Clinical Research Center for Immunologic Diseases, Beijing, 100730, China; Peng, F., Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China, Suzhou Institute of Systems Medicine, Suzhou, Jiangsu 215123, China; Wang, R., Department of Respiratory Diseases, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, 100853, China; Guan, K., Department of Allergy & Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, National Clinical Research Center for Immunologic Diseases, Beijing, 100730, China; Jiang, T., Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China, Suzhou Institute of Systems Medicine, Suzhou, Jiangsu 215123, China; Xu, G., Department of Infection Prevention and Disease Control, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, 100853, China; Sun, J., Department of Allergy & Clinical Immunology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, National Clinical Research Center for Immunologic Diseases, Beijing, 100730, China; Chang, C., Division of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, DavisCA 95616, United States, Division of Pediatric Immunology and Allergy, Joe DiMaggio Children's Hospital, Hollywood, FL, United States","The 2019-nCoV is officially called SARS-CoV-2 and is the cause of the disease named COVID-19. This viral epidemic in China has led to the deaths of over 1800 people, mostly elderly or those with an underlying chronic disease or immunosuppressed state. This is the third serious Coronavirus outbreak in less than 20 years, following SARS in 2002–2003 and MERS in 2012. While human strains of Coronavirus are associated with about 15% of cases of the common cold, the SARS-CoV-2 may present with varying degrees of severity, from flu-like symptoms to death. It is currently believed that this deadly Coronavirus strain originated from wild animals at the Huanan market in Wuhan, a city in Hubei province. Bats, snakes and pangolins have been cited as potential carriers based on the sequence homology of CoV isolated from these animals and the viral nucleic acids of the virus isolated from SARS-CoV-2 infected patients. Extreme quarantine measures, including sealing off large cities, closing borders and confining people to their homes, were instituted in January 2020 to prevent spread of the virus, but by that time much of the damage had been done, as human-human transmission became evident. While these quarantine measures are necessary and have prevented a historical disaster along the lines of the Spanish flu, earlier recognition and earlier implementation of quarantine measures may have been even more effective. Lessons learned from SARS resulted in faster determination of the nucleic acid sequence and a more robust quarantine strategy. However, it is clear that finding an effective antiviral and developing a vaccine are still significant challenges. The costs of the epidemic are not limited to medical aspects, as the virus has led to significant sociological, psychological and economic effects globally. Unfortunately, emergence of SARS-CoV-2 has led to numerous reports of Asians being subjected to racist behavior and hate crimes across the world. © 2020 Elsevier Ltd",Bats; Coronavirus; Epidemic; Epidemiology; Flu; Human to human transmission; Pandemic; Pneumonia; Pyroptosis; SARS-CoV; SARS-CoV-2,,"Weiss, S.R., Leibowitz, J.L., Coronavirus pathogenesis (2011) Adv. Virus Res., 81, pp. 85-164; Balasuriya, U.B.R., List of contributors (2017) Fenner's Veterinary Virology, pp. xvii-xviii. , N.J. MacLachlan E.J. Dubovi fifth ed. Academic Press Boston; Su, S., Epidemiology, genetic recombination, and pathogenesis of coronaviruses (2016) Trends Microbiol., 24 (6), pp. 490-502; Zhu, N., A novel coronavirus from patients with pneumonia in China, 2019 (2020), N Engl J Med; Isaacs, D., Epidemiology of coronavirus respiratory infections (1983) Arch. Dis. Child., 58 (7), pp. 500-503; Greenberg, S.B., Update on human rhinovirus and coronavirus infections (2016) Semin. Respir. Crit. 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Clinical trial of antiviral drug remdesivir starts in Wuhan. (in Chinese) Available from:; Liu, X., Wang, X.-J., Potential Inhibitors for 2019-nCoV Coronavirus M Protease from Clinically Approved Medicines (2020), bioRxiv 2020.01.29.924100; Richardson, P., Baricitinib as potential treatment for 2019-nCoV acute respiratory disease (2020) Lancet, 395 (10223), pp. e30-e31. , Epub 2020 Feb 4; Lu, H., Drug treatment options for the 2019-new coronavirus (2019-nCoV) (2020) Biosci. Trends; Wang, M., Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro (2020), Cell research; Daily, C., First antiviral drug approved to fight coronavirus (2020), http://global.chinadaily.com.cn/a/202002/17/WS5e49efc2a310128217277fa3.html, Feb.17,2002] Available from:; Ji, S., Unique synergistic antiviral effects of Shufeng Jiedu Capsule and oseltamivir in influenza A viral-induced acute exacerbation of chronic obstructive pulmonary disease (2020) Biomed. Pharmacotherapy = Biomed. Pharmacotherapie, 121. , 109652-109652; Ding, Y., The Chinese prescription lianhuaqingwen capsule exerts anti-influenza activity through the inhibition of viral propagation and impacts immune function (2017) BMC Compl. Alternative Med., 17 (1). , 130-130; Guiding Principles for the Intervention of Acute Psychological Crisis in Pneumonia Cases with New Coronavirus Infection. (In Chinese) (2020), http://www.nhc.gov.cn/xcs/zhengcwj/202001/6adc08b966594253b2b791be5c3b9467.shtml, China National Health Commission Beijing Available from:; Zumla, A., Coronaviruses - drug discovery and therapeutic options (2016) Nat. Rev. Drug Discov., 15 (5), pp. 327-347","Chang, C.; University of California, Davis, 451 Health Sciences Drive, Suite 6510, United States; email: chrchang@ucdavis.edu",,Academic Press,8968411,,JOAUE,,English,J. Autoimmun.,Review,Article in Press,Open Access,Scopus,2-s2.0-85081332789,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Michaels M.G., La Hoz R.M., Danziger-Isakov L., Blumberg E.A., Kumar D., Green M., Pruett T.L., Wolfe C.R.",7005166995;54682044500;8329743600;7006810026;7402293996;7406237201;7006843339;35799088400;,Coronavirus disease 2019: Implications of emerging infections for transplantation,2020,American Journal of Transplantation,,,,,,,,10.1111/ajt.15832,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081932342&doi=10.1111%2fajt.15832&partnerID=40&md5=a1121b0a8084f9f5f2c2e678ca848508,"Department of Pediatrics, Division of Pediatric Infectious Diseases, University of Pittsburgh School of Medicine, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, PA, United States; Division of Infectious Disease and Geographic Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States; Department of Pediatrics, Division of Infectious Diseases, Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, United States; Department of Internal Medicine, Division of Infectious Disease, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States; Infectious Diseases and Multi-Organ Transplant, University Health Network, University of Toronto, Toronto, ON, Canada; Department of Surgery, Division of Transplantation, University of Minnesota, Minneapolis, MN, United States; Division of Infectious Diseases, Duke University Medical Center, Durham, NC, United States","Michaels, M.G., Department of Pediatrics, Division of Pediatric Infectious Diseases, University of Pittsburgh School of Medicine, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, PA, United States; La Hoz, R.M., Division of Infectious Disease and Geographic Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States; Danziger-Isakov, L., Department of Pediatrics, Division of Infectious Diseases, Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, United States; Blumberg, E.A., Department of Internal Medicine, Division of Infectious Disease, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States; Kumar, D., Infectious Diseases and Multi-Organ Transplant, University Health Network, University of Toronto, Toronto, ON, Canada; Green, M., Department of Pediatrics, Division of Pediatric Infectious Diseases, University of Pittsburgh School of Medicine, UPMC Children’s Hospital of Pittsburgh, Pittsburgh, PA, United States; Pruett, T.L., Department of Surgery, Division of Transplantation, University of Minnesota, Minneapolis, MN, United States; Wolfe, C.R., Division of Infectious Diseases, Duke University Medical Center, Durham, NC, United States","The recent identification of an outbreak of 2019- novel Coronavirus is currently evolving, and the impact on transplantation is unknown. However, it is imperative that we anticipate the potential impact on the transplant community in order to avert severe consequences of this infection on both the transplant community and contacts of transplant patients. © 2020 The American Society of Transplantation and the American Society of Transplant Surgeons",donors and donation; editorial/personal viewpoint; infection and infectious agents—viral; infectious disease; preventive health care,,"(2020) Disease outbreak news: Novel Coronavirus – Republic of Korea (ex-China), , https://www.who.int/csr/don/21-january-2020-novel-coronavirus-republic-of-korea-ex-china/en, January 21,, Accessed February 8, 2020; Zhu, N.A., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382 (8), pp. 727-733; Li, Q., Guan, X., Wu, P., Transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med, , https://doi.org/10.1056/NEJMoa2001316; Novel coronavirus (2019-nCoV), , https://www.who.int/emergencies/diseases/novel-coronavirus-2019, Accessed February 15, 2020; 2019 novel coronavirus (2019-nCoV), , https://www.cdc.gov/coronavirus/2019-ncov/index.html, Accessed February 15, 2020; Chan, J.-W., Yuan, S., Kok, K.-H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person -to-person transmission: a study of a family cluster (2020) Lancet, 395 (10223), pp. 514-523; Wang, D., Hu, B.O., Hu, C., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus infected pneumonia in Wuhan, China (2020) JAMA, , https://doi.org/10.1001/jama.2020.1585; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395 (10223), pp. 507-513; Kumar, D., Tellier, R., Draker, R., Levy, G., Humar, A., Severe acute respiratory syndrome (SARS) in the liver transplant recipient and guidelines for donor SARS screening (2003) Am J Transplant, 3, pp. 977-981; AlGhamdi, M., Mushtaq, F., Awn, N., Shalhoub, S., MERS CoV infection in two renal transplant recipients: case report (2015) Am J Transplant, 15, pp. 1101-1104; Battegay, M., Kuehl, R., Tschudin-Sutter, S., Hirsch, H.H., Widmer, A.F., Neher, R.A., 2019–novel Coronavirus (2019–nCoV): estimated the case fatality rate–a word of caution (2020) Swiss Medical Weekly, 150, p. w20203; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395 (10223), pp. 497-506; Holshue, M.L., DeBolt, C., Lindquist, S., First case of novel 2019 coronavirus in the United States (2020) N Engl J Med, , https://doi.org/10.1056/NEJMoa2001191; Important information for blood establishments regarding the novel coronavirus outbreak, , https://www.fda.gov/vaccines-blood-biologics/safety-availability-biologics/important-information-blood-establishments-regarding-novel-coronavirus-outbreak, Accessed February 15, 2020; Red Cross media statement on 2019 novel coronavirus, , https://www.redcross.org/about-us/news-and-events/press-release/2020/red-cross-media-statement-on-2019-novel-coronavirus.html, Accessed February 16, 2020; Cluster of pneumonia cases caused by a novel coronavirus, Wuhan, China 17 January 2020, , https://www.ecdc.europa.eu/sites/default/files/documents/Risk%20assessment%20-%20pneumonia%20Wuhan%20China%2017%20Jan%202020.pdf, Accessed February 16, 2020; Anesi, J.A., Silveira, F.P., Arenaviruses and West Nile virus in solid organ transplant recipients: guidelines from the American Society of transplantation infectious diseases community of practice (2019) Clin Transplant, 33 (9); An update and guidance on 2019 novel coronavirus (2019-nCov) pretransplant ID clinicians: Updated 27 January 2020, , https://tts.org/23-tid/tid-news/657-tid-update-and-guidance-on-2019-novel-coronavirus-2019-ncov-for-transplant-id, Accessed February 16, 2020; Information for transplant programs and OPOs regarding 2019 novel Coronavirus, , https://optn.transplant.hrsa.gov/news/information-for-transplant-programs-and-opos-regarding-2019-novel-coronavirus/, Accessed February 9, 2020","Michaels, M.G.; Department of Pediatrics, Division of Pediatric Infectious Diseases, University of Pittsburgh School of Medicine, UPMC Children’s Hospital of PittsburghUnited States; email: michmg@upmc.edu",,Blackwell Publishing Ltd,16006135,,AJTMB,32090448,English,Am. J. Transplant.,Article,Article in Press,Open Access,Scopus,2-s2.0-85081932342,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Brüssow H.,7007100339;,The Novel Coronavirus – A Snapshot of Current Knowledge,2020,Microbial Biotechnology,13,3,,607,612,,,10.1111/1751-7915.13557,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081638445&doi=10.1111%2f1751-7915.13557&partnerID=40&md5=5f8d9202402910f8f1073d5debd08280,"Department of Biosystems, Group of Gene Technology, KU Leuven, Leuven, Belgium","Brüssow, H., Department of Biosystems, Group of Gene Technology, KU Leuven, Leuven, Belgium","Another animal to human transmission of a coronavirus occurred in December 2019 on a live animal market in the Chinese city of Wuhan causing an epidemic in China, reaching now different continents. This minireview summarizes the research literature on the virological, clinical and epidemiological aspects of this epidemic published until end of February 2020. © 2020 The Authors. Microbial Biotechnology published by John Wiley & Sons Ltd and Society for Applied Microbiology.",,,"Backer, J.A., Klinkenberg, D., Wallinga, J., Incubation period of 2019 novel coronavirus (2019-nCoV) infections among travellers from Wuhan, January 2020 (2020) Euro Surveill, 25, pp. 20-28; Chan, J.F., Yuan, S., Kok, K.H., To, K.K., Chu, H., Yang, J., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, 395, pp. 514-523; Chang, D., Lin, M., Wei, L., Xie, L., Zhu, G., Dela Cruz, C.S., Sharma, L., Epidemiologic and clinical characteristics of novel coronavirus infections involving 13 patients Outside Wuhan, China (2020) JAMA, , https://doi.org/10.1001/jama.2020.1623, [Epub ahead of print]; Chang, D., Xu, H., Rebaza, A., Sharma, L., Dela Cruz, C.S., Protecting health-care workers from subclinical coronavirus infection (2020) Lancet Respir Med, , [Epub ahead of print]; Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395, pp. 507-513; Danchin, A., Ng, P.T.W., Turicini, G., (2020) A new transmission route for the propagation of the SARS-CoV-2 coronavirus, , https://doi.org/10.1101/2020.02.14.20022939, medRxiv preprint; Gilbert, M., Pullano, G., Pinotti, F., Valdano, E., Poletto, C., Boëlle, P.Y., Preparedness and vulnerability of African countries against importations of COVID-19: a modelling study (2020) Lancet, , [Epub ahead of print]; Haider, N., Yavlinsky, A., Simons, D., Osman, A.Y., Ntoumi, F., Zumla, A., Kock, R., Passengers' destinations from China: low risk of Novel Coronavirus (2019-nCoV) transmission into Africa and South America (2020) Epidemiol Infect, 148; Holshue, M.L., DeBolt, C., Lindquist, S., Lofy, K.H., Wiesman, J., Bruce, H., First Case of 2019 Novel Coronavirus in the United States (2020) N Engl J Med, , https://doi.org/10.1056/NEJMoa2001191, [Epub ahead of print]; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506; Jiang, S., Shi, Z., Shu, Y., Song, J., Gao, G.F., Tan, W., Guo, D., A distinct name is needed for the new coronavirus (2020) Lancet, , [Epub ahead of print]; Lai, S., Bogoch, I., Ruktanonchai, N., Watts, A., Li, Y., Yu, J., Assessing spread risk of Wuhan novel coronavirus within and beyond China, January-April 2020: a travel network-based modelling study (2020) medRxiv, , https://doi.org/10.1101/2020.02.04.20020479; Li, G., De Clercq, E., Therapeutic options for the 2019 novel coronavirus (2019-nCoV) (2020) Nature Rev Drug Discov, , https://doi.org/10.1038/d41573-020-00016-0, [Epub ahead of print]; Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med, , https://doi.org/10.1056/NEJMoa2001316, [Epub ahead of print]; Li, J., Li, J., Xie, X., Cai, X., Huang, J., Tian, X., Zhu, H., Game consumption and the 2019 novel coronavirus (2020) Lancet Infect Dis, , [Epub 2020 Feb 7]; Liang, W., Feng, Z., Rao, S., Xiao, C., Xue, X., Lin, Z., Diarrhoea may be underestimated: a missing link in 2019 novel coronavirus (2020) Gut, , [Epub ahead of print]; Lu, R., Zhao, X., Li, J., Niu, P., Yang, B., Wu, H., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet, 395, pp. 565-574; Maxmen, A., More than 80 clinical trials launch to test coronavirus treatments (2020) Nature, 578, pp. 347-348; Rothe, C., Schunk, M., Sothmann, P., Bretzel, G., Froeschl, G., Wallrauch, C., Transmission of 2019-nCoV infection from an asymptomatic contact in Germany (2020) N Engl J Med, , https://doi.org/10.1056/NEJMc2001468, [Epub ahead of print]; Sheahan, T.P., Sims, A.C., Leist, S.R., Schäfer, A., Won, J., Brown, A.J., Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV (2020) Nat Commun, 11, p. 222; Te, K.K., Tsang, O.T., Yip, C.C.-Y., Chan, K.H., Wu, T.C., Chan, J.M.C., Consistent detection of 2019 novel coronavirus in saliva (2020) Clin Infect Dis, , [Epub ahead of print]; Vetter, P., Eckerle, I., Kaiser, L., Covid-19: a puzzle with many missing pieces (2020) BMJ, 368, p. m627; Wang, M., Cao, R., Zhang, L., Yang, X., Liu, J., Xu, M., Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro (2020) Cell Res, , https://doi.org/10.1038/s41422-020-0282-0, [Epub ahead of print]; Wang, C., Horby, P.W., Hayden, F.G., Gao, G.F., A novel coronavirus outbreak of global health concern (2020) Lancet, 395, pp. 470-473; Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) JAMA, , https://doi.org/10.1001/jama.2020.1585, [Epub ahead of print]; Wei, M., Yuan, J., Liu, Y., Fu, T., Yu, X., Zhang, Z.J., Novel Coronavirus Infection in Hospitalized Infants Under 1 Year of Age in China (2020) JAMA, , https://doi.org/10.1001/jama.2020.2131, [Epub ahead of print]; de Wit, E., Feldmann, F., Cronin, J., Jordan, R., Okumura, A., Thomas, T., Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection (2020) Proc Natl Acad Sci USA, , [Epub ahead of print]; Wu, Z., McGoogan, J.M., Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) Outbreak in china: summary of a report of 72 314 cases from the Chinese Center for disease control and prevention (2020) JAMA, , [Epub ahead of print]; Wu, J.T., Leung, K., Leung, G.M., Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study (2020) Lancet, 395, pp. 689-697; Wu, A., Peng, Y., Huang, B., Ding, X., Wang, X., Niu, P., Genome composition and divergence of the novel coronavirus (2019-nCoV) originating in China (2020) Cell Host Microbe, pp. 1931-3128. , [Epub ahead of print]; Wu, F., Zhao, S., Yu, B., Chen, Y.M., Wang, W., Song, Z.G., A new coronavirus associated with human respiratory disease in China (2020) Nature, , https://doi.org/10.1038/s41586-020-2008-3, [Epub ahead of print]; Xu, X.W., Wu, X.X., Jiang, X.G., Xu, K.J., Ying, L.J., Ma, C.L., Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series (2020) BMJ, 368, p. m606; Zhang, L., Shen, F.M., Chen, F., Lin, Z., Origin and evolution of the 2019 novel coronavirus (2020) Clin Infect Dis, , [Epub ahead of print]; Zhang, J., Zhou, L., Yang, Y., Peng, W., Wang, W., Chen, X., Therapeutic and triage strategies for 2019 novel coronavirus disease in fever clinics (2020) Lancet Respir Med, , [Epub ahead of print]; Zhou, P., Yang, X.L., Wang, X.G., Hu, B., Zhang, L., Zhang, W., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature, , https://doi.org/10.1038/s41586-020-2012-7, [Epub ahead of print]; Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382, pp. 727-733","Brüssow, H.; Department of Biosystems, Group of Gene Technology, KU LeuvenBelgium; email: haraldbruessow@yahoo.com",,John Wiley and Sons Ltd,17517907,,,32144890,English,Microb. Biotechnol.,Note,Final,Open Access,Scopus,2-s2.0-85081638445,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wu P., Hao X., Lau E.H.Y., Wong J.Y., Leung K.S.M., Wu J.T., Cowling B.J., Leung G.M.",57215295247;57215298157;7103086074;54390180800;57194749530;7409256423;8644765500;7007159841;,"Real-time tentative assessment of the epidemiological characteristics of novel coronavirus infections in Wuhan, China, as at 22 January 2020",2020,Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin,25,3,,,,,7,10.2807/1560-7917.ES.2020.25.3.2000044,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078688233&doi=10.2807%2f1560-7917.ES.2020.25.3.2000044&partnerID=40&md5=c46d4f706894f33a0978c4ad6f4c5477,"World Health Organization (WHO) Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China; These authors are joint senior authors with equal contribution","Wu, P., World Health Organization (WHO) Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China; Hao, X., World Health Organization (WHO) Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China; Lau, E.H.Y., World Health Organization (WHO) Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China; Wong, J.Y., World Health Organization (WHO) Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China; Leung, K.S.M., World Health Organization (WHO) Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China; Wu, J.T., World Health Organization (WHO) Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China; Cowling, B.J., World Health Organization (WHO) Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China, These authors are joint senior authors with equal contribution; Leung, G.M., World Health Organization (WHO) Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China, These authors are joint senior authors with equal contribution","A novel coronavirus (2019-nCoV) causing severe acute respiratory disease emerged recently in Wuhan, China. Information on reported cases strongly indicates human-to-human spread, and the most recent information is increasingly indicative of sustained human-to-human transmission. While the overall severity profile among cases may change as more mild cases are identified, we estimate a risk of fatality among hospitalised cases at 14% (95% confidence interval: 3.9-32%).",Coronavirus; public health,"China; classification; communicable disease; Coronavirinae; Coronavirus infection; epidemic; hospital mortality; hospitalization; human; isolation and purification; mortality; public health; respiratory tract infection; risk assessment; China; Communicable Diseases, Emerging; Coronavirus; Coronavirus Infections; Disease Outbreaks; Hospital Mortality; Hospitalization; Humans; Public Health; Respiratory Tract Infections; Risk Assessment",,,,NLM (Medline),15607917,,,31992388,English,Euro Surveill.,Article,Final,Open Access,Scopus,2-s2.0-85078688233,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Nilsson A., Edner N., Albert J., Ternhag A.",23568617400;54917526700;7201985763;8873924600;,Fatal encephalitis associated with coronavirus OC43 in an immunocompromised child,2020,Infectious Diseases,,,,,,,,10.1080/23744235.2020.1729403,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079740852&doi=10.1080%2f23744235.2020.1729403&partnerID=40&md5=8eb3d4723fd9fffca05ce543cd67e9f2,"Department of Women’s and Children’s Health, Childhood Cancer Research Unit, Astrid Lindgren Children’s Hospital, Karolinska Institutet, Stockholm, Sweden; Department of Microbiology, Public Health Agency of Sweden, Solna, Sweden; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden; Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine Solna, Unit for Infectious Diseases, Karolinska Institutet, Stockholm, Sweden","Nilsson, A., Department of Women’s and Children’s Health, Childhood Cancer Research Unit, Astrid Lindgren Children’s Hospital, Karolinska Institutet, Stockholm, Sweden; Edner, N., Department of Microbiology, Public Health Agency of Sweden, Solna, Sweden; Albert, J., Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden, Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden; Ternhag, A., Department of Medicine Solna, Unit for Infectious Diseases, Karolinska Institutet, Stockholm, Sweden","A child with pre-B acute lymphoblastic leukaemia (ALL) developed fatal encephalitis associated with human coronavirus OC43 (HCoV-OC43). During chemotherapy the child had a persistent HCoV-OC43 respiratory infection and later developed progressive encephalitis. Cerebrospinal fluid was negative for pathogens including HCoV-OC43, but a brain biopsy was HCoV-OC43-positive by metagenomic next-generation sequencing. © 2020, © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.",brain biopsy; Coronavirus; encephalitis; next generation sequencing,,"Spaan, W., Cavanagh, D., Horzinek, M.C., Coronaviruses–structure and genome expression (1988) J Gen Virol, 69 (12), pp. 2939-2952; Lee, J., Storch, G.A., Characterization of human coronavirus OC43 and human coronavirus NL63 infections among hospitalized children <5 years of age (2014) Pediatr Infect Dis J, 33 (8), pp. 814-820; Wickstrom, R., Review of the aetiology, diagnostics and outcomes of childhood encephalitis from 1970 to 2009 (2017) Acta Paediatrica, 106, pp. 463-469; Toft, N., Birgens, H., Abrahamsson, J., Results of NOPHO ALL2008 treatment for patients aged 1–45 years with acute lymphoblastic leukemia (2018) Leukemia, 32 (3), pp. 606-615; Morfopoulou, S., Brown, J.R., Davies, E.G., Human coronavirus OC43 associated with fatal encephalitis (2016) N Engl J Med, 375 (5), pp. 497-498; Tiveljung-Lindell, A., Rotzén-Östlund, M., Gupta, S., Development and implementation of a molecular diagnostic platform for daily rapid detection of 15 respiratory viruses (2009) J Med Virol, 81 (1), pp. 167-175; Chan, J.F.-W., Yao, Y., Yeung, M.-L., Treatment with lopinavir/ritonavir or interferon-beta 1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset (2015) J Infect Dis, 212 (12), pp. 1904-1913; Arabi, Y.M., Alothman, A., Balkhy, H.H., Treatment of middle east respiratory syndrome with a combination of lopinavir-ritonavir and interferon-beta1b (MIRACLE trial): study protocol for a randomized controlled trial (2018) Trials, 19 (1), p. 81; Brown, J.R., Bharucha, T., Breuer, J., Encephalitis diagnosis using metagenomics: application of next generation sequencing for undiagnosed cases (2018) J Infect, 76 (3), pp. 225-240; Dhawan, S., He, Y., Bartek, J., Comparison of frame-based versus frameless intracranial stereotactic biopsy: systematic review and meta-analysis (2019) World Neurosurg, 127, p. 616; Riche, M., Amelot, A., Peyre, M., Complications after frame-based stereotactic brain biopsy: A systematic review Neurosurg Rev, , cited 2020 Jan 4","Ternhag, A.; Department of Medicine Solna, Unit for Infectious Diseases, Karolinska InstitutetSweden; email: anders.ternhag@sll.se",,Taylor and Francis Ltd.,23744235,,,32067542,English,Infect. Dis.,Article,Article in Press,Open Access,Scopus,2-s2.0-85079740852,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Pullano G., Pinotti F., Valdano E., Boëlle P.-Y., Poletto C., Colizza V.",57211513682;57209288568;56582534900;7003593801;56586291300;8225873300;,"Novel coronavirus (2019-nCoV) early-stage importation risk to Europe, January 2020",2020,Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin,25,4,,,,,5,10.2807/1560-7917.ES.2020.25.4.2000057,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079006613&doi=10.2807%2f1560-7917.ES.2020.25.4.2000057&partnerID=40&md5=cb8ae3e92f9b1733133562885ec650eb,"INSERM, Sorbonne Université, Institut Pierre Louis d'Epidémiologie et de Santé Publique, IPLESP, Paris, France; Center for Biomedical Modeling, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, United States","Pullano, G., INSERM, Sorbonne Université, Institut Pierre Louis d'Epidémiologie et de Santé Publique, IPLESP, Paris, France; Pinotti, F., INSERM, Sorbonne Université, Institut Pierre Louis d'Epidémiologie et de Santé Publique, IPLESP, Paris, France; Valdano, E., Center for Biomedical Modeling, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, United States; Boëlle, P.-Y., INSERM, Sorbonne Université, Institut Pierre Louis d'Epidémiologie et de Santé Publique, IPLESP, Paris, France; Poletto, C., INSERM, Sorbonne Université, Institut Pierre Louis d'Epidémiologie et de Santé Publique, IPLESP, Paris, France; Colizza, V., INSERM, Sorbonne Université, Institut Pierre Louis d'Epidémiologie et de Santé Publique, IPLESP, Paris, France","As at 27 January 2020, 42 novel coronavirus (2019-nCoV) cases were confirmed outside China. We estimate the risk of case importation to Europe from affected areas in China via air travel. We consider travel restrictions in place, three reported cases in France, one in Germany. Estimated risk in Europe remains high. The United Kingdom, Germany and France are at highest risk. Importation from Beijing and Shanghai would lead to higher and widespread risk for Europe.",2019-nCoV; Europe; importation risk; travel ban,"COVID-19; severe acute respiratory syndrome coronavirus 2; aviation; Betacoronavirus; China; Coronavirus infection; epidemic; Europe; human; public policy; risk assessment; theoretical model; virus pneumonia; Air Travel; Betacoronavirus; China; Coronavirus Infections; Disease Outbreaks; Europe; Humans; Models, Theoretical; Pneumonia, Viral; Public Policy; Risk Assessment",,,,NLM (Medline),15607917,,,32019667,English,Euro Surveill.,Article,Final,Open Access,Scopus,2-s2.0-85079006613,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "McKay L.A., Meachem M., Snead E., Brannen T., Mutlow N., Ruelle L., Davies J.L., van der Meer F.",57213671433;55194758700;57203160073;57213672375;57213672389;57213672743;13408508000;55774976900;,Prevalence and mutation analysis of the spike protein in feline enteric coronavirus and feline infectious peritonitis detected in household and shelter cats in western Canada,2020,Canadian Journal of Veterinary Research,84,1,,18,23,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077942197&partnerID=40&md5=50078eba45fc8798af8ebc7cc7d705b0,"Department of Ecosystem and Public Health, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada; Diagnostic Services Unit, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada; Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada; Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada; Meow Foundation, Calgary, AB, Canada; Fish Creek Pet Hospital, Calgary, AB, Canada; Wild Rose Cat Clinic, Calgary, AB, Canada","McKay, L.A., Department of Ecosystem and Public Health, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada; Meachem, M., Department of Veterinary Pathology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada; Snead, E., Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada; Brannen, T., Meow Foundation, Calgary, AB, Canada; Mutlow, N., Fish Creek Pet Hospital, Calgary, AB, Canada; Ruelle, L., Wild Rose Cat Clinic, Calgary, AB, Canada; Davies, J.L., Department of Ecosystem and Public Health, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada, Diagnostic Services Unit, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada; van der Meer, F., Department of Ecosystem and Public Health, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada","Feline infectious peritonitis (FIP) is a fatal disease for which no simple antemortem diagnostic assay is available. A new polymerase chain reaction (PCR) test has recently been developed that targets the spike protein region of the FIP virus (FIPV) and can identify specific mutations (M1030L or S1032A), the presence of which indicates a shift from feline enteric coronavirus (FeCV) to FIPV. This test will only be useful in the geographical region of interest, however, if the FIP viruses contain these mutations. The primary objective of this study was to determine the presence of the M1030L or S1032A mutations in FeCV derived from stool samples from a selected group of healthy cats from households and shelters and determine how many of these cats excrete FeCV. The secondary objective was to evaluate how often these specific FIPV mutations were present in tissue samples derived from cats diagnosed with FIP at postmortem examination. Feline enteric coronavirus (FeCV) was detected in 46% of fecal samples (86/185), all were FeCV type 1, with no difference between household or shelter cats. Only 45% of the FIPV analyzed contained the previously reported M1030L or S1032A mutations. It should be noted that, as the pathological tissue samples were opportunistically obtained and not specifically obtained for PCR testing, caution is warranted in interpreting these data. © 2020, Canadian Veterinary Medical Association. All rights reserved.",,virus spike protein; vitronectin; 3' untranslated region; amino acid sequence; animal tissue; Article; autopsy; Canada; cat; feces analysis; feline infectious peritonitis; Feline infectious peritonitis virus; female; gene mutation; gene sequence; histopathology; immunohistochemistry; nested polymerase chain reaction; nonhuman; phylogeny; prevalence; reverse transcription polymerase chain reaction; RNA extraction; Sanger sequencing; sequence alignment; sequence analysis,"Kahn, C.M., Line, S., (2010) The Merck Veterinary Manual, , 10th ed. Whitehouse Station, New Jersey: Merck; Kipar, A., Meli, M.L., Feline infectious peritonitis: Still an enigma? (2014) Vet Pathol, 51, pp. 505-526; Kummrow, M., Meli, M.L., Haessig, M., Feline coronavirus serotypes 1 and 2: Seroprevalence and association with disease in Switzerland (2005) Clin Diagn Lab Immunol, 12, pp. 1209-1215; Pedersen, N.C., An update on feline infectious peritonitis: Virology and immunopathogenesis (2014) Vet J, 201, pp. 123-132; Chang, H.W., Egberink, H.F., Halpin, R., Spiro, D.J., Rottier, P.J., Spike protein fusion peptide and feline coronavirus virulence (2012) Emerg Infect Dis, 18, pp. 1089-1095; Lewis, C.S., Porter, E., Matthews, D., Genotyping coronavi-ruses associated with feline infectious peritonitis (2015) J Gen Virol, 96, pp. 1358-1368; Licitra, B.N., Millet, J.K., Regan, A.D., Mutation in spike protein cleavage site and pathogenesis of feline coronavirus (2013) Emerg Infect Dis, 19, pp. 1066-1073; Giori, L., Giordano, A., Giudice, C., Grieco, V., Paltrinieri, S., Performances of different diagnostic tests for feline infectious peritonitis in challenging clinical cases (2011) J Small Anim Pract, 52, pp. 152-157; (2015) IDEXX Laboratories, , https:/idexxcom-live-b02da1e51e754c9cb292133b-9c56c33.aldryn-media.com/filer_public/dd/81/dd8192c9-ae9b-4d1b-841a-06748adc75ac/feline-infectious-peritonitis-virus.pdf; Pedersen, N.C., Sato, R., Foley, J.E., Poland, A.M., Common virus infections in cats, before and after being placed in shelters, with emphasis on feline enteric coronavirus (2004) J Feline Med Surg, 6, pp. 83-88; Herrewegh, A.A., de Groot, R.J., Cepica, A., Egberink, H.F., Horzinek, M.C., Rottier, P.J., Detection of feline coronavirus RNA in feces, tissues, and body-fluids of naturally infected cats by reverse-transcriptase PCR (1995) J Clin Microbiol, 33, pp. 684-689; Sievers, F., Wilm, A., Dineen, D., Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega (2011) Mol Syst Biol, 7; Posada, D., JModelTest: Phylogenetic model averaging (2008) Mol Biol Evol, 25, pp. 1253-1256; Guindon, S., Dufayard, J.F., Hordijk, W., Lefort, V., Gascuel, O., PhyML: Fast and accurate phylogeny reconstruction by maximum likelihood (2009) Infect Genet Evol, 9, pp. 384-385; Pedersen, N.C., Liu, H., Dodd, K.A., Pesavento, P.A., Significance of coronavirus mutants in feces and diseased tissues of cats suffering from feline infectious peritonitis (2009) Viruses, 1, pp. 166-184; Chang, H.W., de Groot, R.J., Egberink, H.F., Rottier, P.J., Feline infectious peritonitis: Insights into feline coronavirus pathobiogenesis and epidemiology based on genetic analysis of the viral 3c gene (2010) J Gen Virol, 91, pp. 415-420; Brown, M.A., Troyer, J.L., Pecon-Slattery, J., Roelke, M.E., O’Brien, S.J., Genetics and pathogenesis of feline infectious peritonitis virus (2009) Emerg Infect Dis, 15, pp. 1445-1452; Domingo, E., Sheldon, J., Perales, C., Viral quasispecies evolution (2012) Microbiol Mol Biol Rev, 76, pp. 159-216","van der Meer, F.; Department of Ecosystem and Public Health, Faculty of Veterinary Medicine, University of CalgaryCanada; email: Frank.vandermeer@ucalgary.ca",,Canadian Veterinary Medical Association,8309000,,CJVRE,31949325,English,Can. J. Vet. Res.,Article,Final,,Scopus,2-s2.0-85077942197,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Ye G., Pan Z., Pan Y., Deng Q., Chen L., Li J., Li Y., Wang X.",57214729717;57215819090;57215824205;57215823638;57215684032;57215824775;27172163600;57211283467;,Clinical characteristics of severe acute respiratory syndrome coronavirus 2 reactivation,2020,Journal of Infection,,,,,,,,10.1016/j.jinf.2020.03.001,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081964978&doi=10.1016%2fj.jinf.2020.03.001&partnerID=40&md5=b3f379eec60b46a741edb36e0f88e66c,"Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, China; Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, China; Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China; Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China","Ye, G., Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, China; Pan, Z., Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, China; Pan, Y., Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, China; Deng, Q., Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, China; Chen, L., Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, China; Li, J., Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, China; Li, Y., Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, Hubei, China; Wang, X., Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China, Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China","Objectives: Previous studies on the pneumonia outbreak caused by the 2019 novel coronavirus disease (COVID-19) were based on information from the general population. However, limited data was available for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reactivation. This study aimed to evaluate the clinical characteristics of the SARS-CoV-2 reactivation. Methods: Clinical records, laboratory results, and chest CT scans were retrospectively reviewed for 55 patients with laboratory-confirmed COVID-19 pneumonia (i.e., with throat swab samples that were positive for SARS-CoV-2) who were admitted to Zhongnan Hospital of Wuhan University, Wuhan, China, from Jan. 8 to Feb. 10, 2020. Results: All 55 patients had a history of epidemiological exposure to COVID-19, and 5 (9%) patients who discharged from hospital presented with SARS-CoV-2 reactivation. Among the 5 reactivated patients, other symptoms were also observed, including fever, cough, sore throat, and fatigue. One of the 5 patients had progressive lymphopenia (from 1.3 to 0.56 × 109 cells per L) and progressive neutrophilia (from 4.5 to 18.28 × 109 cells per L). All 5 reactivated patients presented normal aminotransferase levels. Throat swab samples from the 5 reactivated patients were tested for SARS-CoV-2, indicating all positive for the virus. Conclusions: Findings from this small group of cases suggested that there was currently evidence for reactivation of SARS-CoV-2 and there might be no specific clinical characteristics to distinguish them. © 2020",COVID-19; CT scan; Laboratory medicine; SARS-CoV-2,,"Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382 (8), pp. 727-733; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395 (10223), pp. 497-506; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395 (10223), pp. 507-513; Lu, R., Zhao, X., Li, J., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet, 395 (10224), pp. 565-574; Zhou, P., Yang, X.L., Wang, X.G., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature; Corman, V.M., Landt, O., Kaiser, M., Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR (2020) Euro Surveil Bull Eur Maladies Transm = Eur Commun Dis Bull, 25 (3); (2020), https://wwwwhoint/publications-detail/laboratory-testing-for-2019-novel-coronavirus-in-suspected-human-cases-20200117, WHO. Laboratory testing for 2019 novel coronavirus (2019-nCoV) in suspected human cases. Interim guidance. (Accessed 4 February 2020); Zou, L., Ruan, F., Huang, M., SARS-CoV-2 viral load in upper respiratory specimens of infected patients (2020) N Engl J Med; Lowenberg, M., Verhaar, A.P., van den Brink, G.R., Hommes, D.W., Glucocorticoid signaling: a nongenomic mechanism for T-cell immunosuppression (2007) Trends Mol Med, 13 (4), pp. 158-163","Li, Y.; Department of Laboratory Medicine, Zhongnan Hospital of Wuhan UniversityChina; email: liyirong838@163.com",,W.B. Saunders Ltd,1634453,,JINFD,32171867,English,J. Infect.,Article,Article in Press,Open Access,Scopus,2-s2.0-85081964978,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Ahmed S.F., Quadeer A.A., McKay M.R.",55456831400;24778449700;8915674500;,Preliminary identification of potential vaccine targets for the COVID-19 Coronavirus (SARS-CoV-2) Based on SARS-CoV Immunological Studies,2020,Viruses,12,3,254,,,,1,10.3390/v12030254,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081251137&doi=10.3390%2fv12030254&partnerID=40&md5=19a102c3a5a503347f3f5d4fea415d4a,"Department of Electronic and Computer Engineering, Hong Kong University of Science and Technology, Hong Kong; Department of Chemical and Biological Engineering, Hong Kong University of Science and Technology, Hong Kong","Ahmed, S.F., Department of Electronic and Computer Engineering, Hong Kong University of Science and Technology, Hong Kong; Quadeer, A.A., Department of Electronic and Computer Engineering, Hong Kong University of Science and Technology, Hong Kong; McKay, M.R., Department of Electronic and Computer Engineering, Hong Kong University of Science and Technology, Hong Kong, Department of Chemical and Biological Engineering, Hong Kong University of Science and Technology, Hong Kong","The beginning of 2020 has seen the emergence of COVID-19 outbreak caused by a novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). There is an imminent need to better understand this new virus and to develop ways to control its spread. In this study, we sought to gain insights for vaccine design against SARS-CoV-2 by considering the high genetic similarity between SARS-CoV-2 and SARS-CoV, which caused the outbreak in 2003, and leveraging existing immunological studies of SARS-CoV. By screening the experimentallydetermined SARS-CoV-derived B cell and T cell epitopes in the immunogenic structural proteins of SARS-CoV, we identified a set of B cell and T cell epitopes derived from the spike (S) and nucleocapsid (N) proteins that map identically to SARS-CoV-2 proteins. As no mutation has been observed in these identified epitopes among the 120 available SARS-CoV-2 sequences (as of 21 February 2020), immune targeting of these epitopes may potentially offer protection against this novel virus. For the T cell epitopes, we performed a population coverage analysis of the associated MHC alleles and proposed a set of epitopes that is estimated to provide broad coverage globally, as well as in China. Our findings provide a screened set of epitopes that can help guide experimental efforts towards the development of vaccines against SARS-CoV-2. © 2020 by the authors.",2019 novel coronavirus; 2019-nCoV; B cell epitopes; Coronavirus; COVID-19; MERS-CoV; SARS-CoV; SARS-CoV-2; T cell epitopes; Vaccine,"2019 novel coronavirus vaccine; epitope; HLA A antigen; HLA B antigen; HLA C antigen; HLA DRB1 antigen; M protein; nucleocapsid protein; unclassified drug; virus spike protein; virus vaccine; coronavirus spike glycoprotein; COVID-19; nucleocapsid protein, Coronavirus; severe acute respiratory syndrome coronavirus 2; virus vaccine; 2019 novel coronavirus; allele; amino acid sequence; antigen binding; Article; B lymphocyte; binding assay; bioinformatics; cell assay; data processing; drug design; drug targeting; enzyme linked immunosorbent assay; enzyme linked immunospot assay; epitope mapping; genetic similarity; human; immune response; maximum likelihood method; Middle East respiratory syndrome coronavirus; nonhuman; nucleotide sequence; phylogenetic tree; SARS coronavirus; sequence alignment; sequence analysis; T lymphocyte; whole genome sequencing; Betacoronavirus; Coronavirus infection; genetics; immunology; phylogeny; protein tertiary structure; virus genome; virus pneumonia; Betacoronavirus; Coronavirus Infections; Epitope Mapping; Epitopes, B-Lymphocyte; Epitopes, T-Lymphocyte; Genome, Viral; Humans; Nucleocapsid Proteins; Phylogeny; Pneumonia, Viral; Protein Structure, Tertiary; SARS Virus; Spike Glycoprotein, Coronavirus; Viral Vaccines","Wang, C., Horby, P.W., Hayden, F.G., Gao, G.F., A novel coronavirus outbreak of global health concern (2020) Lancet, 395, pp. 470-473; https://www.cdc.gov/coronavirus/2019-ncov/locations-confirmed-cases.html, Centers-of-Disease-Control-and-Prevention Confirmed 2019-nCoV cases globally (accessed on 31 January 2020); https://www.who.int/news-room/detail/30-01-2020-statement-on-The-second-meeting-of-theinternational-health-regulations-(2005)-emergency-committee-regarding-The-outbreak-of-novelcoronavirus-(2019-ncov), World-Health-Organization Statement on the second meeting of the International Health Regulations (2005) Emergency Committee regarding the outbreak of novel coronavirus (2019-nCoV (accessed on 31 January 2020); https://www.who.int/emergencies/diseases/novel-coronavirus-2019, World-Health-Organization Coronavirus disease (COVID-19) outbreak (accessed on 31 January 2020); https://www.who.int/news-room/detail/23-01-2020-statement-on-The-meeting-of-The-international-healthregulations-(2005)-emergency-committee-regarding-The-outbreak-of-novel-coronavirus-(2019-ncov), World-Health-Organization Statement on the meeting of the International Health Regulations (2005) Emergency Committee regarding the outbreak of novel coronavirus (2019-nCoV) (accessed on 31 January 2020); Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Gu, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506; Heymann, D.L., Data sharing and outbreaks: Best practice exemplified (2020) Lancet, 395, pp. 469-470; Liu, X., Wang, X.-J., Potential Inhibitors for 2019-nCoV Coronavirus M Protease from Clinically Approved Medicines, , bioRxiv 2020.01.29.924100 2020; 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Virol., 88, pp. 7628-7644; Ahmed, S.F., Quadeer, A.A., Morales-Jimenez, D., McKay, M.R., Sub-dominant principal components inform new vaccine targets for HIV Gag (2019) Bioinformatics, 35, pp. 3884-3889; Quadeer, A.A., Morales-Jimenez, D., McKay, M.R., Co-evolution networks of HIV/HCV are modular with direct association to structure and function (2018) PLOS Comput. Biol., 14, p. e1006409; Prabakaran, P., Gan, J., Feng, Y., Zhu, Z., Choudhry, V., Xiao, X., Ji, X., Dimitrov, D.S., Structure of severe acute respiratory syndrome coronavirus receptor-binding domain complexed with neutralizing antibody (2006) J. Biol. Chem., 281, pp. 15829-15836; Zhu, Z., Chakraborti, S., He, Y., Roberts, A., Sheahan, T., Xiao, X., Hensley, L.E., Sidorov, I.A., Potent cross-reactive neutralization of SARS coronavirus isolates by human monoclonal antibodies (2007) Proc. Natl. Acad. 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Sci., 114, pp. 11157-11162; Song, W., Gui, M., Wang, X., Xiang, Y., Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2 (2018) PLOS Pathog., 14, p. e1007236; Wrapp, D., Wang, N., Corbett, K.S., Goldsmith, J.A., Hsieh, C.-L., Abiona, O., Graham, B.S., McLellan, J.S., Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation (2020) Science., 2011, p. eabb2507; Tian, X., Li, C., Huang, A., Xia, S., Lu, S., Shi, Z., Lu, L., Wu, Y., Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody (2020) Emerg. Microbes Infect., 9, pp. 382-385; Ferguson, A.L., Mann, J.K., Omarjee, S., Ndung'U, T., Walker, B.D., Chakraborty, A.K., Translating HIV sequences into quantitative fitness landscapes predicts viral vulnerabilities for rational immunogen design (2013) Immunity, 38, pp. 606-617; Chakraborty, A.K., Barton, J.P., Rational design of vaccine targets and strategies for HIV: A crossroad of statistical physics, biology, and medicine (2017) Reports Prog. Phys., 80, p. 032601; Quadeer, A.A., Louie, R.H.Y., McKay, M.R., Identifying immunologically-vulnerable regions of the HCV E2 glycoprotein and broadly neutralizing antibodies that target them (2019) Nat. Commun., 10, p. 2073; Louie, R.H.Y., Kaczorowski, K.J., Barton, J.P., Chakraborty, A.K., McKay, M.R., Fitness landscape of the human immunodeficiency virus envelope protein that is targeted by antibodies (2018) Proc. Natl. Acad. Sci., 115, pp. E564-E573; Quadeer, A.A., Barton, J.P., Chakraborty, A.K., McKay, M.R., Deconvolving mutational patterns of poliovirus outbreaks reveals its intrinsic fitness landscape (2020) Nat. Commun., 11, p. 377; Mann, J.K., Barton, J.P., Ferguson, A.L., Omarjee, S., Walker, B.D., Chakraborty, A., Ndung'U, T., The fitness landscape of HIV-1 Gag: Advanced modeling approaches and validation of model predictions by in vitro testing (2014) PLoS Comput. Biol., 10, p. e1003776; Ramaiah, A., Arumugaswami, V., (2020) Insights into Cross-species Evolution of Novel Human Coronavirus 2019-nCoV and Defining Immune Determinants for Vaccine Development, , bioRxiv 01.29.925867 2020","Quadeer, A.A.; Department of Electronic and Computer Engineering, Hong Kong University of Science and TechnologyHong Kong; email: eeaaquadeer@ust.hk.com",,MDPI AG,19994915,,,32106567,English,Viruses,Article,Final,Open Access,Scopus,2-s2.0-85081251137,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhang J., Han Y., Shi H., Chen J., Zhang X., Wang X., Zhou L., Liu J., Zhang J., Ji Z., Jing Z., Ma J., Shi D., Feng L.",57211015345;57211015266;55233443300;8320190900;55851450100;56979423400;55861714100;55317283900;57192714108;57192713776;57197728593;7406199976;54399296900;55792011500;,Swine acute diarrhea syndrome coronavirus-induced apoptosis is caspase- and cyclophilin D- dependent,2020,Emerging Microbes and Infections,9,1,,439,456,,,10.1080/22221751.2020.1722758,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079794503&doi=10.1080%2f22221751.2020.1722758&partnerID=40&md5=4e690c4128f3ec6707b2dc5e8a96fd4c,"State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China; College of Animal Science, South China Agricultural University, Guangzhou, China","Zhang, J., State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China; Han, Y., State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China; Shi, H., State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China; Chen, J., State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China; Zhang, X., State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China; Wang, X., State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China; Zhou, L., College of Animal Science, South China Agricultural University, Guangzhou, China; Liu, J., State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China; Zhang, J., State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China; Ji, Z., State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China; Jing, Z., State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China; Ma, J., College of Animal Science, South China Agricultural University, Guangzhou, China; Shi, D., State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China; Feng, L., State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China","Swine acute diarrhea syndrome coronavirus (SADS-CoV), a newly discovered enteric coronavirus, is the aetiological agent that causes severe clinical diarrhea and intestinal pathological damage in piglets. To understand the effect of SADS-CoV on host cells, we characterized the apoptotic pathways and elucidated mechanisms underlying the process of apoptotic cell death after SADS-CoV infection. SADS-CoV-infected cells showed evidence of apoptosis in vitro and in vivo. The use of a pan-caspase inhibitor resulted in the inhibition of SADS-CoV-induced apoptosis and reduction in SADS-CoV replication, suggestive of the association of a caspase-dependent pathway. Furthermore, SADS-CoV infection activated the initiators caspase-8 and -9 and upregulated FasL and Bid cleavage, demonstrating a crosstalk between the extrinsic and intrinsic pathways. However, the proapoptotic proteins Bax and Cytochrome c (Cyt c) relocalized to the mitochondria and cytoplasm, respectively, after infection by SADS-CoV. Moreover, Vero E6 and IPI-2I cells treated with cyclosporin A (CsA), an inhibitor of mitochondrial permeability transition pore (MPTP) opening, were completely protected from SADS-CoV-induced apoptosis and viral replication, suggesting the involvement of cyclophilin D (CypD) in these processes. Altogether, our results indicate that caspase-dependent FasL (extrinsic)- and mitochondria (intrinsic)- mediated apoptotic pathways play a central role in SADS-CoV-induced apoptosis that facilitates viral replication. In summary, these findings demonstrate mechanisms by which SADS-CoV induces apoptosis and improve our understanding of SADS-CoV pathogenesis. © 2020, © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd.",apoptosis; apoptosis-inducing factor; pathogenesis; SADS-CoV,caspase; cyclophilin D; Swine acute diarrhea syndrome coronavirus; Alphacoronavirus; animal; apoptosis; Chlorocebus aethiops; Coronavirus infection; genetics; metabolism; physiology; pig; Vero cell line; virology; virus replication; Alphacoronavirus; Animals; Apoptosis; Caspases; Chlorocebus aethiops; Coronavirus Infections; Cyclophilin D; Swine; Vero Cells; Virus Replication,"Galluzzi, L., Kepp, O., Trojel-Hansen, C., Mitochondrial control of cellular life, stress, and death (2012) Circ Res, 111 (9), pp. 1198-1207; Kroemer, G., Galluzzi, L., Vandenabeele, P., Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009 (2009) Cell Death Differ, 16 (1), pp. 3-11; Arch, R.H., Thompson, C.B., Lymphocyte survival–the struggle against death (1999) Annu Rev Cell Dev Biol, 15, pp. 113-140; Shih, W.L., Hsu, H.W., Liao, M.H., Avian reovirus sigmaC protein induces apoptosis in cultured cells (2004) Virology, 321 (1), pp. 65-74; Everett, H., McFadden, G., Apoptosis: an innate immune response to virus infection (1999) Trends Microbiol, 7 (4), pp. 160-165; Lee, S.M., Kleiboeker, S.B., Porcine reproductive and respiratory syndrome virus induces apoptosis through a mitochondria-mediated pathway (2007) Virology, 365 (2), pp. 419-434; Cryns, V., Yuan, J., Proteases to die for (1998) Genes Dev, 12 (11), pp. 1551-1570; O’Brien, V., Viruses and apoptosis (1998) J Gen Virol, 79, pp. 1833-1845; Razvi, E.S., Welsh, R.M., Apoptosis in viral infections (1995) Adv Virus Res, 45, pp. 1-60; Ding, L., Xu, X., Huang, Y., Transmissible gastroenteritis virus infection induces apoptosis through FasL- and mitochondria-mediated pathways (2012) Vet Microbiol, 158 (1-2), pp. 12-22; Kim, Y., Lee, C., Porcine epidemic diarrhea virus induces caspase-independent apoptosis through activation of mitochondrial apoptosis-inducing factor (2014) Virology, 460-461, pp. 180-193; Lee, Y.J., Lee, C., Porcine deltacoronavirus induces caspase-dependent apoptosis through activation of the cytochrome c -mediated intrinsic mitochondrial pathway (2018) Virus Res, 253, pp. 112-123; Ziebuhr, J., Snijder, E.J., Gorbalenya, A.E., Virus-encoded proteinases and proteolytic processing in the Nidovirales (2000) J Gen Virol, 81, pp. 853-879; Siddell, S., Wege, H., Ter Meulen, V., The biology of coronaviruses (1983) J Gen Virol, 64, pp. 761-776; Zhou, P., Fan, H., Lan, T., Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin (2018) Nature, 556 (7700), pp. 255-258; Shi, D., Shi, H., Sun, D., Nucleocapsid Interacts with NPM1 and protects it from proteolytic cleavage, enhancing cell survival, and is involved in PEDV growth (2017) Sci Rep, 7, p. 39700; Han, Y., Zhang, J., Shi, H., Epitope mapping and cellular localization of swine acute diarrhea syndrome coronavirus nucleocapsid protein using a novel monoclonal antibody (2019) Virus Res, , 197752; Hierholzer, J.C., Killington, R.A., Virus isolation and quantitation. 1996; Hinshaw, V.S., Olsen, C.W., Dybdahl-Sissoko, N., Apoptosis: a mechanism of cell killing by influenza A and B viruses (1994) J Virol, 68 (6), pp. 3667-3673; Xue, M., Fu, F., Ma, Y., The PERK Arm of the unfolded protein response negatively regulates transmissible gastroenteritis virus replication by suppressing protein translation and promoting type I interferon production (2018) J Virol, 92 (15), pp. e00431-e418; Thornberry, N.A., Lazebnik, Y., Caspases: enemies within (1998) Science, 281 (5381), pp. 1312-1316; Nicholson, D.W., Thornberry, N.A., Caspases: killer proteases (1997) Trends Biochem Sci, 22 (8), pp. 299-306; Henkart, P.A., ICE family proteases: mediators of all apoptotic cell death? 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(2008) Trends Cell Biol, 18 (4), pp. 157-164; Deng, L., Adachi, T., Kitayama, K., Hepatitis C virus infection induces apoptosis through a Bax-triggered, mitochondrion-mediated, caspase 3-dependent pathway (2008) J Virol, 82 (21), pp. 10375-10385; Pearce, A.F., Lyles, D.S., Vesicular stomatitis virus induces apoptosis primarily through Bak rather than Bax by inactivating Mcl-1 and Bcl-XL (2009) J Virol, 83 (18), pp. 9102-9112; Parquet, M.C., Kumatori, A., Hasebe, F., West Nile virus-induced bax-dependent apoptosis (2001) FEBS Lett, 500 (1-2), pp. 17-24; Green, D.R., Reed, J.C., Mitochondria and apoptosis (1998) Science, 281 (5381), pp. 1309-1312; de Wilde, A.H., Li, Y., van der Meer, Y., Cyclophilin inhibitors block arterivirus replication by interfering with viral RNA synthesis (2013) J Virol, 87 (3), pp. 1454-1464; Kambara, H., Tani, H., Mori, Y., Involvement of cyclophilin B in the replication of Japanese encephalitis virus (2011) Virology, 412 (1), pp. 211-219; Nakagawa, M., Sakamoto, N., Enomoto, N., Specific inhibition of hepatitis C virus replication by cyclosporin A (2004) Biochem Biophys Res Commun, 313 (1), pp. 42-47; Pfefferle, S., Schopf, J., Kogl, M., The SARS-coronavirus-host interactome: identification of cyclophilins as target for pan-coronavirus inhibitors (2011) PLoS Pathog, 7 (10), p. e1002331; Qing, M., Yang, F., Zhang, B., Cyclosporine inhibits flavivirus replication through blocking the interaction between host cyclophilins and viral NS5 protein (2009) Antimicrob Agents Chemother, 53 (8), pp. 3226-3235","Shi, D.; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural SciencesChina; email: shida@caas.cn",,Taylor and Francis Ltd.,22221751,,,32090691,English,Emerg. Microbes Infect.,Article,Final,Open Access,Scopus,2-s2.0-85079794503,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Han Z., Liwen X., Ren M., Sheng J., Ma T., Sun J., Zhao Y., Liu S.",8320191300;57211982223;57203683411;57205460264;57205454697;56171759900;56124143500;35240715000;,"Genetic, antigenic and pathogenic characterization of avian coronaviruses isolated from pheasants (Phasianus colchicus) in China",2020,Veterinary Microbiology,240,,108513,,,,,10.1016/j.vetmic.2019.108513,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85075552311&doi=10.1016%2fj.vetmic.2019.108513&partnerID=40&md5=de0cd166da53f2106d4466349ccb2d91,"Division of Avian Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, the Chinese Academy of Agricultural Sciences, Harbin, 150001, China","Han, Z., Division of Avian Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, the Chinese Academy of Agricultural Sciences, Harbin, 150001, China; Liwen, X., Division of Avian Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, the Chinese Academy of Agricultural Sciences, Harbin, 150001, China; Ren, M., Division of Avian Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, the Chinese Academy of Agricultural Sciences, Harbin, 150001, China; Sheng, J., Division of Avian Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, the Chinese Academy of Agricultural Sciences, Harbin, 150001, China; Ma, T., Division of Avian Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, the Chinese Academy of Agricultural Sciences, Harbin, 150001, China; Sun, J., Division of Avian Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, the Chinese Academy of Agricultural Sciences, Harbin, 150001, China; Zhao, Y., Division of Avian Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, the Chinese Academy of Agricultural Sciences, Harbin, 150001, China; Liu, S., Division of Avian Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, the Chinese Academy of Agricultural Sciences, Harbin, 150001, China","Two viruses were isolated in 2017 from commercial pheasants with severe clinical signs and mortality in Shandong and Anhui provinces, China, respectively. We examined the pathogenic effects of the viruses in chicken embryos and the size and morphology of the virus particles, performed phylogenetic analysis based on the S1 gene and complete genomic sequences, and examined the antibody responses against infectious bronchitis virus (IBV). The results suggested that the viruses I0623/17 and I0710/17 were avian coronaviruses and were identified as pheasant coronaviruses (PhCoV), with greatest similarity to IBV. Further investigations of the antigenicity, complete genome organization, substitutions in multiple genes, and viral pathogenicity, replication, and shedding in chickens and pheasants showed obvious differences between PhCoV and IBV in terms of antigenicity, and viral pathogenicity, replication, and shedding in chickens and pheasants. The close genetic relationship, but obvious differences between PhCoVs and IBVs suggested the IBVs could be the ancestors of PhCoVs, and that PhCoVs isolated from different outbreaks may have evolved independently from IBVs circulating in the specific region by adaption in pheasants. This hypothesis was supported by analysis of the S1 gene fragments of the two PhCoVs isolated in the current study, as well as PhCoVs isolated in the UK and selected IBV strains. Such analyses indicated different evolution patterns and different tissue tropisms between PhCoVs isolated in different outbreaks. Further studies are needed to confirm this hypothesis by studying the complete genomic sequences of PhCoVs from different outbreaks and the pathogenicity of IBVs in pheasants to compare and clarify the relationships between PhCoVs and IBVs. © 2019 Elsevier B.V.",Adaption and evolution; Complete genome; Infectious bronchitis virus; Pheasant coronavirus; S1 gene,animal experiment; antibody response; antigenicity; article; Avian infectious bronchitis virus; chick embryo; chicken; China; controlled study; embryo; genome analysis; molecular phylogeny; nonhuman; pathogenicity; Phasianus colchicus; tropism; virus particle; virus strain,"Archetti, I., Horsfall, F.L.J., Persistent antigenic variation of influenza A viruses after incomplete neutralization in ovo with heterologous immune serum (1950) J. Exp. 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Virol., 86, pp. 719-725; Liu, S., Kong, X., A new genotype of nephropathogenic infectious bronchitis virus circulating in vaccinated and non-vaccinated flocks in China (2004) Avian Pathol., 33, pp. 321-327; Liu, S., Wang, Y., Ma, Y., Han, Z., Zhang, Q., Shao, Y., Chen, J., Kong, X., Identification of a newly isolated avian infectious bronchitis coronavirus variant in China exhibiting affinity for the respiratory tract (2008) Avian Dis., 52, pp. 306-314; Liu, S., Zhang, Q., Chen, J., Han, Z., Shao, Y., Kong, X., Tong, G., Identification of the avian infectious bronchitis coronaviruses with mutations in gene 3 (2008) Gene, 412, pp. 12-25; Liu, S., Zhang, X., Gong, L., Yan, B., Li, C., Han, Z., Shao, Y., Kong, X., Altered pathogenicity, immunogenicity, tissue tropism and 3’-7kb region sequence of an avian infectious bronchitis coronavirus strain after serial passage in embryos (2009) Vaccine, 27, pp. 4630-4640; Liu, X., Ma, H., Xu, Q., Sun, N., Han, Z., Sun, C., Guo, H., Liu, S., Characterization of a recombinant coronavirus infectious bronchitis virus with distinct S1 subunits of spike and nucleocapsid genes and a 3’ untranslated region (2013) Vet. 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Evol., 39, pp. 349-364; Woo, P.C., Lau, S.K., Lam, C.S., Tsang, A.K., Hui, S.W., Fan, R.Y., Martelli, P., Yuen, K.Y., Discovery of a novel bottlenose dolphin coronavirus reveals a distinct species of marine mammal coronavirus in Gammacoronavirus (2014) J.Virol., 88, pp. 1318-1331; Zhao, W., Gao, M., Xu, Q., Xu, Y., Zhao, Y., Chen, Y., Zhang, T., Liu, S., Origin and evolution of LX4 genotype infectious bronchitis coronavirus in China (2017) Vet. Microbiol., 198, pp. 9-16; Ziebuhr, J., The coronavirus replicase (2005) Curr. Top. Microbiol. Immunol., 287, pp. 57-94","Liu, S.; Division of Avian Infectious Diseases, National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, the Chinese Academy of Agricultural SciencesChina; email: liushengwang@caas.cn",,Elsevier B.V.,3781135,,VMICD,31902509,English,Vet. Microbiol.,Article,Final,Open Access,Scopus,2-s2.0-85075552311,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Chung M., Bernheim A., Mei X., Zhang N., Huang M., Zeng X., Cui J., Xu W., Yang Y., Fayad Z.A., Jacobi A., Li K., Li S., Shan H.",57193933823;56492467000;57215863828;56216183600;57215863683;57215863636;26030302300;57215821622;57216113499;7006629064;16425960000;57212136670;57211730184;7101618077;,CT imaging features of 2019 novel coronavirus (2019-NCoV),2020,Radiology,295,1,,202,207,,27,10.1148/radiol.2020200230,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081380582&doi=10.1148%2fradiol.2020200230&partnerID=40&md5=ea5c47f80988f947d59da674716aeace,"Department of Diagnostic, Molecular, and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States; BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Department of Radiology, First Affiliated Hospital of Nanchang University, Nanchang, China; Department of Radiology, Affiliated Hospital of Qingdao University, Qingdao, China; Guangdong Provincial Key Laboratory of Biomedical Imaging, Department of Radiology, Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Rd, New Xiangzhou, Zhuhai, Guangdong Province, 519000, China","Chung, M., Department of Diagnostic, Molecular, and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Bernheim, A., Department of Diagnostic, Molecular, and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Mei, X., BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Zhang, N., Department of Radiology, First Affiliated Hospital of Nanchang University, Nanchang, China; Huang, M., Department of Diagnostic, Molecular, and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Zeng, X., Department of Radiology, First Affiliated Hospital of Nanchang University, Nanchang, China; Cui, J., Department of Radiology, Affiliated Hospital of Qingdao University, Qingdao, China; Xu, W., Department of Radiology, Affiliated Hospital of Qingdao University, Qingdao, China; Yang, Y., BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Fayad, Z.A., Department of Diagnostic, Molecular, and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Jacobi, A., Department of Diagnostic, Molecular, and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Li, K., Guangdong Provincial Key Laboratory of Biomedical Imaging, Department of Radiology, Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Rd, New Xiangzhou, Zhuhai, Guangdong Province, 519000, China; Li, S., Guangdong Provincial Key Laboratory of Biomedical Imaging, Department of Radiology, Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Rd, New Xiangzhou, Zhuhai, Guangdong Province, 519000, China; Shan, H., Guangdong Provincial Key Laboratory of Biomedical Imaging, Department of Radiology, Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Rd, New Xiangzhou, Zhuhai, Guangdong Province, 519000, China","In this retrospective case series, chest CT scans of 21 symptomatic patients from China infected with the 2019 novel coronavirus (2019-nCoV) were reviewed, with emphasis on identifying and characterizing the most common findings. Typical CT findings included bilateral pulmonary parenchymal ground-glass and consolidative pulmonary opacities, sometimes with a rounded morphology and a peripheral lung distribution. Notably, lung cavitation, discrete pulmonary nodules, pleural effusions, and lymphadenopathy were absent. Follow-up imaging in a subset of patients during the study time window often demonstrated mild or moderate progression of disease, as manifested by increasing extent and density of lung opacities. © RSNA, 2020.",,"adult; aged; Article; bilateral pulmonary parenchymal ground glass opacity; case study; China; clinical article; clinical feature; computer assisted tomography; consolidative pulmonary opacity; Coronavirus disease 2019; Coronavirus infection; disease course; disease severity; female; follow up; human; image analysis; male; priority journal; retrospective study; SARS coronavirus; SARS coronavirus 2; Betacoronavirus; complication; Coronavirus infection; diagnostic imaging; disease exacerbation; isolation and purification; lung; middle aged; pathology; severe acute respiratory syndrome; virus pneumonia; x-ray computed tomography; COVID-19; severe acute respiratory syndrome coronavirus 2; Adult; Aged; Betacoronavirus; Coronavirus Infections; Disease Progression; Female; Humans; Lung; Male; Middle Aged; Pneumonia, Viral; Retrospective Studies; Severe Acute Respiratory Syndrome; Tomography, X-Ray Computed","Novel Coronavirus – China, , https://www.who.int/csr/don/12-january-2020-novel-coronavirus-china/en/, World Health Organization. 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Published April 21; MiddleEastrespiratorysyndromeCoronavirus(MERS-CoV), , https://www.who.int/emergencies/mers-cov/en/, WorldHealth Organization; Situationreport-8, , https://www.who.int/docs/default-source/Coronaviruse/situation-reports/20200128-sitrep-8-ncovcleared.pdf?sfvrsn=8b671ce5_2, Published January 28, 2020; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Lancet, 2020. , Jan 24 Epub ahead of print; Hansell, D.M., Bankier, A.A., MacMahon, H., McLoud, T.C., Müller, N.L., Remy, J., Fleischner society: Glossary of terms for thoracic imaging (2008) Radiology, 246 (3), pp. 697-722; Koo, H.J., Lim, S., Choe, J., Choi, S.H., Sung, H., Do, K.H., Radiographic and CT features of viral pneumonia (2018) RadioGraphics, 38 (3), pp. 719-739; Ooi, G.C., Khong, P.L., Müller, N.L., Severe acute respiratory syndrome: Temporal lung changes at thin-section CT in 30 patients (2004) Radiology, 230 (3), pp. 836-844; Wong, K.T., Antonio, G.E., Hui, D.S., Severe acute respiratory syndrome: Radiographic appearances and pattern of progression in 138 patients (2003) Radiology, 228 (2), pp. 401-406; Ajlan, A.M., Ahyad, R.A., Jamjoom, L.G., Alharthy, A., Madani, T.A., Middle East respiratorysyndromecoronavirus(MERS-CoV)infection:chestCTfindings (2014) AJR Am J Roentgenol, 203 (4), pp. 782-787; Choi, W.J., Lee, K.N., Kang, E.J., Lee, H., Middle East respiratory syndrome-Coronavirus infection: A case report of serial computed tomographic findings in a young Male patient (2016) Korean J Radiol, 17 (1), pp. 166-170; Novel Coronavirus (2019-nCoV), , https://www.cdc.gov/Coronavirus/2019-ncov/about/symptoms.html, About 2019 Centers for Disease Control and Prevention. Updated January 31, 2020; Paul, N.S., Roberts, H., Butany, J., Radiologic pattern of disease in patients with severe acute respiratory syndrome: The Toronto experience (2004) RadioGraphics, 24 (2), pp. 553-563","Shan, H.; Guangdong Provincial Key Laboratory of Biomedical Imaging, Department of Radiology, Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Rd, China; email: Shanhong@mail.sysu.edu.cn",,Radiological Society of North America Inc.,338419,,RADLA,32017661,English,Radiology,Article,Final,Open Access,Scopus,2-s2.0-85081380582,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Soriano V., Barreiro P.",57208312072;7004761120;,Impact of new coronavirus epidemics on HIV-infected patients,2020,AIDS Reviews,22,1,,57,58,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081283505&partnerID=40&md5=969900d323d4c2495b726915409574ed,"UNIR Health Sciences School and Medical Center, Madrid, Spain; Infectious Diseases Department, La Paz University Hospital, Madrid, Spain","Soriano, V., UNIR Health Sciences School and Medical Center, Madrid, Spain; Barreiro, P., Infectious Diseases Department, La Paz University Hospital, Madrid, Spain","Since the first report of a cluster of pneumonia cases in Wuhan (China) at the end of 2019 due to a new airborne highly transmissible coronavirus known as SARS-CoV-2, large-scale spreading has rapidly become a global concern. Up to the end of February 2020, more than 85,000 cases had been confirmed worldwide, mostly in China, with more than 3,000 deaths. Figures are increasing on a daily basis, being unpredictable what will happen next. Table 1 summarizes figures for major outbreaks due to acute viral infections recorded during the past 50 years. © 2020, Publicaciones Permanyer. All rights reserved.",,guanine nucleotide binding protein; virus spike protein; Coronavirus infection; diarrhea; Ebolavirus; epidemic; Hepatitis C virus; human; Human immunodeficiency virus infection; Human respiratory syncytial virus; Influenza A virus (H7N9); Influenza virus; Middle East respiratory syndrome; Middle East respiratory syndrome coronavirus; mixed infection; mortality rate; myelitis; Nipah virus; nonhuman; Note; novel coronavirus 2019; novel coronavirus disease 2019; pneumonia; polymerase chain reaction; reinfection; respiratory tract infection; Rhinovirus; RNA virus; SARS coronavirus; severe acute respiratory syndrome; virus genome; virus load; virus replication; virus transmission; zoonosis,,,,Publicaciones Permanyer,11396121,,ADRVF,32167508,English,AIDS Rev.,Note,Final,,Scopus,2-s2.0-85081283505,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "McCloskey B., Heymann D.L.",7003337281;7103238630;,SARS to novel coronavirus - Old lessons and new lessons,2020,Epidemiology and Infection,,, e22,,,,4,10.1017/S0950268820000254,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078975522&doi=10.1017%2fS0950268820000254&partnerID=40&md5=0f5a743b08824c428cf1b4929c9df22c,"Centre on Global Health Security, Chatham House, Royal Institute of International Affairs, London, United Kingdom; London School of Hygiene and Tropical Medicine, London, United Kingdom","McCloskey, B., Centre on Global Health Security, Chatham House, Royal Institute of International Affairs, London, United Kingdom; Heymann, D.L., London School of Hygiene and Tropical Medicine, London, United Kingdom","The response to the novel coronavirus outbreak in China suggests that many of the lessons from the 2003 SARS epidemic have been implemented and the response improved as a consequence. Nevertheless some questions remain and not all lessons have been successful. The national and international response demonstrates the complex link between public health, science and politics when an outbreak threatens to impact on global economies and reputations. The unprecedented measures implemented in China are a bold attempt to control the outbreak - we need to understand their effectiveness to balance costs and benefits for similar events in the future. Copyright © The Author(s) 2020.",coronavirus; Emerging Infectious Diseases; epidemic Response; lessons learned; novel; outbreak Response; SARS,,"https://www.who.int/emergencies/diseases/novel-coronavirus-2019, Accessed 28 January 2020; https://www.who.int/news-room/detail/23-01-2020-statement-on-the-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-outbreak-of-novel-coronavirus-(2019-ncov), Accessed 28 January 2020; https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200127-sitrep-7-2019-ncov.pdf?sfvrsn=98ef79f5_2, Accessed 28 January 2020; https://promedmail.org/promed-post/?id=20200122.6907971, Accessed 28 January 2020; Read, J.M., Novel coronavirus 2019-nCoV: Early estimation of epidemiological parameters and predictions (2020) MedRxiv, , doi: (Accessed 28/10/2020); Imai, N., https://www.imperial.ac.uk/media/imperial-college/medicine/sph/ide/gida-fellowships/Imperial-2019-nCoV-transmissibility.pdf, Transmissibility of 2019-nCoV; Report from Imperial College London; https://www.who.int/csr/sars/WHOconsensus.pdf?ua=1, Accessed 28 January 2020; https://www.barrons.com/articles/how-chinas-economy-is-taking-a-hit-from-coronavirus-51579882413, (Accessed 28 January 2020) (subscription); http://oneill.law.georgetown.edu/news/who-emergency-committee-under-the-international-health-regulations-to-review-the-ebola-epidemic-in-the-democratic-republic-of-congo/, Accessed 28 January 2020","Mccloskey, B.; Centre on Global Health Security, Chatham House, Royal Institute of International AffairsUnited Kingdom; email: BMcCloskey@chathamhouse.org",,Cambridge University Press,9502688,,EPINE,32019614,English,Epidemiol. Infect.,Review,Article in Press,Open Access,Scopus,2-s2.0-85078975522,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Li B., Si H.-R., Zhu Y., Yang X.-L., Anderson D.E., Shi Z.-L., Wang L.-F., Zhou P.",57077269800;57215134494;55723768200;35811468700;25631949200;7403733955;35243718700;56996599500;,Discovery of bat coronaviruses through surveillance and probe capture-based next-generation sequencing,2020,mSphere,5,1, e00807,,,,,10.1128/mSphere.0807-19,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078689119&doi=10.1128%2fmSphere.0807-19&partnerID=40&md5=c7853c06f8c20bea9ac02023a0dc3280,"CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; University of Chinese Academy of Sciences, Beijing, China; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore","Li, B., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Si, H.-R., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China, University of Chinese Academy of Sciences, Beijing, China; Zhu, Y., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Yang, X.-L., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Anderson, D.E., Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore; Shi, Z.-L., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Wang, L.-F., Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore; Zhou, P., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China","Coronaviruses (CoVs) of bat origin have caused two pandemics in this century. Severe acute respiratory syndrome (SARS)-CoV and Middle East respiratory syndrome (MERS)-CoV both originated from bats, and it is highly likely that bat coronaviruses will cause future outbreaks. Active surveillance is both urgent and essential to predict and mitigate the emergence of these viruses in humans. Next-generation sequencing (NGS) is currently the preferred methodology for virus discovery to ensure unbiased sequencing of bat CoVs, considering their high genetic diversity. However, unbiased NGS is an expensive methodology and is prone to missing low-abundance CoV sequences due to the high background level of nonviral sequences present in surveillance field samples. Here, we employ a capture-based NGS approach using baits targeting most of the CoV species. Using this technology, we effectively reduced sequencing costs by increasing the sensitivity of detection. We discovered nine full genomes of bat CoVs in this study and revealed great genetic diversity for eight of them. IMPORTANCE Active surveillance is both urgent and essential to predict and mitigate the emergence of bat-origin CoV in humans and livestock. However, great genetic diversity increases the chance of homologous recombination among CoVs. Performing targeted PCR, a common practice for many surveillance studies, would not reflect this diversity. NGS, on the other hand, is an expensive methodology and is prone to missing low-abundance CoV sequences. Here, we employ a capture-based NGS approach using baits targeting all CoVs. Our work demonstrates that targeted, cost-effective, large-scale, genome-level surveillance of bat CoVs is now highly feasible. © 2020 Li et al.",Bat; Coronavirus; Enrichment; Genome; Next-generation sequencing,"article; Coronavirinae; genetic variability; high throughput sequencing; homologous recombination; human; livestock; nonhuman; polymerase chain reaction; animal; bat; classification; Coronavirinae; genetic variation; high throughput sequencing; isolation and purification; procedures; virology; virus genome; Animals; Chiroptera; Coronavirus; Genetic Variation; Genome, Viral; High-Throughput Nucleotide Sequencing","Forni, D., Cagliani, R., Clerici, M., Sironi, M., Molecular evolution of human coronavirus genomes (2017) Trends Microbiol, 25, pp. 35-48. , https://doi.org/10.1016/j.tim.2016.09.001; Woo, P.C., Lau, S.K., Huang, Y., Yuen, K.Y., Coronavirus diversity, phylog-eny and interspecies jumping (2009) Exp Biol Med (Maywood), 234, pp. 1117-1127. , https://doi.org/10.3181/0903-MR-94; 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Wang, L.-F., Cowled, C., (2015) Bats and viruses: A new frontier of emerging infectious diseases, , John Wiley & Sons, Inc, Hoboken, NJ; Fan, Y., Zhao, K., Shi, Z.L., Zhou, P., Bat coronaviruses in China (2019) Viruses, 11, p. 210. , https://doi.org/10.3390/v11030210; Carroll, D., Daszak, P., Wolfe, N.D., Gao, G.F., Morel, C.M., Morzaria, S., Pablos-Mendez, A., Mazet, J., The Global Virome Project (2018) Science, 359, pp. 872-874. , https://doi.org/10.1126/science.aap7463; Briese, T., Kapoor, A., Mishra, N., Jain, K., Kumar, A., Jabado, O.J., Lipkin, W.I., Virome capture sequencing enables sensitive viral diagnosis and comprehensive virome analysis (2015) MBio, 6. , https://doi.org/10.1128/mBio.01491-15; Gaudin, M., Desnues, C., Hybrid capture-based next generation sequencing and its application to human infectious diseases (2018) Front Microbiol, 9, p. 2924. , https://doi.org/10.3389/fmicb.2018.02924; Wylie, T.N., Wylie, K.M., Herter, B.N., Storch, G.A., Enhanced virome sequencing using targeted sequence capture (2015) Genome Res, 25, pp. 1910-1920. , https://doi.org/10.1101/gr.191049.115; Lim, X.F., Lee, C.B., Pascoe, S.M., How, C.B., Chan, S., Tan, J.H., Yang, X., Yap, G., Detection and characterization of a novel bat-borne coronavirus in Singapore using multiple molecular approaches (2019) J Gen Virol, 100, pp. 1363-1374. , https://doi.org/10.1099/jgv.0.001307; Noyes, N.R., Weinroth, M.E., Parker, J.K., Dean, C.J., Lakin, S.M., Raymond, R.A., Rovira, P., Morley, P.S., Enrichment allows identification of diverse, rare elements in metagenomic resistome-virulome sequencing (2017) Microbiome, 5, p. 142. , https://doi.org/10.1186/s40168-017-0361-8; Metsky, H.C., Siddle, K.J., Gladden-Young, A., Qu, J., Yang, D.K., Brehio, P., Goldfarb, A., Matranga, C.B., Capturing sequence diversity in metagenomes with comprehensive and scalable probe design (2019) Nat Biotechnol, 37, pp. 160-168. , https://doi.org/10.1038/s41587-018-0006-x; Lau, S.K., Woo, P.C., Li, K.S., Huang, Y., Wang, M., Lam, C.S., Xu, H., Yuen, K.Y., Complete genome sequence of bat corona-virus HKU2 from Chinese horseshoe bats revealed a much smaller spike gene with a different evolutionary lineage from the rest ofthe genome (2007) Virology, 367, pp. 428-439. , https://doi.org/10.1016/j.virol.2007.06.009; Zhang, W., Zheng, X.S., Agwanda, B., Ommeh, S., Zhao, K., Lichoti, J., Wang, N., Shi, Z.L., Serological evidence of MERS-CoV and HKU8-related CoV co-infection in Kenyan camels (2019) Emerg Microbes Infect, 8, pp. 1528-1534. , https://doi.org/10.1080/22221751.2019.1679610; Luo, C.-M., Wang, N., Yang, X.-L., Liu, H.-Z., Zhang, W., Li, B., Hu, B., Shi, Z.-L., Discovery of novel bat coronaviruses in South China that use the same receptor as Middle East respiratory syndrome coronavirus (2018) J Virol, 92. , https://doi.org/10.1128/JVI.00116-18; Ge, X.Y., Wang, N., Zhang, W., Hu, B., Li, B., Zhang, Y.Z., Zhou, J.H., Shi, Z.L., Coexistence of multiple coronaviruses in several bat colonies in an abandoned mineshaft (2016) Virol Sin, 31, pp. 31-40. , https://doi.org/10.1007/s12250-016-3713-9; Goecks, J., Nekrutenko, A., Taylor, J., Galaxy: A comprehensive approach for supporting accessible, reproducible, and transparent computational research in the life sciences (2010) Genome Biol, 11, p. R86. , https://doi.org/10.1186/gb-2010-11-8-r86","Wang, L.-F.; Programme in Emerging Infectious Diseases, Duke-NUS Medical SchoolSingapore; email: linfa.wang@duke-nus.edu.sg",,American Society for Microbiology,23795042,,,31996413,English,mSphere,Article,Final,,Scopus,2-s2.0-85078689119,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Li T.,55776190500;,"Diagnosis and clinical management of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection: an operational recommendation of Peking Union Medical College Hospital (V2.0): Working Group of 2019 Novel Coronavirus, Peking Union Medical College Hospital",2020,Emerging Microbes and Infections,9,1,,582,585,,,10.1080/22221751.2020.1735265,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081884656&doi=10.1080%2f22221751.2020.1735265&partnerID=40&md5=722b1d22453e83b52fe240b4ad10b244,"Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China","Li, T., Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China","Since December 2019, China has been experiencing an outbreak of a new infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The clinical features include fever, coughing, shortness of breath, and inflammatory lung infiltration. China rapidly listed SARS-CoV-2-related pneumonia as a statutory infectious disease. To standardize the diagnosis and treatment of this new infectious disease, an operational recommendation for the diagnosis and management of SARS-CoV-2 infection is developed by Peking Union Medical College Hospital. © 2020, © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd.",Coronavirus disease 2019; diagnosis; pneumonia; SARS-CoV-2; treatment,"antibiotic agent; glucocorticoid; immunoglobulin; COVID-19; antimicrobial therapy; antiviral therapy; assisted ventilation; Betacoronavirus; coronavirus disease 2019; Coronavirus infection; corticosteroid therapy; critically ill patient; human; infection prevention; isolation; medical personnel; nonhuman; oxygen therapy; priority journal; Review; screening; severe acute respiratory syndrome coronavirus 2; Coronavirus infection; health care personnel; hospital; occupational exposure; patient isolation; practice guideline; virus pneumonia; Coronavirus Infections; Health Personnel; Hospitals; Humans; Occupational Exposure; Patient Isolation; Pneumonia, Viral; Practice Guidelines as Topic","http://www.nhc.gov.cn/xcs/zhengcwj/202001/f492c9153ea9437bb587ce2ffcbee1fa/files/39e7578d85964dbe81117736dd789d8f.pdf, The guidelines for the diagis and treatment of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection (Pilot 3rd version) [S/OL].(2020-01-22)[2020-01-22]. Available from; https://www.who.int/docs/default-source/coronaviruse/clinical-management-of-novel-cov.pdf?sfvrsn=bc7da517_2%26download=true, Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected: interim guidance[S/OL]. (2020-01-12)[2020-01-22]. Available from; Li, T., Qiu, Z., Han, Y., Rapid loss of both CD4+ and CD8+ T lymphocyte subsets during the acute phase of severe acute respiratory syndrome (2003) Chin Med J (Engl), 116 (7), pp. 985-987; Tai-sheng, L.I., Zhi-feng, Q.I.U., Yang, H.A.N., The alterations of T cell subsets of severe acute respiratory syndrome during acute phase (2003) Chin J Lab Med, 26 (5), pp. 297-299; Taoran, G., Yang, H., Taisheng, L., Characteristics and prognostic value of peripheral blood T lymphocyte subsets in patients with severe influenza (2020) Chin J Internal Med, 59 (3). , https://doi.org/10.3760/cma.j.issn.0578-1426.2020.03; Mori, I., Parizot, C., Dorgham, K., Prominent plasmacytosis following intravenous immunoglobulin correlates with clinical improvement in Guillain–Barré syndrome (2008) PLoS One, 3 (5). , https://doi.org/10.1371/journal.pone.0002109; Hemming, V.G., Use of intravenous immunoglobulins for prophylaxis or treatment of infectious diseases (2001) Clin Diagn Lab Immunol, 8 (5), pp. 859-863. , https://doi.org/10.1128/CDLI.8.5.859-863.2001","Li, T.; Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina; email: litsh@263.net",,Taylor and Francis Ltd.,22221751,,,32172669,English,Emerg. Microbes Infect.,Review,Final,Open Access,Scopus,2-s2.0-85081884656,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhang J., Wang S., Xue Y.",57203863381;57215717434;57215715327;,Fecal specimen diagnosis 2019 novel coronavirus–infected pneumonia,2020,Journal of Medical Virology,,,,,,,,10.1002/jmv.25742,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081722616&doi=10.1002%2fjmv.25742&partnerID=40&md5=29fbd3f47b97933531731a2cf450b403,"Department of Respiration, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua, China","Zhang, J., Department of Respiration, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua, China; Wang, S., Department of Respiration, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua, China; Xue, Y., Department of Respiration, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua, China","The emergence and spread of 2019 novel coronavirus–infected pneumonia (COVID-19) from Wuhan, China, it has spread globally. We extracted the data on 14 patients with laboratory-confirmed COVID-19 from Jinhua Municipal Central hospital through 27 January 2020. We found that compared to pharyngeal swab specimens, nucleic acid detection of COVID-19 in fecal specimens was equally accurate. And we found that patients with a positive stool test did not experience gastrointestinal symptoms and had nothing to do with the severity of the lung infection. These results may help to understand the clinical diagnosis and the changes in clinical parameters of COVID-19. © 2020 Wiley Periodicals, Inc.",coronavirus; dissemination; nervous system; pathogenesis; virus classification,,"Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumoniain China (2020) N Engl J Med, 382, pp. 727-733; http://www.nhc.gov.cn/xcs/yqfkdt/202002/945bd98a9d884aeeb54d76afa02ca813.shtml, Accessed on 25 February 2020; Novel coronavirus(2019-nCoV): situation report-36, , https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200225-sitrep-36-covid-19.pdf?sfvrsn=2791b4e0_2, Accessed 25 February 2020; Wang, D., Hu, B., Hu, C., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China (2020) JAMA, , https://doi.org/10.1001/jama.2020.1585; Zhou, P., Yang, X.L., Wang, X.G., Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin (2020) Nature, , https://doi.org/10.1038/s41586-020-2012-7; Shi, X., Gong, E., Gao, D., Severe acute respiratory syndrome associated coronavirus is detected in intestinal tissues of fatal cases (2005) Am J Gastroenterol, 100 (1), pp. 169-176; Ding, Y., He, L., Zhang, Q., Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways (2004) J Pathol, 203 (2), pp. 622-630; Zhang, Y., Chen, H., Zhu, S., Isolation of 2019-nCoV from a stool specimen of a laboratory-confirmed case of the coronavirus disease 2019 (COVID-19) (2020) China CDC Weekly, 2 (8), pp. 123-124; Guan, W., Ni, Z., Hu, Y., Clinical characteristics of 2019 novel coronavirus infection in China (2020) N Engl J Med, , https://doi.org/10.1056/NEJMoa2002032; Zhang, H., Kang, Z., Gong, H., (2020) The digestive system is a potential route of 2019-nCov infection: a bioinformatics analysis based on single-cell transcriptomes, , https://www.biorxiv.org/content/10.1101/2020.01.30.927806v1, Preprint at; Zhang, W., Du, R.H., Li, B., Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes (2020) Emerging Microbes Infect, 9, pp. 386-389","Zhang, J.; Department of Respiration, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang UniversityChina; email: zjc1983@126.com",,John Wiley and Sons Inc.,1466615,,JMVID,32124995,English,J. Med. Virol.,Article,Article in Press,Open Access,Scopus,2-s2.0-85081722616,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, [No author name available],[No author id available],"Correction to: Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan (Emerging Microbes & Infections, (2020), 9, 1, (221-236), 10.1080/22221751.2020.1719902)",2020,Emerging Microbes and Infections,9,1,,540,,,,10.1080/22221751.2020.1737364,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081043117&doi=10.1080%2f22221751.2020.1737364&partnerID=40&md5=5e9075a6fda5c907f4f803c1bb97bc3b,,,"Article title: Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan Authors: Chan, J. F-W., Kok, K-H., Zhu, Z., Chu, H., To K. K-W., Yuan, S., & Yuen, K-Y. Journal:Emerging Microbes & InfectionsBibliometrics: Volume 9, Number 1, pages 221 –236 DOI: https://doi.org/10.1080/22221751.2020.1719902 When the article was first published online, Figure 1 and its caption were wrong. This has now been corrected in online version. © 2020, © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd.",,erratum,,,,Taylor and Francis Ltd.,22221751,,,32133926,English,Emerg. Microbes Infect.,Erratum,Final,Open Access,Scopus,2-s2.0-85081043117,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Cheng V.C.C., Wong S.-C., Chen J.H.K., Yip C.C.Y., Chuang V.W.M., Tsang O.T.Y., Sridhar S., Chan J.F.W., Ho P.-L., Yuen K.-Y.",23670479400;57193077353;35085819900;57211316864;11638887500;6602450830;55845494300;24278817900;7402211363;57216110275;,Escalating infection control response to the rapidly evolving epidemiology of the Coronavirus disease 2019 (COVID-19) due to SARS-CoV-2 in Hong Kong,2020,Infection Control and Hospital Epidemiology,,,,,,,1,10.1017/ice.2020.58,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082084785&doi=10.1017%2fice.2020.58&partnerID=40&md5=5a8421e3e69e27dc73dd31e66eb2383a,"Department of Microbiology, Queen Mary Hospital, Hong Kong; Infection Control Team, Queen Mary Hospital, Hong Kong; Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong; Quality and Safety Division, Hospital Authority, Hong Kong; Infectious Disease Center, Hospital Authority, Hong Kong","Cheng, V.C.C., Department of Microbiology, Queen Mary Hospital, Hong Kong, Infection Control Team, Queen Mary Hospital, Hong Kong; Wong, S.-C., Infection Control Team, Queen Mary Hospital, Hong Kong; Chen, J.H.K., Department of Microbiology, Queen Mary Hospital, Hong Kong; Yip, C.C.Y., Department of Microbiology, Queen Mary Hospital, Hong Kong; Chuang, V.W.M., Quality and Safety Division, Hospital Authority, Hong Kong; Tsang, O.T.Y., Infectious Disease Center, Hospital Authority, Hong Kong; Sridhar, S., Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong; Chan, J.F.W., Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong; Ho, P.-L., Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong; Yuen, K.-Y., Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong","Background:To describe the infection control preparedness for Coronavirus Disease (COVID-19) due to SARS-CoV-2 [previously known as 2019-novel coronavirus] in the first 42 days after announcement of a cluster of pneumonia in China, on 31 December 2019 (day 1) in Hong Kong.Methods:A bundle approach of active and enhanced laboratory surveillance, early airborne infection isolation, rapid molecular diagnostic testing, and contact tracing for healthcare workers (HCWs) with unprotected exposure in the hospitals was implemented. Epidemiological characteristics of confirmed cases, environmental and air samples were collected and analyzed.Results:From day 1 to day 42, forty-two (3.3%) of 1275 patients fulfilling active (n=29) and enhanced laboratory surveillance (n=13) confirmed to have SARS-CoV-2 infection. The number of locally acquired case significantly increased from 1 (7.7%) of 13 [day 22 to day 32] to 27 (93.1%) of 29 confirmed case [day 33 to day 42] (p<0.001). Twenty-eight patients (66.6%) came from 8 family clusters. Eleven (2.7%) of 413 HCWs caring these confirmed cases were found to have unprotected exposure requiring quarantine for 14 days. None of them was infected and nosocomial transmission of SARS-CoV-2 was not observed. Environmental surveillance performed in a patient with viral load of 3.3x106 copies/ml (pooled nasopharyngeal/ throat swab) and 5.9x106 copies/ml (saliva) respectively. SARS-CoV-2 revealed in 1 (7.7%) of 13 environmental samples, but not in 8 air samples collected at a distance of 10 cm from patient's chin with or without wearing a surgical mask.Conclusion:Appropriate hospital infection control measures could prevent nosocomial transmission of SARS-CoV-2. © 2020 by The Society for Healthcare Epidemiology of America. All rights reserved.",,,"Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in china, 2019 N Engl J Med Jan, 24, p. 2020; Novel Coronavirus (2019-nCoV) Situation report-1, , http://www.who.int/docs/default-source/coronaviruse/situation-reports/20200121-sitrep-1-2019-ncov.pdfsfvrsn=20a99c104, World Health Organization, (Accessed at 10 Feburary 2020); Cheng, V.C., Lau, S.K., Woo, P.C., Yuen, K.Y., Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection (2007) Clin Microbiol Rev, 20, pp. 660-694; Cheng, V.C., Chan, J.F., To, K.K., Yuen, K.Y., Clinical management and infection control of SARS: Lessons learned (2013) Antiviral Res, 100, pp. 407-419; Chan, J.F., Lau, S.K., To, K.K., Cheng, V.C., Woo, P.C., Yuen, K.Y., Middle East respiratory syndrome coronavirus: Another zoonotic betacoronavirus causing SARS-like disease (2015) Clin Microbiol Rev, 28, pp. 465-522; Coronavirus Disease 2019 (COVID-19) Situation report-28, , http://www.who.int/docs/default-source/coronaviruse/situation-reports/20200217-sitrep-28-covid-19.pdfsfvrsn=a19cf2ad2, World Health Organization, Accessed at 19 Feburary 2020; Wong, A.T.Y., Chen, H., Liu, S.H., From SARS to Avian Influenza Preparedness in Hong Kong (2017) Clin Infect Dis, 64, pp. S98-S104; Cheng, V.C.C., Wong, S.C., To, K.K.W., Ho, P.L., Yuen, K.Y., Preparedness and proactive infection control measures against the emerging novel coronavirus in China (2020) J Hosp Infect Jan, 18; Cheng, V.C., Tai, J.W., Lee, W.M., Infection control preparedness for human infection with influenza A H7N9 in Hong Kong (2015) Infect Control Hosp Epidemiol, 36, pp. 87-92; Yip, C.C., Lam, C.S., Luk, H.K., A six-year descriptive epidemiological study of human coronavirus infections in hospitalized patients in Hong Kong (2016) Virol Sin, 31, pp. 41-48; Chan, J.F.W., Yip, C.C.Y., To, K.K.W., Improved molecular diagnosis of Covid-19 by the novel, highly sensitive and specific Covid-19-RdRp/Hel real-time reverse transcription-polymerase chain reaction assay validated in vitro and with clinical specimens J Clin Microbiol, , provisionally accepted; Cheng, V.C.C., Wong, S.C., Chiu, K.H.Y., Yip, C.C.Y., Wong, S.C.Y., Yuen, K.Y., Detection of norovirus in air samples in a non-vomiting patient: Implications of testing saliva for norovirus in an immunocompromised host (2019) J Hosp Infect, 103, pp. 357-358; Cheng, V.C.C., Wong, S.C., Wong, S.C.Y., Measles outbreak from Hong Kong International Airport to the hospital due to secondary vaccine failure in healthcare workers (2019) Infect Control Hosp Epidemiol, 40, pp. 1407-1415; Wu, J., Xu, F., Zhou, W., Risk factors for SARS among persons without known contact with SARS patients, Beijing, China (2004) Emerg Infect Dis, 10, pp. 210-216; Loeb, M., McGeer, A., Henry, B., SARS among critical care nurses (2004) Toronto. Emerg Infect Dis, 10, pp. 251-255; Cheng, V.C., Tai, J.W., Wong, L.M., Prevention of nosocomial transmission of swine-origin pandemic influenza virus A/H1N1 by infection control bundle (2010) J Hosp Infect, 74, pp. 271-277; Cheng, V.C., To, K.K., Tse, H., Hung, I.F., Yuen, K.Y., Two years after pandemic influenza A/2009/H1N1: What have we learned (2012) Clin Microbiol Rev, 25, pp. 223-263; Wong, V.W., Cowling, B.J., Aiello, A.E., Hand hygiene and risk of influenza virus infections in the community: A systematic review and meta-analysis (2014) Epidemiol Infect, 142, pp. 922-932; Cheng, V.C., Tai, J.W., Li, W.S., Implementation of directly observed patient hand hygiene for hospitalized patients by hand hygiene ambassadors in Hong Kong (2016) Am J Infect Control, 44, pp. 621-624; Cheng, V.C.C., Wong, S.C., Wong, S.C.Y., Yuen, K.Y., Directly observed hand hygiene-from healthcare workers to patients (2019) J Hosp Infect, 101, pp. 380-382; Roy, C.J., Milton, D.K., Airborne transmission of communicable infection-the elusive pathway (2004) N Engl J Med, 350, pp. 1710-1712; Infection Prevention and Control during Health Care When Novel Coronavirus (NCoV) Infection Is Suspected, , http://www.who.int/publications-detail/infection-prevention-and-control-during-health-care-when-novel-coronavirus-(ncov)-infection-is-suspected-20200125, World Health Organization, (accessed at 10 Feburary 2020); Chan, K.H., Peiris, J.S., Lam, S.Y., Poon, L.L., Yuen, K.Y., Seto, W.H., The effects of temperature and relative humidity on the viability of the sars coronavirus (2011) Adv Virol, 2011, p. 734690; To, K.K.W., Tsang, O.T.Y.Y.C., Chan, K.H., Consistent detection of 2019 novel coronavirus in saliva (2020) Clin Infect Dis, , accepted and in press; Chan, J.F., Yuan, S., Kok, K.H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: A study of a family cluster (2020) Lancet Jan, 24; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan (2020) China. Lancet Jan, 24; Phan, L.T., Nguyen, T.V., Luong, Q.C., Importation and human-to-human transmission of a novel coronavirus in vietnam N Engl J Med Jan, 28, p. 2020; Ren, L.L., Wang, Y.M., Wu, Z.Q., Identification of a novel coronavirus causing severe pneumonia in human: A descriptive study (2020) Chin Med J (Engl), 30. , Jan; Holshue, M.L., DeBolt, C., Lindquist, S., First case of 2019 novel coronavirus in the united states (2020) N Engl J Med Jan, 31; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan (2020) China: A Descriptive Study. Lancet Jan, 30","Yuen, K.-Y.; Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong KongHong Kong; email: kyyuen@hku.hk*MD",,Cambridge University Press,0899823X,,ICEPE,32131908,English,Infect. Control Hosp. Epidemiol.,Article,Article in Press,Open Access,Scopus,2-s2.0-85082084785,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Ghinai I., McPherson T.D., Hunter J.C., Kirking H.L., Christiansen D., Joshi K., Rubin R., Morales-Estrada S., Black S.R., Pacilli M., Fricchione M.J., Chugh R.K., Walblay K.A., Ahmed N.S., Stoecker W.C., Hasan N.F., Burdsall D.P., Reese H.E., Wallace M., Wang C., Moeller D., Korpics J., Novosad S.A., Benowitz I., Jacobs M.W., Dasari V.S., Patel M.T., Kauerauf J., Charles E.M., Ezike N.O., Chu V., Midgley C.M., Rolfes M.A., Gerber S.I., Lu X., Lindstrom S., Verani J.R., Layden J.E.",57212449100;57216009898;55988616700;34874964500;57196543924;57196761907;57193522058;57215770454;38460934200;56376977400;55361974500;56689619200;57202329465;57215778922;57215769787;57215774853;56502229700;57215770199;57214239916;57215770648;57215778241;57215776872;57215780671;36662007800;57215770482;57215778011;57193407153;56744724200;57215775627;9843076700;57215780607;57215984278;57212275884;56656063700;57216109714;57215781165;16041147500;57215771175;,First known person-to-person transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the USA,2020,The Lancet,395,10230,,1137,1144,,,10.1016/S0140-6736(20)30607-3,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081935465&doi=10.1016%2fS0140-6736%2820%2930607-3&partnerID=40&md5=75c02315ed9aebdbfb7abec1bb6fd9a9,"Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA, United States; Division of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States; Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States; Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States; Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States; One Health Office, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States; Illinois Department of Public Health, Springfield, IL, United States; Chicago Department of Public Health, Chicago, IL, United States; Cook County Department of Public Health, Oak Forest, IL, United States; DuPage County Health Department, Wheaton, IL, United States; Metro Infectious Disease Consultants, Burr Ridge, IL, United States; Premier Primary Care Physicians, Carol Stream, IL, United States; Cook County Health, Chicago, IL, United States; Feinberg School of Medicine, Northwestern University, Chicago, IL, United States; Lake Erie College of Osteopathic Medicine, Erie, PA, United States; Boonshoft School of Medicine, Wright State University, Dayton, OH, United States","Ghinai, I., Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA, United States, Illinois Department of Public Health, Springfield, IL, United States; McPherson, T.D., Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA, United States, Chicago Department of Public Health, Chicago, IL, United States; Hunter, J.C., Division of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States; Kirking, H.L., Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States; Christiansen, D., Cook County Department of Public Health, Oak Forest, IL, United States; Joshi, K., Cook County Department of Public Health, Oak Forest, IL, United States; Rubin, R., Cook County Department of Public Health, Oak Forest, IL, United States; Morales-Estrada, S., Cook County Department of Public Health, Oak Forest, IL, United States; Black, S.R., Chicago Department of Public Health, Chicago, IL, United States; Pacilli, M., Chicago Department of Public Health, Chicago, IL, United States; Fricchione, M.J., Chicago Department of Public Health, Chicago, IL, United States; Chugh, R.K., DuPage County Health Department, Wheaton, IL, United States; Walblay, K.A., Chicago Department of Public Health, Chicago, IL, United States; Ahmed, N.S., Metro Infectious Disease Consultants, Burr Ridge, IL, United States; Stoecker, W.C., Metro Infectious Disease Consultants, Burr Ridge, IL, United States; Hasan, N.F., Premier Primary Care Physicians, Carol Stream, IL, United States; Burdsall, D.P., Illinois Department of Public Health, Springfield, IL, United States; Reese, H.E., Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA, United States, Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States; Wallace, M., Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA, United States, Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States; Wang, C., Cook County Health, Chicago, IL, United States, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States; Moeller, D., Cook County Health, Chicago, IL, United States, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States; Korpics, J., Cook County Health, Chicago, IL, United States, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States; Novosad, S.A., Division of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States; Benowitz, I., Division of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States; Jacobs, M.W., Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States, Lake Erie College of Osteopathic Medicine, Erie, PA, United States; Dasari, V.S., One Health Office, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States, Boonshoft School of Medicine, Wright State University, Dayton, OH, United States; Patel, M.T., Illinois Department of Public Health, Springfield, IL, United States; Kauerauf, J., Illinois Department of Public Health, Springfield, IL, United States; Charles, E.M., Illinois Department of Public Health, Springfield, IL, United States; Ezike, N.O., Illinois Department of Public Health, Springfield, IL, United States; Chu, V., Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA, United States, Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States; Midgley, C.M., Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States; Rolfes, M.A., Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States; Gerber, S.I., Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States; Lu, X., Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States; Lindstrom, S., Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States; Verani, J.R., Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States; Layden, J.E., Chicago Department of Public Health, Chicago, IL, United States","Background: Coronavirus disease 2019 (COVID-19) is a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first detected in China in December, 2019. In January, 2020, state, local, and federal public health agencies investigated the first case of COVID-19 in Illinois, USA. Methods: Patients with confirmed COVID-19 were defined as those with a positive SARS-CoV-2 test. Contacts were people with exposure to a patient with COVID-19 on or after the patient's symptom onset date. Contacts underwent active symptom monitoring for 14 days following their last exposure. Contacts who developed fever, cough, or shortness of breath became persons under investigation and were tested for SARS-CoV-2. A convenience sample of 32 asymptomatic health-care personnel contacts were also tested. Findings: Patient 1—a woman in her 60s—returned from China in mid-January, 2020. One week later, she was hospitalised with pneumonia and tested positive for SARS-CoV-2. Her husband (Patient 2) did not travel but had frequent close contact with his wife. He was admitted 8 days later and tested positive for SARS-CoV-2. Overall, 372 contacts of both cases were identified; 347 underwent active symptom monitoring, including 152 community contacts and 195 health-care personnel. Of monitored contacts, 43 became persons under investigation, in addition to Patient 2. These 43 persons under investigation and all 32 asymptomatic health-care personnel tested negative for SARS-CoV-2. Interpretation: Person-to-person transmission of SARS-CoV-2 occurred between two people with prolonged, unprotected exposure while Patient 1 was symptomatic. Despite active symptom monitoring and testing of symptomatic and some asymptomatic contacts, no further transmission was detected. Funding: None. © 2020 Elsevier Ltd",,,"Coronavirus disease (COVID-19) outbreak (2020), https://www.who.int/emergencies/diseases/novel-coronavirus-2019, World Health Organization (Accessed 12 February 2020); Locations with confirmed COVID-19 cases, global map (2020), https://www.cdc.gov/coronavirus/2019-ncov/locations-confirmed-cases.html#map, Centers for Disease Control and Prevention (Accessed 12 February 2020); Lu, R., Zhao, X., Li, J., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet, 395, pp. 565-574; Chan, J.F.-W., Yuan, S., Kok, K.-H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, 395, pp. 514-523; Phan, L., Nguyen, T., Luong, Q., Importation and human-to-human transmission of a novel coronavirus in Vietnam (2020) N Engl J Med, 382, pp. 872-874; Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med, , published online Jan 29; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395, pp. 507-513; Statement on the meeting of the International Health Regulations (2005) Emergency Committee regarding the outbreak of novel coronavirus (2019-nCoV) (2020), https://www.who.int/news-room/detail/23-01-2020-statement-on-the-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-outbreak-of-novel-coronavirus-(2019-ncov), World Health Organization (Accessed 12 February 2020); Park, S.W., Bolker, B.M., Champredon, D., Reconciling early-outbreak estimates of the basic reproductive number and its uncertainty: framework and applications to the novel coronavirus (2019-nCoV) outbreak (2020) medRxiv, , published online Feb 7. (preprint); Interim U.S. guidance for risk assessment and public health management of healthcare personnel with potential exposure in a healthcare setting to patients with 2019 novel coronavirus (2019-nCoV) (2020), https://www.cdc.gov/coronavirus/2019-ncov/hcp/guidance-risk-assesment-hcp.html, Centers for Disease Control and Prevention (Accessed 12 February 2020); Interim US guidance for risk assessment and public health management of persons with potential 2019 novel coronavirus (2019-nCoV) exposure in travel-associated or community settings (2020), https://www.cdc.gov/coronavirus/2019-ncov/php/risk-assessment.html, Centers for Disease Control and Prevention (Accessed 12 February 2020); Appendix 2. Terminology. Infection control in healthcare personnel: infrastructure and routine practices for occupational infection prevention and control services (2019) (2019), https://www.cdc.gov/infectioncontrol/guidelines/healthcare-personnel/appendix/terminology.html, Centers for Disease Control and Prevention (Accessed 17 February 2020); Health alert network: update and interim guidance on outbreak of 2019 novel coronavirus (2019-nCoV) (2020), https://emergency.cdc.gov/han/han00427.asp, Centers for Disease Control and Prevention (Accessed 12 February 2020); Interim guidelines for collecting, handling, and testing clinical specimens from persons under investigation (PUIs) for 2019 novel coronavirus (2019-nCoV) (2020), https://www.cdc.gov/coronavirus/2019-ncov/lab/guidelines-clinical-specimens.html, Centers for Disease Control and Prevention (Accessed 12 February 2020); Research use only real-time RT-PCR protocol for identification of 2019-nCoV (2020), https://www.cdc.gov/coronavirus/2019-ncov/lab/rt-pcr-detection-instructions.html, Centers for Disease Control and Prevention (Accessed 12 February 2020); Infection control basics (2016), https://www.cdc.gov/infectioncontrol/basics/index.html, Centers for Disease Control and Prevention (Accessed 19 February 2020); Chowell, G., Abdirizak, F., Lee, S., Transmission characteristics of MERS and SARS in the healthcare setting: a comparative study (2015) BMC Med, 13, p. 210; Cowling, B.J., Park, M., Fang, V.J., Wu, P., Leung, G.M., Wu, J.T., Preliminary epidemiologic assessment of MERS-CoV outbreak in South Korea, May–June 2015 (2015) Euro Surveill, 20; Shen, Z., Ning, F., Zhou, W., Superspreading SARS events, Beijing, 2003 (2004) Emerg Infect Dis, 10, pp. 256-260; Holshue, M., DeBolt, C., Lindquist, S., First case of 2019 novel coronavirus in the United States (2020) N Engl J Med, 382, pp. 929-936; Interim guidance for preventing the spread of coronavirus disease 2019 (COVID-19) in homes and residential communities (2020), https://www.cdc.gov/coronavirus/2019-ncov/hcp/guidance-prevent-spread.html, Centers for Disease Control and Prevention (Accessed 19 February 2020); Evaluating and reporting persons under investigation (PUI) (2020), https://www.cdc.gov/coronavirus/2019-ncov/hcp/clinical-criteria.html, Centers for Disease Control and Prevention (Accessed 19 February 2020)","McPherson, T.D.; Chicago Department of Public HealthUnited States; email: oko9@cdc.gov",,Lancet Publishing Group,1406736,,LANCA,32178768,English,Lancet,Article,Final,Open Access,Scopus,2-s2.0-85081935465,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Kaplan E.H.,7401664592;,Containing 2019-nCoV (Wuhan) coronavirus,2020,Health Care Management Science,,,,,,,,10.1007/s10729-020-09504-6,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082551609&doi=10.1007%2fs10729-020-09504-6&partnerID=40&md5=73e7b75c30a50f24ad9d2f1f136e9ad8,"William N. and Marie A. Beach Professor of Operations Research, Professor of Public Health, Professor of Engineering, Yale School of Management, 165 Whitney Avenue, New Haven, CT 06511, United States","Kaplan, E.H., William N. and Marie A. Beach Professor of Operations Research, Professor of Public Health, Professor of Engineering, Yale School of Management, 165 Whitney Avenue, New Haven, CT 06511, United States","The novel coronavirus 2019-nCoV first appeared in December 2019 in Wuhan, China. While most of the initial cases were linked to the Huanan Seafood Wholesale Market, person-to-person transmission has been verified. Given that a vaccine cannot be developed and deployed for at least a year, preventing further transmission relies upon standard principles of containment, two of which are the isolation of known cases and the quarantine of persons believed at high risk of exposure. This note presents probability models for assessing the effectiveness of case isolation and quarantine within a community during the initial phase of an outbreak with illustrations based on early observations from Wuhan. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.",Containment; Coronavirus; Isolation; Probability modeling; Quarantine,,"Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med; Rothe, C., Schunk, M., Sothmann, P., Bretzel, G., Froeschl, G., Wallrauch, C., Zimmer, T., Hoelscher, M., Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany (2020) New England Journal of Medicine, 382 (10), pp. 970-971; Kupferschmidt, K., (2020) Study claiming new coronavirus can be transmitted by people without symptoms was flawed, , https://www.sciencemag.org/news/2020/02/paper-non-symptomatic-patient-transmitting-coronavirus-wrong, Science February 3, 2020, Accessed 5 February 2020; Chan-Yeung, M., Xu, R.-H., SARS: Epidemiology (2003) Respirology, 8, pp. S9-S14. , https://onlinelibrary.wiley.com/doi/epdf/10.1046/j.1440-1843.2003.00518.x; Killerby, M.E., Biggs, H.M., Midgley, C.M., Gerber, S.I., Watson, J.T., Middle East respiratory syndrome coronavirus transmission (2020) Emerg Infect Dis, 26 (2), pp. 191-198; Wang, C., Horby, P.W., Hayden, F.G., Gao, G.F., A novel coronavirus outbreak of global health concern (2020) The Lancet, 395 (10223), pp. 470-473; Britton, T., Tomba, G.S., Estimation in emerging epidemics: Biases and remedies (2019) J R Soc Interface, 16, p. 20180670; Anderson, R.M., May, R.M., (1991) Infectious diseases of humans: Dynamics and control, , Oxford University Press, Oxford; Wu, J.T., Leung, K., Leung, G.M., Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study (2020) The Lancet, 395 (10225), pp. 689-697; Imai, N., Cori, A., Dorigatti, I., Baguelin, M., Donnelly, C.A., Riley, S., Ferguson, N.M., (2020) Report 3: Transmissibility of 2019-nCoV MRC centre for global infectious disease analysis, , https://www.imperial.ac.uk/media/imperial-college/medicine/sph/ide/gida-fellowships/Imperial-2019-nCoV-transmissibility.pdf, Imperial College, London: https://www.imperial.ac.uk/media/imperial-college/medicine/sph/ide/gida-fellowships/Imperial-2019-nCoV-transmissibility.pdf, Accessed 1 February 2020; Becker, N.G., (2015) Modeling to inform infections disease control, , CRC Press, Chapman & Hall, New York; Kaplan, E.H., Craft, D.L., Wein, L.M., Analyzing bioterror response logistics:the case of smallpox (2003) Math Biosci, 185, pp. 33-72; Borio, L., Gottlieb, S., Act now to prevent an American epidemic: Quarantines, flu vaccines and other steps to take before the Wuhan virus becomes widespread (2020) Wall Street Journal January, 28, p. 2020. , https://www.wsj.com/articles/act-now-to-prevent-an-american-epidemic-11580255335, Accessed 2 February 2020; Miller, S.L., Clements, N., Elliott, S.A., Subhash, S.S., Eagan, A., Radonovich, L.J., Implementing a negative-pressure isolation ward for a surge in airborne infectious patients (2017) Am J Infection Control, 45, pp. 652-659. , https://www.ajicjournal.org/article/S0196-6553(17)30092-5/pdf","Kaplan, E.H.; William N. and Marie A. Beach Professor of Operations Research, Professor of Public Health, Professor of Engineering, Yale School of Management, 165 Whitney Avenue, United States; email: edward.kaplan@yale.edu",,Springer,13869620,,,,English,Health Care Manage. Sci.,Article,Article in Press,Open Access,Scopus,2-s2.0-85082551609,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Yan Y., Chen H., Chen L., Cheng B., Diao P., Dong L., Gao X., Gu H., He L., Ji C., Jin H., Lai W., Lei T., Li L., Li L., Li R., Liu D., Liu W., Lu Q., Shi Y., Song J., Tao J., Wang B., Wang G., Wu Y., Xiang L., Xie J., Xu J., Yao Z., Zhang F., Zhang J., Zhong S., Li H., Li H.",57215965914;57215963619;16174585800;35733521100;57215963545;57215963678;7403873040;57193789932;56520694200;57215972464;57211689662;35205568300;7201362617;56344903000;57215971445;57215968169;57215971231;56518822500;57213875148;57215965958;14052963900;57215584453;7405915737;57197760259;57208470102;57215966259;57205639864;57212058302;7401468164;57199243824;35225639100;8246693200;39262077200;57196359677;,Consensus of Chinese experts on protection of skin and mucous membrane barrier for health-care workers fighting against coronavirus disease 2019,2020,Dermatologic Therapy,,,,,,,,10.1111/dth.13310,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082476080&doi=10.1111%2fdth.13310&partnerID=40&md5=7610c634ff945bcb32cdcf88ebfbbfa0,"Department of Dermatology, Peking University First Hospital, National Clinical Research Center for Skin and Immune Diseases, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Xicheng District, Beijing, China; Department of Dermatology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Hankou, Wuhan, China; Department of Dermatology, Wuhan No.1 Hospital, Wuhan, Hubei, China; Department of Dermatology, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China; Department of Dermatology, West China Hospital of Sichuan University, Wuhou District, Chengdu City, Sichuan Province, China; Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China; Department of Dermatology, Chinese Medical University First Hospital, Shenyang, Liaoning Province, China; Hospital for Skin Diseases, Chinese Academy of Medical Sciences, Nanjing, Jiangsu Province, China; Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Wuhua District, Kunming, Yunnan Province, China; Department of Dermatology, Peking Union Medical College Hospital, Dongcheng District, Beijing, China; Department of Dermatology, The Third Affiliated Hospital, Sun Yat-Sen University, Tianhe District, Guangzhou, Guangdong, China; Department of Dermatology, Renmin Hospital of Wuhan University, Wuhan, China; Department of Infection Control, Peking University First Hospital, Xicheng District, Beijing, China; Department of Dermatology, Air Force General Hospital of PLA, Haidian District, Beijing, China; Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, China; Department of Dermatology, Zhongnan Hospital of Wuhan University, Wuchang District, Wuhan, Hubei Province, China; Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Shijingshan District, Beijing, China; Department of Dermatology, Xijing Hospital, Air Force Medical University of PLA, Xi'an, Shaanxi, China; Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China; Department of Dermatology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Yangpu District, Shanghai, China; Shandong Academy of Medical Sciences, Ji'nan, Shandong Province, China; Department of Dermatology, Peking University People's Hospital, Xicheng District, Beijing, China; Department of Dermatology, Hainan Hospital of PLA General Hospital, Sanya, Hainan Province, China","Yan, Y., Department of Dermatology, Peking University First Hospital, National Clinical Research Center for Skin and Immune Diseases, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Xicheng District, Beijing, China; Chen, H., Department of Dermatology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Hankou, Wuhan, China; Chen, L., Department of Dermatology, Wuhan No.1 Hospital, Wuhan, Hubei, China; Cheng, B., Department of Dermatology, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China; Diao, P., Department of Dermatology, West China Hospital of Sichuan University, Wuhou District, Chengdu City, Sichuan Province, China; Dong, L., Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China; Gao, X., Department of Dermatology, Chinese Medical University First Hospital, Shenyang, Liaoning Province, China; Gu, H., Hospital for Skin Diseases, Chinese Academy of Medical Sciences, Nanjing, Jiangsu Province, China; He, L., Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Wuhua District, Kunming, Yunnan Province, China; Ji, C., Department of Dermatology, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China; Jin, H., Department of Dermatology, Peking Union Medical College Hospital, Dongcheng District, Beijing, China; Lai, W., Department of Dermatology, The Third Affiliated Hospital, Sun Yat-Sen University, Tianhe District, Guangzhou, Guangdong, China; Lei, T., Department of Dermatology, Renmin Hospital of Wuhan University, Wuhan, China; Li, L., Department of Dermatology, West China Hospital of Sichuan University, Wuhou District, Chengdu City, Sichuan Province, China; Li, L., Department of Infection Control, Peking University First Hospital, Xicheng District, Beijing, China; Li, R., Department of Dermatology, Peking University First Hospital, National Clinical Research Center for Skin and Immune Diseases, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Xicheng District, Beijing, China; Liu, D., Department of Dermatology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Hankou, Wuhan, China; Liu, W., Department of Dermatology, Air Force General Hospital of PLA, Haidian District, Beijing, China; Lu, Q., Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, China; Shi, Y., Department of Dermatology, Renmin Hospital of Wuhan University, Wuhan, China; Song, J., Department of Dermatology, Zhongnan Hospital of Wuhan University, Wuchang District, Wuhan, Hubei Province, China; Tao, J., Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China; Wang, B., Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Shijingshan District, Beijing, China; Wang, G., Department of Dermatology, Xijing Hospital, Air Force Medical University of PLA, Xi'an, Shaanxi, China; Wu, Y., Department of Dermatology, Peking University First Hospital, National Clinical Research Center for Skin and Immune Diseases, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Xicheng District, Beijing, China; Xiang, L., Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China; Xie, J., Department of Dermatology, Zhongnan Hospital of Wuhan University, Wuchang District, Wuhan, Hubei Province, China; Xu, J., Department of Dermatology, Huashan Hospital, Fudan University, Shanghai, China; Yao, Z., Department of Dermatology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Yangpu District, Shanghai, China; Zhang, F., Shandong Academy of Medical Sciences, Ji'nan, Shandong Province, China; Zhang, J., Department of Dermatology, Peking University People's Hospital, Xicheng District, Beijing, China; Zhong, S., Department of Dermatology, Peking University First Hospital, National Clinical Research Center for Skin and Immune Diseases, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Xicheng District, Beijing, China; Li, H., Department of Dermatology, Hainan Hospital of PLA General Hospital, Sanya, Hainan Province, China; Li, H., Department of Dermatology, Peking University First Hospital, National Clinical Research Center for Skin and Immune Diseases, Beijing Key Laboratory of Molecular Diagnosis on Dermatoses, Xicheng District, Beijing, China","Health professions preventing and controlling Coronavirus Disease 2019 are prone to skin and mucous membrane injury, which may cause acute and chronic dermatitis, secondary infection and aggravation of underlying skin diseases. This is a consensus of Chinese experts on protective measures and advice on hand-cleaning- and medical-glove-related hand protection, mask- and goggles-related face protection, UV-related protection, eye protection, nasal and oral mucosa protection, outer ear, and hair protection. It is necessary to strictly follow standards of wearing protective equipment and specification of sterilizing and cleaning. Insufficient and excessive protection will have adverse effects on the skin and mucous membrane barrier. 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(2003) PLA Health, 5, p. 30; Zhang, J., Feng, X., Tai, B., Mouthwash and oral hygiene (2008) J Dental Prevent Treat, 16, pp. 51-56. , https://doi.org/10.3969/j.issn.1006-5245.2008.02.001; Coleman, P., Improving oral health care for the frail elderly: a review of widespread problems and best practices (2002) Geriatr Nurs, 23, pp. 189-199. , https://doi.org/10.1067/mgn.2002.126964; Zhao, B., (2017) China Clinical Dermatology, , 2nd ed., Nanjing, Pheonix Science Press; Zhang, X., Zhang, J., Lu, Q., (2019) Teacher's Book for Dermatology and Venereology, , Beijing, People's Medical Publishing House","Li, H.; Department of Dermatology, Hainan Hospital of PLA General HospitalChina; email: lhengjin@163.com",,Blackwell Publishing Inc.,13960296,,DETHF,32170800,English,Dermatol. Ther.,Article,Article in Press,Open Access,Scopus,2-s2.0-85082476080,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Killerby M.E., Biggs H.M., Midgley C.M., Gerber S.I., Watson J.T.",57207624890;46460986500;56372310100;56656063700;55374101200;,Middle east respiratory syndrome coronavirus transmission,2020,Emerging Infectious Diseases,26,2,,191,198,,4,10.3201/eid2602.190697,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078150230&doi=10.3201%2feid2602.190697&partnerID=40&md5=6f97ac842038a245c5080f81e18285b5,"Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Atlanta, GA 30329-4027, United States","Killerby, M.E., Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Atlanta, GA 30329-4027, United States; Biggs, H.M., Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Atlanta, GA 30329-4027, United States; Midgley, C.M., Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Atlanta, GA 30329-4027, United States; Gerber, S.I., Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Atlanta, GA 30329-4027, United States; Watson, J.T., Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Atlanta, GA 30329-4027, United States","Middle East respiratory syndrome coronavirus (MERS-CoV) infection causes a spectrum of respiratory illness, from asymptomatic to mild to fatal. MERS-CoV is transmitted sporadically from dromedary camels to humans and occasionally through human-to-human contact. Current epidemiologic evidence supports a major role in transmission for direct contact with live camels or humans with symptomatic MERS, but little evidence suggests the possibility of transmission from camel products or asymptomatic MERS cases. Because a proportion of case-patients do not report direct contact with camels or with persons who have symptomatic MERS, further research is needed to conclusively determine additional mechanisms of transmission, to inform public health practice, and to refine current precautionary recommendations. © 2020 Centers for Disease Control and Prevention (CDC). 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Munyua, P., Corman, V.M., Bitek, A., Osoro, E., Meyer, B., Müller, M.A., No serologic evidence of Middle East respiratory syndrome coronavirus infection among camel farmers exposed to highly seropositive camel herds: A household linked study, Kenya, 2013 (2017) Am J Trop Med Hyg., 96, pp. 1318-1324","Killerby, M.E.; Centers for Disease Control and Prevention, 1600 Clifton Rd NE, United States; email: lxo9@cdc.gov",,Centers for Disease Control and Prevention (CDC),10806040,,EIDIF,31961300,English,Emerg. Infect. Dis.,Article,Final,Open Access,Scopus,2-s2.0-85078150230,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Qing E., Hantak M., Perlman S., Gallagher T.",57207584493;56652220600;7102708317;7202310503;,Distinct roles for sialoside and protein receptors in coronavirus infection,2020,mBio,11,1, e02764-19,,,,,10.1128/mBio.02764-19,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079339383&doi=10.1128%2fmBio.02764-19&partnerID=40&md5=2361bb06692c58e0fd36afb6bc64500d,"Department of Microbiology and Immunology, Loyola University Chicago, Maywood, IL, United States; Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, United States; Department of Neurobiology and Anatomy, University of Utah, Salt Lake City, UT, United States","Qing, E., Department of Microbiology and Immunology, Loyola University Chicago, Maywood, IL, United States; Hantak, M., Department of Microbiology and Immunology, Loyola University Chicago, Maywood, IL, United States; Perlman, S., Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, United States; Gallagher, T., Department of Microbiology and Immunology, Loyola University Chicago, Maywood, IL, United States, Department of Neurobiology and Anatomy, University of Utah, Salt Lake City, UT, United States","Coronaviruses (CoVs) are common human and animal pathogens that can transmit zoonotically and cause severe respiratory disease syndromes. CoV infection requires spike proteins, which bind viruses to host cell receptors and catalyze virus-cell membrane fusion. Several CoV strains have spike proteins with two receptor-binding domains, an S1A that engages host sialic acids and an S1B that recognizes host transmembrane proteins. As this bivalent binding may enable broad zoonotic CoV infection, we aimed to identify roles for each receptor in distinct infection stages. Focusing on two betacoronaviruses, murine JHM-CoV and human Middle East respiratory syndrome coronavirus (MERS-CoV), we found that virus particle binding to cells was mediated by sialic acids; however, the transmembrane protein receptors were required for a subsequent virus infection. These results favored a two-step process in which viruses first adhere to sialic acids and then require subsequent engagement with protein receptors during infectious cell entry. However, sialic acids sufficiently facilitated the later stages of virus spread through cell-cell membrane fusion, without requiring protein receptors. This virus spread in the absence of the prototype protein receptors was increased by adaptive S1A mutations. Overall, these findings reveal roles for sialic acids in virus-cell binding, viral spike protein-directed cell-cell fusion, and resultant spread of CoV infections. IMPORTANCE CoVs can transmit from animals to humans to cause serious disease. This zoonotic transmission uses spike proteins, which bind CoVs to cells with two receptor-binding domains. Here, we identified the roles for the two binding processes in the CoV infection process. Binding to sialic acids promoted infection and also supported the intercellular expansion of CoV infections through syncytial development. Adaptive mutations in the sialic acid-binding spike domains increased the intercellular expansion process. 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Chan, C.-M., Chu, H., Wang, Y., Wong, B.-Y., Zhao, X., Zhou, J., Yang, D., Yuen, K.-Y., Carcinoem-bryonic antigen-related cell adhesion molecule 5 is an important surface attachment factor that facilitates entry of Middle East respiratory syn-drome coronavirus (2016) J Virol, 90, pp. 9114-9127. , https://doi.org/10.1128/JVI.01133-16; Chu, H., Chan, C.-M., Zhang, X., Wang, Y., Yuan, S., Zhou, J., Au-Yeung, R.-H., Yuen, K.-Y., Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells (2018) J Biol Chem, 293, pp. 11709-11726. , https://doi.org/10.1074/jbc.RA118.001897; Schnaar, R.L., Gerardy-Schahn, R., Hildebrandt, H., Sialic acids in the brain: Gangliosides and polysialic acid in nervous system development, stability, disease, and regeneration (2014) Physiol Rev, 94, pp. 461-518. , https://doi.org/10.1152/physrev.00033.2013; Massa, P.T., Wege, H., Ter Meulen, V., Analysis of murine hepatitis virus (JHM strain) tropism toward Lewis rat glial cells in vitro. Type I astrocytes and brain macrophages (microglia) as primary glial cell targets (1986) Lab Invest, 55, pp. 318-327; Massa, P.T., Wege, H., Ter Meulen, V., Growth pattern of various JHM coronavirus isolates in primary rat glial cell cultures correlates with differing neurotropism in vivo (1988) Virus Res, 9, pp. 133-144. , https://doi.org/10.1016/0168-1702(88)90028-7; van Berlo, M.F., Warringa, R., Wolswijk, G., Lopes-Cardozo, M., Vulnerability of rat and mouse brain cells to murine hepatitis virus (JHM-strain): Studies in vivo and in vitro (1989) Glia, 2, pp. 85-93. , https://doi.org/10.1002/glia.440020204; Chen, Y., Lu, S., Jia, H., Deng, Y., Zhou, J., Huang, B., Yu, Y., Tan, W., A novel neutralizing monoclonal antibody targeting the N-terminal domain of the MERS-CoV spike protein (2017) Emerg Microbes Infect, 6, p. e60. , https://doi.org/10.1038/emi.2017.50; Rao, P.V., Gallagher, T.M., Intracellular complexes of viral spike and cellular receptor accumulate during cytopathic murine coronavirus infections (1998) Jvirol, 72, pp. 3278-3288. , https://doi.org/10.1128/JVI.72.4.3278-3288.1998; Gallagher, T.M., Murine coronavirus membrane fusion is blocked by modification of thiols buried within the spike protein (1996) J Virol, 70, pp. 4683-4690. , https://doi.org/10.1128/JVI.70.7.4683-4690.1996; Rosenberger, C.M., Podyminogin, R.L., Askovich, P.S., Navarro, G., Kaiser, S.M., Sanders, C.J., McClaren, J.L., Aderem, A., Characterization of innate responses to influenza virus infection in a novel lung type I epithelial cell model (2014) J Gen Virol, 95, pp. 350-362. , https://doi.org/10.1099/vir.0.058438-0; Hirano, N., Fujiwara, K., Hino, S., Matumoto, M., Replication and plaque formation of mouse hepatitis virus (MHV-2) in mouse cell line DBT culture (1974) Arch Gesamte Virusforsch, 44, pp. 298-302. , https://doi.org/10.1007/bf01240618; Hirano, N., Fujiwara, K., Matumoto, M., Mouse hepatitis virus (MHV-2). Plaque assay and propagation in mouse cell line DBT cells (1976) Jpn J Microbiol, 20, pp. 219-225. , https://doi.org/10.1111/j.1348-0421.1976.tb00978.x; Zhang, R., Li, Y., Cowley, T.J., Steinbrenner, A.D., Phillips, J.M., Yount, B.L., Baric, R.S., Weiss, S.R., The nsp1, nsp13, and M proteins contribute to the hepatotropism of murine coronavirus JHM.WU (2015) J Virol, 89, pp. 3598-3609. , https://doi.org/10.1128/JVI.03535-14; Shulla, A., Gallagher, T., Role of spike protein endodomains in regulating coronavirus entry (2009) J Biol Chem, 284, pp. 32725-32734. , https://doi.org/10.1074/jbc.M109.043547; van Boheemen, S., de Graaf, M., Lauber, C., Bestebroer, T.M., Raj, V.S., Zaki, A.M., Osterhaus, A., Fouchier, R., Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans (2012) Mbio, 3, p. e00473. , https://doi.org/10.1128/mBio.00473-12; Nakane, S., Matsuda, Z., Dual split protein (DSP) assay to monitor cell-cell membrane fusion (2015) Methods Mol Biol, 1313, pp. 229-236. , https://doi.org/10.1007/978-1-4939-2703-6_17; Teeranaipong, P., Hosoya, N., Kawana-Tachikawa, A., Fujii, T., Koibuchi, T., Nakamura, H., Koga, M., Iwamoto, A., Development of a rapid cell-fusion-based phenotypic HIV-1 tropism assay (2013) J Int AIDS Soc, 16. , https://doi.org/10.7448/IAS.16.1.18723; Whitt, M.A., Generation of VSV pseudotypes using recombinant ΔG-VSV for studies on virus entry, identification of entry inhibitors, and immune responses to vaccines (2010) J Virol Methods, 169, pp. 365-374. , https://doi.org/10.1016/j.jviromet.2010.08.006; Brouillette, R.B., Phillips, E.K., Ayithan, N., Maury, W., Differences in glycoprotein complex receptor binding site accessibility prompt poor cross-reactivity of neutralizing antibodies between closely related arenaviruses (2017) J Virol, 91, p. e01454. , https://doi.org/10.1128/JVI.01454-16; Bender, S.J., Phillips, J.M., Scott, E.P., Weiss, S.R., Murine coronavirus receptors are differentially expressed in the central nervous system and play virus strain-dependent roles in neuronal spread (2010) J Virol, 84, pp. 11030-11044; Phillips, J.J., Chua, M.M., Rall, G.F., Weiss, S.R., Murine coronavirus spike glycoprotein mediates degree of viral spread, inflammation, and virus-induced immunopathology in the central nervous system (2002) Virology, 301, pp. 109-120","Hantak, M.; Department of Neurobiology and Anatomy, University of UtahUnited States; email: tgallag@luc.edu",,American Society for Microbiology,21612129,,,32047128,English,mBio,Article,Final,Open Access,Scopus,2-s2.0-85079339383,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Repici A., Maselli R., Colombo M., Gabbiadini R., Spadaccini M., Anderloni A., Carrara S., Fugazza A., Di Leo M., Galtieri P.A., Pellegatta G., Ferrara E.C., Azzolini E., Lagioia M.",8763695000;24176079000;57206516090;57215931356;57194572265;6602997370;7003469474;6507192953;36713404800;57194703410;56480696700;13907011600;55837885300;25930878000;,Coronavirus (COVID-19) outbreak: what the department of endoscopy should know,2020,Gastrointestinal Endoscopy,,,,,,,,10.1016/j.gie.2020.03.019,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082406228&doi=10.1016%2fj.gie.2020.03.019&partnerID=40&md5=5027a289c941013f71168efa85245943,"Digestive Endoscopy Unit, Division of Gastroenterology, Humanitas Clinical and Research Center, Milan, Italy; Department of Biomedical Sciences, Humanitas University, Milan, Italy; Clinical Quality Department, Humanitas Clinical and Research Center, Milan, Italy","Repici, A., Digestive Endoscopy Unit, Division of Gastroenterology, Humanitas Clinical and Research Center, Milan, Italy, Department of Biomedical Sciences, Humanitas University, Milan, Italy; Maselli, R., Digestive Endoscopy Unit, Division of Gastroenterology, Humanitas Clinical and Research Center, Milan, Italy; Colombo, M., Digestive Endoscopy Unit, Division of Gastroenterology, Humanitas Clinical and Research Center, Milan, Italy, Department of Biomedical Sciences, Humanitas University, Milan, Italy; Gabbiadini, R., Digestive Endoscopy Unit, Division of Gastroenterology, Humanitas Clinical and Research Center, Milan, Italy, Department of Biomedical Sciences, Humanitas University, Milan, Italy; Spadaccini, M., Digestive Endoscopy Unit, Division of Gastroenterology, Humanitas Clinical and Research Center, Milan, Italy, Department of Biomedical Sciences, Humanitas University, Milan, Italy; Anderloni, A., Digestive Endoscopy Unit, Division of Gastroenterology, Humanitas Clinical and Research Center, Milan, Italy; Carrara, S., Digestive Endoscopy Unit, Division of Gastroenterology, Humanitas Clinical and Research Center, Milan, Italy; Fugazza, A., Digestive Endoscopy Unit, Division of Gastroenterology, Humanitas Clinical and Research Center, Milan, Italy; Di Leo, M., Digestive Endoscopy Unit, Division of Gastroenterology, Humanitas Clinical and Research Center, Milan, Italy, Department of Biomedical Sciences, Humanitas University, Milan, Italy; Galtieri, P.A., Digestive Endoscopy Unit, Division of Gastroenterology, Humanitas Clinical and Research Center, Milan, Italy; Pellegatta, G., Digestive Endoscopy Unit, Division of Gastroenterology, Humanitas Clinical and Research Center, Milan, Italy; Ferrara, E.C., Digestive Endoscopy Unit, Division of Gastroenterology, Humanitas Clinical and Research Center, Milan, Italy; Azzolini, E., Clinical Quality Department, Humanitas Clinical and Research Center, Milan, Italy; Lagioia, M., Clinical Quality Department, Humanitas Clinical and Research Center, Milan, Italy","Italy recorded its first case of confirmed acute respiratory illness because of coronavirus on February 18, 2020, soon after the initial reports in China. Since that time, Italy and nations throughout the world have adopted very stringent and severe measures to protect populations from spread of infection. Despite these measures, the number of infected people is growing exponentially, with a significant number of patients developing acute respiratory insufficiency. Endoscopy departments face significant risk for diffusion of respiratory diseases that can be spread via an airborne route, including aspiration of oral and fecal material via endoscopes. The purpose of this article is to discuss the measures, with specific focus on personal protection equipment and dress code modalities, implemented in our hospital to prevent further dissemination of COVID-19 infection. © 2020 American Society for Gastrointestinal Endoscopy",,,"Weiss, S.R., Leibowitz, J.L., Coronavirus pathogenesis (2011) Adv Virus Res, 81, pp. 85-164; Pneumonia of unknown cause—China https://www.who.int/csr/don/05-january-2020-pneumonia-of-unkown-cause-china/en/, Available at: (Accessed 14 February 2020); World Health Organization, (2020), https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200310-sitrep-50-covid-19.pdf?sfvrsn=55e904fb_2, Coronavirus disease (COVID-2019) situation report—50. Available at: Accessed March 10; Diagnosis and treatment of new coronavirus pneumonia (version 5) http://www.nhc.gov.cn/, Available at: (Accessed 30 January 2020); Chan Jasper, F.W., Yuan, S.F., Kok, K.H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person to-person transmission: a study of a family cluster (2020) Lancet, 395, pp. 514-523; Novel coronavirus (2019-nCoV) situation report http://www.who.int/docs/default-source/coronavirus/situation-report/20200127-sitrep-7-2019–ncov.pdf?sfvrs n=98ef7 9f5_2, Available at: (Accessed 10 March 2020); Wang, C., Horby, P.W., Hayden, F.G., A novel coronavirus outbreak of global health concern (2020) Lancet, 395, pp. 470-473; Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382, pp. 727-733; Siegel, J.D., Rhinehart, E., Jackson, M., Health Care Infection Control Practices Advisory Committee. 2007 Guideline for isolation precautions: preventing transmission of infectious agents in health care settings (2007) Am J Infect Control, 35 (10), pp. S65-164; Tang, J.W., Li, Y., Eames, I., Factors involved in the aerosol transmission of infection and control of ventilation in healthcare premises (2006) J Hosp Infect, 64, pp. 100-114; Johnston, E.R., Habib-Bein, N., Dueker, J.M., Risk of bacterial exposure to the endoscopists face during endoscopy (2019) Gastrointest Endosc, 89, pp. 818-824; Wong, T.W., Lee, C.K., Tam, W., Cluster of SARS among medical students exposed to single patient, Hong Kong (2004) Emerg Infect Dis, 10, pp. 269-276; Gu, J., Han, B., Wang, J., COVID-19: gastrointestinal manifestations and potential fecal-oral transmission (2020) Gastroenterology, , S0016-5085(20)30281-X; Razai, M.S., Doerholt, K., Ladhani, S., Coronavirus disease 2019 (COVID-19): a guide for UK GPs (2020) BMJ, 368, p. m800; Personal protective equipment (PPE) needs in healthcare settings for the care of patients with suspected or confirmed novel coronavirus (2019-nCoV) 2020 (2020), European Centre for Disease Prevention and Control Stockholm, Sweden; Calderwood, A.H., Day, L.W., ASGE guideline for infection control during GI endoscopy (2018) Gastrointest Endosc, 87, pp. 1167-1179; Beilenhoff, U., Biering, H., Blum, R., Reprocessing of flexible endoscopes and endoscopic accessories used in gastrointestinal endoscopy: position statement of the European Society of Gastrointestinal Endoscopy (ESGE) and European Society of Gastroenterology Nurses and Associates (ESGENA)—update 2018 (2018) Endoscopy, 50, pp. 1205-1234; Disinfection of healthcare equipment. Guideline for disinfection and sterilization in healthcare facilities (2008), https://www.cdc.gov/infectioncontrol/guidelines/disinfection/healthcare-equipment.html, Available at: (Accessed 10 March 2020)","Repici, A.; Digestive Endoscopy Unit, Division of Gastroenterology, Humanitas Clinical and Research Center, Via Manzoni 56, Italy; email: alessandro.repici@hunimed.eu",,Mosby Inc.,165107,,GAENB,32179106,English,Gastrointest. Endosc.,Article,Article in Press,Open Access,Scopus,2-s2.0-85082406228,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Ma X.-L., Chen Z., Zhu J.-J., Shen X.-X., Wu M.-Y., Shi L.-P., Du L.-Z., Fu J.-F., Shu Q.",36114416400;7409485642;57215778619;55450898100;55729402600;37001938200;7201905885;8429908700;57210698907;,Management strategies of neonatal jaundice during the coronavirus disease 2019 outbreak,2020,World Journal of Pediatrics,,,,,,,,10.1007/s12519-020-00347-3,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081008949&doi=10.1007%2fs12519-020-00347-3&partnerID=40&md5=ac1220b8d0ff805b13d43d494c0c5898,"Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, 310052, China; National Clinical Research Center for Child Health, National Children’s Regional Medical Center, Hangzhou, 310052, China; Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China","Ma, X.-L., Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, 310052, China, National Clinical Research Center for Child Health, National Children’s Regional Medical Center, Hangzhou, 310052, China; Chen, Z., Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, 310052, China, National Clinical Research Center for Child Health, National Children’s Regional Medical Center, Hangzhou, 310052, China; Zhu, J.-J., Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China; Shen, X.-X., Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, 310052, China, National Clinical Research Center for Child Health, National Children’s Regional Medical Center, Hangzhou, 310052, China; Wu, M.-Y., Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China; Shi, L.-P., Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, 310052, China, National Clinical Research Center for Child Health, National Children’s Regional Medical Center, Hangzhou, 310052, China; Du, L.-Z., Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, 310052, China, National Clinical Research Center for Child Health, National Children’s Regional Medical Center, Hangzhou, 310052, China; Fu, J.-F., Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, 310052, China, National Clinical Research Center for Child Health, National Children’s Regional Medical Center, Hangzhou, 310052, China; Shu, Q., Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, 310052, China, National Clinical Research Center for Child Health, National Children’s Regional Medical Center, Hangzhou, 310052, China","The outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV) has become a most challenging health emergency. Owing to rigorous quarantine and control measures taken in China, routine neonatal health surveillance and follow-up have become challenging. Without follow-up surveillance, some rapid and progressive newborn diseases, such as bilirubin encephalopathy, may be ignored. The characteristics of onset age of kernicterus suggest that monitoring of bilirubin level at home provides a useful way to alert hospital visits and to prevent the development of extremely hyperbilirubinemia. Therefore, we developed an online follow-up program for convenient monitoring of bilirubin level of newborns that is based on our practical experiences. The aim is to make our management strategies of neonatal jaundice tailored to the infection prevention and control during the COVID-19 epidemic. © 2020, Children's Hospital, Zhejiang University School of Medicine.",Follow-up; Hyperbilirubinemia; Internet hospital; New coronavirus pneumonia; Newborn,,"Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., Coronavirus investigating, and research team A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with novel coronavirus in Wuhan, China (2020) Lancet; Shen, K.L., Yang, Y.H., Wang, T.Y., Zhao, D.C., Jiang, Y., Jin, R.M., Diagnosis, treatment, and prevention of novel coronavirus infection in children: experts' consensus statement (2020) World J Pediatr; Chen, H.J., Guo, J.J., Wang, C., Luo, F., Yu, X.C., Zhang, W., Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records (2020) Lancet; Zhu, H.P., Wang, L., Fang, C.Z., Peng, S.C., Zhang, L.H., Chang, G.P., Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia (2019) Transl Pediatr.; Du, L.Z., Ma, X.L., International perspectives: hyperbilirubinemia and kernicterus in neonates in China (2012) NeoReviews, 13, pp. e141-e144; Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation (2004) Pediatrics, 114, pp. 297-316; Bhutani, V.K., Johnson, L., Sivieri, E.M., Predictive ability of a predischarge hour-specific serum bilirubin for subsequent significant hyperbilirubinemia in healthy term and near-term newborns (1999) Pediatrics, 103, pp. 6-14. , COI: 1:STN:280:DyaK1M7hslKjsg%3D%3D; Taylor, J.A., Stout, J.W., de Greef, L., Goel, M., Patel, S., Chung, E.K., Use of a smartphone app to assess neonatal jaundice (2017) Pediatrics, 140; Rong, Z.H., Luo, F., Ma, L.Y., Chen, L., Wu, L., Liu, W., Evaluation of an automatic image-based screening technique for neonatal hyperbilirubinemia (2016) Zhonghua Er Ke Za Zhi, 54, pp. 597-600. , COI: 1:STN:280:DC%2BC2s3pslyltw%3D%3D, PID: 27510872, (in Chinese; Wang, L., Shi, Y., Xiao, T., Fu, J., Feng, X., Mu, D., Chinese expert consensus on the perinatal and neonatal management for the prevention and control of the 2019 novel coronavirus infection (First edition) (2020) Ann Transl Med, 8 (3), p. 47","Fu, J.-F.; Children’s Hospital, Zhejiang University School of MedicineChina; email: fjf68@zju.edu.cn",,Institute of Pediatrics of Zhejiang University,17088569,,,32112336,English,World J. Pediatr.,Review,Article in Press,Open Access,Scopus,2-s2.0-85081008949,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Mizumoto K., Chowell G.",55553077000;9845935500;,"Transmission potential of the novel coronavirus (COVID-19) onboard the diamond Princess Cruises Ship, 2020",2020,Infectious Disease Modelling,5,,,264,270,,1,10.1016/j.idm.2020.02.003,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080982357&doi=10.1016%2fj.idm.2020.02.003&partnerID=40&md5=a427eed527529e1daa0e70ccb9db3d6b,"Graduate School of Advanced Integrated Studies in Human Survivability, Kyoto University Yoshida-Nakaadachi-cho, Sakyo-ku, Kyoto, Japan; Hakubi Center for Advanced Research, Kyoto University, Yoshidahonmachi, Sakyo-ku, Kyoto, Japan; Department of Population Health Sciences, School of Public Health, Georgia State University, Georgia, Atlanta, United States; Division of International Epidemiology and Population Studies, Fogarty International Center, National Institutes of Health, Bethesda, United States","Mizumoto, K., Graduate School of Advanced Integrated Studies in Human Survivability, Kyoto University Yoshida-Nakaadachi-cho, Sakyo-ku, Kyoto, Japan, Hakubi Center for Advanced Research, Kyoto University, Yoshidahonmachi, Sakyo-ku, Kyoto, Japan, Department of Population Health Sciences, School of Public Health, Georgia State University, Georgia, Atlanta, United States; Chowell, G., Department of Population Health Sciences, School of Public Health, Georgia State University, Georgia, Atlanta, United States, Division of International Epidemiology and Population Studies, Fogarty International Center, National Institutes of Health, Bethesda, United States","An outbreak of COVID-19 developed aboard the Princess Cruises Ship during January–February 2020. Using mathematical modeling and time-series incidence data describing the trajectory of the outbreak among passengers and crew members, we characterize how the transmission potential varied over the course of the outbreak. Our estimate of the mean reproduction number in the confined setting reached values as high as ~11, which is higher than mean estimates reported from community-level transmission dynamics in China and Singapore (approximate range: 1.1–7). Our findings suggest that Rt decreased substantially compared to values during the early phase after the Japanese government implemented an enhanced quarantine control. Most recent estimates of Rt reached values largely below the epidemic threshold, indicating that a secondary outbreak of the novel coronavirus was unlikely to occur aboard the Diamond Princess Ship. © 2020 The Authors",Confined settings; Corona; Cruise; Epidemic; Next generation matrix,2019 novel coronavirus; adolescent; adult; Article; child; China; coronavirus disease 2019; Coronavirus infection; disease transmission; epidemic; government; human; incidence; infant; Japan; newborn; polymerase chain reaction; public health; ship,"Diekmann, O., Heesterbeek, J.A.P., Roberts, M.G., The construction of next-generation matrices for compartmental epidemic models (2010); Gan, N., Thomas, N., Culver, D., CNN. Over 1,700 frontline medics infected with coronavirus in China, presenting new crisis for the government (2020), https://edition.cnn.com/2020/02/13/asia/coronavirus-health-care-workers-infected-intl-hnk/index.html, Available from: (Accessed 24 February 2020); ’It's ruining everyone’: Eerie quiet reigns in coronavirus-hit south Korean city (2020) The guardian. Nemo Kim in Daegu, , https://www.theguardian.com/world/2020/feb/23/its-ruining-everyone-coronavirus-hit-south-korean-city-daegu, Avaiable from (Accessed 24 February 2020); Kumamotonichinichishinbun, (2020), https://kumanichi.com/column/syasetsu/1363649/, Available from:, [In Japanese] (Accessed 24 February 2020); Li, Q., Guan, X., Early transmission dynamics in wuhan, China, of novel coronavirus–infected pneumonia (2020) New England Journal of Medicine, , https://www.nejm.org/doi/full/10.1056/NEJMoa2001316, Available at:; Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Early transmission dynamics in wuhan, China, of novel coronavirus-infected pneumonia (2020) New England Journal of Medicine; Minister of Health, Labour and welfare, Japan https://www.mhlw.go.jp/stf/seisakunitsuite/bunya/0000164708_00001.html, Available from:, ([In Japanese]); Mizumoto, K., Kagaya, K., Chowell, G., Early epidemiological assessment of the transmission potential and virulence of 2019 novel coronavirus in wuhan city: China, 2019-2020 (2020); Mizumoto, K., Kagaya, K., Zarebski, A., Chowell, G., Estimating the asymptomatic ratio of 2019 novel coronavirus onboard the princess cruises ship (2020), (submitted for publication); Mizumoto, K., Tariq, A., Roosa, K., Kong, J., Yan, P., Chowell, G., (2019) Euro Surveill. Spatial variability in the reproduction number of Ebola virus disease, 24. , Democratic Republic of the Congo January-September 2019; National Instatitute of Infectious Disease, Japan (NIID) field briefing: Diamond princess COVID-19 cases (2020), https://www.niid.go.jp/niid/en/2019-ncov-e/9407-covid-dp-fe-01.html, Available from:; Nhk News Web, (2020), https://www3.nhk.or.jp/news/html/20200216/k10012288171000.html, Available from:, [In Japanese] (Accessed 24 February 2020); NPR. Coronavirus Found in China prisons, as cases spike in South Korea (2020), https://www.npr.org/2020/02/21/808002924/coronavirus-found-in-china-prisons-as-cases-spike-in-south-korea, Avaiable from (Accessed 24 February 2020); Read, J.M., Bridgen, J.R., Cummings, D.A., Ho, A., Jewell, C.P., Novel coronavirus 2019-nCoV: Early estimation of epidemiological parameters and epidemic predictions (2019); Sanche, S., The novel coronavirus, 2019-nCoV, is highly contagious and more infectious than initially estimated (2020); TariqA, Lee, Y., Roosa, K., Blumberg, S., Yan, P., Ma, S., (2020) Real-time monitoring the transmission potential of COVID-19 in Singapore, 21, p. 20026435. , medRxiv 2020.02; The New York TImes. U.S, Passengers evacuate quarantined cruise ship in Japan (2020), https://www.nytimes.com/2020/02/16/world/asia/coronavirus-japan-cruise-americans.html, Availalble from; Who, World health organization, coronavirus disease (2019), https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200218-sitrep-29-covid-19.pdf?sfvrsn=6262de9e_2, (COVID-19), Situation Report -29. Available from:; Wu, J.T., Leung, K., Leung, G.M., Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in wuhan, China: A modelling study (2020) Lancet, S0140–6736 (20), pp. 30260-30269","Mizumoto, K.; Graduate School of Advanced Integrated Studies in Human Survivability, Kyoto University Yoshida-Nakaadachi-cho, Sakyo-ku, Japan; email: mizumoto.kenji.5a@kyoto-u.ac.jp",,KeAi Communications Co.,24680427,,,,English,Infect. Dis. Modelling,Article,Final,Open Access,Scopus,2-s2.0-85080982357,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Bhattacharya M., Sharma A.R., Patra P., Ghosh P., Sharma G., Patra B.C., Lee S.-S., Chakraborty C.",57077950400;55366597500;57208142999;57211806892;57207173531;57196620512;55716392800;57205609348;,Development of epitope-based peptide vaccine against novel coronavirus 2019 (SARS-COV-2): Immunoinformatics approach,2020,Journal of Medical Virology,,,,,,,,10.1002/jmv.25736,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080892225&doi=10.1002%2fjmv.25736&partnerID=40&md5=2d404f639a9bec1be7a59112d6a404bc,"Institute for Skeletal Aging and Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do, South Korea; Department of Zoology, Vidyasagar University, Midnapore, West Bengal, India; Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chuncheon, South Korea; Department of Biotechnology, School of Life Science and Biotechnology, Adamas University, Kolkata, West Bengal, India","Bhattacharya, M., Institute for Skeletal Aging and Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do, South Korea, Department of Zoology, Vidyasagar University, Midnapore, West Bengal, India; Sharma, A.R., Institute for Skeletal Aging and Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do, South Korea; Patra, P., Department of Zoology, Vidyasagar University, Midnapore, West Bengal, India; Ghosh, P., Department of Zoology, Vidyasagar University, Midnapore, West Bengal, India; Sharma, G., Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chuncheon, South Korea; Patra, B.C., Department of Zoology, Vidyasagar University, Midnapore, West Bengal, India; Lee, S.-S., Institute for Skeletal Aging and Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do, South Korea; Chakraborty, C., Institute for Skeletal Aging and Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do, South Korea, Department of Biotechnology, School of Life Science and Biotechnology, Adamas University, Kolkata, West Bengal, India","Recently, a novel coronavirus (SARS-COV-2) emerged which is responsible for the recent outbreak in Wuhan, China. Genetically, it is closely related to SARS-CoV and MERS-CoV. The situation is getting worse and worse, therefore, there is an urgent need for designing a suitable peptide vaccine component against the SARS-COV-2. Here, we characterized spike glycoprotein to obtain immunogenic epitopes. Next, we chose 13 Major Histocompatibility Complex-(MHC) I and 3 MHC-II epitopes, having antigenic properties. These epitopes are usually linked to specific linkers to build vaccine components and molecularly dock on toll-like receptor-5 to get binding affinity. Therefore, to provide a fast immunogenic profile of these epitopes, we performed immunoinformatics analysis so that the rapid development of the vaccine might bring this disastrous situation to the end earlier. © 2020 Wiley Periodicals, Inc.",epitopes; immunoinformatics; SARS-COV-2; vaccine,,"Wang, C., Horby, P.W., Hayden, F.G., Gao, G.F., A novel coronavirus outbreak of global health concern (2020) The Lancet, 395, pp. 470-473; Zhou, P., Yang, X.-L., Wang, X.-G., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature, pp. 1-4; Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382, pp. 727-733; Hui, D.S., I Azhar, E., Madani, T.A., The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health—the latest 2019 novel coronavirus outbreak in Wuhan, China (2020) Int J Infect Dis, 91, pp. 264-266; Chan, J.F.-W., Yuan, S., Kok, K.-H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) The Lancet, 395, pp. 514-523; Carlos, W.G., Dela Cruz, C.S., Cao, B., Pasnick, S., Jamil, S., Novel Wuhan (2019-nCoV) coronavirus (2020) Am J Respir Crit Care Med, 201, pp. P7-P8; Perlman, S., Another decade, another coronavirus (2020) N Engl J Med, 382 (8), pp. 760-762; Phelan, A.L., Katz, R., Gostin, L.O., The Novel coronavirus originating in Wuhan, China: challenges for global health governance (2020) JAMA, 323, p. 709; Yin, D., Li, L., Song, X., A novel multi-epitope recombined protein for diagnosis of human brucellosis (2016) BMC Infect Dis, 16 (1), p. 219; Chung, M., Bernheim, A., Mei, X., CT imaging features of 2019 novel coronavirus (2019-nCoV) (2020) Radiology; Database resources of the National Center For Biotechnology Information (2016) Nucleic Acids Res, 44 (database issue), p. D7; Kim, Y., Ponomarenko, J., Zhu, Z., Immune epitope database analysis resource (2012) Nucleic Acids Res, 40 (W1), pp. W525-W530; Jespersen, M.C., Peters, B., Nielsen, M., Marcatili, P., BepiPred-2.0: improving sequence-based B-cell epitope prediction using conformational epitopes (2017) Nucleic Acids Res, 45 (W1), pp. W24-W29; Singh, H., Raghava, G., ProPred1: prediction of promiscuous MHC Class-I binding sites (2003) Bioinformatics, 19 (8), pp. 1009-1014; Singh, H., Raghava, G., ProPred: prediction of HLA-DR binding sites (2001) Bioinformatics, 17 (12), pp. 1236-1237; Doytchinova, I.A., Flower, D.R., VaxiJen: a server for prediction of protective antigens, tumour antigens and subunit vaccines (2007) BMC Bioinformatics, 8 (1), p. 4; Yang, Y., Faraggi, E., Zhao, H., Zhou, Y., Improving protein fold recognition and template-based modeling by employing probabilistic-based matching between predicted one-dimensional structural properties of query and corresponding native properties of templates (2011) Bioinformatics, 27 (15), pp. 2076-2082; Wiederstein, M., Sippl, M.J., ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins (2007) Nucleic Acids Res, 35 (suppl_2), pp. W407-W410; Laskowski, R., MacArthur, M., Thornton, J., (2006) PROCHECK: validation of protein-structure coordinates; Schneidman-Duhovny, D., Inbar, Y., Nussinov, R., Wolfson, H.J., PatchDock and SymmDock: servers for rigid and symmetric docking (2005) Nucleic Acids Res, 33 (suppl_2), pp. W363-W367; DeLano, W.L., Pymol: an open-source molecular graphics tool (2002) CCP4 Newsletter on protein crystallography, 40 (1), pp. 82-92; Chen, X., Zaro, J.L., Shen, W.-C., Fusion protein linkers: property, design and functionality (2013) Adv Drug Deliv Rev, 65 (10), pp. 1357-1369; Al-Moubarak, E., Simons, C., A homology model for Clostridium difficile methionyl tRNA synthetase: active site analysis and docking interactions (2011) J Mol Model, 17 (7), pp. 1679-1693; Patra, P., Ghosh, P., Patra, B.C., Bhattacharya, M., Biocomputational analysis and in silico characterization of an angiogenic protein (RNase5) in zebrafish (Danio rerio) (2019) Int J Pept Res Ther, pp. 1-11; Ramanathan, K., Shanthi, V., Sethumadhavan, R., In silico identification of catalytic residues in azobenzene reductase from Bacillus subtilis and its docking studies with azo dyes (2009) Interdiscip Sci: Comput Life Sci, 1 (4), pp. 290-297; Lavi, A., Ngan, C.H., Movshovitz-Attias, D., Detection of peptide-binding sites on protein surfaces: The first step toward the modeling and targeting of peptide-mediated interactions (2013) Proteins: Struct, Funct, Bioinf, 81 (12), pp. 2096-2105","Lee, S.-S.; Institute for Skeletal Aging and Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart HospitalSouth Korea; email: 123sslee@gmail.com",,John Wiley and Sons Inc.,1466615,,JMVID,32108359,English,J. Med. Virol.,Article,Article in Press,Open Access,Scopus,2-s2.0-85080892225,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Cheng Z.J., Shan J.",57215061951;57215039473;,2019 Novel coronavirus: where we are and what we know,2020,Infection,48,2,,155,163,,2,10.1007/s15010-020-01401-y,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079827431&doi=10.1007%2fs15010-020-01401-y&partnerID=40&md5=91022fcd1d820341d3d2faf7eb5b873a,"Institute of Allergy and Immunology, School of Medicine, Shenzhen University, Shenzhen, China; Center for Applied Genomics, The Children’s Hospital of Philadelphia, Philadelphia, United States; Institute of Medical Physics, University of Sydney, Sydney, Australia; Discipline of Child and Adolescence Health, The Faculty of Medicine and Health, University of Sydney, Sydney, Australia","Cheng, Z.J., Institute of Allergy and Immunology, School of Medicine, Shenzhen University, Shenzhen, China, Center for Applied Genomics, The Children’s Hospital of Philadelphia, Philadelphia, United States, Institute of Medical Physics, University of Sydney, Sydney, Australia; Shan, J., Discipline of Child and Adolescence Health, The Faculty of Medicine and Health, University of Sydney, Sydney, Australia","There is a current worldwide outbreak of a new type of coronavirus (2019-nCoV), which originated from Wuhan in China and has now spread to 17 other countries. Governments are under increased pressure to stop the outbreak spiraling into a global health emergency. At this stage, preparedness, transparency, and sharing of information are crucial to risk assessments and beginning outbreak control activities. This information should include reports from outbreak sites and from laboratories supporting the investigation. This paper aggregates and consolidates the virology, epidemiology, clinical management strategies from both English and Chinese literature, official news channels, and other official government documents. In addition, by fitting the number of infections with a single-term exponential model, we report that the infection is spreading at an exponential rate, with a doubling period of 1.8 days. © 2020, Springer-Verlag GmbH Germany, part of Springer Nature.",2019-nCoV; China; Clinical guideline; Coronavirus; COVID-19; Epidemiology; Literature review; Literature survey; Novel coronavirus; Review; Virology; Wuhan,China; Coronavirinae; government; nonhuman; practice guideline; review; virology,"Hui, D.S., Azhar, E., Madani, T.A., Ntoumi, F., Kock, R., Dar, O., The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health—the latest 2019 novel coronavirus outbreak in Wuhan, China (2020) Int J Infect Dis, 91, pp. 264-266; Zhou, P., Yang, X.-L., Wang, X.-G., Hu, B., Zhang, L., Zhang, W., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature, , in press; Wu, F., Zhao, S., Yu, B., Chen, Y.-M., Wang, W., Song, Z.-G., A new coronavirus associated with human respiratory disease in China (2020) Nature; Ji, W., Wang, W., Zhao, X., Zai, J., Li, X., Homologous recombination within the spike glycoprotein of the newly identified coronavirus may boost cross-species transmission from snake to human (2020) J Med Virol; Guo, Q., Li, M., Wang, C., Wang, P., Fang, Z., Tan, J., (2020) Host and Infectivity Prediction of Wuhan 2019 Novel Coronavirus Using Deep Learning Algorithm; Xu, X., Chen, P., Wang, J., Feng, J., Zhou, H., Li, X., Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission (2020) Sci China Life Sci, 63; Li, W., Sui, J., Huang, I.-C., Kuhn, J.H., Radoshitzky, S.R., Marasco, W.A., The S proteins of human coronavirus NL63 and severe acute respiratory syndrome coronavirus bind overlapping regions of ACE2 (2007) Virology, 367, pp. 367-374; Wu, K., Li, W., Peng, G., Li, F., Crystal structure of NL63 respiratory coronavirus receptor-binding domain complexed with its human receptor (2009) Proc Natl Acad Sci USA, 106, pp. 19970-19974; He, L., Ding, Y., Zhang, Q., Che, X., He, Y., Shen, H., Expression of elevated levels of pro-inflammatory cytokines in SARS-CoV-infected ACE2+ cells in SARS patients: relation to the acute lung injury and pathogenesis of SARS (2006) J Pathol, 210, pp. 288-297; Zhou, P., Yang, X.-L., Wang, X.-G., Hu, B., Zhang, L., Zhang, W., (2020) Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin; Zhao, Y., Zhao, Z., Wang, Y., Zhou, Y., Ma, Y., Zuo, W., (2020) Single-cell RNA expression profiling of ACE2, the putative receptor of Wuhan 2019-nCov; (2020), http://www.xinhuanet.com/2020-01/27/c_1125504355.htm; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan (2020) Lancet., , China, in press; Lucey, D., (2020), https://www.sciencemag.org/news/2020/01/wuhan-seafood-market-may-not-be-source-novel-virus-spreading-globally; Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med, , (, press; Chan, J.F., Yuan, S., Kok, K.H., To, K.K., Chu, H., Yang, J., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: A study of a family cluster (2020) Lancet, , in press; Read, J.M., Bridgen, J.R.E., Cummings, D.A.T., Ho, A., Jewell, C.P., (2020) Novel Coronavirus 2019-Ncov: Early Estimation of Epidemiological Parameters and Epidemic Predictions; Majumder, M., Mandl, K.D., (2020) Early Transmissibility Assessment of a Novel Coronavirus in Wuhan, , China. Available at SSRN; Tang, B., Wang, X., Li, Q., Bragazzi, N.L., Tang, S., Xiao, Y., (2020) Estimation of the Transmission Risk of 2019-Ncov and Its Implication for Public Health Interventions, , Available at SSRN; (2005) Statement on the Meeting of the International Health Regulations, , Emergency Committee regarding the outbreak of novel coronavirus (2019-nCoV); 2020; Althaus, C., (2020), https://twitter.com/C_Althaus/status/1220723566272045057?ref_src=twsrc%5Etfw%7Ctwcamp%5Etweetembed%7Ctwterm%5E1220723566272045057&ref_url=https%3A%2F%2Fwwwvoxcom%2F2020%2F1%2F28%2F21079946%2Fcoronavirus-china-wuhan-deaths-pandemic; Leung, G., Wu, J., Real-time nowcast and forecast on the extent of the Wuhan CoV outbreak, domestic and international spread (2020) Media Conference, , 27 January; Gardner, L., (2020) Modeling the Spread of 2019-Ncov., , https://systemsjhuedu/wp-content/uploads/2020/01/Gardner-JHU_nCoV-Modeling-Report_Jan-26pdf; (2020), http://www.nhc.gov.cn/xcs/yqtb/list_gzbd.shtml, NHC. 疫情通 报; (2020), https://3g.dxy.cn/newh5/view/pneumonia?from=timeline&isappinstalled=0, DXY. 疫情地 图; Nishiura, H.J., Sm Linton, N.M., Kinoshita, R., Yang, Y., Hayashi, K., The extent of transmission of novel coronavirus in Wuhan, China, 2020 (2020) J Clin Med, 9, p. 330; (2020), http://www.xinhuanet.com/politics/2020-01/28/c_1125506707.htm; Guidance, W., (2020) Clinical Management of Severe Acute Respiratory Infection When Novel Coronavirus (2019-Ncov) Infection is Suspected., , WHO; Guidance, C., (2020), https://www.gov.cn/zhengce/zhengceku/2020-01/28/5472673/files/0f96c10cc09d4d36a6f9a9f0b42d972b.pdf, 新型冠状病毒感染的肺炎 诊疗方案 (试行第四版); Davis, A.L., Carcillo, J.A., Aneja, R.K., Deymann, A.J., Lin, J.C., Nguyen, T.C., American College of Critical Care Medicine Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock (2017) Crit Care Med, 45, pp. 1061-1093; Rhodes, A., Evans, L.E., Alhazzani, W., Levy, M.M., Antonelli, M., Ferrer, R., Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016 (2017) Intensive Care Med, 43, pp. 304-377; Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study (2020) Lancet, , in press; Jaillon, S., Berthenet, K., Garlanda, C., Sexual dimorphism in innate immunity (2019) Clin Rev Allergy Immunol, 56, pp. 308-321; Papazian, L., Aubron, C., Brochard, L., Chiche, J.D., Combes, A., Dreyfuss, D., Formal guidelines: management of acute respiratory distress syndrome (2019) Ann Intensive Care","Cheng, Z.J.; Institute of Allergy and Immunology, School of Medicine, Shenzhen UniversityChina; email: zche2025@uni.sydney.edu.au",,Springer,3008126,,IFTNA,32072569,English,Infection,Review,Final,Open Access,Scopus,2-s2.0-85079827431,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Song F., Shi N., Shan F., Zhang Z., Shen J., Lu H., Ling Y., Jiang Y., Shi Y.",55769495600;57215864138;57215863981;57215864090;57199271114;7404842614;57215863428;57216098846;17342934100;,Emerging 2019 novel coronavirus (2019-NCoV) pneumonia,2020,Radiology,295,1,,210,217,,13,10.1148/radiol.2020200274,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081241418&doi=10.1148%2fradiol.2020200274&partnerID=40&md5=947e4504391d6d91c5cb8b1643759d41,"Department of Radiology, Shanghai Public Health Clinical Center, No. 2501 Caolang Road Jinshan District, Shanghai, 201508, China; Department of Infectious Disease, Shanghai Public Health Clinical Center, No. 2501 Caolang Road Jinshan District, Shanghai, 201508, China; Department of the Principal's Office, Fudan University, Shanghai, China; Cancer Center, University of Michigan, Ann Arbor, MI, United States; Shanghai Key Laboratory of Molecular Imaging, Shanghai, China","Song, F., Department of Radiology, Shanghai Public Health Clinical Center, No. 2501 Caolang Road Jinshan District, Shanghai, 201508, China; Shi, N., Department of Radiology, Shanghai Public Health Clinical Center, No. 2501 Caolang Road Jinshan District, Shanghai, 201508, China; Shan, F., Department of Radiology, Shanghai Public Health Clinical Center, No. 2501 Caolang Road Jinshan District, Shanghai, 201508, China; Zhang, Z., Department of Radiology, Shanghai Public Health Clinical Center, No. 2501 Caolang Road Jinshan District, Shanghai, 201508, China, Department of the Principal's Office, Fudan University, Shanghai, China; Shen, J., Department of Radiology, Shanghai Public Health Clinical Center, No. 2501 Caolang Road Jinshan District, Shanghai, 201508, China; Lu, H., Department of Infectious Disease, Shanghai Public Health Clinical Center, No. 2501 Caolang Road Jinshan District, Shanghai, 201508, China; Ling, Y., Department of Infectious Disease, Shanghai Public Health Clinical Center, No. 2501 Caolang Road Jinshan District, Shanghai, 201508, China; Jiang, Y., Cancer Center, University of Michigan, Ann Arbor, MI, United States; Shi, Y., Department of Radiology, Shanghai Public Health Clinical Center, No. 2501 Caolang Road Jinshan District, Shanghai, 201508, China, Shanghai Key Laboratory of Molecular Imaging, Shanghai, China","Background: The chest CT findings of patients with 2019 Novel Coronavirus (2019-nCoV) pneumonia have not previously been described in detail. Purpose: To investigate the clinical, laboratory, and imaging findings of emerging 2019-nCoV pneumonia in humans. Materials and Methods: Fifty-one patients (25 men and 26 women; age range 16–76 years) with laboratory-confirmed 2019-nCoV infection by using real-time reverse transcription polymerase chain reaction underwent thin-section CT. The imaging findings, clinical data, and laboratory data were evaluated. Results: Fifty of 51 patients (98%) had a history of contact with individuals from the endemic center in Wuhan, China. Fever (49 of 51, 96%) and cough (24 of 51, 47%) were the most common symptoms. Most patients had a normal white blood cell count (37 of 51, 73%), neutrophil count (44 of 51, 86%), and either normal (17 of 51, 35%) or reduced (33 of 51, 65%) lymphocyte count. CT images showed pure ground-glass opacity (GGO) in 39 of 51 (77%) patients and GGO with reticular and/ or interlobular septal thickening in 38 of 51 (75%) patients. GGO with consolidation was present in 30 of 51 (59%) patients, and pure consolidation was present in 28 of 51 (55%) patients. Forty-four of 51 (86%) patients had bilateral lung involvement, while 41 of 51 (80%) involved the posterior part of the lungs and 44 of 51 (86%) were peripheral. There were more consolidated lung lesions in patients 5 days or more from disease onset to CT scan versus 4 days or fewer (431 of 712 lesions vs 129 of 612 lesions; P , .001). Patients older than 50 years had more consolidated lung lesions than did those aged 50 years or younger (212 of 470 vs 198 of 854; P , .001). Follow-up CT in 13 patients showed improvement in seven (54%) patients and progression in four (31%) patients. Conclusion: Patients with fever and/or cough and with conspicuous ground-glass opacity lesions in the peripheral and posterior lungs on CT images, combined with normal or decreased white blood cells and a history of epidemic exposure, are highly suspected of having 2019 Novel Coronavirus (2019-nCoV) pneumonia. © RSNA, 2020.",,"COVID-19; severe acute respiratory syndrome coronavirus 2; adolescent; adult; age; Betacoronavirus; China; complication; Coronavirus infection; coughing; diagnostic imaging; epidemiology; female; fever; human; isolation and purification; leukocyte count; lung; male; middle aged; pathology; real time polymerase chain reaction; retrospective study; virus pneumonia; x-ray computed tomography; young adult; Adolescent; Adult; Age Factors; Betacoronavirus; China; Coronavirus Infections; Cough; Female; Fever; Humans; Leukocyte Count; Lung; Male; Middle Aged; Pneumonia, Viral; Real-Time Polymerase Chain Reaction; Retrospective Studies; Tomography, X-Ray Computed; Young Adult","ProMED-Mail, , https://promedmail.org/promed-post/?id=6864153, Accessed January 7, 2020; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Lancet, 2020. , Jan 24 Epub ahead of print Published correction Lancet 2020 Jan 30; Novel Coronavirus – Thailand (Ex-China), , http://www.who.int/csr/don/14-january-2020-novel-coronavirus-thailand/en/, Published January 14, 2020. Accessed January 19, 2020; Novel Coronavirus – Japan (Ex-China), , http://www.who.int/csr/don/17-january-2020-novel-coronavirus-japan-ex-china/en/, Published January 17, 2020. Accessed January 19, 2020; Novel Coronavirus – Republic of Korea (Ex-China), , http://www.who.int/csr/don/21-january-2020-novel-coronavirus-republic-of-koreaex-china/en/, Published January 21, 2020. Accessed January 23, 2020; First Travel-Related Case of 2019 Novel Coronavirus Detected in United States, , https://www.cdc.gov/media/releases/2020/p0121-novel-coronavirus-travel-case.html, Published January 21, 2020. Accessed January 23, 2020; Richman, D.D., Whitley, R.J., Hayden, F.G., (2016) Clinical Virology, , eds. 4th ed. Washington, DC: ASM Press; Ge, X.Y., Li, J.L., Yang, X.L., Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor (2013) Nature, 503 (7477), pp. 535-538; Hui, D.S., Azhar, E., Madani, T.A., The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health - The latest 2019 novel coronavirus outbreak in Wuhan, China (2020) Int J Infect Dis, 91, pp. 264-266; Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 N Engl J Med, 2020. , Jan 24 Epub ahead of print; Lei, J., Li, J., Li, X., Qi, X., CT imaging of the 2019 novel coronavirus (2019-NCoV) pneumonia Radiology, 2020. , Jan 31 Epub ahead of print; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study (2020) Lancet, , Jan 30 Epub ahead of print; Li, H., Weng, H., Lan, C., Comparison of patients with avian influenza A (H7N9) and influenza A (H1N1) complicated by acute respiratory distress syndrome (2018) Medicine (Baltimore), 97 (12); Wang, Q., Zhang, Z., Shi, Y., Jiang, Y., Emerging H7N9 influenza A (novel reassortant avian-origin) pneumonia: Radiologic findings (2013) Radiology, 268 (3), pp. 882-889; Koo, H.J., Lim, S., Choe, J., Choi, S.H., Sung, H., Do, K.H., Radiographic and CT features of viral pneumonia (2018) RadioGraphics, 38 (3), pp. 719-739; Yuan, Y., Tao, X.F., Shi, Y.X., Liu, S.Y., Chen, J.Q., Initial HRCT findings of novel influenza A (H1N1) infection (2012) Influenza Other Respir Viruses, 6 (6), pp. e114-e119; Wong, K.T., Antonio, G.E., Hui, D.S., Severe acute respiratory syndrome: Thin-section computed tomography features, temporal changes, and clinicoradiologic correlation during the convalescent period (2004) J Comput Assist Tomogr, 28 (6), pp. 790-795; Qureshi, N.R., Hien, T.T., Farrar, J., Gleeson, F.V., The radiologic manifestations of H5N1 avian influenza (2006) J Thorac Imaging, 21 (4), pp. 259-264","Shi, Y.; Department of Radiology, Shanghai Public Health Clinical Center, No. 2501 Caolang Road Jinshan District, China; email: shiyuxin@shphc.org.cn",,Radiological Society of North America Inc.,338419,,RADLA,32027573,English,Radiology,Article,Final,Open Access,Scopus,2-s2.0-85081241418,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Xu X., Yu C., Qu J., Zhang L., Jiang S., Huang D., Chen B., Zhang Z., Guan W., Ling Z., Jiang R., Hu T., Ding Y., Lin L., Gan Q., Luo L., Tang X., Liu J.",57215087553;57215089397;57215428913;57215090616;26662278600;16070296300;24400759800;55643998968;55599237100;55215409700;57215420865;57215429619;57215417268;57211979395;55212141600;9039575200;8442040100;24401436200;,Imaging and clinical features of patients with 2019 novel coronavirus SARS-CoV-2,2020,European Journal of Nuclear Medicine and Molecular Imaging,47,5,,1275,1280,,,10.1007/s00259-020-04735-9,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080906957&doi=10.1007%2fs00259-020-04735-9&partnerID=40&md5=f83a6ccb72a506f2ee3cec1255d458da,"Department of Medical Imaging Center, The First Affiliated Hospital, Jinan University, No. 613, Huangpu Road West, Tianhe District, Guangzhou, Guangdong Province 510630, China; Department of Radiology, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, No. 8, Huaying Road, Baiyun District, Guangzhou, Guangdong Province 510060, China","Xu, X., Department of Medical Imaging Center, The First Affiliated Hospital, Jinan University, No. 613, Huangpu Road West, Tianhe District, Guangzhou, Guangdong Province 510630, China; Yu, C., Department of Radiology, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, No. 8, Huaying Road, Baiyun District, Guangzhou, Guangdong Province 510060, China; Qu, J., Department of Radiology, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, No. 8, Huaying Road, Baiyun District, Guangzhou, Guangdong Province 510060, China; Zhang, L., Department of Radiology, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, No. 8, Huaying Road, Baiyun District, Guangzhou, Guangdong Province 510060, China; Jiang, S., Department of Radiology, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, No. 8, Huaying Road, Baiyun District, Guangzhou, Guangdong Province 510060, China; Huang, D., Department of Radiology, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, No. 8, Huaying Road, Baiyun District, Guangzhou, Guangdong Province 510060, China; Chen, B., Department of Radiology, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, No. 8, Huaying Road, Baiyun District, Guangzhou, Guangdong Province 510060, China; Zhang, Z., Department of Radiology, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, No. 8, Huaying Road, Baiyun District, Guangzhou, Guangdong Province 510060, China; Guan, W., Department of Radiology, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, No. 8, Huaying Road, Baiyun District, Guangzhou, Guangdong Province 510060, China; Ling, Z., Department of Radiology, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, No. 8, Huaying Road, Baiyun District, Guangzhou, Guangdong Province 510060, China; Jiang, R., Department of Radiology, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, No. 8, Huaying Road, Baiyun District, Guangzhou, Guangdong Province 510060, China; Hu, T., Department of Radiology, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, No. 8, Huaying Road, Baiyun District, Guangzhou, Guangdong Province 510060, China; Ding, Y., Department of Radiology, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, No. 8, Huaying Road, Baiyun District, Guangzhou, Guangdong Province 510060, China; Lin, L., Department of Radiology, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, No. 8, Huaying Road, Baiyun District, Guangzhou, Guangdong Province 510060, China; Gan, Q., Department of Radiology, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, No. 8, Huaying Road, Baiyun District, Guangzhou, Guangdong Province 510060, China; Luo, L., Department of Medical Imaging Center, The First Affiliated Hospital, Jinan University, No. 613, Huangpu Road West, Tianhe District, Guangzhou, Guangdong Province 510630, China; Tang, X., Department of Radiology, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, No. 8, Huaying Road, Baiyun District, Guangzhou, Guangdong Province 510060, China; Liu, J., Department of Radiology, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, No. 8, Huaying Road, Baiyun District, Guangzhou, Guangdong Province 510060, China","Background: The pneumonia caused by the 2019 novel coronavirus (SARS-CoV-2, also called 2019-nCoV) recently break out in Wuhan, China, and was named as COVID-19. With the spread of the disease, similar cases have also been confirmed in other regions of China. We aimed to report the imaging and clinical characteristics of these patients infected with SARS-CoV-2 in Guangzhou, China. Methods: All patients with laboratory-identified SARS-CoV-2 infection by real-time polymerase chain reaction (PCR) were collected between January 23, 2020, and February 4, 2020, in a designated hospital (Guangzhou Eighth People’s Hospital). This analysis included 90 patients (39 men and 51 women; median age, 50 years (age range, 18–86 years). All the included SARS-CoV-2-infected patients underwent non-contrast enhanced chest computed tomography (CT). We analyzed the clinical characteristics of the patients, as well as the distribution characteristics, pattern, morphology, and accompanying manifestations of lung lesions. In addition, after 1–6 days (mean 3.5 days), follow-up chest CT images were evaluated to assess radiological evolution. Findings: The majority of infected patients had a history of exposure in Wuhan or to infected patients and mostly presented with fever and cough. More than half of the patients presented bilateral, multifocal lung lesions, with peripheral distribution, and 53 (59%) patients had more than two lobes involved. Of all included patients, COVID-19 pneumonia presented with ground glass opacities in 65 (72%), consolidation in 12 (13%), crazy paving pattern in 11 (12%), interlobular thickening in 33 (37%), adjacent pleura thickening in 50 (56%), and linear opacities combined in 55 (61%). Pleural effusion, pericardial effusion, and lymphadenopathy were uncommon findings. In addition, baseline chest CT did not show any abnormalities in 21 patients (23%), but 3 patients presented bilateral ground glass opacities on the second CT after 3–4 days. Conclusion: SARS-CoV-2 infection can be confirmed based on the patient’s history, clinical manifestations, imaging characteristics, and laboratory tests. Chest CT examination plays an important role in the initial diagnosis of the novel coronavirus pneumonia. Multiple patchy ground glass opacities in bilateral multiple lobular with periphery distribution are typical chest CT imaging features of the COVID-19 pneumonia. © 2020, Springer-Verlag GmbH Germany, part of Springer Nature.",2019 novel coronavirus pneumonia; Computed tomography; COVID-19; Ground glass opacification; Imaging features; Infection; SARS-CoV-2,,"Richman, D.D., Whitley, R.J., Hayden, F.G., (2016) Clinical Virology, , Washington, ASM Press; Su, S., Wong, G., Shi, W., Liu, J., Lai, A.C.K., Zhou, J., Epidemiology, genetic recombination, and pathogenesis of coronaviruses (2016) Trends Microbiol, 24, pp. 490-502; Cui, J., Li, F., Shi, Z.L., Origin and evolution of pathogenic coronaviruses (2019) Nat Rev Microbiol, 17, pp. 181-192; Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382, pp. 727-733. , https://doi.org/10.1056/NEJMoa2001017, –,., https://doi.org/10.1056/NEJMoa2001017; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506. , https://doi.org/10.1016/S0140-6736(20)30183-5, –,., https://doi.org/10.1016/S0140-6736(20)30183-5; Chan, J.F., Yuan, S., Kok, K.H., To, K.K., Chu, H., Yang, J., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, 395, pp. 514-523. , https://doi.org/10.1016/S0140-6736(20)30154-9, –,., https://doi.org/10.1016/S0140-6736(20)30154-9; Hansell, D.M., Bankier, A.A., MacMahon, H., McLoud, T.C., Müller, N.L., Remy, J., Fleischner Society: glossary of terms for thoracic imaging (2008) Radiology., 246, pp. 697-722; Chung, M., Bernheim, A., Mei, X., Zhang, N., Huang, M., Zeng, X., CT imaging features of 2019 novel coronavirus (2019-nCoV) (2020) Radiology, , https://doi.org/10.1148/radiol.2020200230; Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395, pp. 507-513. , https://doi.org/10.1016/S0140-6736(20)30211-7, –,., https://doi.org/10.1016/S0140-6736(20)30211-7; Xu, X., Chen, P., Wang, J., Feng, J., Zhou, H., Li, X., Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for the risk of human transmission (2020) Sci China Life Sci, , https://doi.org/10.1007/s11427-020-1637-5; Chong, S., Kim, T.S., Cho, E.Y., Herpes simplex virus pneumonia: high-resolution CT findings (2010) Br J Radiol, 83, pp. 585-589; Koo, H.J., Lim, S., Choe, J., Choi, S.H., Sung, H., Do, K.H., Radiographic and CT features of viral pneumonia (2018) Radiographics., 38, pp. 719-739; Ooi, G.C., Daqing, M., SARS: radiological features (2003) Respirology., 8, pp. S15-S19; Das, K.M., Lee, E.Y., Langer, R.D., Larsson, S.G., Middle East respiratory syndrome coronavirus: what does a radiologist need to know? (2016) AJR Am J Roentgenol, 206, pp. 1193-1201; Heymann, D.L., Data sharing and outbreaks: best practice exemplified (2020) Lancet, 395, pp. 469-470. , https://doi.org/10.1016/S0140-6736(20)30184-7, –,., https://doi.org/10.1016/S0140-6736(20)30184-7","Luo, L.; Department of Medical Imaging Center, The First Affiliated Hospital, Jinan University, No. 613, Huangpu Road West, Tianhe District, China; email: tluolp@jnu.edu.cn",,Springer,16197070,,EJNMA,32107577,English,Eur. J. Nucl. Med. Mol. Imaging,Article,Final,Open Access,Scopus,2-s2.0-85080906957,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Suzuki T., Otake Y., Uchimoto S., Hasebe A., Goto Y.",55549701900;57214820114;57214821026;56237846300;57214818442;,Genomic characterization and phylogenetic classification of bovine coronaviruses through whole genome sequence analysis,2020,Viruses,12,2,183,,,,,10.3390/v12020183,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079209615&doi=10.3390%2fv12020183&partnerID=40&md5=53da8cf70b95bad95a4b9749b66b61c8,"Division of Viral Disease and Epidemiology, National Institute of Animal Health, National Agriculture and Food Research Organization, Tsukuba, Ibaraki, 3050856, Japan; Central Tochigi Prefectural Livestock Health and Hygiene Center, Utsunomiya, Tochigi, 3210905, Japan; Shiga Prefectural Livestock Health and Hygiene Center, Omihachiman, Shiga, 5230813, Japan; Central Gifu Prefectural Livestock Health and Hygiene Center, Gifu, 5011112, Japan; Central Iwate Prefectural Livestock Health and Hygiene Center, Takizawa, Iwate, 0200605, Japan","Suzuki, T., Division of Viral Disease and Epidemiology, National Institute of Animal Health, National Agriculture and Food Research Organization, Tsukuba, Ibaraki, 3050856, Japan; Otake, Y., Central Tochigi Prefectural Livestock Health and Hygiene Center, Utsunomiya, Tochigi, 3210905, Japan; Uchimoto, S., Shiga Prefectural Livestock Health and Hygiene Center, Omihachiman, Shiga, 5230813, Japan; Hasebe, A., Central Gifu Prefectural Livestock Health and Hygiene Center, Gifu, 5011112, Japan; Goto, Y., Central Iwate Prefectural Livestock Health and Hygiene Center, Takizawa, Iwate, 0200605, Japan","Bovine coronavirus (BCoV) is zoonotically transmissible among species, since BCoV-like viruses have been detected in wild ruminants and humans. BCoV causing enteric and respiratory disease is widespread in cattle farms worldwide; however, limited information is available regarding the molecular characterization of BCoV because of its large genome size, despite its significant economic impact. This study aimed to better understand the genomic characterization and evolutionary dynamics of BCoV via comparative sequence and phylogenetic analyses through whole genome sequence analysis using 67 BCoV isolates collected throughout Japan from 2006 to 2017. On comparing the genomic sequences of the 67 BCoVs, genetic variations were detected in 5 of 10 open reading frames (ORFs) in the BCoV genome. Phylogenetic analysis using whole genomes from the 67 Japanese BCoV isolates in addition to those from 16 reference BCoV strains, revealed the existence of two major genotypes (classical and US wild ruminant genotypes). All Japanese BCoV isolates originated from the US wild ruminant genotype, and they tended to form the same clusters based on the year and farm of collection, not the disease type. Phylogenetic trees on hemagglutinin-esterase protein (HE), spike glycoprotein (S), nucleocapsid protein (N) genes and ORF1 revealed clusters similar to that on whole genome, suggesting that the evolution of BCoVs may be closely associated with variations in these genes. Furthermore, phylogenetic analysis of BCoV S genes including those of European and Asian BCoVs and human enteric coronavirus along with the Japanese BCoVs revealed that BCoVs differentiated into two major types (European and American types). Moreover, the European and American types were divided into eleven and three genotypes, respectively. Our analysis also demonstrated that BCoVs with different genotypes periodically emerged and predominantly circulated within the country. These findings provide useful information to elucidate the detailed molecular characterization of BCoVs, which have spread worldwide. Further genomic analyses of BCoV are essential to deepen the understanding of the evolution of this virus. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).",Bovine coronavirus; Genotype classification; Phylogenetic analysis; Spike protein; Whole genome,M protein; nucleocapsid protein; virus RNA; virus spike protein; Article; Bovine coronavirus; controlled study; diarrhea; feces analysis; genome analysis; HRT-18 cell line; human; human cell; maximum likelihood method; nonhuman; nose smear; nucleotide sequence; open reading frame; phylogeny; respiratory tract disease; reverse transcription polymerase chain reaction; RNA extraction; ruminant; sequence alignment; sequence analysis; virus genome; virus isolation; whole genome sequencing,"Alenius, S., Niskanen, R., Juntti, N., Larsson, B., Bovine coronavirus as the causative agent of winter dysentery: Serological evidence (1991) Acta Vet. Scand., 32, pp. 163-170; Lathrop, S.L., Wittum, T.E., Loerch, S.C., Perino, L.J., Saif, L.J., Antibody titers against bovine coronavirus and shedding of the virus via the respiratory tract in feedlot cattle (2000) Am. J. Vet. Res., 61, pp. 1057-1061. , CrossRef PubMed; Mebus, C.A., Stair, E.L., Rhodes, M.B., Twiehaus, M.J., Neonatal calf diarrhea; propagation, attenuation, and characteristics of coronavirus-like agent (1973) Am. J. Vet. Res., 34, pp. 145-150; Saif, L.J., Brock, K.V., Redman, D.R., Kohler, E.M., Winter dysentery in dairy herds: Electron microscopic and serological evidence for an association with coronavirus infection (1991) Vet. Rec., 128, pp. 447-449. , CrossRef PubMed; Storz, J., Purdy, W., Lin, X., Burrell, M., Truax, R.E., Briggs, R.E., Frank, G.H., Loan, R.W., Isolation of respiratory bovine coronavirus, other cytocidal viruses, and Pasteurella spp. From cattle involved in two natural outbreaks of shipping fever (2000) J. Am. Vet. Med. Assoc., 216, pp. 1599-1604. , CrossRef PubMed; Clark, M.A., Bovine coronavirus (1993) Br. Vet. J., 149, pp. 51-70; Saif, L.J., Bovine respiratory coronavirus (2010) Vet. Clin. N. Am. Food Anim. Pract., 26, pp. 349-364; Hasoksuz, M., Lathrop, S., Al-dubaib, M.A., Lewis, P., Saif, L.J., Antigenic variation among bovine coronavirus (BECV) and bovine respiratory coronavirus (BRCV) detected using monoclonal antibodies (1999) Arch. Virol., 144, pp. 2441-2447; Kourtesis, A.B., Gélinas, A.M., Dea, S., Genomic and antigenic variation of the HE glycoprotein of bovine coronaviruses associated with neonatal calf diarrhea and winter dysentery (2001) Arch. Virol., 146, pp. 1219-1230; Tsunemitsu, H., Saif, L.J., Antigenic and biological comparisons of bovine coronaviruses derived from neonatal calf diarrhea and winter dysentery of adult cattle (1995) Arch. Virol., 140, pp. 1303-1311; Cavanagh, D., Nidovirales: A new order copmprising Coronaviridae and Arteriviridae (1997) Arch. 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Rec., 142, pp. 385-391; Park, S.J., Lim, G.K., Park, S.I., Kim, H.H., Koh, H.B., Cho, K.O., Detection and molecular characterization of calf diarrhoea bovine coronaviruses circulating in South Korea during 2004–2005 (2007) Zoonoses Public Health, 54, pp. 223-230; Alekseev, K.P., Valsova, A.N., Jung, K., Hosoksuz, M., Zhang, X., Halpin, R., Wang, S., Saif, L.J., Bovine-like coronaviruses isolated from four species of captive wild ruminants are homologous to bovine coronavirus based on complete genomic sequences (2008) J. 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Virol., 44, pp. 152-161; Bidokhi, M.R., Tråvén, M., Krishna, N.K., Munir, M., Belák, S., Alenius, S., Cortey, M., Evolutionary dynamics of bovine coronaviruses: Natural selection pattern of the spike gene implies adaptive evolution of the strains (2013) J. Gen. Virol., 94, pp. 2036-2049; Chouljenko, V.N., Kousoulas, K.G., Lin, X., Storz, S., Nucleotide and predicted amino acid sequences of all genes encoded by the 3’ genomic portion (9.5Kb) of respiratory bovine coronaviruses and comparisons among respiratory and enteric coronaviruses (1998) Virus Genes, 17, pp. 33-42; Liu, L., Hägglund, S., Hakhverdyan, M., Alenius, S., Larsen, L.E., Belák, S., Molecular epidemiology of bovine coronavirus on the basis of comparative analyses of the S gene (2006) J. Clin. 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Evol., 35, pp. 1547-1549. , CrossRef PubMed; Matthijnssens, J., Ciarlet, M., Heiman, E., Arijs, I., Delbeke, T., McDonald, S.M., Palombo, E.A., Patton, J.T., Full genome-based classification of rotaviruses reveals a common origin between human Wa-like and porcine rotavirus strains and human DS-1-like and bovine rotavirus strains (2008) J. Virol., 82, pp. 3204-3219. , CrossRef PubMed; Matthijnssens, J., Ciarlet, M., Rahman, M., Attoui, H., Bányai, K., Estes, M.K., Gentsch, J.R., Martella, V., Recommendations for the classification of group A rotaviruses using all 11 genomic RNA segments (2008) Arch. Virol., 153, pp. 1621-1629. , CrossRef PubMed; Suzuki, T., Murakami, S., Takahashi, O., Kodera, A., Masuda, T., Itoh, S., Miyazaki, A., Tsutsui, T., Molecular characterization of pig epidemic diarrhoea viruses isolated in Japan from 2013 to 2014 (2015) Infect. Genet. Evol., 36, pp. 363-368; Suzuki, T., Shibahara, T., Imai, N., Yamamoto, T., Ohashi, S., Genetic characterization and pathogenicity of Japanese porcine deltacoronavirus (2018) Infect. Genet. Evol., 61, pp. 176-182. , CrossRef PubMed; Lai, M.M., Cavanagh, D., The molecular biology of coronaviruses (1997) Adv. Virus Res., 48, pp. 1-100; McBride, R., van Zyl, M., Fielding, R., The coronavirus nucleocapsid is a multifunctional protein (2014) Viruses, 6, pp. 2991-3018","Suzuki, T.; Division of Viral Disease and Epidemiology, National Institute of Animal Health, National Agriculture and Food Research OrganizationJapan; email: suzuki106@affrc.go.jp",,MDPI AG,19994915,,,32041103,English,Viruses,Article,Final,Open Access,Scopus,2-s2.0-85079209615,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Gao P., Zhang H., Wu Z., Wang J.",56602199600;57116845000;57215588344;57215697968;,Visualising the expansion and spread of coronavirus disease 2019 by cartograms,2020,Environment and Planning A,,,,,,,,10.1177/0308518X20910162,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081647278&doi=10.1177%2f0308518X20910162&partnerID=40&md5=b27b05ac653f503cb909ce340b06b843,"State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University, Faculty of Geographical Science, Beijing Normal University, China; Faculty of Geosciences and Environmental Engineering, Southwest Jiaotong University, China; Department of Land Surveying and Geo-Informatics, The Hong Kong Polytechnic University, Hong Kong; Faculty of Geosciences and Environmental Engineering, Southwest Jiaotong University, China","Gao, P., State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University, Faculty of Geographical Science, Beijing Normal University, China; Zhang, H., Faculty of Geosciences and Environmental Engineering, Southwest Jiaotong University, China; Wu, Z., Faculty of Geosciences and Environmental Engineering, Southwest Jiaotong University, China; Wang, J., Department of Land Surveying and Geo-Informatics, The Hong Kong Polytechnic University, Hong Kong, Faculty of Geosciences and Environmental Engineering, Southwest Jiaotong University, China","Coronavirus disease 2019 (COVID-19) has emerged as a growing focus of global attention and a critical factor in public-health decision making. Towards fighting the COVID-19 outbreak, countries worldwide and international organisations have taken various actions, including promoting the transparency of and public access to disease data. In such public communications, maps have played an important role in that a map is worth a thousand words. Most of these have taken the form of a choropleth map. Here, we propose employing cartograms to visualise both the expansion and spread of COVID-19. We designed a combination of six circular cartograms containing the data of confirmed cases every 48 hours from 24 January to 3 February 2020. Such a design conveys both spatial and temporal information more intuitively and efficiently, so it can be expected to facilitate better public participation in the fight against COVID-19. © The Author(s) 2020.",Cartogram; graphic; visualisation,,"Dorling, D., (1996) Area Cartograms: Their Use and Creation, , Norwich, University of East Anglia; Gao, P.C., Li, Z.L., Qin, Z., Usability of value-by-alpha maps compared to area cartograms and proportional symbol maps (2019) Journal of Spatial Science, 64 (2), pp. 239-255; Harrower, M., Brewer, C.A., ColorBrewer.org: an online tool for selecting colour schemes for maps (2003) The Cartographic Journal, 40 (1), pp. 27-37; (2020), https://www.who.int/emergencies/diseases/novel-coronavirus-2019, (accessed 29 January 2020","Zhang, H.; Faculty of Geosciences and Environmental Engineering, Southwest Jiaotong UniversityChina; email: zhangh2011@swjtu.edu.cn",,SAGE Publications Ltd,0308518X,,,,English,Environ. Plann. A,Article,Article in Press,Open Access,Scopus,2-s2.0-85081647278,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Rothan H.A., Byrareddy S.N.",37065081700;57211770396;,The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak,2020,Journal of Autoimmunity,,,102433,,,,,10.1016/j.jaut.2020.102433,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080089137&doi=10.1016%2fj.jaut.2020.102433&partnerID=40&md5=3b060ba0dd8e028411c8f35ed85e6db9,"Department of Biology, College of Arts and Sciences, Georgia State University, Atlanta, GA, United States; Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Centre, Omaha, NE, United States; Department of Genetics, Cell Biology and Anatomy, Omaha, NE, United States; Department of Biochemistry and Molecular Biology, University of Nebraska Medical Centre, Omaha, NE, United States","Rothan, H.A., Department of Biology, College of Arts and Sciences, Georgia State University, Atlanta, GA, United States; Byrareddy, S.N., Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Centre, Omaha, NE, United States, Department of Genetics, Cell Biology and Anatomy, Omaha, NE, United States, Department of Biochemistry and Molecular Biology, University of Nebraska Medical Centre, Omaha, NE, United States","Coronavirus disease (COVID-19) is caused by SARS-COV2 and represents the causative agent of a potentially fatal disease that is of great global public health concern. Based on the large number of infected people that were exposed to the wet animal market in Wuhan City, China, it is suggested that this is likely the zoonotic origin of COVID-19. Person-to-person transmission of COVID-19 infection led to the isolation of patients that were subsequently administered a variety of treatments. Extensive measures to reduce person-to-person transmission of COVID-19 have been implemented to control the current outbreak. Special attention and efforts to protect or reduce transmission should be applied in susceptible populations including children, health care providers, and elderly people. In this review, we highlights the symptoms, epidemiology, transmission, pathogenesis, phylogenetic analysis and future directions to control the spread of this fatal disease. © 2020 Elsevier Ltd",Coronavirus; COVID-19; Pathogenesis; Pneumonia; Wuhan city,,"Bogoch, Watts, A., Thomas-Bachli, A., Huber, C., Kraemer, M.U.G., Khan, K., Pneumonia of unknown etiology in wuhan, China: potential for international spread via commercial air travel (2020) J. Trav. Med.; Lu, H., Stratton, C.W., Tang, Y.W., Outbreak of pneumonia of unknown etiology in wuhan China: the mystery and the miracle (2020) J. Med. Virol., 92 (4), pp. 401-402; Zhao, S., Lin, Q., Ran, J., Musa, S.S., Yang, G., Wang, W., Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: a data-driven analysis in the early phase of the outbreak (2020) Int. J. Infect. Dis. : IJID : Off. Publ. Int. Soc. Infect. 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Med., 9; Bassetti, M., Vena, A., Roberto Giacobbe, D., The Novel Chinese Coronavirus (2019-nCoV) Infections: challenges for fighting the storm (2020) Eur. J. Clin. Invest.; Holshue, M.L., DeBolt, C., Lindquist, S., Lofy, K.H., Wiesman, J., Bruce, H., First case of 2019 novel coronavirus in the United States (2020) N. Engl. J. Med.; Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Early transmission dynamics in wuhan, China, of novel coronavirus-infected pneumonia (2020) N. Engl. J. Med.; Carlos, W.G., Dela Cruz, C.S., Cao, B., Pasnick, S., Jamil, S., Novel wuhan (2019-nCoV) coronavirus (2020) Am. J. Respir. Crit. Care Med., 201 (4), pp. 7-8; Lei, J., Li, J., Li, X., Qi, X., CT imaging of the 2019 novel coronavirus (2019-nCoV) pneumonia (2020) Radiology, p. 200236; Assiri, A., Al-Tawfiq, J.A., Al-Rabeeah, A.A., Al-Rabiah, F.A., Al-Hajjar, S., Al-Barrak, A., Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study (2013) Lancet Infect. Dis., 13, pp. 752-761; Lee, N., Hui, D., Wu, A., Chan, P., Cameron, P., Joynt, G.M., A major outbreak of severe acute respiratory syndrome in Hong Kong (2003) N. Engl. J. Med., 348, pp. 1986-1994; Phan, L.T., Nguyen, T.V., Luong, Q.C., Nguyen, T.V., Nguyen, H.T., Le, H.Q., Importation and human-to-human transmission of a novel coronavirus in Vietnam (2020) N. Engl. J. Med.; Ji, W., Wang, W., Zhao, X., Zai, J., Li, X., Homologous recombination within the spike glycoprotein of the newly identified coronavirus may boost cross-species transmission from snake to human (2020) J. Med. Virol., 92 (4), pp. 433-440; Lu, R., Zhao, X., Li, J., Niu, P., Yang, B., Wu, H., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet, 395 (10224), pp. 565-574; Wan, Y., Shang, J., Graham, R., Baric, R.S., Li, F., Receptor recognition by novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS (2020) J. Virol.; Wu, P., Hao, X., Lau, E.H.Y., Wong, J.Y., Leung, K.S.M., Wu, J.T., Real-time tentative assessment of the epidemiological characteristics of novel coronavirus infections in Wuhan, China, as at 22 January 2020 (2020) Euro Surveill., 25; Jaimes, J.A., Millet, J.K., Stout, A.E., Andre, N.M., Whittaker, G.R., A tale of two viruses: the distinct spike glycoproteins of feline coronaviruses (2020) Viruses, 12; Hui, D.S., IA, E., Madani, T.A., Ntoumi, F., Kock, R., Dar, O., The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health - the latest 2019 novel coronavirus outbreak in Wuhan, China (2020) Int. J. Infect. Dis., 91, pp. 264-266; Cui, J., Li, F., Shi, Z.L., Origin and evolution of pathogenic coronaviruses (2019) Nat. Rev. Microbiol., 17, pp. 181-192; Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., A novel coronavirus from patients with pneumonia in China (2019) N. Engl. J. Med., 382, pp. 727-733. , 2020; Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395 (10223), pp. 507-513; Wang, M., Cao, R., Zhang, L., Yang, X., Liu, J., Xu, M., Remdesivir and Chloroquine Effectively Inhibit the Recently Emerged Novel Coronavirus (2019-nCoV) in Vitro (2020), Cell research; Toots, M., Yoon, J.J., Cox, R.M., Hart, M., Sticher, Z.M., Makhsous, N., Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia (2019) Sci. Transl. Med., p. 11; Jin, Y.H., Cai, L., Cheng, Z.S., Cheng, H., Deng, T., Fan, Y.P., A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version) (2020) Mil. Med. Res., 7, p. 4","Byrareddy, S.N.; Department of Pharmacology and Experimental Neuroscience Durham Research Center, 8047 985880 Nebraska Medical Center OmahaUnited States; email: sid.byrareddy@unmc.edu",,Academic Press,8968411,,JOAUE,,English,J. Autoimmun.,Review,Article in Press,Open Access,Scopus,2-s2.0-85080089137,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Chen Z.-M., Fu J.-F., Shu Q., Chen Y.-H., Hua C.-Z., Li F.-B., Lin R., Tang L.-F., Wang T.-L., Wang W., Wang Y.-S., Xu W.-Z., Yang Z.-H., Ye S., Yuan T.-M., Zhang C.-M., Zhang Y.-Y.",36631890700;8429908700;57210698907;57216112018;8286914700;57214912817;57214916948;35312719700;57215036731;57215073105;24588063700;57207174517;57215297783;57214933724;57214937478;23391480500;57214916717;,Diagnosis and treatment recommendations for pediatric respiratory infection caused by the 2019 novel coronavirus,2020,World Journal of Pediatrics,,,,,,,5,10.1007/s12519-020-00345-5,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079228854&doi=10.1007%2fs12519-020-00345-5&partnerID=40&md5=f439921c887d1666adac2719ea16657e,"Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children’s Regional Medical Center, Hangzhou, 310052, China","Chen, Z.-M., Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children’s Regional Medical Center, Hangzhou, 310052, China; Fu, J.-F., Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children’s Regional Medical Center, Hangzhou, 310052, China; Shu, Q., Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children’s Regional Medical Center, Hangzhou, 310052, China; Chen, Y.-H., Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children’s Regional Medical Center, Hangzhou, 310052, China; Hua, C.-Z., Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children’s Regional Medical Center, Hangzhou, 310052, China; Li, F.-B., Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children’s Regional Medical Center, Hangzhou, 310052, China; Lin, R., Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children’s Regional Medical Center, Hangzhou, 310052, China; Tang, L.-F., Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children’s Regional Medical Center, Hangzhou, 310052, China; Wang, T.-L., Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children’s Regional Medical Center, Hangzhou, 310052, China; Wang, W., Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children’s Regional Medical Center, Hangzhou, 310052, China; Wang, Y.-S., Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children’s Regional Medical Center, Hangzhou, 310052, China; Xu, W.-Z., Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children’s Regional Medical Center, Hangzhou, 310052, China; Yang, Z.-H., Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children’s Regional Medical Center, Hangzhou, 310052, China; Ye, S., Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children’s Regional Medical Center, Hangzhou, 310052, China; Yuan, T.-M., Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children’s Regional Medical Center, Hangzhou, 310052, China; Zhang, C.-M., Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children’s Regional Medical Center, Hangzhou, 310052, China; Zhang, Y.-Y., Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children’s Regional Medical Center, Hangzhou, 310052, China","Since December 2019, an epidemic caused by novel coronavirus (2019-nCoV) infection has occurred unexpectedly in China. As of 8 pm, 31 January 2020, more than 20 pediatric cases have been reported in China. Of these cases, ten patients were identified in Zhejiang Province, with an age of onset ranging from 112 days to 17 years. Following the latest National recommendations for diagnosis and treatment of pneumonia caused by 2019-nCoV (the 4th edition) and current status of clinical practice in Zhejiang Province, recommendations for the diagnosis and treatment of respiratory infection caused by 2019-nCoV for children were drafted by the National Clinical Research Center for Child Health, the National Children’s Regional Medical Center, Children’s Hospital, Zhejiang University School of Medicine to further standardize the protocol for diagnosis and treatment of respiratory infection in children caused by 2019-nCoV. © 2020, Children's Hospital, Zhejiang University School of Medicine.",Child; Diagnosis; New coronavirus; Recommendation; Respiratory infection; Treatment,,"Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., Zhao, X., Tan, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med; Chan, J.F., Yuan, S., Kok, K.H., To, K.K., Chu, H., Yang, J., Xing, F., Yuen, K.Y., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet; https://www.nhc.gov.cn/xcs/zhengcwj/202001/4294563ed35b43209b31739bd0785e67/files/7a9309111267475a99d4306962c8bf78.pdf, National Recommendations for Diagnosis and Treatment of pneumonia caused by 2019-nCoV (the 4th edition). National Health Commission and National Administrative Office of Chinese Tradition Medicine, Access 29 Jan 2020; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet; Stanley, P., Another decade, another coronavirus (2019) N Engl J Med; Ma, X.J., Wang, L.N., Wang, L.B., Wang, X.F., Fang, F., Deng, L., Diangosis and treatment guideline of community acquired pneumonia in children (2019) Chin Clin Infect Dis J., 12, pp. 6-13; Chu, C.M., Role of Lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings (2004) Thorax, 59, pp. 252-256. , COI: 1:STN:280:DC%2BD2c%2Fps1anuw%3D%3D; Arabi, Y.M., Alothman, A., Balkhy, H.H., Al-Dawood, A., AlJohani, S., Al Harbi, S., Treatment of Middle East respiratory syndrome with a combination of lopinavir–ritonavir and interferon-β1b (MIRACLE trial): study protocol for a randomized controlled trial (2018) Trials, 19, p. 81; Lu, Q., Wang, X.F., Qiang, Y., Li, X.M., Zhang, H.L., Wang, L.N., Expert consensus on the diagnosis and treatment of viral pneumonia in children (2019) (2019) Zhongguo Shi Yong Er Ke Za Zhi, 34, pp. 801-807. , (in Chinese; Arabi, Y.M., Mandourah, Y., Al-Hameed, F., Sindi, A.A., Almekhlafi, G.A., Hussein, M.A., Corticosteroid therapy for critically ill patients with Middle East respiratory syndrome (2018) Am J Respir Crit Care Med, 197, pp. 757-767; (2020) Clinical Management of Severe Acute Respiratory Infection When Novel Coronavirus (Ncov) Infection is Suspected, , https://www.who.int/docs/default-source/coronaviruse/clinical-management-of-novel-cov.pdf?sfvrsn=bc7da517_2, Jan 11, Accessed 30 Jan 30 2020; Diagnosis and treatment guideline of community acquired pneumonia in children (2013 the First part) (2013) Zhonghua Er Ke Za Zhi, 51, pp. 745-752; Wang, X.F., Deng, L., Liu, J.R., Liu, C.F., Liu, E.M., Liu, H.W., Guidelines for the diagnosis and treatment of adenovirus pneumonia in children (2019 edition) (2019) Chin J Cli Infect Dis., 12, pp. 161-166. , (in Chinese; Consensus of extracorporeal membrane oxygenation support for acute fulminant myocarditis in children (2020) Chin J Emerg Med., 29, pp. 5-10. , (in Chinese","Fu, J.-F.; Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children’s Regional Medical CenterChina; email: fjf68@zju.edu.cn",,Institute of Pediatrics of Zhejiang University,17088569,,,32026148,English,World J. Pediatr.,Review,Article in Press,Open Access,Scopus,2-s2.0-85079228854,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Jaimes J.A., Millet J.K., Stout A.E., André N.M., Whittaker G.R.",55173670700;55217392700;57204645460;57200535889;7006825143;,A tale of two viruses: The distinct spike glycoproteins of feline coronaviruses,2020,Viruses,12,1,83,,,,1,10.3390/v12010083,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077896560&doi=10.3390%2fv12010083&partnerID=40&md5=0f99b9a31ba1a6db6bba3eb8ebe88a86,"Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, United States; Virologie et Immunologie Moléculaires, INRAE, Université Paris-Saclay, Jouy-en-Josas, 78352, France","Jaimes, J.A., Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, United States; Millet, J.K., Virologie et Immunologie Moléculaires, INRAE, Université Paris-Saclay, Jouy-en-Josas, 78352, France; Stout, A.E., Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, United States; André, N.M., Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, United States; Whittaker, G.R., Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, United States","Feline coronavirus (FCoV) is a complex viral agent that causes a variety of clinical manifestations in cats, commonly known as feline infectious peritonitis (FIP). It is recognized that FCoV can occur in two different serotypes. However, differences in the S protein are much more than serological or antigenic variants, resulting in the effective presence of two distinct viruses. Here, we review the distinct differences in the S proteins of these viruses, which are likely to translate into distinct biological outcomes. We introduce a new concept related to the non-taxonomical classification and differentiation among FCoVs by analyzing and comparing the genetic, structural, and functional characteristics of FCoV and the FCoV S protein among the two serotypes and FCoV biotypes. Based on our analysis, we suggest that our understanding of FIP needs to consider whether the presence of these two distinct viruses has implications in clinical settings. © 2020 by the authors.",Feline coronavirus; Feline infectious peritonitis; Genetic characterization; Serotype; Spike protein,angiotensin converting enzyme 2; coronavirus spike glycoprotein; dipeptidyl peptidase IV; microsomal aminopeptidase; polyprotein; virus fusion protein; vitronectin; Alphacoronavirus; Alphacoronavirus 1; amino acid sequence; Betacoronavirus; biotype; cat; electron tomography; Feline coronavirus; feline infectious peritonitis; Gammacoronavirus; gene deletion; gene mutation; genetic recombination; genome analysis; Middle East respiratory syndrome coronavirus; nonhuman; open reading frame; phylogeny; Porcine respiratory coronavirus; receptor binding; Review; SARS coronavirus; serotype; virus isolation; virus replication; virus transmission,"Masters, P.S., Perlman, S., Coronaviridae (2013) Fields Virology, 1, pp. 825-858. , 6th ed.; Knipe, D.M., Howley, M., Eds.; Lippincot Williams & Wilkins: Philadelphia, PA, USA; Millet, J.K., Whittaker, G.R., Host cell proteases: Critical determinants of coronavirus tropism and pathogenesis (2015) Virus Res, 202, pp. 120-134; Song, Z., Xu, Y., Bao, L., Zhang, L., Yu, P., Qu, Y., Zhu, H., Qin, C., From SARS to MERS, thrusting coronaviruses into the spotlight (2019) Viruses, 11, p. 59; Zumla, A., Alagaili, A.N., Cotten, M., Azhar, E.I., Infectious diseases epidemic threats and mass gatherings: Refocusing global attention on the continuing spread of the Middle East Respiratory syndrome coronavirus (MERS-CoV) (2016) BMC Med, 14, p. 132; Whittaker, G.R., Coronaviridae (2017) Fenner’S Veterinary Virology, pp. 435-462. , 5th ed.; MacLachlan, N.J., Dubovi, E.J., Eds.; Academic Press: London, UK; Kipar, A., Meli, M.L., Feline infectious peritonitis: Still an enigma? (2014) Vet. Pathol., 51, pp. 505-526; Wolfe, L.G., Griesemer, R.A., Feline infectious peritonitis (1966) Pathol. Vet., 3, pp. 255-270; Pedersen, N.C., A review of feline infectious peritonitis virus infection: 1963–2008 (2009) J. Feline Med. Surg., 11, pp. 225-258; Pedersen, N.C., An update on feline infectious peritonitis: Virology and immunopathogenesis (2014) Vet. J., 201, pp. 123-132; André, N.M., Cossic, B., Davies, E., Miller, A.D., Whittaker, G.R., Distinct mutation in the feline coronavirus spike protein cleavage activation site in a cat with feline infectious peritonitis-associated meningoencephalomyelitis (2019) J. Feline Med. Surg. Open Rep., 5; Chang, H.W., Egberink, H.F., Halpin, R., Spiro, D.J., Rottier, P.J., Spike protein fusion peptide and feline coronavirus virulence (2012) Emerg. Infect. Dis., 18, pp. 1089-1095; Licitra, B.N., Millet, J.K., Regan, A.D., Hamilton, B.S., Rinaldi, V.D., Duhamel, G.E., Whittaker, G.R., Mutation in spike protein cleavage site and pathogenesis of feline coronavirus (2013) Emerg. Infect. Dis., 19, pp. 1066-1073; Porter, E., Tasker, S., Day, M.J., Harley, R., Kipar, A., Siddell, S.G., Helps, C.R., Amino acid changes in the spike protein of feline coronavirus correlate with systemic spread of virus from the intestine and not with feline infectious peritonitis (2014) Vet. Res., 45, p. 49; Chang, H.W., de Groot, R.J., Egberink, H.F., Rottier, P.J., Feline infectious peritonitis: Insights into feline coronavirus pathobiogenesis and epidemiology based on genetic analysis of the viral 3c gene (2010) J. Gen. Virol., 91, pp. 415-420; Perera, K.D., Rathnayake, A.D., Liu, H., Pedersen, N.C., Groutas, W.C., Chang, K.O., Kim, Y., Characterization of amino acid substitutions in feline coronavirus 3C-like protease from a cat with feline infectious peritonitis treated with a protease inhibitor (2019) Vet. Microbiol., 237, p. 108398; Murphy, B.G., Perron, M., Murakami, E., Bauer, K., Park, Y., Eckstrand, C., Liepnieks, M., Pedersen, N.C., The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies (2018) Vet. Microbiol., 219, pp. 226-233; Kim, Y., Liu, H., Galasiti Kankanamalage, A.C., Weerasekara, S., Hua, D.H., Groutas, W.C., Chang, K.-O., Pedersen, N.C., Reversal of the progression of fatal coronavirus infection in cats by a broad-spectrum coronavirus protease inhibitor (2016) PLoS Pathog, 12; Pedersen, N.C., Perron, M., Bannasch, M., Montgomery, E., Murakami, E., Liepnieks, M., Liu, H., Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis (2019) J. Feline Med. Surg., 21, pp. 271-281; Pedersen, N.C., Ward, J., Mengeling, W.L., Antigenic relationship of the feline infectious peritonitis virus to coronaviruses of other species (1978) Arch. Virol., 58, pp. 45-53; Corapi, W.V., Olsen, C.W., Scott, F.W., Monoclonal antibody analysis of neutralization and antibody-dependent enhancement of feline infectious peritonitis virus (1992) J. Virol., 66, pp. 6695-6705; Hohdatsu, T., Okada, S., Koyama, H., Characterization of monoclonal antibodies against feline infectious peritonitis virus type II and antigenic relationship between feline, porcine, and canine coronaviruses (1991) Arch. Virol., 117, pp. 85-95; Pedersen, N.C., Black, J.W., Boyle, J.F., Evermann, J.F., McKeirnan, A.J., Ott, R.L., Pathogenic differences between various feline coronavirus isolates (1984) Adv. Exp. Med. Biol., 173, pp. 365-380; Addie, D.D., Schaap, I.A., Nicolson, L., Jarrett, O., Persistence and transmission of natural type I feline coronavirus infection (2003) J. Gen. Virol., 84, pp. 2735-2744; Kummrow, M., Meli, M.L., Haessig, M., Goenczi, E., Poland, A., Pedersen, N.C., Hofmann-Lehmann, R., Lutz, H., Feline coronavirus serotypes 1 and 2: Seroprevalence and association with disease in Switzerland (2005) Clin. Diagn. Lab. Immunol., 12, pp. 1209-1215; Li, C., Liu, Q., Kong, F., Guo, D., Zhai, J., Su, M., Sun, D., Circulation and genetic diversity of Feline coronavirus type I and II from clinically healthy and FIP-suspected cats in China (2019) Transbound Emerg. Dis., 66, pp. 763-775; Benetka, V., Kubber-Heiss, A., Kolodziejek, J., Nowotny, N., Hofmann-Parisot, M., Mostl, K., Prevalence of feline coronavirus types I and II in cats with histopathologically verified feline infectious peritonitis (2004) Vet. Microbiol., 99, pp. 31-42; Tekes, G., Hofmann-Lehmann, R., Bank-Wolf, B., Maier, R., Thiel, H.J., Thiel, V., Chimeric feline coronaviruses that encode type II spike protein on type I genetic background display accelerated viral growth and altered receptor usage (2010) J. Virol., 84, pp. 1326-1333; Herrewegh, A.A.P.M., Smeenk, I., Horzinek, M.C., Rottier, P.J.M., de Groot, R.J., Feline coronavirus type II strains 79-1683 and 79-1146 originate from a double recombination between feline coronavirus type I and canine coronavirus (1998) J. Virol., 72, pp. 4508-4514; Whittaker, G.R., Andre, N.M., Millet, J.K., Improving virus taxonomy by recontextualizing sequence-based classification with biologically relevant data: The case of the alphacoronavirus 1 species (2018) mSphere, 3, pp. e00463-e00517; Takano, T., Endoh, M., Fukatsu, H., Sakurada, H., Doki, T., Hohdatsu, T., The cholesterol transport inhibitor U18666A inhibits type I feline coronavirus infection (2017) Antivir. Res., 145, pp. 96-102; Doki, T., Yabe, M., Takano, T., Hohdatsu, T., Differential induction of type I interferon by type I and type II feline coronaviruses in vitro (2018) Res. Vet. Sci., 120, pp. 57-62; Olsen, C.W., A review of feline infectious peritonitis virus: Molecular biology, immunopathogenesis, clinical aspects, and vaccination (1993) Vet. Microbiol., 36, pp. 1-37; Dye, C., Siddell, S.G., Genomic RNA sequence of Feline coronavirus strain FIPV WSU-79/1146 (2005) J. Gen. Virol., 86, pp. 2249-2253; Nieto-Torres, J.L., DeDiego, M.L., Verdia-Baguena, C., Jimenez-Guardeno, J.M., Regla-Nava, J.A., Fernandez-Delgado, R., Castano-Rodriguez, C., Aguilella, V.M., Severe acute respiratory syndrome coronavirus envelope protein ion channel activity promotes virus fitness and pathogenesis (2014) PLoS Pathog, 10; Jaimes, J.A., Whittaker, G.R., Feline coronavirus: Insights into viral pathogenesis based on the spike protein structure and function (2018) Virology, 517, pp. 108-121; Bosch, B.J., van der Zee, R., de Haan, C.A.M., Rottier, P.J.M., The coronavirus spike protein is a class I virus fusion protein: Structural and functional characterization of the fusion core complex (2003) J. Virol., 77, pp. 8801-8811; White, J.M., Delos, S.E., Brecher, M., Schornberg, K., Structures and mechanisms of viral membrane fusion proteins: Multiple variations on a common theme (2008) Crit. Rev. Biochem. Mol. 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Virol., 87, pp. 1209-1216; Li, W., Hulswit, R.J.G., Widjaja, I., Raj, V.S., McBride, R., Peng, W., Widagdo, W., Lang, Y., Identification of sialic acid-binding function for the Middle East respiratory syndrome coronavirus spike glycoprotein (2017) Proc. Natl. Acad. Sci. USA, 114, pp. E8508-E8517; Peng, G., Sun, D., Rajashankar, K.R., Qian, Z., Holmes, K.V., Li, F., Crystal structure of mouse coronavirus receptor-binding domain complexed with its murine receptor (2011) Proc. Natl. Acad. Sci. USA, 108, pp. 10696-10701; Tresnan, D.B., Levis, R., Holmes, K.V., Feline aminopeptidase N serves as a receptor for feline, canine, porcine, and human coronaviruses in serogroup I (1996) J. Virol., 70, pp. 8669-8674; Lu, G., Hu, Y., Wang, Q., Qi, J., Gao, F., Li, Y., Zhang, Y., Bao, J., Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26 (2013) Nature, 500, pp. 227-231; Lai, A.L., Millet, J.K., Daniel, S., Freed, J.H., Whittaker, G.R., The SARS-CoV fusion peptide forms an extended bipartite fusion platform that perturbs membrane order in a calcium-dependent manner (2017) J. Mol. Biol., 429, pp. 3875-3892; White, J.M., Whittaker, G.R., Fusion of enveloped viruses in endosomes (2016) Traffic, 17, pp. 593-614; Song, W., Gui, M., Wang, X., Xiang, Y., Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2 (2018) PLoS Pathog, 14; Walls, A.C., Xiong, X., Park, Y.J., Tortorici, M.A., Snijder, J., Quispe, J., Cameroni, E., Lanzavecchia, A., Unexpected receptor functional mimicry elucidates activation of coronavirus fusion (2019) Cell, 176, pp. 1026-1039. , e15; Walls, A.C., Tortorici, M.A., Bosch, B.J., Frenz, B., Rottier, P.J., DiMaio, F., Rey, F.A., Veesler, D., Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer (2016) Nature, 531, pp. 114-117; Walls, A.C., Tortorici, M.A., Frenz, B., Snijder, J., Li, W., Rey, F.A., DiMaio, F., Veesler, D., Glycan shield and epitope masking of a coronavirus spike protein observed by cryo-electron microscopy (2016) Nat. Struct. Mol. Biol., 23, pp. 899-905; Shang, J., Zheng, Y., Yang, Y., Liu, C., Geng, Q., Luo, C., Zhang, W., Li, F., Cryo-EM structure of infectious bronchitis coronavirus spike protein reveals structural and functional evolution of coronavirus spike proteins (2018) PLoS Pathog, 14; Shang, J., Zheng, Y., Yang, Y., Liu, C., Geng, Q., Tai, W., Du, L., Li, F., Cryo-EM structure of porcine delta coronavirus spike protein in the pre-fusion state (2018) J. Virol., 14, p. e1007236; Hohdatsu, T., Izumiya, Y., Yokoyama, Y., Kida, K., Koyama, H., Differences in virus receptor for type I and type II feline infectious peritonitis virus (1998) Arch. Virol., 143, pp. 839-850; Regan, A.D., Ousterout, D.G., Whittaker, G.R., Feline lectin activity is critical for the cellular entry of feline infectious peritonitis virus (2010) J. Virol., 84, pp. 7917-7921; Regan, A.D., Whittaker, G.R., Utilization of DC-SIGN for entry of feline coronaviruses into host cells (2008) J. Virol., 82, pp. 11992-11996; Look, A.T., Ashmun, R.A., Shapiro, L.H., Peiper, S.C., Human myeloid plasma membrane glycoprotein CD13 (gp150) is identical to aminopeptidase N (1989) J. Clin. Investig., 83, pp. 1299-1307; Dye, C., Temperton, N., Siddell, S.G., Type I feline coronavirus spike glycoprotein fails to recognize aminopeptidase N as a functional receptor on feline cell lines (2007) J. Gen. Virol., 88, pp. 1753-1760; Regan, A.D., Shraybman, R., Cohen, R.D., Whittaker, G.R., Differential role for low pH and cathepsin-mediated cleavage of the viral spike protein during entry of serotype II feline coronaviruses (2008) Vet. Microbiol., 132, pp. 235-248; Licitra, B.N., Sams, K.L., Lee, D.W., Whittaker, G.R., Feline Coronaviruses Associated with Feline Infectious Peritonitis Have Modifications to Spike Protein Activation Sites at Two Discrete Positions, , https://arxiv.org/abs/1412.4034, Available online: accessed on 10 December 2019","Whittaker, G.R.; Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell UniversityUnited States; email: grw7@cornell.edu",,MDPI AG,19994915,,,31936749,English,Viruses,Review,Final,Open Access,Scopus,2-s2.0-85077896560,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhong L., Mu L., Li J., Wang J., Yin Z., Liu D.",7201519079;57216036113;57216040794;57216041131;57216038547;57216038543;,Early Prediction of the 2019 Novel Coronavirus Outbreak in the Mainland China Based on Simple Mathematical Model,2020,IEEE Access,8,,9028194,51761,51769,,,10.1109/ACCESS.2020.2979599,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082508269&doi=10.1109%2fACCESS.2020.2979599&partnerID=40&md5=015b1feb771f72c867b76a48547e20f4,"Key Laboratory of Regional Climate-Environment for Temperate East Asia, Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing, China; College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, 518060, China; Shenzhen Research Institute, China University of Geosciences, Shenzhen, 518057, China; College of Marine Science and Technology, China University of Geosciences, Wuhan, 430074, China","Zhong, L., Key Laboratory of Regional Climate-Environment for Temperate East Asia, Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing, China; Mu, L., College of Life Sciences and Oceanography, Shenzhen University, Shenzhen, 518060, China, Shenzhen Research Institute, China University of Geosciences, Shenzhen, 518057, China; Li, J., Shenzhen Research Institute, China University of Geosciences, Shenzhen, 518057, China, College of Marine Science and Technology, China University of Geosciences, Wuhan, 430074, China; Wang, J., Shenzhen Research Institute, China University of Geosciences, Shenzhen, 518057, China, College of Marine Science and Technology, China University of Geosciences, Wuhan, 430074, China; Yin, Z., Shenzhen Research Institute, China University of Geosciences, Shenzhen, 518057, China, College of Marine Science and Technology, China University of Geosciences, Wuhan, 430074, China; Liu, D., Shenzhen Research Institute, China University of Geosciences, Shenzhen, 518057, China, College of Marine Science and Technology, China University of Geosciences, Wuhan, 430074, China","The 2019 novel coronavirus (2019-nCoV) outbreak has been treated as a Public Health Emergency of International Concern by the World Health Organization. This work made an early prediction of the 2019-nCoV outbreak in China based on a simple mathematical model and limited epidemiological data. Combing characteristics of the historical epidemic, we found part of the released data is unreasonable. Through ruling out the unreasonable data, the model predictions exhibit that the number of the cumulative 2019-nCoV cases may reach 76,000 to 230,000, with a peak of the unrecovered infectives (22,000-74,000) occurring in late February to early March. After that, the infected cases will rapidly monotonically decrease until early May to late June, when the 2019-nCoV outbreak will fade out. Strong anti-epidemic may reduce the cumulative infected cases by 40%-49%. The improvement of medical care can also lead to about one-half transmission decrease and effectively shorten the duration of the 2019-nCoV. © 2013 IEEE.",Epidemic transmission; infection rate; mathematical model; novel coronavirus; prediction; removal rate,Epidemiology; Mathematical models; Transmissions; Coronaviruses; Early prediction; Health emergencies; Infection rates; Mainland chinas; Model prediction; Removal rate; World Health Organization; Forecasting,"(2020) Wuhan Municipal Health Commission Infection Data, , http://wjw.wuhan.gov.cn/front/web/list2nd/no/710, [Online]; Kwok, K.O., Tang, A., Wei, V.W., Park, W.H., Yeoh, E.K., Riley, S., Epidemic models of contact tracing: Systematic review of transmission studies of severe acute respiratory syndrome and middle east respiratory syndrome (2019) Comput. Struct. Biotechnol. J., 17, pp. 186-194. , Jan; (2005) Emergency Committee Regarding the Outbreak of Novel Coronavirus (2019-nCoV), , https://www.who.int/news-room/detail/30-01-2020-statement-on-the-second-meeting-of-the-international-health-regulations-2005)-emergency-committee-regarding-the-outbreak-of-novel-coronavirus-(2019-ncov, World Health Organization WHO Statement on the second meeting of the International Health Regulations. Geneva, Swiss. Accessed: 2020. [Online]; (2020) World Health Organization, WHO Novel Coronavirus-Thailand (Ex-China), , http://www.who.int/csr/don/14-january-2020-novel-coronavirus-thailand/en, Geneva, Swiss. Accessed: Jan. 14 2020 [Online]; (2020) World Health Organization, WHO Novel Coronavirus-Japan (Ex-China), , http://www.who.int/csr/don/17-january-2020-novel-coronavirus-japan-ex-china/en, Geneva, Swiss. Accessed: Jan. 17 2020 [Online]; (2020) World Health Organization, WHO Novel Coronavirus-Republic of Korea (Ex-China), , http://www.who.int/csr/don/21-january-2020-novel-coronavirus-republic-of-korea-ex-china/en, Geneva, Swiss. Accessed: Jan. 21 2020 [Online]; (2020) CDC First Travel-Related Case of 2019 Novel Coronavirus Detected in United States, , https://www.cdc.gov/media/releases/2020/p0121-novel-coronavirus-travel-case.html, Centers for Disease Control and Prevention. Accessed: Jan. 21 2020 [Online]; Anderson, R.M., The pandemic of antibiotic resistance (1999) Nature Med., 5, pp. 147-149. , Feb; Koopman, J., Modeling infection transmission (2004) Annu. Rev. 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Biosci., 195 (1), pp. 23-46; Liu, J., Tang, Y., Yang, Z.R., The spread of disease with birth and death on networks (2004) J. Stat. Mech., Theory Exp., 2004 (8); C. Epidemiology: Modeling the SARS Epidemic (2003) Science, 300 (5627), pp. 1884-1885. , Dye; Lipsitch, M., Transmission dynamics and control of severe acute respiratory syndrome (2003) Science, 300 (5627), pp. 1966-1970; Han, X.N., De Vlas, S.J., Fang, L.Q., Feng, D., Cao, W.C., Habbema, J.D.F., (2009) Mathematical Modelling of SARS and Other Infectious Diseases in China: A Review, 14, pp. 92-100; Watts, D., Strogatz, S.H., Collective dynamics of 'small-world' networks (1998) Nature, 393 (6684), pp. 440-442; Pastor-Satorras, R., Vespignani, A., Epidemic spreading in scale-free networks (2001) Phys. Rev. Lett., 86, pp. 3200-3203. , Apr; Ang, K.C., A simple stocchastic model for an eepidemic-numerical eperiments with MATLAB (2007) Electron. J. Math. Technol., 1 (2), pp. 117-128; (2003) WHO the Cumulative Number of Reported Probable Cases of Severe Acute Respiratory Syndrome (SARS), , https://www.who.int/csr/sarscountry/2003-05-06/en, World Health Organization. May 6. Geneva, Swiss [Online]; Wu, J.T., Leung, K., Leung, G.M., Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: A modelling study (2020) Lancet, 395, pp. 689-697. , 10225, Feb./Mar; Li, Q., Guan, X.H., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia New England J. Med, , to be published; Huang, N.E., Qiao, F., A data driven time-dependent transmission rate for tracking an epidemic: A case study of 2019-nCoV Sci. Bull, , to be published","Zhong, L.; Key Laboratory of Regional Climate-Environment for Temperate East Asia, Institute of Atmospheric Physics, Chinese Academy of SciencesChina; email: zlh@mail.iap.ac.cn",,Institute of Electrical and Electronics Engineers Inc.,21693536,,,,English,IEEE Access,Article,Final,Open Access,Scopus,2-s2.0-85082508269,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Gong B., Zhang S., Yuan L., Chen K.Z.",57215932991;57215935269;57215933540;56957400300;,A balance act: minimizing economic loss while controlling novel coronavirus pneumonia,2020,Journal of Chinese Governance,,,,,,,,10.1080/23812346.2020.1741940,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082404811&doi=10.1080%2f23812346.2020.1741940&partnerID=40&md5=8bc9e10bd72eb0c700f02496b5238465,"China Academy for Rural Development and School of Public Affairs, Zhejiang University, Hangzhou, China; East and Central Asia Office, International Food Policy Research Institute, Beijing, China","Gong, B., China Academy for Rural Development and School of Public Affairs, Zhejiang University, Hangzhou, China; Zhang, S., China Academy for Rural Development and School of Public Affairs, Zhejiang University, Hangzhou, China; Yuan, L., China Academy for Rural Development and School of Public Affairs, Zhejiang University, Hangzhou, China; Chen, K.Z., China Academy for Rural Development and School of Public Affairs, Zhejiang University, Hangzhou, China, East and Central Asia Office, International Food Policy Research Institute, Beijing, China","The outbreak of Novel Coronavirus Pneumonia (NCP) has significantly affected China and beyond. How to effectively control such epidemic has gradually become a global issue. This paper reviews the economic impact of major epidemics such as SARS, H1N1, and Ebola at the micro-, sector-, and macro-level. The challenge of effective epidemic control is to achieve a balance between viral transmission reduction and economic cost. This paper then summarizes three main methods to evaluate the effectiveness of several control policies. We also find that the adequacy and authenticity of information disclosure is of great importance to minimize economic loss, as either public panic due to overestimation or lack of public awareness due to underestimation can cause additional negative economic impacts. Accurate and transparent disclosure of information plays a crucial role associated with fighting against the epidemic. Finally, the paper puts forward a number of policy recommendations to minimize economic loss while controlling the spread of COVID-19. © 2020, © 2020 Zhejiang University.",control measures; Economic impact of epidemics; information disclosure; Novel Coronavirus Pneumonia; public health events,,"Adda, J., Economic Activity and the Spread of Viral Diseases: Evidence from High Frequency Data (2016) The Quarterly Journal of Economics, 131 (2), pp. 891-941; Almond, D., Is the 1918 Influenza Pandemic over? 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Leung, et al; Sands, P., Mundaca-Shah, C., Dzau, V.J., The Neglected Dimension of Global Security — a Framework for Countering Infectious-Disease Crises (2016) New England Journal of Medicine, 374 (13), pp. 1281-1287; Siu, A., Wong, Y.C.R., Economic Impact of SARS: The Case of Hong Kong (2004) Asian Economic Papers, 3 (1), pp. 62-83; Tan, Z., Wu, S., Han, X., References and Enlightenments from the Public Health Emergency Response Systems of the United States of America and Japan—Pneumonia Epidemic Response to Novel Coronavirus Pneumonia in China (2020) Health Economics Research, pp. 1-6. , forthcoming (. :,.(in Chinese; Thomas, M.R., Smith, G., Ferreira, F.H.G., Evans, D., Maliszewska, M., Cruz, M., Himelein, K., (2015) The Economic Impact of Ebola on Sub-Saharan Africa: Updated Estimates for 2015, , Washington, DC: World Bank Group; Mass Media and the Contagion of Fear: The Case of Ebola in America (2015) PLoS ONE, 10 (6). , Towers, Sherry, Shehzad Afzal, Gilbert Bernal, Nadya Bliss, Shala Brown, Baltazar Espinoza, Jasmine Jackson, et al; The Three Horsemen of Riches: Plague, War, and Urbanization in Early Modern Europe (2012) The Review of Economic Studies, 80 (2), pp. 774-811. , Voigtländer, Nico, and Hans-Joachim Voth; Wang, C., Horby, P.W., Hayden, F.G., Gao, G.F., A Novel Coronavirus Outbreak of Global Health Concern (2020) The Lancet, 395 (10223), pp. 470-473; (2014) The Economic Impact of the 2014 Ebola Epidemic: Short—and Medium-Term Estimates for West Africa., , Washington, DC: World Bank Group; (2014) Update on the Economic Impact of the 2014–2015 Ebola Epidemic on Liberia, Sierra Leone, and Guinea., , Washington, DC: World Bank Group; (2015) The Economic Impact of Ebola on Sub-Saharan Africa: Updated Estimates for 2015, , Washington, DC: World Bank Group; (2009) Pandemic Influenza Preparedness and Response: A WHO Guidance Document, , Geneva: World Health Organization; (2005) WHO Checklist for Influenza Pandemic Preparedness Planning, , Geneva: World Health Organization; Yoo, B.-K., Kasajima, M., Bhattacharya, J., (2010) Public Avoidance and the Epidemiology of Novel H1N1 Influenza A., , National Bureau of Economic Research, and, Cambridge","Chen, K.Z.; China Academy for Rural Development, Zhejiang University, Room 1322, Qizhen Building, 866 Yuhangtang Road, China; email: kzchen@zju.edu.cn",,Taylor and Francis Ltd.,23812346,,,,English,J. Chinese Gov.,Article,Article in Press,Open Access,Scopus,2-s2.0-85082404811,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Ying T., Wang K., Liu X., Wen J., Goh E.",14625830600;57215903360;57194625725;57196723257;26534181500;,Rethinking game consumption in tourism: a case of the 2019 novel coronavirus pneumonia outbreak in China,2020,Tourism Recreation Research,,,,,,,1,10.1080/02508281.2020.1743048,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082312996&doi=10.1080%2f02508281.2020.1743048&partnerID=40&md5=a2f00fbd4ff3913b3af451d06be7b2ea,"Department of Tourism and Hotel Management, School of Management, Zhejiang University, Hangzhou, China; College of Tourism, Sichuan University, Chengdu, China; School of Business and Law, Edith Cowan University, Joondalup, Australia","Ying, T., Department of Tourism and Hotel Management, School of Management, Zhejiang University, Hangzhou, China; Wang, K., Department of Tourism and Hotel Management, School of Management, Zhejiang University, Hangzhou, China; Liu, X., College of Tourism, Sichuan University, Chengdu, China; Wen, J., School of Business and Law, Edith Cowan University, Joondalup, Australia; Goh, E., School of Business and Law, Edith Cowan University, Joondalup, Australia","This opinion piece highlights a lethal connection between novel coronavirus pneumonia (NCP) and wildlife consumption in tourism. While NCP continues to make headlines in the mainstream media, little academic research has considered this illness, especially through the lens of food neophilic tourism. Yet this research stream requires attention, particularly because food is a key motivational factor behind tourists’ travel and destination choices. In the case of food neophilic tourism, visitors directly consume wildlife and other exotic cuisine. Unfortunately, this novelty-seeking behavior may pose health risks; wild and exotic animals can carry deadly viruses that have been found to trigger global health epidemics such as SARS, H1N1, bird flu, and NCP. Despite international government agencies’ legislative efforts to control wild and exotic animal consumption, demand from food neophilic tourists continues to increase. This paper initiates a dialogue urging tourism scholars to study food tourism and offers practical and theoretical insight to contextualize this perennial and pertinent phenomenon. © 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group.",food neophilic tourists; food tourism; Novel coronavirus pneumonia; wild and exotic animal consumption,,"(2020), https://www.abc.net.au/news/2020-01-31/who-coronavirus-global-emergency/11916276, Coronavirus is a public health emergency, World Health Organization declares; Ahl, A.S., Nganwa, D., Wilson, S., Public health considerations in human consumption of wild game (2002) Annals of the New York Academy of Sciences, 969 (1), pp. 48-50. , https://doi.org/10.1111/j.1749-6632.2002.tb04349.x; Bertella, G., Ethical content of pictures of animals in tourism promotion (2013) Tourism Recreation Research, 38 (3), pp. 281-294. , https://doi.org/10.1080/02508281.2013.11081754; Biscayart, C., Angeleri, P., Lloveras, S., Chaves, T.D.S.S., Schlagenhauf, P., Rodríguez-Morales, A.J., The next big threat to global health? 2019 novel coronavirus (2019-nCoV): What advice can we give to travellers?-Interim recommendations January 2020, from the Latin-American society for Travel Medicine (SLAMVI) (2020) Travel Medicine and Infectious Disease, p. 33. , https://doi.org/10.1016/j.tmaid.2020.101567; Brotherton, B., Himmetoğlu, B., Beyond destinations—Special interest tourism (1997) Anatolia, 8 (3), pp. 11-30. , https://doi.org/10.1080/13032917.1997.9687118; Burger, J., Recreation, consumption of wild game, risk, and the Department of Energy sites: Perceptions of people attending the Lewiston, ID, “roundup” (1999) Journal of Toxicology and Environmental Health, Part A, 56 (4), pp. 221-234. , https://doi.org/10.1080/009841099158079; Coburn, H.L., Snary, E.L., Kelly, L.A., Wooldridge, M., Qualitative risk assessment of the hazards and risks from wild game (2005) Veterinary Record, 157 (11), pp. 321-322. , https://doi.org/10.1136/vr.157.11.321; Dai, J., (2008) The influence of farmhouse tourism on wildlife in Lin’an city, , http://www.wanfangdata.com.cn/details/detail.do?_type=degree%26id=Y1377611, [Master’s thesis]. 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A theoretical perspective (2019) Tourism Review International, 23 (1-2), pp. 71-77. , https://doi.org/10.3727/154427219X15561098338303; Yudina, O., Fennell, D., Ecofeminism in the tourism context: A discussion of the use of other-than-human animals as food in tourism (2013) Tourism Recreation Research, 38 (1), pp. 55-69. , https://doi.org/10.1080/02508281.2013.11081729; Zahler, P., Lhagvasuren, B., Reading, R.P., Wingard, J.R., Amgalanbaatar, S., Gombobaatar, S., Onon, Y., Illegal and unsustainable wildlife hunting and trade in Mongolia (2004) Mongolian Journal of Biological Sciences, 2 (2), pp. 23-31. , https://doi.org/10.22353/mjbs.2004.02.14, …; Zheng, F., Sun, J., Analysis on the causes of feeding wildlife in some areas of China (2005) Consumer Economy, 21 (5), pp. 82-86; Zhou, P., Yang, X.L., Wang, X.G., Hu, B., Zhang, L., Zhang, W., Si, H.-R., Chen, H.D., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature, pp. 1-4. , https://doi.org/10.1038/s41586-020-2012-7, …","Liu, X.; College of Tourism, Sichuan University, Wangjiang Road, China; email: liuxinyiscu@126.com",,Taylor and Francis Ltd.,2508281,,,,English,Tour. Recreat. Res.,Article,Article in Press,Open Access,Scopus,2-s2.0-85082312996,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Nicora C.D., Sims A.C., Bloodsworth K.J., Kim Y.-M., Moore R.J., Kyle J.E., Nakayasu E.S., Metz T.O.",13410209800;7102763252;56509466900;35201394400;35356015400;56810722800;8407996400;7004139728;,"Metabolite, protein, and lipid extraction (MPLEx): A method that simultaneously inactivates middle east respiratory syndrome coronavirus and allows analysis of multiple host cell components following infection",2020,Methods in Molecular Biology,2099,,,173,194,,,10.1007/978-1-0716-0211-9_14,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077313133&doi=10.1007%2f978-1-0716-0211-9_14&partnerID=40&md5=d285372af5863fcd5a77c21fbfd1c72b,"Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, United States; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States","Nicora, C.D., Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, United States; Sims, A.C., Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Bloodsworth, K.J., Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, United States; Kim, Y.-M., Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, United States; Moore, R.J., Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, United States; Kyle, J.E., Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, United States; Nakayasu, E.S., Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, United States; Metz, T.O., Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, United States","Mass spectrometry (MS)-based, integrated proteomics, metabolomics, and lipidomics (collectively, multi-omics) studies provide a very detailed snapshot of virus-induced changes to the host following infection and can lead to the identification of novel prophylactic and therapeutic targets for preventing or lessening disease severity. Multi-omics studies with Middle East respiratory syndrome coronavirus (MERS-CoV) are challenging as the requirements of biosafety level 3 containment limit the numbers of samples that can be safely managed. To address these issues, the multi-omics sample preparation technique MPLEx (metabolite, protein, and lipid extraction) was developed to partition a single sample into three distinct parts (metabolites, proteins, and lipids) for multi-omics analysis, while simultaneously inactivating MERS-CoV by solubilizing and disrupting the viral envelope and denaturing viral proteins. Here we describe the MPLEx protocol, highlight the step of inactivation, and describe the details of downstream processing, instrumental analysis of the three separate analytes, and their subsequent informatics pipelines. © Springer Science+Business Media, LLC, part of Springer Nature 2020.",Lipidomics; Mass spectrometry (MS); MERS-CoV; Metabolomics; MPLEx; Proteomics; Virus inactivation; Virus-host interactions,,"Modjarrad, K., A roadmap for MERS-CoV research and product development: Report from a World Health Organization consultation (2016) Nat Med, 22 (7), pp. 701-705; Aderem, A., A systems biology approach to infectious disease research: Innovating the pathogen-host research paradigm (2011) Mbio, 2 (1), p. e00325; Cockrell, A.S., A mouse model for MERS coronavirus-induced acute respiratory distress syndrome (2016) Nat Microbiol, 2, p. 16226; Menachery, V.D., MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape (2018) Proc Natl Acad Sci U S A, 115 (5), pp. E1012-E1021; Nakayasu, E.S., MPLEx: A Robust and universal protocol for single-sample integrative proteomic, metabolomic, and lipidomic analyses (2016) Msystems, 1 (3); Burnum-Johnson, K.E., MPLEx: A method for simultaneous pathogen inactiva-tion and extraction of samples for multi-omics profiling (2017) Analyst, 142 (3), pp. 442-448; Menachery, V.D., Pathogenic influenza viruses and coronaviruses utilize similar and contrasting approaches to control interferon-stimulated gene responses (2014) Mbio, 5 (3), p. e01174; Mitchell, H.D., A network integration approach to predict conserved regulators related to pathogenicity of influenza and SARS-CoV respiratory viruses (2013) Plos One, 8 (7); Gralinski, L.E., Mechanisms of severe acute respiratory syndrome coronavirus-induced acute lung injury (2013) Mbio, 4 (4); Sims, A.C., Release of severe acute respiratory syndrome coronavirus nuclear import block enhances host transcription in human lung cells (2013) J Virol, 87 (7), pp. 3885-3902; Kyle, J.E., Plasma lipidome reveals critical illness and recovery from human Ebola virus disease (2019) Proc Natl Acad Sci U S A, 116 (9), pp. 3919-3928; Eisfeld, A.J., Multi-platform omics analysis of human ebola virus disease pathogenesis (2017) Cell Host Microbe, 22 (6), pp. 817-829; Tisoncik-Go, J., Integrated omics analysis of pathogenic host responses during pandemic H1N1 influenza virus infection: The crucial role of lipid metabolism (2016) Cell Host Microbe, 19 (2), pp. 254-266; Nicod, C., Banaei-Esfahani, A., Collins, B.C., Elucidation of host-pathogen protein-protein interactions to uncover mechanisms of host cell rewiring (2017) Curr Opin Microbiol, 39, pp. 7-15; Wang, Y.P., Lei, Q.Y., Metabolite sensing and signaling in cell metabolism (2018) Signal Trans-Duct Target Ther, 3, p. 30; Deberardinis, R.J., Thompson, C.B., Cellular metabolism and disease: What do metabolic outliers teach us? (2012) Cell, 148 (6), pp. 1132-1144; Sanchez, E.L., Lagunoff, M., Viral activation of cellular metabolism (2015) Virology, 479, pp. 609-618; Wenk, M.R., Lipidomics of host-pathogen interactions (2006) Chem Phys Lipids, 143 (1-2), pp. 42-42; Knoops, K., SARS-coronavirus replication is supported by a reticulovesicular network of modified endoplasmic reticulum (2008) Plos Biol, 6 (9), pp. 1957-1974; Knoops, K., Integrity of the early secretory pathway promotes, but is not required for, severe acute respiratory syndrome coronavirus RNA synthesis and virus-induced remodeling of endoplasmic reticulum membranes (2010) J Virol, 84 (2), pp. 833-846; Ulasli, M., Qualitative and quantitative ultrastructural analysis of the membrane rearrangements induced by coronavirus (2010) Cell Microbiol, 12 (6), pp. 844-861; de Wilde, A.H., MERS-coronavirus replication induces severe in vitro cytopathol-ogy and is strongly inhibited by cyclosporin A or interferon-alpha treatment (2013) J Gen Virol, 94, pp. 1749-1760; Miller, S., Krijnse-Locker, J., Modification of intracellular membrane structures for virus replication (2008) Nat Rev Microbiol, 6 (5), pp. 363-374; Stapleford, K.A., Miller, D.J., Role of cellular lipids in positive-sense RNA virus replication complex assembly and function (2010) Viruses, 2 (5), pp. 1055-1068; Blanchard, E., Roingeard, P., Virus-induced double-membrane vesicles (2015) Cell Microbiol, 17 (1), pp. 45-50; Folch, J., Lees, M., Stanley, G.H.S., A simple method for the isolation and purification of total lipides from animal tissues (1957) J Biol Chem, 226 (1), pp. 497-509; Kind, T., FiehnLib: Mass spectral and retention index libraries for metabolomics based on quadrupole and time-of-flight gas chromatography/mass spectrometry (2009) Anal Chem, 81 (24), pp. 10038-10048; Adusumilli, R., Mallick, P., Data conversion with ProteoWizard msConvert (2017) Methods Mol Biol, 1550, pp. 339-368; Gibbons, B.C., Correcting systematic bias and instrument measurement drift with mzRefinery (2015) Bioinformatics, 31 (23), pp. 3838-3840; Kim, S., Pevzner, P.A., MS-GF+ makes progress towards a universal database search tool for proteomics (2014) Nat Commun, 5; Monroe, M.E., MASIC: A software program for fast quantitation and flexible visualization of chromatographic profiles from detected LC-MS(/MS) features (2008) Comput Biol Chem, 32 (3), pp. 215-217; Hiller, K., MetaboliteDetector: Comprehensive analysis tool for targeted and non-targeted GC/MS based metabolome analysis (2009) Anal Chem, 81 (9), pp. 3429-3439; Kyle, J.E., LIQUID: An-open source software for identifying lipids in LC-MS/MS-based lipidomics data (2017) Bioinformatics, 33 (11), pp. 1744-1746; Pluskal, T., MZmine 2: Modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data (2010) BMC Bioinformatics, 11; Wang, Y., Reversed-phase chromatography with multiple fraction concatenation strategy for proteome profiling of human MCF10A cells (2011) Proteomics, 11 (10), pp. 2019-2026","Metz, T.O.; Biological Sciences Division, Pacific Northwest National LaboratoryUnited States; email: Thomas.metz@pnnl.gov",,Humana Press Inc.,10643745,,,31883096,English,Methods Mol. Biol.,Book Chapter,Final,Open Access,Scopus,2-s2.0-85077313133,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Ding Q., Lu P., Fan Y., Xia Y., Liu M.",7102341288;57189520637;57191253542;57216038469;56538998800;,"The clinical characteristics of pneumonia patients coinfected with 2019 novel coronavirus and influenza virus in Wuhan, China",2020,Journal of Medical Virology,,,,,,,,10.1002/jmv.25781,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082522652&doi=10.1002%2fjmv.25781&partnerID=40&md5=88b88c412cbfe329eb890b70cc0b9bcd,"Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Department of Gastroenterology, Internal Medicine II, Klinikum rechts der Isar, Technical University of Munich (TUM), Munich, Germany","Ding, Q., Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Lu, P., Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Fan, Y., Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, Department of Gastroenterology, Internal Medicine II, Klinikum rechts der Isar, Technical University of Munich (TUM), Munich, Germany; Xia, Y., Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Liu, M., Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China","The outbreak of 2019 novel coronavirus (COVID-19) infection emerged in Wuhan, China, in December 2019. Since then the novel coronavirus pneumonia disease has been spreading quickly and many countries and territories have been affected, with major outbreaks in China, South Korea, Italy, and Iran. Influenza virus has been known as a common pathogen in winter and it can cause pneumonia. It was found clinically that very few patients were diagnosed with both COVID-19 and influenza virus. A total of 5 of the 115 patients confirmed with COVID-19 were also diagnosed with influenza virus infection, with three cases being influenza A and two cases being influenza B. In this study, we describe the clinical characteristics of those patients who got infected with COVID-19 as well as influenza virus. Common symptoms at onset of illness included fever (five [100%] patients), cough (five [100%] patients), shortness of breath (five [100%] patients), nasal tampon (three [60%] patients), pharyngalgia (three [60%] patients), myalgia (two [40%] patients), fatigue (two [40%] patients), headache (two [40%] patients), and expectoration (two [40%] patients). The laboratory results showed that compared to the normal values, the patients' lymphocytes were reduced (four [80%] patients), and liver functions alanine aminotransferase and aspartate aminotransferase (two [40%] patients and two [40%] patients) and C-reactive protein (four [80%] patients) were increased when admitted to hospital. They stayed in the hospital for 14, 30, 17, 12, and 19 days (28.4 ± 7.02), respectively. The main complications for the patients were acute respiratory distress syndrome (one [20%] patients), acute liver injury (three [60%] patients), and diarrhea (two [40%] patients). All patients were given antiviral therapy (including oseltamivir), oxygen inhalation, and antibiotics. Three patients were treated with glucocorticoids including two treated with oral glucocorticoids. One of the five patients had transient hemostatic medication for hemoptysis. Fortunately, all patients did not need intensive care unit and were discharged from the hospital without death. In conclusion, those patients with both COVID-19 and influenza virus infection did not appear to show a more severe condition because based on the laboratory findings, imaging studies, and patient prognosis, they showed similar clinical characteristics as those patients with COVID-19 infection only. However, it is worth noting that the symptoms of nasal tampon and pharyngalgia may be more prone to appear for those coinfection patients. © 2020 Wiley Periodicals, Inc.",clinical characteristics; coinfection; COVID-19; influenza virus,,"Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382 (8), pp. 727-733; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395 (10223), pp. 497-506; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395 (10223), pp. 507-513; Wang, D., Hu, B., Hu, C., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) JAMA, 323, pp. 1061-1069; Guan, W., Ni, Z., Hu, Y., Clinical characteristics of coronavirus disease 2019 in China N Engl J Med, , https://doi.org/10.1056/NEJMoa2002032, [published online ahead of print February 28, 2020]; Ai, T., Yang, Z., Hou, H., Correlation of chest CT and RT-PCR testing in coronavirus disease 2019 (COVID-19) in China: a report of 1014 cases Radiology, , https://doi.org/10.1148/radiol.2020200642, [published online ahead of print February 26 2020]; Chung, M., Bernheim, A., Mei, X., CT imaging features of 2019 novel coronavirus (2019-nCoV) (2020) Radiology, 295, pp. 202-207; Riou, J., Althaus, C.L., Pattern of early human-to-human transmission of Wuhan 2019 novel coronavirus (2019-nCoV), December 2019 to January 2020 (2020) Euro Surveill, 25 (4); Zhang, N., Wang, L., Deng, X., Recent advances in the detection of respiratory virus infection in humans (2020) J Med Virol, 92 (4), pp. 408-417; Caini, S., Kroneman, M., Wiegers, T., El Guerche-Seblain, C., Paget, J., Clinical characteristics and severity of influenza infections by virus type, subtype, and lineage: a systematic literature review (2018) Influenza Other Respir Viruses, 12 (6), pp. 780-792; Schoen, K., Horvat, N., Guerreiro, N.F.C., de Castro, I., de Giassi, K.S., Spectrum of clinical and radiographic findings in patients with diagnosis of H1N1 and correlation with clinical severity (2019) BMC Infect Dis, 19 (1), p. 964; Keske, S., Gumus, T., Koymen, T., Sandikci, S., Tabak, L., Ergonul, O., Human metapneumovirus infection: diagnostic impact of radiologic imaging (2019) J Med Virol, 91 (6), pp. 958-962; Notice on the issuance of a program for the diagnosis and treatment of novel coronavirus (2019-nCoV) infected pneumonia (fourth trial version to sixth trial version), , http://www.nhc.gov.cn/yzygj/pqt/new_list.shtml; Zhang, H., Kang, Z., Gong, H., The digestive system is a potential route of 2019-nCov infection: a bioinformatics analysis based on single-cell transcriptomes bioRxiv, , https://doi.org/10.1101/2020.01.30.927806, [published online ahead of print January 31, 2020]; de Wit, E., van Doremalen, N., Falzarano, D., Munster, V.J., SARS and MERS: recent insights into emerging coronaviruses (2016) Nat Rev Microbiol, 14 (8), pp. 523-534","Liu, M.; Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyChina; email: fliumei@126.com",,John Wiley and Sons Inc.,1466615,,JMVID,32196707,English,J. Med. Virol.,Article,Article in Press,Open Access,Scopus,2-s2.0-85082522652,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Ki M., Task Force for 2019-nCoV",57216009651;,Epidemiologic characteristics of early cases with 2019 novel coronavirus (2019-nCoV) disease in Korea,2020,Epidemiology and health,42,,,e2020007,,,,10.4178/epih.e2020007,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082097737&doi=10.4178%2fepih.e2020007&partnerID=40&md5=19f04c7a928430b83a469b7e91a72a63,"Department of Cancer Control and Population Health, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, South Korea","Ki, M., Department of Cancer Control and Population Health, Graduate School of Cancer Science and Policy, National Cancer Center, Goyang, South Korea; Task Force for 2019-nCoV","In about 20 days since the diagnosis of the first case of the 2019 novel coronavirus (2019-nCoV) in Korea on January 20, 2020, 28 cases have been confirmed. Fifteen patients (53.6%) of them were male and median age of was 42 years (range, 20-73). Of the confirmed cases, 16, 9, and 3 were index (57.2%), first-generation (32.1%), and second-generation (10.7%) cases, respectively. All first-generation and second-generation patients were family members or intimate acquaintances of the index cases with close contacts. Fifteen among 16 index patients had entered Korea from January 19 to 24, 2020 while 1 patient had entered Korea on January 31, 2020. The average incubation period was 3.9 days (median, 3.0), and the reproduction number was estimated as 0.48. Three of the confirmed patients were asymptomatic when they were diagnosed. Epidemiological indicators will be revised with the availability of additional data in the future. Sharing epidemiological information among researchers worldwide is essential for efficient preparation and response in tackling this new infectious disease.",2019-nCoV; Epidemiology; Isolation; Korea; Outbreak; Quarantine,"COVID-19; severe acute respiratory syndrome coronavirus 2; adult; aged; asymptomatic disease; Betacoronavirus; contact examination; Coronavirus infection; family health; female; human; incubation time; isolation and purification; male; middle aged; pathogenicity; South Korea; virus pneumonia; young adult; Adult; Aged; Asymptomatic Diseases; Betacoronavirus; Contact Tracing; Coronavirus Infections; Family Health; Female; Humans; Infectious Disease Incubation Period; Male; Middle Aged; Pneumonia, Viral; Republic of Korea; Young Adult",,,,NLM (Medline),20927193,,,32035431,English,Epidemiol Health,Article,Final,Open Access,Scopus,2-s2.0-85082097737,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Calvo C., García López-Hortelano M., de Carlos Vicente J.C., Vázquez Martínez J.L., Ramos J.T., Baquero-Artigao F., Navarro M.L., Rodrigo C., Neth O., Fumadó V., Menendez Suso J.J., Slocker Barrio M., Bustinza Arriortua A., Jordán García I., Pilar Orive J., Grupo de trabajo de la Asociacion Espanola de Pediatria para el brote de infeccion por Coronavirus, colaboradores con el Ministerio de Sanidad, Miembros del Grupo de Expertos de la AEP",57202226571;53864883400;6505875274;6602149601;57211720075;6602828942;7201561673;57190123556;6506737455;21933723700;8448213200;56392999600;6505988243;57197869321;57205679203;,Recommendations on the clinical management of the COVID-19 infection by the «new coronavirus» SARS-CoV2. Spanish Paediatric Association working group [Recomendaciones sobre el manejo clínico de la infección por el «nuevo coronavirus» SARS-CoV2. Grupo de trabajo de la Asociación Española de Pediatría (AEP)],2020,Anales de Pediatria,,,,,,,1,10.1016/j.anpedi.2020.02.001,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081904142&doi=10.1016%2fj.anpedi.2020.02.001&partnerID=40&md5=82a1ac6c0bac6f421cc279301749835c,"Sociedad Española de Infectología Pediátrica (SEIP); Servicio de Pediatría, Enfermedades Infecciosas y Tropicales, Hospital Universitario La Paz, Madrid, Spain; Unidad de Aislamiento de Alto Nivel (UAAN), Hospital La Paz-Carlos III, Madrid, Spain; Sociedad Española de Cuidados Intensivos Pediátricos (SECIP); Unidad de Cuidados Intensivos Pediátricos, Hospital Son Espases, Palma de Mallorca, Spain; Unidad de Cuidados Intensivos Pediátricos, Hospital Ramón y Cajal, Madrid, Spain; Unidad de Enfermedades Infecciosas, Servicio de Pediatría, Hospital Clínico San Carlos, Departamento de Salud Pública y Materno-Infantil, Madrid, Spain; Servicio de Pediatría y Enfermedades Infecciosas, Hospital Universitario Gregorio Marañón, Madrid, Spain; Dirección Clínica de Pediatría, Hospital Universitario Germans Trias i Pujol, Badalona, Barcelona, Spain; Sección de Enfermedades Infecciosas, Reumatología e Inmunodeficiencias, Hospital Infantil Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS), Sevilla, Spain; Unitat de Malalties Infeccioses i Importades (CSUR). Unidad de Alto Aislamiento de Enfermedades Infecciosas (CSUR), Hospital Universitario Sant Joan de Déu, Barcelona, Spain; Servicio de Cuidados Intensivos y de la Unidad de Aislamiento de Alto Nivel (UAAN), Hospital Universitario La Paz-Carlos III, Madrid, Spain; Unidad de Cuidados Intensivos Pediátricos, Hospital Materno Infantil Gregorio Marañón, Madrid, Spain; Unidad de Cuidados Intensivos Pediátricos, Hospital Sant Joan de Déu, Barcelona, Spain; Unidad de Cuidados Intensivos Pediátricos, Hospital Universitario de Cruces, Baracaldo, Bizkaia, Spain; Sociedad Española de Infectología Pediátrica; Sociedad Española de Cuidados Intensivos Pediátricos","Calvo, C., Sociedad Española de Infectología Pediátrica (SEIP), Servicio de Pediatría, Enfermedades Infecciosas y Tropicales, Hospital Universitario La Paz, Madrid, Spain; García López-Hortelano, M., Sociedad Española de Infectología Pediátrica (SEIP), Servicio de Pediatría, Enfermedades Infecciosas y Tropicales, Hospital Universitario La Paz, Madrid, Spain, Unidad de Aislamiento de Alto Nivel (UAAN), Hospital La Paz-Carlos III, Madrid, Spain; de Carlos Vicente, J.C., Sociedad Española de Cuidados Intensivos Pediátricos (SECIP), Unidad de Cuidados Intensivos Pediátricos, Hospital Son Espases, Palma de Mallorca, Spain; Vázquez Martínez, J.L., Sociedad Española de Cuidados Intensivos Pediátricos (SECIP), Unidad de Cuidados Intensivos Pediátricos, Hospital Ramón y Cajal, Madrid, Spain; Ramos, J.T., Unidad de Enfermedades Infecciosas, Servicio de Pediatría, Hospital Clínico San Carlos, Departamento de Salud Pública y Materno-Infantil, Madrid, Spain, Sociedad Española de Infectología Pediátrica; Baquero-Artigao, F., Servicio de Pediatría, Enfermedades Infecciosas y Tropicales, Hospital Universitario La Paz, Madrid, Spain, Unidad de Aislamiento de Alto Nivel (UAAN), Hospital La Paz-Carlos III, Madrid, Spain, Sociedad Española de Infectología Pediátrica; Navarro, M.L., Servicio de Pediatría y Enfermedades Infecciosas, Hospital Universitario Gregorio Marañón, Madrid, Spain, Sociedad Española de Infectología Pediátrica; Rodrigo, C., Dirección Clínica de Pediatría, Hospital Universitario Germans Trias i Pujol, Badalona, Barcelona, Spain, Sociedad Española de Infectología Pediátrica; Neth, O., Sección de Enfermedades Infecciosas, Reumatología e Inmunodeficiencias, Hospital Infantil Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS), Sevilla, Spain, Sociedad Española de Infectología Pediátrica; Fumadó, V., Unitat de Malalties Infeccioses i Importades (CSUR). Unidad de Alto Aislamiento de Enfermedades Infecciosas (CSUR), Hospital Universitario Sant Joan de Déu, Barcelona, Spain, Sociedad Española de Infectología Pediátrica; Menendez Suso, J.J., Servicio de Cuidados Intensivos y de la Unidad de Aislamiento de Alto Nivel (UAAN), Hospital Universitario La Paz-Carlos III, Madrid, Spain, Sociedad Española de Cuidados Intensivos Pediátricos; Slocker Barrio, M., Unidad de Cuidados Intensivos Pediátricos, Hospital Materno Infantil Gregorio Marañón, Madrid, Spain, Sociedad Española de Cuidados Intensivos Pediátricos; Bustinza Arriortua, A., Unidad de Cuidados Intensivos Pediátricos, Hospital Materno Infantil Gregorio Marañón, Madrid, Spain, Sociedad Española de Cuidados Intensivos Pediátricos; Jordán García, I., Unidad de Cuidados Intensivos Pediátricos, Hospital Sant Joan de Déu, Barcelona, Spain, Sociedad Española de Cuidados Intensivos Pediátricos; Pilar Orive, J., Unidad de Cuidados Intensivos Pediátricos, Hospital Universitario de Cruces, Baracaldo, Bizkaia, Spain, Sociedad Española de Cuidados Intensivos Pediátricos; Grupo de trabajo de la Asociacion Espanola de Pediatria para el brote de infeccion por Coronavirus, colaboradores con el Ministerio de Sanidad; Miembros del Grupo de Expertos de la AEP","On 31 December 2019, the Wuhan Municipal Committee of Health and Healthcare (Hubei Province, China) reported that there were 27 cases of pneumonia of unknown origin with symptoms starting on the 8 December. There were 7 serious cases with common exposure in market with shellfish, fish, and live animals, in the city of Wuhan. On 7 January 2020, the Chinese authorities identified that the agent causing the outbreak was a new type of virus of the Coronaviridae family, temporarily called «new coronavirus», 2019-nCoV. On January 30th, 2020, the World Health Organisation (WHO) declared the outbreak an International Emergency. On 11 February 2020 the WHO assigned it the name of SARS-CoV2 and COVID-19 (SARS-CoV2 and COVID-19). The Ministry of Health summoned the Specialties Societies to prepare a clinical protocol for the management of COVID-19. The Spanish Paediatric Association appointed a Working Group of the Societies of Paediatric Infectious Diseases and Paediatric Intensive Care to prepare the present recommendations with the evidence available at the time of preparing them. © 2020 Asociación Española de Pediatría",2019-nCoV; Children; Coronavirus; COVID-19; Respiratory infection; SARS-CoV2,,"https://www.mscbs.gob.es/profesionales/saludPublica/ccayes/alertasActual/nCov-China/documentos/Procedimiento_2019-nCoV.pdf, Centro de Coordinación de Alertas y Emergencias Sanitarias. Dirección General de Salud Pública. Ministerio de Sanidad. Instituto de Salud Carlos III. Procedimiento de actuación frente a casos de infección por el nuevo coronavirus (2019-nCoV) [actualizado 6 Feb 2020]. Disponible en:; (2005), https://www.who.int/news-room/detail/30-01-2020-statement-on-the-second-meeting-of-the-international-health-regulations–emergency-committee-regarding-the-outbreak-of-novel-coronavirus-(2019-ncov), WHO. Statement on the second meeting of the International Health Regulations Emergency Committee regarding the outbreak of novel coronavirus (2019-nCoV). 30 January 2020. Disponible en:; Cai, J.H., Wang, X.S., Ge, Y.L., Xia, A.M., Chang, H.L., Tian, H., First case of 2019 novel coronavirus infection in children in Shanghai (2020) Zhonghua Er Ke Za Zhi., 58, p. E002; Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tonget, Y., Early transmission dynamics in Wuhan China, of novel coronavirus-infected pneumonia (2020) N Engl J Med.; Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet., 395, pp. 507-513; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet., 395, pp. 497-506; WHO. 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Home care for patients with suspected novel coronavirus (nCoV) infection presenting with mild symptoms and management of contacts. WHO/nCov/IPC_HomeCare/2020.1; Khemani, R.G., Smith, L.S., Zimmerman, J.J., Erickson, S., Pediatric acute respiratory distress syndrome: definition, incidence, and epidemiology: proceedings from the Pediatric Acute Lung Injury Consensus Conference (2015) Pediatr Crit Care Med, 16, pp. S23-S40; Rimensberger, P.C., Cheifetz, I.M., Ventilatory support in children with pediatric acute respiratory distress syndrome: proceedings from the Pediatric Acute Lung Injury Consensus Conference (2015) Pediatr Crit Care Med., 16, pp. S51-S60; Fan, E., del Sorbo, L., Goligher, E.C., Hodgson, C.L., Munshi, L., Walkeyet, A.J., An Official American Thoracic Society/European Society of Intensive Care Medicine/Society of Critical Care Medicine Clinical Practice Guideline: Mechanical ventilation in adult patients with acute respiratory distress syndrome (2017) Am J Respir Crit Care Med., 195, pp. 1253-1263; Rhodes, A., Evans, L.E., Alhazzani, W., Levy, M.M., Antonelli, M., Ferrer, R., Surviving Sepsis Campaign: International guidelines for management of sepsis and septic shock: 2016 (2017) Intensive Care Med., 43, pp. 304-377; Weiss, S.L., Peters, M.J., Alhazzani, W., Agus, M.S.D., Flori, H.R., Inwald, D.P., Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children (2020) Crit Care Med., 21, pp. e52-e106; Rodrigo, C., Leonardi-Bee, J., Nguyen-Van-Tam, J., Lim, W.S., Corticosteroids as adjunctive therapy in the treatment of influenza (2016) Cochrane Database Syst Rev., 3, p. CD010406; Delaney, J.W., Pinto, R., Long, J., Lamontagne, F., Adhikari, N.K., Kumar, A., The influence of corticosteroid treatment on the outcome of influenza A(H1N1pdm09)-related critical illness (2016) Crit Care., 20, p. 75; Arabi, Y.M., Mandourah, Y., Al-Hameed, F., Sindi, A.A., Almekhlafi, G.A., Hussein, M.A., Corticosteroid therapy for critically ill patients with Middle East respiratory syndrome (2018) Am J Respir Crit Care Med., 197, pp. 757-767; Lu, H., Drug treatment options for the 2019-new coronavirus (2019-nCoV) (2020) BioScience Trends.; Chu, C.M., Cheng, V.C., Hung, I.F., Wong, M.M., Chan, K.H., Chan, K.S., Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings (2004) Thorax., 59, pp. 252-256; Sheahan, T.P., Sims, A.C., Leist, S.R., Schäfer, A., Won, J., Brownet, A.J., Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERSCoV (2020) Nat Commun., 11, p. 222; Agostini, M.L., Andres, E.L., Sims, A.C., Graham, R.L., Sheahan, T.P., Lu, X., Coronavirus susceptibility to the antiviral remdesivir (GS-5734) is mediated by the viral polymerase and the proofreading exoribonuclease (2018) mBio., 9. , pii: e00221-18; Holshue, M.L., DeBolt, C., Lindquist, S., Lofy, K.H., Wiesman, J., Bruce, H., First case of 2019 novel coronavirus in the United States (2020) N Engl J Med.; Wang, M., Cao, R., Zhang, L., Yang, X., Liu, J., Xuet, M., Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro (2020) Cell Res.; Richardson, P., Griffin, I., Tucker, C., Smith, D., Oechsle, O., Phelan, A., Baricitinib as potential treatment for 2019-nCoV acute respiratory disease (2020) Lancet., 395, pp. e30-e31","Calvo, C.; Sociedad Española de Infectología Pediátrica (SEIP)email: ccalvorey@gmail.com",,Elsevier Doyma,16954033,,APNEC,,English; Spanish,An. Pediatr.,Article,Article in Press,Open Access,Scopus,2-s2.0-85081904142,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Koonin L.M.,7003418541;,Novel coronavirus disease (COVID-19) outbreak: Now is the time to refresh pandemic plans,2020,Journal of business continuity & emergency planning,13,4,,1,15,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081897631&partnerID=40&md5=604b78d7536ceb21fcdb56d4bca2ecb8,Health Preparedness Partners,"Koonin, L.M., Health Preparedness Partners","This article outlines practical steps that businesses can take now to prepare for a pandemic. Given the current growing spread of coronavirus disease 2019 (COVID-19) around the world, it is imperative that businesses review their pandemic plans and be prepared in case this epidemic expands and affects more people and communities. Preparing for a potential infectious disease pandemic from influenza or a novel corona virus is an essential component of a business continuity plan, especially for businesses that provide critical healthcare and infrastructure services. Although many businesses and organisations have a pandemic plan or address pandemic preparedness in their business continuity plans, few have recently tested and updated their plans. Pandemics can not only interrupt an organisation's operations and compromise long-term viability of an enterprise, but also disrupt the provision of critical functions. Businesses that regularly test and update their pandemic plan can significantly reduce harmful impacts to the business, play a key role in protecting employees' and customers' health and safety, and limit the negative impact of a pandemic on the community and economy.",,"COVID-19; commercial phenomena; Coronavirinae; Coronavirus infection; disaster planning; epidemic; health care delivery; human; influenza; organization and management; pandemic; virus pneumonia; Commerce; Coronavirus; Coronavirus Infections; Delivery of Health Care; Disaster Planning; Disease Outbreaks; Humans; Influenza, Human; Pandemics; Pneumonia, Viral",,,,NLM (Medline),17499216,,,32160942,English,J Bus Contin Emer Plan,Article,Final,,Scopus,2-s2.0-85081897631,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wang Z., Chen X., Lu Y., Chen F., Zhang W.",57215853820;55521344400;57215853114;57215852610;57192224287;,Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined Chinese and Western medicine treatment,2020,BioScience Trends,14,1,1030,,,,7,10.5582/BST.2020.01030,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080854126&doi=10.5582%2fBST.2020.01030&partnerID=40&md5=af3f72ab63adec427ceb1cfd3fc1262d,"Department of Respiratory Disease, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Department of Traditional Chinese Medicine, Shanghai Public Health Clinical Center, Shanghai, China; Department of Respiratory Disease, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China","Wang, Z., Department of Respiratory Disease, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Chen, X., Department of Traditional Chinese Medicine, Shanghai Public Health Clinical Center, Shanghai, China; Lu, Y., Department of Traditional Chinese Medicine, Shanghai Public Health Clinical Center, Shanghai, China; Chen, F., Department of Respiratory Disease, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China; Zhang, W., Department of Respiratory Disease, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China","Pneumonia associated with the 2019 novel coronavirus (2019-nCoV) is continuously and rapidly circulating at present. No effective antiviral treatment has been verified thus far. We report here the clinical characteristics and therapeutic procedure for four patients with mild or severe 2019-nCoV pneumonia admitted to Shanghai Public Health Clinical Center. All the patients were given antiviral treatment including lopinavir/ritonavir (Kaletra®), arbidol, and Shufeng Jiedu Capsule (SFJDC, a traditional Chinese medicine) and other necessary support care. After treatment, three patients gained significant improvement in pneumonia associated symptoms, two of whom were confirmed 2019-nCoV negative and discharged, and one of whom was virus negative at the first test. The remaining patient with severe pneumonia had shown signs of improvement by the cutoff date for data collection. Results obtained in the current study may provide clues for treatment of 2019-nCoV pneumonia. The efficacy of antiviral treatment including lopinavir/ritonavir, arbidol, and SFJDC warrants further verification in future study. © 2020 International Advancement Center for Medicine and Health Research Co., Ltd.",2019-nCoV; Arbidol; Lopinavir; Ritonavir; Shufeng Jiedu Capsule,"antivirus agent; arbidol; COVID-19; herbaceous agent; indole derivative; lopinavir; lopinavir-ritonavir drug combination; ritonavir; severe acute respiratory syndrome coronavirus 2; shufeng jiedu; adult; Betacoronavirus; case report; China; Coronavirus infection; drug combination; female; human; male; middle aged; retrospective study; virus pneumonia; young adult; Adult; Antiviral Agents; Betacoronavirus; China; Coronavirus Infections; Drug Combinations; Drugs, Chinese Herbal; Female; Humans; Indoles; Lopinavir; Male; Middle Aged; Pneumonia, Viral; Retrospective Studies; Ritonavir; Young Adult","Gralinski, L.E., Menachery, V.D., Return of the Coronavirus: 2019-nCoV (2020) Viruses., 12; Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China (2019) N Engl J Med., (2020); National Health Commission of the People's Republic of China (2019), http://www.nhc.gov.cn/xcs/yqtb/202002/17a03704a99646ffad6807bc806f37a4.shtml, (accessed February 5, ). (in Chinese); (2020), http://www.nhc.gov.cn/yzygj/s7653p/202002/3b09b894ac9b4204a79db5b8912d4440.shtml, (accessed February 5; Lu, H., Drug treatment options for the 2019-new coronavirus (2019-nCoV) (2020) Biosci Trends.; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet.; Su, B., Wang, Y., Zhou, R., Jiang, T., Zhang, H., Li, Z., Liu, A., Sun, L., Efficacy and tolerability of lopinavir/ritonavir- and efavirenz-based initial antiretroviral therapy in HIV-1-infected patients in a tertiary care hospital in Beijing, China. (2019) Front Pharmacol., 10, p. 1472; Chu, C.M., Cheng, V.C., Hung, I.F., Wong, M.M., Chan, K.H., Chan, K.S., Kao, R.Y., Yuen, K.Y., Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings (2004) Thorax., 59, pp. 252-256; Wang, Y., Ding, Y., Yang, C., Li, R., Du, Q., Hao, Y., Li, Z., He, Z., Inhibition of the infectivity and inflammatory response of influenza virus by arbidol hydrochloride in vitro and in vivo (mice and ferret) (2017) Biomed Pharmacother., 91, pp. 393-401; (2020), http://www.sd.chinanews.com/2/2020/0205/70145.html, (accessed February 5). (in Chinese); (2019), http://www.chictr.org.cn/showproj.aspx?proj=49065, (accessed February 5","Zhang, W.; Department of Respiratory Disease, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineChina; email: zhangw1190@sina.com",,"International Advancement Center for Medicine and Health Research Co., Ltd.",18817815,,,32037389,English,BioScience Trends,Article,Final,Open Access,Scopus,2-s2.0-85080854126,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Ma-Lauer Y., Zheng Y., Malešević M., von Brunn B., Fischer G., von Brunn A.",55386900200;57215350116;23100280600;6504186925;57215346562;6701437402;,Influences of cyclosporin A and non-immunosuppressive derivatives on cellular cyclophilins and viral nucleocapsid protein during human coronavirus 229E replication,2020,Antiviral research,173,,,104620,,,,10.1016/j.antiviral.2019.104620,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85076503156&doi=10.1016%2fj.antiviral.2019.104620&partnerID=40&md5=a0005f4c834fa1253e821f0db2acc5ba,"Max von Pettenkofer-Institute, Ludwig-Maximilians-University, Munich, Germany; German Center for Infection Research (DZIF), Partner Site Munich, 80336, Munich, Germany; Institute of Biochemistry and Biotechnology, Martin-Luther-University Halle-Wittenberg, Halle, Germany; Max-Planck-Institute of Biophysical Chemistry Goettingen, Germany; Max von Pettenkofer-Institute, Ludwig-Maximilians-University, Munich, Germany; German Center for Infection Research (DZIF), Partner Site Munich, 80336, Munich, Germany. Electronic address: vonbrunn@mvp.lmu.de","Ma-Lauer, Y., Max von Pettenkofer-Institute, Ludwig-Maximilians-University, Munich, Germany; German Center for Infection Research (DZIF), Partner Site Munich, 80336, Munich, Germany; Zheng, Y., Max von Pettenkofer-Institute, Ludwig-Maximilians-University, Munich, Germany; German Center for Infection Research (DZIF), Partner Site Munich, 80336, Munich, Germany; Malešević, M., Institute of Biochemistry and Biotechnology, Martin-Luther-University Halle-Wittenberg, Halle, Germany; von Brunn, B., Max von Pettenkofer-Institute, Ludwig-Maximilians-University, Munich, Germany; German Center for Infection Research (DZIF), Partner Site Munich, 80336, Munich, Germany; Fischer, G., Max-Planck-Institute of Biophysical Chemistry Goettingen, Germany; von Brunn, A., Max von Pettenkofer-Institute, Ludwig-Maximilians-University, Munich, Germany; German Center for Infection Research (DZIF), Partner Site Munich, 80336, Munich, Germany. Electronic address: vonbrunn@mvp.lmu.de","The well-known immunosuppressive drug cyclosporin A inhibits replication of various viruses including coronaviruses by binding to cellular cyclophilins thus inactivating their cis-trans peptidyl-prolyl isomerase function. Viral nucleocapsid proteins are inevitable for genome encapsidation and replication. Here we demonstrate the interaction between the N protein of HCoV-229E and cyclophilin A, not cyclophilin B. Cyclophilin inhibitors abolish this interaction. Upon infection, cyclophilin A stays evenly distributed throughout the cell, whereas cyclophilin B concentrates at ER-bleb-like structures. We further show the inhibitory potential of non-immunosuppressive CsA derivatives Alisporivir, NIM811, compound 3 on HCoV-229E-GFP and -Luciferase replication in human Huh-7.5 hepatoma cells at 18 and 48 h time points post infection with EC50 s at low micromolar ranges. Thus, non-immunosuppressive CsA derivatives effectively inhibit HCoV-229E replication suggesting them as possible candidates for the treatment of HCoV infection. The interruption of interaction between CypA and N protein by CsA and its derivatives suggest a mechanism how CypA inhibitors suppress viral replication. Copyright © 2019. Published by Elsevier B.V.",Broad-spectrum antiviral; Coronavirus nucleocapsid; Cyclophilin A/B; Cyclophilin inhibitors; HCoV-229E,,,,,NLM (Medline),18729096,,,31634494,English,Antiviral Res.,Article,Final,Open Access,Scopus,2-s2.0-85076503156,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Inciardi R.M., Lupi L., Zaccone G., Italia L., Raffo M., Tomasoni D., Cani D.S., Cerini M., Farina D., Gavazzi E., Maroldi R., Adamo M., Ammirati E., Sinagra G., Lombardi C.M., Metra M.",56015777500;54910152200;57215970642;57200007221;57215963479;57214231971;57189727642;23968620900;7004908037;24463188200;7003402149;56113383300;25923325700;57215758305;56653133600;57214983124;,Cardiac Involvement in a Patient with Coronavirus Disease 2019 (COVID-19),2020,JAMA Cardiology,,,,,,,2,10.1001/jamacardio.2020.1096,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082499194&doi=10.1001%2fjamacardio.2020.1096&partnerID=40&md5=ae62f1a7e2cee2c4ef0ae24d8acc3167,"Institute of Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, C/o Spedali Civili, Piazzale Spedali Civili 1, Brescia BS, 25123, Italy; Institute of Radiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy; De Gasperis Cardio Center, Transplant Center, Niguarda Hospital, Milan, Italy; Cardiovascular Department, Ospedali Riuniti, University of Trieste, Trieste, Italy","Inciardi, R.M., Institute of Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, C/o Spedali Civili, Piazzale Spedali Civili 1, Brescia BS, 25123, Italy; Lupi, L., Institute of Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, C/o Spedali Civili, Piazzale Spedali Civili 1, Brescia BS, 25123, Italy; Zaccone, G., Institute of Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, C/o Spedali Civili, Piazzale Spedali Civili 1, Brescia BS, 25123, Italy; Italia, L., Institute of Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, C/o Spedali Civili, Piazzale Spedali Civili 1, Brescia BS, 25123, Italy; Raffo, M., Institute of Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, C/o Spedali Civili, Piazzale Spedali Civili 1, Brescia BS, 25123, Italy; Tomasoni, D., Institute of Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, C/o Spedali Civili, Piazzale Spedali Civili 1, Brescia BS, 25123, Italy; Cani, D.S., Institute of Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, C/o Spedali Civili, Piazzale Spedali Civili 1, Brescia BS, 25123, Italy; Cerini, M., Institute of Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, C/o Spedali Civili, Piazzale Spedali Civili 1, Brescia BS, 25123, Italy; Farina, D., Institute of Radiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy; Gavazzi, E., Institute of Radiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy; Maroldi, R., Institute of Radiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy; Adamo, M., Institute of Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, C/o Spedali Civili, Piazzale Spedali Civili 1, Brescia BS, 25123, Italy; Ammirati, E., De Gasperis Cardio Center, Transplant Center, Niguarda Hospital, Milan, Italy; Sinagra, G., Cardiovascular Department, Ospedali Riuniti, University of Trieste, Trieste, Italy; Lombardi, C.M., Institute of Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, C/o Spedali Civili, Piazzale Spedali Civili 1, Brescia BS, 25123, Italy; Metra, M., Institute of Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, C/o Spedali Civili, Piazzale Spedali Civili 1, Brescia BS, 25123, Italy","Importance: Virus infection has been widely described as one of the most common causes of myocarditis. However, less is known about the cardiac involvement as a complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Objective: To describe the presentation of acute myocardial inflammation in a patient with coronavirus disease 2019 (COVID-19) who recovered from the influenzalike syndrome and developed fatigue and signs and symptoms of heart failure a week after upper respiratory tract symptoms. Design, Setting, and Participant: This case report describes an otherwise healthy 53-year-old woman who tested positive for COVID-19 and was admitted to the cardiac care unit in March 2020 for acute myopericarditis with systolic dysfunction, confirmed on cardiac magnetic resonance imaging, the week after onset of fever and dry cough due to COVID-19. The patient did not show any respiratory involvement during the clinical course. Exposure: Cardiac involvement with COVID-19. Main Outcomes and Measures: Detection of cardiac involvement with an increase in levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitivity troponin T, echocardiography changes, and diffuse biventricular myocardial edema and late gadolinium enhancement on cardiac magnetic resonance imaging. Results: An otherwise healthy 53-year-old white woman presented to the emergency department with severe fatigue. She described fever and dry cough the week before. She was afebrile but hypotensive; electrocardiography showed diffuse ST elevation, and elevated high-sensitivity troponin T and NT-proBNP levels were detected. Findings on chest radiography were normal. There was no evidence of obstructive coronary disease on coronary angiography. Based on the COVID-19 outbreak, a nasopharyngeal swab was performed, with a positive result for SARS-CoV-2 on real-time reverse transcriptase-polymerase chain reaction assay. Cardiac magnetic resonance imaging showed increased wall thickness with diffuse biventricular hypokinesis, especially in the apical segments, and severe left ventricular dysfunction (left ventricular ejection fraction of 35%). Short tau inversion recovery and T2-mapping sequences showed marked biventricular myocardial interstitial edema, and there was also diffuse late gadolinium enhancement involving the entire biventricular wall. There was a circumferential pericardial effusion that was most notable around the right cardiac chambers. These findings were all consistent with acute myopericarditis. She was treated with dobutamine, antiviral drugs (lopinavir/ritonavir), steroids, chloroquine, and medical treatment for heart failure, with progressive clinical and instrumental stabilization. Conclusions and Relevance: This case highlights cardiac involvement as a complication associated with COVID-19, even without symptoms and signs of interstitial pneumonia.. © 2020 Cambridge University Press. All rights reserved.",,,"Pneumonia of Unknown Cause Ͽ China, , https://www.who.int/csr/don/05-january-2020-pneumonia-of-unkown-cause-china/en/, Accessed January 5, 2020; Novel Coronavirus Ͽ China, , https://www.who.int/csr/don/12-january-2020-novel-coronavirus-china/en/, Accessed January 12, 2020; Lu, R., Zhao, X., Li, J., Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding (2020) Lancet, 395 (10224), pp. 565-574. , http://dx.doi.org/10.1016/S0140-6736(20)30251-8, doi: PMID 32007145; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395 (10223), pp. 497-506. , http://dx.doi.org/10.1016/S0140-6736(20)30183-5, doi: PMID 31986264; Yu, C.M., Wong, R.S., Wu, E.B., Cardiovascular complications of severe acute respiratory syndrome (2006) Postgrad Med J, 82 (964), pp. 140-144. , http://dx.doi.org/10.1136/pgmj.2005.037515, doi: PMID 16461478; Friedrich, M.G., Sechtem, U., Schulz-Menger, J., Cardiovascular magnetic resonance in myocarditis: A JACC White Paper (2009) J Am Coll Cardiol, 53 (17), pp. 1475-1487. , http://dx.doi.org/10.1016/j.jacc.2009.02.007, doi: PMID 19389557; Young, B.E., Ong, S.W.X., Kalimuddin, S., Epidemiologic features and clinical course of patients infected with SARS-CoV-2 in Singapore (2020) JAMA, , http://jamanetwork.com/article.aspx?doi=10.1001/jama.2020.3204, Published online March 3, 2020. doi: PMID 32125362; Gao, J., Tian, Z., Yang, X., Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies (2020) Biosci Trends, 14 (1), pp. 72-73. , http://dx.doi.org/10.5582/bst.2020.01047, doi: PMID 32074550; Guan, W.J., Ni, Z.Y., Hu, Y., Clinical characteristics of coronavirus disease 2019 in China (2020) N Engl J Med, , http://dx.doi.org/10.1056/NEJMoa2002032, Published online February 28, doi: PMID 32109013; Xu, Z., Shi, L., Wang, Y., Pathological findings of COVID-19 associated with acute respiratory distress syndrome (2020) Lancet Respir Med, , http://dx.doi.org/10.1016/S2213-2600(20)30076-X, Published online February 18, doi: PMID 32085846; Fung, G., Luo, H., Qiu, Y., Yang, D., McManus, B., Myocarditis (2016) Circ Res, 118 (3), pp. 496-514. , http://dx.doi.org/10.1161/CIRCRESAHA.115.306573, doi: PMID 26846643; Esfandiarei, M., McManus, B.M., Molecular biology and pathogenesis of viral myocarditis (2008) Annu Rev Pathol, 3, pp. 127-155. , http://dx.doi.org/10.1146/annurev.pathmechdis.3.121806.151534, doi: PMID 18039131; Yang, X., Yu, Y., Xu, J., Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: A single-centered, retrospective, observational study (2020) Lancet Respir Med, , http://dx.doi.org/10.1016/S2213-2600(20)30079-5, Published online February 24, doi: PMID 32105632; Rahman, J.E., Helou, E.F., Gelzer-Bell, R., Noninvasive diagnosis of biopsy-proven cardiac amyloidosis (2004) J Am Coll Cardiol, 43 (3), pp. 410-415. , http://dx.doi.org/10.1016/j.jacc.2003.08.043, doi: PMID 15013123; Liu, P.P., Mason, J.W., Advances in the understanding of myocarditis (2001) Circulation, 104 (9), pp. 1076-1082. , http://dx.doi.org/10.1161/hc3401.095198, doi: PMID 11524405","Metra, M.; Institute of Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, C/o Spedali Civili, Piazzale Spedali Civili 1, Italy; email: metramarco@libero.it",,American Medical Association,23806583,,,32219357,English,JAMA Cardiol.,Article,Article in Press,Open Access,Scopus,2-s2.0-85082499194,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Haider N., Yavlinsky A., Simons D., Osman A.Y., Ntoumi F., Zumla A., Kock R.",55205099300;57215665289;57215666095;57214653249;7004125689;7006170723;57202637161;,Passengers' destinations from China: Low risk of Novel Coronavirus (2019-nCoV) transmission into Africa and South America,2020,Epidemiology and Infection,,, e41,,,,3,10.1017/S0950268820000424,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081585939&doi=10.1017%2fS0950268820000424&partnerID=40&md5=395fb8493adaccd0b3b0df7a2f904a8c,"Royal Veterinary College, University of London, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire, United Kingdom; Institute of Health Informatics, University College London, London, United Kingdom; Fondation Congolaise Pour la Recherche Médicale (FCRM), Brazzaville, Congo; Institute for Tropical Medicine, University of Tübingen, Tubingen, Germany; Department of Infection, Division of Infection and Immunity, UCL Centre for Clinical Microbiology, Royal Free Campus, London, United Kingdom; NIHR Biomedical Research Centre, UCL Hospitals NHS Foundation Trust, London, United Kingdom","Haider, N., Royal Veterinary College, University of London, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire, United Kingdom; Yavlinsky, A., Institute of Health Informatics, University College London, London, United Kingdom; Simons, D., Royal Veterinary College, University of London, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire, United Kingdom; Osman, A.Y., Royal Veterinary College, University of London, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire, United Kingdom; Ntoumi, F., Fondation Congolaise Pour la Recherche Médicale (FCRM), Brazzaville, Congo, Institute for Tropical Medicine, University of Tübingen, Tubingen, Germany; Zumla, A., Department of Infection, Division of Infection and Immunity, UCL Centre for Clinical Microbiology, Royal Free Campus, London, United Kingdom, NIHR Biomedical Research Centre, UCL Hospitals NHS Foundation Trust, London, United Kingdom; Kock, R., Royal Veterinary College, University of London, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire, United Kingdom","Novel Coronavirus (2019-nCoV [SARS-COV-2]) was detected in humans during the last week of December 2019 at Wuhan city in China, and caused 24 554 cases in 27 countries and territories as of 5 February 2020. The objective of this study was to estimate the risk of transmission of 2019-nCoV through human passenger air flight from four major cities of China (Wuhan, Beijing, Shanghai and Guangzhou) to the passengers' destination countries. We extracted the weekly simulated passengers' end destination data for the period of 1-31 January 2020 from FLIRT, an online air travel dataset that uses information from 800 airlines to show the direct flight and passengers' end destination. We estimated a risk index of 2019-nCoV transmission based on the number of travellers to destination countries, weighted by the number of confirmed cases of the departed city reported by the World Health Organization (WHO). We ranked each country based on the risk index in four quantiles (4th quantile being the highest risk and 1st quantile being the lowest risk). During the period, 388 287 passengers were destined for 1297 airports in 168 countries or territories across the world. The risk index of 2019-nCoV among the countries had a very high correlation with the WHO-reported confirmed cases (0.97). According to our risk score classification, of the countries that reported at least one Coronavirus-infected pneumonia (COVID-19) case as of 5 February 2020, 24 countries were in the 4th quantile of the risk index, two in the 3rd quantile, one in the 2nd quantile and none in the 1st quantile. Outside China, countries with a higher risk of 2019-nCoV transmission are Thailand, Cambodia, Malaysia, Canada and the USA, all of which reported at least one case. In pan-Europe, UK, France, Russia, Germany and Italy; in North America, USA and Canada; in Oceania, Australia had high risk, all of them reported at least one case. In Africa and South America, the risk of transmission is very low with Ethiopia, South Africa, Egypt, Mauritius and Brazil showing a similar risk of transmission compared to the risk of any of the countries where at least one case is detected. The risk of transmission on 31 January 2020 was very high in neighbouring Asian countries, followed by Europe (UK, France, Russia and Germany), Oceania (Australia) and North America (USA and Canada). Increased public health response including early case recognition, isolation of identified case, contract tracing and targeted airport screening, public awareness and vigilance of health workers will help mitigate the force of further spread to naïve countries. © 2020 The Author(s).",,"COVID-19; severe acute respiratory syndrome coronavirus 2; Africa; airport; aviation; Betacoronavirus; China; communicable disease; Coronavirus infection; emporiatrics; epidemic; health survey; human; risk assessment; South America; virus pneumonia; Africa; Air Travel; Airports; Betacoronavirus; China; Communicable Diseases, Imported; Coronavirus Infections; Disease Outbreaks; Humans; Pneumonia, Viral; Population Surveillance; Risk Assessment; South America; Travel Medicine","Li, Q., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) The New England Journal of Medicine, pp. 1-9; Chen, N., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study (2020) Lancet (London, England), 6736, pp. 1-7; (2020), ProMED Undiagnosed pneumonia-China (HU) (01): Wildlife sales, market closed, RFI; Wu, J.T., Leung, K., Leung, G.M., Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: A modelling study (2020) The Lancet, p. 6736. , Published online: January 2020. doi; Bogoch, I.I., Potential for global spread of a novel coronavirus from China (2020) Journal of Travel Medicine, , http://doi.org/10.1093/jtm/taaa011, Published online: 2020; Johns Hopkins University. Coronavirus COVID-19 Global Cases by Johns Hopkins CSSE; Rothe, C., Transmission of 2019-nCoV infection from an asymptomatic contact in Germany (2020) The New England Journal of Medicine, pp. 2019-2020; Wang, X., Tracing the largest seasonal migration on earth (2014) ArXiv, , Published online: November 2014. arXiv:1411.0983; Brautigam, D., Xiaoyang, T., Xia, Y., What kinds of Chinese 'geese' are flying to Africa Evidence from Chinese manufacturing firms (2018) Journal of African Economies, 27, pp. i29-i51; Wang, J., Yang, H., Wang, H., The evolution of China's international aviation markets from a policy perspective on air passenger flows (2019) Sustainability (Switzerland), 11, p. 3566; Chinazzi, M., (2020), pp. 1-7. , Preliminary assessment of the international spreading risk associated with the 2019 novel Coronavirus (2019-nCoV) outbreak in Wuhan City; Huff, A., FLIRT-ing with Zika: A web application to predict the movement of infected travelers validated against the current zika virus epidemic (2016) PLoS Currents, , Edition 1; Alliance, E.H., (2016), http://flirt.eha.io/, FLIRT: A product of EcoHealth alliance. Available at; (2020), WHO Novel coronavirus(2019-nCoV) situation report-1-14; (2020), Johns Hopkins Center for Health Security Global health security index; Hui, D.S., The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health-the latest 2019 novel coronavirus outbreak in Wuhan, China (2020) International Journal of Infectious Diseases, 91, pp. 264-266; McCloskey, B., Heymann, D.L., SARS to novel coronavirus-old lessons and new lessons (2020) Epidemiology and Infection, 148, pp. 3-6","Haider, N.; Royal Veterinary College, University of London, Hawkshead Lane, United Kingdom; email: nhaider@rvc.ac.uk",,Cambridge University Press,9502688,,EPINE,32100667,English,Epidemiol. Infect.,Article,Article in Press,Open Access,Scopus,2-s2.0-85081585939,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Lau S.K.P., Li K.S.M., Luk H.K.H., He Z., Teng J.L.L., Yuen K.-Y., Wernery U., Woo P.C.Y.",7401596211;24759122500;56513568500;57195429564;7202560229;36078079100;7005483197;7201801340;,Middle east respiratory syndrome coronavirus antibodies in bactrian and hybrid camels from Dubai,2020,mSphere,5,1, e00898,,,,1,10.1128/mSphere.0898-19,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078229633&doi=10.1128%2fmSphere.0898-19&partnerID=40&md5=b6e92097d0c8abc270348b9b2c70e2b2,"State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong; Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong; Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, The University of Hong Kong, Hong Kong; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong; Central Veterinary Research Laboratory, Dubai, United Arab Emirates","Lau, S.K.P., State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, The University of Hong Kong, Hong Kong, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong; Li, K.S.M., Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong; Luk, H.K.H., Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong; He, Z., Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong; Teng, J.L.L., State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong; Yuen, K.-Y., State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, The University of Hong Kong, Hong Kong, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong; Wernery, U., Central Veterinary Research Laboratory, Dubai, United Arab Emirates; Woo, P.C.Y., State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong, Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong, Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, The University of Hong Kong, Hong Kong, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong","So far, dromedary camels are the only known animal reservoir for Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV). Previous published serological studies showed that sera of Bactrian camels were all negative for MERSCoV antibodies. However, a recent study revealed that direct inoculation of Bactrian camels intranasally with MERS-CoV can lead to infection with abundant virus shedding and seroconversion. In this study, we examined the presence of MERS-CoV antibodies in Bactrian and hybrid camels in Dubai, the United Arab Emirates (where dromedaries are also present), and Bactrian camels in Xinjiang, China (where dromedaries are absent). For the 29 serum samples from Bactrian camels in Dubai tested by the MERS-CoV spike (S) protein-based enzyme-linked immunosorbent assay (SELISA) and neutralization antibody test, 14 (48%) and 12 (41%), respectively, were positive for MERS-CoV antibodies. All the 12 serum samples that were positive with the neutralization antibody test were also positive for the S-ELISA. For the 11 sera from hybrid camels in Dubai tested with the S-ELISA and neutralization antibody test, 6 (55%) and 9 (82%), respectively, were positive for MERS-CoV antibodies. All the 6 serum samples that were positive for the S-ELISA were also positive with the neutralization antibody test. There was a strong correlation between the antibody levels detected by S-ELISA and neutralizing antibody titers, with a Spearman coefficient of 0.6262 (P<0.0001; 95% confidence interval, 0.5062 to 0.7225). All 92 Bactrian camel serum samples from Xinjiang were negative for MERS-CoV antibodies tested using both S-ELISA and the neutralization antibody test. Bactrian and hybrid camels are potential sources of MERS-CoV infection. IMPORTANCE Since its first appearance in 2012, Middle East respiratory syndrome (MERS) has affected >25 countries, with >2,400 cases and an extremely high fatality rate of >30%. The total number of mortalities due to MERS is already greater than that due to severe acute respiratory syndrome. MERS coronavirus (MERS-CoV) has been confirmed to be the etiological agent. So far, dromedaries are the only known animal reservoir for MERS-CoV. Previously published serological studies showed that sera of Bactrian camels were all negative for MERS-CoV antibodies. In this study, we observed that 41% of the Bactrian camel sera and 55% of the hybrid camel sera from Dubai (where dromedaries are also present), but none of the sera from Bactrian camels in Xinjiang (where dromedaries are absent), were positive for MERS-CoV antibodies. Based on these results, we conclude that in addition to dromedaries, Bactrian and hybrid camels are also potential sources of MERS-CoV infection. © 2020 Lau et al.",Antibody; Bactrian camel; Hybrid camel; MERS coronavirus,Middle East respiratory syndrome coronavirus antibody; neutralizing antibody; unclassified drug; virus antibody; virus spike protein; antibody detection; antibody titer; Article; Bactrian camel; China; controlled study; correlation analysis; Dubai; enzyme linked immunosorbent assay; hybrid; Middle East respiratory syndrome coronavirus; nonhuman; serum; virus neutralization,"Zaki, A.M., van Boheemen, S., Bestebroer, T.M., Osterhaus, A.D., Fouchier, R.A., Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia (2012) N Engl J Med, 367, pp. 1814-1820. , https://doi.org/10.1056/NEJMoa1211721; Raj, V.S., Mou, H., Smits, S.L., Dekkers, D.H., Müller, M.A., Dijkman, R., Muth, D., Haagmans, B.L., Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC (2013) Nature, 495, pp. 251-254. , https://doi.org/10.1038/nature12005; Reusken, C.B., Haagmans, B.L., Müller, M.A., Gutierrez, C., Godeke, G.J., Meyer, B., Muth, D., Koopmans, M.P., Middle East respiratory syndrome corona-virus neutralising serum antibodies in dromedary camels: A comparative serological study (2013) Lancet Infect Dis, 13, pp. 859-866. , https://doi.org/10.1016/S1473-3099(13)70164-6; Lau, S.K., Wernery, R., Wong, E.Y., Joseph, S., Tsang, A.K., Patteril, N.A., Elizabeth, S.K., Woo, P.C., Polyphyletic origin ofMERS coronaviruses and isolation ofa novel clade A strain from dromedary camels in the United Arab Emirates (2016) Emerg Microbes Infect, 5. , https://doi.org/10.1038/emi.2016.129; Chu, D.K., Hui, K.P., Perera, R.A., Miguel, E., Niemeyer, D., Zhao, J., Channap-Panavar, R., Peiris, M., MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity (2018) Proc Natl Acad SciUSA, 115, pp. 3144-3149. , https://doi.org/10.1073/pnas.1718769115; Lau, S.K., Li, K.S., Tsang, A.K., Lam, C.S., Ahmed, S., Chen, H., Chan, K.H., Yuen, K.Y., Genetic characterization of Betacoronavirus lineage C viruses in bats reveals marked sequence divergence in the spike protein of Pipistrellus bat coronavirus HKU5 in Japanese pipistrelle: Implications for the origin of the novel Middle East respiratory syndrome coronavirus (2013) J Virol, 87, pp. 8638-8650. , https://doi.org/10.1128/JVI.01055-13; Lau, S.K., Zhang, L., Luk, H.K., Xiong, L., Peng, X., Li, K.S., He, X., Woo, P.C., Receptor usage of a novel bat lineage C betacoronavirus reveals evolution of MERS-related coronavirus spike proteins for human DPP4 binding (2018) J Infect Dis, 218, pp. 197-207. , https://doi.org/10.1093/infdis/jiy018; Corman, V.M., Kallies, R., Philipps, H., Göpner, G., Müller, M.A., Eckerle, I., Brünink, S., Drexler, J.F., Characterization of a novel betacoronavirus related to Middle East respiratory syndrome corona-virus in European hedgehogs (2014) J Virol, 88, pp. 717-724. , https://doi.org/10.1128/JVI.01600-13; Lau, S.K., Luk, H.K., Wong, A.C., Fan, R.Y., Lam, C.S., Li, K.S., Ahmed, S.S., Yuen, K.Y., Identification of a novel betacoronavirus (Merbecovirus) in Amur hedgehogs from China (2019) Viruses, 11, p. 980. , https://doi.org/10.3390/v11110980; Chan, S.M., Damdinjav, B., Perera, R.A., Chu, D.K., Khishgee, B., Enkhbold, B., Poon, L.L., Peiris, M., Absence of MERS-coronavirus in Bactrian camels, Southern Mongolia, November 2014 (2015) Emerg Infect Dis, 21, pp. 1269-1271. , https://doi.org/10.3201/eid2107.150178; Liu, R., Wen, Z., Wang, J., Ge, J., Chen, H., Bu, Z., Absence of Middle East respiratory syndrome coronavirus in Bactrian camels in the West Inner Mongolia Autonomous Region of China: Surveillance study results from July 2015 (2015) Emerg Microbes Infect, 4. , https://doi.org/10.1038/emi.2015.73; Meyer, B., Müller, M.A., Corman, V.M., Reusken, C.B., Ritz, D., Godeke, G.J., Lattwein, E., Drosten, C., Antibodies against MERS coronavirus in dromedary camels, United Arab Emirates, 2003 and 2013 (2014) Emerg Infect Dis, 20, pp. 552-559. , https://doi.org/10.3201/eid2004.131746; Miguel, E., Perera, R.A., Baubekova, A., Chevalier, V., Faye, B., Akhmetsadykov, N., Ng, C.Y., Peiris, M., Absence of Middle East respiratory syndrome coronavirus in camelids, Kazakhstan, 2015 (2016) Emerg Infect Dis, 22, pp. 555-557. , https://doi.org/10.3201/eid2203.151284; Shirato, K., Azumano, A., Nakao, T., Hagihara, D., Ishida, M., Tamai, K., Yamazaki, K., Matsuyama, S., Middle East respiratory syndrome coronavirus infection not found in camels in Japan (2015) Jpn J Infect Dis, 68, pp. 256-258. , https://doi.org/10.7883/yoken.JJID.2015.094; Adney, D.R., Letko, M., Ragan, I.K., Scott, D., van Doremalen, N., Bowen, R.A., Munster, V.J., Bactrian camels shed large quantities of Middle East respiratory syndrome coronavirus (MERS-CoV) after experimental infection (2019) Emerg Microbes Infect, 8, pp. 717-723. , https://doi.org/10.1080/22221751.2019.1618687; Wang, L., Teng, J.L., Lau, S.K., Sridhar, S., Fu, H., Gong, W., Li, M., Wang, L., Transmission of a novel genotype of hepatitis E virus from Bactrian camels to cynomolgus macaques (2019) J Virol, 93. , https://doi.org/10.1128/JVI.02014-18; Wernery, U., Rasoul, I.H., Wong, E.Y., Joseph, M., Chen, Y., Jose, S., Tsang, A.K., Woo, P.C., A phylogenetically distinct MERS coronavirus detected in a dromedary calf from a closed dairy herd in Dubai with rising seroprevalence along age (2015) Emerg Microbes Infect, 4. , https://doi.org/10.1038/emi.2015.74; Woo, P.C., Lau, S.K., Wernery, U., Wong, E.Y., Tsang, A.K., Johnson, B., Yip, C.C., Yuen, K.Y., Novel betacoronavirus in dromedaries of the Middle East, 2013 (2014) Emerg Infect Dis, 20, pp. 560-572. , https://doi.org/10.3201/eid2004.131769; Yong, C.Y., Ong, H.K., Yeap, S.K., Ho, K.L., Tan, W.S., Recent advances in the vaccine development against Middle East respiratory syndrome-coronavirus (2019) Front Microbiol, 10, p. 1781. , https://doi.org/10.3389/fmicb.2019.01781; Haagmans, B.L., van den Brand, J.M., Raj, V.S., Volz, A., Wohlsein, P., Smits, S.L., Schipper, D., Osterhaus, A.D., An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels (2016) Science, 351, pp. 77-81. , https://doi.org/10.1126/science.aad1283; Adney, D.R., Wang, L., van Doremalen, N., Shi, W., Zhang, Y., Kong, W.P., Miller, M.R., Munster, V.J., Efficacy of an adjuvanted Middle East respiratory syndrome coronavirus spike protein vaccine in dromedary camels and alpacas (2019) Viruses, 11, p. 212. , https://doi.org/10.3390/v11030212; Alharbi, N.K., Padron-Regalado, E., Thompson, C.P., Kupke, A., Wells, D., Sloan, M.A., Grehan, K., Gilbert, S.C., ChAdOx1 and MVA based vaccine candidates against MERS-CoV elicit neutralising antibodies and cellular immune responses in mice (2017) Vaccine, 35, pp. 3780-3788. , https://doi.org/10.1016/j.vaccine.2017.05.032; Muthumani, K., Falzarano, D., Reuschel, E.L., Tingey, C., Flingai, S., Villarreal, D.O., Wise, M., Weiner, D.B., A synthetic consensus anti-spike protein DNA vaccine induces protective immunity against Middle East respiratory syndrome coronavirus in nonhuman primates (2015) Sci Transl Med, 7. , https://doi.org/10.1126/scitranslmed.aac7462, 301ra132","Wernery, U.; Central Veterinary Research LaboratoryUnited Arab Emirates; email: cvrl@cvrl.ae",,American Society for Microbiology,23795042,,,31969478,English,mSphere,Article,Final,,Scopus,2-s2.0-85078229633,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Guan C.S., Lv Z.B., Yan S., Du Y.N., Chen H., Wei L.G., Xie R.M., Chen B.D.",57215824107;56386749600;57215815927;57215815015;57215821466;55598504900;7202459154;15134915800;,Imaging Features of Coronavirus disease 2019 (COVID-19): Evaluation on Thin-Section CT,2020,Academic Radiology,,,,,,,,10.1016/j.acra.2020.03.002,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081977217&doi=10.1016%2fj.acra.2020.03.002&partnerID=40&md5=d6060c4add259a1621dd44ffb38aab74,"Department of Radiology, Beijing Ditan Hospital, Capital Medical University, No.8 Jingshun East Street, Chaoyang District, Beijing, China","Guan, C.S., Department of Radiology, Beijing Ditan Hospital, Capital Medical University, No.8 Jingshun East Street, Chaoyang District, Beijing, China; Lv, Z.B., Department of Radiology, Beijing Ditan Hospital, Capital Medical University, No.8 Jingshun East Street, Chaoyang District, Beijing, China; Yan, S., Department of Radiology, Beijing Ditan Hospital, Capital Medical University, No.8 Jingshun East Street, Chaoyang District, Beijing, China; Du, Y.N., Department of Radiology, Beijing Ditan Hospital, Capital Medical University, No.8 Jingshun East Street, Chaoyang District, Beijing, China; Chen, H., Department of Radiology, Beijing Ditan Hospital, Capital Medical University, No.8 Jingshun East Street, Chaoyang District, Beijing, China; Wei, L.G., Department of Radiology, Beijing Ditan Hospital, Capital Medical University, No.8 Jingshun East Street, Chaoyang District, Beijing, China; Xie, R.M., Department of Radiology, Beijing Ditan Hospital, Capital Medical University, No.8 Jingshun East Street, Chaoyang District, Beijing, China; Chen, B.D., Department of Radiology, Beijing Ditan Hospital, Capital Medical University, No.8 Jingshun East Street, Chaoyang District, Beijing, China","Rationale and Objectives: To retrospectively analyze the chest imaging findings in patients with coronavirus disease 2019 (COVID-19) on thin-section CT. Materials and Methods: Fifty-three patients with confirmed COVID-19 infection underwent thin-section CT examination. Two chest radiologists independently evaluated the imaging in terms of distribution, ground-glass opacity (GGO), consolidation, air bronchogram, stripe, enlarged mediastinal lymph node, and pleural effusion. Results: Fourty-seven cases (88.7%) had findings of COVID-19 infection, and the other six (11.3%) were normal. Among the 47 cases, 78.7% involved both lungs, and 93.6% had peripheral infiltrates distributed along the subpleural area. All cases showed GGO, 59.6% of which were round and 40.4% patchy. Other imaging features included “crazy-paving pattern” (89.4%), consolidation (63.8%), and air bronchogram (76.6%). Air bronchograms were observed within GGO (61.7%) and consolidation (70.3%). Neither enlarged mediastinal lymph nodes nor pleural effusion were present. Thirty-three patients (62.3%) were followed an average interval of 6.2 ± 2.9 days. The lesions increased in 75.8% and resorbed in 24.2% of patients. Conclusion: COVID-19 showed the pulmonary lesions in patients infected with COVID-19 were predominantly distributed peripherally in the subpleural area. © 2020 The Association of University Radiologists",Coronavirus; Lung; Multidetector computed tomography; Pneumonia,,"World Health Organization, (2020), https://www.who.int/emergencies/diseases/novel-coronavirus-2019, Available at: Accessed January 21; (2020), https://talk.ictvonline.org/, International Committee on Taxonomy of Viruses. Available at: Retrieved February 11; World Health Organization, (2020), https://www.who.int/news-room/detail/12-02-2020-world-experts-and-funders-set-priorities-for-covid-19-research, Available at: Accessed February 12; Hansell, D.M., Bankier, A.A., MacMahon, H., Fleischner society: glossary of terms for thoracic imaging (2008) Radiology, 246, pp. 697-722; Gong, S.R., Bao, L.L., The battle against SARS and MERS coronaviruses: reservoirs and animal models (2018) Animal Model Exp Med, 1, pp. 125-133; Nassar, M.S., Bakhrebah, M.A., Meo, S.A., Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection: epidemiology, pathogenesis and clinical characteristics (2018) Eur Rev Med Pharmacol Sci, 22, pp. 4956-4961; (2020), http://bgs.satcm.gov.cn/zhengcewenjian/2020-01-28/12576.html, General Office of National Health Committee. Office of state administration of traditional Chinese Medicine. Available at: Accessed January 28; Xu, Z., Shi, L., Wang, Y., Pathological findings of COVID-19 associated with acute respiratory distress syndrome (2020) Lancet Respir Med, , pii: S2213-2600(20)30076-X; Ding, Y., Wang, H., Shen, H., The clinical pathology of severe acute respiratory syndrome (SARS): a report from China (2003) J Pathol, 200, pp. 282-289; Zhang, L.J., Zhang, S.J., Meng, X., A clnicopathological study on 3 cases of severe acute respiratory syndrome (2003) Clin J Pathol, 32, pp. 201-204; Nicholls, J.M., Poon, L.L., Lee, K.C., Lung pathology of fatal severe acute respiratory syndrome (2003) Lancet, 361, pp. 1773-1778; Ng, D.L., Al Hosani, F., Keating, M.K., Clinicopathologic, immunohistochemical, and ultrastructural findings of a fatal case of Middle East respiratory syndrome coronavirus infection in the United Arab Emirates, April 2014 (2016) Am J Pathol, 186, pp. 652-658; Alsaad, K.O., Hajeer, A.H., Al Balwi, M., Histopathology of Middle East respiratory syndrome coronovirus (MERSvCoV) infection – clinicopathological and ultrastructural study (2018) Histopathology, 72, pp. 516-524; de Wit, E., Rasmussen, A.L., Falzarano, D., Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques (2013) Proc Natl Acad Sci, 110, pp. 16598-16603; Baseler, L.J., Falzarano, D., Scott, D.P., An acute immune response to Middle East respiratory syndrome coronavirus replication contributes to viral pathogenicity (2016) Am J Pathol, 186, pp. 630-638; Yao, Y., Bao, L., Deng, W., An animal model of MERS Produced by infection of rhesus macaques With MERS coronavirus (2014) J Infect Dis, 209, pp. 236-242; Peiris, J.S., Chu, C.M., Cheng, V.C., Clinical progression and viral load in a community outbreak of coronavirus-associated SARS Pneumonia: a prospective study (2003) Lancet, 361, pp. 1767-1772; Hon, K.L., Leung, C.W., Cheng, W.T., Clinical presentations and outcome of severe acute respiratory syndrome in children (2003) Lancet, 361, pp. 1701-1703; Das, K.M., Lee, E.Y., Enani, M.A., CT correlation with outcomes in 15 patients with acute Middle East Respiratory Syndrome Coronavirus (2015) AJR Am J Roentgenol, 204, pp. 736-742; Ajlan, A.M., Ahyad, R.A., Jamjoom, L.G., Middle East respiratory syndrome coronavirus (MERS-CoV) infection: chest CT findings (2014) AJR Am J Roentgenol, 203, pp. 782-787; Wong, K.T., Antonio, G.E., Hui, D.S., Servere acute respiratory syndrome: radiographic appearances and pattern of progression in 138 patinets (2003) Radiology, 228, pp. 401-406","Chen, B.D.; Department of Radiology, Beijing Ditan Hospital, Capital Medical University, No.8 Jingshun East Street, Chaoyang District, China; email: budongchen@sina.com",,Elsevier USA,10766332,,ARADF,,English,Acad. Radiol.,Article,Article in Press,Open Access,Scopus,2-s2.0-85081977217,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Fung J., Lau S.K.P., Woo P.C.Y.",57204950810;7401596211;7201801340;,Antigen capture enzyme-linked immunosorbent assay for detecting middle east respiratory syndrome coronavirus in humans,2020,Methods in Molecular Biology,2099,,,89,97,,,10.1007/978-1-0716-0211-9_7,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077340905&doi=10.1007%2f978-1-0716-0211-9_7&partnerID=40&md5=02ab561c66c28dd240ca72a2008e5a4b,"Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong; Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong","Fung, J., Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong; Lau, S.K.P., Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong, Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong; Woo, P.C.Y., Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong, Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong","The Middle East respiratory syndrome (MERS) is the second novel zoonotic disease infecting humans caused by coronavirus (CoV) in this century. To date, more than 2200 laboratory-confirmed human cases have been identified in 27 countries, and more than 800 MERS-CoV associated deaths have been reported since its outbreak in 2012. Rapid laboratory diagnosis of MERS-CoV is the key to successful containment and prevention of the spread of infection. Though the gold standard for diagnosing MERS-CoV infection in humans is still nucleic acid amplification test (NAAT) of the up-E region, an antigen capture enzyme-linked immunosorbent assay (ELISA) could also be of use for early diagnosis in less developed locations. In the present method, a step-by-step guide to perform a MERS-CoV nucleocapsid protein (NP) capture ELISA using two NP-specific monoclonal antibodies is provided for readers to develop their in-house workflow or diagnostic kit for clinical use and for mass-screening project of animals (e.g., dromedaries and bats) to better understand the spread and evolution of the virus. © Springer Science+Business Media, LLC, part of Springer Nature 2020.",Antigen capture ELISA; Clinical diagnosis; Immunoassay; MERS-CoV; Molecular detection; Nucleocapsid protein,,"(2018) W.H.O., MERS Situation Update, p. 1. , July, 2018, World Health Organization: World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland; (2018) Laboratory Testing for Middle East Respiratory Syndrome Coronavirus, 2018, p. 8. , January; Chen, Y., A sensitive and specific antigen detection assay for Middle East respiratory syndrome coronavirus (2015) Emerg Microbes Infect, 4 (4); Corman, V.M., Detection of a novel human coronavirus by real-time reverse-tran-scription polymerase chain reaction (2012) Euro Surveill, 17 (39); Corman, V.M., Assays for laboratory confirmation of novel human coronavirus (HCoV-EMC) infections (2012) Euro Surveill, 17 (49); Muller, M.A., Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: A nationwide, cross-sectional, serological study (2015) Lancet Infect Dis, 15 (6), p. 629; Perera, R.A., Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt, June 2013 (2013) Euro Surveill, 18 (36). , pii=20574; Saeidnia, S., Abdollahi, M., Are other fluorescent tags used instead of ethidium bromide safer? (2013) Daru, 21 (1), p. 71; Drosten, C., Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection (2013) Lancet Infect Dis, 13 (9), pp. 745-751; Kapoor, M., Clinical and laboratory findings of the first imported case of Middle East respiratory syndrome coronavirus to the United States (2014) Clin Infect Dis, 59 (11), pp. 1511-1518; Alagaili, A.N., Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia (2014) Mbio, 5 (2), p. e00884; Chen, Y., A highly specific rapid antigen detection assay for on-site diagnosis of MERS (2016) J Infect, 73 (1), pp. 82-84; Woo, P.C.Y., Rapid detection of MERS coronavirus-like viruses in bats: Pote1n-tial for tracking MERS coronavirus transmission and animal origin (2018) Emerg Microbes Infect, 7 (1), p. 18; Lau, S.K., Genetic characterization of Betacoronavirus lineage C viruses in bats reveals marked sequence divergence in the spike protein of pipistrellus bat coronavirus HKU5 in Japanese pipistrelle: Implications for the origin of the novel Middle East respiratory syndrome coronavirus (2013) J Virol, 87 (15), pp. 8638-8650; Yuan, Q., Differential diagnosis of pandemic (H1N1) 2009 infection by detection of haemagglutinin with an enzyme-linked immunoassay (2011) Clin Microbiol Infect, 17 (10), pp. 1574-1580; Lau, S.K., SARS coronavirus detection methods (2005) Emerg Infect Dis, 11 (7), pp. 1108-1111; Lau, S.K., Detection of severe acute respiratory syndrome (SARS) coronavirus nucleocapsid protein in sars patients by enzyme-linked immunosorbent assay (2004) J Clin Microbiol, 42 (7), pp. 2884-2889; Chan, J.F., Differential cell line susceptibility to the emerging novel human betacoronavirus 2c EMC/2012: Implications for disease pathogenesis and clinical manifestation (2013) J Infect Dis, 207 (11), pp. 1743-1752; Chan, K.H., Cross-reactive antibodies in convalescent SARS patients’ sera against the emerging novel human coronavirus EMC (2012) by both immunofluorescent and neutralizing antibody tests (2013) J Infect, 67 (2), pp. 130-140","Woo, P.C.Y.; Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, The University of Hong KongHong Kong; email: pcywoo@hku.hk",,Humana Press Inc.,10643745,,,31883089,English,Methods Mol. Biol.,Book Chapter,Final,Open Access,Scopus,2-s2.0-85077340905,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Channappanavar R., Perlman S.",35309748500;57204567845;,Evaluation of activation and inflammatory activity of myeloid cells during pathogenic human coronavirus infection,2020,Methods in Molecular Biology,2099,,,195,204,,,10.1007/978-1-0716-0211-9_15,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077334544&doi=10.1007%2f978-1-0716-0211-9_15&partnerID=40&md5=6ff55e8e3b37203c6d3afc536000e37a,"Department of Acute and Tertiary Care, University of Tennessee Health Science Center, Memphis, TN, United States; Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN, United States; Institute for the Study of Host-Pathogen Systems, University of Tennessee Health Science Center, Memphis, TN, United States; Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, United States; Department of Pediatrics, University of Iowa, Iowa City, IA, United States; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China","Channappanavar, R., Department of Acute and Tertiary Care, University of Tennessee Health Science Center, Memphis, TN, United States, Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN, United States, Institute for the Study of Host-Pathogen Systems, University of Tennessee Health Science Center, Memphis, TN, United States; Perlman, S., Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, United States, Department of Pediatrics, University of Iowa, Iowa City, IA, United States, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China","Innate immune cells play a vital role in mounting an effective host response to a variety of pathogen challenges. Myeloid cells such as neutrophils and monocyte-macrophages are major innate leukocytes that orchestrate protective immunity to viral lung infections. However, a dysregulated cytokine response can promote excessive infiltration and robust pro-inflammatory activity of neutrophils and monocyte-macrophages, leading to fatal disease. Following virus infection, the beneficial or deleterious role of infiltrating neutrophils and monocyte-macrophages is determined largely by their ability to secrete inflammatory cytokines and chemokines. A majority of studies use the total number of infiltrating cells and their activation status as measures to demonstrate their role during an infection. Consequently, the ability of neutrophils and Inflammatory Monocyte Macrophages (IMMs) to secrete inflammatory cytokines and chemokines, and its correlation with the disease severity, is not well defined. In this chapter, we report useful markers to identify lung infiltrating innate immune cells and define their activation status. We also describe a simple method to measure intracellular cytokine production to evaluate the inflammatory activity of neutrophils and IMMs in a mouse model of human coronavirus infection. © Springer Science+Business Media, LLC, part of Springer Nature 2020.",Coronavirus; Cytokines and chemokines; Inflammatory monocyte-macrophages; Lungs; Neutrophils,,"Shi, C., Pamer, E.G., Monocyte recruitment during infection and inflammation (2011) Nat Rev Immunol, 11 (11), pp. 762-774. , https://doi.org/10.1038/nri3070; Camp, J.V., Jonsson, C.B., A role for neutrophils in viral respiratory disease (2017) Front Immunol, 8, p. 550. , https://doi.org/10.3389/fimmu.2017.00550; Hayashi, F., Means, T.K., Luster, A.D., Toll-like receptors stimulate human neutrophil function (2003) Blood, 102 (7), pp. 2660-2669. , https://doi.org/10.1182/blood-2003-04-1078; Prince, L.R., Whyte, M.K., Sabroe, I., Parker, L.C., The role of TLRs in neutrophil activation (2011) Curr Opin Pharmacol, 11 (4), pp. 397-403. , https://doi.org/10.1016/j.coph.2011.06.007; Malmgaard, L., Melchjorsen, J., Bowie, A.G., Mogensen, S.C., Paludan, S.R., Viral activation of macrophages through TLR-dependent and-independent pathways (2004) J Immunol, 173 (11), pp. 6890-6898; Hashimoto, Y., Moki, T., Takizawa, T., Shiratsuchi, A., Nakanishi, Y., Evidence for phagocytosis of influenza virus-infected, apoptotic cells by neutrophils and macrophages in mice (2007) J Immunol, 178 (4), pp. 2448-2457; Gralinski, L.E., Sheahan, T.P., Morrison, T.E., Menachery, V.D., Jensen, K., Leist, S.R., Whitmore, A., Baric, R.S., Complement activation contributes to severe acute respiratory syndrome coronavirus pathogenesis (2018) Mbio, 9 (5). , https://doi.org/10.1128/mBio.01753-18; Channappanavar, R., Fehr, A.R., Vijay, R., Mack, M., Zhao, J., Meyerholz, D.K., Perlman, S., Dys-regulated type I interferon and inflammatory monocyte-macrophage responses cause lethal pneumonia in SARS-CoV-infected mice (2016) Cell Host Microbe, 19 (2), pp. 181-193. , https://doi.org/10.1016/j.chom.2016.01.007; Davidson, S., Crotta, S., McCabe, T.M., Wack, A., Pathogenic potential of interferon alphabeta in acute influenza infection (2014) Nat Commun, 5. , https://doi.org/10.1038/ncomms4864; Tate, M.D., Deng, Y.M., Jones, J.E., Anderson, G.P., Brooks, A.G., Reading, P.C., Neutrophils ameliorate lung injury and the development of severe disease during influenza infection (2009) J Immunol, 183 (11), pp. 7441-7450. , https://doi.org/10.4049/jimmunol.0902497; Brandes, M., Klauschen, F., Kuchen, S., Germain, R.N., A systems analysis identifies a feed-forward inflammatory circuit leading to lethal influenza infection (2013) Cell, 154 (1), pp. 197-212. , https://doi.org/10.1016/j.cell.2013.06.013; Hogner, K., Wolff, T., Pleschka, S., Plog, S., Gruber, A.D., Kalinke, U., Walmrath, H.D., Herold, S., Macrophage-expressed IFN-beta contributes to apoptotic alveolar epithelial cell injury in severe influenza virus pneumonia (2013) Plos Pathog, 9 (2). , https://doi.org/10.1371/journal.ppat.1003188; Fujikura, D., Chiba, S., Muramatsu, D., Kazumata, M., Nakayama, Y., Kawai, T., Akira, S., Miyazaki, T., Type-I interferon is critical for FasL expression on lung cells to determine the severity of influenza (2013) Plos One, 8 (2). , https://doi.org/10.1371/journal.pone.0055321; Teijaro, J.R., Walsh, K.B., Cahalan, S., Fremgen, D.M., Roberts, E., Scott, F., Martinborough, E., Rosen, H., Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection (2011) Cell, 146 (6), pp. 980-991. , https://doi.org/10.1016/j.cell.2011.08.015","Channappanavar, R.; Institute for the Study of Host-Pathogen Systems, University of Tennessee Health Science CenterUnited States; email: rchanna1@uthsc.edu",,Humana Press Inc.,10643745,,,31883097,English,Methods Mol. Biol.,Book Chapter,Final,Open Access,Scopus,2-s2.0-85077334544,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Kemp V., Laconi A., Cocciolo G., Berends A.J., Breit T.M., Verheije M.H.",57214800009;55960093400;57193340457;57194493485;35241768000;7801561319;,miRNA repertoire and host immune factor regulation upon avian coronavirus infection in eggs,2020,Archives of Virology,,,,,,,,10.1007/s00705-020-04527-4,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079193377&doi=10.1007%2fs00705-020-04527-4&partnerID=40&md5=ed62f8278a792f80205ed615ba3e53fb,"Faculty of Veterinary Medicine, Department Biomolecular Health Sciences, Division Pathology, Utrecht University, Utrecht, Netherlands; Department of Veterinary Medicine, University of Bari, Valenzano, Italy; RNA Biology and Applied Bioinformatics Research Group, Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Amsterdam, Netherlands; Department of Comparative Biomedicine and Food Science, University of Padua, Legnaro, Italy","Kemp, V., Faculty of Veterinary Medicine, Department Biomolecular Health Sciences, Division Pathology, Utrecht University, Utrecht, Netherlands; Laconi, A., Faculty of Veterinary Medicine, Department Biomolecular Health Sciences, Division Pathology, Utrecht University, Utrecht, Netherlands, Department of Comparative Biomedicine and Food Science, University of Padua, Legnaro, Italy; Cocciolo, G., Department of Veterinary Medicine, University of Bari, Valenzano, Italy; Berends, A.J., Faculty of Veterinary Medicine, Department Biomolecular Health Sciences, Division Pathology, Utrecht University, Utrecht, Netherlands; Breit, T.M., RNA Biology and Applied Bioinformatics Research Group, Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Amsterdam, Netherlands; Verheije, M.H., Faculty of Veterinary Medicine, Department Biomolecular Health Sciences, Division Pathology, Utrecht University, Utrecht, Netherlands","Avian infectious bronchitis virus (IBV) is a coronavirus with great economic impact on the poultry industry, causing an acute and highly contagious disease in chickens that primarily affects the respiratory and reproductive systems. The cellular regulation of IBV pathogenesis and the host immune responses involved remain to be fully elucidated. MicroRNAs (miRNAs) have emerged as a class of crucial regulators of numerous cellular processes, including responses to viral infections. Here, we employed a high-throughput sequencing approach to analyze the miRNA composition of the spleen and the lungs of chicken embryos upon IBV infection. Compared to healthy chicken embryos, 13 and six miRNAs were upregulated in the spleen and the lungs, respectively, all predicted to influence viral transcription, cytokine production, and lymphocyte functioning. Subsequent downregulation of NFATC3, NFAT5, SPPL3, and TGFB2 genes in particular was observed only in the spleen, demonstrating the biological functionality of the miRNAs in this lymphoid organ. This is the first study that describes the modulation of miRNAs and the related host immune factors by IBV in chicken embryos. Our data provide novel insight into complex virus-host interactions and specifically highlight components that could affect the host’s immune response to IBV infection. © 2020, The Author(s).",,,"Cavanagh, D., Coronavirus avian infectious bronchitis virus (2007) Vet Res, 38 (2), pp. 281-297; Chhabra, R., Kuchipudi, S.V., Chantrey, J., Ganapathy, K., Pathogenicity and tissue tropism of infectious bronchitis virus is associated with elevated apoptosis and innate immune responses (2016) Virology, 488, pp. 232-241; Liang, J.Q., Fang, S., Yuan, Q., Huang, M., Chen, R.A., Fung, T.S., Liu, D.X., N-Linked glycosylation of the membrane protein ectodomain regulates infectious bronchitis virus-induced ER stress response, apoptosis and pathogenesis (2019) Virology, 531, pp. 48-56; Ma, X., Zhao, X., Zhang, Z., Guo, J., Guan, L., Li, J., Mi, M., Tong, D., Differentially expressed non-coding RNAs induced by transmissible gastroenteritis virus potentially regulate inflammation and NF-kappaB pathway in porcine intestinal epithelial cell line (2018) BMC Genom, 19 (1), p. 747; Li, Z., Luo, Q., Xu, H., Zheng, M., Abdalla, B.A., Feng, M., Cai, B., Zhang, X., MiR-34b-5p suppresses melanoma differentiation-associated gene 5 (MDA5) signaling pathway to promote avian leukosis virus subgroup J (ALV-J)-infected cells proliferaction and ALV-J replication (2017) Front Cell Infect Microbiol, 7, p. 17; Lv, X., Zhao, K., Lan, Y., Li, Z., Ding, N., Su, J., Lu, H., He, W., miR-21a-5p contributes to porcine hemagglutinating encephalomyelitis virus proliferation via targeting CASK-interactive protein1 in vivo and vitro (2017) Front Microbiol, 8, p. 304; Dickey, L.L., Worne, C.L., Glover, J.L., Lane, T.E., O’Connell, R.M., MicroRNA-155 enhances T cell trafficking and antiviral effector function in a model of coronavirus-induced neurologic disease (2016) J Neuroinflammation, 13 (1), p. 240; Peng, X., Gralinski, L., Ferris, M.T., Frieman, M.B., Thomas, M.J., Proll, S., Korth, M.J., Katze, M.G., Integrative deep sequencing of the mouse lung transcriptome reveals differential expression of diverse classes of small RNAs in response to respiratory virus infection (2011) MBio; Mallick, B., Ghosh, Z., Chakrabarti, J., MicroRNome analysis unravels the molecular basis of SARS infection in bronchoalveolar stem cells (2009) PLoS One, 4 (11); Yang, X., Gao, W., Liu, H., Li, J., Chen, D., Yuan, F., Zhang, Z., Wang, H., MicroRNA transcriptome analysis in chicken kidneys in response to differing virulent infectious bronchitis virus infections (2017) Arch Virol, 162 (11), pp. 3397-3405; Reed, L.J., Muench, H., A simple method of estimating fifty per cent endpoints12 (1938) Am J Epidemiol, 27 (3), pp. 493-497; Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution (2004) Nature, 432 (7018), pp. 695-716; Griffiths-Jones, S., Saini, H.K., van Dongen, S., Enright, A.J., miRBase: tools for microRNA genomics (2008) Nucleic Acids Res, 36 (Database issue), pp. D154-D158; Menachery, V.D., Eisfeld, A.J., Schafer, A., Josset, L., Sims, A.C., Proll, S., Fan, S., Baric, R.S., Pathogenic influenza viruses and coronaviruses utilize similar and contrasting approaches to control interferon-stimulated gene responses (2014) MBio, 5 (3), pp. e01174-e02014; Amaral, A.J., Andrade, J., Foxall, R.B., Matoso, P., Matos, A.M., Soares, R.S., Rocha, C., Sousa, A.E., miRNA profiling of human naive CD4 T cells links miR-34c-5p to cell activation and HIV replication (2017) EMBO J, 36 (3), pp. 346-360; Smith, J.L., Jeng, S., McWeeney, S.K., Hirsch, A.J., A microRNA screen identifies the wnt signaling pathway as a regulator of the interferon response during flavivirus infection (2017) J Virol; Wang, Y., Brahmakshatriya, V., Zhu, H., Lupiani, B., Reddy, S.M., Yoon, B.J., Gunaratne, P.H., Zhou, H., Identification of differentially expressed miRNAs in chicken lung and trachea with avian influenza virus infection by a deep sequencing approach (2009) BMC Genom, 10, p. 512; Bakre, A., Andersen, L.E., Meliopoulos, V., Coleman, K., Yan, X., Brooks, P., Crabtree, J., Tripp, R.A., Identification of host kinase genes required for influenza virus replication and the regulatory role of microRNAs (2013) PLoS One, 8 (6); Peng, F., He, J., Loo, J.F., Yao, J., Shi, L., Liu, C., Zhao, C., Gu, D., Identification of microRNAs in throat swab as the biomarkers for diagnosis of influenza (2016) Int J Med Sci, 13 (1), pp. 77-84; Dinh, H., Hong, Y.H., Lillehoj, H.S., Modulation of microRNAs in two genetically disparate chicken lines showing different necrotic enteritis disease susceptibility (2014) Vet Immunol Immunopathol, 159 (1-2), pp. 74-82; Kamada, K., Shoji, I., Deng, L., Aoki, C., Ratnoglik, S.L., Wakita, T., Hotta, H., Generation of a recombinant reporter hepatitis C virus useful for the analyses of virus entry, intra-cellular replication and virion production (2012) Microbes Infect, 14 (1), pp. 69-78; Chen, Q., Tong, C., Ma, S., Zhou, L., Zhao, L., Zhao, X., Involvement of microRNAs in probiotics-induced reduction of the cecal inflammation by salmonella typhimurium (2017) Front Immunol, 8, p. 704; Jia, Y.Q., Wang, X.L., Wang, X.W., Yan, C.Q., Lv, C.J., Li, X.Q., Chu, Z.L., Yang, Z.Q., Common microRNA(-)mRNA interactions in different newcastle disease virus-infected chicken embryonic visceral tissues (2018) Int J Mol Sci; Gutkoska, J., LaRocco, M., Ramirez-Medina, E., de Los, S.T., Lawrence, P., Host microRNA-203a is antagonistic to the progression of foot-and-mouth disease virus infection (2017) Virology, 504, pp. 52-62; Wu, A., Chen, H., Xu, C., Zhou, J., Chen, S., Shi, Y., Xu, J., Zhang, J., miR-203a is involved in HBx-induced inflammation by targeting Rap1a (2016) Exp Cell Res, 349 (1), pp. 191-197; Liu, D., Wu, J., Liu, M., Yin, H., He, J., Zhang, B., Downregulation of miRNA-30c and miR-203a is associated with hepatitis C virus core protein-induced epithelial-mesenchymal transition in normal hepatocytes and hepatocellular carcinoma cells (2015) Biochem Biophys Res Commun, 464 (4), pp. 1215-1221; Inchley, C.S., Sonerud, T., Fjaerli, H.O., Nakstad, B., Nasal mucosal microRNA expression in children with respiratory syncytial virus infection (2015) BMC Infect Dis, 15, p. 150; Shi, T., Hua, Q., Ma, Z., Lv, Q., Downregulation of miR-200a-3p induced by hepatitis B Virus X (HBx) Protein promotes cell proliferation and invasion in HBV-infection-associated hepatocarcinoma (2017) Pathol Res Pract, 213 (12), pp. 1464-1469; Ellis-Connell, A.L., Iempridee, T., Xu, I., Mertz, J.E., Cellular microRNAs 200b and 429 regulate the Epstein–Barr virus switch between latency and lytic replication (2010) J Virol, 84 (19), pp. 10329-10343; Wu, G., Qi, Y., Liu, X., Yang, N., Xu, G., Liu, L., Li, X., Cecal microRNAome response to Salmonella enterica serovar Enteritidis infection in White Leghorn Layer (2017) BMC Genom, 18 (1), p. 77; Castillo, J.A., Castrillon, J.C., Diosa-Toro, M., Betancur, J.G., St Laurent, G., 3rd, Smit, J.M., Urcuqui-Inchima, S., Complex interaction between dengue virus replication and expression of miRNA-133a (2016) BMC Infect Dis, 16, p. 29; Zheng, Y., Fu, X., Wang, L., Zhang, W., Zhou, P., Zhang, X., Zeng, W., Li, S., Comparative analysis of MicroRNA expression in dog lungs infected with the H3N2 and H5N1 canine influenza viruses (2018) Microb Pathog, 121, pp. 252-261; Wang, Y., Brahmakshatriya, V., Lupiani, B., Reddy, S.M., Soibam, B., Benham, A.L., Gunaratne, P., Zhou, H., Integrated analysis of microRNA expression and mRNA transcriptome in lungs of avian influenza virus infected broilers (2012) BMC Genomics, 13, p. 278; Skovgaard, K., Cirera, S., Vasby, D., Podolska, A., Breum, S.O., Durrwald, R., Schlegel, M., Heegaard, P.M., Expression of innate immune genes, proteins and microRNAs in lung tissue of pigs infected experimentally with influenza virus (H1N2) (2013) Innate Immun, 19 (5), pp. 531-544","Verheije, M.H.; Faculty of Veterinary Medicine, Department Biomolecular Health Sciences, Division Pathology, Utrecht UniversityNetherlands; email: m.h.verheije@uu.nl",,Springer,3048608,,ARVID,,English,Arch. Virol.,Article,Article in Press,Open Access,Scopus,2-s2.0-85079193377,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wang Y., Li X., Liu W., Gan M., Zhang L., Wang J., Zhang Z., Zhu A., Li F., Sun J., Zhang G., Zhuang Z., Luo J., Chen D., Qiu S., Zhang L., Xu D., Mok C.K.P., Zhang F., Zhao J., Zhou R., Zhao J.",57215437515;57200135132;42861832700;57214361417;57214361148;57214361692;57214361950;57203143757;57214361905;57203139620;57214361112;57214361305;55482642500;55561402600;56158095400;57213178612;57191609898;36159732100;57189252300;57201372305;55359175300;8584763700;,"Discovery of a subgenotype of human coronavirus NL63 associated with severe lower respiratory tract infection in China, 2018",2020,Emerging Microbes and Infections,9,1,,246,255,,1,10.1080/22221751.2020.1717999,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078691103&doi=10.1080%2f22221751.2020.1717999&partnerID=40&md5=abef939491b4586de825d20cbebd11e6,"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Institute of Infectious disease, Guangzhou Eighth People's Hospital of Guangzhou Medical University, Guangzhou, China; The HKU–Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong","Wang, Y., State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Li, X., State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Liu, W., State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Gan, M., State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Zhang, L., Institute of Infectious disease, Guangzhou Eighth People's Hospital of Guangzhou Medical University, Guangzhou, China; Wang, J., State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Zhang, Z., State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Zhu, A., State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Li, F., State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Sun, J., State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Zhang, G., State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Zhuang, Z., State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Luo, J., State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Chen, D., State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Qiu, S., State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Zhang, L., State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Xu, D., State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Mok, C.K.P., State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China, The HKU–Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong; Zhang, F., Institute of Infectious disease, Guangzhou Eighth People's Hospital of Guangzhou Medical University, Guangzhou, China; Zhao, J., State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Zhou, R., State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Zhao, J., State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China, Institute of Infectious disease, Guangzhou Eighth People's Hospital of Guangzhou Medical University, Guangzhou, China","Human coronavirus NL63 (HCoV-NL63) is primarily associated with common cold in children, elderly and immunocompromised individuals. Outbreaks caused by HCoV-NL63 are rare. Here we report a cluster of HCoV-NL63 cases with severe lower respiratory tract infection that arose in Guangzhou, China, in 2018. Twenty-three hospitalized children were confirmed to be HCoV-NL63 positive, and most of whom were hospitalized with severe pneumonia or acute bronchitis. Whole genomes of HCoV-NL63 were obtained using next-generation sequencing. Phylogenetic and single amino acid polymorphism analyses showed that this outbreak was associated with two subgenotypes (C3 and B) of HCoV-NL63. Half of patients were identified to be related to a new subgenotype C3. One unique amino acid mutation at I507 L in spike protein receptor binding domain (RBD) was detected, which segregated this subgenotype C3 from other known subgenotypes. Pseudotyped virus bearing the I507 L mutation in RBD showed enhanced entry into host cells as compared to the prototype virus. This study proved that HCoV-NL63 was undergoing continuous mutation and has the potential to cause severe lower respiratory disease in humans. © 2020, © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd.",human coronavirus NL63; new subgenotype; phylogenetic analysis; pneumonia; viral entry; whole-genome sequencing,"Article; bronchitis; child; China; clinical article; common cold; comparative study; controlled study; coughing; disease severity; dyspnea; female; fever; genetic variability; high throughput sequencing; human; Human coronavirus NL63; lower respiratory tract infection; male; nasopharyngeal aspiration; pathogenesis; pediatric patient; phylogeny; pneumonia; preschool child; priority journal; real time polymerase chain reaction; SARS coronavirus; upper respiratory tract infection; Vesiculovirus; virus entry; virus load; wheezing; whole genome sequencing; Coronavirus infection; genetics; genotype; Human coronavirus NL63; infant; isolation and purification; respiratory tract infection; virology; Child, Preschool; China; Coronavirus Infections; Coronavirus NL63, Human; Genotype; Humans; Infant; Phylogeny; Respiratory Tract Infections","Almeida, J.D., Tyrrell, D., The morphology of three previously uncharacterized human respiratory viruses that grow in organ culture (1967) J Gen Virol, 1 (2), pp. 175-178; Kapikian, A.Z., James Jr, H.D., Kelly, S.J., Isolation from man of “avian infectious bronchitis virus-like” viruses (coronaviruses) similar to 229E virus, with some epidemiological observations (1969) J Infect Dis, 119 (3), pp. 282-290; Peiris, J., Guan, Y., Yuen, K., Severe acute respiratory syndrome (2004) Nat Med, 10 (12s), p. S88; van der Hoek, L., Pyrc, K., Jebbink, M.F., Identification of a new human coronavirus (2004) Nat Med, 10 (4), p. 368; Woo, P.C., Lau, S.K., Chu, C.-M., Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia (2005) J Virol, 79 (2), pp. 884-895; Zaki, A.M., Van Boheemen, S., Bestebroer, T.M., Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia (2012) N Engl J Med, 367 (19), pp. 1814-1820; Peiris, J.S., Yuen, K.Y., Osterhaus, A.D., The severe acute respiratory syndrome (2003) N Engl J Med, 349 (25), pp. 2431-2441; Woo, P.C., Lau, S.K., Yip, C.C., More and more coronaviruses: human coronavirus HKU1 (2009) Viruses, 1 (1), pp. 57-71. , Jun; Fielding, B.C., Human coronavirus NL63: a clinically important virus? (2011) Future Microbiol, 6 (2), pp. 153-159. , Feb; Abdul-Rasool, S., Fielding, B.C., Understanding human coronavirus HCoV-NL63 (2010) Open Virol J, 4, pp. 76-84. , May 25; Konca, C., Korukluoglu, G., Tekin, M., The first infant death associated with human coronavirus NL63 infection (2017) Pediatr Infect Dis J, 36 (2), pp. 231-233; Hofmann, H., Pyrc, K., van der Hoek, L., Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry (2005) Proc Natl Acad Sci USA, 102 (22), pp. 7988-7993. , May 31; Zeng, Z.-Q., Chen, D.-H., Tan, W.-P., Epidemiology and clinical characteristics of human coronaviruses OC43, 229E, NL63, and HKU1: a study of hospitalized children with acute respiratory tract infection in Guangzhou, China (2018) Eur J Clin Microbiol Infect Dis, 37 (2), pp. 363-369; Pyrc, K., Dijkman, R., Deng, L., Mosaic structure of human coronavirus NL63, one thousand years of evolution (2006) J Mol Biol, 364 (5), pp. 964-973; Cui, L.-J., Zhang, C., Zhang, T., Human coronaviruses HCoV-NL63 and HCoV-HKU1 in hospitalized children with acute respiratory infections in Beijing, China (2011) Adv Virol, 2011, pp. 129-134; Wang, Y., Zhu, N., Li, Y., Metagenomic analysis of viral genetic diversity in respiratory samples from children with severe acute respiratory infection in China (2016) Clin Microbiol Infect, 22 (5), p. 458; Guindon, S., Dufayard, J.-F., Lefort, V., New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0 (2010) Syst Biol, 59 (3), pp. 307-321; Katoh, K., Rozewicki, J., Yamada, K.D., MAFFT online service: multiple sequence alignment, interactive sequence choice and visualization (2019) Brief. Bioinformatics, 20 (4), pp. 1160-1166; Kumar, S., Stecher, G., Tamura, K., MEGA7: molecular evolutionary genetics analysis version 7.0 for bigger datasets (2016) Mol Biol Evol, 33 (7), pp. 1870-1874; Lole, K.S., Bollinger, R.C., Paranjape, R.S., Full-length human immunodeficiency virus type 1 genomes from subtype C-infected seroconverters in India, with evidence of intersubtype recombination (1999) J Virol, 73 (1), pp. 152-160; Peng, G., Sun, D., Rajashankar, K.R., Crystal structure of mouse coronavirus receptor-binding domain complexed with its murine receptor (2011) Proc Natl Acad Sci USA, 108 (26), pp. 10696-10701; Whitt, M.A., Generation of VSV pseudotypes using recombinant ΔG-VSV for studies on virus entry, identification of entry inhibitors, and immune responses to vaccines (2010) J Virol Methods, 169 (2), pp. 365-374; Dominguez, S.R., Sims, G.E., Wentworth, D.E., Genomic analysis of 16 Colorado human NL63 coronaviruses identifies a new genotype, high sequence diversity in the N-terminal domain of the spike gene and evidence of recombination (2012) J Gen Virol, 93 (11), pp. 2387-2398; Wu, K., Li, W., Peng, G., Crystal structure of NL63 respiratory coronavirus receptor-binding domain complexed with its human receptor (2009) Proc Natl Acad Sci USA, 106 (47), pp. 19970-19974; Lin, H.-X., Feng, Y., Tu, X., Characterization of the spike protein of human coronavirus NL63 in receptor binding and pseudotype virus entry (2011) Virus Res, 160 (1-2), pp. 283-293; Milewska, A., Nowak, P., Owczarek, K., Entry of human coronavirus NL63 into the cell[J] (2018) J Virol, 92 (3). , e01933–17; Kiyuka, P.K., Agoti, C.N., Munywoki, P.K., Human coronavirus NL63 molecular epidemiology and evolutionary patterns in rural coastal Kenya (2018) J Infect Dis, 217 (11), pp. 1728-1739; Hand, J., Rose, E.B., Salinas, A., Severe respiratory illness outbreak associated with human coronavirus NL63 in a long-term care facility (2018) Emerg Infect Dis, 24 (10), pp. 1964-1966. , Oct; Geng, H., Cui, L., Xie, Z., Characterization and complete genome sequence of human coronavirus NL63 isolated in China (2012) J Virol, 86 (17), pp. 9546-9547. , Sep; Chiu, S.S., Hung Chan, K., Wing Chu, K., Human coronavirus NL63 infection and other coronavirus infections in children hospitalized with acute respiratory disease in Hong Kong, China (2005) Clin Infect Dis, 40 (12), pp. 1721-1729; Lu, R., Yu, X., Wang, W., Characterization of human coronavirus etiology in Chinese adults with acute upper respiratory tract infection by real-time RT-PCR assays (2012) PLoS one, 7 (6); Azhar, E.I., El-Kafrawy, S.A., Farraj, S.A., Evidence for camel-to-human transmission of MERS coronavirus (2014) N Engl J Med, 370 (26), pp. 2499-2505; Feng, Y., Gao, G.F., Towards our understanding of SARS-CoV, an emerging and devastating but quickly conquered virus (2007) Comp Immunol Microbiol Infect Dis, 30 (5-6), pp. 309-327","Zhao, J.; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University; Institute of Infectious disease, Guangzhou Eighth People's Hospital of Guangzhou Medical UniversityChina; email: zhaojincun@gird.cn",,Taylor and Francis Ltd.,22221751,,,31996093,English,Emerg. Microbes Infect.,Article,Final,Open Access,Scopus,2-s2.0-85078691103,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Algaissi A., Agrawal A.S., Hashem A.M., Tseng C.-T.K.",57046024300;57204367081;57200589744;7402541658;,Quantification of the middle east respiratory syndrome-coronavirus rna in tissues by quantitative real-time RT-PCR,2020,Methods in Molecular Biology,2099,,,99,106,,,10.1007/978-1-0716-0211-9_8,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077334771&doi=10.1007%2f978-1-0716-0211-9_8&partnerID=40&md5=ec20794216c2fa031db7af132539f315,"Departments of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, United States; Department of Medical Laboratories Technology, College of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia; Department of Medical Microbiology and Parasitology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia; Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia; Center for Biodefense and Emerging Infectious Disease, University of Texas Medical Branch, Galveston, TX, United States","Algaissi, A., Departments of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, United States, Department of Medical Laboratories Technology, College of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia; Agrawal, A.S., Departments of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, United States; Hashem, A.M., Department of Medical Microbiology and Parasitology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia, Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia; Tseng, C.-T.K., Departments of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, United States, Center for Biodefense and Emerging Infectious Disease, University of Texas Medical Branch, Galveston, TX, United States","Since the emergence of the Middle East respiratory syndrome-coronavirus (MERS-CoV) in 2012, more than 2280 confirmed human infections and 800 associated deaths had been reported to the World Health Organization. MERS-CoV is a single-stranded RNA virus that belongs to the Coronaviridae family. MERS-CoV infection leads to a variety of clinical outcomes in humans ranging from asymptomatic and mild infection to severe acute lung injury and multi-organ failure and death. To study the pathogenesis of MERS-CoV infection and development of medical countermeasures (MCMs) for MERS, a number of genetically modified mouse models have been developed, including various versions of transgenic mice expressing the human DPP4 viral receptor. Tracking and quantifying viral infection, among others, in permissive hosts is a key endpoint for studying MERS pathogenesis and evaluating the efficacy of selected MCMs developed for MERS. In addition to quantifying infectious progeny virus which requires high-containment biosafety level (BSL)-3 laboratory, here we outlined an established real-time quantitative RT-PCR (RT-qPCR)-based procedure to unequivocally quantify MERS-CoV-specific RNAs within the lungs of infected human DPP4 (hDPP4, transgenic (hDPP4 Tg) mice under a standard BSL-2 laboratory. © Springer Science+Business Media, LLC, part of Springer Nature 2020.",Animal models; MERS-CoV; RT-qPCR,,"Zaki, A.M., van Boheemen, S., Bestebroer, T.M., Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia (2012) N Engl J Med, 367, pp. 1814-1820. , https://doi.org/10.1056/NEJMoa1211721; Chan, J.F.W., Lau, S.K.P., To, K.K.W., Middle East respiratory syndrome coronavirus: Another zoonotic betacoronavirus causing SARS-like disease (2015) Clin Microbiol Rev, 28, pp. 465-522. , https://doi.org/10.1128/CMR.00102-14; Fehr, A.R., Perlman, S., Coronaviruses: An overview of their replication and pathogenesis (2015) Methods Mol Biol, 1282, pp. 1-23. , https://doi.org/10.1007/978-1-4939-2438-7_1; de Wit, E., van Doremalen, N., Falzarano, D., SARS and MERS: Recent insights into emerging coronaviruses (2016) Nat Rev Microbiol, 14, pp. 523-534. , https://doi.org/10.1038/nrmicro.2016.81; Coleman, C.M., Matthews, K.L., Goicochea, L., Wild-type and innate immune-deficient mice are not susceptible to the Middle East respiratory syndrome coronavirus (2014) J Gen Virol, 95, pp. 408-412. , https://doi.org/10.1099/vir.0.060640-0; Cockrell, A.S., Peck, K.M., Yount, B.L., Mouse Dipeptidyl peptidase 4 is not a functional receptor for Middle East respiratory syndrome coronavirus infection (2014) J Virol, 88, pp. 5195-5199. , https://doi.org/10.1128/JVI.03764-13; Agrawal, A.S., Garron, T., Tao, X., Generation of a transgenic mouse model of Middle East respiratory syndrome coronavirus infection and disease (2015) J Virol, 89, pp. 3659-3670. , https://doi.org/10.1128/JVI.03427-14; Tao, X., Garron, T., Agrawal, A.S., Characterization and demonstration of value of a lethal mouse model of Middle East respiratory syndrome coronavirus infection and disease (2015) J Virol, 90, pp. 57-67. , https://doi.org/10.1128/JVI.02009-15","Tseng, C.-T.K.; Center for Biodefense and Emerging Infectious Disease, University of Texas Medical BranchUnited States; email: sktseng@utmb.edu",,Humana Press Inc.,10643745,,,31883090,English,Methods Mol. Biol.,Book Chapter,Final,Open Access,Scopus,2-s2.0-85077334771,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhuang Q., Liu S., Zhang X., Jiang W., Wang K., Wang S., Peng C., Hou G., Li J., Yu X., Yuan L., Wang J., Li Y., Liu H., Chen J.",35726399700;34977101000;57215938227;12786873200;55501532300;55533670600;57212118818;35169518600;55171214600;57201478490;57214089597;57215938284;57215938029;15729279200;55717791800;,Surveillance and taxonomic analysis of the coronavirus dominant in pigeons in China,2020,Transboundary and Emerging Diseases,,,,,,,,10.1111/tbed.13541,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082414849&doi=10.1111%2ftbed.13541&partnerID=40&md5=52acdc5a63dba3e36e4b6f3ba6290357,"China Animal Health and Epidemiology Center, Qingdao, China; Zhaoqing University, Zhaoqing, China; College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, China","Zhuang, Q., China Animal Health and Epidemiology Center, Qingdao, China; Liu, S., China Animal Health and Epidemiology Center, Qingdao, China; Zhang, X., Zhaoqing University, Zhaoqing, China; Jiang, W., China Animal Health and Epidemiology Center, Qingdao, China; Wang, K., China Animal Health and Epidemiology Center, Qingdao, China; Wang, S., China Animal Health and Epidemiology Center, Qingdao, China; Peng, C., China Animal Health and Epidemiology Center, Qingdao, China; Hou, G., China Animal Health and Epidemiology Center, Qingdao, China; Li, J., China Animal Health and Epidemiology Center, Qingdao, China; Yu, X., China Animal Health and Epidemiology Center, Qingdao, China; Yuan, L., China Animal Health and Epidemiology Center, Qingdao, China; Wang, J., China Animal Health and Epidemiology Center, Qingdao, China; Li, Y., China Animal Health and Epidemiology Center, Qingdao, China; Liu, H., China Animal Health and Epidemiology Center, Qingdao, China; Chen, J., China Animal Health and Epidemiology Center, Qingdao, China, College of Veterinary Medicine, Qingdao Agricultural University, Qingdao, China","Coronaviruses (CoVs) are found in humans and a wide variety of wild and domestic animals, and of substantial impact on human and animal health. In poultry, the genetic diversity, evolution, distribution and taxonomy of CoVs dominant in birds other than chickens remain enigmatic. In our previous study, we proposed that the CoVs dominant (i.e. mainly circulating) in ducks (DdCoVs) should represent a novel species, which was different from the one represented by the CoVs dominant in chickens (CdCoVs). In this study, we conducted a large-scale surveillance of CoVs in chickens, ducks, geese, pigeons and other birds (quails, sparrows and partridges) using a conserved RT-PCR assay. The surveillance demonstrated that CdCoVs, DdCoVs and the CoVs dominant in pigeons (PdCoVs) belong to different lineages, and they are all prevalent in live poultry markets and the backyard flocks in some regions of China. We further sequenced seven Coronaviridae-wide conserved domains in their replicase polyprotein pp1ab of seven PdCoVs and found that the genetic distances in these domains between PdCoVs and DdCoVs or CdCoVs are large enough to separate PdCoVs into a novel species, which were different from the ones represented by DdCoVs or CdCoVs within the genus Gammacoronavirus, per the species demarcation criterion of International Committee on Taxonomy of Viruses. This report shed novel insight into the genetic diversity, distribution, evolution and taxonomy of avian CoVs. © 2020 Blackwell Verlag GmbH",coronavirus; genetic distance; lineage; pigeon; sequence; species; surveillance; taxonomy,,"Ashton, W.L., The risks and problems connected with the import and export of captive birds (1984) The British Veterinary Journal, 140, pp. 317-327. , https://doi.org/10.1016/0007-1935(84)90121-0; Chen, G.-Q., Zhuang, Q.-Y., Wang, K.-C., Liu, S., Shao, J.-Z., Jiang, W.-M., Chen, J.-M., Identification and survey of a novel avian coronavirus in ducks (2013) PLoS ONE, 8. , https://doi.org/10.1371/journal.pone.0072918; Cheng, V.C., Lau, S.K., Woo, P.C., Yuen, K.Y., Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection (2007) Clinical Microbiology Reviews, 20, pp. 660-694. , https://doi.org/10.1128/CMR.00023-07; Cook, J.K., Jackwood, M., Jones, R.C., The long view: 40 years of infectious bronchitis research (2012) Avian Pathology, 41, pp. 239-250. , https://doi.org/10.1080/03079457.2012.680432; Day, J.M., Gonder, E., Jennings, S., Rives, D., Robbins, K., Tilley, B., Wooming, B., Investigating turkey enteric coronavirus circulating in the Southeastern United States and Arkansas during 2012 and 2013 (2014) Avian Diseases, 58, pp. 313-317. , https://doi.org/10.1637/10674-092313-ResNote.1; de Groot, R.J., Baker, S.C., Baric, R., Enjuanes, L., Gorbalenya, A.E., Holmes, K.V., Coronaviridae (2012) Ninth report of the international committee on taxonomy of viruses, pp. 806-828. , A. A. Q. King, M. J. Adams, E. B. Carstens, E. J. 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Jordan, B.J., Hilt, D.A., Poulson, R., Stallknecht, D.E., Jackwood, M.W., Identification of avian coronavirus in wild aquatic birds of the central and eastern USA (2015) Journal of Wildlife Diseases, 51, pp. 218-221. , https://doi.org/10.7589/2014-03-070; Kumar, S., Stecher, G., Tamura, K., MEGA7: molecular evolutionary genetics analysis version 7.0 for bigger datasets (2016) Molecular Biology and Evolution, 33, pp. 1870-1874. , https://doi.org/10.1093/molbev/msw054; Lau, S.K.P., Wernery, R., Wong, E.Y.M., Joseph, S., Tsang, A.K.L., Patteril, N.A.G., Woo, P.C.Y., Polyphyletic origin of MERS coronaviruses and isolation of a novel clade A strain from dromedary camels in the United Arab Emirates (2016) Emerging Microbes & Infections, 5. , https://doi.org/10.1038/emi.2016.129; Lau, S.K.P., Wong, E.Y.M., Tsang, C.-C., Ahmed, S.S., Au-Yeung, R.K.H., Yuen, K.-Y., Woo, P.C.Y., Discovery and sequence analysis of four deltacoronaviruses from birds in the middle east reveal interspecies jumping with recombination as a potential mechanism for avian-to-avian and avian-to-mammalian transmission (2018) Journal of Virology, 92. , https://doi.org/10.1128/JVI.00265-18; Liu, S., Chen, J., Chen, J., Kong, X., Shao, Y., Han, Z., Liu, M., Isolation of avian infectious bronchitis coronavirus from domestic peafowl (Pavo cristatus) and teal (Anas) (2005) Journal of General Virology, 86, pp. 719-725. , https://doi.org/10.1099/vir.0.80546-0; Liu, S., Xu, Q., Han, Z., Liu, X., Li, H., Guo, H., Kong, X., Origin and characteristics of the recombinant novel avian infectious bronchitis coronavirus isolate ck/CH/LJL/111054 (2014) Infection, Genetics and Evolution, 23, pp. 189-195. , https://doi.org/10.1016/j.meegid.2014.02.015; Marra, M.A., Jones, S.J., Astell, C.R., Holt, R.A., Brooks-Wilson, A., Butterfield, Y.S., Pandoh, P.K., The Genome sequence of the SARS-associated coronavirus (2003) Science, 300, pp. 1399-1404. , https://doi.org/10.1126/science.1085953; Mihindukulasuriya, K.A., Wu, G., St Leger, J., Nordhausen, R.W., Wang, D., Identification of a novel coronavirus from a beluga whale by using a panviral microarray (2008) Journal of Virology, 82, pp. 5084-5088. , https://doi.org/10.1128/JVI.02722-07; Moreno, A., Franzo, G., Massi, P., Tosi, G., Blanco, A., Antilles, N., Cecchinato, M., A novel variant of the infectious bronchitis virus resulting from recombination events in Italy and Spain (2017) Avian Pathology: Journal of the WVPA, 46, pp. 28-35. , https://doi.org/10.1080/03079457.2016.1200011; Peiris, J., Lai, S.T., Poon, L., Guan, Y., Yam, L., Lim, W., Yuen, K.Y., Coronavirus as a possible cause of severe acute respiratory syndrome (2003) Lancet, 361, pp. 1319-1325. , https://doi.org/10.1016/s0140-6736(03)13077-2; Rota, P.A., Oberste, M.S., Monroe, S.S., Nix, W.A., Campagnoli, R., Icenogle, J.P., Burns, C., Characterization of a novel coronavirus associated with severe acute respiratory syndrome (2003) Science, 300, pp. 1394-1399. , https://doi.org/10.1126/science.1085952; Snijder, E.J., Bredenbeek, P.J., Dobbe, J.C., Thiel, V., Ziebuhr, J., Poon, L.L.M., Gorbalenya, A.E., Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineage (2003) Journal of Molecular Biology, 331, pp. 991-1004. , https://doi.org/10.1016/s0022-2836(03)00865-9; 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Woo, P.C.Y., Lau, S.K.P., Lam, C.S.F., Tsang, A.K.L., Hui, S.-W., Fan, R.Y.Y., Yuen, K.-Y., Discovery of a novel bottlenose dolphin coronavirus reveals a distinct species of marine mammal coronavirus in Gammacoronavirus (2014) Journal of Virology, 88, pp. 1318-1331. , https://doi.org/10.1128/JVI.02351-13; Woo, P.C.Y., Lau, S.K.P., Tsoi, H.-W., Chan, K.-H., Wong, B.H.L., Che, X.-Y., Yuen, K.-Y., Relative rates of non-pneumonic SARS coronavirus infection and SARS coronavirus pneumonia (2004) Lancet, 363, pp. 841-845. , https://doi.org/10.1016/S0140-6736(04)15729-2; Woo, P.C., Lau, S.K., Yip, C.C., Huang, Y., Tsoi, H.W., Chan, K.H., Yuen, K.Y., Comparative analysis of 22 coronavirus HKU1 genomes reveals a novel genotype and evidence of natural recombination in coronavirus HKU1 (2006) Journal of Virology, 80, pp. 7136-7145. , https://doi.org/10.1128/JVI.00509-06; (2020) Novel Coronavirus (2019-nCoV) situation reports, , https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports/, March 4)., Retrieved from; Zhuang, Q.-Y., Wang, K.-C., Liu, S., Hou, G.-Y., Jiang, W.-M., Wang, S.-C., Chen, J.-M., Genomic analysis and surveillance of the coronavirus dominant in ducks in China (2015) PLoS ONE, 10. , https://doi.org/10.1371/journal.pone.0129256","Chen, J.; China Animal Health and Epidemiology CenterChina; email: chenjiming@cahec.cn",,Blackwell Publishing Ltd,18651674,,,32163661,English,Transboundary Emer. Dis.,Article,Article in Press,Open Access,Scopus,2-s2.0-85082414849,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Nooh H.Z., Alshammary R.H., Alenezy J.M., Alrowaili N.H., Alsharari A.J., Alenzi N.M., Sabaa H.E.",56685701600;57215024400;57215020445;57215024710;57215024120;57215022264;57215022108;,"Public awareness of coronavirus in Al-Jouf region, Saudi Arabia",2020,Journal of Public Health (Germany),,,,,,,,10.1007/s10389-020-01209-y,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079698954&doi=10.1007%2fs10389-020-01209-y&partnerID=40&md5=2529bc3b8af4cca8aef0770b97bc48b1,"Faculty of Medicine, Jouf University, Sakaka, Saudi Arabia","Nooh, H.Z., Faculty of Medicine, Jouf University, Sakaka, Saudi Arabia; Alshammary, R.H., Faculty of Medicine, Jouf University, Sakaka, Saudi Arabia; Alenezy, J.M., Faculty of Medicine, Jouf University, Sakaka, Saudi Arabia; Alrowaili, N.H., Faculty of Medicine, Jouf University, Sakaka, Saudi Arabia; Alsharari, A.J., Faculty of Medicine, Jouf University, Sakaka, Saudi Arabia; Alenzi, N.M., Faculty of Medicine, Jouf University, Sakaka, Saudi Arabia; Sabaa, H.E., Faculty of Medicine, Jouf University, Sakaka, Saudi Arabia","Aim: Since 2012 and to date, outbreak/new cases of Middle East respiratory syndrome-related coronavirus (MERS-CoV) were always reported in Saudi Arabia. Al-Jouf region is considered as one of the most vulnerable areas to the disease outbreak. This research aimed to assess (to the best of our knowledge), for the first time, the current level of awareness towards MERS-CoV among the Al-Jouf region population through a well-designed multistage questionnaire. Subjects and methods: A cross-sectional study of 384 participants recruited from various places in Al-Jouf government was conducted through a valid and reliable questionnaire including sociodemographic and MERS-CoV knowledge data. Results: The majority of the participants showed generally moderate knowledge about MERS-CoV. Age, education, and occupation were the only significant predictors of the level of low awareness concern. Also, the public awareness about the nature, communicability, and lethal effect of the disease was good overall; however, knowledge about incubation period, clinical picture, and epidemiology of the disease needs more governmental concern. The Ministry of Health was the main source of information. Conclusion: Empowering public information regarding the incubation period and epidemiology of the disease is needed. Frequent communication between healthcare providers and both school students and non-educated individuals is recommended to help the Saudi government in controlling the disease outbreak. © 2020, Springer-Verlag GmbH Germany, part of Springer Nature.",Awareness; Camels; Coronavirus; Jouf; Population,,"Aguanno, R., ElIdrissi, A., Elkholy, A.A., MERS: Progress on the global response, remaining challenges and the way forward (2018) Antiviral Res, 159, pp. 35-44; Al-Abdullah, N., Kaki, R., Almutairi, O., Assessment of the awareness of Middle East respiratory syndrome-coronavirus infection in Saudi Arabia: a cross-sectional survey (2016) Internet J Infect Dis, 15 (1), pp. 1-8; Al-Mohrej, A., Agha, S., Are Saudi medical students aware of Middle East respiratory syndrome coronavirus during an outbreak? (2017) J Infect Public Health, 10 (4), pp. 388-395; Almutairi, K.M., Al Helih, E.M., Moussa, M., Awareness, attitudes, and practices related to coronavirus pandemic among public in Saudi Arabia (2015) Fam Community Health, 38 (4), pp. 332-340; Al-Osail, A.M., Al-Wazzah, M.J., The history and epidemiology of Middle East respiratory syndrome corona virus (2017) Multidiscip Respir Med, 12 (1), p. 20; Alqahtani, S.H., Aldawsari, M.N., The attitudes and degree of awareness about MERS-CoV among Saudis of different ages (2015) Clin Res Trials, 1 (3), pp. 55-57; Alsahafi, A.J., Cheng, A.C., Knowledge, attitudes and behaviours of healthcare workers in the kingdom of Saudi Arabia to MERS coronavirus and other emerging infectious diseases (2016) Int J Environ Res Public Health, 13 (12), p. E1214; Andualem, Y., Sisay, F., Yimer, A., Fanta, S., Public health risk and transmission route of Middle East respiratory syndrome (MERS): MERS coronavirus in dromedary camel (2017) J Vet Med Animal Health, 9 (3), pp. 39-46; Arabi, Y.M., Alothman, A., Balkhy, H.H., Treatment of Middle East Respiratory Syndrome with a combination of lopinavir-ritonavir and interferon-β1b (MIRACLE trial): study protocol for a randomized controlled trial (2018) Trials, 19 (1), p. 81; Assiri, A., McGeer, A., Perl, T.M., Hospital outbreak of Middle East respiratory syndrome coronavirus (2013) N Engl J Med, 369 (5), pp. 407-416. , COI: 1:CAS:528:DC%2BC3sXht1GmsrrL; 2,000-year-old camel sculpture discovered in Saudi desert. Ministry of Media, Saudi Arabia, , https://cic.org.sa/2018/02/2000-year-old-camel-sculpture-discovered-in-saudi-desert, Available online at, Accessed 12 Jul 2019; Elbur, A., Alharthi, A., Aljuaid, A., Hasan, N., Knowledge of Middle East respiratory syndrome coronavirus (MERS-CoV) and its management: a survey among Saudi people in Taif; Kingdom of Saudi Arabia (2016) IOSR J Pharm, 6 (8), pp. 33-39; (2010) Ar-aljouf population by gender, governorate, nationality, , https://www.stats.gov.sa, Web page database at, Accessed 15 Aug 2019; Evidence of person-to-person transmission within a family cluster of novel coronavirus infections, United Kingdom, February 2013 (2013) Euro Surveill, 18 (11), p. 20427; Joshi, R.M., Middle East respiratory syndrome coronavirus (MERS-CoV): perceptions, predictions, preventions and the pilgrimage (2013) Clin Microbiol, 2 (6), p. 1000e113; Khan, M.U., Shah, S., Ahmad, A., Fatokun, O., Knowledge and attitude of healthcare workers about Middle East Respiratory Syndrome in multispecialty hospitals of Qassim, Saudi Arabia (2014) BMC Public Health, 14 (1), p. 1281; Kharma, M.Y., Alalwani, M.S., Amer, M.F., Tarakji, B., Aws, G., Assessment of the awareness level of dental students toward Middle East Respiratory Syndrome-coronavirus (2015) J Int Soc Prev Community Dent, 5 (3), pp. 163-169; Lin, Q., Chiu, A.P., Zhao, S., He, D., Modeling the spread of Middle East respiratory syndrome coronavirus in Saudi Arabia (2018) Stat Methods Med Res, 27 (7), pp. 1968-1978; Memish, Z.A., Assiri, A., Alhakeem, R., Middle East respiratory syndrome corona virus, MERS-CoV. Conclusions from the 2nd Scientific Advisory Board Meeting of the WHO Collaborating Center for Mass Gathering Medicine, Riyadh (2014) Int J Infect Dis, 24, pp. 51-53; Seto, W., Conly, J.M., Pessoa-Silva, C.L., Malik, M., Eremin, S., Infection prevention and control measures for acute respiratory infections in healthcare settings: an update/Prevention des infections et mesures de lutte contre les infections respiratoires aiguës en milieu de soins: le point sur la situation (2013) East Mediterr Health J, 19, pp. S39-S47; (2014) Middle East Respiratory Syndrome Coronavirus (MERS-CoV)—update, , http://www.who.int/csr/don/2014_04_14_mers/en/index.html, Available online at, Accessed 17 Apr 2019; (2019) Middle East Respiratory Syndrome Coronavirus (MERS-CoV)—The Kingdom of Saudi Arabia, , https://www.who.int/csr/don/26-august-2019-mers-saudi-arabia/en/, Available online at, Accessed 15 Sep 2019","Nooh, H.Z.; Faculty of Medicine, Jouf UniversitySaudi Arabia; email: hznooh@ju.edu.sa",,Springer,21981833,,JPHHA,,English,J. Public Health,Article,Article in Press,Open Access,Scopus,2-s2.0-85079698954,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Kleine-Weber H., Schroeder S., Krüger N., Prokscha A., Naim H.Y., Müller M.A., Drosten C., Pöhlmann S., Hoffmann M.",57204592347;57196021608;55934578000;57214102210;35303364900;24068857400;7003813990;57210095234;35080416400;,Polymorphisms in dipeptidyl peptidase 4 reduce host cell entry of Middle East respiratory syndrome coronavirus,2020,Emerging Microbes and Infections,9,1,,155,168,,1,10.1080/22221751.2020.1713705,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078233058&doi=10.1080%2f22221751.2020.1713705&partnerID=40&md5=7107ccc98335d6d6fe73ba6ac5863ad2,"Infection Biology Unit, German Primate Center, Göttingen, Germany; Faculty of Biology and Psychology, University Göttingen, Göttingen, Germany; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Virology, Berlin, Germany; Institute of Virology, University of Veterinary Medicine Hannover, Hannover, Germany; Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, Hannover, Germany; Department of Physiological Chemistry, University of Veterinary Medicine Hannover, Hannover, Germany; German Centre for Infection Research, associated partner Charité, Berlin, Germany; Martsinovsky Institute of Medical Parasitology, Tropical and Vector Borne Diseases, Sechenov University, Moscow, Russian Federation","Kleine-Weber, H., Infection Biology Unit, German Primate Center, Göttingen, Germany, Faculty of Biology and Psychology, University Göttingen, Göttingen, Germany; Schroeder, S., Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Virology, Berlin, Germany; Krüger, N., Institute of Virology, University of Veterinary Medicine Hannover, Hannover, Germany, Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, Hannover, Germany; Prokscha, A., Department of Physiological Chemistry, University of Veterinary Medicine Hannover, Hannover, Germany; Naim, H.Y., Department of Physiological Chemistry, University of Veterinary Medicine Hannover, Hannover, Germany; Müller, M.A., Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Virology, Berlin, Germany, German Centre for Infection Research, associated partner Charité, Berlin, Germany, Martsinovsky Institute of Medical Parasitology, Tropical and Vector Borne Diseases, Sechenov University, Moscow, Russian Federation; Drosten, C., Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Virology, Berlin, Germany, German Centre for Infection Research, associated partner Charité, Berlin, Germany; Pöhlmann, S., Infection Biology Unit, German Primate Center, Göttingen, Germany, Faculty of Biology and Psychology, University Göttingen, Göttingen, Germany; Hoffmann, M., Infection Biology Unit, German Primate Center, Göttingen, Germany","Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV) causes a severe respiratory disease in humans. The MERS-CoV spike (S) glycoprotein mediates viral entry into target cells. For this, MERS-CoV S engages the host cell protein dipeptidyl peptidase 4 (DPP4, CD26) and the interface between MERS-CoV S and DPP4 has been resolved on the atomic level. Here, we asked whether naturally-occurring polymorphisms in DPP4, that alter amino acid residues required for MERS-CoV S binding, influence cellular entry of MERS-CoV. By screening of public databases, we identified fourteen such polymorphisms. Introduction of the respective mutations into DPP4 revealed that all except one (Δ346-348) were compatible with robust DPP4 expression. Four polymorphisms (K267E, K267N, A291P and Δ346-348) strongly reduced binding of MERS-CoV S to DPP4 and S protein-driven host cell entry, as determined using soluble S protein and S protein bearing rhabdoviral vectors, respectively. Two polymorphisms (K267E and A291P) were analyzed in the context of authentic MERS-CoV and were found to attenuate viral replication. Collectively, we identified naturally-occurring polymorphisms in DPP4 that negatively impact cellular entry of MERS-CoV and might thus modulate MERS development in infected patients. © 2020, © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd.",dipeptidyl peptidase 4; Middle East respiratory syndrome coronavirus; polymorphisms; receptor binding; spike glycoprotein,amino acid; dipeptidyl peptidase IV; vitronectin; animal cell; Article; BHK-21 cell line; Caco-2 cell line; controlled study; embryo; gene mutation; genetic polymorphism; HEK293T cell line; host cell; human; human cell; Middle East respiratory syndrome coronavirus; nonhuman; priority journal; protein expression; receptor binding; Vero cell line; virus entry; virus replication; virus spike,"Zaki, A.M., van Boheemen, S., Bestebroer, T.M., Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia (2012) N Engl J Med, 367 (19), pp. 1814-1820. , Nov 8; https://www.who.int/emergencies/mers-cov/en/, MERS situation update [updated 2019–05]. 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Perera, R.A., Wang, P., Gomaa, M.R., Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt, June 2013 (2013) Euro Surveill, 18 (36), p. 20574. , Sep 5; Shirato, K., Melaku, S.K., Kawachi, K., Middle East respiratory syndrome coronavirus in Dromedaries in Ethiopia Is Antigenically different from the Middle East Isolate EMC (2019) Front Microbiol, 10, p. 1326","Pöhlmann, S.; Infection Biology Unit, German Primate CenterGermany; email: spoehlmann@dpz.eu",,Taylor and Francis Ltd.,22221751,,,31964246,English,Emerg. Microbes Infect.,Article,Final,Open Access,Scopus,2-s2.0-85078233058,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wang X., Zhang X., He J.",57215853178;57215852066;57195296690;,Challenges to the system of reserve medical supplies for public health emergencies: Reflections on the outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic in China,2020,BioScience Trends,14,1,1043,,,,1,10.5582/BST.2020.01043,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081991213&doi=10.5582%2fBST.2020.01043&partnerID=40&md5=6fb94c5106d437ddb31a2d3a07afc29e,"Department of Health Policy Research, Shanghai Health Development Research Center, Shanghai Medical Information Center, Shanghai, China","Wang, X., Department of Health Policy Research, Shanghai Health Development Research Center, Shanghai Medical Information Center, Shanghai, China; Zhang, X., Department of Health Policy Research, Shanghai Health Development Research Center, Shanghai Medical Information Center, Shanghai, China; He, J., Department of Health Policy Research, Shanghai Health Development Research Center, Shanghai Medical Information Center, Shanghai, China","On December 31, 2019, the Wuhan Municipal Health Commission announced an outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), China is now at a critical period in the control of the epidemic. The Chinese Government has been taking a series of rapid, comprehensive, and effective prevention and control measures. As the pandemic has developed, a fact has become apparent: there is a serious dearth of emergency medical supplies, and especially an extreme shortage of personal protective equipment such as masks and medical protective clothing. This is one of the major factors affecting the progress of epidemic prevention and control. Although China has made great efforts to strengthen the ability to quickly respond to public health emergencies since the SARS outbreak in 2003 and it has clarified requirements for emergency supplies through legislation, the emergency reserve supplies program has not been effectively implemented, and there are also deficiencies in the types, quantity, and availability of emergency medical supplies. A sound system of emergency reserve supplies is crucial to the management of public health emergencies. Based on international experiences with pandemic control, the world should emphasize improving the system of emergency reserve medical supplies in the process of establishing and improving public health emergency response systems, and it should promote the establishment of international cooperative programs to jointly deal with public health emergencies of international concern in the future. © 2020 International Advancement Center for Medicine and Health Research Co., Ltd.",COVID-19; Medical supplies; Public health emergency; SARS-CoV-2,"COVID-19; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; China; communicable disease control; Coronavirus infection; emergency; epidemic; hospital equipment; human; organization and management; pandemic; protective equipment; public health; virus pneumonia; Betacoronavirus; China; Communicable Disease Control; Coronavirus Infections; Disease Outbreaks; Emergencies; Equipment and Supplies, Hospital; Humans; Pandemics; Personal Protective Equipment; 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(2020) Issuance of Guiding Opinions on Enhancing the Standardization and Devising of Responses to Healthrelated Emergencies, , http://www.nhc.gov.cn/yjb/s7859/201612/3a3b5ce97fa940c58a64ff1892f4b3e1.shtml, accessed February 4 (in Chinese); Esbitt, D., The Strategic National Stockpile: Roles and responsibilities of health care professionals for receiving the stockpile assets (2003) Disaster Manag Response, 1, pp. 68-70","He, J.; Shanghai Health Development Research Center, Shanghai Medical Information Center, No.1477 Beijing (W) Road, Jing'an District, China; email: hejiangjiang@shdrc.org",,"International Advancement Center for Medicine and Health Research Co., Ltd.",18817815,,,32062645,English,BioScience Trends,Article,Final,Open Access,Scopus,2-s2.0-85081991213,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Eickmann M., Gravemann U., Handke W., Tolksdorf F., Reichenberg S., Müller T.H., Seltsam A.",55913596100;6506175653;57201130452;53868455500;6507350124;7403045563;55942944100;,"Inactivation of three emerging viruses – severe acute respiratory syndrome coronavirus, Crimean–Congo haemorrhagic fever virus and Nipah virus – in platelet concentrates by ultraviolet C light and in plasma by methylene blue plus visible light",2020,Vox Sanguinis,,,,,,,2,10.1111/vox.12888,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077906975&doi=10.1111%2fvox.12888&partnerID=40&md5=47d39d1b100e679e375b58f70f3b7789,"Institute for Virology, Philipps University Marburg, Marburg, Germany; German Red Cross Blood Service NSTOB, Springe, Germany; Maco Pharma International GmbH, Langen, Germany","Eickmann, M., Institute for Virology, Philipps University Marburg, Marburg, Germany; Gravemann, U., German Red Cross Blood Service NSTOB, Springe, Germany; Handke, W., German Red Cross Blood Service NSTOB, Springe, Germany; Tolksdorf, F., Maco Pharma International GmbH, Langen, Germany; Reichenberg, S., Maco Pharma International GmbH, Langen, Germany; Müller, T.H., German Red Cross Blood Service NSTOB, Springe, Germany; Seltsam, A., German Red Cross Blood Service NSTOB, Springe, Germany","Background: Emerging viruses like severe acute respiratory syndrome coronavirus (SARS-CoV), Crimean–Congo haemorrhagic fever virus (CCHFV) and Nipah virus (NiV) have been identified to pose a potential threat to transfusion safety. In this study, the ability of the THERAFLEX UV-Platelets and THERAFLEX MB-Plasma pathogen inactivation systems to inactivate these viruses in platelet concentrates and plasma, respectively, was investigated. Materials and methods: Blood products were spiked with SARS-CoV, CCHFV or NiV, and then treated with increasing doses of UVC light (THERAFLEX UV-Platelets) or with methylene blue (MB) plus increasing doses of visible light (MB/light; THERAFLEX MB-Plasma). Samples were taken before and after treatment with each illumination dose and tested for residual infectivity. Results: Treatment with half to three-fourths of the full UVC dose (0·2 J/cm2) reduced the infectivity of SARS-CoV (≥3·4 log), CCHFV (≥2·2 log) and NiV (≥4·3 log) to the limit of detection (LOD) in platelet concentrates, and treatment with MB and a fourth of the full light dose (120 J/cm2) decreased that of SARS-CoV (≥3·1 log), CCHFV (≥3·2 log) and NiV (≥2·7 log) to the LOD in plasma. Conclusion: Our study demonstrates that both THERAFLEX UV-Platelets (UVC) and THERAFLEX MB-Plasma (MB/light) effectively reduce the infectivity of SARS-CoV, CCHFV and NiV in platelet concentrates and plasma, respectively. © 2020 International Society of Blood Transfusion",methylene blue; pathogen inactivation; plasma; platelet concentrates; ultraviolet light,,"Stramer, S.L., Hollinger, F.B., Katz, L.M., Emerging infectious disease agents and their potential threat to transfusion safety (2009) Transfusion, 49, pp. 1S-29S; Stramer, S.L., Current perspectives in transfusion-transmitted infectious diseases: emerging and re-emerging infections (2014) ISBT Sci Ser, 9, pp. 30-36; Bahar, B., Schulz, W.L., Gokhale, A., Blood utilisation and transfusion reactions in adult patients transfused with conventional or pathogen-reduced platelets (2019) Br J Haematol, , https://doi.org/10.1111/bjh.16187, [Epub ahead of print]; Seltsam, A., Muller, T.H., Update on the use of pathogen-reduced human plasma and platelet concentrates (2013) Br J Haematol, 162, pp. 442-454; Mohr, H., Steil, L., Gravemann, U., A novel approach to pathogen reduction in platelet concentrates using short-wave ultraviolet light (2009) Transfusion, 49, pp. 2612-2624; Seltsam, A., Muller, T.H., UVC irradiation for pathogen reduction of platelet concentrates and plasma (2011) Transfus Med Hemother, 38, pp. 43-54; Kim, S., Handke, W., Gravemann, U., Mitochondrial DNA multiplex real-time polymerase chain reaction inhibition assay for quality control of pathogen inactivation by ultraviolet C light in platelet concentrates (2018) Transfusion, 58, pp. 758-765; Mohr, H., Lambrecht, B., Selz, A., Photodynamic virus inactivation of blood components (1995) Immunol Invest, 24, pp. 73-85; Seghatchian, J., Walker, W.H., Reichenberg, S., Updates on pathogen inactivation of plasma using Theraflex methylene blue system (2008) Transfus Apher Sci, 38, pp. 271-280; Politis, C., Kavallierou, L., Hantziara, S., Haemovigilance data on the use of methylene blue virally inactivated fresh frozen plasma with the Theraflex MB-Plasma System in comparison to quarantine plasma: 11 years' experience (2014) Transfus Med, 24, pp. 316-320; Williamson, L.M., Cardigan, R., Prowse, C.V., Methylene blue-treated fresh-frozen plasma: what is its contribution to blood safety? (2003) Transfusion, 43, pp. 1322-1329; Faddy, H.M., Fryk, J.J., Prow, N.A., Inactivation of dengue, chikungunya, and Ross River viruses in platelet concentrates after treatment with ultraviolet C light (2016) Transfusion, 56, pp. 1548-1555; Fryk, J.J., Marks, D.C., Hobson-Peters, J., Reduction of Zika virus infectivity in platelet concentrates after treatment with ultraviolet C light and in plasma after treatment with methylene blue and visible light (2017) Transfusion, 57, pp. 2677-2682; Eickmann, M., Gravemann, U., Handke, W., Inactivation of Ebola virus and Middle East respiratory syndrome coronavirus in platelet concentrates and plasma by ultraviolet C light and methylene blue plus visible light, respectively (2018) Transfusion, 58, pp. 2202-2207; Arnason, N.A., Johannson, F., Landro, R., Pathogen inactivation with amotosalen plus UVA illumination minimally impacts microRNA expression in platelets during storage under standard blood banking conditions (2019) Transfusion, 59, pp. 3727-3735; Castro, E., Girones, N., Guerrero, N., The effectiveness of UVC pathogen inactivation system on reducing the Trypansosoma cruzi and Leishmania infantum burden in platelets (2008) Vox Sang, 95, p. 290; Castro, E., Gonzalez, L.M., Rubio, J.M., The efficacy of the ultraviolet C pathogen inactivation system in the reduction of Babesia divergens in pooled buffy coat platelets (2014) Transfusion, 54, pp. 2207-2216; Gravemann, U., Handke, W., Lambrecht, B., Ultraviolet C light efficiently inactivates nonenveloped hepatitis A virus and feline calicivirus in platelet concentrates (2018) Transfusion, 58, pp. 2669-2674; Gravemann, U., Handke, W., Muller, T.H., Bacterial inactivation of platelet concentrates with the THERAFLEX UV-Platelets pathogen inactivation system (2019) Transfusion, 59, pp. 1324-1332; Seghatchian, J., Struff, W.G., Reichenberg, S., Main properties of the THERAFLEX MB-plasma system for pathogen reduction (2011) Transf Med Hemother, 38, pp. 55-64; Spearman, C., The method of ""right and wrong cases"" (""constant stimuli"") without Gauss's formulae (1908) Br J Psychol, 2, pp. 277-282; Kaerber, G., Beitrag zur kollektiven Behandlung pharmakologischer Reihenversuche (1931) Naunyn Schmiedebergs Arch Exp Pathol Pharmakol, 162, pp. 480-483; Agafonov, A.P., Gus'kov, A.A., Ternovoi, V.A., Primary characterization of SARS coronavirus strain Frankfurt 1 (2004) Dokl Biol Sci, 394, pp. 58-60; Olschlager, S., Gabriel, M., Schmidt-Chanasit, J., Complete sequence and phylogenetic characterisation of Crimean-Congo hemorrhagic fever virus from Afghanistan (2011) J Clin Virol, 50, pp. 90-92; Wild, T.F., Henipaviruses: a new family of emerging Paramyxoviruses (2009) Pathol Biol (Paris), 57, pp. 188-196; Woolhouse, M.E., Haydon, D.T., Antia, R., Emerging pathogens: the epidemiology and evolution of species jumps (2005) Trends Ecol Evol, 20, pp. 238-244; de Wit, E., van Doremalen, N., Falzarano, D., SARS and MERS: recent insights into emerging coronaviruses (2016) Nat Rev Microbiol, 14, pp. 523-534; Dunstan, R.A., Seed, C.R., Keller, A.J., Emerging viral threats to the Australian blood supply (2008) Aust N Z J Public Health, 32, pp. 354-360; Bente, D.A., Forrester, N.L., Watts, D.M., Crimean-Congo hemorrhagic fever: history, epidemiology, pathogenesis, clinical syndrome and genetic diversity (2013) Antiviral Res, 100, pp. 159-189; Conger, N.G., Paolino, K.M., Osborn, E.C., Health care response to CCHF in US soldier and nosocomial transmission to health care providers, Germany, 2009 (2015) Emerg Infect Dis, 21, pp. 23-31; Sharma, V., Kaushik, S., Kumar, R., Emerging trends of Nipah virus: A review (2019) Rev Med Virol, 29; Ang, B.S.P., Lim, T.C.C., Wang, L., Nipah virus infection (2018) J Clin Microbiol, 56 (6); Nikolay, B., Salje, H., Hossain, M.J., Transmission of nipah virus - 14 years of investigations in Bangladesh (2019) N Engl J Med, 380, pp. 1804-1814; McCullough, J., Alter, H.J., Ness, P.M., Interpretation of pathogen load in relationship to infectivity and pathogen reduction efficacy (2019) Transfusion, 59, pp. 1132-1146","Seltsam, A.; German Red Cross Blood Service NSTOBGermany; email: axel.seltsam@bsd-nstob.de",,Blackwell Publishing Ltd,429007,,VOSAA,31930543,English,Vox Sang.,Article,Article in Press,Open Access,Scopus,2-s2.0-85077906975,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Lai C.-C., Wang C.-Y., Wang Y.-H., Hsueh S.-C., Ko W.-C., Hsueh P.-R.",57214801883;57215773855;57210707373;57205475327;57216141184;7103390478;,"Global epidemiology of coronavirus disease 2019 (COVID-19): disease incidence, daily cumulative index, mortality, and their association with country healthcare resources and economic status",2020,International Journal of Antimicrobial Agents,,,105946,,,,,10.1016/j.ijantimicag.2020.105946,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082511011&doi=10.1016%2fj.ijantimicag.2020.105946&partnerID=40&md5=9cce92b1f4e6135bdf5a0c16edb7b947,"Department of Internal Medicine, Kaohsiung Veterans General Hospital, Tainan Branch, Tainan, Taiwan; Department of Internal Medicine, Cardinal Tien Hospital and School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan; Medical Research Center, Cardinal Tien Hospital and School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan; Department of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan","Lai, C.-C., Department of Internal Medicine, Kaohsiung Veterans General Hospital, Tainan Branch, Tainan, Taiwan; Wang, C.-Y., Department of Internal Medicine, Cardinal Tien Hospital and School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan; Wang, Y.-H., Medical Research Center, Cardinal Tien Hospital and School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan; Hsueh, S.-C., Department of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Ko, W.-C., Department of Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Hsueh, P.-R., Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan, Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan","It has been 2 months since the first case of coronavirus disease 2019 (COVID-19) was reported in Wuhan, China. So far, COVID-19 has affected 85 403 patients in 57 countries/territories and has caused 2924 deaths in 9 countries. However, epidemiological data differ between countries. Although China had higher morbidity and mortality than other sites, the number of new daily cases in China has been lower than outside of China since 26 February 2020. The incidence ranged from 61.44 per 1 000 000 people in the Republic of Korea to 0.0002 per 1 000 000 people in India. The daily cumulative index (DCI) of COVID-19 (cumulative cases/no. of days between the first reported case and 29 February 2020) was greatest in China (1320.85), followed by the Republic of Korea (78.78), Iran (43.11) and Italy (30.62). However, the DCIs in other countries/territories were <10 per day. Several effective measures including restricting travel from China, controlling the distribution of masks, extensive investigation of COVID-19 spread, and once-daily press conferences by the government to inform and educate people were aggressively conducted in Taiwan. This is probably the reason why there was only 39 cases (as of 29 February 2020) with a DCI of 1 case per day in Taiwan, which is much lower than that of nearby countries such as the Republic of Korea and Japan. In addition, the incidence and mortality were correlated with the DCI. However, further study and continued monitoring are needed to better understand the underlying mechanism of COVID-19. © 2020 The Authors",Coronavirus disease 2019; Country healthcare resources; COVID-19; Daily cumulative index; Disease incidence; Mortality,,"Coronavirus disease 2019 (COVD-19). Situation report – 40 (2020), https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200229-sitrep-40-covid-19.pdf?sfvrsn=849d0665_2, WHO Geneva, Switzerland Data as reported by 10AM CET 29 February 2020 [accessed 17 March 2020]; Guan, W.J., Ni, Z.Y., Hu, Y., Liang, W.H., Ou, C.Q., He, J.X., Clinical characteristics of coronavirus disease 2019 in China (2020) N Engl J Med, , [Epub ahead of print]; Lai, C.C., Shih, T.P., Ko, W.C., Tang, H.J., Hsueh, P.R., Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): the epidemic and the challenges (2020) Int J Antimicrob Agents, 55; Lai, C.C., Liu, Y.H., Wang, C.Y., Wang, Y.H., Hsueh, S.C., Yen, M.Y., Asymptomatic carrier state, acute respiratory disease, and pneumonia due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): facts and myths (2020) J Microbiol Immunol Infect; Wu, Z., McGoogan, J.M., Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China. Summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention (2020) JAMA, , [Epub ahead of print]; Rocklov, J., Sjodin, H., Wilder-Smith, A., COVID-19 outbreak on the Diamond Princess cruise ship: estimating the epidemic potential and effectiveness of public health countermeasures (2020) J Travel Med, , pii: taaa030 [Epub ahead of print]; Wang, C.J., Ng, C.Y., Brook, R.H., Response to COVID-19 in Taiwan: big data analytics, new technology, and proactive testing (2020) JAMA, , [Epub ahead of print]; Ji, Y.M.Z., Peppelenbosch, M.P., Pan, Q., Potential association between COVID-19 mortality and health-care resource availability (2020) Lancet Glob Health, , [Epub ahead of print]; Health Care Index by country, (2020), https://www.numbeo.com/health-care/rankings_by_country.jsp, [accessed 1 March 2020]; Measuring performance on the Healthcare Access and Quality Index for 195 countries and territories and selected subnational locations: a systematic analysis from the Global Burden of Disease Study 2016 (2018) Lancet, 391, pp. 2236-2271","Hsueh, P.-R.; Departments of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital, Number 7, Chung-Shan South Road, Taiwan; email: hsporen@ntu.edu.tw",,Elsevier B.V.,9248579,,IAAGE,32199877,English,Int. J. Antimicrob. Agents,Article,Article in Press,Open Access,Scopus,2-s2.0-85082511011,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Qi F., Qian S., Zhang S., Zhang Z.",57215934051;57215936243;24339682000;8965136800;,Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses,2020,Biochemical and Biophysical Research Communications,,,,,,,,10.1016/j.bbrc.2020.03.044,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082431635&doi=10.1016%2fj.bbrc.2020.03.044&partnerID=40&md5=a62bcc2ec2a1586c119cc58000c6f9cf,"Institute of Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, Guangdong Province 518100, China; The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong Province 518112, China; Shanghai Public Health Clinical Center and Institute of Biomedical Sciences, Fudan University, Shanghai, China","Qi, F., Institute of Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, Guangdong Province 518100, China; Qian, S., Institute of Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, Guangdong Province 518100, China; Zhang, S., Shanghai Public Health Clinical Center and Institute of Biomedical Sciences, Fudan University, Shanghai, China; Zhang, Z., Institute of Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, Guangdong Province 518100, China, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong Province 518112, China","The new coronavirus (SARS-CoV-2) outbreak from December 2019 in Wuhan, Hubei, China, has been declared a global public health emergency. Angiotensin I converting enzyme 2 (ACE2), is the host receptor by SARS-CoV-2 to infect human cells. Although ACE2 is reported to be expressed in lung, liver, stomach, ileum, kidney and colon, its expressing levels are rather low, especially in the lung. SARS-CoV-2 may use co-receptors/auxiliary proteins as ACE2 partner to facilitate the virus entry. To identify the potential candidates, we explored the single cell gene expression atlas including 119 cell types of 13 human tissues and analyzed the single cell co-expression spectrum of 51 reported RNA virus receptors and 400 other membrane proteins. Consistent with other recent reports, we confirmed that ACE2 was mainly expressed in lung AT2, liver cholangiocyte, colon colonocytes, esophagus keratinocytes, ileum ECs, rectum ECs, stomach epithelial cells, and kidney proximal tubules. Intriguingly, we found that the candidate co-receptors, manifesting the most similar expression patterns with ACE2 across 13 human tissues, are all peptidases, including ANPEP, DPP4 and ENPEP. Among them, ANPEP and DPP4 are the known receptors for human CoVs, suggesting ENPEP as another potential receptor for human CoVs. We also conducted “CellPhoneDB” analysis to understand the cell crosstalk between CoV-targets and their surrounding cells across different tissues. We found that macrophages frequently communicate with the CoVs targets through chemokine and phagocytosis signaling, highlighting the importance of tissue macrophages in immune defense and immune pathogenesis. © 2020 Shenzhen Third People's Hospital",ACE2; Co-receptor; Coronaviruses; Macrophage; SARS-CoV-2; scRNA-seq,,"Ahlquist, P., Host factors in positive-strand RNA virus genome replication (2003) J. Virol., 77 (15), pp. 8181-8186; Huang, C., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395 (10223), pp. 497-506; Chazal, N., Gerlier, D., Virus entry, assembly, budding, and membrane rafts (2003) Microbiol. Mol. Biol. Rev., 67 (2), pp. 226-237. , table of contents; Lu, R., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet, 395 (10224), pp. 565-574; Hoffmann, M., The Novel Coronavirus 2019 (2019-nCoV) Uses the SARS-Coronavirus Receptor ACE2 and the Cellular Protease TMPRSS2 for Entry into Target Cells (2020), p. 2020. , bioRxiv 01.31.929042; Xin Zou, K.C., Jiawei Zou, Peiyi Han, Jie Hao, Zeguang Han, The single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to Wuhan 2019-nCoV infection. Front. Med. [Epub ahead of print] doi: 10.1007/s11684-020-0754-0; Zhang, Z., Cell membrane proteins with high N-glycosylation, high expression and multiple interaction partners are preferred by mammalian viruses as receptors (2019) Bioinformatics, 35 (5), pp. 723-728; Reyfman, P.A., Single-cell transcriptomic analysis of human lung provides insights into the pathobiology of pulmonary fibrosis (2019) Am. J. Respir. Crit. Care Med., 199 (12), pp. 1517-1536; MacParland, S.A., Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations (2018) Nat. Commun., 9 (1), p. 4383; Wang, Y., Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine (2020) J. Exp. Med., 217 (2); Dobie, R., Single-cell transcriptomics uncovers zonation of function in the mesenchyme during liver fibrosis (2019) Cell Rep., 29 (7), pp. 1832-1847 e8; Oetjen, K.A., Human bone marrow assessment by single-cell RNA sequencing, mass cytometry, and flow cytometry (2018) JCI Insight, 3 (23); Kim, D., Targeted therapy guided by single-cell transcriptomic analysis in drug-induced hypersensitivity syndrome: a case report (2020) Nat. Med., 26, pp. 236-243; Madissoon, E., scRNA-seq assessment of the human lung, spleen, and esophagus tissue stability after cold preservation (2019) Genome Biol., 21 (1), p. 1; Parikh, K., Colonic epithelial cell diversity in health and inflammatory bowel disease (2019) Nature, 567 (7746), pp. 49-55; Voigt, A.P., Single-cell transcriptomics of the human retinal pigment epithelium and choroid in health and macular degeneration (2019) Proc. Natl. Acad. Sci. U. S. A., 116 (48), pp. 24100-24107; Zhang, P., Dissecting the single-cell transcriptome network underlying gastric premalignant lesions and early gastric cancer (2019) Cell Rep., 27 (6), pp. 1934-1947 e5; Liao, J., Single-cell RNA sequencing of human kidney (2020) Sci Data, 7 (1), p. 4; Stuart, T., Comprehensive integration of single-cell data (2019) Cell, 177 (7), pp. 1888-1902 e21; Korsunsky, I., Fast, sensitive and accurate integration of single-cell data with harmony (2019) Nat. Methods, 16 (12), pp. 1289-1296; Efremova, M., v2.0: Inferring Cell-Cell Communication from Combined Expression of Multi-Subunit Receptor-Ligand Complexes (2019), bioRxiv; Lomize, A.L., Membranome: a database for proteome-wide analysis of single-pass membrane proteins (2017) Nucleic Acids Res., 45 (D1), pp. D250-D255; Holmes, R.S., Spradling-Reeves, K.D., Cox, L.A., Mammalian Glutamyl aminopeptidase genes (ENPEP) and proteins: comparative studies of a major contributor to arterial hypertension (2017) J. Data Min. Genom. Proteonomics, 8 (2); Li, F., Receptor recognition mechanisms of coronaviruses: a decade of structural studies (2015) J. Virol., 89 (4), pp. 1954-1964; Smith, R.D., Responding to global infectious disease outbreaks: lessons from SARS on the role of risk perception, communication and management (2006) Soc. Sci. Med., 63 (12), pp. 3113-3123; (2017), Middle East Respiratory Syndrome Coronavirus (MERS-CoV). World Health Organization, Retrieved 10 April; Chen, N., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395 (10223), pp. 507-513; Wang, S., Endocytosis of the receptor-binding domain of SARS-CoV spike protein together with virus receptor ACE2 (2008) Virus Res., 136 (1-2), pp. 8-15; Yang, Z.Y., pH-dependent entry of severe acute respiratory syndrome coronavirus is mediated by the spike glycoprotein and enhanced by dendritic cell transfer through DC-SIGN (2004) J. Virol., 78 (11), pp. 5642-5650; Gramberg, T., LSECtin interacts with filovirus glycoproteins and the spike protein of SARS coronavirus (2005) Virology, 340 (2), pp. 224-236; Marzi, A., DC-SIGN and DC-SIGNR interact with the glycoprotein of Marburg virus and the S protein of severe acute respiratory syndrome coronavirus (2004) J. Virol., 78 (21), pp. 12090-12095; Peck, K.M., Permissivity of dipeptidyl peptidase 4 orthologs to Middle East respiratory syndrome coronavirus is governed by glycosylation and other complex determinants (2017) J. Virol., 91 (19); Le Page, C., Interferon activation and innate immunity (2000) Rev. Immunogenet., 2 (3), pp. 374-386; Perry, A.K., The host type I interferon response to viral and bacterial infections (2005) Cell Res., 15 (6), pp. 407-422; McNab, F., Type I interferons in infectious disease (2015) Nat. Rev. Immunol., 15 (2), pp. 87-103; Hansen, T.H., Bouvier, M., MHC class I antigen presentation: learning from viral evasion strategies (2009) Nat. Rev. Immunol., 9 (7), pp. 503-513; Goulder, P.J., Watkins, D.I., Impact of MHC class I diversity on immune control of immunodeficiency virus replication (2008) Nat. Rev. Immunol., 8 (8), pp. 619-630","Zhang, Z.; Institute of Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's HospitalChina; email: zhangzheng1975@aliyun.com",,Elsevier B.V.,0006291X,,BBRCA,32199615,English,Biochem. Biophys. Res. Commun.,Article,Article in Press,Open Access,Scopus,2-s2.0-85082431635,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhao X., Liu B., Yu Y., Wang X., Du Y., Gu J., Wu X.",57216120101;57209511648;55731443600;14833437100;57215815219;57215686809;14826120200;,The characteristics and clinical value of chest CT images of novel coronavirus pneumonia,2020,Clinical Radiology,75,5,,335,340,,,10.1016/j.crad.2020.03.002,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081951370&doi=10.1016%2fj.crad.2020.03.002&partnerID=40&md5=4f84e50e8f1754026db978cc91021f81,"Department of Radiology, The First Affiliated Hospital of Anhui Medical University, China; Department of Radiology, Fuyang Second People's Hospital, China","Zhao, X., Department of Radiology, The First Affiliated Hospital of Anhui Medical University, China; Liu, B., Department of Radiology, The First Affiliated Hospital of Anhui Medical University, China; Yu, Y., Department of Radiology, The First Affiliated Hospital of Anhui Medical University, China; Wang, X., Department of Radiology, The First Affiliated Hospital of Anhui Medical University, China; Du, Y., Department of Radiology, Fuyang Second People's Hospital, China; Gu, J., Department of Radiology, Fuyang Second People's Hospital, China; Wu, X., Department of Radiology, The First Affiliated Hospital of Anhui Medical University, China","AIM: To investigate the characteristics and clinical value of chest computed tomography (CT) images of novel coronavirus pneumonia (NCP). MATERIALS AND METHODS: Clinical data and CT images of 80 cases of NCP were collected. The clinical manifestations and laboratory test results of the patients were analysed. The lesions in each lung segment of the patient's chest CT images were characterised. Lesions were scored according to length and diffusivity. RESULTS: The main clinical manifestations were fever, dry cough, fatigue, a little white sputum, or diarrhoea. A total of 1,702 scored lesions were found in the first chest CT images of 80 patients. The lesions were located mainly in the subpleural area of the lungs (92.4%). Most of the lesions were ground-glass opacity, and subsequent fusions could increase in range and spread mainly in the subpleural area. Pulmonary consolidation accounted for 44.1% of all of the lesions. Of the 80 cases, 76 patients (95%) had bilateral lung disease, four (5%) patients had unilateral lung disease, and eight (10%) patients had cord shadow. CONCLUSION: The chest CT of NCP patients is characterised by the onset of bilateral ground-glass lesions located in the subpleural area of the lung, and progressive lesions that result in consolidation with no migratory lesions. Pleural effusions and mediastinal lymphadenopathy are rare. As patients can have inflammatory changes in the lungs alongside a negative early nucleic acid test, chest CT, in combination with epidemiological and laboratory tests, is a useful examination to evaluate the disease and curative effect. © 2020 The Royal College of Radiologists",,,"Cha-Yeung, M., Xu, R.H., SARS: epidemiology (2003) Respirology, 8, pp. S9-S14; World Health Organization, WHO handbook for guideline development (2014), https://apps.who.int/iris/handle/10665/145714, 2nd edn; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395 (10223), pp. 507-513; General Office of National Health Committee, Office of State Administration of Traditional Chinese Medicine. Notice on the issuance of a programme for the diagnosis and treatment of novel coronavirus (2019-nCoV) infected pneumonia (trial 4th edn) (2020-0128) http://bgs.satcm.gov.cn/zhengcewenjian/2020-01-28/12576.html; Lu, H., Stratton, C.W., Tang, Y.W., Outbreak of pneumonia of unknown etiology in Wuhan, China: the mystery and the miracle (2020) J Med Virol, 92 (4), pp. 401-402; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395 (10223), pp. 497-506; Cheng, A., Zhang, W., Xie, Y., Expression, purification, and characterization of SARS coronavirus RNA polymerase (2005) Virology, 335 (2), pp. 165-176; Reusken, C., Farag, E., Jonges, M., Middle East respiratory syndrome coronavirus (MERS-CoV) RNA and neutralising antibodies in milk collected according to local customs from dromedary camels, Qatar, April 2014 (2014) Eurosurveillance, 19 (23), p. 20829; Ng, D.L., AL Hosani, F., Keating, M.K., Clinicopathologic, immunohistochemical, and ultrastructural findings of a fatal case of Middle East respiratory syndrome coronavirus infection in the United Arab Emirates, April 2014 (2016) Am J Pathol, 186 (3), pp. 652-658; Kim, E.A., Lee, K.S., Primack, S.L., Viral pneumonias in adults: radiologic and pathologic findings (2002) RadioGraphics, 22, pp. S137-S149; Shen, Z., Ning, F., Zhou, W., Superspreading SARS events, Beijing, 2003 (2004) Emerg Infect Dis, 10 (2), p. 256; Wu, C., Xu, X., Lu, H., Analysis of the chest X-ray manifestations in SARS patients treated with compound glycyrrhizin (2004) China Pharm, p. 1; Liu, J.-X., Jiang, S.-F., Chen, B.-H., Image appearances of severe acute respiratory syndrome (a preliminary study of 260 cases) (2003) Chin J Med Imaging Technol, 19 (7), pp. 790-792; Nicolaou, S., AL-Nakshabandi, N.A., MÜLLER, N.L., SARS: imaging of severe acute respiratory syndrome (2003) AJR Am J Roentgenol, 180 (5), pp. 1247-1249; Wang, C.-H., Liu, C.-Y., Wan, Y.-L., Persistence of lung inflammation and lung cytokines with high-resolution CT abnormalities during recovery from SARS (2005) Resp Res, 6 (1), p. 42; Ajlan, A.M., Ahyad, R.A., Jamjoom, L.G., Middle East respiratory syndrome coronavirus (MERS-CoV) infection: chest CT findings (2014) AJR Am J Roentgenol, 203 (4), pp. 782-787; Koo, H.J., Lim, S., Choe, J., Radiographic and CT features of viral pneumonia (2018) RadioGraphics, 38 (3), pp. 719-739; Gang, C., Daqing, M., Chest X-ray appearances in SARS: analysis of 72 cases (2003) Chin J Radiol, 37 (9), pp. 784-788; MÜLler, N.L., Ooi, G.C., Khong, P.L., High-resolution CT findings of severe acute respiratory syndrome at presentation and after admission (2004) AJR Am J Roentgenol, 182 (1), pp. 39-44; Hsieh, S.-C., Chan, W.P., Chien, J.C.-W., Radiographic appearance and clinical outcome correlates in 26 patients with severe acute respiratory syndrome (2004) AJR Am J Roentgenol, 182 (5), pp. 1119-1122","Wu, X.; Department of Radiology, The First Affiliated Hospital of Anhui Medical UniversityChina; email: duobi2004@126.com",,W.B. Saunders Ltd,99260,,CLRAA,32199619,English,Clin. Radiol.,Article,Final,Open Access,Scopus,2-s2.0-85081951370,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Chen X., Chughtai A.A., MacIntyre C.R.",57194504815;55511253500;57203198705;,Application of a Risk Analysis Tool to Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Outbreak in Saudi Arabia,2020,Risk Analysis,,,,,,,,10.1111/risa.13472,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081737973&doi=10.1111%2frisa.13472&partnerID=40&md5=f3d11f2828fda8d35cdfe48af03d6dd1,"Biosecurity Program, Kirby Institute, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia; School of Public Health and Community Medicine, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia; College of Public Service and Community Solutions, Arizona State University, Tempe, AZ, United States; College of Health Solutions, Arizona State University, Tempe, AZ, United States","Chen, X., Biosecurity Program, Kirby Institute, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia; Chughtai, A.A., School of Public Health and Community Medicine, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia; MacIntyre, C.R., Biosecurity Program, Kirby Institute, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia, College of Public Service and Community Solutions, Arizona State University, Tempe, AZ, United States, College of Health Solutions, Arizona State University, Tempe, AZ, United States","The Grunow–Finke assessment tool (GFT) is an accepted scoring system for determining likelihood of an outbreak being unnatural in origin. Considering its high specificity but low sensitivity, a modified Grunow–Finke tool (mGFT) has been developed with improved sensitivity. The mGFT has been validated against some past disease outbreaks, but it has not been applied to ongoing outbreaks. This study is aimed to score the outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) in Saudi Arabia using both the original GFT and mGFT. The publicly available data on human cases of MERS-CoV infections reported in Saudi Arabia (2012–2018) were sourced from the FluTrackers, World Health Organization, Saudi Ministry of Health, and published literature associated with MERS outbreaks investigations. The risk assessment of MERS-CoV in Saudi Arabia was analyzed using the original GFT and mGFT criteria, algorithms, and thresholds. The scoring points for each criterion were determined by three researchers to minimize the subjectivity. The results showed 40 points of total possible 54 points using the original GFT (likelihood: 74%), and 40 points of a total possible 60 points (likelihood: 67%) using the mGFT, both tools indicating a high likelihood that human MERS-CoV in Saudi Arabia is unnatural in origin. The findings simply flag unusual patterns in this outbreak, but do not prove unnatural etiology. Proof of bioattacks can only be obtained by law enforcement and intelligence agencies. This study demonstrated the value and flexibility of the mGFT in assessing and predicting the risk for an ongoing outbreak with simple criteria. © 2020 Society for Risk Analysis",Algorithm; bioterrorism; MERS-CoV; outbreak investigation; risk analysis; scoring system; unnatural epidemic,Algorithms; Bioterrorism; Risk analysis; Disease outbreaks; Intelligence agencies; MERS-CoV; outbreak investigation; Risk analysis tools; Scoring systems; unnatural epidemic; World Health Organization; Risk assessment,"Ajisegiri, W.S., Chughtai, A.A., MacIntyre, C.R., A risk analysis approach to prioritizing epidemics: Ebola virus disease in West Africa as a case study (2018) Risk Analysis, 38 (3), pp. 429-441. , https://doi.org/10.1111/risa.12876; (2018) Biological weapons convention signatories and states-parties, , https://www.armscontrol.org/factsheets/bwcsig, Retrieved from; Assiri, A., McGeer, A., Perl, T.M., Price, C.S., Al-Rabeeah, A.A., Cummings, D.A., Team, K.M.C.I., Hospital outbreak of Middle East respiratory syndrome coronavirus (2013) New England Journal of Medicine, 369 (5), pp. 407-416. , https://doi.org/10.1056/NEJMoa1306742; 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MacIntyre, C.R., Engells, T.E., Scotch, M., Heslop, D.J., Gumel, A.B., Poste, G., Lim, S., Converging and emerging threats to health security (2017) Environment Systems and Decisions, 38, pp. 198-207; Modjarrad, K., MERS-CoV vaccine candidates in development: The current landscape (2016) Vaccine, 34 (26), pp. 2982-2987. , https://doi.org/10.1016/j.vaccine.2016.03.104; Modjarrad, K., Roberts, C.C., Mills, K.T., Castellano, A.R., Paolino, K., Muthumani, K., Maslow, J.N., Safety and immunogenicity of an anti-Middle East respiratory syndrome coronavirus DNA vaccine: A phase 1, open-label, single-arm, dose-escalation trial (2019) Lancet Infectious Diseases, 19 (9), pp. 1013-1022. , https://doi.org/10.1016/s1473-3099(19)30266-x; Mohd, H.A., Al-Tawfiq, J.A., Memish, Z.A., Middle East respiratory syndrome coronavirus (MERS-CoV) origin and animal reservoir (2016) Virology Journal, 13, p. 87. , https://doi.org/10.1186/s12985-016-0544-0; Oboho, I.K., Tomczyk, S.M., Al-Asmari, A.M., Banjar, A.A., Al-Mugti, H., Aloraini, M.S., Madani, T.A., 2014 MERS-CoV outbreak in Jeddah - A link to health care facilities (2015) New England Journal of Medicine, 372 (9), pp. 846-854. , https://doi.org/10.1056/NEJMoa1408636; 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Wallinga, J., Teunis, P., Different epidemic curves for severe acute respiratory syndrome reveal similar impacts of control measures (2004) American Journal of Epidemiology, 160 (6), pp. 509-516. , https://doi.org/10.1093/aje/kwh255; Wheat, R.P., Zuckerman, A., Rantz, L.A., Infection due to chromobacteria; report of 11 cases (1951) A.M.A. Archives of Internal Medicine, 88 (4), pp. 461-466; (2017) Middle East respiratory syndrome covonavirus (MERS-CoV) fact sheet, , http://www.who.int/mediacentre/factsheets/mers-cov/en/, Retrieved from; (2018) MERS situation update, December 2018, , http://www.emro.who.int/pandemic-epidemic-diseases/mers-cov/mers-situation-update-december-2018.html, Retrieved from; (2018) SARS (Severe Acute Respiratory Syndrome), , http://www.who.int/ith/diseases/sars/en/, Retrieved from; (2019) Middle East respiratory syndrome coronavirus (MERS-CoV), , http://www.who.int/emergencies/mers-cov/en/, Retrieved from; (2019) Smallpox, , https://www.who.int/csr/disease/smallpox/en/, Retrieved from; Zaki, A.M., Van Boheemen, S., Bestebroer, T.M., Osterhaus, A.D., Fouchier, R.A., Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia (2012) New England Journal of Medicine, 367 (19), pp. 1814-1820","Chen, X.; Biosecurity Program, Kirby Institute, Faculty of Medicine, University of New South WalesAustralia; email: xinjessiechen@protonmail.com",,Blackwell Publishing Inc.,2724332,,RIAND,,English,Risk Anal.,Article,Article in Press,Open Access,Scopus,2-s2.0-85081737973,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Kong I., Park Y., Woo Y., Lee J., Cha J., Choi J., Kim Y., Kim J., Park S., Yum M., Kim T., Jo J., Kim M., Lee D., Kim J., Park S., Bahk H., Yu J., Kwon J., Kim H., Shin N., Lee S., In H., Jung J., Cho S., Jeon B., Kim D., Jin G., Kim S., Kim S., Kim Y., Kim E., Kim B.I., Kim H., Lee H., Jin Y., Kim J., Kim H., Ryu B., Shin S., Shin E., Lee J., Lee S., Jang Y., Choi E., Hyun J., Ko D., Seo G., Kwon S., Park E., Choi S., Hwang S., Lee S., Kang B., Park J., Lee D., Jo S., Choi S., Lee J., Cho S., Park J., Kim J., Lee E., Kim J., Kim S., Kim U., COVID-19 National Emergency Response Center, Epidemiology and Case Management Team, Korea Centers for Disease Control and Prevention",57215653219;57215675940;57215655960;37960940600;57215660412;57215663460;57189320800;57201935846;57216094460;57215673768;57215651037;57215650293;57215672295;57215671496;57215676048;57215672509;57215787140;57215660589;57215656286;57215662004;57215653315;57215664149;57215654427;57215662215;57215658420;57215672539;57215655113;57215657653;57215675965;57215675871;57215658986;57200805599;57215655179;57215661828;57192500755;57215653993;57215676040;57215661973;57215673722;57215666914;57202962618;57215676085;57215663756;57215667186;55897086800;57215664217;57215663590;57215663293;57215666409;57215655806;57215652122;57215656049;57215663699;57215675773;57206478698;57215671486;57215670776;57215652110;57215676089;57215658465;57215661934;57215676044;57215669607;57215675916;57215675962;57215664441;,Early epidemiological and clinical characteristics of 28 cases of coronavirus disease in South Korea,2020,Osong Public Health and Research Perspectives,,1,,8,14,,1,10.24171/j.phrp.2020.11.1.03,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081562008&doi=10.24171%2fj.phrp.2020.11.1.03&partnerID=40&md5=4fbff505b99a3dc931cb6ac90b3ebe28,"Center for Disease Prevention, KCDC, South Korea; Center for Infectious Disease Control, KCDC, South Korea; Center for Public Health Emergency Preparedness and Response, KCDC, South Korea; Center for Laboratory Control of Infectious Diseases, KCDC, South Korea; Center for Genome Science, KCDC, South Korea; Center for Organ Transplant Management, KCDC, South Korea; National Center for Medical Information and Knowledge, KCDC, South Korea; Bureau of Planning and Coordination, KCDC, South Korea; Bureau of Health Policy, Ministry of Health and Welfare, MOHW, Taiwan","Kong, I., Center for Disease Prevention, KCDC, South Korea; Park, Y., Center for Disease Prevention, KCDC, South Korea; Woo, Y., Center for Disease Prevention, KCDC, South Korea; Lee, J., Center for Disease Prevention, KCDC, South Korea; Cha, J., Center for Disease Prevention, KCDC, South Korea; Choi, J., Center for Disease Prevention, KCDC, South Korea; Kim, Y., Center for Disease Prevention, KCDC, South Korea; Kim, J., Center for Disease Prevention, KCDC, South Korea; Park, S., Center for Disease Prevention, KCDC, South Korea; Yum, M., Center for Disease Prevention, KCDC, South Korea; Kim, T., Center for Disease Prevention, KCDC, South Korea; Jo, J., Center for Disease Prevention, KCDC, South Korea; Kim, M., Center for Infectious Disease Control, KCDC, South Korea; Lee, D., Center for Infectious Disease Control, KCDC, South Korea; Kim, J., Center for Infectious Disease Control, KCDC, South Korea; Park, S., Center for Infectious Disease Control, KCDC, South Korea; Bahk, H., Center for Infectious Disease Control, KCDC, South Korea; Yu, J., Center for Infectious Disease Control, KCDC, South Korea; Kwon, J., Center for Infectious Disease Control, KCDC, South Korea; Kim, H., Center for Infectious Disease Control, KCDC, South Korea; Shin, N., Center for Infectious Disease Control, KCDC, South Korea; Lee, S., Center for Infectious Disease Control, KCDC, South Korea; In, H., Center for Infectious Disease Control, KCDC, South Korea; Jung, J., Center for Infectious Disease Control, KCDC, South Korea; Cho, S., Center for Infectious Disease Control, KCDC, South Korea; Jeon, B., Center for Infectious Disease Control, KCDC, South Korea; Kim, D., Center for Infectious Disease Control, KCDC, South Korea; Jin, G., Center for Public Health Emergency Preparedness and Response, KCDC, South Korea; Kim, S., Center for Public Health Emergency Preparedness and Response, KCDC, South Korea; Kim, S., Center for Public Health Emergency Preparedness and Response, KCDC, South Korea; Kim, Y., Center for Public Health Emergency Preparedness and Response, KCDC, South Korea; Kim, E., Center for Public Health Emergency Preparedness and Response, KCDC, South Korea; Kim, B.I., Center for Public Health Emergency Preparedness and Response, KCDC, South Korea; Kim, H., Center for Public Health Emergency Preparedness and Response, KCDC, South Korea; Lee, H., Center for Public Health Emergency Preparedness and Response, KCDC, South Korea; Jin, Y., Center for Public Health Emergency Preparedness and Response, KCDC, South Korea; Kim, J., Center for Public Health Emergency Preparedness and Response, KCDC, South Korea; Kim, H., Center for Public Health Emergency Preparedness and Response, KCDC, South Korea; Ryu, B., Center for Public Health Emergency Preparedness and Response, KCDC, South Korea; Shin, S., Center for Public Health Emergency Preparedness and Response, KCDC, South Korea; Shin, E., Center for Public Health Emergency Preparedness and Response, KCDC, South Korea; Lee, J., Center for Public Health Emergency Preparedness and Response, KCDC, South Korea; Lee, S., Center for Public Health Emergency Preparedness and Response, KCDC, South Korea; Jang, Y., Center for Public Health Emergency Preparedness and Response, KCDC, South Korea; Choi, E., Center for Public Health Emergency Preparedness and Response, KCDC, South Korea; Hyun, J., Center for Public Health Emergency Preparedness and Response, KCDC, South Korea; Ko, D., Center for Public Health Emergency Preparedness and Response, KCDC, South Korea; Seo, G., Center for Public Health Emergency Preparedness and Response, KCDC, South Korea; Kwon, S., Center for Public Health Emergency Preparedness and Response, KCDC, South Korea; Park, E., Center for Public Health Emergency Preparedness and Response, KCDC, South Korea; Choi, S., Center for Public Health Emergency Preparedness and Response, KCDC, South Korea; Hwang, S., Center for Laboratory Control of Infectious Diseases, KCDC, South Korea; Lee, S., Center for Laboratory Control of Infectious Diseases, KCDC, South Korea; Kang, B., Center for Laboratory Control of Infectious Diseases, KCDC, South Korea; Park, J., Center for Laboratory Control of Infectious Diseases, KCDC, South Korea; Lee, D., Center for Laboratory Control of Infectious Diseases, KCDC, South Korea; Jo, S., Center for Laboratory Control of Infectious Diseases, KCDC, South Korea; Choi, S., Center for Laboratory Control of Infectious Diseases, KCDC, South Korea; Lee, J., Center for Genome Science, KCDC, South Korea; Cho, S., Center for Genome Science, KCDC, South Korea; Park, J., Center for Genome Science, KCDC, South Korea; Kim, J., Center for Organ Transplant Management, KCDC, South Korea; Lee, E., National Center for Medical Information and Knowledge, KCDC, South Korea; Kim, J., National Center for Medical Information and Knowledge, KCDC, South Korea; Kim, S., Bureau of Planning and Coordination, KCDC, South Korea; Kim, U., Bureau of Health Policy, Ministry of Health and Welfare, MOHW, Taiwan; COVID-19 National Emergency Response Center, Epidemiology and Case Management Team, Korea Centers for Disease Control and Prevention","Objectives: The first confirmed case of coronavirus disease 2019 (COVID-19) in South Korea was reported in January 2020, with 28 confirmed cases reported as of February 14th, 2020. The epidemiological and clinical characteristics of all 28 cases were analyzed in response to this disease. Methods: The epidemiological characteristics and early clinical features of the 28 patients from Korea with confirmed COVID-19 were analyzed using COVID-19 reporting and surveillance data and the epidemiological investigation reports prepared by the rapid response team. Results: There were 16 patients that entered Korea from foreign countries: Wuhan, China (11 patients), Zhuhai, China, (1 patient), Singapore (2 patients), Japan (1 patient), and Thailand (1 patient). The early symptoms were fever, sore throat, cough or sputum production, chills, and muscle ache. Three patients were asymptomatic, however, 18 developed pneumonia. Of the 28 cases, 16 were index cases imported from abroad, with 10 cases of secondary infection originating in Korea, and the route of transmission still under investigation for 2 patients. The 10 patients with secondary infection were infected from contact with family members or acquaintances of primary patients, and the suspected sites of transmission were mostly at home. Conclusion: COVID-19 in Korea was spread by 16 infected individuals traveling from other countries, leading to second-generation cases. The initial symptoms were mostly minor, but the disease was infectious at this stage, resulting from close contact, particularly at home. Establishing an early detection strategy for COVID-19 is crucial for managing the transmission of the disease. © 2020 Korea Centers for Disease Control and Prevention.",COVID-19; Epidemiologic study; SARS-CoV-2,analgesic agent; antibiotic agent; adult; aged; Article; asymptomatic infection; case study; chill; China; clinical article; clinical feature; coronavirus disease 2019; Coronavirus infection; coughing; family; female; fever; headache; home; human; Japan; male; middle aged; myalgia; priority journal; secondary infection; Singapore; sore throat; South Korea; sputum; Thailand; travel; virus pneumonia; virus transmission; weakness,"Coronavirus Disease (COVID-19): Situation Reports, , https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports, Internet. Geneva (Switzerland); World Health Organization: 2020 cited 2020 Feb 17; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study (2020) Lancet, 395, pp. 507-513. , 10223; COVID-19: Health Alerts, the Fastest Updates, , http://ncov.mohw.go.kr/tcmBoardList.do?brdId=&brdGubun=&dataGubun=&ncvContSeq=&contSeq=&board_id=, Korea Centers for Disease Control and Prevention Internet. Cheongju (Korea); Korea Centers for Disease Control and Prevention: 2020 cited 2020 Feb 14; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506. , 10223; Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) New Engl J Med, , Epub 2020 Jan 29. Epub ahead of print",,,Korea Centers for Disease Control and Prevention,22109099,,,,English,Osong Public Health Res. Perspect.,Article,Final,Open Access,Scopus,2-s2.0-85081562008,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Tian X., Li C., Huang A., Xia S., Lu S., Shi Z., Lu L., Jiang S., Yang Z., Wu Y., Ying T.",57215621926;57214940255;57197719521;56410369000;57214932518;7403733955;55715616400;56491898300;57211577437;57191872979;57205480302;,Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody,2020,Emerging Microbes and Infections,9,1,,382,385,,12,10.1080/22221751.2020.1729069,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079515414&doi=10.1080%2f22221751.2020.1729069&partnerID=40&md5=8b21752fa2518ce267adba5ee3790c3b,"MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China; CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China","Tian, X., MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China; Li, C., MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China; Huang, A., MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China; Xia, S., MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China; Lu, S., MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China; Shi, Z., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Lu, L., MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China; Jiang, S., MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China; Yang, Z., Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China; Wu, Y., MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China; Ying, T., MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China","The newly identified 2019 novel coronavirus (2019-nCoV) has caused more than 11,900 laboratory-confirmed human infections, including 259 deaths, posing a serious threat to human health. Currently, however, there is no specific antiviral treatment or vaccine. Considering the relatively high identity of receptor-binding domain (RBD) in 2019-nCoV and SARS-CoV, it is urgent to assess the cross-reactivity of anti-SARS CoV antibodies with 2019-nCoV spike protein, which could have important implications for rapid development of vaccines and therapeutic antibodies against 2019-nCoV. Here, we report for the first time that a SARS-CoV-specific human monoclonal antibody, CR3022, could bind potently with 2019-nCoV RBD (KD of 6.3 nM). The epitope of CR3022 does not overlap with the ACE2 binding site within 2019-nCoV RBD. These results suggest that CR3022 may have the potential to be developed as candidate therapeutics, alone or in combination with other neutralizing antibodies, for the prevention and treatment of 2019-nCoV infections. Interestingly, some of the most potent SARS-CoV-specific neutralizing antibodies (e.g. m396, CR3014) that target the ACE2 binding site of SARS-CoV failed to bind 2019-nCoV spike protein, implying that the difference in the RBD of SARS-CoV and 2019-nCoV has a critical impact for the cross-reactivity of neutralizing antibodies, and that it is still necessary to develop novel monoclonal antibodies that could bind specifically to 2019-nCoV RBD. © 2020, © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd.",2019-nCoV; ACE2; monoclonal antibody; RBD; SARS-CoV,"angiotensin converting enzyme 2; arginine; asparagine; epitope; human monoclonal antibody; lysine; m396 antibody; monoclonal antibody CR3022; neutralizing antibody; unclassified drug; valine; virus antibody; virus glycoprotein; virus spike protein; virus vaccine; coronavirus spike glycoprotein; COVID-19; monoclonal antibody; severe acute respiratory syndrome coronavirus 2; virus antibody; 2019 novel coronavirus; amino acid sequence; antibody specificity; binding affinity; binding competition; carboxy terminal sequence; competitive binding assay; controlled study; Coronavirinae; cross reaction; drug binding site; drug potency; drug receptor binding; enzyme linked immunosorbent assay; human; hydrogen bond; interferometry; Letter; nonhuman; phylogeny; priority journal; protein conformation; protein purification; SARS coronavirus; Betacoronavirus; Coronavirus infection; cross reaction; immunology; protein tertiary structure; SARS coronavirus; virus pneumonia; Amino Acid Sequence; Antibodies, Monoclonal; Antibodies, Viral; Betacoronavirus; Coronavirus Infections; Cross Reactions; Humans; Pneumonia, Viral; Protein Structure, Tertiary; SARS Virus; Spike Glycoprotein, Coronavirus","Chan, J.F., Kok, K.H., Zhu, Z., Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan (2020) Emerg Microbes Infect, 9 (1), pp. 221-236; Zhou, P., Yang, X.L., Wang, X.G., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature, , https://doi.org/10.1038/s41586-020-2012-7, [Epub ahead of print]; Zhu, Z., Chakraborti, S., He, Y., Potent cross-reactive neutralization of SARS coronavirus isolates by human monoclonal antibodies (2007) Proc Natl Acad Sci USA, 104 (29), pp. 12123-12128; ter Meulen, J., Bakker, A.B.H., van den Brink, E.N., Human monoclonal antibody as prophylaxis for SARS coronavirus infection in ferrets (2004) The Lancet, 363 (9427), pp. 2139-2141; ter Meulen, J., Van Den Brink, E.N., Poon, L.L.M., Human monoclonal antibody combination against SARS coronavirus: synergy and coverage of escape mutants (2006) PLoS Med, 3 (7), p. e237; Sui, J., Li, W., Murakami, A., Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association (2004) Proc Natl Acad Sci USA, 101 (8), pp. 2536-2541; Traggiai, E., Becker, S., Subbarao, K., An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus (2004) Nat Med, 10 (8), pp. 871-875; Gallagher, T.M., Buchmeier, M.J., Coronavirus spike proteins in viral entry and pathogenesis (2001) Virology, 279 (2), pp. 371-374; Wong, S.K., Li, W., Moore, M.J., A 193-amino acid fragment of the SARS coronavirus S protein efficiently binds angiotensin-converting enzyme 2 (2004) J Biol Chem, 279 (5), pp. 3197-3201; Prabakaran, P., Gan, J., Feng, Y., Structure of severe acute respiratory syndrome coronavirus receptor-binding domain complexed with neutralizing antibody (2006) J Biol Chem, 281 (23), pp. 15829-15836; Pak, J.E., Sharon, C., Satkunarajah, M., Structural insights into immune recognition of the severe acute respiratory syndrome coronavirus S protein receptor binding domain (2009) J Mol Biol, 388 (4), pp. 815-823; Hwang, W.C., Lin, Y., Santelli, E., Structural basis of neutralization by a human anti-severe acute respiratory syndrome spike protein antibody, 80R (2006) J Biol Chem, 281 (45), pp. 34610-34616; Li, F., Li, W., Farzan, M., Structure of SARS coronavirus spike receptor-binding domain complexed with receptor (2005) Science, 309 (5742), pp. 1864-1868; Walls, A.C., Xiong, X., Park, Y.-J., Unexpected receptor functional mimicry elucidates activation of coronavirus fusion (2019) Cell, 176 (5), pp. 1026-1039; Ying, T., Prabakaran, P., Du, L., Junctional and allele-specific residues are critical for MERS-CoV neutralization by an exceptionally potent germline-like antibody (2015) Nat Commun, 6, p. 8223","Wu, Y.Fosun Building, 131 Dong-an Road, China; email: yanlingwu@fudan.edu.cn",,Taylor and Francis Ltd.,22221751,,,32065055,English,Emerg. Microbes Infect.,Letter,Final,Open Access,Scopus,2-s2.0-85079515414,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Li K., McCray P.B., Jr.",56095990000;7007180790;,Development of a mouse-adapted MERS coronavirus,2020,Methods in Molecular Biology,2099,,,161,171,,,10.1007/978-1-0716-0211-9_13,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077323635&doi=10.1007%2f978-1-0716-0211-9_13&partnerID=40&md5=6e18896cf39e63fa1a8a17ef796f15e4,"Department of Pediatrics, Pappajohn Biomedical Institute, University of Iowa, Iowa City, IA, United States; Department of Microbiology, University of Iowa, Iowa City, IA, United States","Li, K., Department of Pediatrics, Pappajohn Biomedical Institute, University of Iowa, Iowa City, IA, United States; McCray, P.B., Jr., Department of Pediatrics, Pappajohn Biomedical Institute, University of Iowa, Iowa City, IA, United States, Department of Microbiology, University of Iowa, Iowa City, IA, United States","First identified in 2012, Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel virus that can cause acute respiratory distress syndrome (ARDS), multiorgan failure, and death, with a case fatality rate of ~35%. An animal model that supports MERS-CoV infection and causes severe lung disease is useful to study pathogenesis and evaluate therapies and vaccines. The murine dipeptidyl peptidase 4 (Dpp4) protein is not a functional receptor for MERS-CoV; thus, mice are resistant to MERS-CoV infection. We generated human DPP4 knock-in (hDPP4 KI) mice by replacing exons 10–12 at the mouse Dpp4 locus with exons 10–12 from the human DPP4 gene. The resultant human DPP4 KI mice are permissive to MERS-CoV (HCoV-EMC/2012 strain) infection but develop no disease. To generate a mouse model with associated morbidity and mortality from respiratory disease, we serially passaged HCoV-EMC/2012 strain in the lungs of young hDPP4 KI mice. After 30 in vivo passages, an adapted virus clone was isolated and designated MERSMA6.1.2. This virus clone produced significantly higher titers than the parental clone in the lungs of hDPP4 KI mice and caused diffuse lung injury and a fatal respiratory infection. In this chapter, we will describe in detail the procedures used to mouse adapt MERS-CoV by serial passage of the virus in lungs. We also describe the methods used to isolate virus clones and characterize virus infection. © Springer Science+Business Media, LLC, part of Springer Nature 2020.",Mouse model; Mouse-adapted virus; Serial passage; Virus clone isolation,,"Zaki, A.M., Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia (2012) N Engl J Med, 367 (19), pp. 1814-1820; Raj, V.S., Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC (2013) Nature, 495 (7440), pp. 251-254; Breban, R., Riou, J., Fontanet, A., Interhu-man transmissibility of Middle East respiratory syndrome coronavirus: Estimation of pandemic risk (2013) Lancet, 382 (9893), pp. 694-699; Perlman, S., McCray, P.B., Jr., Person-to-person spread of the MERS coronavirus-an evolving picture (2013) N Engl J Med, 369 (5), pp. 466-467; Kucharski, A.J., Althaus, C.L., The role of superspreading in Middle East respiratory syndrome coronavirus (MERS-CoV) transmission (2015) Euro Surveill, 20 (25), pp. 14-18; Hui, D.S., Perlman, S., Zumla, A., Spread of MERS to South Korea and China (2015) Lancet Respir Med, 3 (7), pp. 509-510; Zumla, A., Infectious diseases epidemic threats and mass gatherings: Refocusing global attention on the continuing spread of the Middle East respiratory syndrome coronavirus (MERS-CoV) (2016) BMC Med, 14 (1); Chen, X., Comparative epidemiology of Middle East respiratory syndrome coronavirus (MERS-CoV) in Saudi Arabia and South Korea (2017) Emerg Microbes Infect, 6 (6); Ng, D.L., Clinicopathologic, immu-nohistochemical, and ultrastructural findings of a fatal case of Middle East respiratory syndrome coronavirus infection in the United Arab Emirates, April 2014 (2016) Am J Pathol, 186 (3), pp. 652-658; Alsaad, K.O., Histopathology of Middle East respiratory syndrome coronovirus (MERS-CoV) infection-clinicopathological and ultrastructural study (2018) Histopathology, 72 (3), pp. 516-524; de Wit, E., Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques (2013) Proc Natl Acad Sci U S A, 110 (41), pp. 16598-16603; Yao, Y., An animal model of MERS produced by infection of rhesus macaques with MERS coronavirus (2014) J Infect Dis, 209 (2), pp. 236-242; Prescott, J., Pathogenicity and viral shedding of MERS-CoV in immunocompro-mised rhesus macaques (2018) Front Immunol, 9, p. 205; Johnson, R.F., Intratracheal exposure of common marmosets to MERS-CoV Jordan-n3/2012 or MERS-CoV EMC/2012 isolates does not result in lethal disease (2015) Virology, 485, pp. 422-430; Falzarano, D., Infection with MERS-CoV causes lethal pneumonia in the common marmoset (2014) Plos Pathog, 10 (8); Cockrell, A.S., Mouse dipeptidyl peptidase 4 is not a functional receptor for Middle East respiratory syndrome coronavirus infection (2014) J Virol, 88 (9), pp. 5195-5199; Coleman, C.M., Wild-type and innate immune-deficient mice are not susceptible to the Middle East respiratory syndrome coronavirus (2014) J Gen Virol, 95, pp. 408-412; Raj, V.S., Adenosine deaminase acts as a natural antagonist for dipeptidyl peptidase 4-mediated entry of the Middle East respiratory syndrome coronavirus (2014) J Virol, 88 (3), pp. 1834-1838; de Wit, E., Domestic pig unlikely reservoir for MERS-CoV (2017) Emerg Infect Dis, 23 (6), pp. 985-988; de Wit, E., The Middle East respiratory syndrome coronavirus (MERS-CoV) does not replicate in Syrian hamsters (2013) Plos One, 8 (7); van Doremalen, N., Host species restriction of Middle East respiratory syndrome coronavirus through its receptor, dipeptidyl peptidase 4 (2014) J Virol, 88 (16), pp. 9220-9232; Barlan, A., Receptor variation and susceptibility to Middle East respiratory syndrome coronavirus infection (2014) J Virol, 88 (9), pp. 4953-4961; Haagmans, B.L., Asymptomatic Middle East respiratory syndrome coronavirus infection in rabbits (2015) J Virol, 89 (11), pp. 6131-6135; Zhao, J., Rapid generation of a mouse model for Middle East respiratory syndrome (2014) Proc Natl Acad Sci U S A, 111 (13), pp. 4970-4975; Agrawal, A.S., Generation of a transgenic mouse model of Middle East respiratory syndrome coronavirus infection and disease (2015) J Virol, 89 (7), pp. 3659-3670; Li, K., Middle East respiratory syndrome coronavirus causes multiple organ damage and lethal disease in mice transgenic for human dipeptidyl peptidase 4 (2016) J Infect Dis, 213 (5), pp. 712-722; Zhao, G., Multi-organ damage in human dipeptidyl peptidase 4 transgenic mice infected with Middle East respiratory syndrome-coronavirus (2015) Plos One, 10 (12); Fan, C., A human DPP4-knockin mouse’s susceptibility to infection by authentic and pseudotyped MERS-CoV (2018) Viruses, 10 (9), p. E448; McCray, P.B., Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus (2007) J Virol, 81 (2), pp. 813-821; Pascal, K.E., Pre-and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection (2015) Proc Natl Acad Sci U S A, 112 (28), pp. 8738-8743; Coleman, C.M., CD8+ T cells and macrophages regulate pathogenesis in a mouse model of Middle East respiratory syndrome (2017) J Virol, 91 (1); Cockrell, A.S., A mouse model for MERS coronavirus-induced acute respiratory distress syndrome (2016) Nat Microbiol, 2, p. 16226; Li, K., Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice (2017) Proc Natl Acad Sci U S A, 114 (15), pp. E3119-E3128; Roberts, A., A mouse-adapted SARS-coronavirus causes disease and mortality in BALB/c mice (2007) Plos Pathog, 3 (1), p. e5; Day, C.W., A new mouse-adapted strain of SARS-CoV as a lethal model for evaluating antiviral agents in vitro and in vivo (2009) Virology, 395 (2), pp. 210-222; Frieman, M., Molecular determinants of severe acute respiratory syndrome coronavirus pathogenesis and virulence in young and aged mouse models of human disease (2012) J Virol, 86 (2), pp. 884-897","McCray, P.B.; Department of Microbiology, University of IowaUnited States; email: paul-mccray@uiowa.edu",,Humana Press Inc.,10643745,,,31883095,English,Methods Mol. Biol.,Book Chapter,Final,Open Access,Scopus,2-s2.0-85077323635,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Singh S., Singh R., Singh K.P., Singh V., Malik Y.P.S., Kamdi B., Singh R., Kashyap G.",57208600128;57207895915;35387019900;16687007500;55407524100;57192254353;55574239628;57198421784;,Immunohistochemical and molecular detection of natural cases of bovine rotavirus and coronavirus infection causing enteritis in dairy calves,2020,Microbial Pathogenesis,138,,103814,,,,,10.1016/j.micpath.2019.103814,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85073836329&doi=10.1016%2fj.micpath.2019.103814&partnerID=40&md5=71a557ab14611024cdf51e0c279bcbdd,"Division of Pathology, ICAR-Indian Veterinary Research Institute, IzatnagarUP 243 122, India; Division of Biological Standardization, ICAR-Indian Veterinary Research Institute, IzatnagarUP 243 122, India","Singh, S., Division of Pathology, ICAR-Indian Veterinary Research Institute, IzatnagarUP 243 122, India; Singh, R., Division of Pathology, ICAR-Indian Veterinary Research Institute, IzatnagarUP 243 122, India; Singh, K.P., Division of Pathology, ICAR-Indian Veterinary Research Institute, IzatnagarUP 243 122, India; Singh, V., Division of Pathology, ICAR-Indian Veterinary Research Institute, IzatnagarUP 243 122, India; Malik, Y.P.S., Division of Biological Standardization, ICAR-Indian Veterinary Research Institute, IzatnagarUP 243 122, India; Kamdi, B., Division of Pathology, ICAR-Indian Veterinary Research Institute, IzatnagarUP 243 122, India; Singh, R., Division of Pathology, ICAR-Indian Veterinary Research Institute, IzatnagarUP 243 122, India; Kashyap, G., Division of Pathology, ICAR-Indian Veterinary Research Institute, IzatnagarUP 243 122, India","Bovine rotavirus (BRoV) and bovine coronavirus (BCoV) are major enteric viral pathogens responsible for calve diarrhoea. They are widespread both in dairy and beef cattle throughout the world and causing huge economic losses. The diagnosis of these agents is very difficult due to non-specific nature of lesions and the involvement of some intrinsic and extrinsic risk factors. We performed postmortem of 45 calves, which was below three months of age. Out of 45 necropscid calves, three (6.66%) cases were positive for BRoV and four (8.88%) cases were found positive for BCoV, screened by reverse transcriptase polymerase chain reaction (RT-PCR). Further RT-PCR positive cases were confirmed by immunohistochemistry (IHC) in paraffin-embedded intestinal tissue sections. Three cases of enteritis caused by BRoV showed the hallmark lesions of the shortening and fusion of villi, denudation and infiltration of mononuclear cells in the lamina propria. The BRoV antigen distribution was prominent within the lining epithelium of the villi, peyer's patches in the ileum and strong immunoreactions in the lymphocytes and some macrophages of the mesenteric lymph nodes. Four cases in which BCoV was detected, grossly lesions characterized by colonic mucosa covered with thick, fibrinous and diphtheritic membrane. Histopathologically, jejunum showed skipping lesion of micro-abscesses in crypts. The BCoV antigen distribution was prominent within the necrotic crypts in the jejunum and cryptic micro-abscesses in the colon and ileum. It is the first report of BRoV and BCoV antigen demonstration in the jejunum, colon, ileum, Peyer's patches and mesenteric lymph nodes of naturally infected calves from India by using IHC. © 2019",Coronavirus; Immunohistochemistory; Rotavirus; RT-PCR,animal tissue; antigen detection; Article; Bovine rotavirus A; controlled study; Coronavirinae; Coronavirus infection; dairy cattle; enteritis; histopathology; immunohistochemistry; intestine tissue; intestine villus; lamina propria; lymphocyte; macrophage; mesentery lymph node; molecular diagnosis; mononuclear cell; nonhuman; Peyer patch; priority journal; reverse transcription polymerase chain reaction; Rotavirus infection; virus identification,"Razzaque, M.A., Bedair, M., Abbas, S., Performance of pre-weaned female calves confined in housing and open environment hutches in Kuwait (2009) Pak. Vet. J., 29, pp. 1-4; Part II: Changes in the U.S. Dairy Cattle Industry, 1991-2007 (2007), pp. 57-61. , USDA-APHIS-VS, CEAH Fort Collins 2008; Cho, Y.I., Yoon, K.J., An overview of calf diarrhea-infectious etiology, diagnosis, and intervention (2014) J. Vet. Sci., 15 (1), pp. 1-17; Dhama, K., Chauhan, R.S., Mahendran, M., Malik, S.V.S., Rotavirus diarrhea in bovines and other domestic animals (2009) Vet. Res. Commun., 33 (1), pp. 1-23; Gumusova, S.O., Yazici, Z., Albayrak, H., Meral, Y., Rotavirus and coronavirus prevalence in healthy calves and calves with diarrhea (2007) Med. Vet., 63, pp. 62-64; Malik, S.V.S., Barbuddhe, S.B., Rawool, D.B., Vaidya, V.M., Sahare, A.M., Data Sheet on Rotaviruses (Global Status of Rotavirus Infections in Man and Animals). Animal Health and Production Compendium (2005), CAB International Wallingford, UK; Singh, S., Singh, R., Kamdi, B.P., Kasyap, G., Singh, R., George, N., Kumar, P., Singh, V., Occurrence and pathology of cryptosporidium in bovine calves of North and Central India (2018) J. Anim. Res., 8 (5), p. 925; Kashyap, G., Singh, R., Malik, Y.S., Agrawal, R.K., Singh, K.P., Kumar, P., Singh, R., Gupta, D., Rotavirus A associated pathology of intestine and mesenteric lymph nodes and occurrence in bovine calves of Gwalior and Bareilly regions (2018) Indian J. Anim. Res., 52 (1), pp. 99-104; Uhde, F.L., Kaufmann, T., Sager, H., Albini, S., Zanoni, R., Schelling, E., Meylan, M., Prevalence of four enteropathogens in the faeces of young diarrhoeic dairy calves in Switzerland (2008) Vet. Rec., 163 (12), pp. 362-366; Boileau, M.J., Kapil, S., Bovine coronavirus associated syndromes (2010) Vet. Clin. N. Am., 26 (1), pp. 123-146; Barry, A.F., Alfieri, A.F., Stipp, D.T., Alfieri, A.A., Bovine coronavirus detection in a collection of diarrheic stool samples positive for group a bovine rotavirus (2009) Braz. Arch. Biol. Technol., 52, pp. 45-49; Gay, C.C., Hodgson, J.C., Lofstedt, J., Boli, N.S.R., Diarrhoea in Neonatal Ruminants: Intestinal Diseases in Ruminants: Merck Veterinary Manual (2012), http://www.merckmanuals.com/vet/print/digestive_system/intestinal_diseases_in_ruminants/diarrhea_in_neonatal_ruminants.html, [online]available from:; Athanassious, R., Marsolais, G., Assaf, R., Dea, S., Descoteaux, J.P., Dulude, S., Montpetit, C., Detection of bovine coronavirus and type A rotavirus in neonatal calf diarrhea and winter dysentery of cattle in Quebec: evaluation of three diagnostic methods (1994) Can. Vet. J., 35 (3), pp. 163-169; Ramig, R.F., Pathogenesis of intestinal and systemic rotavirus infection (2004) J. Virol., 78, pp. 10213-10220; Schultze, B., Gross, H.J., Brossmer, R., Herrler, G., The S protein of bovine coronavirus is a hemagglutinin recognizing 9-O-acetylated sialic acid as a receptor determinant (1991) J. Virol., 65, pp. 6232-6237; Jubb, K., Palmers, (2007) Patholoy of Domestic Animals, 1, pp. 546-550; Mondal, A., Sharma, K., Malik, Y.S., Joardar, S.N., Detection of group a rotavirus in faeces of diarrhoeic bovine porcine and human population from eastern India by reverse transcriptase–polymerase chain reaction (2013) Adv. Anim. Vet. Sci., 1 (1S), pp. 18-19; Luna, L.G., Histological Staining Methods of the Armed Forces Institute of Pathology (1972), pp. 32-37. , 3 edn. McGraw Hill Book Co. 12-17 New York 159; McGavin, M.D., Zachary, J.F., Pathological Basis of Veterinary Disease (2007), fourth ed. Mosby Elsevier St. Louise, Missouri; Bellinzoni, R.C., Mattion, N.M., Burrone, O., Gonzalez, A., La Torre, J.L., Scodeller, E.A., Isolation of group A swine rotaviruses displaying atypical electropherotypes (1987) J. Clin. Microbiol., 25 (5), pp. 952-954; Dash, S.K., Tewari, A., Kumar, K., Goel, A., Bhatia, A.K., Detection of Rotavirus from diarrhoeic cow calves in Mathura, India (2011) Vet. World, 4 (12), pp. 554-556; Radostits, O.M., Gay, C.C., Hinchcliff, K.W., Constable, P.D., Veterinary Medicine (2007), tenth ed. Saunders Philadelphia; Windeyer, M.C., Leslie, K.E., Godden, S.M., Hodgins, D.C., Lissemore, K.D., LeBlanc, S.J., The effects of viral vaccination of dairy heifer calves on the incidence of respiratory disease, mortality, and growth (2012) J. Dairy Sci., 95 (11), pp. 6731-6739; Chauhan, R.S., Dhama, K., Mahendran, M., Pathobiology of rotaviral diarrhea in calves and its diagnosis and control: a review (2008) J. Immunol. Immunopathol., 10 (1), pp. 1-13; Gruenberg, W., Diarrhoea in neonatal ruminants (2014) The Merck Veterinary Manual, , C. Kahn S. L (Whitehouse Station, NJ, USA); Reynolds, D.J., Hall, G.A., Debney, T.G., Bunch, K.J., Parsons, K.R., Pathology of natural rotavirus infection in clinically normal calves (1985) Res. Vet. Sci., 38, pp. 264-269; Kashyap, G., Singh, R., Malik, Y.S., Agrawal, R.K., Singh, K.P., Kumar, P., Sahoo, M., Singh, R., Experimental bovine rotavirus-A (RV-A) infection causes intestinal and extra-intestinal pathology in suckling mice (2018) Microb. Pathog., 121, pp. 22-26; Kim, H.J., Park, J.G., Matthijnssens, J., Lee, J.H., Bae, Y.C., Alfajaro, M.M., Park, S.I., Cho, K.O., Intestinal and extra-intestinal pathogenicity of a bovine reassortant rotavirus in calves and piglets (2011) Vet. Microbiol., 152 (3-4), pp. 291-303; Crawford, S.E., Patel, D.G., Cheng, E., Berkova, Z., Hyser, J.M., Ciarlet, M., Finegold, M.J., Estes, M.K., Rotavirus viremia and extraintestinal viral infection in the neonatal Rat model (2006) J. Virol., 80 (10), pp. 4820-4832; Park, S.J., Kim, G.Y., Choy, H.E., Hong, Y.J., Saif, L.J., Jeong, J.H., Park, S.I., Kang, M.I., Dual enteric and respiratory tropisms of winter dysentery bovine coronavirus in calves (2007) Arch. Virol., 152 (10), pp. 1885-1900; Field, P.M., Newsletter, A.H.L., Bovine coronavirus (BCoV) and rotavirus (BRV) – on the increase? (2015) AHL Newsl., 19, p. 3","Singh, R.; Principal Scientist and Ex-Head, Division of Pathology, Indian Veterinary Research Institute, Izatnagar, India; email: rajendra_singh5747@rediffmail.com",,Academic Press,8824010,,MIPAE,31639467,English,Microb. Pathog.,Article,Final,Open Access,Scopus,2-s2.0-85073836329,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Yuan M., Yin W., Tao Z., Tan W., Hu Y.",55017902400;57214756133;57215653821;57215847019;57194116845;,"Association of radiologic findings with mortality of patients infected with 2019 novel coronavirus in Wuhan, China",2020,PLoS ONE,15,3, e0230548,,,,,10.1371/journal.pone.0230548,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082082571&doi=10.1371%2fjournal.pone.0230548&partnerID=40&md5=b882bb1df1ae213749d7c2aabdb19574,"Department of Pulmonary and Critical Care Medicine, Huazhong University of Science and Technology, Central Hospital of Wuhan, Wuhan, Hubei, China","Yuan, M., Department of Pulmonary and Critical Care Medicine, Huazhong University of Science and Technology, Central Hospital of Wuhan, Wuhan, Hubei, China; Yin, W., Department of Pulmonary and Critical Care Medicine, Huazhong University of Science and Technology, Central Hospital of Wuhan, Wuhan, Hubei, China; Tao, Z., Department of Pulmonary and Critical Care Medicine, Huazhong University of Science and Technology, Central Hospital of Wuhan, Wuhan, Hubei, China; Tan, W., Department of Pulmonary and Critical Care Medicine, Huazhong University of Science and Technology, Central Hospital of Wuhan, Wuhan, Hubei, China; Hu, Y., Department of Pulmonary and Critical Care Medicine, Huazhong University of Science and Technology, Central Hospital of Wuhan, Wuhan, Hubei, China","Radiologic characteristics of 2019 novel coronavirus (2019-nCoV) infected pneumonia (NCIP) which had not been fully understood are especially important for diagnosing and predicting prognosis. We retrospective studied 27 consecutive patients who were confirmed NCIP, the clinical characteristics and CT image findings were collected, and the association of radiologic findings with mortality of patients was evaluated. 27 patients included 12 men and 15 women, with median age of 60 years (IQR 47-69). 17 patients discharged in recovered condition and 10 patients died in hospital. The median age of mortality group was higher compared to survival group (68 (IQR 63-73) vs 55 (IQR 35-60), P = 0.003). The comorbidity rate in mortality group was significantly higher than in survival group (80% vs 29%, P = 0.018). The predominant CT characteristics consisted of ground glass opacity (67%), bilateral sides involved (86%), both peripheral and central distribution (74%), and lower zone involvement (96%). The median CT score of mortality group was higher compared to survival group (30 (IQR 7-13) vs 12 (IQR 11-43), P = 0.021), with more frequency of consolidation (40% vs 6%, P = 0.047) and air bronchogram (60% vs 12%, P = 0.025). An optimal cutoff value of a CT score of 24.5 had a sensitivity of 85.6% and a specificity of 84.5% for the prediction of mortality. 2019-nCoV was more likely to infect elderly people with chronic comorbidities. CT findings of NCIP were featured by predominant ground glass opacities mixed with consolidations, mainly peripheral or combined peripheral and central distributions, bilateral and lower lung zones being mostly involved. A simple CT scoring method was capable to predict mortality. © 2020 Public Library of Science. All rights reserved.",,"adult; aged; Article; bronchography; China; clinical article; clinical feature; comorbidity; computer assisted tomography; Coronavirus disease 2019; Coronavirus infection; female; human; male; mortality rate; prediction; retrospective study; risk factor; sensitivity and specificity; survival rate; thorax radiography; Coronavirus infection; diagnostic imaging; lung; middle aged; mortality; pathology; predictive value; prognosis; receiver operating characteristic; virus pneumonia; x-ray computed tomography; Aged; China; Comorbidity; Coronavirus Infections; Female; Humans; Lung; Male; Middle Aged; Pneumonia, Viral; Predictive Value of Tests; Prognosis; Retrospective Studies; ROC Curve; Sensitivity and Specificity; Tomography, X-Ray Computed","(2019) Wuhan Municipal Health Commission's Briefing on the Pneumonia Epidemic Situation (In Chinese), 12, p. 31. , http://www.Wuhan.Gov.Cn/front/web/showdetail/2019123108989; (2020) Coronavirus, 2, p. 5. , https://www.Who.Int/zh/emergencies/diseases/novel-coronavirus-2019, Who; (2020) National Health Commission's Briefing on the Pneumonia Epidemic Situation, 2, p. 4. , http://www.Nhc.Gov.Cn/yjb/s7860/202002/17a03704a99646ffad6807bc806f37a4.Shtml; (2020) Coronavirus, 2, p. 5. , https://www.Who.Int/news-room/detail/30-01-2020-statement-on-thesecond-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-theoutbreak-of-novel-coronavirus-(2019-ncov, Who; Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study (2020) Lancet, , https://doi.org/10.1016/S0140-6736(20)30211-7, PMID: 32007143; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, , https://doi.org/10.1016/S0140-6736(20)30183-5, PMID: 31986264; Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) Jama, , https://doi.org/10.1001/jama.2020.1585, PMID: 32031570; (2020) Global Surveillance for Human Infection with Novel Coronavirus (2019-ncov) Interim Guidance V3, 1, p. 31. , https://www.Who.Int/publications-detail/global-surveillance-for-human-infection-with-novelcoronavirus-(2019-ncov, accessed feb 8, 2020; Feng, F., Jiang, Y., Yuan, M., Shen, J., Yin, H., Geng, D., Association of radiologic findings with mortality in patients with avian influenza H7N9 pneumonia (2014) PloS One, 9 (4), p. e93885. , https://doi.org/10.1371/journal.pone.0093885, PMID: 24705783; Yin, Y., Wunderink, R.G., MERS, SARS and other coronaviruses as causes of pneumonia (2018) Respirology (Carlton, Vic), 23 (2), pp. 130-137. , https://doi.org/10.1111/resp.13196, PMID: 29052924; Wang, W., Tang, J., Wei, F., Updated understanding of the outbreak of 2019 novel coronavirus (2019-ncov) in Wuhan, China (2020) Journal of Medical Virology, , https://doi.org/10.1002/jmv.25689, PMID: 31994742; Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) The New England Journal of Medicine, , https://doi.org/10.1056/NEJMoa2001316, PMID: 31995857; Shi, H., Han, X., Zheng, C., Evolution of ct manifestations in a patient recovered from 2019 novel coronavirus (2019-ncov) pneumonia in Wuhan, China (2020) Radiology, p. 200269. , https://doi.org/10.1148/radiol.2020200269, PMID: 32032497; Fang, Y., Zhang, H., Xu, Y., Xie, J., Pang, P., Ji, W., Ct manifestations of two cases of 2019 novel coronavirus (2019-ncov) pneumonia (2020) Radiology, p. 200280. , https://doi.org/10.1148/radiol.2020200280, PMID: 32031481; Song, F., Shi, N., Shan, F., Zhang, Z., Shen, J., Lu, H., Emerging coronavirus 2019-ncov pneumonia (2020) Radiology, p. 200274. , PMID: 32027573; Grinblat, L., Shulman, H., Glickman, A., Matukas, L., Paul, N., Severe acute respiratory syndrome: Radiographic review of 40 probable cases in toronto, Canada (2003) Radiology, 228 (3), pp. 802-809. , https://doi.org/10.1148/radiol.2283030671, PMID: 12853655; Marchiori, E., Zanetti, G., Fontes, C.A., Santos, M.L., Valiante, P.M., Mano, C.M., Influenza a (h1n1) virusassociated pneumonia: High-resolution computed tomography-pathologic correlation (2011) European Journal of Radiology, 80 (3), pp. e500-e504. , https://doi.org/10.1016/j.ejrad.2010.10.003, PMID: 21035974; Wang, Q., Zhang, Z., Shi, Y., Jiang, Y., Emerging h7n9 influenza a (novel reassortant avian-origin) pneumonia: Radiologic findings (2013) Radiology, 268 (3), pp. 882-889. , https://doi.org/10.1148/radiol.13130988, PMID: 23821754; Ooi, G.C., Khong, P.L., Muller, N.L., Yiu, W.C., Zhou, L.J., Ho, J.C., Severe acute respiratory syndrome: Temporal lung changes at thin-section ct in 30 patients (2004) Radiology, 230 (3), pp. 836-844. , https://doi.org/10.1148/radiol.2303030853, PMID: 14990845; Wong, K.T., Antonio, G.E., Hui, D.S., Lee, N., Yuen, E.H., Wu, A., Severe acute respiratory syndrome: Radiographic appearances and pattern of progression in 138 patients (2003) Radiology, 228 (2), pp. 401-406. , https://doi.org/10.1148/radiol.2282030593, PMID: 12759474; Al-Tawfiq, J.A., Zumla, A., Memish, Z.A., Coronaviruses: Severe acute respiratory syndrome coronavirus and middle east respiratory syndrome coronavirus in travelers (2014) Current Opinion in Infectious Diseases, 27 (5), pp. 411-417. , https://doi.org/10.1097/QCO.0000000000000089, PMID: 25033169; Ajlan, A.M., Ahyad, R.A., Jamjoom, L.G., Alharthy, A., Madani, T.A., Middle east respiratory syndrome coronavirus (mers-cov) infection: Chest ct findings (2014) Ajr American Journal of Roentgenology, 203 (4), pp. 782-787. , https://doi.org/10.2214/AJR.14.13021, PMID: 24918624","Hu, Y.; Department of Pulmonary and Critical Care Medicine, Huazhong University of Science and Technology, Central Hospital of WuhanChina; email: Huyi_pub@163.com",,Public Library of Science,19326203,,POLNC,32191764,English,PLoS ONE,Article,Final,Open Access,Scopus,2-s2.0-85082082571,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhao S., Ling K., Yan H., Zhong L., Peng X., Yao S., Huang J., Chen X.",57215769778;57215775007;57211152302;57215801344;57215776376;7402472375;23110843500;56440360700;,Anesthetic Management of Patients with COVID 19 Infections during Emergency Procedures,2020,Journal of Cardiothoracic and Vascular Anesthesia,34,5,,1125,1131,,,10.1053/j.jvca.2020.02.039,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081905548&doi=10.1053%2fj.jvca.2020.02.039&partnerID=40&md5=e3169f5fb91d2e1abdc2828cf93cf66e,"Department of Anesthesiology, Institute of Anesthesiology and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Anesthesiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Anesthesiology, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Anesthesiology, Wuhan Fourth Hospital in Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Anesthesiology and Perioperative Medicine, University of LouisvilleKY, United States","Zhao, S., Department of Anesthesiology, Institute of Anesthesiology and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, Department of Anesthesiology, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Ling, K., Department of Anesthesiology, Institute of Anesthesiology and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, Department of Anesthesiology, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Yan, H., Department of Anesthesiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Zhong, L., Department of Anesthesiology, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Peng, X., Department of Anesthesiology, Wuhan Fourth Hospital in Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Yao, S., Department of Anesthesiology, Institute of Anesthesiology and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Huang, J., Department of Anesthesiology and Perioperative Medicine, University of LouisvilleKY, United States; Chen, X., Department of Anesthesiology, Institute of Anesthesiology and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","Objectives: The aim of the present study was to prevent cross-infection in the operating room during emergency procedures for patients with confirmed or suspected 2019 novel coronavirus (2019-nCoV) by following anesthesia management protocols, and to document clinical- and anesthesia-related characteristics of these patients. Design: This was a retrospective, multicenter clinical study. Setting: This study used a multicenter dataset from 4 hospitals in Wuhan, China. Participants: Patients and health care providers with confirmed or suspected 2019-nCoV from January 23 to 31, 2020, at the Wuhan Union Hospital, the Wuhan Children's Hospital, The Central Hospital of Wuhan, and the Wuhan Fourth Hospital in Wuhan, China. Interventions: Anesthetic management and infection control guidelines for emergency procedures for patients with suspected 2019-nCoV were drafted and applied in 4 hospitals in Wuhan. Measurements and Main Results: Cross-infection in the operating rooms of the 4 hospitals was effectively reduced by implementing the new measures and procedures. The majority of patients with laboratory-confirmed 2019-nCoV infection or suspected infection were female (23 [62%] of 37), and the mean age was 41.0 years old (standard deviation 19.6; range 4-78). 10 (27%) patients had chronic medical illnesses, including 4 (11%) with diabetes, 8 (22%) with hypertension, and 8 (22%) with digestive system disease. Twenty-five (68%) patients presented with lymphopenia, and 23 (62%) patients exhibited multiple mottling and ground-glass opacity on computed tomography scanning. Conclusions: The present study indicates that COVID 19–specific guidelines for emergency procedures for patients with confirmed or suspected 2019-nCoV may effectively prevent cross-infection in the operating room. Most patients with confirmed or suspected COVID 19 presented with fever and dry cough and demonstrated bilateral multiple mottling and ground-glass opacity on chest computed tomography scans. © 2020 Elsevier Inc.",2019 nCoV; 2019 novel coronavirus; COVID 19; cross-infection; infection control; occupational health; viral pneumonia,,"December, I., A novel coronavirus outbreak of global health concern (2020) Lancet, 395, pp. 470-473; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506; Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382, pp. 727-733; World Health Organization, (2020), https://www.who.int/emergencies/diseases/novel-coronavirus-2019, Coronavirus disease (COVID-19) outbreak. Available at: Accessed January 30; Centers for Disease Control and Prevention, (2020), https://www.cdc.gov/coronavirus/2019-ncov/index.html, Coronavirus disease 2019 (COVID-19). Available at: Accessed January 30; Fuk-Woo Chan, J., Yuan, S., Kok, K.-H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: A study of a family cluster (2020) Lancet, 6736, pp. 1-10; Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med, , [E-pub ahead of print]; De Wit, E., Van Doremalen, N., Falzarano, D., SARS and MERS: Recent insights into emerging coronaviruses (2016) Nat Rev Microbiol, 14, pp. 523-534; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study (2020) Lancet, 395, pp. 507-513; Lofy, K.H., Wiesman, J., Bruce, H., First case of 2019 novel coronavirus in the United States (2020) N Engl J Med, , [E-pub ahead of print]; Ksiazek, T.G., Erdman, D., Goldsmith, C.S., A novel coronavirus associated with severe acute respiratory syndrome (2003) N Engl J Med, 348, pp. 1953-1966; Drosten, C., Gunther, S., Preiser, W., Identification of a novel coronavirus in patients with severe acute respiratory syndrome (2003) N Engl J Med, 348, pp. 1967-1976; de Groot, R.J., Baker, S.C., Baric, R.S., Middle East respiratory syndrome coronavirus (MERS-CoV): Announcement of the Coronavirus Study Group (2013) J Virol, 87, pp. 7790-7792; Zaki, A.M., van Boheemen, S., Bestebroer, T.M., Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia (2012) N Engl J Med, 367, pp. 1814-1820; Radonovich, L.J., Simberkoff, M.S., Bessesen, M.T., N95 respirators vs medical masks for preventing influenza among health care personnel: A randomized clinical trial (2019) JAMA, 322, pp. 824-833","Huang, J.; Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyChina",,W.B. Saunders,10530770,,JCVAE,32178954,English,J. Cardiothorac. Vasc. Anesth.,Article,Final,Open Access,Scopus,2-s2.0-85081905548,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Shen C., Yu N., Cai S., Zhou J., Sheng J., Liu K., Zhou H., Guo Y., Niu G.",57194550010;56185906500;57215699769;57215685348;57215697721;57215695612;57215683354;55617016900;57215694870;,Quantitative computed tomography analysis for stratifying the severity of Coronavirus Disease 2019,2020,Journal of Pharmaceutical Analysis,,,,,,,,10.1016/j.jpha.2020.03.004,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081664551&doi=10.1016%2fj.jpha.2020.03.004&partnerID=40&md5=e6eeee95068abc01fbe6541f8dd54c74,"Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China; Department of Radiology, The Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Xianyang, Shaanxi 712000, China; Department of Radiology, Xi'an Chest Hospital, Xi'an, Shaanxi 710100, China; Department of Radiology, Hanzhong Central Hospital, Hanzhong, Shaanxi 723000, China; Department of CT&MR Imaging, Weinan Central Hospital, Weinan, Shaanxi 714000, China; Department of Radiology, Ankang Central Hospital, Ankang, Shaanxi 725000, China","Shen, C., Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China; Yu, N., Department of Radiology, The Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine, Xianyang, Shaanxi 712000, China; Cai, S., Department of Radiology, Xi'an Chest Hospital, Xi'an, Shaanxi 710100, China; Zhou, J., Department of Radiology, Xi'an Chest Hospital, Xi'an, Shaanxi 710100, China; Sheng, J., Department of Radiology, Hanzhong Central Hospital, Hanzhong, Shaanxi 723000, China; Liu, K., Department of CT&MR Imaging, Weinan Central Hospital, Weinan, Shaanxi 714000, China; Zhou, H., Department of Radiology, Ankang Central Hospital, Ankang, Shaanxi 725000, China; Guo, Y., Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China; Niu, G., Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China","Purpose: To examine the feasibility of using a computer tool for stratifying the severity of Coronavirus Disease 2019 (COVID-19) based on computed tomography (CT) images. Materials and methods: We retrospectively examined 44 confirmed COVID-19 cases. All cases were evaluated separately by radiologists (visually) and through an in-house computer software. The degree of lesions was visually scored by the radiologist, as follows, for each of the 5 lung lobes: 0, no lesion present; 1, <1/3 involvement; 2, >1/3 and < 2/3 involvement; and 3, >2/3 involvement. Lesion density was assessed based on the proportion of ground-glass opacity (GGO), consolidation and fibrosis of the lesions. The parameters obtained using the computer tool included lung volume (mL), lesion volume (mL), lesion percentage (%), and mean lesion density (HU) of the whole lung, right lung, left lung, and each lobe. The scores obtained by the radiologists and quantitative results generated by the computer software were tested for correlation. A Chi-square test was used to test the consistency of radiologist- and computer-derived lesion percentage in the right/left lung, upper/lower lobe, and each of the 5 lobes. Result: The results showed a strong to moderate correlation between lesion percentage scores obtained by radiologists and the computer software (r ranged from 0.7679 to 0.8373, P < 0.05), and a moderate correlation between the proportion of GGO and mean lesion density (r = −0.5894, P < 0.05), and proportion of consolidation and mean lesion density (r = 0.6282, P < 0.05). Computer-aided quantification showed a statistical significant higher lesion percentage for lower lobes than that assessed by the radiologists (χ2 = 8.160, P = 0.004). Conclusions: Our experiments demonstrated that the computer tool could reliably and accurately assess the severity and distribution of pneumonia on CT scans. © 2020 Xi'an Jiaotong University",Coronavirus disease 2019 (COVID-19); Quantitative computed tomography (QCT); Severity stratification,,"Zhu, N., Zhang, D.Y., Wang, W.L., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N. Engl. J. Med., 382, pp. 727-733; Zhou, P., Yang, X.L., Wang, X.G., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature, , Epub ahead of print; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506; Zu, Z.Y., Jiang, M.D., Xu, P.P., Coronavirus Disease 2019 (COVID-19): A Perspective from China (2020) Radiology, , Epub ahead of print); Jin, Y.H., Cai, L., Cheng, Z.S., A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version) (2020) Mil. Med. Res., , Epub ahead of print; Xie, X., Zhong, Z., Zhao, W., Chest CT for typical 2019-nCoV pneumonia: relationship to negative RT-PCR testing (2020) Radiology, , Epub ahead of print; Wang, D., Hu, B., Hu, C., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) J. Am. Med. Assoc., , Epub ahead of print; Pan, Y., Guan, H., Zhou, S., Initial CT findings and temporal changes in patients with the novel coronavirus pneumonia (2019-nCoV): a study of 63 patients in Wuhan, China (2020) Eur. Radiol., , Epub ahead of print; Pan, F., Ye, T., Sun, P., Time course of lung changes on chest CT during recovery from 2019 novel coronavirus (COVID-19) pneumonia (2020) Radiology, , Epub ahead of print; National Health Commission of the People's Republic of China, Diagnosis and treatment protocols of Coronavirus Disease 2019 (trial version 6) (2020), http://www.nhc.gov.cn/xcs/zhengcwj/202002/8334a8326dd94d329df351d7da8aefc2.shtml; Hansell, D.M., Bankier, A.A., MacMahon, H., Fleischner Society, Glossary of terms for thoracic imaging (2008) Radiology, 246, pp. 697-722; Koo, H.J., Lim, S., Choe, J., Radiographic and CT features of viral pneumonia (2018) Radiographics, 38, pp. 719-739; Chan, E.G., Landreneau, J.R., Schuchert, M.J., Preoperative (3-dimensional) computed tomography lung reconstruction before anatomic segmentectomy or lobectomy for stage I non-small cell lung cancer (2015) J. Thorac. Cardiovasc. Surg., 150, pp. 523-528; Pu, J., Roos, J., Yi, C.A., Adaptive border marching algorithm: automatic lung segmentation on chest CT images (2008) Comput. Med. Imag. Graph., 32, pp. 452-462; Pu, J., Zheng, B., Leader, J.K., Pulmonary lobe segmentation in CT examinations using implicit surface fitting (2009) IEEE Trans. Med. Imag., 28, pp. 1986-1996; Gu, S., Fuhrman, C., Meng, X., Computerized identification of airway wall in CT examinations using a 3D active surface evolution approach (2013) Med. Image Anal., 17, pp. 283-296; Wang, X., Leader, J.K., Wang, R., Vasculature surrounding a nodule: a novel lung cancer biomarker (2017) Lung Canc., 114, pp. 38-43; Lassen, B.C., Jacobs, C., Kuhnigk, J.M., Robust semi-automatic segmentation of pulmonary subsolid nodules in chest computed tomography scans (2015) Phys. Med. Biol., 60, pp. 1307-1323; Tian, S., Hu, W., Niu, L., Pulmonary pathology of early phase 2019 novel coronavirus (COVID-19) pneumonia in two patients with lung cancer (2020) J. Thorac. Oncol., , Epub ahead of print; Ishiguro, T., Kobayashi, Y., Uozumi, R., Viral pneumonia requiring differentiation from acute and progressive diffuse interstitial lung diseases (2019) Intern. Med., 58, pp. 3509-3519; Wu, J., Wu, X., Zeng, W., Chest CT findings in patients with corona virus disease 2019 and its relationship with clinical features (2020) Invest. Radiol., , Epub ahead of print","Niu, G.; Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Road, China; email: niugang369@xjtu.edu.cn",,Xi'an Jiaotong University,20951779,,,,English,J. Pharmaceut.Analy.,Article,Article in Press,Open Access,Scopus,2-s2.0-85081664551,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Xu Y.-H., Dong J.-H., An W.-M., Lv X.-Y., Yin X.-P., Zhang J.-Z., Dong L., Ma X., Zhang H.-J., Gao B.-L.",57215607285;57215038663;57203178487;57215604591;56783444700;57196388942;57215600530;57215605304;57215613385;12782005800;,Clinical and computed tomographic imaging features of novel coronavirus pneumonia caused by SARS-CoV-2,2020,Journal of Infection,80,4,,394,400,,,10.1016/j.jinf.2020.02.017,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081375950&doi=10.1016%2fj.jinf.2020.02.017&partnerID=40&md5=0e38e77f9a88fdcca964276955e81b95,"Department of Radiology, The Fifth Medical Center of Chinese PLA General Hospital, 100 West Fourth Ring Road, Fengtai District, Beijing, 100039, China; CT/MRI Room, Affiliated Hospital of Hebei University, 212 Eastern Yuhua Road, Baoding, Hebei Province 071000, China; Department of Radiology, Baoding City People's Hospital, Baoding, Hebei Province 071000, China; Clinical College, Hebei University, Boding, Hebei Province, China","Xu, Y.-H., Department of Radiology, The Fifth Medical Center of Chinese PLA General Hospital, 100 West Fourth Ring Road, Fengtai District, Beijing, 100039, China; Dong, J.-H., Department of Radiology, The Fifth Medical Center of Chinese PLA General Hospital, 100 West Fourth Ring Road, Fengtai District, Beijing, 100039, China; An, W.-M., Department of Radiology, The Fifth Medical Center of Chinese PLA General Hospital, 100 West Fourth Ring Road, Fengtai District, Beijing, 100039, China; Lv, X.-Y., Department of Radiology, The Fifth Medical Center of Chinese PLA General Hospital, 100 West Fourth Ring Road, Fengtai District, Beijing, 100039, China; Yin, X.-P., CT/MRI Room, Affiliated Hospital of Hebei University, 212 Eastern Yuhua Road, Baoding, Hebei Province 071000, China; Zhang, J.-Z., Department of Radiology, The Fifth Medical Center of Chinese PLA General Hospital, 100 West Fourth Ring Road, Fengtai District, Beijing, 100039, China; Dong, L., Department of Radiology, Baoding City People's Hospital, Baoding, Hebei Province 071000, China; Ma, X., CT/MRI Room, Affiliated Hospital of Hebei University, 212 Eastern Yuhua Road, Baoding, Hebei Province 071000, China; Zhang, H.-J., Clinical College, Hebei University, Boding, Hebei Province, China; Gao, B.-L., Department of Radiology, The Fifth Medical Center of Chinese PLA General Hospital, 100 West Fourth Ring Road, Fengtai District, Beijing, 100039, China","Purpose: To investigate the clinical and imaging characteristics of computed tomography (CT) in novel coronavirus pneumonia (NCP) caused by SARS-CoV-2. Materials and methods: A retrospective analysis was performed on the imaging findings of patients confirmed with COVID-19 pneumonia who had chest CT scanning and treatment after disease onset. The clinical and imaging data were analyzed. Results: Fifty patients were enrolled, including mild type in nine, common in 28, severe in 10 and critically severe in the rest three. Mild patients (29 years) were significantly (P<0.03) younger than either common (44.5 years) or severe (54.7) and critically severe (65.7 years) patients, and common patients were also significantly (P<0.03) younger than severe and critically severe patients. Mild patients had low to moderate fever (<39.1 °C), 49 (98%) patients had normal or slightly reduced leukocyte count, 14 (28%) had decreased counts of lymphocytes, and 26 (52%) patients had increased C-reactive protein. Nine mild patients were negative in CT imaging. For all the other types of NCP, the lesion was in the right upper lobe in 30 cases, right middle lobe in 22, right lower lobe in 39, left upper lobe in 33 and left lower lobe in 36. The lesion was primarily located in the peripheral area under the pleura with possible extension towards the pulmonary hilum. Symmetrical lesions were seen in 26 cases and asymmetrical in 15. The density of lesion was mostly uneven with ground glass opacity as the primary presentation accompanied by partial consolidation and fibrosis. Conclusion: CT imaging presentations of NCP are mostly patchy ground glass opacities in the peripheral areas under the pleura with partial consolidation which will be absorbed with formation of fibrotic stripes if improved. CT scanning provides important bases for early diagnosis and treatment of NCP. © 2020 The British Infection Association",Computed tomography; Covid-19; Imaging finding; Novel coronavirus pneumonia; SARS-CoV-2,,"Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in wuhan, china (2020) Lancet, 395 (10223), pp. 497-506; Kui, L., Fang, Y.Y., Deng, Y., Liu, W., Wang, M.F., Ma, J.P., Clinical characteristics of novel coronavirus cases in tertiary hospitals in hubei province (2020) Chin Med J (Engl), , [Epub ahead of print]; Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in wuhan, china (2020) JAMA, , [Epub ahead of print]; Jiang, X., Rayner, S., Luo, M.H., Does sars-cov-2 has a longer incubation period than sars and mers? (2020) J Med Virol, , [Epub ahead of print]; Lorusso, A., Calistri, P., Petrini, A., Savini, G., Decaro, N., Novel coronavirus (sars-cov-2) epidemic: a veterinary perspective (2020) Vet Ital, , [Epub ahead of print]; Lin, L., Li, T.S., [interpretation of ""guidelines for the diagnosis and treatment of novel coronavirus (2019-ncov) infection by the national health commission (trial version 5)""] (2020) Zhonghua Yi Xue Za Zhi, 100 (0), p. E001. , [Epub ahead of print]; Pan, Y., Guan, H., Imaging changes in patients with 2019-ncov (2020) Eur Radiol, , [Epub ahead of print]; Guan, W., Xian, J., The progress of 2019 novel coronavirus (2019-ncov) event in china (2020) J Med Virol, , [Epub ahead of print]; Shen, K., Yang, Y., Wang, T., Zhao, D., Jiang, Y., Jin, R., Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts' consensus statement (2020) World J Pediatr, , [Epub ahead of print]; Wang, Z., Chen, X., Lu, Y., Chen, F., Zhang, W., Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined chinese and western medicine treatment (2020) Biosci Trends, , [Epub ahead of print]; Wu, Y.C., Chen, C.S., Chan, Y.J., Overview of the 2019 novel coronavirus (2019-ncov): the pathogen of severe specific contagious pneumonia (sscp) (2020) J Chin Med Assoc, , [Epub ahead of print]; Wong, K.T., Antonio, G.E., Hui, D.S., Lee, N., Yuen, E.H., Wu, A., Thin-section ct of severe acute respiratory syndrome: evaluation of 73 patients exposed to or with the disease (2003) Radiology, 228, pp. 395-400; Chung, M., Bernheim, A., Mei, X., Zhang, N., Huang, M., Zeng, X., Ct imaging features of 2019 novel coronavirus (2019-ncov) (2020) Radiology, , [Epub ahead of print]; Lei, J., Li, J., Li, X., Qi, X., Ct imaging of the 2019 novel coronavirus (2019-ncov) pneumonia (2020) Radiology, , [Epub ahead of print]; Shi, H., Han, X., Zheng, C., Evolution of ct manifestations in a patient recovered from 2019 novel coronavirus (2019-ncov) pneumonia in Wuhan, China (2020) Radiology, , [Epub ahead of print]; Xie, X., Zhong, Z., Zhao, W., Zheng, C., Wang, F., Liu, J., Chest ct for typical 2019-ncov pneumonia: relationship to negative rt-pcr testing (2020) Radiology, , [Epub ahead of print]","Lv, X.-Y.; Department of Radiology, The Fifth Medical Center of Chinese PLA General Hospital, 100 West Fourth Ring Road, Fengtai District, China; email: 15001008285@139.com",,W.B. Saunders Ltd,1634453,,JINFD,32109443,English,J. Infect.,Article,Final,Open Access,Scopus,2-s2.0-85081375950,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Kruse R.L.,57214331148;,"Therapeutic strategies in an outbreak scenario to treat the novel coronavirus originating in Wuhan, China",2020,F1000Research,9,,,72,,,2,10.12688/f1000research.22211.2,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080839534&doi=10.12688%2ff1000research.22211.2&partnerID=40&md5=8cdac4341a520b514b00b25795694ae0,"Department of Pathology, Johns Hopkins Hospital, Baltimore, MD 21287, United States","Kruse, R.L., Department of Pathology, Johns Hopkins Hospital, Baltimore, MD 21287, United States","A novel coronavirus (2019-nCoV) originating in Wuhan, China presents a potential respiratory viral pandemic to the world population. Current efforts are focused on containment and quarantine of infected individuals. Ultimately, the outbreak could be controlled with a protective vaccine to prevent 2019-nCoV infection. While vaccine research should be pursued intensely, there exists today no therapy to treat 2019-nCoV upon infection, despite an urgent need to find options to help these patients and preclude potential death. Herein, I review the potential options to treat 2019-nCoV in patients, with an emphasis on the necessity for speed and timeliness in developing new and effective therapies in this outbreak. I consider the options of drug repurposing, developing neutralizing monoclonal antibody therapy, and an oligonucleotide strategy targeting the viral RNA genome, emphasizing the promise and pitfalls of these approaches. Finally, I advocate for the fastest strategy to develop a treatment now, which could be resistant to any mutations the virus may have in the future. The proposal is a biologic that blocks 2019-nCoV entry using a soluble version of the viral receptor, angiotensin-converting enzyme 2 (ACE2), fused to an immunoglobulin Fc domain, providing a neutralizing antibody with maximal breath to avoid any viral escape, while also helping to recruit the immune system to build lasting immunity. The sequence of the ACE2-Fc protein is provided to investigators, allowing its possible use in recombinant protein expression systems to start producing drug today to treat patients under compassionate use, while formal clinical trials are later undertaken. Such a treatment could help infected patients before a protective vaccine is developed and widely available in the coming months to year(s). Copyright: © 2020 Kruse RL.",2019-nCoV; ACE2; coronavirus; neutralizing antibody; outbreak; Wuhan,"angiotensin converting enzyme 2; COVID-19; dipeptidyl carboxypeptidase; monoclonal antibody; neutralizing antibody; oligonucleotide; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; China; compassionate use; Coronavirus infection; drug effect; drug repositioning; epidemic; epidemiology; human; virus pneumonia; Antibodies, Monoclonal; Antibodies, Neutralizing; Betacoronavirus; China; Compassionate Use Trials; Coronavirus Infections; Disease Outbreaks; Drug Repositioning; Humans; Oligonucleotides; Peptidyl-Dipeptidase A; Pneumonia, Viral",,,,NLM (Medline),20461402,,,32117569,English,F1000Res,Review,Final,Open Access,Scopus,2-s2.0-85080839534,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Lai T.H.T., Tang E.W.H., Chau S.K.Y., Fung K.S.C., Li K.K.W.",57195410931;7006462058;55151628900;8948874600;55767216100;,Stepping up infection control measures in ophthalmology during the novel coronavirus outbreak: an experience from Hong Kong,2020,Graefe's Archive for Clinical and Experimental Ophthalmology,,,,,,,3,10.1007/s00417-020-04641-8,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081587501&doi=10.1007%2fs00417-020-04641-8&partnerID=40&md5=38a22d718ea1264dd3eb3c190166f3a3,"Department of Ophthalmology, United Christian Hospital, 130 Hip Wo Street, Kwun Tong, Kowloon, Hong Kong; Department of Ophthalmology, Tseung Kwan O Hospital, 2 Po Ning Path, Tseung Kwan O, Hong Kong; Department of Pathology, Tseung Kwan O Hospital, 2 Po Ning Path, Tseung Kwan O, Hong Kong; Department of Pathology, United Christian Hospital, 130 Hip Wo Street, Kwun Tong, Kowloon, Hong Kong","Lai, T.H.T., Department of Ophthalmology, United Christian Hospital, 130 Hip Wo Street, Kwun Tong, Kowloon, Hong Kong, Department of Ophthalmology, Tseung Kwan O Hospital, 2 Po Ning Path, Tseung Kwan O, Hong Kong; Tang, E.W.H., Department of Ophthalmology, United Christian Hospital, 130 Hip Wo Street, Kwun Tong, Kowloon, Hong Kong, Department of Ophthalmology, Tseung Kwan O Hospital, 2 Po Ning Path, Tseung Kwan O, Hong Kong; Chau, S.K.Y., Department of Pathology, Tseung Kwan O Hospital, 2 Po Ning Path, Tseung Kwan O, Hong Kong; Fung, K.S.C., Department of Pathology, United Christian Hospital, 130 Hip Wo Street, Kwun Tong, Kowloon, Hong Kong; Li, K.K.W., Department of Ophthalmology, United Christian Hospital, 130 Hip Wo Street, Kwun Tong, Kowloon, Hong Kong, Department of Ophthalmology, Tseung Kwan O Hospital, 2 Po Ning Path, Tseung Kwan O, Hong Kong","Purpose: Coronavirus disease (COVID-19) has rapidly emerged as a global health threat. The purpose of this article is to share our local experience of stepping up infection control measures in ophthalmology to minimise COVID-19 infection of both healthcare workers and patients. Methods: Infection control measures implemented in our ophthalmology clinic are discussed. The measures are based on detailed risk assessment by both local ophthalmologists and infection control experts. Results: A three-level hierarchy of control measures was adopted. First, for administrative control, in order to lower patient attendance, text messages with an enquiry phone number were sent to patients to reschedule appointments or arrange drug refill. In order to minimise cross-infection of COVID-19, a triage system was set up to identify patients with fever, respiratory symptoms, acute conjunctivitis or recent travel to outbreak areas and to encourage these individuals to postpone their appointments for at least 14 days. Micro-aerosol generating procedures, such as non-contact tonometry and operations under general anaesthesia were avoided. Nasal endoscopy was avoided as it may provoke sneezing and cause generation of droplets. All elective clinical services were suspended. Infection control training was provided to all clinical staff. Second, for environmental control, to reduce droplet transmission of COVID-19, installation of protective shields on slit lamps, frequent disinfection of equipment, and provision of eye protection to staff were implemented. All staff were advised to measure their own body temperatures before work and promptly report any symptoms of upper respiratory tract infection, vomiting or diarrhoea. Third, universal masking, hand hygiene, and appropriate use of personal protective equipment (PPE) were promoted. Conclusion: We hope our initial experience in stepping up infection control measures for COVID-19 infection in ophthalmology can help ophthalmologists globally to prepare for the potential community outbreak or pandemic. In order to minimise transmission of COVID-19, ophthalmologists should work closely with local infection control teams to implement infection control measures that are appropriate for their own clinical settings. © 2020, Springer-Verlag GmbH Germany, part of Springer Nature.",Coronavirus; COVID-19; Hong Kong; Infection control; Ophthalmology; SARS-CoV-2,,"(2020), https://www.who.int/dg/speeches/detail/who-director-general-s-remarks-at-the-media-briefing-on-2019-ncov-on-11-february-2020, World Health Organization; (2020), https://www.ecdc.europa.eu/en/novel-coronavirus-china, World Health Organization, Accessed 18 Feb 2020; (2020) Centers for Disease Control and Prevention, , https://www.cdc.gov/coronavirus/2019-ncov/about/symptoms.html, Accessed 16 Feb 2020; Guan, W.-J., Ni, Z.-Y., Hu, Y., Liang, W.-H., Ou, C.-Q., He, J.-X., Liu, L., Zhong, N.-S., (2020) Clinical Characteristics of 2019 Novel Coronavirus Infection in China, , 2020.2002.2006.20020974; The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) (2020) China CDC Weekly; (2020), https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200227-sitrep-38-covid-19.pdf?sfvrsn=9f98940c_2, Situation Report – 38, World Health Organization, Accessed 28 Feb 2020; (2020) Centre for Health Protection, Department of Health, , https://chp-dashboard.geodata.gov.hk/covid-19/en.html, Hong Kong Special Administrative Region, Accessed 27 Feb 2020; (2020), https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200214-sitrep-25-covid-19.pdf?sfvrsn=61dda7d_2, World Health Organization, Accessed 15 Feb 2020; (2020), https://www.who.int/dg/speeches/detail/who-director-general-s-remarks-at-the-media-briefing-on-covid-2019-outbreak-on-14-february-2020, World Health Organization, Accessed 15 Feb 2020; (2020) American Academy of Ophthalmology, , https://www.aao.org/headline/coronavirus-kills-chinese-whistleblower-ophthalmol, Accessed 15 Feb 2020; Chang, D., Xu, H., Rebaza, A., Sharma, L., Dela Cruz, C.S., Protecting health-care workers from subclinical coronavirus infection (2020) The Lancet Respiratory Medicine, 8 (3); Zhou, Y., Zeng, Y., Tong, Y., Chen, C., (2020) Ophthalmologic Evidence against the Interpersonal Transmission of 2019 Novel Coronavirus through Conjunctiva, , https://doi.org/10.1101/2020.02.11.20021956, 2020.2002.2011.20021956; Lu, C.-W., Liu, X.-F., Jia, Z.-F., 2019-nCoV transmission through the ocular surface must not be ignored (2020) The Lancet, 395 (10224); (2020) American Academy of Ophthalmology, , https://www.aao.org/headline/alert-important-coronavirus-context, Accessed 18 Feb 2020; Loon, S.C., Teoh, S.C., Oon, L.L., Se-Thoe, S.Y., Ling, A.E., Leo, Y.S., Leong, H.N., The severe acute respiratory syndrome coronavirus in tears (2004) Br J Ophthalmol, 88 (7), pp. 861-863; Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Wang, B., Peng, Z., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) Jama, , (,),.,., https://doi.org/10.1001/jama.2020.1585; What Happens at an Eye Exam? 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(2003) J R Soc Med, 96 (8), pp. 374-378","Li, K.K.W.; Department of Ophthalmology, Tseung Kwan O Hospital, 2 Po Ning Path, Hong Kong; email: kennethli@rcsed.ac.uk",,Springer,0721832X,,GACOD,32124000,English,Graefe's Arch. Clin. Exp. Ophthalmol.,Article,Article in Press,Open Access,Scopus,2-s2.0-85081587501,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Al-Ahmadi K., Alahmadi M., Al-Zahrani A.",24066132400;55699855100;23487960500;,Spatial association between primary Middle East respiratory syndrome coronavirus infection and exposure to dromedary camels in Saudi Arabia,2020,Zoonoses and Public Health,,,,,,,,10.1111/zph.12697,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080145108&doi=10.1111%2fzph.12697&partnerID=40&md5=25a1cce46878987de52aeb77f22bce4a,"King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia; King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia","Al-Ahmadi, K., King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia; Alahmadi, M., King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia; Al-Zahrani, A., King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia","Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging zoonotic disease. Exposure to dromedary camels (Camelus dromedaries) has been consistently considered the main source of primary human infection. Although Saudi Arabia reports the highest rate of human MERS-CoV infection and has one of the largest populations of dromedary camels worldwide, their spatial association has not yet been investigated. Thus, this study aimed to examine the correlation between the spatial distribution of primary MERS-CoV cases with or without a history of camel exposure reported between 2012 and 2019 and dromedary camels at the provincial level in Saudi Arabia. In most provinces, a high proportion of older men develop infections after exposure to camels. Primary human infections during spring and winter were highest in provinces characterized by seasonal breeding and calving, increased camel mobilization and camel–human interactions. A strong and significant association was found between the total number of dromedary camels and the numbers of primary camel-exposed and non-exposed MERS-CoV cases. Furthermore, spatial correlations between MERS-CoV cases and camel sex, age and dairy status were significant. Via a cluster analysis, we identified Riyadh, Makkah and Eastern provinces as having the most primary MERS-CoV cases and the highest number of camels. Transmission of MERS-CoV from camels to humans occurs in most primary cases, but there is still a high proportion of primary infections with an ambiguous link to camels. The results from this study include significant correlations between primary MERS-CoV cases and camel populations in all provinces, regardless of camel exposure history. This supports the hypothesis of the role of an asymptomatic human carrier or, less likely, an unknown animal host that has direct contact with both infected camels and humans. In this study, we performed a preliminary risk assessment of prioritization measures to control the transmission of infection from camels to humans. © 2020 Blackwell Verlag GmbH",dromedary camels; epidemiology; geographic information system; MERS-CoV; Saudi Arabia; zoonosis,,"Abbas, B., Al Qarawi, A.A., Al Hawas, A., Enquête sur des élevges de dromadaires dans la région de Qassim en Arabie saoudite: stratégies de conduite, productivité et mortalité (2000) Revue D’elevage Et De Médecine Vétérinaire Des Pays Tropicaux, 53, pp. 293-297. , https://doi.org/10.19182/remvt.9727; Abdallah, H.R., Faye, H., Typology of camel farming system in Saudi Arabia (2013) Emirates Journal of Food and Agriculture, 25 (4), pp. 250-260. , https://doi.org/10.9755/ejfa.v25i4.15491; Alagaili, A.N., Briese, T., Mishra, N., Kapoor, V., Sameroff, S.C., Burbelo, P.D., Lipkin, W.I., Middle East Respiratory Syndrome Coronavirus Infection in Dromedary Camels in Saudi Arabia (2014) MBio, 5 (2), pp. e00884-e914. , https://doi.org/10.1128/mbio.01002-14; Ali, M., El-Shesheny, R., Kandeil, A., Shehata, M., Elsokary, B., Gomaa, M., Makonnen, Y.J., Cross-sectional surveillance of Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels and other mammals in Egypt, August 2015 to January 2016 (2017) Eurosurveillance, 22, p. 30487. , https://doi.org/10.2807/1560-7917.es.2017.22.11.30487; Alraddadi, B.M., Watson, J.T., Almarashi, A., Abedi, G.R., Turkistani, A., Sadran, M., Madani, T.A., Risk factors for primary Middle East respiratory syndrome coronavirus illness in humans, Saudi Arabia, 2014 (2016) Emerging Infectious Diseases, 22 (1), pp. 49-55. , https://doi.org/10.3201/eid2201.151340; Alshukairi, A.N., Zheng, J., Zhao, J., Nehdi, A., Baharoon, S.A., Layqah, L., Alagaili, A.N., High Prevalence of MERS-CoV Infection in Camel Workers in Saudi Arabia (2018) MBio, 9 (5), pp. e01985-e2018. , https://doi.org/10.1128/mBio.01985-18; Al-Tawfiq, J.A., Memish, Z.A., Middle East respiratory syndrome coronavirus: Epidemiology and disease control measures (2014) Infection and Drug Resistance, 7, pp. 281-287. , https://doi.org/10.2147/IDR.S51283; Auty, R.M., (2001) Resource abundance and economic development, , Oxford, UK, Oxford University Press; Azhar, E.I., El-Kafrawy, S.A., Farraj, S.A., Hassan, A.M., Al-Saeed, M.S., Hashem, A.M., Madani, T.A., Evidence for camel-to-human transmission of MERS coronavirus (2014) New England Journal of Medicine, 370, pp. 2499-2505. , https://doi.org/10.1056/nejmoa1401505; Corman, V.M., Müller, M.A., Costabel, U., Timm, J., Binger, T., Meyer, B., Drosten, C., Assays for laboratory confirmation of novel human coronavirus (hCoV-EMC) infections (2012) Eurosurveillance, 17, p. 20334. , https://doi.org/10.2807/ese.17.49.20334-en; Dudas, G., Carvalho, L.M., Rambaut, A., Bedford, T., Correction: MERS-CoV spillover at the camel-human interface (2018) eLife, 7. , https://doi.org/10.7554/elife.37324; Duque, J.C., Ramos, R., Suriñach, J., Supervised regionalization methods: A survey (2007) International Regional Science Review, 30 (3), pp. 195-220. , https://doi.org/10.1177/0160017607301605; Elfadil, A.A.M., Ahmed, A.G., Abdalla, M.O., Gumaa, E., Osman, O.H., Younis, A.E., Qasim, I.A., Epidemiological study of Middle East respiratory syndrome coronavirus infection in dromedary camels in the Kingdom of Saudi Arabia, April–May 2015 (2018) Revue Scientifique Et Technique (International Office of Epizootics), 37, pp. 985-997. , https://doi.org/10.20506/rst.37.3.2901; Faye, B., Camel meat in the world (2013) Camel meat and meat products, pp. 7-16. , I. 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Version 5.1, , https://www.moh.gov.sa/CCC/healthp/regulations/Documents/MERS-CoV%20Guidelines%20for%20Healthcare%20Professionals%20-%20May%202018%20-%20v5.1%20%281%29.pdf, Retrieved from; (2019) Command and control center, , https://www.moh.gov.sa/en/CCC/Pages/default.aspx, Retrieved from; Müller, M.A., Meyer, B., Corman, V.M., Al-Masri, M., Turkestani, A., Ritz, D., Memish, Z.A., Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: A nationwide, cross-sectional, serological study (2015) The Lancet Infectious Diseases, 15, pp. 559-564. , https://doi.org/10.1016/s1473-3099(15)70090-3; Omrani, A.S., Al-Tawfiq, J.A., Memish, Z.A., Middle East respiratory syndrome coronavirus (MERS-CoV): Animal to human interaction (2015) Pathogens and Global Health, 109, pp. 354-362. , https://doi.org/10.1080/20477724.2015.1122852; Padalino, B., Monaco, D., Lacalandra, G., Male camel behavior and breeding management strategies: How to handle a camel bull during the breeding season? (2015) Emirates Journal of Food and Agriculture, 27, pp. 338-349. , https://doi.org/10.9755/ejfa.v27i4.19909; Pimpler, E., (2017) Spatial analytics with ArcGIS, , Birmingham, UK, Packt Publishing Ltd; Reeves, T., Samy, A.M., Peterson, A.T., MERS-CoV geography and ecology in the Middle East: Analyses of reported camel exposures and a preliminary risk map (2015) BMC Research Notes, 8, p. 801. , https://doi.org/10.1186/s13104-015-1789-1; Reusken, C., Ababneh, M., Raj, V., Meyer, B., Eljarah, A., Abutarbush, S., Koopmans, M., Middle East respiratory syndrome coronavirus (MERS-CoV) serology in major livestock species in an affected region in Jordan, June to September 2013 (2013) Eurosurveillance, 18, p. 20662. , https://doi.org/10.2807/1560-7917.es2013.18.50.20662; Reusken, C.B., Farag, E.A., Jonges, M., Godeke, G.J., El-Sayed, A.M., Pas, S.D., Koopmans, M.P., Middle East respiratory syndrome coronavirus (MERS-CoV) RNA and neutralising antibodies in milk collected according to local customs from dromedary camels, Qatar, April 2014 (2014) Eurosurveillance, 19, p. 20829. , https://doi.org/10.2807/1560-7917.ES2014.19.23.20829; Sikkema, R.S., Farag, E.A.B.A., Islam, M., Atta, M., Reusken, C.B.E.M., Al-Hajri, M.M., Koopmans, M.P.G., Global status of Middle East respiratory syndrome coronavirus in dromedary camels: A systematic review (2019) Epidemiology and Infection, 147. , https://doi.org/10.1017/s095026881800345x; Uerpmann, H.P., Uerpmann, M., The appearance of domestic camel in SE-Arabia (2002) Journal of the Oman Studies, 12, pp. 235-260; (2019) Emergencies: Middle East respiratory syndrome Coronavirus (MERS-CoV), , https://www.who.int/emergencies/mers-cov/en/, Retrieved from; (2019) Emergencies preparedness, response, , https://www.who.int/csr/don/archive/year/en/, Disease outbreaks by year. Retrieved from; Zaki, A.M., van Boheemen, S., Bestebroer, T.M., Osterhaus, A.D.M.E., Fouchier, R.A.M., Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia (2012) New England Journal of Medicine, 367, pp. 1814-1820. , https://doi.org/10.1056/nejmoa1211721","Al-Zahrani, A.; King Faisal Specialist Hospital and Research CentreSaudi Arabia; email: alisaz@kfshrc.edu.sa",,Wiley-VCH Verlag,18631959,,,,English,Zoonoses Public Health,Article,Article in Press,Open Access,Scopus,2-s2.0-85080145108,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Park H.C., Lee S.-H., Kim J., Kim D.H., Cho A., Jeon H.J., Oh J., Noh J.-W., Jeong D.-W., Kim Y.-G., Lee C.-H., Yoo K.D., Lee Y.-K.",34771965700;55890136000;57214593164;57215136490;56506366900;57206189475;8409118400;7102906057;57155802000;54412418300;57215120614;56603636300;55716130600;,Effect of isolation practice on the transmission of middle east respiratory syndrome coronavirus among hemodialysis patients: A 2-year prospective cohort study,2020,Medicine (United States),99,3, e18782,,,,,10.1097/MD.0000000000018782,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078835663&doi=10.1097%2fMD.0000000000018782&partnerID=40&md5=815d3ffa3bd4f530059a40b69c0907c7,"Department of Internal Medicine, Kangnam Sacred Heart Hospital, 1, Singil-ro, Yeongdeungpo-gu, Seoul, South Korea; Hallym University, Kidney Research Institute, Seoul, South Korea; Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, 892, Dongnam-ro, Gangdong-gu, Seoul, South Korea; Department of Internal Medicine, Kangdong Sacred Heart Hospital, Seoul, South Korea; Department of Anesthesiology, Gangneung Medical Center, Gangneung, South Korea; Department of Internal Medicine, Ulsan University Hospital, Ulsan, South Korea","Park, H.C., Department of Internal Medicine, Kangnam Sacred Heart Hospital, 1, Singil-ro, Yeongdeungpo-gu, Seoul, South Korea, Hallym University, Kidney Research Institute, Seoul, South Korea; Lee, S.-H., Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, 892, Dongnam-ro, Gangdong-gu, Seoul, South Korea; Kim, J., Department of Internal Medicine, Kangnam Sacred Heart Hospital, 1, Singil-ro, Yeongdeungpo-gu, Seoul, South Korea; Kim, D.H., Department of Internal Medicine, Kangnam Sacred Heart Hospital, 1, Singil-ro, Yeongdeungpo-gu, Seoul, South Korea, Hallym University, Kidney Research Institute, Seoul, South Korea; Cho, A., Department of Internal Medicine, Kangnam Sacred Heart Hospital, 1, Singil-ro, Yeongdeungpo-gu, Seoul, South Korea, Hallym University, Kidney Research Institute, Seoul, South Korea; Jeon, H.J., Hallym University, Kidney Research Institute, Seoul, South Korea, Department of Internal Medicine, Kangdong Sacred Heart Hospital, Seoul, South Korea; Oh, J., Hallym University, Kidney Research Institute, Seoul, South Korea, Department of Internal Medicine, Kangdong Sacred Heart Hospital, Seoul, South Korea; Noh, J.-W., Department of Internal Medicine, Kangnam Sacred Heart Hospital, 1, Singil-ro, Yeongdeungpo-gu, Seoul, South Korea, Hallym University, Kidney Research Institute, Seoul, South Korea; Jeong, D.-W., Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, 892, Dongnam-ro, Gangdong-gu, Seoul, South Korea; Kim, Y.-G., Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, 892, Dongnam-ro, Gangdong-gu, Seoul, South Korea; Lee, C.-H., Department of Anesthesiology, Gangneung Medical Center, Gangneung, South Korea; Yoo, K.D., Department of Internal Medicine, Ulsan University Hospital, Ulsan, South Korea; Lee, Y.-K., Department of Internal Medicine, Kangnam Sacred Heart Hospital, 1, Singil-ro, Yeongdeungpo-gu, Seoul, South Korea, Hallym University, Kidney Research Institute, Seoul, South Korea","Hemodialysis (HD) patients had a high rate of infection transmission and mortality during the middle east respiratory syndrome coronavirus (MERS-CoV) outbreak in Saudi Arabia. A standardized guideline on isolation technique for exposed HD patients is not available. Thus, this study aimed to evaluate the effect of different isolation strategies on the prevention of secondary viral transmission and clinical outcomes among exposed HD patients.During the 2015 MERS-CoV outbreak in Korea, 116 patients in 3 HD units were incidentally exposed to individuals with confirmed MERS-CoV infection and underwent different types of isolation, which were as follows: single-room isolation (n=54, 47%), cohort isolation (n=46, 40%), and self-imposed quarantine (n=16, 13%). The primary outcome was rate of secondary viral transmission. The secondary outcome measures were changes in clinical and biochemical markers during the isolation period, difference in clinical and biochemical markers according to the types of isolation practice, and effect of isolation practice on patient survival.During a mean isolation period of 15 days, no further cases of secondary transmission were detected among HD patients. Plasma hemoglobin, serum calcium, and serum albumin levels and single-pool Kt/V decreased during the isolation period but normalized thereafter. Patients who were subjected to self-imposed quarantine had higher systolic and diastolic blood pressure, lower total cholesterol level, and lower Kt/V than those who underwent single-room or cohort isolation. During the 24-month follow-up period, 12 patients died. However, none of the deaths occurred during the isolation period, and no differences were observed in patient survival rate according to different isolation strategies.Although 116 participants in 3 HD units were incidentally exposed to MERS-CoV during the 2015 outbreak in Korea, strict patient surveillance and proper isolation practice prevented secondary transmission of the virus. Thus, a renal disaster protocol, which includes proper contact surveillance and isolation practice, must be established in the future to accommodate the needs of HD patients during disasters or outbreaks. © 2020 the Author(s). Published by Wolters Kluwer Health, Inc.",hemodialysis units; isolation; middle east respiratory syndrome coronavirus; quarantine,"calcium; cholesterol; hemoglobin; phosphate; serum albumin; adult; aged; albumin blood level; Article; body mass; body weight change; calcium blood level; cholesterol blood level; clinical outcome; clinical practice; cohort analysis; contact isolation; controlled study; diastolic blood pressure; disease transmission; female; follow up; hemodialysis patient; hemoglobin blood level; human; infection prevention; major clinical study; male; middle aged; Middle East respiratory syndrome; Middle East respiratory syndrome coronavirus; multicenter study; phosphate blood level; priority journal; prospective study; quarantine; survival rate; systolic blood pressure; total cholesterol level; treatment duration; treatment outcome; blood; chronic kidney failure; clinical trial; Coronavirus infection; cross infection; hemodialysis; Middle East respiratory syndrome coronavirus; mortality; patient isolation; procedures; Aged; Coronavirus Infections; Cross Infection; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Middle East Respiratory Syndrome Coronavirus; Patient Isolation; Prospective Studies; Quarantine; Renal Dialysis; Treatment Outcome","Assiri, A., McGeer, A., Peri, T.M., Hospital outbreak of Middle East respiratory syndrome coronavirus (2013) N Engl J Med, 369, pp. 407-416; Middle East respiratory syndrome coronavirus outbreak in the Republic of Korea, 2015 (2015) Osong Public Health Res Perspect, 6, pp. 269-278; Kim, Y.G., Moon, H., Kim, S.Y., Inevitable isolation and the change of stress markers in hemodialysis patients during the 2015 MERS-CoV outbreak in Korea (2019) Sci Rep, 9, p. 5676; Park, H.C., Lee, Y.K., Lee, S.H., Middle East respiratory syndrome clinical practice guideline for hemodialysis facilities (2017) Kidney Res Clin Pract, 36, pp. 111-116; KDOQI clinical practice guidelines for hemodialysis adequacy: 2015 update (2015) Am J Kidney Dis, 66, pp. 884-930; Perera, R.A., Wang, P., Gomaa, M.R., Seroepidemiology for MERS coronavirus using microenutralisation and pseudoparticle virus neutralisation assays reveal a high prevalance of antibody in dromedary camels in Egypt, June 2013 (2013) Euro Surveill, 18, p. 20574; Kopp, J.B., Ball, L.K., Cohen, A., Kidney patients care in disasters: Lessons from the hurricanes and earthquake of 2005 (2007) Clin J Am Soc Nephrol, 2, pp. 814-824; Kopp, J.B., Ball, L.K., Cohen, A., Kidney patient care in disasters: Emergency planning for patients and dialysis facilities (2007) Clin J Am Soc Nephrol, 2, pp. 825-838; Marcelli, D., Marelli, C., Richards, N., Influenza A(H1N1) virus pandemic in the dialysis population: First wave results from an international survey (2009) Nephrol Dial Transplant, 24, pp. 3566-3572; Boyce, J.M., Hymes, J.L., What we learned from Ebola: Preparing dialysis units for the next outbreak (2018) Clin J Am Soc Nephrol, 13, pp. 669-670; Fabrizi, F., Dixit, V., Messa, P., Transmission of hepatitis B virus in dialysis units: A systematic review of reports on outbreaks (2015) Int J Artif Organs, 38, pp. 1-7; Nguyen, D.B., Gutowski, J., Ghiselli, M., A large outbreak of hepatitis C virus infections in a hemodialysis clinic (2016) Infect Control Hosp Epidemiol, 37, pp. 125-133; Park, H.C., Lee, Y.K., Yoo, K.D., Korean clinical practice guidelines for preventing the transmission of infections in hemodialysis facilities (2018) Kidney Res Clin Pract, 37, pp. 8-19; Park, S.W., Perera, R.A., Choe, P.G., Comparison of serological assays in human Middle East respiratory syndrome (MERS)-coronavirus infection (2015) Euro Surveill, 20, p. 30042","Lee, Y.-K.; Department of Internal Medicine, Kangnam Sacred Heart Hospital, 1, Singil-ro, South Korea; email: km2071@naver.com",,Lippincott Williams and Wilkins,257974,,MEDIA,32011472,English,Medicine,Article,Final,Open Access,Scopus,2-s2.0-85078835663,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Jin X., Pang B., Zhang J., Liu Q., Yang Z., Feng J., Liu X., Zhang L., Wang B., Huang Y., Josephine Fauci A., Ma Y., Soo Lee M., Yuan W., Xie Y., Tang J., Gao R., Du L., Zhang S., Qi H., Sun Y., Zheng W., Yang F., Chua H., Wang K., Ou Y., Huang M., Zhu Y., Yu J., Tian J., Zhao M., Hu J., Yao C., Li Y., Zhang B.",57203160513;57215937316;55720332300;57215933293;57215934477;57215931341;57215937136;57215935298;57215932582;57215932161;57215937163;57215932833;57215300699;57216124040;57215837318;57215933624;57215934473;23969019500;57215934256;57215937549;56116732100;36017921400;57200427695;57215935726;57210379374;57215935081;57215937318;57215936109;24171907500;57213429118;57215937289;15071754800;57215935286;55940172300;9634766200;,Core Outcome Set for Clinical Trials on Coronavirus Disease 2019 (COS-COVID),2020,Engineering,,,,,,,,10.1016/j.eng.2020.03.002,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082406730&doi=10.1016%2fj.eng.2020.03.002&partnerID=40&md5=59c5901eab24ec702cf3548982590465,"Evidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Chinese Clinical Trials Core Outcome Set Research Center, Tianjin, 301617, China; Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, 100010, China; The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China; The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300150, China; The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300201, China; Istituto Superiore di Sanità, Rome, 00161, Italy; University of Oxford, Oxford, OX1 3PT, United Kingdom; Korea Institute of Oriental Medicine, Daejeon, 34054, South Korea; Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200120, China; Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China; Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China; Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China; The Chinese Cochrane Center, West China Hospital of Sichuan University, Chengdu, 610041, China; The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China; Suqian People's Hospital of Nanjing Drum-Tower Hospital Group, Suqian, 223800, China; Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Lanzhou University, Lanzhou, 730000, China; The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, 450099, China; Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medicine Science, Beijing, 100700, China; Peking University First Hospital, Beijing, 100034, China","Jin, X., Evidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China, Chinese Clinical Trials Core Outcome Set Research Center, Tianjin, 301617, China; Pang, B., Evidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China, Chinese Clinical Trials Core Outcome Set Research Center, Tianjin, 301617, China; Zhang, J., Evidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China, Chinese Clinical Trials Core Outcome Set Research Center, Tianjin, 301617, China; Liu, Q., Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, 100010, China; Yang, Z., The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510405, China; Feng, J., The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300150, China; Liu, X., The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300201, China; Zhang, L., The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300201, China; Wang, B., The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300150, China; Huang, Y., The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300150, China; Josephine Fauci, A., Istituto Superiore di Sanità, Rome, 00161, Italy; Ma, Y., University of Oxford, Oxford, OX1 3PT, United Kingdom; Soo Lee, M., Korea Institute of Oriental Medicine, Daejeon, 34054, South Korea; Yuan, W., Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200120, China; Xie, Y., Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China; Tang, J., Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, 610075, China; Gao, R., Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China; Du, L., Chinese Clinical Trials Core Outcome Set Research Center, Tianjin, 301617, China, The Chinese Cochrane Center, West China Hospital of Sichuan University, Chengdu, 610041, China; Zhang, S., The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300150, China; Qi, H., The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China; Sun, Y., Suqian People's Hospital of Nanjing Drum-Tower Hospital Group, Suqian, 223800, China; Zheng, W., Evidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China, Chinese Clinical Trials Core Outcome Set Research Center, Tianjin, 301617, China; Yang, F., Evidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China, Chinese Clinical Trials Core Outcome Set Research Center, Tianjin, 301617, China; Chua, H., Evidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China, Chinese Clinical Trials Core Outcome Set Research Center, Tianjin, 301617, China; Wang, K., Evidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China, Chinese Clinical Trials Core Outcome Set Research Center, Tianjin, 301617, China; Ou, Y., Evidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China, Chinese Clinical Trials Core Outcome Set Research Center, Tianjin, 301617, China; Huang, M., Evidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Zhu, Y., Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; Yu, J., Chinese Clinical Trials Core Outcome Set Research Center, Tianjin, 301617, China, The Chinese Cochrane Center, West China Hospital of Sichuan University, Chengdu, 610041, China; Tian, J., Lanzhou University, Lanzhou, 730000, China; Zhao, M., The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, 450099, China; Hu, J., Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medicine Science, Beijing, 100700, China; Yao, C., Peking University First Hospital, Beijing, 100034, China; Li, Y., Chinese Clinical Trials Core Outcome Set Research Center, Tianjin, 301617, China, The Chinese Cochrane Center, West China Hospital of Sichuan University, Chengdu, 610041, China; Zhang, B., Evidence-Based Medicine Center, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China, Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China","Since its outbreak in December 2019, a series of clinical trials on Coronavirus Disease 2019 (COVID-19) have been registered or carried out. However, the significant heterogeneity and less critical outcomes of such trials may be leading to a waste of research resources. This study aimed to develop a core outcome set (COS) for clinical trials on COVID-19 in order to tackle the outcome issues. The study was conducted according to the Core Outcome Measures in Effectiveness Trials (COMET) handbook (version 1.0), a guideline for COS development. A research group was set up that included experts in respiratory and critical medicine, traditional Chinese medicine, evidence-based medicine, clinical pharmacology, and statistics, in addition to medical journal editors. Clinical trial registry websites (chictr.org.cn and clinicaltrials.gov) were searched to retrieve clinical trial protocols and outcomes in order to form an outcome pool. A total of 78 clinical trial protocols on COVID-19 were included and 259 outcomes were collected. After standardization, 132 outcomes were identified within seven different categories, of which 58 were selected to develop a preliminary outcome list for further consensus. After two rounds of Delphi survey and one consensus meeting, the most important outcomes for the different clinical classifications of COVID-19 were identified and determined to constitute the COS for clinical trials on COVID-19 (COS-COVID). The COS-COVID includes one outcome for the mild type (time to 2019-nCoV reverse transcription-polymerase chain reaction (RT-PCR) negativity), four outcomes for the ordinary type (length of hospital stay, composite events, score of clinical symptoms, and time to 2019-nCoV RT-PCR negativity), five outcomes for the severe type (composite events, length of hospital stay, arterial oxygen partial pressure (PaO2)/fraction of inspired oxygen (FiO2), duration of mechanical ventilation, and time to 2019-nCoV RT-PCR negativity), one outcome for critical type (all-cause mortality), and one outcome for rehabilitation period (pulmonary function). The COS-COVID is currently the most valuable and practical clinical outcome set for the evaluation of intervention effect, and is useful for evidence assessment and decision-making. With a deepening understanding of COVID-19 and application feedback, the COS-COVID should be continuously updated. © 2020",2019-nCoV; Clinical trials; Core outcome set; Coronavirus disease; COVID-19,Decision making; Hospitals; Medical applications; Oxygen; Polymerase chain reaction; Ventilation; 2019-nCoV; Clinical trial; Coronaviruses; COVID-19; Outcome sets; Clinical research,"Sinha, I.P., Gallagher, R., Williamson, P.R., Smyth, R.L., Development of a core outcome set for clinical trials in childhood asthma: a survey of clinicians, parents, and young people (2012) Trials, 13 (1), p. 103; Williamson, P.R., Altman, D.G., Blazeby, J.M., Clarke, M., Gargon, E., Driving up the quality and relevance of research through the use of agreed core outcomes (2012) J Health Serv Res Policy, 17 (1), pp. 1-2; Xing, D.M., Zhang, J.H., Zhang, B.L., Approach to developing core outcome sets for clinical trials of traditional Chinese medicine (2014) Chin J Tradit Chin Med Pharm, 29 (5), pp. 1352-1355; Williamson, P.R., Altman, D.G., Blazeby, J.M., Clarke, M., Devane, D., Gargon, E., Developing core outcome sets for clinical trials: issues to consider (2012) Trials, 13 (1), p. 132; Williamson, P.R., Altman, D.G., Bagley, H., Barnes, K.L., Blazeby, J.M., Brookes, S.T., The COMET handbook: version 1.0 (2017) Trials, 18, p. 280; Kirkham, J.J., Davis, K., Altman, D.G., Blazeby, J.M., Clarke, M., Tunis, S., Core outcome Set-STAndards for development: the COS-STAD recommendations (2017) PLoS Med, 14 (11). , e1002447; Kirkham, J.J., Gorst, S., Altman, D.G., Blazeby, J.M., Clarke, M., Devane, D., Core outcome set-STAndards for reporting: the COS-STAR statement (2016) PLoS Med, 13 (10). , e1002148; Kirkham, J.J., Gorst, S., Altman, D.G., Blazeby, J.M., Clarke, M., Tunis, S., Core outcome Set-STAndardised protocol items: the COS-STAP statement (2019) Trials, 20 (1), p. 116; National Health Commission of the People's Republic of China. Diagnosis and treatment plan of corona virus disease 2019 (tentative 6th edition). 2020 Feb 18. Chinese","Zhang, J.; Evidence-Based Medicine Center, Tianjin University of Traditional Chinese MedicineChina; email: zjhtcm@foxmail.com",,Elsevier Ltd,20958099,,,,English,Engineering,Article,Article in Press,Open Access,Scopus,2-s2.0-85082406730,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Bouwman K.M., Parsons L.M., Berends A.J., De Vries R.P., Cipollo J.F., Verheije M.H.",57193003445;56019454900;57194493485;36458043300;6603068791;7801561319;,Three amino acid changes in avian coronavirus spike protein allow binding to kidney tissue,2020,Journal of Virology,94,2, e01363-19,,,,,10.1128/JVI.01363-19,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077668187&doi=10.1128%2fJVI.01363-19&partnerID=40&md5=f0d76e588f3d81eb35a1258bfdbb8451,"Division of Pathology, Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands; Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, United States; Department of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands","Bouwman, K.M., Division of Pathology, Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands; Parsons, L.M., Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, United States; Berends, A.J., Division of Pathology, Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands; De Vries, R.P., Department of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands; Cipollo, J.F., Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, United States; Verheije, M.H., Division of Pathology, Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands","Infectious bronchitis virus (IBV) infects ciliated epithelial cells in the chicken respiratory tract. While some IBV strains replicate locally, others can disseminate to various organs, including the kidney. Here, we elucidate the determinants for kidney tropism by studying interactions between the receptor-binding domain (RBD) of the viral attachment protein spike from two IBV strains with different tropisms. Recombinantly produced RBDs from the nephropathogenic IBV strain QX and from the nonnephropathogenic strain M41 bound to the epithelial cells of the trachea. In contrast, only QX-RBD binds more extensively to cells of the digestive tract, urogenital tract, and kidneys. While removal of sialic acids from tissues prevented binding of all proteins to all tissues, binding of QX-RBD to trachea and kidney could not be blocked by preincubation with synthetic alpha-2,3-linked sialic acids. The lack of binding of QX-RBD to a previously identified IBV-M41 receptor was confirmed by enzyme-linked immunosorbent assay (ELISA), demonstrating that tissue binding of QX-RBD is dependent on a different sialylated glycan receptor. Using chimeric RBD proteins, we discovered that the region encompassing amino acids 99 to 159 of QX-RBD was required to establish kidney binding. In particular, QX-RBD amino acids 110 to 112 (KIP) were sufficient to render IBV-M41 with the ability to bind to kidney, while the reciprocal mutations in IBV-QX abolished kidney binding completely. Structural analysis of both RBDs suggests that the receptor-binding site for QX is located at a different location on the spike than that of M41. IMPORTANCE Infectious bronchitis virus is the causative agent of infectious bronchitis in chickens. Upon infection of chicken flocks, the poultry industry faces substantial economic losses by diminished egg quality and increased morbidity and mortality of infected animals. While all IBV strains infect the chicken respiratory tract via the ciliated epithelial layer of the trachea, some strains can also replicate in the kidneys, dividing IBV into the following two pathotypes: nonnephropathogenic (example, IBV-M41) and nephropathogenic viruses (including IBV-QX). Here, we set out to identify the determinants for the extended nephropathogenic tropism of IBV-QX. Our data reveal that each pathotype makes use of a different sialylated glycan ligand, with binding sites on opposite sides of the attachment protein. This knowledge should facilitate the design of antivirals to prevent coronavirus infections in the field. Copyright © 2020 Bouwman et al.",Coronavirus; Infectious bronchitis virus; Receptor-binding domain; Receptors; Spike protein; Virus-host interactions,amino acid; sialic acid; viral protein; Article; Avian infectious bronchitis virus; controlled study; enzyme linked immunosorbent assay; epithelium cell; human; human cell; kidney tissue; mutation; nonhuman; priority journal; protein analysis; protein binding; protein domain; protein structure; tropism; virus strain,"Peighambari, S.M., Julian, R.J., Gyles, C.L., Experimental Escherichia coli respiratory infection in broilers (2000) Avian Dis, 44, pp. 759-769. , https://doi.org/10.2307/1593047; De Wit, J.J., Cazaban, C., Dijkman, R., Ramon, G., Gardin, Y., Detection of different genotypes of infectious bronchitis virus and of infectious bursal disease virus in European broilers during an epidemiological study in 2013 and the consequences for the diagnostic approach (2018) Avian Pathol, 47, pp. 140-151. , https://doi.org/10.1080/03079457.2017.1387231; Valastro, V., Holmes, E.C., Britton, P., Fusaro, A., Jackwood, M.W., Cattoli, G., Monne, I., S1 gene-based phylogeny of infectious bronchitis virus: An attempt to harmonize virus classification (2016) Infect Genet Evol, 39, pp. 349-364. , https://doi.org/10.1016/j.meegid.2016.02.015; Shen, C.I., Wang, C.H., Liao, J.W., Hsu, T.W., Kuo, S.M., Su, H.L., The infection of primary avian tracheal epithelial cells with infectious bronchitis virus (2010) Vet Res, 41, p. 6. , https://doi.org/10.1051/vetres/2009054; Abd El Rahman, S., El-Kenawy, A.A., Neumann, U., Herrler, G., Winter, C., Comparative analysis of the sialic acid binding activity and the tropism for the respiratory epithelium of four different strains of avian infectious bronchitis virus (2009) Avian Pathol, 38, pp. 41-45. , https://doi.org/10.1080/03079450802632049; Armesto, M., Cavanagh, D., Britton, P., The replicase gene of avian coronavirus infectious bronchitis virus is a determinant of pathogenicity (2009) PLoS One, 4. , https://doi.org/10.1371/journal.pone.0007384; Bande, F., Arshad, S.S., Omar, A.R., Hair-Bejo, M., Mahmuda, A., Nair, V., Global distributions and strain diversity of avian infectious bronchitis virus: A review (2017) Anim Health Res Rev, 18, pp. 70-83. , https://doi.org/10.1017/S1466252317000044; Gough, R.E., Cox, W.J., Welchman, D.B., Worthington, K.J., Jones, R.C., Chinese QX strain of infectious bronchitis virus isolated in the UK (2008) Vet Rec, 162, pp. 99-100. , https://doi.org/10.1136/vr.162.3.99; Benyeda, Z., Szeredi, L., Mato, T., Suveges, T., Balka, G., Abonyi-Toth, Z., Rusvai, M., Palya, V., Comparative histopathology and immunohistochem-istry of QX-like, Massachusetts and 793/B serotypes of infectious bronchitis virus infection in chickens (2010) J Comp Pathol, 143, pp. 276-283. , https://doi.org/10.1016/j.jcpa.2010.04.007; Raj, G.D., Jones, R.C., Infectious bronchitis virus: Immunopathogenesis of infection in the chicken (1997) Avian Pathol, 26, pp. 677-706. , https://doi.org/10.1080/03079459708419246; Villarreal, L.Y., Brandao, P.E., Chacon, J.L., Saidenberg, A.B., Assayag, M.S., Jones, R.C., Ferreira, A.J., Molecular characterization of infectious bronchitis virus strains isolated from the enteric contents of Brazilian laying hens and broilers (2007) Avian Dis, 51, pp. 974-978. , https://doi.org/10.1637/7983-041307.1; Yudong, W., Yonglin, W., Zichun, Z., Genche, F., Yihai, J., Xiange, L., Jiang, D., Shushuang, W., Isolation and identification of glandular stomach type IBV (QX IBV) in chickens (1998) Chinese J Anim Quarantine, 15, pp. 1-3; Yu, L., Jiang, Y., Low, S., Wang, Z., Nam, S.J., Liu, W., Kwangac, J., Characterization of three infectious bronchitis virus isolates from China associated with proventriculus in vaccinated chickens (2001) Avian Dis, 45, pp. 416-424. , https://doi.org/10.2307/1592981; Liu, S., Kong, X., A new genotype of nephropathogenic infectious bronchitis virus circulating in vaccinated and non-vaccinated flocks in China (2004) Avian Pathol, 33, pp. 321-327. , https://doi.org/10.1080/0307945042000220697; Promkuntod, N., Van Eijndhoven, R.E.W., De Vrieze, G., Gröne, A., Verheije, M.H., Mapping of the receptor-binding domain and amino acids critical for attachment in the spike protein of avian coronavirus infectious bronchitis virus (2014) Virology, 448, pp. 26-32. , https://doi.org/10.1016/j.virol.2013.09.018; Leyson, C., Franca, M., Jackwood, M., Jordan, B., Polymorphisms in the S1 spike glycoprotein of Arkansas-type infectious bronchitis virus (IBV) show differential binding to host tissues and altered antigenicity (2016) Virology, 498, pp. 218-225. , https://doi.org/10.1016/j.virol.2016.08.030; Parsons, L.M., Bouwman, K.M., Azurmendi, H., De Vries, R.P., Cipollo, J.F., Verheije, M.H., Glycosylation of the viral attachment protein of avian coronavirus is essential for host cell and receptor binding (2019) J Biol Chem, 294, pp. 7797-7809. , https://doi.org/10.1074/jbc.RA119.007532; Casais, R., Dove, B., Cavanagh, D., Britton, P., Recombinant avian infectious bronchitis virus expressing a heterologous spike gene demonstrates that the spike protein is a determinant of cell tropism (2003) J Virol, 77, pp. 9084-9089. , https://doi.org/10.1128/jvi.77.16.9084-9089.2003; Wickramasinghe, I.N., De Vries, R.P., Grone, A., De Haan, C.A., Verheije, M.H., Binding of avian coronavirus spike proteins to host factors reflects virus tropism and pathogenicity (2011) J Virol, 85, pp. 8903-8912. , https://doi.org/10.1128/JVI.05112-11; Shang, J., Zheng, Y., Yang, Y., Liu, C., Geng, Q., Luo, C., Zhang, W., Li, F., Cryo-EM structure of infectious bronchitis coronavirus spike protein reveals structural and functional evolution of coronavirus spike proteins (2018) PLoS Pathog, 14. , https://doi.org/10.1371/journal.ppat.1007009; Promkuntod, N., Wickramasinghe, I.N., De Vrieze, G., Grone, A., Verheije, M.H., Contributions of the S2 spike ectodomain to attachment and host range of infectious bronchitis virus (2013) Virus Res, 177, pp. 127-137. , https://doi.org/10.1016/j.virusres.2013.09.006; Niesters, H.G., Lenstra, J.A., Spaan, W.J., Zijderveld, A.J., Bleumink-Pluym, N.M., Hong, F., Van Scharrenburg, G.J., Van Der Zeijst, B.A., The peplomer protein sequence of the M41 strain of coronavirus IBV and its comparison with Beaudette strains (1986) Virus Res, 5, pp. 253-263. , https://doi.org/10.1016/0168-1702(86)90022-5; Whitmore, L., Wallace, B.A., Protein secondary structure analyses from circular dichroism spectroscopy: Methods and reference databases (2008) Biopolymers, 89, pp. 392-400. , https://doi.org/10.1002/bip.20853; Wickramasinghe, I.N.A., De Vries, R.P., Eggert, A.M., Wandee, N., De Haan, C.A.M., Gröne, A., Verheije, M.H., Host tissue and glycan binding specificities of avian viral attachment proteins using novel avian tissue microarrays (2015) PLoS One, 10. , https://doi.org/10.1371/journal.pone.0128893; Bouwman, K.M., Delpont, M., Broszeit, F., Berger, R., Weerts, E., Lucas, M.N., Delverdier, M., Verheije, M.H., Guinea fowl coronavirus diversity has phenotypic consequences for glycan and tissue binding (2019) J Virol, 93, pp. e00067-e00119. , https://doi.org/10.1128/JVI.00067-19; Ambepitiya Wickramasinghe, I.N., De Vries, R.P., Weerts, E.A.W.S., Van Beurden, S.J., Peng, W., McBride, R., Ducatez, M., Verheije, M.H., Novel receptor specificity of avian gammacoronaviruses that cause enteritis (2015) J Virol, 89, pp. 8783-8792. , https://doi.org/10.1128/JVI.00745-15; Schultze, B., Krempl, C., Ballesteros, M.L., Shaw, L., Schauer, R., Enjuanes, L., Herrler, G., Transmissible gastroenteritis coronavirus, but not the related porcine respiratory coronavirus, has a sialic acid (N-glycolylneuraminic acid) binding activity (1996) J Virol, 70, pp. 5634-5637; Liu, C., Tang, J., Ma, Y., Liang, X., Yang, Y., Peng, G., Qi, Q., Li, F., Receptor usage and cell entry of porcine epidemic diarrhea coronavirus (2015) J Virol, 89, pp. 6121-6125. , https://doi.org/10.1128/JVI.00430-15; Bakkers, M.J., Lang, Y., Feitsma, L.J., Hulswit, R.J., De Poot, S.A., Van Vliet, A.L., Margine, I., De Groot, R.J., Betacoronavirus adaptation to humans involved progressive loss of hemagglutinin-esterase lectin activity (2017) Cell Host Microbe, 21, pp. 356-366. , https://doi.org/10.1016/j.chom.2017.02.008; Peng, W., De Vries, R.P., Grant, O.C., Thompson, A.J., McBride, R., Tsogtbaatar, B., Lee, P.S., Paulson, J.C., Recent H3N2 viruses have evolved specificity for extended, branched human-type receptors, conferring potential for increased avidity (2017) Cell Host Microbe, 21, pp. 23-34. , https://doi.org/10.1016/j.chom.2016.11.004; Broszeit, F., Tzarum, N., Zhu, X., Nemanichvili, N., Eggink, D., Leenders, T., Li, Z., De Vries, R.P., N-glycolylneuraminic acid as a receptor for influenza A viruses (2019) Cell Rep, 27, pp. 3284-3294. , https://doi.org/10.1016/j.celrep.2019.05.048; Manavalan, P., Johnson, W.C., Jr., Variable selection method improves the prediction of protein secondary structure from circular dichroism spectra (1987) Anal Biochem, 167, pp. 76-85. , https://doi.org/10.1016/0003-2697(87)90135-7; Sreerama, N., Woody, R.W., A self-consistent method for the analysis of protein secondary structure from circular dichroism (1993) Anal Biochem, 209, pp. 32-44. , https://doi.org/10.1006/abio.1993.1079; Van Stokkum, I.H., Spoelder, H.J., Bloemendal, M., Van Grondelle, R., Groen, F.C., Estimation of protein secondary structure and error analysis from circular dichroism spectra (1990) Anal Biochem, 191, pp. 110-118. , https://doi.org/10.1016/0003-2697(90)90396-q","Bouwman, K.M.; Division of Pathology, Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht UniversityNetherlands; email: k.m.bouwman@uu.nl",,American Society for Microbiology,0022538X,,JOVIA,31694947,English,J. Virol.,Article,Final,Open Access,Scopus,2-s2.0-85077668187,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhu W., Xie K., Lu H., Xu L., Zhou S., Fang S.",57214219282;57215860309;57215861669;57199907286;12802769700;16834521200;,"Initial clinical features of suspected coronavirus disease 2019 in two emergency departments outside of Hubei, China",2020,Journal of Medical Virology,,,,,,,,10.1002/jmv.25763,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082109654&doi=10.1002%2fjmv.25763&partnerID=40&md5=0f354065dc75cb7875ba0a9fe6a6dc71,"Department of Emergency, The First Affiliated Hospital of University of Science and Technology of China, Hefei, China; Department of Emergency, Affiliated Anhui Provincial Hospital of Anhui Medical University, Hefei, China; Department of Nursing, The First Affiliated Hospital of University of Science and Technology of China, Hefei, China; Department of ICU, The First Affiliated Hospital of University of Science and Technology of China, Hefei, China","Zhu, W., Department of Emergency, The First Affiliated Hospital of University of Science and Technology of China, Hefei, China, Department of Emergency, Affiliated Anhui Provincial Hospital of Anhui Medical University, Hefei, China; Xie, K., Department of Emergency, The First Affiliated Hospital of University of Science and Technology of China, Hefei, China; Lu, H., Department of Emergency, The First Affiliated Hospital of University of Science and Technology of China, Hefei, China, Department of Nursing, The First Affiliated Hospital of University of Science and Technology of China, Hefei, China; Xu, L., Department of Emergency, The First Affiliated Hospital of University of Science and Technology of China, Hefei, China; Zhou, S., Department of Emergency, The First Affiliated Hospital of University of Science and Technology of China, Hefei, China, Department of ICU, The First Affiliated Hospital of University of Science and Technology of China, Hefei, China; Fang, S., Department of Emergency, The First Affiliated Hospital of University of Science and Technology of China, Hefei, China, Department of Emergency, Affiliated Anhui Provincial Hospital of Anhui Medical University, Hefei, China","With an increasing number of Coronavirus Disease 2019 (COVID-19) cases outside of Hubei, emergency departments (EDs) and fever clinics are facing challenges posed by the large number of admissions of patients suspected to have COVID-19. Therefore, it is of crucial importance to study the initial clinical features of patients, to better differentiate between infected and uninfected patients outside Hubei. A total of 116 patients suspected of having COVID-19 who presented to two emergency departments in Anhui for the first time between 24 January 2020 and 20 February 2020 were enrolled in the study. The initial clinical data of these patients, such as epidemiological features, symptoms, laboratory results, and chest computed tomography (CT) findings were collected using a standard case report form on admission. Thirty-two patients were diagnosed with COVID-19; the remaining 84 patients were referred to as negative cases. The median age of the diagnosed patients was 46 years, but only 35 years for negative cases. History of exposure to Wuhan or COVID-19 patients in the previous 2 weeks was observed in 63% of the diagnosed and 44% of negative cases. Median time from illness onset to ED admission was 5 days for all patients, diagnosed patients, and negative cases, respectively. Fever was observed in 27 (84%) and 57 (68%) diagnosed and negative cases, respectively. Nineteen (59%) diagnosed and 24 (29%) negative cases had lymphopenia on admission in ED. A chest CT scan on admission revealed the presence of pneumonia in the majority of the diagnosed patients (30 out of 32, 94%) and in 56 (67%) negative cases. Bilateral involvement and ground-glass opacity (GGO) were present in 91% and 47% of the diagnosed patients. Thirty-two patients were diagnosed with COVID-19; the remaining 84 patients were referred to as negative cases. The median age of the diagnosed patients was 46 years, but only 35 years for negative cases. History of exposure to Wuhan or COVID-19 patients in the previous 2 weeks was observed in 63% of the diagnosed and 44% of negative cases. Median time from illness onset to ED admission was 5 days for all patients, diagnosed patients, and negative cases, respectively. Fever was observed in 27 (84%) and 57 (68%) diagnosed and negative cases, respectively. Nineteen (59%) diagnosed and 24 (29%) negative cases had lymphopenia on admission in ED. A chest CT scan on admission revealed the presence of pneumonia in the majority of the diagnosed patients (30 out of 32, 94%) and in 56 (67%) negative cases. Bilateral involvement and GGO were present in 91% and 47% of the diagnosed patients. © 2020 Wiley Periodicals, Inc.",coronavirus; epidemiology; infection; virus classification,,"Clinical management of severe acute respiratory infection when Novel coronavirus (nCoV) infection is suspected: interim guidance, , https://wwwwhoint/publications-detail/clinical-management-of-severe-acute-respiratory-infection-whennovel-coronavirus-(ncov)-infection-is-suspected, Accessed January 12, 2020; Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382 (8), pp. 727-733; Wang, D., Hu, B., Hu, C., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) JAMA., , https://doi.org/10.1001/jama.2020.1585; Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia N Engl J Med, , https://doi.org/10.1056/NEJMoa2001316, [published online ahead of print January 29, 2020]; Lu, R., Zhao, X., Li, J., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet, 395 (10224), pp. 565-574; Chan, J.F.-W., Yuan, S., Kok, K.-H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, 395 (10223), pp. 514-523; Pan, X., Chen, D., Xia, Y., Asymptomatic cases in a family cluster with SARS-CoV-2 infection Lancet Infect Dis, , https://doi.org/10.1016/S1473-3099(20)30114-6, [published online ahead of print February 19, 2020]; Albarello, F., Pianura, E., Di Stefano, F., 2019-Novel coronavirus severe adult respiratory distress syndrome in two cases in Italy: an uncommon radiological presentation (2020) Int J Infect Dis, 93, pp. 2020-2197; Zhang, S., Diao, M., Yu, W., Pei, L., Lin, Z., Chen, D., Estimation of the reproductive number of Novel Coronavirus (COVID-19) and the probable outbreak size on the Diamond Princess cruise ship: a data-driven analysis (2020) Int J Infect Dis, 93, pp. 201-204; Lai, C.C., Shih, T.P., Ko, W.C., Tang, H.J., Hsueh, P.R., Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): the epidemic and the challenges (2020) Int J Antimicrob Agents, 55; Xu, X.W., Wu, X.X., Jiang, X.G., Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series (2020) BMJ, 368; Pan, F., Ye, T., Sun, P., Time course of lung changes on chest CT during recovery from 2019 novel coronavirus (COVID-19) pneumonia Radiology, , https://doi.org/10.1148/radiol.2020200370, [published online ahead of print February 13, 2020]; http://wwwnhcgovcn/yzygj/s7653p/202001/f492c9153ea9437bb587ce2ffcbee1fashtml, Diagnosis and treatment of pneumonia caused by novel coronavirus infection (trial version III)., Accessed January 23, 2020; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395 (10223), pp. 497-506; Guan, W., Ni, Z., Hu, Y., Clinical characteristics of coronavirus disease 2019 in China N Engl J Med, , https://doi.org/10.1056/NEJMoa2002032, [published online ahead of print February 28, 2020]; Xia, J., Tong, J., Liu, M., Shen, Y., Guo, D., Evaluation of coronavirus in tears and conjunctival secretions of patients with SARS-CoV-2 infection J Med Virol, , https://doi.org/10.1002/jmv.25725, [published online ahead of print February 26, 2020]; Wu, J., Wu, X., Zeng, W., Chest CT findings in patients with corona virus disease 2019 and its relationship with clinical features Invest Radiol, , https://doi.org/10.1097/RLI.0000000000000670, [published online ahead of print February 21, 2020]; Ai, T., Yang, Z., Hou, H., Correlation of chest CT and RT-PCR testing in coronavirus disease 2019 (COVID-19) in China: a report of 1014 cases Radiology, , https://doi.org/10.1148/radiol.2020200642, [published online ahead of print February 26, 2020]; Shi, H., Han, X., Jiang, N., Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study Lancet Infect Dis, , https://doi.org/10.1016/S1473-3099(20)30086-4, [published online ahead of print February 24, 2020]; Wilder-Smith, A., Freedman, D.O., Isolation, quarantine, social distancing and community containment: pivotal role for old-style public health measures in the novel coronavirus (2019-nCoV) outbreak (2020) J Travel Med, 27 (2); Brooks, S.K., Webster, R.K., Smith, L.E., The psychological impact of quarantine and how to reduce it: rapid review of the evidence (2020) Lancet, 395 (10227), pp. P912-P920","Xu, L.; Department of Emergency, The First Affiliated Hospital of University of Science and Technology of ChinaChina; email: bayinhexl@126.com",,John Wiley and Sons Inc.,1466615,,JMVID,32167181,English,J. Med. Virol.,Article,Article in Press,Open Access,Scopus,2-s2.0-85082109654,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wu C., Chen X., Cai Y., Xia J., Zhou X., Xu S., Huang H., Zhang L., Zhou X., Du C., Zhang Y., Song J., Wang S., Chao Y., Yang Z., Xu J., Zhou X., Chen D., Xiong W., Xu L., Zhou F., Jiang J., Bai C., Zheng J., Song Y.",57191753582;57215690938;57215688686;57214460628;57215682997;57215682012;57215683907;57202313986;57215683014;57215692206;57215700427;57215683347;57215697751;57215688831;57215687241;57215684230;57215682871;55724974400;57215693702;57215684379;57215690879;7404829542;7201686228;55710039400;7404920196;,"Risk Factors Associated with Acute Respiratory Distress Syndrome and Death in Patients with Coronavirus Disease 2019 Pneumonia in Wuhan, China",2020,JAMA Internal Medicine,,,,,,,3,10.1001/jamainternmed.2020.0994,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081683293&doi=10.1001%2fjamainternmed.2020.0994&partnerID=40&md5=ac099e7fdae821edd1a7983519bc6fc4,"Department of Pulmonary Medicine, QingPu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai, China; Infection Division, Wuhan Jinyintan Hospital, Wuhan, China; Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China; Tuberculosis and Respiratory Department, Wuhan Jinyintan Hospital, Wuhan, China; Department of Anesthesiology, Intl. Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Infectious Diseases, Fengxian Guhua Hospital, Shanghai, China; Department of Pulmonary Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Respiratory Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Emergency Medicine, Shanghai Pudong New Area Gongli Hospital, Shanghai, China; Shanghai Respiratory Research Institute, Shanghai, China; Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China","Wu, C., Department of Pulmonary Medicine, QingPu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai, China, Infection Division, Wuhan Jinyintan Hospital, Wuhan, China, Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China; Chen, X., Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China; Cai, Y., Infection Division, Wuhan Jinyintan Hospital, Wuhan, China; Xia, J., Tuberculosis and Respiratory Department, Wuhan Jinyintan Hospital, Wuhan, China; Zhou, X., Infection Division, Wuhan Jinyintan Hospital, Wuhan, China; Xu, S., Infection Division, Wuhan Jinyintan Hospital, Wuhan, China; Huang, H., Tuberculosis and Respiratory Department, Wuhan Jinyintan Hospital, Wuhan, China; Zhang, L., Tuberculosis and Respiratory Department, Wuhan Jinyintan Hospital, Wuhan, China; Zhou, X., Tuberculosis and Respiratory Department, Wuhan Jinyintan Hospital, Wuhan, China; Du, C., Department of Pulmonary Medicine, QingPu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai, China; Zhang, Y., Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China; Song, J., Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China; Wang, S., Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China; Chao, Y., Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China; Yang, Z., Department of Anesthesiology, Intl. Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Xu, J., Department of Infectious Diseases, Fengxian Guhua Hospital, Shanghai, China; Zhou, X., Department of Pulmonary Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Chen, D., Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Xiong, W., Department of Respiratory Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Xu, L., Department of Emergency Medicine, Shanghai Pudong New Area Gongli Hospital, Shanghai, China; Zhou, F., Department of Pulmonary Medicine, QingPu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai, China; Jiang, J., Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China; Bai, C., Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China, Shanghai Respiratory Research Institute, Shanghai, China; Zheng, J., Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Song, Y., Department of Pulmonary Medicine, QingPu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai, China, Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China, Shanghai Respiratory Research Institute, Shanghai, China, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China","Importance: Coronavirus disease 2019 (COVID-19) is an emerging infectious disease that was first reported in Wuhan, China, and has subsequently spread worldwide. Risk factors for the clinical outcomes of COVID-19 pneumonia have not yet been well delineated. Objective: To describe the clinical characteristics and outcomes in patients with COVID-19 pneumonia who developed acute respiratory distress syndrome (ARDS) or died. Design, Setting, and Participants: Retrospective cohort study of 201 patients with confirmed COVID-19 pneumonia admitted to Wuhan Jinyintan Hospital in China between December 25, 2019, and January 26, 2020. The final date of follow-up was February 13, 2020. Exposures: Confirmed COVID-19 pneumonia. Main Outcomes and Measures: The development of ARDS and death. Epidemiological, demographic, clinical, laboratory, management, treatment, and outcome data were also collected and analyzed. Results: Of 201 patients, the median age was 51 years (interquartile range, 43-60 years), and 128 (63.7%) patients were men. Eighty-four patients (41.8%) developed ARDS, and of those 84 patients, 44 (52.4%) died. In those who developed ARDS, compared with those who did not, more patients presented with dyspnea (50 of 84 [59.5%] patients and 30 of 117 [25.6%] patients, respectively [difference, 33.9%; 95% CI, 19.7%-48.1%]) and had comorbidities such as hypertension (23 of 84 [27.4%] patients and 16 of 117 [13.7%] patients, respectively [difference, 13.7%; 95% CI, 1.3%-26.1%]) and diabetes (16 of 84 [19.0%] patients and 6 of 117 [5.1%] patients, respectively [difference, 13.9%; 95% CI, 3.6%-24.2%]). In bivariate Cox regression analysis, risk factors associated with the development of ARDS and progression from ARDS to death included older age (hazard ratio [HR], 3.26; 95% CI 2.08-5.11; and HR, 6.17; 95% CI, 3.26-11.67, respectively), neutrophilia (HR, 1.14; 95% CI, 1.09-1.19; and HR, 1.08; 95% CI, 1.01-1.17, respectively), and organ and coagulation dysfunction (eg, higher lactate dehydrogenase [HR, 1.61; 95% CI, 1.44-1.79; and HR, 1.30; 95% CI, 1.11-1.52, respectively] and D-dimer [HR, 1.03; 95% CI, 1.01-1.04; and HR, 1.02; 95% CI, 1.01-1.04, respectively]). High fever (≥39 °C) was associated with higher likelihood of ARDS development (HR, 1.77; 95% CI, 1.11-2.84) and lower likelihood of death (HR, 0.41; 95% CI, 0.21-0.82). Among patients with ARDS, treatment with methylprednisolone decreased the risk of death (HR, 0.38; 95% CI, 0.20-0.72). Conclusions and Relevance: Older age was associated with greater risk of development of ARDS and death likely owing to less rigorous immune response. Although high fever was associated with the development of ARDS, it was also associated with better outcomes among patients with ARDS. Moreover, treatment with methylprednisolone may be beneficial for patients who develop ARDS. © 2020 American Medical Association. All rights reserved.",,,"https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200226-sitrep-37-covid-19.pdf?sfvrsn=6126c0a4_2, Coronavirus disease 2019 (COVID-19): Situation report-37. February 25, 2020. 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Posted online January 31, 2020. bioRxiv. doi; Gu, J., Gong, E., Zhang, B., Multiple organ infection and the pathogenesis of SARS (2005) J Exp Med, 202 (3), pp. 415-424. , http://dx.doi.org/10.1084/jem.20050828, doi: PMID 16043521; Li, T., Qiu, Z., Zhang, L., Significant changes of peripheral T lymphocyte subsets in patients with severe acute respiratory syndrome (2004) J Infect Dis, 189 (4), pp. 648-651. , http://dx.doi.org/10.1086/381535, doi: PMID 14767818; Cui, W., Fan, Y., Wu, W., Zhang, F., Wang, J.Y., Ni, A.P., Expression of lymphocytes and lymphocyte subsets in patients with severe acute respiratory syndrome (2003) Clin Infect Dis, 37 (6), pp. 857-859. , http://dx.doi.org/10.1086/378587, doi: PMID 12955652; Kim, K.D., Zhao, J., Auh, S., Adaptive immune cells temper initial innate responses (2007) Nat Med, 13 (10), pp. 1248-1252. , http://dx.doi.org/10.1038/nm1633, doi: PMID 17891146; Zhao, J., Zhao, J., Perlman, S., T cell responses are required for protection from clinical disease and for virus clearance in severe acute respiratory syndrome coronavirus-infected mice (2010) J Virol, 84 (18), pp. 9318-9325. , http://dx.doi.org/10.1128/JVI.01049-10, doi: PMID 20610717","Song, Y.; Department of Pulmonary and Critical Care Medicine, Fudan University, Zhongshan Hospital, 180 Fenglin Rd, China; email: ylsong70_02@163.com",,American Medical Association,21686106,,,32167524,English,JAMA Intern. Med.,Article,Article in Press,Open Access,Scopus,2-s2.0-85081683293,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Li X., Geng M., Peng Y., Meng L., Lu S.",57215825216;56480133700;57215811391;8718207500;57208830728;,Molecular immune pathogenesis and diagnosis of COVID-19,2020,Journal of Pharmaceutical Analysis,,,,,,,1,10.1016/j.jpha.2020.03.001,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081948804&doi=10.1016%2fj.jpha.2020.03.001&partnerID=40&md5=2e909ca1371bb12c5da9d0d36f6aa1e1,"Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi 710061, China; Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an, Shaanxi 710061, China","Li, X., Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi 710061, China, Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an, Shaanxi 710061, China; Geng, M., Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi 710061, China, Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an, Shaanxi 710061, China; Peng, Y., Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi 710061, China, Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an, Shaanxi 710061, China; Meng, L., Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi 710061, China, Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an, Shaanxi 710061, China; Lu, S., Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi 710061, China, Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an, Shaanxi 710061, China","Coronavirus disease 2019 (COVID-19) is a kind of viral pneumonia with an unusual outbreak in Wuhan, China, in December 2019, which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The emergence of SARS-CoV-2 has been marked as the third introduction of a highly pathogenic coronavirus into the human population after the severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV) in the twenty-first century. In this minireview, we provide a brief introduction of the general features of SARS-CoV-2 and discuss current knowledge of molecular immune pathogenesis, diagnosis and treatment of COVID-19 on the base of the present understanding of SARS-CoV and MERS-CoV infections, which may be helpful in offering novel insights and potential therapeutic targets for combating the SARS-CoV-2 infection. © 2020 Xi'an Jiaotong University",Coronavirus; MERS-CoV; Pathogenesis; SARS-CoV; SARS-CoV-2,,"Zhou, P., Yang, X.L., Wang, X.G., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature; de Wit, E., van Doremalen, N., Falzarano, D., SARS and MERS: recent insights into emerging coronaviruses (2016) Nat. Rev. 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Bull., 35, pp. 2036-2042; Mair-Jenkins, J., Saavedra-Campos, M., Baillie, J.K., The effectiveness of convalescent plasma and hyperimmune immunoglobulin for the treatment of severe acute respiratory infections of viral etiology: a systematic review and exploratory meta-analysis (2015) J. Infect. Dis., 211, pp. 80-90; Koenig, K.L., Identify-Isolate-Inform: a modified tool for initial detection and management of Middle East Respiratory Syndrome patients in the emergency department (2015) West. J. Emerg. Med., 16, pp. 619-624; Tian, X., Li, C., Huang, A., Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody (2020) Emerg. Microb. Infect., 9, pp. 382-385; Zhang, L., Liu, Y., Potential interventions for novel coronavirus in China: a systematic review (2020) J. Med. Virol.; Graham, R.L., Donaldson, E.F., Baric, R.S., A decade after SARS: strategies for controlling emerging coronaviruses (2013) Nat. Rev. Microbiol., 11, pp. 836-848","Meng, L.; Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science CenterChina; email: mengliesu@xjtu.edu.cn",,Xi'an Jiaotong University,20951779,,,,English,J. Pharmaceut.Analy.,Review,Article in Press,Open Access,Scopus,2-s2.0-85081948804,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Guo T., Fan Y., Chen M., Wu X., Zhang L., He T., Wang H., Wan J., Wang X., Lu Z.",57215964880;57215962580;55733193700;57215968138;56609843300;57215970532;57215966412;57215968556;57211283467;7404768616;,Cardiovascular Implications of Fatal Outcomes of Patients with Coronavirus Disease 2019 (COVID-19),2020,JAMA Cardiology,,,,,,,2,10.1001/jamacardio.2020.1017,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082441674&doi=10.1001%2fjamacardio.2020.1017&partnerID=40&md5=ecf383bce1a074349897e10662b5a4c6,"Department of Cardiology, Zhongnan Hospital of Wuhan University, 169 East Lake Rd, Wuhan, Hubei, 430071, China; Department of Urology, Zhongnan Hospital of Wuhan University, 169 East Lake Rd, Wuhan, Hubei, 430071, China","Guo, T., Department of Cardiology, Zhongnan Hospital of Wuhan University, 169 East Lake Rd, Wuhan, Hubei, 430071, China; Fan, Y., Department of Cardiology, Zhongnan Hospital of Wuhan University, 169 East Lake Rd, Wuhan, Hubei, 430071, China; Chen, M., Department of Cardiology, Zhongnan Hospital of Wuhan University, 169 East Lake Rd, Wuhan, Hubei, 430071, China; Wu, X., Department of Cardiology, Zhongnan Hospital of Wuhan University, 169 East Lake Rd, Wuhan, Hubei, 430071, China; Zhang, L., Department of Cardiology, Zhongnan Hospital of Wuhan University, 169 East Lake Rd, Wuhan, Hubei, 430071, China; He, T., Department of Cardiology, Zhongnan Hospital of Wuhan University, 169 East Lake Rd, Wuhan, Hubei, 430071, China; Wang, H., Department of Cardiology, Zhongnan Hospital of Wuhan University, 169 East Lake Rd, Wuhan, Hubei, 430071, China; Wan, J., Department of Cardiology, Zhongnan Hospital of Wuhan University, 169 East Lake Rd, Wuhan, Hubei, 430071, China; Wang, X., Department of Urology, Zhongnan Hospital of Wuhan University, 169 East Lake Rd, Wuhan, Hubei, 430071, China; Lu, Z., Department of Cardiology, Zhongnan Hospital of Wuhan University, 169 East Lake Rd, Wuhan, Hubei, 430071, China","Importance: Increasing numbers of confirmed cases and mortality rates of coronavirus disease 2019 (COVID-19) are occurring in several countries and continents. Information regarding the impact of cardiovascular complication on fatal outcome is scarce. Objective: To evaluate the association of underlying cardiovascular disease (CVD) and myocardial injury with fatal outcomes in patients with COVID-19. Design, Setting, and Participants: This retrospective single-center case series analyzed patients with COVID-19 at the Seventh Hospital of Wuhan City, China, from January 23, 2020, to February 23, 2020. Analysis began February 25, 2020. Main Outcomes and Measures: Demographic data, laboratory findings, comorbidities, and treatments were collected and analyzed in patients with and without elevation of troponin T (TnT) levels. Result: Among 187 patients with confirmed COVID-19, 144 patients (77%) were discharged and 43 patients (23%) died. The mean (SD) age was 58.50 (14.66) years. Overall, 66 (35.3%) had underlying CVD including hypertension, coronary heart disease, and cardiomyopathy, and 52 (27.8%) exhibited myocardial injury as indicated by elevated TnT levels. The mortality during hospitalization was 7.62% (8 of 105) for patients without underlying CVD and normal TnT levels, 13.33% (4 of 30) for those with underlying CVD and normal TnT levels, 37.50% (6 of 16) for those without underlying CVD but elevated TnT levels, and 69.44% (25 of 36) for those with underlying CVD and elevated TnTs. Patients with underlying CVD were more likely to exhibit elevation of TnT levels compared with the patients without CVD (36 [54.5%] vs 16 [13.2%]). Plasma TnT levels demonstrated a high and significantly positive linear correlation with plasma high-sensitivity C-reactive protein levels (β = 0.530, P <.001) and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels (β = 0.613, P <.001). Plasma TnT and NT-proBNP levels during hospitalization (median [interquartile range (IQR)], 0.307 [0.094-0.600]; 1902.00 [728.35-8100.00]) and impending death (median [IQR], 0.141 [0.058-0.860]; 5375 [1179.50-25695.25]) increased significantly compared with admission values (median [IQR], 0.0355 [0.015-0.102]; 796.90 [401.93-1742.25]) in patients who died (P =.001; P <.001), while no significant dynamic changes of TnT (median [IQR], 0.010 [0.007-0.019]; 0.013 [0.007-0.022]; 0.011 [0.007-0.016]) and NT-proBNP (median [IQR], 352.20 [174.70-636.70]; 433.80 [155.80-1272.60]; 145.40 [63.4-526.50]) was observed in survivors (P =.96; P =.16). During hospitalization, patients with elevated TnT levels had more frequent malignant arrhythmias, and the use of glucocorticoid therapy (37 [71.2%] vs 69 [51.1%]) and mechanical ventilation (41 [59.6%] vs 14 [10.4%]) were higher compared with patients with normal TnT levels. The mortality rates of patients with and without use of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers was 36.8% (7 of 19) and 25.6% (43 of 168). Conclusions and Relevance: Myocardial injury is significantly associated with fatal outcome of COVID-19, while the prognosis of patients with underlying CVD but without myocardial injury is relatively favorable. Myocardial injury is associated with cardiac dysfunction and arrhythmias. Inflammation may be a potential mechanism for myocardial injury. Aggressive treatment may be considered for patients at high risk of myocardial injury.. © 2020 Cambridge University Press. All rights reserved.",,,"Lu, H., Stratton, C.W., Tang, Y.W., Outbreak of pneumonia of unknown etiology in Wuhan, China: The mystery and the miracle (2020) J Med Virol, 92 (4), pp. 401-402. , http://dx.doi.org/10.1002/jmv.25678, doi: 31950516; Hui, D.S., Azhar E, I., Madani, T.A., The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health: The latest 2019 novel coronavirus outbreak in Wuhan, China (2020) Int J Infect Dis, 91, pp. 264-266. , http://dx.doi.org/10.1016/j.ijid.2020.01.009, doi: PMID 31953166; Paules, C.I., Marston, H.D., Fauci, A.S., Coronavirus infections: More than just the common cold (2020) JAMA, , http://jamanetwork.com/article.aspx?doi=10.1001/jama.2020.0757, Published online January 23, doi: PMID 31971553; (2019) Report of Clustering Pneumonia of Unknown Etiology in Wuhan City, , http://wjw.wuhan.gov.cn/front/web/showDetail/2019123108989, Wuhan Municipal Health Commission, Published December 31, Accessed January 31, 2020; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395 (10223), pp. 497-506. , http://dx.doi.org/10.1016/S0140-6736(20)30183-5, doi: PMID 31986264; Wang, D., Hu, B., Hu, C., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) JAMA, , http://jamanetwork.com/article.aspx?doi=10.1001/jama.2020.1585, Published February 7, doi: PMID 32031570; (2020) Clinical Management of Severe Acute Respiratory Infection When Novel Coronavirus (NCoV) Infection Is Suspected, , https://www.who.int/publications-detail/clinical-management-of-severe-acute-respiratory-infection-when-novel-coronavirus-(ncov)-infection-is-suspected, Published March 13, Accessed January 28, 2020; World Medical Association Declaration of Helsinki: Ethical principles for medical research involving human subjects (2013) JAMA, 310 (20), pp. 2191-2194. , http://jamanetwork.com/article.aspx?doi=10.1001/jama.2013.281053; Ranieri, V.M., Rubenfeld, G.D., Thompson, B.T., Acute respiratory distress syndrome: The Berlin Definition (2012) JAMA, 307 (23), pp. 2526-2533. , PMID 22797452; Wu, Z., McGoogan, J.M., Characteristics of and important lessons from the coronavirus disease 2019 (covid-19) outbreak in China: Summary of a report of 72314 cases from the Chinese Center for Disease Control and Prevention (2020) JAMA, , http://jamanetwork.com/article.aspx?doi=10.1001/jama.2020.2648, Published online February 24, doi: PMID 32091533; Oudit, G.Y., Kassiri, Z., Jiang, C., SARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS (2009) Eur J Clin Invest, 39 (7), pp. 618-625. , http://dx.doi.org/10.1111/j.1365-2362.2009.02153.x, doi: PMID 19453650; Zhu, N., Zhang, D., Wang, W., A Novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382 (8), pp. 727-733. , http://dx.doi.org/10.1056/NEJMoa2001017, doi: PMID 31978945; Xu, X., Chen, P., Wang, J., Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission (2020) Sci China Life Sci, 63 (3), pp. 457-460. , http://dx.doi.org/10.1007/s11427-020-1637-5, doi: PMID 32009228; Henry, C., Zaizafoun, M., Stock, E., Ghamande, S., Arroliga, A.C., White, H.D., Impact of angiotensin-converting enzyme inhibitors and statins on viral pneumonia (2018) Proc (Bayl Univ Med Cent), 31 (4), pp. 419-423. , http://dx.doi.org/10.1080/08998280.2018.1499293, doi: PMID 30948970; Kuba, K., Imai, Y., Rao, S., A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury (2005) Nat Med, 11 (8), pp. 875-879. , http://dx.doi.org/10.1038/nm1267, doi: PMID 16007097","Wang, X.; Department of Urology, Zhongnan Hospital of Wuhan University, 169 East Lake Rd, China; email: wangxinghuan@whu.edu.cn",,American Medical Association,23806583,,,32219356,English,JAMA Cardiol.,Article,Article in Press,Open Access,Scopus,2-s2.0-85082441674,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Weston S., Frieman M.B.",56118663600;9240056500;,"COVID-19: Knowns, unknowns, and questions",2020,mSphere,5,2, e00203,,,,,10.1128/MSPHERE.00203-20,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081995335&doi=10.1128%2fMSPHERE.00203-20&partnerID=40&md5=e80d9abc25580cb2e63e113a059454a6,"Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, United States","Weston, S., Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, United States; Frieman, M.B., Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, United States",The recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from the Hubei province in China in late 2019 demonstrates the epidemic potential of coronaviruses. The rapid spread of this virus across the world in only 2 months highlights the transmissibility of this family of viruses and the significant morbidity and mortality that they can cause. We highlight the current state of knowledge of coronavirus biology while answering questions concerning the current outbreak of SARS-CoV-2. © 2020 Weston and Frieman.,Coronavirus; COVID-19; SARS; SARS-CoV-2,"COVID-19; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; China; Coronavirus infection; human; pandemic; risk factor; virus pneumonia; Betacoronavirus; China; Coronavirus Infections; Humans; Pandemics; Pneumonia, Viral; Risk Factors","de Wit, E., van Doremalen, N., Falzarano, D., Munster, V.J., SARS and MERS: recent insights into emerging coronaviruses (2016) Nat Rev Microbiol, 14, pp. 523-534. , https://doi.org/10.1038/nrmicro.2016.81; Gralinski, L.E., Menachery, V.D., Return of the coronavirus: 2019-nCoV (2020) Viruses, 12, p. 135. , https://doi.org/10.3390/v12020135; Zhou, P., Yang, X-L., Wang, X-G., Hu, B., Zhang, L., Zhang, W., Si, H-R., Shi, Z-L., Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin (2020), https://www.biorxiv.org/content/10.1101/2020.01.22.914952v2; 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Alharbi, N.K., Qasim, I., Almasoud, A., Aljami, H.A., Alenazi, M.W., Alhafufi, A., Aldibasi, O.S., Balkhy, H.H., Humoral immunogenicity and efficacy of a single dose of ChAdOx1 MERS vaccine candidate in dromedary camels (2019) Sci Rep, 9, p. 16292. , https://doi.org/10.1038/s41598-019-52730-4; The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China (2020) Zhonghua Liu Xing Bing Xue Za Zhi, 41, pp. 145-151. , https://doi.org/10.3760/cma.j.issn.0254-6450.2020.02.003; Imai, N., Dorigatti, I., Cori, A., Donnelly, C., Riley, S., Ferguson, N.M., (2020) Report 2: estimating the potential total number of novel coronavirus cases in Wuhan City, China, , Imperial College London, London, United Kingdom; Roberts, A., Paddock, C., Vogel, L., Butler, E., Zaki, S., Subbarao, K., Aged BALB/c mice as a model for increased severity of severe acute respiratory syndrome in elderly humans (2005) J Virol, 79, pp. 5833-5838. , https://doi.org/10.1128/JVI.79.9.5833-5838.2005; 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Kulcsar, K.A., Coleman, C.M., Beck, S.E., Frieman, M.B., Comorbid diabetes results in immune dysregulation and enhanced disease severity following MERS-CoV infection (2019) JCI Insight, 4. , https://doi.org/10.1172/jci.insight.131774; Roberts, A., Deming, D., Paddock, C.D., Cheng, A., Yount, B., Vogel, L., Herman, B.D., Subbarao, K., A mouse-adapted SARS-coronavirus causes disease and mortality in BALB/c mice (2007) PLoS Pathog, 3. , https://doi.org/10.1371/journal.ppat.0030005; Sheahan, T.P., Sims, A.C., Graham, R.L., Menachery, V.D., Gralinski, L.E., Case, J.B., Leist, S.R., Baric, R.S., Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses (2017) Sci Transl Med, 9. , https://doi.org/10.1126/scitranslmed.aal3653; Brown, A.J., Won, J.J., Graham, R.L., Dinnon, K.H., Sims, A.C., Feng, J.Y., Cihlar, T., Sheahan, T.P., Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase (2019) Antiviral Res, 169, p. 104541. , https://doi.org/10.1016/j.antiviral.2019.104541; Wang, M., Cao, R., Zhang, L., Yang, X., Liu, J., Xu, M., Shi, Z., Xiao, G., Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro (2020) Cell Res, 30, pp. 269-271. , https://doi.org/10.1038/s41422-020-0282-0; Gao, J., Tian, Z., Yang, X., Breakthrough: chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies (2020) Biosci Trends, , https://doi.org/10.5582/bst.2020.01047; Schindewolf, C., Menachery, V.D., Middle East respiratory syndrome vaccine candidates: cautious optimism (2019) Viruses, 11, p. 74. , https://doi.org/10.3390/v11010074; Menachery, V.D., Yount, B.L., Sims, A.C., Debbink, K., Agnihothram, S.S., Gralinski, L.E., Graham, R.L., Baric, R.S., SARS-like WIV1-CoV poised for human emergence (2016) Proc Natl Acad Sci U S A, 113, pp. 3048-3053. , https://doi.org/10.1073/pnas.1517719113; Menachery, V.D., Yount, B.L., Debbink, K., Agnihothram, S., Gralinski, L.E., Plante, J.A., Graham, R.L., Baric, R.S., A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence (2015) Nat Med, 21, pp. 1508-1513. , https://doi.org/10.1038/nm.3985; Ge, X.Y., Li, J.L., Yang, X.L., Chmura, A.A., Zhu, G., Epstein, J.H., Mazet, J.K., Shi, Z.L., Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor (2013) Nature, 503, pp. 535-538. , https://doi.org/10.1038/nature12711","Frieman, M.B.; Department of Microbiology and Immunology, University of Maryland School of MedicineUnited States; email: mfrieman@som.umaryland.edu",,American Society for Microbiology,23795042,,,32188753,English,mSphere,Article,Final,Open Access,Scopus,2-s2.0-85081995335,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Baron S.A., Devaux C., Colson P., Raoult D., Rolain J.-M.",57190620393;57216036980;7102090499;36040059800;6701695724;,Teicoplanin: an alternative drug for the treatment of COVID-19?,2020,International Journal of Antimicrobial Agents,,,105944,,,,,10.1016/j.ijantimicag.2020.105944,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082525961&doi=10.1016%2fj.ijantimicag.2020.105944&partnerID=40&md5=a5fc3023a21803a3371729e448595953,"Aix-Marseille Université, IRD, APHM, MEPHI, Faculté de Médecine et de Pharmacie, 19–21 boulevard Jean Moulin, 13385 Marseille Cedex 05, France; Aix-Marseille Université, IRD, APHM, VITROME, Faculté de Médecine et de Pharmacie, 19–21 boulevard Jean Moulin, 13385 Marseille Cedex 05, France; IHU–Méditerranée Infection, 19–21 boulevard Jean Moulin, 13385 Marseille Cedex 05, France","Baron, S.A., Aix-Marseille Université, IRD, APHM, MEPHI, Faculté de Médecine et de Pharmacie, 19–21 boulevard Jean Moulin, 13385 Marseille Cedex 05, France; Devaux, C., Aix-Marseille Université, IRD, APHM, VITROME, Faculté de Médecine et de Pharmacie, 19–21 boulevard Jean Moulin, 13385 Marseille Cedex 05, France; Colson, P., Aix-Marseille Université, IRD, APHM, MEPHI, Faculté de Médecine et de Pharmacie, 19–21 boulevard Jean Moulin, 13385 Marseille Cedex 05, France; Raoult, D., Aix-Marseille Université, IRD, APHM, MEPHI, Faculté de Médecine et de Pharmacie, 19–21 boulevard Jean Moulin, 13385 Marseille Cedex 05, France, IHU–Méditerranée Infection, 19–21 boulevard Jean Moulin, 13385 Marseille Cedex 05, France; Rolain, J.-M., Aix-Marseille Université, IRD, APHM, MEPHI, Faculté de Médecine et de Pharmacie, 19–21 boulevard Jean Moulin, 13385 Marseille Cedex 05, France, IHU–Méditerranée Infection, 19–21 boulevard Jean Moulin, 13385 Marseille Cedex 05, France","In December 2019, a novel coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged from China causing pneumonia outbreaks, first in the Wuhan region of China and then spread worldwide because of its probable high transmission efficiency. Owing to the lack of efficient and specific treatments and the need to contain the epidemic, drug repurposing appears to be the best tool to find a therapeutic solution. Chloroquine, remdesivir, lopinavir, ribavirin and ritonavir have shown efficacy to inhibit coronavirus in vitro. Teicoplanin, an antibiotic used to treat staphylococcal infections, previously showed efficacy to inhibit the first stage of the Middle East respiratory syndrome coronavirus (MERS-CoV) viral life cycle in human cells. This activity is conserved against SARS-Cov-2, thus placing teicoplanin as a potential treatment for patients with this virus. © 2020 Elsevier B.V. and International Society of Chemotherapy",COVID-19; Drug repurposing; SARS-CoV-2; Teicoplanin,,"Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382, pp. 727-733; Lai, C.-C., Shih, T.-P., Ko, W.-C., Tang, H.-J., Hsueh, P.-R., Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): the epidemic and the challenges (2020) Int J Antimicrob Agents; Devaux, C.A., Rolain, J.-M., Colson, P., Raoult, D., New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19? (2020) Int J Antimicrob Agents, , Forthcoming; Wang, M., Cao, R., Zhang, L., Yang, X., Liu, J., Xu, M., Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro (2020) Cell Res, 30, pp. 269-271; Colson, P., Rolain, J.-M., Raoult, D., Chloroquine for the 2019 novel coronavirus SARS-CoV-2 (2020) Int J Antimicrob Agents; Ko, W.-C., Rolain, J.-M., Lee, N.-Y., Chen, P.-L., Huang, C.-T., Lee, P.-I., Remdesivir for SARS-CoV-2 pneumonia (2020) Int J Antimicrob Agents, , Forthcoming; Zhang, J., Ma, X., Yu, F., Liu, J., Zou, F., Pan, T., Teicoplanin potently blocks the cell entry of 2019-nCoV (2020) bioRxiv; Zhou, N., Pan, T., Zhang, J., Li, Q., Zhang, X., Bai, C., Glycopeptide antibiotics potently inhibit cathepsin L in the late endosome/lysosome and block the entry of Ebola virus, Middle East respiratory syndrome coronavirus (MERS-CoV), and severe acute respiratory syndrome coronavirus (SARS-CoV) (2016) J Biol Chem, 291, pp. 9218-9232; Colson, P., Raoult, D., Fighting viruses with antibiotics: an overlooked path (2016) Int J Antimicrob Agents, 48, pp. 349-352; Pan, T., Zhou, N., Zhang, H., Use of teicoplanin anti-Middle East respiratory syndrome coronavirus (2015), https://patentscope.wipo.int/search/en/detail.jsf;jsessionid=50F31F08D2ACF24BD9AFE0C123BF028B.wapp2nC?docId=WO2016201692&tab=PCTBIBLIO, WIPO PatentScope Publication number: WO/2016/201692 [accessed 14 March 2020]","Rolain, J.-M.; Aix-Marseille Université, IRD, APHM, MEPHI, IHU–Méditerranée Infection, Faculté de Médecine et de Pharmacie, 19–21 boulevard Jean Moulin, 13385 Marseille Cedex 05, France; email: jean-marc.rolain@univ-amu.fr",,Elsevier B.V.,9248579,,IAAGE,32179150,English,Int. J. Antimicrob. Agents,Editorial,Article in Press,Open Access,Scopus,2-s2.0-85082525961,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Li Y.-C., Bai W.-Z., Hashikawa T.",56661515000;16038653300;7005824098;,The neuroinvasive potential of SARS-CoV2 may be at least partially responsible for the respiratory failure of COVID-19 patients,2020,Journal of Medical Virology,,,,,,,1,10.1002/jmv.25728,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081347109&doi=10.1002%2fjmv.25728&partnerID=40&md5=8f23b89e9304db7f79ece60391a9c23c,"Department of Histology and Embryology, College of Basic Medical Sciences, Norman Bethune College of Medicine, Jilin University, Changchun, Jilin, China; Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Science, Beijing, China; Neural Architecture, Advanced Technology Development Group, RIKEN Brain Science Institute, Saitama, Japan","Li, Y.-C., Department of Histology and Embryology, College of Basic Medical Sciences, Norman Bethune College of Medicine, Jilin University, Changchun, Jilin, China; Bai, W.-Z., Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Science, Beijing, China; Hashikawa, T., Neural Architecture, Advanced Technology Development Group, RIKEN Brain Science Institute, Saitama, Japan","Following the severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), another highly pathogenic coronavirus named SARS-CoV-2 (previously known as 2019-nCoV) emerged in December 2019 in Wuhan, China, and rapidly spreads around the world. This virus shares highly homological sequence with SARS-CoV, and causes acute, highly lethal pneumonia coronavirus disease 2019 (COVID-19) with clinical symptoms similar to those reported for SARS-CoV and MERS-CoV. The most characteristic symptom of patients with COVID-19 is respiratory distress, and most of the patients admitted to the intensive care could not breathe spontaneously. Additionally, some patients with COVID-19 also showed neurologic signs, such as headache, nausea, and vomiting. Increasing evidence shows that coronaviruses are not always confined to the respiratory tract and that they may also invade the central nervous system inducing neurological diseases. The infection of SARS-CoV has been reported in the brains from both patients and experimental animals, where the brainstem was heavily infected. Furthermore, some coronaviruses have been demonstrated able to spread via a synapse-connected route to the medullary cardiorespiratory center from the mechanoreceptors and chemoreceptors in the lung and lower respiratory airways. In light of the high similarity between SARS-CoV and SARS-CoV2, it is quite likely that the potential invasion of SARS-CoV2 is partially responsible for the acute respiratory failure of patients with COVID-19. Awareness of this will have important guiding significance for the prevention and treatment of the SARS-CoV-2-induced respiratory failure. © 2020 Wiley Periodicals, Inc.",cell susceptibility; coronavirus; dissemination; nervous system,,"Glass, W.G., Subbarao, K., Murphy, B., Murphy, P.M., Mechanisms of host defense following severe acute respiratory syndrome-coronavirus (SARS-CoV) pulmonary infection of mice (2004) J Immunol, 173, pp. 4030-4039; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506; Yu, F., Du, L., Ojcius, D.M., Pan, C., Jiang, S., Measures for diagnosing and treating infections by a novel coronavirus responsible for a pneumonia outbreak originating in Wuhan, China (2020) Microbes Infect, , https://doi.org/10.1016/j.micinf.2020.01.003; Song, Z., Xu, Y., Bao, L., From SARS to MERS, thrusting coronaviruses into the spotlight (2019) Viruses, 11, p. 59. , https://doi.org/10.3390/v11010059; Lu, R., Zhao, X., Li, J., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet, 395, pp. 565-574; Wan, Y., Shang, J., Graham, R., Baric, R.S., Li, F., Receptor recognition by novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS (2020) J Virol, , https://doi.org/10.1128/JVI.00127-20; Yuan, Y., Cao, D., Zhang, Y., Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains (2017) Nat Commun, 8; Hulswit, R.J., de Haan, C.A., Bosch, B.J., Coronavirus spike protein and tropism changes (2016) Adv Virus Res, 96, pp. 29-57; Li, Y.C., Bai, W.Z., Hirano, N., Hayashida, T., Hashikawa, T., Coronavirus infection of rat dorsal root ganglia: ultrastructural characterization of viral replication, transfer, and the early response of satellite cells (2012) Virus Res, 163, pp. 628-635; Wang, D., Hu, B., Hu, C., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) JAMA, , https://doi.org/10.1001/jama.2020.1585; Khan, S., Ali, A., Siddique, R., Nabi, G., Novel coronavirus is putting the whole world on alert (2020) J Hosp Infect, , https://doi.org/10.1016/j.jhin.2020.01.019; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395 (10223), pp. 507-513; Li, K., Wohlford-Lenane, C., Perlman, S., Middle East respiratory syndrome coronavirus causes multiple organ damage and lethal disease in mice transgenic for human dipeptidyl peptidase 4 (2016) J Infect Dis, 213, pp. 712-722; Talbot, P.J., Ekandé, S., Cashman, N.R., Mounir, S., Stewart, J.N., Neurotropism of human coronavirus 229E (1993) Adv Exp Med Biol, 342, pp. 339-346; Dubé, M., Le Coupanec, A., Wong, A.H.M., Rini, J.M., Desforges, M., Talbot, P.J., Axonal transport enables neuron-to-neuron propagation of human coronavirus OC43 (2018) J Virol, 92. , https://doi.org/10.1128/JVI.00404-18; Zhou, X., Huang, F., Xu, L., Hepatitis E virus infects neurons and brains (2017) J Infect Dis, 215 (8), pp. 1197-1206; Li, Y.C., Bai, W.Z., Hirano, N., Neurotropic virus tracing suggests a membranous-coating-mediated mechanism for transsynaptic communication (2013) J Comp Neurol, 521, pp. 203-212; Mengeling, W.L., Boothe, A.D., Ritchie, A.E., Characteristics of a coronavirus (strain 67N) of pigs (1972) Am J Vet Res, 33 (2), pp. 297-308; Andries, K., Pensaert, M.B., Immunofluorescence studies on the pathogenesis of hemagglutinating encephalomyelitis virus infection in pigs after oronasal inoculation (1980) Am J Vet Res, 41 (9), pp. 1372-1378; To, K.F., Lo, A.W., Exploring the pathogenesis of severe acute respiratory syndrome (SARS): the tissue distribution of the coronavirus (SARS-CoV) and its putative receptor, angiotensin-converting enzyme 2 (ACE2) (2004) J Pathol, 203, pp. 740-743; Tang, J.W., To, K.F., Lo, A.W., Sung, J.J., Ng, H.K., Chan, P.K., Quantitative temporal-spatial distribution of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) in post-mortem tissues (2007) J Med Virol, 79, pp. 1245-1253; Kam, Y.W., Okumura, Y., Kido, H., Ng, L.F., Bruzzone, R., Altmeyer, R., Cleavage of the SARS coronavirus spike glycoprotein by airway proteases enhances virus entry into human bronchial epithelial cells in vitro (2009) PLoS One, 4 (11); Donoghue, M., Hsieh, F., Baronas, E., A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9 (2000) Circ Res, 87 (5), pp. E1-E9; Harmer, D., Gilbert, M., Borman, R., Clark, K.L., Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme (2002) FEBS Lett, 532, pp. 107-110; Hamming, I., Timens, W., Bulthuis, M.L., Lely, A.T., Navis, G., van Goor, H., Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis (2004) J Pathol, 203 (2), pp. 631-637; Mattern, T., Scholz, W., Feller, A.C., Flad, H.D., Ulmer, A.J., Expression of CD26 (dipeptidyl peptidase IV) on resting and activated human T-lymphocytes (1991) Scand J Immunol, 33, pp. 737-748; Boonacker, E., Van Noorden, C.J., The multifunctional or moonlighting protein CD26/DPPIV (2003) Eur J Cell Biol, 82, pp. 53-73; Chan, P.K., To, K.F., Lo, A.W., Persistent infection of SARS coronavirus in colonic cells in vitro (2004) J Med Virol, 74, pp. 1-7; Ding, Y., Wang, H., Shen, H., The clinical pathology of severe acute respiratory syndrome (SARS): a report from China (2003) J Pathol, 200, pp. 282-289; Bernstein, H.G., Dobrowolny, H., Keilhoff, G., Steiner, J., Dipeptidyl peptidase IV, which probably plays important roles in alzheimer disease (AD) pathology, is upregulated in AD brain neurons and associates with amyloid plaques (2018) Neurochem Int, 114, pp. 55-57; Ding, Y., He, L., Zhang, Q., Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways (2004) J Pathol, 203, pp. 622-630; Gu, J., Gong, E., Zhang, B., Multiple organ infection and the pathogenesis of SARS (2005) J Exp Med, 202 (3), pp. 415-424; Xu, J., Zhong, S., Liu, J., Detection of severe acute respiratory syndrome coronavirus in the brain: potential role of the chemokine mig in pathogenesis (2005) Clin Infect Dis, 41, pp. 1089-1096; Netland, J., Meyerholz, D.K., Moore, S., Cassell, M., Perlman, S., Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2 (2008) J Virol, 82, pp. 7264-7275; McCray, P.B., Jr., Pewe, L., Wohlford-Lenane, C., Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus (2007) J Virol, 81, pp. 813-821; Matsuda, K., Park, C.H., Sunden, Y., The vagus nerve is one route of transneural invasion for intranasally inoculated influenza a virus in mice (2004) Vet Pathol, 41, pp. 101-107; Chasey, D., Alexander, D.J., Morphogenesis of avian infectious bronchitis virus in primary chick kidney cells (1976) Arch Virol, 52, pp. 101-111; González, J.M., Gomez-Puertas, P., Cavanagh, D., Gorbalenya, A.E., Enjuanes, L., A comparative sequence analysis to revise the current taxonomy of the family coronaviridae (2003) Arch Virol, 148, pp. 2207-2235; Li, Z., He, W., Lan, Y., The evidence of porcine hemagglutinating encephalomyelitis virus induced nonsuppurative encephalitis as the cause of death in piglets (2016) Peer J, 4; Kalia, M., Mesulam, M.M., Brain stem projections of sensory and motor components of the vagus complex in the cat: II. Laryngeal, tracheobronchial, pulmonary, cardiac, and gastrointestinal branches (1980) J Comp Neurol, 193, pp. 467-508; Hadziefendic, S., Haxhiu, M.A., CNS innervation of vagal preganglionic neurons controlling peripheral airways: a transneuronal labeling study using pseudorabies virus (1999) J Auton Nerv Syst, 76, pp. 135-145; Raux, H., Flamand, A., Blondel, D., Interaction of the rabies virus P protein with the LC8 dynein light chain (2000) J Virol, 74, pp. 10212-10216; Rothe, C., Schunk, M., Sothmann, P., Transmission of 2019-nCoV infection from an asymptomatic contact in Germany (2020) N Engl J Med, , https://doi.org/10.1056/NEJMc2001468","Li, Y.-C.; Department of Histology and Embryology, College of Basic Medical Sciences, Norman Bethune College of Medicine, Jilin UniversityChina; email: liyanchao@jlu.edu.cn",,John Wiley and Sons Inc.,1466615,,JMVID,32104915,English,J. Med. Virol.,Review,Article in Press,Open Access,Scopus,2-s2.0-85081347109,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Grifoni A., Sidney J., Zhang Y., Scheuermann R.H., Peters B., Sette A.",55425663600;7004798698;56230384400;7006976175;8561294600;35418504700;,A Sequence Homology and Bioinformatic Approach Can Predict Candidate Targets for Immune Responses to SARS-CoV-2,2020,Cell Host and Microbe,,,,,,,,10.1016/j.chom.2020.03.002,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082485355&doi=10.1016%2fj.chom.2020.03.002&partnerID=40&md5=7d197cd8c84d89004277be212dd51a3c,"Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA 92037, United States; J. Craig Venter Institute, La Jolla, CA 92037, United States; Department of Pathology, University of California, San Diego, San Diego, CA 92093, United States; Department of Medicine, University of California, San Diego, San Diego, CA 92093, United States","Grifoni, A., Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA 92037, United States; Sidney, J., Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA 92037, United States; Zhang, Y., J. Craig Venter Institute, La Jolla, CA 92037, United States; Scheuermann, R.H., Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA 92037, United States, J. Craig Venter Institute, La Jolla, CA 92037, United States, Department of Pathology, University of California, San Diego, San Diego, CA 92093, United States; Peters, B., Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA 92037, United States, Department of Medicine, University of California, San Diego, San Diego, CA 92093, United States; Sette, A., Division of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, CA 92037, United States, Department of Medicine, University of California, San Diego, San Diego, CA 92093, United States","Effective countermeasures against the recent emergence and rapid expansion of the 2019 novel coronavirus (SARS-CoV-2) require the development of data and tools to understand and monitor its spread and immune responses to it. However, little information is available about the targets of immune responses to SARS-CoV-2. We used the Immune Epitope Database and Analysis Resource (IEDB) to catalog available data related to other coronaviruses. This includes SARS-CoV, which has high sequence similarity to SARS-CoV-2 and is the best-characterized coronavirus in terms of epitope responses. We identified multiple specific regions in SARS-CoV-2 that have high homology to the SARS-CoV virus. Parallel bioinformatic predictions identified a priori potential B and T cell epitopes for SARS-CoV-2. The independent identification of the same regions using two approaches reflects the high probability that these regions are promising targets for immune recognition of SARS-CoV-2. These predictions can facilitate effective vaccine design against this virus of high priority. © 2020Grifoni et al. identify potential targets for immune responses to the 2019 novel coronavirus (SARS-CoV-2) by sequence homology with closely related SARS-CoV and by a priori epitope prediction using bioinformatics approaches. This analysis provides essential information for understanding human immune responses to this virus and for evaluating diagnostic and vaccine candidates. © 2020",B cell epitope; coronavirus; COVID-19; infectious disease; SARS-CoV; SARS-CoV-2; sequence conservation; T cell epitope,,"Carrasco Pro, S., Sidney, J., Paul, S., Lindestam Arlehamn, C., Weiskopf, D., Peters, B., Sette, A., Automatic Generation of Validated Specific Epitope Sets (2015) J. Immunol. Res., 2015, p. 763461; Cheung, Y.K., Cheng, S.C., Sin, F.W., Chan, K.T., Xie, Y., Induction of T-cell response by a DNA vaccine encoding a novel HLA-A∗0201 severe acute respiratory syndrome coronavirus epitope (2007) Vaccine, 25, pp. 6070-6077; Cheung, Y.K., Cheng, S.C., Sin, F.W., Chan, K.T., Xie, Y., Investigation of immunogenic T-cell epitopes in SARS virus nucleocapsid protein and their role in the prevention and treatment of SARS infection (2008) Hong Kong Med. 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Immunol., 21, pp. 63-71; Zhang, Q., Wang, P., Kim, Y., Haste-Andersen, P., Beaver, J., Bourne, P.E., Bui, H.H., Greenbaum, J., Immune epitope database analysis resource (IEDB-AR) (2008) Nucleic Acids Res., 36, p. W513-8","Sette, A.; Division of Vaccine Discovery, La Jolla Institute for ImmunologyUnited States; email: alex@lji.org",,Cell Press,19313128,,,32183941,English,Cell Host and Microbe,Article,Article in Press,Open Access,Scopus,2-s2.0-85082485355,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Lung J., Lin Y.-S., Yang Y.-H., Chou Y.-L., Shu L.-H., Cheng Y.-C., Liu H.T., Wu C.-Y.",6602733212;57209831439;57204898179;57215810940;57215811604;57194583410;57215819276;55890284600;,The potential chemical structure of anti-SARS-CoV-2 RNA-dependent RNA polymerase,2020,Journal of Medical Virology,,,,,,,,10.1002/jmv.25761,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081973139&doi=10.1002%2fjmv.25761&partnerID=40&md5=f24517404479a3cde0e08f7e16a4ab73,"Department of Research and Development, Chiayi Chang Gung Memorial Hospital, Chiayi Branch, Putzu, Taiwan; Department of Pharmacy, Chiayi Chang Gung Memorial Hospital, Chiayi Branch, Putzu, Taiwan; Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Chiayi Branch, Putzu, Taiwan; Health Information and Epidemiology Laboratory of Chang Gung Memorial Hospital, Chiayi Branch, Putzu, Taiwan; School of Chinese medicine, Chang Gung University, Taoyuan, Taiwan; Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan","Lung, J., Department of Research and Development, Chiayi Chang Gung Memorial Hospital, Chiayi Branch, Putzu, Taiwan; Lin, Y.-S., Department of Pharmacy, Chiayi Chang Gung Memorial Hospital, Chiayi Branch, Putzu, Taiwan; Yang, Y.-H., Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Chiayi Branch, Putzu, Taiwan, Health Information and Epidemiology Laboratory of Chang Gung Memorial Hospital, Chiayi Branch, Putzu, Taiwan, School of Chinese medicine, Chang Gung University, Taoyuan, Taiwan; Chou, Y.-L., Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan; Shu, L.-H., Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Chiayi Branch, Putzu, Taiwan; Cheng, Y.-C., Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Chiayi Branch, Putzu, Taiwan; Liu, H.T., Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Chiayi Branch, Putzu, Taiwan; Wu, C.-Y., Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Chiayi Branch, Putzu, Taiwan, School of Chinese medicine, Chang Gung University, Taoyuan, Taiwan","An outbreak of coronavirus disease 2019 (COVID-19) occurred in Wuhan and it has rapidly spread to almost all parts of the world. For coronaviruses, RNA-dependent RNA polymerase (RdRp) is an important protease that catalyzes the replication of RNA from RNA template and is an attractive therapeutic target. In this study, we screened these chemical structures from traditional Chinese medicinal compounds proven to show antiviral activity in severe acute respiratory syndrome coronavirus (SARS-CoV) and the similar chemical structures through a molecular docking study to target RdRp of SARS-CoV-2, SARS-CoV, and Middle East respiratory syndrome coronavirus (MERS-CoV). We found that theaflavin has a lower idock score in the catalytic pocket of RdRp in SARS-CoV-2 (−9.11 kcal/mol), SARS-CoV (−8.03 kcal/mol), and MERS-CoV (−8.26 kcal/mol) from idock. To confirm the result, we discovered that theaflavin has lower binding energy of −8.8 kcal/mol when it docks in the catalytic pocket of SARS-CoV-2 RdRp by using the Blind Docking server. Regarding contact modes, hydrophobic interactions contribute significantly in binding and additional hydrogen bonds were found between theaflavin and RdRp. Moreover, one π-cation interaction was formed between theaflavin and Arg553 from the Blind Docking server. Our results suggest that theaflavin could be a potential SARS-CoV-2 RdRp inhibitor for further study. © 2020 Wiley Periodicals, Inc.",RNA-dependent RNA polymerase; SARS-CoV-2; theaflavin; traditional Chinese medicinal compounds,,"Dey, S.K., Rahman, M.M., Siddiqi, U.R., Howlader, A., Analyzing the epidemiological outbreak of COVID-19: a visual exploratory data analysis (EDA) approach (2020) J Med Virol, , https://doi.org/10.1002/jmv.25743; Liu, W., Morse, J.S., Lalonde, T., Xu, S., Learning from the past: possible urgent prevention and treatment options for severe acute respiratory infections caused by 2019-nCoV (2020) ChemBioChem, 21, pp. 730-738; Zhang, L., Liu, Y., Potential interventions for novel coronavirus in China: a systematic review (2020) J Med Virol, , https://doi.org/10.1002/jmv.25707; Gordon, C.J., Tchesnokov, E.P., Feng, J.Y., Porter, D.P., Gotte, M., The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus (2020) J Biol Chem, , https://doi.org/10.1074/jbc.AC120.013056, pii; Tchesnokov, E.P., Feng, J.Y., Porter, D.P., Gotte, M., Mechanism of inhibition of Ebola virus RNA-dependent RNA polymerase by remdesivir (2019) Viruses, 11 (4); Holshue, M.L., DeBolt, C., Lindquist, S., First case of 2019 novel coronavirus in the United States (2020) N Engl J Med, 382, pp. 929-936; Eswar, N., Eramian, D., Webb, B., Shen, M.Y., Sali, A., Protein structure modeling with MODELLER (2008) Methods Mol Biol, 426, pp. 145-159; Pettersen, E.F., Goddard, T.D., Huang, C.C., UCSF Chimera—a visualization system for exploratory research and analysis (2004) J Comput Chem, 25 (13), pp. 1605-1612; Waterhouse, A., Bertoni, M., Bienert, S., SWISS-MODEL: homology modelling of protein structures and complexes (2018) Nucleic Acids Res, 46 (W1), pp. W296-W303; Zhang, M.M., Liu, X.M., He, L., Effect of integrated traditional Chinese and Western medicine on SARS: a review of clinical evidence (2004) World J Gastroenterol, 10 (23), pp. 3500-3505; Cinatl, J., Morgenstern, B., Bauer, G., Chandra, P., Rabenau, H., Doerr, H.W., Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus (2003) Lancet, 361 (9374), pp. 2045-2046; Ryu, Y.B., Jeong, H.J., Kim, J.H., Biflavonoids from Torreya nucifera displaying SARS-CoV 3CL(pro) inhibition (2010) Bioorg Med Chem, 18 (22), pp. 7940-7947; Park, J.Y., Kim, J.H., Kim, Y.M., Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases (2012) Bioorg Med Chem, 20 (19), pp. 5928-5935; Yi, L., Li, Z., Yuan, K., Small molecules blocking the entry of severe acute respiratory syndrome coronavirus into host cells (2004) J Virol, 78 (20), pp. 11334-11339; Yang, Z.F., Bai, L.P., Huang, W., Comparison of in vitro antiviral activity of tea polyphenols against influenza A and B viruses and structure-activity relationship analysis (2014) Fitoterapia, 93, pp. 47-53; Chowdhury, P., Sahuc, M.E., Rouillé, Y., Theaflavins, polyphenols of black tea, inhibit entry of hepatitis C virus in cell culture (2018) PLoS One, 13 (11); Chen, C.N., Lin, C.P.C., Huang, K.K., Inhibition of SARS-CoV 3C-like protease activity by theaflavin-3,3′-digallate (TF3) (2005) Evid Based Complement Alternat Med, 2 (2), pp. 209-215","Wu, C.-Y.; Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Chiayi BranchTaiwan; email: smbepigwu77@gmail.com",,John Wiley and Sons Inc.,1466615,,JMVID,32167173,English,J. Med. Virol.,Article,Article in Press,Open Access,Scopus,2-s2.0-85081973139,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Gurwitz D.,7006459919;,Angiotensin receptor blockers as tentative SARS-CoV-2 therapeutics,2020,Drug Development Research,,,,,,,1,10.1002/ddr.21656,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080917087&doi=10.1002%2fddr.21656&partnerID=40&md5=36491c923e3824fa96fe35453c4a858b,"Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel","Gurwitz, D., Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel","At the time of writing this commentary (February 2020), the coronavirus COVID-19 epidemic has already resulted in more fatalities compared with the SARS and MERS coronavirus epidemics combined. Therapeutics that may assist to contain its rapid spread and reduce its high mortality rates are urgently needed. Developing vaccines against the SARS-CoV-2 virus may take many months. Moreover, vaccines based on viral-encoded peptides may not be effective against future coronavirus epidemics, as virus mutations could make them futile. Indeed, new Influenza virus strains emerge every year, requiring new immunizations. A tentative suggestion based on existing therapeutics, which would likely be resistant to new coronavirus mutations, is to use available angiotensin receptor 1 (AT1R) blockers, such as losartan, as therapeutics for reducing the aggressiveness and mortality from SARS-CoV-2 virus infections. This idea is based on observations that the angiotensin-converting enzyme 2 (ACE2) very likely serves as the binding site for SARS-CoV-2, the strain implicated in the current COVID-19 epidemic, similarly to strain SARS-CoV implicated in the 2002–2003 SARS epidemic. This commentary elaborates on the idea of considering AT1R blockers as tentative treatment for SARS-CoV-2 infections, and proposes a research direction based on datamining of clinical patient records for assessing its feasibility. © 2020 Wiley Periodicals, Inc.",angiotensin-converting enzyme 2 (ACE2); AT1R blockers; COVID-19 epidemic; losartan; SARS-CoV-2,,"Beigel, J.H., Nam, H.H., Adams, P.L., Krafft, A., Ince, W.L., El-Kamary, S.S., Sims, A.C., Advances in respiratory virus therapeutics—A meeting report from the 6th isirv Antiviral Group conference (2019) Antiviral Research, 167, pp. 45-67. , https://doi.org/10.1016/j.antiviral.2019.04.006; Belongia, E.A., Skowronski, D.M., McLean, H.Q., Chambers, C., Sundaram, M.E., De Serres, G., Repeated annual influenza vaccination and vaccine effectiveness: Review of evidence (2017) Expert Review of Vaccines, 16 (7), pp. 1-14. , https://doi.org/10.1080/14760584.2017.1334554; Chen, Y., Guo, Y., Pan, Y., Zhao, Z.J., Structure analysis of the receptor binding of 2019-nCoV (2020) Biochemical and Biophysical Research Communications, , https://doi.org/10.1016/j.bbrc.2020.02.071, [Epub ahead of print]; Cheng, Z.J., Shan, J., 2019 Novel coronavirus: Where we are and what we know (2020) Infection, , https://doi.org/10.1007/s15010-020-01401-y, [Epub ahead of print]; Deppe, S., Böger, R.H., Weiss, J., Benndorf, R.A., Telmisartan: A review of its pharmacodynamic and pharmacokinetic properties (2010) Expert Opinion on Drug Metabolism & Toxicology, 6 (7), pp. 863-871. , https://doi.org/10.1517/17425255.2010.494597; de Wit, E., van Doremalen, N., Falzarano, D., Munster, V.J., SARS and MERS: Recent insights into emerging coronaviruses (2016) Nature Reviews. Microbiology, 14 (8), pp. 523-534. , https://doi.org/10.1038/nrmicro.2016.81; Dimitrov, D.S., The secret life of ACE2 as a receptor for the SARS virus (2003) Cell, 115 (6), pp. 652-653; Gao, J., Tian, Z., Yang, X., Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies (2020) Bioscience Trends, , https://doi.org/10.5582/bst.2020.01047, [Epub ahead of print]; Furuhashi, M., Moniwa, N., Mita, T., Fuseya, T., Ishimura, S., Ohno, K., Miura, T., Urinary angiotensin-converting enzyme 2 in hypertensive patients may be increased by olmesartan, an angiotensin II receptor blocker (2015) American Journal of Hypertension, 28 (1), pp. 15-21. , https://doi.org/10.1093/ajh/hpu086; Ge, X.Y., Li, J.L., Yang, X.L., Chmura, A.A., Zhu, G., Epstein, J.H., Shi, Z.L., Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor (2013) Nature, 503 (7477), pp. 535-538. , https://doi.org/10.1038/nature12711; Huentelman, M.J., Zubcevic, J., Hernández Prada, J.A., Xiao, X., Dimitrov, D.S., Raizada, M.K., Ostrov, D.A., Structure-based discovery of a novel angiotensin-converting enzyme 2 inhibitor (2004) Hypertension, 44 (6), pp. 903-906; Imai, Y., Kuba, K., Rao, S., Huan, Y., Guo, F., Guan, B., Penninger, J.M., Angiotensin-converting enzyme 2 protects from severe acute lung failure (2005) Nature, 436 (7047), pp. 112-116; Ishiyama, Y., Gallagher, P.E., Averill, D.B., Tallant, E.A., Brosnihan, K.B., Ferrario, C.M., Upregulation of angiotensin-converting enzyme 2 after myocardial infarction by blockade of angiotensin II receptors (2004) Hypertension, 43 (5), pp. 970-976; Klimas, J., Olvedy, M., Ochodnicka-Mackovicova, K., Kruzliak, P., Cacanyiova, S., Kristek, F., Ochodnicky, P., Perinatally administered losartan augments renal ACE2 expression but not cardiac or renal Mas receptor in spontaneously hypertensive rats (2015) Journal of Cellular and Molecular Medicine, 19 (8), pp. 1965-1974. , https://doi.org/10.1111/jcmm.12573; Kuba, K., Imai, Y., Rao, S., Gao, H., Guo, F., Guan, B., Penninger, J.M., A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury (2005) Nature Medicine, 11 (8), pp. 875-879; Li, G., Clercq, E., Therapeutic options for the 2019 novel coronavirus (2019-nCoV) (2020) Nat Rev Drug Discov, , https://doi.org/10.1038/d41573-020-00016-0, De, [Epub ahead of print]; Li, W., Moore, M.J., Vasilieva, N., Sui, J., Wong, S.K., Berne, M.A., Farzan, M., Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus (2003) Nature, 426 (6965), pp. 450-454; Lu, R., Zhao, X., Li, J., Niu, P., Yang, B., Wu, H., Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding (2020) Lancet, , https://doi.org/10.1016/S0140-6736(20)30251-8, [Epub ahead of print]; Luo, H., Tang, Q.L., Shang, Y.X., Liang, S.B., Yang, M., Robinson, N., Liu, J.P., Can Chinese medicine be used for prevention of Corona virus disease 2019 (COVID-19)? A review of historical classics, research evidence and current prevention programs (2020) Chinese Journal of Integrative Medicine, , https://doi.org/10.1007/s11655-020-3192-6, [Epub ahead of print]; Mahase, E., Coronavirus covid-19 has killed more people than SARS and MERS combined, despite lower case fatality rate (2020) BMJ, , https://doi.org/10.1136/bmj.m641; McIntyre, M., Caffe, S.E., Michalak, R.A., Reid, J.L., Losartan, an orally active angiotensin (AT1) receptor antagonist: A review of its efficacy and safety in essential hypertension (1997) Pharmacology & Therapeutics, 74 (2), pp. 181-194; Michel, N., Allespach, I., Venzke, S., Fackfmicheller, O.T., Keppler, O.T., The Nef protein of human immunodeficiency virus establishes superinfection immunity by a dual strategy to downregulate cell-surface CCR5 and CD4 (2005) Current Biology, 15 (8), pp. 714-723; Patel, A., Jernigan, D.B., Initial public health response and Interim clinical guidance for the 2019 Novel Coronavirus Outbreak—United States, December 31, 2019-February 4, 2020 (2020) MMWR Morbidity and Mortality Weekly Report, 69 (5), pp. 140-146. , https://doi.org/10.15585/mmwr.mm6905e1; Phadke, M., Saunik, S., Rapid response: Use of angiotensin receptor blockers such as Telmisartan, Losartsan in nCoV Wuhan Corona Virus infections—Novel mode of treatment. Response to the emerging novel coronavirus outbreak (2020) BMJ 2020, 368. , https://doi.org/10.1136/bmj.m406; Prabakaran, P., Xiao, X., Dimitrov, D.S., A model of the ACE2 structure and function as a SARS-CoV receptor (2004) Biochemical and Biophysical Research Communications, 314 (1), pp. 235-241; Santos, R.A., Simoes e Silva, A.C., Maric, C., Silva, D.M., Machado, R.P., de Buhr, I., Walther, T., Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas (2003) Proceedings of the National Academy of Sciences of the United States of America, 100 (14), pp. 8258-8263; Smyth, L.J., Cañadas-Garre, M., Cappa, R.C., Maxwell, A.P., McKnight, A.J., Genetic associations between genes in the renin–angiotensin–aldosterone system and renal disease: A systematic review and meta-analysis (2019) BMJ Open, 9 (4). , https://doi.org/10.1136/bmjopen-2018-026777; Sun, M.L., Yang, J.M., Sun, Y.P., Su, G.H., Inhibitors of RAS might be a good choice for the therapy of COVID-19 pneumonia (2020) Zhonghua Jie He He Hu Xi Za Zhi, 43. , https://doi.org/10.3760/cma.j.issn.1001-0939.2020.0014, [Epub ahead of print]. Chinese; Tseng, C.T., Sbrana, E., Iwata-Yoshikawa, N., Newman, P.C., Garron, T., Atmar, R.L., Couch, R.B., Immunization with SARS coronavirus vaccines leads to pulmonary immunopathology on challenge with the SARS virus (2012) PLoS One, 7 (4). , https://doi.org/10.1371/journal.pone.0035421; Turner, A.J., Hiscox, J.A., Hooper, N.M., ACE2: from vasopeptidase to SARS virus receptor (2004) Trends in Pharmacological Sciences, 25 (6), pp. 291-294; Wan, Y., Shang, J., Graham, R., Baric, R.S., Li, F., Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS (2020) J Virol, , https://doi.org/10.1128/JVI.00127-20, [Epub ahead of print]; (2019) Coronavirus disease (COVID-19) outbreak, , https://www.who.int/emergencies/diseases/novel-coronavirus-2019; Yu, C.M., Wong, R.S., Wu, E.B., Kong, S.L., Wong, J., Yip, G.W., Sung, J.J., Cardiovascular complications of severe acute respiratory syndrome (2006) Postgraduate Medical Journal, 82 (964), pp. 140-144; Zhang, L., Liu, Y., Potential Interventions for Novel Coronavirus in China: A systematic review (2020) Journal of Medical Virology, , https://doi.org/10.1002/jmv.25707, [Epub ahead of print]","Gurwitz, D.; Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel-Aviv UniversityIsrael; email: gurwitz@post.tau.ac.il",,Wiley-Liss Inc.,2724391,,DDRED,,English,Drug Dev. Res.,Note,Article in Press,Open Access,Scopus,2-s2.0-85080917087,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Uhart M., Vanstreels R.E.T., Gallo L., Cook R.A., Karesh W.B.",6602721366;36081416900;55768383600;7403131061;55990995700;,"Serological survey for select infectious agents in wild magellanic penguins (Spheniscus magellanicus) in Argentina, 1994–2008",2020,Journal of Wildlife Diseases,56,1,,66,81,,,10.7589/2019-01-022,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077761322&doi=10.7589%2f2019-01-022&partnerID=40&md5=3ef744f78c4776eebdaf247d139d41e5,"One Health Institute, School of Veterinary Medicine, University of California, Davis, 1089 Veterinary Medicine Drive, VM3B, Davis, CA 95616, United States; Wildlife Conservation Society, 2300 Southern Boulevard, Bronx, NY 10460, United States; Instituto de Pesquisa e Reabilitação de Animais Marinhos, Rodovia BR-262 km 0, Jardim América, Cariacica, Espírito Santo 29140-130, Brazil; Instituto de Biología de Organismos Marinos, Consejo Nacional de Investigaciones Científicas y Técnicas, Boulevard Brown 2915, Puerto Madryn, Chubut U9120ACD, Argentina; Science Based Support Consulting, 28 Sassinoro Boulevard, Cortlandt Manor, NY 10567, United States; EcoHealth Alliance, 460 W 34th Street, 17th Floor, New York, NY 10001, United States","Uhart, M., One Health Institute, School of Veterinary Medicine, University of California, Davis, 1089 Veterinary Medicine Drive, VM3B, Davis, CA 95616, United States, Wildlife Conservation Society, 2300 Southern Boulevard, Bronx, NY 10460, United States; Vanstreels, R.E.T., One Health Institute, School of Veterinary Medicine, University of California, Davis, 1089 Veterinary Medicine Drive, VM3B, Davis, CA 95616, United States, Instituto de Pesquisa e Reabilitação de Animais Marinhos, Rodovia BR-262 km 0, Jardim América, Cariacica, Espírito Santo 29140-130, Brazil; Gallo, L., Instituto de Biología de Organismos Marinos, Consejo Nacional de Investigaciones Científicas y Técnicas, Boulevard Brown 2915, Puerto Madryn, Chubut U9120ACD, Argentina; Cook, R.A., Wildlife Conservation Society, 2300 Southern Boulevard, Bronx, NY 10460, United States, Science Based Support Consulting, 28 Sassinoro Boulevard, Cortlandt Manor, NY 10567, United States; Karesh, W.B., Wildlife Conservation Society, 2300 Southern Boulevard, Bronx, NY 10460, United States, EcoHealth Alliance, 460 W 34th Street, 17th Floor, New York, NY 10001, United States","Despite being the most numerous penguin species in South America, exposure of the Magellanic Penguin (Spheniscus magellanicus) to pathogens has not yet been thoroughly assessed. We collected serum from 1,058 Magellanic Penguins at 10 breeding colonies along the entire latitudinal range of this species in Argentina. The work spanned 10 breeding seasons over 15 yr (1994–2008). Sera were tested for antibodies to select infectious agents. Antibodies reacting against 16 pathogens were detected (seroprevalence): Aspergillus sp. (15.1%), Chlamydia psittaci (6.5%), Salmonella Pullorum (3.1%), Salmonella Typhimurium (81.3%), Aviadenovirus sp. (18.1%), Duck atadenovirus A (23.6%), Anatid herpesvirus 1 (0.7%), Avian orthoreovirus (3.3%), Avian coronavirus M41 (43.5%), Avian coronavirus C46 (59.8%), Avian coronavirus A99 (37.4%), Avian coronavirus JMK (40.2%), Tremovirus A (0.3%), Avian avulavirus 1 (44.0%), Avian avulavirus 2 (43.8%), and Avian avulavirus 3 (46.6%). No antibodies were detected against nine infectious agents: Gallid alphaherpesvirus 1, Gallid alphaherpesvirus 2, Infectious bursal disease virus, Avastrovirus 2, West Nile virus, Eastern equine encephalitis virus, Venezuelan equine encephalitis virus, Western equine encephalitis virus, and Influenza A virus. While restricted by limitations inherent to serological methods, our results provide baseline knowledge for a key species in the South Atlantic Ocean. This information is valuable for adaptive conservation management in a time of increasing environmental stressors affecting the Patagonian Sea, one of the world’s richest pelagic seabird communities. © Wildlife Disease Association 2020.",Adaptive management; Environmental stressors; Health; Penguin; Seabird; Serology; South America; Sphenisciformes,,"Adair, B.M., Todd, D., McFerran, J.B., McKillop, E.R., Comparative serological studies with egg drop syndrome virus (1986) Avian Pathol, 15, pp. 677-685; Alexander, D.J., Manvell, R.J., Collins, M.S., Brockman, S.J., Westbury, H.A., Morgan, I., Austin, F.J., Characterization of paramyxoviruses isolated from penguins in Antarctica and sub-Antarctica during 1976–1979 (1989) Arch Virol, 109, pp. 135-143; Alley, M.R., Suepaul, R.B., McKinlay, B., Young, M.J., Wang, J., Morgan, K.J., Hunter, S.A., Gartrell, B.D., Diph-theritic stomatitis in Yellow-eyed Penguins (Mega-dyptes antipodes) in New Zealand (2017) J Wildl Dis, 53, pp. 102-110; Andersen, A., Vanrompay, D., (2003) Avian Chlamydiosis (Psittacosis, Ornithosis), pp. 863-879. , Diseases of poultry. 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Wildl. Dis.,Article,Final,,Scopus,2-s2.0-85077761322,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Srinivasan S., Cui H., Gao Z., Liu M., Lu S., Mkandawire W., Narykov O., Sun M., Korkin D.",57210861269;56623784600;57216039683;57212144302;57216036087;57216041132;57210862273;57216038373;8779137600;,Structural genomics of SARS-COV-2 indicates evolutionary conserved functional regions of viral proteins,2020,Viruses,12,4,360,,,,,10.3390/v12040360,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082522988&doi=10.3390%2fv12040360&partnerID=40&md5=f058bfdb5cc1c04a9bdaec5ac46eb131,"Data Science Program, Worcester Polytechnic Institute, Worcester, MA 01609, United States; Bioinformatics and Computational Biology Program, Worcester Polytechnic Institute, Worcester, MA 01609, United States; Computer Science Department, Worcester Polytechnic Institute, Worcester, MA 01609, United States","Srinivasan, S., Data Science Program, Worcester Polytechnic Institute, Worcester, MA 01609, United States; Cui, H., Bioinformatics and Computational Biology Program, Worcester Polytechnic Institute, Worcester, MA 01609, United States; Gao, Z., Bioinformatics and Computational Biology Program, Worcester Polytechnic Institute, Worcester, MA 01609, United States; Liu, M., Bioinformatics and Computational Biology Program, Worcester Polytechnic Institute, Worcester, MA 01609, United States; Lu, S., Bioinformatics and Computational Biology Program, Worcester Polytechnic Institute, Worcester, MA 01609, United States; Mkandawire, W., Bioinformatics and Computational Biology Program, Worcester Polytechnic Institute, Worcester, MA 01609, United States; Narykov, O., Computer Science Department, Worcester Polytechnic Institute, Worcester, MA 01609, United States; Sun, M., Bioinformatics and Computational Biology Program, Worcester Polytechnic Institute, Worcester, MA 01609, United States; Korkin, D., Data Science Program, Worcester Polytechnic Institute, Worcester, MA 01609, United States, Bioinformatics and Computational Biology Program, Worcester Polytechnic Institute, Worcester, MA 01609, United States, Computer Science Department, Worcester Polytechnic Institute, Worcester, MA 01609, United States","During its first two and a half months, the recently emerged 2019 novel coronavirus, SARS-CoV-2, has already infected over one-hundred thousand people worldwide and has taken more than four thousand lives. However, the swiftly spreading virus also caused an unprecedentedly rapid response from the research community facing the unknown health challenge of potentially enormous proportions. Unfortunately, the experimental research to understand the molecular mechanisms behind the viral infection and to design a vaccine or antivirals is costly and takes months to develop. To expedite the advancement of our knowledge, we leveraged data about the related coronaviruses that is readily available in public databases and integrated these data into a single computational pipeline. As a result, we provide comprehensive structural genomics and interactomics roadmaps of SARS-CoV-2 and use this information to infer the possible functional differences and similarities with the related SARS coronavirus. 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Virol., 85, pp. 4122-4134; Hoffmann, M., Kleine-Weber, H., Krüger, N., Müller, M., Drosten, C., Pöhlmann, S., Müller, M.A., The novel coronavirus 2019 (2019-nCoV) uses the SARS-coronavirus receptor ACE2 and the cellular protease TMPRSS2 for entry into target cells (2020) bioRxiv; Kruse, R.L., Therapeutic strategies in an outbreak scenario to treat the novel coronavirus originating in Wuhan, China (2020) F1000 Res, 9, p. 72; Voitenko, O.S., Dhroso, A., Feldmann, A., Korkin, D., Kalinina, O.V., Patterns of amino acid conservation in human and animal immunodeficiency viruses (2016) Bioinformatics, 32, pp. i685-i692","Korkin, D.; Data Science Program, Worcester Polytechnic InstituteUnited States; email: korkin@korkinlab.org",,MDPI AG,19994915,,,32218151,English,Viruses,Article,Final,Open Access,Scopus,2-s2.0-85082522988,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Palacios Cruz M., Santos E., Velázquez Cervantes M.A., León Juárez M.",57215828733;57215830548;57206196245;54881935700;,"COVID-19, a worldwide public health emergency [COVID-19, una emergencia de salud pública mundial]",2020,Revista Clinica Espanola,,,,,,,,10.1016/j.rce.2020.03.001,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082011122&doi=10.1016%2fj.rce.2020.03.001&partnerID=40&md5=b66c125bd7ec3d850415e785dc64b4e3,"Facultad de Medicina, Universidad Veracruzana, Veracruz, Mexico; Department of Neurosurgery, University of Heidelberg, Heidelberg, Germany; Departamento de Inmunobioquímica, Laboratorio de Virología Perinatal, Instituto Nacional de Perinatología, Ciudad de México, Mexico","Palacios Cruz, M., Facultad de Medicina, Universidad Veracruzana, Veracruz, Mexico; Santos, E., Department of Neurosurgery, University of Heidelberg, Heidelberg, Germany; Velázquez Cervantes, M.A., Departamento de Inmunobioquímica, Laboratorio de Virología Perinatal, Instituto Nacional de Perinatología, Ciudad de México, Mexico; León Juárez, M., Departamento de Inmunobioquímica, Laboratorio de Virología Perinatal, Instituto Nacional de Perinatología, Ciudad de México, Mexico","A new coronavirus outbreak emerged on the 31st of December 2019 in Wuhan, China, causing commotion among the medical community and the rest of the world. This new species of coronavirus has been termed 2019-nCoV and has caused a considerable number of cases of infection and deaths in China and, to a growing degree, beyond China, becoming a worldwide public health emergency. 2019-nCoV has high homology to other pathogenic coronaviruses, such as those originating from bat-related zoonosis (SARS-CoV), which caused approximately 646 deaths in China at the start of the decade. The mortality rate for 2019-nCoV is not as high (approximately 2-3%), but its rapid propagation has resulted in the activation of protocols to stop its spread. This pathogen has the potential to become a pandemic. It is therefore vital to follow the personal care recommendations issued by the World Health Organisation. © 2020 Elsevier España, S.L.U. and Sociedad Española de Medicina Interna (SEMI)",Basic reproduction number; Clinical condition; Coronavirus; Diagnosis; Prevention; Transmission,,"Team, E.E., https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2020.25.3.2001231, Note from the editors: novel coronavirus (2019-nCoV). Eurosurveillance [consultado 31 Ene 2020]. Disponible en:; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet., 395, pp. 497-506; https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200213-sitrep-24-covid-19.pdf?sfvrsn=9a7406a4_4, OMS. Situation Report-24 [consultado 13 Feb 2020]. Disponible en:; Mahase, E., China coronavirus: WHO declares international emergency as death toll exceeds 200 (2020) BMJ., 368, p. m408; Paules, C.I., Marston, H.D., Fauci, A.S., Coronavirus infections-more than just the common cold (2020) JAMA., 323, pp. 707-708; De Wilde, A.H., Snijder, E.J., Kikkert, M., van Hemert, M.J., Host factors in coronavirus replication (2018) Curr Top Microbiol Immunol., 419, pp. 1-42; https://www.who.int/health-topics/coronavirus, OMS. Coronavirus. 2020 [consultado 2 Feb 2020]. Disponible en:; Masters, P.S., The molecular biology of coronaviruses (2006) Adv Virus Res., 66, pp. 193-292; Fung, T.S., Liu, D.X., Human coronavirus: host-pathogen interaction (2019) Annu Rev Microbiol., 73, pp. 529-557; Chen, Y., Liu, Q., Guo, D., Emerging coronaviruses: Genome structure, replication, and pathogenesis (2020) J Med Virol., 92, pp. 418-423; Liu, D.X., Inglis, S.C., Association of the infectious bronchitis virus 3 c protein with the virion envelope (1991) Virology., 185, pp. 911-917; Song, Z., Xu, Y., Bao, L., Zhang, L., Yu, P., Qu, Y., From SARS to MERS, thrusting coronaviruses into the spotlight (2019) Viruses., 11, p. 59; Cui, J., Li, F., Shi, Z.L., Origin and evolution of pathogenic coronaviruses (2019) Nat Rev Microbiol., 17, pp. 181-192; Wu, A., Peng, Y., Huang, B., Ding, X., Wang, X., Niu, P., Commentary genome composition and divergence of the novel coronavirus (2019-nCoV) originating in China (2020) Cell Host Microbe., pp. 1-4; Zhou, P., Yang, X.-L., Wang, X.-G., Hu, B., Zhang, L., Zhang, W., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature.; De Wit, E., van Doremalen, N., Falzarano, D., Munster, V.J., SARS and MERS: Recent insights into emerging coronaviruses (2016) Nat Rev Microbiol., 14, pp. 523-524; Callaway, E., Cyranoski, D., https://www.nature.com/magazine-assets/d41586-020-00166-6/17601640, New China virus: Five questions scientists are asking. Nature [consultado 2 Feb 2020]. Disponible en:; https://www.imperial.ac.uk/mrc-global-infectious-disease-analysis/news–wuhan-coronavirus/, News /2019-nCoV, Faculty of Medicine, Imperial College London [consultado 3 Feb 2020]. Disponible en:; Bogoch, I.I., Watts, A., Thomas-Bachli, A., Huber, C., Kraemer, M.U., Khan, K., Pneumonia of unknown etiology in Wuhan, China: Potential for international spread via commercial air travel (2020) J Travel Med.; Wu, J.T., Leung, K., Leung, G.M., Nowcasting and forecasting the Wuhan 2019-nCoV outbreak (2020) Lancet., 395, pp. 689-697; Zhao, S., Lin, Q., Ran, J., Musa, S.S., Yang, G., Wang, W., Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: A data-driven analysis in the early phase of the outbreak (2020) Int J Infect Dis., 92, pp. 214-217; Perlman, S., Another decade another coronavirus (2020) N Engl J Med., 382, pp. 760-762; Hui, D.S., Azhar, E.I., Kim, Y.J., Memish, Z.A., Oh, M.D., Zumla, A., Middle East respiratory syndrome coronavirus: risk factors and determinants of primary, household, and nosocomial transmission (2018) Lancet Infect Dis., 18, pp. e217-e227; Widagdo, W., Na Ayudhya, S.S., Hundie, G.B., Haagmans, B.L., Host determinants of MERS-CoV transmission and pathogenesis (2019) Viruses., 11, p. E280; https://www.who.int/emergencies/diseases/novel-coronavirus-2019/advice-for-public/myth-busters, OMS. Myth busters [consultado 7 Feb 2020]. Disponible en:; Chen, Z.M., Fu, J.F., Shu, Q., New coronavirus: new challenges for pediatricians (2020) World J Pediatr.; Zhou, P., Yang, X.L., Wang, X.-G., Hu, B., Zhang, L., Zhang, W., Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin (2020) bioRxiv.; Biscayart, C., Angeleri, P., Lloveras, S., Chaves, T., Schlagenhauf, P., Rodríguez-Morales, A.J., The next big threat to global health? 2019 novel coronavirus (2019-nCoV): What advice can we give to travellers? Interim recommendations January 2020, from the Latin-American society for Travel Medicine (SLAMVI) (2020) Travel Med Infect Dis., 33, p. 101567; Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet., 395, pp. 507-513; https://www.who.int/publications-detail/global-surveillance-for-human-infection-with-novel-coronavirus-.(2019-ncov), OMS. Global Surveillance for human infection with novel coronavirus (2019-nCoV) [consultado 3 Feb 2020]. Disponible en:; Corman, V.M., Landt, O., Kaiser, M., Molenkamp, R., Meijer, A., Chu, D.K., Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR (2020) Euro Surveill., 25, p. 2000045; Reusken, C.B.E.M., Broberg, E.K., Haagmans, B., Meijer, A., Corman, V.M., Papa, A., Laboratory readiness and response for novel coronavirus (2019-nCoV) in expert laboratories in 30 EU/EEA countries, January 2020 (2020) Euro Surveill., 25; https://www.who.int/publications-detail/laboratory-testing-for-2019-novel-coronavirus-in-suspected-human-cases-20200117, OMS. Laboratory testing for 2019 novel coronavirus (2019-nCoV) in suspected human cases [consultado 3 Feb 2020]. Disponible en:; https://www.who.int/ith/2020/0901_outbreak_of_Pneumonia_caused_by_a_new_coronavirus_in_C/en/, WHO advice for international travel and trade in relation to the outbreak of pneumonia caused by a new coronavirus in China [consultado 3 Feb 2020]. Disponible en:; Cheng, P.K.C., Wong, D.A., Tong, L.K.L., Ip, S.M., Lo, A.C.T., Lau, C.S., Viral shedding patterns of coronavirus in patients with probable severe acute respiratory syndrome (2004) Lancet., 363, pp. 1699-1700; Sheahan, T.P., Sims, A.C., Leist, S.R., Schäfer, A., Won, J., Brown, A.J., Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV (2020) Nat Commun., 11, p. 222; Graham, B.S., Mascola, J.R., Fauci, A.S., Novel vaccine technologies essential components of an adequate response to emerging viral diseases (2018) JAMA., 319, pp. 1431-1432","León Juárez, M.; Departamento de Inmunobioquímica, Laboratorio de Virología Perinatal, Instituto Nacional de PerinatologíaMexico; email: moisesleoninper@gmail.com",,Elsevier Doyma,142565,,RCESA,,English; Spanish,Rev. Clin. Esp.,Review,Article in Press,Open Access,Scopus,2-s2.0-85082011122,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Brnić D., Šimić I., Kovačević A., Krešić N.",55062397200;56779927100;57214878355;56780076500;,Viral gastroenteritis in pigs: Current knowledge and challenges [Virusni gastroenteritisi u svinja: Trenutne spoznaje i izazovi],2020,Veterinarska Stanica,51,1,,53,66,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079420972&partnerID=40&md5=09d374d4ca613294533aeb6bba4f10c1,"Croatian Veterinary Institute, Zagreb, Croatia","Brnić, D., Croatian Veterinary Institute, Zagreb, Croatia; Šimić, I., Croatian Veterinary Institute, Zagreb, Croatia; Kovačević, A., Croatian Veterinary Institute, Zagreb, Croatia; Krešić, N., Croatian Veterinary Institute, Zagreb, Croatia","Viral gastroenteritis in pigs is a continuous challenge for pig breeders, from the aspects of health management and the implementation of adequate biosecurity measures. The most important pathogens in its aetiology are coronaviruses and rotaviruses, having features such as excretion in high concentrations, low infective dose, extreme environmental stability and high contagiousness. Coronaviruses are the causative agents of important epizootics with high mortalities in nursing piglets (up to 100%), in particular the porcine epidemic diarrhoea virus (PEDV), which recently caused substantial losses for pig breeders in Croatia and worldwide. Apart from PEDV, notable coronaviruses in pigs are transmissible gastroenteritis virus (TGEV), porcine deltacoronavirus (PDCoV) and the recently described swine acute diarrhoea syndrome-coronavirus (SADS-CoV). Rotaviruses are also significant pathogens causing diarrhoea in young pigs, even though they are ubiquitous, with Rotavirus A (RVA) being the most important species among five rotavirus species known to circulate in pigs. Rotaviruses are known to possess a zoonotic potential which is also speculated for porcine deltacoronavirus, nevertheless coronaviruses of pigs have not yet been detected in humans. The example of SADS-CoV transmission from bats to pigs emphasizes the need for surveillance of wild animals known as a source of diseases that present a veterinary and public health threat. The pathogenesis, clinical appearance, autopsy and pathohistological findings are similar for all viral gastroenteritis in pigs. In case of an outbreak of watery and yellowish diarrhoea of high morbidity and mortality, especially in nursing piglets, the suspicion of viral aetiology is warranted. Therefore, early diagnosis is key for the implementation of adequate measures to prevent the disease from spreading and causing substantial losses. The therapy is only supportive and vaccines are not available on this market, therefore the control of these viral infections is based on good health management and the implementation of strict hygiene and sanitary measures, as well as internal and external biosecurity measures. © 2020 Croatian Veterinary Institute. All rights reserved.",Biosecurity measures; Coronaviridae; Gastroenteritis; Pig; Rotavirus,,"Akimkin, V., Beer, M., Blome, S., Hanke, D., Höper, D., Jenckel, M., Pohlmann, A., New Chimeric Porcine Coronavirus in Swine Feces, Germany, 2012 (2016) Emerg. Infect. Dis., 22, pp. 1314-1315; Alonso, C., Goede, D.P., Morrison, R.B., Davies, P.R., Rovira, A., Marthaler, D.G., Torremorell, M., Evidence of infectivity of airborne porcine epidemic diarrhea virus and detection of airborne viral RNA at long distances from infected herds (2014) Vet. Res., 45, p. 73; Banyai, K., Kemenesi, G., Budinski, I., Foldes, F., Zana, B., Marton, S., Vargakugler, R., Jakab, F., Candidate new rotavirus species in Schreiber's bats, Serbia (2017) Infect. Genet. Evol., 48, pp. 19-26; Boniotti, M.B., Papetti, A., Lavazza, A., Alborali, G., Sozzi, E., Chiapponi, C., Faccini, S., Marthaler, D., Porcine Epidemic Diarrhea Virus and Discovery of a Recombinant Swine Enteric Coronavirus, Italy (2016) Emerg. Infect. Dis., 22, pp. 83-87; Brnić, D., (2013) Dokazivanje i Filogenetska Analiza Astrovirusa U Potencijalnih Životinjskih Rezervoara U Republici Hrvatskoj, , Doktorski rad. Veterinarski fakultet Sveučilišta u Zagrebu; Brnić, D., Šimić, I., Lojkić, I., Krešić, N., Jungić, A., Balić, D., Lolić, M., Hengl, B., The emergence of porcine epidemic diarrhoea in Croatia: Molecular characterization and serology (2019) BMC Vet. Res., 15, p. 249; Carvajal, A., Argüello, H., Martínezlobo, F.J., Costillas, S., Miranda, R., De Nova, P.J.G., Rubio, P., Porcine epidemic diarrhoea: New insights into an old disease (2015) Porcine Health Manag., 1, p. 12; Chang, K.-O., Saif, J.L., Kim, Y., Reoviruses (Rotaviruses and Reoviruses) (2012) Diseases of Swine 10th Edition., pp. 621-634. , Eds J. Zimmerman, L. Karriker, A. Ramirez, K. Schwartz, G. Stevenson. Ames, Iowa, USA, Wiley-Blackwell; Crawford, S.E., Ramani, S., Tate, J.E., Parashar, U.D., Svensson, L., Hagbom, M., Franco, M.A., Estes, M.K., Rotavirus infection (2017) Nat. Rev. Dis. Primers, 3, p. 17083; Cvetnić, S., Transmisive gastroenteritis in swine (2005) Virus Animal Diseases, pp. 148-157. , Zagreb, Školska knjiga, (In Croatian); Dastjerdi, A., Carr, J., Ellis, R.J., Steinbach, F., Williamson, S., Porcine Epidemic Diarrhea Virus among Farmed Pigs, Ukraine (2015) Emerg. Infect. Dis., 21, pp. 2235-2237; Dee, S., Clement, T., Schelkopf, A., Nerem, J., Knudsen, D., Christopher-Hennings, J., Nelson, E., An evaluation of contaminated complete feed as a vehicle for porcine epidemic diarrhea virus infection of naïve pigs following consumption via natural feeding behavior: Proof of concept (2014) BMC Vet. Res., 10, p. 176; DIep, N.V., Norimine, J., Sueyoshi, M., Lan, N.T., Yamaguchi, R., Novel Porcine Epidemic Diarrhea Virus (PEDV) Variants with Large Deletions in the Spike (S) Gene Coexist with PEDV Strains Possessing an Intact S Gene in Domestic Pigs in Japan: A New Disease Situation (2017) PLOS One, 12, p. e0170126; Scientific Report on the collection and review of updated epidemiological data on porcine epidemic diarrhoea (2016) EFSA J., 14 (2), p. 4375. , EFSA; Estes, M.K., Greenberg, H.B., Rotaviruses (2013) Fields Virology, 6th Edition., pp. 1347-1401. , Eds. D. M. Knipe, P. M. Howley. Philadelphia, Wolters Kluwer, Health/Lippincott Williams & Wilkins; Goecke, N.B., Hjulsager, C.K., Kongsted, H., Boye, M., Rasmussen, S., Granberg, F., Fischer, T.K., Larsen, L.E., No evidence of enteric viral involvement in the new neonatal porcine diarrhoea syndrome in Danish pigs (2017) BMC Vet. Res., 13, p. 315; Grgić, I., Zrakić, M., Hadelan, L., Balance sheet of pork production and consumption in Croatia (2015) Meso, 17, pp. 160-165; Hižman, D., Eradication of PEDV infection from 7 farrow to wean farms in Croatia (2018) 10th European Symposium of Porcine Health Management, pp. VVD-024. , Barcelona, Spain; (2018) Coronaviridae Taxonomy, , https://talk.ictvonline.org/taxonomy/, ICTV; (2018) Rotavirus Taxonomy, , https://talk.ictvonline.org/taxonomy/, ICTV; Jemeršić, L., (2019) Afrička Svinjska Kuga, Hrvatska Akademija Znanosti i Umjetnosti, , Zavod za znanstvenoistraživački i umjetnički rad, Velika Gorica; Jung, K., Hu, H., Saif, L.J., Calves are susceptible to infection with the newly emerged porcine deltacoronavirus, but not with the swine enteric alphacoronavirus, porcine epidemic diarrhea virus (2017) Arch. Virol., 162, pp. 2357-2362; Jung, K., Saif, L.J., Porcine epidemic diarrhea virus infection: Etiology, epidemiology, pathogenesis and immunoprophylaxis (2015) Vet. J., 204, pp. 134-143; Kovačević, A., Krešić, N., Šimić, I., Škoko, I., Brnić, D., Molecular characterisation of Rotavirus A circulating among domestic animals in Croatia (2019) 8th International Congress ""Veterinary Science and Profession, 61. , Book of Abstracts, Zagreb; Lee, C., Porcine epidemic diarrhea virus: An emerging and re-emerging epizootic swine virus (2015) Virol. J., 12, p. 193; Leidenberger, S., Schröder, C., Zani, L., Auste, A., Pinette, M., Ambagala, A., Nikolin, V., Blome, S., Virulence of current German PEDV strains in suckling pigs and investigation of protective effects of maternally derived antibodies (2017) Sci. Rep., 7, p. 10825; Li, W., Hulswit, R.J.G., Kenney, S.P., Widjaja, I., Jung, K., Alhamo, M.A., Van DIeren, B., Bosch, B.-J., Broad receptor engagement of an emerging global coronavirus may potentiate its diverse cross-species transmissibility (2018) Proc. Natl. Acad. Sci. 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Beograd, 67, pp. 383-396; (2018) List of Accepted Genotypes by Rotavirus Classification Working Group, , https://rega.kuleuven.be/cev/viralmetagenomics/virusclassification/rcwg, RCWG, Pristupljeno 21. 11. 2019; Saif, J.L., Pensaert, M.B., Sestak, K., Yeo, S.G., Jung, K., Coronaviruses (2012) Diseases of Swine 10th Edition., pp. 501-524. , Eds J. J. ZIMMERMAN, L. A. KARRIKER, A. RAMIREZ, K. J. SCHWARTZ, G. W. STEVENSON. Ames, Iowa, USA, Wiley-Blackwell; Song, D., Moon, H., Kang, B., Porcine epidemic diarrhea: A review of current epidemiology and available vaccines (2015) Clin. Exp. Vaccine Res., 4, pp. 166-176; Stadler, J., Zoels, S., Fux, R., Hanke, D., Pohlmann, A., Blome, S., Weissenbock, H., Ladinig, A., Emergence of porcine epidemic diarrhea virus in southern Germany (2015) BMC Vet. Res., 11, p. 142; Stevenson, G.W., Hoang, H., Schwartz, K.J., Burrough, E.R., Sun, D., Madson, D., Cooper, V.L., Yoon, K.J., Emergence of porcine epidemic diarrhea virus in the United States: Clinical signs, lesions, and viral genomic sequences (2013) J. Vet. Diagn. Investig., 25, pp. 649-654; Su, Y., Hou, Y., Prarat, M., Zhang, Y., Wang, Q., New variants of porcine epidemic diarrhea virus with large deletions in the spike protein, identified in the United States, 2016-2017 (2018) Arch.Virol., 136, pp. 2485-2489; Šimić, I., (2019) Prisutnost Virusa U Populacijama Šišmiša U Hrvatskoj, , Doktorski rad. Prirodoslovnomatematički fakultet Sveučilišta u Zagrebu; Šimić, I., Kovačević, A., Krešić, N., Škoko, I., Jukić Guć, J., Krželj, V., Tešović, G., Brnić, D., Molekularne značajke i zoonotski potencijal rotavirusa (2019) Paediatr. Croat., 63, pp. 63-70; Vlasova, N.A., Amimo, O.J., Saif, J.L., Porcine Rotaviruses: Epidemiology, Immune Responses and Control Strategies (2017) Viruses, 9, p. 48; Wang, L., Byrum, B., Zhang, Y., New variant of porcine epidemic diarrhea virus, United States, 2014 (2014) Emerg. Infect. Dis., 20, pp. 917-919; Wang, Q., Vlasova, A.N., Kenney, S.P., Saif, L.J., Emerging and re-emerging coronaviruses in pigs (2019) Curr. Opin.Virol., 34, pp. 39-49; Woo, P.C.Y., Lau, S.K.P., Lam, C.S.F., Lau, C.C.Y., Tsang, A.K.L., Lau, J.H.N., Bai, R., Yuen, K.-Y., Discovery of seven novel Mammalian and avian coronaviruses in the genus deltacoronavirus supports bat coronaviruses as the gene source of alphacoronavirus and betacoronavirus and avian coronaviruses as the gene source of gammacoronavirus and deltacoronavirus (2012) J. Virol., 86, pp. 3995-4008; Zhou, P., Fan, H., Lan, T., Yang, X.-L., Shi, W.-F., Zhang, W., Zhu, Y., Ma, J.-Y., Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin (2018) Nature, 556, pp. 255-258","Brnić, D.; Croatian Veterinary InstituteCroatia; email: brnic@veinst.hr",,Croatian Veterinary Institute,3507149,,,,Croatian,Vet. Stn.,Review,Final,,Scopus,2-s2.0-85079420972,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Ai J.-W., Zhang Y., Zhang H.-C., Xu T., Zhang W.-H.",56414254400;57203815475;57197855152;57210990400;57210265229;,"Era of molecular diagnosis for pathogen identification of unexplained pneumonia, lessons to be learned",2020,Emerging Microbes and Infections,9,1,,597,600,,,10.1080/22221751.2020.1738905,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081894561&doi=10.1080%2f22221751.2020.1738905&partnerID=40&md5=8f98a7b29f335d9be5f91f31c1a06606,"Department of Infectious Diseases, National Clinical Research Center for Aging and Medicine, Huashan Hospital, State Key Laboratory of Genetic Engineering, School of Life Science, Key Laboratory of Medical Molecular Virology (MOE/MOH) and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China; Vision Medicals Co., Ltd, Guangzhou, China","Ai, J.-W., Department of Infectious Diseases, National Clinical Research Center for Aging and Medicine, Huashan Hospital, State Key Laboratory of Genetic Engineering, School of Life Science, Key Laboratory of Medical Molecular Virology (MOE/MOH) and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China; Zhang, Y., Department of Infectious Diseases, National Clinical Research Center for Aging and Medicine, Huashan Hospital, State Key Laboratory of Genetic Engineering, School of Life Science, Key Laboratory of Medical Molecular Virology (MOE/MOH) and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China; Zhang, H.-C., Department of Infectious Diseases, National Clinical Research Center for Aging and Medicine, Huashan Hospital, State Key Laboratory of Genetic Engineering, School of Life Science, Key Laboratory of Medical Molecular Virology (MOE/MOH) and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China; Xu, T., Vision Medicals Co., Ltd, Guangzhou, China; Zhang, W.-H., Department of Infectious Diseases, National Clinical Research Center for Aging and Medicine, Huashan Hospital, State Key Laboratory of Genetic Engineering, School of Life Science, Key Laboratory of Medical Molecular Virology (MOE/MOH) and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China","Unexplained pneumonia (UP) caused by a novel coronavirus SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) emerged in China in late December 2019 and has infected more than 9000 cases by 31 January 2020. Shanghai reported the first imported case of COVID-19 (Coronavirus Disease 2019) in 20 January 2020. A combinative approach of real-time RT–PCR, CRISPR-based assay and metagenomic next-generation sequencing (mNGS) were used to diagnose this unexplained pneumonia patient. Real-time RT–PCR and CRISPR-based assay both reported positive. This sample belonged to Betacoronavirus and shared a more than 99% nucleotide (nt) identity with the Wuhan SARS-CoV-2 isolates. We further compared pros and cons of common molecular diagnostics in UP. In this study, we illustrated the importance of combining molecular diagnostics to rule out common pathogens and performed mNGS to obtain unbiased potential pathogen result for the diagnosis of UP. © 2020, © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd.",COVID-19; diagnosis; molecular; SARS-CoV-2; Unexplained pneumonia,"CRISPR associated protein; nucleotide; COVID-19; severe acute respiratory syndrome coronavirus 2; adult; Betacoronavirus; case report; China; clinical article; clustered regularly interspaced short palindromic repeat; coronavirus disease 2019; Coronavirus infection; fatigue; female; fever; high throughput sequencing; human; infectious agent; Letter; metagenomics; middle aged; molecular diagnosis; multiplex polymerase chain reaction; nucleic acid amplification; pneumonia; priority journal; real time reverse transcription polymerase chain reaction; SARS coronavirus; SARS coronavirus 2; statistically significant result; throat culture; unexplained pneumonia; virus isolation; virus strain; Coronavirus infection; genetics; isolation and purification; molecular diagnosis; phylogeny; virus pneumonia; Betacoronavirus; Coronavirus Infections; Humans; Molecular Diagnostic Techniques; Phylogeny; Pneumonia, Viral","Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382 (8), pp. 727-733; Juan, D., https://www.chinadaily.com.cn/a/202001/01/WS5e0c6a49a310cf3e35581e30.html, Wuhan wet market closes amid pneumonia outbreak. China Daily, 2020 Jan 1. Available from; https://3g.dxy.cn/newh5/view/pneumonia?scene=2&clicktime=1579582238&enterid=1579582238&from=timeline&isappinstalled=0, [cited 2020 Jan 31]. Available from; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) The Lancet, 395 (10223), pp. 497-506; Chenna, R., Sugawara, H., Koike, T., Multiple sequence alignment with the clustal series of programs (2003) Nucleic Acids Res, 31 (13), pp. 3497-3500; Kumar, S., Stecher, G., Li, M., MEGA x: molecular evolutionary genetics analysis across computing platforms (2018) Mol Biol Evol, 35 (6), pp. 1547-1549; Zhang, N., Wang, L., Deng, X., Recent advances in the detection of respiratory virus infection in humans (2020) J Med Virol, 92 (4), pp. 408-417; Chan, J.F.-W., Yuan, S., Kok, K.-H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) The Lancet, 395 (10223), pp. 514-523; Zhou, P., Yang, X.L., Wang, X.G., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature, , https://doi.org/10.1038/s41586-020-2012-7, [Epub ahead of print]; Wu, F., Zhao, S., Yu, B., A new coronavirus associated with human respiratory disease in China (2020) Nature, , https://doi.org/10.1038/s41586-020-2008-3, [Epub ahead of print]; Chen, L., Liu, W., Zhang, Q., RNA based mNGS approach identifies a novel human coronavirus from two individual pneumonia cases in 2019 Wuhan outbreak (2020) Emerg Microbes Infect, 9 (1), pp. 313-319; Wilson, M.R., Sample, H.A., Zorn, K.C., Clinical metagenomic sequencing for diagnosis of meningitis and encephalitis (2019) N Engl J Med, 380 (24), pp. 2327-2340; Loeffelholz, M.J., Pong, D.L., Pyles, R.B., Comparison of the filmarray respiratory panel and prodesse real-time PCR assays for detection of respiratory pathogens (2011) J Clin Microbiol, 49 (12), pp. 4083-4088","Zhang, W.-H.; Department of Infectious Diseases, National Clinical Research Center for Aging and Medicine, Huashan Hospital, State Key Laboratory of Genetic Engineering, School of Life Science, Key Laboratory of Medical Molecular Virology (MOE/MOH) and Institutes of Biomedical Sciences, Shanghai Medical College, Fudan UniversityChina; email: wenhongzhang_hs@126.com",,Taylor and Francis Ltd.,22221751,,,32174267,English,Emerg. Microbes Infect.,Letter,Final,Open Access,Scopus,2-s2.0-85081894561,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Li X., Zai J., Zhao Q., Nie Q., Li Y., Foley B.T., Chaillon A.",57214468160;57191645661;57214898966;57215600722;57202366564;7007093414;23501286600;,"Evolutionary history, potential intermediate animal host, and cross-species analyses of SARS-CoV-2",2020,Journal of Medical Virology,,,,,,,5,10.1002/jmv.25731,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081322505&doi=10.1002%2fjmv.25731&partnerID=40&md5=bf6d6d047205b0528168a818ed0873d8,"Hubei Engineering Research Center of Viral Vector, Wuhan University of Bioengineering, Wuhan, China; Immunology Innovation Team, School of Medicine, Ningbo University, Ningbo, China; Precision Cancer Center Airport Center, Tianjin Cancer Hospital Airport Hospital, Tianjin, China; Department of Microbiology, Weifang Center for Disease Control and Prevention, Weifang, China; HIV Databases, Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM, United States; Department of Medicine, University of California San Diego, La Jolla, CA, United States","Li, X., Hubei Engineering Research Center of Viral Vector, Wuhan University of Bioengineering, Wuhan, China; Zai, J., Immunology Innovation Team, School of Medicine, Ningbo University, Ningbo, China; Zhao, Q., Precision Cancer Center Airport Center, Tianjin Cancer Hospital Airport Hospital, Tianjin, China; Nie, Q., Department of Microbiology, Weifang Center for Disease Control and Prevention, Weifang, China; Li, Y., Hubei Engineering Research Center of Viral Vector, Wuhan University of Bioengineering, Wuhan, China; Foley, B.T., HIV Databases, Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos, NM, United States; Chaillon, A., Department of Medicine, University of California San Diego, La Jolla, CA, United States","To investigate the evolutionary history of the recent outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China, a total of 70 genomes of virus strains from China and elsewhere with sampling dates between 24 December 2019 and 3 February 2020 were analyzed. To explore the potential intermediate animal host of the SARS-CoV-2 virus, we reanalyzed virome data sets from pangolins and representative SARS-related coronaviruses isolates from bats, with particular attention paid to the spike glycoprotein gene. We performed phylogenetic, split network, transmission network, likelihood-mapping, and comparative analyses of the genomes. Based on Bayesian time-scaled phylogenetic analysis using the tip-dating method, we estimated the time to the most recent common ancestor and evolutionary rate of SARS-CoV-2, which ranged from 22 to 24 November 2019 and 1.19 to 1.31 × 10−3 substitutions per site per year, respectively. Our results also revealed that the BetaCoV/bat/Yunnan/RaTG13/2013 virus was more similar to the SARS-CoV-2 virus than the coronavirus obtained from the two pangolin samples (SRR10168377 and SRR10168378). We also identified a unique peptide (PRRA) insertion in the human SARS-CoV-2 virus, which may be involved in the proteolytic cleavage of the spike protein by cellular proteases, and thus could impact host range and transmissibility. Interestingly, the coronavirus carried by pangolins did not have the RRAR motif. Therefore, we concluded that the human SARS-CoV-2 virus, which is responsible for the recent outbreak of COVID-19, did not come directly from pangolins. © 2020 Wiley Periodicals, Inc.",COVID-19; cross-species transmission; evolutionary rate; potential intermediate animal host; SARS-CoV-2; TMRCA,,"Chan, J.F.W., Yuan, S., Kok, K.H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, 395, pp. 514-523. , https://doi.org/10.1016/S0140-6736(20)30154-9; Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med, , https://doi.org/10.1056/NEJMoa2001316; Su, S., Wong, G., Shi, W., Epidemiology, genetic recombination, and pathogenesis of coronaviruses (2016) Trends Microbiol, 24, pp. 490-502. , https://doi.org/10.1016/j.tim.2016.03.003; Drosten, C., Günther, S., Preiser, W., Identification of a novel coronavirus in patients with severe acute respiratory syndrome (2003) N Engl J Med, 348, pp. 1967-1976. , https://doi.org/10.1056/NEJMoa030747; 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Decroly, E., Vandenbranden, M., Ruysschaert, J.M., The convertases furin and PC1 can both cleave the human immunodeficiency virus (HIV)-1 envelope glycoprotein gp160 into gp120 (HIV-1 SU) and gp41 (HIV-I TM) (1994) J Biol Chem, 269, pp. 12240-12247","Li, X.; Hubei Engineering Research Center of Viral Vector, Wuhan University of BioengineeringChina; email: xingguanglee@hotmail.com",,John Wiley and Sons Inc.,1466615,,JMVID,32104911,English,J. Med. Virol.,Article,Article in Press,Open Access,Scopus,2-s2.0-85081322505,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhang T., Wu Q., Zhang Z.",57215874875;57215874460;57215875481;,Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak,2020,Current Biology,,,,,,,,10.1016/j.cub.2020.03.022,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082188927&doi=10.1016%2fj.cub.2020.03.022&partnerID=40&md5=288e7c2b28649733659b7786cf3b7568,"State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Life Sciences, Yunnan University, No. 2 North Cuihu Road, Kunming, Yunnan 650091, China","Zhang, T., State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Life Sciences, Yunnan University, No. 2 North Cuihu Road, Kunming, Yunnan 650091, China; Wu, Q., State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Life Sciences, Yunnan University, No. 2 North Cuihu Road, Kunming, Yunnan 650091, China; Zhang, Z., State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Life Sciences, Yunnan University, No. 2 North Cuihu Road, Kunming, Yunnan 650091, China","An outbreak of coronavirus disease 2019 (COVID-19) caused by the 2019 novel coronavirus (SARS-CoV-2) began in the city of Wuhan in China and has widely spread worldwide. Currently, it is vital to explore potential intermediate hosts of SARS-CoV-2 to control COVID-19 spread. Therefore, we reinvestigated published data from pangolin lung samples from which SARS-CoV-like CoVs were detected by Liu et al. [1]. We found genomic and evolutionary evidence of the occurrence of a SARS-CoV-2-like CoV (named Pangolin-CoV) in dead Malayan pangolins. Pangolin-CoV is 91.02% and 90.55% identical to SARS-CoV-2 and BatCoV RaTG13, respectively, at the whole-genome level. Aside from RaTG13, Pangolin-CoV is the most closely related CoV to SARS-CoV-2. The S1 protein of Pangolin-CoV is much more closely related to SARS-CoV-2 than to RaTG13. Five key amino acid residues involved in the interaction with human ACE2 are completely consistent between Pangolin-CoV and SARS-CoV-2, but four amino acid mutations are present in RaTG13. Both Pangolin-CoV and RaTG13 lost the putative furin recognition sequence motif at S1/S2 cleavage site that can be observed in the SARS-CoV-2. Conclusively, this study suggests that pangolin species are a natural reservoir of SARS-CoV-2-like CoVs. The emerging SARS-coronavirus 2 (SARS-CoV-2) poses tremendous threat to human health. Zhang, Wu et al. show that like bats, pangolin species are a natural reservoir of SARS-CoV-2-like CoVs. 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Methods, 9, pp. 357-359; Li, D., Liu, C.-M., Luo, R., Sadakane, K., Lam, T.-W., MEGAHIT: an ultra-fast single-node solution for large and complex metagenomics assembly via succinct de Bruijn graph (2015) Bioinformatics, 31, pp. 1674-1676; Camacho, C., Coulouris, G., Avagyan, V., Ma, N., Papadopoulos, J., Bealer, K., Madden, T.L., BLAST+: architecture and applications (2009) BMC Bioinformatics, 10, p. 421; Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., Marth, G., Durbin, R., The Sequence Alignment/Map format and SAMtools (2009) Bioinformatics, 25, pp. 2078-2079; Edgar, R.C., MUSCLE: multiple sequence alignment with high accuracy and high throughput (2004) Nucleic Acids Res., 32, pp. 1792-1797; Talavera, G., Castresana, J., Improvement of phylogenies after removing divergent and ambiguously aligned blocks from protein sequence alignments (2007) Syst. Biol., 56, pp. 564-577; Kumar, S., Stecher, G., Li, M., Knyaz, C., Tamura, K., MEGA X: molecular evolutionary genetics analysis across computing platforms (2018) Mol. Biol. Evol., 35, pp. 1547-1549","Zhang, Z.; State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Life Sciences, Yunnan University, No. 2 North Cuihu Road, China; email: zhangzhigang@ynu.edu.cn",,Cell Press,9609822,,CUBLE,,English,Curr. Biol.,Article,Article in Press,Open Access,Scopus,2-s2.0-85082188927,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Cui S., Hao W.",26323522500;57194714773;,Deducing the crystal structure of MERS-CoV helicase,2020,Methods in Molecular Biology,2099,,,69,85,,,10.1007/978-1-0716-0211-9_6,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077340858&doi=10.1007%2f978-1-0716-0211-9_6&partnerID=40&md5=f11fe08393b666caf62540a89f0c7b8b,"NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China","Cui, S., NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China; Hao, W., NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China","RNA virus encodes a helicase essential for viral RNA transcription and replication when the genome size is larger than 7 kb. Coronavirus (CoV) has an exceptionally large RNA genome (~30 kb) and it encodes an essential replicase, the nonstructural protein 13 (nsp13), a member of superfamily 1 helicases. Nsp13 is among the evolutionary most conserved proteins not only in CoVs but also in nidovirales. Thus, it is considered as an important drug target. However, the high-resolution structure of CoV nsp13 remained unavailable even until more than a decade after the outbreak of the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2003, which hindered the structure-based drug design. This is in part due to the intrinsic flexibility of nsp13. Here, we describe protocols of deducing the crystal structure of Middle East respiratory syndrome coronavirus (MERS-CoV) helicase in detail, which include protein expression, purification, crystallization, enzymatic characterization, and structure determination. With these methods, catalytically active recombinant MERS-CoV nsp13 protein can be prepared and crystallized and the crystal structure can be solved. © Springer Science+Business Media, LLC, part of Springer Nature 2020.",Coronavirus; Crystallization; Helicase; nsp13; Structure determination,,"Stadler, K., Masignani, V., Eickmann, M., Becker, S., Abrignani, S., SARS--beginning to understand a new virus (2003) Nat Rev Microbiol, 1, pp. 209-218; Zaki, A.M., van Boheemen, S., Bestebroer, T.M., Osterhaus, A.D., Fouchier, R.A., Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia (2012) N Engl J Med, 367, pp. 1814-1820; Kupferschmidt, K., INFECTIOUS DISEASES. Amid panic, a chance to learn about MERS (2015) Science, 348, pp. 1183-1184; Gorbalenya, A.E., Enjuanes, L., Ziebuhr, J., Snijder, E.J., Nidovirales: Evolving the largest RNA virus genome (2006) Virus Res, 117, pp. 17-37; Lauber, C., Goeman, J.J., Parquet Mdel, C., Nga, P.T., Snijder, E.J., The footprint of genome architecture in the largest genome expansion in RNA viruses (2013) Plos Pathog, 9; Thiel, V., Ivanov, K.A., Putics, A., Hertzig, T., Schelle, B., Mechanisms and enzymes involved in SARS coronavirus genome expression (2003) J Gen Virol, 84, pp. 2305-2315; Subissi, L., Imbert, I., Ferron, F., Collet, A., Cou-Tard, B., SARS-CoV ORF1b-encoded nonstructural proteins 12-16: Replicative enzymes as antiviral targets (2014) Antivir Res, 101, pp. 122-130; Subissi, L., Posthuma, C.C., Collet, A., Zevenhoven-Dobbe, J.C., Gorbalenya, A.E., One severe acute respiratory syndrome coronavirus protein complex integrates proces-sive RNA polymerase and exonuclease activities (2014) Proc Natl Acad Sci U S A, 111, pp. E3900-E3909; Prentice, E., McAuliffe, J., Lu, X., Subbarao, K., Denison, M.R., Identification and characterization of severe acute respiratory syndrome coronavirus replicase proteins (2004) J Virol, 78, pp. 9977-9986; Hao, W., Wojdyla, J.A., Zhao, R., Han, R., Das, R., Crystal structure of Middle East respiratory syndrome coronavirus helicase (2017) Plos Pathog, 13; Gorbalenya, A.E., Koonin, E.V., Viral proteins containing the purine NTP-binding sequence pattern (1989) Nucleic Acids Res, 17, pp. 8413-8440; Deng, Z., Lehmann, K.C., Li, X., Feng, C., Wang, G., Structural basis for the regulatory function of a complex zinc-binding domain in a replicative arterivirus helicase resembling a nonsense-mediated mRNA decay helicase (2014) Nucleic Acids Res, 42, pp. 3464-3477; Ivanov, K.A., Thiel, V., Dobbe, J.C., van der Meer, Y., Snijder, E.J., Multiple enzymatic activities associated with severe acute respiratory syndrome coronavirus helicase (2004) J Virol, 78, pp. 5619-5632; Adedeji, A.O., Lazarus, H., Biochemical characterization of Middle East respiratory syndrome coronavirus helicase (2016) Msphere, 1. , https://doi.org/10.1128/mSphere.00235-16; Hu, Z., Yan, C., Liu, P., Huang, Z., Ma, R., Crystal structure of NLRC4 reveals its autoinhibition mechanism (2013) Science, 341, pp. 172-175; Zlatev, I., Lackey, J.G., Zhang, L., Dell, A., McRae, K., Automated parallel synthesis of 5'-triphosphate oligonucleotides and preparation of chemically modified 5'-triphosphate small interfering RNA (2013) Bioorg Med Chem, 21, pp. 722-732; Zlatev, I., Manoharan, M., Vasseur, J.J., Morvan, F., Solid-phase chemical synthesis of 5-'-triphosphate DNA, RNA, and chemically modified oligonucleotides (2012) Curr Protoc Nucleic Acid Chem. Chapter, 1. , Unit1 28; Cui, S., Eisenacher, K., Kirchhofer, A., Brzozka, K., Lammens, A., The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I (2008) Mol Cell, 29, pp. 169-179; Lee, N.R., Kwon, H.M., Park, K., Oh, S., Jeong, Y.J., Cooperative translocation enhances the unwinding of duplex DNA by SARS coronavirus helicase nsP13 (2010) Nucleic Acids Res, 38, pp. 7626-7636; Vonrhein, C., Blanc, E., Roversi, P., Bricogne, G., Automated structure solution with autoSHARP (2007) Methods Mol Biol, 364, pp. 215-230; Emsley, P., Lohkamp, B., Scott, W.G., Cowtan, K., Features and development of coot (2010) Acta Crystallogr D Biol Crystallogr, 66, pp. 486-501; Adams, P.D., Afonine, P.V., Bunkoczi, G., Chen, V.B., Davis, I.W., PHENIX: A comprehensive python-based system for macromolec-ular structure solution (2010) Acta Crystallogr D Biol Crystallogr, 66, pp. 213-221","Cui, S.; NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical CollegeChina; email: Cui.sheng@ipb.pumc.edu.cn",,Humana Press Inc.,10643745,,,31883088,English,Methods Mol. Biol.,Book Chapter,Final,Open Access,Scopus,2-s2.0-85077340858,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Sun P., Lu X., Xu C., Sun W., Pan B.",57214371381;57212512532;57215415572;57215423230;57215414966;,Understanding of COVID-19 based on current evidence,2020,Journal of Medical Virology,,,,,,,4,10.1002/jmv.25722,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080875858&doi=10.1002%2fjmv.25722&partnerID=40&md5=28ab40b04e51511ded0a991412551180,"Department of Plastic Surgery, Zibo Central Hospital, Zibo, China; Department of Plastic Surgery, Affiliated Hospital of Weifang Medical University, Weifang, China; Department of Medicine, People's Hospital of Boxing, Binzhou, China; Department of Plastic Surgery, Plastic Surgery Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China","Sun, P., Department of Plastic Surgery, Zibo Central Hospital, Zibo, China; Lu, X., Department of Plastic Surgery, Affiliated Hospital of Weifang Medical University, Weifang, China; Xu, C., Department of Plastic Surgery, Zibo Central Hospital, Zibo, China; Sun, W., Department of Medicine, People's Hospital of Boxing, Binzhou, China; Pan, B., Department of Plastic Surgery, Plastic Surgery Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China","Since December 2019, a series of unexplained pneumonia cases have been reported in Wuhan, China. On 12 January 2020, the World Health Organization (WHO) temporarily named this new virus as the 2019 novel coronavirus (2019-nCoV). On 11 February 2020, the WHO officially named the disease caused by the 2019-nCoV as coronavirus disease (COVID-19). The COVID-19 epidemic is spreading all over the world, especially in China. Based on the published evidence, we systematically discuss the characteristics of COVID-19 in the hope of providing a reference for future studies and help for the prevention and control of the COVID-19 epidemic. © 2020 Wiley Periodicals, Inc.",2019-nCoV; coronavirus; COVID-19; epidemiology; pneumonia; SARS-CoV-2,,"Gorbalenya, A.E., Baker, S.C., Baric, R.S., Severe acute respiratory syndrome-related coronavirus: The species and its viruses-a statement of the coronavirus study group (2020) bioRxiv, , https://doi.org/10.1101/2020.02.07.937862; (2020) National Health Commission's briefing on the pneumonia epidemic situation (in Chinese), , http://www.nhc.gov.cn/yjb/s7860/202001/9614b05a8cac4ffabac10c4502fe517c.shtml, Accessed 23 February 2020; Chen, Y., Liu, Q., Guo, D., Emerging coronaviruses: genome structure, replication, and pathogenesis (2020) J Med Virol, 92, pp. 418-423. , https://doi.org/10.1002/jmv.25681; Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382, pp. 727-733. , https://doi.org/10.1056/NEJMoa2001017; Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med, , https://doi.org/10.1056/NEJMoa2001316; Ji, W., Wang, W., Zhao, X., Zai, J., Li, X., Homologous recombination within the spike glycoprotein of the newly identified coronavirus may boost cross-species transmission from snake to human (2020) J Med Virol, 92, pp. 433-440. , https://doi.org/10.1002/jmv.25682; Benvenuto, D., Giovannetti, M., Ciccozzi, A., Spoto, S., Angeletti, S., Ciccozzi, M., The 2019-new coronavirus epidemic: evidence for virus evolution (2020) J Med Virol, , https://doi.org/10.1002/jmv.25688; Chan, J.F.W., Kok, K.H., Zhu, Z., Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan (2020) Emerg Microbes Infect, 9 (1), pp. 221-236. , https://doi.org/10.1080/22221751.2020.1719902; Hui, D.S., I Azhar, E., Madani, T.A., The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health–the latest 2019 novel coronavirus outbreak in Wuhan, China (2020) Int J Infect Dis, 91, pp. 264-266; Zhou, P., Yang, X.L., Wang, X.G., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature, , https://doi.org/10.1038/s41586-020-2012-7; Wu, F., Zhao, S., Yu, B., A new coronavirus associated with human respiratory disease in China (2020) Nature, , https://doi.org/10.1038/s41586-020-2008-3; Wang, W., Tang, J., Wei, F., Updated understanding of the outbreak of 2019 novel coronavirus (2019-nCoV) in Wuhan, China (2020) J Med Virol, , https://doi.org/10.1002/jmv.25689; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506. , https://doi.org/10.1016/S0140-6736(20)30183-5; Wu, P., Hao, X., Lau, E.H.Y., Real-time tentative assessment of the epidemiological characteristics of novel coronavirus infections in Wuhan, China, as at 22 January 2020 (2020) Euro Surveill, 25 (3); Zhao, Y., Zhao, Z., Wang, Y., Single-cell RNA expression profiling of ACE2, the putative receptor of Wuhan 2019-nCov (2020) bioRxiv, , https://doi.org/10.1101/2020.01.26.919985; Wrapp, D., Wang, N., Corbett, K.S., Cryo-EM structure of the SARS-CoV-2 spike in the prefusion conformation (2020) medRxiv, , https://doi.org/10.1101/2020.02.11.944462; Guan, W., Ni, Z., Hu, Y., Clinical characteristics of 2019 novel coronavirus infection in China (2020) medRxiv, , https://doi.org/10.1101/2020.02.06.20020974; Holshue, M.L., DeBolt, C., Lindquist, S., First case of 2019 novel coronavirus in the United States (2020) N Engl J Med, , https://doi.org/10.1056/NEJMoa2001191; Lu, H., Drug treatment options for the 2019-new coronavirus (2019-nCoV) (2020) Biosci Trends, , https://doi.org/10.5582/bst.2020.01020; Yang, Y., Lu, Q.-B., Liu, M.-J., Epidemiological and clinical features of the 2019 novel coronavirus outbreak in China (2020) medRxiv, , https://doi.org/10.1101/2020.02.10.20021675; Wong, G., Liu, W., Liu, Y., Zhou, B., Bi, Y., Gao, G.F., MERS, SARS, and Ebola: the role of super-spreaders in infectious disease (2015) Cell Host Microbe, 18 (4), pp. 398-401; Rothe, C., Schunk, M., Sothmann, P., Transmission of 2019-nCoV infection from an asymptomatic contact in Germany (2020) N Engl J Med, , https://doi.org/10.1056/NEJMc2001468; Sheng, G., Chen, P., Wei, Y., Viral infection increases the risk of idiopathic pulmonary fibrosis: a meta-analysis (2019) Chest, , https://doi.org/10.1016/j.chest.2019.10.032","Pan, B.; Department of Plastic Surgery, Plastic Surgery Hospital, Peking Union Medical College, Chinese Academy of Medical SciencesChina; email: zbzbzhc@163.com",,John Wiley and Sons Inc.,1466615,,JMVID,32096567,English,J. Med. Virol.,Review,Article in Press,Open Access,Scopus,2-s2.0-85080875858,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Hoffmann M., Kleine-Weber H., Schroeder S., Krüger N., Herrler T., Erichsen S., Schiergens T.S., Herrler G., Wu N.-H., Nitsche A., Müller M.A., Drosten C., Pöhlmann S.",35080416400;57204592347;57196021608;55934578000;20733821600;57215872747;35520242900;7006339246;57215875494;7004626809;24068857400;7003813990;57210095234;,SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor,2020,Cell,,,,,,,7,10.1016/j.cell.2020.02.052,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082190084&doi=10.1016%2fj.cell.2020.02.052&partnerID=40&md5=a549c04ed86e9a113811e0f95610e9f4,"Infection Biology Unit, German Primate Center – Leibniz Institute for Primate Research, Göttingen, Germany; Faculty of Biology and Psychology, University Göttingen, Göttingen, Germany; Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Virology, Berlin, Germany; German Centre for Infection Research, associated partner Charité, Berlin, Germany; Institute of Virology, University of Veterinary Medicine Hannover, Hannover, Germany; Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, Hannover, Germany; BG Unfallklinik Murnau, Murnau, Germany; Institute for Biomechanics, BG Unfallklinik Murnau, Murnau, Germany; Institute for Biomechanics, Paracelsus Medical University Salzburg, Salzburg, Austria; Biobank of the Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich, Germany; Robert Koch Institute, ZBS 1 Highly Pathogenic Viruses, WHO Collaborating Centre for Emerging Infections and Biological Threats, Berlin, Germany; Martsinovsky Institute of Medical Parasitology, Tropical and Vector Borne Diseases, Sechenov University, Moscow, Russian Federation","Hoffmann, M., Infection Biology Unit, German Primate Center – Leibniz Institute for Primate Research, Göttingen, Germany; Kleine-Weber, H., Infection Biology Unit, German Primate Center – Leibniz Institute for Primate Research, Göttingen, Germany, Faculty of Biology and Psychology, University Göttingen, Göttingen, Germany; Schroeder, S., Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Virology, Berlin, Germany, German Centre for Infection Research, associated partner Charité, Berlin, Germany; Krüger, N., Institute of Virology, University of Veterinary Medicine Hannover, Hannover, Germany, Research Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, Hannover, Germany; Herrler, T., BG Unfallklinik Murnau, Murnau, Germany; Erichsen, S., Institute for Biomechanics, BG Unfallklinik Murnau, Murnau, Germany, Institute for Biomechanics, Paracelsus Medical University Salzburg, Salzburg, Austria; Schiergens, T.S., Biobank of the Department of General, Visceral, and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich, Germany; Herrler, G., Institute of Virology, University of Veterinary Medicine Hannover, Hannover, Germany; Wu, N.-H., Institute of Virology, University of Veterinary Medicine Hannover, Hannover, Germany; Nitsche, A., Robert Koch Institute, ZBS 1 Highly Pathogenic Viruses, WHO Collaborating Centre for Emerging Infections and Biological Threats, Berlin, Germany; Müller, M.A., Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Virology, Berlin, Germany, German Centre for Infection Research, associated partner Charité, Berlin, Germany, Martsinovsky Institute of Medical Parasitology, Tropical and Vector Borne Diseases, Sechenov University, Moscow, Russian Federation; Drosten, C., Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Virology, Berlin, Germany, German Centre for Infection Research, associated partner Charité, Berlin, Germany; Pöhlmann, S., Infection Biology Unit, German Primate Center – Leibniz Institute for Primate Research, Göttingen, Germany, Faculty of Biology and Psychology, University Göttingen, Göttingen, Germany","The recent emergence of the novel, pathogenic SARS-coronavirus 2 (SARS-CoV-2) in China and its rapid national and international spread pose a global health emergency. Cell entry of coronaviruses depends on binding of the viral spike (S) proteins to cellular receptors and on S protein priming by host cell proteases. Unravelling which cellular factors are used by SARS-CoV-2 for entry might provide insights into viral transmission and reveal therapeutic targets. Here, we demonstrate that SARS-CoV-2 uses the SARS-CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming. A TMPRSS2 inhibitor approved for clinical use blocked entry and might constitute a treatment option. Finally, we show that the sera from convalescent SARS patients cross-neutralized SARS-2-S-driven entry. Our results reveal important commonalities between SARS-CoV-2 and SARS-CoV infection and identify a potential target for antiviral intervention. The emerging SARS-coronavirus 2 (SARS-CoV-2) threatens public health. Hoffmann and coworkers show that SARS-CoV-2 infection depends on the host cell factors ACE2 and TMPRSS2 and can be blocked by a clinically proven protease inhibitor. These findings might help to establish options for prevention and treatment. © 2020 Elsevier Inc.",ACE2; coronavirus; COVID-19; entry; neutralization; priming; SARS-CoV-2; spike; TMPRSS2,,"Berger Rentsch, M., Zimmer, G., A vesicular stomatitis virus replicon-based bioassay for the rapid and sensitive determination of multi-species type I interferon (2011) PLoS ONE, 6, p. e25858; Bertram, S., Glowacka, I., Blazejewska, P., Soilleux, E., Allen, P., Danisch, S., Steffen, I., Schneider, H., TMPRSS2 and TMPRSS4 facilitate trypsin-independent spread of influenza virus in Caco-2 cells (2010) J. 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Virol., 89, pp. 9119-9123; Yeager, C.L., Ashmun, R.A., Williams, R.K., Cardellichio, C.B., Shapiro, L.H., Look, A.T., Holmes, K.V., Human aminopeptidase N is a receptor for human coronavirus 229E (1992) Nature, 357, pp. 420-422; Zhou, Y., Vedantham, P., Lu, K., Agudelo, J., Carrion, R., Jr., Nunneley, J.W., Barnard, D., Simmons, G., Protease inhibitors targeting coronavirus and filovirus entry (2015) Antiviral Res., 116, pp. 76-84; Zhou, P., Yang, X.L., Wang, X.G., Hu, B., Zhang, L., Zhang, W., Si, H.R., Huang, C.L., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature; Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., Zhao, X., Lu, R., A Novel Coronavirus from Patients with Pneumonia in China, 2019 (2020) N Engl J Med., 382, pp. 727-733","Hoffmann, M.; Infection Biology Unit, German Primate Center – Leibniz Institute for Primate ResearchGermany; email: mhoffmann@dpz.eu",,Cell Press,928674,,CELLB,32142651,English,Cell,Article,Article in Press,Open Access,Scopus,2-s2.0-85082190084,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Dey S.K., Rahman M.M., Siddiqi U.R., Howlader A.",56523905800;57212184188;35771719900;57215777454;,Analyzing the epidemiological outbreak of COVID-19: A visual exploratory data analysis approach,2020,Journal of Medical Virology,,,,,,,1,10.1002/jmv.25743,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081898447&doi=10.1002%2fjmv.25743&partnerID=40&md5=79e247e37cb00933d723a3b6958183c3,"Department of Computer Science and Engineering, Dhaka International University (DIU), Dhaka, Bangladesh; Department of Computer Science and Engineering, Military Institute of Science and Technology (MIST), Mirpur Cantonment, Dhaka, Bangladesh; Department of Physiology, Shaheed Suhrawardy Medical College (ShSMC), Dhaka, Bangladesh; Department of Computer and Communication Engineering, Patuakhali Science and Technology University (PSTU), Dumki, Bangladesh","Dey, S.K., Department of Computer Science and Engineering, Dhaka International University (DIU), Dhaka, Bangladesh; Rahman, M.M., Department of Computer Science and Engineering, Military Institute of Science and Technology (MIST), Mirpur Cantonment, Dhaka, Bangladesh; Siddiqi, U.R., Department of Physiology, Shaheed Suhrawardy Medical College (ShSMC), Dhaka, Bangladesh; Howlader, A., Department of Computer and Communication Engineering, Patuakhali Science and Technology University (PSTU), Dumki, Bangladesh","There is an obvious concern globally regarding the fact about the emerging coronavirus 2019 novel coronavirus (2019-nCoV) as a worldwide public health threat. As the outbreak of COVID-19 causes by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) progresses within China and beyond, rapidly available epidemiological data are needed to guide strategies for situational awareness and intervention. The recent outbreak of pneumonia in Wuhan, China, caused by the SARS-CoV-2 emphasizes the importance of analyzing the epidemiological data of this novel virus and predicting their risks of infecting people all around the globe. In this study, we present an effort to compile and analyze epidemiological outbreak information on COVID-19 based on the several open datasets on 2019-nCoV provided by the Johns Hopkins University, World Health Organization, Chinese Center for Disease Control and Prevention, National Health Commission, and DXY. An exploratory data analysis with visualizations has been made to understand the number of different cases reported (confirmed, death, and recovered) in different provinces of China and outside of China. Overall, at the outset of an outbreak like this, it is highly important to readily provide information to begin the evaluation necessary to understand the risks and begin containment activities. © 2020 Wiley Periodicals, Inc.",China; coronavirus; COVID-19; data analysis; SARS-CoV-2; visualization,,"Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382, pp. 727-733. , https://doi.org/10.1056/NEJMoa2001017; Drosten, C., Günther, S., Preiser, W., Identification of a novel coronavirus associated with severe acute respiratory syndrome (2003) N Engl J Med, 348, pp. 1967-1976; Chen, Y., Liu, Q., Guo, D., Emerging coronaviruses: genome structure, replication, and pathogenesis (2020) J Med Virol, 92, pp. 418-423. , https://doi.org/10.1002/jmv.25681; Novel Coronavirus, , http://www.who.int/csr/don/12-january-2020-novel-coronavirus-china/en/, China January 12, 2020, Accessed 19 January 2020; Hui, D.S., I Azhar, E., Madani, T.A., The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health—the latest 2019 novel coronavirus outbreak in Wuhan, China (2020) Int J Infect Dis, 2020 (91), pp. 264-266; Lu, H., Stratton, C.W., Tang, Y.W., Outbreak of pneumonia of unknown etiology in Wuhan China: the mystery and the miracle (2020) J Med Virol, 92, pp. 401-402. , https://doi.org/10.1002/jmv.25678; (2019), https://www.cdc.gov/coronavirus/2019-nCoV/summary.html, Centers for Disease Control and Prevention. 2019 Novel Coronavirus (2019-nCoV), Wuhan, China; Ji, W., Wang, W., Zhao, X., Zai, J., Li, X., Cross-species transmission of the newly identified coronavirus 2019-nCoV (2020) J Med Virol, 92, pp. 433-440. , https://doi.org/10.1002/jmv.25682; Yoo, J.H., The fight against the 2019-nCoV outbreak: an arduous march has just begun (2020) J Korean Med Sci, 35. , https://doi.org/10.3346/jkms.2020.35.e56; Gorbalenya, A.E., Baker, S.C., Baric, R.S., Acute respiratory syndrome-related coronavirus: the species and its viruses-a statement of the Coronavirus Study Group [published online ahead of print February 11, 2020] (2020) bioRxiv, , https://doi.org/10.1101/2020.02.07.937862; Lauren, G., (2020) Coronavirus COVID-19 Global Cases by Johns Hopkins CSSE, , https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html, January 23, Accessed 16 February 2020","Dey, S.K.; Department of Computer Science and Engineering, Dhaka International University (DIU)Bangladesh; email: sopnil.samrat@gmail.com",,John Wiley and Sons Inc.,1466615,,JMVID,32124990,English,J. Med. Virol.,Article,Article in Press,Open Access,Scopus,2-s2.0-85081898447,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Ye G., Wang X., Tong X., Shi Y., Fu Z.F., Peng G.",57141715200;57215594381;57211873763;55481317400;7403347700;56651662900;,Structural basis for inhibiting porcine epidemic diarrhea virus replication with the 3C-Like protease inhibitor GC376,2020,Viruses,12,2,240,,,,,10.3390/v12020240,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081265688&doi=10.3390%2fv12020240&partnerID=40&md5=661a0ffe8eeaace514a8acb37b7c9932,"State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 430070, China; Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, United States","Ye, G., State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; Wang, X., State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; Tong, X., State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; Shi, Y., State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; Fu, Z.F., State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 430070, China, Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, United States; Peng, G., State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 430070, China","Porcine epidemic diarrhea virus (PEDV), being highly virulent and contagious in piglets, has caused significant damage to the pork industries of many countries worldwide. There are no commercial drugs targeting coronaviruses (CoVs), and few studies on anti-PEDV inhibitors. The coronavirus 3C-like protease (3CLpro) has a conserved structure and catalytic mechanism and plays a key role during viral polyprotein processing, thus serving as an appealing antiviral drug target. Here, we report the anti-PEDV effect of the broad-spectrum inhibitor GC376 (targeting 3Cpro or 3CLpro of viruses in the picornavirus-like supercluster). GC376 was highly effective against the PEDV 3CLpro and exerted similar inhibitory effects on two PEDV strains. Furthermore, the structure of the PEDV 3CLpro in complex with GC376 was determined at 1.65 Å. We elucidated structural details and analyzed the differences between GC376 binding with the PEDV 3CLpro and GC376 binding with the transmissible gastroenteritis virus (TGEV) 3CLpro. Finally, we explored the substrate specificity of PEDV 3CLpro at the P2 site and analyzed the effects of Leu group modification in GC376 on inhibiting PEDV infection. This study helps us to understand better the PEDV 3CLpro substrate specificity, providing information on the optimization of GC376 for development as an antiviral therapeutic against coronaviruses. © 2020 by the authors.",Complex; Coronavirus; Crystal structure; Inhibitor; PEDV 3CLpro,"antivirus agent; GC376; peptide hydrolase; proteinase inhibitor; pyrrolidine derivative; animal; chemistry; Chlorocebus aethiops; drug effect; enzyme active site; enzyme specificity; enzymology; metabolism; molecular model; physiology; Porcine epidemic diarrhea virus; Transmissible gastroenteritis virus; Vero cell line; virus replication; X ray crystallography; Animals; Antiviral Agents; Catalytic Domain; Chlorocebus aethiops; Crystallography, X-Ray; Models, Molecular; Peptide Hydrolases; Porcine epidemic diarrhea virus; Protease Inhibitors; Pyrrolidines; Substrate Specificity; Transmissible gastroenteritis virus; Vero Cells; Virus Replication","Oldham, J., Letter to the editor (1972) Pig Farming, 10, pp. 72-73; Song, D., Moon, H., Kang, B., Porcine epidemic diarrhea: A review of current epidemiology and available vaccines (2015) Clin. 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Res., 97, pp. 161-168","Peng, G.; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural UniversityChina; email: penggq@mail.hzau.edu.cn",,MDPI AG,19994915,,,32098094,English,Viruses,Article,Final,Open Access,Scopus,2-s2.0-85081265688,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Ibrahim I.M., Abdelmalek D.H., Elshahat M.E., Elfiky A.A.",57208274428;57208273478;57215782014;37067188100;,COVID-19 spike-host cell receptor GRP78 binding site prediction,2020,Journal of Infection,,,,,,,2,10.1016/j.jinf.2020.02.026,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080979697&doi=10.1016%2fj.jinf.2020.02.026&partnerID=40&md5=b37530eb243fcb23122147331b96fb9f,"Biophysics Department, Faculty of Sciences, Cairo University, Giza, Egypt; College of Applied Medical Sciences, University of Al-Jouf, Saudi Arabia","Ibrahim, I.M., Biophysics Department, Faculty of Sciences, Cairo University, Giza, Egypt; Abdelmalek, D.H., Biophysics Department, Faculty of Sciences, Cairo University, Giza, Egypt; Elshahat, M.E., Biophysics Department, Faculty of Sciences, Cairo University, Giza, Egypt; Elfiky, A.A., Biophysics Department, Faculty of Sciences, Cairo University, Giza, Egypt, College of Applied Medical Sciences, University of Al-Jouf, Saudi Arabia","Objectives: Understanding the novel coronavirus (COVID-19) mode of host cell recognition may help to fight the disease and save lives. The spike protein of coronaviruses is the main driving force for host cell recognition. Methods: In this study, the COVID-19 spike binding site to the cell-surface receptor (Glucose Regulated Protein 78 (GRP78)) is predicted using combined molecular modeling docking and structural bioinformatics. The COVID-19 spike protein is modeled using its counterpart, the SARS spike. Results: Sequence and structural alignments show that four regions, in addition to its cyclic nature have sequence and physicochemical similarities to the cyclic Pep42. Protein-protein docking was performed to test the four regions of the spike that fit tightly in the GRP78 Substrate Binding Domain β (SBDβ). The docking pose revealed the involvement of the SBDβ of GRP78 and the receptor-binding domain of the coronavirus spike protein in recognition of the host cell receptor. Conclusions: We reveal that the binding is more favorable between regions III (C391-C525) and IV (C480-C488) of the spike protein model and GRP78. Region IV is the main driving force for GRP78 binding with the predicted binding affinity of -9.8 kcal/mol. These nine residues can be used to develop therapeutics specific against COVID-19. © 2020",BiP; COVID-19 spike; GRP78; Pep42; Protein-protein docking; Structural bioinformatics,,"Hui, D.S., I Azhar, E., Madani, T.A., Ntoumi, F., Kock, R., Dar, O., (2020) Int J Infect Dis, 91, pp. 264-266; Bogoch, I.I., Watts, A., Thomas-Bachli, A., Huber, C., Kraemer, M.U.G., Khan, K., Pneumonia of unknown etiology in Wuhan, China: potential for international spread via commercial air travel (2020) J Travel Med; Surveillance case definitions for human infection with novel coronavirus ( nCoV): interim guidance v1, January 2020 (2020), World Health Organization; Laboratory testing of human suspected cases of novel coronavirus ( nCoV) infection: interim guidance, 10 January 2020 (2020), World Health Organization; Infection prevention and control during health care when novel coronavirus ( nCoV) infection is suspected: interim guidance, January 2020 (2020), World Health Organization; Parr, J., Pneumonia in China: lack of information raises concerns among Hong Kong health workers (2020), British Medical Journal Publishing Group; Yang, L., China confirms human-to-human transmission of coronavirus (2020); Elfiky, A.A., Mahdy, S.M., Elshemey, W.M., Quantitative structure-activity relationship and molecular docking revealed a potency of anti-hepatitis C virus drugs against human corona viruses (2017) J Med Virol, 89 (6), pp. 1040-1047; Chan, J.F., Lau, S.K., To, K.K., Cheng, V.C., Woo, P.C., Yuen, K.-Y., Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease (2015) Clin Microbiol Rev, 28 (2), pp. 465-522; WHO. 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Saunders Ltd,1634453,,JINFD,32169481,English,J. Infect.,Article,Article in Press,Open Access,Scopus,2-s2.0-85080979697,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wu Y.-C., Chen C.-S., Chan Y.-J.",57215776289;57215776233;33667461800;,The outbreak of COVID-19: An overview,2020,Journal of the Chinese Medical Association,83,3,,217,220,,2,10.1097/JCMA.0000000000000270,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081350216&doi=10.1097%2fJCMA.0000000000000270&partnerID=40&md5=fe14d156904bf9b7c0aa882d00dfb51e,"Division of Microbiology, Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Division of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Public Health, School of Medicine, National Yang-Ming University, Taipei, Taiwan","Wu, Y.-C., Division of Microbiology, Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Chen, C.-S., Division of Microbiology, Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Chan, Y.-J., Division of Microbiology, Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Division of Infectious Diseases, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Institute of Public Health, School of Medicine, National Yang-Ming University, Taipei, Taiwan","In late December 2019, a previous unidentified coronavirus, currently named as the 2019 novel coronavirus#, emerged from Wuhan, China, and resulted in a formidable outbreak in many cities in China and expanded globally, including Thailand, Republic of Korea, Japan, United States, Philippines, Viet Nam, and our country (as of 2/6/2020 at least 25 countries). The disease is officially named as Coronavirus Disease-2019 (COVID-19, by WHO on February 11, 2020). It is also named as Severe Pneumonia with Novel Pathogens on January 15, 2019 by the Taiwan CDC, the Ministry of Health and is a notifiable communicable disease of the fifth category. COVID-19 is a potential zoonotic disease with low to moderate (estimated 2%-5%) mortality rate. Person-to-person transmission may occur through droplet or contact transmission and if there is a lack of stringent infection control or if no proper personal protective equipment available, it may jeopardize the first-line healthcare workers. Currently, there is no definite treatment for COVID-19 although some drugs are under investigation. To promptly identify patients and prevent further spreading, physicians should be aware of the travel or contact history of the patient with compatible symptoms. Copyright © 2020, the Chinese Medical Association. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)",Coronavirus; COVID-19; Outbreak; Pneumonia; Zoonosis,"antivirus agent; remdesivir; virus vaccine; COVID-19; severe acute respiratory syndrome coronavirus 2; antiviral therapy; clinical feature; coronavirus disease 2019; Coronavirus infection; coughing; dyspnea; epidemic; fatigue; fever; hemoptysis; human; infection; infection prevention; nonhuman; Review; rhinorrhea; SARS coronavirus; severe acute respiratory syndrome coronavirus 2; sore throat; thorax pain; virology; Asia; Betacoronavirus; China; Coronavirus infection; disease transmission; global health; infection control; pathogenicity; procedures; United States; virus pneumonia; Asia; Betacoronavirus; China; Coronavirus Infections; Global Health; Humans; Infection Control; Infectious Disease Transmission, Patient-to-Professional; Pneumonia, Viral; United States","Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Lancet, 2020; 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Interim Guidelines for Environmental Cleaning and Disinfection of Areas Exposed to Confirmed Case(S) of 2019 Novel Coronavirus (2019-nCoV) in Non-Healthcare Commercial Premises, , https://www.nea.gov.sg/, Accessed February 7, 2020; Hand Hygiene for Health Workers Caring for Ebola Patients, , https://www.who.int/csr/disease/ebola/hand-hygiene/en/, Accessed February 7, 2020","Chan, Y.-J.; Division of Microbiology, Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, 201, Section 2, Shi-Pai Road, Taiwan; email: yjchan@vghtpe.gov.tw",,Wolters Kluwer Health,17264901,,JCMAB,32049687,English,J. Chin. Med. Assoc.,Review,Final,Open Access,Scopus,2-s2.0-85081350216,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Chen W.-H., Strych U., Hotez P.J., Bottazzi M.E.",57202839336;6602996116;7004958298;6603937133;,The SARS-CoV-2 Vaccine Pipeline: an Overview,2020,Current Tropical Medicine Reports,,,,,,,,10.1007/s40475-020-00201-6,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081614187&doi=10.1007%2fs40475-020-00201-6&partnerID=40&md5=6594991fc09fbadf108d82da2827020e,"Texas Children’s Hospital Center for Vaccine Development, Departments of Pediatrics and Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, United States","Chen, W.-H., Texas Children’s Hospital Center for Vaccine Development, Departments of Pediatrics and Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, United States; Strych, U., Texas Children’s Hospital Center for Vaccine Development, Departments of Pediatrics and Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, United States; Hotez, P.J., Texas Children’s Hospital Center for Vaccine Development, Departments of Pediatrics and Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, United States; Bottazzi, M.E., Texas Children’s Hospital Center for Vaccine Development, Departments of Pediatrics and Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, TX, United States","Purpose of Review: The goal of this review is to provide a timely overview on efforts to develop a vaccine for the 2019 novel coronavirus SARS-CoV-2, the causative agent of coronavirus disease (COVID-19). Recent Findings: Previous research efforts to develop a severe acute respiratory syndrome coronavirus (SARS-CoV) vaccine in the years following the 2003 pandemic have opened the door for investigators to design vaccine concepts and approaches for the COVID-19 epidemic in China. Both SARS-CoV and SARS-CoV-2 exhibit a high degree of genetic similarity and bind to the same host cell ACE2 receptor. Based on previous experience with SARS-CoV vaccines, it is expected that all COVID-19 vaccines will require careful safety evaluations for immunopotentiation that could lead to increased infectivity or eosinophilic infiltration. Besides this, a COVID-19 vaccine target product profile must address vaccinating at-risk human populations including frontline healthcare workers, individuals over the age of 60, and those with underlying and debilitating chronic conditions. Among the vaccine technologies under evaluation are whole virus vaccines, recombinant protein subunit vaccines, and nucleic acid vaccines. Summary: Each current vaccine strategy has distinct advantages and disadvantages. Therefore, it is paramount that multiple strategies be advanced quickly and then evaluated for safety and efficacy. Ultimately, the safety studies to minimize undesired immunopotentiation will become the most significant bottleneck in terms of time. © 2020, Springer Nature Switzerland AG.",Coronavirus; COVID-19; RBD; Receptor binding domain; Wuhan virus,,"Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med, , https://doi.org/10.1056/NEJMoa2001316; (2020) WHO Director-General’s Remarks at the Media Briefing on 2019-Ncov on 11 February 2020, , https://www.who.int/dg/speeches/detail/who-director-general-s-remarks-at-the-media-briefing-on-2019-ncov-on-11-february-2020, Accessed February 13, 2020; Rothe, C., Schunk, M., Sothmann, P., Bretzel, G., Froeschl, G., Wallrauch, C., Transmission of 2019-nCoV infection from an asymptomatic contact in Germany (2020) N Engl J Med, , https://doi.org/10.1056/NEJMc2001468; Hoffmann, M., Kleine-Weber, H., Krüger, N., Müller, M., Drosten, C., Pöhlmann, S., (2020) The novel coronavirus 2019 (2019-nCoV) uses the SARS-coronavirus receptor ACE2 and the cellular protease TMPRSS2 for entry into target cells, , https://doi.org/10.1101/2020.01.31.929042, 2020.01.31.929042; Zhou, P., Yang, X.-L., Wang, X.-G., Hu, B., Zhang, L., Zhang, W., (2020) Discovery of a Novel Coronavirus Associated with the Recent Pneumonia Outbreak in Humans and Its Potential Bat Origin, , https://doi.org/10.1101/2020.01.22.914952, 2020.01.22.914952; Wu, F., Zhao, S., Yu, B., Chen, Y.-M., Wang, W., Hu, Y., (2020) Complete genome characterisation of a novel coronavirus associated with severe human respiratory disease in Wuhan, , https://doi.org/10.1101/2020.01.24.919183, China, 2020.01.24.919183; Jiang, S., Bottazzi, M.E., Du, L., Lustigman, S., Tseng, C.T., Curti, E., Roadmap to developing a recombinant coronavirus S protein receptor-binding domain vaccine for severe acute respiratory syndrome (2012) Expert Rev Vaccines, 11 (12), pp. 1405-1413; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Cao, B., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) The Lancet, 395 (10223), pp. 497-506; Pong, W., A dozen vaccine programs under way as WHO declares coronavirus public health emergency (2020) Biocentury, , https://www.biocentury.com/article/304328/industry-and-academic-centers-are-rushing-to-create-new-vaccines-and-therapeutics-targeting-coronavirus, Accessed 28 Feb 2020; (2020), https://www.jnj.com/coronavirus, Accessed February 10, 2020; (2020) Codagenix and Serum Institute of India Initiate Co-Development of a Scalable, Live-Attenuated Vaccine against the 2019 Novel Coronavirus, COVID-19, , https://www.biospace.com/article/releases/codagenix-and-serum-institute-of-india-initiate-co-development-of-a-scalable-live-attenuated-vaccine-against-the-2019-novel-coronavirus-covid-19/, Accessed 2/13/2020; Hennessy, J., Australia’s been asked to make a coronavirus vaccine at ‘unprecedented speed’ (2020) Science Alert, , https://www.sciencealert.com/australian-scientists-asked-to-make-coronavirus-vaccine-at-unprecedented-speed, Accessed 28 Feb 2020; Pharmaceutical Technology N. Coronavirus: Vir Biotechnology and Novavax Announce Vaccine Plans. 2020, , https://www.pharmaceutical-technology.com/news/coronavirus-vir-biotechnology-novavax-vaccine/, Accessed 28 Feb 2020; (2020) Clover Initiates Development of Recombinant Subunit-Trimer Vaccine for Wuhan Coronavirus (2019-Ncov); Mukherjee, S., The first coronavirus drug candidate is set for testing in China (2020) Fortune, , https://fortune.com/2020/02/03/coronavirus-vaccine-testing-in-china/, Accessed 28 Feb 2020; (2020) Vaxart Announces Initiation of Coronavirus Vaccine Program, , https://pipelinereview.com/index.php/2020020273689/Vaccines/Vaxart-Announces-Initiation-of-Coronavirus-Vaccine-Program.html, Vaxart. PipelineReview.com; (2020) Inovio Collaborating with Beijing Advaccine to Advance INO-4800 Vaccine against New Coronavirus in China, , http://ir.inovio.com/news-and-media/news/press-release-details/2020/Inovio-Collaborating-With-Beijing-Advaccine-To-Advance-INO-4800-Vaccine-Against-New-Coronavirus-In-China/default.aspx, Accessed 28 Feb 2020; Park, A., Inside the Company That's Hot-wiring Vaccine Research in the Race to Combat the Coronavirus (2020) Time, , https://time.com/5775784/coronavirus-vaccine-research/, Accessed 28 Feb 2020; Smith, J., (2020) Curevac Bids to Develop First Mrna Coronavirus Vaccine, , https://www.labiotech.eu/medical/curevac-coronavirus-outbreak-cepi/, Accessed 28 Feb 2020; J&J Working on Coronavirus Vaccine. Thepharmaletter 2020, , https://www.thepharmaletter.com/article/j-j-working-on-coronavirus-vaccine, Accessed 28 Feb 2020; National Institutes of Health, , https://clinicaltrials.gov/ct2/show/NCT02543567, Accessed February 7, 2020; Cheung, E., China coronavirus: Hong Kong researchers have already developed vaccine but need time to test it, expert reveals South China Morning Post., , https://www.scmp.com/news/hong-kong/health-environment/article/3047956/china-coronavirus-hong-kong-researchers-have, Accessed 28 Feb 2020; Shieber, J., Codagenix Raises $20 Million for a New Flu Vaccine and Other Therapies, , https://techcrunch.com/2020/01/13/codagenix-raises-20-million-for-a-new-flu-vaccine-and-other-therapies/, Tech Crunch, Accessed 28 Feb 2020; Coleman, C.M., Liu, Y.V., Mu, H., Taylor, J.K., Massare, M., Flyer, D.C., Glenn, G.M., Frieman, M.B., Purified coronavirus spike protein nanoparticles induce coronavirus neutralizing antibodies in mice (2014) Vaccine, 32 (26), pp. 3169-3174; Chen, W.H., Chag, S.M., Poongavanam, M.V., Biter, A.B., Ewere, E.A., Rezende, W., Optimization of the production process and characterization of the yeast-expressed SARS-CoV recombinant receptor-binding domain (RBD219-N1), a SARS vaccine candidate (2017) J Pharm Sci, 106 (8), pp. 1961-1970; Chen, W.H., Du, L., Chag, S.M., Ma, C., Tricoche, N., Tao, X., Yeast-expressed recombinant protein of the receptor-binding domain in SARS-CoV spike protein with deglycosylated forms as a SARS vaccine candidate (2014) Hum Vaccines Immunother, 10 (3), pp. 648-658. , COI: 1:CAS:528:DC%2BC2cXitVCltb%2FP","Bottazzi, M.E.; Texas Children’s Hospital Center for Vaccine Development, Departments of Pediatrics and Molecular Virology & Microbiology, National School of Tropical Medicine, Baylor College of MedicineUnited States; email: bottazzi@bcm.edu",,Springer,21963045,,,,English,Curr. Trop. Med. Rep.,Review,Article in Press,Open Access,Scopus,2-s2.0-85081614187,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhang Q., Wang Y., Qi C., Shen L., Li J.",57214953921;57194243599;57033538400;57215423369;55854013200;,Clinical trial analysis of 2019-nCoV therapy registered in China,2020,Journal of Medical Virology,,,,,,,2,10.1002/jmv.25733,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080921550&doi=10.1002%2fjmv.25733&partnerID=40&md5=33d3271d81617e1009c5e6e2e6238914,"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China","Zhang, Q., Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China; Wang, Y., Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China; Qi, C., Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China; Shen, L., Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China; Li, J., Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and Institute, Beijing, China","So far, there is a lack of effective drugs for the new coronavirus pneumonia. With more and more patients diagnosed, China has carried out more than 100 clinical studies of new coronavirus infection, including antiviral drugs, antimalarial drugs, glucocorticoids, plasma therapy, virus vaccine, and other Western drugs, while Chinese medicine research accounted for half of the studies. Most of the trials were initiated by investigators and the study period would last for 1 to 11 months. The primary endpoints included symptom improvement and virus nucleic acid turning negative, but the optimal endpoint has not been determined. Although the final results of studies will take a long time to complete, the interim research data may provide some help for the current urgent demand for drug treatment. Compared with that of during SARS period in 2003, China has the stronger capability to carry out clinical trials of new drugs in emergency period. © 2020 Wiley Periodicals, Inc.",China; clinical trial; new coronavirus pneumonia; new drugs,,"Chung, M., Bernheim, A., Mei, X., CT imaging features of 2019 novel coronavirus (2019-nCoV) (2020) Radiology; Corman, V.M., Landt, O., Kaiser, M., Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR (2020) Euro Surveill, 25 (3); Liang, W., Guan, W., Chen, R., Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China (2020) Lancet Oncol, S1470-2045 (1420); Stockman, L.J., Bellamy, R., Garner, P., SARS: systematic review of treatment effects (2006) PLOS Med, 3 (9); Shen, L., Niu, J., Wang, C., High-throughput screening and identification of potent broad-spectrum inhibitors of coronaviruses (2019) J Virol, 93 (12); Cohen, J., Can an anti-HIV combination or other existing drugs outwit the new coronavirus? (2020) Science; Cohen, J., Scientists are moving at record speed to create new coronavirus vaccines—But they may come too late (2020) Science; Vincent, M.J., Bergeron, E., Benjannet, S., Chloroquine is a potent inhibitor of SARS coronavirus infection and spread (2005) Virol J, 2, p. 69; Holshue, M.L., DeBolt, C., Lindquist, S., First case of 2019 novel coronavirus in the United States (2020) N Engl J Med, , https://doi.org/10.1056/NEJMoa2001191","Li, J.; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Oncology, Peking University Cancer Hospital and InstituteChina; email: oncogene@163.com",,John Wiley and Sons Inc.,1466615,,JMVID,32108352,English,J. Med. Virol.,Note,Article in Press,Open Access,Scopus,2-s2.0-85080921550,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Bittar C., Machado R.R.G., Comelis M.T., Bueno L.M., Beguelini M.R., Morielle-Versute E., Nogueira M.L., Rahal P.",25951189700;57204626627;56201389600;55955506700;25654701700;6602261667;7102536040;6603624814;,"Alphacoronavirus Detection in Lungs, Liver, and Intestines of Bats from Brazil",2020,Microbial Ecology,79,1,,203,212,,,10.1007/s00248-019-01391-x,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85071612752&doi=10.1007%2fs00248-019-01391-x&partnerID=40&md5=a8b8a08a9dad578bc397964cd1f5f6f7,"Instituto de Biociências, Letras e Ciências Exatas (IBILCE), Universidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP) - Campus de São José do Rio Preto, Rua Cristóvão Colombo, 2265, Jardim Nazareth, São Jose do Rio Preto, SP 15054-000, Brazil; Centro das Ciências Biológicas e da Saúde (CCBS), Universidade Federal do Oeste da Bahia (UFOB), Rua Professor José Seabra de Lemos, 316, Recanto dos Pássaros, Barreiras, BA 47808-021, Brazil; Faculdade de Medicina de São José do Rio Preto (FAMERP), Avenida Brigadeiro Faria Lima, 5416, Vila São Pedro, Sao Jose do Rio Preto, SP 15090-000, Brazil","Bittar, C., Instituto de Biociências, Letras e Ciências Exatas (IBILCE), Universidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP) - Campus de São José do Rio Preto, Rua Cristóvão Colombo, 2265, Jardim Nazareth, São Jose do Rio Preto, SP 15054-000, Brazil; Machado, R.R.G., Instituto de Biociências, Letras e Ciências Exatas (IBILCE), Universidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP) - Campus de São José do Rio Preto, Rua Cristóvão Colombo, 2265, Jardim Nazareth, São Jose do Rio Preto, SP 15054-000, Brazil; Comelis, M.T., Instituto de Biociências, Letras e Ciências Exatas (IBILCE), Universidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP) - Campus de São José do Rio Preto, Rua Cristóvão Colombo, 2265, Jardim Nazareth, São Jose do Rio Preto, SP 15054-000, Brazil; Bueno, L.M., Instituto de Biociências, Letras e Ciências Exatas (IBILCE), Universidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP) - Campus de São José do Rio Preto, Rua Cristóvão Colombo, 2265, Jardim Nazareth, São Jose do Rio Preto, SP 15054-000, Brazil; Beguelini, M.R., Instituto de Biociências, Letras e Ciências Exatas (IBILCE), Universidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP) - Campus de São José do Rio Preto, Rua Cristóvão Colombo, 2265, Jardim Nazareth, São Jose do Rio Preto, SP 15054-000, Brazil, Centro das Ciências Biológicas e da Saúde (CCBS), Universidade Federal do Oeste da Bahia (UFOB), Rua Professor José Seabra de Lemos, 316, Recanto dos Pássaros, Barreiras, BA 47808-021, Brazil; Morielle-Versute, E., Instituto de Biociências, Letras e Ciências Exatas (IBILCE), Universidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP) - Campus de São José do Rio Preto, Rua Cristóvão Colombo, 2265, Jardim Nazareth, São Jose do Rio Preto, SP 15054-000, Brazil; Nogueira, M.L., Faculdade de Medicina de São José do Rio Preto (FAMERP), Avenida Brigadeiro Faria Lima, 5416, Vila São Pedro, Sao Jose do Rio Preto, SP 15090-000, Brazil; Rahal, P., Instituto de Biociências, Letras e Ciências Exatas (IBILCE), Universidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP) - Campus de São José do Rio Preto, Rua Cristóvão Colombo, 2265, Jardim Nazareth, São Jose do Rio Preto, SP 15054-000, Brazil","Bats are flying mammals distributed worldwide known to host several types of Coronavirus (CoV). Since they were reported as the probable source of spillover of highly pathogenic CoV into the human population, investigating the circulation of this virus in bats around the world became of great importance. We analyzed samples from 103 bats from two distinct regions in Brazil. Coronavirus from the Alphacoronavirus genus was detected in 12 animals, 11 from São José do Rio Preto—SP region and 1 from Barreiras—BA region, resulting in a prevalence of 17.18% and 2.56% respectively. The virus was detected not only in intestines but also in lungs and liver. Phylogenetic analysis based on nsP12 genomic region suggests that the sequences group according to host family and sampling location. Studies on the circulation of these viruses in bats remain important to understand the ecology and evolutionary relationship of these pathogens. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.",Alphacoronavirus; Bats; Coronavirus; Phylogeny,Alphacoronavirus; animal experiment; article; Brazil; ecology; genus; infectious agent; intestine; liver; lung; nonhuman; phylogeny; prevalence; sampling,"Adams, M.J., Carstens, E.B., Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses (2012) (2012) Arch Virol, 157, pp. 1411-1422; Weiss, S.R., Navas-Martin, S., Coronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome coronavirus (2005) Microbiol Mol Biol Rev: MMBR, 69, pp. 635-664; Coleman, C.M., Frieman, M.B., Coronaviruses: important emerging human pathogens (2014) J Virol, 88, pp. 5209-5212; Zaki, A.M., van Boheemen, S., Bestebroer, T.M., Osterhaus, A.D.M.E., Fouchier, R.A.M., Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia (2012) New England Journal of Medicine, 367 (19), pp. 1814-1820; Drosten, C., Gunther, S., Preiser, W., van der Werf, S., Brodt, H.R., Becker, S., Rabenau, H., Doerr, H.W., Identification of a novel coronavirus in patients with severe acute respiratory syndrome (2003) N Engl J Med, 348, pp. 1967-1976; Feldhamer, G.A., Drickamer, L.C., Vessey, S.H., Merritt, J.F., Krajewski, C., (2005) Mammalogy: adaptation, diversity, ecology, , Johns Hopkins University Press, Baltimore; Nogueira, M.R., IPd, L., Moratelli, R., Tavares, V.C., Gregorin, R., Peracchi, A.L., Checklist of Brazilian bats, with comments on original records (2014) Check List, 10, pp. 808-821; Wilson, D.E.R.D., (2005) Mammal species of the world: a taxonomic and geographic reference, , Johns Hopkins University Press, Baltimore; Luis, A.D., Hayman, D.T., O'Shea, T.J., Cryan, P.M., Gilbert, A.T., Pulliam, J.R., Mills, J.N., Webb, C.T., A comparison of bats and rodents as reservoirs of zoonotic viruses: are bats special? 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(2016) Biota Neotropica, 16. , (,),., https://doi.org/10.1590/1676-0611-BN-2015-0026","Bittar, C.; Instituto de Biociências, Letras e Ciências Exatas (IBILCE), Universidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP) - Campus de São José do Rio Preto, Rua Cristóvão Colombo, 2265, Jardim Nazareth, Brazil; email: cibittar@gmail.com",,Springer,953628,,MCBEB,31144002,English,Microb. Ecol.,Article,Final,Open Access,Scopus,2-s2.0-85071612752,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wang C., Liu Z., Chen Z., Huang X., Xu M., He T., Zhang Z.",56571703400;57210418873;57215840560;57215847796;57215845959;57215841722;56571635100;,The establishment of reference sequence for SARS-CoV-2 and variation analysis,2020,Journal of Medical Virology,,,,,,,,10.1002/jmv.25762,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082028740&doi=10.1002%2fjmv.25762&partnerID=40&md5=94714c3253c5f324b09e3bd78efe88df,"Department of Infectious Diseases, The Second Hospital of Anhui Medical University, Hefei, China; Institute of Clinical Virology, The Second Hospital of Anhui Medical University, Hefei, China; Department of Infectious Diseases, The Affiliated Anqing Hospital of Anhui Medical University, Anqing, China; Anhui Provincial Laboratory of Inflammatory and Immunity Disease, Anhui Medical University, Hefei, China","Wang, C., Department of Infectious Diseases, The Second Hospital of Anhui Medical University, Hefei, China, Institute of Clinical Virology, The Second Hospital of Anhui Medical University, Hefei, China, Department of Infectious Diseases, The Affiliated Anqing Hospital of Anhui Medical University, Anqing, China; Liu, Z., Department of Infectious Diseases, The Second Hospital of Anhui Medical University, Hefei, China, Institute of Clinical Virology, The Second Hospital of Anhui Medical University, Hefei, China; Chen, Z., Institute of Clinical Virology, The Second Hospital of Anhui Medical University, Hefei, China; Huang, X., Institute of Clinical Virology, The Second Hospital of Anhui Medical University, Hefei, China; Xu, M., Department of Infectious Diseases, The Second Hospital of Anhui Medical University, Hefei, China, Institute of Clinical Virology, The Second Hospital of Anhui Medical University, Hefei, China; He, T., Department of Infectious Diseases, The Second Hospital of Anhui Medical University, Hefei, China, Institute of Clinical Virology, The Second Hospital of Anhui Medical University, Hefei, China; Zhang, Z., Department of Infectious Diseases, The Second Hospital of Anhui Medical University, Hefei, China, Institute of Clinical Virology, The Second Hospital of Anhui Medical University, Hefei, China, Anhui Provincial Laboratory of Inflammatory and Immunity Disease, Anhui Medical University, Hefei, China","Starting around December 2019, an epidemic of pneumonia, which was named COVID-19 by the World Health Organization, broke out in Wuhan, China, and is spreading throughout the world. A new coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by the Coronavirus Study Group of the International Committee on Taxonomy of Viruses was soon found to be the cause. At present, the sensitivity of clinical nucleic acid detection is limited, and it is still unclear whether it is related to genetic variation. In this study, we retrieved 95 full-length genomic sequences of SARAS-CoV-2 strains from the National Center for Biotechnology Information and GISAID databases, established the reference sequence by conducting multiple sequence alignment and phylogenetic analyses, and analyzed sequence variations along the SARS-CoV-2 genome. The homology among all viral strains was generally high, among them, 99.99% (99.91%-100%) at the nucleotide level and 99.99% (99.79%-100%) at the amino acid level. Although overall variation in open-reading frame (ORF) regions is low, 13 variation sites in 1a, 1b, S, 3a, M, 8, and N regions were identified, among which positions nt28144 in ORF 8 and nt8782 in ORF 1a showed mutation rate of 30.53% (29/95) and 29.47% (28/95), respectively. These findings suggested that there may be selective mutations in SARS-COV-2, and it is necessary to avoid certain regions when designing primers and probes. Establishment of the reference sequence for SARS-CoV-2 could benefit not only biological study of this virus but also diagnosis, clinical monitoring and intervention of SARS-CoV-2 infection in the future. © 2020 Wiley Periodicals, Inc.",homology; nucleotide; reference sequence; SARS-CoV-2; variation,,"Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506; Lu, R., Zhao, X., Li, J., Genomic characterization and epidemiology of 2019 novel coronavirus: implications of virus origins and receptor binding (2020) Lancet, 395, pp. 565-574. , https://doi.org/10.1016/S0140-6736(20)30251-8; Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382, pp. 727-733; (2020), http://www.nhc.gov.cn, (Assessed on March 8th; (2020), https://www.who.int, (accessed March 8th; The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in china (2020) Chin J Epidemiol, 41, pp. 145-151; Chan, J.F.W., Yuan, S., Kok, K.H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, 395, pp. 514-523; Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med, , https://doi.org/10.1056/NEJMoa2001316; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395, pp. 507-513; Guan, W.J., Ni, Z., Hu, Y., Clinical characteristics of 2019 novel coronavirus infection in China (2020) medRxiv, , https://doi.org/10.1101/2020.02.06.20020974; Wu, F., Zhao, S., Yu, B., A new coronavirus associated with human respiratory disease in China (2020) Nature, 579, pp. 265-269; Su, S., Wong, G., Shi, W., Epidemiology, genetic recombination, and pathogenesis of coronaviruses (2016) Trends Microbiol, 24, pp. 490-502; Cheng, V.C., Lau, S.K., Woo, P.C., Yuen, K.Y., Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection (2007) Clin Microbiol Rev, 20, pp. 660-694; Chan, J.F.W., Lau, S.K.P., To, K.K.W., Cheng, V.C.C., Woo, P.C.Y., Yuen, K., Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease (2015) Clin Microbiol Rev, 28, pp. 465-522; Zhang, N., Wang, L., Deng, X., Recent advances in the detection of respiratory virus infection in humans (2020) J Med Virol, 92 (4), pp. 408-417; Chu, D., Pan, Y., Cheng, S., Molecular diagnosis of a novel coronavirus (2019-nCoV) causing an outbreak of pneumonia (2020) Clin Chem; Corman, V.M., Landt, O., Kaiser, M., Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR (2020) Euro Surveill, 25; Zhou, P., Yang, X., Wang, X., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature, 579, pp. 270-273; Xiao, K.P., Zhai, J.P., Feng, Y.Y., Isolation and characterization of 2019-nCoV-like coronavirus from Malayan pangolins (2020) bioRxiv, , https://doi.org/10.1101/2020.02.17.951335; Lam, T., Shum, M., Zhu, H.Z., Identification of 2019-nCoV related coronaviruses in Malayan pangolins in southern China (2020) bioRxiv, , https://doi.org/10.1101/2020.02.13.945485; Chen, L., Shi, Y., Yang, W., Differences in Cpg island distribution between subgenotypes of the hepatitis B virus genotype (2018) Med Sci Monitor, 24, pp. 6781-6794; Zhang, Z., Xia, J., Sun, B., In vitro and in vivo replication of a chemically synthesized consensus genome of hepatitis B virus genotype B (2015) J Virol Methods, 213, pp. 57-64; Chan, J.F.W., Kok, K.H., Zhu, Z., Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan (2020) Emerg Microbes Infec, 9, pp. 221-236; Wang, S., Bo, K., Ma, J.L., A deep learning algorithm using CT images to screen for Corona Virus Disease (COVID-19) (2020) medRxiv, , https://doi.org/10.1101/2020.02.14.20023028","Zhang, Z.; Department of Infectious Diseases, The Second Hospital of Anhui Medical UniversityChina; email: zzh1974cn@163.com",,John Wiley and Sons Inc.,1466615,,JMVID,32167180,English,J. Med. Virol.,Article,Article in Press,Open Access,Scopus,2-s2.0-85082028740,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Fang Y., Nie Y., Penny M.",57215719915;57215721215;57215720288;,Transmission dynamics of the COVID-19 outbreak and effectiveness of government interventions: A data-driven analysis,2020,Journal of Medical Virology,,,,,,,,10.1002/jmv.25750,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081740101&doi=10.1002%2fjmv.25750&partnerID=40&md5=8177034c4f27d95ad1627be1bdc7da8a,"School of Public Health, Hangzhou Medical College, Hangzhou, China; Graduate School, Harbin Medical University, Harbin, China; Department of Public Health Sciences, California Baptist University, Riverside, CA, United States","Fang, Y., School of Public Health, Hangzhou Medical College, Hangzhou, China; Nie, Y., Graduate School, Harbin Medical University, Harbin, China; Penny, M., Department of Public Health Sciences, California Baptist University, Riverside, CA, United States","Using the parameterized susceptible-exposed-infectious-recovered model, we simulated the spread dynamics of coronavirus disease 2019 (COVID-19) outbreak and impact of different control measures, conducted the sensitivity analysis to identify the key factor, plotted the trend curve of effective reproductive number (R), and performed data fitting after the simulation. By simulation and data fitting, the model showed the peak existing confirmed cases of 59 769 arriving on 15 February 2020, with the coefficient of determination close to 1 and the fitting bias 3.02%, suggesting high precision of the data-fitting results. More rigorous government control policies were associated with a slower increase in the infected population. Isolation and protective procedures would be less effective as more cases accrue, so the optimization of the treatment plan and the development of specific drugs would be of more importance. There was an upward trend of R in the beginning, followed by a downward trend, a temporary rebound, and another continuous decline. The feature of high infectiousness for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) led to an upward trend, and government measures contributed to the temporary rebound and declines. The declines of R could be exploited as strong evidence for the effectiveness of the interventions. Evidence from the four-phase stringent measures showed that it was significant to ensure early detection, early isolation, early treatment, adequate medical supplies, patients’ being admitted to designated hospitals, and comprehensive therapeutic strategy. Collaborative efforts are required to combat the novel coronavirus, focusing on both persistent strict domestic interventions and vigilance against exogenous imported cases. © 2020 Wiley Periodicals, Inc.",basic reproductive number; COVID-19; data fitting; data simulation; effective reproductive number; effectiveness; intervention; SARS-CoV-2; SEIR; sensitivity analysis; transmission,,"Li, Q., An Outbreak of NCIP (2019-nCoV) Infection in China—Wuhan, Hubei Province, 2019-2020 (2020) China CDC Weekly, 2 (5), pp. 79-80; Tan, W.J., Zhao, X., Ma, X.J., A novel coronavirus genome identified in a cluster of pneumonia cases—Wuhan, China 2019−2020 (2020) China CDC Wkly, 2 (4), pp. 61-62. , http://weekly.chinacdc.cn/en/article/ccdcw/2020/4/61; WHO Director-General's remarks at the media briefing on 2019-nCoV on 11 February 2020, , https://www.who.int/dg/speeches/detail/who-director-general-s-remarks-at-the-media-briefing-on-2019-ncov-on-11-february-2020, Accessed February 11, 2020; Zhou, P., Yang, X.L., Wang, X.G., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature, , https://doi.org/10.1038/s41586-020-2012-7; 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Lipsitch, M., Cohen, T., Cooper, B., Transmission dynamics and control of severe acute respiratory syndrome (2003) Science, 300 (5627), pp. 1966-1970; Read, J.M., Bridgen, J.R.E., Cummings, D.A.T., Ho, A., Jewell, C.P., Novel coronavirus 2019-nCoV: early estimation of epidemiological parameters and epidemic predictions (2020) medRxiv, , https://doi.org/10.1101/2020.01.23.20018549, Preprint online January 24, 2020; Wu, J.T., Leung, K., Leung, G.M., Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study (2020) Lancet, 395, pp. 689-697; https://www.nature.com/articles/d41586-020-00154-w, Coronavirus latest scientists scramble to study virus samples., Accessed February 4, 2020; Zhao, S., Lin, Q., Ran, J., Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: a data-driven analysis in the early phase of the outbreak (2020) Int J Infect Dis, 92, pp. 214-217; Ma, Z.E., Zhou, Y.C., Wang, W.D., (2004) Mathematical Modeling of Epidemic Dynamics, , Beijing, China, Science Press; Qian, G., Mahdi, A., Sensitivity analysis methods in the biomedical sciences (2020) Math Biosci, , https://doi.org/10.1016/j.mbs.2020.108306; Wallinga, J., Lipsitch, M., How generation intervals shape the relationship between growth rates and reproductive numbers (2007) Proc R Soc B, 274, pp. 599-604; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan,China (2020) Lancet, 395 (10223), pp. 497-506. , https://doi.org/10.1016/S0140-6736(20)30183-5; The progress of COVID-19 by Wuhan Health Commission, , http://www.chinanews.com/shipin/2019/12-31/news843209.shtml, Accessed February 5, 2020; Chan, J.F., Yuan, S., Kok, K.H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, 395, pp. 514-523; Xie, Z., Data fitting and scenario analysis of vaccination in the 2014 Ebola outbreak in Liberia (2019) Osong Public Health Res Perspect, 10 (3), pp. 187-201; National Health Commssion: the average latency of 2019-nCoV is about 7 days, , http://www.chinanews.com/gn/2020/01-22/9067014.shtml, Accessed February 2, 2020; http://news.sina.com.cn/c/2020-02-01/doc-iimxxste8097489.shtml, Beijing has discharged nine patients with pneumonia infected with the new coronavirus, with an average stay of 10.25 days., Accessed February 3, 2020; http://cnews.chinadaily.com.cn/a/202002/24/WS5e531de4a3107bb6b57a1bef.html, Several provinces have downgraded public health emergency response level., Accessed February 28, 2020; The updates of COVID-19 as of 17 February, , http://www.nhc.gov.cn/xcs/yqtb/20200/261f72a74be14c4db6e1b582133cf4b7.shtml, 2020., Accessed March 3, 2020; Getz, W.M., Salter, R., Mgbara, W., Adequacy of SEIR models when epidemics have spatial structure: Ebola in Sierra Leone (2019) Philos Trans R Soc Lond B Biol Sci, 374 (1775); Press Conference of 2019-nCoV by National Health Commission of People's Republic of China, , http://www.most.gov.cn/kjbgz/202002/t20200205_151401.htm, Accessed February 4, 2020; Wang, D., Hu, B., Hu, C., Clinical characteristics of 138 hospitalized patients with 2019 Novel coronavirus-infected pneumonia in Wuhan, China (2020) JAMA, , https://doi.org/10.1001/jama.2020.1585; Jin, Y.H., Cai, L., Cheng, Z.S., A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version) (2020) Mil Med Res, 7 (1), p. 4; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506; Delamater, P.L., Street, E.J., Leslie, T.F., Yang, Y.T., Jacobsen, K.H., Complexity of the basic reproduction number (R0) (2019) Emerging Infect Dis, 25, pp. 1-4; More novel coronavirus cases reported daily outside China than inside: WHO, , https://www.hindustantimes.com/world-news/coronavirus-outbreak-update-more-novel-coronavirus-cases-reported-daily-outside-china-than-inside-who/story-VN2iFxRjbD2C7rAIr1eVUP.html, Accessed February 28, 2020; CDC confirms possible instance of community spread of COVID-19 in U.S., , https://www.cdc.gov/media/releases/2020/s0226-Covid-19-spread.html, Accessed February 28, 2020; The diagnosis and treatment plan for NCIP, , http://www.gov.cn/zhengce/zhengceku/2020-02/05/content_5474791.htm, Accessed February 5, 2020","Fang, Y.; School of Public Health, Hangzhou Medical CollegeChina; email: colourwind1035@126.com",,John Wiley and Sons Inc.,1466615,,JMVID,32141624,English,J. Med. Virol.,Article,Article in Press,Open Access,Scopus,2-s2.0-85081740101,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Andreeva A., Nikolaeva O., Altynbekov O., Galieva C., Ilina K.",57203966712;57203970087;57203976257;57204631948;57215414666;,Influence of interferon-based drugs on immunological indices in specific prevention,2020,Veterinary World,13,2,,238,244,,,10.14202/vetworld.2020.238-244,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080853784&doi=10.14202%2fvetworld.2020.238-244&partnerID=40&md5=bde5de98d5c0f2baa0ef1b19b721f6ce,"Department of Infectious Diseases, Zoohygiene and Veterinary Sanitary Inspection of Federal State Budget Educational, Institution of Higher Education “Bashkir State Agrarian University”, Ufa, Republic Bashkortostan, 450001, Russian Federation","Andreeva, A., Department of Infectious Diseases, Zoohygiene and Veterinary Sanitary Inspection of Federal State Budget Educational, Institution of Higher Education “Bashkir State Agrarian University”, Ufa, Republic Bashkortostan, 450001, Russian Federation; Nikolaeva, O., Department of Infectious Diseases, Zoohygiene and Veterinary Sanitary Inspection of Federal State Budget Educational, Institution of Higher Education “Bashkir State Agrarian University”, Ufa, Republic Bashkortostan, 450001, Russian Federation; Altynbekov, O., Department of Infectious Diseases, Zoohygiene and Veterinary Sanitary Inspection of Federal State Budget Educational, Institution of Higher Education “Bashkir State Agrarian University”, Ufa, Republic Bashkortostan, 450001, Russian Federation; Galieva, C., Department of Infectious Diseases, Zoohygiene and Veterinary Sanitary Inspection of Federal State Budget Educational, Institution of Higher Education “Bashkir State Agrarian University”, Ufa, Republic Bashkortostan, 450001, Russian Federation; Ilina, K., Department of Infectious Diseases, Zoohygiene and Veterinary Sanitary Inspection of Federal State Budget Educational, Institution of Higher Education “Bashkir State Agrarian University”, Ufa, Republic Bashkortostan, 450001, Russian Federation","Aim: The research aimed to study the effect of interferon (IFN)-based drugs on the behavior of immunological parameters in calves during the specific prevention of associative infections. Materials and Methods: The object of research was 45 black motley cows and their calves from birth to 2 months of life. Serum and colostrum samples were screened for antibodies against Rotavirus, diarrhea, and coronavirus using serological methods. The testing was performed before vaccination, 40 days before calving, 20 days before calving, and before calving. Colostrum samples were taken during the first milk yield. Serum samples from calves were drawn before colostrum feeding as well as at 7, 14, and 21 days, and 1 and 2 months of age. To measure the level of immunoglobulins A, M, and G, additional serum samples were collected from calves at 25, 35, 65, and 75 days after birth. Results: Giving pregnant cows, an IFN-based drug at a dose of 1 ml/kg 48 h before vaccination results in the development and accumulation of antibodies to Rotavirus, coronavirus, and viral diarrhea (VD) in the colostrum, with a titer of 7.6±0.3 log2, 5.8±0.34 log2, and 4.4±0.18 log2, respectively. It indicates an increase in the antigenic activity of the multivalent vaccine. Conclusion: IFN-based drugs enhance the protective effect of vaccination against associative infections in the newborn calves. They stimulate a rise in the titer of antibodies to Rotavirus, coronavirus, VD, and mucosal disease complex as well as an increase in immunoglobulins A, M, and G. © Copyright: Andreeva, et al. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/ by/4.0/)","Antibody titer; Coronavirus; Immunoglobulins A, M, and G; Interferon; Rotavirus; Vaccinations",,"Abuelo, A., Havrlant, P., Wood, N., Hernandez-Jover, M., An investigation of dairy calf management practices, colostrum quality, failure of transfer of passive immunity, and occurrence of enteropathogens among Australian dairy farms (2019) J. Dairy Sci., 102 (9), pp. 8352-8366; Ahlenstiel, G., Edlich, B., Hogdal, L.J., Rotman, Y., Noureddin, M., Feld, J.J., Holz, L.E., Rehermann, B., Early changes in natural killer cell function indicate virologic response to interferon therapy for hepatitis C (2011) Gastroenterology, 141 (4), pp. 1231-1239; Khaziahmetov, F., Khabirov, A., Avzalov, R., Tsapalova, G., Tagirov, K., Giniyatullin, S., Andreeva, A., Gafarov, F., Effects of Paenibacillus-based probiotic (bacispecin) on growth performance, gut microflora and hematology indices in goslings (2018) J. Eng. Appl., 13 (8), pp. 6541-6545; Li, S., Zhao, F., Shao, J., Xie, Y., Chang, H., Interferon-omega: Current status in clinical applications (2017) Int. Immunopharmacol., 52, pp. 253-260. , Nov; Yang, J., Pu, Y.G., Zeng, Z.M., Yu, Z.J., Huang, N., Deng, Q.W., Interferon for the treatment of genital warts: A systematic review (2009) BMC Infect. Dis., 21 (9), p. 156; Julander, J.G., Ennis, J., Turner, J., Morrey, J.D., Treatment of yellow fever virus with adenovirus-vectored interferon in a hamster model (2011) Antimicrob. Agents Chemother., 55 (5), pp. 2067-2073; Pirozhkov, M.K., Lenev, S.V., Viktorova, E.V., Strel'Chenko, S.A., Tihonov, L.I., Skljarov, O.D., Diagnostika, specificheskaja profilaktika i lechenie pri virusnyh i bakterial'nyh boleznjah zhivotnyh (2011) Veterinarija, 1, pp. 24-28; Krylov, V.P., Pashkin, A.V., Sochnev, V.V., Sistema upravlenija zdorov'em novorozhdennyh teljat (2006) Vet. Patol., 1 (16), pp. 31-34; Kim, Y., Thapa, M., Hua, D.H., Chang, K.O., Biodegradable nanogels for oral delivery of interferon for norovirus infection (2011) Antiviral Res, 89 (2), pp. 165-173; Safonov, V., Biological role of selenium and correction effects of its content in the organism of animals (2018) Geochem. Int., 56 (10), pp. 1046-1050; Joklik, V.K., Interferony (1989) Virology, pp. 35-88. , Filds, B. and Najn, D., editors. Mir, Moscow; An, D., Yongli, G., Bao, J., Luo, X., Liu, Y., Ma, B., Gao, M., Wang, J., Molecular characterization and biological activity of bovine interferon-omega3 (2017) Res. Vet. Sci., 115, pp. 125-131. , Dec; Floris, S., Ruuls, S.R., Wierinckx, A., Pol, S.M., Döpp, E., Meide, P.H., Dijkstra, C.D., de Vries, H.E., Interferon-h directly influences monocyte infiltration into the central nervous system (2002) J. Neuroimmunol., 127 (1-2), pp. 69-79; Bukholm, G., Degre, M., Whitaker-Dowling, P., Interferon treatment reduces endocytosis of virus and facultatively intracellular Bacteria in various cell lines (1990) J. Interferon Res., 10 (1), pp. 83-89; Dec, M., Puchalski, A., Pol, J., Use of oromucosally administered interferon-alpha in the prevention and treatment of animal diseases (2008) Vet. Sci., 11 (2), pp. 175-186; Andersen, S.H., Vervelde, L., Sutton, K., Norup, L.R., Wattrang, E., Juul-Madsen, H.R., Dalgaard, T.S., Quantification and phenotypic characterisation of peripheral IFN-γ producing leucocytes in chickens vaccinated against Newcastle disease (2017) Vet. Immunol. Immunopathol., 193-194, pp. 18-28. , Dec; Pestka, S., The interferons: 50 years after their discovery, there is much more to learn (2007) J. Biol. Chem., 282 (28), pp. 20047-20051","Andreeva, A.; Department of Infectious Diseases, Zoohygiene and Veterinary Sanitary Inspection of Federal State Budget Educational, Institution of Higher Education “Bashkir State Agrarian University”Russian Federation; email: alandreeva98@yahoo.com",,Veterinary World,9728988,,,,English,Vet. World,Article,Final,Open Access,Scopus,2-s2.0-85080853784,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Favalli E.G., Ingegnoli F., De Lucia O., Cincinelli G., Cimaz R., Caporali R.",6602431714;6602755270;6506544537;57200965375;57214379465;35369730800;,"COVID-19 infection and rheumatoid arthritis: Faraway, so close!",2020,Autoimmunity Reviews,,,102523,,,,,10.1016/j.autrev.2020.102523,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082504080&doi=10.1016%2fj.autrev.2020.102523&partnerID=40&md5=5fd4dd303fcc3c3e652c62c9d7572496,"Division of Clinical Rheumatology, ASST Gaetano Pini-CTO Institute, Milan, Italy; Department of Clinical Sciences and Community Health, Research Center for Adult and Pediatric Rheumatic Diseases, Università degli Studi di Milano, Milano, Italy; Division of Pediatric Rheumatology, ASST Gaetano Pini-CTO Institute, Milan, Italy","Favalli, E.G., Division of Clinical Rheumatology, ASST Gaetano Pini-CTO Institute, Milan, Italy; Ingegnoli, F., Division of Clinical Rheumatology, ASST Gaetano Pini-CTO Institute, Milan, Italy, Department of Clinical Sciences and Community Health, Research Center for Adult and Pediatric Rheumatic Diseases, Università degli Studi di Milano, Milano, Italy; De Lucia, O., Division of Clinical Rheumatology, ASST Gaetano Pini-CTO Institute, Milan, Italy; Cincinelli, G., Department of Clinical Sciences and Community Health, Research Center for Adult and Pediatric Rheumatic Diseases, Università degli Studi di Milano, Milano, Italy; Cimaz, R., Department of Clinical Sciences and Community Health, Research Center for Adult and Pediatric Rheumatic Diseases, Università degli Studi di Milano, Milano, Italy, Division of Pediatric Rheumatology, ASST Gaetano Pini-CTO Institute, Milan, Italy; Caporali, R., Division of Clinical Rheumatology, ASST Gaetano Pini-CTO Institute, Milan, Italy, Department of Clinical Sciences and Community Health, Research Center for Adult and Pediatric Rheumatic Diseases, Università degli Studi di Milano, Milano, Italy","The outbreak of the new coronavirus infections COVID-19 in December 2019 in China has quickly become a global health emergency. Given the lack of specific anti-viral therapies, the current management of severe acute respiratory syndrome coronaviruses (SARS-CoV-2) is mainly supportive, even though several compounds are now under investigation for the treatment of this life-threatening disease. COVID-19 pandemic is certainly conditioning the treatment strategy of a complex disorder as rheumatoid arthritis (RA), whose infectious risk is increased compared to the general population because of an overall impairment of immune system typical of autoimmune diseases combined with the iatrogenic effect generated by corticosteroids and immunosuppressive drugs. However, the increasing knowledge about the pathophysiology of SARS-CoV-2 infection is leading to consider some anti-rheumatic drugs as potential treatment options for the management of COVID-19. In this review we will critically analyse the evidences on either positive or negative effect of drugs commonly used to treat RA in this particular scenario, in order to optimize the current approach to RA patients. © 2020 Elsevier B.V.",Coronavirus; COVID-19; Cytokine release syndrome; DMARDs; Rheumatoid arthritis; Treatment,,"Zhou, P., Yang, X.-L., Wang, X.-G., Hu, B., Zhang, L., Zhang, W., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature, 579, pp. 270-273; Tang, X., Wu, C., Li, X., Song, Y., Yao, X., Wu, X., On the origin and continuing evolution of SARS-CoV-2 (2020) Natl Sci Rev; Wu, Z., McGoogan, J.M., Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention (2020) Jama, 323; Zhang, J.-J., Dong, X., Cao, Y.-Y., Yuan, Y.-D., Yang, Y.-B., Yan, Y.-Q., Clinical characteristics of 140 patients infected by SARS-CoV-2 in Wuhan, China (2020) Allergy; Guan, W.-J., Ni, Z.-Y., Hu, Y., Liang, W.-H., Ou, C.-Q., He, J.-X., Clinical characteristics of coronavirus disease 2019 in China (2020) New Engl J Medicine; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet Lond Engl, 395, pp. 497-506; Yang, X., Yu, Y., Xu, J., Shu, H., Xia, J., Liu, H., Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study (2020) Lancet Respir Med; https://experience.arcgis.com/experience/685d0ace521648f8a5beeeee1b9125cd, (Accessed 17th March 2020); Favalli, E.G., Biggioggero, M., Meroni, P.L., Methotrexate for the treatment of rheumatoid arthritis in the biologic era: still an “anchor” drug? 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(2019) Autoimmun Rev, 18, p. 102399","Favalli, E.G.; Division of Clinical Rheumatology, ASST Gaetano Pini-CTO Institute, Via Gaetano Pini, 9, Italy; email: enniofavalli@me.com",,Elsevier B.V.,15689972,,ARUEB,32205186,English,Autoimmun. Rev.,Review,Article in Press,Open Access,Scopus,2-s2.0-85082504080,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Prajapat M., Sarma P., Shekhar N., Avti P., Sinha S., Kaur H., Kumar S., Bhattacharyya A., Kumar H., Bansal S., Medhi B.",57205574202;35915494500;57215851339;8294435500;56421123100;57211922804;56768466400;57195480497;57208162408;57209820808;6602803991;,Drug targets for corona virus: A systematic review,2020,Indian Journal of Pharmacology,52,1,,56,65,,,10.4103/ijp.IJP_115_20,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082092285&doi=10.4103%2fijp.IJP_115_20&partnerID=40&md5=81a6974f6fe124d5ff9a2955c8e86aef,"Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India; Department of Biophysics, Postgraduate Institute of Medical Education and Research, Chandigarh, India; Department of Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, India","Prajapat, M., Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India; Sarma, P., Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India; Shekhar, N., Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India; Avti, P., Department of Biophysics, Postgraduate Institute of Medical Education and Research, Chandigarh, India; Sinha, S., Department of Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, India; Kaur, H., Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India; Kumar, S., Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India; Bhattacharyya, A., Department of Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, India; Kumar, H., Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India; Bansal, S., Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India; Medhi, B., Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India","The 2019-novel coronavirus (nCoV) is a major source of disaster in the 21th century. However, the lack of specific drugs to prevent/treat an attack is a major need at this current point of time. In this regard, we conducted a systematic review to identify major druggable targets in coronavirus (CoV). We searched PubMed and RCSB database with keywords HCoV, NCoV, corona virus, SERS-CoV, MERS-CoV, 2019-nCoV, crystal structure, X-ray crystallography structure, NMR structure, target, and drug target till Feb 3, 2020. The search identified seven major targets (spike protein, envelop protein, membrane protein, protease, nucleocapsid protein, hemagglutinin esterase, and helicase) for which drug design can be considered. There are other 16 nonstructural proteins (NSPs), which can also be considered from the drug design perspective. The major structural proteins and NSPs may serve an important role from drug design perspectives. However, the occurrence of frequent recombination events is a major deterrent factor toward the development of CoV-specific vaccines/drugs. © 2020 Indian Journal of Pharmacology Published by Wolters Kluwer. Medknow.",Coronavirus; drug targets; Middle East respiratory syndrome; severe acute respiratory syndrome,"envelope protein; esterase; helicase; hemagglutinin; membrane protein; nonstructural protein; nucleocapsid protein; papain; proteinase; structural protein; unclassified drug; virus spike protein; viral protein; Coronavirinae; coronavirus disease 2019; Coronavirus infection; crystal structure; drug design; Middle East respiratory syndrome coronavirus; nonhuman; nuclear magnetic resonance spectroscopy; pH; protein domain; protein structure; Review; SARS coronavirus; systematic review; X ray crystallography; Betacoronavirus; chemistry; Coronavirus infection; drug design; drug effect; human; molecularly targeted therapy; virus pneumonia; Betacoronavirus; Coronavirus Infections; Drug Design; Humans; Middle East Respiratory Syndrome Coronavirus; Molecular Targeted Therapy; Pneumonia, Viral; SARS Virus; Viral Proteins","Yang, H., Bartlam, M., Rao, Z., Drug design targeting the main protease, the Achilles' heel of coronaviruses (2006) Curr Pharm des, 12, pp. 4573-4590; 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Chang, C.K., Jeyachandran, S., Hu, N.J., Liu, C.L., Lin, S.Y., Wang, Y.S., Structure-based virtual screening and experimental validation of the discovery of inhibitors targeted towards the human coronavirus nucleocapsid protein (2016) Mol Biosyst, 12, pp. 59-66; Roh, C., A facile inhibitor screening of SARS coronavirus N protein using nanoparticle-based RNA oligonucleotide (2012) Int J Nanomedicine, 7, pp. 2173-2179; Lo, Y.S., Lin, S.Y., Wang, S.M., Wang, C.T., Chiu, Y.L., Huang, T.H., Oligomerization of the carboxyl terminal domain of the human coronavirus 229E nucleocapsid protein (2013) FEBS Lett, 587, pp. 120-127; Cheung, Y.K., Cheng, S.C., Sin, F.W., Chan, K.T., Xie, Y., Induction of T-cell response by a DNA vaccine encoding a novel HLA-A 0201 severe acute respiratory syndrome coronavirus epitope (2007) Vaccine, 25, pp. 6070-6077; Zhao, J., Huang, Q., Wang, W., Zhang, Y., Lv, P., Gao, X.M., Identification and characterization of dominant helper T-cell epitopes in the nucleocapsid protein of severe acute respiratory syndrome coronavirus (2007) J Virol, 81, pp. 6079-6088; Lindner, H.A., Fotouhi-Ardakani, N., Lytvyn, V., Lachance, P., Sulea, T., Ménard, R., The papain-like protease from the severe acute respiratory syndrome coronavirus is a deubiquitinating enzyme (2005) J Virol, 79, pp. 15199-15208; Jo, S., Kim, S., Shin, D.H., Kim, M.S., Inhibition of SARS-CoV 3CL protease by flavonoids (2020) J Enzyme Inhib Med Chem, 35, pp. 145-151; Hu, T., Zhang, Y., Li, L., Wang, K., Chen, S., Chen, J., Two adjacent mutations on the dimer interface of SARS coronavirus 3C-like protease cause different conformational changes in crystal structure (2009) Virology, 388, pp. 324-334; Hsu, M.F., Kuo, C.J., Chang, K.T., Chang, H.C., Chou, C.C., Ko, T.P., Mechanism of the maturation process of SARS-CoV 3CL protease (2005) J Biol Chem, 280, pp. 31257-31266; Barretto, N., Jukneliene, D., Ratia, K., Chen, Z., Mesecar, A.D., Baker, S.C., The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity (2005) J Virol, 79, pp. 15189-15198; Turlington, M., Chun, A., Tomar, S., Eggler, A., Grum-Tokars, V., Jacobs, J., Discovery of N-(benzo[12, 3]triazol-1-yl)-N-(benzyl) acetamido) phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding (2013) Bioorg Med Chem Lett, 23, pp. 6172-6177; Jacobs, J., Grum-Tokars, V., Zhou, Y., Turlington, M., Saldanha, S.A., Chase, P., Discovery, synthesis, and structure-based optimization of a series of N-(tert-butyl)-2-(N-arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL protease (2013) J Med Chem, 56, pp. 534-546; Perera, K.D., Rathnayake, A.D., Liu, H., Pedersen, N.C., Groutas, W.C., Chang, K.O., Characterization of amino acid substitutions in feline coronavirus 3C-like protease from a cat with feline infectious peritonitis treated with a protease inhibitor (2019) Vet Microbiol, 237, p. 108398; Yang, H., Xie, W., Xue, X., Yang, K., Ma, J., Liang, W., Design of wide-spectrum inhibitors targeting coronavirus main proteases (2005) PLoS Biol, 3, p. e324; Liu, X., Wang, X.J., Potential Inhibitors for 2019-nCoV Coronavirus M Protease from Clinically Approved Medicines (2020) Bio Rxiv, , 2020.01.29.924100; Han, Y.S., Chang, G.G., Juo, C.G., Lee, H.J., Yeh, S.H., Hsu, J.T., Papain-like protease 2 (PLP2) from severe acute respiratory syndrome coronavirus (SARS-CoV): Expression, purification, characterization, and inhibition (2005) Biochemistry, 44, pp. 10349-10359; 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Simmons, G., Gosalia, D.N., Rennekamp, A.J., Reeves, J.D., Diamond, S.L., Bates, P., Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry (2005) Proc Natl Acad Sci USA, 102, pp. 11876-11881; Bertram, S., Glowacka, I., Müller, M.A., Lavender, H., Gnirss, K., Nehlmeier, I., Cleavage and activation of the severe acute respiratory syndrome coronavirus spike protein by human airway trypsin-like protease (2011) J Virol, 85, pp. 13363-13372; Stadler, K., Ha, H.R., Ciminale, V., Spirli, C., Saletti, G., Schiavon, M., Amiodarone alters late endosomes and inhibits SARS coronavirus infection at a post-endosomal level (2008) Am J Respir Cell Mol Biol, 39, pp. 142-149; (2020) Wuhan Seafood Market Pneumonia Virus Isolate Wuhan-Hu-1 Complete Genome, , http://www.ncbi.nlm.nih.gov/nuccore/NC_045512.2, [Last accessed on 2020 Feb 11]; The World Health Organization International Clinical Trials Registered Organization Registered Platform, , http://www.chictr.org.cn/abouten.aspx, Chinese Clinical Trial Register (ChiCTR), [Last accessed on 2020 Feb 24]","Medhi, B.; Department of Pharmacology, Postgraduate Institute of Medical Education and ResearchIndia; email: drbikashus@yahoo.com",,Wolters Kluwer Medknow Publications,2537613,,INJPD,32201449,English,Indian J. Pharmacol.,Review,Final,,Scopus,2-s2.0-85082092285,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Jo S., Kim S., Shin D.H., Kim M.-S.",57211403569;57193241841;15920079700;57203466599;,Inhibition of SARS-CoV 3CL protease by flavonoids,2020,Journal of Enzyme Inhibition and Medicinal Chemistry,35,1,,145,151,,3,10.1080/14756366.2019.1690480,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85074960169&doi=10.1080%2f14756366.2019.1690480&partnerID=40&md5=06a2e10c9b2ab658817e60d83b0c7cbe,"College of Pharmacy and Graduates School of Pharmaceutical Sciences, Ewha W. University, Seoul, South Korea","Jo, S., College of Pharmacy and Graduates School of Pharmaceutical Sciences, Ewha W. University, Seoul, South Korea; Kim, S., College of Pharmacy and Graduates School of Pharmaceutical Sciences, Ewha W. University, Seoul, South Korea; Shin, D.H., College of Pharmacy and Graduates School of Pharmaceutical Sciences, Ewha W. University, Seoul, South Korea; Kim, M.-S., College of Pharmacy and Graduates School of Pharmaceutical Sciences, Ewha W. University, Seoul, South Korea","There were severe panics caused by Severe Acute Respiratory Syndrome (SARS) and Middle-East Respiratory Syndrome-Coronavirus. Therefore, researches targeting these viruses have been required. Coronaviruses (CoVs) have been rising targets of some flavonoids. The antiviral activity of some flavonoids against CoVs is presumed directly caused by inhibiting 3C-like protease (3CLpro). Here, we applied a flavonoid library to systematically probe inhibitory compounds against SARS-CoV 3CLpro. Herbacetin, rhoifolin and pectolinarin were found to efficiently block the enzymatic activity of SARS-CoV 3CLpro. The interaction of the three flavonoids was confirmed using a tryptophan-based fluorescence method, too. An induced-fit docking analysis indicated that S1, S2 and S3′ sites are involved in binding with flavonoids. The comparison with previous studies showed that Triton X-100 played a critical role in objecting false positive or overestimated inhibitory activity of flavonoids. With the systematic analysis, the three flavonoids are suggested to be templates to design functionally improved inhibitors. © 2019, © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.",flavonoid; FRET; inhibitory compounds; SARS-CoV; SARS-CoV 3CLpro,"3 chymotrypsin like protease; amentoflavone; antivirus agent; cysteine proteinase; flavonoid; herbacetin; kaempferol; morin; pectolinarin; rhoifolin; triton x 100; tryptophan; unclassified drug; virus enzyme; 3C-like protease, SARS coronavirus; antivirus agent; cysteine proteinase; enzyme inhibitor; flavonoid; viral protein; antiviral activity; Article; controlled study; drug binding site; drug protein binding; enzyme activity; enzyme inhibition; fluorescence resonance energy transfer; molecular docking; nonhuman; priority journal; protein degradation; SARS coronavirus; severe acute respiratory syndrome; chemical structure; chemistry; dose response; drug effect; enzymology; human; isolation and purification; metabolism; structure activity relation; synthesis; Antiviral Agents; Cysteine Endopeptidases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Humans; Molecular Structure; SARS Virus; Structure-Activity Relationship; Viral Proteins","Lai, M.M., Cavanagh, D., The molecular biology of coronaviruses (1997) Adv Virus Res, 48, pp. 1-100; Mesel-Lemoine, M., Millet, J., Vidalain, P.-O., A human coronavirus responsible for the common cold massively kills dendritic cells but not monocytes (2012) J Virol, 86, pp. 7577-7587; de Wit, E., van Doremalen, N., Falzarano, D., Munster, V.J., SARS and MERS: recent insights into emerging coronaviruses (2016) Nat Rev Microbiol, 14, pp. 523-534; Drosten, C., Günther, S., Preiser, W., Identification of a novel coronavirus in patients with severe acute respiratory syndrome (2003) N Engl J Med, 348, pp. 1967-1976; Donnelly, C.A., Ghani, A.C., Leung, G.M., Epidemiological determinants of spread of causal agent of severe acute respiratory syndrome in Hong Kong (2003) Lancet, 361, pp. 1761-1766; Li, W., Shi, Z., Yu, M., Bats are natural reservoirs of SARS-like coronaviruses (2005) Science, 310, pp. 676-679; 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Wu, A., Wang, Y., Zeng, C., Prediction and biochemical analysis of putative cleavage sites of the 3C-like protease of Middle East respiratory syndrome coronavirus (2015) Virus Res, 208, pp. 56-65; Lin, H., Lan, J., Guan, M., Spectroscopic investigation of interaction between mangiferin and bovine serum albumin (2009) Spectrochim Acta A Mol Biomol Spectrosc, 73, pp. 936-941; Sherman, W., Day, T., Jacobson, M.P., Novel procedure for modeling ligand/receptor induced fit effects (2006) J Med Chem, 49, pp. 534-553; Jacobson, M.P., Pincus, D.L., Rapp, C.S., A hierarchical approach to all-atom protein loop prediction (2004) Proteins, 55, pp. 351-367; Friesner, R.A., Murphy, R.B., Repasky, M.P., Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes (2006) J Med Chem, 49, pp. 6177-6196; Pohjala, L., Tammela, P., Aggregating behavior of phenolic compounds–a source of false bioassay results? (2012) Molecules (Basel, Switzerland), 17, pp. 10774-10790; Burak, M., Imen, Y., Flavonoids and their antioxidant properties (1999) Turkiye Klin Tip Bil Derg, 19, pp. 296-304; Ovando, C., Hernandez, D., Hernandez, E., Chemical studies of anthocyanins: a review (2009) Food Chem, 113, pp. 859-871; Lee, Y., Yuk, D., Lee, J., Epigallocatechin-3-gallate prevents lipopolysaccharide-induced elevation of β-amyloid generation and memory deficiency (2009) Brain Res, 1250, pp. 164-174; Ryu, Y.B., Jeong, H.J., Kim, J.H., Biflavonoids from Torreya nucifera displaying SARS-CoV 3CL(pro) inhibition (2010) Bioorg Med Chem, 18, pp. 7940-11947; Nguyen, T.T., Woo, H.J., Kang, H.K., Flavonoid-mediated inhibition of SARS coronavirus 3C-like protease expressed in Pichia pastoris (2012) Biotechnol Lett, 34, pp. 831-838; Schwarz, S., Sauter, D., Wang, K., Kaempferol derivatives as antiviral drugs against the 3a channel protein of coronavirus (2014) Planta Med, 80, pp. 177-182","Shin, D.H.; Department of Pharmacy, Ewha W. UniversitySouth Korea; email: dhshin55@ewha.ac.kr",,Taylor and Francis Ltd,14756366,,JEIMA,31724441,English,J. Enzyme Inhib. Med. Chem.,Article,Final,Open Access,Scopus,2-s2.0-85074960169,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Salamatbakhsh M., Mobaraki K., Ahmadzadeh J.",57211228027;55853618500;36573331500;,Syndromic surveillance system for MERS-CoV as new early warning and identification approach,2020,Risk Management and Healthcare Policy,13,,,93,95,,,10.2147/RMHP.S239984,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079435336&doi=10.2147%2fRMHP.S239984&partnerID=40&md5=ee13d8c00b9733544e8b75f44aed6412,"Critical Care Nursing, Urmia University of Medical Sciences, Urmia, Iran; Epidemiologist in Social Determinants of Health Research Center, Urmia University of Medical Sciences, Urmia, Iran","Salamatbakhsh, M., Critical Care Nursing, Urmia University of Medical Sciences, Urmia, Iran; Mobaraki, K., Epidemiologist in Social Determinants of Health Research Center, Urmia University of Medical Sciences, Urmia, Iran; Ahmadzadeh, J., Epidemiologist in Social Determinants of Health Research Center, Urmia University of Medical Sciences, Urmia, Iran",This commentary presents a novel outlook for public health authorities in the affected countries to detect and respond quickly to the emerging public health threats such as Middle East respiratory syndrome coronavirus (MERS-CoV). Implementing an innovative electronic surveillance system called syndromic surveillance system is essential for global health security. © 2020 Salamatbakhsh et al.,Middle East respiratory syndrome; Syndromic surveillance system; Traditional surveillance system,bioterrorism; disease severity; disease surveillance; epidemic; global health; incidence; Middle East respiratory syndrome coronavirus; morbidity; Note; prevalence; public health service; syndromic surveillance system,"Mobaraki, K., Ahmadzadeh, J., Current epidemiological status of Middle East respiratory syndrome coronavirus in the world from 1.1. 2017 to 17.1. 2018: A cross-sectional study (2019) BMC Infect Dis, 19 (1); Salamatbakhsh, M., Mobaraki, K., Sadeghimohammadi, S., Ahmadzadeh, J., The global burden of premature mortality due to the Middle East respiratory syndrome (MERS) using standard expected years of life lost, 2012 to 2019 (2019) BMC Public Health, 19 (1), p. 1523; Ahmadzadeh, J., Mobaraki, K., Mousavi, S.J., Aghazadeh-Attari, J., Mirza-Aghazadeh-Attari, M., Mohebbi, I., The risk factors associated with MERS-CoV patient fatality: A global survey (2019) Diagn Microbiol Infect Dis; Middle East Respiratory Syndrome Coronavirus (Mers-Cov), , http://www.who.int/emergencies/mers-cov/en/, Available from; Surveillance, G.L., (2008) Epidemiology, pp. 42-45. , 4th ed. Saunders: Philadelphia; van Den Wijngaard, C.C., van Asten, L., van Pelt, W., Syndromic surveillance for local outbreaks of lower-respiratory infections: Would it work? (2010) Plos One, 5 (4); Henning, K.J., What is syndromic surveillance (2004) Morb Mortal Wkly Rep, 53, pp. 7-11. , Supplement; Aghazadeh-Attari, J., Mohebbi, I., Mansorian, B., Epidemiological factors and worldwide pattern of Middle East respiratory syndrome coronavirus from 2013 to 2016 (2018) Int J Gen Med, 11, p. 121; Ahmadzadeh, J., Mobaraki, K., Epidemiological status of the Middle East respiratory syndrome coronavirus in 2019: An update from January 1 to March 31, 2019 (2019) Int J Gen Med., 12, p. 305; Mobaraki, K., Ahmadzadeh, J., An update to Middle East respiratory syndrome coronavirus and risk of a pandemic in 2019 (2019) Clin Microbiol Infect Dis, 50 (8), p. 421; Mobaraki, K., Salamatbakhsh, M., Ahmadzadeh, J., Standard expected years of life lost as a neglected index for calculating the burden of premature mortality due to Middle East respiratory syndrome (2019) Health Secur, 17 (5), pp. 407-409","Ahmadzadeh, J.; Social Determinants of Health Research Center, Urmia University of Medical Sciences, Resalat Street, Iran; email: ahmadzadeh.j@umsu.ac.ir",,Dove Medical Press Ltd,11791594,,,,English,Risk Manage. Healthc. Policy,Note,Final,Open Access,Scopus,2-s2.0-85079435336,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Alanazi K.H., Abedi G.R., Midgley C.M., Alkhamis A., Alsaqer T., Almoaddi A., Algwizani A., Ghazal S.S., Assiri A.M., Jokhdar H., Gerber S.I., Alabdely H., Watson J.T.",57205250746;55887217800;56372310100;57207929673;57204805473;57212563414;57192893697;6602583744;36607531400;6507147807;56656063700;15762182700;55374101200;,"Diabetes mellitus, hypertension, and death among 32 patients with MERS-CoV infection, Saudi Arabia",2020,Emerging Infectious Diseases,26,1,,166,168,,,10.3201/eid2601.190952,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077046285&doi=10.3201%2feid2601.190952&partnerID=40&md5=98ccc888d1f31b9860e70f610be70128,"Ministry of Health, Riyadh, Saudi Arabia; Centers for Disease Control and Prevention, 1600 Clifton RD NE, Mailstop A34, Atlanta, GA 30329-4027, United States","Alanazi, K.H., Ministry of Health, Riyadh, Saudi Arabia; Abedi, G.R., Centers for Disease Control and Prevention, 1600 Clifton RD NE, Mailstop A34, Atlanta, GA 30329-4027, United States; Midgley, C.M., Centers for Disease Control and Prevention, 1600 Clifton RD NE, Mailstop A34, Atlanta, GA 30329-4027, United States; Alkhamis, A., Ministry of Health, Riyadh, Saudi Arabia; Alsaqer, T., Ministry of Health, Riyadh, Saudi Arabia; Almoaddi, A., Ministry of Health, Riyadh, Saudi Arabia; Algwizani, A., Ministry of Health, Riyadh, Saudi Arabia; Ghazal, S.S., Ministry of Health, Riyadh, Saudi Arabia; Assiri, A.M., Ministry of Health, Riyadh, Saudi Arabia; Jokhdar, H., Ministry of Health, Riyadh, Saudi Arabia; Gerber, S.I., Centers for Disease Control and Prevention, 1600 Clifton RD NE, Mailstop A34, Atlanta, GA 30329-4027, United States; Alabdely, H., Ministry of Health, Riyadh, Saudi Arabia; Watson, J.T., Centers for Disease Control and Prevention, 1600 Clifton RD NE, Mailstop A34, Atlanta, GA 30329-4027, United States","Diabetes mellitus and hypertension are recognized risk factors for severe clinical outcomes, including death, associated with Middle East respiratory syndrome coronavirus infection. Among 32 virus-infected patients in Saudi Arabia, severity of illness and frequency of death corresponded closely with presence of multiple and more severe underlying conditions. © 2020 Centers for Disease Control and Prevention (CDC). All rights reserved.",,adult; aged; Article; asthma; cardiovascular disease; chronic kidney failure; chronic lung disease; chronic organ damage; clinical article; clinical outcome; coronary artery disease; diabetes mellitus; disease severity; epilepsy; female; hospitalization; human; hyperglycemia; hypertension; interactive ventilatory support; male; middle aged; Middle East respiratory syndrome coronavirus; mortality rate; nonhuman; oxygen supply; risk factor; Saudi Arabia; uterus cancer,"Regional Office for the Eastern Mediterranean, , http://www.emro.who.int/pandemic-epidemic-diseases/mers-cov/mers-situation-update-october-2018.html, World Health Organization, MERS situation update; October 2018 [cited 2019 Oct 30]; Assiri, A., Al-Tawfiq, J.A., Al-Rabeeah, A.A., Al-Rabiah, F.A., Al-Hajjar, S., Al-Barrak, A., Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: A descriptive study (2013) Lancet Infect Dis, 13, pp. 752-761. , http://doi.org/10.1016/S1473-3099(13).70204-4; Alqahtani, F.Y., Aleanizy, F.S., Ali El Hadi Mohamed, R., Alanazi, M.S., Mohamed, N., Alrasheed, M.M., Prevalence of comorbidities in cases of Middle East respiratory syndrome coronavirus: A retrospective study (2018) Epidemiol Infect, pp. 1-5. , Nov 5; Al-Abdely, H.M., Midgley, C.M., Alkhamis, A.M., Abedi, G.R., Lu, X., Binder, A.M., Middle East respiratory syndrome coronavirus infection dynamics and antibody responses among clinically diverse patients Saudi Arabia (2019) Emerg Infect Dis, 25, pp. 753-766. , http://doi.org/10.3201/eid2504.181595; Alraddadi, B.M., Watson, J.T., Almarashi, A., Abedi, G.R., Turkistani, A., Sadran, M., Risk factors for primary Middle East respiratory syndrome coronavirus illness in humans (2016) Saudi Arabia 2014. Emerg Infect Dis, 22, pp. 49-55. , http://doi.org/10.3201/eid2201.151340","Abedi, G.R.; Centers for Disease Control and Prevention, 1600 Clifton RD NE, Mailstop A34, United States; email: gabedi@cdc.gov",,Centers for Disease Control and Prevention (CDC),10806040,,EIDIF,31855530,English,Emerg. Infect. Dis.,Article,Final,Open Access,Scopus,2-s2.0-85077046285,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Baig A.M., Khaleeq A., Ali U., Syeda H.",56008810600;57209222822;57216038611;57216040416;,"Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms",2020,ACS Chemical Neuroscience,,,,,,,,10.1021/acschemneuro.0c00122,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082526544&doi=10.1021%2facschemneuro.0c00122&partnerID=40&md5=2a43d767a2305dc559b625491f138420,"Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, 74800, Pakistan; Medical College, Aga Khan University, Karachi, 74800, Pakistan; Department of Biosciences, Mohammad Ali Jinnah University, Karachi, 75400, Pakistan","Baig, A.M., Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, 74800, Pakistan; Khaleeq, A., Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, 74800, Pakistan; Ali, U., Medical College, Aga Khan University, Karachi, 74800, Pakistan; Syeda, H., Department of Biosciences, Mohammad Ali Jinnah University, Karachi, 75400, Pakistan","The recent outbreak of coronavirus infectious disease 2019 (COVID-19) has gripped the world with apprehension and has evoked a scare of epic proportion regarding its potential to spread and infect humans worldwide. As we are in the midst of an ongoing pandemic of COVID-19, scientists are struggling to understand how it resembles and differs from the severe acute respiratory syndrome coronavirus (SARS-CoV) at the genomic and transcriptomic level. In a short time following the outbreak, it has been shown that, similar to SARS-CoV, COVID-19 virus exploits the angiotensin-converting enzyme 2 (ACE2) receptor to gain entry inside the cells. This finding raises the curiosity of investigating the expression of ACE2 in neurological tissue and determining the possible contribution of neurological tissue damage to the morbidity and mortality caused by COIVD-19. Here, we investigate the density of the expression levels of ACE2 in the CNS, the host-virus interaction and relate it to the pathogenesis and complications seen in the recent cases resulting from the COVID-19 outbreak. Also, we debate the need for a model for staging COVID-19 based on neurological tissue involvement. Copyright © 2020 American Chemical Society.",ACE2 tissue distribution; Coronavirus; COVID-19; Host-virus interaction; SARS-CoV-2; Spike protein,,"Wuhan seafood market pneumonia virus isolate Wuhan-Hu-1, complete genome Nucleotide, , https://www.ncbi.nlm.nih.gov/nuccore/1798174254, National Center for Biotechnology Information (NCBI), National Library of Medicine (US), National Center for Biotechnology Information, Bethesda, MD, (accessed on 2020-02-28); Palasca, O., Santos, A., Stolte, C., Gorodkin, J., Jensen, L.J., TISSUES 2.0: an integrative web resource on mammalian tissue expression (2018) Database, 2018, p. bay003; Netland, J., Meyerholz, D.K., Moore, S., Cassell, M., Perlman, S., Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2 (2008) J. Virol., 82 (15), pp. 7264-75; Mao, L., Wang, M., Chen, S., He, Q., Chang, J., Hong, C., Zhou, Y., Hu, B., Neurological Manifestations of Hospitalized Patients with COVID-19 in Wuhan, China: a retrospective case series study medRxiv, , 2020.02.22.20026500 (accessed on 2020-02-28); Li, Y.C., Bai, W.Z., Hashikawa, T., The neuroinvasive potential of SARS-CoV2 may be at least partially responsible for the respiratory failure of COVID-19 patients (2020) J. Med. Virol.; Wrapp, D., Wang, N., Corbett, K.S., Goldsmith, J.A., Hsieh, C.L., Abiona, O., Graham, B.S., McLellan, J.S., Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation (2020) Science, p. eabb2507; Baig, A.M., Primary Amoebic Meningoencephalitis: Neurochemotaxis and Neurotropic Preferences of Naegleria fowleri (2016) ACS Chem. Neurosci., 7 (8), pp. 1026-9","Baig, A.M.; Department of Biological and Biomedical Sciences, Aga Khan UniversityPakistan; email: abdul.mannan@aku.edu",,American Chemical Society,19487193,,ACNCD,32167747,English,ACS Chem. Neurosci.,Review,Article in Press,Open Access,Scopus,2-s2.0-85082526544,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Krichel B., Falke S., Hilgenfeld R., Redecke L., Uetrecht C.",57189001904;57215865059;7006843618;15823096800;24081661900;,Processing of the SARS-CoV pp1a/ab nsp7-10 region,2020,Biochemical Journal,477,5,,1009,1019,,,10.1042/BCJ20200029,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082146457&doi=10.1042%2fBCJ20200029&partnerID=40&md5=bcf3058b224a42de641250fc23470b04,"Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Martinistraße 52, Hamburg, 20251, Germany; University of Hamburg, Institut für Biochemie und Molekularbiologie, Martin-Luther-King-Platz 6, Hamburg, 20146, Germany; University of Lübeck, Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, Ratzeburger Allee 160, Lübeck, 23562, Germany; German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems Site, University of Lübeck, Ratzeburger Allee 160, Lübeck, 23562, Germany; Deutsches Elektronen Synchrotron (DESY), Notkestraße 85, Hamburg, 22607, Germany; European XFEL GmbH, Holzkoppel 4, Schenefeld, 22869, Germany","Krichel, B., Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Martinistraße 52, Hamburg, 20251, Germany; Falke, S., University of Hamburg, Institut für Biochemie und Molekularbiologie, Martin-Luther-King-Platz 6, Hamburg, 20146, Germany; Hilgenfeld, R., University of Lübeck, Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, Ratzeburger Allee 160, Lübeck, 23562, Germany, German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel-Riems Site, University of Lübeck, Ratzeburger Allee 160, Lübeck, 23562, Germany; Redecke, L., University of Lübeck, Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, Ratzeburger Allee 160, Lübeck, 23562, Germany, Deutsches Elektronen Synchrotron (DESY), Notkestraße 85, Hamburg, 22607, Germany; Uetrecht, C., Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Martinistraße 52, Hamburg, 20251, Germany, European XFEL GmbH, Holzkoppel 4, Schenefeld, 22869, Germany","Severe acute respiratory syndrome coronavirus is the causative agent of a respiratory disease with a high case fatality rate. During the formation of the coronaviral replication/ transcription complex, essential steps include processing of the conserved polyprotein nsp7-10 region by the main protease Mpro and subsequent complex formation of the released nsp's. Here, we analyzed processing of the coronavirus nsp7-10 region using native mass spectrometry showing consumption of substrate, rise and fall of intermediate products and complexation. Importantly, there is a clear order of cleavage efficiencies, which is influenced by the polyprotein tertiary structure. Furthermore, the predominant product is an nsp7+8(2: 2) hetero-tetramer with nsp8 scaffold. In conclusion, native MS, opposed to other methods, can expose the processing dynamics of viral polyproteins and the landscape of protein interactions in one set of experiments. Thereby, new insights into protein interactions, essential for generation of viral progeny, were provided, with relevance for development of antivirals. © 2020 The Author(s). This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY).",,,"Drosten, C., Günther, S., Preiser, W., van der Werf, S., Brodt, H.R., Becker, S., Identification of a novel coronavirus in patients with severe acute respiratory syndrome (2003) N. Engl. J. 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Commun., 329, pp. 934-940. , https://doi.org/10.1016/j.bbrc.2005.02.061; Chuck, C.-P., Chong, L.-T., Chen, C., Chow, H.-F., Wan, D.C.-C., Wong, K.-B., Profiling of substrate specificity of SARS-CoV 3CLpro (2010) PLoS One, 5. , https://doi.org/10.1371/journal.pone.0013197; Ponnusamy, R., Moll, R., Weimar, T., Mesters, J.R., Hilgenfeld, R., Variable oligomerization modes in coronavirus non-structural protein 9 (2008) J. Mol. Biol., 383, pp. 1081-1096. , https://doi.org/10.1016/j.jmb.2008.07.071; Liu, F., Rijkers, D.T.S., Post, H., Heck, A.J.R., Proteome-wide profiling of protein assemblies by cross-linking mass spectrometry (2015) Nat. Methods, 12, pp. 1179-1184. , https://doi.org/10.1038/nmeth.3603; Specht, H., Emmott, E., Petelski, A., Huffman, R.G., Perlman, D.H., Serra, M., Single-cell mass-spectrometry quantifies the emergence of macrophage heterogeneity (2019) bioRxiv, p. 665307. , https://doi.org/10.1101/665307","Uetrecht, C.; Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Martinistraße 52, Germany; email: charlotte.uetrecht@xfel.eu",,Portland Press Ltd,2646021,,BIJOA,32083638,English,Biochem. J.,Article,Final,Open Access,Scopus,2-s2.0-85082146457,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Letko M., Marzi A., Munster V.",55240038400;8832647400;9332531900;,Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses,2020,Nature Microbiology,5,4,,562,569,,3,10.1038/s41564-020-0688-y,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079767277&doi=10.1038%2fs41564-020-0688-y&partnerID=40&md5=02b475d9ec4e8dc67a12e3cea35a056e,"Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, United States","Letko, M., Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, United States; Marzi, A., Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, United States; Munster, V., Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, United States","Over the past 20 years, several coronaviruses have crossed the species barrier into humans, causing outbreaks of severe, and often fatal, respiratory illness. Since SARS-CoV was first identified in animal markets, global viromics projects have discovered thousands of coronavirus sequences in diverse animals and geographic regions. Unfortunately, there are few tools available to functionally test these viruses for their ability to infect humans, which has severely hampered efforts to predict the next zoonotic viral outbreak. Here, we developed an approach to rapidly screen lineage B betacoronaviruses, such as SARS-CoV and the recent SARS-CoV-2, for receptor usage and their ability to infect cell types from different species. We show that host protease processing during viral entry is a significant barrier for several lineage B viruses and that bypassing this barrier allows several lineage B viruses to enter human cells through an unknown receptor. We also demonstrate how different lineage B viruses can recombine to gain entry into human cells, and confirm that human ACE2 is the receptor for the recently emerging SARS-CoV-2. © 2020, The Author(s), under exclusive licence to Springer Nature Limited.",,,"Wang, M., SARS-CoV infection in a restaurant from palm civet (2005) Emerg. Infect. Dis., 11, pp. 1860-1865; Kuiken, T., Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome (2003) Lancet, 362, pp. 263-270; Li, W., Bats are natural reservoirs of SARS-like coronaviruses (2005) Science, 310, pp. 676-679; Ge, X.Y., Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor (2013) Nature, 503, pp. 535-538; Hu, B., Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus (2017) PLoS Pathog., 13; Lau, S.K., Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats (2005) Proc. 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Virol., 66, pp. 6117-6124; Graham, R.L., Baric, R.S., Recombination, reservoirs, and the modular spike: mechanisms of coronavirus cross-species transmission (2010) J. Virol., 84, pp. 3134-3146; Seifert, S.N., Rousettus aegyptiacus bats do not support productive Nipah virus replication (2019) J. Infect. Dis, , https://doi.org/10.1093/infdis/jiz429; Takada, A., A system for functional analysis of Ebola virus glycoprotein (1997) Proc. Natl Acad. Sci. USA, 94, pp. 14764-14769","Letko, M.; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of HealthUnited States; email: michael.letko@wsu.edu",,Nature Research,20585276,,,32094589,English,Nat. Microbiol.,Article,Final,Open Access,Scopus,2-s2.0-85079767277,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Meyerholz D.K., Beck A.P.",6602303240;55252272100;,Histopathologic evaluation and scoring of viral lung infection,2020,Methods in Molecular Biology,2099,,,205,220,,,10.1007/978-1-0716-0211-9_16,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077323325&doi=10.1007%2f978-1-0716-0211-9_16&partnerID=40&md5=f18e12451effebdb490dc5e675d8bbf7,"Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA, United States; Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, United States","Meyerholz, D.K., Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, IA, United States; Beck, A.P., Department of Pathology, Albert Einstein College of Medicine, Bronx, NY, United States","Emergent coronaviruses such as MERS-CoV and SARS-CoV can cause significant morbidity and mortality in infected individuals. Lung infection is a common clinical feature and contributes to disease severity as well as viral transmission. Animal models are often required to study viral infections and therapies, especially during an initial outbreak. Histopathology studies allow for identification of lesions and affected cell types to better understand viral pathogenesis and clarify effective therapies. Use of immunostaining allows detection of presumed viral receptors and viral tropism for cells can be evaluated to correlate with lesions. In the lung, lesions and immunostaining can be qualitatively described to define the cell types, microanatomic location, and type of changes seen. These features are important and necessary, but this approach can have limitations when comparing treatment groups. Semiquantitative and quantitative tissue scores are more rigorous as these provide the ability to statistically compare groups and increase the reproducibility and rigor of the study. 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Meyerholz, D.K., Beck, A.P., Goeken, J.A., Leidin-Ger, M.R., Ofori-Amanfo, G.K., Brown, H.C., Busi-Nga, T.R., Flaherty, H.A., Glycogen depletion can increase the specificity of mucin detection in airway tissues (2018) BMC Res Notes, 11 (1). , https://doi.org/10.1186/s13104-018-3855-y; Vergara-Alert, J., Vidal, E., Bensaid, A., Segales, J., Searching for animal models and potential target species for emerging pathogens: Experience gained from Middle East respiratory syndrome (MERS) coronavirus (2017) One Health, 3, pp. 34-40. , https://doi.org/10.1016/j.onehlt.2017.03.001; Haagmans, B.L., van den Brand, J.M., Provacia, L.B., Raj, V.S., Stittelaar, K.J., Getu, S., de Waal, L., Osterhaus, A.D., Asymptomatic Middle East respiratory syndrome coronavirus infection in rabbits (2015) J Virol, 89 (11), pp. 6131-6135. , https://doi.org/10.1128/JVI.00661-15; Vergara-Alert, J., van den Brand, J.M., Widagdo, W., Munoz, M.T., Raj, S., Schipper, D., Solanes, D., Segales, J., Livestock susceptibility to infection with Middle East respiratory syndrome coronavirus (2017) Emerg Infect Dis, 23 (2), pp. 232-240. , https://doi.org/10.3201/eid2302.161239; Widagdo, W., Raj, V.S., Schipper, D., Kolijn, K., van Leenders, G., Bosch, B.J., Bensaid, A., Haagmans, B.L., Differential expression of the Middle East respiratory syndrome coronavirus receptor in the upper respiratory tracts of humans and dromedary camels (2016) J Virol, 90 (9), pp. 4838-4842. , https://doi.org/10.1128/JVI.02994-15; Janardhan, K.S., Jensen, H., Clayton, N.P., Herbert, R.A., Immunohistochemistry in investigative and toxicologic pathology (2018) Toxicol Pathol, 46 (5), pp. 488-510. , https://doi.org/10.1177/0192623318776907; Kim, S.W., Roh, J., Park, C.S., Immunohistochemistry for pathologists: Protocols, pitfalls, and tips (2016) J Pathol Transl Med, 50 (6), pp. 411-418. , https://doi.org/10.4132/jptm.2016.08.08; Ramos-Vara, J.A., Miller, M.A., When tissue antigens and antibodies get along: Revisiting the technical aspects of immunohistochemistry-the red, brown, and blue technique (2014) Vet Pathol, 51 (1), pp. 42-87. , https://doi.org/10.1177/0300985813505879; Ward, J.M., Rehg, J.E., Rodent immunohistochemistry: Pitfalls and troubleshooting (2014) Vet Pathol, 51 (1), pp. 88-101. , https://doi.org/10.1177/0300985813503571; Aeffner, F., Adissu, H.A., Boyle, M.C., Cardiff, R.D., Hagendorn, E., Hoenerhoff, M.J., Klopfleisch, R., Wilson, K., Digital microscopy, image analysis, and virtual slide repository (2018) ILAR J, 59, pp. 66-79. , https://doi.org/10.1093/ilar/ily007; Barisoni, L., Gimpel, C., Kain, R., Laurinavicius, A., Bueno, G., Zeng, C., Liu, Z., Hewitt, S.M., Digital pathology imaging as a novel platform for standardization and globalization of quantitative nephropathology (2017) Clin Kidney J, 10 (2), pp. 176-187. , https://doi.org/10.1093/ckj/sfw129; Colling, R., Pitman, H., Oien, K., Rajpoot, N., Macklin, P., Snead, D., Sackville, T., Verrill, C., Artificial intelligence in digital pathology: A roadmap to routine use in clinical practice (2019) J Pathol, , https://doi.org/10.1002/path.5310; Niazi, M.K.K., Parwani, A.V., Gurcan, M.N., Digital pathology and artificial intelligence (2019) Lancet Oncol, 20 (5), pp. e253-e261. , https://doi.org/10.1016/S1470-2045(19)30154-8","Meyerholz, D.K.; Department of Pathology, University of Iowa Carver College of MedicineUnited States; email: david-meyerholz@uiowa.edu",,Humana Press Inc.,10643745,,,31883098,English,Methods Mol. Biol.,Book Chapter,Final,Open Access,Scopus,2-s2.0-85077323325,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhang W., Du R.-H., Li B., Zheng X.-S., Yang X.-L., Hu B., Wang Y.-Y., Xiao G.-F., Yan B., Shi Z.-L., Zhou P.",56151953000;57214933480;57077269800;57198448529;35811468700;55908560200;57214940355;8237740300;57204351774;7403733955;56996599500;,Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes,2020,Emerging Microbes and Infections,9,1,,386,389,,10,10.1080/22221751.2020.1729071,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079546081&doi=10.1080%2f22221751.2020.1729071&partnerID=40&md5=fb96400eaa436d2b08553018ba65995a,"CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Wuhan Pulmonary Hospital, Wuhan, China","Zhang, W., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Du, R.-H., Wuhan Pulmonary Hospital, Wuhan, China; Li, B., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Zheng, X.-S., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Yang, X.-L., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Hu, B., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Wang, Y.-Y., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Xiao, G.-F., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Yan, B., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Shi, Z.-L., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Zhou, P., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China","In December 2019, a novel coronavirus (2019-nCoV) caused an outbreak in Wuhan, China, and soon spread to other parts of the world. It was believed that 2019-nCoV was transmitted through respiratory tract and then induced pneumonia, thus molecular diagnosis based on oral swabs was used for confirmation of this disease. Likewise, patient will be released upon two times of negative detection from oral swabs. However, many coronaviruses can also be transmitted through oral–fecal route by infecting intestines. Whether 2019-nCoV infected patients also carry virus in other organs like intestine need to be tested. We conducted investigation on patients in a local hospital who were infected with this virus. We found the presence of 2019-nCoV in anal swabs and blood as well, and more anal swab positives than oral swab positives in a later stage of infection, suggesting shedding and thereby transmitted through oral–fecal route. We also showed serology test can improve detection positive rate thus should be used in future epidemiology. Our report provides a cautionary warning that 2019-nCoV may be shed through multiple routes. © 2020, © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd.",2019-nCoV; epidemiology; intestine; swabs; Wuhan pneumonia,"nucleotide; viral protein; COVID-19; severe acute respiratory syndrome coronavirus 2; 2019 novel coronavirus; antibody titer; Article; clinical article; controlled study; Coronavirinae; Coronavirus infection; feces analysis; hospital admission; human; molecular diagnosis; nonhuman; priority journal; real time polymerase chain reaction; serology; viremia; virus shedding; virus transmission; Betacoronavirus; China; Coronavirus infection; feces; isolation and purification; virology; virus pneumonia; Betacoronavirus; China; Coronavirus Infections; Feces; Humans; Pneumonia, Viral; Virus Shedding","WHO Press Statement Related to the Novel Coronavirus Situation, 2019; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, , https://doi.org/10.1016/S0140-6736(20)30183-5; Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, , https://doi.org/10.1056/NEJMoa2001017; Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med, , https://doi.org/10.1056/NEJMoa2001316; Zhou, P., Yang, X.L., Wang, X.G., Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin (2020) BioRxiv; Wang, N., Li, S.Y., Yang, X.L., Serological evidence of bat SARS-related coronavirus infection in humans, China (2018) Virol Sin, 33, pp. 104-107; Shi, X., Gong, E., Gao, D., Severe acute respiratory syndrome associated coronavirus is detected in intestinal tissues of fatal cases (2005) Am J Gastroenterol., 100 (1), pp. 169-176; Ding, Y., He, L., Zhang, Q., Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways (2004) J Pathol., 203 (2), pp. 622-630; Zhou, J., Li, C., Zhao, G., Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus (2017) Sci Adv, 3 (11), p. eaao4966. , https://doi.org/10.1126/sciadv.aao4966","Shi, Z.-L.; CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of SciencesChina; email: zlshi@wh.iov.cn",,Taylor and Francis Ltd.,22221751,,,32065057,English,Emerg. Microbes Infect.,Article,Final,Open Access,Scopus,2-s2.0-85079546081,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Letko M., Munster V.",55240038400;9332531900;,Studying evolutionary adaptation of MERS-CoV,2020,Methods in Molecular Biology,2099,,,3,8,,,10.1007/978-1-0716-0211-9_1,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077336585&doi=10.1007%2f978-1-0716-0211-9_1&partnerID=40&md5=9cb23a611bbc49eebc65465defa74124,"Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, National Institutes of Health, Hamilton, MT, United States","Letko, M., Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, National Institutes of Health, Hamilton, MT, United States; Munster, V., Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, National Institutes of Health, Hamilton, MT, United States","Forced viral adaptation is a powerful technique employed to study the ways viruses may overcome various selective pressures that reduce viral replication. Here, we describe methods for in vitro serial passaging of Middle East respiratory syndrome coronavirus (MERS-CoV) to select for mutations which increase replication on semi-permissive cell lines as described in Letko et al., Cell Rep 24, 1730–1737, 2018. © Springer Science+Business Media, LLC, part of Springer Nature 2020.",Cell culture; Experimental evolution; Forced adaptation; Host restriction; MERS-CoV; Semi-permissive cell line; Species barrier,controlled study; evolutionary adaptation; human cell; in vitro study; Middle East respiratory syndrome coronavirus; nonhuman; article,"Andino, R., Domingo, E., Viral quasispecies (2015) Virology, 479-480, pp. 46-51; Domingo, E., Sheldon, J., Perales, C., Viral quasispecies evolution (2012) Microbiol Mol Biol Rev, 76 (2), pp. 159-216; Lauring, A.S., Andino, R., Quasispecies theory and the behavior of RNA viruses (2010) Plos Pathog, 6 (7); Bazmi, H.Z., In vitro selection of mutations in the human immunodeficiency virus type 1 reverse transcriptase that decrease susceptibility to (‒)-beta-D-dioxolane-guano-sine and suppress resistance to 3'-azido-3-'-deoxythymidine (2000) Antimicrob Agents Chemother, 44 (7), pp. 1783-1788; Sato, A., In vitro selection of mutations in human immunodeficiency virus type 1 reverse transcriptase that confer resistance to capravirine, a novel nonnucleoside reverse transcriptase inhibitor (2006) Antivir Res, 70 (2), pp. 66-74; McKimm-Breschkin, J.L., In vitro passaging of a pandemic H1N1/09 virus selects for viruses with neuraminidase mutations conferring high-level resistance to oselta-mivir and peramivir, but not to zanamivir (2012) J Antimicrob Chemother, 67 (8), pp. 1874-1883; Shibata, J., Impact of V2 mutations on escape from a potent neutralizing anti-V3 monoclonal antibody during in vitro selection of a primary human immunodeficiency virus type 1 isolate (2007) J Virol, 81 (8), pp. 3757-3768; Chai, N., Two escape mechanisms of influenza avirus to a broadly neutralizing stalk-binding antibody (2016) Plos Pathog, 12 (6); Letko, M., Identification of the HIV-1 Vif and human APOBEC3G protein Interface (2015) Cell Rep, 13 (9), pp. 1789-1799; Ooms, M., HIV-1 Vif adaptation to human APOBEC3H haplotypes (2013) Cell Host Microbe, 14 (4), pp. 411-421; Ooms, M., Letko, M., Simon, V., The structural Interface between HIV-1 Vif and human APOBEC3H (2017) J Virol, 91 (5), p. e02289; Letko, M., Adaptive evolution of MERS-CoV to species variation in DPP4 (2018) Cell Rep, 24 (7), pp. 1730-1737; Baric, R.S., Persistent infection promotes cross-species transmissibility of mouse hepatitis virus (1999) J Virol, 73 (1), pp. 638-649; McRoy, W.C., Baric, R.S., Amino acid substitutions in the S2 subunit of mouse hepatitis virus variant V51 encode determinants of host range expansion (2008) J Virol, 82 (3), pp. 1414-1424; Khasawneh, A.I., Forced virus evolution reveals functional crosstalk between the disulfide bonded region and membrane proximal ectodomain region of HIV-1 gp41 (2013) Retro-Virology, 10, p. 44; Das, A.T., Optimization of the doxycycline-dependent simian immunodeficiency virus through in vitro evolution (2008) Retro-Virology, 5, p. 44; Westerhout, E.M., HIV-1 can escape from RNA interference by evolving an alternative structure in its RNA genome (2005) Nucleic Acids Res, 33 (2), pp. 796-804; van Doremalen, N., Host species restriction of Middle East respiratory syndrome coronavirus through its receptor, dipeptidyl peptidase 4 (2014) J Virol, 88 (16), pp. 9220-9232","Letko, M.; Laboratory of Virology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, Rocky Mountain Laboratories, National Institutes of HealthUnited States; email: michael.letko@nih.gov",,Humana Press Inc.,10643745,,,31883083,English,Methods Mol. Biol.,Book Chapter,Final,Open Access,Scopus,2-s2.0-85077336585,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Liu K., Chen Y., Lin R., Han K.",57215695573;57215693063;57215699696;57216038084;,Clinical features of COVID-19 in elderly patients: A comparison with young and middle-aged patients,2020,Journal of Infection,,,,,,,,10.1016/j.jinf.2020.03.005,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082527843&doi=10.1016%2fj.jinf.2020.03.005&partnerID=40&md5=9e39a1dde77ada85e4c42d8f3e9333db,"Hainan General Hospital, Geriatric center, China; Hainan General Hospital, Medical Laboratory, China; Hainan General Hospital, General Practice, China","Liu, K., Hainan General Hospital, Geriatric center, China; Chen, Y., Hainan General Hospital, Medical Laboratory, China; Lin, R., Hainan General Hospital, General Practice, China; Han, K., Hainan General Hospital, General Practice, China","Background: Due to the general susceptibility of new coronaviruses, the clinical characteristics and outcomes of elderly and young patients may be different. Objective: To analyze the clinical characteristics of elderly patients with 2019 new-type coronavirus pneumonia (COVID-19). Methods: This is a retrospective study of patients with new coronavirus pneumonia (COVID-19) who were hospitalized in Hainan Provincial People's Hospital from January 15, 2020 to February 18, 2020. Compare the clinical characteristics of elderly with Young and Middle-aged patients. Results: A total of 56 patients were enrolled 18 elderly patients (32.14%), and 38 young and middle-aged patients (67.86%). The most common symptoms in both groups were fever, followed by cough and sputum. Four patients in the elderly group received negative pressure ICU for mechanical ventilation, and five patients in the young and middle-aged group. One patient died in the elderly group (5.56%), and two patients died in the young and middle-aged group (5.26%). The PSI score of the elderly group was higher than that of the young and middle-aged group (P < 0.001). The proportion of patients with PSI grades IV and V was significantly higher in the elderly group than in the young and middle-aged group (P < 0.05). The proportion of multiple lobe involvement in the elderly group was higher than that in the young and middle-aged group (P < 0.001), and there was no difference in single lobe lesions between the two groups. The proportion of lymphocytes in the elderly group was significantly lower than that in the young and middle-aged group (P < 0.001), and the C-reactive protein was significantly higher in the young group (P < 0.001). The Lopinavir and Ritonavir Tablets, Chinese medicine, oxygen therapy, and mechanical ventilation were statistically different in the elderly group and the young and middle-aged group, and the P values were all <0.05. Interpretation: The mortality of elderly patients with COVID-19 is higher than that of young and middle-aged patients, and the proportion of patients with PSI grade IV and V is significantly higher than that of young and middle-aged patients. Elderly patients with COVID-19 are more likely to progress to severe disease. © 2020",Clinical feature; COVID-19; Elderly patients; Young and middle-aged patients,,"Li, J.-Y., You, Z., The epidemic of 2019-novel-coronavirus (2019-nCoV) pneumonia and insights for emerging infectious diseases in the future (2020) Microbes Infect, , In press, journal pre-proof Available online 20 February 2020; Guan, W.J., Ni, Z.Y., Zhong, N.S., (2020), Clinical characteristics of 2019 novel coronavirus infection in China. Med Rxiv [Epub ahead of print]; Yang, Y., Lu, Q.B., Liu, M.J., (2020), Epidemiological and clinical features of the 2019 novel coronavirus outbreak in China. Med Rxiv [Epub ahead of print]. DOI:; Liu, Y., Gayle, A.A., Wilder-Smith, A., The reproductive number of COVID−19 is higher compared to SARS coronavirus (2020) J Travel Med, , [Epub ahead of print]; Prompetchara, E., Ketloy, C., Palaga, T., Immune responses in COVID-19 and potential vaccines: lessons learned from SARS and MERSepidemic (2020) Asian Pac J Allergy Immunol; Park, M., Thwaites, R.S., Openshaw, P.J.M., COVID-19: lessons from SARS and MERS (2020) Eur J Immunol; Yao, T.T., Qian, J.D., Zhu, W.Y., A systematic review of lopinavir therapy for sars coronavirus and mers coronavirus-a possible reference for coronavirus disease-19 treatment option (2020) J Med Virol; Zuo, M.Z., Huang, Y.G., Ma, W.H., Expert recommendations for tracheal intubation in critically ill patients with noval coronavirusdisease 2019 (2020) Chin Med Sci J; Xu, J., Zhao, S., Teng, T., Systematic comparison of two animal-to-human transmitted human coronaviruses: SARS-CoV-2 and SARS-CoV (2020) Viruses, 12 (2). , pii: E244; Peeri, N.C., Shrestha, N., Rahman, M.S., The SARS, MERS and novel coronavirus (COVID-19) epidemics, the newest and biggest global health threats: what lessons have we learned? (2020) Int J Epidemiol., , pii: dyaa033; Lin, C., Ding, Y., Xie, B., Asymptomatic novel coronavirus pneumonia patient outside Wuhan: the value of CT images in the course of the disease (2020) Clin Imaging, 63, pp. 7-9; Xu, X.W., Wu, X.X., Jiang, X.G., Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series (2020) BMJ, 368, p. m606; Liu, W., Tao, Z.W., Lei, W., Analysis of factors associated with disease outcomes in hospitalized patients with 2019 novelcoronavirus disease (2020) Chin Med J; Wang, N.L., Jie, Y., Tao, F.B., Precautions in ophthalmic practice in the prevention and control of the novel coronaviruspneumonia epidemic (2020) Zhonghua Yan Ke Za Zhi, 56 (0), p. E007; Tian, S., Hu, W., Niu, L., Pulmonary pathology of early phase 2019 novel coronavirus (COVID-19) pneumonia in two patients with lung cancer (2020) J Thorac Oncol, , pii: S1556-0864(20)30132-5","Liu, K.; Hainan General Hospital, Geriatric centerChina; email: hmliukai@126.com",,W.B. Saunders Ltd,1634453,,JINFD,32171866,English,J. Infect.,Review,Article in Press,Open Access,Scopus,2-s2.0-85082527843,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Xie B., He D., Mercer T., Wang Y., Wu D., Fleischmann K.R., Zhang Y., Yoder L.H., Stephens K.K., Mackert M., Lee M.K.",35313224300;15044318000;56992687700;57215721110;57215723284;9534990600;36621406100;7007115888;9336961600;8729573300;57215716410;,Global health crises are also information crises: A call to action,2020,Journal of the Association for Information Science and Technology,,,,,,,,10.1002/asi.24357,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081737846&doi=10.1002%2fasi.24357&partnerID=40&md5=143b7fdd515d2db5179736513e8b12a8,"School of Nursing, The University of Texas at Austin, Austin, TX, United States; School of Information, The University of Texas at Austin, Austin, TX, United States; Department of Informatics and Networked Systems, School of Computing and Information, University of Pittsburgh, Pittsburgh, PA, United States; Department of Population Health, Dell Medical School, The University of Texas at Austin, Austin, TX, United States; Department of Internal Medicine, Dell Medical School, The University of Texas at Austin, Austin, TX, United States; Global Health Institute, Xi'an Jiaotong University Health Science Center, Xi'an, China; School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China; Department of Nutrition and Health Science, College of Health, Fisher Institute of Health and Well-Being, Ball State University, Muncie, IN, United States; School of Information Management, Wuhan University, Wuhan, China; Department of Communication Studies, Moody College of Communication, The University of Texas at Austin, Austin, TX, United States; Center for Health Communication, Moody College of Communication, The University of Texas at Austin, Austin, TX, United States; Stan Richards School of Advertising and Public Relations, Moody College of Communication, The University of Texas at Austin, Austin, TX, United States","Xie, B., School of Nursing, The University of Texas at Austin, Austin, TX, United States, School of Information, The University of Texas at Austin, Austin, TX, United States; He, D., Department of Informatics and Networked Systems, School of Computing and Information, University of Pittsburgh, Pittsburgh, PA, United States; Mercer, T., Department of Population Health, Dell Medical School, The University of Texas at Austin, Austin, TX, United States, Department of Internal Medicine, Dell Medical School, The University of Texas at Austin, Austin, TX, United States; Wang, Y., Global Health Institute, Xi'an Jiaotong University Health Science Center, Xi'an, China, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China, Department of Nutrition and Health Science, College of Health, Fisher Institute of Health and Well-Being, Ball State University, Muncie, IN, United States; Wu, D., School of Information Management, Wuhan University, Wuhan, China; Fleischmann, K.R., School of Information, The University of Texas at Austin, Austin, TX, United States; Zhang, Y., School of Information, The University of Texas at Austin, Austin, TX, United States; Yoder, L.H., School of Nursing, The University of Texas at Austin, Austin, TX, United States; Stephens, K.K., Department of Communication Studies, Moody College of Communication, The University of Texas at Austin, Austin, TX, United States; Mackert, M., Department of Population Health, Dell Medical School, The University of Texas at Austin, Austin, TX, United States, Center for Health Communication, Moody College of Communication, The University of Texas at Austin, Austin, TX, United States, Stan Richards School of Advertising and Public Relations, Moody College of Communication, The University of Texas at Austin, Austin, TX, United States; Lee, M.K., School of Information, The University of Texas at Austin, Austin, TX, United States","In this opinion paper, we argue that global health crises are also information crises. Using as an example the coronavirus disease 2019 (COVID-19) epidemic, we (a) examine challenges associated with what we term “global information crises”; (b) recommend changes needed for the field of information science to play a leading role in such crises; and (c) propose actionable items for short- and long-term research, education, and practice in information science. © 2020 Association for Information Science and Technology",,Coronaviruses; Global health; Global informations,"Beaglehole, R., Bonita, R., What is global health? (2010) Global Health Action, 3, p. 5142. , https://doi.org/10.3402/gha.v3i0.5142; Buckley, C., Wee, S.L., Qin, A., (2020), https://www.nytimes.com/2020/02/14/world/asia/china-coronavirus-doctors.html, . China's doctors, fighting the coronavirus, beg for masks., The New York Times, Retrieved from; (2020), https://www.cdc.gov/coronavirus/2019-ncov/summary.html, Coronavirus disease 2019 (COVID-19) situation summary, Retrieved from; D'Urbino, L., (2020), https://www.economist.com/china/2020/02/17/the-coronavirus-spreads-racism-against-and-among-ethnic-chinese, February 17). The coronavirus spreads racism against—and among—ethnic Chinese., The Economist, Retrieved from; Iqbal, N., (2020), https://www.theguardian.com/world/2020/feb/01/coronavirus-weaponised-way-to-be-openly-racist, February 1). Coronavirus fears fuel racism and hostility, say British-Chinese., The Guardian, Retrieved from; Koplan, J.P., Bond, T.C., Merson, M.H., Reddy, K.S., Rodriguez, M.H., Sewankambo, N.K., Wasserheit, J.N., Towards a common definition of global health (2009) Lancet, 373 (9679), pp. 1993-1995. , https://doi.org/10.1016/s0140-6736(09)60332-9; Liu, S.B., Palen, L., Giaccardi, E., Heritage matters in crisis informatics: How information and communication technology can support legacies of crisis events (2012) Crisis information management: Communication and technologies, pp. 65-86. , C. Hagar, (Ed.),, Cambridge, England, Chandos Publishing; Norman, C.D., Skinner, H.A., eHealth literacy: Essential skills for consumer health in a networked world (2006) Journal of Medical Internet Research, 8 (2). , https://doi.org/10.2196/jmir.8.2.e9; O'Neal, A., Rodgers, B., Segler, J., Murthy, D., Lakuduva, N., Johnson, M., Stephens, K.K., (2018), Training an emergency-response image classifier on signal data, Paper presented at the Proceedings of the IEEE 17th International Conference on Machine Learning and Applications ICMLA, Orlando, FL; Palen, L., Hiltz, S.R., Liu, S.B., Online forums supporting grassroots participation in emergency preparedness and response (2007) Communications of the ACM, 50, pp. 54-58; Palen, L., Hughes, A.L., Social media in disaster communication (2018) Handbook of disaster research, pp. 497-520. , H. Rodriguez, W. Donner, J. E. Trainor, (Eds.),, 2nd ed., Cham, Switzerland, Springer; Pang, N., Karanasios, S., Anwar, M., Exploring the information worlds of older persons during disasters Journal of the Association for Information Science and Technology, , https://doi.org/10.1002/asi.24294, (in press); Rahmi, R., Joho, H., Shirai, T., An analysis of natural disaster-related information-seeking behavior using temporal stages (2019) Journal of the Association for Information Science and Technology, 70, pp. 715-728; Signorini, A., Segre, A.M., Polgreen, P.M., The use of twitter to track levels of disease activity and public concern in the U.S. during the influenza a H1N1 pandemic (2011) PLoS One, 6 (5). , https://doi.org/10.1371/journal.pone.0019467; Soden, R., Palen, L., (2018), Informating crisis Expanding critical perspectives on crisis informatics, Paper presented at the Proceedings of the ACM Conference on Computer Supported Cooperative Work, New York City; Stephens, K.K., Li, J., Robertson, B.W., Smith, W.R., Murthy, D., Citizens communicating health information: Urging others in their community to seek help during a flood (2018) Proceedings of the 15th International ISCRAM Conference, , K. Boersma, &, B. Tomaszewski, (Eds.),, Rochester, NY, May; (2020), https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports/, Coronavirus disease (COVID-2019) situation report - 35, Retrieved from; Xie, B., Zhou, L., Yoder, L., Johnson, K., Garcia, A., Kim, M., Ebola-related health information wanted and obtained by hospital and public health department employees: Effects of formal and informal communication channels (2019) Disaster Medicine and Public Health Preparedness, pp. 1-10. , https://doi.org/10.1017/dmp.2019.45; Yasinski, E., (2020), https://www.the-scientist.com/news-opinion/can-social-media-inform-public-health-efforts–66891, . Can social media inform public health efforts?, The Scientist, Retrieved from","Xie, B.; School of Nursing, The University of Texas at AustinUnited States; email: boxie@utexas.edu",,John Wiley and Sons Inc.,23301635,,,,English,J. Assoc. Soc. Inf. Sci. Technol.,Article,Article in Press,Open Access,Scopus,2-s2.0-85081737846,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Bénézit F., Loubet P., Galtier F., Pronier C., Lenzi N., Lesieur Z., Jouneau S., Lagathu G., L’Honneur A.-S., Foulongne V., Vallejo C., Alain S., Duval X., Houhou N., Costa Y., Vanhems P., Amour S., Carrat F., Lina B., Launay O., Tattevin P., Loulergue P., Momcilovic S., Mira J.P., Marin N., Regent A., Kanaan, Dumas F., Doumenc B., Alexandra J.F., Becheur H., Belghalem K., Bernard J., Bleitreu A., Boisseau M., Bories R., Brugiere O., Brunet F., Burdet C., Casalino E., Caseris M., Chansiaux, Chauchard M., Chavance P., Choquet C., Cloppet-Fontaine, Colosi L., Couset B., Crestani B., Crocket F., Debit A., Delanoe, Descamps V., Dieude P., Dossier A., Douron N., Dupeyrat E., Emeyrat N., Fernet, Goulenok T., Harent S., Jouenne, Justet A., Lachatre M., Leleu A., Lerat I., Lilamand M., Mal H., Marceau A., Metivier A.-C., Oplelatora K., Papo T., Pelletier A.-L., Pereira L., Pradere P., Prommier, Ralainnazava P., Ranaivoision M., Raynaud-Simon A., Rioux C., Sacre K., Verry V., Vuong V., Yazdapanah Y., Géraud P., Driss V., Maugueret V., Ray M., Letois F., Mura T., Merle C., Bourdin A., Konaté A., Capdevilla X., Du Cailar G., Terminet A., Blain H., Leglise M.-S., Le Quellec A., Corne P., Landreau L., Klouche K., Bourgeois A., Sebbane M., Mourad G., Leray H., Maarouf M., Postil D., Alcolea S., Couve Deacon E., Rogez S., Argaud L., Tazarourte K., Hernu R., Cour M., Simon M., Baudry T., Jacquin L., Lainé F., Laviolle B., Allain J.-S., Belhomme N., Thibault V., Rochas S., Cochennec S., Ouamara-Digue E., Lepape C., Revest M., Simon S., Fouchard J., Gautier C., Nouredine N., Thébault E., The FLUVAC Study Group",56966567800;56294581100;6603837322;56550035200;54795370700;56584711600;25226653000;15050700400;57201197519;8679637400;7005972760;6701589182;7004180081;56769614100;24066617600;7005124320;54683384900;55565516400;7006493939;17635344700;7003361868;23005619500;56615852000;57215512838;7003569878;26424783500;57214912083;14622591300;24447964800;15848007800;6701395905;57188839971;55803478400;57214915371;57100526500;56584632700;6701522392;57214981808;55807046000;7004453501;55906681800;57214915577;57215765695;57188835341;36838131800;57214912911;15757246700;57214914412;14007929800;57214916533;55803479000;57214914941;7005308853;56206750400;36090674500;57214917277;57188836041;57188836610;57214912036;35558688300;55615347100;57214914678;56174112500;55813447600;56471755600;57214915671;7801546447;55676155800;57215947227;57214912318;57214913533;7006185279;36948163100;19035724000;57209678929;57214916154;57214912504;57214913245;6603326236;16643650100;25227882800;57188841621;57214916832;56584493200;56698327600;56971576800;57214915892;56583478300;36169126700;57214914185;57159281600;57213080182;57195101501;57214913017;57214916475;35306151800;57214913113;56076771100;7004851627;7003694628;6603065812;7004215218;57214914982;8909027100;57214910510;57214914725;57214911831;56230253500;56584285700;57008302000;57190678245;6603381362;23006800500;47061286100;57214976331;57212417052;48261111400;57214982337;7005781224;8358863900;57214916868;57192872991;57212703815;57214912437;57214915256;56716426600;57214913619;8662357400;57214944377;57214981018;57213861085;57214911284;56698155800;,Non-influenza respiratory viruses in adult patients admitted with influenza-like illness: a 3-year prospective multicenter study,2020,Infection,,,,,,,,10.1007/s15010-019-01388-1,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079478660&doi=10.1007%2fs15010-019-01388-1&partnerID=40&md5=3b22d402fff0d51bdc4cf0a0d7662d76,"Université Rennes-I, Service Des Maladies Infectieuses et de Réanimation Médicale, Hôpital Pontchaillou, CHU Pontchaillou, 2 rue Henri Le Guilloux, Rennes Cedex, 35033, France; Université Paris Descartes, Sorbonne Paris Cité; Inserm, CIC Cochin Pasteur, Innovative Clinical Research Network in VACcinology (I-REIVAC), Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France; Inserm, F-CRIN, Innovative Clinical Research Network in Vaccinology (I-REIVAC), Paris, France; CIC1411, CHU Montpellier, Hôpital Saint Eloi, Montpellier, 34295, France; Université Rennes-I, Virologie, Hôpital Pontchaillou, Rennes, France; Université Rennes-I, Pneumologie, Hôpital Pontchaillou, Rennes, France; Inserm, CIC 1414, Université Rennes-I, Hôpital Pontchaillou, Rennes, France; AHU, Service de Virologie, Hôpital Cochin, Paris, France; Service de Virologie, CHU Montpellier, Hôpital Saint Eloi, Montpellier, 34295, France; INSERM CIC 1435, CHU Dupuytren, Limoges, France; Univ. Limoges, INSERM, CHU Limoges, RESINFIT, U1092, Limoges, 87000, France; CIC1125, Hôpital Bichat Claude Bernard, APHP, Inserm, F-CRIN, Innovative Clinical Research Network in Vaccinology (I-REIVAC), Paris, France; Laboratoire de Virologie, Hôpital Bichat Claude Bernard, Paris, France; Service D’Hygiène, Epidémiologie et Prévention, Hospices Civils de Lyon, Lyon, 69437, France; Laboratoire des Pathogènes Emergents-Fondation Mérieux, Centre International de Recherche en Infectiologie, Institut National de la Santé et de la Recherche Médicale U1111, Centre National de La Recherche Scientifique, UMR5308, Ecole Normale Supérieure de Lyon, Université Claude Bernard Lyon, Lyon, France; Sorbonne Université, INSERM, Institut Pierre Louis D’Epidémiologie et de Santé Publique IPLESP, AP-HP, Hôpital Saint Antoine, Paris, 75013, France; Hospices Civils de Lyon, Laboratoire de Virologie, Institut Des Agents Infectieux (IAI), Centre National de Référence Des Virus Respiratoires France Sud, Hôpital de La Croix-Rousse, Lyon Cedex 04, 69317, France","Bénézit, F., Université Rennes-I, Service Des Maladies Infectieuses et de Réanimation Médicale, Hôpital Pontchaillou, CHU Pontchaillou, 2 rue Henri Le Guilloux, Rennes Cedex, 35033, France; Loubet, P., Université Paris Descartes, Sorbonne Paris Cité; Inserm, CIC Cochin Pasteur, Innovative Clinical Research Network in VACcinology (I-REIVAC), Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France; Galtier, F., Inserm, F-CRIN, Innovative Clinical Research Network in Vaccinology (I-REIVAC), Paris, France, CIC1411, CHU Montpellier, Hôpital Saint Eloi, Montpellier, 34295, France; Pronier, C., Université Rennes-I, Virologie, Hôpital Pontchaillou, Rennes, France; Lenzi, N., Université Paris Descartes, Sorbonne Paris Cité; Inserm, CIC Cochin Pasteur, Innovative Clinical Research Network in VACcinology (I-REIVAC), Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France; Lesieur, Z., Université Paris Descartes, Sorbonne Paris Cité; Inserm, CIC Cochin Pasteur, Innovative Clinical Research Network in VACcinology (I-REIVAC), Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France; Jouneau, S., Université Rennes-I, Pneumologie, Hôpital Pontchaillou, Rennes, France, Inserm, CIC 1414, Université Rennes-I, Hôpital Pontchaillou, Rennes, France; Lagathu, G., Université Rennes-I, Virologie, Hôpital Pontchaillou, Rennes, France; L’Honneur, A.-S., AHU, Service de Virologie, Hôpital Cochin, Paris, France; Foulongne, V., Service de Virologie, CHU Montpellier, Hôpital Saint Eloi, Montpellier, 34295, France; Vallejo, C., INSERM CIC 1435, CHU Dupuytren, Limoges, France; Alain, S., Univ. Limoges, INSERM, CHU Limoges, RESINFIT, U1092, Limoges, 87000, France; Duval, X., CIC1125, Hôpital Bichat Claude Bernard, APHP, Inserm, F-CRIN, Innovative Clinical Research Network in Vaccinology (I-REIVAC), Paris, France; Houhou, N., Laboratoire de Virologie, Hôpital Bichat Claude Bernard, Paris, France; Costa, Y., CIC1125, Hôpital Bichat Claude Bernard, APHP, Inserm, F-CRIN, Innovative Clinical Research Network in Vaccinology (I-REIVAC), Paris, France; Vanhems, P., Service D’Hygiène, Epidémiologie et Prévention, Hospices Civils de Lyon, Lyon, 69437, France, Laboratoire des Pathogènes Emergents-Fondation Mérieux, Centre International de Recherche en Infectiologie, Institut National de la Santé et de la Recherche Médicale U1111, Centre National de La Recherche Scientifique, UMR5308, Ecole Normale Supérieure de Lyon, Université Claude Bernard Lyon, Lyon, France; Amour, S., Service D’Hygiène, Epidémiologie et Prévention, Hospices Civils de Lyon, Lyon, 69437, France; Carrat, F., Sorbonne Université, INSERM, Institut Pierre Louis D’Epidémiologie et de Santé Publique IPLESP, AP-HP, Hôpital Saint Antoine, Paris, 75013, France; Lina, B., Hospices Civils de Lyon, Laboratoire de Virologie, Institut Des Agents Infectieux (IAI), Centre National de Référence Des Virus Respiratoires France Sud, Hôpital de La Croix-Rousse, Lyon Cedex 04, 69317, France; Launay, O., Université Paris Descartes, Sorbonne Paris Cité; Inserm, CIC Cochin Pasteur, Innovative Clinical Research Network in VACcinology (I-REIVAC), Assistance Publique Hôpitaux de Paris, Hôpital Cochin, Paris, France; Tattevin, P., Université Rennes-I, Service Des Maladies Infectieuses et de Réanimation Médicale, Hôpital Pontchaillou, CHU Pontchaillou, 2 rue Henri Le Guilloux, Rennes Cedex, 35033, France, Inserm, CIC 1414, Université Rennes-I, Hôpital Pontchaillou, Rennes, France; Loulergue, P.; Momcilovic, S.; Mira, J.P.; Marin, N.; Regent, A.; Kanaan; Dumas, F.; Doumenc, B.; Alexandra, J.F.; Becheur, H.; Belghalem, K.; Bernard, J.; Bleitreu, A.; Boisseau, M.; Bories, R.; Brugiere, O.; Brunet, F.; Burdet, C.; Casalino, E.; Caseris, M.; Chansiaux; Chauchard, M.; Chavance, P.; Choquet, C.; Cloppet-Fontaine; Colosi, L.; Couset, B.; Crestani, B.; Crocket, F.; Debit, A.; Delanoe; Descamps, V.; Dieude, P.; Dossier, A.; Douron, N.; Dupeyrat, E.; Emeyrat, N.; Fernet; Goulenok, T.; Harent, S.; Jouenne; Justet, A.; Lachatre, M.; Leleu, A.; Lerat, I.; Lilamand, M.; Mal, H.; Marceau, A.; Metivier, A.-C.; Oplelatora, K.; Papo, T.; Pelletier, A.-L.; Pereira, L.; Pradere, P.; Prommier; Ralainnazava, P.; Ranaivoision, M.; Raynaud-Simon, A.; Rioux, C.; Sacre, K.; Verry, V.; Vuong, V.; Yazdapanah, Y.; Géraud, P.; Driss, V.; Maugueret, V.; Ray, M.; Letois, F.; Mura, T.; Merle, C.; Bourdin, A.; Konaté, A.; Capdevilla, X.; Du Cailar, G.; Terminet, A.; Blain, H.; Leglise, M.-S.; Le Quellec, A.; Corne, P.; Landreau, L.; Klouche, K.; Bourgeois, A.; Sebbane, M.; Mourad, G.; Leray, H.; Maarouf, M.; Postil, D.; Alcolea, S.; Couve Deacon, E.; Rogez, S.; Argaud, L.; Tazarourte, K.; Hernu, R.; Cour, M.; Simon, M.; Baudry, T.; Jacquin, L.; Lainé, F.; Laviolle, B.; Allain, J.-S.; Belhomme, N.; Thibault, V.; Rochas, S.; Cochennec, S.; Ouamara-Digue, E.; Lepape, C.; Revest, M.; Simon, S.; Fouchard, J.; Gautier, C.; Nouredine, N.; Thébault, E.; The FLUVAC Study Group","Purpose: To describe the burden, and characteristics, of influenza-like illness (ILI) associated with non-influenza respiratory viruses (NIRV). Methods: We performed a prospective, multicenter, observational study of adults admitted with ILI during three influenza seasons (2012–2015). Patients were screened for picornavirus, respiratory syncytial virus (RSV), coronavirus, human metapneumovirus, adenovirus, bocavirus, parainfluenza virus, and influenza, by PCR on nasopharyngeal samples. We excluded patients coinfected with NIRV and influenza. Results: Among 1421 patients enrolled, influenza virus was detected in 535 (38%), and NIRV in 215 (15%), mostly picornavirus (n = 61), RSV (n = 53), coronavirus 229E (n = 48), and human metapneumovirus (n = 40). In-hospital mortality was 5% (NIRV), 4% (influenza), and 5% (no respiratory virus). As compared to influenza, NIRV were associated with age (median, 73 years vs. 68, P = 0.026), chronic respiratory diseases (53% vs. 45%, P = 0.034), cancer (14% vs. 9%, P = 0.029), and immunosuppressive drugs (21% vs. 14%, P = 0.028), and inversely associated with diabetes (18% vs. 25%, P = 0.038). On multivariable analysis, only chronic respiratory diseases (OR 1.5 [1.1–2.0], P = 0.008), and diabetes (OR 0.5 [0.4–0.8], P = 0.01) were associated with NIRV detection. Conclusions: NIRV are common in adults admitted with ILI during influenza seasons. Outcomes are similar in patients with NIRV, influenza, or no respiratory virus. © 2020, Springer-Verlag GmbH Germany, part of Springer Nature.",Coronavirus; Human metapneumovirus; Influenza; Influenza-like illness; Picornavirus; Respiratory syncytial virus,,"Ruuskanen, O., Lahti, E., Jennings, L.C., Murdoch, D.R., Viral pneumonia (2011) Lancet Lond Engl, 377, pp. 1264-1275; Luchsinger, V., Ruiz, M., Zunino, E., Martínez, M.A., Machado, C., Piedra, P.A., Community-acquired pneumonia in Chile: the clinical relevance in the detection of viruses and atypical bacteria (2013) Thorax, 68, pp. 1000-1006; van den Hoogen, B.G., de Jong, J.C., Groen, J., Kuiken, T., de Groot, R., Fouchier, R.A.M., A newly discovered human pneumovirus isolated from young children with respiratory tract disease (2001) Nat Med, 7, pp. 719-724; Allander, T., Tammi, M.T., Eriksson, M., Bjerkner, A., Tiveljung-Lindell, A., Andersson, B., Cloning of a human parvovirus by molecular screening of respiratory tract samples (2005) Proc Natl Acad Sci USA, 102, pp. 12891-12896; Pavia, A.T., What is the role of respiratory viruses in community-acquired pneumonia? What is the best therapy for influenza and other viral causes of community-acquired pneumonia? (2013) Infect Dis Clin North Am, 27, pp. 157-175; Galván, J.M., Rajas, O., Aspa, J., Review of non-bacterial infections in respiratory medicine: viral pneumonia (2015) Arch Bronconeumol Engl Ed, 51, pp. 590-597; (2019) . Influenza Case Definitions, , https://ecdc.europa.eu/en/healthtopics/influenza/surveillance/Pages/influenza_case_definitions.aspx, Accessed 9 Jan 2020; Rondy, M., Puig-Barbera, J., Launay, O., Duval, X., Castilla, J., Guevara, M., 2011–12 seasonal influenza vaccines effectiveness against confirmed A(H3N2) influenza hospitalisation: pooled analysis from a European network of hospitals. A pilot study (2013) PLoS One, 8; Loubet, P., Samih-Lenzi, N., Galtier, F., Vanhems, P., Loulergue, P., Duval, X., Factors associated with poor outcomes among adults hospitalized for influenza in France: a three-year prospective multicenter study (2016) J Clin Virol, 79, pp. 68-73; Loubet, P., Lenzi, N., Valette, M., Foulongne, V., Krivine, A., Houhou, N., Clinical characteristics and outcome of respiratory syncytial virus infection among adults hospitalized with influenza-like illness in France (2017) Clin Microbiol Infect, 23, pp. 253-259; Bouscambert Duchamp, M., Casalegno, J.S., Gillet, Y., Frobert, E., Bernard, E., Escuret, V., Pandemic A(H1N1)2009 influenza virus detection by real time RT-PCR: is viral quantification useful? (2010) Clin Microbiol Infect, 16, pp. 317-321; (2019), https://www.r-project.org/; Tanner, H., Boxall, E., Osman, H., Respiratory viral infections during the 2009–2010 winter season in Central England, UK: incidence and patterns of multiple virus co-infections (2012) Eur J Clin Microbiol Infect Dis Off Publ Eur Soc Clin Microbiol, 31, pp. 3001-3006; Ambrosioni, J., Bridevaux, P.-O., Wagner, G., Mamin, A., Kaiser, L., Epidemiology of viral respiratory infections in a tertiary care centre in the era of molecular diagnosis, Geneva, Switzerland, 2011–2012 (2014) Clin Microbiol Infect Off Publ Eur Soc Clin Microbiol Infect Dis, 20, pp. O578-O584; Falsey, A.R., Hennessey, P.A., Formica, M.A., Cox, C., Walsh, E.E., Respiratory syncytial virus infection in elderly and high-risk adults (2005) N Engl J Med, 352, pp. 1749-1759; Zwaans, W.A.R., Mallia, P., van Winden, M.E.C., Rohde, G.G.U., The relevance of respiratory viral infections in the exacerbations of chronic obstructive pulmonary disease—A systematic review (2014) Journal of Clinical Virology, 61 (2), pp. 181-188. , https://doi.org/10.1016/j.jcv.2014.06.025, COI: 1:STN:280:DC%2BC2cbmsFGltA%3D%3D; Gunawardana, N., Finney, L., Johnston, S.L., Mallia, P., Experimental rhinovirus infection in COPD: implications for antiviral therapies (2014) Antiviral Res, 102, pp. 95-105; Mallia, P., Message, S.D., Gielen, V., Contoli, M., Gray, K., Kebadze, T., Experimental rhinovirus infection as a human model of chronic obstructive pulmonary disease exacerbation (2011) Am J Respir Crit Care Med, 183, pp. 734-742; Shah, B.R., Hux, J.E., Quantifying the risk of infectious diseases for people with diabetes (2003) Diabetes Care, 26, pp. 510-513; Pearson-Stuttard, J., Blundell, S., Harris, T., Cook, D.G., Critchley, J., Diabetes and infection: assessing the association with glycaemic control in population-based studies (2016) Lancet Diabetes Endocrinol, 4, pp. 148-158; Muller, L.M.A.J., Gorter, K.J., Hak, E., Goudzwaard, W.L., Schellevis, F.G., Hoepelman, A.I.M., Rutten, G.E.H.M., Increased Risk of Common Infections in Patients with Type 1 and Type 2 Diabetes Mellitus (2005) Clinical Infectious Diseases, 41 (3), pp. 281-288. , https://doi.org/10.1086/431587, COI: 1:STN:280:DC%2BD2Mzlt1GgsQ%3D%3D; Jain, S., Self, W.H., Wunderink, R.G., Fakhran, S., Balk, R., Bramley, A.M., Reed, C., Finelli, L., Community-Acquired Pneumonia Requiring Hospitalization among U.S. Adults (2015) New England Journal of Medicine, 373 (5), pp. 415-427. , https://doi.org/10.1056/NEJMoa1500245, COI: 1:CAS:528:DC%2BC2MXhtlyktLvK","Tattevin, P.; Université Rennes-I, Service Des Maladies Infectieuses et de Réanimation Médicale, Hôpital Pontchaillou, CHU Pontchaillou, 2 rue Henri Le Guilloux, France; email: pierre.tattevin@chu-rennes.fr",,Springer,3008126,,IFTNA,32056143,English,Infection,Article,Article in Press,Open Access,Scopus,2-s2.0-85079478660,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Benvenuto D., Giovanetti M., Salemi M., Prosperi M., De Flora C., Junior Alcantara L.C., Angeletti S., Ciccozzi M.",57208408457;55486066500;7004151299;22036230400;57202994750;57201638717;7003426796;8791594200;,The global spread of 2019-nCoV: a molecular evolutionary analysis,2020,Pathogens and Global Health,,,,,,,1,10.1080/20477724.2020.1725339,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079410907&doi=10.1080%2f20477724.2020.1725339&partnerID=40&md5=6dfe1b433dbc23454499c296efe3abb0,"Unit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome, Italy; Laboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil; Department of Epidemiology, University of Florida, Gainesville, FL, United States; Emerging Pathogens Institute, University of Florida, Gainesville, FL, United States; Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome, Italy","Benvenuto, D., Unit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome, Italy; Giovanetti, M., Laboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil; Salemi, M., Department of Epidemiology, University of Florida, Gainesville, FL, United States, Emerging Pathogens Institute, University of Florida, Gainesville, FL, United States; Prosperi, M., Department of Epidemiology, University of Florida, Gainesville, FL, United States, Emerging Pathogens Institute, University of Florida, Gainesville, FL, United States; De Flora, C., Unit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome, Italy; Junior Alcantara, L.C., Laboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil; Angeletti, S., Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome, Italy; Ciccozzi, M., Laboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil","The global spread of the 2019-nCoV is continuing and is fast moving, as indicated by the WHO raising the risk assessment to high. In this article, we provide a preliminary phylodynamic and phylogeographic analysis of this new virus. A Maximum Clade Credibility tree has been built using the 29 available whole genome sequences of 2019-nCoV and two whole genome sequences that are highly similar sequences from Bat SARS-like Coronavirus available in GeneBank. We are able to clarify the mechanism of transmission among the countries which have provided the 2019-nCoV sequence isolates from their patients. The Bayesian phylogeographic reconstruction shows that the 2019–2020 nCoV most probably originated from the Bat SARS-like Coronavirus circulating in the Rhinolophus bat family. In agreement with epidemiological observations, the most likely geographic origin of the new outbreak was the city of Wuhan, China, where 2019-nCoV time of the most recent common ancestor emerged, according to molecular clock analysis, around November 25th, 2019. These results, together with previously recorded epidemics, suggest a recurring pattern of periodical epizootic outbreaks due to Betacoronavirus. Moreover, our study describes the same population genetic dynamic underlying the SARS 2003 epidemic, and suggests the urgent need for the development of effective molecular surveillance strategies of Betacoronavirus among animals and Rhinolophus of the bat family. © 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group.",2019-nCoV; molecular Epidemiology; phylogeny; SARS,,"Weiss, S.R., Leibowitz, J.L., Coronavirus pathogenesis (2011) Adv Virus Res, 81, pp. 85-164; Drosten, C., Günther, S., Preiser, W., Identification of a novel coronavirus associated with severe acute respiratory syndrome (2003) N Engl J Med, 348 (20), pp. 1967-1976; Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, , Jan, 24; Lu, H., Stratton, C.W., Tang, Y.W., Outbreak of pneumonia of unknown etiology in Wuhan China: the mystery and the miracle (2020) J Med Virol; Ji, W., Wang, W., Zhao, X., Homologous recombination within the spike glycoprotein of the newly identified coronavirus may boost cross‐species transmission from snake to human (2020) J Med Virol, , Jan, 22; Heymann, D.L., Emerging understandings of 2019-nCoV (2020) Lancet, , Jan, 24; Katoh, K., Rozewicki, J., Yamada, K.D., MAFFT online service: multiple sequence alignment, interactive sequence choice and visualization (2017) Brief Bioinform, , 20(4): 1160–1166; Nguyen, L.T., Schmidt, H.A., von Haeseler, A., IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies (2015) Mol Biol Evol, 32 (1), pp. 268-274; Darriba, D., Taboada, G.L., Doallo, R., jModelTest 2: more models, new heuristics and parallel computing (2012) Nat Methods, 9 (8), p. 772; Rambaut, A., Lam, T.T., Max Carvalho, L., Exploring the temporal structure of heterochronous sequences using TempEst (formerly Path-O-Gen) (2016) Virus Evol, 2 (1), p. vew007; Suchard, M.A., Lemey, P., Baele, G., Bayesian phylogenetic and phylodynamic data integration using BEAST 1.10 (2018) Virus Evol, 4 (1), p. vey016; Baele, G., Li, W.L., Drummond, A.J., Accurate model selection of relaxed molecular clocks in Bayesian phylogenetics (2013) Mol Biol Evol, 30 (2), pp. 239-243; Drummond, A.J., Ho, S.Y., Phillips, M.J., Relaxed phylogenetics and dating with confidence (2006) PLoS Biol, 4 (5), p. e88; Rambaut, A., Drummond, A.J., Xie, D., Posterior summarization in Bayesian phylogenetics using tracer 1.7 (2018) Syst Biol, 67 (5), pp. 901-904; Salemi, M., Fitch, W.M., Ciccozzi, M., SARS-CoV sequence characteristics and evolutionary rate estimate from maximum likelihood analysis (2004) J Virol, 78, pp. 1602-1603; Lau, S.K., Li, K.S., Huang, Y., Ecoepidemiology and complete genome comparison of different strains of severe acute respiratory syndrome-related Rhinolophus bat coronavirus in China reveal bats as a reservoir for acute, self-limiting infection that allows recombination events (2010) J Virol, 84 (6), pp. 2808-2819","Angeletti, S.; Unit of Clinical Laboratory Science, University Campus Bio-Medico of RomeItaly; email: s.angeletti@unicampus.it",,Taylor and Francis Ltd.,20477724,,,32048560,English,Pathog. Global Health,Article,Article in Press,,Scopus,2-s2.0-85079410907,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Yethindra V.,57215715758;,Role of GS-5734 (Remdesivir) in inhibiting SARS-CoV and MERS-CoV: The expected role of GS-5734 (remdesivir) in COVID-19 (2019-nCoV)-VYTR hypothesis,2020,International Journal of Research in Pharmaceutical Sciences,11,Special Issue 1,,1,6,,,10.26452/ijrps.v11iSPL1.1973,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081732998&doi=10.26452%2fijrps.v11iSPL1.1973&partnerID=40&md5=8620deb1010c70751e0896ee075a21dc,"International School of Medicine, International University of Kyrgyzstan, 1F, Intergelpo street, Bishkek, 720054, Kyrgyzstan","Yethindra, V., International School of Medicine, International University of Kyrgyzstan, 1F, Intergelpo street, Bishkek, 720054, Kyrgyzstan","Coronaviruses (CoVs) are enveloped RNA viruses related to the family Coro-naviridae, the order Nirdovales, and observed in humans and other mammals. In December 2019, many pneumonia cases reported by patients with unknown causes, mainly associated with seafood and wet animal market in Wuhan, China, and where clinically resembled viral pneumonia. At present, there is no existence of antiviral drugs for the treatment of CoV infections. The results of our study are GS-5734 strongly inhibits SARS-CoV and MERS-CoV in HAE cells, GS-5734 inhibits CoVs at early stages in replication by inhibiting viral RNA synthesis, the absence of ExoN-mediated proofreading in viruses sensitive to treatment with GS-5734. Protease inhibitors can show improved outcomes in some coronaviruses, but mostly 99% of protease inhibitors bind to proteins present in the human body, and only 1% attacks on existed viruses. The expected role of GS-5734 (Remdesivir) in COVID-19 (2019-nCoV)-VYTR hypothesis explained. As broad-spectrum drugs are capable of inhibiting CoV infections, GS-5734 is a broad-spectrum drug and may show inhibition on CoV infections and COVID-19. GS-5734 will show desired results regarding antiviral activity against 2019-nCoV as it showed potent antiviral activity in other CoVs. More clinical trials and experiments needed to prove that GS-5734 (Remdesivir) is a potential and effective drug to treat COVID-19. © 2020 International Journal of Research in Pharmaceutical Sciences. All rights reserved.",2019-nCoV (2019 novel coronavirus); Anti-viral drugs; GS-5734; MERS-CoV; Remdesivir; SARS-CoV; VYTR hypothesis,fluorouracil; lopinavir; proteinase; remdesivir; ribavirin; virus RNA; 2019 novel coronavirus; airway epithelium cell; antiviral activity; antiviral resistance; antiviral susceptibility; Article; CC50 (cytotoxic concentration); cell viability; coronavirus disease 2019; cytotoxicity; exon; human; human cell; Human immunodeficiency virus; hypothesis; IC50; Middle East respiratory syndrome; Middle East respiratory syndrome coronavirus; Murine hepatitis virus; nonhuman; protein expression; real time polymerase chain reaction; SARS coronavirus; severe acute respiratory syndrome; viral plaque assay; virus inhibition; virus load; virus replication,"Cho, A., Zhang, L., Xu, J., Babusis, D., Butler, T., Lee, R., Kim, C.U., Synthesis and characterization of 2’-C-Me branched C-nucleosides as HCV poly-merase inhibitors (2012) Bioorganic & Medicinal Chemistry Letters, 22 (12), pp. 4127-4132; Fehr, A.R., Perlman, S., Coronaviruses: An Overview of Their Replication and Pathogenesis (2015) Coronaviruses: Methods and Protocols, Pages, pp. 1-23; Hui, D.S., Azhar, E., Madani, T.A., Ntoumi, F., Kock, R., Dar, O., Petersen, E., The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health-The latest 2019 novel coronavirus outbreak in Wuhan. China (2020) International Journal of Infectious Diseases, 91, pp. 264-266; Ksiazek, T.G., Erdman, D., Goldsmith, C.S., Zaki, S.R., Peret, T., Emery, S., Anderson, L.J., A Novel Coronavirus Associated with Severe Acute Respiratory Syndrome (2003) New England Journal of Medicine, 348 (20), pp. 1953-1966; Richman, D.D., Whitley, R.J., Hayden, F.G., (2016) Clinical Virology, , ASM Press. Washington; Sheahan, T.P., Sims, A.C., Graham, R.L., Menach-Ery, V.D., Gralinski, L.E., Case, J.B., Baric, R.S., Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses (2017) Science Translational Medicine, 9 (396); Sims, A.C., Baric, R.S., Yount, B., Burkett, S.E., Collins, P.L., Pickles, R.J., Severe Acute Respiratory Syndrome Coronavirus Infection of Human Ciliated Airway Epithelia: Role of Ciliated Cells in Viral Spread in the Conducting Airways of the Lungs (2005) Journal of Virology, 79 (24), pp. 15511-15524; Smith, E.C., Blanc, H., Vignuzzi, M., Denison, M.R., Coronaviruses Lacking Exoribonuclease Activity Are Susceptible to Lethal Mutagenesis: Evidence for Proofreading and Potential Therapeutics (2013) Plos Pathogens, 9 (8); Su, S., Wong, G., Shi, W., Liu, J., Lai, A.C.K., Zhou, J., Gao, G.F., Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses (2016) Trends in Microbiology, 24 (6), pp. 490-502; Warren, T.K., Wells, J., Panchal, R.G., Stuthman, K.S., Garza, N.L., Tongeren, S.A.V., Bavari, S., Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430 (2014) Nature, 508 (7496), pp. 402-405; (2019) Report of Clustering Pneumonia of Unknown Etiology in Wuhan City; Zaki, A.M., Boheemen, S.V., Bestebroer, T.M., Oster-Haus, A.D.M.E., Fouchier, R.A.M., Isolation of a Novel Coronavirus from a Man with Pneumonia in Saudi Arabia (2012) New England Journal of Medicine, 367 (19), pp. 1814-1820; Zhou, P., Yang, X.L., Wang, X.G., Hu, B., Zhang, L., Zhang, W., Shi, Z.L., (2020) Discovery of a Novel Coronavirus Associated with the Recent Pneumonia Outbreak in Humans and Its Potential Bat Origin; Zumla, A., Chan, J.F.W., Azhar, E.I., Hui, D.S.C., Yuen, K.Y., Coronaviruses-drug discovery and therapeutic options (2016) Nature Reviews. Drug Discovery, 15 (5), pp. 327-347","Yethindra, V.; International School of Medicine, International University of Kyrgyzstan, 1F, Intergelpo street, Kyrgyzstan",,J. K. Welfare and Pharmascope Foundation,9757538,,,,English,Int. J. Res. Pharm. Sci.,Article,Final,Open Access,Scopus,2-s2.0-85081732998,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Lu M., Liu Q., Wang X., Zhang J., Zhang X., Shi D., Liu J., Shi H., Chen J., Feng L.",57215556143;57214890434;56979423400;57192714108;55851450100;54399296900;55317283900;55233443300;8320190900;55792011500;,Development of an indirect ELISA for detecting porcine deltacoronavirus IgA antibodies,2020,Archives of Virology,,,,,,,,10.1007/s00705-020-04541-6,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079407980&doi=10.1007%2fs00705-020-04541-6&partnerID=40&md5=9a04b1eec681cbf672abf3927a3f958d,"Division of Swine Digestive System Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China","Lu, M., Division of Swine Digestive System Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China; Liu, Q., Division of Swine Digestive System Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China; Wang, X., Division of Swine Digestive System Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China; Zhang, J., Division of Swine Digestive System Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China; Zhang, X., Division of Swine Digestive System Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China; Shi, D., Division of Swine Digestive System Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China; Liu, J., Division of Swine Digestive System Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China; Shi, H., Division of Swine Digestive System Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China; Chen, J., Division of Swine Digestive System Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China; Feng, L., Division of Swine Digestive System Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China","Porcine deltacoronavirus (PDCoV) is a novel coronavirus that can cause vomiting and watery diarrhea in pigs and death in piglets. Since PDCoV was first detected in 2009 in Hong Kong, the prevalence of PDCoV has increased in recent years, resulting in serious economic losses to the swine industry. The coronavirus spike (S) protein is an antigen that has been demonstrated to contain epitopes that induce neutralizing antibodies. The presence of serum and milk IgA antibodies against pathogens that replicate primarily on mucosal surfaces is important for mucosal immunity. Here, an indirect anti-PDCoV IgA antibody enzyme-linked immunosorbent assay (PDCoV S1 IgA ELISA) using the purified S1 portion of S protein as the coating antigen was developed to detect PDCoV IgA antibodies in serum and sow’s milk. A receiver operating characteristic (ROC) curve analysis showed high specificity and sensitivity of the PDCoV-S1-IgA-ELISA based on samples confirmed by IFA. Anti-PDCoV IgA antibodies in 152 serum samples and 65 milk samples collected from six farms that had experienced diarrhea outbreaks within previous last two years were detected by this assay, and 62.5% of the serum samples and 100% of the milk samples were positive for PDCoV. The indirect ELISA method established in this study will provide a convenient tool for measurement of serum and milk IgA levels against PDCoV in pig herds, rapid detection of PDCoV infection in pigs, and evaluation of the immunogenicity of vaccines. © 2020, Springer-Verlag GmbH Austria, part of Springer Nature.",,,"Woo, P.C., Lau, S.K., Lam, C.S., Lau, C.C., Tsang, A.K., Lau, J.H., Bai, R., Yuen, K.Y., Discovery of seven novel Mammalian and avian coronaviruses in the genus deltacoronavirus supports bat coronaviruses as the gene source of alphacoronavirus and betacoronavirus and avian coronaviruses as the gene source of gammacoronavirus and deltacoronavirus (2012) J Virol, 86 (7), pp. 3995-4008. , COI: 1:CAS:528:DC%2BC38XktlOrsr8%3D; Chen, F., Zhu, Y., Wu, M., Ku, X., Yao, L., He, Q., Full-length genome characterization of chinese porcine deltacoronavirus strain CH/SXD1/2015 (2015) Genome Announc, 3 (5), p. 15; Li, G., Chen, Q., Harmon, K.M., Yoon, K.J., Schwartz, K.J., Hoogland, M.J., Gauger, P.C., Zhang, J., Full-length genome sequence of porcine deltacoronavirus strain USA/IA/2014/8734 (2014) Genome Announc, 2 (2), p. 14; Ma, Y., Zhang, Y., Liang, X., Lou, F., Oglesbee, M., Krakowka, S., Li, J., Origin, evolution, and virulence of porcine deltacoronaviruses in the United States (2015) mBio, 6 (2); Marthaler, D., Raymond, L., Jiang, Y., Collins, J., Rossow, K., Rovira, A., Rapid detection, complete genome sequencing, and phylogenetic analysis of porcine deltacoronavirus (2014) Emerg Infect Dis, 20 (8), pp. 1347-1350; Wang, Y.W., Yue, H., Fang, W., Huang, Y.W., Complete genome sequence of porcine deltacoronavirus strain CH/Sichuan/S27/2012 from Mainland China (2015) Genome Announc, 3 (5), p. 15; Janetanakit, T., Lumyai, M., Bunpapong, N., Boonyapisitsopa, S., Chaiyawong, S., Nonthabenjawan, N., Kesdaengsakonwut, S., Amonsin, A., Porcine deltacoronavirus, Thailand, 2015 (2016) Emerg Infect Dis, 22 (4), pp. 757-759. , COI: 1:CAS:528:DC%2BC2sXivVSrsLY%3D; Lee, S., Lee, C., Complete genome characterization of Korean porcine deltacoronavirus strain KOR/KNU14-04/2014 (2014) Genome Announc, 2 (6), p. 14; Lorsirigool, A., Saeng-Chuto, K., Temeeyasen, G., Madapong, A., Tripipat, T., Wegner, M., Tuntituvanont, A., Nilubol, D., The first detection and full-length genome sequence of porcine deltacoronavirus isolated in Lao PDR (2016) Adv Virol, 161 (10), pp. 2909-2911. , COI: 1:CAS:528:DC%2BC28XhtFyiu7rI; Song, D., Zhou, X., Peng, Q., Chen, Y., Zhang, F., Huang, T., Zhang, T., Tang, Y., Newly emerged porcine deltacoronavirus associated with diarrhoea in swine in China: identification, prevalence and full-length genome sequence analysis (2015) Transbound Emerg Dis, 62 (6), pp. 575-580. , COI: 1:CAS:528:DC%2BC2MXhslKltr7M; Zhai, S.L., Wei, W.K., Li, X.P., Wen, X.H., Zhou, X., Zhang, H., Lv, D.H., Wang, D., Occurrence and sequence analysis of porcine deltacoronaviruses in southern China (2016) Virol J, 13, p. 136; Chen, J., Wang, X., Jiao, H., Shi, H., Zhang, X., Liu, J., Shi, D., Feng, L., Isolation and identification of the first porcine deltacoronavirus strain in China (2016) Chin J Prev Vet Med, 38 (3), pp. 171-174; Zhang, J., Porcine deltacoronavirus: overview of infection dynamics, diagnostic methods, prevalence and genetic evolution (2016) Virus Res, 226, pp. 71-84. , COI: 1:CAS:528:DC%2BC28XhtVWks73M; Chiou, H.Y., Huang, Y.L., Deng, M.C., Chang, C.Y., Jeng, C.R., Tsai, P.S., Yang, C., Chang, H.W., Phylogenetic analysis of the spike (S) gene of the new variants of porcine epidemic diarrhoea virus in Taiwan (2017) Transbound Emerg Dis, 64 (1), pp. 157-166. , COI: 1:CAS:528:DC%2BC2sXms12ruw%3D%3D; Beniac, D.R., Andonov, A., Grudeski, E., Booth, T.F., Architecture of the SARS coronavirus prefusion spike (2006) Nat Struct Mol Biol, 13 (8), pp. 751-752. , COI: 1:CAS:528:DC%2BD28Xnsl2jt70%3D; Abraham, S., Kienzle, T.E., Lapps, W., Brian, D.A., Deduced sequence of the bovine coronavirus spike protein and identification of the internal proteolytic cleavage site (1990) Virology, 176 (1), pp. 296-301. , COI: 1:CAS:528:DyaK3cXkslajsr8%3D; Delmas, B., Laude, H., Assembly of coronavirus spike protein into trimers and its role in epitope expression (1990) J Virol, 64 (11), pp. 5367-5375. , COI: 1:CAS:528:DyaK3cXmt1Oktrg%3D; Luytjes, W., Sturman, L.S., Bredenbeek, P.J., Charite, J., van der Zeijst, B.A., Horzinek, M.C., Spaan, W.J., Primary structure of the glycoprotein E2 of coronavirus MHV-A59 and identification of the trypsin cleavage site (1987) Virology, 161 (2), pp. 479-487. , COI: 1:CAS:528:DyaL1cXktFyqu7o%3D; Knuchel, M., Ackermann, M., Muller, H.K., Kihm, U., An ELISA for detection of antibodies against porcine epidemic diarrhoea virus (PEDV) based on the specific solubility of the viral surface glycoprotein (1992) Vet Microbiol, 32 (2), pp. 117-134. , COI: 1:CAS:528:DyaK38XmtFShtLc%3D; Simkins, R.A., Weilnau, P.A., Van Cott, J., Brim, T.A., Saif, L.J., Competition ELISA, using monoclonal antibodies to the transmissible gastroenteritis virus (TGEV) S protein, for serologic differentiation of pigs infected with TGEV or porcine respiratory coronavirus (1993) Am J Vet Res, 54 (2), pp. 254-259. , COI: 1:CAS:528:DyaK3sXhs1CmurY%3D, PID: 8381626; Elia, G., Decaro, N., Martella, V., Lorusso, E., Mari, V., Maria, S.L., Cordioli, P., Buonavoglia, C., An ELISA based on recombinant spike protein S for the detection of antibodies to transmissible gastroenteritis virus of swine-like canine coronaviruses (2010) J Virol Methods, 163 (2), pp. 309-312. , COI: 1:CAS:528:DC%2BC3cXjtlemuw%3D%3D; Ma, Y., Zhang, Y., Liang, X., Oglesbee, M., Krakowka, S., Niehaus, A., Wang, G., Li, J., Two-way antigenic cross-reactivity between porcine epidemic diarrhea virus and porcine deltacoronavirus (2016) Vet Microbiol, 186, pp. 90-96. , COI: 1:CAS:528:DC%2BC28XjsFKgurw%3D; Su, M., Li, C., Guo, D., Wei, S., Wang, X., Geng, Y., Yao, S., Sun, D., A recombinant nucleocapsid protein-based indirect enzyme-linked immunosorbent assay to detect antibodies against porcine deltacoronavirus (2016) J Vet Med Sci, 78 (4), pp. 601-606. , COI: 1:CAS:528:DC%2BC2sXjtFOqsrw%3D; Thachil, A., Gerber, P.F., Xiao, C.T., Huang, Y.W., Opriessnig, T., Development and application of an ELISA for the detection of porcine deltacoronavirus IgG antibodies (2015) PLoS One, 10 (4); Saif, L.J., van Cott, J.L., Brim, T.A., Immunity to transmissible gastroenteritis virus and porcine respiratory coronavirus infections in swine (1994) Vet Immunol Immunopathol, 43 (1-3), pp. 89-97. , COI: 1:STN:280:DyaK2M7lvFCjtw%3D%3D; Saif, L.J., Mucosal immunity: an overview and studies of enteric and respiratory coronavirus infections in a swine model of enteric disease (1996) Vet Immunol Immunopathol, 54 (1-4), pp. 163-169. , COI: 1:CAS:528:DyaK2sXnt1OmsA%3D%3D; To, T.L., Ward, L.A., Yuan, L., Saif, L.J., Serum and intestinal isotype antibody responses and correlates of protective immunity to human rotavirus in a gnotobiotic pig model of disease (1998) J Gen Virol, 79 (11), pp. 2661-2672. , COI: 1:CAS:528:DyaK1cXmvFyqsbk%3D; Hu, H., Jung, K., Vlasova, A.N., Saif, L.J., Experimental infection of gnotobiotic pigs with the cell-culture-adapted porcine deltacoronavirus strain OH-FD22 (2016) Adv Virol, 161 (12), pp. 3421-3434. , COI: 1:CAS:528:DC%2BC28XhsV2rtLnP; de Arriba, M.L., Carvajal, A., Pozo, J., Rubio, P., Mucosal and systemic isotype-specific antibody responses and protection in conventional pigs exposed to virulent or attenuated porcine epidemic diarrhoea virus (2002) Vet Immunol Immunopathol, 85 (1-2), pp. 85-97; Salmon, H., Mammary gland immunology and neonate protection in pigs. Homing of lymphocytes into the MG (2000) Adv Exp Med Biol, 480, pp. 279-286. , COI: 1:CAS:528:DC%2BD38XntFSmsb0%3D","Chen, J.; Division of Swine Digestive System Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural SciencesChina; email: chenjianfei@caas.cn",,Springer,3048608,,ARVID,,English,Arch. Virol.,Article,Article in Press,Open Access,Scopus,2-s2.0-85079407980,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Degnah A.A., Al-amri S.S., Hassan A.M., Almasoud A.S., Mousa M., Almahboub S.A., Alhabbab R.Y., Mirza A.A., Hindawi S.I., Alharbi N.K., Azhar E.I., Hashem A.M.",57212143805;56136290100;7402686960;57211276540;57212151403;57214225176;53863098400;7101802887;23473286600;55266214200;23090055800;57200589744;,"Seroprevalence of MERS-CoV in healthy adults in western Saudi Arabia, 2011–2016",2020,Journal of Infection and Public Health,,,,,,,,10.1016/j.jiph.2020.01.001,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078452160&doi=10.1016%2fj.jiph.2020.01.001&partnerID=40&md5=8084e4d92b5ab08abda1d8bb8ee5d62d,"Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia; Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Infectious Disease Research, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; Department of Medical Microbiology and Parasitology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Hematology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia; King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia","Degnah, A.A., Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia, Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia; Al-amri, S.S., Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia; Hassan, A.M., Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia; Almasoud, A.S., Department of Infectious Disease Research, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; Mousa, M., Department of Medical Microbiology and Parasitology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia; Almahboub, S.A., Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia; Alhabbab, R.Y., Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia; Mirza, A.A., Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia; Hindawi, S.I., Department of Hematology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia; Alharbi, N.K., Department of Infectious Disease Research, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; Azhar, E.I., Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia, Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia; Hashem, A.M., Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia, Department of Medical Microbiology and Parasitology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia","Background: The Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly recognized zoonotic coronavirus. Current evidence confirms the role of dromedaries in primary human infections but does not explain the sporadic community cases. However, asymptomatic or subclinical cases could represent a possible source of infection in the community. Methods: Archived human sera (7461) collected between 2011 and 2016 from healthy adult blood donors from 50 different nationalities in the western part of Saudi Arabia were obtained for MERS-CoV seroprevalence investigation. Samples were tested for MERS-CoV S1-specific antibodies (Abs) by ELISA and confirmed by testing for neutralizing Abs (nAbs) using both pseudotyped and live virus neutralization assays. Results: Out of 7461 samples, 174 sera from individuals with 18 different nationalities were ELISA positive (2.3%, 95% CI 2.0–2.7). Presence of nAbs was confirmed in 17 samples (0.23%, 95% CI 0.1–0.4) of which one sample exhibited positivity in both neutralization assays. Confirmed seropositivity was identified in young (15–44 years) men and women from Saudi Arabia, Egypt, Yemen, Pakistan, Palestine, Sudan, and India without significant preference. Conclusions: An increasing trend of MERS-CoV seroprevalence was observed in the general population in western Saudi Arabia, suggesting that asymptomatic or mild infections might exist and act as an unrecognized source of infection. Seropositivity of individuals from different nationalities underscores the potential MERS exportation outside of the Arabian Peninsula. Thus, enhanced and continuous surveillance is highly warranted. © 2020",Blood donors; MERS-CoV; Saudi Arabia; Seroprevalence,,"Zaki, A.M., van Boheemen, S., Bestebroer, T.M., Osterhaus, A.D., Fouchier, R.A., Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia (2012) N Engl J Med, 367, pp. 1814-1820; Al-Abdallat, M.M., Payne, D.C., Alqasrawi, S., Rha, B., Tohme, R.A., Abedi, G.R., Hospital-associated outbreak of Middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description (2014) Clin Infect Dis, 59, pp. 1225-1233; Assiri, A., Al-Tawfiq, J.A., Al-Rabeeah, A.A., Al-Rabiah, F.A., Al-Hajjar, S., Al-Barrak, A., Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study (2013) Lancet Infect Dis, 13, pp. 752-761; Song, Y.J., Yang, J.S., Yoon, H.J., Nam, H.S., Lee, S.Y., Cheong, H.K., Asymptomatic Middle East respiratory syndrome coronavirus infection using a serologic survey in Korea (2018) Epidemiol Health, 40, p. e2018014; Müller, M.A., Meyer, B., Corman, V.M., Al-Masri, M., Turkestani, A., Ritz, D., Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, cross-sectional, serological study (2015) Lancet Infect Dis, 15, pp. 559-564; Al Hammadi, Z.M., Chu, D.K., Eltahir, Y.M., Al Hosani, F., Al Mulla, M., Tarnini, W., Asymptomatic MERS-CoV infection in humans possibly linked to infected dromedaries imported from Oman to United Arab Emirates, May 2015 (2015) Emerg Infect Dis, 21, pp. 2197-2200; Alagaili, A.N., Briese, T., Mishra, N., Kapoor, V., Sameroff, S.C., Burbelo, P.D., Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia (2014) mBio, 5, pp. e00884-14; Miguel, E., Chevalier, V., Ayelet, G., Ben Bencheikh, M.N., Boussini, H., Chu, D.K., Risk factors for MERS coronavirus infection in dromedary camels in Burkina Faso, Ethiopia, and Morocco, 2015 (2017) Euro Surveill, 22, p. 30498; Reusken, C.B., Ababneh, M., Raj, V.S., Meyer, B., Eljarah, A., Abutarbush, S., Middle east respiratory syndrome coronavirus (MERS-CoV) serology in major livestock species in an affected region in Jordan, June to September 2013 (2013) Euro Surveill, 18, p. 20662; Munyua, P., Corman, V.M., Bitek, A., Osoro, E., Meyer, B., Müller, M.A., No serologic evidence of Middle East respiratory syndrome coronavirus infection among camel farmers exposed to highly seropositive camel herds: a household linked study, Kenya, 2013 (2017) Am J Trop Med Hyg, 96, pp. 1318-1324; Ommeh, S., Zhang, W., Zohaib, A., Chen, J., Zhang, H., Hu, B., Genetic evidence of Middle East respiratory syndrome coronavirus (MERS-Cov) and widespread seroprevalence among camels in Kenya (2018) Virol Sin, 33, pp. 484-492; Zohaib, A., Saqib, M., Athar, M.A., Chen, J., Sial, A.U., Khan, S., Countrywide survey for MERS-coronavirus antibodies in dromedaries and humans in Pakistan (2018) Virol Sin, 33, pp. 410-417; So, R.T., Perera, R.A., Oladipo, J.O., Chu, D.K., Kuranga, S.A., Chan, K.H., Lack of serological evidence of Middle East respiratory syndrome coronavirus infection in virus exposed camel abattoir workers in Nigeria, 2016 (2018) Euro Surveill, 23 (32); Chu, D.K., Poon, L.L., Gomaa, M.M., Shehata, M.M., Perera, R.A., Abu Zeid, D., MERS coronaviruses in dromedary camels, Egypt (2014) Emerg Infect Dis, 20, pp. 1049-1053; Hemida, M.G., Al-Naeem, A., Perera, R.A.P.M., Chin, A.W.H., Poon, L.L.M., Peiris, M., Lack of Middle East respiratory syndrome coronavirus transmission from infected camels (2015) Emerg Infect Dis, 21, pp. 699-701; Perera, R.A., Wang, P., Gomaa, M.R., El-Shesheny, R., Kandeil, A., Bagato, O., Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt, June 2013 (2013) Euro Surveill, 18, p. 20574; Kandeil, A., Gomaa, M., Shehata, M., El-Taweel, A., Kayed, A.E., Abiadh, A., Middle East respiratory syndrome coronavirus infection in non-camelid domestic mammals (2019) Emerg Microbes Infect, 8, pp. 103-108; Breban, R., Riou, J., Fontanet, A., Interhuman transmissibility of Middle East respiratory syndrome coronavirus: estimation of pandemic risk (2013) Lancet, 382, pp. 694-699; Cauchemez, S., Fraser, C., Van Kerkhove, M.D., Donnelly, C.A., Riley, S., Rambaut, A., Middle East respiratory syndrome coronavirus: quantification of the extent of the epidemic, surveillance biases, and transmissibility (2014) Lancet Infect Dis, 14, pp. 50-56; World Health Organization, https://www.who.int/emergencies/mers-cov/en/, Middle East respiratory syndrome coronavirus (MERS-CoV). [Accessed 28 December 2019]; Zhao, J., Alshukairi, A.N., Baharoon, S.A., Ahmed, W.A., Bokhari, A.A., Nehdi, A.M., Recovery from the Middle East respiratory syndrome is associated with antibody and T-cell responses (2017) Sci Immunol, 2; Alshukairi, A.N., Zheng, J., Zhao, J., Nehdi, A., Baharoon, S.A., Layqah, L., High prevalence of MERS-CoV infection in camel workers in Saudi Arabia (2018) mBio, 9, pp. e01985-18; Kim, C.J., Choi, W.S., Jung, Y., Kiem, S., Seol, H.Y., Woo, H.J., Surveillance of the Middle East respiratory syndrome (MERS) coronavirus (CoV) infection in healthcare workers after contact with confirmed MERS patients: incidence and risk factors of MERS-CoV seropositivity (2016) Clin Microbiol Infect, 22, pp. 880-886; Khudhair, A., Killerby, M.E., Al Mulla, M., Abou Elkheir, K., Ternanni, W., Bandar, Z., Risk factors for MERS-CoV seropositivity among animal market and slaughterhouse workers, Abu Dhabi, United Arab Emirates, 2014-2017 (2019) Emerg Infect Dis, 25, pp. 927-935; Reusken, C.B., Farag, E.A., Haagmans, B.L., Mohran, K.A., Godeke, G.J., 5th, Raj, S., Occupational exposure to dromedaries and risk for MERS-CoV infection, Qatar, 2013-2014 (2015) Emerg Infect Dis, 21, pp. 1422-1425; Gierer, S., Hofmann-Winkler, H., Albuali, W.H., Bertram, S., Al-Rubaish, A.M., Yousef, A.A., Lack of MERS coronavirus neutralizing antibodies in humans, Eastern province, Saudi Arabia (2013) Emerg Infect Dis, 19, pp. 2034-2036; Aburizaiza, A.S., Mattes, F.M., Azhar, E.I., Hassan, A.M., Memish, Z.A., Muth, D., Investigation of anti- Middle East respiratory syndrome antibodies in blood donors and slaughterhouse workers in Jeddah and Makkah, Saudi Arabia, Fall 2012 (2014) J Infect Dis, 209, pp. 243-246; Memish, Z.A., Alsahly, A., Masri, M.A., Heil, G.L., Anderson, B.D., Peiris, M., Sparse evidence of MERS-CoV infection among animal workers living in Southern Saudi Arabia during 2012 (2015) Influenza Other Respir Viruses, 9, pp. 64-67; Al Kahlout, R.A., Nasrallah, G.K., Farag, E.A., Wang, L., Lattwein, E., Müller, M.A., Comparative serological study for the prevalence of anti-MERS coronavirus antibodies in high- and low-risk groups in Qatar (2019) J Immunol Res, 2019; Liljander, A., Meyer, B., Jores, J., Müller, M.A., Lattwein, E., Njeru, I., MERS-CoV antibodies in humans, Africa, 2013-2014 (2016) Emerg Infect Dis, 22, pp. 1086-1089; Hashem, A.M., Al-Amri, S.S., Al-Subhi, T.L., Siddiq, L.A., Hassan, A.M., Alawi, M.M., Development and validation of different indirect ELISAs for MERS-CoV serological testing (2019) J Immunol Methods, 466, pp. 41-46; Grehan, K., Ferrara, F., Temperton, N., An optimised method for the production of MERS-CoV spike expressing viral pseudotypes (2015) MethodsX, 2, pp. 379-384; Hemida, M.G., Perera, R.A., Al Jassim, R.A., Kayali, G., Siu, L.Y., Wang, P., Seroepidemiology of Middle East respiratory syndrome (MERS) coronavirus in Saudi Arabia (1993) and Australia (2014) and characterisation of assay specificity (2014) Euro Surveill, 19, p. 20828; Park, S.W., Perera, R.A., Choe, P.G., Lau, E.H., Choi, S.J., Chun, J.Y., Comparison of serological assays in human Middle East respiratory syndrome (MERS)-coronavirus infection (2015) Euro Surveill, 20, p. 30042","Hashem, A.M.; Faculty of Medicine and King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 80205, Saudi Arabia; email: amhashem@kau.edu.sa",,Elsevier Ltd,18760341,,,,English,J. Infect. Public Health,Article,Article in Press,Open Access,Scopus,2-s2.0-85078452160,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Gravinatti M.L., Barbosa C.M., Soares R.M., Gregori F.",56009931500;57194183106;7101994529;14064950700;,Synanthropic rodents as virus reservoirs and transmitters,2020,Revista da Sociedade Brasileira de Medicina Tropical,53,, e20190486,,,,,10.1590/0037-8682-0486-2019,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079338599&doi=10.1590%2f0037-8682-0486-2019&partnerID=40&md5=7556efd89a3419a3e2cd385fe47db162,"Departamento de Medicina Veterinária Preventiva e Saúde Animal, Faculdade de Medicina Veterinária, Universidade de São Paulo, São Paulo, SP, Brazil; Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP, Brazil","Gravinatti, M.L., Departamento de Medicina Veterinária Preventiva e Saúde Animal, Faculdade de Medicina Veterinária, Universidade de São Paulo, São Paulo, SP, Brazil; Barbosa, C.M., Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, SP, Brazil; Soares, R.M., Departamento de Medicina Veterinária Preventiva e Saúde Animal, Faculdade de Medicina Veterinária, Universidade de São Paulo, São Paulo, SP, Brazil; Gregori, F., Departamento de Medicina Veterinária Preventiva e Saúde Animal, Faculdade de Medicina Veterinária, Universidade de São Paulo, São Paulo, SP, Brazil","This review focuses on reports of hepatitis E virus, hantavirus, rotavirus, coronavirus, and arenavirus in synanthropic rodents (Rattus rattus, Rattus norvegicus, and Mus musculus) within urban environments. Despite their potential impact on human health, relatively few studies have addressed the monitoring of these viruses in rodents. Comprehensive control and preventive activities should include actions such as the elimination or reduction of rat and mouse populations, sanitary education, reduction of shelters for the animals, and restriction of the access of rodents to residences, water, and food supplies. © 2020, Sociedade Brasileira de Medicina Tropical. All rights reserved.",One health; Rat; Urban environment; Viruses,Arenaviridae; Coronavirinae; disease control; enzyme linked immunosorbent assay; Hantavirus; hepatitis E; Hepatitis E virus; immunofluorescence test; metagenomics; mortality rate; nonhuman; open reading frame; phylogeny; prevalence; prophylaxis; Review; Rotavirus; survival rate; urban area; viral clearance; virus detection; virus replication; virus transmission; virus virulence; animal; arenavirus infection; Coronavirus infection; disease carrier; Hantavirus infection; hepatitis E; mouse; rat; Rotavirus infection; urban population; virology; Animals; Arenaviridae Infections; Coronavirus Infections; Disease Reservoirs; Hantavirus Infections; Hepatitis E; Mice; Rats; Rotavirus Infections; Urban Population,"",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, iomeningitis linfocítica (Arenavirus) en roedores Mus musculus capturados en la zona urbana del municipio de Sincelejo, Sucre (2017) Colombia. Biomédica, 37 (1), pp. 75-85; Lavergne, A., de Thoisy, B., Tirera, S., Donato, D., Bouchier, C., Catzeflis, F., Identification of lymphocytic choriomeningitis mammarenavirus in house mouse (Mus musculus, Rodentia) in French Guiana (2016) Infect Genet Evol,37, pp. 225-230; Riera, L., Castillo, E., Del Carmen Saavedra, M., Priotto, J., Sottosanti, J., Polop, J., Serological study of the lymphochoriomeningitis virus (LCMV) in an inner city of Argentina (2005) J Med Virol, 76 (2), pp. 285-289; Childs, J.E., Glass, G.E., Korch, G.W., Ksiazek, T.G., Leduc, J.W., Lymphocytic choriomeningitis virus infection and house mouse (Mus musculus) distribution in urban Baltimore (1992) Am J Trop Med Hyg, 47 (1), pp. 27-34; Childs, J.E., Glass, G.E., Ksiazek, T.G., Rossi, C.A., Oro, J.G., Leduc, J.W., Human-rodent contact and infection with lymphocytic choriomeningitis and Seoul viruses in an inner-city population (1991) Am J Trop Med Hyg, 44 (2), pp. 117-121; (2019) Lassa Virus (CDC), , https://www.cdc.gov/vhf/lassa/index.html; Richmond, J.K., Baglole, D.J., Lassa fever: Epidemiology, clinical features, and social consequences (2003) BMJ, 327 (7426), pp. 1271-1275; Olayemi, A., Cadar, D., Magassouba, N., Obadare, A., Kourouma, F., Oyeyiola, A., New hosts of The Lassa virus (2016) Scirep, 6; Olayemi, A., Oyeyiola, A., Obadare, A., Igbokwe, J., Adesina, A.S., Onwe, F., Widespread arenavirus occurrence and seroprevalence in small mammals, Nigeria (2018) Parasit Vectors, 11 (1); Agbonlahor, D.E., Erah, A., Agba, I.M., Oviasogie, F.E., Ehiaghe, A.F., Wankasi, M., Prevalence of Lassa virus among rodents trapped in three South-South States of Nigeria (2017) J Vector Borne Dis, 54 (2), pp. 146-150; Mills, J.N., Ellis, B.A., Childs, J.E., McKee, K.T., Jr., Maiztegui, J.I., Peters, C.J., Prevalence of infection with Junin virus in rodent populations in the epidemic area of Argentine hemorrhagic fever (1994) Am J Trop Med Hygiene, 51 (5), pp. 554-562; Enria, D.A., Briggiler, A.M., Sanchez, Z., Treatment of Argentine hemorrhagic fever (2008) Antivir Res, 78 (1), pp. 132-139; Salami, K., Gouglas, D., Schmaljohn, C., Saville, M., Tornieporth, N., A review of Lassa fever vaccine candidates (2019) Curr Opin Virol,37, pp. 105-111; Cashman, K.A., Wilkinson, E.R., Shaia, C.I., Facemire, P.R., Bell, T.M., Bearss, J.J., A DNA vaccine delivered by dermal electroporation fully protects cynomolgus macaques against Lassa fever (2017) Hum Vaccin Immunother, 13 (12), pp. 2902-2911; Gonzalez, J.P., Bowen, M.D., Nichol, S.T., Rico-Hesse, R., Genetic characterization and phylogeny of Sabiá virus, an emergent pathogen in Brazil (1996) Virology, 221 (2), pp. 318-324; Vasconcelos, P.F.C., Travassos da Rosa, A.P.A., Rodrigues, S.G., Tesh, R.B., Travassos da Rosa, J.F.S., Travassos da Rosa, E.S., Infecção humana adquirida em laboratório causada pelo vírus SP H 114202 (Arenavirus: Família Arenaviridae)-Aspectos clínicos e laboratoriais (1993) Rev Inst Med Trop São Paulo, 35 (6), pp. 521-525; Arenavirus infection-Connecticut (1994) MMWR Morb Mortal Wkly Rep, 43 (34), pp. 635-636; Ellwanger, J.H., Chies, J.A.B., Keeping track of hidden dangers-The short history of the Sabiá virus (2017) Rev Soc Bras Med Trop, 50 (1), pp. 3-8; (2020) Boletim epidemiológico-Secretaria De Vigilância Em Saúde, 51 (3). , http://portalarquivos2.saude.gov.br/images/pdf/2020/janeiro/20/Boletim-epidemiologico-SVS-03.pdf, Identificação de um caso de febre hemorrágica brasileira no estado de São Paulo, janeiro de 2020, [update 2020 Jan 20; cited 2020 Jan 21]. Available from; Bisordi, I., Levis, S., Maeda, A.Y., Suzuki, A., Nagasse-Sugahara, T.K., de Souza, R.P., Pinhal Virus, a New Arenavirus Isolated from Calomys tener in Brazil (2015) Vector Borne Zoonotic Dis, 15 (11), pp. 694-700; Fernandes, J., Guterres, A., de Oliveira, R.C., Jardim, R., Dávila, A.M.R., Hewson, R., Aporé virus, a novel mammarenavirus (Bunyavirales: Arenaviridae) related to highly pathogenic virus from South America (2019) Mem Inst Oswaldo Cruz, 114; Barry, M., Russi, M., Armstrong, L., Geller, D.L., Tesh, R., Dembry, L., Treatment of laboratory-acquired Sabiá vírus infection (1995) N Engl J Med, 333 (5), pp. 294-296; Kochhar, D.M., Penner, J.D., Knudsen, T.B., Embryotoxic, teratogenic, and metabolic effects of ribavirin in mice (1980) Toxicol Appl Pharmacol, 52 (1), pp. 99-112; Westover, J.B., Sefing, E.J., Bailey, K.W., Wettere, A.J., Jung, K.-H., Dagley, A., Low-dose ribavirin potentiates the antiviral activity of favipiravir against hemorrhagic fever viroses (2016) Antiviral Res,126, pp. 62-68; Torriani, G., Trofimenko, E., Mayor, J., Fedeli, C., Moreno, H., Michel, S., Identification of Clotrimazole Derivatives as Specific Inhibitors of Arenavirus Fusion (2019) J Virol, 93 (6), pp. e01744-18; Lee, A.M., Rojek, J.M., Spiropoulou, C.F., Gundersen, A.T., Jin, W., Shaginian, A., Unique small molecule entry inhibitors of hemorrhagic fever arenaviruses (2008) J Biol Chem, 283 (27)," pp. 18734-18742""","Gravinatti, M.L.; Departamento de Medicina Veterinária Preventiva e Saúde Animal, Faculdade de Medicina Veterinária, Universidade de São PauloBrazil; email: maralgravinatti@gmail.com",,Sociedade Brasileira de Medicina Tropical,378682,,RSBTB,32049206,English,Rev. Soc. Bras. Med. Trop.,Review,Final,Open Access,Scopus,2-s2.0-85079338599,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Han X., Fan Y., Wan Y.-L., Shi H.",57208739929;57215840000;57211309919;12789169600;,A Diabetic Patient with 2019-nCoV Infection Who Recovered and Was Discharged from Hospital,2020,Journal of Thoracic Imaging,,,,,,,,10.1097/RTI.0000000000000506,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082045077&doi=10.1097%2fRTI.0000000000000506&partnerID=40&md5=1547c4aabc1d62cdd9e913fa25da485e,"Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan Jinyintan Hospital, Wuhan City, Hubei Province, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan Jinyintan Hospital, Wuhan City, Hubei Province, China; Department of Radiology, Wuhan Jinyintan Hospital, Wuhan City, Hubei Province, China; Department of Medical Imaging and Intervention, Linkou Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan City, Taiwan","Han, X., Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan Jinyintan Hospital, Wuhan City, Hubei Province, China, Hubei Province Key Laboratory of Molecular Imaging, Wuhan Jinyintan Hospital, Wuhan City, Hubei Province, China; Fan, Y., Department of Radiology, Wuhan Jinyintan Hospital, Wuhan City, Hubei Province, China; Wan, Y.-L., Department of Medical Imaging and Intervention, Linkou Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan City, Taiwan; Shi, H., Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan Jinyintan Hospital, Wuhan City, Hubei Province, China","Novel coronavirus has become a global health hazard and its high infectivity is alarming. The imaging findings of the 2019-nCoV infection in our young diabetic patient featured ground-glass opacities and consolidations in both lungs. The lung lesions may involute rapidly during the course. The patient showed improvement both clinically and on computed tomography imaging at discharged after 2 weeks'treatment. Computed tomography scans of patients helped monitor the changes continuously, which could timely provide the information of the evolution of the disease or therapeutic effect to clinicians. © 2020 Lippincott Williams and Wilkins. All rights reserved.",2019-nCoV; computed tomography; emerging diseases; viral pneumonia,,"(2020), www.who.int/csr/don/12-january-2020-novel-coronavirus-china/en, World Health Organization (WHO)-Novel Coronavirus-China. Accessed February 12, 2020; World Health Organization (WHO). WHO/Novel Coronavirus. China: World Health Organization (WHO); 2020; (2020), www.who.int/emergencies/diseases/novelcoronavirus2019, World Health Organization (WHO). Novel coronavirus-Thailand (ex-China) . Accessed February 15, 2020; (2020), www.who.int/csr/don/17-january-2020-novel-coronavirusjapan-ex-china/en/, World Health Organization (WHO). Novel coronavirus-Japan (ex-China) . Accessed January 19, 2020; (2020), www.who.int/csr/don/21-january-2020-novelcoronavirus-republic-of-koreaex-china/en/, World Health Organization (WHO). Novel coronavirus-Republic of Korea (ex-China) . Accessed January 23, 2020; (2020) Clinical Management of Severe Acute Respiratory Infection When Novel Coronavirus (NCoV) Infection Is Suspected: Interim Guidance, , World Health Organization (WHO) . WHO/ nCoV/Clinical/2020.1; Na, Z., Ding, Z., Wen, W., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, , Epub ahead of print; Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med., 382, pp. 727-733; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study (2020) Lancet., 395, pp. 507-513","Shi, H.; Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyChina; email: heshuishi@hust.edu.cn",,Lippincott Williams and Wilkins,8835993,,JTIME,32168162,English,J. Thorac. Imaging,Article,Article in Press,Open Access,Scopus,2-s2.0-85082045077,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Park O., Park Y.J., Park S.Y., Kim Y.-M., Kim J., Lee J., Park E., Kim D., Jeon B.-H., Ryu B., Ko D., Kim E., Kim H., Lee H., Gwack J., Jo J., Lee J.H., Hyun J., Kim J., Park J.K., Lee S., Kim S.S., Shin S.H., Choi S.W., Kim T., Kim U.-N., Woo Y., Jin Y., Jang Y.S., Park Y., Yum M.",35077985800;57215675940;57216094460;57189320800;57201935846;57215676085;57215655806;56683267900;57215672539;57215673722;57215663590;57215653173;57215661973;57192500755;23134705500;57215650293;57215676089;57215664217;57215675930;57215661934;57215663699;57215675965;57215666914;57215652122;57215651037;57201728168;57215655960;57215653993;57215667186;55494473600;57215673768;,Contact transmission of Covid-19 in South Korea: Novel investigation techniques for tracing contacts,2020,Osong Public Health and Research Perspectives,,1,,60,63,,2,10.24171/j.phrp.2020.11.1.09,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081608728&doi=10.24171%2fj.phrp.2020.11.1.09&partnerID=40&md5=5d3ad519e9dccd17623d7f4fec6c74a7,,"Park, O.; Park, Y.J.; Park, S.Y.; Kim, Y.-M.; Kim, J.; Lee, J.; Park, E.; Kim, D.; Jeon, B.-H.; Ryu, B.; Ko, D.; Kim, E.; Kim, H.; Lee, H.; Gwack, J.; Jo, J.; Lee, J.H.; Hyun, J.; Kim, J.; Park, J.K.; Lee, S.; Kim, S.S.; Shin, S.H.; Choi, S.W.; Kim, T.; Kim, U.-N.; Woo, Y.; Jin, Y.; Jang, Y.S.; Park, Y.; Yum, M.","In the epidemiological investigation of an infectious disease, investigating, classifying, tracking, and managing contacts by identifying the patient’s route are important for preventing further transmission of the disease. However, omissions and errors in previous activities can occur when the investigation is performed through only a proxy interview with the patient. To overcome these limitations, methods that can objectively verify the patient’s claims (medical facility records, Global Positioning System, card transactions, and closed-circuit television) were used for the recent ongoing coronavirus disease 2019 contact investigations in South Korea. © 2020 Korea Centers for Disease Control and Prevention.",2019 novel coronavirus infection; Contact tracing; Global positioning system; Infectious disease; Medical records,2019 novel coronavirus; Article; case management; contact examination; Coronavirinae; Coronavirus infection; credit card transaction log; disease control; exposure; global positioning system; human; infection prevention; information processing; interview; medical record; patient identification; priority journal; proxy; risk assessment; South Korea; virus transmission,"Thacker, S.B., Stroup, D.F., Sencer, D.J., Epidemic assistance by the Centers for Disease Control and Prevention: Role of the epidemic intelligence service, 1946-2005 (2011) Am J Epidemiol, 174 (11), pp. S4-S15; (2015) Infection Prevention and Control Recommendations for Hospitalized Patients with Middle East Respiratory Syndrome Coronavirus (MERS-CoV), , http://www.cdc.gov/coronavirus/mers/infectionprevention-control.html, Internet. Atlanta (GA): Centers for Disease Control and Prevention; cited 2015 Jul 27; (2015) Infection Prevention and Control of Epidemic and Pandemic Prone 21 Acute Respiratory Infections in Health Care: WHO Guidelines, , http://www.who.int/csr/bioriskreduction/infection_control/publication/en/, Internet. Geneva (Switzerland): World Health Organization; cited 2015 Jul 5; (2020) COVID-19 Response and Management Guidelines, , Korea Centers for Disease Control and Prevention. 3rd ed. Cheongju (Korea): Korea Centers for Disease Control and Prevention","Park, O.email: okpark8932@gmail.com",,Korea Centers for Disease Control and Prevention,22109099,,,,English,Osong Public Health Res. Perspect.,Article,Final,Open Access,Scopus,2-s2.0-85081608728,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhang Y., Han L., Xia L., Yuan Y., Hu H.",57207479622;57213672027;57213672502;57213672749;56555521500;,Assessment of hemagglutination activity of porcine deltacoronavirus,2020,Journal of Veterinary Science,21,1, e12,,,,,10.4142/jvs.2020.21.e12,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077940988&doi=10.4142%2fjvs.2020.21.e12&partnerID=40&md5=0a7d5dcaf934bf6f7ac2cd1e007d04ab,"College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450002, China; Key Laboratory for Animal-derived Food Safety of Henan Province, Zhengzhou, 450002, China","Zhang, Y., College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450002, China; Han, L., College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450002, China; Xia, L., College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450002, China; Yuan, Y., College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450002, China; Hu, H., College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450002, China, Key Laboratory for Animal-derived Food Safety of Henan Province, Zhengzhou, 450002, China","Porcine deltacoronavirus (PDCoV) is an emerging swine enteric coronavirus that causes diarrhea in piglets. However, the biological characteristics of PDCoV are unclear. In this study, the hemagglutination (HA) abilities of two PDCoV strains (CH-01 and HNZK-04) were investigated. Our results showed that PDCoV has the ability to agglutinate rabbit erythrocytes after virion pretreatment with trypsin or neuraminidase. Additionally, the HA assay results showed a significant positive correlation with the infectious viral titer. Our results suggest that assessing the HA activity of PDCoV may be a useful diagnostic method for investigating and surveilling PDCoV infections. © 2020 The Korean Society of Veterinary Science.",Hemagglutination; Neuraminidase; Porcine deltacoronavirus; Trypsin,,"Niederwerder, M.C., Hesse, R.A., Swine enteric coronavirus disease: a review of 4 years with porcine epidemic diarrhoea virus and porcine deltacoronavirus in the United States and Canada (2018) Transbound Emerg Dis, 65, pp. 660-675; Hu, H., Jung, K., Vlasova, A.N., Chepngeno, J., Lu, Z., Wang, Q., Saif, L.J., Isolation and characterization of porcine deltacoronavirus from pigs with diarrhea in the United States (2015) J Clin Microbiol, 53, pp. 1537-1548; Zhang, J., Porcine deltacoronavirus: Overview of infection dynamics, diagnostic methods, prevalence and genetic evolution (2016) Virus Res, 226, pp. 71-84; Mai, K., Feng, J., Chen, G., Li, D., Zhou, L., Bai, Y., Wu, Q., Ma, J., The detection and phylogenetic analysis of porcine deltacoronavirus from Guangdong Province in Southern China (2018) Transbound Emerg Dis, 65, pp. 166-173; Ryu, W.S., Diagnosis and methods (2017) Molecular Virology of Human Pathogenic Viruses, pp. 47-62. , Ryu WS (ed.), Academic Press, Boston; Park, J.E., Cruz, D.J., Shin, H.J., Trypsin-induced hemagglutination activity of porcine epidemic diarrhea virus (2010) Arch Virol, 155, pp. 595-599; Krempl, C., Schultze, B., Herrler, G., Analysis of cellular receptors for human coronavirus OC43 (1995) Adv Exp Med Biol, 380, pp. 371-374; Brian, D.A., Hogue, B.G., Kienzle, T.E., The coronavirus hemagglutinin esterase glycoprotein (1995) The Coronaviridae, pp. 165-179. , Siddell SG (ed.), Springer US, Boston; Krempl, C., Ballesteros, M.L., Enjuanes, L., Herrler, G., Isolation of hemagglutination-defective mutants for the analysis of the sialic acid binding activity of transmissible gastroenteritis virus (1998) Adv Exp Med Biol, 440, pp. 563-568; Li, W., van Kuppeveld, F.J., He, Q., Rottier, P.J., Bosch, B.J., Cellular entry of the porcine epidemic diarrhea virus (2016) Virus Res, 226, pp. 117-127; Mahmood, M.S., Siddique, M., Hussain, I., Khan, A., Mansoor, M.K., Tripsin-induced hemagglutination assay for the detection of infection bronchitis virus (2004) Pak Vet J, 24, pp. 662-668; Lin, C.M., Gao, X., Oka, T., Vlasova, A.N., Esseili, M.A., Wang, Q., Saif, L.J., Antigenic relationships among porcine epidemic diarrhea virus and transmissible gastroenteritis virus strains (2015) J Virol, 89, pp. 3332-3342; Schultze, B., Enjuanes, L., Herrler, G., Analysis of the sialic acid-binding activity of the transmissible gastroenteritis virus (1995) Adv Exp Med Biol, 380, pp. 367-370","Hu, H.; Henan Agricultural University, 63# Nongye Road, China; email: huhui2001@163.com",,Korean Society of Veterinary Science,1229845X,,,31940691,English,J. Vet. Sci.,Article,Final,Open Access,Scopus,2-s2.0-85077940988,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Yasri S., Wiwanitkit V.",56022182600;55628572491;,"Exported Wuhan novel coronavirus infection: An expected rate with reference to main destination of Chinese tourist, Thailand",2020,International Journal of Preventive Medicine,11,1,,,,,,10.4103/ijpvm.IJPVM_39_20,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082559124&doi=10.4103%2fijpvm.IJPVM_39_20&partnerID=40&md5=74e2a0286c728933ef2f3c4557e700c8,"KMT Primary Care Center, Bangkok, Thailand; Department of Community Medicine, Dr. DY Patil University, Pune, Maharashtra, India; Department of Tropical Medicine, Hainan Medical University, Haikou, China","Yasri, S., KMT Primary Care Center, Bangkok, Thailand; Wiwanitkit, V., Department of Community Medicine, Dr. DY Patil University, Pune, Maharashtra, India, Department of Tropical Medicine, Hainan Medical University, Haikou, China",[No abstract available],,,"Hsia, W., Emerging new coronavirus infection in Wuhan, China: Situation in early 2020 (2020) Case Study Case Rep, 10, pp. 8-9; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, , https://doi.org/10.1016/S0140'6736(20)30183'5, Epub ahead of print; Yasri, S., Wiwanitkit, V., Editorial: Wuhan coronavirus outbreak and imported case (2019) Adv Trop Med Pub Health Int, 9, pp. 1-2","Yasri, S.; KMT Primary Care CenterThailand; email: sorayasri@outlook.co.th",,Wolters Kluwer Medknow Publications,20087802,,,,English,Int. J. Prev. Med.,Letter,Final,,Scopus,2-s2.0-85082559124,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Kim C.-J.,57216083685;,New year and coronavirus,2020,Journal of Exercise Rehabilitation,16,1,41,,,,,10.12965/JER.2040082.041,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082557312&doi=10.12965%2fJER.2040082.041&partnerID=40&md5=4677ceadb21f527f1223684906587364,"Korean Society of Exercise Rehabilitation, Department of Physiology, College of Medicine Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, South Korea","Kim, C.-J., Korean Society of Exercise Rehabilitation, Department of Physiology, College of Medicine Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, South Korea",[No abstract available],,,,"Kim, C.-J.; Korean Society of Exercise Rehabilitation, Department of Physiology, College of Medicine Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, South Korea; email: changju@khu.ac.kr",,Korean Society of Exercise Rehabilitation,2288176X,,,,English,J. Exerc. Rehabil.,Editorial,Final,Open Access,Scopus,2-s2.0-85082557312,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Sriwijitalai W., Wiwanitkit V.",57190746000;55628572491;,Positive screening for Wuhan novel coronavirus infection at international airport: What's the final diagnosis for positive cases,2020,International Journal of Preventive Medicine,11,1,,,,,,10.4103/ijpvm.IJPVM_42_20,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082556962&doi=10.4103%2fijpvm.IJPVM_42_20&partnerID=40&md5=ab88df2d379b1d99cb73aa3ab8a1cc63,"RVT Medical Center, Bangkok, Thailand; Department of Tropical Medicine, Hainan Medical University, Haikou, China; Department of Community Medicine, Dr DY Patil University, Pune, Maharashtra, India","Sriwijitalai, W., RVT Medical Center, Bangkok, Thailand; Wiwanitkit, V., Department of Tropical Medicine, Hainan Medical University, Haikou, China, Department of Community Medicine, Dr DY Patil University, Pune, Maharashtra, India",[No abstract available],,,"Hsia, W., Emerging new coronavirus infection in Wuhan, China: Situation in early 2020 (2020) Case Study Case Rep, 10, pp. 8-9; Yasri, S., Wiwanitkit, V., Editorial: Wuhan coronavirus outbreak and imported case (2019) Adv Trop Med Pub Health Int, 9, pp. 1-2","Sriwijitalai, W.; RVT Medical CenterThailand; email: wonsriwi@gmail.com",,Wolters Kluwer Medknow Publications,20087802,,,,English,Int. J. Prev. Med.,Letter,Final,,Scopus,2-s2.0-85082556962,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Sookaromdee P., Wiwanitkit V.",57189377276;55628572491;,Imported Wuhan coronavirus infection: Is there any correlation with number of immigrants from endemic area and period after the first outbreak?,2020,International Journal of Preventive Medicine,11,1,,,,,,10.4103/ijpvm.IJPVM_41_20,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082555781&doi=10.4103%2fijpvm.IJPVM_41_20&partnerID=40&md5=d3f57515b070276990e23c2225f675c3,"TWS Medical Center, Bangkok, Thailand; Department of Community Medicine, Dr DY Patil University, Pune, Maharashtra, India; Department of Tropical Medicine, Hainan Medical University, China; Chulalongkorn University, Bangkok, Thailand","Sookaromdee, P., TWS Medical Center, Bangkok, Thailand; Wiwanitkit, V., Department of Community Medicine, Dr DY Patil University, Pune, Maharashtra, India, Department of Tropical Medicine, Hainan Medical University, China, Chulalongkorn University, Bangkok, Thailand",[No abstract available],,,"Hsia, W., Emerging new coronavirus infection in Wuhan, China: Situation in early 2020 (2020) Case Study Case Rep, 10, pp. 8-9; Yasri, S., Wiwanitkit, V., Editorial: Wuhan coronavirus outbreak and imported case (2019) Adv Trop Med Pub Health Int, 9, pp. 1-2","Wiwanitkit, V.; Department of Community Medicine, Dr DY Patil UniversityIndia; email: wviroj@yahoo.com",,Wolters Kluwer Medknow Publications,20087802,,,,English,Int. J. Prev. Med.,Letter,Final,Open Access,Scopus,2-s2.0-85082555781,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhao S., Cao P., Chong M.K.C., Gao D., Lou Y., Ran J., Wang K., Wang W., Yang L., He D., Wang M.H.",57194229769;57215190886;57206206657;38861547100;16417276600;57201898116;55712743100;57204925889;57105980700;7403045834;55596673500;,"The time-varying serial interval of the coronavirus disease (COVID-19) and its gender-specific difference: A data-driven analysis using public surveillance data in Hong Kong and Shenzhen, China from January 10 to February 15, 2020",2020,Infection Control and Hospital Epidemiology,,,,,,,,10.1017/ice.2020.64,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082529868&doi=10.1017%2fice.2020.64&partnerID=40&md5=79b45ea7b0d53c057dc4e6ce91b36d3b,"JC School of Public Health and Primary Care, Chinese University of Hong Kong, Hong Kong, Hong Kong; Shenzhen Research Institute, Chinese University of Hong Kong, Shenzhen, China; Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China; Department of Mathematics, Shanghai Normal University, Shanghai, China; Department of Applied Mathematics, Hong Kong Polytechnic University, Hong Kong, Hong Kong; School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, Hong Kong; Department of Medical Engineering and Technology, Xinjiang Medical University, Urumqi, 830011, China; School of Mathematics and Statistics, Huaiyin Normal University, Huaian, China; School of Nursing, Hong Kong Polytechnic University, Hong Kong, Hong Kong","Zhao, S., JC School of Public Health and Primary Care, Chinese University of Hong Kong, Hong Kong, Hong Kong, Shenzhen Research Institute, Chinese University of Hong Kong, Shenzhen, China; Cao, P., Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China; Chong, M.K.C., JC School of Public Health and Primary Care, Chinese University of Hong Kong, Hong Kong, Hong Kong, Shenzhen Research Institute, Chinese University of Hong Kong, Shenzhen, China; Gao, D., Department of Mathematics, Shanghai Normal University, Shanghai, China; Lou, Y., Department of Applied Mathematics, Hong Kong Polytechnic University, Hong Kong, Hong Kong; Ran, J., School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, Hong Kong; Wang, K., Department of Medical Engineering and Technology, Xinjiang Medical University, Urumqi, 830011, China; Wang, W., School of Mathematics and Statistics, Huaiyin Normal University, Huaian, China; Yang, L., School of Nursing, Hong Kong Polytechnic University, Hong Kong, Hong Kong; He, D., Department of Applied Mathematics, Hong Kong Polytechnic University, Hong Kong, Hong Kong; Wang, M.H., JC School of Public Health and Primary Care, Chinese University of Hong Kong, Hong Kong, Hong Kong, Shenzhen Research Institute, Chinese University of Hong Kong, Shenzhen, China",[No abstract available],coronavirus disease 2019; gender; mitigation; serial interval; statistical analysis,,"Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Ren, R., Wong, J.Y., Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia (2020) New England Journal of Medicine; Wu, J.T., Leung, K., Leung, G.M., Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan China: A modelling study (2020) The Lancet; Pem, F., The Interval between Successive Cases of an Infectious Disease (2003) American Journal of Epidemiology, 158 (11), pp. 1039-1047; The Collection of Press Releases by the Centre for Health Protection (CHP) of Hong Kong, , https://www.chp.gov.hk/en/media/116/index.html; The Collection of Outbreak Situation Reports of COVID-19 in Shenzhen, Shenzhen Municiple Health Commission, , http://wjw.sz.gov.cn/yqxx; Zhao, S., Gao, D., Zhuang, Z., Chong, M., Cai, Y., Ran, J., Cao, P., Wang, W., Estimating the serial interval of the novel coronavirus disease (COVID-19): A statistical analysis using the public data in Hong Kong from January 16 to February 15, 2020 (2020) MedRxiv, 2020. , 2002. 2021.20026559; Nishiura, H., Linton, N.M., Akhmetzhanov, A.R., Serial interval of novel coronavirus (2019-nCoV) infections (2020) MedRxiv, 2020. , 2002. 2003. 20019497; Novel Coronavirus Pneumonia Emergency Response Epidemiology Team The Epidemiological Characteristics of An Outbreak of 2019 Novel Coronavirus Diseases (COVID-19) in China, 41 (2), pp. 145-151","Zhao, S.; JC School of Public Health and Primary Care, Chinese University of Hong KongHong Kong; email: zhaoshi.cmsa@gmail.com",,Cambridge University Press,0899823X,,ICEPE,32146921,English,Infect. Control Hosp. Epidemiol.,Letter,Article in Press,Open Access,Scopus,2-s2.0-85082529868,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Arden M.A., Chilcot J.",7003677812;24280993000;,Health psychology and the coronavirus (COVID-19) global pandemic: A call for research,2020,British Journal of Health Psychology,,,,,,,,10.1111/bjhp.12414,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082529848&doi=10.1111%2fbjhp.12414&partnerID=40&md5=035e0eb5a7c5dcc2e4dfe69c70b9a840,"Centre for Behavioural Science and Applied Psychology, Sheffield Hallam University, United Kingdom; Institute of Psychiatry, Psychology and Neuroscience, King's College London, United Kingdom","Arden, M.A., Centre for Behavioural Science and Applied Psychology, Sheffield Hallam University, United Kingdom; Chilcot, J., Institute of Psychiatry, Psychology and Neuroscience, King's College London, United Kingdom",[No abstract available],,,"Bish, A., Michie, S., Demographic and attitudinal determinants of protective behaviours during a pandemic: A review (2010) British Journal of Health Psychology, 15, pp. 797-824. , https://doi.org/10.1348/135910710X485826; Brooks, S.K., Dunn, R., Amlôt, R., Rubin, G.J., Greenberg, N., A systematic, thematic review of social and occupational factors associated with psychological outcomes in healthcare employees during an infectious disease outbreak (2018) Journal of Occupational and Environmental Medicine, 60, pp. 248-257. , https://doi.org/10.1097/JOM.0000000000001235; Brooks, S.K., Webster, R.K., Smith, L.E., Woodland, L., Wessely, S., Greenberg, N., Rubin, G.J., The psychological impact of quarantine and how to reduce it: Rapid review of the evidence (2020) The Lancet, 395, pp. 912-920. , https://doi.org/10.1016/S0140-6736(20)30460-8; Lunn, P., Belton, C., Lavin, C., McGowan, F., Timmons, S., Robertson, D., (2020) Using behavioural science to help fight the coronavirus (No. WP656), , https://www.esri.ie/pubs/WP656.pdf, Economic and Social Research Institute (ESRI), Retrieved from; Michie, S., Van Stralen, M.M., West, R., The behaviour change wheel: A new method for characterising and designing behaviour change interventions (2011) Implementation Science, 6 (1), p. 42. , https://doi.org/10.1186/1748-5908-6-42; Taha, S., Matheson, K., Cronin, T., Anisman, H., Intolerance of uncertainty, appraisals, coping, and anxiety: The case of the 2009 H 1 N 1 pandemic (2014) British Journal of Health Psychology, 19, pp. 592-605. , https://doi.org/10.1111/bjhp.12058",,,John Wiley and Sons Ltd.,1359107X,,BJHPF,,English,Br. J. Health Psychol.,Editorial,Article in Press,,Scopus,2-s2.0-85082529848,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "McDermott M.M., Newman A.B.",7402677688;56962723400;,Preserving Clinical Trial Integrity during the Coronavirus Pandemic,2020,JAMA - Journal of the American Medical Association,,,4689,,,,,10.1001/jama.2020.4689,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082528685&doi=10.1001%2fjama.2020.4689&partnerID=40&md5=31e467e57194c624a38032bb5b3107f5,"Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States; JAMA; Department of Epidemiology, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, United States","McDermott, M.M., Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States, JAMA; Newman, A.B., Department of Epidemiology, University of Pittsburgh, Graduate School of Public Health, Pittsburgh, PA, United States",[No abstract available],,,"Trends, Charts, and Maps, , http://clinicaltrials.gov/ct2/resources/trends, ClinicalTrials.gov. Accessed March 16, 2020; Pahor, M., Guralnik, J.M., Ambrosius, W.T., Effect of structured physical activity on prevention of major mobility disability in older adults: The LIFE study randomized clinical trial (2014) JAMA, 311 (23), pp. 2387-2396. , http://jamanetwork.com/article.aspx?doi=10.1001/jama.2014.5616, LIFE Study Investigators; (2020) FDA Guidance on Conduct of Clinical Trials of Medical Products during COVID-19 Pandemic: Guidance for Industry, Investigators, and Institutional Review Boards. US Food and Drug Administration, , http://www.fda.gov/regulatory-information/search-fda-guidance-documents/fda-guidance-conduct-clinical-trials-medical-products-during-covid-19-pandemic, Published March. Accessed March 18, 2020","Mcdermott, M.M.; Department of Medicine, Feinberg School of Medicine, Northwestern UniversityUnited States; email: mdm608@northwestern.edu",,American Medical Association,987484,,JAMAA,32211830,English,JAMA,Note,Article in Press,Open Access,Scopus,2-s2.0-85082528685,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Hurt B., Kligerman S., Hsiao A.",56880214600;33167627100;57207967879;,Deep Learning Localization of Pneumonia: 2019 Coronavirus (COVID-19) Outbreak,2020,Journal of Thoracic Imaging,,,,,,,,10.1097/RTI.0000000000000512,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082523248&doi=10.1097%2fRTI.0000000000000512&partnerID=40&md5=341285904e15dd3d6eb5eaad568beadb,"Department of Radiology, University of California San Diego, San Diego, CA, United States","Hurt, B., Department of Radiology, University of California San Diego, San Diego, CA, United States; Kligerman, S., Department of Radiology, University of California San Diego, San Diego, CA, United States; Hsiao, A., Department of Radiology, University of California San Diego, San Diego, CA, United States",[No abstract available],Artificial intelligence; Coronavirus; COVID-19; Deep learning; Outbreak; Pneumonia; Radiographs; Thoracic imaging,,"Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study (2020) Lancet (London, England), 6736, pp. 1-7; (2019) Disease Burden of Influenza, , www.cdc.gov/flu/about/burden/index.html, Accessed February 18, 2020; Hurt, B., Kligerman, S., Yen, A., Augmenting interpretation of chest radiographs with deep learning probability maps (2020) J Thorac Imaging; Holshue, M.L., DeBolt, C., Lindquist, S., First case of 2019 novel coronavirus in the United States (2020) N Engl J Med, 382, pp. 929-936; Song, F., Shi, N., Shan, F., Emerging 2019 novel coronavirus (2019-nCoV) pneumonia (2020) Radiology, p. 200274; Ng, M.-Y., Lee, E.Y., Yang, J., Imaging profile of the COVID-19 infection: Radiologic findings and literature review (2020) Radiol Cardiothorac Imaging, 2, p. e200034; Kong, W., Agarwal, P.P., Chest imaging appearance of COVID-19 infection (2020) Radiol Cardiothorac Imaging, 2, p. e200028; Zech, J.R., Badgeley, M.A., Liu, M., Variable generalization performance of a deep learning model to detect pneumonia in chest radiographs: A cross-sectional study (2018) PLoS Med, 15, pp. 1-17","Hurt, B.9500 Gilman Drive #0888, United States; email: brhurt@ucsd.edu",,Lippincott Williams and Wilkins,8835993,,JTIME,32205822,English,J. Thorac. Imaging,Article,Article in Press,,Scopus,2-s2.0-85082523248,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Jørstad Ø.K., Moe M.C., Eriksen K., Petrovski G., Bragadóttir R.",56529517700;7003319266;57194280841;16507366300;6602549940;,"Coronavirus disease 2019 (COVID-19) outbreak at the Department of Ophthalmology, Oslo University Hospital, Norway",2020,Acta Ophthalmologica,,,,,,,,10.1111/aos.14426,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082512133&doi=10.1111%2faos.14426&partnerID=40&md5=a7acc000d19e6ad7a4813ecb2218e76f,"Department of Ophthalmology, Oslo University Hospital, Oslo, Norway; Institute of clinical medicine, Faculty of medicine, University of Oslo, Oslo, Norway","Jørstad, Ø.K., Department of Ophthalmology, Oslo University Hospital, Oslo, Norway, Institute of clinical medicine, Faculty of medicine, University of Oslo, Oslo, Norway; Moe, M.C., Department of Ophthalmology, Oslo University Hospital, Oslo, Norway, Institute of clinical medicine, Faculty of medicine, University of Oslo, Oslo, Norway; Eriksen, K., Department of Ophthalmology, Oslo University Hospital, Oslo, Norway; Petrovski, G., Department of Ophthalmology, Oslo University Hospital, Oslo, Norway, Institute of clinical medicine, Faculty of medicine, University of Oslo, Oslo, Norway; Bragadóttir, R., Department of Ophthalmology, Oslo University Hospital, Oslo, Norway, Institute of clinical medicine, Faculty of medicine, University of Oslo, Oslo, Norway",[No abstract available],,,"(2020), https://www.fhi.no/nyheter/2020/rad-til-reisende-i-nye-omrader-med-lokal-smittespredning-av-covid-19/, (accessed March 8, 2020); (2020), https://www.who.int/dg/speeches/detail/who-director-general-s-remarks-at-the-media-briefing-on-2019-ncov-on-11-february-2020, (accessed March 8, 2020); (2020), https://www.who.int/news-room/articles-detail/key-considerations-for-repatriation-and-quarantine-of-travellers-in-relation-to-the-outbreak-of-novel-coronavirus-2019-ncov/, (accessed March 9, 2020); Wu, Z., McGoogan, J.M., Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China (2020) JAMA, , https://doi.org/10.1001/jama.2020.2648","Jørstad, Ø.K.; Department of Ophthalmology, Oslo University HospitalNorway; email: OEYJOE@ous-hf.no",,Blackwell Publishing Ltd,1755375X,,,,English,Acta Ophthalmol.,Letter,Article in Press,Open Access,Scopus,2-s2.0-85082512133,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wang Y., Di Y., Ye J., Wei W.",57216043301;57216037727;7403237692;57216038482;,Study on the public psychological states and its related factors during the outbreak of coronavirus disease 2019 (COVID-19) in some regions of China,2020,"Psychology, Health and Medicine",,,,,,,,10.1080/13548506.2020.1746817,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082509591&doi=10.1080%2f13548506.2020.1746817&partnerID=40&md5=cf6c88c26c3d8cbed0f8f29b15ba6b5d,"Department of Ophthalmology, Xuanwu Hospital, Capital Medical University, Beijing, China; Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China; Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology& Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China","Wang, Y., Department of Ophthalmology, Xuanwu Hospital, Capital Medical University, Beijing, China; Di, Y., Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China; Ye, J., Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China; Wei, W., Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology& Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China","Background: As COVID-19 occurs suddenly and is highly contagious, this will inevitably cause people anxiety, depression, etc. The study on the public psychological states and its related factors during the COVID-19 outbreak is of practical significance. Methods: 600 valid questionnaires were received. The Self-Rating Anxiety Scale (SAS) and the Self-Rating Depression Scale (SDS) were used. Results: Females’ anxiety risk was 3.01 times compared to males (95% CI 1.39–6.52). Compared with people below 40 years old, the anxiety risk of people above 40 years old was 0.40 times (95% CI 0.16–0.99). SDS results indicated that the difference between education level and occupation was statistically significant (p = 0.024, 0.005). Compared to people with a master’s degree or above, those with a bachelor’s degree group had a depression risk of 0.39 times (95% CI 0.17–0.87). Compared with professionals, industrial service workers and other staff had a depression risk of 0.31 times (95% CI 0.15–0.65) and 0.38 times (95% CI 0.15–0.93). Conclusions: 600 questionnaire participants were psychologically stable. Non-anxiety and non-depression rates were 93.67% and 82.83%, respectively. There were anxiety in 6.33% and depression in 17.17%. Therefore, we should pay attention to the psychological states of the public. © 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group.",anxiety; COVID-19; depression; public psychological states; related factors,,"Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Zhang, L., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study[J] (2020) The Lancet, 395 (10223), pp. 507-513. , https://doi.org/10.1016/S0140-6736(20)30211-7; Craske, M.G., Stein, M.B., Anxiety (2016) Lancet, 388 (10063), pp. 3048-3059. , https://doi.org/10.1016/S0140-6736(16)30381-6, December, 17, Epub 2016 Jun 24; Drury, J., Carter, H., Cocking, C., Ntontis, E., Tekin Guven, S., Amlôt, R., (2019) Facilitating collective psychosocial resilience in the public in emergencies: Twelve recommendations based on the social identity approach, , https://doi.org/10.3389/fpubh.2019.00141, Front. Public Health, 2019; 6(7), 141; Guan, W.-J., Zheng-yi, N., Yu, H., Clinical characteristics of 2019 novel coronavirus infection in China (2020) medRxiv, , https://doi.org/10.1101/2020.02.06.20020974, W. Liang, C. Ou, J. He, L. Liu, H. Shan, C. Lei, D.S.C. Hui, B. Du, L. Li, G. Zeng, K.-Y. Yuen, R. Chen, C. Tang, T. Wang, P. Chen, J. Xiang, S. Li,.. N. Zhong; Hong, X., Currier, G.W., Zhao, X., Jiang, Y., Zhou, W., Wei, J., Posttraumatic stress disorder in convalescent severe acute respiratory syndrome patients: A 4-year follow-up study[J] (2009) General Hospital Psychiatry, 31 (6), pp. 546-554. , https://doi.org/10.1016/j.genhosppsych.2009.06.008, Nov-December, Epub 2009 Aug 27; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Cao, B., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) The Lancet, 395 (10223), pp. 497-506. , https://doi.org/10.1016/S0140-6736(20)30183-5, January, 24, Epub ahead of print; Emerging understandings of 2019-nCoV (2020) Lancet, 395 (10221), p. 311. , https://doi.org/10.1016/S0140-6736(20)30186-0; Lee, S.M., Kang, W.S., Cho, A.R., Kim, T., Park, J.K., Psychological impact of the 2015 MERS outbreak on hospital workers and quarantined hemodialysis patients[J] (2018) Comprehensive Psychiatry, (87), pp. 123-127. , https://doi.org/10.1016/j.comppsych.2018.10.003, November; Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia[J/OL] (2020) The New England Journal of Medicine, , https://www.nejm.org/DOI/10.1056/NEJMoa2001316, 382(13), 1199–1207, [published online ahead of print January 29, 2020], Wang X., Zhou L., Tong Y., Ren R., Leung K. S. M., Lau E. H. Y., Wong J. Y., Xing X., Xiang N., Wu Y., Li C., Chen Q., Li D., Liu T., Zhao J., Li M., Tu W., Chen C.,.. Feng Z; Lu, R., Zhao, X., Li, J., Niu, P., Yang, B., Wu, H., Wang, W., Tan, W., Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding (2020) The Lancet, 395 (10224), pp. 565-574. , https://doi.org/10.1016/S0140-6736(20)30251-8; 〔2020〕No.103. [EB/OL]. (2020-02-05) [2020-02-06, , http://www.gov.cn/zhengce/zhengceku/2020-02/05/content_5474791.htm; http://www.gov.cn/zhengce/zhengceku/2020-01/27/content_5472433.htm, National Health Commission of the People’s Republic of China. Notification of guidelines for emergency; Ren, L.-L., Wang, Y.-M., Wu, Z.-Q., Xiang, Z.-C., Guo, L., Xu, T., Jiang, Y.-Z., Wang, J.-W., Identification of a novel coronavirus causing severe pneumonia in human: A descriptive study (2020) Chinese Medical Journal, , https://doi.org/10.1097/CM9.0000000000000722, February, 11, Epub ahead of print; Samakouri, M., Bouhos, G., Kadoglou, M., Giantzelidou, A., Tsolaki, K., Livaditis, M., Standardization of the Greek version of Zung’s Self-rating Anxiety Scale(SAS).[J] (2012) Psychiatriki, 23 (3), pp. 212-220. , Jul-September; Shang, L.L., Huang, Y.Q., Liu, Z.R., A cross-sectional survey of disability attributed to mental disorders and service use in China (2017) Chinese Medical Journal, 130 (12), pp. 1441-1445. , https://doi.org/10.4103/0366-6999.207462, June, 20, Chen H. G; Yang, L., Zhao, Y., Wang, Y., Liu, L., Zhang, X., Li, B., Cui, R., The effects of psychological stress on depression (2015) Current Neuropharmacology, 13 (4), pp. 494-504. , https://doi.org/10.2174/1570159x1304150831150507; Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., song, J., Zhao, X., Tan, W., A novel coronavirus from patients with pneumonia in China, 2019[J/OL] (2020) The New England Journal of Medicine, 382 (8), pp. 727-733. , https://www.nejm.org/DOI/full/10.1056/NEJMoa2001017, E1 [2020-1-24], [published online ahead of print January 24, 2020]; Zung, W.W.K., A Self-rating Depression Scale (1965) Archives of General Psychiatry, 12 (1), pp. 63-70. , https://doi.org/10.1001/archpsyc.1965.01720310065008; Zung, W.W.K., A rating instrument for anxiety disorders (1971) Psychosomatics, 12 (6), pp. 371-379. , https://doi.org/10.1016/S0033-3182(71)71479-0, Nov-December","Wei, W.; Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology&Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical UniversityChina; email: weiwenbintr@163.com",,Routledge,13548506,,PHMEF,,English,Psychol. Health Med.,Article,Article in Press,Open Access,Scopus,2-s2.0-85082509591,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Qu G., Li X., Hu L., Jiang G.",26641461100;57215096012;57216041079;57193618515;,An Imperative Need for Research on the Role of Environmental Factors in Transmission of Novel Coronavirus (COVID-19),2020,Environmental Science and Technology,,,,,,,,10.1021/acs.est.0c01102,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082508547&doi=10.1021%2facs.est.0c01102&partnerID=40&md5=23fa33adbdab310ed758b4525c7e4e78,"State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; Department of Civil and Environmental Engineering, Hong Kong Polytechnic University, Kowloon, Hung Hom, Hong Kong; Institute of Environment and Health, Hangzhou Institute for Advanced Study, UCAS, Hangzhou, 310000, China; Institute of Environment and Health, Jianghan University, Wuhan, 430056, China; University of Chinese Academy of Sciences, Beijing, 100049, China","Qu, G., State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China, Institute of Environment and Health, Hangzhou Institute for Advanced Study, UCAS, Hangzhou, 310000, China, Institute of Environment and Health, Jianghan University, Wuhan, 430056, China, University of Chinese Academy of Sciences, Beijing, 100049, China; Li, X., Department of Civil and Environmental Engineering, Hong Kong Polytechnic University, Kowloon, Hung Hom, Hong Kong; Hu, L., State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China, Institute of Environment and Health, Hangzhou Institute for Advanced Study, UCAS, Hangzhou, 310000, China, Institute of Environment and Health, Jianghan University, Wuhan, 430056, China, University of Chinese Academy of Sciences, Beijing, 100049, China; Jiang, G., State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China, Institute of Environment and Health, Hangzhou Institute for Advanced Study, UCAS, Hangzhou, 310000, China, Institute of Environment and Health, Jianghan University, Wuhan, 430056, China, University of Chinese Academy of Sciences, Beijing, 100049, China",[No abstract available],,,"Wang, C., Horby, P.W., Hayden, F.G., Gao, G.F., A novel coronavirus outbreak of global health concern (2020) Lancet, 395 (10223), pp. 470-473; Weber, D.J., Rutala, W.A., Fischer, W.A., Kanamori, H., Sickbert-Bennett, E.E., Emerging infectious diseases: Focus on infection control issues for novel coronaviruses (Severe Acute Respiratory Syndrome-CoV and Middle East Respiratory Syndrome-CoV), hemorrhagic fever viruses (Lassa and Ebola), and highly pathogenic avian influenza viruses, A(H5N1) and A(H7N9) (2016) Am. J. Infect. Control, 44 (5), pp. E91-E100; Casanova, L., Rutala, W.A., Weber, D.J., Sobsey, M.D., Survival of surrogate coronaviruses in water (2009) Water Res., 43 (7), pp. 1893-1898; Peiris, J.S., Chu, C.M., Cheng, V.C., Chan, K.S., Hung, I.F., Poon, L.L., Law, K.I., Group, H.U.S.S., Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: A prospective study (2003) Lancet, 361 (9371), pp. 1767-1772; Yu, I.T., Li, Y., Wong, T.W., Tam, W., Chan, A.T., Lee, J.H., Leung, D.Y., Ho, T., Evidence of airborne transmission of the severe acute respiratory syndrome virus (2004) N. Engl. J. Med., 350 (17), pp. 1731-1739","Jiang, G.; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of SciencesChina; email: gbjiang@rcees.ac.cn",,American Chemical Society,0013936X,,ESTHA,32202420,English,Environ. Sci. Technol.,Note,Article in Press,Open Access,Scopus,2-s2.0-85082508547,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Hao W., Li M., Huang X.",57204553702;57215964432;57215966850;,"First atypical case of 2019 novel coronavirus in Yan'an, China",2020,Clinical Microbiology and Infection,,,,,,,,10.1016/j.cmi.2020.02.011,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082500090&doi=10.1016%2fj.cmi.2020.02.011&partnerID=40&md5=9328a9cf5f623e18643909fbc29cf2a9,"Department of Respiratory Medicine, The Affiliated Hospital of Yan'an University, Yan'an, Shaanxi 716099, China; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi province 710061, China; Department of Radiology, The Affiliated Hospital of Yan'an University, Yan'an, Shaanxi 716099, China","Hao, W., Department of Respiratory Medicine, The Affiliated Hospital of Yan'an University, Yan'an, Shaanxi 716099, China, Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi province 710061, China; Li, M., Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi province 710061, China; Huang, X., Department of Radiology, The Affiliated Hospital of Yan'an University, Yan'an, Shaanxi 716099, China",[No abstract available],,,"Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet; Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med; Li, Q., Xuhua, G., Peng, W., Xiaoye, W., Lei, Z., Yeqing, T., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med","Hao, W.; Department of Respiratory Medicine, The Affiliated Hospital of Yan'an University, No. 43 North Street, Baota District, China; email: hwdokgood@hotmail.com",,Elsevier B.V.,1198743X,,CMINF,32087323,English,Clin. Microbiol. Infect.,Letter,Article in Press,Open Access,Scopus,2-s2.0-85082500090,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Brennan P.A., Oeppen R.S.",7402304465;6602198390;,Editorial: safe healthcare teams during the coronavirus outbreak,2020,British Journal of Oral and Maxillofacial Surgery,,,,,,,,10.1016/j.bjoms.2020.03.011,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082499599&doi=10.1016%2fj.bjoms.2020.03.011&partnerID=40&md5=7373f13d1772d754b0f44bc82822e71d,"Queen Alexandra Hospital, Portsmouth, PO6 3LY, United Kingdom; University Hospitals Southampton, Southampton, SO16 6YD, United Kingdom","Brennan, P.A., Queen Alexandra Hospital, Portsmouth, PO6 3LY, United Kingdom; Oeppen, R.S., University Hospitals Southampton, Southampton, SO16 6YD, United Kingdom",[No abstract available],,,"Tang, B., Bragazzi, N.L., Li, Q., An updated estimation of the risk of transmission of the novel coronavirus (2019-nCov) (2020) Infect Dis Model, 5, pp. 248-255; Wilder-Smith, A., Chiew, C.J., Lee, V.J., Can we contain the COVID-19 outbreak with the same measures as for SARS? (2020) Lancet Infect Dis, , S1473-3099(20)30129-8; https://www.bbc.co.uk/news/business-51737030, Coronavirus: can you stop people stockpiling. BBC News 9 March 2020. Available at: (accessed 10 March 2020); https://www.scmp.com/news/asia/australasia/article/3074070/coronavirus-tussle-over-toilet-paper-prompts-australia-police, Coronavirus: Tussle over toilet paper prompts Australia police to call for calm. Available at: (accessed 10 March 2020); Jiang, X., Deng, L., Zhu, Y., Psychological crisis intervention during the outbreak period of new coronavirus pneumonia from experience in Shanghai (2020) Psychiatry Res, 286; Ragau, S., Hitchcock, R., Craft, J., Using the HALT model in an exploratory quality improvement initiative to reduce medication errors (2018) Br J Nurs, 27, pp. 1330-1335; Davidson, M., Brennan, P.A., Leading article: What has an Airbus A380 Captain got to do with OMFS? Lessons from aviation to improve patient safety (2019) Br J Oral Maxillofac Surg, 57, pp. 407-411; Brennan, P.A., Holden, C., Shaw, G., Leading article: What can we do to improve individual and team situational awareness to benefit patient safety? (2020) Br J Oral Maxillofac Surg, , pii: S0266-4356(20)30034-6. [Epub ahead of print]; Oeppen, R.S., Brennan, P.A., Taggart, I., Human factors in medicine: the art of common sense at work (2019) Br J Hosp Med (Lond), 80, pp. 424-425; Parry, D.A., Oeppen, R.S., Amin, M.S., Sleep: its importance and the effects of deprivation on surgeons and other healthcare professionals (2018) Br J Oral Maxillofac Surg, 56, pp. 663-666; Parry, D., Oeppen, R.S., Gass, H., Impact of hydration and nutrition on personal performance in the clinical workplace (2017) Br J Oral Maxillofac Surg, 55, pp. 995-998; Vijendren, A., Yung, M., Sanchez, J., An exploratory investigation of personality types attracted to ENT (2016) J Laryngol Otol, 130, pp. 587-595; Petitta, L., Jiang, L., Burning out? Watch your own incivility and the emotions you spread (2019) Work, 64, pp. 671-683; Bajaj, A.K., Work/Life Balance: it Is Just Plain Hard (2018) Ann Plast Surg, 80, pp. S245-S246; https://www.gov.uk/government/publications/wuhan-novel-coronavirus-self-isolation-for-patients-undergoing-testing/advice-sheet-home-isolation","Brennan, P.A.; Queen Alexandra HospitalUnited Kingdom; email: Peter.brennan@porthosp.nhs.uk",,Churchill Livingstone,2664356,,BJOSE,,English,Br. J. Oral Maxillofac. Surg.,Editorial,Article in Press,,Scopus,2-s2.0-85082499599,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Hao W., Li M.",57204553702;57215964432;,Clinical features of atypical 2019 novel coronavirus pneumonia with an initially negative RT-PCR assay,2020,Journal of Infection,,,,,,,,10.1016/j.jinf.2020.02.008,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082496876&doi=10.1016%2fj.jinf.2020.02.008&partnerID=40&md5=349ae04ae2d37695f872a484855d4f60,"Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Yan'an University, Yan'an, Shaanxi 716099, China; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'anShaanxi Province 710061, China","Hao, W., Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Yan'an University, Yan'an, Shaanxi 716099, China, Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'anShaanxi Province 710061, China; Li, M., Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'anShaanxi Province 710061, China",[No abstract available],,,"Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., A novel coronavirus from patients with pneumonia in china, 2019 (2020) N Engl J Med; Kanne Jeffrey, P., Chest CT findings in 2019 novel coronavirus (2019-nCoV) infections from Wuhan, China: key points for the radiologist (2020) Radiology; Xie, X., Zhong, Z., Zhao, W., Zheng, C., Wang, F., Liu, J., Chest CT for typical 2019-nCoV pneumonia: relationship to negative RT-PCR testing (2020) Radiology","Hao, W.; Department of Respiratory Medicine, he Affiliated Hospital of Yan'an University, No. 43 North Street, Baota District, China; email: hwdokgood@hotmail.com",,W.B. Saunders Ltd,1634453,,JINFD,32092387,English,J. Infect.,Letter,Article in Press,Open Access,Scopus,2-s2.0-85082496876,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Su Y.-J., Lai Y.-C.",21733630200;57215968769;,Comparison of clinical characteristics of coronavirus disease (COVID-19) and severe acute respiratory syndrome (SARS) as experienced in Taiwan,2020,Travel Medicine and Infectious Disease,,,101625,,,,,10.1016/j.tmaid.2020.101625,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082495157&doi=10.1016%2fj.tmaid.2020.101625&partnerID=40&md5=33b20623c9a95f9cb574d283846bab9f,"Poison Centre, Emergency Department, Mackay Memorial Hospital, Taipei, Taiwan; Department of Medicine, Mackay Medical College, New Taipei City, Taiwan; Department of Anaesthesiology, Musoon Women's Clinic, Taipei, Taiwan","Su, Y.-J., Poison Centre, Emergency Department, Mackay Memorial Hospital, Taipei, Taiwan, Department of Medicine, Mackay Medical College, New Taipei City, Taiwan; Lai, Y.-C., Department of Anaesthesiology, Musoon Women's Clinic, Taipei, Taiwan",[No abstract available],Epidemiology; Laboratory characteristics; Mortality; SARS-CoV-2; Symptoms,,"WHO, Clinical management of severe acute respiratory infection when Novel coronavirus (nCoV) infection is suspected: interim guidance (2020), https://www.who.int/internalpublications-detail/clinical-management-of-severe-acute-respiratoryinfection-when-novel-coronavirus-(ncov)-infection-is-suspected, (accessed Jan 20, 2020); World Health Organization, Case definitions for surveillance of severe acute respiratory syndrome (SARS) http://www.who.int/csr/sars/casedefinition/en, Available at; Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Early transmission dynamics in wuhan, China, of novel coronavirus-infected pneumonia [published online ahead of print, 2020 jan 29] (2020) N Engl J Med; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China [published online ahead of print, 2020 Jan 24] (2020) Lancet, S0140–6736 (20), pp. 30183-30185; Wang, W., Tang, J., Wei, F., Updated understanding of the outbreak of 2019 novel coronavirus (2019-nCoV) in Wuhan, China [published online ahead of print, 2020 Jan 29] (2020) J Med Virol; Leung, G.M., Hedley, A.J., Ho, L.M., Chau, P., Wong, I.O.L., Thach, T.Q., The epidemiology of severe acute respiratory syndrome in the 2003 Hong Kong epidemic: an analysis of all 1755 patients (2004) Ann Intern Med, 141 (9), pp. 662-673","Su, Y.-J.No. 92, Sec 2, North Chung Shan Rd, Taiwan; email: yjsu.5885@mmh.org.tw",,Elsevier USA,14778939,,TMIDA,32184131,English,Travel Med. Infect. Dis.,Letter,Article in Press,Open Access,Scopus,2-s2.0-85082495157,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Hanscheid T., Valadas E., Grobusch M.P.",7004266513;6603593138;7004891682;,Coronavirus 2019-nCoV: Is the genie already out of the bottle?,2020,Travel Medicine and Infectious Disease,,,101577,,,,,10.1016/j.tmaid.2020.101577,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082488133&doi=10.1016%2fj.tmaid.2020.101577&partnerID=40&md5=015e67481792d3804cbbe508532aa070,"Instituto de Microbiologia, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal; Clínica Doenças Infecciosas e Parasitárias, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal; Center of Tropical Medicine and Travel Medicine, Department of Infectious Diseases, Division of Internal Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands","Hanscheid, T., Instituto de Microbiologia, Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal; Valadas, E., Clínica Doenças Infecciosas e Parasitárias, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal; Grobusch, M.P., Center of Tropical Medicine and Travel Medicine, Department of Infectious Diseases, Division of Internal Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands",[No abstract available],,,"WHO, Novel Coronavirus (2019-nCoV) situation reports https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports, (Accessed 3 February 2020); Baharoon, S., Memish, Z.A., MERS-CoV as an emerging respiratory illness: a review of prevention methods (2019) Trav Med Infect Dis, p. 101520; Totura, A.L., Bavari, S., Broad-spectrum coronavirus antiviral drug discovery (2019) Expert Opin Drug Discov, 14 (4), pp. 397-412. , Epub 2019 Mar 8; Zumla, A., Dar, O., Kock, R., Muturi, M., Ntoumi, F., Kaleebu, P., Eusebio, M., Petersen, E., Taking forward a 'One Health' approach for turning the tide against the Middle East respiratory syndrome coronavirus and other zoonotic pathogens with epidemic potential (2016) Int J Infect Dis, 47, pp. 5-9. , Epub 2016 Jun 15; OECD Data, Meat consumption https://data.oecd.org/agroutput/meat-consumption.htm, (Accessed 5 February 2020); D'Alessandro, S., Scaccabarozzi, D., Signorini, L., Perego, F., Ilboudo, D.P., Ferrante, P., The use of antimalarial drugs against viral infection (2020) Microorganisms, 8, p. 85; Callaway, E., Make Ebola a thing of the past': first vaccine against deadly virus approved (2019) Nature, 575 (7783), pp. 425-426; Rothe, C., Schunk, M., Sothmann, P., Bretzel, G., Froeschl, G., Wallrauch, C., Zimmer, T., Hoelscher, M., Transmission of 2019-nCoV infection from an asymptomatic contact in Germany (2020) N Engl J Med, , [Epub ahead of print]; Nishiura, H., Case fatality ratio of pandemic influenza (2010) Lancet Infect Dis, 10 (7), pp. 443-444; Chen, N., Zhou, M., Dong, X., Qu, Q., Gong, F., Han, Y., Qiu, Y., Zhang, L., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, , Published: January 30, 2020; Parpia, A.S., Ndeffo-Mbah, M.L., Wenzel, N.S., Galvani, A.P., Effects of response to 2014-2015 Ebola outbreak on deaths from malaria, HIV/AIDS, and tuberculosis, west africa (2016) Emerg Infect Dis, 22 (3), pp. 433-441","Hanscheid, T.; Instituto de Microbiologia, Faculdade de Medicina, Universidade de Lisboa, Avendia Prof. Egas Moniz, Portugal; email: t.hanscheid@medicina.ulisboa.pt",,Elsevier USA,14778939,,TMIDA,32044388,English,Travel Med. Infect. Dis.,Letter,Article in Press,Open Access,Scopus,2-s2.0-85082488133,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wen F., Yu H., Guo J., Li Y., Luo K., Huang S.",57206272701;57215966071;56431576300;57215970906;57215971951;57196220476;,Identification of the hyper-variable genomic hotspot for the novel coronavirus SARS-CoV-2,2020,Journal of Infection,,,,,,,,10.1016/j.jinf.2020.02.027,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082472174&doi=10.1016%2fj.jinf.2020.02.027&partnerID=40&md5=f4adc262c20871063106b546a54bbc03,"College of Life Science and Engineering, Foshan University, Foshan, Guangdong 528231, China; Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, 200241, China; College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi 330045, China; College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong 510642, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009, China","Wen, F., College of Life Science and Engineering, Foshan University, Foshan, Guangdong 528231, China; Yu, H., Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, 200241, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, 225009, China; Guo, J., College of Life Science and Engineering, Foshan University, Foshan, Guangdong 528231, China; Li, Y., College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, Jiangxi 330045, China; Luo, K., College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong 510642, China; Huang, S., College of Life Science and Engineering, Foshan University, Foshan, Guangdong 528231, China",[No abstract available],,,"Zhang, J., Ma, K., Li, H., Liao, M., Qi, W., The continuous evolution and dissemination of 2019 novel human coronavirus (2020) J. Infect.; Wu, A., Peng, Y., Huang, B., Ding, X., Wang, X., Niu, P., Genome composition and divergence of the novel coronavirus (2019-nCoV) originating in China (2020) Cell Host Microbe; Wu, F., Zhao, S., Yu, B., Chen, Y.M., Wang, W., Song, Z.G., A new coronavirus associated with human respiratory disease in china (2020) Nature; Zhou, P., Yang, X.L., Wang, X.G., Hu, B., Zhang, L., Zhang, W., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature; Shu, Y., McCauley, J., GISAID: global initiative on sharing all influenza data - from vision to reality (2017) Euro. Surveill., 22 (13); Marra, M.A., The genome sequence of the SARS-associated coronavirus (2003) Science, 300 (5624), pp. 1399-1404; Jones, D.T., Taylor, W.R., Thornton, J.M., The rapid generation of mutation data matrices from protein sequences (1992) Comput. Appl. Biosci., 8 (3), pp. 275-282; Ceraolo, C., Giorgi, F.M., Genomic variance of the 2019-nCoV coronavirus (2020) J. Med. Virol.; Wong, S.K., Li, W., Moore, M.J., Choe, H., Farzan, M., A 193-amino acid fragment of the SARS coronavirus S protein efficiently binds angiotensin-converting enzyme 2 (2004) J Biol Chem, 279 (5), pp. 3197-3201; Lokugamage, K.G., Narayanan, K., Huang, C., Makino, S., Severe acute respiratory syndrome coronavirus protein nsp1 is a novel eukaryotic translation inhibitor that represses multiple steps of translation initiation (2012) J. Virol., 86 (24), pp. 13598-13608","Wen, F.; College of Life Science and Engineering, Foshan UniversityChina; email: wenfengjlu@163.com",,W.B. Saunders Ltd,1634453,,JINFD,32145215,English,J. Infect.,Letter,Article in Press,Open Access,Scopus,2-s2.0-85082472174,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Lippi G., Henry B.M.",57205413642;56689347500;,Active smoking is not associated with severity of coronavirus disease 2019 (COVID-19),2020,European Journal of Internal Medicine,,,,,,,,10.1016/j.ejim.2020.03.014,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082469236&doi=10.1016%2fj.ejim.2020.03.014&partnerID=40&md5=d84a259b382aa70b3a8ad6332da69465,"Section of Clinical Biochemistry, Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy; Cardiac Intensive Care Unit The Heart Institute Cincinnati Children's Hospital Medical Center, Ohio, United States","Lippi, G., Section of Clinical Biochemistry, Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy; Henry, B.M., Cardiac Intensive Care Unit The Heart Institute Cincinnati Children's Hospital Medical Center, Ohio, United States",[No abstract available],Cigarette; Coronavirus; COVID-19; Smoking,,"Mattiuzzi, C., Lippi, G., Which lessons shall we learn from the 2019 novel coronavirus outbreak? (2020) Ann Transl Med, 8, p. 48; The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) — China (2020) 2020. China CDC Wkly, 2, pp. 113-122; Parascandola, M., Xiao, L., Tobacco and the lung cancer epidemic in China (2019) Transl Lung Cancer Res, 8, pp. S21-S30; Wan, Y., Shang, J., Graham, R., Baric, R.S., Li, F., Receptor recognition by novel coronavirus from wuhan: an analysis based on decade-long structural studies of sars (2020) J Virol, , pii: JVI.00127-20[Epub ahead of print]; Oakes, J.M., Fuchs, R.M., Gardner, J.D., Lazartigues, E., Yue, X., Nicotine and the renin-angiotensin system (2018) Am J Physiol Regul Integr Comp Physiol, 315 (5), pp. R895-R906; Guan, W.J., Ni, Z.Y., Hu, Y., Liang, W.H., Ou, C.Q., He, J.X., Clinical characteristics of coronavirus disease 2019 in china (2020) N Engl J Med, , [Epub ahead of print]; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in wuhan (2020) China. Lancet, 395, pp. 497-506; Liu, W., Tao, Z.-W., Lei, W., Ming-Li, Y., Kui, L., Ling, Z., Analysis of factors associated with disease outcomes in hospitalized patients with 2019 novel coronavirus disease (2020) Chin Med J; Yang, X., Yu, Y., Xu, J., Shu, H., Xia, J., Liu, H., Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in wuhan, China: a single-centered, retrospective, observational study (2020) The Lancet Respiratory Medicine, 0 (0); Zhang, J.J., Dong, X., Cao, Y.Y., Yuan, Y.D., Yang, Y.B., Yan, Y.Q., Clinical characteristics of 140 patients infected by SARS-CoV-2 in wuhan, China (2020) Allergy, , [Epub ahead of print]","Lippi, G.; Section of Clinical Biochemistry, University Hospital of Verona, Piazzale LA Scuro, Italy; email: giuseppe.lippi@univr.it",,Elsevier B.V.,9536205,,EJIME,32192856,English,Eur. J. Intern. Med.,Letter,Article in Press,Open Access,Scopus,2-s2.0-85082469236,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Liu X., Wang X.-J.",57212230385;35239172100;,Potential inhibitors against 2019-nCoV coronavirus M protease from clinically approved medicines,2020,Journal of Genetics and Genomics,,,,119,121,,,10.1016/j.jgg.2020.02.001,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082468945&doi=10.1016%2fj.jgg.2020.02.001&partnerID=40&md5=5c685ca1e7334bfcb81ab53e67187613,"Key Laboratory of Genetic Network Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China; University of Chinese Academy of Sciences, Beijing, 100049, China; Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing, 100101, China","Liu, X., Key Laboratory of Genetic Network Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China; Wang, X.-J., Key Laboratory of Genetic Network Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China, University of Chinese Academy of Sciences, Beijing, 100049, China, Innovation Academy for Seed Design, Chinese Academy of Sciences, Beijing, 100101, China",[No abstract available],,,"Anand, K., Ziebuhr, J., Wadhwani, P., Mesters, J.R., Hilgenfeld, R., Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs (2003) Science, 300, pp. 1763-1767; Cui, J., Li, F., Shi, Z.L., Origin and evolution of pathogenic coronaviruses (2019) Nat. Rev. Microbiol., 17, pp. 181-192; Dhama, K., Pawaiya, R., Chakraborty, S., Tiwari, R., Saminathan, M., Verma, A., Coronavirus infection in equines: a review (2014) Asian J. Anim. Vet. Adv., 9, pp. 164-176; Gorbalenya, A.E., Donchenko, A.P., Blinov, V.M., Koonin, E.V., Cysteine proteases of positive strand RNA viruses and chymotrypsin-like serine proteases. A distinct protein superfamily with a common structural fold (1989) FEBS Lett., 243, pp. 103-114; Hui, D.S., E, I.A., Madani, T.A., Ntoumi, F., Kock, R., Dar, O., Ippolito, G., Petersen, E., The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health - the latest 2019 novel coronavirus outbreak in Wuhan, China (2020) Int. J. Infect. Dis., 91, pp. 264-266; Lai, M.M.C., Holmes, K.V., Coronaviridae: the viruses and their replication (2001) Fields Virology, pp. 1163-1179. , D.M. Knipe P.M. Howley Lippincott Williams & Wilkins Philadelphia; Lu, H., Stratton, C.W., Tang, Y.W., Outbreak of pneumonia of unknown etiology in Wuhan China: the mystery and the miracle (2020) J. Med. Virol.; Masters, P.S., Perlman, S., Coronaviridae (2013) Fields Virology, pp. 825-858. , D.M. Knipe P.M. Howley Lippincott Williams & Wilkins Philadelphia; Nukoolkarn, V., Lee, V.S., Malaisree, M., Aruksakulwong, O., Hannongbua, S., Molecular dynamic simulations analysis of ritonavir and lopinavir as SARS-CoV 3CL(pro) inhibitors (2008) J. Theor. Biol., 254, pp. 861-867; van Regenmortel, M.H.V., Fauquet, C.M., Bishop, D.H.L., Carstens, E.B., Estes, M.K., Lemon, S.M., Maniloff, J., Wickner, R.B., Coronaviridae (2000) Virus Taxonomy: Classification and Nomenclature of Viruses. Seventh Report of the International Committee on Taxonomy of Viruses, pp. 835-849. , M.H.V. van Regenmortel C.M. Fauquet D.H.L. Bishop et al. (eds.) Academic Press San Diego; Schoeman, D., Fielding, B.C., Coronavirus envelope protein: current knowledge (2019) Virol. J., 16, p. 69; Xue, X., Yu, H., Yang, H., Xue, F., Wu, Z., Shen, W., Li, J., Rao, Z., Structures of two coronavirus main proteases: implications for substrate binding and antiviral drug design (2008) J. Virol., 82, pp. 2515-2527; Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., Zhao, X., Tan, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N. Engl. J. Med.","Wang, X.-J.; Key Laboratory of Genetic Network Biology, Institute of Genetics and Developmental Biology, Chinese Academy of SciencesChina; email: xjwang@genetics.ac.cn",,Institute of Genetics and Developmental Biology,16738527,,,32173287,English,J. Genet. Genomics,Letter,Article in Press,Open Access,Scopus,2-s2.0-85082468945,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Yassine H.M., Shah Z.",23098797900;57215966303;,"How could artificial intelligence aid in the fight against coronavirus?: An interview with Dr Hadi M Yassine and Dr Zubair Shah by Felicity Poole, Commissioning Editor",2020,Expert Review of Anti-Infective Therapy,,,,,,,,10.1080/14787210.2020.1744275,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082466041&doi=10.1080%2f14787210.2020.1744275&partnerID=40&md5=edce91cf6566457692b377d70b8c5d35,"College of Health and Life Sciences, Hamad Bin Khalifa University (HBKU), Qatar; College of Science and Engineering, Hamad Bin Khalifa University (HBKU), Qatar","Yassine, H.M., College of Health and Life Sciences, Hamad Bin Khalifa University (HBKU), Qatar; Shah, Z., College of Science and Engineering, Hamad Bin Khalifa University (HBKU), Qatar",[No abstract available],artificial intelligence; COVID19; emerging diseases; in-silico; vaccines,,"Harrison, C., Coronavirus puts drug repurposing on the fast track (2020) News in nature biotechnology, , https://www.nature.com/articles/d41587-020-00003-1, Feb, Available from:,. [cited 2020 Mar 11]; Kaltwasser, J., AI could present a new paradigm in epidemiology (2019) Contagion Live, , https://www.contagionlive.com/news/ai-could-present-a-new-paradigm-in-epidemiology, Oct, Available from:,. [cited 2020 Mar 11]; Selvaraj, S., Borkar, D.S., Prasad, V., Media coverage of medical journals: do the best articles make the news? (2014) PLoS One, 9 (1); Schaffer, A.L., Buckley, N.A., Dobbins, T.A., The crux of the matter: did the ABC’s catalyst program change statin use in Australia? (2015) Med J Aust, 202 (11), pp. 591-594; Chow, M.Y.K., Danchin, M., Willaby, H.W., Parental attitudes, beliefs, behaviours and concerns towards childhood vaccinations in Australia: a national online survey (2017) Aust Fam Physician, 46 (3), p. 145; Vosoughi, S., Roy, D., Aral, S., The spread of true and false news online (2018) Science, 359 (6380), pp. 1146-1151","Yassine, H.M.; Research Projects Manager, Associate Professor of Infectious Diseases, Qatar University Biomedical Research Center, QU-NRC, Building H10, Zone 5, Room D101, Qatar; email: hyassine@qu.edu.qa",,Taylor and Francis Ltd,14787210,,ERATC,,English,Expert Rev. Anti-Infect. Ther.,Note,Article in Press,,Scopus,2-s2.0-85082466041,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Middleton J., Martin-Moreno J.M., Barros H., Chambaud L., Signorelli C.",7202764319;57215968744;57208461574;6603031499;7005736295;,ASPHER statement on the novel coronavirus disease (COVID-19) outbreak emergency,2020,International Journal of Public Health,,,,,,,,10.1007/s00038-020-01362-x,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082465212&doi=10.1007%2fs00038-020-01362-x&partnerID=40&md5=95fcc09f49a25dabb68aa4d03fda63ac,"Association of Schools of Public Health in the European Region - ASPHER, Brussels, Belgium; ASPHER Honours Committee, University of Valencia, Valencia, Spain; Institute of Public Health, University of Porto, Porto, Portugal; EHESP School of Public Health, Rennes, France; School of Public Health, Vita-Salute San Raffaele University, Milan, Italy","Middleton, J., Association of Schools of Public Health in the European Region - ASPHER, Brussels, Belgium; Martin-Moreno, J.M., ASPHER Honours Committee, University of Valencia, Valencia, Spain; Barros, H., Institute of Public Health, University of Porto, Porto, Portugal; Chambaud, L., EHESP School of Public Health, Rennes, France; Signorelli, C., School of Public Health, Vita-Salute San Raffaele University, Milan, Italy",[No abstract available],,,,"Middleton, J.; Association of Schools of Public Health in the European Region - ASPHERBelgium; email: john.middleton@aspher.org",,Springer,16618556,,,,English,Int. J. Public Health,Editorial,Article in Press,Open Access,Scopus,2-s2.0-85082465212,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Lu D., Wang H., Yu R., Yang H., Zhao Y.",57196940777;57215965928;57215965269;57192952066;57215901718;,Integrated infection control strategy to minimize nosocomial infection of coronavirus disease 2019 among ENT healthcare workers,2020,Journal of Hospital Infection,,,,,,,,10.1016/j.jhin.2020.02.018,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082464759&doi=10.1016%2fj.jhin.2020.02.018&partnerID=40&md5=4d89617247984b7c8ab59e77884bcce3,"Department of Otorhinolaryngology, Head & Neck Surgery, West China Hospital, Sichuan UniversitySichuan, China","Lu, D., Department of Otorhinolaryngology, Head & Neck Surgery, West China Hospital, Sichuan UniversitySichuan, China; Wang, H., Department of Otorhinolaryngology, Head & Neck Surgery, West China Hospital, Sichuan UniversitySichuan, China; Yu, R., Department of Otorhinolaryngology, Head & Neck Surgery, West China Hospital, Sichuan UniversitySichuan, China; Yang, H., Department of Otorhinolaryngology, Head & Neck Surgery, West China Hospital, Sichuan UniversitySichuan, China; Zhao, Y., Department of Otorhinolaryngology, Head & Neck Surgery, West China Hospital, Sichuan UniversitySichuan, China",[No abstract available],,,"Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395, pp. 507-513; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan (2020) China. Lancet, 395, pp. 497-506; Lu, H., Stratton, C.W., Tang, Y.W., Outbreak of pneumonia of unknown etiology in Wuhan, China: the mystery and the miracle (2020) J Med Virol, 92, pp. 401-402; Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med, , [Epub ahead of print]; Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) JAMA, , [Epub ahead of print]; Guan, W., Ni, Z., Hu, Y., Liang, W., Ou, C., He, J., Clinical characteristics of 2019 novel coronavirus infection in China (2020) N Engl J Med, , [Epub ahead of print]","Yang, H.No. 37 Guo Xue Xiang, Wu Hou District, China; email: yh8806@163.com",,W.B. Saunders Ltd,1956701,,JHIND,32114056,English,J. Hosp. Infect.,Letter,Article in Press,Open Access,Scopus,2-s2.0-85082464759,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Gherghel I., Bulai M.",26429389200;55175571200;,Is Romania ready to face the novel coronavirus (COVID-19) outbreak? The role of incoming travelers and that of Romanian diaspora,2020,Travel Medicine and Infectious Disease,,,101628,,,,,10.1016/j.tmaid.2020.101628,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082461550&doi=10.1016%2fj.tmaid.2020.101628&partnerID=40&md5=cfae1047d6e9408da36fe9acf379fa6c,"Department of Biology, Case Western Reserve University, 2080 Adelbert Road, Cleveland, OH 44106, United States; Faculty of Geography and Geology, Alexandru Ioan Cuza University of Iași, Carol 1 Boulevard, No. 20A, Iași, 700505, Romania","Gherghel, I., Department of Biology, Case Western Reserve University, 2080 Adelbert Road, Cleveland, OH 44106, United States, Faculty of Geography and Geology, Alexandru Ioan Cuza University of Iași, Carol 1 Boulevard, No. 20A, Iași, 700505, Romania; Bulai, M., Faculty of Geography and Geology, Alexandru Ioan Cuza University of Iași, Carol 1 Boulevard, No. 20A, Iași, 700505, Romania",[No abstract available],,,"Rodríguez-Morales, A.J., MacGregor, K., Kanagarajah, S., Patel, D., Schlagenhauf, P., Going global – travel and the 2019 novel coronavirus (2020) Trav Med Infect Dis, 33; Pullano, G., Pinotti, F., Valdano, E., Boëlle, P.-Y., Poletto, C., Colizza, V., Novel coronavirus (2019-nCoV) early-stage importation risk to Europe, January 2020 (2020) Euro Surveill, 25 (4), p. 2000057; Vlădescu, C., Scîntee, S.G., Olsavszky, V., Hernández-Quevedo, C., Sagan, A., Romania: health system review (2016), World Health Organization, on behalf of the European Observatory on Health Copenhagen, Denmark; Instabilitate guvernamentală cronică, Cifrele care arată de ce România are una dintre cele mai ridicate instabilități guvernamentale europene, în ultimii 27 de ani (2017), Center for the Promotion of Participation and of Democracy. National University of Political Studies and Public Administration Bucharest, Romania; (2020) Comitetul interministerial pentru monitorizarea și managementul potențialelor infecții cu noul coronavirus, , Romanian Ministery of Health Bucharest, Romania; Xie, X., Zhong, Z., Zhao, W., Zheng, C., Wang, F., Liu, J., Chest CT for typical 2019-nCoV pneumonia: relationship to negative RT-PCR testing (2020) Radiology","Gherghel, I.; Department of Biology, Case Western Reserve University, 2080 Adelbert Road, United States; email: iuliangherghel@case.edu",,Elsevier USA,14778939,,TMIDA,32184128,English,Travel Med. Infect. Dis.,Letter,Article in Press,Open Access,Scopus,2-s2.0-85082461550,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wang J., Zhou M., Liu F.",57193687279;57213827481;57201582388;,Reasons for healthcare workers becoming infected with novel coronavirus disease 2019 (COVID-19) in China,2020,Journal of Hospital Infection,,,,,,,,10.1016/j.jhin.2020.03.002,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082460773&doi=10.1016%2fj.jhin.2020.03.002&partnerID=40&md5=278242c860a2eb1d13f8cc5dc82ffe70,"Institute of Global Health, Faculty of Medicine, University of Geneva, Geneva, Switzerland; Dong Guan Nosocomial Infection Control and Quality Improvement Centre, Dongguan City, Guangdong Province, China","Wang, J., Institute of Global Health, Faculty of Medicine, University of Geneva, Geneva, Switzerland; Zhou, M., Dong Guan Nosocomial Infection Control and Quality Improvement Centre, Dongguan City, Guangdong Province, China; Liu, F., Institute of Global Health, Faculty of Medicine, University of Geneva, Geneva, Switzerland",[No abstract available],,,"Coronavirus disease (COVID-19) outbreak (2020), https://www.who.int/emergencies/diseases/novel-coronavirus-2019, Available at: [last accessed February 2020]; (2020) Coronavirus COVID-19 global cases by Johns Hopkins CSSE, , https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6, Available at: [last accessed February 2020]; Wang, J., Liu, F., Tan, J.B.X., Harbarth, S., Pittet, D., Zingg, W., Implementation of infection prevention and control in acute care hospitals in Mainland China – a systematic review (2019) Antimicrob Resist Infect Control, 8, p. 32; Chang, D., Xu, H., Rebaza, A., Sharma, L., Dela Cruz, C.S., Protecting health-care workers from subclinical coronavirus infection (2020) Lancet Respir Med, , [Epub ahead of print]; Improved governance and China's exploration provides important inspiration (2020), http://paper.people.com.cn/rmrb/html/2020-02/25/nw.D110000renmrb_20200225_2-04.htm, [in Chinese] Available at: [last accessed February 2020]; Information on the distribution of healthcare workers in Guangdong medical support teams (2020), https://new.qq.com/omn/20200224/20200224A02ELP00.html, [in Chinese] Available at: [last accessed February 2020]; Wu, A., Huang, X., Li, C., Li, L., Novel coronavirus (2019-nCov) pneumonia in medical institutions: problems in prevention and control (2020) Chin J Infect Control, 19, pp. 1-6. , [in Chinese]; Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19) (2020), https://www.who.int/docs/default-source/coronaviruse/who-china-joint-mission-on-covid-19-final-report.pdf, Available at: [last accessed March 2020]; Rational, scientific, and standardized protection: the core of infection prevention and control of COVID-19 in medical institutions (2020), https://mp.weixin.qq.com/s/G5Nwdd9kW9yVD-hTdwsKtg, [in Chinese] Available at: [last accessed February 2020]","Wang, J.; Université de Genève Faculté de Médecine, Institute of Global Health, University of GenevaSwitzerland; email: jiancong.wang@outlook.com",,W.B. Saunders Ltd,1956701,,JHIND,32147406,English,J. Hosp. Infect.,Letter,Article in Press,Open Access,Scopus,2-s2.0-85082460773,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Lillie P.J., Samson A., Li A., Adams K., Capstick R., Barlow G.D., Easom N., Hamilton E., Moss P.J., Evans A., Ivan M., PHE Incident Team, Taha Y., Duncan C.J.A., Schmid M.L., the Airborne HCID Network",25823206800;57215542563;57215966202;7201820646;57215963915;55523277900;6507453984;57215972177;7103406216;57215969481;57209756965;57215963323;57200424165;36551060800;57215966779;57215963437;,Novel coronavirus disease (Covid-19): The first two patients in the UK with person to person transmission,2020,Journal of Infection,,,,,,,,10.1016/j.jinf.2020.02.020,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082460492&doi=10.1016%2fj.jinf.2020.02.020&partnerID=40&md5=12a7a393cff307b1d097151cd975b60a,"Department of Infection, Hull University Teaching Hospitals NHS Trust, Hull, United Kingdom; Department of Infection and Tropical Medicine, The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom; Hull York Medical School, University of York, United Kingdom; PHE Incident Team, Public Health England, National Infection Service, London, NW9 5EQ, United Kingdom; Translational and Clinical Research Institute, Immunity and Inflammation Theme, Newcastle University, United Kingdom; Airborne HCID Network, United Kingdom","Lillie, P.J., Department of Infection, Hull University Teaching Hospitals NHS Trust, Hull, United Kingdom; Samson, A., Department of Infection, Hull University Teaching Hospitals NHS Trust, Hull, United Kingdom; Li, A., Department of Infection and Tropical Medicine, The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom; Adams, K., Department of Infection, Hull University Teaching Hospitals NHS Trust, Hull, United Kingdom; Capstick, R., Department of Infection and Tropical Medicine, The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom; Barlow, G.D., Department of Infection, Hull University Teaching Hospitals NHS Trust, Hull, United Kingdom, Hull York Medical School, University of York, United Kingdom; Easom, N., Department of Infection, Hull University Teaching Hospitals NHS Trust, Hull, United Kingdom; Hamilton, E., Department of Infection and Tropical Medicine, The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom; Moss, P.J., Department of Infection, Hull University Teaching Hospitals NHS Trust, Hull, United Kingdom; Evans, A., Department of Infection and Tropical Medicine, The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom; Ivan, M., Department of Infection, Hull University Teaching Hospitals NHS Trust, Hull, United Kingdom; PHE Incident Team, PHE Incident Team, Public Health England, National Infection Service, London, NW9 5EQ, United Kingdom; Taha, Y., Department of Infection and Tropical Medicine, The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom; Duncan, C.J.A., Department of Infection and Tropical Medicine, The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom, Translational and Clinical Research Institute, Immunity and Inflammation Theme, Newcastle University, United Kingdom; Schmid, M.L., Department of Infection and Tropical Medicine, The Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom; the Airborne HCID Network, Airborne HCID Network, United Kingdom",[No abstract available],,,"Tang, J.W., Tambyah, P.A., Hui, D.S.C., Emergence of a novel coronavirus causing respiratory illness from Wuhan, China (2020) J Infect, , published online Jan 27; Q, L.I., An outbreak of NCIP (SARS-CoV-2) infection in China — Wuhan, Hubei province, 2019−2020 (2020) CCDC Weekly, 2, pp. 80-81; Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, , published online Jan 24; Chan, J.F.-W., Yuan, S., Kok, K.-H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, 395, pp. 514-523; Li, Q., Guan, X., Wu, P., Early transmission dynamics in wuhan, china, of novel coronavirus–infected pneumonia (2020) N Engl J Med, , published online Jan 29; Phan, L.T., Nguyen, T.V., Luong, Q.C., Importation and human-to-human transmission of a novel coronavirus in Vietnam (2020) N Engl J Med, , published online Jan 28; Rothe, C., Schunk, M., Sothmann, P., Transmission of SARS-CoV-2 infection from an asymptomatic contact in Germany (2020) N Engl J Med, , published online Jan 30; Holshue, M.L., DeBolt, C., Lindquist, S., First case of 2019 novel coronavirus in the United States (2020) N Engl J Med, , published online Jan 31; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) The Lancet, 395, pp. 497-506; (2020), www.gov.uk/government/publications/wuhan-novel-coronavirus-infection-prevention-and-control/wuhan-novel-coronavirus-wn-cov-infection-prevention-and-control-guidance, Novel coronavirus (SARS-CoV-2) infection prevention and control guidance. Public Health England. Accessed 3rd February","Duncan, C.J.A.; Department of Infection and Tropical Medicine, The Newcastle Upon Tyne Hospitals NHS Foundation TrustUnited Kingdom; email: christopher.duncan@ncl.ac.uk",,W.B. Saunders Ltd,1634453,,JINFD,32119884,English,J. Infect.,Letter,Article in Press,Open Access,Scopus,2-s2.0-85082460492,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Yasri S., Wiwanitkit V.",56022182600;55628572491;,Tuberculosis and novel Wuhan coronavirus infection: Pathological interrelationship,2020,Indian Journal of Tuberculosis,,,,,,,,10.1016/j.ijtb.2020.02.004,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082457146&doi=10.1016%2fj.ijtb.2020.02.004&partnerID=40&md5=5650c5b1e53d64886ec288c8495e687f,"KMT Primary Medical Center, Bangkok, Thailand; Dr DY Patil University, Pune, India","Yasri, S., KMT Primary Medical Center, Bangkok, Thailand; Wiwanitkit, V., Dr DY Patil University, Pune, India",[No abstract available],,,"Hsia, W., Emerging new coronavirus infection in Wuhan, China: situation in early 2020 (2020) Case Stud Case Rep, 10, pp. 8-9; Yasri, S., Wiwanitkit, V., Editorial: Wuhan coronavirus outbreak and imported case (2020) Adv Trop Med Public Health Int, 10, pp. 1-2","Yasri, S.; KMT Primary Medical CenterThailand; email: sorayasri@outlook.co.th",,Tuberculosis Association of India,195707,,IJTBA,,English,Indian J. Tuberc.,Letter,Article in Press,Open Access,Scopus,2-s2.0-85082457146,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Lippi G., Lavie C.J., Sanchis-Gomar F.",57205413642;57216061700;35103550200;,Cardiac troponin I in patients with coronavirus disease 2019 (COVID-19): Evidence from a meta-analysis,2020,Progress in Cardiovascular Diseases,,,,,,,,10.1016/j.pcad.2020.03.001,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082447816&doi=10.1016%2fj.pcad.2020.03.001&partnerID=40&md5=9da62eebf96ccd41a61819e2c03df6e0,"Section of Clinical Biochemistry, Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy; John Ochsner Heart and Vascular Institute, Ochsner Clinical School - The University of Queensland School of Medicine, New Orleans, LA, United States; Department of Physiology, Faculty of Medicine, University of Valencia and INCLIVA Biomedical Research Institute, Valencia, Spain; Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, United States","Lippi, G., Section of Clinical Biochemistry, Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy; Lavie, C.J., John Ochsner Heart and Vascular Institute, Ochsner Clinical School - The University of Queensland School of Medicine, New Orleans, LA, United States; Sanchis-Gomar, F., Department of Physiology, Faculty of Medicine, University of Valencia and INCLIVA Biomedical Research Institute, Valencia, Spain, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, United States",[No abstract available],Coronavirus; COVID-19; Prognosis; Troponin,,"World Health Organization, Coronavirus disease 2019 (COVID-19) situation report – 44 https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports/, Available at: (Accessed 5 March 2020); Mattiuzzi, C., Lippi, G., Which lessons shall we learn from the 2019 novel coronavirus outbreak? (2020) Ann Transl Med., 8 (3), p. 48; Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19) (2020), https://www.who.int/docs/default-source/coronaviruse/who-china-joint-mission-on-covid-19-final-report.pdf, Available at: (Accessed 5 March 2020); Corrales-Medina, V.F., Suh, K.N., Rose, G., Cardiac complications in patients with community-acquired pneumonia: a systematic review and meta-analysis of observational studies (2011) PLoS Med, 8; Hozo, S.P., Djulbegovic, B., Hozo, I., Estimating the mean and variance from the median, range, and the size of a sample (2005) BMC Med Res Methodol, 5, p. 13; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395 (10223), pp. 497-506; Liu, Y., Yang, Y., Zhang, C., Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury (2020) Sci China Life Sci, 63 (3), pp. 364-374; Wang, D., Hu, B., Hu, C., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) JAMA; Ruan, Q., Yang, K., Wang, W., Jiang, L., Song, J., Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China (2020) Intensive Care Med; Lippi, G., Plebani, M., Laboratory abnormalities in patients with COVID-2019 infection (2020) Clin Chem Lab Med","Sanchis-Gomar, F.; Department of Physiology, Faculty of Medicine, University of Valencia, Av. Blasco Ibañez, 15, Spain; email: fabian.sanchis@uv.es",,W.B. Saunders,330620,,PCVDA,32169400,English,Prog. Cardiovasc. Dis.,Letter,Article in Press,Open Access,Scopus,2-s2.0-85082447816,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Bonow R.O., Fonarow G.C., O'Gara P.T., Yancy C.W.",7102250069;7004451284;7005069547;7003657960;,Association of Coronavirus Disease 2019 (COVID-19) with Myocardial Injury and Mortality,2020,JAMA Cardiology,,,,,,,,10.1001/jamacardio.2020.1105,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082436892&doi=10.1001%2fjamacardio.2020.1105&partnerID=40&md5=30659ffbf5bc3c4d1e0e5311280941e7,"Northwestern University Feinberg School of Medicine, 676 N St. Clair St, Chicago, IL 60611, United States; JAMA Cardiology; Ahmanson-UCLA Cardiomyopathy Center, David Geffen School of Medicine at UCLA, University of California, Los Angeles, United States; Health Care Quality and Guidelines, JAMA Cardiology; Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, United States; JAMA Cardiology","Bonow, R.O., Northwestern University Feinberg School of Medicine, 676 N St. Clair St, Chicago, IL 60611, United States, JAMA Cardiology; Fonarow, G.C., Ahmanson-UCLA Cardiomyopathy Center, David Geffen School of Medicine at UCLA, University of California, Los Angeles, United States, Health Care Quality and Guidelines, JAMA Cardiology; O'Gara, P.T., Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, United States, JAMA Cardiology; Yancy, C.W., Northwestern University Feinberg School of Medicine, 676 N St. Clair St, Chicago, IL 60611, United States, JAMA Cardiology",[No abstract available],,,"Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395 (10223), pp. 497-506. , http://dx.doi.org/10.1016/S0140-6736(20)30183-5, doi: PMID 31986264; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study (2020) Lancet, 395 (10223), pp. 507-513. , http://dx.doi.org/10.1016/S0140-6736(20)30211-7, doi: PMID 32007143; Wang, D., Hu, B., Hu, C., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) JAMA, 323 (11), pp. 1061-1069. , http://jamanetwork.com/article.aspx?doi=10.1001/jama.2020.1585, doi: PMID 32031570; Wu, Z., McGoogan, J.M., Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention (2020) JAMA, , http://jamanetwork.com/article.aspx?doi=10.1001/jama.2020.2648, Published online February 24, doi: PMID 32091533; Guan, W.J., Ni, Z.Y., Hu, Y., Clinical characteristics of coronavirus disease 2019 in China (2020) N Engl J Med, , http://dx.doi.org/10.1056/NEJMoa2002032, Published online February 28, doi: PMID 32109013; Madjid, M., Miller, C.C., Zarubaev, V.V., Influenza epidemics and acute respiratory disease activity are associated with a surge in autopsy-confirmed coronary heart disease death: Results from 8 years of autopsies in 34,892 subjects (2007) Eur Heart J, 28 (10), pp. 1205-1210. , http://dx.doi.org/10.1093/eurheartj/ehm035, doi: PMID 17440221; Nguyen, J.L., Yang, W., Ito, K., Matte, T.D., Shaman, J., Kinney, P.L., Seasonal influenza infections and cardiovascular disease mortality (2016) JAMA Cardiol, 1 (3), pp. 274-281. , http://jamanetwork.com/article.aspx?doi=10.1001/jamacardio.2016.0433, doi: PMID 27438105; Kwong, J.C., Schwartz, K.L., Campitelli, M.A., Acute myocardial infarction after laboratory-confirmed influenza infection (2018) N Engl J Med, 378 (4), pp. 345-353. , http://dx.doi.org/10.1056/NEJMoa1702090, doi: PMID 29365305; Smeeth, L., Thomas, S.L., Hall, A.J., Hubbard, R., Farrington, P., Vallance, P., Risk of myocardial infarction and stroke after acute infection or vaccination (2004) N Engl J Med, 351 (25), pp. 2611-2618. , http://dx.doi.org/10.1056/NEJMoa041747, doi: PMID 15602021; Shi, S., Qin, M., Shen, B., Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China (2020) JAMA Cardiol, , http://jamanetwork.com/article.aspx?doi=10.1001/jamacardio.2020.0950, Published online March 25; Guo, T., Fan, Y., Chen, M., Cardiovascular implications of fatal outcomes of patients with coronavirus disease 2019 (COVID-19) (2020) JAMA Cardiol, , http://jamanetwork.com/article.aspx?doi=10.1001/jamacardio.2020.1017, Published online March 27; Yang, C., Jin, Z., An acute respiratory infection runs into the most common noncommunicable epidemic - COVID-19 and cardiovascular diseases (2020) JAMA Cardiol, , http://jamanetwork.com/article.aspx?doi=10.1001/jamacardio.2020.0934, Published online March 25; Oudit, G.Y., Kassiri, Z., Jiang, C., SARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS (2009) Eur J Clin Invest, 39 (7), pp. 618-625. , http://dx.doi.org/10.1111/j.1365-2362.2009.02153.x, doi: PMID 19453650; Zheng, Y.Y., Ma, Y.T., Zhang, J.Y., Xie, X., COVID-19 and the cardiovascular system (2020) Nat Rev Cardiol, , http://dx.doi.org/10.1038/s41569-020-0360-5, Published online March 5, doi: PMID 32139904; Inciardi, R.M., Lupi, L., Zaccone, G., Cardiac involvement in a patient with coronavirus disease 2019 (COVID-19) (2020) JAMA Cardiol, , http://jamanetwork.com/article.aspx?doi=10.1001/jamacardio.2020.1096, Published online March 27; Madjid, M., Safavi-Naeini, P., Solomon, S.D., Vardeny, O., Potential effects of coronaviruses on the cardiovascular system: A review (2020) JAMA Cardiol, , http://jamanetwork.com/article.aspx?doi=10.1001/jamacardio.2020.1286, Published online March 27","Bonow, R.O.; Northwestern University Feinberg School of Medicine, 676 N St. Clair St, United States; email: robert.bonow@nm.org",,American Medical Association,23806583,,,32219362,English,JAMA Cardiol.,Editorial,Article in Press,Open Access,Scopus,2-s2.0-85082436892,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Lee I.-K., Wang C.-C., Lin M.-C., Kung C.-T., Lan K.-C., Lee C.-T.",57215962395;55766694000;57215967153;57215967827;57215964758;57215967223;,Effective strategies to prevent coronavirus disease-2019 (COVID-19) outbreak in hospital,2020,Journal of Hospital Infection,,,,,,,,10.1016/j.jhin.2020.02.022,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082436203&doi=10.1016%2fj.jhin.2020.02.022&partnerID=40&md5=54b0e994652ac1458d6b0435f7b08e9b,"Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Taiwan; Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University Medical College, Tao-Yuan, 330, Taiwan; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Taiwan; Department of Emergency, Kaohsiung Chang Gung Memorial Hospital, Taiwan; Department of Gynecology and Obstetrics, Kaohsiung Chang Gung Memorial Hospital, Taiwan; Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Taiwan","Lee, I.-K., Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Taiwan; Wang, C.-C., Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University Medical College, Tao-Yuan, 330, Taiwan; Lin, M.-C., Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Taiwan; Kung, C.-T., Department of Emergency, Kaohsiung Chang Gung Memorial Hospital, Taiwan; Lan, K.-C., Department of Gynecology and Obstetrics, Kaohsiung Chang Gung Memorial Hospital, Taiwan; Lee, C.-T., Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Taiwan",[No abstract available],,,"Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382, pp. 727-733; Taiwan Centers for Disease Control, Novel coronavirus 2019-nCoV outbreak https://www.cdc.gov.tw, Available at: [last accessed February 2020]; Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) JAMA, , [Epub ahead of print]; Zou, L., Ruan, F., Huang, M., Liang, L., Huang, H., Hong, Z., SARS-CoV-2 viral load in upper respiratory specimens of infected patients (2020) N Engl J Med, , [Epub ahead of print]; Liu, J.W., Lu, S.N., Chen, S.S., Yang, K.D., Lin, M.C., Wu, C.C., Epidemiologic study and containment of a nosocomial outbreak of severe acute respiratory syndrome in a medical center in Kaohsiung, Taiwan (2006) Infect Control Hosp Epidemiol, 27, pp. 466-472; World Health Organization, Coronavirus disease (COVID-2019) situation reports. Situation report – 33 https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports/, Available at: [last accessed February 2020]; Mahase, E., Coronavirus covid-19 has killed more people than SARS and MERS combined, despite lower case fatality rate (2020) BMJ, 368, p. m641; Wang, C., Horby, P.W., Hayden, F.G., Gao, G.F., A novel coronavirus outbreak of global health concern (2020) Lancet, 395, pp. 470-473","Wang, C.-C.; Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, 123, Ta-Pei Road, Niao-Song, Taiwan; email: ufel4996@ms26.hinet.net",,W.B. Saunders Ltd,1956701,,JHIND,32142886,English,J. Hosp. Infect.,Letter,Article in Press,Open Access,Scopus,2-s2.0-85082436203,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Abdi M.,57211532223;,Coronavirus disease 2019 (COVID-19) outbreak in Iran; Actions and problems,2020,Infection Control and Hospital Epidemiology,,,,,,,,10.1017/ice.2020.86,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082434746&doi=10.1017%2fice.2020.86&partnerID=40&md5=c05c379a42b271bdfbad6c114f9fcd3a,"Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran; Department of Microbiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran","Abdi, M., Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran, Department of Microbiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran",[No abstract available],,,"(2020), https://www.who.int/health-topics/coronavirus, Organization WH, Coronavirus: WHO;; (2020) Coronavirus Disease 2019 (COVID-19) Situation Summary: Centers for Disease Control and Prevention, , https://www.cdc.gov/coronavirus/2019-nCoV/summary.html, National Center for Immunization and Respiratory Diseases (NCIRD) DoVD; (2020), http://behdasht.gov.ir/, Education MoHaM; http://behdasht.gov.ir/index.jsp?siteid=1&fkeyid=&siteid=1&pageid=54782&newsview=200401, Education MoHaM, Identification of 743 cases of definitive new infections with Covid in the country MHME2020; (2020), http://dme.behdasht.gov.ir/index.aspx?siteid=1&pageid=3127, Center NaI. Online news: Ministry of Health and Medical Education;; Gardner, L., (2020) Mapping 2019-nCoV: John's Hopkins University, , https://systems.jhu.edu/research/public-health/ncov/; Dong, E., Du, H., Gardner, L., An interactive web-based dashboard to track COVID-19 in real time (2020) The Lancet Infectious Diseases; (2020) Coronavirus Disease (COVID-19) Advice for the Public: WHO, , https://www.who.int/emergencies/diseases/novel-coronavirus-2019/advice-for-public, Organization WH; National Committee to Combat Corona Meeting 2020, , http://www.president.ir/fa/114157, Database PsI","Abdi, M.; Department of Microbiology, Faculty of Medicine, Iran University of Medical SciencesIran; email: miladabdi1369@gmail.com",,Cambridge University Press,0899823X,,ICEPE,32192541,English,Infect. Control Hosp. Epidemiol.,Letter,Article in Press,Open Access,Scopus,2-s2.0-85082434746,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Leng Z., Yin D., Zhao Z., Yan M., Yang Y., He X., Zhao R.C., Liu H.",57215865829;57215934689;57215932452;57215933017;57215938169;7404407957;57215933719;57201740523;,A survey of 434 clinical trials about coronavirus disease 2019 in China,2020,Journal of Medical Virology,,,,,,,,10.1002/jmv.25779,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082434177&doi=10.1002%2fjmv.25779&partnerID=40&md5=45ca7fb19bb4160a03e9b11fa85d6363,"Department of Orthopaedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Orthopaedics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China; Department of Cell Biology, School of Life Sciences, Shanghai University, Shanghai, China","Leng, Z., Department of Orthopaedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Yin, D., Department of Orthopaedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Zhao, Z., Department of Orthopaedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Yan, M., Department of Orthopaedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Yang, Y., Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; He, X., Department of Orthopaedics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China; Zhao, R.C., Department of Cell Biology, School of Life Sciences, Shanghai University, Shanghai, China; Liu, H., Department of Orthopaedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China",[No abstract available],,,"Wang, D., Hu, B., Hu, C., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) JAMA, 323, p. 1061; Holshue, M.L., DeBolt, C., Lindquist, S., First case of 2019 novel coronavirus in the United States (2020) N Engl J Med, 382 (10), pp. 929-936; Chan, A.-W., Tetzlaff, J.M., Altman, D.G., SPIRIT 2013 statement: defining standard protocol items for clinical trials (2013) Ann Intern Med, 158 (3), pp. 200-207; Lu, R., Zhao, X., Li, J., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet, 395, pp. 565-574; Munster, V.J., Koopmans, M., van Doremalen, N., van Riel, D., de Wit, E., A novel coronavirus emerging in China—key questions for impact assessment (2020) N Engl J Med, 382, pp. 692-694; Leng, Z., Zhu, R., Hou, W., Georgina Ellison-Hughes, Calogero Caruso, Kunlin Jin, Robert Chunhua Zhao. Transplantation of ACE2-mesenchymal stem cells improves the outcome of patients with COVID-19 pneumonia (2020) Aging Dis, 11 (2), pp. 216-228; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506","Liu, H.; Department of Orthopaedics, The First Affiliated Hospital of Zhengzhou UniversityChina; email: hongjianmd@126.com",,John Wiley and Sons Inc.,1466615,,JMVID,,English,J. Med. Virol.,Letter,Article in Press,,Scopus,2-s2.0-85082434177,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Chan J.Y.K., Wong E.W.Y., Lam W.",57200278898;57215933644;57196356986;,Practical Aspects of Otolaryngologic Clinical Services during the 2019 Novel Coronavirus Epidemic: An Experience in Hong Kong,2020,JAMA Otolaryngology - Head and Neck Surgery,,,,,,,,10.1001/jamaoto.2020.0488,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082433944&doi=10.1001%2fjamaoto.2020.0488&partnerID=40&md5=596a8d74c193fc10f572dd14836798f2,"Department of Otorhinolaryngology, Head and Neck Surgery, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong; Division of Urology, Department of Surgery, University of Hong Kong, Pok Fu Lam, Hong Kong","Chan, J.Y.K., Department of Otorhinolaryngology, Head and Neck Surgery, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong; Wong, E.W.Y., Department of Otorhinolaryngology, Head and Neck Surgery, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong; Lam, W., Division of Urology, Department of Surgery, University of Hong Kong, Pok Fu Lam, Hong Kong",[No abstract available],,,"Wu, J.T., Leung, K., Leung, G.M., Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating inWuhan, China: A modelling study (2020) Lancet., 395, pp. 689-697. , 10225; Wang, D., Hu, B., Hu, C., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) Jama, , Published online February 7; Chan, P.K., Ip, M., Ng, K.C., Severe acute respiratory syndrome-associated coronavirus infection (2003) Emerg Infect Dis., 9 (11), pp. 1453-1454; Drosten, C., Günther, S., Preiser, W., Identification of a novel coronavirus in patients with severe acute respiratory syndrome (2003) N Engl J Med., 348 (20), pp. 1967-1976; (2020) Recommended Personal Protective Equipment (PPE) in Hospitals/clinics under Serious/ Emergency Response Level., , https://www.chp.gov.hk/files/pdf/recommended_ppe_for_nid_eng.pdf, Centre for Health Protection Accessed February 8; Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med., , Published online January 29","Chan, J.Y.K.; Department of Otorhinolaryngology, Head and Neck Surgery, Chinese University of Hong Kong, Prince of Wales HospitalHong Kong; email: jasonchan@ent.cuhk.edu.hk",,American Medical Association,21686181,,,32196070,English,JAMA Otolaryngol. Head Neck Surg.,Note,Article in Press,Open Access,Scopus,2-s2.0-85082433944,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Rahimi F., Talebi Bezmin Abadi A.",6603731766;57194487001;,Practical Strategies Against the Novel Coronavirus and COVID-19—the Imminent Global Threat,2020,Archives of Medical Research,,,,,,,,10.1016/j.arcmed.2020.03.005,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082433274&doi=10.1016%2fj.arcmed.2020.03.005&partnerID=40&md5=7c5a9223bed6681bd0c30d6edad21514,"Research School of Biology, The Australian National University, Canberra, Australia; Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran","Rahimi, F., Research School of Biology, The Australian National University, Canberra, Australia; Talebi Bezmin Abadi, A., Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran","The last month of 2019 harbingered the emergence of a viral outbreak that is now a major public threat globally. COVID-19 was first diagnosed and confirmed in a couple of cases with unknown pneumonia; the patients lived in, or travelled to, Wuhan, the capital of China's Hubei province. People now face a complex challenge that deserves urgent intervention by all involved in medical healthcare globally. Conventional antiviral therapies or vaccines are the most referred means of tackling the virus, but we think establishing these ideal management strategies is presently far-fetched. In-house isolation or quarantine of suspected cases to keep hospital admissions manageable and prevent in-hospital spread of the virus, and promoting general awareness about transmission routes are the practical strategies used to tackle the spread of COVID-19. Cases with weakened or compromised immune systems—for example, elderly individuals, young children, and those with pre-existing conditions such as diabetes, cancer, hypertension, and chronic respiratory diseases—are particularly more susceptible to COVID-19. Hopefully, cumulative data using whole-genome sequencing of the SARS-CoV-2 genome in parallel with mathematical modeling will help the molecular biologists to understand unknown features of the pathogenesis and epidemiology of COVID-19. © 2020 IMSS",Coronaviridae; COVID-19; Pandemic; Prevention; WHO; Wuhan,,"Sun, P., Lu, X., Xu, C., Understanding of COVID-19 based on current evidence (2020) J Med Virol; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506; Imai, N., Dorigatti, I., Cori, A., Imperial College London. Report 2: estimating the potential total number of novel coronavirus cases in Wuhan City, China (2020), https://www.imperial.ac.uk/mrc-globalinfectiousdisease-analysis/news–wuhan-coronavirus. 2020, (Accessed 26 February 2020); Situation Report – 37 (2020), https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200226-sitrep-37-covid-19.pdf, (Accessed 26 February 2020); Duddu, P., Coronavirus: Covid-19 UK outbreak, measures and impact (2020), https://www.pharmaceutical-technology.com/features/coronavirus-affected-uk-ncov-measures-impact, (Accessed 4 March 2020); Coronavirus disease 2019 (COVID-19) Situation Report – 43 (2020), https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200303-sitrep-43-covid-19.pdf?sfvrsn=76e425ed_2, (Accessed 3 March 2020); Wang, M., Cao, R., Zhang, L., Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro (2020) Cell Res, 30, pp. 269-271; Heymann, D.L., Shindo, N., COVID-19: what is next for public health? (2020) Lancet, 395, pp. 542-545; Olena, A., Newer Vaccine Technologies Deployed to Develop COVID-19 Shot (2020), https://www.the-scientist.com/news-opinion/newer-vaccine-technologies-deployed-to-develop-covid-19-shot-67152, (Accessed 21 February 2020)","Talebi Bezmin Abadi, A.; Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, P.O. Box 14115-111, Iran; email: Amin.talebi@modares.ac.ir",,Elsevier Inc.,1884409,,AEDEE,,English,Arch. Med. Res.,Article,Article in Press,,Scopus,2-s2.0-85082433274,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Henry B.M., Lippi G.",56689347500;57215931367;,Chronic kidney disease is associated with severe coronavirus disease 2019 (COVID-19) infection,2020,International Urology and Nephrology,,,,,,,,10.1007/s11255-020-02451-9,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082427357&doi=10.1007%2fs11255-020-02451-9&partnerID=40&md5=4f39223409a34b4571064645fca976bc,"Cardiac Intensive Care Unit, The Heart Institute, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, United States; Section of Clinical Biochemistry, Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy","Henry, B.M., Cardiac Intensive Care Unit, The Heart Institute, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229, United States; Lippi, G., Section of Clinical Biochemistry, Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy",[No abstract available],,,"Chou, C.-Y., Wang, S.-M., Liang, C.-C., Risk of pneumonia among patients with chronic kidney disease in outpatient and inpatient settings (2014) Medicine (Baltimore); Sarnak, M.J., Jaber, B.L., Pulmonary infectious mortality among patients with end-stage renal disease (2001) Chest, 120, pp. 1883-1887; Guan, W.-J., Ni, Z.-Y., Hu, Y., Clinical characteristics of coronavirus disease 2019 in China (2020) N Engl J Med; Liu, Y., Yang, Y., Zhang, C., Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury (2020) Sci China Life Sci, 63, pp. 364-374; Wang, D., Hu, B., Hu, C., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) JAMA; Zhang, J.-J., Dong, X., Cao, Y.-Y., Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China (2020) Allergy","Henry, B.M.; Cardiac Intensive Care Unit, The Heart Institute, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, United States; email: Brandon.henry@cchmc.org",,Springer,3011623,,IURNA,,English,Int. Urol. Nephrol.,Letter,Article in Press,Open Access,Scopus,2-s2.0-85082427357,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Curtis J.R., Kross E.K., Stapleton R.D.",57190804137;24366491500;9735818600;,The Importance of Addressing Advance Care Planning and Decisions about Do-Not-Resuscitate Orders during Novel Coronavirus 2019 (COVID-19),2020,JAMA - Journal of the American Medical Association,,,,,,,,10.1001/jama.2020.4894,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082420940&doi=10.1001%2fjama.2020.4894&partnerID=40&md5=080c61ee6b3c9aa6688e32c774c2cad9,"Division of Pulmonary, Critical Care, and Sleep Medicine, University of Washington, Seattle, United States; Cambia Palliative Care Center of Excellence, University of Washington, 325 Ninth Ave, Seattle, WA 98104, United States; Larner College of Medicine, Division of Pulmonary and Critical Care Medicine, University of Vermont, Burlington, United States","Curtis, J.R., Division of Pulmonary, Critical Care, and Sleep Medicine, University of Washington, Seattle, United States, Cambia Palliative Care Center of Excellence, University of Washington, 325 Ninth Ave, Seattle, WA 98104, United States; Kross, E.K., Division of Pulmonary, Critical Care, and Sleep Medicine, University of Washington, Seattle, United States, Cambia Palliative Care Center of Excellence, University of Washington, 325 Ninth Ave, Seattle, WA 98104, United States; Stapleton, R.D., Larner College of Medicine, Division of Pulmonary and Critical Care Medicine, University of Vermont, Burlington, United States",[No abstract available],,,"Fried, T.R., Bradley, E.H., Towle, V.R., Allore, H., Understanding the treatment preferences of seriously ill patients (2002) N Engl J Med, 346 (14), pp. 1061-1066. , http://dx.doi.org/10.1056/NEJMsa012528, doi: PMID 11932474; Wu, C., Chen, X., Cai, Y., Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China (2020) JAMA Intern Med, , http://jamanetwork.com/article.aspx?doi=10.1001/jamainternmed.2020.0994, doi: PMID 32167524; Arentz, M., Yim, E., Klaff, L., Characteristics and outcomes of 21 critically ill patients with COVID-19 in Washington State (2020) JAMA, , http://jamanetwork.com/article.aspx?doi=10.1001/jama.2020.4326, doi: PMID 32191259; Rubenfeld, G., The coronavirus is a chance to have the end-of-life conversations we need (2020) The Globe and Mail, , https://www.theglobeandmail.com/opinion/article-the-coronavirus-is-a-chance-to-have-the-end-of-life-conversations-we/, March 16, Accessed March 3, 2020; Sudore, R.L., Schillinger, D., Katen, M.T., Engaging diverse English- And Spanish-speaking older adults in advance care planning- And PREPARE randomized clinical trial (2018) JAMA Intern Med, 178 (12), pp. 1616-1625. , http://jamanetwork.com/article.aspx?doi=10.1001/jamainternmed.2018.4657, doi: PMID 30383086; Goodman, E., (2020) The Conversation Project Is Dedicated to Helping People Talk about Their Wishes for End-of-life Care., , http://theconversationproject.org, Institute for Healthcare Improvement. Published. Accessed March 21, 2020; Back, A.L., Arnold, R.M., Edwards, K., Tulsky, J.A., (2020) COVID-ready Communication Skills, , https://www.vitaltalk.org/guides/covid-19-communication-skills/, VITALtalk. Published. Accessed March 21, 2020; Ornstein, K.A., Aldridge, M.D., Garrido, M.M., The use of life-sustaining procedures in the last month of life is associated with more depressive symptoms in surviving spouses (2017) J Pain Symptom Manage, 53 (2), pp. 178-187. , http://dx.doi.org/10.1016/j.jpainsymman.2016.08.023, doi: PMID 27864126 e171; Curtis, J.R., Burt, R.A., Point: The ethics of unilateral ""do not resuscitate"" orders: The role of ""informed assent"" (2007) Chest, 132 (3), pp. 748-751. , http://dx.doi.org/10.1378/chest.07-0745, doi: PMID 17873188; Bosslet, G.T., Kesecioglu, J., White, D.B., How should clinicians respond to requests for potentially inappropriate treatment? (2016) Intensive Care Med, 42 (3), pp. 422-425. , http://dx.doi.org/10.1007/s00134-015-4192-4, doi: PMID 26762106","Curtis, J.R.; Cambia Palliative Care Center of Excellence, University of Washington, 325 Ninth Ave, United States; email: jrc@u.washington.edu",,American Medical Association,987484,,JAMAA,,English,JAMA,Note,Article in Press,Open Access,Scopus,2-s2.0-85082420940,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Kwok K.O., Wong V., Wei V.W.I., Wong S.Y.S., Tang J.W.-T.",35983448100;57215971809;56237605400;21741577200;10341387300;,Novel coronavirus (2019-nCoV) cases in Hong Kong and implications for further spread,2020,Journal of Infection,,,,,,,1,10.1016/j.jinf.2020.02.002,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082420102&doi=10.1016%2fj.jinf.2020.02.002&partnerID=40&md5=768bf90aec50b6cc8c9bce8cbb02cf9c,"The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong; Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Shatin, Hong Kong; Shenzhen Research Institute of The Chinese University of Hong Kong, Shenzhen, China; Clinical Microbiology, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom; Respiratory Sciences, University of Leicester, Leicester, United Kingdom","Kwok, K.O., The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Shatin, Hong Kong, Shenzhen Research Institute of The Chinese University of Hong Kong, Shenzhen, China; Wong, V., The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong; Wei, V.W.I., The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong; Wong, S.Y.S., The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong; Tang, J.W.-T., Clinical Microbiology, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom, Respiratory Sciences, University of Leicester, Leicester, United Kingdom",[No abstract available],,,"Tang, J.W., Tambyah, P.A., Hui, D.S.C., Emergence of a novel coronavirus causing respiratory illness from Wuhan, China (2020) J Infect, , pii: S0163-4453(20)30038-4[Epub ahead of print]; https://www.worldometers.info/coronavirus/, Wuhan coronavirus outbreak.2 February 2020; Government of Hong Kong SAR, (2018), https://www.info.gov.hk/gia/general/201802/07/P2018020700291.htm, Cross-boundary passenger traffic estimation and arrangements for Lunar New Year festive period. 7 Feb; https://www.japantimes.co.jp/news/2020/01/28/national/japan-first-domestic-transmission-coronavirus/, The Japan Times. Japan reports first domestic transmission of coronavirus. 28 January 2020; https://globalnews.ca/news/6472303/german-coronavirus-human-to-human-transmission/, Global News. German man who never visited china catches coronavirus through human-to-human transmission. 28 January 2020; https://edition.cnn.com/2020/01/30/health/coronavirus-illinois-person-to-person-cdc/index.html, CNN Health. First case of person-to-person transmission of Wuhan virus in the US confirmed. 30 January 2020; Chan, J.F., Yuan, S., Kok, K.H., To, K.K., Chu, H., Yang, J., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, , pii: S0140-6736(20)30154-9[Epub ahead of print]; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet., , pii: S0140-6736(20)30183-5[Epub ahead of print]; https://www.aljazeera.com/news/2020/01/hong-kong-cancels-chinese-year-celebrations-200118140832768.html, Al Jazeera. Hong Kong cancels Chinese New Year celebrations. 18 January 2020; https://www.washingtonpost.com/world/coronavirus-china-wuhan-latest/2020/01/23/2dc947a8-3d45-11ea-afe2-090eb37b60b1_story.html, The Washington Post. Chinese cities cancel New Year celebrations, travel ban widens in effort to stop coronavirus outbreak. 24 January 2020; Kwok, K.O., Cowling, B., Wei, V., Riley, S., Read, J.M., Temporal variation of human encounters and the number of locations in which they occur: a longitudinal study of Hong Kong residents (2018) J R Soc Interface, 15 (138). , pii: 20170838; https://www.scmp.com/news/hong-kong/education/article/3048305/hong-kong-universities-suspend-classes-until-march-china, South China Morning Post. Hong Kong schools, kindergartens closed until at least March 2 as coronavirus fears grow, three universities take similar action. 30 January 2020; https://www.scmp.com/news/hong-kong/health-environment/article/3047689/china-coronavirus-hong-kong-has-its-sixth-patient, South China Morning Post. China coronavirus: hong kong will ban anyone who has been to Hubei province from entering city, in response to mounting calls to tighten border checks. 26 January 2020","Kwok, K.O.Room 419, School of Public Health, Prince of Wales Hospital, Hong Kong; email: kkokwok@cuhk.edu.hk",,W.B. Saunders Ltd,1634453,,JINFD,32092391,English,J. Infect.,Letter,Article in Press,Open Access,Scopus,2-s2.0-85082420102,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wang Q., Yu C.",57199483426;57194947290;,Letter to editor: Role of masks/respirator protection against 2019-novel coronavirus (COVID-19),2020,Infection Control and Hospital Epidemiology,,,,,,,,10.1017/ice.2020.83,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082419579&doi=10.1017%2fice.2020.83&partnerID=40&md5=b1f3a4a4896805df4c85bea628b32954,"Fudan University, Shanghai Cancer Center, Fudan University, Shanghai, 200025, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200025, China","Wang, Q., Fudan University, Shanghai Cancer Center, Fudan University, Shanghai, 200025, China, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200025, China; Yu, C., Fudan University, Shanghai Cancer Center, Fudan University, Shanghai, 200025, China, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200025, China",[No abstract available],,,"Novel Coronavirus (COVID-19) Situation Report-13, , https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200202-sitrep-13-ncov-v3.pdf?sfvrsn=195f4010_6, World Health Organization; Munster, V.J., Koopmans, M., Van Doremalen, N., A novel coronavirus emerging in China-key questions for impact assessment[J] (2020) New England Journal of Medicine; Wang, W., Tang, J., Wei, F., Updated understanding of the outbreak of 2019 novel coronavirus (2019-nCoV) in Wuhan, China[J] Journal of Medical Virology; Lu, R., Zhao, X., Li, J., Niu, P., Yang, B., Wu, H., Wang, W., Tan, W., Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding (2020) Lancet, , London, England, published online EpubJan 30; Zhou, P., Huang, Z., Xiao, Y., Huang, X., Fan, X., Protecting Chinese healthcare workers while combating the 2019 novel coronavirus Infection Control & Hospital Epidemiology, pp. 1-4; Wang, X., Pan, Z., Cheng, Z., (2020) Association between 2019-nCoV Transmission and N95 Respirator Use, , medRxiv 2020.2002.2018.20021881; Offeddu, V., Yung, C.F., Low, M.S.F., Effectiveness of masks and respirators against respiratory infections in healthcare workers: A systematic review and meta-analysis[J] (2017) Clinical Infectious Diseases, 65 (11), pp. 1934-1942; Radonovich, L.J., Simberkoff, M.S., Bessesen, M.T., N95 respirators vs medical masks for preventing influenza among health care personnel: A randomized clinical trial[J] (2019) Jama, 322 (9), pp. 824-833; Jefferson, T., Del Mar, C.B., Dooley, L., Physical interventions to interrupt or reduce the spread of respiratory viruses[J] (2011) Cochrane Database of Systematic Reviews, (7); Holshue, M.L., DeBolt, C., Lindquist, S., Lofy, K.H., Wiesman, J., Bruce, H., Spitters, C., Pillai, S.K., First case of 2019 novel coronavirus in the United States (2020) New England Journal of Medicine","Yu, C.; Department of Oncology, Shanghai Medical College, Fudan UniversityChina; email: chaoran_yu@yeah.net",,Cambridge University Press,0899823X,,ICEPE,32192550,English,Infect. Control Hosp. Epidemiol.,Letter,Article in Press,Open Access,Scopus,2-s2.0-85082419579,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Miani A., Burgio E., Piscitelli P., Lauro R., Colao A.",57211192776;26665259500;36944994400;7005732682;56438992800;,The Italian war-like measures to fight coronavirus spreading: Re-open closed hospitals now,2020,EClinicalMedicine,,,100320,,,,,10.1016/j.eclinm.2020.100320,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082418705&doi=10.1016%2fj.eclinm.2020.100320&partnerID=40&md5=2ad0e0ac7f1b223264b1ed6b240b4613,"Italian Society of Environmental Medicine (SIMA), Milan, Italy; UNESCO Chair on Health Education and Sustainable Development, University of Naples Federico II, Naples, Italy; University of Milan, Milan, Italy; University of Rome Tor Vergata, Rome, Italy","Miani, A., Italian Society of Environmental Medicine (SIMA), Milan, Italy, UNESCO Chair on Health Education and Sustainable Development, University of Naples Federico II, Naples, Italy, University of Milan, Milan, Italy; Burgio, E., Italian Society of Environmental Medicine (SIMA), Milan, Italy; Piscitelli, P., Italian Society of Environmental Medicine (SIMA), Milan, Italy, UNESCO Chair on Health Education and Sustainable Development, University of Naples Federico II, Naples, Italy; Lauro, R., Italian Society of Environmental Medicine (SIMA), Milan, Italy, University of Rome Tor Vergata, Rome, Italy; Colao, A., Italian Society of Environmental Medicine (SIMA), Milan, Italy, UNESCO Chair on Health Education and Sustainable Development, University of Naples Federico II, Naples, Italy",[No abstract available],,,"Covid-19: too little, too late? (2020) Lancet, 395 (10226). , P755; Kavanagh, M.M., Authoritarianism, outbreaks, and information politics (2020) Lancet Public Health, 5 (3). , PE135-136; Piscitelli, P., Miani, A., Mazza, A., Triassi, M., De Donno, A., Scala, A., Pulimeno, M., Colao, A., Health-care inequalities in Italy: challenges for the Government (2019) Lancet Public Health, 4 (12), p. e605; Guan, W.J., Ni, Z.Y., Hu, Y., Liang, W.H., Ou, C.Q., He, J.X., Liu, L., Du, B., Clinical characteristics of coronavirus disease 2019 in China (2020) New Engl J Med, 382; Emerging zoonoses: a one health challenge (2020) EClinicalMedicine, 19","Piscitelli, P.; Euro Mediterranean Scientific Biomedical, Institute (ISBEM), Rue Beillard 20, Belgium; email: priscofreedom@hotmail.com",,Lancet Publishing Group,25895370,,,,English,EClinicalMedicine,Note,Article in Press,Open Access,Scopus,2-s2.0-85082418705,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wang K., Kang S., Tian R., Zhang X., Wang Y.",57215937483;57215932916;57215933452;57215938195;56201225700;,Imaging manifestations and diagnostic value of chest CT of coronavirus disease 2019 (COVID-19) in the Xiaogan area,2020,Clinical Radiology,75,5,,341,347,,,10.1016/j.crad.2020.03.004,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082417600&doi=10.1016%2fj.crad.2020.03.004&partnerID=40&md5=8220758b68506f370c292d0fc6c25649,"Department III of Orthopedics, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan, Hubei 432000, China; Department of Medical Imaging, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan, Hubei 432000, China; Department of Clinical Laboratory, The Third People Hospital of Heze, Heze, Shandong 274000, China","Wang, K., Department III of Orthopedics, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan, Hubei 432000, China; Kang, S., Department of Medical Imaging, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan, Hubei 432000, China; Tian, R., Department of Medical Imaging, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan, Hubei 432000, China; Zhang, X., Department III of Orthopedics, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan, Hubei 432000, China, Department of Clinical Laboratory, The Third People Hospital of Heze, Heze, Shandong 274000, China; Wang, Y., Department of Medical Imaging, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan, Hubei 432000, China","AIM: To report the epidemiological, clinical, and radiological characteristics of patients with COVID-19 in Xiaogan, Hubei, China. MATERIALS AND METHODS: The complete clinical and imaging data of 114 confirmed COVID-19 patients treated in Xiaogan Hospital were analysed retrospectively. Data were gathered regarding the presence of chest computed tomography (CT) abnormalities; the distribution, morphology, density, location, and stage of abnormal shadows on chest CT; and observing the correlation between the severity of chest infection and lymphocyte ratio and blood oxygen saturation (SPO2) in patients. RESULTS: Chest CT revealed abnormal lung shadows in 110 patients. Regarding lesion distribution, multi-lobe lesions in both lungs were present in most patients (80 cases; 72.7%). Lesions most frequently involved both the peripheral zone and the central zone (62 cases; 56.4%). Regarding lesion morphology, 56 cases (50.1%) demonstrated patchy shadows that were partially fused into large areas. Thirty cases showed ground-glass opacity (27.3%), 30 cases showed the consolidation change (27.3%), and the remaining 50 cases showed both types of changes (45.4%). The progressing stage was the most common stage (54 cases; 49.1%). CT results showed a negative correlation with SPO2 and lymphocyte numbers (p<0.05), with r-values of −0.446 and −0.780, respectively. CONCLUSION: Spiral CT is a sensitive examination method, which can be applied to make an early diagnosis and for evaluation of progression, with a diagnostic sensitivity and accuracy better than that of nucleic acid detection. © 2020 The Royal College of Radiologists",,,"Lu, H., Stratton, C.W., Tang, Y.W., Outbreak of pneumonia of unknow etiology in Wuhan China: the mystery and the miracle (2020) J Med Virol, , Jan 16; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, pp. 30211-30217. , Jan 30; Xie, X., Zhong, Z., Zhao, W., Chest CT for typical 2019-nCoV pneumonia: relationship to negative RT-PCR testing (2020) Radiology, p. 200343; Duan, Y.N., Qin, J., Pre- and posttreatment chest CT findings: 2019 novel coronavirus (2019-nCoV) pneumonia (2020) Radiology, p. 200323; Lei, J., Li, J., Li, X., CT Imaging of the 2019 novel coronavirus (2019-nCoV) pneumonia (2020) Radiology, p. 200236; Chen, L., Liu, H.G., Liu, W., Analysis of clinical features of 29 patients with 2019 novel coronavirus pneumonia (2020) Zhonghua Jie He He Hu Xi Za Zhi, 43, p. E005. , 0; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet; Pan, Y., Guan, H., Zhou, S., Initial CT findings and temporal changes in patients with the novel coronavirus pneumonia (2019-nCoV): a study of 63 patients in Wuhan, China (2020) Eur Radiol","Kang, S.; Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, 6 Guangchang Road, Xiaonan District, China; email: 864048615@qq.com",,W.B. Saunders Ltd,99260,,CLRAA,32216961,English,Clin. Radiol.,Article,Final,Open Access,Scopus,2-s2.0-85082417600,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wang Q., Qiu Y., Li J.-Y., Zhou Z.-J., Liao C.-H., Ge X.-Y.",57207885215;57214161427;57192312600;57215606676;57215935115;35781787600;,A Unique Protease Cleavage Site Predicted in the Spike Protein of the Novel Pneumonia Coronavirus (2019-nCoV) Potentially Related to Viral Transmissibility,2020,Virologica Sinica,,,,,,,,10.1007/s12250-020-00212-7,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082417004&doi=10.1007%2fs12250-020-00212-7&partnerID=40&md5=4c24778f061bf0f03e0d229329a03d62,"Hunan Provincial Key Laboratory of Medical Virology, Institute of Pathogen Biology and Immunology, College of Biology, Hunan University, Changsha, Hunan 410082, China","Wang, Q., Hunan Provincial Key Laboratory of Medical Virology, Institute of Pathogen Biology and Immunology, College of Biology, Hunan University, Changsha, Hunan 410082, China; Qiu, Y., Hunan Provincial Key Laboratory of Medical Virology, Institute of Pathogen Biology and Immunology, College of Biology, Hunan University, Changsha, Hunan 410082, China; Li, J.-Y., Hunan Provincial Key Laboratory of Medical Virology, Institute of Pathogen Biology and Immunology, College of Biology, Hunan University, Changsha, Hunan 410082, China; Zhou, Z.-J., Hunan Provincial Key Laboratory of Medical Virology, Institute of Pathogen Biology and Immunology, College of Biology, Hunan University, Changsha, Hunan 410082, China; Liao, C.-H., Hunan Provincial Key Laboratory of Medical Virology, Institute of Pathogen Biology and Immunology, College of Biology, Hunan University, Changsha, Hunan 410082, China; Ge, X.-Y., Hunan Provincial Key Laboratory of Medical Virology, Institute of Pathogen Biology and Immunology, College of Biology, Hunan University, Changsha, Hunan 410082, China",[No abstract available],,,"Bertram, S., Glowacka, I., Muller, M.A., Lavender, H., Gnirss, K., Nehlmeier, I., Niemeyer, D., Pohlmann, S., Cleavage and activation of the severe acute respiratory syndrome coronavirus spike protein by human airway trypsin-like protease (2011) J Virol, 85, pp. 13363-13372. , COI: 1:CAS:528:DC%2BC3MXhs1ShsL7M; Bosch, B.J., Bartelink, W., Rottier, P.J., Cathepsin L functionally cleaves the severe acute respiratory syndrome coronavirus class I fusion protein upstream of rather than adjacent to the fusion peptide (2008) J Virol, 82, pp. 8887-8890. , COI: 1:CAS:528:DC%2BD1cXhtVClt73E; Chan, J.F., Yuan, S., Kok, K.H., To, K.K., Chu, H., Yang, J., Xing, F., Yuen, K.Y., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet; Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Zhang, L., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet; Heald-Sargent, T., Gallagher, T., Ready, set, fuse! The coronavirus spike protein and acquisition of fusion competence (2012) Viruses, 4, pp. 557-580. , COI: 1:CAS:528:DC%2BC38XmslOqsbk%3D; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Cao, B., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet; Jiang, S., Shi, Z., Shu, Y., Song, J., Gao, G.F., Tan, W., Guo, D., A distinct name is needed for the new coronavirus (2020) Lancet; Li, F., Evidence for a common evolutionary origin of coronavirus spike protein receptor-binding subunits (2012) J Virol, 86, pp. 2856-2858. , COI: 1:CAS:528:DC%2BC38XivFSqs7k%3D; Lin, Q.C.A., Zhao, S., He, D., Modeling the spread of Middle East respiratory syndrome coronavirus in Saudi Arabia (2018) Stat Methods Med Res, 27, pp. 1968-1978; Lipsitch, M.C.T., Cooper, B., Robins, J.M., Ma, S., James, L., Transmission dynamics and control of severe acute respiratory syndrome (2003) Science, 300, pp. 1966-1970. , COI: 1:CAS:528:DC%2BD3sXks1Klsr8%3D; Wallinga, J.T.P., Different epidemic curves for severe acute respiratory syndrome reveal similar impacts of control measures (2004) Am J Epidemiol, 160, pp. 509-516; Wu, F., Zhao, S., Yu, B., Chen, Y.M., Wang, W., Song, Z.G., Hu, Y., Zhang, Y.Z., A new coronavirus associated with human respiratory disease in China (2020) Nature; Yamada, Y., Liu, D.X., Proteolytic activation of the spike protein at a novel RRRR/S motif is implicated in furin-dependent entry, syncytium formation, and infectivity of coronavirus infectious bronchitis virus in cultured cells (2009) J Virol, 83, pp. 8744-8758. , COI: 1:CAS:528:DC%2BD1MXhtFahurvL; Zhou, P., Yang, X.L., Wang, X.G., Hu, B., Zhang, L., Zhang, W., Si, H.R., Shi, Z.L., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature; Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., Zhao, X., Tan, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med","Ge, X.-Y.; Hunan Provincial Key Laboratory of Medical Virology, Institute of Pathogen Biology and Immunology, College of Biology, Hunan UniversityChina; email: xyge@hnu.edu.cn",,Science Press,16740769,,,32198713,English,Virol. Sin.,Letter,Article in Press,Open Access,Scopus,2-s2.0-85082417004,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Das U.N.,16221852900;,Can Bioactive Lipids Inactivate Coronavirus (COVID-19)?,2020,Archives of Medical Research,,,,,,,,10.1016/j.arcmed.2020.03.004,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082416752&doi=10.1016%2fj.arcmed.2020.03.004&partnerID=40&md5=b7bca372a8fc5b7f135b39d8635e5b80,"UND Life Sciences, Battle Ground, WA, United States","Das, U.N., UND Life Sciences, Battle Ground, WA, United States","SARS-CoV-2, SARS and MERS are all enveloped viruses that can cause acute respiratory syndrome. Arachidonic acid (AA) and other unsaturated fatty acids (especially eicosapentaenoic acd, EPA and docosahexaenoic acid DHA) are known to inactivate enveloped viruses and inhibit proliferation of various microbial organisms. The pro-inflammatory metabolites of AA and EPA such as prostaglandins, leukotrienes and thromboxanes induce inflammation whereas lipoxins, resolvins, protectins and maresins derived from AA, EPA and DHA not only suppress inflammation but also enhance would healing and augment phagocytosis of macrophages and other immunocytes and decrease microbial load. In view of these actions, it is suggested that AA and other unsaturated fatty acids and their metabolites may serve as endogenous anti-viral compounds and their deficiency may render humans susceptible to SARS-CoV-2, SARS and MERS and other similar viruses’ infections. Hence, oral or intravenous administration of AA and other unsaturated fatty acids may aid in enhancing resistance and recovery from SARS-CoV-2, SARS and MERS infections. © 2020 IMSS",Arachidonic acid; Inflammation; Lipoxin A4; MERS; Polyunsaturated fatty acids; Prostaglandins; Protectins and maresins; Resolvins; SARS; SARS-CoV-2,,"Wu, Z., McGoogan, J.M., Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China (2020) JAMA, , [Epub ahead of print]; Zhou, P., Yang, X.-L., Wang, X.-G., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature, 579, pp. 270-273; Yan, R., Zhang, Y., Li, Y., Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2 (2020) Science, , [Epub ahead of print]; Wrapp, D., Wang, N., Corbett, K.S., Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation (2020) Science, , [Epub ahead of print]; Speert, D.P., Wannamaker, L.W., Gray, E.D., Bactericidal effect of oleic acid on group A streptococci: mechanism of action (1979) Infect Immun, 26, pp. 1202-1210; Lokesh, B.R., Wrann, M., Incorporation of palmitic acid or oleic acid into macrophage membrane lipids exerts differential effects on the function of normal mouse peritoneal macrophages (1984) Biochim Biophys Acta, 792, pp. 141-148; Juers, J.A., Rogers, R.M., McCurdy, J.B., Enhancement of bactericidal capacity of alveolar macrophages by human alveolar lining material (1976) J Clin Invest, 58, pp. 271-275; Nieman, C., Influence of trace amounts of fatty acids on the growth of microorganisms (1954) Bacteriol Rev, 18, pp. 147-162; Kabara, J.J., Swieczkowski, D.M., Conley, A.J., Fatty acids and derivatives as antimicrobial agents (1972) Antimicrob Agents Chemother, 2, pp. 23-28; Larsson, K., Noren, B., Odham, G., Antimicrobial effect of simple lipids with different branches at the methyl end group (1975) Antimicrob Agents Chemother, 8, pp. 742-750; Heczko, P.B., Lutticken, R., Hryniewicz, W., Susceptibility of Staphylococcus aureus and Group A, B, C, and G streptococci to free fatty acids (1979) J Clin Microbiol, 9, pp. 333-335; Wyss, O., Ludwig, B.J., Joiner, R.R., The fungistatic and fungicidal action of fatty acids and related compounds (1945) Arch Biochem, 7, pp. 415-424; Stock, C.C., Francis, T., Jr., The inactivation of the virus of epidemic influenza by soaps (1940) J Exp Med, 71, pp. 661-681; Sands, J., Auperin, D., Snipes, W., Extreme sensitivity of enveloped viruses, including herpes simplex, to long chain unsaturated monoglycerides and alcohols (1979) Antimicrob Agents Chemother, 15, pp. 67-73; Kohn, A., Gitelman, J., Inbar, M., Unsaturated free fatty acids inactivate animal enveloped viruses (1980) Arch Virol, 66, pp. 301-306; Horowitz, B., Piët, M.P., Prince, A.M., Inactivation of lipid-enveloped viruses in labile blood derivatives by unsaturated fatty acids (1988) Vox Sang, 54, pp. 14-20; Das, U.N., Anti-biotic-like action of essential fatty acids (1985) Can Med Assoc J, 132, p. 1350; Das, U.N., Do unsaturated fatty acids function as endogenous anti-bacterial and anti-viral molecules? (2006) Am J Clin Nutr, 83, pp. 390-391; Das, U.N., Can essential fatty acid deficiency predispose to AIDS? (1985) Can Med Assoc J, 132, pp. 900-902; Das, U.N., Essential fatty acids and acquired immunodeficiency syndrome (2005) Med Sci Monit, 11, pp. RA206-RA211; Das, U.N., Arachidonic acid and other unsaturated fatty acids and some of their metabolites function as endogenous antimicrobial molecules: A review (2018) J Adv Res, 11, pp. 57-66; Sheu, C.W., Konings, W.N., Freese, E., Effects of acetate and other short chain fatty acids on sugar and amino acid uptake of Bacillus subtilis (1972) J Bacteriol, 111, pp. 525-530; Ingram, L.O., Eaton, L.C., Erdos, G.W., Tedder, T.F., Vreeland, N.L., Unsaturated fatty acid requirement in Escherichia coli. Mechanism of palmitate-induced inhibition of growth by strain WNl (1982) J Membr Biol, 1982, pp. 31-40; Fay, J.P., Farias, R.N., Inhibitory action of a nonmetabolizable fatty acid on the growth of Escherichia coli. Role of metabolism and outer membrane integrity (1977) J Bacteriol, 1977, pp. 790-795; Norris, P.C., Arnardottir, H., Sanger, J.M., Resolvin D3 multi-level proresolving actions are host protective during infection (2016) Prostaglandins Leukot Essent Fatty Acids, 22; Ramon, S., Dalli, J., Sanger, J.M., The protectin PCTR1 is produced by human M2 macrophages and enhances resolution of infectious inflammation (2016) Am J Pathol, 186, pp. 962-973; Dalli, J., Winkler, J.W., Colas, R.A., Resolvin D3 and aspirin-triggered resolvin D3 are potent immunoresolvents (2013) Chem Biol, 20, pp. 188-201; Wu, B., Walker, J., Spur, B., Effects of Lipoxin A4 on antimicrobial actions of neutrophils in sepsis (2015) Prostaglandins Leukot Essent Fatty Acids, 94, pp. 55-64; Walker, J., Dichter, E., Lacorte, G., Lipoxin A4 increases survival by decreasing systemic inflammation and bacterial load in sepsis (2011) Shock, 36, pp. 410-416; Wu, B., Capilato, J., Pham, M.P., Lipoxin A4 augments host defense in sepsis and reduces Pseudomonas aeruginosa virulence through quorum sensing inhibition (2016) FASEB J, 30, pp. 2400-2410; Poorani, R., Bhatt, A.N., Dwarakanath, B.S., COX-2, aspirin and metabolism of arachidonic, eicosapentaenoic and docosahexaenoic acids and their physiological and clinical significance (2016) Eur J Pharmacol, 785, pp. 116-132","Das, U.N.; UND Life Sciences, 2221, NW 5th St, United States; email: Undurti@hotmail.com",,Elsevier Inc.,1884409,,AEDEE,,English,Arch. Med. Res.,Article,Article in Press,,Scopus,2-s2.0-85082416752,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Carbone M., Green J.B., Bucci E.M., Lednicky J.A.",7101700660;57215934935;57215932377;6701315850;,"Coronaviruses: Facts, Myths, and Hypotheses",2020,Journal of Thoracic Oncology,,,,,,,,10.1016/j.jtho.2020.02.024,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082416162&doi=10.1016%2fj.jtho.2020.02.024&partnerID=40&md5=8fae02628bc94ed192787f8659b6ca6d,"Thoracic Oncology, University of Hawaii Cancer Center and Department of Pathology, JABSOM Medical School Hawaii, Honolulu, HI, United States; Lieutenant Governor, State of Hawaii, HI, United States; Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, PA, United States; Department of Environmental and Global Health, College of Public Health, University of Florida, Gainesville, FL, United States","Carbone, M., Thoracic Oncology, University of Hawaii Cancer Center and Department of Pathology, JABSOM Medical School Hawaii, Honolulu, HI, United States; Green, J.B., Lieutenant Governor, State of Hawaii, HI, United States; Bucci, E.M., Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, PA, United States; Lednicky, J.A., Department of Environmental and Global Health, College of Public Health, University of Florida, Gainesville, FL, United States",[No abstract available],,,"Tian, S., Hu, W., Niu, L., Liu, H., Xu, H., Xiao, S.Y., (2020), Pulmonary pathology of early phase 2019 novel coronavirus (COVID-19) pneumonia in two patients with lung cancer [e-pub ahead of print]. J Thorac Oncol. Accessed March 13; McCullough, M., Coronavirus will spread in the U.S., CDC warns, and there might not be enough testing capacity to detect it. The Philadelphia Inquirer (2020), https://www.inquirer.com/health/coronavirus-pandemic-cdc-flawed-test-pcr-undetected-cases-20200225.html, Accessed March 13, 2020; Ai, T., Yang, Z., Hou, H., (2020), Correlation of chest CT and RT-PCR testing in coronavirus disease 2019 (COVID-19) in China: a report of 1014 cases [e-pub ahead of print]. Radiology. Accessed March 13; Yanfeng, P., Nucleic acid testing is inaccurate (2020) Caixin; Grady, D., Coronavirus test kits sent to states are flawed, C.D.C. says (2020) The New York Times, , https://www.nytimes.com/2020/02/12/health/coronavirus-test-kits-cdc.html, Accessed March 13, 2020; Corman, V.M., Landt, O., Kaiser, M., Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR (2020) Euro Surveill, 25, p. 2000045; Zhang, W., Du, R.H., Li, B., Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes (2020) Emerg Microbes Infect, 9, pp. 386-389; Liang, W., Guan, W., Chen, R., (2020), Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China [e-pub ahead of print]. Lancet Oncol. Accessed March 13; Cohen, J., Wuhan seafood market may not be source of novel virus spreading globally (2020) Science; Xu, Z., Shi, L., Wang, Y., (2020), https://doi.org/10.1016/S2213-2600(20)30076-X, Pathological findings of COVID-19 associated with acute respiratory distress syndrome [e-pub ahead of print]. Lancet Respir Med. Accessed March 13; Bai, Y., Yao, L., Wei, T., (2020), Presumed asymptomatic carrier transmission of COVID-19 [e-pub ahead of print]. JAMA. Accessed March 13","Carbone, M.; University of Hawaii Cancer Center, 701 Ilalo Street, 4R Room 437, United States; email: mcarbone@cc.hawaii.edu",,Elsevier Inc,15560864,,,32151778,English,J. Thorac. Oncol.,Editorial,Article in Press,Open Access,Scopus,2-s2.0-85082416162,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Chirumbolo S.,6603231780;,Might the many positive COVID19 subjects in Italy have been caused by resident bat-derived zoonotic β-coronaviruses instead of the Wuhan (China) outbreak?,2020,Journal of Medical Virology,,,,,,,,10.1002/jmv.25777,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082410050&doi=10.1002%2fjmv.25777&partnerID=40&md5=c5f6ba5897cac52cadfaa91d714b8adc,"Department of Neurosciences Biomedicine and Movement Sciences, University of Verona, Verona, Italy","Chirumbolo, S., Department of Neurosciences Biomedicine and Movement Sciences, University of Verona, Verona, Italy",[No abstract available],,,"Lai, A., Bergna, A., Acciarri, C., Galli, M., Zehender, G., Early phylogenetic estimate of the effective reproduction number of SARS-CoV-2 J Med Virol, , https://doi.org/10.1002/jmv.25723, [published online ahead of print February 25, 2020]; Kozak, M., Bocianowski, J., Liersch, A., Genetic divergence is not the same as phenotypic divergence (2011) Mol Breed, 28 (2), pp. 277-280; Pybus, O.G., Rambaut, A., Evolutionary analysis of the dynamics of viral infectious disease (2009) Nat Rev Genet, 10 (8), pp. 540-550; De Diego, M.L., Nieto-Torres, J.L., Jimenez-Guardeño, J.M., Coronavirus virulence genes with main focus on SARS-CoV envelope gene (2014) Virus Res, 194, pp. 124-137; Lu, R., Zhao, X., Li, J., Genomic characterization and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet, 395 (10224), pp. 565-574; Menachery, V.D., Graham, R.L., Baric, R.S., Jumping species-a mechanism for coronavirus persistence and survival (2017) Curr Opin Virol, 23, pp. 1-7; Huang, Y., The SARS epidemics and its aftermath in China: a political perspective. Learning from SARS: Preparing for the next disease outbreak, workshop summary (2004) Institute of Medicine (US) Forum on Microbial Threats, , Knobler S, Mahmoud A, Lemon S, eds., Washington (DC), National Academies Press (US); Liu, Z., Xiao, X., Wei, X., Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS-CoV-2 J Med Virol, , https://doi.org/10.1002/jmv.25726, [published online ahead of print February 6, 2020]; Li, X., Zai, J., Zhao, Q., Evolutionary history, potential intermediate animal host, and cross-species analyses of SARS-CoV-2 J Med Virol, , https://doi.org/10.1002/jmv.25731, [published online ahead of print February 27, 2020]; Baldassar, L., Johanson, G., McAuliffe, N., Bressan, M., Chinese Migration to Europe: Prato, Italy and Beyond, 2015. , New York, NY, Palgrave McMillan; Rizzo, F., Edenborough, K.M., Toffoli, R., Coronavirus and paramyxovirus in bats from Northwest Italy (2017) BMC Vet Res, 13 (1), p. 396; Balboni, A., Palladini, A., Bogliani, G., Battilani, M., Detection of a virus related to betacoronaviruses in Italian greater horseshoe bats (2011) Epidemiol Infect, 139 (2), pp. 216-219; Lelli, D., Papetti, A., Sabelli, C., Rosti, E., Moreno, A., Boniotti, M.B., Detection of coronaviruses in bats of various species in Italy (2013) Viruses, 5 (11), pp. 2679-2689; Moreno, A., Lelli, D., de Sabato, L., Detection and full genome characterization of two beta CoV viruses related to Middle East respiratory syndrome from bats in Italy (2017) Virol J, 14 (1), p. 239. , https://doi.org/10.1186/s12985-017-0907-1; Zhang, C.Y., Wei, J.F., He, S.H., Adaptive evolution of the spike gene of SARS coronavirus: changes in positively selected sites in different epidemic groups (2006) BMC Microbiol, 4 (6), p. 88; Albarello, F., Pianura, E., Di Stefano, F., 2019-novel Coronavirus severe adult respiratory distress syndrome in two cases in Italy: an uncommon radiological presentation (2020) Int J Infect Dis, 93, pp. 192-197; Christian, M.D., Loutfy, M., McDonald, L.C., Possible SARS coronavirus transmission during cardiopulmonary resuscitation (2004) Emerg Infect Dis, 10 (2), pp. 287-293","Chirumbolo, S.; Department of Neurosciences Biomedicine and Movement Sciences, University of VeronaItaly; email: salvatore.chirumbolo@univr.it",,John Wiley and Sons Inc.,1466615,,JMVID,,English,J. Med. Virol.,Letter,Article in Press,,Scopus,2-s2.0-85082410050,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Jin X., Lian J.-S., Hu J.-H., Gao J., Zheng L., Zhang Y.-M., Hao S.-R., Jia H.-Y., Cai H., Zhang X.-L., Yu G.-D., Xu K.-J., Wang X.-Y., Gu J.-Q., Zhang S.-Y., Ye C.-Y., Jin C.-L., Lu Y.-F., Yu X., Yu X.-P., Huang J.-R., Xu K.-L., Ni Q., Yu C.-B., Zhu B., Li Y.-T., Liu J., Zhao H., Zhang X., Yu L., Guo Y.-Z., Su J.-W., Tao J.-J., Lang G.-J., Wu X.-X., Wu W.-R., Qv T.-T., Xiang D.-R., Yi P., Shi D., Chen Y., Ren Y., Qiu Y.-Q., Li L.-J., Sheng J., Yang Y.",57215935928;57215934838;57215934087;57202727503;57209991505;57215933247;57215934694;57215937796;56581016800;57209263903;57212830882;8513212000;57215937892;57209257471;57215935351;57215932698;57215932410;57215937311;57215827169;57194687454;57215933079;57215935823;57215864818;57215938112;57215932290;57215938222;57207461925;57215833324;57213542304;57215864429;57215931459;57215937670;57215932400;57215936017;57215071906;57215935926;57215935147;57215934373;57215937263;57215936024;57215934602;57215934563;57215071135;57196183416;7202784409;8636592800;,"Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms",2020,Gut,,,320926,,,,,10.1136/gutjnl-2020-320926,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082407950&doi=10.1136%2fgutjnl-2020-320926&partnerID=40&md5=5fd83762d4268adf7711c928665123c3,"Department of Gastroenterology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China; Department of Neurosurgery, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China","Jin, X., Department of Gastroenterology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China; Lian, J.-S., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China; Hu, J.-H., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China; Gao, J., Department of Gastroenterology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China; Zheng, L., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China; Zhang, Y.-M., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China; Hao, S.-R., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China; Jia, H.-Y., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China; Cai, H., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China; Zhang, X.-L., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China; Yu, G.-D., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China; Xu, K.-J., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China; Wang, X.-Y., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China; Gu, J.-Q., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China; Zhang, S.-Y., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China; Ye, C.-Y., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China; Jin, C.-L., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China; Lu, Y.-F., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China; Yu, X., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China; Yu, X.-P., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China; Huang, J.-R., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China; Xu, K.-L., Department of Neurosurgery, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China; Ni, Q., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China; Yu, C.-B., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China; Zhu, B., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China; Li, Y.-T., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China; Liu, J., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China; Zhao, H., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China; Zhang, X., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China; Yu, L., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China; Guo, Y.-Z., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China; Su, J.-W., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China; Tao, J.-J., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China; Lang, G.-J., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China; Wu, X.-X., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China; Wu, W.-R., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China; Qv, T.-T., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China; Xiang, D.-R., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China; Yi, P., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China; Shi, D., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China; Chen, Y., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China; Ren, Y., Department of Gastroenterology, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China; Qiu, Y.-Q., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China; Li, L.-J., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China; Sheng, J., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China; Yang, Y., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of Medicine, Hangzhou, Zhejiang, 310003, China","Objective: The SARS-CoV-2-infected disease (COVID-19) outbreak is a major threat to human beings. Previous studies mainly focused on Wuhan and typical symptoms. We analysed 74 confirmed COVID-19 cases with GI symptoms in the Zhejiang province to determine epidemiological, clinical and virological characteristics. Design: COVID-19 hospital patients were admitted in the Zhejiang province from 17 January 2020 to 8 February 2020. Epidemiological, demographic, clinical, laboratory, management and outcome data of patients with GI symptoms were analysed using multivariate analysis for risk of severe/critical type. Bioinformatics were used to analyse features of SARS-CoV-2 from Zhejiang province. Results: Among enrolled 651 patients, 74 (11.4%) presented with at least one GI symptom (nausea, vomiting or diarrhoea), average age of 46.14 years, 4-day incubation period and 10.8% had pre-existing liver disease. Of patients with COVID-19 with GI symptoms, 17 (22.97%) and 23 (31.08%) had severe/critical types and family clustering, respectively, significantly higher than those without GI symptoms, 47 (8.14%) and 118 (20.45%). Of patients with COVID-19 with GI symptoms, 29 (39.19%), 23 (31.08%), 8 (10.81%) and 16 (21.62%) had significantly higher rates of fever >38.5°C, fatigue, shortness of breath and headache, respectively. Low-dose glucocorticoids and antibiotics were administered to 14.86% and 41.89% of patients, respectively. Sputum production and increased lactate dehydrogenase/glucose levels were risk factors for severe/critical type. Bioinformatics showed sequence mutation of SARS-CoV-2 with m6A methylation and changed binding capacity with ACE2. Conclusion: We report COVID-19 cases with GI symptoms with novel features outside Wuhan. 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Pan, Y., Zhang, D., Yang, P., Viral load of SARS-CoV-2 in clinical samples (2020) Lancet Infect Dis, , http://dx.doi.org/10.1016/S1473-3099(20)30113-4, [Epub ahead of print: 24 Feb 2020]. http://www.ncbi.nlm.nih.gov/pubmed/32105638","Yang, Y.; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, Zhejiang University, First Affiliated Hospital, College of MedicineChina; email: yangyida65@163.com",,BMJ Publishing Group,175749,,GUTTA,,English,Gut,Article,Article in Press,Open Access,Scopus,2-s2.0-85082407950,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Opriessnig T., Huang Y.-W.",6602341858;8291778500;,Coronavirus disease 2019 (COVID-19) outbreak: Could pigs be vectors for human infections?,2020,Xenotransplantation,,,,,,,,10.1111/xen.12591,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082406370&doi=10.1111%2fxen.12591&partnerID=40&md5=285bf419a413b9aa6909d0023561d4c9,"The Roslin Institute and The Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, United Kingdom; Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, United States; Institute of Preventive Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou, China","Opriessnig, T., The Roslin Institute and The Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, United Kingdom, Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, United States; Huang, Y.-W., Institute of Preventive Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou, China",[No abstract available],,,"Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506; De Groot, R.J., Baker, S.C., Baric, R., Family Coronaviridae, p 806–828De (2012) Virus Taxonomy Ninth Report of the International Committee on Taxonomy of Viruses, , King AMQ, Adams MJ, Carstens EB, Lefkowitz EJ, eds., Amsterdam, Elsevier Academic Press; 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Sikkema, R.S., Mohamedani, A.A., MERS-CoV in camels but not camel handlers, Sudan, 2015 and 2017 (2019) Emerg Infect Dis, 25, pp. 2333-2335; Vergara-Alert, J., van den Brand, J.M., Widagdo, W., Livestock susceptibility to infection with middle east respiratory syndrome coronavirus (2017) Emerg Infect Dis, 23, pp. 232-240; Zhou, P., Yang, X.L., Wang, X.G., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature, 579 (7798), pp. 270-273; Chang, L., Yan, Y., Wang, L., Coronavirus disease 2019: coronaviruses and blood safety (2020) Transfus Med Rev, , https://doi.org/10.1016/j.tmrv.2020.02.003, [Epub ehead of print]; Holshue, M.L., DeBolt, C., Lindquist, S., First case of 2019 novel coronavirus in the United States (2020) N Engl J Med, 382 (10), pp. 929-936","Opriessnig, T.; The Roslin Institute and The Royal (Dick) School of Veterinary Studies, University of EdinburghUnited Kingdom; email: Tanja.Opriessnig@roslin.ed.ac.uk",,Blackwell Publishing Inc.,0908665X,,XENOF,,English,Xenotransplantation,Note,Article in Press,,Scopus,2-s2.0-85082406370,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Dahl E.,57215802693;,Coronavirus (Covid-19) outbreak on the cruise ship Diamond Princess,2020,International maritime health,71,1,,5,8,,,10.5603/MH.2020.0003,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082380657&doi=10.5603%2fMH.2020.0003&partnerID=40&md5=279de99d9dbf4ef37dceff3c41882423,"Department of Occupational Medicine, Norwegian Centre for Maritime and Diving Medicine, Haukeland University Hospital, Bergen, Norway","Dahl, E., Department of Occupational Medicine, Norwegian Centre for Maritime and Diving Medicine, Haukeland University Hospital, Bergen, Norway",Not applicable for Editorials.,coronavirus; covid-19; crew; cruise ship medicine; outbreak; passengers,,,,,NLM (Medline),20813252,,,32212140,English,Int Marit Health,Article,Final,Open Access,Scopus,2-s2.0-85082380657,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Sikorska K.,6602482534;,Coronavirus Disease 2019 as a challenge for maritime medicine,2020,International maritime health,71,1,,4,,,,10.5603/IMH.2020.0002,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082380373&doi=10.5603%2fIMH.2020.0002&partnerID=40&md5=a9ca016845a4a93e8788a272b9e744c9,"Department of Tropical and Parasitic Diseases, Institute of Maritime and Tropical Medicine, Faculty of Health Sciences with Institute of Maritime and Tropical Medicine, Medical University of Gdansk, Gdynia, Poland","Sikorska, K., Department of Tropical and Parasitic Diseases, Institute of Maritime and Tropical Medicine, Faculty of Health Sciences with Institute of Maritime and Tropical Medicine, Medical University of Gdansk, Gdynia, Poland",[No abstract available],,,,,,NLM (Medline),20813252,,,32212138,English,Int Marit Health,Article,Final,Open Access,Scopus,2-s2.0-85082380373,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Hsu L.Y., Chia P.Y., Lim J.F.",57212628685;57215907622;57215908259;,The Novel Coronavirus (SARS-CoV-2) Epidemic,2020,"Annals of the Academy of Medicine, Singapore",49,1,,1,3,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082342162&partnerID=40&md5=5b053e3439cd67007c375ba41ab6d6d5,"Saw Swee Hock School of Public Health, National University of Singapore, Singapore","Hsu, L.Y., Saw Swee Hock School of Public Health, National University of Singapore, Singapore; Chia, P.Y.; Lim, J.F.",[No abstract available],,"COVID-19; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; Coronavirus infection; genetics; health care delivery; human; infection control; pathogenicity; public health; Singapore; virus pneumonia; Betacoronavirus; Coronavirus Infections; Delivery of Health Care; Humans; Infection Control; Pneumonia, Viral; Public Health; Singapore",,,,NLM (Medline),3044602,,,32200398,English,Ann. Acad. Med. Singap.,Editorial,Final,,Scopus,2-s2.0-85082342162,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Ciulla M.M.,7003820395;,Coronavirus uses as binding site in humans angiotensin-converting enzyme 2 functional receptor that is involved in arterial blood pressure control and fibrotic response to damage and is a drug target in cardiovascular disease. Is this just a phylogenetic coincidence?,2020,Journal of Medical Virology,,,,,,,,10.1002/jmv.25774,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082341905&doi=10.1002%2fjmv.25774&partnerID=40&md5=046757fce351419abbd07f55f47f7af6,"Laboratory of Clinical Informatics and Cardiovascular Imaging, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy","Ciulla, M.M., Laboratory of Clinical Informatics and Cardiovascular Imaging, Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy",[No abstract available],,,"Liu, Z., Xiao, X., Wei, X., Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS-CoV-2 (2020) J Med Virol, , https://doi.org/10.1002/jmv.25726, [published online ahead of print February 26, 2020]; Lu, R., Zhao, X., Li, J., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet, 395 (10224), pp. 565-574; Li, W., Moore, M.J., Vasilieva, N., Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus (2003) Nature, 426, pp. 450-454; Wang, H., Yang, P., Liu, K., SARS coronavirus entry into host cells through a novel clathrin- and caveolae-independent endocytic pathway (2008) Cell Res, 18, pp. 290-301; Ciulla, M.M., Paliotti, R., Esposito, A., Different effects of antihypertensive therapies based on losartan or atenolol on ultrasound and biochemical markers of myocardial fibrosis: results of a randomized trial (2004) Circulation, 110 (5), pp. 552-557. , https://doi.org/10.1161/01.CIR.0000137118.47943.5C; Ferreira, S.H., Angiotensin converting enzyme: history and relevance (2000) Semin Perinatol, 24 (1), pp. 7-10. , https://doi.org/10.1016/s0146-0005(00)80046-4; Brown, N.J., Vaughan, D.E., Angiotensin-converting enzyme inhibitors (1998) Circulation, 97 (14), pp. 1411-1420. , https://doi.org/10.1161/01.cir.97.14.1411; Donoghue, M., Hsieh, F., Baronas, E., A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9 (2000) Circ Res, 87, pp. E1-E9; Gao, Q.Y., Chen, Y.X., Fang, J.Y., 2019 Novel coronavirus infection and gastrointestinal tract (2020) J Dig Dis, , https://doi.org/10.1111/1751-2980.12851, [published online ahead of print February 25, 2020]","Ciulla, M.M.; Laboratory of Clinical Informatics and Cardiovascular Imaging, Department of Clinical Sciences and Community Health, University of MilanItaly; email: michele.ciulla@unimi.it",,John Wiley and Sons Inc.,1466615,,JMVID,,English,J. Med. Virol.,Letter,Article in Press,,Scopus,2-s2.0-85082341905,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Merchant R.M., Lurie N.",14028632100;7006649471;,Social media and emergency preparedness in response to novel coronavirus,2020,JAMA - Journal of the American Medical Association,,,,,,,,10.1001/jama.2020.4469,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082336538&doi=10.1001%2fjama.2020.4469&partnerID=40&md5=763802535e5452d50dd4a2173b71edde,"Penn Medicine Center for Digital Health, University of Pennsylvania Perelman School of Medicine, 3400 Civic Center Blvd, Philadelphia, PA 19104, United States; Department of Emergency Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States; Coalition for Epidemic Preparedness Innovation, Washington, DC, United States; Massachusetts General Hospital, Boston, United States","Merchant, R.M., Penn Medicine Center for Digital Health, University of Pennsylvania Perelman School of Medicine, 3400 Civic Center Blvd, Philadelphia, PA 19104, United States, Department of Emergency Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, United States; Lurie, N., Coalition for Epidemic Preparedness Innovation, Washington, DC, United States, Massachusetts General Hospital, Boston, United States",[No abstract available],,,"Paules, C.I., Marston, H.D., Fauci, A.S., Coronavirus infections - More than just the common cold (2020) JAMA, , http://jamanetwork.com/article.aspx?doi=10.1001/jama.2020.0757, Published online January 23, doi: PMID 31971553; Clement, J., Number of global social media users 2010-2021 (2020) Statista Website, , https://www.statista.com/statistics/278414/number-of-worldwide-social-network-users/, Published August 14, 2019. Accessed March 16; Jin, K.-X., Keeping people safe and informed about the coronavirus (2020) Facebook Newsroom Website. Updated March 18, 2020, , https://about.fb.com/news/2020/03/coronavirus, Accessed March 19; Josephson, A., Lambe, E., Brand communications in time of crisis (2020) Twitter Blog Website, , https://blog.twitter.com/en_us/topics/company/2020/Brand-communications-in-time-of-crisis.html, Published March 11, 2020. Accessed March 16; World Health Organization (2019) Novel Coronavirus (-nCoV): Situation report-13, , https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200202-sitrep-13-ncov-v3.pdf, Published February 2, 2020. Accessed March 16; Merchant, R.M., Evaluating the potential role of social media in preventive health care (2020) JAMA, 323 (5), pp. 411-412. , http://jamanetwork.com/article.aspx?doi=10.1001/jama.2019.21084, doi: PMID 31922532; Connecting people with resources (2020) Facebook Preventive Health Website, , https://preventivehealth.facebook.com/, Accessed March 16; How do i use crisis response on facebook to give help (2020) Facebook Help Center Website, , https://www.facebook.com/help/1786622978265847?helpref=related&source-cms-id=1761941604022087, Accessed March 16; Merchant, R.M., Asch, D.A., Crutchley, P., Evaluating the predictability of medical conditions from social media posts (2019) PLoS One, 14 (6). , http://dx.doi.org/10.1371/journal.pone.0215476, _artnr e0215476. doi: PMID 31206534","Merchant, R.M.; Penn Medicine Center for Digital Health, University of Pennsylvania Perelman School of Medicine, 3400 Civic Center Blvd, United States; email: raina.merchant@pennmedicine.upenn.edu",,American Medical Association,987484,,JAMAA,32202611,English,JAMA,Note,Article in Press,Open Access,Scopus,2-s2.0-85082336538,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Ronco C., Reis T., De Rosa S.",57202559302;57215903681;56601175600;,Coronavirus Epidemic and Extracorporeal Therapies in Intensive Care: Si vis pacem para bellum,2020,Blood Purification,,,,,,,,10.1159/000507039,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082331105&doi=10.1159%2f000507039&partnerID=40&md5=85430b3510f1c7ff032f5628b46ec1e4,"Department of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, Viale Rodolfi, 37, Vicenza, IT-36100, Italy; International Renal Research Institute Vicenza, Vicenza, Italy; Department of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, Vicenza, Italy; Clinica de Doenças Renais de Brasilia, Brasilia, Brazil; Intensive Care Unit, San Bortolo Hospital, Vicenza, Italy","Ronco, C., Department of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, Viale Rodolfi, 37, Vicenza, IT-36100, Italy, International Renal Research Institute Vicenza, Vicenza, Italy, Department of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, Vicenza, Italy; Reis, T., International Renal Research Institute Vicenza, Vicenza, Italy, Clinica de Doenças Renais de Brasilia, Brasilia, Brazil; De Rosa, S., International Renal Research Institute Vicenza, Vicenza, Italy, Intensive Care Unit, San Bortolo Hospital, Vicenza, Italy",[No abstract available],,,"Global Surveillance for Human Infection with Coronavirus Disease (covid-19), , https://www.who.int/publications-detail/global-surveillance-for-human-infection-with-novel-coronavirus-(2019-ncov), World Health Organization Interim guidance 27 February 2020 [cited 2020 Mar 4]; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Al, E., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395 (10223), pp. 497-506. , Feb; Wu, Z., McGoogan, J.M., Characteristics of and Important Lessons from the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72314 Cases from the Chinese Center for Disease Control and Prevention (2020) JAMA, , Epub ahead of print; Gates, B., Responding to Covid-19-A Once-in-A-Century Pandemic? (2020) N Engl J Med, , Epub ahead of print; Hoehl, S., Berger, A., Kortenbusch, M., Cinatl, J., Bojkova, D., Rabenau, H., Al, E., Evidence of SARS-CoV-2 Infection in Returning Travelers from Wuhan, China (2020) N Engl J Med, , Epub ahead of print; Ronco, C., Navalesi, P., Vincent, J.L., Coronavirus epidemic: Preparing for extracorporeal organ support in intensive care (2020) Lancet Respir Med, 8 (3), pp. 240-241. , Mar; Morens, D.M., Daszak, P., Taubenberger, J.K., Escaping Pandora's Box-Another Novel Coronavirus (2020) N Engl J Med, , Epub ahead of print; Yang, X., Yu, Y., Xu, J., Shu, H., Xia, J., Liu, H., Al, E., Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: A single-centered, retrospective, observational study (2020) Lancet Respir Med, , Epub ahead of print; Gao, Q.Y., Chen, Y.X., Fang, J.Y., Novel coronavirus infection and gastrointestinal tract (2019) J Dig Dis, , Epub ahead of print; Young, B.E., Ong, S.W., Kalimuddin, S., Low, J.G., Tan, S.Y., Loh, J., Al, E., Epidemiologic Features and Clinical Course of Patients Infected with SARS-CoV-2 in Singapore (2020) JAMA, , Singapore 2019 Novel Coronavirus Outbreak Research Team, Epub ahead of print; Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Al, E., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study (2020) Lancet, 395 (10223), pp. 507-513. , Feb; Ruan, Q., Yang, K., Wang, W., Jiang, L., Song, J., Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China (2020) Intensive Care Med, , Epub ahead of print; Alhogbani, T., Acute myocarditis associated with novel Middle east respiratory syndrome coronavirus (2016) Ann Saudi Med, 36 (1), pp. 78-80. , Jan-Feb; Kotecha, A., Vallabhajosyula, S., Coville, H.H., Kashani, K., Cardiorenal syndrome in sepsis: A narrative review (2018) J Crit Care, 43, pp. 122-127. , Feb; Beutel, G., Wiesner, O., Eder, M., Hafer, C., Schneider, A.S., Kielstein, J.T., Al, E., Virus-Associated hemophagocytic syndrome as a major contributor to death in patients with 2009 influenza A H1N1 infection (2011) Crit Care, 15 (2), p. R80; Brisse, E., Ch, W., Andrei, G., Matthys, P., How Viruses Contribute to the Pathogenesis of Hemophagocytic Lymphohistiocytosis (2017) Front Immunol, 8, p. 1102. , Sep; Bouadma, L., Lescure, F.X., Lucet, J.C., Yazdanpanah, Y., Timsit, J.F., Severe SARS-CoV-2 infections: Practical considerations and management strategy for intensivists (2020) Intensive Care Med, , Epub ahead of print; Ronco, C., Ricci, Z., Husain-Syed, F., From Multiple Organ Support Therapy to Extracorporeal Organ Support in Critically Ill Patients (2019) Blood Purif, 48 (2), pp. 99-105; Brodie, D., Vincent, J.L., Brochard, L.J., Combes, A., Ferguson, N.D., Hodgson, C.L., Al, E., Research in Extracorporeal Life Support: A Call to Action (2018) Chest, 153 (4), pp. 788-791. , International ECMO Network (ECMONet), Apr; Husain-Syed, F., Ricci, Z., Brodie, D., Vincent, J.L., Ranieri, V.M., Slutsky, A.S., Al, E., Extracorporeal organ support (ECOS) in critical illness and acute kidney injury: From native to artificial organ crosstalk (2018) Intensive Care Med, 44 (9), pp. 1447-1459. , Sep; Brodie, D., Curtis, J.R., Vincent, J.L., Bakker, J., Brown, C.E., Creteur, J., Al, E., Treatment limitations in the era of ECMO (2017) Lancet Respir Med, 5 (10), pp. 769-770. , participants in the Round Table Conference, Oct; Ma, N., Peek, G.J., Finney, S.J., Griffiths, M.J., Harrison, D.A., Grieve, R., Al, E., Referral to an extracorporeal membrane oxygenation center and mortality among patients with severe 2009 influenza A(H1N1) (2011) JAMA, 306 (15), pp. 1659-1668. , Oct; Delaney, E., Smith, M.J., Harvey, B.T., Pelletier, K.J., Aquino, M.P., Stone, J.M., Al, E., Extracorporeal life support for pandemic influenza: The role of extracorporeal membrane oxygenation in pandemic management (2010) J Extra Corpor Technol, 42 (4), pp. 268-280. , Dec; Fitzgerald, M., Millar, J., Blackwood, B., Davies, A., Brett, S.J., McAuley, D.F., Al, E., Extracorporeal carbon dioxide removal for patients with acute respiratory failure secondary to the acute respiratory distress syndrome: A systematic review (2014) Crit Care, 18 (3), p. 222. , May; Wendon, J., Cordoba, J., Dhawan, A., Larsen, F.S., Manns, M., Samuel, D., Al, E., EASL Clinical Practical Guidelines on the management of acute (fulminant) liver failure (2017) J Hepatol, 66 (5), pp. 1047-1081. , EASL Governing Board representative, May; Ankawi, G., Fan, W., Pomarè Montin, D., Lorenzin, A., Neri, M., Caprara, C., Al, E., A New Series of Sorbent Devices for Multiple Clinical Purposes: Current Evidence and Future Directions (2019) Blood Purif, 47 (1-3), pp. 94-100; Poli, E.C., Rimmelé, T., Schneider, A.G., Hemoadsorption with CytoSorb® (2019) Intensive Care Med, 45 (2), pp. 236-239. , Feb; Ankawi, G., Xie, Y., Yang, B., Xie, Y., Xie, P., Ronco, C., What Have We Learned about the Use of Cytosorb Adsorption Columns? (2019) Blood Purif, 48 (3), pp. 196-202; Girardot, T., Schneider, A., Rimmelé, T., Blood Purification Techniques for Sepsis and Septic AKI (2019) Semin Nephrol, 39 (5), pp. 505-514. , Sep; Ronco, C., Tetta, C., Mariano, F., Wratten, M.L., Bonello, M., Bordoni, V., Al, E., Interpreting the mechanisms of continuous renal replacement therapy in sepsis: The peak concentration hypothesis (2003) Artif Organs, 27 (9), pp. 792-801. , Sep; Honore, P.M., Hoste, E., Molnár, Z., Jacobs, R., Joannes-Boyau, O., Malbrain, M.L., Al, E., Cytokine removal in human septic shock: Where are we and where are we going? (2019) Ann Intensive Care, 9 (1), p. 56. , May; Rimmelé, T., Kellum, J.A., Clinical review: Blood purification for sepsis (2011) Crit Care, 15 (1), p. 205; Reiter, K., Bordoni, V., Dall'Olio, G., Ricatti, M.G., Soli, M., Ruperti, S., Al, E., In vitro removal of therapeutic drugs with a novel adsorbent system (2002) Blood Purif, 20 (4), pp. 380-388; Koch, B., Schult-Dietrich, P., Büttner, S., Dilmaghani, B., Lohmann, D., Baer, P.C., Al, E., Lectin Affinity Plasmapheresis for Middle East Respiratory Syndrome-Coronavirus and Marburg Virus Glycoprotein Elimination (2018) Blood Purif, 46 (2), pp. 126-133","Ronco, C.; Department of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, Viale Rodolfi, 37, Italy; email: cronco@goldnet.it",,S. Karger AG,2535068,,BLPUD,32172242,English,Blood Purif.,Review,Article in Press,Open Access,Scopus,2-s2.0-85082331105,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Hart C.W.,7402569242;,Spiritual Lessons From the Coronavirus Pandemic,2020,Journal of Religion and Health,,,,,,,,10.1007/s10943-020-01011-w,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082311477&doi=10.1007%2fs10943-020-01011-w&partnerID=40&md5=9511a0abeed8aa2164c0480ae47d4e4e,"New York, United States","Hart, C.W., New York, United States",[No abstract available],,,,"Hart, C.W.United States; email: cuh9001@med.cornell.edu",,Springer,224197,,JRHEA,,English,J. Relig. Health,Editorial,Article in Press,Open Access,Scopus,2-s2.0-85082311477,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Xia H., Zhao S., Wu Z., Luo H., Zhou C., Chen X.",57215876862;57215769778;57215873276;57215873291;55735715100;56440360700;,Emergency Caesarean delivery in a patient with confirmed coronavirus disease 2019 under spinal anaesthesia,2020,British Journal of Anaesthesia,,,,,,,,10.1016/j.bja.2020.02.016,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082197695&doi=10.1016%2fj.bja.2020.02.016&partnerID=40&md5=1df648c6b3e656a537141a7e274f29a3,"Department of Anaesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Department of Anaesthesiology, Wuhan Red Cross Hospital, Wuhan, 430015, China; Laboratory of Anaesthesia & Critical Care Medicine, Translational Neuroscience Center, Department of Anaesthesiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China","Xia, H., Department of Anaesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Zhao, S., Department of Anaesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Wu, Z., Department of Anaesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Luo, H., Department of Anaesthesiology, Wuhan Red Cross Hospital, Wuhan, 430015, China; Zhou, C., Laboratory of Anaesthesia & Critical Care Medicine, Translational Neuroscience Center, Department of Anaesthesiology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China; Chen, X., Department of Anaesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China",[No abstract available],anaesthetic management; Caesarean delivery; COVID-19; SARS-CoV-2; spinal anaesthesia,,"Wu, A., Peng, Y., Huang, B., Genome composition and divergence of the novel coronavirus (2019-nCoV) originating in China (2020) Cell Host Microbe, , Advance Access published on February 7; Lu, R., Zhao, X., Li, J., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet, 395, pp. 565-574; Chen, H., Guo, J., Wang, C., Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records (2020) Lancet, , Advance Access published online February 12; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, , Advance Access published online January 24; Chung, M., Bernheim, A., Mei, X., CT imaging features of 2019 novel coronavirus (2019-nCoV) (2020) Radiology, , Advance Access published on February 4; Wang, D., Hu, B., Hu, C., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) JAMA, , Advance Access published on February 7; Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med, , Advance Access published on January 29; Chen, X., Shang, Y., Yao, S., Liu, R., Liu, H., Perioperative care provider's considerations in managing patients with the COVID-19 infections (2020) Transl Perioper Pain Med, , Advance Access published on February 12; Peng, P.W.H., Ho, P.L., Hota, S.S., Outbreak of a new coronavirus: what anaesthetists should know (2020) Br J Anaesth, , [Epub ahead of print]","Zhou, C.; Laboratory of Anaesthesia & Critical Care Medicine, Translational Neuroscience Center, Department of Anaesthesiology, West China Hospital of Sichuan UniversityChina; email: zhouc@163.com",,Elsevier Ltd,70912,,BJANA,32192711,English,Br. J. Anaesth.,Letter,Article in Press,Open Access,Scopus,2-s2.0-85082197695,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhang J., Jia W., Zhu J., Li B., Xing J., Liao M., Qi W.",57200102651;57215873251;57215874117;57194529008;57195052800;7202371672;23111945200;,Insights into the cross-species evolution of 2019 novel coronavirus,2020,Journal of Infection,,,,,,,,10.1016/j.jinf.2020.02.025,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082197631&doi=10.1016%2fj.jinf.2020.02.025&partnerID=40&md5=cb6d09a68be466baeec215a7c62c503b,"National and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control, South China Agricultural University, Guangzhou, 510642, China; Key Laboratory of Zoonoses, Ministry of Agriculture and Rural Affairs, Guangzhou, 510642, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, 510642, China; Key Laboratory of Animal Vaccine Development, Ministry of Agriculture and Rural Affairs, Guangzhou, 510642, China; Key Laboratory of Zoonoses Prevention and Control of Guangdong Province, Guangzhou, 510642, China","Zhang, J., National and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control, South China Agricultural University, Guangzhou, 510642, China, Key Laboratory of Zoonoses Prevention and Control of Guangdong Province, Guangzhou, 510642, China; Jia, W., National and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control, South China Agricultural University, Guangzhou, 510642, China, Key Laboratory of Zoonoses, Ministry of Agriculture and Rural Affairs, Guangzhou, 510642, China, Key Laboratory of Animal Vaccine Development, Ministry of Agriculture and Rural Affairs, Guangzhou, 510642, China, Key Laboratory of Zoonoses Prevention and Control of Guangdong Province, Guangzhou, 510642, China; Zhu, J., National and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control, South China Agricultural University, Guangzhou, 510642, China, Key Laboratory of Zoonoses Prevention and Control of Guangdong Province, Guangzhou, 510642, China; Li, B., National and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control, South China Agricultural University, Guangzhou, 510642, China, Key Laboratory of Zoonoses Prevention and Control of Guangdong Province, Guangzhou, 510642, China; Xing, J., National and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control, South China Agricultural University, Guangzhou, 510642, China, Key Laboratory of Zoonoses Prevention and Control of Guangdong Province, Guangzhou, 510642, China; Liao, M., National and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control, South China Agricultural University, Guangzhou, 510642, China, Key Laboratory of Zoonoses, Ministry of Agriculture and Rural Affairs, Guangzhou, 510642, China, Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, 510642, China, Key Laboratory of Animal Vaccine Development, Ministry of Agriculture and Rural Affairs, Guangzhou, 510642, China, Key Laboratory of Zoonoses Prevention and Control of Guangdong Province, Guangzhou, 510642, China; Qi, W., National and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control, South China Agricultural University, Guangzhou, 510642, China, Key Laboratory of Zoonoses, Ministry of Agriculture and Rural Affairs, Guangzhou, 510642, China, Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, 510642, China, Key Laboratory of Animal Vaccine Development, Ministry of Agriculture and Rural Affairs, Guangzhou, 510642, China, Key Laboratory of Zoonoses Prevention and Control of Guangdong Province, Guangzhou, 510642, China",[No abstract available],,,"Zhang, J., Ma, K., Li, H., Liao, M., Qi, W., The continuous evolution and dissemination of 2019 novel human coronavirus (2020) J Infect; Gorbalenya, A.E., Severe acute respiratory-related coronavirus—The species and its viruses, a statement of the Coronavirus Study Group (2020) BioRxiv; Guan, W., Ni, Z., Hu, Y., Liang, W., Ou, C., He, J., Clinical characteristics of 2019 novel coronavirus infection in China (2020) MedRxiv; Zhou, P., Yang, X., Wang, X., Hu, B., Zhang, L., Zhang, W., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature; Hu, B., Zeng, L., Yang, X., Ge, X., Zhang, W., Li, B., Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus (2017) Plos Pathog, 13 (11); Liu, P., Chen, W., Chen, J., Viral metagenomics revealed sendai virus and coronavirus infection of Malayan Pangolins (Manis javanica) (2019) Viruses, 11 (11). , pii: E979; Lu, G., Wang, Q., Gao, G.F., Bat-to-human: spike features determining ‘host jump’ of coronaviruses SARS-CoV, MERS-CoV, and beyond (2015) Trends Microbiol, 23, pp. 468-478","Liao, M.; National and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control, South China Agricultural UniversityChina; email: mliao@scau.edu.cn",,W.B. Saunders Ltd,1634453,,JINFD,32142930,English,J. Infect.,Letter,Article in Press,Open Access,Scopus,2-s2.0-85082197631,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Ahmad T., Hui J.",57214283384;57214881151;,One Health approach and Coronavirus Disease 2019,2020,Human Vaccines and Immunotherapeutics,,,,,,,,10.1080/21645515.2020.1732168,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082193644&doi=10.1080%2f21645515.2020.1732168&partnerID=40&md5=11da4686b4ca6f48cfa9c7e123417d33,"Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China; Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, China","Ahmad, T., Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China, Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, China; Hui, J., Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China, Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, China",[No abstract available],China; Coronavirus (2019-nCoV) outbreak; One Health approach,,"Häsler, B., Cornelsen, L., Bennani, H., Rushton, J., A review of the metrics for One Health benefits (2014) Rev Sci Tech Off Int Epiz, 33 (2), pp. 453-464; Global status report on noncommunicable diseases 2010 (2011) World Health Organization, , 9789241564229, accessed 2020 Feb09; Novel Coronavirus, , https://www.who.int/emergencies/diseases/novel-coronavirus-2019, accessed 2020 Feb09; Ahmad, T., Khan, M., Khan, F.M., Hui, J., Are we ready for the new fatal Coronavirus: scenario of Pakistan? (2020) Hum Vacc Immunother, pp. 1-3; https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6, accessed 2020 Feb, Coronavirus COVID-19 Global Cases by Johns Hopkins CSSE. [, 27]","Ahmad, T.; Department of Epidemiology and Health Statistics, School of Public Health, Southeast UniversityChina; email: tahmad@seu.edu.cn",,Taylor and Francis Inc.,21645515,,,32186951,English,Hum. Vaccines Immunother.,Article,Article in Press,Open Access,Scopus,2-s2.0-85082193644,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Van Den Heuvel M.,56353722300;,Protecting your staff against coronavirus: Employer's duty of care [Adexa-info: Angestellte vor Corona schützen],2020,Deutsche Apotheker Zeitung,160,10, S85,,,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082190482&partnerID=40&md5=0f21875a38494115e243efb41121acfb,,"Van Den Heuvel, M.",[No abstract available],,,,"Van Den Heuvel, M.",,Deutscher Apotheker Verlag,119857,,DAZEA,,German,Dtsch. Apoth. Ztg.,Short Survey,Final,,Scopus,2-s2.0-85082190482,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhang Z., Xiao K., Zhang X., Roy A., Shen Y.",55601628100;57213592958;57072241300;57215872767;35312068500;,Emergence of SARS-like coronavirus in China: An update,2020,Journal of Infection,,,,,,,,10.1016/j.jinf.2020.03.010,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082187244&doi=10.1016%2fj.jinf.2020.03.010&partnerID=40&md5=ff22437b7f3d1554ae0748ad236b0f75,"College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, 510642, China; Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, Guangzhou, 510642, China; Department of Biotechnology, Lovely Professional UniversityPunjab, India","Zhang, Z., College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China; Xiao, K., College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China; Zhang, X., College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China; Roy, A., Department of Biotechnology, Lovely Professional UniversityPunjab, India; Shen, Y., College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China, Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, 510642, China, Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, Guangzhou, 510642, China",[No abstract available],,,"Wang, R., Zhang, X., Irwin, D.M., Shen, Y., Emergence of SARS-like coronavirus poses new challenge in China (2020) J Infect, 80, pp. 350-371; Tang, J.W., Tambyah, P.A., Hui, D.S.C., Emergence of a novel coronavirus causing respiratory illness from Wuhan, China (2020) J Infect, 80 (3), pp. 350-371; Chan, J.F., Yuan, S., Kok, K.H., To, K.K., Chu, H., Yang, J., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, 395 (10223), pp. 514-523; Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395 (10223), pp. 497-506; Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395 (10223), pp. 507-513; Lee, S.H., The SARS epidemic in Hong Kong (2003) J Epidemiol Community Health, 57 (9), p. 652; Cui, J., Li, F., Shi, Z.L., Origin and evolution of pathogenic coronaviruses (2019) Nat Rev Microbiol, 17 (3), pp. 181-192; Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382 (8), pp. 727-733; Lu, R., Zhao, X., Li, J., Niu, P., Yang, B., Wu, H., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet, 395 (10224), pp. 565-574","Shen, Y.; College of Veterinary Medicine, South China Agricultural UniversityChina; email: shenyy@scau.edu.cn",,W.B. Saunders Ltd,1634453,,JINFD,32173381,English,J. Infect.,Letter,Article in Press,Open Access,Scopus,2-s2.0-85082187244,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Qiu T., Mao T., Wang Y., Zhou M., Qiu J., Wang J., Xu J., Cao Z.",57215877005;57209991137;57215877548;57215874713;56291961100;57215877554;55830926700;55740082900;,Identification of potential cross-protective epitope between a new type of coronavirus (2019-nCoV) and severe acute respiratory syndrome virus,2020,Journal of Genetics and Genomics,,,,,,,,10.1016/j.jgg.2020.01.003,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082184155&doi=10.1016%2fj.jgg.2020.01.003&partnerID=40&md5=4bc0646c7ff3907217aea6559929bdb5,"Shanghai Public Health Clinical Center, Fudan University, Shanghai, China; Department of Gastroenterology, Shanghai 10th People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China; NHC Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, IPB, CAMS-Fondation Mérieux, Institute of Pathogen Biology (IPB), Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China","Qiu, T., Shanghai Public Health Clinical Center, Fudan University, Shanghai, China; Mao, T., Department of Gastroenterology, Shanghai 10th People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China; Wang, Y., Department of Gastroenterology, Shanghai 10th People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China; Zhou, M., Department of Gastroenterology, Shanghai 10th People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China; Qiu, J., Department of Gastroenterology, Shanghai 10th People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China; Wang, J., NHC Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, IPB, CAMS-Fondation Mérieux, Institute of Pathogen Biology (IPB), Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China; Xu, J., Shanghai Public Health Clinical Center, Fudan University, Shanghai, China; Cao, Z., Department of Gastroenterology, Shanghai 10th People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, China",[No abstract available],,,"Hwang, W.C., Lin, Y., Santelli, E., Sui, J., Jaroszewski, L., Stec, B., Farzan, M., Liddington, R.C., Structural basis of neutralization by a human anti-severe acute respiratory syndrome spike protein antibody, 80R (2006) J. Biol. Chem., 281, pp. 34610-34616; Kirchdoerfer, R.N., Cottrell, C.A., Wang, N., Pallesen, J., Yassine, H.M., Turner, H.L., Corbett, K.S., Ward, A.B., Pre-fusion structure of a human coronavirus spike protein (2016) Nature, 531, pp. 118-121; Prabakaran, P., Gan, J., Feng, Y., Zhu, Z., Choudhry, V., Xiao, X., Ji, X., Dimitrov, D.S., Structure of severe acute respiratory syndrome coronavirus receptor-binding domain complexed with neutralizing antibody (2006) J. Biol. Chem., 281, pp. 15829-15836; Qiu, T., Yang, Y., Qiu, J., Huang, Y., Xu, T., Xiao, H., Wu, D., Cao, Z., CE-BLAST makes it possible to compute antigenic similarity for newly emerging pathogens (2018) Nat. Commun., 9, p. 1772; Reguera, J., Santiago, C., Mudgal, G., Ordoño, D., Enjuanes, L., Casasnovas, J.M., Structural bases of coronavirus attachment to host aminopeptidase N and its inhibition by neutralizing antibodies (2012) PLoS Pathog., 8, p. e1002859; Saminathan, M., Chakraborty, S., Tiwari, R., Dhama, K., Verma, A., Coronavirus infection in equines: a review (2014) Asian J. Anim. Vet. Adv., 9, pp. 164-176; Schoeman, D., Fielding, B.C., Coronavirus envelope protein: current knowledge (2019) Virol. J., 16, p. 69; Shu, Y., McCauley, J., GISAID: global initiative on sharing all influenza data - from vision to reality (2017) Euro Surveill., 22, p. 30494; Van Regenmortel, M.H.V., Mapping epitope structure and activity: from one-dimensional prediction to four-dimensional description of antigenic specificity (1996) Methods, 9, pp. 465-472; WHO, Novel Coronavirus-China (2020), https://www.who.int/csr/don/12-january-2020-novel-coronavirus-china/en/; WHO, Pneumonia of Unknown Cause in China (2020), https://www.who.int/csr/don/05-january-2020-pneumonia-of-unkown-cause-china/en/; WHO, Summary of Probable SARS Cases with Onset of Illness from 1 November 2002 to 31 July 2003 (2003), http://www.who.int/csr/sars/country/table2004_04_21/en/index.html; WHO, WHO MERS-CoV Global Summary and Assessment of Risk, August 2018 (WHO/MERS/RA/August18) (2018), http://www.who.int/csr/disease/coronavirus_infections/riskassessment-august-2018.pdf?ua=1; Xu, X., Chen, P., Wang, J., Feng, J., Zhou, H., Li, X., Zhong, W., Hao, P., Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission (2020) Sci. China Life Sci., pp. 1-4; Zhang, Y.Z., Initial Genome Release of Novel Coronavirus (2020), http://virological.org/t/initial-genome-release-of-novel-coronavirus/319?from=groupmessage; Zhou, P., Yang, X., Wang, X., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature","Xu, J.; Shanghai Public Health Clinical Center, Fudan UniversityChina; email: xujianqing@shphc.org.cn",,Institute of Genetics and Developmental Biology,16738527,,,32171450,English,J. Genet. Genomics,Letter,Article in Press,Open Access,Scopus,2-s2.0-85082184155,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhang J., Ma K., Li H., Liao M., Qi W.",57200102651;57215972503;57215971720;7202371672;23111945200;,The continuous evolution and dissemination of 2019 novel human coronavirus,2020,Journal of Infection,,,,,,,3,10.1016/j.jinf.2020.02.001,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082180704&doi=10.1016%2fj.jinf.2020.02.001&partnerID=40&md5=e946e99aeaed87c84bab7cc4302aa9ef,"National and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control, South China Agricultural University, Guangzhou, 510642, China; Key Laboratory of Zoonoses, Ministry of Agriculture and Rural Affairs, Guangzhou, 510642, China; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, 510642, China; Key Laboratory of Animal Vaccine Development, Ministry of Agriculture and Rural Affairs, Guangzhou, 510642, China; Key Laboratory of Zoonoses Prevention and Control of Guangdong Province, Guangzhou, 510642, China","Zhang, J., National and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control, South China Agricultural University, Guangzhou, 510642, China, Key Laboratory of Zoonoses Prevention and Control of Guangdong Province, Guangzhou, 510642, China; Ma, K., National and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control, South China Agricultural University, Guangzhou, 510642, China, Key Laboratory of Zoonoses Prevention and Control of Guangdong Province, Guangzhou, 510642, China; Li, H., National and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control, South China Agricultural University, Guangzhou, 510642, China, Key Laboratory of Zoonoses Prevention and Control of Guangdong Province, Guangzhou, 510642, China; Liao, M., National and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control, South China Agricultural University, Guangzhou, 510642, China, Key Laboratory of Zoonoses, Ministry of Agriculture and Rural Affairs, Guangzhou, 510642, China, Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, 510642, China, Key Laboratory of Animal Vaccine Development, Ministry of Agriculture and Rural Affairs, Guangzhou, 510642, China, Key Laboratory of Zoonoses Prevention and Control of Guangdong Province, Guangzhou, 510642, China; Qi, W., National and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control, South China Agricultural University, Guangzhou, 510642, China, Key Laboratory of Zoonoses, Ministry of Agriculture and Rural Affairs, Guangzhou, 510642, China, Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, 510642, China, Key Laboratory of Animal Vaccine Development, Ministry of Agriculture and Rural Affairs, Guangzhou, 510642, China, Key Laboratory of Zoonoses Prevention and Control of Guangdong Province, Guangzhou, 510642, China",[No abstract available],,,"Wang, R., Zhang, X., Irwin, D.M., Shen, Y., Emergence of SARS-like Coronavirus poses new challenge in China (2020) J Infect; Su, S., Wong, G., Shi, W., Epidemiology, genetic recombination, and pathogenesis of coronaviruses (2016) Trends Microbiol, 24 (6), pp. 490-502; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet; Chan, J.F., Yuan, S., Kok, K.H., To, K.K., Chu, H., Yang, J., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet; Lu, G., Wang, Q., Gao, G.F., Bat-to-human: spike features determining ‘host jump’ of coronaviruses SARS-CoV, MERS-CoV, and beyond (2015) Trends Microbiol, 23, pp. 468-478; Zhou, P., Yang, X., Wang, X., Hu, B., Zhang, L., Zhang, W., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature; Hu, B., Zeng, L., Yang, X., Ge, X., Zhang, W., Li, B., Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of Sars coronavirus (2017) Plos Pathog, 13 (11); Shen, X., Sabir, J.S.M., Irwin, D.M., Shen, Y., Vaccine against Middle East respiratory syndrome coronavirus (2019) Lancet Infect Dis, 19 (10), pp. 1053-1054; Zhou, P., Fan, H., Lan, T., Yang, X., Shi, W., Zhang, W., Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin (2018) Nature, 556 (7700), pp. 255-258; Carroll, D., Daszak, P., Wolfe, N.D., Gao, G.F., Morzaria, S., Pablos-Méndez, A., The global virome project (2018) Science, 359 (6378), pp. 872-874","Liao, M.; National and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control, South China Agricultural UniversityChina; email: mliao@scau.edu.cn",,W.B. Saunders Ltd,1634453,,JINFD,32092385,English,J. Infect.,Letter,Article in Press,Open Access,Scopus,2-s2.0-85082180704,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Chan K.W., Wong V.T., Tang S.C.W.",54879476100;57211752605;7403437082;,"COVID-19: An Update on the Epidemiological, Clinical, Preventive and Therapeutic Evidence and Guidelines of Integrative Chinese-Western Medicine for the Management of 2019 Novel Coronavirus Disease",2020,American Journal of Chinese Medicine,,,,,,,1,10.1142/S0192415X20500378,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082179878&doi=10.1142%2fS0192415X20500378&partnerID=40&md5=cd860c9262f559efd8412cf678307cc1,"Department of Medicine, University of Hong Kong, 4/F Professorial Block, 102 Pokfulam Road, Hong Kong; School of Chinese Medicine, University of Hong Kong, Hong Kong","Chan, K.W., Department of Medicine, University of Hong Kong, 4/F Professorial Block, 102 Pokfulam Road, Hong Kong; Wong, V.T., School of Chinese Medicine, University of Hong Kong, Hong Kong; Tang, S.C.W., Department of Medicine, University of Hong Kong, 4/F Professorial Block, 102 Pokfulam Road, Hong Kong","As of 22 February 2020, more than 77662 cases of confirmed COVID-19 have been documented globally with over 2360 deaths. Common presentations of confirmed cases include fever, fatigue, dry cough, upper airway congestion, sputum production, shortness of breath, myalgia/arthralgia with lymphopenia, prolonged prothrombin time, elevated C-reactive protein, and elevated lactate dehydrogenase. The reported severe/critical case ratio is approximately 7-10% and median time to intensive care admission is 9.5-10.5 days with mortality of around 1-2% varied geographically. Similar to outbreaks of other newly identified virus, there is no proven regimen from conventional medicine and most reports managed the patients with lopinavir/ritonavir, ribavirin, beta-interferon, glucocorticoid and supportive treatment with remdesivir undergoing clinical trial. In China, Chinese medicine is proposed as a treatment option by national and provincial guidelines with substantial utilization. We reviewed the latest national and provincial clinical guidelines, retrospective cohort studies, and case series regarding the treatment of COVID-19 by add-on Chinese medicine. We have also reviewed the clinical evidence generated from SARS and H1N1 management with hypothesized mechanisms and latest in silico findings to identify candidate Chinese medicines for the consideration of possible trials and management. Given the paucity of strongly evidence-based regimens, the available data suggest that Chinese medicine could be considered as an adjunctive therapeutic option in the management of COVID-19. © 2020 World Scientific Publishing Company. 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Drugs, , http://kns.cnki.net/kcms/detail/12.1108.R.20200216.2044.002.html; Zhaori, G., Antiviral treatment of SARS: Can we draw any conclusions? (2003) CMAJ, 169, pp. 1165-1166; Zheng, W., Zhang, J., Yang, F., Wang, Y.L., Qingquan, Boli, Z., A review on the diagnosis and treatment guidelines of pneumonia in the prevention and treatment of new coronavirus by traditional Chinese medicine (2020) J. Tradit. Chin. Med., , https://kns8.cnki.net/KCMS/detail/11.2166.r.20200206.1113.002.html; Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., Zhao, X., Tan, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N. Engl. J. Med., 382, pp. 727-733; Zong, Y., Ding, M., Jia, K., Ma, S., Ju, W., Exploring the active compounds of Da-yuan-yin in treatment of novel coronavirus (2019-nCoV) pneumonia based on network pharmacology and molecular docking method (2020) Chin. Tradit. Herb. Drugs, , https://kns8.cnki.net/KCMS/detail/12.1108.r.20200209.1038.002.html; Zou, L., Ruan, F., Huang, M., Liang, L., Huang, H., Hong, Z., Yu, J., Wu, J., SARS-CoV-2 viral load in upper respiratory specimens of infected patients (2020) N. Engl. J. Med.","Wong, V.T.; School of Chinese Medicine, University of Hong Kong, 10 Sasson Road, Hong Kong; email: vcwwong@hku.hk",,World Scientific Publishing Co. Pte Ltd,0192415X,,AJCMB,32164424,English,Am. J. Chin. Med.,Article,Article in Press,Open Access,Scopus,2-s2.0-85082179878,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Thompson L.A., Rasmussen S.A.",57199717016;57215316512;,What Does the Coronavirus Disease 2019 (COVID-19) Mean for Families?,2020,JAMA Pediatrics,,,,,,,,10.1001/jamapediatrics.2020.0828,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082127487&doi=10.1001%2fjamapediatrics.2020.0828&partnerID=40&md5=04bee4e54db729ef34b5f73c8c640785,"Department of Pediatrics, University of Florida College of Medicine, Gainesville, United States; Department of Health Outcomes and Biomedical Informatics, University of Florida College of Medicine, Gainesville, United States; Department of Epidemiology, University of Florida College of Public Health and Health Professions and College of Medicine, Gainesville, United States","Thompson, L.A., Department of Pediatrics, University of Florida College of Medicine, Gainesville, United States, Department of Health Outcomes and Biomedical Informatics, University of Florida College of Medicine, Gainesville, United States; Rasmussen, S.A., Department of Pediatrics, University of Florida College of Medicine, Gainesville, United States, Department of Epidemiology, University of Florida College of Public Health and Health Professions and College of Medicine, Gainesville, United States",[No abstract available],,,,,,American Medical Association,21686203,,,32167533,English,JAMA Pediatr.,Note,Article in Press,Open Access,Scopus,2-s2.0-85082127487,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, [No author name available],[No author id available],"""When China gets a cold, India must sneeze"": Update on the risk of drug shortages due to the coronavirus crisis [„Wenn China sich erkältet, muss Indien niesen“: Update zur Gefahr von Arzneimittelverknappungen durch die Coronoavirus-Krise]",2020,Deutsche Apotheker Zeitung,160,9,12,,,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082127454&partnerID=40&md5=7c247ec9ec1593b40fd0ec3cb24e6834,,,[No abstract available],,,,,,Deutscher Apotheker Verlag,119857,,DAZEA,,German,Dtsch. Apoth. Ztg.,Short Survey,Final,,Scopus,2-s2.0-85082127454,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Sarma P., Prajapat M., Avti P., Kaur H., Kumar S., Medhi B.",35915494500;57205574202;8294435500;57211922804;56768466400;6602803991;,Therapeutic options for the treatment of 2019-novel coronavirus: An evidence-based approach,2020,Indian Journal of Pharmacology,52,1,,1,5,,,10.4103/ijp.IJP_119_20,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082092375&doi=10.4103%2fijp.IJP_119_20&partnerID=40&md5=192804b65f1a8bf6507ce78021ea643c,"Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India; Department of Biophysics, Postgraduate Institute of Medical Education and Research, Chandigarh, India","Sarma, P., Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India; Prajapat, M., Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India; Avti, P., Department of Biophysics, Postgraduate Institute of Medical Education and Research, Chandigarh, India; Kaur, H., Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India; Kumar, S., Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India; Medhi, B., Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh, India",[No abstract available],,antivirus agent; baricitinib; chloroquine; corticosteroid; immunoglobulin; immunomodulating agent; interferon; nucleoside analog; proteinase inhibitor; remdesivir; sialidase inhibitor; antiviral therapy; biological therapy; China; coronavirus disease 2019; Coronavirus infection; corticosteroid therapy; Editorial; evidence based practice; host directed therapy; human; immunotherapy; nonhuman; virus pneumonia,"Graham, R.L., Donaldson, E.F., Baric, R.S., A decade after SARS: Strategies for controlling emerging coronaviruses (2013) Nat Rev Microbiol, 11, pp. 836-848; SARS (Severe Acute Respiratory Syndrome), , https://www.who.int/ith/diseases/sars/en, World Health Organization, [Last accessed on 2020 Feb 13]; (2019) Centers for Disease Control and Prevention, , https://www.cdc.gov/coronavirus/mers/about/index.html, Centers for Disease Control and Prevention. About MERS, [Last accessed on 2020 Feb 13]; https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200212-sitrep-23-ncov.pdf, [Last accessed on 2020 Feb 13]; Battegay, M., Kuehl, R., Tschudin-Sutter, S., Hirsch, H.H., Widmer, A.F., Neher, R.A., 2019-novel coronavirus (2019-nCoV): Estimating the case fatality rate-A word of caution (2020) Swiss Med Wkly, 150, p. w20203; Zumla, A., Chan, J.F., Azhar, E.I., Hui, D.S., Yuen, K.Y., Coronaviruses-drug discovery and therapeutic options (2016) Nat Rev Drug Discov, 15, pp. 327-347; Li, G., Clercq, E.D., Therapeutic options for the 2019 novel coronavirus (2019-nCoV) (2020) Nat Rev Drug Discov, 19, pp. 149-150; Tai, D.Y., Pharmacologic treatment of SARS: Current knowledge and recommendations (2007) Ann Acad Med Singapore, 36, pp. 438-443; Neuraminidase inhibitors for treatment of influenza A and B infections (1999) MMWR Recomm Rep, 48, pp. 1-9; Bleibtreu, A., Jaureguiberry, S., Houhou, N., Boutolleau, D., Guillot, H., Vallois, D., Clinical management of respiratory syndrome in patients hospitalized for suspected Middle East respiratory syndrome coronavirus infection in the Paris area from 2013 to 2016 (2018) BMC Infect Dis, 18, p. 331; Al-Abdely, H.M., Midgley, C.M., Alkhamis, A.M., Abedi, G.R., Lu, X., Binder, A.M., Middle East respiratory syndrome coronavirus infection dynamics and antibody responses among clinically diverse patients, Saudi Arabia (2019) Emerg Infect Dis, 25, pp. 753-766; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506; Dayer, M.R., Taleb-Gassabi, S., Dayer, M.S., Lopinavir; A potent drug against coronavirus infection: Insight from molecular docking study (2017) Arch Clin Infect Dis, 12, p. e13823. , http://archcid.com/en/articles/13823.html, [Last accessed on 2020 Feb 12]; Nukoolkarn, V., Lee, V.S., Malaisree, M., Aruksakulwong, O., Hannongbua, S., Molecular dynamic simulations analysis of ritonavir and lopinavir as SARS-CoV 3CL (pro) inhibitors (2008) J Theor Biol, 254, pp. 861-867; Chu, C.M., Cheng, V.C., Hung, I.F., Wong, M.M., Chan, K.H., Chan, K.S., Role of lopinavir/ritonavir in the treatment of SARS: Initial virological and clinical findings (2004) Thorax, 59, pp. 252-256; Oldfield, V., Plosker, G.L., Lopinavir/ritonavir: A review of its use in the management of HIV infection (2006) Drugs, 66, pp. 1275-1299; Jin, Y.H., Cai, L., Cheng, Z.S., Cheng, H., Deng, T., Fan, Y.P., A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version) (2020) Mil Med Res, 7, p. 4; Clinical Management of Severe Acute Respiratory Infection When Novel Coronavirus (NCoV) Infection Is Suspected, , https://www.who.int/publications-detail/clinicalmanagement-of-severe-acute-respiratory-infection-when-novel-coronavirus-(ncov)-infection-is-suspected, [Last accessed on 2020 Feb 12]; Russell, C.D., Millar, J.E., Baillie, J.K., Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury (2020) Lancet, 395, pp. 473-475; Zhao, Z., Zhang, F., Xu, M., Huang, K., Zhong, W., Cai, W., Description and clinical treatment of an early outbreak of severe acute respiratory syndrome (SARS) in Guangzhou, PR China (2003) J Med Microbiol, 52, pp. 715-720; Loutfy, M.R., Blatt, L.M., Siminovitch, K.A., Ward, S., Wolff, B., Lho, H., Interferon alfacon-1 plus corticosteroids in severe acute respiratory syndrome: A preliminary study (2003) JAMA, 290, pp. 3222-3228; Lau, A.C., Yam, L.Y., So, L.K., Management of critically Ill patients with severe acute respiratory syndrome (SARS) (2004) Int J Med Sci, 1, pp. 1-10; Tsang, K., Zhong, N.S., SARS: Pharmacotherapy (2003) Respirology, 8, pp. S25-30; Zumla, A., Hui, D.S., Azhar, E.I., Memish, Z.A., Maeurer, M., Reducing mortality from 2019-nCoV: Host-directed therapies should be an option (2020) Lancet, 395, pp. e35-e36; Te Velthuis, A.J., Vanden Worm, S.H., Sims, A.C., Baric, R.S., Snijder, E.J., Van Hemert, M.J., Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture (2010) PLoS Pathog, 6, p. e1001176; https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200128-sitrep-8-ncov-cleared.pdf, [Last accessed on 2020 Feb 12]; https://www.who.int/docs/default-source/coronaviruse/clinical-management-of-novel-cov.pdf, [Last accessed on 2020 Feb 12]; Wang, Z., Chen, X., Lu, Y., Chen, F., Zhang, W., Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined Chinese and Western medicine treatment [published online ahead of print, 2020 Feb 9] (2020) Biosci Trends, , 10.5582/bst.2020.01030; Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study (2020) Lancet, 395, pp. 507-513; Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan China (2020) JAMA, , https://jamanetwork.com/journals/jama/fullarticle/2761044, [Last cited on 2020 Mar 04]; Zhang, Z., Li, X., Zhang, W., Shi, Z.L., Zheng, Z., Wang, T., Clinical features and treatment of 2019-nCov pneumonia patients in Wuhan: Report of a couple cases (2020) Virol Sin; Kui, L., Fang, Y.Y., Deng, Y., Liu, W., Wang, M.F., Ma, J.P., Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province [published online ahead of print, 2020 Feb 7] (2020) Chin Med J (Engl), , 10.1097/CM9.0000000000000744; Wang, M., Cao, R., Zhang, L., Yang, X., Liu, J., Xu, M., Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro (2020) Cell Res, 30, pp. 269-271; Warren, T.K., Jordan, R., Lo, M.K., Ray, A.S., MacKman, R.L., Soloveva, V., Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys (2016) Nature, 531, pp. 381-385; Vincent, M.J., Bergeron, E., Benjannet, S., Erickson, B.R., Rollin, P.E., Ksiazek, T.G., Chloroquine is a potent inhibitor of SARS coronavirus infection and spread (2005) Virol J, 2, p. 69; Hoffmann, M., Kleine-Weber, H., Krüger, N., Müller, M., Drosten, C., Pöhlmann, S., The novel coronavirus 2019 (2019-nCoV) uses the SARS-coronavirus receptor ACE2 and the cellular protease TMPRSS2 for entry into target cells [Internet] (2020) Molecular Biology, , http://biorxiv.org/lookup/doi/10.1101/2020.01.31.929042, [Last cited on 2020 Mar 04]; Richardson, P., Griffin, I., Tucker, C., Smith, D., Oechsle, O., Phelan, A., Baricitinib as potential treatment for 2019-nCoV acute respiratory disease (2020) Lancet, 395, pp. e30-e31","Medhi, B.; Department of Pharmacology, Postgraduate Institute of Medical Education and ResearchIndia; email: drbikashus@yahoo.com",,Wolters Kluwer Medknow Publications,2537613,,INJPD,32201439,English,Indian J. Pharmacol.,Editorial,Final,,Scopus,2-s2.0-85082092375,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Lou X.X., Shi C.X., Zhou C.C., Tian Y.S.",57215844768;57215844520;57210934132;57215844706;,Three children who recovered from novel coronavirus 2019 pneumonia,2020,Journal of Paediatrics and Child Health,,,,,,,,10.1111/jpc.14871,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082091016&doi=10.1111%2fjpc.14871&partnerID=40&md5=e568a50e032fa3900bb69c05aaf5ec91,"Children's Hospital affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou, China","Lou, X.X., Children's Hospital affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou, China; Shi, C.X., Children's Hospital affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou, China; Zhou, C.C., Children's Hospital affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou, China; Tian, Y.S., Children's Hospital affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou, China",[No abstract available],,,"Lu, H., Stratton, C.W., Tang, Y.W., Outbreak of pneumonia of unknown etiology in Wuhan China: The mystery and the miracle (2020) J. Med. Virol., 92, pp. 401-402; Hui, D.S., Azhar, E., Madani, T.A., The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health: The latest 2019 novel coronavirus outbreak in Wuhan, China (2020) Int. J. Infect. Dis., 91, pp. 264-266; http://wjw.wuhan.gov.cn/front/web/showDetail/2020012009077, Report of Novel Coronavirus-Infected Pneumonia in China, 2020. Available from, [accessed 31 January 2020]; Paules, C.I., Marston, H.D., Fauci, A.S., Coronavirus infections—More than just the common cold (2020) JAMA, 323, p. 707; http://wjw.wuhan.gov.cn/front/web/showDetail/2019123108989, Report of Clustering Pneumonia of Unknown Etiology in Wuhan City, 2019. Available from, [Accessed 31 January 2020]; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study (2020) Lancet, 395, pp. 507-513; Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan (2020) JAMA, , https://doi.org/10.1001/jama.2020.1585; Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N. Engl. J. Med., , https://doi.org/10.1056/NEJMoa2001316; Wang, C., Horby, P.W., Hayden, F.G., Gao, G.F., A novel coronavirus outbreak of global health concern (2020) Lancet, 395, pp. 470-473",,,Blackwell Publishing,10344810,,JPCHE,,English,J. Paediatr. Child Health,Article,Article in Press,Open Access,Scopus,2-s2.0-85082091016,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Kramer A.,57207908385;,Coronavirus infections: Which mask really protects? [Coronavirus-Infektionen: Welche Maske schützt wirklich?],2020,Deutsche Apotheker Zeitung,160,8, S78,,,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082082614&partnerID=40&md5=c271043f80590a3ecab87bee0c6d0337,"Institut für Hygiene und Umweltmedizin, Uni Greifswald, Germany","Kramer, A., Institut für Hygiene und Umweltmedizin, Uni Greifswald, Germany",[No abstract available],,,,"Kramer, A.; Institut für Hygiene und Umweltmedizin, Uni GreifswaldGermany",,Deutscher Apotheker Verlag,119857,,DAZEA,,German,Dtsch. Apoth. Ztg.,Letter,Final,,Scopus,2-s2.0-85082082614,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhou P., Huang Z., Xiao Y., Huang X., Fan X.-G.",57215843743;57215839826;57215839632;35210054200;7403393592;,Protecting Chinese Healthcare Workers while Combating the 2019 Novel Coronavirus,2020,Infection Control and Hospital Epidemiology,,,,,,,1,10.1017/ice.2020.60,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082079576&doi=10.1017%2fice.2020.60&partnerID=40&md5=1dda966f60feac7a08e5a66d6f5a22c3,"Infection Control Centre, Xiangya Hospital, Central South University, Changsha, 410008, China; Hunan Key Laboratory of Viral Hepatitis, Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, 410008, China; Burnet Institute, St Vincent's Hospital Melbourne, University of Melbourne, Melbourne, 3065, Australia","Zhou, P., Infection Control Centre, Xiangya Hospital, Central South University, Changsha, 410008, China; Huang, Z., Hunan Key Laboratory of Viral Hepatitis, Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, 410008, China; Xiao, Y., Hunan Key Laboratory of Viral Hepatitis, Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, 410008, China, Burnet Institute, St Vincent's Hospital Melbourne, University of Melbourne, Melbourne, 3065, Australia; Huang, X., Infection Control Centre, Xiangya Hospital, Central South University, Changsha, 410008, China; Fan, X.-G., Hunan Key Laboratory of Viral Hepatitis, Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, 410008, China",[No abstract available],,,"Chan, J.F., Yuan, S., Kok, K.H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: A study of a family cluster (2020) LANCET; (2003) National Health Commission of the People's Republic of China Website, , http://www.nhc.gov.cn/wjw/zcjd/201304/2e198946322b4b9ab3972565ff3db8c6.shtml, General epidemic situation of SARS in China, May 29, Published 2003. Accessed Feb 20, 2020; The epidemiological Characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China (2020) Chin J Epidemiol, 42, pp. 145-151. , The Novel Coronavirus Pneumonia Emergency Response Epidemiology Team, Chinese Center for Disease Control and Prevention; National Health Commission of the People's Republic of China Website, , http://www.nhc.gov.cn/yzygj/s7653p/202002/d4b895337e19445f8d728fcaf1e3e13a.shtml, Diagnosis and treatment program of novel coronavirus pneumonia (The Fifth Edition), Published 2020. Accessed Feb 20, 2020; Nosocomial Infection Outbreak in Wuhan Mental Health Center, about 80 Healthcare Workers and Patients Were Infected with Novel Coronavirus Pneumonia, , http://society.people.com.cn/n1/2020/0209/c1008-31577664.html, Feb 8, 2020. Peoples Daily website, Published 2020. Accessed Feb 20, 2020","Fan, X.-G.; Infection Control Centre, Xiangya Hospital, Central South UniversityChina; email: xgfan@hotmail.com",,Cambridge University Press,0899823X,,ICEPE,32131906,English,Infect. Control Hosp. Epidemiol.,Letter,Article in Press,Open Access,Scopus,2-s2.0-85082079576,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Arabi Y.M., Murthy S., Webb S.",7004353546;36247670800;24774575800;,"Correction to: COVID-19: a novel coronavirus and a novel challenge for critical care (Intensive Care Medicine, (2020), 10.1007/s00134-020-05955-1)",2020,Intensive Care Medicine,,,,,,,,10.1007/s00134-020-06009-2,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082050136&doi=10.1007%2fs00134-020-06009-2&partnerID=40&md5=f02bb7605ae65d5fe889a677672507db,"Intensive Care Department, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; King Saud Bin Abdulaziz University for Health Sciences, ICU 1425, PO Box 22490, Riyadh, 11426, Saudi Arabia; University of British Columbia, Vancouver, BC V6H 3V4, Canada; School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia","Arabi, Y.M., Intensive Care Department, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia, King Saud Bin Abdulaziz University for Health Sciences, ICU 1425, PO Box 22490, Riyadh, 11426, Saudi Arabia; Murthy, S., University of British Columbia, Vancouver, BC V6H 3V4, Canada; Webb, S., School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia","the original version of this article unfortunately contained a mistake. there was an error in table one: in the last row, second column the part “still being defined to” should be crossed out. the correct table 1 can be found below. we apologize for the mistake. © 2020, Springer-Verlag GmbH Germany, part of Springer Nature.",,erratum,,"Arabi, Y.M.; Intensive Care Department, Ministry of National Guard Health AffairsSaudi Arabia; email: arabi@ngha.med.sa",,Springer,3424642,,ICMED,32189010,English,Intensive Care Med.,Erratum,Article in Press,Open Access,Scopus,2-s2.0-85082050136,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Leung C.,57209301345;,The difference in the incubation period of 2019 novel coronavirus (SARS-CoV-2) infection between travelers to Hubei and non-travelers: The need of a longer quarantine period,2020,Infection Control and Hospital Epidemiology,,,,,,,,10.1017/ice.2020.81,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082033738&doi=10.1017%2fice.2020.81&partnerID=40&md5=21ac030522a43309c0e22d0227ae7e83,"Deakin University, 221 Burwood Highway3125, Australia","Leung, C., Deakin University, 221 Burwood Highway3125, Australia","Data collected from the individual cases reported by the media were used to estimate the distribution of the incubation period of travelers to Hubei and non-travelers. Upon the finding of longer and more volatile incubation period in travelers, the duration of quarantine should be extended to three weeks. © 2020 by The Society for Healthcare Epidemiology of America. All rights reserved.",COVID-19; Incubation period; SARS-CoV-2; Travelers,article; controlled study; human; incubation time; nonhuman; quarantine; SARS coronavirus; travel,"Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med; Ji, W., Wang, W., Zhao, X., Homologous recombination within the spike glycoprotein of the newly identified coronavirus may boost cross-species transmission from snake to human (2020) J Med Virol; Chan, J.F., Yuan, S., Kok, K., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: A study of a family cluster (2020) Lancet; Guan, W., Ni, Z., Hu, Y., Clinical characteristics of 2019 novel coronavirus infection in China (2020) MedRxiv; Reich, N.G., Lessler, J., Cummings, D.A.T., Estimating incubation period distributions with coarse data (2009) Stat Med, 28 (22), pp. 2769-2784; (2020) State Council Information Office Press Conference, , http://www.nhc.gov.cn/xwzb/webcontroller.do?titleSeq=11209&gecstype=1, (January 26). Accessed 9 February 2020; Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med; Backer, J.A., Klinkenberg, D., Wallinga, J., Incubation period of 2019 novel coronavirus (COVID-19) infections among travellers from Wuhan, China (2020) Eurosurveil","Leung, C.; Deakin University, 221 Burwood Highway, Australia; email: char.leung@deakin.edu.au",,Cambridge University Press,0899823X,,ICEPE,32183920,English,Infect. Control Hosp. Epidemiol.,Article,Article in Press,Open Access,Scopus,2-s2.0-85082033738,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Li F., Feng Z.C., Shi Y.",57215697596;7403442975;35234817800;,Proposal for prevention and control of the 2019 novel coronavirus disease in newborn infants,2020,Archives of Disease in Childhood: Fetal and Neonatal Edition,,,318996,,,,,10.1136/archdischild-2020-318996,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082033625&doi=10.1136%2farchdischild-2020-318996&partnerID=40&md5=0f715bffcb45cec6490ada0b63990b19,"Department of Neonatology, Chongqing Medical University Affiliated, Children's Hospital, Chongqing, China; National Clinical Research Center for Child Health and Disorders, Chongqing, China; Bayi Children's Hospital, Seventh Medical Center of Chinese, PLA General Hospital, Beijing, 400014, China","Li, F., Department of Neonatology, Chongqing Medical University Affiliated, Children's Hospital, Chongqing, China, National Clinical Research Center for Child Health and Disorders, Chongqing, China; Feng, Z.C., Bayi Children's Hospital, Seventh Medical Center of Chinese, PLA General Hospital, Beijing, 400014, China; Shi, Y., Department of Neonatology, Chongqing Medical University Affiliated, Children's Hospital, Chongqing, China, National Clinical Research Center for Child Health and Disorders, Chongqing, China",[No abstract available],infectious diseases; Neonatology,,"Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382, pp. 727-733. , http://dx.doi.org/10.1056/NEJMoa2001017; Fang, F., Luo, X.P., Facing the pandemic of 2019 novel coronavirus infections: The pediatric perspectives (2020) ZhonghuaErKeZaZhi, 58, p. 1; Shek, C.C., Ng, P.C., Fung, G.P.G., Infants born to mothers with severe acute respiratory syndrome (2003) Pediatrics, 112. , http://dx.doi.org/10.1542/peds.112.4.e254, e254; (2020) Interim Clinical Guidance for Management of Patients with Confirmed 2019 Novel Coronavirus (2019-nCoV) Infection, , World Health Organization.,. Available: http://www.cdc.gov/coronavirus/2019-ncov/hcp/clinical-guidance-management-patients.htm","Feng, Z.C.; Bayi Children's Hospital, Seventh Medical Center of Chinese, PLA General HospitalChina; email: zhichunfeng81@163.com",,BMJ Publishing Group,13592998,,ADCHA,32132140,English,Arch. Dis. Child. Fetal Neonatal Ed.,Letter,Article in Press,Open Access,Scopus,2-s2.0-85082033625,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Diao M., Zhang S., Chen D., Hu W.",55630446600;57215062681;55724974400;57215823601;,The novel coronavirus (COVID-19) infection in Hangzhou: An experience to share,2020,Infection Control and Hospital Epidemiology,,,,,,,,10.1017/ice.2020.62,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082033605&doi=10.1017%2fice.2020.62&partnerID=40&md5=f129ebff09ff1992251b18f694cfbce0,"Department of Critical Care Medicine, Affiliated Hangzhou First People's Hospital, Zhejiang University, School of Medicine, Zhejiang, Hangzhou, China; Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China; Department of Critical Care Medicine, Affiliated Hangzhou First People's Hospital, Zhejiang University, School of Medicine, Zhejiang, Hangzhou, 052020, China","Diao, M., Department of Critical Care Medicine, Affiliated Hangzhou First People's Hospital, Zhejiang University, School of Medicine, Zhejiang, Hangzhou, China; Zhang, S., Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China; Chen, D., Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China; Hu, W., Department of Critical Care Medicine, Affiliated Hangzhou First People's Hospital, Zhejiang University, School of Medicine, Zhejiang, Hangzhou, China, Department of Critical Care Medicine, Affiliated Hangzhou First People's Hospital, Zhejiang University, School of Medicine, Zhejiang, Hangzhou, 052020, China",[No abstract available],,,"Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan China[J] (2020) Lancet; Health Commission of Zhejiang Province Webside, , http://www.zjwjw.gov.cn/art/2020/2/21/art120219441958075.html, Epidemic situation of new coronavirus pneumonia in Zhejiang province, 2020, Published 2020. Accessed February 21, 2020; Kamvar, Z.N., Cai, J., Pulliam, J., Schumacher, J., Jombart, T., Epidemic curves made easy using the R package incidence[J] (2019) F1000Res, 8, p. 139","Hu, W.; Department of Critical Care Medicine, Affiliated Hangzhou First People's Hospital, Zhejiang University, School of MedicineChina; email: paolohu929@zju.edu.cn",,Cambridge University Press,0899823X,,ICEPE,32131914,English,Infect. Control Hosp. Epidemiol.,Letter,Article in Press,Open Access,Scopus,2-s2.0-85082033605,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Lana R.M., Coelho F.C., Gomes M.F.D.C., Cruz O.G., Bastos L.S., Villela D.A.M., Codeço C.T.",55510836500;35870801200;56402518600;23989979100;55648716900;57193973109;6602352568;,The novel coronavirus (SARS-CoV-2) emergency and the role of timely and effective national health surveillance [Emergência do novo coronavírus (SARS-CoV-2) e o papel de uma vigilância nacional em saúde oportuna e efetiva],2020,Cadernos de saude publica,36,3,,e00019620,,,,10.1590/0102-311x00019620,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082024936&doi=10.1590%2f0102-311x00019620&partnerID=40&md5=04e0e18267461900a9b247906673fc26,"Programa de Computação Científica, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil; Escola de Matemática Aplicada, Fundação Getúlio Vargas, Rio de Janeiro, Brazil","Lana, R.M., Programa de Computação Científica, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil; Coelho, F.C., Escola de Matemática Aplicada, Fundação Getúlio Vargas, Rio de Janeiro, Brazil; Gomes, M.F.D.C., Programa de Computação Científica, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil; Cruz, O.G., Programa de Computação Científica, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil; Bastos, L.S., Programa de Computação Científica, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil; Villela, D.A.M., Programa de Computação Científica, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil; Codeço, C.T., Programa de Computação Científica, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil",[No abstract available],,"COVID-19; Brazil; Coronavirus infection; epidemic; health survey; human; virology; virus pneumonia; Brazil; Coronavirus Infections; Disease Outbreaks; Humans; Pneumonia, Viral; Public Health Surveillance",,,,NLM (Medline),16784464,,,32187288,English; Portuguese,Cad Saude Publica,Article,Final,Open Access,Scopus,2-s2.0-85082024936,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Li B., Si H.-R., Zhu Y., Yang X.-L., Anderson D.E., Shi Z.-L., Wang L.-F., Zhou P.",57215828411;57215134494;57216095025;35811468700;25631949200;7403733955;35243718700;56996599500;,"Correction to: 'Discovery of Bat Coronaviruses through Surveillance and Probe Capture-Based Next-Generation Sequencing' Volume 5, no. 1, e00807-19, 2020, [DOI: 10.1128/mSphere.00807-19]",2020,mSphere,5,2, e00170,,,,,10.1128/MSPHERE.00170-20,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082021013&doi=10.1128%2fMSPHERE.00170-20&partnerID=40&md5=f18c39bc2d81373199e1f5500d1253e6,"CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; University of Chinese Academy of Sciences, Beijing, China; Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore","Li, B., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Si, H.-R., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China, University of Chinese Academy of Sciences, Beijing, China; Zhu, Y., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Yang, X.-L., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Anderson, D.E., Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore; Shi, Z.-L., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Wang, L.-F., Programme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore, Singapore; Zhou, P., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China","Volume 5, no. 1, e00807-19, 2020, https://doi.org/10.1128/mSphere.00807-19. Page 9: the following sentence should be added to the ""Data availability"" paragraph: ""Raw next-generation sequencing data have been deposited in the NCBI SRA database under accession no. SRR11085733 to SRR11085741."" © 2020 Li et al.",,erratum,,"Wang, L.-F.; Programme in Emerging Infectious Diseases, Duke-NUS Medical SchoolSingapore; email: linfa.wang@duke-nus.edu.sg",,American Society for Microbiology,23795042,,,32188751,English,mSphere,Erratum,Final,Open Access,Scopus,2-s2.0-85082021013,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, da Silva A.A.M.,35553371900;,On the possibility of interrupting the coronavirus (Covid-19) epidemic based on the best available scientific evidence [Sobre a possibilidade de interrupção da epidemia pelo coronavírus (Covid-19) com base nas melhores evidências científicas disponíveis],2020,Revista Brasileira de Epidemiologia,23,, E200021,,,,,10.1590/1980-549720200021,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082013854&doi=10.1590%2f1980-549720200021&partnerID=40&md5=f841a3f5a4411462a5af0c86c5ac6705,"Departamento de Saúde Pública, Centro de Ciências Biológicas e da Saúde, Universidade Federal do Maranhão, Rua Barão de Itapary, 155, Centro, São Luís, MA CEP: 65020-070, Brazil","da Silva, A.A.M., Departamento de Saúde Pública, Centro de Ciências Biológicas e da Saúde, Universidade Federal do Maranhão, Rua Barão de Itapary, 155, Centro, São Luís, MA CEP: 65020-070, Brazil",[No abstract available],,"COVID-19; Coronavirus infection; human; mortality; pandemic; virus pneumonia; Coronavirus Infections; Humans; Mortality; Pandemics; Pneumonia, Viral","(2020), https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6, Johns Hopkins University. Coronavirus COVID-19 Global Cases by Johns Hopkins CSSE [Internet]. Johns Hopkins University; (2020), https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19---3-march-2020, WHO Director-General’s opening remarks at the media briefing on COVID-19 – 3 March 2020 [Internet]. World Health Organization; The epidemiological char acteri sti cs of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China (2020) China CDC Wkly, 41 (2), pp. 145-151. , https://doi.org/10.3760/cma.j.issn.0254-6450.2020.02.003; https://www.who.int/docs/default-source/coronaviruse/who-china-joint-mission-on-covid-19-final-report.pdf, Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19) [Internet]. World Health Organization; 2020; https://apps.who.int/iris/bitstream/handle/10665/44123/9789241547680_eng.pdf, Pandemic Influenza preparedness and response: a WHO guidance document [Internet]. Geneva: World Health Organization; 2009 [cited on Mar. 6, 2020; Khandaker, G., Dierig, A., Rashid, H., King, C., Heron, L., Booy, R., Systematic review of clinical and epidemiological features of the pandemic influenza A (H1N1) 2009 (2011) Influenza Other Respir Viruses, 5 (3), pp. 148-156. , https://doi.org/10.1111/j.1750-2659.2011.00199.x; Fauci, A.S., Lane, H.C., Redfield, R.R., Covid-19 — Navigating the Uncharted (2020) N Engl J Med., , https://doi.org/10.1056/NEJMe2002387; Hellewell, J., Abbott, S., Gimma, A., Bosse, N.I., Jarvis, C.I., Russell, T.W., Feasibility of controlling COVID-19 outbreaks by isolation of cases and contacts (2020) Lancet Glob Health, , https://doi.org/10.1016/S2214-109X(20)30074-7, published online Feb 28; Guan, W.-J., Ni, Z.-Y., Hu, Y., Liang, W., Ou, C.-Q., He, J.-X., Clinical Characteristics of Coronavirus Disease 2019 in China N Engl J Med, , https://doi.org/10.1056/NEJMoa2002032; (2020), https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19---5-march-2020, WHO Director-General’s opening remarks at the media briefing on COVID-19-5 March 2020 [Internet]. World Health Organization; (2020), https://www.bbc.com/portuguese/brasil-51713943, BBC News Brasil. Ministério da Saúde confirma 9 casos do novo coronavírus no Brasil; já há transmissão local. BBC News Brasil [Internet]","da Silva, A.A.M.; Departamento de Saúde Pública, Centro de Ciências Biológicas e da Saúde, Universidade Federal do Maranhão, Rua Barão de Itapary, 155, Centro, Brazil; email: aamouradasilva@gmail.com",,"Assocaicao Brasileira de Pos, Gradacao em Saude Coletiva",1415790X,,,32187257,English,Rev. Bras. Epidemiol.,Editorial,Final,Open Access,Scopus,2-s2.0-85082013854,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Li L., Li Y., Lin M., Wang X., Bao P.",57215836091;57214959188;57215835741;57215835186;57215835438;,Preparing and responding to 2019 novel coronavirus with simulation and technology-enhanced learning for healthcare professionals: Challenges and opportunities in China,2020,BMJ Simulation and Technology Enhanced Learning,,, e2020000609,,,,,10.1136/bmjstel-2020-000609,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082001092&doi=10.1136%2fbmjstel-2020-000609&partnerID=40&md5=5c547682577e32b407bfeb9f5f8d0518,"Department of General Practice, Guangzhou First People's Hospital, South China University of Technology, Guangdong, Guangzhou, China; Department of Healthcare Simulation, Wu Jieping Medical Foundation, Beijing, China; Department of Nephrology, Second Xiangya Hospital of Central South University, Changsha, Hunan, China; Clinical Skills Training Center, Second Xiangya Hospital, Hunan, Changsha, China; Department of Emergency Medicine, Guangzhou First People's Hospital, Guangdong, Guangzhou, China; Department of Outpatient, Guangzhou First People's Hospital, Guangdong, Guangzhou, China","Li, L., Department of General Practice, Guangzhou First People's Hospital, South China University of Technology, Guangdong, Guangzhou, China, Department of Healthcare Simulation, Wu Jieping Medical Foundation, Beijing, China; Li, Y., Department of Nephrology, Second Xiangya Hospital of Central South University, Changsha, Hunan, China, Clinical Skills Training Center, Second Xiangya Hospital, Hunan, Changsha, China; Lin, M., Clinical Skills Training Center, Second Xiangya Hospital, Hunan, Changsha, China; Wang, X., Department of Healthcare Simulation, Wu Jieping Medical Foundation, Beijing, China, Department of Emergency Medicine, Guangzhou First People's Hospital, Guangdong, Guangzhou, China; Bao, P., Department of Outpatient, Guangzhou First People's Hospital, Guangdong, Guangzhou, China",[No abstract available],opportunities and challenges; simulation; technology enhanced learning,,"Hui, D.S., Azhar E, I., Madani, T.A., The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health - The latest 2019 novel coronavirus outbreak in Wuhan, China (2020) Int J Infect Dis, 91, pp. 264-266. , http://dx.doi.org/10.1016/j.ijid.2020.01.009; Lu, H., Stratton, C.W., Tang, Y.-W., Outbreak of pneumonia of unknown etiology in Wuhan, China: The mystery and the miracle (2020) J Med Virol, 92, pp. 401-402. , http://dx.doi.org/10.1002/jmv.25678; Novel Coronavirus (2019-nCoV): Situation Report - 20, , https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200209-sitrep-20-ncov.pdf?sfvrsn=6f80d1b9_4, World Health Organization, [Accessed 9 Feb 2020 ]; MOE Postpones Start of 2020 Spring Semester, , http://en.moe.gov.cn/news/press_releases/202001/t20200130_417069.html, Ministry of Education of the People's Republic of China; MOE Issues Instructions for Deployment of HEI Online Teaching, , http://en.moe.gov.cn/news/press_releases/202002/t20200208_419136.html, Ministry of Education of the People's Republic of China; Devereaux, A., Christian, M.D., Dichter, J.R., Summary of suggestions from the task force for mass critical care Summit, January 26-27, 2007 (2008) Chest, 133, pp. 1S-7. , http://dx.doi.org/10.1378/chest.08-0649; Rubinson, L., Hick, J.L., Hanfling, D.G., Definitive care for the critically ill during a disaster: A framework for optimizing critical care surge capacity: From a task force for mass critical care Summit meeting, January 26-27, 2007, Chicago, IL (2008) Chest, 133, pp. 18S-31. , http://dx.doi.org/10.1378/chest.07-2690; May, L., Shigyo, K., Stahmer, A., Pre-implementation assessment of an antimicrobial stewardship program for acute respiratory infections within emergency and urgent care settings (2017) Open Forum Infect Dis, 4, p. 261. , http://dx.doi.org/10.1093/ofid/ofx163.572; Han, C., Gao, S., Liu, H., Infectious diseases with five pre-triage and correlational research of nosocomial infection (2010) Chinese Journal of Nosocomiology, 20, pp. 3744-3745","Li, L.; General Practice, Guangzhou First People's HospitalChina; email: mrcatking@gmail.com",,BMJ Publishing Group,20566697,,,,English,BMJ Simul. Technol. Enhanc. Learning,Review,Article in Press,Open Access,Scopus,2-s2.0-85082001092,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Sahu K.K., Lal A., Mishra A.K.",56183820800;57200527565;50161911000;,An update on CT chest findings in coronavirus disease-19 (COVID-19),2020,Heart and Lung,,,,,,,,10.1016/j.hrtlng.2020.03.007,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081987950&doi=10.1016%2fj.hrtlng.2020.03.007&partnerID=40&md5=fc524b1c54124dcaadbe166cede0fb64,"Department of Medicine, Saint Vincent Hospital, Worcester, MA, United States; Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, United States","Sahu, K.K., Department of Medicine, Saint Vincent Hospital, Worcester, MA, United States; Lal, A., Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, United States; Mishra, A.K., Department of Medicine, Saint Vincent Hospital, Worcester, MA, United States",[No abstract available],,,"Sahu, K.K., Mishra, A.K., Lal, A., Comprehensive update on current outbreak of novel coronavirus infection (2019-nCoV) (2020) Ann Transl Med, , Ahead of Pub; Sahu, K.K., Mishra, A.K., Lal, A., Novel coronavirus (2019-nCoV): update on 3rd coronavirus outbreak of 21st century (2020) QJM, , 32125418 pii: hcaa081[Epub ahead of print] PubMed PMID:; Bernheim, A., Mei, X., Huang, M., Yang, Y., Fayad, Z.A., Zhang, N., Chest ct findings in coronavirus disease-19 (COVID-19): relationship to duration of infection. Radiology. 0(0):200463; Wu, J., Wu, X., Zeng, W., Chest ct findings in patients with corona virus disease 2019 and its relationship with clinical features (2020) Invest Radiol; Pan, Y., Guan, H., Zhou, S., Initial CT findings and temporal changes in patients with the novel coronavirus pneumonia (2019-nCoV): a study of 63 patients in Wuhan, China (2020) Eur Radiol; Mishra, A.K., Sahu, K.K., James, A., Disseminated herpes zoster following treatment with benralizumab (2019) Clin Respir J, 13 (3), pp. 189-191; Sahu, K.K., Prakash, G., Khadwal, A., Varma, S.C., Malhotra, P., A rare case of hemorrhagic cystitis in allogeneic hematopoietic stem cell transplant patient (2016) Indian J Hematol Blood Transfus, 32, pp. 196-200; Sahu, K.K., Mishra, A.K., Lal, A., Abraham, G.M., Mycobacterium Avium complex: a rare cause of pancytopenia in HIV infection (2020) J Microsc Ultrastruct, 8 (1), pp. 27-30","Sahu, K.K.; Department of Medicine, Saint Vincent HospitalUnited States; email: drkksahu85@gmail.com",,Mosby Inc.,1479563,,HELUA,,English,Heart Lung,Editorial,Article in Press,Open Access,Scopus,2-s2.0-85081987950,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Naicker S., Yang C.-W., Hwang S.-J., Liu B.-C., Chen J.-H., Jha V.",35564542600;57202512739;57202568674;57204739173;7501890906;7005119423;,The Novel Coronavirus 2019 epidemic and kidneys,2020,Kidney International,,,,,,,1,10.1016/j.kint.2020.03.001,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081968148&doi=10.1016%2fj.kint.2020.03.001&partnerID=40&md5=f1ba1a6a12e09d35253319b8e827e938,"Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Department of Nephrology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China; Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China; George Institute for Global Health India, UNSW, New Delhi, India; Manipal Academy of Higher Education, Manipal, India","Naicker, S., Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Yang, C.-W., Department of Nephrology, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Hwang, S.-J., Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Liu, B.-C., Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China; Chen, J.-H., Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China; Jha, V., George Institute for Global Health India, UNSW, New Delhi, India, Manipal Academy of Higher Education, Manipal, India",[No abstract available],acute kidney injury; hemodialysis,,"Wang, D., Hu, B., Hu, C., (2020), Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. Accessed March 2; Coronavirus disease (COVID-2019) situation reports https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports, Available at: (Accessed 16 March 2020); Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19) https://www.who.int/docs/default-source/coronaviruse/who-china-joint-mission-on-covid-19-final-report.pdf, Available at: (Accessed 2 March 2020); Summary of probable SARS cases with onset of illness from 1 November 2002 to 31 July 2003 https://www.who.int/csr/sars/country/table2004_04_21/en/, Available at: (Accessed 27 January 2020); Middle East respiratory syndrome coronavirus (MERS-CoV). November 2019 http://www.who.int/emergencies/mers-cov/en/, Available at: (Accessed 27 February 2020); Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) The Lancet, 395, pp. 497-506; Frequently asked questions and answers: Coronavirus Disease-2019 (COVID-19) and children https://www.cdc.gov/coronavirus/2019-ncov/specific-groups/children-faq.html, Available at: (Accessed 2 March 2020); Ling, L., Taisheng, L., The National Health Commission of PRC Guideline for diagnosis and treatment of novel coronavirus disease (version 6) (2020) Natl Med J China, 100, p. E001; Specimen referral for 2019nCoV - operational details of referral laboratories https://www.who.int/docs/default-source/coronaviruse/who-appointed-2019-ncov-referral-laboratories-7-february-2020.pdf?sfvrsn=c3fa3ec3_4, Available at: (Accessed 2 March 2020); Normile, D., Singapore claims first use of antibody test to track coronavirus infections https://www.sciencemag.org/news/2020/02/singapore-claims-first-use-antibody-test-track-coronavirus-infections, Available at: (Accessed 2 March 2020); Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395, pp. 507-513; Guan, W.J., Ni, Z.Y., Hu, Y., (2020), Clinical characteristics of 2019 novel coronavirus infection in China [e-pub ahead of print]. N Engl J Med. Accessed March 2; Cheng, Y., Luo, R., Wang, K., (2020), Kidney impairment is associated with in-hospital death of COVID-19 patients [e-pub ahead of print]. medRxiv 2020.02.18.20023242. Accessed March 2; Li, Z., Wu, M., Guo, J., Caution on kidney dysfunctions of 2019-nCoV patients. medRxiv 2020.02.08.20021212 (Accessed 2 March 2020); Li, W., Moore, M.J., Vasilieva, N., Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus (2003) Nature, 426, pp. 450-454; Raj, V.S., Mou, H., Smits, S.L., Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC (2013) Nature, 495, pp. 251-254; Peiri, J.S.M., Chu, C.M., Cheng, V.C.C., Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study (2003) Lancet, 361, pp. 1767-1772; Ding, Y., He, L., Zhang, Q., Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways (2004) J Pathol, 203, pp. 622-630; The team of Zhong Nanshan responded that the isolation of SARS-CoV-2 from urine remind us to pay more attention to the cleaning of individuals and families (2020) Guangzhou Daily; Expert consensus on diagnosis and treatment of 2019 novel coronavirus (2019 - nCoV) infection with acute kidney injury (2020) Chin J Nephrol, 3; Gao, J., Tian, Z., Yang, X., Breakthrough: chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies (2020) Biosci Trends, 14, pp. 72-73; Chu, K.H., Tsang, W.K., Tang, C.S., Acute renal impairment in coronavirus-associated severe acute respiratory syndrome (2005) Kidney Int, 67, pp. 698-705; Arabi, Y.M., Arifi, A.A., Balkhy, H.H., Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection (2014) Ann Intern Med, 160, pp. 389-397; Ghani, R.A., Zainudin, S., Ctkong, N., Serum IL-6 and IL-1-ra with sequential organ failure assessment scores in septic patients receiving high-volume haemofiltration and continuous venovenous haemofiltration (2006) Nephrology (Carlton), 11, pp. 386-393; Chen, R.C., Tang, X.P., Tan, S.Y., Treatment of severe acute respiratory syndrome with glucosteroids: the Guangzhou experience (2006) Chest, 129, pp. 1441-1452; Arabi, Y.M., Mandourah, Y., Al-Hameed, F., Corticosteroid therapy for critically ill patients with middle east respiratory syndrome (2018) Am J Respir Crit Care Med, 197, pp. 757-767; Stockman, L.J., Bellamy, R., Garner, P., SARS: systematic review of treatment effects (2006) PLoS Med, 3, p. e343; Russell, C.D., Millar, J.E., Baillie, J.K., Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury (2020) Lancet, 395, pp. 473-475; Park, B.K., Maharjan, S., Lee, S.I., Generation and characterization of a monoclonal antibody against MERS-CoV targeting the spike protein using a synthetic peptide epitope-CpG-DNA-liposome complex (2019) BMB Rep, 52, pp. 397-402; Ma, Y., Diao, B., Lv, X., 2019 novel coronavirus disease in hemodialysis (HD) patients: report from one HD center in Wuhan, China https://www.medrxiv.org/content/10.1101/2020.02.24.20027201v2, Available at: (Accessed 2 March 2020); Recommendations for prevention and control of novel coronavirus infection in blood purification center (room) from Chinese Medical Association Nephrology Branch (2020) Chin J Nephrol, 36, pp. 82-84; Hwang, S.-J., Guideline for dialysis facilities during COVID-19 outbreak. Taiwan Society of Nephrology https://tinyurl.com/yx3zc5up, Available at: (Accessed 16 March 2020)","Jha, V.; The George Institute for Global Health, Jasola District Centre, 310-11 Elegance Tower, India; email: vjha@georgeinstitute.org.in",,Elsevier B.V.,852538,,KDYIA,,English,Kidney Int.,Editorial,Article in Press,Open Access,Scopus,2-s2.0-85081968148,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Lin S.-M., Lin S.-C., Hsu J.-N., Chang C.-K., Chien C.-M., Wang Y.-S., Wu H.-Y., Jeng U.-S., Kehn-Hall K., Hou M.-H.",57215823849;57192909217;57215818049;57215816208;57215810727;56770204800;57215816260;57142087700;35553615900;7201437352;,Structure-Based Stabilization of Non-native Protein-Protein Interactions of Coronavirus Nucleocapsid Proteins in Antiviral Drug Design,2020,Journal of Medicinal Chemistry,63,6,,3131,3141,,,10.1021/acs.jmedchem.9b01913,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081967447&doi=10.1021%2facs.jmedchem.9b01913&partnerID=40&md5=05023ed70173b259f29c47b60c6e0b1d,"Institute of Genomics and Bioinformatics, Department of Life Sciences, National Chung Hsing University, Taichung, 402, Taiwan; National Center for Biodefense and Infectious Diseases, School of Systems Biology, George Mason University, Manassas, VA 20110, United States; Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan; Graduate Institute of Veterinary Pathobiology, College of Veterinary Medicine, National Chung Hsing University, Taichung, 40227, Taiwan; National Synchrotron Radiation Research Center, Hsinchu, 30076, Taiwan; Department of Chemical Engineering, National Tsing Hua University, Hsinchu, 30013, Taiwan","Lin, S.-M., Institute of Genomics and Bioinformatics, Department of Life Sciences, National Chung Hsing University, Taichung, 402, Taiwan; Lin, S.-C., National Center for Biodefense and Infectious Diseases, School of Systems Biology, George Mason University, Manassas, VA 20110, United States; Hsu, J.-N., Institute of Genomics and Bioinformatics, Department of Life Sciences, National Chung Hsing University, Taichung, 402, Taiwan; Chang, C.-K., Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan; Chien, C.-M., Institute of Genomics and Bioinformatics, Department of Life Sciences, National Chung Hsing University, Taichung, 402, Taiwan; Wang, Y.-S., Institute of Genomics and Bioinformatics, Department of Life Sciences, National Chung Hsing University, Taichung, 402, Taiwan; Wu, H.-Y., Graduate Institute of Veterinary Pathobiology, College of Veterinary Medicine, National Chung Hsing University, Taichung, 40227, Taiwan; Jeng, U.-S., National Synchrotron Radiation Research Center, Hsinchu, 30076, Taiwan, Department of Chemical Engineering, National Tsing Hua University, Hsinchu, 30013, Taiwan; Kehn-Hall, K., National Center for Biodefense and Infectious Diseases, School of Systems Biology, George Mason University, Manassas, VA 20110, United States; Hou, M.-H., Institute of Genomics and Bioinformatics, Department of Life Sciences, National Chung Hsing University, Taichung, 402, Taiwan","Structure-based stabilization of protein-protein interactions (PPIs) is a promising strategy for drug discovery. However, this approach has mainly focused on the stabilization of native PPIs, and non-native PPIs have received little consideration. Here, we identified a non-native interaction interface on the three-dimensional dimeric structure of the N-terminal domain of the MERS-CoV nucleocapsid protein (MERS-CoV N-NTD). The interface formed a conserved hydrophobic cavity suitable for targeted drug screening. By considering the hydrophobic complementarity during the virtual screening step, we identified 5-benzyloxygramine as a new N protein PPI orthosteric stabilizer that exhibits both antiviral and N-NTD protein-stabilizing activities. X-ray crystallography and small-angle X-ray scattering showed that 5-benzyloxygramine stabilizes the N-NTD dimers through simultaneous hydrophobic interactions with both partners, resulting in abnormal N protein oligomerization that was further confirmed in the cell. This unique approach based on the identification and stabilization of non-native PPIs of N protein could be applied toward drug discovery against CoV diseases. © 2020 American Chemical Society. All rights reserved.",,,,"Hou, M.-H.; Institute of Genomics and Bioinformatics, Department of Life Sciences, National Chung Hsing UniversityTaiwan; email: mhho@nchu.edu.tw",,American Chemical Society,222623,,JMCMA,32105468,English,J. Med. Chem.,Article,Final,Open Access,Scopus,2-s2.0-85081967447,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Bearman G., Pryor R., Albert H., Brath L., Britton A., Cooper K., Doll M., Godbout E.J., Hemphill R., Stevens M.P.",6701806032;57194473797;57205099138;6506830452;57215812072;57192999311;56763769700;57191615504;7005959952;7402243145;,Novel Coronavirus and Hospital Infection Prevention: Preparing for the Impromptu Speech,2020,Infection Control and Hospital Epidemiology,,,,,,,,10.1017/ice.2020.55,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081966091&doi=10.1017%2fice.2020.55&partnerID=40&md5=c79e73fb7ddd949c588de801ba0e8a98,"Healthcare Infection Prevention Department, Virginia Commonwealth University Health System, North Hospital, 1300 E. Marshall St., Box 980019, Richmond, VA 23298, United States; Department of Medicine, Virginia Commonwealth University Health System, Richmond, VA, United States; Department of Pediatrics, Division of Pediatric Infectious Diseases, Children's Hospital of Richmond, Virginia Commonwealth University, Richmond, VA, United States","Bearman, G., Healthcare Infection Prevention Department, Virginia Commonwealth University Health System, North Hospital, 1300 E. Marshall St., Box 980019, Richmond, VA 23298, United States; Pryor, R., Healthcare Infection Prevention Department, Virginia Commonwealth University Health System, North Hospital, 1300 E. Marshall St., Box 980019, Richmond, VA 23298, United States; Albert, H., Healthcare Infection Prevention Department, Virginia Commonwealth University Health System, North Hospital, 1300 E. Marshall St., Box 980019, Richmond, VA 23298, United States; Brath, L., Department of Medicine, Virginia Commonwealth University Health System, Richmond, VA, United States; Britton, A., Healthcare Infection Prevention Department, Virginia Commonwealth University Health System, North Hospital, 1300 E. Marshall St., Box 980019, Richmond, VA 23298, United States; Cooper, K., Healthcare Infection Prevention Department, Virginia Commonwealth University Health System, North Hospital, 1300 E. Marshall St., Box 980019, Richmond, VA 23298, United States; Doll, M., Healthcare Infection Prevention Department, Virginia Commonwealth University Health System, North Hospital, 1300 E. Marshall St., Box 980019, Richmond, VA 23298, United States; Godbout, E.J., Department of Pediatrics, Division of Pediatric Infectious Diseases, Children's Hospital of Richmond, Virginia Commonwealth University, Richmond, VA, United States; Hemphill, R., Healthcare Infection Prevention Department, Virginia Commonwealth University Health System, North Hospital, 1300 E. Marshall St., Box 980019, Richmond, VA 23298, United States; Stevens, M.P., Healthcare Infection Prevention Department, Virginia Commonwealth University Health System, North Hospital, 1300 E. Marshall St., Box 980019, Richmond, VA 23298, United States",[No abstract available],,,"Infection Prevention and Control during Health Care When Novel Coronavirus (NCoV) Infection Is Suspected, Interim Guidance, , http://www.who.int/publications-detail/infection-prevention-and-control-during-health-care-when-novel-coronavirus-(ncov)-infection-is-suspected-20200125, World Health Organization, Updated Jan 25th 2020. Accessed Feb 5th 2020; Interim Infection Prevention and Control Recommendations for Patient with Confirmed 2019 Novel Coronavirus (2019-nCoV) or Patients under Investigation for 2019-nCoV in Healthcare Settings, , http://www.cdc.gov/coronavirus/2019-nCoV/hcp/infection-control.html, Centers for Disease Control and Prevention, Updated Feb 3rd 2020. Accessed Feb 5th 2020; Osei-Bonsu, K., Masroor, N., Cooper, K., Doern, C., Jefferson, K., Major, Y., Alternative doffing strategies of personal protective equipment to prevent self-contamination in the health care setting (2019) Am J Infect Control, 47 (5), pp. 534-539. , May; Bearman, G.M., Vokes, R.A., Averting a betrayal of trust: System and individual accountability in healthcare infection prevention (2019) Infect Control Hosp Epidemiol, 40 (8), pp. 918-919","Pryor, R.; Healthcare Infection Prevention Department, Virginia Commonwealth University Health System, North Hospital, 1300 E. Marshall St., Box 980019, United States",,Cambridge University Press,0899823X,,ICEPE,32122422,English,Infect. Control Hosp. Epidemiol.,Article,Article in Press,Open Access,Scopus,2-s2.0-85081966091,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Hong H., Wang Y., Chung H.-T., Chen C.-J.",57215817649;57215822550;7404006712;57215816773;,"Clinical characteristics of novel coronavirus disease 2019 (COVID-19) in newborns, infants and children",2020,Pediatrics and Neonatology,,,,,,,,10.1016/j.pedneo.2020.03.001,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081947441&doi=10.1016%2fj.pedneo.2020.03.001&partnerID=40&md5=02fbb9d2b266dd970b611b7a6fb310d8,"Department of Pediatrics, Xiamen Chang Gung Hospital, Xiamen, Fujian, China; Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan","Hong, H., Department of Pediatrics, Xiamen Chang Gung Hospital, Xiamen, Fujian, China; Wang, Y., Department of Pediatrics, Xiamen Chang Gung Hospital, Xiamen, Fujian, China; Chung, H.-T., Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan; Chen, C.-J., Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan",[No abstract available],,,"Hui, D.S., I Azhar, E., Madani, T.A., Ntoumi, F., Kock, R., Dar, O., The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health — the latest 2019 novel coronavirus outbreak in Wuhan, China (2020) Int J Infect Dis, 91, pp. 264-266; Dong, E., Du, H., Gardner, L., An interactive web-based dashboard to track COVID-19 in real time (2020) Lancet Infect Dis; Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med, , https://www.nejm.org/doi/10.1056/NEJMoa2001316; Munster, V.J., Koopmans, M., van Doremalen, N., van Riel, D., de Wit, E., A novel coronavirus emerging in China — key questions for impact assessment (2020) N Engl J Med, 382, pp. 692-694; Zhu, H., Wang, L., Fang, C., Peng, S., Zhang, L., Chang, G., Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia (2020) Transl Pediatr, 9, pp. 51-60; Guan, W.J., Ni, Z.Y., Hu, Y., Liang, W.H., Ou, C.Q., He, J.X., Clinical characteristics of 2019 novel coronavirus infection in China (2020) MedRxiv; Chan, J.F., Yuan, S., Kok, K.H., To, K.K., Chu, H., Yang, J., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, 395, pp. 514-523; Chen, F., Liu, Z.S., Zhang, F.R., Xiong, R.H., Chen, Y., Cheng, X.F., Frist case of severe childhood novel coronavirus pneumonia in China (2020) Zhonghua Er Ke Za Zhi, 58, p. E005. , [Article in Chinese]; Wei, M., Yuan, J., Liu, Y., Fu, T., Yu, X., Zhang, Z.J., Novel coronavirus infection in hospitalized infants under 1 year of age in China (2020) JAMA; Chen, C., Guo, J., Wang, C., Luo, F., Yu, X., Zhang, W., Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records (2020) Lancet, 395, pp. 809-815; Wang, J., Qi, H., Bao, L., Li, F., Shi, Y., A contingency plan for the management of the 2019 novel coronavirus outbreak in neonatal intensive care units (2020) Lancet Child Adolesc Health","Wang, Y.; Department of Pediatrics, Xiamen Chang Gung Hospital, No. 123, Sha-Fei Road, Haicang, China; email: wangyuan@adm.cgmh.com.cn",,Elsevier (Singapore) Pte Ltd,18759572,,,,English,Pediatr. Neonatol.,Short Survey,Article in Press,Open Access,Scopus,2-s2.0-85081947441,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wang Y., Zhu L.-Q.",57215782170;36116282300;,Pharmaceutical care recommendations for antiviral treatments in children with coronavirus disease 2019,2020,World Journal of Pediatrics,,,,,,,,10.1007/s12519-020-00353-5,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081932813&doi=10.1007%2fs12519-020-00353-5&partnerID=40&md5=77663f1cce2ff23941e0d1e71d4adf73,"Department of Pharmacy, Tianjin Children’s Hospital, Tianjin, 300134, China; Department of Pharmacy, Tianjin First Central Hospital, Tianjin, 300192, China","Wang, Y., Department of Pharmacy, Tianjin Children’s Hospital, Tianjin, 300134, China; Zhu, L.-Q., Department of Pharmacy, Tianjin First Central Hospital, Tianjin, 300192, China",[No abstract available],,,"(2020) Notice on Printing and Distributing the Diagnosis and Treatment Plan of COVID-19 (Trial Version 6, , https://www.nhc.gov.cn/yzygj/s7653p/202002/8334a8326dd94d329df351d7da8aefc2.shtml, Accessed 19 Feb; Falzarano, D., de Wit, E., Rasmussen, A.L., Feldmann, F., Okumura, A., Scott, D.P., Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques (2013) Nat Med, 19, pp. 1313-1317. , COI: 1:CAS:528:DC%2BC3sXhtl2ktr3J; Shang, X.Y., Huang, Y., Liu, E.M., Chen, Q., Cao, L., Lu, M., A multicenter clinical study on the treatment for children's acute bronchiolitis by nebulized recombinant human interferon α1b (2014) Chin J Pract Pediatr, 29, pp. 840-844. , (in Chinese; Cui, L.D., Jin, Z.P., Wang, Q., Cheng, Y.B., Wang, Q.S., The effect of recombinant human interferon α1b combined with human normal immunoglobulin on serum cytokine and immunoglobulins levels in bronchiolitis children (2018) Chin J Hosp Pharm., 38, pp. 403-406. , (in Chinese; Zhong, Q.L., Zheng, Y.W., Yan, J.J., Deng, Y.F., Tang, L., Cui, Z.L., The contrast observation of the clinical efficacy and safety of interferon nebulization and ribavirin in the treatment of infantile herpes angina (2017) Chin Med Pharm, 7, pp. 80-82. , (in Chinese; Lin, Y., Hu, Y.Y., Lin, Z., Evaluation of efficacy and safety of interferon α2b spray for children with herpetic angina (2017) J Pediatr Pharm, 23, pp. 9-12. , (in Chinese; Lai, C.Z., Comparison of the efficacy of nebulized inhaled interferon and intramuscular injection of interferon in the treatment of hand, foot and mouth disease (2014) Chin J Clin Ratio Drug Use, 7, pp. 49-50. , (in Chinese; Lin, H., Huang, L., Zhou, J., Lin, K., Wang, H., Xue, X., Efficacy and safety of interferon-α2b spray in the treatment of hand, foot, and mouth disease: a multicenter, randomized, double blind trial (2016) Arch Virol, 161, pp. 3073-3080. , COI: 1:CAS:528:DC%2BC28XhtlCru7vP; Shen, K.L., Yang, Y., Wang, T., Zhao, D., Jiang, Y., Jin, R., Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts' consensus statement (2020) World J Pediatr; Shen, K.L., Shang, Y.X., Zhang, G.C., Xu, B.P., Fu, Z., Cao, L., Expert consensus on reasonable application of interferon in pediatrics (2018) Chin J Appl Clin Pediatr, 33, pp. 1301-1308. , (in Chinese; Zhang, G.C., Shang, Y.X., Expert consensus on clinical application of recombinant human interferon α1b in pediatrics (2015) Chin J Appl Clin Pediatr, 30, pp. 1220-1222. , (in Chinese; Interferon α-2b Injection, , https://drugs.dxy.cn/drug/153953/detail.htm#14, Accessed 11 Feb 2020; Chan, K.S., Lai, S.T., Chu, C.M., Tsui, E., Tam, C.Y., Wong, M.M., Treatment of severe acute respiratory syndrome with lopinavir/ritonavir: a multicentre retrospective matched cohort study (2003) Hong Kong Med J, 9, pp. 399-406. , COI: 1:STN:280:DC%2BD3srpsFKhuw%3D%3D, PID: 14660806; Chong, Y.P., Song, J.Y., Seo, Y.B., Choi, J.P., Shin, H.S., Antiviral treatment guidelines for Middle East respiratory syndrome (2015) Infect Chemother., 47, pp. 212-222; Lopinavir–ritonavir Solution, , https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4b1caefa-e6a2-42f3-9194-6dc1dd9e6d85, Accessed 12 Feb 2020; Lopinavir/Ritonavir Oral Solution, , https://drugs.dxy.cn/drug/58394/detail.htm#4, Accessed 24 Feb 2020; Chen, Z.M., Fu, J.F., Shu, Q., Wang, W., Chen, Y.H., Hua, C.Z., Diagnosis and treatment recommendation for pediatric coronavirus disease-19 (the second edition) (2020) J ZheJiang Univ (Med Sci), , (in Chinese; Kaletra-Lopinavir and Ritonavir Tablet, Film Coated, , https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3fa34341-1dce-4bad-b97e-f466e96a0bbe, DailyMed, Accessed 1 Feb 2020; Lopinavir and Ritonavir, , https://www.uptodate.com/contents/lopinavir-and-ritonavir-drug-information?search=lopinavir&source=search_result&selectedTitle=1~61&usage_type=default&display_rank=1, Accessed 6 Feb 2020; Rebetol-Ribavirin Capsule/Liquid, , https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=04d2b6f4-bd9b-4871-9527-92c81aa2d4d0, Accessed 11 Feb 2020; De Franceschi, L., Fattovich, G., Turrini, F., Ayi, K., Brugnara, C., Manzato, F., Hemolytic anemia-induced by ribavirin therapy in patients with chronic hepatitis C virus infection: role of membrane oxidative damage (2000) Hepatology, 31, pp. 997-1004; Rao, Y.H., Ribavirin-induced adverse drug reactions (ADRs): literature review of 182 cases (2007) Eva Ana Drug Use Hosp Chin, 4, pp. 52-56. , (in Chinese; Gao, J., Tian, Z., Yang, X., Breakthrough: chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies (2020) Biosci Trends, , (Epub ahead of print; (2020) . Notice on Printing and Distributing the Adjustment of Dosage Regimen of Chloroquine Diphosphate in COVID-19, , https://www.nhc.gov.cn/yzygj/s7653p/202002/0293d017621941f6b2a4890035243730.shtml.Accessed, 28 Feb; Riou, B., Barriot, P., Rimailho, A., Baud, F.J., Treatment of severe chloroquine poisoning (1988) N Engl J Med, 318, pp. 1-6. , COI: 1:STN:280:DyaL1c%2FpsVGgtw%3D%3D; Expert consensus on chloroquine phosphate for the treatment of novel coronavirus pneumonia (2020) Chin J Tubere Respir Dis., 43, p. E019. , (in Chinese; Haviernik, J., Štefánik, M., Fojtíková, M., Arbidol (umifenovir): a broad-spectrum antiviral drug that inhibits medically important arthropod-borne flaviviruses (2018) Viruses, 10, p. E184; Lu, H., Drug treatment options for the 2019-new coronavirus (2019-nCoV) (2020) Biosci Trends, , (Epub ahead of print; Zhang, J., Fang, F., Research progress of non-nucleoside antiviral drug Arbidol (2011) Chin J Evid Based Pediatr, 6, pp. 308-312. , (in Chinese","Zhu, L.-Q.; Department of Pharmacy, Tianjin First Central HospitalChina; email: zlq0713@aliyun.com",,Institute of Pediatrics of Zhejiang University,17088569,,,32166483,English,World J. Pediatr.,Article,Article in Press,Open Access,Scopus,2-s2.0-85081932813,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Montero Feijoo A., Maseda E., Adalia Bartolomé R., Aguilar G., González de Castro R., Gómez-Herreras J.I., García Palenciano C., Pereira J., Ramasco Rueda F., Samso E., Suárez de la Rica A., Tamayo Medel G., Varela Durán M., en nombre del Grupo de Trabajo de Infeccion Perioperatoria de la Sociedad Espanola de Anestesiologia y Reanimacion (GTIPO-SEDAR)",57201614160;6603190773;57215769546;7005523676;7801607898;6601932970;7801361983;57214155891;6506661805;6602397600;56043932500;36631082900;56298817700;,Practical recommendations for the perioperative management of the patient with suspection or serious infection by coronavirus SARS-CoV [Recomendaciones prácticas para el manejo perioperatorio del paciente con sospecha o infección grave por coronavirus SARS-CoV-2],2020,Revista Espanola de Anestesiologia y Reanimacion,,,,,,,,10.1016/j.redar.2020.03.003,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081924823&doi=10.1016%2fj.redar.2020.03.003&partnerID=40&md5=6de68ff6d6405369f1438237811e4021,"Unidad de Cuidados Críticos Quirúrgicos, Servicio de Anestesia, Hospital Universitario La Paz; Unidad de Reanimación Quirúrgica, Servicio de Anestesiología y Reanimación, Hospital del Mar; Unidad de Cuidados Críticos, Servicio de Anestesiología, Reanimación y Terapéutica del Dolor, Hospital Clínico Universitario de Valencia; Unidad de Reanimación, Servicio de Anestesiología y Reanimación, Hospital Universitario de León; Servicio de Anestesiología y Reanimación, Hospital Clínico Universitario de Valladolid; Servicio de Anestesia y Reanimación, Hospital Clínico Universitario Virgen de la Arrixaca; Servicio de Anestesiología y Reanimación, Hospital Universitario Álvaro Cunqueiro; Unidad de Reanimación, Servicio de Anestesiología y Reanimación, Hospital Universitario de La Princesa; Unidad de Reanimación, Servicio de Anestesiología y Reanimación, Hospital Universitario Cruces; Servicio de Anestesiología y Reanimación, Complejo Hospitalario Universitario de Pontevedra","Montero Feijoo, A., Unidad de Cuidados Críticos Quirúrgicos, Servicio de Anestesia, Hospital Universitario La Paz; Maseda, E., Unidad de Cuidados Críticos Quirúrgicos, Servicio de Anestesia, Hospital Universitario La Paz; Adalia Bartolomé, R., Unidad de Reanimación Quirúrgica, Servicio de Anestesiología y Reanimación, Hospital del Mar; Aguilar, G., Unidad de Cuidados Críticos, Servicio de Anestesiología, Reanimación y Terapéutica del Dolor, Hospital Clínico Universitario de Valencia; González de Castro, R., Unidad de Reanimación, Servicio de Anestesiología y Reanimación, Hospital Universitario de León; Gómez-Herreras, J.I., Servicio de Anestesiología y Reanimación, Hospital Clínico Universitario de Valladolid; García Palenciano, C., Servicio de Anestesia y Reanimación, Hospital Clínico Universitario Virgen de la Arrixaca; Pereira, J., Servicio de Anestesiología y Reanimación, Hospital Universitario Álvaro Cunqueiro; Ramasco Rueda, F., Unidad de Reanimación, Servicio de Anestesiología y Reanimación, Hospital Universitario de La Princesa; Samso, E., Unidad de Reanimación Quirúrgica, Servicio de Anestesiología y Reanimación, Hospital del Mar; Suárez de la Rica, A., Unidad de Cuidados Críticos Quirúrgicos, Servicio de Anestesia, Hospital Universitario La Paz; Tamayo Medel, G., Unidad de Reanimación, Servicio de Anestesiología y Reanimación, Hospital Universitario Cruces; Varela Durán, M., Servicio de Anestesiología y Reanimación, Complejo Hospitalario Universitario de Pontevedra; en nombre del Grupo de Trabajo de Infeccion Perioperatoria de la Sociedad Espanola de Anestesiologia y Reanimacion (GTIPO-SEDAR)","In December 2019, the Wuhan Municipal Health and health Commission (Hubei Province, China) reported a series of cases of pneumonia of unknown etiology. On January 7, 2020, the Chinese authorities identified as a causative agent of the outbreak a new type of virus of the Coronaviridiae family, called SARS-CoV-2. Since then, thounsands of cases have been reported with global dissemination. Infections in humans cause a broad clinical spectrum ranging from mild upper respiratory tract infection, to severe acute respiratory distress syndrome and sepsis. There is not specific treatment for SARS-CoV-2, which is why the fundamental aspects are to establish adequate prevention measures and support treatment and management of complications. © 2020 Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor",Infection; Operating room; Recommendation; Virus,,"Wang, C., Horby, P.W., Hayden, F.G., Gao, G.F., A novel coronavirus outbreak of global health concern (2020) Lancet, 395, pp. 470-473; Wu, Z., McGoogan, J.M., Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention (2020) JAMA; Yang, X., Yu, Y., Xu, J., Shu, H., Xia, J., Liu, H., Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan China: a single-centered, retrospective, observational study (2020) Lancet Respir Med., piiS2213–2600, pp. 30079-30085; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506; Chan, J.F., Yuan, S., Kok, K.H., To, K.K., Chu, H., Yang, J., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, 395, pp. 514-523; Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan China: A descriptive study (2020) Lancet, 395, pp. 507-513; Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) JAMA; Chang, Lin, M., Wei, L., Xie, L., Zhu, G., Dela Cruz, C.S., Epidemiologic and clinical characteristics of novel coronavirus infections involving 13 patients outside Wuhan, China (2020) JAMA; Yang, X., Yu, Y., Xu, J., Shu, H., Xia, J., Liu, H., Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan China:A single-centered, retrospective, observational study (2020) Lancet Respir Med, piiS2213–2600, pp. 30079-30085; Bai, Y., Yao, L., Wei, T., Tian, F., Jin, D.Y., Chen, L., Presumed asymptomatic carrier transmission of COVID-19 (2020) JAMA; Arabi, Y.M., Fowler, R., Hayden, F.G., Critical care management of adults with communityacquired severe respiratory viral infection (2020) Intensive Care Med, 46, pp. 315-328; Hui, D.S.C., Zumla, A., Severe acute respiratory syndrome: Historical epidemiologic, and clinical features (2019) Infect Dis Clin North Am, 33, pp. 869-889; Qiu, H., Tong, Z., Ma, P., Hu, M., Peng, Z., Wu, W., Intensive care during the coronavirus epidemic (2020) Intensive Care Med; MacLaren, G., Fisher, D., Brodie, D., Preparing for the most critically ill patients with COVID-19: The potential role of extracorporeal membrane oxygenation (2020) JAMA; Ronco, C., Navalesi, P., Vincent, J.L., Coronavirus epidemic: Preparing for extracorporeal organ support in intensive care (2020) Lancet Respir Med, piiS2213–2600, pp. 30060-30066; Russell, C.D., Millar, J.E., Baillie, J.K., Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury (2020) Lancet, 395, pp. 473-475; Liao, X., Wang, B., Kang, Y., Novel coronavirus infection during the 2019-2020 epidemic: Preparing intensive care units-the experience in Sichuan Province, China (2020) Intensive Care Med, 46, pp. 357-360; Wax, R.S., Christian, M.D., Practical recommendations for critical care and anesthesiology teams caring for novel coronavirus (2019-nCoV) patients (2020) Can J Anaesth; Bouadma, L., Lescure, F.X., Lucet, J.C., Yazdanpanah, Y., Timsit, J.F., Severe SARS-CoV-2 infections: Practical considerations and management strategy for intensivists (2020) Intensive Care Med","Maseda, E.; Unidad de Cuidados Críticos Quirúrgicos, Servicio de Anestesia, Hospital Universitario La Pazemail: emilio.maseda@gmail.com",,Elsevier Doyma,349356,,REANB,,English; Spanish,Rev. Esp. Anestesiol. Reanim.,Article,Article in Press,Open Access,Scopus,2-s2.0-85081924823,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Huang P., Liu T., Huang L., Liu H., Lei M., Xu W., Hu X., Chen J., Liu B.",57215864488;57215865946;57215867256;57215867637;57194897791;57194900482;57215866079;57215865021;55574234266;,Use of chest CT in combination with negative RT-PCR assay for the 2019 novel coronavirus but high clinical suspicion,2020,Radiology,295,1,,22,23,,2,10.1148/radiol.2020200330,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081924197&doi=10.1148%2fradiol.2020200330&partnerID=40&md5=d6d0b4c77d27a2ab9dae1ef5b2936558,"Department of Radiology, Guangdong Hospital of Traditional Chinese Medicine, Zhuhai, 519000, China; Department of Radiology, Guangdong Hospital of Traditional Chinese Medicine, No. 111 Dade Rd, Guangzhou, 510000, China","Huang, P., Department of Radiology, Guangdong Hospital of Traditional Chinese Medicine, Zhuhai, 519000, China; Liu, T., Department of Radiology, Guangdong Hospital of Traditional Chinese Medicine, Zhuhai, 519000, China; Huang, L., Department of Radiology, Guangdong Hospital of Traditional Chinese Medicine, Zhuhai, 519000, China; Liu, H., Department of Radiology, Guangdong Hospital of Traditional Chinese Medicine, Zhuhai, 519000, China; Lei, M., Department of Radiology, Guangdong Hospital of Traditional Chinese Medicine, Zhuhai, 519000, China; Xu, W., Department of Radiology, Guangdong Hospital of Traditional Chinese Medicine, Zhuhai, 519000, China; Hu, X., Department of Radiology, Guangdong Hospital of Traditional Chinese Medicine, Zhuhai, 519000, China; Chen, J., Department of Radiology, Guangdong Hospital of Traditional Chinese Medicine, Zhuhai, 519000, China; Liu, B., Department of Radiology, Guangdong Hospital of Traditional Chinese Medicine, No. 111 Dade Rd, Guangzhou, 510000, China",[No abstract available],,adult; case report; Chinese; clinical article; computer assisted tomography; coronavirus disease 2019; Coronavirus infection; false negative result; fatigue; fever; fluorescence quantitative polymerase chain reaction; ground glass opacity; human; male; Note; priority journal; radiological parameters; sore throat,"Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., Zhao, X., Tan, W., A novel coronavirus from patients with pneumonia in China, 2019 N Engl J Med, , Published online January 24, 2020; Fact Sheet for Healthcare Providers: CDC - 2019-nCoV Real-Time RT-PCRDiagnosticPanel, , https://www.fda.gov/media/134920/download, Published February 4, 2020. Accessed February 6, 2020; Song, F., Shi, N., Shan, F., Emerging coronavirus 2019-NCoV pneumonia Radiology, 2020. , https://doi.org/10.1148/radiol.2020200274, Published online February 6, 2020","Liu, B.; Department of Radiology, Guangdong Hospital of Traditional Chinese Medicine, No. 111 Dade Rd, China; email: liubogzcm@163.com",,Radiological Society of North America Inc.,338419,,RADLA,32049600,English,Radiology,Note,Final,Open Access,Scopus,2-s2.0-85081924197,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Dosa D., Jump R.L.P., LaPlante K., Gravenstein S.",9234551700;15052074500;57211258719;7003966799;,Long-Term Care Facilities and the Coronavirus Epidemic: Practical Guidelines for a Population at Highest Risk,2020,Journal of the American Medical Directors Association,,,,,,,,10.1016/j.jamda.2020.03.004,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081911095&doi=10.1016%2fj.jamda.2020.03.004&partnerID=40&md5=cd1359826deb9d1e0078c567e0e7d91d,"Warren Alpert School of Medicine, Brown University, Providence, RI, United States; School of Public Health, Brown University, Providence, RI, United States; Providence VAMC Center of Innovation (COIN), Providence, RI, United States; Geriatric Research Education and Clinical Center (GRECC) at the VA Northeast Ohio Healthcare System, Cleveland, OH, United States; Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, United States; Division of Infectious Diseases and HIV Medicine, Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, United States; University of Rhode Island College of Pharmacy, Kingston, RI, United States","Dosa, D., Warren Alpert School of Medicine, Brown University, Providence, RI, United States, School of Public Health, Brown University, Providence, RI, United States, Providence VAMC Center of Innovation (COIN), Providence, RI, United States; Jump, R.L.P., Geriatric Research Education and Clinical Center (GRECC) at the VA Northeast Ohio Healthcare System, Cleveland, OH, United States, Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, United States, Division of Infectious Diseases and HIV Medicine, Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, United States; LaPlante, K., Providence VAMC Center of Innovation (COIN), Providence, RI, United States, University of Rhode Island College of Pharmacy, Kingston, RI, United States; Gravenstein, S., Warren Alpert School of Medicine, Brown University, Providence, RI, United States, School of Public Health, Brown University, Providence, RI, United States, Providence VAMC Center of Innovation (COIN), Providence, RI, United States",[No abstract available],,,"Coronavirus disease 2019 (COVID-19) Situation Report – 48 (2020), https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200308-sitrep-48-covid-19.pdf?sfvrsn=16f7ccef_4, World Health Organization Geneva, Switzerland Available at: (Accessed 12 March 2020); Golden, H., Washington nursing home at center of US coronavirus outbreak reports 13 deaths https://www.theguardian.com/world/2020/mar/07/coronavirus-washington-kirkland-life-care-center-deaths, The Guardian. March 7, 2020. Available at: (Accessed 12 March 2020); CDC, Washington State Report First COVID-19 Death (2020), https://www.cdc.gov/media/releases/2020/s0229-COVID-19-first-death.html, Available at: (Accessed 12 March 2020); Centers for Medicare and Medicaid Services (CMS) Nursing Home Data Compendium, 2015 https://www.cms.gov/Medicare/Provider-Enrollment-and-Certification/CertificationandComplianc/Downloads/nursinghomedatacompendium_508-2015.pdf, Available at: (Accessed 12 March 2020); Xing, Z.L., Xue, B., Zhi, A., The Epidemiological Characteristics of an Outbreak of 2019 Novel Coronavirus Diseases (COVID-19) in China. China CDC Weekly 2020;41:145–151 http://www.ne.jp/asahi/kishimoto/clinic/cash/COVID-19.pdf, Available at: (Accessed 12 March 2020); Caramelo, F., Ferreira, N., Oliveiros, B., (2020), Estimation of risk factors for COVID-19 mortality - preliminary results. medRxiv. Available at:. Accessed March 12; Wu, Z., McGoogan, J.M., Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a report of 72,314 cases from the Chinese center for disease control and prevention (2020) JAMA, , [Epub ahead of print]; Daamen, M.A., Hamers, J.P., Gorgels, A.P., Heart failure in nursing home residents; a cross-sectional study to determine the prevalence and clinical characteristics (2015) BMC Geriatr, 15, p. 167; Zarowitz, B.J., O'Shea, T., Chronic obstructive pulmonary disease: Prevalence, characteristics, and pharmacologic treatment in nursing home residents with cognitive impairment (2012) J Manag Care Pharm, 18, pp. 598-606; Interim guidance for healthcare facilities: Preparing for community transmission of COVID-19 in the United States (2020), https://www.cdc.gov/coronavirus/2019-ncov/community/guidance-business-response.html?CDC_AA_refVal=https%3A%2F%2Fwww.cdc.gov%2Fcoronavirus%2F2019-ncov%2Fspecific-groups%2Fguidance-business-response.html, Available at: (Accessed 12 March 2020); Lan, L., Xu, D., Ye, G., Positive RT-PCR test results in patients recovered from COVID-19 (2020) JAMA, , [Epub ahead of print]; Harris-Kojetin, L., Sengupta, M., Park-Lee, E., Long-term care providers and services users in the United States: Data from the National Study of long-term care providers, 2013-2014 (2016) Vital Health Stat 3, , 1–105; x-xii; Bacon, J., Four face charges in deaths of 12 Florida nursing home patients following Hurricane Irma https://www.usatoday.com/story/news/2019/08/26/florida-nursing-home-deaths-hollywood-hills-arrests-expected/2118769001/, USA Today. 2019 August 26, 2019. Available at: (Accessed 12 March 2020)","Dosa, D.; Center for Gerontology and Healthcare Research, Brown University, Box G-121(6), 121 South Main Street, United States; email: david_dosa@brown.edu",,Elsevier Inc.,15258610,,JAMDC,,English,J. Am. Med. Dir. Assoc.,Editorial,Article in Press,Open Access,Scopus,2-s2.0-85081911095,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Khan M.A., Atangana A.",55620329200;55659450400;,Modeling the dynamics of novel coronavirus (2019-nCov) with fractional derivative,2020,Alexandria Engineering Journal,,,,,,,,10.1016/j.aej.2020.02.033,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081910424&doi=10.1016%2fj.aej.2020.02.033&partnerID=40&md5=5174a599de421637d2cd883b09823062,"Faculty of Natural and Agricultural Sciences, University of the Free State, South Africa; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan","Khan, M.A., Faculty of Natural and Agricultural Sciences, University of the Free State, South Africa; Atangana, A., Faculty of Natural and Agricultural Sciences, University of the Free State, South Africa, Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, Taiwan","The present paper describes the mathematical modeling and dynamics of a novel corona virus (2019-nCoV). We describe the brief details of interaction among the bats and unknown hosts, then among the peoples and the infections reservoir (seafood market). The seafood marked are considered the main source of infection when the bats and the unknown hosts (may be wild animals) leaves the infection there. The purchasing of items from the seafood market by peoples have the ability to infect either asymptomatically or symptomatically. We reduced the model with the assumptions that the seafood market has enough source of infection that can be effective to infect people. We present the mathematical results of the model and then formulate a fractional model. We consider the available infection cases for January 21, 2020, till January 28, 2020 and parameterized the model. We compute the basic reproduction number for the data is R0≈2.4829. The fractional model is then solved numerically by presenting many graphical results, which can be helpful for the infection minimization. © 2020 Faculty of Engineering, Alexandria University",Corona virus; Fractional mathematical model; Numerical results; Real data; Stability results,Cell proliferation; Commerce; Viruses; Basic reproduction number; Coronaviruses; Fractional derivatives; Fractional model; Numerical results; Parameterized; Real data; Stability results; Meats,", pp. 1950-2020. , https://www.macrotrends.net/cities/20712/wuhan/population, Wuhan, China Population; (2020), Is the World Ready for the Coronavirus?. Editorial. The New York Times. 29 January 2020. Archived from the original on 30 January; (2020), China virus death toll rises to 41, more than 1,300 infected worldwide. CNBC. 24 January 2020. Archived from the original on 26 January 2020. Retrieved 26 January 2020. Retrieved 30 January; Owolabi, K.M., Atangana, A., Numerical Methods for Fractional Differentiation (2019), Springer Singapore; Owolabi, K.M., Pindza, E., Modeling and simulation of nonlinear dynamical system in the frame of nonlocal and non-singular derivatives (2019) Chaos, Solit. Fract., 1 (127), pp. 146-157; Owolabi, K.M., Atangana, A., Mathematical analysis and computational experiments for an epidemic system with nonlocal and nonsingular derivative (2019) Chaos, Solit. Fract., 1 (126), pp. 41-49; Owolabi, K.M., Shikongo, A., , pp. 1-15. , Fractional operator method on a multi-mutation and intrinsic resistance model, Alexandr. Eng. J., 2020 (in press); Naik, P.A., Zu, J., Owolabi, K.M., Modeling the mechanics of viral kinetics under immune control during primary infection of HIV-1 with treatment in fractional order (2019) Phys. A: Stat. Mech. Its Appl., 13, p. 123816; Shah, S.A.A., Khan, M.A., Farooq, M., Ullah, S., Alzahrani, E.O., A fractional order model for Hepatitis B virus with treatment via Atangana-Baleanu derivative (2019) Physica A, 538, p. 122636; Khan, M.A., Kolebaje, O., Yildirim, A., Ullah, S., Kumam, P., Thounthong, P., Fractional investigations of zoonotic visceral leishmaniasis disease with singular and non-singular kernel (2019) Eur. Phys. J. Plus, 134 (10), p. 481; Jan, R., Khan, M.A., Kumam, P., Thounthong, P., Modeling the transmission of dengue infection through fractional derivatives (2019) Chaos Solit. Fract., 127, pp. 189-216; Wang, W., Khan, M.A., Kumam, P., Thounthong, P., A comparison study of bank data in fractional calculus (2019) Chaos Solit. Fract., 126, pp. 369-384; Khan, M.A., The dynamics of a new chaotic system through the Caputo-Fabrizio and Atanagan-Baleanu fractional operators (2019) Adv. Mech. Eng., 11 (7). , 1687814019866540; Ghanbari, B., Atangana, A., (2020), A new application of fractional Atangana-Baleanu derivatives: Designing ABC-fractional masks in image processing Phys. A: Stat. Mech. Its Appl., 123516; Toufik, M., Atangana, A., New numerical approximation of fractional derivative with non-local and non-singular kernel: application to chaotic models (2017) Eur. Phys. J. Plus, 132 (10), p. 444; Khan, M.A., Ullah, S., Farooq, M., A new fractional model for tuberculosis with relapse via atangana-Baleanu derivative (2018) Chaos, Solit. Fract., 116, pp. 227-238; Alzahrani, E.O., Khan, M.A., Modeling the dynamics of hepatitis E with optimal control (2018) Chaos Solit. Fract., 116, pp. 287-301; (2002), pp. 29-48. , P.van den Driesschea, J. Wamough, Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission, Math. Biosci., 180 (Issues 1–2)","Khan, M.A.; Faculty of Natural and Agricultural Sciences, University of the Free StateSouth Africa; email: altafdir@gmail.com",,Elsevier B.V.,11100168,,,,English,Alexandria Engineering Journal,Article,Article in Press,Open Access,Scopus,2-s2.0-85081910424,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Peña-Otero D., Díaz-Pérez D., de la Rosa-Carrillo D., Bello-Dronda S.",57193739381;57193845677;56150748800;6602709163;,Are we ready for the new coronavirus? [¿Preparados para el nuevo coronavirus?],2020,Archivos de Bronconeumologia,,,,,,,,10.1016/j.arbr.2020.02.003,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081903425&doi=10.1016%2fj.arbr.2020.02.003&partnerID=40&md5=05c930a12e028e0a5a150070d60f2283,"Hospital Sierrallana, Servicio Cántabro de Salud, Torrelavega, Cantabria, Spain; Hospital Universitario Nuestra Señora de Candelaria, Servicio Canario de Salud, Santa Cruz de Tenerife, Tenerife, Spain; Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Servicio de Neumología, Hospital Universitario Miguel Servet, Zaragoza, Spain; Área de Enfermería Respiratoria de la SEPAR, Spain; Área de Tuberculosis e Infecciones Respiratorias (TIR) de la SEPAR, Spain","Peña-Otero, D., Hospital Sierrallana, Servicio Cántabro de Salud, Torrelavega, Cantabria, Spain, Área de Enfermería Respiratoria de la SEPAR, Spain; Díaz-Pérez, D., Hospital Universitario Nuestra Señora de Candelaria, Servicio Canario de Salud, Santa Cruz de Tenerife, Tenerife, Spain, Área de Enfermería Respiratoria de la SEPAR, Spain; de la Rosa-Carrillo, D., Hospital de la Santa Creu i Sant Pau, Barcelona, Spain, Área de Tuberculosis e Infecciones Respiratorias (TIR) de la SEPAR, Spain; Bello-Dronda, S., Servicio de Neumología, Hospital Universitario Miguel Servet, Zaragoza, Spain, Área de Tuberculosis e Infecciones Respiratorias (TIR) de la SEPAR, Spain",[No abstract available],,,"Phelan, A.L., Katz, R., Gostin, L.O., The novel coronavirus originating in Wuhan, China: challenges for global health governance (2020) JAMA, , Jan 30. [Epub ahead of print]; Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) JAMA, , Feb 7. [Epub ahead of print]; Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395, pp. 507-513. , S0140-6736(20)30211-7; Liu, P., Chen, W., Chen, J.P., Viral metagenomics revealed sendai virus and coronavirus infection of Malayan Pangolins (Manis javanica) (2019) Viruses, 11. , pii: E979; 3390/v11110979; Chan, J.F., Yuan, S., Kok, K.H., To, K.K., Chu, H., Yang, J., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, 395, pp. 514-523. , S0140-6736(20)30154-9; https://www.mscbs.gob.es/profesionales/saludPublica/ccayes/alertasActual/nCov-China/documentos/Manejo_urgencias_pacientes_con_COVID-19.pdf, Ministerio de Sanidad. Gobierno de España. Manejo en urgencias y primera atención de pacientes con sospecha de COVID-19. Informe Técnico. DOI: 10.13140/RG.2.2.12122.90568 [actualizado 23 Feb 2020; consultado 23 Feb 2020]. Disponible en:; Sheahan, T.P., Sims, A.C., Leist, S.R., Schäfer, A., Won, J., Brown, A.J., Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV (2020) Nat Commun, 11, p. 222; Russell, C.D., Millar, J.E., Baillie, J.K., Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury (2020) Lancet, 395, pp. 473-475. , S0140-6736(20)30317-2; Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med; Centers for Disease Control and Prevention, https://www.cdc.gov/coronavirus/2019-ncov/about/transmission.html, How 2019-nCoV spreads [actualizado 11 Feb 2020; consultado 14 Feb 2020]. Disponible en:; Kupferschmidt, K., Study claiming new coronavirus can be transmitted by people without symptoms was flawed (2020) Science, , https://www.sciencemag.org/news/2020/02/paper-non-symptomatic-patient-transmitting-coronavirus-wrong, (published online Feb 3); World Health Organization, https://www.who.int/docs/default-source/documents/advice-on-the-use-of-masks-2019-ncov.pdf, Advice on the use of masks in the community, during home care and in health care settings in the context of the novel coronavirus (2019-nCoV) outbreak. Interim guidance [consultado 12 Feb 2020]. Disponible en: Updated 29/I/2020; Centers for Disease Control and Prevention, https://www.cdc.gov/coronavirus/2019-ncov/hcp/guidance-for-ems.html, Interim guidance for emergency medical services (EMS) systems and 911 public safety answering points (PSAPs) for 2019-nCoV in the United States [consultado 12 Feb 2020]. Disponible en: Updated 06/II/2020; https://www.mscbs.gob.es/profesionales/saludPublica/ccayes/alertasActual/nCov-China/documentos/ITCoronavirus.pdf, Ministerio de Sanidad. Gobierno de España. Informe Técnico. Nuevo coronavirus 2019-nCoV. Instituto de Salud Carlos III. Dirección General de Salud Pública, Calidad e Innovación. Centro de Coordinación de Alertas y Emergencias Sanitarias [consultado 12 Feb 2020]. Disponible en: Updated 10/II/2020; World Health Organization, https://apps.who.int/iris/handle/10665/330674, Infection prevention and control during health care when novel coronavirus (nCoV) infection is suspected: Interim guidance [consultado 11 Feb 2020]. Disponible en: Licencia: CC BY-NC-SA 3.0 IGO. Updated 25/I/2020; https://www.ecdc.europa.eu/en/publications-data/guidelines-use-non-pharmaceutical-measures-delay-and-mitigate-impact-2019-ncov, European Centre for Disease Prevention and Control. Guidelines for the use of non-pharmaceutical measures to delay and mitigate the impact of 2019-nCoV [consultado 12 Feb 2020]. Disponible en: Updated 10/II/2020; Chen, J., Pathogenicity and transmissibility of 2019-nCoV-A quick overview and comparison with other emerging viruses (2020) Microbes Infect, , Feb 4. S1286-4579(20)30026-5. [Epub ahead of print]","Bello-Dronda, S.; Servicio de Neumología, Hospital Universitario Miguel ServetSpain; email: sbello@salud.aragon.es",,Elsevier Doyma,3002896,,ARBRD,,English; Spanish,Arch. Bronconeumol.,Editorial,Article in Press,Open Access,Scopus,2-s2.0-85081903425,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Hunter P.,36246120000;,The spread of the COVID-19 coronavirus: Health agencies worldwide prepare for the seemingly inevitability of the COVID-19 coronavirus becoming endemic,2020,EMBO Reports,,,,,,,,10.15252/embr.202050334,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081898418&doi=10.15252%2fembr.202050334&partnerID=40&md5=6b9468e55df44d5b5320ade6ff1d37d6,"London, United Kingdom","Hunter, P., London, United Kingdom",[No abstract available],,,"Smith Richard, D., Responding to global infectious disease outbreaks: lessons from SARS on the role of risk perception, communication and management (2006) Soc Sci Med, 63, p. 311323; Boni, M.F., Nguyen, T.D., de Jong, M.D., van Doorn, H.R., Virulence attenuation during an influenza A/H5N1 pandemic (2013) Philos Trans R Soc Lond B Biol Sci, 368, p. 20120207; Denison, M.R., Graham, R.L., Donaldson, E.F., Eckerle, L.D., Baric, R.S., Coronaviruses: an RNA proofreading machine regulates replication fidelity and diversity (2011) RNA Biol, 8, pp. 270-279; Morens, D.M., Taubenberger, J.K., Fauci, A.S., Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparedness (2008) J Infect Dis, 198, pp. 962-970; Chan, J.F., Yuan, S., Kok, K.H., To, K.K., Chu, H., Yang, J., Xing, F., Poon, R.W., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, 395, pp. P514-P523; Qian, Z., Travanty, E.A., Oko, L., Edeen, K., Berglund, A., Wang, J., Ito, Y., Mason, R.J., Innate immune response of human alveolar type II cells infected with severe acute respiratory syndrome-coronavirus (2013) Am J Respir Cell Mol Biol, 48, pp. 742-748","Hunter, P.United Kingdom; email: ph@philiphunter.com",,Wiley-VCH Verlag,1469221X,,ERMEA,,English,EMBO Rep.,Note,Article in Press,,Scopus,2-s2.0-85081898418,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Vankadari N., Wilce J.A.",57204147743;7004850054;,Emerging WuHan (COVID-19) coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26,2020,Emerging Microbes and Infections,9,1,,601,604,,,10.1080/22221751.2020.1739565,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081893352&doi=10.1080%2f22221751.2020.1739565&partnerID=40&md5=51aa7e1c01618a80eeefd59c4c6c1c2e,"Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia","Vankadari, N., Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia; Wilce, J.A., Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia","The recent outbreak of pneumonia-causing COVID-19 in China is an urgent global public health issue with an increase in mortality and morbidity. Here we report our modelled homo-trimer structure of COVID-19 spike glycoprotein in both closed (ligand-free) and open (ligand-bound) conformation, which is involved in host cell adhesion. We also predict the unique N- and O-linked glycosylation sites of spike glycoprotein that distinguish it from the SARS and underlines shielding and camouflage of COVID-19 from the host the defence system. Furthermore, our study also highlights the key finding that the S1 domain of COVID-19 spike glycoprotein potentially interacts with the human CD26, a key immunoregulatory factor for hijacking and virulence. These findings accentuate the unique features of COVID-19 and assist in the development of new therapeutics. © 2020, © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd.",CD26; Coronavirus; docking; glycosylation; spike glycoprotein,"dipeptidyl peptidase IV; glycan; ligand; virus glycoprotein; coronavirus spike glycoprotein; dipeptidyl peptidase IV; DPP4 protein, human; polysaccharide; protein binding; severe acute respiratory syndrome coronavirus 2; binding site; cell adhesion; glycosylation; host cell; host resistance; immunoregulation; Letter; nonhuman; priority journal; protein conformation; protein domain; protein protein interaction; protein structure; SARS coronavirus; severe acute respiratory syndrome coronavirus 2; virus strain; Betacoronavirus; chemistry; genetics; human; metabolism; molecular model; protein quaternary structure; Betacoronavirus; Dipeptidyl Peptidase 4; Humans; Models, Molecular; Polysaccharides; Protein Binding; Protein Structure, Quaternary; Spike Glycoprotein, Coronavirus","Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395 (10223), pp. 497-506; Lu, H., Stratton, C.W., Tang, Y.W., Outbreak of pneumonia of unknown etiology in Wuhan China: the mystery and the miracle (2020) J Med Virol, 92 (4), pp. 401-402; Xiong, X.L., Tortorici, M.A., Snijder, J., Glycan shield and fusion activation of a deltacoronavirus spike glycoprotein fine-tuned for enteric infections (2018) J Virol, 92 (4), pp. e01628-e1617; Song, W.F., Gui, M., Wang, X., Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2 (2018) PLoS Pathog, 14 (8), p. e1007236; Millet, J.K., Kien, F., Cheung, C.-Y., Ezrin interacts with the SARS coronavirus spike protein and restrains infection at the entry stage (2012) Plos One, 7 (11); Xu, X., Chen, P., Wang, J., (2020) Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission, 63 (3), pp. 457-460. , SCIENCE CHINA Life Sciences; Grum-Tokars, V., Ratia, K., Begaye, A., Evaluating the 3C-like protease activity of SARS-coronavirus: recommendations for standardized assays for drug discovery (2008) Virus Res, 133 (1), pp. 63-73; Watanabe, Y., Bowden, T.A., Wilson, I.A., Exploitation of glycosylation in enveloped virus pathobiology (2019) Biochim Biophys Acta Gen Subj, 1863 (10), pp. 1480-1497; Morimoto, C., Schlossman, S.F., The structure and function of CD26 in the T-cell immune response (1998) Immunol Rev, 161, pp. 55-70; Wang, Q., Qi, J., Yuan, Y., Bat origins of MERS-CoV supported by bat coronavirus HKU4 usage of human receptor CD26 (2014) Cell Host Microbe, 16 (3), pp. 328-337","Vankadari, N.; Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash UniversityAustralia; email: Naveen.vankadari@monash.edu",,Taylor and Francis Ltd.,22221751,,,32178593,English,Emerg. Microbes Infect.,Letter,Final,Open Access,Scopus,2-s2.0-85081893352,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Di Pasquale G.,57215474538;,COVID-19 coronavirus: What implications for cardiology? [Coronavirus COVID-19: Quali implicazioni per la Cardiologia?],2020,Giornale Italiano di Cardiologia,21,4,,243,245,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081892769&partnerID=40&md5=fc5833b785f1123b98252741e7224657,"Giornale Italiano di Cardiologia, Italy","Di Pasquale, G., Giornale Italiano di Cardiologia, Italy",[No abstract available],,cardiology; Coronavirinae; Editorial; Severe acute respiratory syndrome coronavirus 2,"Coutsoumbas, G.V., Di Pasquale, G., Influenza e rischio di infarto miocardico acuto: Ruolo protettivo della vaccinazione anti-influenzale. un motivo in più per vaccinare (2018) G Ital Cardiol, 19, pp. 620-627; Madjid, M., Casscells, S.W., Of birds and men: Cardiologists' role in influenza pandemic (2004) Lancet, 364, p. 1309; Chen, H., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study (2020) Lancet, 395, pp. 507-513; Wang, D., Hu, B., Hu, C., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) JAMA, , Feb 7. [Epub ahead of print]; Guan, W., Ni, Z., Hu, Y., Clinical characteristics of coronavirus disease 2019 in China N Engl J Med 2020, , Feb 28. [Epub ahead of print]; Wu, Z., McGoogan, J.M., Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a report of 72 314 cases from the Chinese center for disease control and prevention (2020) JAMA, , Feb 24 [Epub ahead of print]; (2020) ACC Clinical Bulletin: Cardiac Implications of Novel Coronavirus (COVID-19), , https://www.acc.org/~/media/665AFA1E710B4B3293138D14BE8D1213.pdf, American College of Cardiology. [accessed March 4]; Morens, D.M., Taubenberger, J.K., Influenza cataclysm, 1918 (2018) N Engl J Med, 379, pp. 2285-2287; Collins, S.D., Excess mortality from causes other than influenza and pneumonia during influenza epidemics (1932) Public Health Rep, 47, pp. 2159-2189; Corrales-Medina, V.F., Madjid, M., Musher, D.M., Role of acute infection in triggering acute coronary syndromes (2010) Lancet Infect Dis, 10, pp. 83-92; Halhogbani, T., Acute myocarditis associated with novel middle east respiratory syndrome coronavirus (2016) Ann Saudi Med, 36, pp. 78-80; Li, S.S., Cheng, C., Fu, C., Left ventricular performance in patients with severe acute respiratory syndrome: A 30-day echocardiographic follow-up study (2003) Circulation, 108, pp. r93-r98; Holland, E.M., Moss, T.J., Acute noncardiovascular illness in the cardiac intensive care unit (2017) J Am Coll Cardiol, 69, pp. 1999-2007; Barnes, M., Heywood, A.E., Mahimbo, A., Rahman, B., Newal, A.T., Macintyre, C.R., Acute myocardial infarction and influenza: A meta-analysis of case-control studies (2015) Heart, 101, pp. 1738-1747; Chang, M.H., Wu, H.H., Shih, C.I., Chen, Y.T., Kuo, S.C., Chen, T.L., Association between influenza vaccination and reduced risks of major adverse cardiovascular events in elderly patients (2017) Am Heart J, 193, pp. 1-7; Knuuti, J., Wijns, W., Saraste, A., 2019 ESC guidelines for the diagnosis and management of chronic coronary syndromes: The task force for the diagnosis and management of chronic coronary syndromes of the european society of cardiology (ESC) (2020) Eur Heart J, 41, pp. 407-477; Ponikowski, P., Voors, A.A., Anker, S.D., 2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: The task force for the diagnosis and treatment of acute and chronic heart failure of the european society of cardiology (ESC). Developed with the special contribution of the heart failure association (HFA) of the ESC (2016) Eur Heart J, 37, pp. 2129-2200; Pittet, D., Allegranzi, B., Boyce, J., The world health organization guidelines on hand hygiene in health care and their consensus recommendations (2009) Infect Control Hosp Epidemiol, 30, pp. 611-622","Di Pasquale, G.Via San Ruffillo 10/A, Italy; email: g.dipa@libero.it",,Il Pensiero Scientifico Editore s.r.l.,18276806,,,32202553,Italian,G. Ital. Cardiol.,Editorial,Final,,Scopus,2-s2.0-85081892769,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Brichacek B., Bukrinsky M.",56018924100;7007172946;,Coronavirus pandemic and HIV infection,2020,Open AIDS Journal,14,1,,10,,,,10.2174/1874613602014010010,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081752113&doi=10.2174%2f1874613602014010010&partnerID=40&md5=144e070f6ea5cc37672fea1cd73e63e8,"The George Washington University School of Medicine and Health Sciences, Washington, DC 20037, United States","Brichacek, B., The George Washington University School of Medicine and Health Sciences, Washington, DC 20037, United States; Bukrinsky, M., The George Washington University School of Medicine and Health Sciences, Washington, DC 20037, United States",[No abstract available],,angiotensin converting enzyme 2; antiretrovirus agent; proteinase inhibitor; 2019 novel coronavirus; clinical outcome; coronavirus disease 2019; coughing; Editorial; fever; human; Human immunodeficiency virus infection; immune response; Measles virus; mortality rate; nonhuman; pandemic; pneumonia; priority journal; prognosis; SARS coronavirus; virus load; virus transmission; weakness,,"Bukrinsky, M.; The George Washington University School of Medicine and Health SciencesUnited States; email: mbukrins@gwu.edu",,Bentham Science Publishers,18746136,,,,English,Open AIDS J.,Editorial,Final,Open Access,Scopus,2-s2.0-85081752113,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Aminnejad R., Salimi A., Saeidi M.",56721304500;23390131400;55212492600;,Lidocaine during intubation and extubation in patients with coronavirus disease (COVID-19),2020,Canadian Journal of Anesthesia,,,,,,,,10.1007/s12630-020-01627-2,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081744684&doi=10.1007%2fs12630-020-01627-2&partnerID=40&md5=099ba2ef816454492b54be9d6c1c7da1,"Department of Anesthesiology and Critical Care, Qom University of Medical Sciences, Qom, Iran; Department of Anesthesiology and Critical Care, Shahid Beheshti Medical University, Tehran, Iran","Aminnejad, R., Department of Anesthesiology and Critical Care, Qom University of Medical Sciences, Qom, Iran, Department of Anesthesiology and Critical Care, Shahid Beheshti Medical University, Tehran, Iran; Salimi, A., Department of Anesthesiology and Critical Care, Shahid Beheshti Medical University, Tehran, Iran; Saeidi, M., Department of Anesthesiology and Critical Care, Qom University of Medical Sciences, Qom, Iran",[No abstract available],,,"Wax, R.S., Christian, M.D., Practical recommendations for critical care and anesthesiology teams caring for novel coronavirus (2019-nCoV) patients (2020) Can J Anesth; Deng, S.Q., Peng, H.J., Characteristics of and public health responses to the coronavirus disease 2019 outbreak in China (2020) J Clin Med; Pandey, C.K., Raza, M., Ranjan, R., Intravenous lidocaine 0.5 mg.kg−1 effectively suppresses fentanyl-induced cough (2005) Can J Anesth, 52, pp. 172-175; Peng, P.W., Ho, P.L., Hota, S.S., Outbreak of a new coronavirus: what anaesthetists should know (2020) Br J Anaesth; Yang, S.S., Wang, N.N., Postonogova, T., Intravenous lidocaine to prevent postoperative airway complications in adults: a systematic review and meta-analysis (2020) Br J Anaesth, 124, pp. 314-323","Aminnejad, R.; Department of Anesthesiology and Critical Care, Qom University of Medical SciencesIran; email: r.aminnejad@yahoo.com",,Springer,0832610X,,CJOAE,,English,Can. J. Anesth.,Letter,Article in Press,Open Access,Scopus,2-s2.0-85081744684,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Peng Y., Zhou Y.-H.",57215725012;8062316400;,Is novel coronavirus disease (COVID-19) transmitted through conjunctiva?,2020,Journal of Medical Virology,,,,,,,,10.1002/jmv.25753,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081743468&doi=10.1002%2fjmv.25753&partnerID=40&md5=b02c13984c0348000307148cd9e40572,"Department of Internal Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu, China; Department of Laboratory Medicine and Infectious Diseases, Jiangsu Key Laboratory for Molecular Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu, China","Peng, Y., Department of Internal Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu, China; Zhou, Y.-H., Department of Laboratory Medicine and Infectious Diseases, Jiangsu Key Laboratory for Molecular Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu, China",[No abstract available],,,"Xia, J., Tong, J., Liu, M., Shen, Y., Guo, D., Evaluation of coronavirus in tears and conjunctival secretions of patients with SARS-CoV-2 infection (2020) J Med Virol, , https://doi.org/10.1002/jmv.25725; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395 (10223), pp. 497-506. , https://doi.org/10.1016/S0140-6736(20)30183-5; Wang, D., Hu, B., Hu, C., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) JAMA, , https://doi.org/10.1001/jama.2020.1585; Guan, W., Ni, Z., Hu, Y., Clinical characteristics of coronavirus disease 2019 in China (2020) N Engl J Med, , https://doi.org/10.1056/NEJMoa2002032; Sun, P., Qie, S., Liu, Z., Ren, J., Li, K., Xi, J., Clinical characteristics of 50466 hospitalized patients with 2019-nCoV infection (2020) J Med Virol, , https://doi.org/10.1002/jmv.25735; https://www.who.int/docs/default-source/coronaviruse/who-china-joint-mission-on-covid-19-final-report.pdf, February 16-24, 2020., Accessed 5 March 2020; Zhou, P., Yang, X.L., Wang, X.G., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature, , https://doi.org/10.1038/s41586-020-2012-7; Hamming, I., Timens, W., Bulthuis, M., Lely, A., Navis, G., van Goor, H., Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis (2004) J Pathol, 203 (2), pp. 631-637. , https://doi.org/10.1002/path.1570; Lu, C.W., Liu, X.F., Jia, Z.F., 2019-nCoV transmission through the ocular surface must not be ignored (2020) Lancet, 395 (10224). , https://doi.org/10.1016/S0140-6736(20)30313-5; Dai, X., Peking University Hospital Wang Guangfa disclosed treatment status on Weibo and suspected infection without wearing goggles, , http://www.bjnews.com.cn/news/2020/01/23/678189.html, 23 January 2020., Accessed 29 February 2020","Zhou, Y.-H.; Department of Laboratory Medicine and Infectious Diseases, Jiangsu Key Laboratory for Molecular Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical SchoolChina; email: zgr03summer@126.com",,John Wiley and Sons Inc.,1466615,,JMVID,,English,J. Med. Virol.,Letter,Article in Press,Open Access,Scopus,2-s2.0-85081743468,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Chen R., Chen J., Meng Q.-T.",56925751400;57215782223;57215722870;,Chest computed tomography images of early coronavirus disease (COVID-19),2020,Canadian Journal of Anesthesia,,,,,,,1,10.1007/s12630-020-01625-4,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081733274&doi=10.1007%2fs12630-020-01625-4&partnerID=40&md5=078f678b0dff74d2dfde20b8ef250973,"Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, China; Department of Anesthesiology, East Hospital, Renmin Hospital of Wuhan University, Wuhan, China; Department of Radiology, Renmin Hospital of Wuhan University, Wuhan, China","Chen, R., Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, China, Department of Anesthesiology, East Hospital, Renmin Hospital of Wuhan University, Wuhan, China; Chen, J., Department of Radiology, Renmin Hospital of Wuhan University, Wuhan, China; Meng, Q.-T., Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, China, Department of Anesthesiology, East Hospital, Renmin Hospital of Wuhan University, Wuhan, China",[No abstract available],,,"(2019), 48. , https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200308-sitrep-48-covid-19.pdf?sfvrsn=16f7ccef_4, (COVID-19) Situation Report –, Available from, accessed March 2020; Yang, X., Yu, Y., Xu, J., Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study (2020) Lancet Respir Med; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506. , COI: 1:CAS:528:DC%2BB3cXhs1Kqu7c%3D; Li, Y., Xia, L., Coronavirus Disease 2019 (COVID-19): Role of chest CT in diagnosis and management (2020) AJR Am J Roentgenol","Meng, Q.-T.; Department of Anesthesiology, Renmin Hospital of Wuhan UniversityChina; email: mengqingtao2018@126.com",,Springer,0832610X,,CJOAE,32162211,English,Can. J. Anesth.,Note,Article in Press,Open Access,Scopus,2-s2.0-85081733274,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, [No author name available],[No author id available],Is the useful information about the coronavirus (SARS-CoV-2) not controlled? [L'informazione utile sul coronavirus (SARS-CoV-2) non è controllata?],2020,Recenti Progressi in Medicina,111,3,,169,170,,,10.1701/3315.32860,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081659485&doi=10.1701%2f3315.32860&partnerID=40&md5=c5d2239cdec555d982c15b6ba6c644ed,,,[No abstract available],,,"(2016) Statement on Data Sharing in Public Health Emergencies, , Wellcome Foundation 16 febbraio; (2020) Sharing Research Data and Findings Relevant to the Novel Coronavirus (COVID-19) Outbreak, , Wellcome Foundation 31 gennaio; Calling all coronavirus researchers: Keep sharing, stay open (2020) Nature, , Editoriale. 4 febbraio; https://www.springernature.com/gp/researchers/campaigns/coronavirus; https://www.nejm.org/coronavirus; https://www.healthmap.org/covid-19/; https://jamanetwork.com/journals/jama/pages/coronavirus-alert; https://www.bmj.com/coronavirus?int_source=wisepops&int_medium=wisepops&int_campaign=DAA_CoronaVirus_Jan24; https://www.thelancet.com/coronavirus?dgcid=kr_pop-up_tlcoronavirus20; https://www.elsevier.com/connect/coronavirus-information-center; http://www.salute.gov.it/nuovocoronavirus; https://www.epicentro.iss.it/coironavirus/; https://www.who.int/emergencies/diseases/novel-coronavirus-2019; https://www.fimp.pro/informativa-coronavirus?fbclid=IwAR3seIQpMhjFQ6xFGDB4Uar5K9q-hNCFZaXVTOdGA05DdXJ6WEuOU8xroqs; http://www.fimmg.org/index.php?action=pages&m=view&p=43&art=3810; https://www.evidenceaid.org/coronavirus-resources/; https://www.cochranelibrary.com/collections/doi/SC000039/full; https://www.uptodate.com/contents/coronaviruses?utm_source=press-release&utm_medium=website&utm_campaign=coronavirus-pr; https://www.uptodate.com/contents/coronaviruses?utm_source=press-release&utm_medium=website&utm_campaign=coronavirus-pr",,,Il Pensiero Scientifico Editore s.r.l.,341193,,RPMDA,32157266,Italian,Recenti Prog. Med.,Short Survey,Final,,Scopus,2-s2.0-85081659485,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhang S., Diao M.Y., Duan L., Lin Z., Chen D.",57215062681;55630446600;57210011786;8866419800;55724974400;,"The novel coronavirus (SARS-CoV-2) infections in China: prevention, control and challenges",2020,Intensive Care Medicine,46,4,,591,593,,1,10.1007/s00134-020-05977-9,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081627160&doi=10.1007%2fs00134-020-05977-9&partnerID=40&md5=3f6c77a063630c3bccbe55cb050e42f9,"Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China; Department of Critical Care Medicine, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, China; Department of Emergency and Critical Care Medicine, Changzheng Hospital, Naval Medical University (Second Military Medical University), Shanghai, 200433, China","Zhang, S., Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China; Diao, M.Y., Department of Critical Care Medicine, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, China; Duan, L., Department of Emergency and Critical Care Medicine, Changzheng Hospital, Naval Medical University (Second Military Medical University), Shanghai, 200433, China; Lin, Z., Department of Emergency and Critical Care Medicine, Changzheng Hospital, Naval Medical University (Second Military Medical University), Shanghai, 200433, China; Chen, D., Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China",[No abstract available],,,"(2020) The Latest Situation of New Coronavirus Pneumonia, , https://www.nhc.gov.cn/xcs/yqfkdt/202002/4a1b1ec6c03548099de1c3aa935d04fd.shtml; (2020) Coronavirus Disease (COVID-19) Situation Report-26, , https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200215-sitrep-26-covid-19.pdf?sfvrsn=a4cc6787_2; Li, Q., Guan, X.H., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med; Bettencourt, L.M., Ribeiro, R.M., Real time Bayesian estimation of the epidemic potential of emerging infectious diseases (2008) PLoS ONE, 3 (5); Rothe, C., Schunk, M., Sothmann, P., Transmission of 2019-nCoV infection from an asymptomatic contact in Germany [published online January 28, 2020] (2020) N Engl J Med","Chen, D.; Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of MedicineChina; email: chendechangsh@hotmail.com",,Springer,3424642,,ICMED,32123989,English,Intensive Care Med.,Letter,Final,Open Access,Scopus,2-s2.0-85081627160,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Duarte R., Furtado I., Sousa L., Carvalho C.",27267515900;57213817775;57215663136;36479857300;,"The 2019 novel Coronavirus (2019-NCoV): Novel virus, old challenges [O Novo Coronavírus (2019-nCoV): Novo Vírus, Desafios Antigos]",2020,Acta Medica Portuguesa,33,3,,155,157,,1,10.20344/amp.13547,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081615907&doi=10.20344%2famp.13547&partnerID=40&md5=93d464f2a7c9eeddd79581502e4e3e21,"Departamento de Epidemiologia, Faculdade de Medicina, Universidade do Porto, Porto, Portugal; Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal; Serviço de Infeciologia, Centro Hospitalar Universitário do Porto, Porto, Portugal; Infectious Disease Epidemiology and Preparedness Department, Statens Serum Institut, Copenhaga, Denmark; Unidade Multidisciplinar de Investigação Biomédica (UMIB), Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal","Duarte, R., Departamento de Epidemiologia, Faculdade de Medicina, Universidade do Porto, Porto, Portugal, Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal; Furtado, I., Serviço de Infeciologia, Centro Hospitalar Universitário do Porto, Porto, Portugal; Sousa, L., Infectious Disease Epidemiology and Preparedness Department, Statens Serum Institut, Copenhaga, Denmark; Carvalho, C., Unidade Multidisciplinar de Investigação Biomédica (UMIB), Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal",[No abstract available],Coronavirus; Coronavirus Infections; Disease Outbreaks,baricitinib; 2019 novel coronavirus; basic reproduction number; case fatality rate; coronavirus disease 2019; Editorial; epidemic; global health; health education; health service; human; nonhuman; pandemic; pneumonia; quarantine; social distance; virus transmission,"Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med; (2020) N Engl J Med, , press); Imai, N.D., Cori, A., Riley, S., Ferguson, N.M., (2020) Report 2: Estimating the Potential Total Number of Novel Coronavirus Cases in Wuhan City, China, , https://www.imperial.ac.uk/mrc-global-infectious-disease-analysis/news-wuhancoronavirus/, accessed 2020 Jan 31; Statement on the Second Meeting of the International Health Regulations (2005) Emergency Committee Regarding the Outbreak of Novel Coronavirus (2019-nCoV). 2020, , https://www.who.int/news-room/detail/30-01-2020-statement-on-the-second-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-outbreak-of-novel-coronavirus-(2019-ncov, accessed 2020 Jan 31; Ji, W., Wang, W., Zhao, X., Zai, J., Li, X., Homologous recombination within the spike glycoprotein of the newly identified coronavirus may boost cross-species transmission from snake to human (2020) J Med Virol, , press); Lu, R., Zhao, X., Li, J., Niu, P., Yang, B., Wu, H., Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding (2020) Lancet, , press); Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, , press); (2020) Novel Coronavirus(2019-nCoV) Situation Report - 15., , https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200204-sitrep-15-ncov.pdf?sfvrsn=88fe8ad6_2, accessed 2020 Jan 31; (2020) 2019-nCoV Prevention & Treatment., , https://www.cdc.gov/coronavirus/2019-ncov/about/prevention-treatment.html, accessed 2020 Jan 31; Richardson, P.G., Griffin, I., Tucker, C., Smith, D., Oechsle, O., Phelan, A., Baricitinib as potential treatment for 2019-nCoV acute respiratory disease (2020) Lancet, , press); Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med, , press); Imai, N.C., Dorigatti, I., Baguelin, M., Donnelly, C., Riley, S., Ferguson, N.M., Report 3: Transmissibility of 2019-nCoV. 2020, , https://www.imperial.ac.uk/media/imperial-college/medicine/sph/ide/gida-fellowships/Imperial-2019-nCoV-transmissibility.pdf, accessed 2020 Jan 31; Rothe, C., Schunk, M., Sothmann, P., Bretzel, G., Froeschl, G., Wallrauch, C., Transmission of 2019-nCoV infection from an asymptomatic contact in Germany (2020) N Engl J Med, , press); Kupferschmidt, K., Study claiming new coronavirus can be transmitted by people without symptoms was flawed (2020) ScienceMag, , https://www.sciencemag.org/news/2020/02/paper-non-symptomatic-patient-transmittingcoronavirus-wrong, accessed 2020 Jan 31; Kickbusch, I., Leung, G., Response to the emerging novel coronavirus outbreak (2020) BMJ, 368, p. m406; Mahase, E., China coronavirus: What do we know so far? (2020) BMJ, 368, p. m308; Wu, J.T., Leung, K., Leung, G.M., Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: A modelling study Lancet, , press); (2019) Global Health Security Index, , https://www.ghsindex.org/wp-content/uploads/2019/10/2019-Global-Health-Security-Index.pdf, accessed 2020 Jan 31; Gates, B., (2017) Speech at the Munich Security Conference, , https://www.gatesfoundation.org/MediaCenter/Speeches/2017/05/Bill-Gates-Munich-Security-Conference, accessed 2020 Jan 31","Duarte, R.; Departamento de Epidemiologia, Faculdade de Medicina, Universidade do PortoPortugal; email: rdmelo@med.up.pt",,CELOM,0870399X,,AMPOD,32023427,English,Acta Med. Port.,Editorial,Final,Open Access,Scopus,2-s2.0-85081615907,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhang T., He Y., Xu W., Ma A., Yang Y., Xu K.-F.",57215575915;57215656943;57200720291;57215664662;57200724854;7403282099;,Clinical trials for the treatment of Coronavirus disease 2019 (COVID-19): A rapid response to urgent need,2020,Science China Life Sciences,,,,,,,,10.1007/s11427-020-1660-2,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081610362&doi=10.1007%2fs11427-020-1660-2&partnerID=40&md5=055145340acd4f84747bd9779f43a290,"Department of Internal Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China; Department of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, College of Medicine, Xiamen University, Xiamen, 361003, China","Zhang, T., Department of Internal Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China; He, Y., Department of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China; Xu, W., Department of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China; Ma, A., Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital, College of Medicine, Xiamen University, Xiamen, 361003, China; Yang, Y., Department of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China; Xu, K.-F., Department of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China",[No abstract available],,,"Chan, K.S., Lai, S.T., Chu, C.M., Tsui, E., Tarn, C.Y., Wong, M.M., Tse, M.W., Sung, J., Treatment of severe acute respiratory syndrome with lopinavir/ritonavir: a multicentre retrospective matched cohort study (2003) Hong Kong Med J, 9, pp. 399-406. , COI: 1:STN:280:DC%2BD3srpsFKhuw%3D%3D, PID: 14660806; Chen, Y., Guo, J.J., Healy, D.P., Zhan, S., Effect of integrated traditional Chinese medicine and western medicine on the treatment of severe acute respiratory syndrome: A meta-analysis (2007) Pharmacy pract (Granada Ed impr), 5, pp. 1-9. , COI: 1:CAS:528:DC%2BD1cXivFKgtbY%3D; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Gu, X., Clinical features of patients infected with 2019 novel Coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506. , COI: 1:CAS:528:DC%2BB3cXhs1Kqu7c%3D; Maxmen, A., More than 80 clinical trials launch to test Coronavirus treatments (2020) Nature, 578, pp. 347-348; Wang, M., Cao, R., Zhang, L., Yang, X., Liu, J., Xu, M., Shi, Z., Xiao, G., Remdesivir and chloroquine effectively inhibit the recently emerged novel Coronavirus (2019-nCoV) in vitro (2020) Cell Res","Xu, K.-F.; Department of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical SciencesChina; email: xukf@pumch.cn",,Science in China Press,16747305,,,,English,Sci. China Life Sci.,Article,Article in Press,Open Access,Scopus,2-s2.0-85081610362,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Arabi Y.M., Murthy S., Webb S.",57211811296;36247670800;24774575800;,COVID-19: a novel coronavirus and a novel challenge for critical care,2020,Intensive Care Medicine,,,,,,,2,10.1007/s00134-020-05955-1,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081601171&doi=10.1007%2fs00134-020-05955-1&partnerID=40&md5=b729f3759e53f863bd59cfc42797f686,"Intensive Care Department, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; King Saud Bin Abdulaziz University for Health Sciences, ICU 1425, PO Box 22490, Riyadh, 11426, Saudi Arabia; University of British Columbia, Vancouver, BC V6H 3V4, Canada; School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia","Arabi, Y.M., Intensive Care Department, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia, King Saud Bin Abdulaziz University for Health Sciences, ICU 1425, PO Box 22490, Riyadh, 11426, Saudi Arabia; Murthy, S., University of British Columbia, Vancouver, BC V6H 3V4, Canada; Webb, S., School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia",[No abstract available],,,"Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., Zhao, X., Research, T., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382, pp. 727-733. , COI: 1:CAS:528:DC%2BB3cXjslGmsrc%3D; Chan, J.F., Yuan, S., Kok, K.H., To, K.K., Chu, H., Yang, J., Xing, F., Yuen, K.Y., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, 395, pp. 514-523. , COI: 1:CAS:528:DC%2BB3cXhs1Ojsro%3D; Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Ren, R., Feng, Z., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med; Zhou, P., Yang, X.-L., Wang, X.-G., Hu, B., Zhang, L., Zhang, W., Si, H.-R., Shi, Z.-L., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature.; Lu, R., Zhao, X., Li, J., Niu, P., Yang, B., Wu, H., Wang, W., Tan, W., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet, 395, pp. 565-574; (2019) Novel Coronavirus (2019-Ncov). Situation Report—9, , https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200301-sitrep-41-covid-19.pdf?sfvrsn=6768306d_2, Accessed 2 Mar 2020; Wuhan Coronavirus (2019-Ncov) Global Cases (By Johns Hopkins CSSE), , https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6, Accessed 2 Mar 2020; Wang, C., Horby, P.W., Hayden, F.G., Gao, G.F., A novel coronavirus outbreak of global health concern (2020) Lancet, 395, pp. 470-473; Perlman, S., Another decade, another coronavirus (2020) N Engl J Med., 382, pp. 760-762; Munster, V.J., Koopmans, M., van Doremalen, N., van Riel, D., de Wit, E., A novel coronavirus emerging in China—key questions for impact assessment (2020) N Engl J Med, 382, pp. 692-694. , COI: 1:CAS:528:DC%2BB3cXjslGltrk%3D; Brun-Buisson, C., SARS: the challenge of emerging pathogens to the intensivist (2003) Intensive Care Med, 29, pp. 861-862; Al-Dorzi, H.M., Aldawood, A.S., Khan, R., Baharoon, S., Alchin, J.D., Matroud, A.A., Al Johany, S.M., Arabi, Y.M., The critical care response to a hospital outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infection: an observational study (2016) Ann Intensive Care, 6, p. 101; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Cao, B., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506. , COI: 1:CAS:528:DC%2BB3cXhs1Kqu7c%3D; Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Zhang, L., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395, pp. 507-513. , COI: 1:CAS:528:DC%2BB3cXhvFOmsb8%3D; Wang, D., Hu, B., Hu, C., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China (2020) JAMA; Yang, X., Yu, Y., Xu, J., Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study (2020) Lancet Respir Med; Arabi, Y.M., Al-Omari, A., Mandourah, Y., Al-Hameed, F., Sindi, A.A., Alraddadi, B., Shalhoub, S., Balkhy, H.H., Critically Ill patients with the Middle East respiratory syndrome: a multicenter retrospective cohort study (2017) Crit Care Med, 45, pp. 1683-1695; Iwasenko, J.M., Cretikos, M., Paterson, D.L., Gibb, R., Webb, S.A., Smith, D.W., Blyth, C.C., Rawlinson, W.D., Enhanced diagnosis of pandemic (H1N1) 2009 influenza infection using molecular and serological testing in intensive care unit patients with suspected influenza (2010) Clin Infect Dis, 51, pp. 70-72; Booth, C.M., Stewart, T.E., Severe acute respiratory syndrome and critical care medicine: the Toronto experience (2005) Crit Care Med, 33, pp. S53-S60; Hick, J.L., Einav, S., Hanfling, D., Kissoon, N., Dichter, J.R., Devereaux, A.V., Christian, M.D., Surge capacity principles: care of the critically ill and injured during pandemics and disasters: CHEST consensus statement (2014) Chest, 146, pp. e1S-e16S; Shalhoub, S., Al-Hameed, F., Mandourah, Y., Balkhy, H.H., Al-Omari, A., Al Mekhlafi, G.A., Kharaba, A., Arabi, Y.M., Critically ill healthcare workers with the Middle East respiratory syndrome (MERS): a multicenter study (2018) PLoS ONE, 13; Infection Prevention and Control during Health Care When Novel Coronavirus (Ncov) Infection is Suspected, , https://www.who.int/publications-detail/infection-prevention-and-control-during-health-care-when-novel-coronavirus-(ncov)-infection-is-suspected-20200125, Accessed 2 Mar 2020; Almutairi, A.F., Adlan, A.A., Balkhy, H.H., Abbas, O.A., Clark, A.M., ""It feels like I'm the dirtiest person in the world."": Exploring the experiences of healthcare providers who survived MERS-CoV in Saudi Arabia (2018) J Infect Public Health, 11, pp. 187-191; Lurie, N., Manolio, T., Patterson, A.P., Collins, F., Frieden, T., Research as a part of public health emergency response (2013) N Engl J Med, 368, pp. 1251-1255. , COI: 1:CAS:528:DC%2BC3sXlt1Sqs7s%3D; Adaptive platform trials: definition, design, conduct and reporting considerations (2019) Nat Rev Drug Discov, 18, pp. 797-807; Fowler, R.A., Lapinsky, S.E., Hallett, D., Detsky, A.S., Sibbald, W.J., Slutsky, A.S., Stewart, T.E., Toronto, S.C.C.G., Critically ill patients with severe acute respiratory syndrome (2003) JAMA, 290, pp. 367-373","Arabi, Y.M.; Intensive Care Department, Ministry of National Guard Health AffairsSaudi Arabia; email: arabi@ngha.med.sa",,Springer,3424642,,ICMED,32125458,English,Intensive Care Med.,Article,Article in Press,Open Access,Scopus,2-s2.0-85081601171,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Ong S.W.X., Tan Y.K., Chia P.Y., Lee T.H., Ng O.T., Wong M.S.Y., Marimuthu K.",57201670058;57215661242;57193889680;57215659165;57203665233;37021114600;55533856400;,"Air, Surface Environmental, and Personal Protective Equipment Contamination by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) from a Symptomatic Patient",2020,JAMA - Journal of the American Medical Association,,,,,,,6,10.1001/jama.2020.3227,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081587880&doi=10.1001%2fjama.2020.3227&partnerID=40&md5=1a29fc03a58afb39be9f9af01dbac59a,"National Centre for Infectious Diseases, 16 Jalan Tan Tock Seng, Singapore, 308442, Singapore; DSO National Laboratories, Singapore, Singapore","Ong, S.W.X., National Centre for Infectious Diseases, 16 Jalan Tan Tock Seng, Singapore, 308442, Singapore; Tan, Y.K., DSO National Laboratories, Singapore, Singapore; Chia, P.Y., National Centre for Infectious Diseases, 16 Jalan Tan Tock Seng, Singapore, 308442, Singapore; Lee, T.H., National Centre for Infectious Diseases, 16 Jalan Tan Tock Seng, Singapore, 308442, Singapore; Ng, O.T., National Centre for Infectious Diseases, 16 Jalan Tan Tock Seng, Singapore, 308442, Singapore; Wong, M.S.Y., DSO National Laboratories, Singapore, Singapore; Marimuthu, K., National Centre for Infectious Diseases, 16 Jalan Tan Tock Seng, Singapore, 308442, Singapore",[No abstract available],,,"Chowell, G., Abdirizak, F., Lee, S., Transmission characteristics of MERS and SARS in the healthcare setting: A comparative study (2015) BMC Med, 13, p. 210. , http://dx.doi.org/10.1186/s12916-015-0450-0, doi: PMID 26336062; Bin, S.Y., Heo, J.Y., Song, M.S., Environmental contamination and viral shedding in MERS patients during MERS-CoV outbreak in South Korea (2016) Clin Infect Dis, 62 (6), pp. 755-760. , http://dx.doi.org/10.1093/cid/civ1020, doi: PMID 26679623; Wang, D., Hu, B., Hu, C., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China JAMA, , http://jamanetwork.com/article.aspx?doi=10.1001/jama.2020.1585, Published online February 7, 2020. doi: PMID 32031570; Corman, V.M., Landt, O., Kaiser, M., Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR (2020) Euro Surveill, 25 (3). , http://dx.doi.org/10.2807/1560-7917.ES.2020.25.3.2000045, doi: PMID 31992387; Young, B., Ong, S.W.X., Kalimuddin, S., Epidemiologic features and clinical course of patients infected with SARS-CoV-2 in Singapore JAMA, , http://jamanetwork.com/article.aspx?doi=10.1001/jama.2020.3204, Published online March 3, 2020","Marimuthu, K.; National Centre for Infectious Diseases, 16 Jalan Tan Tock Seng, Singapore; email: kalisvar_marimuthu@ncid.sg",,American Medical Association,987484,,JAMAA,32129805,English,JAMA,Letter,Article in Press,Open Access,Scopus,2-s2.0-85081587880,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Huh S.,57215656875;,How to train the health personnel for protecting themselves from novel coronavirus (COVID-19) infection during their patient or suspected case care,2020,Journal of educational evaluation for health professions,17,,,10,,,,10.3352/jeehp.2020.17.10,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081584835&doi=10.3352%2fjeehp.2020.17.10&partnerID=40&md5=83712c93042020409dd92cf126909092,"Department of Parasitology and Institute of Medical Education, College of Medicine, Hallym University, Chuncheon, South Korea","Huh, S., Department of Parasitology and Institute of Medical Education, College of Medicine, Hallym University, Chuncheon, South Korea",[No abstract available],,"COVID-19; severe acute respiratory syndrome coronavirus 2; anamnesis; Betacoronavirus; Coronavirus infection; disease transmission; education; hand disinfection; health care personnel; human; infection control; mass screening; patient isolation; prevention and control; procedures; protective equipment; South Korea; virus pneumonia; Betacoronavirus; Coronavirus Infections; Hand Disinfection; Health Personnel; Humans; Infection Control; Infectious Disease Transmission, Patient-to-Professional; Mass Screening; Medical History Taking; Patient Isolation; Personal Protective Equipment; Pneumonia, Viral; Republic of Korea",,,,NLM (Medline),19755937,,,32150796,English,J Educ Eval Health Prof,Editorial,Final,Open Access,Scopus,2-s2.0-85081584835,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Khan Z., Muhammad K., Ahmed A., Rahman H.",57206025736;57215204300;57214310094;57210525068;,Coronavirus outbreaks: prevention and management recommendations,2020,Drugs and Therapy Perspectives,,,,,,,,10.1007/s40267-020-00717-x,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081574458&doi=10.1007%2fs40267-020-00717-x&partnerID=40&md5=c54a7ce10c190be8f83239facd94e1ca,"Department of Pharmacology (Pharmacovigilance), Institute of Health Sciences, Cukurova University, Adana, Turkey; Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan; Department of Pharmacy, Comsat University (Abbottabad Campus), Abbottabad, Pakistan; School of Pharmacy, Monash University, Subang Jaya, Selangor, Malaysia; Department of Microbiology, Abdul Wali Khan University Mardan (AWKUM), Mardan, Pakistan","Khan, Z., Department of Pharmacology (Pharmacovigilance), Institute of Health Sciences, Cukurova University, Adana, Turkey, Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan; Muhammad, K., Department of Pharmacy, Comsat University (Abbottabad Campus), Abbottabad, Pakistan; Ahmed, A., School of Pharmacy, Monash University, Subang Jaya, Selangor, Malaysia; Rahman, H., Department of Microbiology, Abdul Wali Khan University Mardan (AWKUM), Mardan, Pakistan",[No abstract available],,,"Coronavirus, , https://www.who.int/health-topics/coronavirus, Available from, Accessed 13 Feb 2020; Severe Acute Respiratory Syndrome, , https://www.cdc.gov/sars/index.html, Available from, Accessed 13 Feb 2020; (2020) Coronavirus Symptoms and Diagnosis, , https://www.cdc.gov/coronavirus/about/symptoms.html, Accessed 15 Feb; (2020) Coronavirus Disease 2019 (COVID-19) Situation Report: 24., , https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200213-sitrep-24-covid-19.pdf, Accessed 14 Feb; Wang, C., Horby, P.W., Hayden, F.G., A novel coronavirus outbreak of global health concern (2020) Lancet, 395 (10223), pp. 470-473; Novel Coronavirus (2019-Ncov) Situation Report:21, , https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200210-sitrep-21-ncov.pdf?sfvrsn=947679ef_2, Available from, Accessed 14 Feb 2020; 2019-Ncov Global Cases by John Hopkins CSSE, , https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6, Available from, Accessed 15 Feb 2020; Coronavirus Disease (COVID-19) Outbreak, , https://www.who.int/emergencies/diseases/novel-coronavirus-2019, Available from, Accessed 15 Feb 2020; Novel Coronavirus (2019-Ncov) Situation Report: 8, , https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200128-sitrep-8-ncov-cleared.pdf?sfvrsn=8b671ce5_2, Available from, Accessed 15 Feb 2020; Prevention, Treatment of Novel Coronavirus (2019-Ncov), , https://www.cdc.gov/coronavirus/2019-ncov/about/prevention-treatment.html, Available from, Date accessed: 16 Feb 2020; How are Coronavirus Patients Treated?, , https://www.bbc.com/news/world-asia-china-51295415, Available from, Accessed 16 Feb 2020; Patel, A., Jernigan, D.B., Initial Public Health Response and Interim Clinical Guidance for the 2019 Novel Coronavirus Outbreak: United States, , https://www.cdc.gov/mmwr/volumes/69/wr/mm6905e1.htm, Available from, Accessed 14 Feb 2020; Novel Coronavirus 2019 Situation Summary, Wuhan, China, , https://www.cdc.gov/coronavirus/2019-nCoV/summary.html, Available from, Accessed 16 Feb 2020; Statement on the Second Meeting of the International Health Regulations (2005) Emergency Committee regarding the Outbreak of Novel Coronavirus (2019-Ncov), , https://www.who.int/news-room/detail/30-01-2020-statement-on-the-second-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-outbreak-of-novel-coronavirus-(2019-ncov), Available from, Accessed 16 Feb 2020; Novel Coronavirus (2019-Ncov) Advice for the Public, , https://www.who.int/emergencies/diseases/novel-coronavirus-2019/advice-for-public, Available from, Accessed 17 Feb 2020; (2020) Updated WHO Advice for International Traffic in Relation to the Outbreak of the Novel Coronavirus 2019-Ncov, , https://www.who.int/ith/2020-27-01-outbreak-of-Pneumonia-caused-by-new-coronavirus/en/, Available from, Accessed 13 Feb; Coronavirus 2019-nCoV outbreak: Information and interim guidelines for pharmacists and the pharmacy workforce, , https://www.fip.org/file/4413, Available from, Accessed 17 Feb 2020","Muhammad, K.; Department of Pharmacy, Comsat University (Abbottabad Campus)Pakistan; email: khayal866@gmail.com",,Adis,11720360,,DTHPE,,English,Drugs Ther. Perspect.,Letter,Article in Press,Open Access,Scopus,2-s2.0-85081574458,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Cheng A.C., Williamson D.A.",57202414600;35265417600;,An outbreak of COVID-19 caused by a new coronavirus: what we know so far,2020,Medical Journal of Australia,,,,,,,,10.5694/mja2.50530,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081568608&doi=10.5694%2fmja2.50530&partnerID=40&md5=91170ea2b21fbce1ed87ca98b0fc4e17,"Infection Prevention and Healthcare Epidemiology Unit, Alfred Health, Melbourne, VIC, Australia; Monash University, Melbourne, VIC, Australia; Microbiological Diagnostic Unit Public Health Laboratory, University of Melbourne, Melbourne, VIC, Australia; Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia","Cheng, A.C., Infection Prevention and Healthcare Epidemiology Unit, Alfred Health, Melbourne, VIC, Australia, Monash University, Melbourne, VIC, Australia; Williamson, D.A., Microbiological Diagnostic Unit Public Health Laboratory, University of Melbourne, Melbourne, VIC, Australia, Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia",[No abstract available],"Disease transmission, infectious; Infectious diseases",,"Yin, Y., Wunderink, R.G., MERS, SARS and other coronaviruses as causes of pneumonia (2018) Respirology, 23, pp. 130-137; Chan, J.F., Lau, S.K., To, K.K., Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease (2015) Clin Microbiol Rev, 28, pp. 465-522; Stop the Wuhan virus [editorial] (2020) Nature, 577, p. 450; Wang, D., Hu, B., Hu, C., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) JAMA, , https://doi.org/10.1001/jama.2020.1585, [Epub ahead of print]; Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395, pp. 507-513; Li, Q., Guan, X., Wu, P., Wang, X., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med, , https://doi.org/10.1056/nejmo​a2001316, [Epub ahead of print]; Wu, J.T., Leung, K., Leung, G.M., Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study (2020) Lancet, , https://doi.org/10.1016/s0140-6736(20)30260-9, [Epub ahead of print]; Rothe, C., Schunk, M., Sothmann, P., Transmission of 2019-nCoV infection from an asymptomatic contact in Germany (2020) N Engl J Med, , https://doi.org/10.1056/nejmc​2001468, [Epub ahead of print]; Backer, J.A., Klinkenberg, D., Wallinga, J., Incubation period of 2019 novel coronavirus (2019-nCoV) infections among travellers from Wuhan, China, 20-28 January 2020 (2020) Eurosurveillance, 20. , pii=2000062; Stein, R.A., Super-spreaders in infectious diseases (2011) Int J Infect Dis, 15, pp. e510-513; (2020) Laboratory testing for 2019 novel coronavirus (2019-nCoV) in suspected human cases (Interim guidance, 17 January 2020), , https://www.who.int/publi​catio​ns-detai​l/labor​atory-testi​ng-for-2019-novel-coron​avirus-in-suspe​cted-human-cases-20200117, Geneva, WHO, (viewed Feb 2020); (2003) Learning from SARS: renewal of public health in Canada, , Ottawa, Government of Canada; Campbell, A., (2006) Commission to investigate the introduction and spread of SARS, Ontario. Spring of Fear, , Toronto, Ontario Ministry of Health and Long-Term Care","Cheng, A.C.; Infection Prevention and Healthcare Epidemiology Unit, Alfred HealthAustralia; email: allen.cheng@monash.edu",,John Wiley and Sons Inc.,0025729X,,MJAUA,32146721,English,Med. J. Aust.,Article,Article in Press,Open Access,Scopus,2-s2.0-85081568608,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Duan Y.-N., Qin J.",57215864115;57215863902;,Pre- And posttreatment chest CT findings: 2019 novel coronavirus (2019-NCoV) pneumonia,2020,Radiology,295,1,,21,,,3,10.1148/radiol.2020200323,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081562443&doi=10.1148%2fradiol.2020200323&partnerID=40&md5=bd7e21bfe2204a9eadf252250bb5f6d0,"Department of Radiology, Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Rd, Guangzhou, China","Duan, Y.-N., Department of Radiology, Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Rd, Guangzhou, China; Qin, J., Department of Radiology, Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Rd, Guangzhou, China",[No abstract available],,"interferon; COVID-19; interferon; severe acute respiratory syndrome coronavirus 2; adult; case report; China; clinical article; computer assisted tomography; coughing; disease duration; female; fever; fluorescence quantitative polymerase chain reaction; follow up; hospital admission; human; image analysis; lung lobe; middle aged; myalgia; nonhuman; Note; priority journal; SARS coronavirus; SARS coronavirus 2; SARS coronavirus 2 pneumonia; throat culture; travel; treatment duration; treatment outcome; virus pneumonia; Betacoronavirus; complication; Coronavirus infection; diagnostic imaging; fever; inhalational drug administration; isolation and purification; lung; pathology; real time polymerase chain reaction; virus pneumonia; x-ray computed tomography; Administration, Inhalation; Betacoronavirus; Coronavirus Infections; Female; Fever; Humans; Interferons; Lung; Middle Aged; Pneumonia, Viral; Real-Time Polymerase Chain Reaction; Tomography, X-Ray Computed","Lei, J., Li, J., Qi, X., CT imaging of the 2019 novel coronavirus (2019-NCoV) pneumonia Radiology, 2020. , https://doi.org/10.1148/radiol.2020200236, Published online January 30, 2020; Kanne, J., Chest CT findings in 2019-nCoV infections from Wuhan, China: What is currently known Radiology, 2020. , https://doi.org/10.1148/radiol.2020200241, Published online February 4, 2020","Qin, J.; Department of Radiology, Third Affiliated Hospital of Sun Yat-sen University, 600 Tianhe Rd, China; email: qinjie@mail.sysu.edu.cn",,Radiological Society of North America Inc.,338419,,RADLA,32049602,English,Radiology,Note,Final,Open Access,Scopus,2-s2.0-85081562443,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Yang H., Wang C., Poon L.C.",51765020700;57196394723;16033640200;,Novel coronavirus infection and pregnancy,2020,Ultrasound in Obstetrics and Gynecology,,,,,,,1,10.1002/uog.22006,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081561334&doi=10.1002%2fuog.22006&partnerID=40&md5=4ea948190296049b9784aaa88c734aa6,"Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China; Beijing Key Laboratory of Maternal Fetal Medicine of Gestational Diabetes Mellitus, Beijing, China; Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong","Yang, H., Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China, Beijing Key Laboratory of Maternal Fetal Medicine of Gestational Diabetes Mellitus, Beijing, China; Wang, C., Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China, Beijing Key Laboratory of Maternal Fetal Medicine of Gestational Diabetes Mellitus, Beijing, China; Poon, L.C., Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong",[No abstract available],,,"Coronavirus COVID-19 Global Cases, , https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6, Johns Hopkins CSSE, Accessed 1 March 2020; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Wu, W., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506; Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Wang, B., Peng, Z., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus infected pneumonia in Wuhan (2020) JAMA, , China; Guan, W., Ni, Z., Hu, Y., Liang, W., Ou, C., He, J., Liu, L., Chen, R., Clinical Characteristics of Coronavirus Disease 2019 in China (2020) N Engl J Med; (2020) New Coronavirus Pneumonia Prevention and Control Program (5Th Edn.) (In Chinese), , http://www.nhc.gov.cn/yzygj/s7653p/202002/d4b895337e19445f8d728fcaf1e3e13a/files/ab6bec7f93e64e7f998d802991203cd6.pdf; Siston, A.M., Rasmussen, S.A., Honein, M.A., Fry, A.M., Seib, K., Callaghan, W.M., Louie, J., Nielsen, C.F., Pandemic H1N1 Influenza in Pregnancy Working Group. Pandemic 2009 influenza A(H1N1) virus illness among pregnant women in the United States (2010) JAMA, 303, pp. 1517-1525; Wong, S.F., Chow, K.M., Leung, T.N., Ng, W.F., Ng, T.K., Shek, C.C., Ng, P.C., Tan, P.Y., Pregnancy and perinatal outcomes of women with severe acute respiratory syndrome (2004) Am J Obstet Gynecol, 191, pp. 292-297; Alfaraj, S.H., Al-Tawfiq, J.A., Memish, Z.A., Middle East respiratory syndrome coronavirus (MERS-CoV) infection during pregnancy: report of two cases & review of the literature (2019) J Microbiol Immunol Infect, 52, pp. 501-503; Chen, H., Guo, J., Wang, C., Luo, F., Yu, X., Zhang, W., Li, J., Zhang, Y., Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records (2020) Lancet, , https://doi.org/10.1016/S0140-6736(20)30360-3; Lei, D., Wang, C., Li, C., Fang, C., Yang, W., Cheng, B., Wei, M., Fan, C., Clinical characteristics of pregnancy with the 2019 novel coronavirus disease (COVID-19) infection (2020) Chin J Perinat Med, 23 (3); https://www.cdc.gov/coronavirus/2019-ncov/specific-groups/pregnancy-faq.html, Coronavirus Disease 2019 (COVID-19). Pregnant Women., [Accessed 1 March 2020]; Shek, C.C., Ng, P.C., Fung, G.P., Cheng, F.W., Chan, P.K., Peiris, M.J., Lee, K.H., Fok, T.F., Infants born to mothers with severe acute respiratory syndrome (2003) Pediatrics, 112; Zheng, Q.L., Duan, T., Jin, L.P., Single-cell RNA expression profiling of ACE2 and AXL in the human maternal–fetal interface (2020) Reprod Dev Med, , http://www.repdevmed.org/preprintarticle.asp?id=278679; Qi, H., Chen, D., Feng, L., Zou, L., Li, J., Obstetric considerations on delivery issues for pregnant women with COVID-19 infection (2020) Chin J Obstet Gynecol, 55, p. E001","Poon, L.C.; Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales HospitalHong Kong; email: liona.poon@cuhk.edu.hk",,John Wiley and Sons Ltd,9607692,,UOGYF,,English,Ultrasound Obstet. Gynecol.,Note,Article in Press,Open Access,Scopus,2-s2.0-85081561334,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Perrella A., Carannante N., Berretta M., Rinaldi M., Maturo N., Rinaldi L.",57215642539;6503962776;6604062299;35249160100;57215643512;40162120000;,Editorial - Novel Coronavirus 2019 (SARS-CoV2): A global emergency that needs new approaches?,2020,European Review for Medical and Pharmacological Sciences,24,4,,2162,2164,,,10.26355/eurrev_202002_20396,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081528717&doi=10.26355%2feurrev_202002_20396&partnerID=40&md5=f16001881f7aed6760af39f953f61372,"VII Division of Infectious Diseases and Immunology, P.O. “D. Cotugno”, AORN Ospedali dei Colli, Naples, Italy; Infectious Diseases Emergency Unit, P.O. “D. Cotugno”, AORN Ospedali dei Colli, Naples, Italy; Department of Medical Oncology, Istituto Nazionale Tumori, CRO AvianoPN, Italy; Department Multidisciplinary Department of Medical, Surgical and Dental Specialties, University of Campania “Luigi Vanvitelli”, Naples, Italy; Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Naples, Italy","Perrella, A., VII Division of Infectious Diseases and Immunology, P.O. “D. Cotugno”, AORN Ospedali dei Colli, Naples, Italy; Carannante, N., Infectious Diseases Emergency Unit, P.O. “D. Cotugno”, AORN Ospedali dei Colli, Naples, Italy; Berretta, M., Department of Medical Oncology, Istituto Nazionale Tumori, CRO AvianoPN, Italy; Rinaldi, M., Department Multidisciplinary Department of Medical, Surgical and Dental Specialties, University of Campania “Luigi Vanvitelli”, Naples, Italy; Maturo, N., Infectious Diseases Emergency Unit, P.O. “D. Cotugno”, AORN Ospedali dei Colli, Naples, Italy; Rinaldi, L., Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”, Naples, Italy",[No abstract available],,artificial intelligence; China; Coronavirinae; disease control; disease course; disease transmission; Editorial; emergency; epidemic; forecasting; machine learning; prediction; public health; severe acute respiratory syndrome coronavirus 2; tertiary care center; time series analysis; trend study; World Health Organization,"Undiagnosed Pneumonia - China (HU): Request for Information, , https://promedmail.org/promed-post/?id=6864153, Pro-MED. PRO/AH/EDR. Archive Number: 20191230.6864153. 30 Dec 2019. 23:59; https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6; https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports/; Cowling, B.J., Leung, G.M., Epidemiological research priorities for public health control of the ongoing global novel coronavirus (2019-nCoV) outbreak Euro Surveill, 2020, p. 25; Wiens, J., Shenoy, E.S., Machine learning for healthcare: On the verge of a major shift in healthcare epidemiology (2018) Clin Infect Dis, 66, pp. 149-153; Weinstein, R.A., Planning for epidemics-the lessons of SARS (2004) N Engl J Med, 350, pp. 2332-2334; Rawson, T.M., Hernandez, B., Moore, L.S.P., Blandy, O., Herrero, P., Gilchrist, M., Gordon, A., Holmes, A.H., Supervised machine learning for the prediction of infection on admission to hospital: A prospective observational cohort study (2019) J Antimicrob Chemother, 74, pp. 1108-1115; Berglund, J., AI tackles hospital infections: Machine learning is helping clinicians (2018) IEEE Pulse, 9, pp. 4-7; Liu, K., Cai, J., Wang, S., Wu, Z., Li, L., Jiang, T., Chen, B., Jiang, J., Identification of distribution characteristics and epidemic trends of hepatitis E in Zhejiang province, China from 2007 to 2012 (2016) Sci Rep, 6, p. 25407; Guo, P., Liu, T., Zhang, Q., Wang, L., Xiao, J., Zhang, Q., Luo, G., Ma, W., Developing a dengue forecast model using machine learning: A case study in China (2017) PLoS Negl Trop Dis, 11; Guan, P., Wu, W., Huang, D., Trends of reported human brucellosis cases in mainland China from 2007 to 2017: An exponential smoothing time series analysis (2018) Environ Health Prev Med, 23, p. 23; http://www.salute.gov.it/portale/nuovocoronavirus/dettaglioContenutiNuovoCoronavirus.jsp?lingua=italiano&id=5338&area=nuovoCoronavirus&menu=vuoto","Rinaldi, L.; Department of Advanced Medical and Surgical Sciences, University of Campania “Luigi Vanvitelli”Italy; email: lucarinaldi@hotmail.it",,Verduci Editore s.r.l,11283602,,RESFD,32141586,English,Eur. Rev. Med. Pharmacol. Sci.,Editorial,Final,,Scopus,2-s2.0-85081528717,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Kanne J.P.,57201959724;,"Chest CT findings in 2019 novel coronavirus (2019-NCoV) infections from Wuhan, China: Key points for the radiologist",2020,Radiology,295,1,,16,17,,9,10.1148/radiol.2020200241,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081409326&doi=10.1148%2fradiol.2020200241&partnerID=40&md5=4630dba4c07862e1fb1756a0bcac66ff,"Department of Radiology, University of Wisconsin-Madison School of Medicine and Public Health, 600 Highland Ave, Madison, WI 53792, United States","Kanne, J.P., Department of Radiology, University of Wisconsin-Madison School of Medicine and Public Health, 600 Highland Ave, Madison, WI 53792, United States",[No abstract available],,"COVID-19; severe acute respiratory syndrome coronavirus 2; adult; anamnesis; Betacoronavirus; child; complication; Coronavirus infection; diagnostic imaging; disease exacerbation; human; lung; pathogenicity; pathology; radiologist; severe acute respiratory syndrome; thorax radiography; travel; virus pneumonia; x-ray computed tomography; Adult; Betacoronavirus; Child; Coronavirus Infections; Disease Progression; Humans; Lung; Medical History Taking; Pneumonia, Viral; Radiography, Thoracic; Radiologists; Severe Acute Respiratory Syndrome; Tomography, X-Ray Computed; Travel","(2019) Report of Clustering Pneumonia of Unknown Etiology in Wuhan City, , Wuhan, China: Wuhan Municipal Health Commission; Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 N Engl J Med, , Published online January 25, 2020; (2019) Novel Coronavirus (2019-nCoV) in the U.S, , https://www.cdc.gov/coronavirus/2019-ncov/cases-in-us.html, Centers for Disease Control and Prevention Updated February 3, 2020; Novel Coronavirus (2019-nCoV) Situation Report 7, p. 2020. , Geneva, Switzerland: World Health Organization. Published online January 27; Su, S., Wong, G., Shi, W., Epidemiology, genetic recombination, and pathogenesis of coronaviruses (2016) Trends Microbiol, 24 (6), pp. 490-502; Cui, J., Li, F., Shi, Z.L., Origin and evolution of pathogenic coronaviruses (2019) Nat Rev Microbiol, 17 (3), pp. 181-192; Chan, J.F., Yuan, S., Kok, K.H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: A study of a family cluster Lancet, , Published online January 28, 2020; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Lancet, , Published online January 28, 2020; Lei, J., Li, J., Xiaolong, Q., CT imaging of the 2019 novel coronavirus (2019-NCoV) pneumonia Radiology, , https://doi.org/10.1148/radiol.2020200236, Published online January 31, 2020; Chung, M., Bernheim, A., Mei, X., CT imaging features of 2019 novel coronavirus (2019-nCoV) Radiology, , press; Muller, N.L., Ooi, G.C., Khong, P.L., Zhou, L.J., Tsang, K.W., Nicolaou, S., High-resolution CT findings of severe acute respiratory syndrome at presentation and after admission (2004) AJR Am J Roentgenol, 182 (1), pp. 39-44; Nicolaou, S., Al-Nakshabandi, N.A., Muller, N.L., SARS: Imaging of severe acute respiratory syndrome (2003) AJR Am J Roentgenol, 180 (5), pp. 1247-1249; Ooi, G.C., Khong, P.L., Muller, N.L., Severe acute respiratory syndrome: Temporal lung changes at thin-section CT in 30 patients (2004) Radiology, 230 (3), pp. 836-844; Das, K.M., Lee, E.Y., Al Jawder, S.E., Acute Middle East respiratory syndrome coronavirus: Temporal lung changes observed on the chest radiographs of 55 patients (2015) AJR Am J Roentgenol, 205 (3), pp. W267-W274; Das, K.M., Lee, E.Y., Enani, M.A., CT correlation with outcomes in 15 patients with acute Middle East respiratory syndrome coronavirus (2015) AJR Am J Roentgenol, 204 (4), pp. 736-742; Desai, S.R., Wells, A.U., Rubens, M.B., Evans, T.W., Hansell, D.M., Acute respiratory distress syndrome: CT abnormalities at long-term follow-up (1999) Radiology, 210 (1), pp. 29-35; Desai, S.R., Acute respiratory distress syndrome: Imaging of the injured lung (2002) Clin Radiol, 57 (1), pp. 8-17","Kanne, J.P.; Department of Radiology, University of Wisconsin-Madison School of Medicine and Public Health, 600 Highland Ave, United States; email: jkanne@uwhealth.org",,Radiological Society of North America Inc.,338419,,RADLA,32017662,English,Radiology,Review,Final,Open Access,Scopus,2-s2.0-85081409326,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Garnier-Crussard A., Forestier E., Gilbert T., Krolak-Salmon P.",56530676700;13008518000;57215605411;6603941705;,Novel Coronavirus (COVID-19) Epidemic: What Are the Risks for Older Patients?,2020,Journal of the American Geriatrics Society,,,,,,,,10.1111/jgs.16407,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081382200&doi=10.1111%2fjgs.16407&partnerID=40&md5=d28b1100c16041ac4d7e82160cffc94f,"Institut du Vieillissement I-Vie, Hospices Civils de Lyon, Lyon, France; Centre Mémoire Ressource et Recherche de Lyon, Hospices Civils de Lyon, Lyon, France; Service de Maladies Infectieuses, Centre Hospitalier Métropole Savoie, Chambéry, France; Health Services and Performance Research (HESPER EA7425), Lyon, France; Centre de Recherche Clinique CRC-VCF (Vieillissement-Cerveau-Fragilité), Hôpital des Charpennes, Hospices Civils de Lyon, Lyon, France","Garnier-Crussard, A., Institut du Vieillissement I-Vie, Hospices Civils de Lyon, Lyon, France, Centre Mémoire Ressource et Recherche de Lyon, Hospices Civils de Lyon, Lyon, France; Forestier, E., Service de Maladies Infectieuses, Centre Hospitalier Métropole Savoie, Chambéry, France; Gilbert, T., Institut du Vieillissement I-Vie, Hospices Civils de Lyon, Lyon, France, Centre Mémoire Ressource et Recherche de Lyon, Hospices Civils de Lyon, Lyon, France, Health Services and Performance Research (HESPER EA7425), Lyon, France; Krolak-Salmon, P., Institut du Vieillissement I-Vie, Hospices Civils de Lyon, Lyon, France, Centre Mémoire Ressource et Recherche de Lyon, Hospices Civils de Lyon, Lyon, France, Centre de Recherche Clinique CRC-VCF (Vieillissement-Cerveau-Fragilité), Hôpital des Charpennes, Hospices Civils de Lyon, Lyon, France",[No abstract available],,,"(2020), https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200304-sitrep-44-covid-19.pdf?sfvrsn=783b4c9d_2.&ZeroWidthSpace, 2019 (COVID-19). Situation report—44., Accessed March 5, 2020; Zumla, A., Hui, D.S., Perlman, S., Middle East respiratory syndrome (2015) Lancet, 386, pp. 995-1007; Chan-Yeung, M., Xu, R.-H., SARS: epidemiology (2003) Respirology, 8, pp. S9-S14; Wang, D., Hu, B., Hu, C., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China (2020) JAMA, , https://jamanetwork.com/journals/jama/fullarticle/2761044, Accessed February 9, 2020; Wang, W., Tang, J., Wei, F., Updated understanding of the outbreak of 2019 novel coronavirus (2019-nCoV) in Wuhan, China (2020) J Med Virol, 92, pp. 441-447. , https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.25689, Accessed February 10, 2020; Mahase, E., China coronavirus: what do we know so far? (2020) BMJ, 368. , m308; Thompson, W.W., Shay, D.K., Weintraub, E., Mortality associated with influenza and respiratory syncytial virus in the United States (2003) JAMA, 289, pp. 179-186; Ferrucci, L., Guralnik, J.M., Pahor, M., Corti, M.C., Havlik, R.J., Hospital diagnoses, Medicare charges, and nursing home admissions in the year when older persons become severely disabled (1997) JAMA, 277, pp. 728-734; (2020), https://www.who.int/docs/default-source/documents/advice-on-the-use-of-masks-2019-ncov.pdf, WHO. Advice on the use of masks in the community, during home care and in health care settings in the context of the novel coronavirus (2019-nCoV) outbreak Interim Guidance., Accessed February 14, 2020; (2020), https://www.cdc.gov/coronavirus/2019-ncov/about/prevention-treatment.html, Centers for Disease Control and Prevention. 2019-nCoV Prevention & Treatment., Accessed February 12, 2020","Garnier-Crussard, A.; Institut du Vieillissement I-Vie, Hospices Civils de LyonFrance; email: antoine.garnier-crussard@chu-lyon.fr",,Blackwell Publishing Inc.,28614,,JAGSA,,English,J. Am. Geriatr. Soc.,Letter,Article in Press,Open Access,Scopus,2-s2.0-85081382200,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Lei J., Li J., Li X., Qi X.",57215863980;57215864173;57211825414;55753297300;,CT imaging of the 2019 novel coronavirus (2019-NCoV) pneumonia,2020,Radiology,295,1,,18,,,14,10.1148/radiol.2020200236,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081380710&doi=10.1148%2fradiol.2020200236&partnerID=40&md5=4b79a096f434acdf36165d80c8a4a66f,"2019-nCoV Investigating and Research Team, First Hospital of Lanzhou University, 1 Donggang West Rd, Lanzhou, 730000, China","Lei, J., 2019-nCoV Investigating and Research Team, First Hospital of Lanzhou University, 1 Donggang West Rd, Lanzhou, 730000, China; Li, J., 2019-nCoV Investigating and Research Team, First Hospital of Lanzhou University, 1 Donggang West Rd, Lanzhou, 730000, China; Li, X., 2019-nCoV Investigating and Research Team, First Hospital of Lanzhou University, 1 Donggang West Rd, Lanzhou, 730000, China; Qi, X., 2019-nCoV Investigating and Research Team, First Hospital of Lanzhou University, 1 Donggang West Rd, Lanzhou, 730000, China",[No abstract available],,"C reactive protein; D dimer; interferon; biological marker; COVID-19; abnormal respiratory sound; adult; body temperature; case report; China; clinical article; clinical feature; computer assisted tomography; coronavirus disease 2019; coronavirus disease 2019; Coronavirus infection; coughing; disease exacerbation; eosinophil; erythrocyte sedimentation rate; female; fever; human; leukopenia; neutrophil; Note; priority journal; real time polymerase chain reaction; sputum analysis; virus pneumonia; complication; Coronavirus infection; coughing; diagnostic imaging; fever; lung; metabolism; pathology; travel; virus pneumonia; x-ray computed tomography; Adult; Biomarkers; China; Coronavirus Infections; Cough; Female; Fever; Humans; Lung; Pneumonia, Viral; Respiratory Sounds; Tomography, X-Ray Computed; Travel","Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 N Engl J Med, 2020, p. 24. , Jan Epub ahead of print; Munster, V.J., Koopmans, M., van Doremalen, N., van Riel, D., de Wit, E., A novel coronavirus emerging in China - Key questions for impact assessment N Engl J Med, 2020. , Jan 24.: Epub ahead of print","Qi, X.; 2019-nCoV Investigating and Research Team, First Hospital of Lanzhou University, 1 Donggang West Rd, China; email: qixiaolong@vip.163.com",,Radiological Society of North America Inc.,338419,,RADLA,32003646,English,Radiology,Note,Final,Open Access,Scopus,2-s2.0-85081380710,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Liu P., Tan X.-Z.",57208413592;56978574700;,2019 Novel coronavirus (2019-NCoV) pneumonia,2020,Radiology,295,1,,19,,,3,10.1148/radiol.2020200257,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081326614&doi=10.1148%2fradiol.2020200257&partnerID=40&md5=6b63bbcbfbd3e4a8f1408da6c092da88,"Department of Radiology, Hunan Provincial People’s Hospital, Hunan Normal University, Changsha, 410005, China","Liu, P., Department of Radiology, Hunan Provincial People’s Hospital, Hunan Normal University, Changsha, 410005, China; Tan, X.-Z., Department of Radiology, Hunan Provincial People’s Hospital, Hunan Normal University, Changsha, 410005, China",[No abstract available],,"adult; case report; China; clinical article; disease duration; female; fever; human; image analysis; image reconstruction; nonhuman; Note; patient isolation; patient monitoring; priority journal; real time polymerase chain reaction; SARS coronavirus; SARS coronavirus 2; SARS coronavirus 2 pneumonia; throat culture; travel; virus pneumonia; x-ray computed tomography; Betacoronavirus; complication; Coronavirus infection; diagnostic imaging; fever; isolation and purification; lung; pathology; thorax radiography; virus pneumonia; x-ray computed tomography; COVID-19; severe acute respiratory syndrome coronavirus 2; Adult; Betacoronavirus; Coronavirus Infections; Female; Fever; Humans; Lung; Pneumonia, Viral; Radiography, Thoracic; Real-Time Polymerase Chain Reaction; Tomography, X-Ray Computed","Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 N Engl J Med, 2020. , Epub ahead of print; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Lancet, 2020. , Epub ahead of print; Lei, J., Li, J., Qi, X., CT imaging of the 2019 novel coronavirus (2019-NCoV) pneumonia Radiology, 2020. , press; Kanne, J., Chest CT findings found in 2019-nCoV infections from Wuhan, China: What is currently known Radiology, , press; Chung, M., Bernheim, A., Mei, X., CT imaging features of 2019 novel coronavirus (2019-nCoV) Radiology, , press","Tan, X.-Z.; Department of Radiology, Hunan Provincial People’s Hospital, Hunan Normal UniversityChina; email: xianzhengtan@163.com",,Radiological Society of North America Inc.,338419,,RADLA,32013795,English,Radiology,Note,Final,Open Access,Scopus,2-s2.0-85081326614,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Rello J., Tejada S., Userovici C., Arvaniti K., Pugin J., Waterer G.",55651028100;57210075450;57215587244;6602798493;57206228584;7004316792;,Coronavirus Disease 2019 (COVID-19): A critical care perspective beyond China,2020,Anaesthesia Critical Care and Pain Medicine,,,,,,,,10.1016/j.accpm.2020.03.001,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081281123&doi=10.1016%2fj.accpm.2020.03.001&partnerID=40&md5=86e8a35a78b9aa025dabd5d915937e40,"Centro de Investigación Biomedica en Red de Enfermedades Respiratorias (CIBERES), Instituto Salud Carlos III, Madrid, Spain; Clinical Research/Epidemiology in Pneumonia and Sepsis (CRIPS), Vall d'Hebron Institut of Research (VHIR), Barcelona, Spain; Anaesthesiology and Critical Care Division, CHU Nîmes, University Montpellier-Nîmes, Nîmes, France; Département Anesthésie Réanimation, Hôpital Pitié-Salpêtrière, Paris, France; Junior Group of the French Society of Anaesthesia and Intensive Care Medicine (SFAR), Paris, France; Critical Care Department, General Hospital Papageorgiou, Thessaloniki, Greece; Division of Intensive Care, University Hospitals of Geneva, Geneva, Switzerland; School of Medicine, University of Western Australia, Perth, Australia","Rello, J., Centro de Investigación Biomedica en Red de Enfermedades Respiratorias (CIBERES), Instituto Salud Carlos III, Madrid, Spain, Clinical Research/Epidemiology in Pneumonia and Sepsis (CRIPS), Vall d'Hebron Institut of Research (VHIR), Barcelona, Spain, Anaesthesiology and Critical Care Division, CHU Nîmes, University Montpellier-Nîmes, Nîmes, France; Tejada, S., Centro de Investigación Biomedica en Red de Enfermedades Respiratorias (CIBERES), Instituto Salud Carlos III, Madrid, Spain, Clinical Research/Epidemiology in Pneumonia and Sepsis (CRIPS), Vall d'Hebron Institut of Research (VHIR), Barcelona, Spain; Userovici, C., Département Anesthésie Réanimation, Hôpital Pitié-Salpêtrière, Paris, France, Junior Group of the French Society of Anaesthesia and Intensive Care Medicine (SFAR), Paris, France; Arvaniti, K., Critical Care Department, General Hospital Papageorgiou, Thessaloniki, Greece; Pugin, J., Division of Intensive Care, University Hospitals of Geneva, Geneva, Switzerland; Waterer, G., School of Medicine, University of Western Australia, Perth, Australia",[No abstract available],Coronavirus; Influenza; Intensive care medicine; Mechanical ventilation; Outbreak; Pneumonia; SARS-COV-2,,"Yang, X., Yu, Y., Xu, J., Shu, H., Xia, J., Liu, H., Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study (2020) Lancet Respir Med, , [Epub Ahead of print]; Rello, J., Rodríguez, A., Ibañez, P., Socias, L., Cebrian, J., Marques, A., Intensive care adult patients with severe respiratory failure caused by Influenza A (H1N1)v in Spain (2009) Crit Care, 13, p. R148; Novel Coronavirus Pneumonia Emergency Response Epidemiology Team., [The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China] (2020) Zhonghua Liu Xing Bing Xue Za Zhi, 41, pp. 145-151; Shang, L., Zhao, J., Hu, Y., Du, R., Cao, B., On the use of corticosteroids for 2019-nCoV pneumonia (2020) The Lancet, , [Epub Ahead of print]; Diaz, E., Martin-Loeches, I., Canadell, L., Vidaur, L., Suarez, D., Socias, L., Corticosteroid therapy in patients with primary viral pneumonia due to pandemic (H1N1) 2009 influenza (2012) J Infect, 64, pp. 311-318; Arabi, Y.M., Mandourah, Y., Al-Hameed, F., Sindi, A.A., Almekhlafi, G.A., Hussein, M.A., Corticosteroid therapy for critically ill patients with Middle East respiratory syndrome (2018) Am J Respir Crit Care Med, 197, pp. 757-767; Jansson, M., Liao, X., Rello, J., Strengthening ICU health security for a coronavirus epidemic (2020) Intensive Crit Care Nurs, p. 102812; Fang, Y., Zhang, H., Xie, J., Lin, M., Ying, L., Pang, P., Sensitivity of Chest CT for COVID-19: Comparison to RT-PCR (2020) Radiology, p. 200432. , [Epub Ahead of print]; Hirose, R., Nakaya, T., Naito, Y., Daidoji, T., Bandou, R., Inoue, K., Situations Leading to Reduced Effectiveness of Current Hand Hygiene against Infectious Mucus from Influenza Virus-Infected Patients (2019) mSphere, p. 4; Arabi, Y.M., Fowler, R., Hayden, F.G., Critical care management of adults with community-acquired severe respiratory viral infection (2020) Intensive Care Med, , [Epub Ahead of print]; Alraddadi, B.M., Qushmaq, I., Al-Hameed, F.M., Mandourah, Y., Almekhlafi, G.A., Jose, J., Noninvasive ventilation in critically ill patients with the Middle East respiratory syndrome (2019) Influenza Other Respir Viruses, 13, pp. 382-390; Hui, D., Yan, F., Chen, R.-H., The effects of azithromycin on patients with diffuse panbronchiolitis: a retrospective study of 29 cases (2013) J Thorac Dis, 5, pp. 613-617; McCracken, J., Should noninvasive ventilation be considered a high-risk procedure during an epidemic? (2009) CMAJ, 181, pp. 663-664; Rello, J., Pérez, M., Roca, O., Poulakou, G., Souto, J., Laborda, C., High-flow nasal therapy in adults with severe acute respiratory infection: a cohort study in patients with 2009 influenza A/H1N1 v (2012) J Crit Care, 27, pp. 434-439","Rello, J.; Vall d'Hebron Institut de Recerca, Ps Vall d'Hebron 119 AMI-14th floor, Spain; email: jrello@crips.es",,Elsevier Masson SAS,23525568,,,32142972,English,Anaesth. Crit. Care Pain Med.,Editorial,Article in Press,Open Access,Scopus,2-s2.0-85081281123,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Joob B., Wiwanitkit V.",53663749900;55628572491;,Frequency of arrhythmia in novel coronavirus 2019 infection,2020,Journal of Arrhythmia,,,,,,,,10.1002/joa3.12330,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081276787&doi=10.1002%2fjoa3.12330&partnerID=40&md5=becf6dc180fc87a8b5cf8502bba92e74,"Sanitation1 Medical Academic Center, Bangkok, Thailand; Department of Community Medicine, Dr DY Patil University, Pune, India; Department of Tropical Medicine, Hainan Medical University, Haikou, China","Joob, B., Sanitation1 Medical Academic Center, Bangkok, Thailand; Wiwanitkit, V., Department of Community Medicine, Dr DY Patil University, Pune, India, Department of Tropical Medicine, Hainan Medical University, Haikou, China",[No abstract available],arrhythmia; cardiac; coronavirus; frequency; infection,,"Hsia, W., Emerging new coronavirus infection in Wuhan, China: situation in early 2020 (2020) Case Study Case Rep, 10, pp. 8-9; Liu, K., Fang, Y.-Y., Deng, Y., Liu, W., Wang, M.-F., Ma, J.-P., Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province (2020) Chin Med J (Engl), , https://doi.org/10.1097/CM9.0000000000000744, [Epub ahead of print]; Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) JAMA, , https://doi.org/10.1001/jama.2020.1585, [Epub ahead of print]; Chen, L., Liu, H.G., Liu, W., Liu, J., Liu, K., Shang, J., Analysis of clinical features of 29 patients with 2019 novel coronavirus pneumonia (2020) Zhonghua Jie He He Hu Xi Za Zhi, 43. , https://doi.org/10.3760/cma.j.issn.1001-0939.2020.0005, [Epub ahead of print]","Joob, B.; Sanitation1 Medical Academic CenterThailand; email: beuyjoob@hotmail.com",,Wiley-Blackwell,18804276,,,,English,J. Arrhythmia,Letter,Article in Press,Open Access,Scopus,2-s2.0-85081276787,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wu Z., McGoogan J.M.",7501412011;55578005000;,Characteristics of and Important Lessons from the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72314 Cases from the Chinese Center for Disease Control and Prevention,2020,JAMA - Journal of the American Medical Association,,,,,,,52,10.1001/jama.2020.2648,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081266700&doi=10.1001%2fjama.2020.2648&partnerID=40&md5=ab1d59d985f80ac12065a2099d21891e,"Chinese Center for Disease Control and Prevention, 155 Changbai Rd, Beijing, 102206, China","Wu, Z., Chinese Center for Disease Control and Prevention, 155 Changbai Rd, Beijing, 102206, China; McGoogan, J.M., Chinese Center for Disease Control and Prevention, 155 Changbai Rd, Beijing, 102206, China",[No abstract available],,,"Vital surveillances: The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19)-China, 2020 China CDC Weekly. Accessed February 20, 2020. http://weekly.chinacdc.cn/en/article/id/e53946e2-c6c4-41e9-9a9b-fea8db1a8f51; Battegay, M., Kuehl, R., Tschudin-Sutter, S., Hirsch, H.H., Widmer, A.F., Neher, R.A., 2019-Novel coronavirus (2019-nCoV): Estimating the case fatality rate: A word of caution (2020) Swiss Med Wkly, 150. , http://dx.doi.org/10.4414/smw.2020.20203, w20203. doi: PMID 32031234; McCloskey, B., Heymann, D.L., SARS to novel coronavirus: Old lessons and new lessons (2020) Epidemiol Infect, 148. , http://dx.doi.org/10.1017/S0950268820000254, e22. doi: PMID 32019614; Du, Z., Wang, L., Cauchemez, S., Risk for transportation of 2019 novel coronavirus disease from Wuhan to other cities in China (2020) Emerg Infect Dis, 26 (5). , http://dx.doi.org/10.3201/eid2605.200146; Wilder-Smith, A., Freedman, D.O., Isolation, quarantine, social distancing and community containment: Pivotal role for old-style public health measures in the novel coronavirus (2019-nCoV) outbreak (2020) J Travel Med, , http://dx.doi.org/10.1093/jtm/taaa020, taaa020. doi: PMID 32052841; Cowling, B.J., Leung, G.M., Epidemiological research priorities for public health control of the ongoing global novel coronavirus (2019-nCoV) outbreak (2020) Euro Surveill, 25 (6). , http://dx.doi.org/10.2807/1560-7917.ES.2020.25.6.2000110, PMID 32046814","Wu, Z.; Chinese Center for Disease Control and Prevention, 155 Changbai Rd, China; email: wuzy@263.net",,American Medical Association,987484,,JAMAA,32091533,English,JAMA,Article,Article in Press,Open Access,Scopus,2-s2.0-85081266700,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Gorbalenya A.E., Baker S.C., Baric R.S., de Groot R.J., Drosten C., Gulyaeva A.A., Haagmans B.L., Lauber C., Leontovich A.M., Neuman B.W., Penzar D., Perlman S., Poon L.L.M., Samborskiy D.V., Sidorov I.A., Sola I., Ziebuhr J., Coronaviridae Study Group of the International Committee on Taxonomy of Viruses",7005626044;7403307881;57205312930;7103077066;7003813990;56841599800;6701371301;57205045581;23985202000;8263558000;57200541433;57204567845;57216111018;35729042500;7005186545;7003336781;7003783935;,The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2,2020,Nature Microbiology,,,,,,,3,10.1038/s41564-020-0695-z,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081266636&doi=10.1038%2fs41564-020-0695-z&partnerID=40&md5=c3b90b29e9e51014a492edc9b240221e,"Department of Medical Microbiology, Leiden University Medical Center, Leiden, Netherlands; Faculty of Bioengineering and Bioinformatics and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russian Federation; Department of Microbiology and Immunology, Loyola University of Chicago, Stritch School of Medicine, Maywood, IL, United States; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, United States; Division of Virology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands; Institute of Virology, Charité – Universitätsmedizin Berlin, Berlin, Germany; Viroscience Lab, Erasmus MC, Rotterdam, Netherlands; Texas A&M University-Texarkana, Texarkana, TX, United States; Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, United States; Centre of Influenza Research & School of Public Health, The University of Hong Kong, Hong Kong; Department of Molecular and Cell Biology, National Center of Biotechnology (CNB-CSIC), Campus de Cantoblanco, Madrid, Spain; Institute of Medical Virology, Justus Liebig University Giessen, Giessen, Germany; Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands","Gorbalenya, A.E., Department of Medical Microbiology, Leiden University Medical Center, Leiden, Netherlands, Faculty of Bioengineering and Bioinformatics and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russian Federation, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands; Baker, S.C., Department of Microbiology and Immunology, Loyola University of Chicago, Stritch School of Medicine, Maywood, IL, United States; Baric, R.S., Department of Epidemiology, University of North Carolina, Chapel Hill, NC, United States; de Groot, R.J., Division of Virology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands; Drosten, C., Institute of Virology, Charité – Universitätsmedizin Berlin, Berlin, Germany; Gulyaeva, A.A., Department of Medical Microbiology, Leiden University Medical Center, Leiden, Netherlands; Haagmans, B.L., Viroscience Lab, Erasmus MC, Rotterdam, Netherlands; Lauber, C., Department of Medical Microbiology, Leiden University Medical Center, Leiden, Netherlands; Leontovich, A.M., Faculty of Bioengineering and Bioinformatics and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russian Federation; Neuman, B.W., Texas A&M University-Texarkana, Texarkana, TX, United States; Penzar, D., Faculty of Bioengineering and Bioinformatics and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russian Federation; Perlman, S., Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, United States; Poon, L.L.M., Centre of Influenza Research & School of Public Health, The University of Hong Kong, Hong Kong; Samborskiy, D.V., Faculty of Bioengineering and Bioinformatics and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russian Federation; Sidorov, I.A., Department of Medical Microbiology, Leiden University Medical Center, Leiden, Netherlands; Sola, I., Department of Molecular and Cell Biology, National Center of Biotechnology (CNB-CSIC), Campus de Cantoblanco, Madrid, Spain; Ziebuhr, J., Institute of Medical Virology, Justus Liebig University Giessen, Giessen, Germany; Coronaviridae Study Group of the International Committee on Taxonomy of Viruses",[No abstract available],,,"Krammer, F., Influenza (2018) Nat. 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Virol., 120, pp. 313-314. , PID: 1958131; (2018) The International Code of Virus Classification and Nomenclature, , https://talk.ictvonline.org/information/w/ictv-information/383/ictv-code; Masters, P.S., The molecular biology of coronaviruses (2006) Adv. Virus Res., 66, pp. 193-292. , COI: 1:CAS:528:DC%2BD1cXhslOhtLw%3D, PID: 16877062; Perlman, S., Netland, J., Coronaviruses post-SARS: update on replication and pathogenesis (2009) Nat. Rev. Microbiol., 7, pp. 439-450. , COI: 1:CAS:528:DC%2BD1MXls1Cmt7k%3D, PID: 19430490; Drosten, C., Identification of a novel coronavirus in patients with severe acute respiratory syndrome (2003) N. Engl. J. Med., 348, pp. 1967-1976. , COI: 1:CAS:528:DC%2BD3sXjslajurw%3D, PID: 12690091; Ksiazek, T.G., A novel coronavirus associated with severe acute respiratory syndrome (2003) N. Engl. J. 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Reorganization of the family Coronaviridae into two families, Coronaviridae (including the current subfamily Coronavirinae and the new subfamily Letovirinae) and the new family Tobaniviridae (accommodating the current subfamily Torovirinae and three other subfamilies), revision of the genus rank structure and introduction of a new subgenus rank. (ICTV; Ziebuhr, J., (2019) Create Ten New Species and a New Genus in the Subfamily Orthocoronavirinae of the Family Coronaviridae and Five New Species and a New Genus in the Subfamily Serpentovirinae of the Family Tobaniviridae, , https://ictv.global/proposal/2019.Nidovirales/, Proposal 2019.021S.Ac.v1, ICTV; de Groot, R.J., (2012) Virus Taxonomy, Ninth Report of the International Committee on Taxonomy of Viruses, pp. 806-828. , King, A. M. Q. et al., Elsevier Academic Press; Lauber, C., Gorbalenya, A.E., Toward genetics-based virus taxonomy: comparative analysis of a genetics-based classification and the taxonomy of picornaviruses (2012) J. 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Virol., 157, pp. 1623-1628. , COI: 1:CAS:528:DC%2BC38XhtFSrt7jO, PID: 22527862; Lu, R., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet, 395, pp. 565-574. , PID: 32007145; Zhou, P., Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin (2020) Nature, , https://doi.org/10.1038/s41586-020-2012-7; Zhu, N., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N. Engl. J. Med., 382, pp. 727-733. , COI: 1:CAS:528:DC%2BB3cXjslGmsrc%3D, PID: 31978945; de Groot, R.J., Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group (2013) J. Virol., 87, pp. 7790-7792. , PID: 23678167, COI: 1:CAS:528:DC%2BC3sXhtFWjt77L; Gorbalenya, A.E., Snijder, E.J., Spaan, W.J., Severe acute respiratory syndrome coronavirus phylogeny: toward consensus (2004) J. 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Virol., 7, pp. 381-388. , COI: 1:CAS:528:DyaK2sXisVeitbs%3D; Luk, H.K.H., Li, X., Fung, J., Lau, S.K.P., Woo, P.C.Y., Molecular epidemiology, evolution and phylogeny of SARS coronavirus (2019) Infect. Genet. Evol., 71, pp. 21-30. , COI: 1:CAS:528:DC%2BC1MXltVChsrY%3D, PID: 30844511; Tao, Y., Surveillance of bat coronaviruses in Kenya identifies relatives of human coronaviruses NL63 and 229E and their recombination history (2017) J. Virol., 91, pp. e01953-e1916. , COI: 1:CAS:528:DC%2BC2sXpvVOnsLg%3D, PID: 28077633; Tao, Y., Tong, S.X., Complete genome sequence of a severe acute respiratory syndrome-related coronavirus from Kenyan bats (2019) Microbiol. Resour. Ann., 8, pp. e00548-e519; Hu, B., Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus (2017) PLoS Pathog., 13. , PID: 29190287, COI: 1:CAS:528:DC%2BC1cXht1OltrjO; Holmes, E.C., Rambaut, A., Viral evolution and the emergence of SARS coronavirus (2004) Philos. T. R. Soc. B, 359, pp. 1059-1065. , COI: 1:CAS:528:DC%2BD2cXnt1ensL0%3D; Hon, C.C., Evidence of the recombinant origin of a bat severe acute respiratory syndrome (SARS)-like coronavirus and its implications on the direct ancestor of SARS coronavirus (2008) J. Virol., 82, pp. 1819-1826. , COI: 1:CAS:528:DC%2BD1cXhvFart7c%3D, PID: 18057240","Gorbalenya, A.E.; Department of Biomedical Data Sciences, Leiden University Medical CenterNetherlands",,Nature Research,20585276,,,32123347,English,Nat. Microbiol.,Article,Article in Press,Open Access,Scopus,2-s2.0-85081266636,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Yang W., Cao Q., Qin L., Wang X., Cheng Z., Pan A., Dai J., Sun Q., Zhao F., Qu J., Yan F.",35800227800;57215590759;57196120190;57215594465;57215573490;57215587830;57215578524;26428426900;57215577035;7201535093;55668864500;,"Clinical characteristics and imaging manifestations of the 2019 novel coronavirus disease (COVID-19):A multi-center study in Wenzhou city, Zhejiang, China",2020,Journal of Infection,80,4,,388,393,,,10.1016/j.jinf.2020.02.016,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081256500&doi=10.1016%2fj.jinf.2020.02.016&partnerID=40&md5=dd846f096f30db03cf6edf694feb6573,"Department of Radiology, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, No.197 Ruijin Er Road, Shanghai, 200025, China; Department of Radiology, Ruian People's Hospital, Ruian, Zhejiang province 325200, China; Department of Radiology, Yueqing People's Hospital, Yueqing, Zhejiang province 325600, China; Department of Infectious Diseases, Wenzhou Central Hospital, Wenzhou, Zhejiang province 325000, China; Department of Infectious Diseases, Ruian People's Hospital, Ruian, Zhejiang province 325200, China; Department of Respiratory and Critical Care Medicine, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, No.197 Ruijin Er Road, Shanghai, 200025, China","Yang, W., Department of Radiology, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, No.197 Ruijin Er Road, Shanghai, 200025, China; Cao, Q., Department of Radiology, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, No.197 Ruijin Er Road, Shanghai, 200025, China; Qin, L., Department of Radiology, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, No.197 Ruijin Er Road, Shanghai, 200025, China; Wang, X., Department of Radiology, Ruian People's Hospital, Ruian, Zhejiang province 325200, China; Cheng, Z., Department of Radiology, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, No.197 Ruijin Er Road, Shanghai, 200025, China; Pan, A., Department of Radiology, Yueqing People's Hospital, Yueqing, Zhejiang province 325600, China; Dai, J., Department of Infectious Diseases, Wenzhou Central Hospital, Wenzhou, Zhejiang province 325000, China; Sun, Q., Department of Infectious Diseases, Ruian People's Hospital, Ruian, Zhejiang province 325200, China; Zhao, F., Department of Infectious Diseases, Wenzhou Central Hospital, Wenzhou, Zhejiang province 325000, China; Qu, J., Department of Respiratory and Critical Care Medicine, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, No.197 Ruijin Er Road, Shanghai, 200025, China; Yan, F., Department of Radiology, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, No.197 Ruijin Er Road, Shanghai, 200025, China","Background: Little is known about COVID-19 outside Hubei. The aim of this paper was to describe the clinical characteristics and imaging manifestations of hospitalized patients with confirmed COVID-19 infection in Wenzhou, Zhejiang, China. Methods: In this retrospective cohort study, 149 RT-PCR confirmed positive patients were consecutively enrolled from January 17th to February 10th, 2020 in three tertiary hospitals of Wenzhou. Outcomes were followed up until Feb 15th, 2020. Findings: A total of 85 patients had Hubei travel/residence history, while another 49 had contact with people from Hubei and 15 had no traceable exposure history to Hubei. Fever, cough and expectoration were the most common symptoms, 14 patients had decreased oxygen saturation, 33 had leukopenia, 53 had lymphopenia, and 82 had elevated C-reactive protein. On chest computed tomography (CT), lung segments 6 and 10 were mostly involved. A total of 287 segments presented ground glass opacity, 637 presented mixed opacity and 170 presented consolidation. Lesions were more localized in the peripheral lung with a patchy form. No significant difference was found between patients with or without Hubei exposure history. Seventeen patients had normal CT on admission of these, 12 had negative findings even10 days later. Interpretation: Most patients presented with a mild infection in our study. The imaging pattern of multifocal peripheral ground glass or mixed opacity with predominance in the lower lung is highly suspicious of COVID-19 in the first week of disease onset. Nevetheless, some patients can present with a normal chest finding despite testing positive for COVID-19. Funding: We did not receive any fundings. © 2020",COVID-19; CT; Infection; Lung; Outside Hubei,,"Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 [published online ahead of print, 2020 Jan 24] (2020) N Engl J Med; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China [published online ahead of print, 2020 Jan 24] (2020) Lancet, , S0140-6736(20)30183-5; Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia [published online ahead of print, 2020 Jan 29] (2020) N Engl J Med; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. [published online ahead of print, 2020 Jan 29]. Lancet; Chan, J.F., Yuan, S., Kok, K.H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster [published online ahead of print, 2020 Jan 24] (2020) Lancet, , S0140-6736(20)30154-9; Wang, D., Hu, B., Hu, C., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China [published online ahead of print, 2020 Feb 7] (2020) JAMA; http://www.nhc.gov.cn/xcs/yqtb/202002/4a611bc7fa20411f8ba1c8084426c0d4.shtml, National health commission of the People's Republic of China; Chang, D., Lin, M., Wei, L., Epidemiologic and clinical characteristics of novel coronavirus infections involving 13 patients outside Wuhan, China [published online ahead of print, 2020 Feb 7] (2020) JAMA; Wei-jie Guan, Zheng-yi Ni, Yu Hu, et al. 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Statistical inference for coronavirus infected patients in Wuhan. medRxiv2020.02.10.20021774;; Blumberg, S., Lloyd-Smith, J.O., Inference of R(0) and transmission heterogeneity from the size distribution of stuttering chains (2013) PLoS Comput Biol, 9; Song, F., Shi, N., Shan, F., Emerging Coronavirus 2019-nCoV Pneumonia [published online ahead of print, 2020 Feb 6] (2020) Radiology; Chung, M., Bernheim, A., Mei, X., CT imaging features of 2019 novel coronavirus (2019-nCoV) (2020) Radiology, , [published online ahead of print, 2020 Feb 4]; Müller, N.L., Ooi, G.C., Khong, P.L., Nicolaou, S., Severe acute respiratory syndrome: radiographic and CT findings (2003) AJR Am J Roentgenol, 181 (1), pp. 3-8; Müller, N.L., Ooi, G.C., Khong, P.L., Zhou, L.J., Tsang, K.W., Nicolaou, S., High-resolution CT findings of severe acute respiratory syndrome at presentation and after admission (2004) AJR Am J Roentgenol, 182 (1), pp. 39-44; Chan, M.S., Chan, I.Y., Fung, K.H., Poon, E., Yam, L.Y., Lau, K.Y., High-resolution CT findings in patients with severe acute respiratory syndrome: a pattern-based approach (2004) AJR Am J Roentgenol, 182 (1), pp. 49-56; Wong, K.T., Antonio, G.E., Hui, D.S., Thin-section CT of severe acute respiratory syndrome: evaluation of 73 patients exposed to or with the disease (2003) Radiology, 228 (2), pp. 395-400; Ajlan, A.M., Ahyad, R.A., Jamjoom, L.G., Alharthy, A., Madani, T.A., Middle East respiratory syndrome coronavirus (MERS-CoV) infection: chest CT findings (2014) AJR Am J Roentgenol, 203 (4), pp. 782-787; Das, K.M., Lee, E.Y., Langer, R.D., Larsson, S.G., Middle east respiratory syndrome coronavirus: what does a radiologist need to know? (2016) AJR Am J Roentgenol, 206 (6), pp. 1193-1201; Xie, X., Zhong, Z., Zhao, W., Zheng, C., Wang, F., Liu, J., Chest CT for typical 2019-nCoV pneumonia: relationship to negative RT-PCR testing (2020) Radiology","Qu, J.; Department of Respiratory and Critical Care Medicine, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, No.197 Ruijin Er Road, China; email: jmqu0906@163.com",,W.B. Saunders Ltd,1634453,,JINFD,32112884,English,J. Infect.,Article,Final,Open Access,Scopus,2-s2.0-85081256500,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Tahiri Joutei Hassani R., Sandali O.",36627679400;57215580214;,The novel coronavirus Covid-19: What are the ophthalmic risks? [Le nouveau Coronavirus Covid-19: quels risques ophtalmiques ?],2020,Journal Francais d'Ophtalmologie,43,4,,291,293,,,10.1016/j.jfo.2020.02.001,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081226320&doi=10.1016%2fj.jfo.2020.02.001&partnerID=40&md5=70507a52b3fe4dd88aecc31dee9fcf63,"Service de chirurgie ambulatoire, centre hospitalier d'Avranches Granville, 849, rue des Menneries, Granville, 50400, France; Service de chirurgie ambulatoire, clinique Guillaume-de-Varye, Bourges, France","Tahiri Joutei Hassani, R., Service de chirurgie ambulatoire, centre hospitalier d'Avranches Granville, 849, rue des Menneries, Granville, 50400, France; Sandali, O., Service de chirurgie ambulatoire, clinique Guillaume-de-Varye, Bourges, France",[No abstract available],,China; Coronavirinae; coronavirus disease 2019; Coronavirus infection; coughing; dyspnea; Editorial; eye examination; fever; human; incubation time; mortality rate; nonhuman; ophthalmology; quarantine; severe acute respiratory syndrome coronavirus 2; slit lamp microscopy; viral conjunctivitis; virus load; virus transmission,"Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506; https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200225-sitrep-36-covid-19.pdf, World Health Organization (WHO). Coronavirus disease 2019 (COVID-19) Situation Report–36: (accessed 25 Feb 2020); (2005), https://www.who.int/news-room/detail/30-01-2020-statement-on-the-second-meeting-of-the-international-health-regulations–emergency-committee-regarding-the-outbreak-of-novel-coronavirus-(2019-ncov, World Health Organization (WHO). Statement on the second meeting of the International Health Regulations Emergency Committee regarding the outbreak of novel coronavirus (2019-nCoV).) (accessed 22 Feb 2020); Chen, J., Pathogenicity and transmissibility of 2019-nCoV – A quick overview and comparison with other emerging viruses (2020) Microbes Infect., , pii: S1286-4579(20)30026-5. [Epub ahead of print]; Lu, C.W., Liu, X.F., Jia, Z.F., 2019-nCoV transmission through the ocular surface must not be ignored (2020) Lancet, , Feb 6. pii: S0140-6736(20)30313-5; https://www.sfo-online.fr/actualites/informations-concernant-linfection-au-coronavirus, Société Française d'Ophtalmologie Online. Informations concernant l'infection au coronavirus. (accessed 22 Feb 2020); https://www.aao.org/headline/alert-important-coronavirus-context, American Academy of Ophthalmology. Alert: important coronavirus context for ophthalmologists. (accessed 22 Feb 2020); Rothe, C., Schunk, M., Sothmann, P., Bretzel, G., Froeschl, G., Wallrauch, C., Transmission of 2019-nCoV infection from an asymptomatic contact in Germany (2020) N Engl J Med; Dai, X., http://www.bjnews.com.cn/news/2020/01/23/678189.html, Peking University Hospital Wang Guangfa disclosed treatment status on Weibo and suspected infection without wearing goggles. (accessed 24 Jan 2020); https://www.doctissimo.fr/sante/news/deces-li-wenliang-lanceur-alerte-coronavirus, Doctissimo. Li Wenliang, le médecin lanceur d'alerte sur le coronavirus, est décédé. (accessed 22 Feb 2020)","Tahiri Joutei Hassani, R.; Service de chirurgie ambulatoire, centre hospitalier d'Avranches Granville, 849, rue des Menneries, France; email: tjhr78@hotmail.com",,Elsevier Masson SAS,1815512,,JFOPD,,English; French,J. Fr. Ophtalmol.,Editorial,Final,Open Access,Scopus,2-s2.0-85081226320,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Gao Q.Y., Chen Y.X., Fang J.Y.",53263723200;57215581339;55537217000;,2019 Novel coronavirus infection and gastrointestinal tract,2020,Journal of Digestive Diseases,,,,,,,1,10.1111/1751-2980.12851,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081205867&doi=10.1111%2f1751-2980.12851&partnerID=40&md5=0d3c870f312c63bef42f5bb60da8d7c0,"Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology & Hepatology, Ministry of Health, State Key Laboratory of Oncogene and Related Genes, Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China","Gao, Q.Y., Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology & Hepatology, Ministry of Health, State Key Laboratory of Oncogene and Related Genes, Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Chen, Y.X., Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology & Hepatology, Ministry of Health, State Key Laboratory of Oncogene and Related Genes, Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Fang, J.Y., Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology & Hepatology, Ministry of Health, State Key Laboratory of Oncogene and Related Genes, Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China",[No abstract available],,,"Wu, F., Zhao, S., Yu, B., A new coronavirus associated with human respiratory disease in China [published online ahead of print February 3, 2020] Nature, , https://doi.org/10.1038/s41586-020-2008-3; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet., 395 (10223), pp. 507-513; Wang, D., Hu, B., Hu, C., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China [published online ahead of print February 7, 2020] JAMA, , https://doi.org/10.1001/jama.2020.1585; Zhang, W., Du, R.H., Li, B., Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes (2020) Emerg Microbes Infect., 9 (1), pp. 386-389; Lu, R., Zhao, X., Li, J., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet., 395 (10224), pp. 565-574; Chai, Z., Hu, L., Zhang, Y., www.biorxiv.org, Specific ACE2 expression in cholangiocytes may cause liver damage after 2019-nCoV infection [Epub on, February 04, 2020]. Available from, https://www.biorxiv.org/content/10.1101/2020.02.03.931766v1; Hashimoto, T., Perlot, T., Rehman, A., ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation (2012) Nature., 487 (7408), pp. 477-481; Bradley, K.C., Finsterbusch, K., Schnepf, D., Microbiota-driven tonic interferon signals in lung stromal cells protect from influenza virus infection (2019) Cell Rep, 28 (1), pp. 245-256.e4; http://www.nhc.gov.cn/yzygj/s7653p/202002/d4b895337e19445f8d728fcaf1e3e13a/files/ab6bec7f93e64e7f998d802991203cd6.pdf, National Administration of Traditional Chinese Medicine. Diagnostic and therapeutic guidance for 2019 novel coronavirus disease (version 5). Available from","Fang, J.Y.; Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology & Hepatology, Ministry of Health, State Key Laboratory of Oncogene and Related Genes, Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityChina; email: jingyuanfang@sjtu.edu.cn",,Blackwell Publishing,17512972,,,32096611,English,J. Dig. Dis.,Editorial,Article in Press,Open Access,Scopus,2-s2.0-85081205867,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Jiang S.,57215544230;,"Correction to: An emerging coronavirus causing pneumonia outbreak in Wuhan, China: calling for developing therapeutic and prophylactic strategies (Emerging Microbes & Infections, (2020), 9, 1, (275-277), 10.1080/22221751.2020.1723441)",2020,Emerging Microbes and Infections,9,1,,539,,,,10.1080/22221751.2020.1737363,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081135591&doi=10.1080%2f22221751.2020.1737363&partnerID=40&md5=f2e2d28d72d46c4a0fe0a42e4831c895,,"Jiang, S.","When the article was first published online, there were few corrections in Figure 1. This has now been corrected in online. © 2020, © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd.",,erratum,,"Jiang, S.",,Taylor and Francis Ltd.,22221751,,,32134367,English,Emerg. Microbes Infect.,Erratum,Final,Open Access,Scopus,2-s2.0-85081135591,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Ponce-de-León A., Galindo-Fraga A., Ruiz-Palacios G.M., Sifuentes-Osornio J.",57197249048;6508359924;7006106839;7003764364;,WUHAN: BACK TO THE FUTURE AND THE RETURN OF CORONAVIRUSES,2020,Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion,72,1,,5,7,,,10.24875/RIC.20000023,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081042707&doi=10.24875%2fRIC.20000023&partnerID=40&md5=84a174c5b2c100d585023a168eefa8a1,"Departament of Infectology, Hospital Epidemiology and Quality Control of Medical Atentionand Mexico City, Mexico; Subdirectorate of Hospital Epidemiology and Quality Control of Medical Atentionand Mexico City, Mexico; Directorate of Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico City, Mexico","Ponce-de-León, A., Departament of Infectology, Hospital Epidemiology and Quality Control of Medical Atentionand Mexico City, Mexico; Galindo-Fraga, A., Subdirectorate of Hospital Epidemiology and Quality Control of Medical Atentionand Mexico City, Mexico; Ruiz-Palacios, G.M., Departament of Infectology, Hospital Epidemiology and Quality Control of Medical Atentionand Mexico City, Mexico; Sifuentes-Osornio, J., Directorate of Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico City, Mexico",[No abstract available],,,,,,NLM (Medline),348376,,,32132737,English,Rev. Invest. Clin.,Article,Final,Open Access,Scopus,2-s2.0-85081042707,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhan S., Yang Y.Y., Fu C.",57215426301;57215414814;23018368200;,Public’s early response to the novel coronavirus–infected pneumonia,2020,Emerging Microbes and Infections,9,1,,534,,,,10.1080/22221751.2020.1732232,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080941921&doi=10.1080%2f22221751.2020.1732232&partnerID=40&md5=8959e1da18a06fe1ec2a8f29909e0ac6,"From the School of Public Health, Zhejiang Chinese Medical University, Hangzhou, China","Zhan, S., From the School of Public Health, Zhejiang Chinese Medical University, Hangzhou, China; Yang, Y.Y., From the School of Public Health, Zhejiang Chinese Medical University, Hangzhou, China; Fu, C., From the School of Public Health, Zhejiang Chinese Medical University, Hangzhou, China",[No abstract available],,"antivirus agent; virus vaccine; COVID-19; adult; antiviral therapy; attitude to health; attitude to illness; China; Coronavirus infection; female; hand washing; health education; human; infection prevention; Letter; male; middle aged; normal human; novel coronavirus infected pneumonia; priority journal; quarantine; virus pneumonia; young adult; anxiety; Coronavirus infection; epidemic; health behavior; public health; virus pneumonia; Anxiety; China; Coronavirus Infections; Disease Outbreaks; Health Behavior; Humans; Pneumonia, Viral; Public Health","Update on Pneumonia of 2019-Ncov Infections as of 24:00 on Feb 2, , http://www.nhc.gov.cn/xcs/yqtb/202002/24a796819bf747bd8b945384517e9a51.shtml, [cited 2020 Feb 3]. Available from; Li, Q., Guan, X., Wang, X., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med, , https://doi.org/10.1056/NEJMoa2001316, Jan 29; https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200203-sitrep-14-ncov.pdf?sfvrsn=f7347413_2, [cited 2020 Feb 4], Available from; Wong, T.-W., Tam, W.W.-S., Handwashing practice and the use of personal protective equipment among medical students after the SARS epidemic in Hong Kong (2005) Am J Infect Control, 33 (10), pp. 580-586; MacIntyre, C.R., Chughtai, A.A., Rahman, B., The efficacy of medical masks and respirators against respiratory infection in healthcare workers (2017) Influenza Other Respir Viruses, 11 (6), pp. 511-517","Fu, C.; From the School of Public Health, Zhejiang Chinese Medical University, No 548, Binwen Rd, China; email: fuchuanxi@gmail.com",,Taylor and Francis Ltd.,22221751,,,32122250,English,Emerg. Microbes Infect.,Letter,Final,Open Access,Scopus,2-s2.0-85080941921,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Kramer A.,57207908385;,What protects? Fear of coronavirus infections moves hygienic measures to the fore [Was schützt? Angst vor Coronavirus-Infektionen rückt Hygienemaßnahmen in den Fokus],2020,Deutsche Apotheker Zeitung,,7, A77,,,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080930991&partnerID=40&md5=f4880c76a7c32f763c6b9676b1b1ae27,"Institut für Hygiene und Umweltmedizin, Universitätsmedizin Greifswald, Ferdinand-Sauerbruch-Str. 4, Greifswald, 17475, Germany","Kramer, A., Institut für Hygiene und Umweltmedizin, Universitätsmedizin Greifswald, Ferdinand-Sauerbruch-Str. 4, Greifswald, 17475, Germany",[No abstract available],,Article; Coronavirus infection; fear; hygiene; infection prevention,,"Kramer, A.; Institut für Hygiene und Umweltmedizin, Universitätsmedizin Greifswald, Ferdinand-Sauerbruch-Str. 4, Germany",,Deutscher Apotheker Verlag,119857,,DAZEA,,German,Dtsch. Apoth. Ztg.,Article,Final,,Scopus,2-s2.0-85080930991,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Liang W., Feng Z., Rao S., Xiao C., Xue X., Lin Z., Zhang Q., Qi W.",57215417925;24173124800;56707931700;57215412523;57215434559;54788082800;57215422173;57207013275;,Diarrhoea may be underestimated: A missing link in 2019 novel coronavirus,2020,Gut,,,,,,,2,10.1136/gutjnl-2020-320832,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080919920&doi=10.1136%2fgutjnl-2020-320832&partnerID=40&md5=cfb8eb2025773a0681be8cc90bb27512,"Cell-gene Therapy Translational Medicine Research Center, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Liver Disease Research, Guangzhou, China; Department of Gastroenterology, Second Hospital of Hebei Medical University, Hebei Key Laboratory of Gastroenterology, Hebei Institute of Gastroenterology, Shijiazhuang, China; School of Biomedical Sciences, Chinese University of Hong Kong, Shatin, Hong Kong; Department of Thoracic Surgery, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, China; Department of Medical Oncology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China","Liang, W., Cell-gene Therapy Translational Medicine Research Center, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, Guangdong Provincial Key Laboratory of Liver Disease Research, Guangzhou, China; Feng, Z., Department of Gastroenterology, Second Hospital of Hebei Medical University, Hebei Key Laboratory of Gastroenterology, Hebei Institute of Gastroenterology, Shijiazhuang, China; Rao, S., School of Biomedical Sciences, Chinese University of Hong Kong, Shatin, Hong Kong; Xiao, C., Cell-gene Therapy Translational Medicine Research Center, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, Guangdong Provincial Key Laboratory of Liver Disease Research, Guangzhou, China; Xue, X., Department of Thoracic Surgery, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, China; Lin, Z., Guangdong Provincial Key Laboratory of Liver Disease Research, Guangzhou, China, Department of Medical Oncology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Zhang, Q., Cell-gene Therapy Translational Medicine Research Center, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, Guangdong Provincial Key Laboratory of Liver Disease Research, Guangzhou, China; Qi, W., Department of Gastroenterology, Second Hospital of Hebei Medical University, Hebei Key Laboratory of Gastroenterology, Hebei Institute of Gastroenterology, Shijiazhuang, China",[No abstract available],diarrhoea; intestinal epithelium; intestinal gene regulation,,"Chan, J.-W., Yuan, S., Kok, K.-H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: A study of a family cluster (2020) Lancet, 395, pp. 514-523. , http://dx.doi.org/10.1016/S0140-6736(20)30154-9; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study (2020) Lancet, 395, pp. 507-513. , http://dx.doi.org/10.1016/S0140-6736(20)30211-7; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506. , http://dx.doi.org/10.1016/S0140-6736(20)30183-5; Zhou, P.Y.X., Wang, X., Hu, B., Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin (2020) BioRxiv; Letko, M.M.V., Functional assessment of cell entry and receptor usage for lineage B β-coronaviruses, including 2019-nCoV (2020) BioRxiv; Hashimoto, T., Perlot, T., Rehman, A., ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation (2012) Nature, 487, pp. 477-481. , http://dx.doi.org/10.1038/nature11228; Haber, A.L., Biton, M., Rogel, N., A single-cell survey of the small intestinal epithelium (2017) Nature, 551, pp. 333-339. , http://dx.doi.org/10.1038/nature24489; Zhang, H.K.Z., Gong, H., Xu, D., The digestive system is a potential route of 2019-nCov infection: A bioinformatics analysis based on single-cell transcriptomes (2020) BioRxiv; Zhou, J., Li, C., Zhao, G., Human intestinal tract serves as an alternative infection route for middle East respiratory syndrome coronavirus (2017) Sci Adv, 3. , http://dx.doi.org/10.1126/sciadv.aao4966, eaao4966; Wang, C., Horby, P.W., Hayden, F.G., A novel coronavirus outbreak of global health concern (2020) Lancet, 395, pp. 470-473. , http://dx.doi.org/10.1016/S0140-6736(20)30185-9","Qi, W.; Department of Gastroenterology, Hebei Institute of Gastroenterology, Second Hospital of Hebei Medical UniversityChina; email: chinaqiwei@yahoo.com",,BMJ Publishing Group,175749,,GUTTA,32102928,English,Gut,Letter,Article in Press,Open Access,Scopus,2-s2.0-85080919920,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Han Q., Lin Q., Ni Z., You L.",57204127908;57212513379;57215427498;54951206100;,Uncertainties about the transmission routes of 2019 novel coronavirus,2020,Influenza and other Respiratory Viruses,,,,,,,1,10.1111/irv.12735,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080899340&doi=10.1111%2firv.12735&partnerID=40&md5=6d21648e9f0c871b188081b6674dc7f1,"The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China; Department of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China; Malignant Lymphoma Diagnosis and Therapy Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China","Han, Q., The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China, Department of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China, Malignant Lymphoma Diagnosis and Therapy Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China; Lin, Q., The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China, Department of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China, Malignant Lymphoma Diagnosis and Therapy Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China; Ni, Z., The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China; You, L., The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China, Department of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China, Malignant Lymphoma Diagnosis and Therapy Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China",[No abstract available],,,"Mahase, E., China coronavirus: mild but infectious cases may make it hard to control outbreak, report warns (2020) BMJ, 368, p. m325; Wang, F.S., Zhang, C., What to do next to control the 2019-ncovepidemic? (2020) Lancet, 395 (10222), pp. 391-393; Question and answer on coronaviruses, , https://www.who.int/news-room/g-a-detail/q-a-coronaviruses.pdf, Accessed February 11, 2020; Kampf, G., Todt, D., Pfaender, S., Steinmann, E., Persistence of coronaviruses on inanimate surfaces and its inactivation with biocidal agents (2020) J Hosp Infect, , http://doi.org/10.1016/j.jhin.2020.01.022, [Epub ahead of print]; The SRAS-COV-2 nucleic acid detected for the first time on the surface of door handle in Guangzhou and cleaning taken attention, , http://www.chinanews.com/sh/2020/02-03/9076856.shtml.pdf, Accessed February 3, 2020; The SRAS-COV-2 isolated from the stool specimens of patients with novel coronavirus-infected pneumonia by teams of Nanshan Zhong Professor and Lanjuan Li Professor, , http://www.chinanews.com/gn/2020/02-13/9090170.shtml.pdf, Accessed February 13, 2020; Hamming, I., Timens, W., Bulthuis, M.L., Lely, A.T., Navis, G., van Goor, H., Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis (2004) J Pathol, 203 (2), pp. 631-637; Christian, M.D., Poutanen, S.M., Loutfy, M.R., Muller, M.P., Low, D.E., Severe acute respiratory syndrome (2004) Clin Infect Dis, 38, pp. 1420-1427; Peiris, J.S., Chu, C.M., Cheng, V.C., Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study (2003) Lancet, 361 (9371), pp. 1767-1772; Chen, H.J., Guo, J.J., Wang, C., Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records (2020) Lancet; A 30-hour old newborn in Wuhan confirmed as patient with novel coronavirus-infected pneumonia and vertical transmission suspected, , http://www.chinanews.com/sh/2020/02-05/9080056.shtml.pdf, Accessed February 5, 2020; Lu, C.W., Liu, X.F., Jia, Z.F., 2019-nCoV transmission through the ocular surface must not be ignored (2020) Lancet, 395 (10224); Zhou, Y.Y., Zeng, Y.Y., Tong, Y.Q., Chen, C.Z., Ophthalmologic evidence against the interpersonal transmission of 2019 novel coronavirus through conjunctiva (2020) MedRxiv","You, L.; The First Affiliated Hospital, College of Medicine, Zhejiang UniversityChina; email: youliangshun@zju.edu.cn",,Blackwell Publishing Ltd,17502640,,,,English,Influ. Other Respir. Viruses,Letter,Article in Press,Open Access,Scopus,2-s2.0-85080899340,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Khan S., Siddique R., Ali A., Xue M., Nabi G.",57192387486;57192396029;57213370320;57215214498;57189842203;,"Novel coronavirus, poor quarantine, and the risk of pandemic",2020,Journal of Hospital Infection,,,,,,,1,10.1016/j.jhin.2020.02.002,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080124088&doi=10.1016%2fj.jhin.2020.02.002&partnerID=40&md5=d4883df16330c04583b7751cb270f5d9,"Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Henan Medical Key Laboratory of Translational Cerebrovascular Diseases, Zhengzhou, China; Wuhan Institute of Virology, Chinese Academy of Sciences, Xiao Hong Shan No. 44, Wuhan, China; University of Chinese Academy of Sciences, Beijing, China; Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei Province, College of Life Sciences, Hebei Normal University, Shijiazhuang, China","Khan, S., Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China, Henan Medical Key Laboratory of Translational Cerebrovascular Diseases, Zhengzhou, China; Siddique, R., Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China, Henan Medical Key Laboratory of Translational Cerebrovascular Diseases, Zhengzhou, China; Ali, A., Wuhan Institute of Virology, Chinese Academy of Sciences, Xiao Hong Shan No. 44, Wuhan, China, University of Chinese Academy of Sciences, Beijing, China; Xue, M., Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China, Henan Medical Key Laboratory of Translational Cerebrovascular Diseases, Zhengzhou, China; Nabi, G., Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei Province, College of Life Sciences, Hebei Normal University, Shijiazhuang, China",[No abstract available],,,"Hui, D.S., Azhar, I.E., Madani, T.A., Ntoumi, F., Kock, R., Dar, O., The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health – the latest 2019 novel coronavirus outbreak in Wuhan, China (2020) Int J Infect Dis, 91, pp. 264-266; Construction of Wuhan prefab hospitals close to completion https://news.cgtn.com/news/2020-02-01/Live-Construction-of-Wuhan-prefab-hospitals-close-to-completion-NIXXlAH6yA/index.html, February 2nd, 2020 Available at: [last accessed February 2020]; Kato, F., Tainaka, K.I., Sone, S., Morita, S., Iida, H., Yoshimura, J., Combined effects of prevention and quarantine on a breakout in SIR model (2011) Sci Rep, 1, pp. 1-5; Chen, Y., Liu, Q., Guo, D., Emerging coronaviruses genome structure, replication, and pathogenesis (2020) J Med Virol, 92, pp. 418-423; Nature news, Coronavirus latest: WHO declares global emergency Nature, , https://www.nature.com/articles/d41586-020-00154-w, Jan 30th, 2020 Available at: [last accessed February 2020]; Mandavilli, A., SARS epidemic unmasks age-old quarantine conundrum (2003) Nat Med, 9, p. 487","Khan, S.; Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou UniversityChina; email: Suliman.khan18@mails.ucas.ac.cn",,W.B. Saunders Ltd,1956701,,JHIND,32057788,English,J. Hosp. Infect.,Note,Article in Press,Open Access,Scopus,2-s2.0-85080124088,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Peng P.W.H., Ho P.-L., Hota S.S.",14123631500;7402211363;6603333520;,Outbreak of a new coronavirus: what anaesthetists should know,2020,British Journal of Anaesthesia,,,,,,,5,10.1016/j.bja.2020.02.008,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080094632&doi=10.1016%2fj.bja.2020.02.008&partnerID=40&md5=ea1163cb8ecd6ee0d1d70bc4514c23fd,"Department of Anesthesiology and Pain Medicine, University Health Network, University of Toronto, Toronto, ON, Canada; Department of Microbiology and Carol Yu Centre for Infection, University of Hong Kong, Hong Kong; Infection Prevention and Control Department, University Health Network, Toronto, ON, Canada; Department of Medicine, University of Toronto, Toronto, ON, Canada","Peng, P.W.H., Department of Anesthesiology and Pain Medicine, University Health Network, University of Toronto, Toronto, ON, Canada; Ho, P.-L., Department of Microbiology and Carol Yu Centre for Infection, University of Hong Kong, Hong Kong; Hota, S.S., Infection Prevention and Control Department, University Health Network, Toronto, ON, Canada, Department of Medicine, University of Toronto, Toronto, ON, Canada",[No abstract available],2019-nCoV; airway management; coronavirus; COVID-19; infection prevention and control; MERS; SARS,,"Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506; Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med Adv, 24. , Acccess Published January; Novel coronavirus (2019-nCoV) situation report (2020), https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports, Available from: (Accessed 9 February 2020); Parry, J., China coronavirus: cases surge as official admits human to human transmission (2020) BMJ, 368, p. m236; Cheng, V.C.C., Wong, S.C., To, K.K.W., Ho, P.L., Yuen, K.Y., Preparedness and proactive infection control measures against the emerging Wuhan coronavirus pneumonia in China (2020) J Hosp Infect 2020 Adv, 18. , Acccess Published January; Holshue, M.L., DeBolt, C., Lindquist, S., First case of 2019 novel coronavirus in the United States (2020) N Engl J Med Adv, 31. , Acccess Published January; Lu, R.J., Zhao, X., Li, J., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet Adv, 29. , Acccess Published January; Chan, J.F., Kok, K.H., Zhu, Z., Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan (2020) Emerg Microbe. Infect, 9, pp. 221-236; Zhang, L.S., Shen, F.M., Chen, F., Lin, Z.G., Origin and evolution of the 2019 novel coronavirus (2020) Clin Infect Dis Adv, 3. , Access Published February; 2019 Novel coronavirus https://www.cdc.gov/coronavirus/2019-ncov/faq.html, Available from: (Accessed 8 February 2020); Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med Adv, 29. , Acccess Published January; Wu, J.T., Leung, K., Leung, G.M., Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study (2020) Lancet Adv, 31. , Acccess Published January; Chen, N., Zhou, M., Dong, X., Novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet Adv, 29. , 2019 Acccess Published January; Ghani, A.C., Donnelly, C.A., Cox, D.R., Methods for estimating the case fatality ratio for a novel, emerging infectious disease (2005) Am J Epidemiol, 162, pp. 479-486; World Health Organization, Summary of probable SARS cases with onset of illness from 1 November 2002 to 31 July 2003 (2004), https://www.who.int/csr/sars/country/table2004_04_21/en, Available from: (Accessed 7 February 2020); World Health Organization, Middle East respiratory syndrome coronavirus (MERS-CoV) (2020), http://www.who.int/emergencies/mers-cov/en/, Available from: (Accessed 9 February 2020); World Health Organization, International health regulations (2005), https://apps.who.int/iris/bitstream/handle/10665/246107/9789241580496-eng.pdf;jsessionid=CEB2B12AFC7EB3DE9E2993B7CFA6E5AB?sequence=1, Available from: (Accessed 9 February 2020); World Health Organization, Novel coronavirus (2019-nCoV) technical guidance: laboratory testing for 2019-nCoV in humans (2020), https://www.who.int/emergencies/diseases/novel-coronavirus-2019/technical-guidance/laboratory-guidance, Available from: (Accessed 9 February 2020); Hung, C.T., Ho, P.L., High-risk procedures: how to play it safe (2006) Challenges of severe acute respiratory syndrome, pp. 205-224. , J.C.K. Chan V.C.W. Taam Wong Saunders Elsevier Hong Kong; World Health Organization, Novel coronavirus (2019-nCoV) technical guidance: infection prevention and control (2020), https://www.who.int/emergencies/diseases/novel-coronavirus-2019/technical-guidance/infection-prevention-and-control, Available from: (Accessed 9 February 2020); Nicolle, L., SARS safety and science (2003) Can J Anesth, 50, pp. 983-988; Loeb, M., McGeer, A., Henry, B., SARS among critical care nurses, Toronto (2004) Emerg Infect Dis, 10, pp. 251-255; Caputo, K.M., Byrick, R., Chapman, M.G., Orser, B.A., Intubation of SARS patients: infection and perspectives of healthcare workers (2006) Can J Anaesth, 53, pp. 122-129; Interim infection prevention and control recommendations for patients with confirmed 2019 novel coronavirus (2019-nCoV) or persons under investigation for 2019-nCoV in healthcare settings (2020), https://www.cdc.gov/coronavirus/2019-nCoV/hcp/infection-control.html, Available from: (Accessed 9 February 2020); Coronavirus and safety precaution (2020), https://www.anesthesia.utoronto.ca/news/coronavirus-and-safety-precautions, Available from: (Accessed 9 February 2020)","Peng, P.W.H.; Department of Anesthesiology and Pain Medicine, University Health Network, University of TorontoCanada; email: Philip.peng@uhn.ca",,Elsevier Ltd,70912,,BJANA,,English,Br. J. Anaesth.,Editorial,Article in Press,Open Access,Scopus,2-s2.0-85080094632,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Al-Tawfiq J.A.,9436438200;,Asymptomatic coronavirus infection: MERS-CoV and SARS-CoV-2 (COVID-19),2020,Travel Medicine and Infectious Disease,,,101608,,,,4,10.1016/j.tmaid.2020.101608,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080072706&doi=10.1016%2fj.tmaid.2020.101608&partnerID=40&md5=da6a3e69956b6efa994e1f1b64cc6711,"Specialty Internal Medicine and Quality Department, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia; Indiana University School of MedicineIN, United States; Johns Hopkins University School of Medicine, Baltimore, MD, United States","Al-Tawfiq, J.A., Specialty Internal Medicine and Quality Department, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia, Indiana University School of MedicineIN, United States, Johns Hopkins University School of Medicine, Baltimore, MD, United States",[No abstract available],,,"Al-Tawfiq, J.A., Gautret, P., Asymptomatic Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection: extent and implications for infection control: a systematic review (2019) Trav Med Infect Dis, 27, pp. 27-32; Granados, A., Goodall, E.C., Luinstra, K., Smieja, M., Mahony, J., Comparison of asymptomatic and symptomatic rhinovirus infections in university students: incidence, species diversity, and viral load (2015) Diagn Microbiol Infect Dis, 82, pp. 292-296; Camargo, C.N., Carraro, E., Granato, C.F., Bellei, N., Human rhinovirus infections in symptomatic and asymptomatic subjects (2012) Braz J Microbiol, 43, p. 1641; Furuya-Kanamori, L., Cox, M., Milinovich, G.J., Magalhaes, R.J.S., Mackay, I.M., Yakob, L., Heterogeneous and dynamic prevalence of asymptomatic influenza virus infections (2016) Emerg Infect Dis, 22, pp. 1052-1056; Wilder-Smith, A., Teleman, M.D., Heng, B.H., Earnest, A., Ling, A.E., Leo, Y.S., Asymptomatic SARS coronavirus infection among healthcare workers, Singapore (2005) Emerg Infect Dis, 11, pp. 1142-1145; Rothe, C., Schunk, M., Sothmann, P., Bretzel, G., Froeschl, G., Wallrauch, C., Transmission of 2019-nCoV infection from an asymptomatic contact in Germany (2020) N Engl J Med; Chan, J.F.-W., Yuan, S., Kok, K.-H., To, K.K.-W., Chu, H., Yang, J., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet","Al-Tawfiq, J.A.; Specialty Internal Medicine and Quality Department, Johns Hopkins Aramco HealthcareSaudi Arabia; email: jaffar.tawfiq@jhah.com",,Elsevier USA,14778939,,TMIDA,,English,Travel Med. Infect. Dis.,Article,Article in Press,Open Access,Scopus,2-s2.0-85080072706,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Shi H., Han X., Zheng C.",12789169600;57208739929;57215864065;,"Evolution of CT manifestations in a patient recovered from 2019 novel coronavirus (2019-NCoV) pneumonia in Wuhan, China",2020,Radiology,295,1,,20,,,4,10.1148/radiol.2020200269,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080047795&doi=10.1148%2fradiol.2020200269&partnerID=40&md5=2bb0508d35e1d4159e2504a2b9a372b2,"Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Rd, Wuhan, Hubei Province 430022, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China","Shi, H., Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Rd, Wuhan, Hubei Province 430022, China, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China; Han, X., Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Rd, Wuhan, Hubei Province 430022, China, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China; Zheng, C., Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Rd, Wuhan, Hubei Province 430022, China, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, China",[No abstract available],,"ganciclovir; linezolid; meropenem; oseltamivir; antiinflammatory agent; antivirus agent; COVID-19; severe acute respiratory syndrome coronavirus 2; 2019 novel coronavirus; abnormal respiratory sound; adult; case report; China; clinical article; computer assisted tomography; Coronaviridae; Coronavirus infection; coughing; emergency ward; fatigue; fever; hospital admission; hospital discharge; human; human cell; laboratory test; leukopenia; lung auscultation; male; Note; priority journal; real time polymerase chain reaction; sputum examination; virus pneumonia; Betacoronavirus; complication; Coronavirus infection; coughing; diagnostic imaging; fatigue; fever; isolation and purification; lung; middle aged; pathology; thorax radiography; virus pneumonia; x-ray computed tomography; Anti-Inflammatory Agents; Antiviral Agents; Betacoronavirus; Coronavirus Infections; Cough; Fatigue; Fever; Humans; Lung; Male; Middle Aged; Patient Discharge; Pneumonia, Viral; Radiography, Thoracic; Real-Time Polymerase Chain Reaction; Tomography, X-Ray Computed","Novel Coronavirus–China, , http://www.who.int/csr/don/12-january-2020-novel-coronavirus-china/en, PublishedJanuary 12, 2020; (2020) WHO/Novel Coronavirus–China, , World Health Organization. Geneva, Switzerland: World Health Organization","Shi, H.; Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Rd, China; email: hqzcsxh@sina.com",,Radiological Society of North America Inc.,338419,,RADLA,32032497,English,Radiology,Note,Final,Open Access,Scopus,2-s2.0-85080047795,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Fang Y., Zhang H., Xu Y., Xie J., Pang P., Ji W.",57215864155;57215863571;57215864099;57215863820;57215863623;57216090553;,CT manifestations of two cases of 2019 novel coronavirus (2019-NCoV) pneumonia,2020,Radiology,295,1,,208,209,,3,10.1148/radiol.2020200280,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080030605&doi=10.1148%2fradiol.2020200280&partnerID=40&md5=dd101d29641b180f3ed3351620a1e8a4,"2019-nCoV Investigating and Research Team, Department of Radiology, Affiliated Taizhou Hospital of Wenzhou Medical University, 150 Ximen Street, Linhai, Zhejiang Province, 317000, China","Fang, Y., 2019-nCoV Investigating and Research Team, Department of Radiology, Affiliated Taizhou Hospital of Wenzhou Medical University, 150 Ximen Street, Linhai, Zhejiang Province, 317000, China; Zhang, H., 2019-nCoV Investigating and Research Team, Department of Radiology, Affiliated Taizhou Hospital of Wenzhou Medical University, 150 Ximen Street, Linhai, Zhejiang Province, 317000, China; Xu, Y., 2019-nCoV Investigating and Research Team, Department of Radiology, Affiliated Taizhou Hospital of Wenzhou Medical University, 150 Ximen Street, Linhai, Zhejiang Province, 317000, China; Xie, J., 2019-nCoV Investigating and Research Team, Department of Radiology, Affiliated Taizhou Hospital of Wenzhou Medical University, 150 Ximen Street, Linhai, Zhejiang Province, 317000, China; Pang, P., 2019-nCoV Investigating and Research Team, Department of Radiology, Affiliated Taizhou Hospital of Wenzhou Medical University, 150 Ximen Street, Linhai, Zhejiang Province, 317000, China; Ji, W., 2019-nCoV Investigating and Research Team, Department of Radiology, Affiliated Taizhou Hospital of Wenzhou Medical University, 150 Ximen Street, Linhai, Zhejiang Province, 317000, China",[No abstract available],,"interleukin 6; COVID-19; severe acute respiratory syndrome coronavirus 2; adult; bronchiectasis; case report; clinical article; clinical feature; computer assisted tomography; coronavirus disease 2019; Coronavirus infection; coughing; erythrocyte sedimentation rate; female; fever; human; lymphocyte; male; middle aged; neutrophil; Note; pleura thickening; priority journal; real time polymerase chain reaction; virus pneumonia; abnormal respiratory sound; Betacoronavirus; China; complication; Coronavirus infection; coughing; diagnostic imaging; disease exacerbation; fever; isolation and purification; lung; pathology; virus pneumonia; x-ray computed tomography; Adult; Betacoronavirus; China; Coronavirus Infections; Cough; Disease Progression; Female; Fever; Humans; Lung; Male; Middle Aged; Pneumonia, Viral; Real-Time Polymerase Chain Reaction; Respiratory Sounds; Tomography, X-Ray Computed","Holshue, M.L., DeBolt, C., Lindquist, S., First case of 2019 novel coronavirus in the United States N Engl J Med, , Published online January 31, 2020; Li, Q., Guan, X., Wu, P., Wang, X., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia N Engl J Med, , Published online January 29, 2020; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Lancet, , Published online January 24, 2020; Lei, J., Li, J., Li, X., Qi, X., CT imaging of the 2019 novel coronavirus (2019-NCoV) pneumonia (2020) Radiology, 295, p. 18; Chung, M., Bernheim, A., Mei, X., CT imaging features of 2019 novel coronavirus (2019-nCoV) (2020) Radiology, 295, pp. 202-207; Song, F., Shi, N., Shan, F., Emerging 2019 novel coronavirus (2019-nCoV) pneumonia (2020) Radiology, 295, pp. 210-217","Ji, W.; 2019-nCoV Investigating and Research Team, Department of Radiology, Affiliated Taizhou Hospital of Wenzhou Medical University, 150 Ximen Street, China; email: 1224190004@qq.com",,Radiological Society of North America Inc.,338419,,RADLA,32031481,English,Radiology,Note,Final,Open Access,Scopus,2-s2.0-85080030605,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "McCarty M.F., DiNicolantonio J.J.",24435224500;54414004900;,Nutraceuticals have potential for boosting the type 1 interferon response to RNA viruses including influenza and coronavirus,2020,Progress in Cardiovascular Diseases,,,,,,,,10.1016/j.pcad.2020.02.007,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079862410&doi=10.1016%2fj.pcad.2020.02.007&partnerID=40&md5=bd92f3e2d3716dc8b9e1dd1633247b59,"Catalytic Longevity Foundation, United States; Mid America Heart Institute, St. Luke's Hospital, United States","McCarty, M.F., Catalytic Longevity Foundation, United States; DiNicolantonio, J.J., Mid America Heart Institute, St. Luke's Hospital, United States",[No abstract available],,,"Diebold, S.S., Kaisho, T., Hemmi, H., Akira, S., Reis e Sousa, C., Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA (2004) Science, 303 (5663), pp. 1529-1531; To, E.E., Vlahos, R., Luong, R., Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy (2017) Nat Commun, 8 (1), p. 69; Lanone, S., Bloc, S., Foresti, R., Bilirubin decreases nos2 expression via inhibition of NAD(P)H oxidase: implications for protection against endotoxic shock in rats (2005) FASEB J, 19 (13), pp. 1890-1892; Datla, S.R., Dusting, G.J., Mori, T.A., Taylor, C.J., Croft, K.D., Jiang, F., Induction of heme oxygenase-1 in vivo suppresses NADPH oxidase derived oxidative stress (2007) Hypertension, 50 (4), pp. 636-642; Lehmann, E., El-Tantawy, W.H., Ocker, M., The heme oxygenase 1 product biliverdin interferes with hepatitis C virus replication by increasing antiviral interferon response (2010) Hepatology, 51 (2), pp. 398-404; Ma, L.L., Zhang, P., Wang, H.Q., Heme oxygenase-1 agonist CoPP suppresses influenza virus replication through IRF3-mediated generation of IFN-alpha/beta (2019) Virology, 528, pp. 80-88; Ma, Z.C., Hong, Q., Wang, Y.G., Ferulic acid induces heme oxygenase-1 via activation of ERK and Nrf2 (2011) Drug Discov Ther, 5 (6), pp. 299-305; Ogborne, R.M., Rushworth, S.A., O'Connell, M.A., Alpha-lipoic acid-induced heme oxygenase-1 expression is mediated by nuclear factor erythroid 2-related factor 2 and p38 mitogen-activated protein kinase in human monocytic cells (2005) Arterioscler Thromb Vasc Biol, 25 (10), pp. 2100-2105; Yu, J.S., Chen, W.C., Tseng, C.K., Sulforaphane suppresses hepatitis C virus replication by up-regulating heme oxygenase-1 expression through PI3K/Nrf2 pathway (2016) PLoS One, 11 (3); Zhu, Y., Shao, Y., Qu, X., Sodium ferulate protects against influenza virus infection by activation of the TLR7/9-MyD88-IRF7 signaling pathway and inhibition of the NF-kappaB signaling pathway (2019) Biochem Biophys Res Commun, 512 (4), pp. 793-798; McCarty, M.F., Clinical potential of Spirulina as a source of phycocyanobilin (2007) J Med Food, 10 (4), pp. 566-570; Zheng, J., Inoguchi, T., Sasaki, S., Phycocyanin and phycocyanobilin from Spirulina platensis protect against diabetic nephropathy by inhibiting oxidative stress (2013) Am J Physiol Regul Integr Comp Physiol, 304 (2), pp. R110-R120; Romay, C., Gonzalez, R., Ledon, N., Remirez, D., Rimbau, V., C-phycocyanin: a biliprotein with antioxidant, anti-inflammatory and neuroprotective effects (2003) Curr Protein Pept Sci, 4 (3), pp. 207-216; Chen, Y.H., Chang, G.K., Kuo, S.M., Well-tolerated Spirulina extract inhibits influenza virus replication and reduces virus-induced mortality (2016) Sci Rep, 6; Surh, Y.J., Kundu, J.K., Na, H.K., Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals (2008) Planta Med, 74 (13), pp. 1526-1539; Ungheri, D., Pisani, C., Sanson, G., Protective effect of n-acetylcysteine in a model of influenza infection in mice (2000) Int J Immunopathol Pharmacol, 13 (3), pp. 123-128; Ghezzi, P., Ungheri, D., Synergistic combination of N-acetylcysteine and ribavirin to protect from lethal influenza viral infection in a mouse model (2004) Int J Immunopathol Pharmacol, 17 (1), pp. 99-102; Garozzo, A., Tempera, G., Ungheri, D., Timpanaro, R., Castro, A., N-acetylcysteine synergizes with oseltamivir in protecting mice from lethal influenza infection (2007) Int J Immunopathol Pharmacol, 20 (2), pp. 349-354; De, F.S., Grassi, C., Carati, L., Attenuation of influenza-like symptomatology and improvement of cell-mediated immunity with long-term N-acetylcysteine treatment (1997) Eur Respir J, 10 (7), pp. 1535-1541; McCarty, M.F., DiNicolantonio, J.J., An increased need for dietary cysteine in support of glutathione synthesis may underlie the increased risk for mortality associated with low protein intake in the elderly (2015) Age (Dordr), 37 (5), p. 96; Luo, X.M., Wei, H.J., Yang, C.L., Selenium intake and metabolic balance of 10 men from a low selenium area of China (1985) Am J Clin Nutr, 42 (1), pp. 31-37; Nelson, H.K., Shi, Q., Van, D.P., Host nutritional selenium status as a driving force for influenza virus mutations (2001) FASEB J, 15 (10), pp. 1846-1848; Prasad, A.S., Beck, F.W., Bao, B., Zinc supplementation decreases incidence of infections in the elderly: effect of zinc on generation of cytokines and oxidative stress (2007) Am J Clin Nutr, 85 (3), pp. 837-844; To, E.E., Luong, R., Diao, J., Novel endosomal NOX2 oxidase inhibitor ameliorates pandemic influenza A virus-induced lung inflammation in mice (2019) Respirology, 24 (10), pp. 1011-1017; Huang, B., Li, J., Zhang, X., Zhao, Q., Lu, M., Lv, Y., RIG-1 and MDA-5 signaling pathways contribute to IFN-beta production and viral replication in porcine circovirus virus type 2-infected PK-15 cells in vitro (2017) Vet Microbiol, 211, pp. 36-42; Kawai, T., Sato, S., Ishii, K.J., Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6 (2004) Nat Immunol, 5 (10), pp. 1061-1068; Ye, J.S., Kim, N., Lee, K.J., Nam, Y.R., Lee, U., Joo, C.H., Lysine 63-linked TANK-binding kinase 1 ubiquitination by mindbomb E3 ubiquitin protein ligase 2 is mediated by the mitochondrial antiviral signaling protein (2014) J Virol, 88 (21), pp. 12765-12776; Zhu, W., Li, J., Zhang, R., TRAF3IP3 mediates the recruitment of TRAF3 to MAVS for antiviral innate immunity (2019) EMBO J, 38 (18); Song, N., Qi, Q., Cao, R., MAVS O-GlcNAcylation is essential for host antiviral immunity against lethal RNA viruses (2019) Cell Rep, 28 (9), pp. 2386-2396; McCarty, M.F., O'Keefe, J.H., DiNicolantonio, J.J., Glucosamine for the treatment of osteoarthritis: the time has come for higher-dose trials (2019) J Diet Suppl, 16 (2), pp. 179-192; Katoh, A., Kai, H., Harada, H., Niiyama, H., Ikeda, H., Oral administration of glucosamine improves vascular endothelial function by modulating intracellular redox state (2017) Int Heart J, 58 (6), pp. 926-932; McCarty, M.F., O'Keefe, J.H., DiNicolantonio, J.J., Glucosamine for the treatment of osteoarthritis: the time has come for higher-dose trials (2019) J Diet Suppl, 16 (2), pp. 179-192; Vetvicka, V., Vannucci, L., Sima, P., Richter, J., Beta glucan: supplement or drug? From laboratory to clinical trials (2019) Molecules, 30, p. 24(7); Vetvicka, V., Vetvickova, J., Glucan supplementation enhances the immune response against an influenza challenge in mice (2015) Ann Transl Med, 3 (2), p. 22; Bao, B., Prasad, A.S., Beck, F.W., Zinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: a potential implication of zinc as an atheroprotective agent (2010) Am J Clin Nutr, 91 (6), pp. 1634-1641; Clemons, T.E., Kurinij, N., Sperduto, R.D., Associations of mortality with ocular disorders and an intervention of high-dose antioxidants and zinc in the Age-Related Eye Disease Study: AREDS Report No. 13 (2004) Arch Ophthalmol, 122 (5), pp. 716-726; Leung, P.C., The efficacy of Chinese medicine for SARS: a review of Chinese publications after the crisis (2007) Am J Chin Med, 35 (4), pp. 575-581; Hawkins, J., Baker, C., Cherry, L., Dunne, E., Black elderberry (Sambucus nigra) supplementation effectively treats upper respiratory symptoms: a meta-analysis of randomized, controlled clinical trials (2019) Complement Ther Med, 42, pp. 361-365; McCarty, M.F., Assanga, S.B.I., Ferulic acid may target MyD88-mediated pro-inflammatory signaling — implications for the health protection afforded by whole grains, anthocyanins, and coffee (2018) Med Hypotheses, 118, pp. 114-120","DiNicolantonio, J.J.; Mid America Heart Institute, St. Luke's HospitalUnited States; email: jjdinicol@gmail.com",,W.B. Saunders,330620,,PCVDA,32061635,English,Prog. Cardiovasc. Dis.,Note,Article in Press,Open Access,Scopus,2-s2.0-85079862410,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Xu X., Yu C., Zhang L., Luo L., Liu J.",57215087553;57215089397;57215090616;9039575200;24401436200;,Imaging features of 2019 novel coronavirus pneumonia,2020,European Journal of Nuclear Medicine and Molecular Imaging,47,5,,1022,1023,,1,10.1007/s00259-020-04720-2,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079850063&doi=10.1007%2fs00259-020-04720-2&partnerID=40&md5=6cc3af6246276e76e03b04ce17c135a2,"Department of Medical Imaging Center, the First Affiliated Hospital, Jinan University, No. 613, Huangpu Road West, Tianhe District, Guangzhou, 510630, China; Department of Radiology, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, No. 8, Huaying Road, Baiyun District, Guangzhou, Guangdong Province 510060, China","Xu, X., Department of Medical Imaging Center, the First Affiliated Hospital, Jinan University, No. 613, Huangpu Road West, Tianhe District, Guangzhou, 510630, China; Yu, C., Department of Radiology, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, No. 8, Huaying Road, Baiyun District, Guangzhou, Guangdong Province 510060, China; Zhang, L., Department of Radiology, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, No. 8, Huaying Road, Baiyun District, Guangzhou, Guangdong Province 510060, China; Luo, L., Department of Medical Imaging Center, the First Affiliated Hospital, Jinan University, No. 613, Huangpu Road West, Tianhe District, Guangzhou, 510630, China; Liu, J., Department of Radiology, Guangzhou Eighth People’s Hospital, Guangzhou Medical University, No. 8, Huaying Road, Baiyun District, Guangzhou, Guangdong Province 510060, China",[No abstract available],,,"Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., A novel coronavirus from patients with pneumonia in China, 2019 [J] (2020) N Engl J Med, , https://doi.org/10.1056/NEJMoa2001017; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan (2020) Lancet, , https://doi.org/10.1016/S0140-6736(20)30183-5, China [J]","Luo, L.; Department of Medical Imaging Center, the First Affiliated Hospital, Jinan University, No. 613, Huangpu Road West, Tianhe District, China; email: tluolp@jnu.edu.cn",,Springer,16197070,,EJNMA,32060619,English,Eur. J. Nucl. Med. Mol. Imaging,Letter,Final,Open Access,Scopus,2-s2.0-85079850063,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Khan S., Nabi G., Han G., Siddique R., Lian S., Shi H., Bashir N., Ali A., Shereen M.A.",57192387486;57189842203;57215080868;57192396029;57215085960;57215082337;57212668641;57213370320;57212456485;,Novel coronavirus: how things are in Wuhan,2020,Clinical Microbiology and Infection,,,,,,,2,10.1016/j.cmi.2020.02.005,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079845136&doi=10.1016%2fj.cmi.2020.02.005&partnerID=40&md5=8a601facdd15cb5dcc2632280ac5393d,"Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Henan Medical Key Laboratory of Translational Cerebrovascular Diseases, Zhengzhou, China; Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei Province, College of Life Sciences, Hebei Normal University, Shijiazhuang, China; Department of Radiation Oncology, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Oncology, Renmin Hospital of Wuhan, Wuhan University, Wuhan, China; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China; Wuhan Institute of Virology, Chinese Academy of Sciences Xiao Hong Shan, No. 44, Wuhan, China; The University of Chinese Academy of Sciences, Beijing, 100049, China","Khan, S., Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China, Henan Medical Key Laboratory of Translational Cerebrovascular Diseases, Zhengzhou, China; Nabi, G., Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei Province, College of Life Sciences, Hebei Normal University, Shijiazhuang, China; Han, G., Department of Radiation Oncology, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Siddique, R., Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China, Henan Medical Key Laboratory of Translational Cerebrovascular Diseases, Zhengzhou, China; Lian, S., Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Shi, H., Department of Radiation Oncology, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, Department of Oncology, Renmin Hospital of Wuhan, Wuhan University, Wuhan, China; Bashir, N., State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China; Ali, A., Wuhan Institute of Virology, Chinese Academy of Sciences Xiao Hong Shan, No. 44, Wuhan, China, The University of Chinese Academy of Sciences, Beijing, 100049, China; Shereen, M.A., State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China",[No abstract available],,,"Hui, D.S., Azhar, E., Madani, T.A., Ntoumi, F., Kock, R., Dar, O., The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health – The latest 2019 novel coronavirus outbreak in Wuhan, China (2020) Int J Infect Dis, 91, pp. 264-266; Zhou, C., Zhen, L., Wu, W., Yan, A., Pinghui, Z., Coronavirus claims first life outside China as Wuhan enforces quarantine for all suspected patients (2020), https://www.scmp.com/news/china/society/article/3048575/; Ma, J., Zheng, W., Lau, M., China coronavirus: Wuhan medical staff being infected at much faster pace than reported as national death toll hits 26 (2020), https://www.scmp.com/news/china/society/article/3047441/; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 6736, pp. 1-10; Jia, C., Wuhan calls for more material help to deal with virus (2020), https://www.chinadaily.com.cn/a/202001/25/WS5e2c2b0da31012821727338e.html, Daily China; Young, J., Dramatic Hong Kong data predicts coronavirus outbreak infecting 150,000 every day (2020), https://www.ccn.com; BBC. Coronavirus, China building two hospitals in just a few days to tackle virus (2020), https://www.bbc.co.uk/newsround/51285450; Chen, Y., Liu, Q., Guo, D., Coronaviruses: genome structure, replication, and pathogenesis (2020) J Med Virol, , 0–2; Huang, J., Health workers in Wuhan under growing risk as medical supplies run low (2020), https://www.voanews.com/science-health/coronavirus-outbreak/","Khan, S.; The Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou UniversityChina; email: Suliman.khan18@mails.ucas.ac.cn",,Elsevier B.V.,1198743X,,CMINF,32058086,English,Clin. Microbiol. Infect.,Note,Article in Press,Open Access,Scopus,2-s2.0-85079845136,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Sabino-Silva R., Jardim A.C.G., Siqueira W.L.",26030562800;15769632600;14629566300;,Coronavirus COVID-19 impacts to dentistry and potential salivary diagnosis,2020,Clinical Oral Investigations,,,,,,,,10.1007/s00784-020-03248-x,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079789964&doi=10.1007%2fs00784-020-03248-x&partnerID=40&md5=de34af39836973c4d51065c9dcbc3dda,"College of Dentistry, University of Saskatchewan, Saskatoon, SK, Canada; Department of Physiology, Institute of Biomedical Sciences, Federal University of Uberlandia, Uberlandia, Minas Gerais, Brazil; Laboratory of Virology, Institute of Biomedical Sciences, Federal University of Uberlandia, Uberlandia, Minas Gerais, Brazil","Sabino-Silva, R., College of Dentistry, University of Saskatchewan, Saskatoon, SK, Canada, Department of Physiology, Institute of Biomedical Sciences, Federal University of Uberlandia, Uberlandia, Minas Gerais, Brazil; Jardim, A.C.G., Laboratory of Virology, Institute of Biomedical Sciences, Federal University of Uberlandia, Uberlandia, Minas Gerais, Brazil; Siqueira, W.L., College of Dentistry, University of Saskatchewan, Saskatoon, SK, Canada",[No abstract available],,,"Emerging understandings of COVID-19 (2020) Lancet., 395 (10221), p. 311; Zhu, N., Zhang, D., Wang, W., China Novel Coronavirus Investigating and Research Team. A novel coronavirus from patients with pneumonia in China (2019) N Engl J Med, , https://doi.org/10.1056/NEJMoa2001017, 2020; Zhou, P., Yang, X.L., Wang, X.G., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature, , (,),.,., https://doi.org/10.1038/s41586-020-2012-7; Ksiazek, T.G., Erdman, D., Goldsmith, C.S., A novel coronavirus associated with severe acute respiratory syndrome (2003) N Engl J Med, 348 (20), pp. 1953-1966; de Groot, R.J., Baker, S.C., Baric, R.S., Brown, C.S., Drosten, C., Enjuanes, L., Fouchier, R.A., Ziebuhr, J., Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group (2013) J Virol, 87 (14), pp. 7790-7792; Hui, D.S.C., Zumla, A., Severe acute respiratory syndrome: historical, epidemiologic, and clinical features (2019) Infect Dis Clin N Am, 33 (4), pp. 869-889; To, K.K., Tsang, O.T., Chik-Yan Yip, C., Consistent detection of 2019 novel coronavirus in saliva (2020) Clin Infect Dis, , https://doi.org/10.1093/cid/ciaa149; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, S0140-6736 (20), pp. 30183-30185; Emergencies preparedness (2020) Response. Pneumonia of Unknown Origin – China Disease Outbreak News, , https://www.who.int/csr/don/12-january-2020-novel-coronavirus-china/en/, 12 January, Accessed 12 Jan 2020, Available at; Wu, A., Peng, Y., Huang, B., Genome composition and divergence of the novel coronavirus (COVID-19) originating in China (2020) Cell Host Microbe, S1931–3128 (20); Shu, Y., McCauley, J., GISAID: global initiative on sharing all influenza data - from vision to reality (2017) Euro Surveill, 22 (13). , (,),., (,)., https://doi.org/10.2807/1560-7917.ES.2017.22.13.30494; (2020) European Surveillance for Human Infection with Novel Coronavirus (COVID-19), , https://www.ecdc.europa.eu/en/european-surveillance-human-infection-novel-coronavirus-COVID-19, 22 January, Accessed 28 Jan; (2020) Global Surveillance for Human Infection with Novel Coronavirus (COVID-19) Interim Guidance, , https://www.who.int/docs/default-source/coronaviruse/20200121-global-surveillance-for-COVID-19.pdf, 21 January, Accessed 28 Jan 2020, Available at; Xie, X., Li, Y., Sun, H., Liu, L., Exhaled droplets due to talking and coughing (2009) J R Soc Interface, 6, pp. S703-S714; Chan, J.F., Yuan, S., Kok, K.H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: A study of a family cluster (2020) Lancet, , https://doi.org/10.1016/S0140-6736(20)30154-9; Wang, D., Hu, B., Hu, C., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) JAMA, , (,),.,., https://doi.org/10.1001/jama.2020.1585; (2020) Expert consensus for bronchoscopy during the epidemic of 2019 Novel Coronavirus infection, 43, p. E006. , https://doi.org/10.3760/cma.j.issn.1001-0939.2020.0006, Trial version; Barzon, L., Pacenti, M., Berto, A., Sinigaglia, A., Franchin, E., Lavezzo, E., Brugnaro, P., Palù, G., Isolation of infectious Zika virus from saliva and prolonged viral RNA shedding in a traveller returning from the Dominican Republic to Italy, January 2016 (2016) Euro Surveill, 21 (10), p. 30159; Zuanazzi, D., Arts, E.J., Jorge, P.K., Mulyar, Y., Gibson, R., Xiao, Y., Bringel Dos Santos, M., Siqueira, W.L., Postnatal identification of zika virus peptides from saliva (2017) J Dent Res, 96 (10), pp. 1078-1084; Segal, A., Wong, D.T., Salivary diagnostics: enhancing disease detection and making medicine better (2008) Eur J Dent Educ, 12, pp. 22-29; Silva-Boghossian, C.M., Colombo, A.P., Tanaka, M., Quantitative proteomic analysis of gingival crevicular fluid in different periodontal conditions (2013) PLoS One, 8 (10); Liu, L., Wei, Q., Alvarez, X., Epithelial cells lining salivary gland ducts are early target cells of severe acute respiratory syndrome coronavirus infection in the upper respiratory tracts of rhesus macaques (2011) J Virol, 85 (8), pp. 4025-4030; Lu, B., Huang, Y., Huang, L., Li, B., Zheng, Z., Chen, Z., Chen, J., Wang, H., Effect of mucosal and systemic immunization with virus-like particles of severe acute respiratory syndrome coronavirus in mice (2010) Immunology., 130 (2), pp. 254-261","Siqueira, W.L.; College of Dentistry, University of SaskatchewanCanada; email: walter.siqueira@usask.ca",,Springer,14326981,,,,English,Clin. Oral Invest.,Letter,Article in Press,Open Access,Scopus,2-s2.0-85079789964,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Qiu H., Tong Z., Ma P., Hu M., Peng Z., Wu W., Du B., China Critical Care Clinical Trials Group (CCCCTG)",57208558416;57215047030;57215684649;57215056088;57214776125;57214756457;57202638063;,Intensive care during the coronavirus epidemic,2020,Intensive Care Medicine,46,4,,576,578,,2,10.1007/s00134-020-05966-y,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079771160&doi=10.1007%2fs00134-020-05966-y&partnerID=40&md5=42807021a1e7bee2e1398b70db8d40a0,"Department of Critical Care Medicine, Zhongda Hospital, Southeast University, Nanjing, Jiangsu, China; Department of Pulmonary and Critical Care Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Department of Critical Care Medicine, Peking University Third Hospital, Beijing, China; Department of Critical Care Medicine, Wuhan Pulmonary Hospital, Wuhan, Hubei, China; Department of Critical Care Medicine, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, China; Department of Critical Care Medicine, Wuhan Jinyintan Hospital, Wuhan, Hubei, China; Medical ICU, Peking Union Medical College Hospital, 1 Shuai Fu Yuan, Beijing, 100730, China","Qiu, H., Department of Critical Care Medicine, Zhongda Hospital, Southeast University, Nanjing, Jiangsu, China; Tong, Z., Department of Pulmonary and Critical Care Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China; Ma, P., Department of Critical Care Medicine, Peking University Third Hospital, Beijing, China; Hu, M., Department of Critical Care Medicine, Wuhan Pulmonary Hospital, Wuhan, Hubei, China; Peng, Z., Department of Critical Care Medicine, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, China; Wu, W., Department of Critical Care Medicine, Wuhan Jinyintan Hospital, Wuhan, Hubei, China; Du, B., Medical ICU, Peking Union Medical College Hospital, 1 Shuai Fu Yuan, Beijing, 100730, China; China Critical Care Clinical Trials Group (CCCCTG)",[No abstract available],,,"Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395 (10223), pp. 497-506; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395 (10223), pp. 507-513; (2020), https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200204-sitrep-15-ncov.pdf?sfvrsn=88fe8ad6_2, Novel coronavirus (2019-nCoV) Situation report—15, 4 February, Accessed 5 February 2020; Devereaux, A., Christian, M.D., Dichter, J.R., Summary of suggestions from the task force for mass critical care summit meeting, January 26–27, 2007 (2008) Chest, 133, pp. 1S-7S; Christian, M.D., Devereaux, A.V., Dichter, J.R., Definitive care for the critically ill during a disaster: current capabilities and limitations. From a task force for mass critical care summit meeting, January 26–27, 2007, Chicago IL (2008) Chest, 133, pp. 8S-17S; Rubinson, L., Hick, J.L., Hanfling, D.G., Definitive care for the critically ill during a disaster: a framework for optimizing critical care surge capacity. from a task force for mass critical care summit meeting, January 26–27, 2007, Chicago IL (2008) Chest, 133, pp. 18S-31S; Infection Prevention and Control during Health Care When Novel Coronavirus (Ncov) Infection is Suspected, , https://apps.who.int/iris/rest/bitstreams/1266296/retrieve, Interim guidance 25 January 2020, Accessed 5 February 2020; Liao, X., Wang, B., Kang, Y., Novel coronavirus infection during the 2019–2020 epidemic: preparing intensive care units-the experience in Sichuan Province, China (2020) Intens Care Med; Ostermann, M., Vincent, J.L., How much centralization of critical care services in the era of telemedicine? (2019) Crit Care, 23, p. 423; Du, B., Xi, X., Kang, Y., Natural disaster (2009) Intensive and critical care medicine, pp. 379-390. , Gullo A, Besso J, Lumb PD, Williams GF, (eds), Springer, Milan","Du, B.; Medical ICU, Peking Union Medical College Hospital, 1 Shuai Fu Yuan, China; email: Dubin98@gmail.com",,Springer,3424642,,ICMED,32077996,English,Intensive Care Med.,Editorial,Final,Open Access,Scopus,2-s2.0-85079771160,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Pan L., Wang L., Huang X.",25927411400;57196341978;55500277100;,How to face the novel coronavirus infection during the 2019–2020 epidemic: the experience of Sichuan Provincial People’s Hospital,2020,Intensive Care Medicine,46,4,,573,575,,1,10.1007/s00134-020-05964-0,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079729411&doi=10.1007%2fs00134-020-05964-0&partnerID=40&md5=e0ff47404ce515d18350d127c0a4b26a,"Department of Critical Care Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China; Department of Hospital Administration, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China; Department of Nephrology, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China","Pan, L., Department of Critical Care Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China; Wang, L., Department of Hospital Administration, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China, Department of Nephrology, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China; Huang, X., Department of Critical Care Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China",[No abstract available],,,"Huang, C.L., Wang, Y., Li, X.W., (2020) Clinical features of patients infected with 2019 novel coronavirus in Wuhan. Lancet, China, , https://doi.org/10.1016/S0140-6736(20)30183-5","Pan, L.; Department of Critical Care Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of ChinaChina; email: panlingai2004@163.com",,Springer,3424642,,ICMED,32072300,English,Intensive Care Med.,Editorial,Final,Open Access,Scopus,2-s2.0-85079729411,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wei M., Yuan J., Liu Y., Fu T., Yu X., Zhang Z.-J.",57191754436;7403401685;57215006369;57215006544;57214994328;56068578400;,Novel Coronavirus Infection in Hospitalized Infants under 1 Year of Age in China,2020,JAMA - Journal of the American Medical Association,,,,,,,11,10.1001/jama.2020.2131,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079695722&doi=10.1001%2fjama.2020.2131&partnerID=40&md5=1baa8fbca64b2718a381bffbc28253e7,"Renmin Hospital of Wuhan University, Wuhan, China; School of Management, Wuhan Institute of Technology, Wuhan, China; School of Health Sciences, Wuhan University, Wuhan, China","Wei, M., Renmin Hospital of Wuhan University, Wuhan, China; Yuan, J., Renmin Hospital of Wuhan University, Wuhan, China; Liu, Y., School of Management, Wuhan Institute of Technology, Wuhan, China; Fu, T., Renmin Hospital of Wuhan University, Wuhan, China; Yu, X., School of Health Sciences, Wuhan University, Wuhan, China; Zhang, Z.-J., School of Health Sciences, Wuhan University, Wuhan, China",[No abstract available],,,"Paules, C.I., Marston, H.D., Fauci, A.S., Coronavirus infections-more than just the common cold (2020) Jama, , http://jamanetwork.com/article.aspx?doi=10.1001/jama.2020.0757, [published online January 23,].. doi: PMID 31971553; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study (2020) Lancet, , http://dx.doi.org/10.1016/S0140-6736(20)30211-7, [published online January 30,].. doi: PMID 32007143; Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan (2020) Jama, , http://jamanetwork.com/article.aspx?doi=10.1001/jama.2020.1585, [published online February 7,].. doi: PMID 32031570; Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med, , http://dx.doi.org/10.1056/NEJMoa2001316, [published online January 29,]. doi: PMID 31995857; Del Rio, C., Malani, P.N., 2019 Novel coronavirus-important information for clinicians (2020) Jama, , http://jamanetwork.com/article.aspx?doi=10.1001/jama.2020.1490, [published online February 5,].. doi: PMID 32022836","Zhang, Z.-J.; Department of Preventive Medicine, School of Health Sciences, Wuhan University, No. 185 Donghu Rd, China; email: zhang22968@163.com",,American Medical Association,987484,,JAMAA,32058570,English,JAMA,Letter,Article in Press,Open Access,Scopus,2-s2.0-85079695722,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Gostin L.O., Hodge J.G., Jr",7102748505;23100107300;,US Emergency Legal Responses to Novel Coronavirus: Balancing Public Health and Civil Liberties,2020,JAMA - Journal of the American Medical Association,323,12,,1131,1132,,,10.1001/jama.2020.2025,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079650488&doi=10.1001%2fjama.2020.2025&partnerID=40&md5=c26c3705c724a86193c7f15ee733ae42,"O'Neill Institute for National, Global Health Law, Georgetown University Law Center, Washington, DC, United States; Center for Public Health Law and Policy, Sandra Day o'Connor College of Law, Arizona State University, Phoenix, United States","Gostin, L.O., O'Neill Institute for National, Global Health Law, Georgetown University Law Center, Washington, DC, United States; Hodge, J.G., Jr, Center for Public Health Law and Policy, Sandra Day o'Connor College of Law, Arizona State University, Phoenix, United States",[No abstract available],,,"https://www.phe.gov/emergency/news/healthactions/phe/Pages/2019-nCoV.aspx, Determination that a public health emergency exists. Published January 31, 2020. Accessed February 3, 2020; Del Rio, C., Malani, P.N., 2019 Novel coronavirus - Important information for clinicians JAMA, , http://jamanetwork.com/article.aspx?doi=10.1001/jama.2020.1490, [published February 5, 2020].. doi; Hanfling, D., Altevogt, B.M., Gostin, L.O., A framework for catastrophic disaster response (2012) JAMA, 308 (7), pp. 675-676. , http://jamanetwork.com/article.aspx?doi=10.1001/jama.2012.8171, doi: 22893162; https://www.whitehouse.gov/presidential-actions/proclamation-suspension-entry-immigrants-nonimmigrants-persons-pose-risk-transmitting-2019-novel-coronavirus/, Proclamation on suspension of entry as immigrants and nonimmigrants of persons who pose a risk of transmitting 2019 novel coronavirus. Published January 31, 2020. Accessed February 3, 2020; https://travel.state.gov/content/travel/en/traveladvisories/traveladvisories/china-travel-advisory.html, China travel advisory. Published February 2, 2020. Accessed February 3, 2020; Seck, H.H., https://www.military.com/daily-news/2020/02/01/4-more-military-bases-tapped-house-coronavirus-evacuees.html, 4 More military bases tapped to house coronavirus evacuees. Published February 1, 2020. Accessed February 3, 2020; Public Health Services Act, 42 USC §6A (2016); Gostin, L.O., Hodge, J.G., Jr., Reforming federal public health powers: Responding to national and global threats (2017) JAMA, 317 (12), pp. 1211-1212. , http://jamanetwork.com/article.aspx?doi=10.1001/jama.2017.1021, doi: 28208169","Gostin, L.O.; Georgetown University Law Center, 600 New Jersey Ave NW, McDonough 568, United States; email: gostin@law.georgetown.edu",,American Medical Association,987484,,JAMAA,32053150,English,JAMA,Note,Final,Open Access,Scopus,2-s2.0-85079650488,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Shen K.-L., Yang Y.-H.",55641765700;57214917579;,Diagnosis and treatment of 2019 novel coronavirus infection in children: a pressing issue,2020,World Journal of Pediatrics,,,,,,,1,10.1007/s12519-020-00344-6,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079501279&doi=10.1007%2fs12519-020-00344-6&partnerID=40&md5=b8ec15e51d80682a1d31b793b8d2fe57,"China National Clinical Research Center for Respiratory Diseases, Beijing, China; Department of Respiratory Medicine, Beijing Children’s Hospital, Capital Medical University, Beijing, China; National Center for Children’s Health, Beijing, China; Beijing Pediatric Reasearch Institute, Beijing, China","Shen, K.-L., China National Clinical Research Center for Respiratory Diseases, Beijing, China, Department of Respiratory Medicine, Beijing Children’s Hospital, Capital Medical University, Beijing, China, National Center for Children’s Health, Beijing, China; Yang, Y.-H., China National Clinical Research Center for Respiratory Diseases, Beijing, China, National Center for Children’s Health, Beijing, China, Beijing Pediatric Reasearch Institute, Beijing, China",[No abstract available],,,"https://www.nhc.gov.cn/xcs/yqfkdt/202001/a53e6df293cc4ff0b5a16ddf7b6b2b31.shtml, National Health Commission of People’s Republic of China, Accessed 30 Jan 2020; Li, Z.Z., Shen, K.L., Wei, X.M., Wang, H.L., Lu, J., Tian, H., Clinical analysis of pediatric SARS cases in Beijing (2003) Chin J Pediatr, 41, pp. 574-577. , (in Chinese; Yang, Y.H., Concern for severe acute respiratory syndrome (2003) Chin J Pediatr, 41, pp. 401-402. , (in Chinese; Merigan, T.C., Reed, S.E., Hall, T.S., Tyrrell, D.A., Middle East respiratory syndrome coronavirus in children (2015) Saudi Med J, 36, pp. 484-486; Merigan, T.C., Reed, S.E., Hall, T.S., Tyrrell, D.A., Inhibition of respiratory virus infection by locally applied interferon (1973) Lancet, 17, pp. 563-567; Chen, P.L., Zhang, T.X., Hu, Y.H., A multicenter randomized controlled clinical study of recombinant human interferon-typeα1b in the treatment of viral pneumonia in children (2005) Linchuang Erke Zazhi, 23, pp. 244-245. , in Chinese; Shang, Y.X., Huang, Y., Liu, E.M., A multicenter study on the treatment of acute bronchiolitis by nebulized human recombinant human interferon-alpha 1b (2014) Zhongguo Shiyong Erke Zazhi, 29, pp. 840-844. , in Chinese; Xu, Y.L., Tian, Q.L., Jiang, T.Y., Effect of nebulized inhalation of recombinant human interferon alpha-1b on early treatment of severe hand, foot and mouth disease (2015) Zhonghua Shiyong Erke Zazhi, 30, pp. 627-630. , in Chinese; Shen, K.L., Shang, Y.X., Zhang, G.C., Rational use of interferon alpha in pediatrical clinical practice: experts’ consensus statement (2018) Zhonghua Shiyong Erke Zazhi, 33, pp. 1301-1308. , in Chinese; Shen, K.L., Shang, Y.X., Zhang, H., A multicenter, randomized, controlled clinical study on the efficacy and safety of recombinant human interferon 2b spray (pseudomonas) in the treatment of acute upper respiratory tract infection in children (2019) Zhongguo Shiyong Erke Zazhi, 34, pp. 1010-1016. , in Chinese; Gao, H., Zhang, L.L., Qin, C., Experimental study on the prevention and treatment of SARS-CoV infection in rhesus monkeys with recombinant human interferon 2b nasal spray (2005) Chin J Exp Clin Virol, 19, pp. 207-211. , COI: 1:CAS:528:DC%2BD28XhsFCns7w%3D, Chinese; Wang, H.Q., Ma, L.L., Jiang, J.D., Study on the pharmacodynamics of recombinant human interferon alpha 2b against respiratory viruses (2014) Yaoxue Xuebao, 49, pp. 1547-1553. , COI: 1:CAS:528:DC%2BC2MXhtlemsb7M, Chinese; Yu, D.X., Chen, Q., Zhang, L.L., Experimental study of recombinant human interferon 2b aerosol in the prevention of respiratory virus infections such as SARS in human populations (2005) Chin J Exp Clin Virol, 19, pp. 216-219. , COI: 1:CAS:528:DC%2BD28XhsFCns70%3D, Chinese; (2020) Diagnosis and Treatment of Pneumonia Caused by Novel Coronavirus (Trial Version 4), , https://www.nhc.gov.cn/xcs/zhengcwj/202001/4294563ed35b43209b31739bd0785e67/files/7a9309111267475a99d4306962c8bf78.pdf, Accessed 28 Jan 2020","Shen, K.-L.; China National Clinical Research Center for Respiratory DiseasesChina; email: kunlingshen1717@163.com",,Institute of Pediatrics of Zhejiang University,17088569,,,32026147,English,World J. Pediatr.,Editorial,Article in Press,Open Access,Scopus,2-s2.0-85079501279,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wax R.S., Christian M.D.",6603778962;7102667580;,Practical recommendations for critical care and anesthesiology teams caring for novel coronavirus (2019-nCoV) patients [Directives concrètes à l’intention des équipes de soins intensifs et d’anesthésiologie prenant soin de patients atteints du coronavirus 2019-nCoV],2020,Canadian Journal of Anesthesia,,,,,,,12,10.1007/s12630-020-01591-x,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079496754&doi=10.1007%2fs12630-020-01591-x&partnerID=40&md5=7daf22ee152c1be95eb3bc2c89d2debc,"Department of Critical Care Medicine, Faculty of Health Sciences, Queen’s University, Kingston, ON, Canada; Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, ON, Canada; London’s Air Ambulance, Royal London Hospital, Barts Health NHS Trust, London, United Kingdom; Department of Critical Care Medicine, Lakeridge Health, 1 Hospital Court, Oshawa, ON L1G 2B9, Canada","Wax, R.S., Department of Critical Care Medicine, Faculty of Health Sciences, Queen’s University, Kingston, ON, Canada, Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, ON, Canada, Department of Critical Care Medicine, Lakeridge Health, 1 Hospital Court, Oshawa, ON L1G 2B9, Canada; Christian, M.D., London’s Air Ambulance, Royal London Hospital, Barts Health NHS Trust, London, United Kingdom","A global health emergency has been declared by the World Health Organization as the 2019-nCoV outbreak spreads across the world, with confirmed patients in Canada. Patients infected with 2019-nCoV are at risk for developing respiratory failure and requiring admission to critical care units. While providing optimal treatment for these patients, careful execution of infection control measures is necessary to prevent nosocomial transmission to other patients and to healthcare workers providing care. Although the exact mechanisms of transmission are currently unclear, human-to-human transmission can occur, and the risk of airborne spread during aerosol-generating medical procedures remains a concern in specific circumstances. This paper summarizes important considerations regarding patient screening, environmental controls, personal protective equipment, resuscitation measures (including intubation), and critical care unit operations planning as we prepare for the possibility of new imported cases or local outbreaks of 2019-nCoV. Although understanding of the 2019-nCoV virus is evolving, lessons learned from prior infectious disease challenges such as Severe Acute Respiratory Syndrome will hopefully improve our state of readiness regardless of the number of cases we eventually manage in Canada. © 2020, Canadian Anesthesiologists' Society.",COVID-19,,"Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus–infected pneumonia (2020) N Engl J Med; Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med; (2005) Emergency Committee regarding the Outbreak of Novel Coronavirus (2019-Ncov), , https://www.who.int/news-room/detail/30-01-2020-statement-on-the-second-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-outbreak-of-novel-coronavirus-(2019-ncov, Available from, accessed February 2020; Government of Canada Evacuating Canadians from Wuhan, China, , https://www.canada.ca/en/global-affairs/news/2020/02/government-of-canada-evacuating-canadians-from-wuhan-china.html, Available from, accessed February 2020; Lu, R., Zhao, X., Li, J., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet; Yu, I.T., Li, Y., Wong, T.W., Evidence of airborne transmission of the severe acute respiratory syndrome virus (2004) N Engl J Med, 350, pp. 1731-1739. , COI: 1:CAS:528:DC%2BD2cXjt12muro%3D; Scales, D.C., Green, K., Chan, A.K., Illness in intensive care staff after brief exposure to severe acute respiratory syndrome (2003) Emerg Infect Dis, 9, pp. 1205-1210; Muller, M.P., McGeer, A., Febrile respiratory illness in the intensive care unit setting: an infection control perspective (2006) Curr Opin Crit Care, 12, pp. 37-42; Fowler, R.A., Lapinsky, S.E., Hallett, D., Critically ill patients with severe acute respiratory syndrome (2003) JAMA, 290, pp. 367-373; Christian, M.D., Loutfy, M., McDonald, L.C., Possible SARS coronavirus transmission during cardiopulmonary resuscitation (2004) Emerg Infect Dis, 10, pp. 287-293; Zhao, S., Lin, Q., Ran, J., Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: a data-driven analysis in the early phase of the outbreak (2020) Int J Infect Dis; Novel Coronavirus (2019-Ncov), , https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200130-sitrep-10-ncov.pdf?sfvrsn=d0b2e480_2, WHO Bull 2020 - Data as reported by January 30, 2020. Available from, (accessed February 2020); Christian, M.D., Poutanen, S.M., Loutfy, M.R., Muller, M.P., Low, D.E., Severe acute respiratory syndrome (2004) Clin Infect Dis, 38, pp. 1420-1427; Majumder, M.S., Rivers, C., Lofgren, E., Fisman, D., Estimation of MERS-coronavirus reproductive number and case fatality rate for the Spring 2014 Saudi Arabia outbreak: Insights from publicly available data (2014) Plos Curr, , http://currents.plos.org/outbreaks/index.html%3Fp=40801.html, Available from, (accessed February 2020); Warriner, D.R., Three little words (2009) BMJ, 338 (feb10 2), p. b521; Novel Coronavirus (Ncov 2019) Situation as of 07 February 2020, , http://who.maps.arcgis.com/apps/opsdashboard/index.html#/c88e37cfc43b4ed3baf977d77e4a0667, 10:00 (CET). Available from, (accessed February 2020); Rothe, C., Schunk, M., Sothmann, P., Transmission of 2019-nCoV infection from an asymptomatic contact in Germany (2020) N Engl J Med; Kupferschmidt, K., Study claiming new coronavirus can be transmitted by people without symptoms was flawed Science, , https://www.sciencemag.org/news/2020/02/paper-non-symptomatic-patient-transmitting-coronavirus-wrong, (February 3, 2020). Available from, accessed February 2020; Bogoch, I.I., Watts, A., Thomas-Bachli, A., Huber, C., Kraemer, M.U., Khan, K., Potential for global spread of a novel coronavirus from China (2020) J Travel Med; Nkengasong, J., China’s response to a novel coronavirus stands in stark contrast to the 2002 SARS outbreak response (2020) Nat Med; Chan, J.F., Yuan, S., Kok, K.H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet; Brest, M., Wuhan doctor treating coronavirus patients dies after contracting disease Washington Examiner, , https://www.washingtonexaminer.com/news/wuhan-doctor-treating-coronavirus-patients-dies-after-contracting-disease, Available from, accessed February 2020; Buckley, C., Chinese Doctor, Silenced After Warning of Outbreak, Dies From Coronavirus The New York Times, , https://www.nytimes.com/2020/02/06/world/asia/chinese-doctor-Li-Wenliang-coronavirus.html, Available from, accessed February 2020; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet; Interim National Case Definition: Novel Coronavirus (2019-Ncov), , https://www.canada.ca/en/public-health/services/diseases/2019-novel-coronavirus-infection/health-professionals/national-case-definition.html, Available from, (accessed February 2020); McDonald, L.C., Simor, A.E., Su, I.J., SARS in healthcare facilities, Toronto and Taiwan (2004) Emerg Infect Dis, 10, pp. 777-781; Infection Prevention and Control for Novel Coronavirus (2019-Ncov): Interim Guidance for Acute Healthcare Settings, , https://www.canada.ca/en/public-health/services/diseases/2019-novel-coronavirus-infection/health-professionals/interim-guidance-acute-healthcare-settings.html, Available from, (accessed Februay 2020); Novel Coronavirus May Spread via Digestive System: Experts, , http://www.xinhuanet.com/english/2020-02/02/c_138749620.htm, English.news.cn. 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Available from, accessed February 2020; Zamora, J.E., Murdoch, J., Simchison, B., Day, A.G., Contamination: a comparison of 2 personal protective systems (2006) CMAJ, 175, pp. 249-254; Leung, C.C., Joynt, G.M., Gomersall, C.D., Comparison of high-flow nasal cannula versus oxygen face mask for environmental bacterial contamination in critically ill pneumonia patients: a randomized controlled crossover trial (2019) J Hosp Infect, 101, pp. 84-87. , COI: 1:STN:280:DC%2BB3cvgvVaquw%3D%3D; Cheung, T.M., Yam, L.Y., So, L.K., Effectiveness of noninvasive positive pressure ventilation in the treatment of acute respiratory failure in severe acute respiratory syndrome (2004) Chest, 126, pp. 845-850; Gottlieb, M., Holladay, D., Burns, K.M., Nakitende, D., Bailitz, J., Ultrasound for airway management: an evidence-based review for the emergency clinician (2019) Am J Emerg Med; Fan, E., Brodie, D., Slutsky, A.S., Acute respiratory distress syndrome: advances in diagnosis and treatment (2018) JAMA, 319, pp. 698-710; Tien, H.C., Chughtai, T., Jogeklar, A., Cooper, A.B., Brenneman, F., Elective and emergency surgery in patients with severe acute respiratory syndrome (SARS) (2005) Can J Surg, 48, pp. 71-74. , PID: 15757044; Stelfox, H.T., Bates, D.W., Redelmeier, D.A., Safety of Patients Isolated for Infection Control (2003) JAMA, 290, pp. 1899-1905. , COI: 1:CAS:528:DC%2BD3sXotVWktb0%3D; Abrahamson, S.D., Canzian, S., Brunet, F., Using simulation for training and to change protocol during the outbreak of severe acute respiratory syndrome (2005) Crit Care","Wax, R.S.; Department of Critical Care Medicine, Lakeridge Health, 1 Hospital Court, Canada; email: randy.wax@queensu.ca",,Springer,0832610X,,CJOAE,32052373,English,Can. J. Anesth.,Review,Article in Press,Open Access,Scopus,2-s2.0-85079496754,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Jiang S., Xia S., Ying T., Lu L.",56491898300;56410369000;57205480302;55715616400;,A novel coronavirus (2019-nCoV) causing pneumonia-associated respiratory syndrome,2020,Cellular and Molecular Immunology,,,,,,,3,10.1038/s41423-020-0372-4,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079445619&doi=10.1038%2fs41423-020-0372-4&partnerID=40&md5=cb9c6bffdf4c3218519ec346fd68f147,"School of Basic Medical Sciences, Fudan University, 131 Dong An Road, Fuxing Building, Xuhui District, Shanghai, 200032, China","Jiang, S., School of Basic Medical Sciences, Fudan University, 131 Dong An Road, Fuxing Building, Xuhui District, Shanghai, 200032, China; Xia, S., School of Basic Medical Sciences, Fudan University, 131 Dong An Road, Fuxing Building, Xuhui District, Shanghai, 200032, China; Ying, T., School of Basic Medical Sciences, Fudan University, 131 Dong An Road, Fuxing Building, Xuhui District, Shanghai, 200032, China; Lu, L., School of Basic Medical Sciences, Fudan University, 131 Dong An Road, Fuxing Building, Xuhui District, Shanghai, 200032, China",[No abstract available],,,"Jiang, S., Du, L., Shi, Z., An emerging coronavirus causing pneumonia outbreak in Wuhan, China: calling for developing therapeutic and prophylactic strategies (2020) Emerg. Microbes Infect., 9, pp. 275-277. , &; Huang, C., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, , https://doi.org/10.1016/S0140-6736(20)30183-5; Li, Q., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N. Engl. J. Med., , https://doi.org/10.1056/NEJMoa2001316","Jiang, S.; School of Basic Medical Sciences, Fudan University, 131 Dong An Road, Fuxing Building, Xuhui District, China; email: shibojiang@fudan.edu.cn",,Springer Nature,16727681,,,32024976,English,Cell. Mol. Immunol,Note,Article in Press,Open Access,Scopus,2-s2.0-85079445619,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Fürst R., Zündorf I.",7004730295;7004222676;,Again a coronavirus!: Why is there no vaccine up to now? [Schon wieder ein Coronavirus!],2020,Deutsche Apotheker Zeitung,160,5,,,,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079386297&partnerID=40&md5=12e1b04a36e5e8b5ad17342b6b1003eb,"Pharmazeutische Biologie am, Institut für Pharmazeutische Biologie an der Goethe-Universität in Frankfurt am Main, Germany; Institut für Pharmazeutische Biologie, Biozentrum, Max-von-Laue-Straße 9, Frankfurt/Main, 60438, Germany","Fürst, R., Pharmazeutische Biologie am, Institut für Pharmazeutische Biologie an der Goethe-Universität in Frankfurt am Main, Germany; Zündorf, I., Institut für Pharmazeutische Biologie, Biozentrum, Max-von-Laue-Straße 9, Frankfurt/Main, 60438, Germany",[No abstract available],,Coronavirus vaccine; unclassified drug; virus vaccine; Article; Coronavirinae; Coronavirus infection; nonhuman; vaccination,"Song, Z., From SARS to MERS, thrusting coronaviruses into the spotlight (2019) Viruses, 11 (1), p. E59; Robert Koch-Institut (RKI), , www.rki.de, Neuartiges Coronavirus 2019-nCoV; World Health Organizazion (WHO), , www.who.int, Novel Coronavirus 2019-nCoV; National Library of Medicine (NLM) at the National Institutes of Health (NIH), , https://clinicaltrials.gov, gov; CEPI to fund three programmes to develop vaccines against the novel coronavirus, nCoV-2019 (2020) Mitteilung Der Coalition for Epidemic Preparedness Innovations (CEPI) Vom, , https://cepi.net, Januar",,,Deutscher Apotheker Verlag,119857,,DAZEA,,German,Dtsch. Apoth. Ztg.,Article,Final,,Scopus,2-s2.0-85079386297,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, [No author name available],[No author id available],Strategies against the novel coronavirus: Possible applications of the experimental Ebola drug remdesivir are being tested [Strategien gegen das neue Coronavirus],2020,Deutsche Apotheker Zeitung,160,5, S. 37,,,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079365583&partnerID=40&md5=3e743dee0f67822dbb975e15b8bc9580,,,[No abstract available],,remdesivir; drug delivery system; Ebola hemorrhagic fever; Short Survey,"Gilead assessing Ebola drug as possible coronavirus treatment (2020) Meldung Vom, 23. , www.reuters.com, Januar; Paules, C.I., Coronavirus infections-more than just the common cold (2020) JAMA; Sheahan, T.P., Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses (2017) Sci Transl Med, 9 (396), p. eaal3653; Sheahan, T.P., Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV (2020) Nat Commun, 11 (1), p. 222",,,Deutscher Apotheker Verlag,119857,,DAZEA,,German,Dtsch. Apoth. Ztg.,Short Survey,Final,,Scopus,2-s2.0-85079365583,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Chen Z.-M., Fu J.-F., Shu Q.",36631890700;8429908700;57210698907;,New coronavirus: new challenges for pediatricians,2020,World Journal of Pediatrics,,,,,,,1,10.1007/s12519-020-00346-4,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079209680&doi=10.1007%2fs12519-020-00346-4&partnerID=40&md5=8c11afcc5333baa88cea0c0ef0ec778b,"Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children’s Regional Medical Center, Hangzhou, 310052, China","Chen, Z.-M., Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children’s Regional Medical Center, Hangzhou, 310052, China; Fu, J.-F., Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children’s Regional Medical Center, Hangzhou, 310052, China; Shu, Q., Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children’s Regional Medical Center, Hangzhou, 310052, China",[No abstract available],,,"National Recommendations for Diagnosis and Treatment of Pneumonia Caused by 2019-Ncov, , https://www.nhc.gov.cn/xcs/zhengcwj/202001/4294563ed35b43209b31739bd0785e67/files/7a9309111267475a99d4306962c8bf78.pdf, (the 4th edition). National Health Commission and National Administrative Office of Chinese Traditional Medicine, Access 29 Jan 2020; Chen, Z.M., Fu, J.F., Shu, Q., Chen, Y.H., Hua, C.Z., Li, F.B., Diagnosis and treatment recommendations for pediatric respiratory infection caused by the 2019 novel coronavirus (2020) World J Pediatr.","Fu, J.-F.; Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children’s Regional Medical CenterChina; email: fjf68@zju.edu.cn",,Institute of Pediatrics of Zhejiang University,17088569,,,32037473,English,World J. Pediatr.,Editorial,Article in Press,Open Access,Scopus,2-s2.0-85079209680,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Rodríguez-Morales A.J., MacGregor K., Kanagarajah S., Patel D., Schlagenhauf P.",8886801000;57214798130;56720317600;7402238649;7003453274;,Going global – Travel and the 2019 novel coronavirus,2020,Travel Medicine and Infectious Disease,33,,101578,,,,8,10.1016/j.tmaid.2020.101578,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079170254&doi=10.1016%2fj.tmaid.2020.101578&partnerID=40&md5=1e8d9b9ce3106701ea885949c5a21ce3,"Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Risaralda, Pereira, Colombia; Grupo de Investigación Biomedicina, Faculty of Medicine, Fundación Universitaria Autónoma de las Américas, Risaralda, Pereira, 660004, Colombia; National Travel Health Network and Centre (NaTHNaC), UCLH NHS Foundation Trust, London, NW1 2PG, United Kingdom; University of Zürich Centre for Travel Medicine, WHO Collaborating Centre for Travellers' Health, Institute for Epidemiology, Biostatistics and Prevention, Hirschengraben 84, Zürich, 8001, Switzerland","Rodríguez-Morales, A.J., Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Risaralda, Pereira, Colombia, Grupo de Investigación Biomedicina, Faculty of Medicine, Fundación Universitaria Autónoma de las Américas, Risaralda, Pereira, 660004, Colombia; MacGregor, K., National Travel Health Network and Centre (NaTHNaC), UCLH NHS Foundation Trust, London, NW1 2PG, United Kingdom; Kanagarajah, S., National Travel Health Network and Centre (NaTHNaC), UCLH NHS Foundation Trust, London, NW1 2PG, United Kingdom; Patel, D., National Travel Health Network and Centre (NaTHNaC), UCLH NHS Foundation Trust, London, NW1 2PG, United Kingdom; Schlagenhauf, P., University of Zürich Centre for Travel Medicine, WHO Collaborating Centre for Travellers' Health, Institute for Epidemiology, Biostatistics and Prevention, Hirschengraben 84, Zürich, 8001, Switzerland",[No abstract available],2019-nCoV; Coronaviruses; Epidemic; Travelers,"antivirus agent; interferon beta serine; lopinavir; lopinavir plus ritonavir; oseltamivir; remdesivir; ritonavir; virus vaccine; COVID-19; severe acute respiratory syndrome coronavirus 2; antiviral therapy; Asia; bronchus epithelium; China; Coronavirinae; Coronavirus infection; Editorial; emporiatrics; epidemic; Europe; home care; human; infection risk; international health regulation; interpersonal communication; Middle East respiratory syndrome coronavirus; monotherapy; novel coronavirus 2019; priority journal; public health; risk assessment; SARS coronavirus; severe acute respiratory syndrome; South and Central America; travel; United Kingdom; United States; virus strain; virus transmission; World Health Organization; Betacoronavirus; Coronavirus infection; epidemic; global health; infection control; pathogenicity; practice guideline; virus pneumonia; Betacoronavirus; Communication; Coronavirus Infections; Disease Outbreaks; Europe; Global Health; Guidelines as Topic; Humans; Infection Control; Latin America; Pneumonia, Viral; Travel; Travel Medicine; United Kingdom; United States","World Health Organization, Statement on the second meeting of the International Health Regulations, Emergency Committee regarding the outbreak of novel coronavirus (2019-nCoV) (2005), https://www.who.int/news-room/detail/30-01-2020-statement-on-the-second-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-outbreak-of-novel-coronavirus-(2019-ncov; World Health Organization, Novel coronavirus (2019-nCoV) - situation report - 10 - 30 January 2020 (2020), https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200130-sitrep-10-ncov.pdf?sfvrsn=d0b2e480_2; 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Stoye, M., China coronavirus: how many papers have been published? (2020) Nature","Rodríguez-Morales, A.J.; Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Risaralda, Colombia; email: arodriguezm@utp.edu.co",,Elsevier USA,14778939,,TMIDA,32044389,English,Travel Med. Infect. Dis.,Editorial,Final,Open Access,Scopus,2-s2.0-85079170254,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Chiodini J.,6506465404;,"Maps, masks and media – Traveller and practitioner resources for 2019 novel coronavirus (2019-nCoV) acute respiratory virus",2020,Travel Medicine and Infectious Disease,33,,101574,,,,,10.1016/j.tmaid.2020.101574,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079163795&doi=10.1016%2fj.tmaid.2020.101574&partnerID=40&md5=111ecd1be1ed28c43dc0ec85d21941f0,"Amersham Vale Practice, London, United Kingdom","Chiodini, J., Amersham Vale Practice, London, United Kingdom",[No abstract available],,"acute respiratory tract disease; Coronavirinae; hand washing; health care personnel; human; international health regulation; Note; novel coronavirus 2019; primary medical care; priority journal; public health service; quarantine; respiratory virus; secondary health care; travel; World Health Organization; access to information; consumer health information; Coronavirus infection; emporiatrics; mask; patient education; United States; virus pneumonia; World Health Organization; COVID-19; Access to Information; Centers for Disease Control and Prevention, U.S.; Consumer Health Information; Coronavirus Infections; Humans; Masks; Patient Education as Topic; Pneumonia, Viral; Travel; Travel Medicine; United States; World Health Organization",,,,Elsevier USA,14778939,,TMIDA,32044387,English,Travel Med. Infect. Dis.,Note,Final,Open Access,Scopus,2-s2.0-85079163795,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Kelvin D.J., Rubino S.",7006326577;52664248000;,Fear of the novel coronavirus,2020,Journal of Infection in Developing Countries,14,1,,1,2,,,10.3855/jidc.12496,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079146891&doi=10.3855%2fjidc.12496&partnerID=40&md5=ff39bde388c1d4befeb14dbba2dee3a7,"International Institute of Infection and Immunity, Shantou University Medical College, Shantou, Guangdong, China; Canadian Centre for Vaccinology, IWK Health Centre, Halifax, NS, Canada; Dipartimento di Scienze Biomediche, Universita’ degli Studi di Sassari, Sassari, Italy","Kelvin, D.J., International Institute of Infection and Immunity, Shantou University Medical College, Shantou, Guangdong, China, Canadian Centre for Vaccinology, IWK Health Centre, Halifax, NS, Canada; Rubino, S., Dipartimento di Scienze Biomediche, Universita’ degli Studi di Sassari, Sassari, Italy",[No abstract available],2019-nCoV; China; Outbreak,vaccine; community health nursing; Coronaviridae; disease transmission; Editorial; emergency ward; health care utilization; health program; human; International Society for Infectious Diseases; nonhuman; novel coronavirus 2019; polymerase chain reaction; sequence homology; severe acute respiratory syndrome; social phobia; travel related disease; violence; zoonosis; China; Coronavirinae; Coronavirus infection; fear; pneumonia; China; Coronavirus; Coronavirus Infections; Fear; Humans; Pneumonia,"Zhong, N.S., Zheng, B.J., Li, Y.M., Poon, Xie, Z.H., Chan, K.H., Li, P.H., Peiris, G.Y., Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People’s Republic of China, in February, 2003 (2003) Lancet, 362, pp. 1353-1358; Al-Ahdal, M.N., Al-Qahtani, A.A., Rubino, S., Coronavirus respiratory illness in Saudi Arabia (2012) J Infect Dev Ctries, 6, pp. 692-694; Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., Zhao, X., Tan, W., A novel Coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, , Epub ahead of print; (2020) Laboratory Testing for 2019 Novel Coronavirus (2019-nCoV) in Suspected Human Cases, , https://www.who.int/healthtopics/coronavirus/laboratory-diagnostics-for-novelcoronavirus, Available: Accessed: 25 January 2020; ProMED-Mail, , http://www.promedmail.org, Available: Accessed: 30 January 2020; (2020) Statement on the Second Meeting of the International Health Regulations (2005) Emergency Committee Regarding the Outbreak of Novel Coronavirus (2019-nCoV), , https://www.who.int/news-room/detail/30-01-2020-statementon-the-second-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-outbreak-of-novel-coronavirus-(2019-ncov, Available: Accessed: 1st February, 2020; Statement on the Meeting of the International Health Regulations (2005) Emergency Committee Regarding the Outbreak of Novel Coronavirus (2019-nCoV), , https://www.who.int/news-room/detail/23-01-2020-statement-on-the-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-outbreak-of-novel-coronavirus-(2019-ncov, 2020 Available: Accessed: 25 January 2020","Kelvin, D.J.; Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie UniversityCanada; email: dkelvin@jidc.org",,Journal of Infection in Developing Countries,20366590,,,32088678,English,J. Infect. Dev. Ctries.,Editorial,Final,Open Access,Scopus,2-s2.0-85079146891,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhao S., Zhuang Z., Ran J., Lin J., Yang G., Yang L., He D.",57194229769;57215413912;57201898116;57211366428;57214807238;57105980700;7403045834;,The association between domestic train transportation and novel coronavirus (2019-nCoV) outbreak in China from 2019 to 2020: A data-driven correlational report,2020,Travel Medicine and Infectious Disease,33,,101568,,,,3,10.1016/j.tmaid.2020.101568,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079138964&doi=10.1016%2fj.tmaid.2020.101568&partnerID=40&md5=cf552c6f6eabcdb0caaf2abd3bc18312,"JC School of Public Health and Primary Care, Chinese University of Hong Kong, Hong Kong; Shenzhen Research Institute of Chinese University of Hong Kong, Shenzhen, China; Department of Applied Mathematics, Hong Kong Polytechnic University, Hong Kong; School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong; Department of Orthopaedics and Traumatology, Chinese University of Hong Kong, Hong Kong; SH Ho Scoliosis Research Lab, Joint Scoliosis Research Center of Chinese University of Hong Kong and Nanjing University, Hong Kong; School of Nursing, Hong Kong Polytechnic University, Hong Kong","Zhao, S., JC School of Public Health and Primary Care, Chinese University of Hong Kong, Hong Kong, Shenzhen Research Institute of Chinese University of Hong Kong, Shenzhen, China; Zhuang, Z., Department of Applied Mathematics, Hong Kong Polytechnic University, Hong Kong; Ran, J., School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong; Lin, J., JC School of Public Health and Primary Care, Chinese University of Hong Kong, Hong Kong; Yang, G., Department of Orthopaedics and Traumatology, Chinese University of Hong Kong, Hong Kong, SH Ho Scoliosis Research Lab, Joint Scoliosis Research Center of Chinese University of Hong Kong and Nanjing University, Hong Kong; Yang, L., School of Nursing, Hong Kong Polytechnic University, Hong Kong; He, D., Department of Applied Mathematics, Hong Kong Polytechnic University, Hong Kong",[No abstract available],,"2019 novel coronavirus; China; Coronavirus infection; epidemic; human; Letter; priority journal; railway; traffic and transport; travel; virus transmission; Betacoronavirus; Coronavirus infection; data analysis; pathogenicity; statistical model; virus pneumonia; COVID-19; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; China; Coronavirus Infections; Data Analysis; Disease Outbreaks; Humans; Models, Statistical; Pneumonia, Viral; Transportation; Travel","Pneumonia of unknown cause – China, Emergencies preparedness, response, Disease outbreak news, World Health Organization (WHO) https://www.who.int/csr/don/05-january-2020-pneumonia-of-unkown-cause-china/en/; Imai, N., Dorigatti, I., Cori, A., Riley, S., Ferguson, N.M., Estimating the potential total number of novel Coronavirus (2019-nCoV) cases in Wuhan City, China (2020), Preprint published by the Imperial College London; Bogoch, Watts, A., Thomas-Bachli, A., Huber, C., Kraemer, M.U., Khan, K., Pneumonia of unknown etiology in Wuhan, China: Potential for international spread via commercial air travel (2020) J Trav Med, p. taaa008","Zhao, S.; JC School of Public Health and Primary Care, Chinese University of Hong KongHong Kong; email: shi.zhao@link.cuhk.edu.hk",,Elsevier USA,14778939,,TMIDA,32006656,English,Travel Med. Infect. Dis.,Letter,Final,Open Access,Scopus,2-s2.0-85079138964,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Bonilla-Aldana D.K., Quintero-Rada K., Montoya-Posada J.P., Ramírez-Ocampo S., Paniz-Mondolfi A., Rabaan A.A., Sah R., Rodríguez-Morales A.J.",57208153819;57215002466;57215010680;57200141085;8331702100;56049830800;57195544674;8886801000;,"SARS-CoV, MERS-CoV and now the 2019-novel CoV: Have we investigated enough about coronaviruses? – A bibliometric analysis",2020,Travel Medicine and Infectious Disease,33,,101566,,,,3,10.1016/j.tmaid.2020.101566,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079121719&doi=10.1016%2fj.tmaid.2020.101566&partnerID=40&md5=2ca16f718bf74b337d230c02f3333d4d,"Semillero de Investigación en Zoonosis, Grupo de Investigación BIOECOS, Fundación Universitaria Autónoma de las Américas, Pereira, Risaralda, Colombia; Public Health and Infection Research and Incubator Group, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia; Laboratory of Medical Microbiology, Department of Pathology, Molecular and Cell-based Medicine, The Mount Sinai Hospital-Icahn School of Medicine at Mount Sinai, New York, United States; Laboratorio de Señalización Celular y Bioquímica de Parásitos, Instituto de Estudios Avanzados (IDEA), Caracas, Caracas, Venezuela; Academia Nacional de Medicina, Caracas, Venezuela; Instituto de Investigaciones Biomedicas IDB / Incubadora Venezolana de la Ciencia, Cabudare, Edo. Lara, Venezuela; Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia; Department of Microbiology, Tribhuvan University Teaching Hospital, Institute of Medicine, Kathmandu, Nepal; Grupo de Investigación Biomedicina, Faculty of Medicine, Fundación Universitaria Autónoma de las Américas, Risaralda, Pereira, 660004, Colombia","Bonilla-Aldana, D.K., Semillero de Investigación en Zoonosis, Grupo de Investigación BIOECOS, Fundación Universitaria Autónoma de las Américas, Pereira, Risaralda, Colombia, Public Health and Infection Research and Incubator Group, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia; Quintero-Rada, K., Semillero de Investigación en Zoonosis, Grupo de Investigación BIOECOS, Fundación Universitaria Autónoma de las Américas, Pereira, Risaralda, Colombia; Montoya-Posada, J.P., Semillero de Investigación en Zoonosis, Grupo de Investigación BIOECOS, Fundación Universitaria Autónoma de las Américas, Pereira, Risaralda, Colombia; Ramírez-Ocampo, S., Public Health and Infection Research and Incubator Group, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia; Paniz-Mondolfi, A., Laboratory of Medical Microbiology, Department of Pathology, Molecular and Cell-based Medicine, The Mount Sinai Hospital-Icahn School of Medicine at Mount Sinai, New York, United States, Laboratorio de Señalización Celular y Bioquímica de Parásitos, Instituto de Estudios Avanzados (IDEA), Caracas, Caracas, Venezuela, Academia Nacional de Medicina, Caracas, Venezuela, Instituto de Investigaciones Biomedicas IDB / Incubadora Venezolana de la Ciencia, Cabudare, Edo. Lara, Venezuela; Rabaan, A.A., Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia; Sah, R., Department of Microbiology, Tribhuvan University Teaching Hospital, Institute of Medicine, Kathmandu, Nepal; Rodríguez-Morales, A.J., Public Health and Infection Research and Incubator Group, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia, Grupo de Investigación Biomedicina, Faculty of Medicine, Fundación Universitaria Autónoma de las Américas, Risaralda, Pereira, 660004, Colombia",[No abstract available],,2019 novel coronavirus; bibliographic database; bibliometrics; Coronavirinae; epidemic; Letter; medical research; Middle East respiratory syndrome coronavirus; nonhuman; priority journal; public health; SARS coronavirus; World Health Organization,"Momattin, H., Al-Ali, A.Y., Al-Tawfiq, J.A., A systematic review of therapeutic agents for the treatment of the Middle East respiratory syndrome coronavirus (MERS-CoV) (2019) Trav Med Infect Dis, 30, pp. 9-18; Cui, J., Li, F., Shi, Z.L., Origin and evolution of pathogenic coronaviruses (2019) Nat Rev Microbiol, 17, pp. 181-192; World Health Organization, List of Blueprint priority diseases (2018), https://www.who.int/activities/prioritizing-diseases-for-research-and-development-in-emergency-contexts, URL:; Leung, G.M., Chung, P.H., Tsang, T., Lim, W., Chan, S.K., Chau, P., SARS-CoV antibody prevalence in all Hong Kong patient contacts (2004) Emerg Infect Dis, 10, pp. 1653-1656; Khan, A., Farooqui, A., Guan, Y., Kelvin, D.J., Lessons to learn from MERS-CoV outbreak in South Korea (2015) J Infect Dev Ctries, 9, pp. 543-546; Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., A novel coronavirus from patients with pneumonia in China (2019) N Engl J Med, , 2020; Rodriguez-Morales, A.J., Ramirez-Jaramillo, V., Patino-Barbosa, A.M., Bedoya-Arias, H.A., Henao-SanMartin, V., Murillo-Garcia, D.R., Severe fever with thrombocytopenia syndrome - a bibliometric analysis of an emerging priority disease (2018) Trav Med Infect Dis, 23, pp. 97-98","Rodríguez-Morales, A.J.; Public Health and Infection Research and Incubator Group, Faculty of Health Sciences, Universidad Tecnológica de PereiraColombia; email: arodriguezm@utp.edu.co",,Elsevier USA,14778939,,TMIDA,32007621,English,Travel Med. Infect. Dis.,Letter,Final,Open Access,Scopus,2-s2.0-85079121719,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Mowbray H.,57214773979;,"In Beijing, coronavirus 2019-nCoV has created a siege mentality",2020,The BMJ,368,, m516,,,,1,10.1136/bmj.m516,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079081422&doi=10.1136%2fbmj.m516&partnerID=40&md5=93678e25a2c7ce444043c1fbfb4d5580,"Beijing, China","Mowbray, H., Beijing, China",[No abstract available],,2019 novel coronavirus; attitude to health; China; Coronavirinae; epidemic; health care system; health hazard; human; infection control; misinformation; Note; patient isolation; priority journal; public health,,"Mowbray, H.China; email: hcmowbray@gmail.com",,BMJ Publishing Group,9598146,,BMJOA,32033967,English,BMJ,Note,Final,Open Access,Scopus,2-s2.0-85079081422,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Lee P.-I., Hsueh P.-R.",7406120769;7103390478;,Emerging threats from zoonotic coronaviruses-from SARS and MERS to 2019-nCoV,2020,"Journal of Microbiology, Immunology and Infection",,,,,,,5,10.1016/j.jmii.2020.02.001,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078958617&doi=10.1016%2fj.jmii.2020.02.001&partnerID=40&md5=3b69a10c9500861fcbe753f9bafc5f59,"Department of Pediatrics, National Taiwan University Children's Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan","Lee, P.-I., Department of Pediatrics, National Taiwan University Children's Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Hsueh, P.-R., Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan, Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan",[No abstract available],,,"Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, , [Epub ahead of print]; Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med; Lee, K.H., Yoo, S.G., Cho, Y., Kwon, D.E., La, Y., Han, S.H., Characteristics of community-acquired respiratory viruses infections except seasonal influenza in transplant recipients and non-transplant critically ill patients (2019) J Microbiol Immunol Infect, , [Epub ahead of print]; Alfaraj, S.H., Al-Tawfiq, J.A., Memish, Z.A., Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection during pregnancy: report of two cases & review of the literature (2019) J Microbiol Immunol Infect, 52, pp. 501-503; Munster, V.J., Koopmans, M., van Doremalen, N., van Riel, D., de Wit, E., A novel coronavirus emerging in China — key questions for impact assessment (2020) N Engl J Med, , [Epub ahead of print]; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, , [Epub ahead of print]; Perlman, S., Another decade, another coronavirus (2020) N Engl J Med, , [Epub ahead of print]; Enserink, M., SARS: chronology of the epidemic (2013) Science, 339, pp. 1266-1271; Raj, V.S., Mou, H., Smits, S.L., Dekkers, D.H., Müller, M.A., Dijkman, R., Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC (2013) Nature, 495 (7440), pp. 251-254; Zhong, N., Zeng, G., What we have learnt from SARS epidemics in China (2006) Br Med J, 19 (333), pp. 389-391; Lu, H.Z., Drug treatment options for the 2019-new coronavirus (2019- nCoV) (2020) BioSci Trends, , Advance Publication; Holshue, M.L., DeBolt, C., Lindquist, S., Lofy, K.H., Wiesman, J., Bruce, H., First case of 2019 novel coronavirus in the United States (2020) N Engl J Med","Lee, P.-I.; Department of Pediatrics, National Taiwan University Children's Hospital, No.8, Chung Shan S. Rd., Taiwan; email: pinging@ntu.edu.tw",,Elsevier Ltd,16841182,,JMIIF,,English,J. Microbiol. Immunol. Infect.,Article,Article in Press,Open Access,Scopus,2-s2.0-85078958617,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Moberly T.,55661023200;,"Following the evidence, from coronavirus to terrorism response",2020,The BMJ,368,, m344,,,,,10.1136/bmj.m344,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078930202&doi=10.1136%2fbmj.m344&partnerID=40&md5=3c7a36a1c0da4c8adb1441f593764d68,,"Moberly, T.",[No abstract available],,drinking water; 2019 novel coronavirus; cancer screening; China; Coronavirinae; Coronavirus infection; fermented soybean; food intake; human; mortality; Note; priority journal; quarantine; sanitation; social welfare; soy food; survival; terrorism; travel; uterine cervix cancer,,"Moberly, T.email: tmoberly@bmj.com",,BMJ Publishing Group,9598146,,BMJOA,,English,BMJ,Note,Final,Open Access,Scopus,2-s2.0-85078930202,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Biscayart C., Angeleri P., Lloveras S., Chaves T.D.S.S., Schlagenhauf P., Rodríguez-Morales A.J.",6504677593;57210022633;6507733544;52963231300;7003453274;8886801000;,"The next big threat to global health? 2019 novel coronavirus (2019-nCoV): What advice can we give to travellers? – Interim recommendations January 2020, from the Latin-American society for Travel Medicine (SLAMVI)",2020,Travel Medicine and Infectious Disease,33,,101567,,,,9,10.1016/j.tmaid.2020.101567,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078861706&doi=10.1016%2fj.tmaid.2020.101567&partnerID=40&md5=4c6b3aaae0f7ccbe3ad8acf074fc93d7,"Fundación Centro de Estudios Infectológicos (FUNCEI), Buenos Aires, Argentina; Panel of Scientific Publications and Teaching, Latin American Society for Travel Medicine (SLAMVI), Buenos Aires, Argentina; Hospital General de Agudos P. Piñero, Buenos Aires, Argentina; Panel of Sports and Travel, Latin American Society for Travel Medicine (SLAMVI), Buenos Aires, Argentina; Hospital de Enfermedades Infecciosas Francisco J. Muñiz, Buenos Aires, Argentina; Evandro Chagas Institute, Health of Ministry of Brazil, Rodovia BR 316 Km 07, S/N, CEP 67030-000, Ananindeua, Pará, Brazil; Faculdade de Medicina da Universidade Federal Do ParáPará, Brazil; Centro Universitário Do Pará/MedicinaPará, Brazil; Panel of Vaccines in Travelers, Latin American Society for Travel Medicine (SLAMVI)Pará, Brazil; University of Zürich Centre for Travel Medicine, WHO Collaborating Centre for Travellers' Health, Institute for Epidemiology, Biostatistics and Prevention, Hirschengraben 84, Zürich, 8001, Switzerland; Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia; Grupo de Investigación Biomedicina, Faculty of Medicine, Fundación Universitaria Autónoma de Las Américas, Pereira, Risaralda 660004, Colombia","Biscayart, C., Fundación Centro de Estudios Infectológicos (FUNCEI), Buenos Aires, Argentina, Panel of Scientific Publications and Teaching, Latin American Society for Travel Medicine (SLAMVI), Buenos Aires, Argentina; Angeleri, P., Hospital General de Agudos P. Piñero, Buenos Aires, Argentina; Lloveras, S., Panel of Scientific Publications and Teaching, Latin American Society for Travel Medicine (SLAMVI), Buenos Aires, Argentina, Panel of Sports and Travel, Latin American Society for Travel Medicine (SLAMVI), Buenos Aires, Argentina, Hospital de Enfermedades Infecciosas Francisco J. Muñiz, Buenos Aires, Argentina; Chaves, T.D.S.S., Evandro Chagas Institute, Health of Ministry of Brazil, Rodovia BR 316 Km 07, S/N, CEP 67030-000, Ananindeua, Pará, Brazil, Faculdade de Medicina da Universidade Federal Do ParáPará, Brazil, Centro Universitário Do Pará/MedicinaPará, Brazil, Panel of Vaccines in Travelers, Latin American Society for Travel Medicine (SLAMVI)Pará, Brazil; Schlagenhauf, P., University of Zürich Centre for Travel Medicine, WHO Collaborating Centre for Travellers' Health, Institute for Epidemiology, Biostatistics and Prevention, Hirschengraben 84, Zürich, 8001, Switzerland; Rodríguez-Morales, A.J., Panel of Scientific Publications and Teaching, Latin American Society for Travel Medicine (SLAMVI), Buenos Aires, Argentina, Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia, Grupo de Investigación Biomedicina, Faculty of Medicine, Fundación Universitaria Autónoma de Las Américas, Pereira, Risaralda 660004, Colombia",[No abstract available],2019 novel Coronavirus; 2019-nCoV; Coronaviruses; Latin America; Travelers,"Coronavirinae; Editorial; emporiatrics; global health; human; incubation time; life threat; priority journal; travel; Betacoronavirus; Coronavirus infection; emporiatrics; epidemic; medical society; Melia azedarach; pathogenicity; practice guideline; South and Central America; virus pneumonia; COVID-19; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; Coronavirus Infections; Disease Outbreaks; Guidelines as Topic; Humans; Infectious Disease Incubation Period; Latin America; Melia azedarach; Pneumonia, Viral; Societies, Medical; Travel; Travel Medicine","Lu, H., Stratton, C.W., Tang, Y.W., Outbreak of pneumonia of unknown etiology in wuhan China: the mystery and the miracle (2020) J Med Virol; Zhou, P., Yang, X.-L., Wang, X.-G., Hu, B., Zhang, L., Zhang, W., Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin (2020) bioRxiv, , In press; Wuhan airport. Wuhan airport https://www.wuhan-airport.com/, 2020; AICM en Cifras (2018), https://www.aicm.com.mx/acercadelaicm/archivos/files/Estadisticas/Estadisticas2018.pdf, Diciembre 2018; GRU airport https://www.gru.com.br/pt/RelatorioOperacional/2018-12.pdf, 2018; Aeronautica Civil de Colombia, Boletines operacionales (2020), http://www.aerocivil.gov.co/atencion/estadisticas-de-las-actividades-aeronauticas/boletines-operacionales; Luo, G.G., Gao, S.J., Global health concern stirred by emerging viral infections (2020) J Med Virol; Zhang, N., Wang, L., Deng, X., Liang, R., Su, M., He, C., Recent advances in the detection of respiratory virus infection in humans (2020) J Med Virol; Yang, D., Leibowitz, J.L., The structure and functions of coronavirus genomic 3' and 5' ends (2015) Virus Res, 206, pp. 120-133; Chen, Y., Liu, Q., Guo, D., Emerging coronaviruses: genome structure, replication, and pathogenesis (2020) J Med Virol; Yin, Y., Wunderink, R.G., MERS, SARS and other coronaviruses as causes of pneumonia (2018) Respirology, 23, pp. 130-137; Al-Tawfiq, J.A., Zumla, A., Memish, Z.A., Travel implications of emerging coronaviruses: SARS and MERS-CoV (2014) Trav Med Infect Dis, 12, pp. 422-428; Wilder-Smith, A., The severe acute respiratory syndrome: impact on travel and tourism (2006) Trav Med Infect Dis, 4, pp. 53-60; Al-Tawfiq, J.A., Gautret, P., Asymptomatic Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection: extent and implications for infection control: a systematic review (2019) Trav Med Infect Dis, 27, pp. 27-32; Baharoon, S., Memish, Z.A., MERS-CoV as an emerging respiratory illness: a review of prevention methods (2019) Trav Med Infect Dis, p. 101520; Cheng, V.C.C., Wong, S.C., To, K.K.W., Ho, P.L., Yuen, K.Y., Preparedness and proactive infection control measures against the emerging Wuhan coronavirus pneumonia in China (2020) J Hosp Infect; Callaway, E., Cyranoski, D., Why snakes probably aren't spreading the new China virus (2020) Nature; Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med; Chan, J.F.-W., Yuan, S., Kok, K.-H., To, K.K.-W., Chu, H., Yang, J., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet; World Health Organization, Novel coronavirus (2019-nCoV) - situation report - 4 - 24 january 2020 https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200124-sitrep-4-2019-ncov.pdf?sfvrsn=9272d086_2, 2020; World Health Organization, Novel coronavirus (2019-nCoV) - situation report - 7 - 27 january 2020 https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200127-sitrep-7-2019--ncov.pdf?sfvrsn=98ef79f5_2020, 2020; World Health Organization, Statement on the meeting of the international health Regulations (2005) emergency committee regarding the outbreak of novel coronavirus (2019-nCoV) https://www.who.int/news-room/detail/23-01-2020-statement-on-the-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-outbreak-of-novel-coronavirus-(2019-ncov, 2020; Gallego, V., Berberian, G., Lloveras, S., Verbanaz, S., Chaves, T.S., Orduna, T., The 2014 FIFA World Cup: communicable disease risks and advice for visitors to Brazil--a review from the Latin American Society for Travel Medicine (SLAMVI) (2014) Trav Med Infect Dis, 12, pp. 208-218; Gallego, V., Berberian, G., Siu, H., Verbanaz, S., Rodriguez-Morales, A.J., Gautret, P., The 2019 Pan American games: communicable disease risks and travel medicine advice for visitors to Peru - recommendations from the Latin American Society for Travel Medicine (SLAMVI) (2019) Trav Med Infect Dis, 30, pp. 19-24; Ishikawa, H., Shimogawara, R., Risk assessment of dengue autochthonous infections in Tokyo during summer, especially in the period of the 2020 olympic games (2019) Jpn J Infect Dis, 72, pp. 399-406","Rodríguez-Morales, A.J.; Panel of Scientific Publications and Teaching, Latin American Society for Travel Medicine (SLAMVI)Argentina; email: arodriguezm@utp.edu.co",,Elsevier USA,14778939,,TMIDA,32006657,English,Travel Med. Infect. Dis.,Editorial,Final,Open Access,Scopus,2-s2.0-85078861706,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Rodriguez-Morales A.J., Bonilla-Aldana D.K., Balbin-Ramon G.J., Rabaan A.A., Sah R., Paniz-Mondolfi A., Pagliano P., Esposito S.",8886801000;57208153819;57214601024;56049830800;57195544674;8331702100;6602072168;7202860651;,History is repeating itself: Probable zoonotic spillover as the cause of the 2019 novel coronavirus epidemic,2020,Infezioni in Medicina,28,1,,3,5,,7,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078850043&partnerID=40&md5=c7b16da3e136205e71bf3f89b11c9d87,"Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Colombia; Grupo de Investigación Biomedicina, Faculty of Medicine, Fundación Universitaria Autónoma de las Américas, Pereira, Risaralda, Colombia; Master in Clinical Epidemiology and Biostatistics, Universidad Cientifica del Sur, Lima, Peru; Incubator in Zoonosis (SIZOO), Biodiversity and Ecosystem Conservation Research Group (BIOECOS), Fundación Universitaria Autónoma de las Américas, Sede Pereira, Pereira, Risaralda, Colombia; Hospital de Emergencias José Casimo Ulloa, Lima, Peru; Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia; Department of Microbiology, Tribhuvan University Teaching Hospital, Institute of Medicine, Kathmandu, Nepal; Laboratory of Medical Microbiology, Department of Pathology, Molecular and Cell-based Medicine, The Mount Sinai Hospital-Icahn School of Medicine at Mount SinaiNY, United States; Instituto de Investigaciones Biomédicas IDB/Incubadora Venezolana de la Ciencia, Cabudare, Lara, Venezuela; Academia Nacional de Medicina, Caracas, Venezuela; Department of Infectious Diseases, University of Salerno, Salerno, Italy","Rodriguez-Morales, A.J., Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Colombia, Grupo de Investigación Biomedicina, Faculty of Medicine, Fundación Universitaria Autónoma de las Américas, Pereira, Risaralda, Colombia, Master in Clinical Epidemiology and Biostatistics, Universidad Cientifica del Sur, Lima, Peru; Bonilla-Aldana, D.K., Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Colombia, Incubator in Zoonosis (SIZOO), Biodiversity and Ecosystem Conservation Research Group (BIOECOS), Fundación Universitaria Autónoma de las Américas, Sede Pereira, Pereira, Risaralda, Colombia; Balbin-Ramon, G.J., Master in Clinical Epidemiology and Biostatistics, Universidad Cientifica del Sur, Lima, Peru, Hospital de Emergencias José Casimo Ulloa, Lima, Peru; Rabaan, A.A., Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia; Sah, R., Department of Microbiology, Tribhuvan University Teaching Hospital, Institute of Medicine, Kathmandu, Nepal; Paniz-Mondolfi, A., Laboratory of Medical Microbiology, Department of Pathology, Molecular and Cell-based Medicine, The Mount Sinai Hospital-Icahn School of Medicine at Mount SinaiNY, United States, Instituto de Investigaciones Biomédicas IDB/Incubadora Venezolana de la Ciencia, Cabudare, Lara, Venezuela, Academia Nacional de Medicina, Caracas, Venezuela; Pagliano, P., Department of Infectious Diseases, University of Salerno, Salerno, Italy; Esposito, S., Department of Infectious Diseases, University of Salerno, Salerno, Italy",[No abstract available],,"anthrax; Coronavirinae; Coronavirus infection; disease transmission; Editorial; epidemic; Filovirus; food poisoning; foodborne pathogen; histoplasmosis; human; Lyssavirus; Middle East respiratory syndrome coronavirus; nonhuman; Paramyxoviridae; public health; rabies; Reoviridae; sea food; seroprevalence; severe acute respiratory syndrome; virus transmission; zoonosis; animal; bat; China; Coronavirinae; Coronavirus infection; epidemic; mammal; pathogenicity; virology; virus pneumonia; zoonosis; COVID-19; Animals; China; Chiroptera; Coronavirus; Coronavirus Infections; Disease Outbreaks; Epidemics; Humans; Mammals; Pneumonia, Viral; Zoonoses","Plowright, R.K., Parrish, C.R., McCallum, H., Hudson, P.J., Ko, A.I., Graham, A.L., Pathways to zoonotic spillover (2017) Nat Rev Microbiol, 15 (8), pp. 502-510; Iturriza-Gomara, M., O’Brien, S.J., Foodborne viral infections (2016) Curr Opin Infect Dis, 29 (5), pp. 495-501; Al-Tawfiq, J.A., Zumla, A., Memish, Z.A., Travel implications of emerging coronaviruses: SARS and MERS-CoV (2014) Travel Med Infect Dis, 12 (5), pp. 422-428; Wilder-Smith, A., The severe acute respiratory syndrome: Impact on travel and tourism (2006) Travel Med Infect Dis, 4 (2), pp. 53-60; Zhou, P., Yang, X.-L., Wang, X.-G., Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin (2020) Biorxiv., , 2020.01.22.914952; Chen, Y., Liu, Q., Guo, D., Coronaviruses: Genome structure, replication, and pathogenesis (2020) J Med Virol; Cui, J., Li, F., Shi, Z.L., Origin and evolution of pathogenic coronaviruses (2019) Nat Rev Microbiol, 17 (3), pp. 181-192; Chan, J.-W., Yuan, S., Kok, K.-H., To, K.-W., Chu, H., Yang, J., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: A study of a family cluster (2020) The Lancet; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) The Lancet; Zhu, N., Zhang, D., Wang, W., A Novel Coronavirus from Patients with Pneumonia in China (2019) N Engl J Med, 2020; Wang, L.F., Anderson, D.E., Viruses in bats and potential spillover to animals and humans (2019) Curr Opin Virol, 34, pp. 79-89; Calderon, A., Guzman, C., Mattar, S., Rodriguez, V., Acosta, A., Martinez, C., Frugivorous bats in the Colombian Caribbean region are reservoirs of the rabies virus (2019) Ann Clin Microbiol Antimicrob, 18 (1); Calderon, A., Guzman, C., Mattar, S., Rodriguez, V., Martinez, C., Violet, L., Dengue Virus in Bats from Cordoba and Sucre, Colombia (2019) Vector Borne Zoonotic Dis, 19 (10), pp. 747-751","Rodriguez-Morales, A.J.; Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnológica de PereiraColombia; email: arodriguezm@utp.edu.co",,EDIMES Edizioni Medico Scientifiche,11249390,,INMEF,32009128,English,Infez. Med.,Editorial,Final,,Scopus,2-s2.0-85078850043,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Flear M., De Ruijter A., McKee M.",35487179500;57191165083;57209986236;,Coronavirus shows how UK must act quickly before being shut out of Europe's health protection systems,2020,The BMJ,368,, m400,,,,1,10.1136/bmj.m400,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078839120&doi=10.1136%2fbmj.m400&partnerID=40&md5=370cd643848ba7de91746257b30264c7,"Queen's University Belfast, Belfast, United Kingdom; Amsterdam Law School, Amsterdam, Netherlands; London School of Hygiene and Tropical Medicine, London, United Kingdom","Flear, M., Queen's University Belfast, Belfast, United Kingdom; De Ruijter, A., Amsterdam Law School, Amsterdam, Netherlands; McKee, M., London School of Hygiene and Tropical Medicine, London, United Kingdom",[No abstract available],,2019 novel coronavirus; Article; Coronavirinae; Coronavirus infection; disease control; European Union; government regulation; health care need; health hazard; health promotion; human; international cooperation; participatory management; preventive health service; priority journal; Switzerland; United Kingdom; World Health Organization,"Mahase, E., China coronavirus: WHO declares international emergency as death toll exceeds 200 (2020) BMJ, 368, p. m408; (2005) Strengthening Health Security by Implementing the International Health Regulations, , https://www.who.int/ihr/en, World Health Organization; Regulation (EC) 851/2004 of the European Parliament and of the Council of 21 April 2004 establishing a European Centre for Disease Prevention and Control (2004) Official Journal of the European Union, 47, p. L142. , European Union; Miller, J., Swiss seek access to EU early-warning system as coronavirus spreads (2020) Swissinfo., , https://www.swissinfo.ch/eng/reuters/swiss-seek-access-to-eu-early-warningsystem-as-coronavirus-spreads/45523616, Jan; De Ruijter, A., EU Health Law & Policy: The Expansion of EU Power in Public Health and Health Care, , Oxford University Press, 201910.1093/oso/9780198788096.001.0001; Flear, M., (2015) Governing Public Health: EU Law, Regulation and Biopolitics., , Bloomsbury Publishing; (2020) Early Warning and Response System of the European Union (EWRS), , https://www.ecdc.europa.eu/en/publicationsdata/early-warning-and-response-system-european-union-ewrs, European Centre for Disease Prevention and Control; European Union. Decision 1082/2013/EU on serious cross-border threats to health and repealing Decision 2119/98/EC. Official Journal of the European Union 2013;L293/1; (2020) Novel Coronavirus in China, , https://www.ecdc.europa.eu/en/novel-coronavirus-china, European Centre for Disease Prevention and Control, accessed 29th January 2020; De Ruijter, A., (2017) Mixing EU Security and Public Health Expertise in the Health Threats Decision, , de Ruijter A, Weimer M, eds, Regulating risks in the European Union. Hart Publishing; European Union. Agreement on the withdrawal of the United Kingdom of Great Britain and Northern Ireland from the European Union and the European Atomic Energy Community [2019] (Withdrawal Agreement). Official Journal of the European Union 2019;C384 I/1; Elborn, S., Flear, M., Downey, D., Implications of ""no deal"" Brexit for orphan and paediatric medicines (2019) BMJ Opinion, , https://blogs.bmj.com/bmj/2019/07/19/implications-of-nodeal-brexit-for-orphan-and-paediatric-medicines; Bastos, F.B., De Ruijter, A., (2019) Break or Bend in Case of Emergency? Rule of Law and State of Emergency in European Public Health Administration., , Nov, Amsterdam Law School research paper 2019-38; (2020), https://www.ecdc.europa.eu/en/about-us/who-we-work/ecdc-partnerships, European Centre for Disease Prevention and Control, ECDC partnerships; Armstrong, K., Brexternalities (2020) Article 50 and the UK's Grossly Irresponsible Attempt to Export Its Own Problems, , https://www.prospectmagazine.co.uk/world/brexternalities-article-50-and-the-uks-grossly-irresponsible-attempt-to-export-its-ownproblems, Prospect., Jan; Fahy, N., Hervey, T., Greer, S., How will Brexit affect health services in the UK? An updated evaluation (2019) Lancet, 393, pp. 949-958. , 30819519","McKee, M.; London School of Hygiene and Tropical MedicineUnited Kingdom; email: martin.mckee@lshtm.ac.uk",,BMJ Publishing Group,9598146,,BMJOA,32005657,English,BMJ,Article,Final,Open Access,Scopus,2-s2.0-85078839120,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Jiang S., Du L., Shi Z.",56491898300;57214594453;7403733955;,"An emerging coronavirus causing pneumonia outbreak in Wuhan, China: calling for developing therapeutic and prophylactic strategies",2020,Emerging Microbes and Infections,9,1,,275,277,,11,10.1080/22221751.2020.1723441,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078834780&doi=10.1080%2f22221751.2020.1723441&partnerID=40&md5=37600598288e0432a042ff662c9ff5f8,"Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Fudan University, Shanghai, China; Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, United States; CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China","Jiang, S., Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Fudan University, Shanghai, China, Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, United States; Du, L., Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, United States; Shi, Z., CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China",[No abstract available],,"neutralizing antibody; COVID-19; epitope; monoclonal antibody; severe acute respiratory syndrome coronavirus 2; virus antibody; amino terminal sequence; Betacoronavirus; China; Coronavirus infection; epidemic; gene sequence; human; Middle East respiratory syndrome coronavirus; nonhuman; Note; phylogeny; pneumonia; priority journal; real time reverse transcription polymerase chain reaction; reverse transcription loop mediated isothermal amplification; reverse transcription polymerase chain reaction; SARS coronavirus; sea food; virus detection; virus identification; animal; bat; communicable disease; Coronavirus infection; nucleic acid amplification; pathogenicity; virology; virus pneumonia; Animals; Antibodies, Monoclonal; Antibodies, Neutralizing; Antibodies, Viral; Betacoronavirus; China; Chiroptera; Communicable Diseases, Emerging; Coronavirus Infections; Epitopes; Humans; Nucleic Acid Amplification Techniques; Phylogeny; Pneumonia, Viral","Lu, H., Cw, S., Tang, Y.W., Outbreak of pneumonia of unknown etiology in Wuhan China: the mystery and the miracle (2020) J Med Virol, 92; Jf, C., Kh, K., Zhu, Z., Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from patients with acute respiratory disease in Wuhan, Hubei, China (2020) Emerg Microbes Infect, 9, pp. 221-236; Hu, D., Zhu, C., Ai, L., Genomic characterization and infectivity of a novel SARS-like coronavirus in Chinese bats (2018) Emerg Microbes Infect, 7 (154); Zhang, N., Wang, L., Deng, X., Recent advances in the detection of respiratory virus infection in humans (2020) J Med Virol, 92. , https://doi.org/10.1002/jmv.25674; Du, L., He, Y., Zhou, Y., The spike protein of SARS-CoV—a target for vaccine and therapeutic development (2009) Nat Rev Microbiol, 7, pp. 226-236; Liu, S., Xiao, G., Chen, Y., Interaction between heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitors (2004) Lancet, 363, pp. 938-947; Xia, S., Yan, L., Xu, W., A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike (2019) Sci Adv, 5, p. eaav4580; Du, L., Yang, Y., Zhou, Y., MERS-CoV spike protein: a key target for antivirals (2017) Expert Opin Ther Targets, 21, pp. 131-143; Zhou, Y., Yang, Y., Huang, J., Advances in MERS-CoV vaccines and therapeutics based on the receptor-binding domain (2019) Viruses, 11, p. pii: E60; Du, L., Tai, W., Yang, Y., Introduction of neutralizing immunogenicity index to the rational design of MERS coronavirus subunit vaccines (2016) Nat Commun, 7, p. 13473; Wang, L., Shi, W., Joyce, M.G., Evaluation of candidate vaccine approaches for MERS-CoV (2015) Nat Commun, 6, p. 7712; Chen, Y., Lu, S., Jia, H., A novel neutralizing monoclonal antibody targeting the N-terminal domain of the MERS-CoV spike protein (2017) Emerg Microbes Infect, 6, p. e37; Zeng, L.P., Ge, X.-Y., Peng, C., Cross-neutralization of SARS coronavirus-specific antibodies against bat SARS-like coronaviruses (2017) Sci China Life Sci., 60, pp. 1399-1402","Jiang, S.; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Fudan UniversityUnited States; email: shibojiang@fudan.edu.cn",,Taylor and Francis Ltd.,22221751,,,32005086,English,Emerg. Microbes Infect.,Note,Final,Open Access,Scopus,2-s2.0-85078834780,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Kickbusch I., Leung G.",7004219139;7007159841;,Response to the emerging novel coronavirus outbreak,2020,The BMJ,368,, m406,,,,2,10.1136/bmj.m406,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078832422&doi=10.1136%2fbmj.m406&partnerID=40&md5=cbc28bee08eefd7430cc858b4774ef1e,"Global Health Programme, Graduate Institute of International and Development Studies, Geneva, Switzerland; Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, Hong Kong","Kickbusch, I., Global Health Programme, Graduate Institute of International and Development Studies, Geneva, Switzerland; Leung, G., Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, Hong Kong",[No abstract available],,2019 novel coronavirus; China; Coronavirinae; Coronavirus infection; disease surveillance; Editorial; epidemic; human; infection control; international cooperation; pandemic; politics; priority journal; quarantine; racism,"(2019) Global Preparedness Monitoring Board, , https://apps.who.int/gpmb/flagship-report.html, Flagship report; (2019) Novel Coronavirus, , https://www.who.int/emergencies/diseases/novel-coronavirus-2019, World Health Organization; WHO, China Leaders Discuss Next Steps in Battle against Coronavirus Outbreak., , https://www.who.int/news-room/detail/28-01-2020-who-chinaleaders-discuss-next-steps-in-battle-against-coronavirus-outbreak, World Health Organization; Middle East Respiratory Syndrome Is Testing Asia's Ability to Address Emerging Diseases., , https://www.adb.org/news/features/middle-east-respiratorysyndrome-testing-asia-s-ability-address-emerging-diseases, Asian Development Bank; (2005) Strengthening Health Security by Implementing the International Health Regulations, , https://www.who.int/ihr/about/en/, World Health Organization","Kickbusch, I.; Global Health Programme, Graduate Institute of International and Development StudiesSwitzerland; email: kickbusch@bluewin.ch",,BMJ Publishing Group,9598146,,BMJOA,32005675,English,BMJ,Editorial,Final,Open Access,Scopus,2-s2.0-85078832422,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Du Toit A.,56387020000;,Outbreak of a novel coronavirus,2020,Nature Reviews Microbiology,,,,,,,1,10.1038/s41579-020-0332-0,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078805550&doi=10.1038%2fs41579-020-0332-0&partnerID=40&md5=596067592bfd9a9c14b38abe42e322d9,"Nature Reviews Microbiology, United Kingdom","Du Toit, A., Nature Reviews Microbiology, United Kingdom",[No abstract available],,,,"Du Toit, A.; Nature Reviews MicrobiologyUnited Kingdom; email: nrmicro@nature.com",,Nature Research,17401526,,NRMAC,31988490,English,Nat. Rev. Microbiol.,Note,Article in Press,Open Access,Scopus,2-s2.0-85078805550,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Eurosurveillance Editorial Team,36440437500;,Note from the editors: novel coronavirus (2019-nCoV),2020,Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin,25,3,,,,,2,10.2807/1560-7917.ES.2020.25.3.2001231,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078688052&doi=10.2807%2f1560-7917.ES.2020.25.3.2001231&partnerID=40&md5=36f32586f33db81826efe872588f3d53,"European Centre for Disease Prevention and Control (ECDC)Stockholm, Sweden","Eurosurveillance Editorial Team, European Centre for Disease Prevention and Control (ECDC)Stockholm, Sweden",[No abstract available],coronavirus; public health event,"China; classification; communicable disease; Coronavirinae; Coronavirus infection; epidemic; human; virology; China; Communicable Diseases, Emerging; Coronavirus; Coronavirus Infections; Disease Outbreaks; Humans",,,,NLM (Medline),15607917,,,31992390,English,Euro Surveill.,Article,Final,Open Access,Scopus,2-s2.0-85078688052,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Callaway E., Cyranoski D.",23975660600;57208765775;,China coronavirus: Six questions scientists are asking,2020,Nature,577,7792,,605,607,,5,10.1038/d41586-020-00166-6,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078687659&doi=10.1038%2fd41586-020-00166-6&partnerID=40&md5=f74708082b7663f1aebd486d1605f0c0,,"Callaway, E.; Cyranoski, D.",[No abstract available],Epidemiology; Medical research; Virology,"anti human immunodeficiency virus agent; antivirus agent; COVID-19; virus vaccine; animal; asymptomatic infection; basic reproduction number; China; Coronavirinae; Coronavirus infection; Europe; genetics; human; isolation and purification; mortality; organization and management; pathogenicity; procedures; quarantine; severe acute respiratory syndrome; United States; virology; virus pneumonia; World Health Organization; zoonosis; Animals; Anti-HIV Agents; Antiviral Agents; Asymptomatic Infections; Basic Reproduction Number; China; Coronavirus; Coronavirus Infections; Europe; Humans; Pneumonia, Viral; Quarantine; Severe Acute Respiratory Syndrome; United States; Viral Vaccines; World Health Organization; Zoonoses",,,,NLM (Medline),14764687,,,31992880,English,Nature,Note,Final,Open Access,Scopus,2-s2.0-85078687659,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, [No author name available],[No author id available],Mysterious infections in China: Novel coronavirus identified as cause of pneumonia [Mysteriöse Infektionen in China],2020,Deutsche Apotheker Zeitung,160,3,,,,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078170838&partnerID=40&md5=a0f455075edd128f81699cc39cffc43d,,,[No abstract available],,Article; China; Coronavirinae; Coronavirus infection; nonhuman; Novel coronavirus; pneumonia,"(2020) Informationen Des RKI Zur Häufung Von Pneumonien in Wuhan, China, , www.rki.de, Stand 10. Januar; (2020) Pneumonia of Unknown Cause – China, , www.who.int, Disease outbreak news. 5 Januar; (2020) WHO Statement Regarding Cluster of Pneumonia Cases in Wuhan, , www.who.int, China. 9. Januar; (2020) Q & A on Coronaviruses, , www.who.int, 9. Januar; Pneumonia cases possibly associated with a novel coronavirus in Wuhan, China (2020) Risk Assessment, 9. , www.ecdc.europa.eu, Januar; PRO/AH/EDR > Undiagnosed Pneumonia – China (HU) (07): Official Confirmation of Novel Coronavirus, , https://promedmail.org; (2020) CHP Provides Further Information on Cluster of Pneumonia Cases in Wuhan, , www.info.gov.hk, Meldung vom 12. Januar HKT 20:03; Phylogenetic Analysis Shows Novel Wuhan Coronavirus Clusters with SARS, , www.ecohealthalliance.org; (2020) China: Reise- und Sicherheitshinweise, , www.auswaertiges-amt.de, Stand 13. Januar; Helmholtz-Zentrum Für Infektionsforschung (HZI), , www.helmholtz-hzi.de; MSD Manual – Ausgabe Für Medizinische Fachkreise, , www.msdmanuals.com",,,Deutscher Apotheker Verlag,119857,,DAZEA,,German,Dtsch. Apoth. Ztg.,Article,Final,,Scopus,2-s2.0-85078170838,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Al Mutair A., Ambani Z.",55224333100;57208129737;,Narrative review of Middle East respiratory syndrome coronavirus (MERS-CoV) infection: updates and implications for practice,2020,The Journal of international medical research,48,1,,,,,1,10.1177/0300060519858030,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077614988&doi=10.1177%2f0300060519858030&partnerID=40&md5=b60d55462ba4560353f8d4043005c6f0,"Research Center, Dr Sulaiman Al Habib Medical Group, Riyadh, Saudi Arabia; School of Nursing, Wollongong University, Australia; Alfaisal University, Riyadh, Saudi Arabia; King Saud Ben Abdulaziz University for Health Sciences, Al Ahsa, Riyadh, Eastern Province, Saudi Arabia","Al Mutair, A., Research Center, Dr Sulaiman Al Habib Medical Group, Riyadh, Saudi Arabia, School of Nursing, Wollongong University, Australia, Alfaisal University, Riyadh, Saudi Arabia; Ambani, Z., King Saud Ben Abdulaziz University for Health Sciences, Al Ahsa, Riyadh, Eastern Province, Saudi Arabia",[No abstract available],coronavirus; infection control and management; MERS CoV; Middle East respiratory syndrome coronavirus; respiratory illness; transmission,,,,,NLM (Medline),14732300,,,31256729,English,J. Int. Med. Res.,Article,Final,Open Access,Scopus,2-s2.0-85077614988,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Huan C., Pan H., Fu S., Xu W., Gao Q., Wang X., Gao S., Chen C., Liu X.",56118075000;57210573557;57210574859;57210569855;26657296700;35363148400;53063485900;57210574683;35362360500;,Characterization and evolution of the coronavirus porcine epidemic diarrhoea virus HLJBY isolated in China,2020,Transboundary and Emerging Diseases,67,1,,65,79,,,10.1111/tbed.13321,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85071010076&doi=10.1111%2ftbed.13321&partnerID=40&md5=0194cf667d3c86edffd768f8a2fcaa2b,"Institutes of Agricultural Science and Technology Development, College of Veterinary Medicine, Yangzhou University, Yangzhou, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China; Key Laboratory of Avian Bioproduct Development, Ministry of Agriculture and Rural Affairs, Yangzhou, China; Jiangsu Provincial Center for Animal Disease Control and Prevention, Nanjing, China","Huan, C., Institutes of Agricultural Science and Technology Development, College of Veterinary Medicine, Yangzhou University, Yangzhou, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China, Key Laboratory of Avian Bioproduct Development, Ministry of Agriculture and Rural Affairs, Yangzhou, China; Pan, H., Institutes of Agricultural Science and Technology Development, College of Veterinary Medicine, Yangzhou University, Yangzhou, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China, Key Laboratory of Avian Bioproduct Development, Ministry of Agriculture and Rural Affairs, Yangzhou, China; Fu, S., Institutes of Agricultural Science and Technology Development, College of Veterinary Medicine, Yangzhou University, Yangzhou, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China, Key Laboratory of Avian Bioproduct Development, Ministry of Agriculture and Rural Affairs, Yangzhou, China; Xu, W., Institutes of Agricultural Science and Technology Development, College of Veterinary Medicine, Yangzhou University, Yangzhou, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China, Key Laboratory of Avian Bioproduct Development, Ministry of Agriculture and Rural Affairs, Yangzhou, China; Gao, Q., Institutes of Agricultural Science and Technology Development, College of Veterinary Medicine, Yangzhou University, Yangzhou, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China, Key Laboratory of Avian Bioproduct Development, Ministry of Agriculture and Rural Affairs, Yangzhou, China; Wang, X., Institutes of Agricultural Science and Technology Development, College of Veterinary Medicine, Yangzhou University, Yangzhou, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China, Key Laboratory of Avian Bioproduct Development, Ministry of Agriculture and Rural Affairs, Yangzhou, China; Gao, S., Institutes of Agricultural Science and Technology Development, College of Veterinary Medicine, Yangzhou University, Yangzhou, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China, Key Laboratory of Avian Bioproduct Development, Ministry of Agriculture and Rural Affairs, Yangzhou, China; Chen, C., Jiangsu Provincial Center for Animal Disease Control and Prevention, Nanjing, China; Liu, X., Institutes of Agricultural Science and Technology Development, College of Veterinary Medicine, Yangzhou University, Yangzhou, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, China, Key Laboratory of Avian Bioproduct Development, Ministry of Agriculture and Rural Affairs, Yangzhou, China","A strain of porcine epidemic diarrhoea virus (PEDV), namely HLJBY, was isolated in Heilongjiang province, China. To provide insight into the understanding of the phylogenetic and the current epidemiological status of PEDV, PEDV HLJBY was compared with CV777 and other PEDV strains deposited in the GenBank. The homology between the entire genomic nucleotide sequences of PEDV HLJBY and CV777 was 97.7%. The homology of M gene was the highest (99.0%). However, the homology of ORF3 gene was 97.7%, and protein of ORF3 was 90.1%. In addition, HLJBY showed the highest nucleotide identity (99.9%) with PEDV-SX/China/2017 strain and lowest similarity (91.2%) to PEDV/Belgorod/dom/2008 strain. We analysed the changes in S gene and its protein of PEDV HLJBY with 65 historic PEDV strains. The highest nucleotide identity was 99.9% compared with PEDV-SX/China/2017 strain, and the lowest nucleotide identity was 60.0% compared with PEDV/Belgorod/dom/2008 strain. The length of deduced amino acid sequences of S proteins varied from 1,372 to 1,390 amino acids (aa). Compared with most aa sequences of S proteins, HLJBY exhibited 5 aa deletions (position 55, 59–61, 144). Analysis and comparison of open reading frame 3 (ORF3) proteins between HLJBY strain and other PEDV strains were also focused in this study. We revealed that the length of deduced amino acid sequences of ORF3 proteins was 80–224 aa among tested strains and the identity of HLJBY ORF3 amino acids with other PEDV strains was 71.4%–98.9%. ORF3 protein of both HLJBY strain and PEDV-SX/China/2017 strain consists of 91 aa, with 133 aa deletions at their C' end in relation to the other tested PEDV strains. The phylogenetic tree based on different proteins or genes resulted in different phylogenetic groups. For pathogenicity evaluation of PEDV HLJBY strain, colostrum deprivation piglets were challenged with PEDV HLJBY, and PEDV reference strain CV777 as a control, the results showed that animals challenged with either of these PEDV strains developed diarrhoea, and histopathological examination of small intestines of challenged animals showed acute viral enteritis with villous atrophy in either PEDV HLJBY-P10 or PEDV CV777-P8 inoculated piglets. © 2019 Blackwell Verlag GmbH",genomic sequence; HLJBY strain; open reading frame 3; phylogenetic analysis; porcine epidemic diarrhoea virus; S protein,vitronectin; amino acid sequence; animal cell; animal experiment; animal model; animal tissue; Article; bioinformatics; China; controlled study; diarrhea; epidemic; evolution; genetic recombination; genome analysis; genome-wide association study; immunofluorescence test; newborn; nonhuman; nucleotide sequence; open reading frame; pathogenicity; phylogeny; Porcine epidemic diarrhea virus; real time polymerase chain reaction; RNA extraction; sequence alignment; sequence analysis; vaccination; virus culture; virus isolation; virus strain; virus virulence,"Belouzard, S., Millet, J.K., Licitra, B.N., Whittaker, G.R., Mechanisms of coronavirus cell entry mediated by the viral spike protein (2012) Viruses, 4, pp. 1011-1033; Chae, C., Kim, O., Choi, C., Min, K., Cho, W.S., Kim, J., Tai, J.H., Prevalence of porcine epidemic diarrhoea virus and transmissible gastroenteritis virus infection in Korean pigs (2000) The Veterinary Record, 147, pp. 606-608; Chen, Q., Li, G., Stasko, J., Thomas, J.T., Stensland, W.R., Pillatzki, A.E., Zhang, J., Isolation and characterization of porcine epidemic diarrhea viruses associated with the 2013 disease outbreak among swine in the United States (2014) Journal of Clinical Microbiology, 52, pp. 234-243; Debouck, P., Pensaert, M., Experimental infection of pigs with a new porcine enteric coronavirus, CV 777 (1980) American Journal of Veterinary Research, 41, pp. 219-223; Gerber, P.F., Gong, Q., Huang, Y.W., Wang, C., Holtkamp, D., Opriessnig, T., Detection of antibodies against porcine epidemic diarrhea virus in serum and colostrum by indirect ELISA (2014) Veterinary Journal, 202, pp. 33-36; Kocherhans, R., Bridgen, A., Ackermann, M., Tobler, K., Completion of the porcine epidemic diarrhoea coronavirus (PEDV) genome sequence (2001) Virus Genes, 23, pp. 137-144; Lee, C., Porcine epidemic diarrhea virus: An emerging and re-emerging epizootic swine virus (2015) Virology Journal, 12, p. 193; Lee, D.K., Park, C.K., Kim, S.H., Lee, C., Heterogeneity in spike protein genes of porcine epidemic diarrhea viruses isolated in Korea (2010) Virus Research, 149, pp. 175-182; Lee, S., Lee, C., Outbreak-related porcine epidemic diarrhea virus strains similar to US strains, South Korea, 2013 (2014) Emerging Infectious Diseases, 20, pp. 1223-1226; Li, W., Li, H., Liu, Y., Pan, Y., Deng, F., Song, Y., He, Q., New variants of porcine epidemic diarrhea virus, China, 2011 (2012) Emerging Infectious Diseases, 18, pp. 1350-1353; Lowe, J., Gauger, P., Harmon, K., Zhang, J., Connor, J., Yeske, P., Main, R., Role of transportation in spread of porcine epidemic diarrhea virus infection, United States (2014) Emerging Infectious Diseases, 20, pp. 872-874. , https://doi.org/10.3201/eid2005.131628; Mole, B., Deadly pig virus slips through US borders (2013) Nature, 499, p. 388. , https://doi.org/10.1038/499388a; Oh, J., Lee, K.W., Choi, H.W., Lee, C., Immunogenicity and protective efficacy of recombinant S1 domain of the porcine epidemic diarrhea virus spike protein (2014) Archives of Virology, 159, pp. 2977-2987. , https://doi.org/10.1007/s00705-014-2163-7; Olanratmanee, E.O., Kunavongkrit, A., Tummaruk, P., Impact of porcine epidemic diarrhea virus infection at different periods of pregnancy on subsequent reproductive performance in gilts and sows (2010) Animal Reproduction Science, 122, pp. 42-51. , https://doi.org/10.1016/j.anireprosci.2010.07.004; Park, S.J., Moon, H.J., Luo, Y., Kim, H.K., Kim, E.M., Yang, J.S., Park, B.K., Cloning and further sequence analysis of the ORF3 gene of wild- and attenuated-type porcine epidemic diarrhea viruses (2008) Virus Genes, 36, pp. 95-104. , https://doi.org/10.1007/s11262-007-0164-2; Pensaert, M.B., de Bouck, P., A new coronavirus-like particle associated with diarrhea in swine (1978) Archives of Virology, 58, pp. 243-247. , https://doi.org/10.1007/BF01317606; Pijpers, A., van Nieuwstadt, A.P., Terpstra, C., Verheijden, J.H., Porcine epidemic diarrhoea virus as a cause of persistent diarrhoea in a herd of breeding and finishing pigs (1993) The Veterinary Record, 132, pp. 129-131. , https://doi.org/10.1136/vr.132.6.129; Stevenson, G.W., Hoang, H., Schwartz, K.J., Burrough, E.R., Sun, D., Madson, D., Yoon, K.J., Emergence of porcine epidemic diarrhea virus in the United States: Clinical signs, lesions, and viral genomic sequences (2013) Journal of Veterinary Diagnostic Investigation: Official Publication of the American Association of Veterinary Laboratory Diagnosticians Inc, 25, pp. 649-654; Sun, R.Q., Cai, R.J., Chen, Y.Q., Liang, P.S., Chen, D.K., Song, C.X., Outbreak of porcine epidemic diarrhea in suckling piglets, China (2012) Emerging Infectious Diseases, 18, pp. 161-163. , https://doi.org/10.3201/eid1801.111259; Temeeyasen, G., Srijangwad, A., Tripipat, T., Tipsombatboon, P., Piriyapongsa, J., Phoolcharoen, W., Nilubol, D., Genetic diversity of ORF3 and spike genes of porcine epidemic diarrhea virus in Thailand (2014) Infection, Genetics and Evolution: Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases, 21, pp. 205-213. , https://doi.org/10.1016/j.meegid.2013.11.001; Thompson, J.D., Gibson, T.J., Plewniak, F., Jeanmougin, F., Higgins, D.G., The CLUSTAL_X windows interface: Flexible strategies for multiple sequence alignment aided by quality analysis tools (1997) Nucleic Acids Research, 25, pp. 4876-4882. , https://doi.org/10.1093/nar/25.24.4876; Vlasova, A.N., Marthaler, D., Wang, Q., Culhane, M.R., Rossow, K.D., Rovira, A., Saif, L.J., Distinct characteristics and complex evolution of PEDV strains, North America, may 2013-February 2014 (2014) Emerging Infectious Diseases, 20, pp. 1620-1628. , https://doi.org/10.3201/eid2010.140491; Wang, K., Lu, W., Chen, J., Xie, S., Shi, H., Hsu, H., Sun, B., PEDV ORF3 encodes an ion channel protein and regulates virus production (2012) FEBS Letters, 586, pp. 384-391. , https://doi.org/10.1016/j.febslet.2012.01.005","Gao, S.; Institutes of Agricultural Science and Technology Development, College of Veterinary Medicine, Yangzhou UniversityChina; email: gsong@yzu.edu.cn",,Blackwell Publishing Ltd,18651674,,,31381232,English,Transboundary Emer. Dis.,Article,Final,Open Access,Scopus,2-s2.0-85071010076,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Hsih W.-H., Cheng M.-Y., Ho M.-W., Chou C.-H., Lin P.-C., Chi C.-Y., Liao W.-C., Chen C.-Y., Leong L.-Y., Tien N., Lai H.-C., Lai Y.-C., Lu M.-C.",57215874033;57215873944;8325831100;36637021400;51964312300;7401898834;55945369900;56162257700;57211562067;35338097400;57211212039;36142302300;57154844900;,Featuring COVID-19 cases via screening symptomatic patients with epidemiologic link during flu season in a medical center of central Taiwan,2020,"Journal of Microbiology, Immunology and Infection",,,,,,,,10.1016/j.jmii.2020.03.008,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082180786&doi=10.1016%2fj.jmii.2020.03.008&partnerID=40&md5=26ba4b57ea4411be3b75c4cf85700f81,"Division of Infectious Diseases, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan; Division of Pulmonary and Critical Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan; Department of Laboratory Medicine, China Medical University Hospital, No. 2 Yu-Der Rd, North District, Taichung, Taiwan; Division of Pediatric Infectious Diseases, China Medical University Children's Hospital, China Medical University, Taichung, Taiwan; Department of Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan; Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan; Department of Microbiology and Immunology, School of Medicine, China Medical University, Taichung, Taiwan","Hsih, W.-H., Division of Infectious Diseases, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan; Cheng, M.-Y., Division of Infectious Diseases, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan; Ho, M.-W., Division of Infectious Diseases, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan; Chou, C.-H., Division of Infectious Diseases, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan; Lin, P.-C., Division of Infectious Diseases, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan; Chi, C.-Y., Division of Infectious Diseases, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan; Liao, W.-C., Division of Pulmonary and Critical Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan; Chen, C.-Y., Division of Pulmonary and Critical Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan; Leong, L.-Y., Division of Infectious Diseases, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan; Tien, N., Department of Laboratory Medicine, China Medical University Hospital, No. 2 Yu-Der Rd, North District, Taichung, Taiwan; Lai, H.-C., Division of Pediatric Infectious Diseases, China Medical University Children's Hospital, China Medical University, Taichung, Taiwan; Lai, Y.-C., Department of Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan; Lu, M.-C., Division of Infectious Diseases, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan, Department of Microbiology and Immunology, School of Medicine, China Medical University, Taichung, Taiwan","Background: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CO-V-2), was first reported in Wuhan, Hubei province, China has now rapidly spread over 50 countries. For the prevention and control of infection, Taiwan Centers for Disease Control initiated testing of SARS-CoV-2 on January 24th 2020 for persons suspected with this disease. Until February 28th, 43 flu-like symptomatic patients were screened in China Medical University Hospital. Methods: Two patients were confirmed positive for SARS-CoV-2 infection by rRT-PCR as COVID-19 patients A and B. Causative pathogens for included patients were detected using FilmArray™ Respiratory Panel. We retrospectively analyzed the clinical presentations, laboratory data, radiologic findings, and travel and exposure contact histories, of the COVID-19 patients in comparison to those with other respiratory infections. Results: Through contact with Taiwan No. 19 case patient on 27th January, COVID-19 patients A and B were infected. Both patients had no identified comorbidities and developed mild illness with temporal fever, persistent cough, and lung interstitial infiltrates. Owing to the persistence of positive SARS-CoV-2 in respiratory specimen, the two COVID-19 patients are still in the isolation rooms despite recovery until 10th of March. The results of FilmArrayTM Respiratory Panel revealed 22 of the 41 non-COVID-19 patients were infected by particular pathogens. In general, seasonal respiratory pathogens are more prevalent than SARS-CoV-2 in symptomatic patients in non- COVID-19 endemic area during the flu season. Since all patients shared similar clinical and laboratory findings, expanded surveillance of detailed exposure history for suspected patients and application of rapid detection tools are highly recommended. © 2020",COVID-19; FilmArray™ Respiratory Panel; SARS-CO-V-2,,"Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382 (8), pp. 727-733; Lu, R., Zhao, X., Li, J., Niu, P., Yang, B., Wu, H., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet, 395 (10224), pp. 565-574; Guan, W.J., Ni, Z.Y., Hu, Y., Liang, W.H., Ou, C.Q., He, J.X., Clinical characteristics of 2019 novel coronavirus disease in China (2020) N Engl J Med, , https://DOI:10.1056/NEJMoa2002032; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395 (10223), pp. 497-506; Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) Jama, , https://doi:10.1001/jama.2020.1585; Corman, V.M., Landt, O., Kaiser, M., Molenkamp, R., Meijer, A., Chu, D.K.W., Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR (2020) Euro Surveill, 25 (3). , https://doi:10.2807/1560-7917.ES.2020.25.3.2000045; Huang, H.S., Tsai, C.L., Chang, J., Hsu, T.C., Lin, S., Lee, C.C., Multiplex PCR system for the rapid diagnosis of respiratory virus infection: systematic review and meta-analysis (2018) Clin Microbiol Infect, 24 (10), pp. 1055-1063; Poritz, M.A., Blaschke, A.J., Byington, C.L., Meyers, L., Nilsson, K., Jones, D.E., FilmArray, an automated nested multiplex PCR system for multi-pathogen detection: development and application to respiratory tract infection (2011) PloS One, 6 (10). , https://doi:10.1371/journal.pone.0026047; Lee, S.H., Ruan, S.Y., Pan, S.C., Lee, T.F., Chien, J.Y., Hsueh, P.R., Performance of a multiplex PCR pneumonia panel for the identification of respiratory pathogens and the main determinants of resistance from the lower respiratory tract specimens of adult patients in intensive care units (2019) J Microbiol Immunol Infect, 52 (6), pp. 920-928; Hui, D.S., Review of clinical symptoms and spectrum in humans with influenza A/H5N1 infection (2008) Respirology, 13, pp. S10-S13; Litwin, C.M., Bosley, J.G., Seasonality and prevalence of respiratory pathogens detected by multiplex PCR at a tertiary care medical center (2014) Arch Virol, 159 (1), pp. 65-72; Holshue, M.L., DeBolt, C., Lindquist, S., Lofy, K.H., Wiesman, J., Bruce, H., First case of 2019 novel coronavirus in the United States (2020) N Engl J Med, 382 (10), pp. 929-936; Lee, P.I., Hsueh, P.R., Emerging threats from zoonotic coronaviruses-from SARS and MERS to 2019-nCoV (2020) J Microbiol Immunol Infect, , https://doi:10.1016/j.jmii.2020.02.001; Lai, C.C., Shih, T.P., Ko, W.C., Tang, H.J., Hsueh, P.R., Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and corona virus disease-2019 (COVID-19): the epidemic and the challenges (2020) Int J Antimicrob Agents, , https://doi:10.1016/j.ijantimicag.2020.105924; Lipsitch, M., Swerdlow, D.L., Finelli, L., Defining the epidemiology of Covid-19—studies needed (2020) N Engl J Med, , https://doi:10.1056/NEJMp2002125; Rothe, C., Schunk, M., Sothmann, P., Bretzel, G., Froeschl, G., Wallrauch, C., Transmission of 2019-nCoV infection from an asymptomatic contact in Germany (2020) N Engl J Med, 382 (10), pp. 970-971; Liu, Y., Gayle, A.A., Wilder-Smith, A., Rocklöv, J., The reproductive number of COVID-19 is higher compared to SARS coronavirus (2020) J Trav Med, , https://doi:10.1093/jtm/taaa021; Hon, K.L., Severe respiratory syndromes: travel history matters (2013) Trav Med Infect Dis, 11 (5), pp. 285-287; Lan, L., Xu, D., Ye, G., Xia, C., Wang, S., Li, Y., Positive RT-PCR test results in patients recovered from COVID-19 (2020) Jama, , https://doi:10.1001/jama.2020.2783; Gu, J., Han, B., Wang, J., COVID-19: gastrointestinal manifestations and potential fecal-oral transmission (2020) Gastroenterology, , https://doi:10.1053/j.gastro.2020.02.054","Lu, M.-C.; Department of Microbiology and Immunology, School of Medicine, China Medical, University, No.91, Hsueh-Shih Road, Taiwan; email: luminchi@outlook.com",,Elsevier Ltd,16841182,,JMIIF,,English,J. Microbiol. Immunol. Infect.,Article,Article in Press,Open Access,Scopus,2-s2.0-85082180786,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Chen R., Zhang Y., Huang L., Cheng B.-H., Xia Z.-Y., Meng Q.-T.",56925751400;57215724423;57215037016;57200537730;57215720641;57215722870;,Safety and efficacy of different anesthetic regimens for parturients with COVID-19 undergoing Cesarean delivery: a case series of 17 patients [Sécurité et efficacité de différents modes d’anesthésie pour des parturientes infectées par la COVID-19 accouchant par césarienne : une série de 17 cas],2020,Canadian Journal of Anesthesia,,,,,,,,10.1007/s12630-020-01630-7,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081731028&doi=10.1007%2fs12630-020-01630-7&partnerID=40&md5=a6eee38c7d5dcea976684a90a8058cff,"Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China; Department of Anesthesiology, East Hospital, Renmin Hospital of Wuhan University, Wuhan, China; Department of Obstetric, East Hospital, Renmin Hospital of Wuhan University, Wuhan, China","Chen, R., Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China, Department of Anesthesiology, East Hospital, Renmin Hospital of Wuhan University, Wuhan, China; Zhang, Y., Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China, Department of Anesthesiology, East Hospital, Renmin Hospital of Wuhan University, Wuhan, China; Huang, L., Department of Anesthesiology, East Hospital, Renmin Hospital of Wuhan University, Wuhan, China; Cheng, B.-H., Department of Obstetric, East Hospital, Renmin Hospital of Wuhan University, Wuhan, China; Xia, Z.-Y., Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China; Meng, Q.-T., Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, 430060, China, Department of Anesthesiology, East Hospital, Renmin Hospital of Wuhan University, Wuhan, China","Purpose: To assess the management and safety of epidural or general anesthesia for Cesarean delivery in parturients with coronavirus disease (COVID-19) and their newborns, and to evaluate the standardized procedures for protecting medical staff. Methods: We retrospectively reviewed the cases of parturients diagnosed with severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection disease (COVID-19). Their epidemiologic history, chest computed tomography scans, laboratory measurements, and SARS-CoV-2 nucleic acid positivity were evaluated. We also recorded the patients’ demographic and clinical characteristics, anesthesia and surgery-related data, maternal and neonatal complications, as well as the health status of the involved medical staff. Results: The clinical characteristics of 17 pregnant women infected with SARS-CoV-2 were similar to those previously reported in non-pregnant adult patients. All of the 17 patients underwent Cesarean delivery with anesthesia performed according to standardized anesthesia/surgery procedures. Fourteen of the patients underwent continuous epidural anesthesia with 12 experiencing significant intraoperative hypotension. Three patients received general anesthesia with tracheal intubation because emergency surgery was needed. Three of the parturients are still recovering from their Cesarean delivery and are receiving in-hospital treatment for COVID-19. Three neonates were born prematurely. There were no deaths or serious neonatal asphyxia events. All neonatal SARS-CoV-2 nucleic acid tests were negative. No medical staff were infected throughout the patient care period. Conclusions: Both epidural and general anesthesia were safely used for Cesarean delivery in the parturients with COVID-19. Nevertheless, the incidence of hypotension during epidural anesthesia appeared excessive. Proper patient transfer, medical staff access procedures, and effective biosafety precautions are important to protect medical staff from COVID-19. © 2020, Canadian Anesthesiologists' Society.",,,"Yang, X., Yu, Y., Xu, J., Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study (2020) Lancet Respir Med; Xu, X.W., Wu, X.X., Jiang, X.G., Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series (2019) BMJ; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506. , COI: 1:CAS:528:DC%2BB3cXhs1Kqu7c%3D; Wax, R.S., Christian, M.D., Practical recommendations for critical care and anesthesiology teams caring for novel coronavirus (2019-nCoV) patients (2020) Can J Anesth; Chen, R., Chen, J., Meng, Q., Chest computed tomography images of early coronavirus disease (COVID-19) (2020) Can J Anesth; Lee, N., Hui, D., Wu, A., A major outbreak of severe acute respiratory syndrome in Hong Kong (2003) N Engl J Med, 348, pp. 1986-1994; Assiri, A., Al-Tawfiq, J.A., Al-Rabeeah, A.A., Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study (2013) Lancet Infect Dis, 13, pp. 752-761; Wang, D., Hu, B., Hu, C., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2019) JAMA; Chen, H., Guo, J., Wang, C., Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records (2020) Lancet; Gagneur, A., Dirson, E., Audebert, S., Vertical transmission of human coronavirus. Prospective pilot study (French) (2007) Pathol Biol (Paris), 55, pp. 525-530. , COI: 1:STN:280:DC%2BD1c%2Fgt1Oqtw%3D%3D; Fan, C., Li, K., Ding, Y., Lu, W.L., Wang, J., ACE2 expression in kidney and testis may cause kidney and testis damage after 2019-nCoV infection (2020) Urology; Birnbach, D.J., Bateman, B.T., Obstetric anesthesia: leading the way in patient safety (2019) Obstet Gynecol Clin N Am, 46, pp. 329-337; Zhou, P., Yang, X.L., Wang, X.G., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature; Lu, R., Zhao, X., Li, J., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2019) Lancet","Meng, Q.-T.; Department of Anesthesiology, Renmin Hospital of Wuhan UniversityChina; email: mengqingtao2018@126.com",,Springer,0832610X,,CJOAE,,English,Can. J. Anesth.,Article,Article in Press,Open Access,Scopus,2-s2.0-85081731028,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Sayed A.S.M., Malek S.S., Abushahba M.F.N.",36828154500;56659187500;56958561300;,Seroprevalence of Middle East Respiratory Syndrome Corona Virus in dromedaries and their traders in upper Egypt,2020,Journal of Infection in Developing Countries,14,2,,191,198,,,10.3855/jidc.10862,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081693941&doi=10.3855%2fjidc.10862&partnerID=40&md5=0de0ad2087b8e5126890f66b755967df,"Department of Zoonoses, Faculty of Veterinary Medicine, Assiut University, Asyut, 71526, Egypt; Department of Animal Medicine, Faculty of Veterinary Medicine, Assiut University, Asyut, Egypt","Sayed, A.S.M., Department of Zoonoses, Faculty of Veterinary Medicine, Assiut University, Asyut, 71526, Egypt; Malek, S.S., Department of Animal Medicine, Faculty of Veterinary Medicine, Assiut University, Asyut, Egypt; Abushahba, M.F.N., Department of Zoonoses, Faculty of Veterinary Medicine, Assiut University, Asyut, 71526, Egypt","Introduction: Camel trade in Egypt depends mainly on importation. Seemingly healthy imported camels are responsible for the ingress of serious diseases into Egypt. A striking example of this concerning public health globally is the Middle East respiratory coronavirus (MERS-CoV) which causes case fatalities of over 34%. Here, we determined the seroepidemiological situation of the MERS-CoV in imported camels and their traders in Upper Egypt. Methodology: Sera of sixty-three dromedaries and twenty-eight camel traders were recruited (January 2015-December 2016). The age, gender, and sampling locality of each sampled camel and human were obtained. Semi-quantitative anti-MERS-CoV IgG ELISAs which utilize the purified spike protein domain S1 antigen of MERS coronavirus (MERS-CoV S1) were used to detect specific IgG antibodies against the virus. Results: The data showed that 58.73% of imported camels and 25% of traders had antibodies specific to MERS-CoV. Interestingly, like seroreactive camels, all seropositive humans were apparently healthy without any history of developing severe respiratory disease in the 14 days prior to sampling. Having specific antibodies among the examined camel sera was significantly different (P < 0.0001) in relation to various sampling localities, gender and age groups. In contrast, the seropositivity rate of MERS-CoV IgG in humans did not differ significantly by any of the studied factors. Conclusions: The current study provides the first serological evidence of occupational exposure of humans to MERS-CoV in Africa. Additionally, it reports that imported camels could be implicated in introducing MERS-CoV into Egypt. Accordingly, application of strict control measures to camel importation is a priority. © 2020 Sayed et al.",Dromedary camels; ELISA; MERS-CoV; Zoonosis,immunoglobulin G antibody; virus antibody; virus spike protein; adult; Article; cohort analysis; dromedary; Egypt; enzyme linked immunosorbent assay; exposure; female; human; infection rate; male; Middle East respiratory syndrome; Middle East respiratory syndrome coronavirus; nonhuman; seroprevalence,"Drosten, C., Seilmaier, M., Corman, V.M., Hartmann, W., Scheible, G., Sack, S., Guggemos, W., Wendtner, C.-M., Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection (2013) Lancet Infect Dis, 13, pp. 745-751; (2019) Middle East Respiratory Syndrome Coronavirus (MERS-CoV) (2019), , https://www.who.int/emergencies/mers-cov/en/, World Health Organization, Geneva, WHO, Accessed 19 September 2019; Omrani, A.S., Al-Tawfiq, J.A., Memish, Z.A., Middle East respiratory syndrome coronavirus (MERS-CoV): Animal to human interaction (2015) Pathog Glob Health, 109, pp. 354-362; Farag, E.A.B.A., Reusken, C.B.E.M., Haagmans, B.L., Mohran, K.A., Stalin Raj, V., Pas, S.D., Voermans, J., Koopmans, M.P.G., High proportion of MERS-CoV shedding dromedaries at slaughterhouse with a potential epidemiological link to human cases, Qatar 2014 (2015) Infect Ecol Epidemiol, 5, p. 28305; Chu, D.K.W., Oladipo, J.O., Perera, R.A.P.M., Kuranga, S.A., Chan, S.M.S., Poon, L.L.M., Peiris, M., Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Nigeria, 2015 (2015) Euro Surveill, 20, p. 30086; Nowotny, N., Kolodziejek, J., Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels, Oman, 2013 (2014) Euro Surveill, 19, p. 20781; Ali, M.A., Shehata, M.M., Gomaa, M.R., Kandeil, A., El-Shesheny, R., Kayed, A.S., El-Taweel, A.N., Kayali, G., Systematic, active surveillance for Middle East respiratory syndrome coronavirus in camels in Egypt (2017) Emerg Microbes Infect, 6, pp. 1-7; Van Doremalen, N., Hijazeen, Z.S.K., Holloway, P., Al Omari, B., McDowell, C., Adney, D., Talafha, H.A., Richt, J.A., High prevalence of middle east respiratory coronavirus in young dromedary camels in Jordan (2017) Vector-Borne Zoonotic Dis, 17, pp. 155-159; Ali, M., El-Shesheny, R., Kandeil, A., Shehata, M., Elsokary, B., Gomaa, M., Hassan, N., Makonnen, Y.J., Cross-sectional surveillance of Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels and other mammals in Egypt, August 2015 to January 2016 (2017) Eurosurveillance, 22, p. 30487; Ommeh, S., Zhang, W., Zohaib, A., Chen, J., Zhang, H., Hu, B., Ge, X.-Y., Shi, Z.-L., Genetic Evidence of Middle East Respiratory Syndrome Coronavirus (MERS-Cov) and Widespread Seroprevalence among Camels in Kenya (2018) Virol Sin, 33, pp. 484-492; Müller, M.A., Corman, V.M., Jores, J., Meyer, B., Younan, M., Liljander, A., Bosch, B.-J., Drosten, C., MERS Coronavirus Neutralizing Antibodies in Camels, Eastern Africa, 1983-1997 (2014) Emerg Infect Dis, 20, pp. 2093-2095; Falzarano, D., Kamissoko, B., De Wit, E., Maïga, O., Cronin, J., Samaké, K., Traoré, A., Feldmann, H., Dromedary camels in northern Mali have high seropositivity to MERS-CoV (2017) One Heal, 3, pp. 41-43; Kasem, S., Qasim, I., Al-Hufofi, A., Hashim, O., Alkarar, A., Abu-Obeida, A., Gaafer, A., Perera, R.A.P.M., Cross-sectional study of MERS-CoV-specific RNA and antibodies in animals that have had contact with MERS patients in Saudi Arabia (2018) J Infect Public Health, 11, pp. 331-338; 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Kandeil, A., Gomaa, M., Nageh, A., Shehata, M.M., Kayed, A.E., Sabir, J.S.M., Abiadh, A., Kayali, G., Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Dromedary Camels in Africa and Middle East (2019) Viruses, 11, p. 717; Gossner, C., Danielson, N., Gervelmeyer, A., Berthe, F., Faye, B., Kaasik Aaslav, K., Adlhoch, C., Coulombier, D., Human-dromedary camel interactions and the risk of acquiring zoonotic middle east respiratory syndrome coronavirus infection (2016) Zoonoses Public Health, 63, pp. 1-9; Assiri, A., McGeer, A., Perl, T.M., Price, C.S., Al Rabeeah, A.A., Cummings, D.A.T., Alabdullatif, Z.N., Memish, Z.A., Hospital outbreak of middle east respiratory syndrome coronavirus (2013) N Engl J Med, 369, pp. 407-416. , KSA MERS-CoV Investigation Team; Perera, R., Wang, P., Gomaa, M., El-Shesheny, R., Kandeil, A., Bagato, O., Siu, L., Kayali, G., Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt, June 2013 (2013) Eurosurveillance, 18, p. 20574; Chu, D.K.W., Poon, L.L.M., Gomaa, M.M., Shehata, M.M., Perera, R.A.P.M., Abu Zeid, D., El Rifay, A.S., Kayali, G., MERS coronaviruses in dromedary camels, Egypt (2014) Emerg Infect Dis, 20, pp. 1049-1053; Charan, J., Biswas, T., How to calculate sample size for different study designs in medical research? (2013) Indian J Psychol Med, 35, pp. 121-126; Ko, J.-H., Müller, M.A., Seok, H., Park, G.E., Lee, J.Y., Cho, S.Y., Ha, Y.E., Peck, K.R., Suggested new breakpoints of anti-MERS-CoV antibody ELISA titers: Performance analysis of serologic tests (2017) Eur J Clin Microbiol Infect Dis, 36, pp. 2179-2186; Alagaili, A.N., Briese, T., Mishra, N., Kapoor, V., Sameroff, S.C., De Wit, E., Munster, V.J., Lipkin, W.I., Middle east respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia (2014) MBio, 5, pp. e00884-e00914; Mohd, H.A., Al-Tawfiq, J.A., Memish, Z.A., Middle east respiratory syndrome coronavirus (mers-cov) origin and animal reservoir (2016) Virol J, 13, p. 87; Lattwein, E., Corman, V.M., Widdowson, M.-A., Njenga, M.K., Murithi, R., Osoro, E., Müller, M.A., Meyer, B., No serologic evidence of middle east respiratory syndrome coronavirus infection among camel farmers exposed to highly seropositive camel herds: A household linked study, Kenya, 2013 (2017) Am J Trop Med Hyg, 96, pp. 1318-1324; So, R.T., Perera, R.A., Oladipo, J.O., Chu, D.K., Kuranga, S.A., Chan, K.-H., Lau, E.H., Peiris, M., Lack of serological evidence of Middle East respiratory syndrome coronavirus infection in virus exposed camel abattoir workers in Nigeria, 2016 (2018) Euro Surveill, 23, p. 800175; Chu, D.K.W., Hui, K.P.Y., Perera, R.A.P.M., Miguel, E., Niemeyer, D., Zhao, J., Channappanavar, R., Peiris, M., MERS coronaviruses from camels in Africa exhibit region-dependent genetic diversity (2018) Proc Natl Acad Sci U S A, 115, pp. 3144-3149; Aburizaiza, A.S., Mattes, F.M., Azhar, E.I., Hassan, A.M., Memish, Z.A., Muth, D., Meyer, B., Drosten, C., Investigation of anti-middle east respiratory syndrome antibodies in blood donors and slaughterhouse workers in jeddah and makkah, Saudi Arabia, fall 2012 (2014) J Infect Dis, 209, pp. 243-246; Memish, Z.A., Alsahly, A., Al M.M, Heil, G.L., Anderson, B.D., Peiris, M., Khan, S.U., Gray, G.C., Sparse evidence of MERS-CoV infection among animal workers living in Southern Saudi Arabia during 2012 (2015) Influenza Other Respi Viruses, 9, pp. 64-67; Hemida, M.G., Al-Naeem, A., Perera, R.A.P.M., Chin, A.W.H., Poon, L.L.M., Peiris, M., Lack of middle east respiratory syndrome coronavirus transmission from infected camels (2015) Emerg Infect Dis, 21, pp. 699-701; Wernery, U., Lau, S.K.P., Woo, P.C.Y., Middle East respiratory syndrome (MERS) coronavirus and dromedaries (2017) Vet J, 220, pp. 75-79; Oboho, I.K., Tomczyk, S.M., Al-Asmari, A.M., Banjar, A.A., Al-Mugti, H., Aloraini, M.S., Alkhaldi, K.Z., Madani, T.A., 2014 mers-cov outbreak in jeddah - A link to health care facilities (2015) N Engl J Med, 372, pp. 846-854; State of knowledge and data gaps of middle east respiratory syndrome coronavirus (mers-cov) in humans (2013) PLoS Curr, 5. , ecurrents.outbreaks.0bf719e352e7478f8ad85fa30127ddb8., The WHO MERS-CoV Research Group; Arabi, Y.M., Arifi, A.A., Balkhy, H.H., Najm, H., Aldawood, A.S., Ghabashi, A., Hawa, H., Al Raiy, B., Clinical course and outcomes of critically ill patients with middle east respiratory syndrome coronavirus infection (2014) Ann Intern Med, 160, pp. 389-397; Drosten, C., Meyer, B., Müller, M.A., Corman, V.M., Al-Masri, M., Hossain, R., Madani, H., Memish, Z.A., Transmission of mers-coronavirus in household contacts (2014) N Engl J Med, 371, pp. 828-835; Memish, Z.A., Al-Tawfiq, J.A., Assiri, A., AlRabiah, F.A., Al Hajjar, S., Albarrak, A., Flemban, H., Al-Rabeeah, A.A., Middle east respiratory syndrome coronavirus disease in children (2014) Pediatr Infect Dis J, 33, pp. 904-906; Amer, H., Alqahtani, A.S., Alaklobi, F., Altayeb, J., Memish, Z.A., Healthcare worker exposure to Middle East respiratory syndrome coronavirus (MERS-CoV): Revision of screening strategies urgently needed (2018) Int J Infect Dis, 71, pp. 113-116; Alghamdi, I., Hussain, I., Alghamdi, M., Almalki, S., Alghamdi, M., Elsheemy, M., The pattern of Middle East respiratory syndrome coronavirus in Saudi Arabia: A descriptive epidemiological analysis of data from the Saudi Ministry of Health (2014) Int J Gen Med, 7, pp. 417-423","Abushahba, M.F.N.; Department of Zoonoses, Faculty of Veterinary Medicine, Assiut UniversityEgypt; email: mateya@aun.edu.eg",,Journal of Infection in Developing Countries,20366590,,,32146454,English,J. Infect. Dev. Ctries.,Article,Final,Open Access,Scopus,2-s2.0-85081693941,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Kandeel M., Ibrahim A., Fayez M., Al-Nazawi M.",22937486100;39461381900;57201602518;12765916000;,From SARS and MERS CoVs to SARS-CoV-2: Moving toward more biased codon usage in viral structural and nonstructural genes,2020,Journal of Medical Virology,,,,,,,,10.1002/jmv.25754,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081579482&doi=10.1002%2fjmv.25754&partnerID=40&md5=ed78569b78af041582b23c412ee6754e,"Department of Biomedical Sciences, College of Veterinary Medicine, King Faisal University, Al-hofuf, Egypt; Department of Pharmacology, Faculty of Veterinary Medicine, Kafrelshikh University, Kafrelshikh, Egypt; Department of Pathology, College of Veterinary Medicine, King Faisal University, Al-hofuf, Saudi Arabia; Department of Pathology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt; Al Ahsa Veterinary Diagnostic Laboratory, Ministry of Agriculture, Al-Ahsa, Saudi Arabia; Veterinary Serum and Vaccine Institute, Cairo, Egypt","Kandeel, M., Department of Biomedical Sciences, College of Veterinary Medicine, King Faisal University, Al-hofuf, Egypt, Department of Pharmacology, Faculty of Veterinary Medicine, Kafrelshikh University, Kafrelshikh, Egypt; Ibrahim, A., Department of Pathology, College of Veterinary Medicine, King Faisal University, Al-hofuf, Saudi Arabia, Department of Pathology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt; Fayez, M., Al Ahsa Veterinary Diagnostic Laboratory, Ministry of Agriculture, Al-Ahsa, Saudi Arabia, Veterinary Serum and Vaccine Institute, Cairo, Egypt; Al-Nazawi, M., Department of Biomedical Sciences, College of Veterinary Medicine, King Faisal University, Al-hofuf, Egypt","Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging disease with fatal outcomes. In this study, a fundamental knowledge gap question is to be resolved by evaluating the differences in biological and pathogenic aspects of SARS-CoV-2 and the changes in SARS-CoV-2 in comparison with the two prior major COV epidemics, SARS and Middle East respiratory syndrome (MERS) coronaviruses. Methods: The genome composition, nucleotide analysis, codon usage indices, relative synonymous codons usage, and effective number of codons (ENc) were analyzed in the four structural genes; Spike (S), Envelope (E), membrane (M), and Nucleocapsid (N) genes, and two of the most important nonstructural genes comprising RNA-dependent RNA polymerase and main protease (Mpro) of SARS-CoV-2, Beta-CoV from pangolins, bat SARS, MERS, and SARS CoVs. Results: SARS-CoV-2 prefers pyrimidine rich codons to purines. Most high-frequency codons were ending with A or T, while the low frequency and rare codons were ending with G or C. SARS-CoV-2 structural proteins showed 5 to 20 lower ENc values, compared with SARS, bat SARS, and MERS CoVs. This implies higher codon bias and higher gene expression efficiency of SARS-CoV-2 structural proteins. SARS-CoV-2 encoded the highest number of over-biased and negatively biased codons. Pangolin Beta-CoV showed little differences with SARS-CoV-2 ENc values, compared with SARS, bat SARS, and MERS CoV. Conclusion: Extreme bias and lower ENc values of SARS-CoV-2, especially in Spike, Envelope, and Mpro genes, are suggestive for higher gene expression efficiency, compared with SARS, bat SARS, and MERS CoVs. © 2020 Wiley Periodicals, Inc.",codon bias; COVID-19; MERS CoV; nonstructural protein; preferred codons; SARS-CoV-2,,"Velavan, T.P., Meyer, C.G., The COVID-19 epidemic (2020) Trop Med Int Health, 25, pp. 278-280. , https://doi.org/10.1111/tmi.13383; Wang, Y., Kang, H., Liu, X., Tong, Z., Combination of RT-qPCR testing and clinical features for diagnosis of COVID-19 facilitates management of SARS-CoV-2 outbreak (2020) J Med Virol, , https://doi.org/10.1002/jmv.25721; Benvenuto, D., Giovanetti, M., Ciccozzi, A., Spoto, S., Angeletti, S., Ciccozzi, M., The 2019-new coronavirus epidemic: Evidence for virus evolution (2020) J Med Virol, 92, pp. 455-459. , https://doi.org/10.1002/jmv.25688; Lu, R., Zhao, X., Li, J., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet, 395 (10224), pp. 565-574; Peiris, J., Lai, S., Poon, L., Coronavirus as a possible cause of severe acute respiratory syndrome (2003) The Lancet., 361 (9366), pp. 1319-1325; Li, W., Wong, S.K., Li, F., Animal origins of the severe acute respiratory syndrome coronavirus: insight from ACE2-S-protein interactions (2006) J Virol, 80 (9), pp. 4211-4219; Zaki, A.M., van Boheemen, S., Bestebroer, T.M., Osterhaus, A.D., Fouchier, R.A., Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia (2012) N Engl J Med, 367 (19), pp. 1814-1820; Siddell, S.G., Ziebuhr, J., Snijder, E.J., Coronaviruses, toroviruses, and arteriviruses (2005) Topley and Wilson's microbiology and microbial infections, , New York, NY, John Wiley & Sons; Cavanagh, D., The coronavirus surface glycoprotein (1995) The coronaviridae, pp. 73-113. , Germany, Springer; Kandeel, M., Al-Taher, A., Li, H., Schwingenschlogl, U., Al-Nazawi, M., Molecular dynamics of Middle East Respiratory Syndrome Coronavirus (MERS CoV) fusion heptad repeat trimers (2018) Comput Biol Chem, 75, pp. 205-212; Risco, C., Antón, I.M., Enjuanes, L., Carrascosa, J.L., The transmissible gastroenteritis coronavirus contains a spherical core shell consisting of M and N proteins (1996) J Virol, 70 (7), pp. 4773-4777; Ruch, T., Machamer, C., The coronavirus E protein: assembly and beyond (2012) Viruses, 4, pp. 363-382; Neuman, B.W., Kiss, G., Kunding, A.H., A structural analysis of M protein in coronavirus assembly and morphology (2011) J Struct Biol, 174 (1), pp. 11-22; Al Hajjar, S., Memish, Z.A., McIntoshc, K., Middle East respiratory syndrome coronavirus (MERS-CoV): a perpetual challenge (2013) Ann Saudi Med, 33 (5), pp. 427-436; Bahir, I., Fromer, M., Prat, Y., Linial, M., Viral adaptation to host: a proteome-based analysis of codon usage and amino acid preferences (2009) Mol Syst Biol, 5 (1), p. 311; van Hemert, F., van der Kuyl, A.C., Berkhout, B., Impact of the biased nucleotide composition of viral RNA genomes on RNA structure and codon usage (2016) J Gen Virol, 97 (10), pp. 2608-2619; Nakamura, Y., Gojobori, T., Ikemura, T., Codon usage tabulated from international DNA sequence databases: status for the year 2000 (2000) Nucleic Acids Res, 28 (1), p. 292; Chaney, J.L., Clark, P.L., Roles for synonymous codon usage in protein biogenesis (2015) Annu Rev Biophys, 44, pp. 143-166; Supek, F., The code of silence: Widespread associations between synonymous codon biases and gene function (2016) J Mol Evol, 82 (1), pp. 65-73; (2018) CLC Genomics Workbench 12.0 (QIAGEN, Aarhus, Denmark), , www.qiagenbioinformatics.com; Peden, J.F., (2000) Analysis of codon usage, , (Doctoral dissertation). University of Nottingham; Behura, S.K., Severson, D.W., Codon usage bias: causative factors, quantification methods and genome-wide patterns: with emphasis on insect genomes (2013) Biol Rev, 88 (1), pp. 49-61; Kandeel, M., Elshazly, K., El-Deeb, W., Fayez, M., Ghonim, I., Species specificity and host affinity rather than tissue tropism controls codon usage pattern in respiratory mycoplasmosis (2019) J Camel Pract Res, 26 (1), pp. 29-40; Gumpper, R.H., Li, W., Luo, M., Constraints of viral RNA synthesis on codon usage of negative-strand RNA virus (2019) J Virol, 93 (5), pp. e01775-e01718; Sheikh, A., Al-Taher, A., Al-Nazawi, M., Al-Mubarak, A.I., Kandeel, M., Analysis of preferred codon usage in the coronavirus N genes and their implications for genome evolution and vaccine design (2020) J Virol Methods, 277; Makhija, A., Kumar, S., Analysis of synonymous codon usage in spike protein gene of infectious bronchitis virus (2015) Can J Microbiol, 61 (12), pp. 983-989; Alnazawi, M., Altaher, A., Kandeel, M., Comparative genomic analysis MERS CoV isolated from humans and camels with special reference to virus encoded helicase (2017) Biol Pharm Bull, 40 (8), pp. 1289-1298; Gu, W., Zhou, T., Ma, J., Sun, X., Lu, Z., Analysis of synonymous codon usage in SARS Coronavirus and other viruses in the Nidovirales (2004) Virus Res, 101 (2), pp. 155-161; Jenkins, G.M., Holmes, E.C., The extent of codon usage bias in human RNA viruses and its evolutionary origin (2003) Virus Res, 92 (1), pp. 1-7; Zhou, T., Gu, W., Ma, J., Sun, X., Lu, Z., Analysis of synonymous codon usage in H5N1 virus and other influenza A viruses (2005) Biosystems, 81 (1), pp. 77-86; Kandeel, M., Altaher, A., Synonymous and biased codon usage by MERS CoV papain-like and 3CL-proteases (2017) Biol Pharm Bull, 40 (7), pp. 1086-1091; Wang, L., Xing, H., Yuan, Y., Genome-wide analysis of codon usage bias in four sequenced cotton species (2018) PLoS One, 13 (3); Nair, R.R., Raveendran, N.T., Dirisala, V.R., Mutational pressure drives evolution of synonymous codon usage in genetically distinct oenothera plastomes (2014) Iran J Biotechnol, 12 (4), pp. 58-72; Zhang, R., Zhang, L., Wang, W., Differences in codon usage bias between photosynthesis-related genes and genetic system-related genes of chloroplast genomes in cultivated and wild solanum species (2018) Int J Mol Sci, 19 (10), p. 3142","Kandeel, M.; Department of Biomedical Sciences, College of Veterinary Medicine, King Faisal UniversityEgypt; email: mkandeel@kfu.edu.sa",,John Wiley and Sons Inc.,1466615,,JMVID,32159237,English,J. Med. Virol.,Article,Article in Press,Open Access,Scopus,2-s2.0-85081579482,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Angeletti S., Benvenuto D., Bianchi M., Giovanetti M., Pascarella S., Ciccozzi M.",7003426796;57208408457;57215218665;55486066500;7004186897;8791594200;,COVID-2019: The role of the nsp2 and nsp3 in its pathogenesis,2020,Journal of Medical Virology,,,,,,,,10.1002/jmv.25719,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080113316&doi=10.1002%2fjmv.25719&partnerID=40&md5=a3900a167226ea3da40529c2337004ba,"Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome, Rome, Italy; Unit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome, Rome, Italy; Department of Biochemical Sciences ""A. Rossi Fanelli"", University of Rome “La Sapienza”, Rome, Italy; Flavivirus Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil","Angeletti, S., Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome, Rome, Italy; Benvenuto, D., Unit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome, Rome, Italy; Bianchi, M., Department of Biochemical Sciences ""A. Rossi Fanelli"", University of Rome “La Sapienza”, Rome, Italy; Giovanetti, M., Flavivirus Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil; Pascarella, S., Department of Biochemical Sciences ""A. Rossi Fanelli"", University of Rome “La Sapienza”, Rome, Italy; Ciccozzi, M., Unit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome, Rome, Italy","Last December 2019, a new virus, named novel Coronavirus (COVID-2019) causing many cases of severe pneumonia was reported in Wuhan, China. The virus knowledge is limited and especially about COVID-2019 pathogenesis. The Open Reading Frame 1ab (ORF1ab) of COVID-2019 has been analyzed to evidence the presence of mutation caused by selective pressure on the virus. For selective pressure analysis fast-unconstrained Bayesian approximation (FUBAR) was used. Homology modelling has been performed by SwissModel and HHPred servers. The presence of transmembrane helical segments in Coronavirus ORF1ab non structural protein 2 (nsp2) and nsp3 was tested by TMHMM, MEMSAT, and MEMPACK tools. Three-dimensional structures have been analyzed and displayed using PyMOL. FUBAR analysis revealed the presence of potential sites under positive selective pressure (P <.05). Position 723 in the COVID-2019 has a serine instead a glycine residue, while at aminoacidic position 1010 a proline instead an isoleucine. Significant (P <.05) pervasive negative selection in 2416 sites (55%) was found. The positive selective pressure could account for some clinical features of this virus compared with severe acute respiratory syndrome (SARS) and Bat SARS-like CoV. The stabilizing mutation falling in the endosome-associated-protein-like domain of the nsp2 protein could account for COVID-2019 high ability of contagious, while the destabilizing mutation in nsp3 proteins could suggest a potential mechanism differentiating COVID-2019 from SARS. These data could be helpful for further investigation aimed to identify potential therapeutic targets or vaccine strategy, especially in the actual moment when the epidemic is ongoing and the scientific community is trying to enrich knowledge about this new viral pathogen. © 2020 Wiley Periodicals, Inc.",epidemiology; infection; pandemics; pathogenesis; protein-protein interaction analysis; research and analysis methods,,"Hui, D.S., I Azhar, E., Madani, T.A., The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health—The latest 2019 novel coronavirus outbreak in Wuhan, China (2020) Int J Infect Dis, 91, pp. 264-266; Benvenuto, D., Giovannetti, M., Ciccozzi, A., Spoto, S., Angeletti, S., Ciccozzi, M., The 2019-new coronavirus epidemic: evidence for virus evolution (2020) J Med Virol, 92 (4), pp. 455-459. , https://doi.org/10.1002/jmv.25688; Liu, J., Zheng, X., Tong, Q., Overlapping and discrete aspects of the pathology and pathogenesis of the emerging human pathogenic coronaviruses SARS-CoV, MERS-CoV, and 2019-nCoV (2020) J Med Virol, , https://doi.org/10.1002/jmv.25709; Katoh, K., Rozewicki, J., Yamada, K.D., MAFFT online service: multiple sequence alignment, interactive sequence choice and visualization (2019) Brief Bioinform, 20 (4), pp. 1160-1166; Hall, T.A., BioEdit A user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT (1999) Nucleic Acids Symp Ser, 41, pp. 95-98; Murrell, B., Moola, S., Mabona, A., FUBAR: a fast, unconstrained bayesian approximation for inferring selection (2013) Mol Biol Evol, 30 (5), pp. 1196-1205; Murrell, B., Wertheim, J.O., Moola, S., Weighill, T., Scheffler, K., Kosakovsky Pond, S.L., Detecting individual sites subject to episodic diversifying selection (2012) PLoS Genet, 8 (7); Waterhouse, A., Bertoni, M., Bienert, S., SWISS-MODEL: homology modelling of protein structures and complexes (2018) Nucleic Acids Res, 46 (W1), pp. W296-W303; Zimmermann, L., Stephens, A., Nam, S.Z., A completely reimplemented MPI bioinformatics toolkit with a new HHpred server at its core (2018) J Mol Biol, 430 (15), pp. 2237-2243; Yang, J., Yan, R., Roy, A., Xu, D., Poisson, J., Zhang, Y., The I-TASSER suite: Protein structure and function prediction (2015) Nature Methods, 12 (1), pp. 7-8; Zhang, Y., Skolnick, J., Scoring function for automated assessment of protein structure template quality (2004) Proteins, 57 (4), pp. 702-710; Lovell, S.C., Structure validation by Calpha geometry: phi, psi, and Cbeta deviation (2003) Proteins, 50 (3), pp. 437-450; Moller, S., Croning, M.D.R., Apweiler, R., Evaluation of methods for the prediction of membrane spanning regions (2001) Bioinformatics, 17 (7), pp. 646-653; Nugent, T., Jones, D.T., Transmembrane protein topology prediction using support vector machines (2009) BMC Bioinformatics, 10, p. 159; Nugent, T., Ward, S., Jones, D.T., The MEMPACK alpha-helical transmembrane protein structure prediction server (2011) Bioinformatics, 27 (10), pp. 1438-1439; Schrödinger, L.L.C., (2015), The {PyMOL} Molecular Graphics System, Version 1.80 LLC, New York, NY; Saikatendu, K.S., Joseph, J.S., Subramanian, V., Structural basis of severe acute respiratory syndrome coronavirus ADP-ribose-1''-phosphate dephosphorylation by a conserved domain of nsP3 (2005) Structure, 13 (11), pp. 1665-1675; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395 (10223), pp. P497-P506. , https://doi.org/10.1016/S0140-6736(20)30183-5; Zhu, N., Zhang, D., Wang, W., China novel coronavirus investigating and research team. A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382, pp. 727-733. , https://doi.org/10.1056/NEJMoa2001017; Emerging understandings of 2019-nCoV (2020) Lancet, 395 (10221), p. 311; Giovanetti, M., Benvenuto, D., Angeletti, S., Ciccozzi, M., The first two cases of 2019-nCoV in Italy: where they come from? (2020) J Med Virol, , https://doi.org/10.1002/jmv.25699; Guarner, J., Three emerging coronaviruses in two decades (2020) Am J Clin Pathol, p. aqaa029. , https://doi.org/10.1093/ajcp/aqaa029","Angeletti, S.; Unit of Clinical Laboratory Science, University Campus Bio-Medico of RomeItaly; email: s.angeletti@unicampus.it",,John Wiley and Sons Inc.,1466615,,JMVID,32083328,English,J. Med. Virol.,Article,Article in Press,Open Access,Scopus,2-s2.0-85080113316,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Checovich M.M., Barlow S., Shult P., Reisdorf E., Temte J.L.",6506678983;22984114400;6701523487;8536775600;7004084974;,"Evaluation of Viruses Associated With Acute Respiratory Infections in Long-Term Care Facilities Using a Novel Method: Wisconsin, 2016‒2019",2020,Journal of the American Medical Directors Association,21,1,,29,33,,1,10.1016/j.jamda.2019.09.003,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85073755573&doi=10.1016%2fj.jamda.2019.09.003&partnerID=40&md5=59f836d6ecf8444284baa9d0ff8243c2,"Department of Family Medicine and Community Health, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States; Wisconsin State Laboratory of Hygiene, Madison, WI, United States","Checovich, M.M., Department of Family Medicine and Community Health, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States; Barlow, S., Department of Family Medicine and Community Health, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States; Shult, P., Wisconsin State Laboratory of Hygiene, Madison, WI, United States; Reisdorf, E., Wisconsin State Laboratory of Hygiene, Madison, WI, United States; Temte, J.L., Department of Family Medicine and Community Health, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States","Residents of long-term care facilities (LCTFs) have high morbidity and mortality associated with acute respiratory infections (ARIs). Limited information exists on the virology of ARI in LTCFs, where virological testing is reactive. We report on findings of a surveillance feasibility substudy from a larger prospective trial of introducing rapid influenza diagnostic testing (RIDT) at 10 Wisconsin LTCFs. Any resident with symptoms consistent with ARI had a nasal swab specimen collected for RIDT by staff. Following RIDT, the residual swab was placed into viral transport medium and tested for influenza using Reverse transcription polymerase chain reaction, and for 20 pathogens using a multiplex polymerase chain reaction respiratory pathogen panel. Numbers of viruses in each of 7 categories (influenza A, influenza B, coronaviruses, human metapneumovirus, parainfluenza, respiratory syncytial virus, and rhinovirus/enterovirus) across the 3 years were compared using χ2. Totals of 160, 215, and 122 specimens were collected during 2016‒2017, 2017‒2018, and 2018‒2019, respectively. Respiratory pathogen panel identified viruses in 54.8% of tested specimens. Influenza A (19.2%), influenza B (12.6%), respiratory syncytial virus (15.9%), and human metapneumovirus (20.9%) accounted for 69% of all detections, whereas coronaviruses (17.2%), rhinovirus/enterovirus (10.5%) and parainfluenza (3.8%) were less common. The distribution of viruses varied significantly across the 3 years (χ2 = 71.663; df = 12; P <.001). Surveillance in LTCFs using nasal swabs collected for RIDT is highly feasible and yields high virus identification rates. Significant differences in virus composition occurred across the 3 study years. Simple approaches to surveillance may provide a more comprehensive assessment of respiratory viruses in LTCF settings. © 2019 AMDA – The Society for Post-Acute and Long-Term Care Medicine",acute respiratory infection; influenza; Long-term care; rapid influenza diagnostic testing,adult; aged; Article; Coronavirinae; female; human; Human metapneumovirus; Human respiratory syncytial virus; influenza; Influenza A virus; Influenza B virus; long term care; male; multiplex polymerase chain reaction; nose smear; Paramyxovirinae; prospective study; resident; respiratory tract infection; reverse transcription polymerase chain reaction; Rhinovirus; very elderly; virus detection; Wisconsin,"Fowlkes, A., Dasgupta, S., Chao, E., Estimating influenza incidence and rates of influenza-like illness in the outpatient setting (2013) Influenza Other Respir Viruses, 7, pp. 694-700; Fluview, C.D.C., 2017-2018 influenza season week 20 ending May 19, 2018 https://www.cdc.gov/flu/weekly/weeklyarchives2017-2018/Week20.htm, Available at: (Accessed 20 January 2019); Wisconsin Division of Public Health Respiratory Virus Surveillance Report Week Ending May 19, 2018 https://www.dhs.wisconsin.gov/influenza/weekly-influenza-report.pdf, Available at: (Accessed 19 May 2018); Demographics of Aging in Wisconsin https://www.dhs.wisconsin.gov/aging/demographics.htm, Available at: (Accessed 7 December 2018); Hartmen, L., Zhu, Y., Edwards, K.M., Underdiagnosis of influenza virus infection in hospitalized older adults (2018) J Am Geriatr Soc, 66, pp. 467-472; Gravenstein, S., Davidson, H.E., Current strategies for management of influenza in the elderly population (2002) Clin Infect Dis, 35, pp. 729-737; Millership, S., Cummins, A., Oseltamivir in influenza outbreaks in care homes: Challenges and benefits of use in the real world (2015) J Hosp Infect, 90, pp. 299-303; Affifi, R.M., Omar, S.R., El Raggal, A.A., A novel influenza A (H1N1) outbreak experience among residents of a long term-care facility in Saudi Arabia during 2010 seasonal flu circulation (2012) Infect Dis Re, 13, p. e23; Lemaitre, M., Meret, T., Rothan-Tondeur, M., Effect of influenza vaccination of nursing home staff on mortality of residents: A cluster-randomized trial (2009) J Am Geriatr Soc, 57, pp. 1580-1586; Mahmud, S.M., Thompson, L.H., Nowicki, D.L., Plourde, P.J., Outbreaks of influenza-like illness in long-term care facilities in Winnipeg, Canada (2013) Influenza Other Respir Viruses, 7, pp. 1055-1061; Win, M.K., Chow, A., Chen, M., Influenza B outbreak among influenza-vaccinated welfare home residents in Singapore (2010) Ann Acad Med Singapore, 39, pp. 448-452; Dowson, L., Marshall, C., Buising, K., Optimizing treatment of respiratory tract infections in nursing homes: Nurse-initiated polymerase chain reaction testing (2019) Am J Infect Control, 47, pp. 911-915; Statutes. Chapter 252. Communicable diseases https://docs.legis.wisconsin.gov/statutes/statutes/252/05, Available at: (Accessed 22 August 2019); Sofia influenza A+B http://www.quidel.com/fluorescence/assays/influenza-a-b.php, Available at: (Accessed 20 January 2019); CDC human influenza virus real-Time RT-PCR diagnostic panel (CDC Flu rRT-PCR Dx Panel). LB-067 Rev 1 CDC/OID/NCIRD/Influenza Division. Effective: June 13, 2014 https://www.researchgate.net/publication/321900045_S1_File/data/5a386b9c458515919e71f7d8/pone0186735s002.pdf, Available at: Accessed June 11, 2019; NxTAG® Respiratory Pathogen Panel. Accessed 6/07/2019 https://www.luminexcorp.com/nxtag-respiratory-pathogen-panel/, Available at: (Accessed 7 June 2019); Masse, S., Capai, L., Falchi, A., Epidemiology of respiratory pathogens among elderly nursing home residents with acute respiratory infections in Corsica, France, 2013-2017 (2017) Biomed Res Int, 2017, p. 1423718; Uršič, T., Miksić, N.G., Lusa, L., Viral respiratory infections in a nursing home: A six-month prospective study (2016) BMC Infect Dis, 16, p. 637; Uyeki, T.M., Bernstein, H.H., Bradley, J.S., Clinical practice guidelines by the Infectious Diseases Society of America: 2018 Update on diagnosis, treatment, chemoprophylaxis, and institutional outbreak management of seasonal influenza (2019) Clin Infectious Dis, 68, pp. e1-e47; Chasqueira, M.J., Paixão, P., Rodrigues, M.L., Respiratory infections in elderly people: Viral role in a resident population of elderly care centers in Lisbon, winter 2013-2014 (2018) Int J Infect Dis, 69, pp. 1-7; Kodama, F., Nace, D.A., Jump, R.L.P., Respiratory syncytial virus and other noninfluenza respiratory viruses in older adults (2017) Infect Dis Clin North Am, 31, pp. 767-790; Outbreaks of human metapneumovirus in two skilled nursing facilities -West Virginia and Idaho, 2011–2012 (2013) Morb Mortal Wkly Rep, 22 (62), pp. 909-913","Checovich, M.M.; Department of Family Medicine and Community Health, University of Wisconsin School of Medicine and Public Health, 1100 Delaplaine Court, United States; email: mary.checovich@fammed.wisc.edu",,Elsevier Inc.,15258610,,JAMDC,31636034,English,J. Am. Med. Dir. Assoc.,Article,Final,Open Access,Scopus,2-s2.0-85073755573,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Tilocca B., Soggiu A., Musella V., Britti D., Sanguinetti M., Urbani A., Roncada P.",56986413900;25947913200;8088048400;6701857657;57213310316;55198663000;55574122415;,Molecular basis of COVID-19 relationships in different species: a one health perspective,2020,Microbes and Infection,,,,,,,,10.1016/j.micinf.2020.03.002,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082113796&doi=10.1016%2fj.micinf.2020.03.002&partnerID=40&md5=5910320621f4b1e6b7c697fc65b488eb,"Department of Health Science, University “Magna Græcia” of Catanzaro, Viale Europa, Catanzaro, 88100, Italy; Department of Veterinary Sciences, University of Milano, Via Celoria n10, Milano, 20133, Italy; Department of Basic Biotechnological Sciences, Intensivological and Perioperative Clinics, Università Cattolica del Sacro Cuore, Largo S. Vito n1, Rome, 00168, Italy; Dipartimento Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario Gemelli IRCCS, Largo S. Vito n8, Rome, 00168, Italy","Tilocca, B., Department of Health Science, University “Magna Græcia” of Catanzaro, Viale Europa, Catanzaro, 88100, Italy; Soggiu, A., Department of Veterinary Sciences, University of Milano, Via Celoria n10, Milano, 20133, Italy; Musella, V., Department of Health Science, University “Magna Græcia” of Catanzaro, Viale Europa, Catanzaro, 88100, Italy; Britti, D., Department of Health Science, University “Magna Græcia” of Catanzaro, Viale Europa, Catanzaro, 88100, Italy; Sanguinetti, M., Department of Basic Biotechnological Sciences, Intensivological and Perioperative Clinics, Università Cattolica del Sacro Cuore, Largo S. Vito n1, Rome, 00168, Italy, Dipartimento Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario Gemelli IRCCS, Largo S. Vito n8, Rome, 00168, Italy; Urbani, A., Department of Basic Biotechnological Sciences, Intensivological and Perioperative Clinics, Università Cattolica del Sacro Cuore, Largo S. Vito n1, Rome, 00168, Italy, Dipartimento Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario Gemelli IRCCS, Largo S. Vito n8, Rome, 00168, Italy; Roncada, P., Department of Health Science, University “Magna Græcia” of Catanzaro, Viale Europa, Catanzaro, 88100, Italy","Outside the Hubei province, China, the mild form of infection and the progressive recover of the COVID-19 patients suggest the intervention of “unconventional” biological mechanisms worthy of attention. Based on the high-homology between the Spike protein epitopes of taxonomically-related coronaviruses, we hypothesized that past contact with infected dogs shield humans against the circulating SARS-CoV-2. Elseways, the recurrent virus exposure over a short time-lapse might result in the Antibody Dependent Enhancement, triggering the violent immune reaction responsible for the severe clinical outcomes observed in the Hubei province. Nevertheless, further experimental studies are desired for a confidential evaluation of the postulated hypotheses. © 2020 Institut Pasteur",Canine respiratory coronavirus; Coronavirus; COVID-19; Immunization; One health; SARS-CoV-2,,"Lu, R., Zhao, X., Li, J., Niu, P., Yang, B., Wu, H., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet, 395, pp. 565-574; Jalava, K., First respiratory transmitted food borne outbreak? (2020) Int J Hyg Environ Health, 226, p. 113490; Chen, Y., Liu, Q., Guo, D., Emerging coronaviruses: genome structure, replication, and pathogenesis (2020) J Med Virol, 92, pp. 418-423; Tetro, J.A., Is COVID-19 receiving ADE from other coronaviruses? (2020) Microb Infect, , online ahead of print; Ji, W., Wang, W., Zhao, X., Zai, J., Li, X., Homologous recombination within the spike glycoprotein of the newly identified coronavirus may boost cross-species transmission from snake to human (2020) J Med Virol, 92, pp. 433-440; Cheung, C.Y., Poon, L.L.M., Ng, I.H.Y., Luk, W., Sia, S.-F., Wu, M.H.S., Cytokine responses in severe acute respiratory syndrome coronavirus-infected macrophages in vitro: possible relevance to pathogenesis (2005) J Virol, 79, pp. 7819-7826; Donnelly, C.A., Fisher, M.C., Fraser, C., Ghani, A.C., Riley, S., Ferguson, N.M., Epidemiological and genetic analysis of severe acute respiratory syndrome (2004) Lancet Infect Dis, 4, pp. 672-683; Li, R., Qiao, S., Zhang, G., Analysis of angiotensin-converting enzyme 2 (ACE2) from different species sheds some light on cross-species receptor usage of a novel coronavirus 2019-nCoV (2020) J Infect, , online ahead of print; Hua, R., Zhou, Y., Wang, Y., Hua, Y., Tong, G., Identification of two antigenic epitopes on SARS-CoV spike protein (2004) Biochem Biophys Res Commun, 319, pp. 929-935; Decaro, N., Desario, C., Elia, G., Mari, V., Lucente, M.S., Cordioli, P., Serological and molecular evidence that canine respiratory coronavirus is circulating in Italy (2007) Vet Microbiol, 121, pp. 225-230; Tennant, B.J., Gaskell, R.M., Jones, R.C., Gaskell, C.J., Studies on the epizootiology of canine coronavirus (1993) Vet Rec, 132, pp. 7-11; Szczepanski, A., Owczarek, K., Milewska, A., Baster, Z., Rajfur, Z., Mitchell, J.A., Canine respiratory coronavirus employs caveolin-1-mediated pathway for internalization to HRT-18G cells (2018) Vet Res, 49, p. 55; Szczepanski, A., Owczarek, K., Bzowska, M., Gula, K., Drebot, I., Ochman, M., Canine respiratory coronavirus, bovine coronavirus, and human coronavirus OC43: receptors and attachment factors (2019) Viruses, 11, p. 328; Yang, Z.Y., Werner, H.C., Kong, W.P., Leung, K., Traggiai, E., Lanzavecchia, A., Evasion of antibody neutralization in emerging severe acute respiratory syndrome coronaviruses (2005) Proc Natl Acad Sci U S A, 102, pp. 797-801; Ho, M.S., Chen, W.J., Chen, H.Y., Lin, S.F., Wang, W.C., Di, J., Neutralizing antibody response and SARS severity (2005) Emerg Infect Dis, 11, pp. 1730-1737; Yip, M.S., Leung, N.H.L., Cheung, C.Y., Li, P.H., Lee, H.H.Y., Daëron, M., Antibody-dependent infection of human macrophages by severe acute respiratory syndrome coronavirus (2014) Virol J, 11, p. 82; Jaume, M., Yip, M.S., Cheung, C.Y., Leung, H.L., Li, P.H., Kien, F., Anti-severe acute respiratory syndrome coronavirus spike antibodies trigger infection of human immune cells via a pH- and cysteine protease-independent Fc R pathway (2011) J Virol, 85, pp. 10582-10597; Wang, S.F., Tseng, S.P., Yen, C.H., Yang, J.Y., Tsao, C.H., Shen, C.W., Antibody-dependent SARS coronavirus infection is mediated by antibodies against spike proteins (2014) Biochem Biophys Res Commun, 451, pp. 208-214; Bai, Y., Yao, L., Wei, T., Tian, F., Jin, D.-Y., Chen, L., Presumed asymptomatic carrier transmission of COVID-19 (2020) JAMA, , online ahead of print; Buonavoglia, C., Decaro, N., Martella, V., Elia, G., Campolo, M., Desario, C., Canine coronavirus highly pathogenic for dogs (2006) Emerg Infect Dis, 12, pp. 492-494","Roncada, P.; Department of Health Science, University “Magna Græcia” of Catanzaro, Viale Europa, Italy; email: roncada@unicz.it",,Elsevier Masson SAS,12864579,,MCINF,32194253,English,Microbes Infect.,Article,Article in Press,Open Access,Scopus,2-s2.0-85082113796,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Deng L., Li C., Zeng Q., Liu X., Li X., Zhang H., Hong Z., Xia J.",57215934638;56763124900;57215933183;57215937053;57199734942;57215933164;57215854014;57215852215;,Arbidol combined with LPV/r versus LPV/r alone against Corona Virus Disease 2019: A retrospective cohort study,2020,Journal of Infection,,,,,,,,10.1016/j.jinf.2020.03.002,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082430676&doi=10.1016%2fj.jinf.2020.03.002&partnerID=40&md5=445a49c15a3e6c4f3787444ae08c6c5f,"Department of Infectious Diseases, the Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Road, Zhuhai, Guangdong Province 519000, China; Cancer Center, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, China","Deng, L., Department of Infectious Diseases, the Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Road, Zhuhai, Guangdong Province 519000, China; Li, C., Department of Infectious Diseases, the Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Road, Zhuhai, Guangdong Province 519000, China; Zeng, Q., Cancer Center, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, China; Liu, X., Department of Infectious Diseases, the Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Road, Zhuhai, Guangdong Province 519000, China; Li, X., Department of Infectious Diseases, the Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Road, Zhuhai, Guangdong Province 519000, China; Zhang, H., Department of Infectious Diseases, the Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Road, Zhuhai, Guangdong Province 519000, China; Hong, Z., Department of Infectious Diseases, the Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Road, Zhuhai, Guangdong Province 519000, China; Xia, J., Department of Infectious Diseases, the Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Road, Zhuhai, Guangdong Province 519000, China","Background: Corona Virus Disease 2019 (COVID-19) due to the 2019 novel coronavirus (SARS-CoV-2) emerged in Wuhan city and rapidly spread throughout China. We aimed to compare arbidol and lopinavir/ritonavir(LPV/r) treatment for patients with COVID-19 with LPV/r only. Methods: In this retrospective cohort study, we included adults (age≥18years) with laboratory-confirmed COVID-19 without Invasive ventilation, diagnosed between Jan 17, 2020, and Feb 13, 2020. Patients, diagnosed after Jan 17, 2020, were given oral arbidol and LPV/r in the combination group and oral LPV/r only in the monotherapy group for 5–21 days. The primary endpoint was a negative conversion rate of coronavirus from the date of COVID-19 diagnosis(day7, day14), and assessed whether the pneumonia was progressing or improving by chest CT (day7). Results: We analyzed 16 patients who received oral arbidol and LPV/r in the combination group and 17 who oral LPV/r only in the monotherapy group, and both initiated after diagnosis. Baseline clinical, laboratory, and chest CT characteristics were similar between groups. The SARS-CoV-2 could not be detected for 12(75%) of 16 patients’ nasopharyngeal specimens in the combination group after seven days, compared with 6 (35%) of 17 in the monotherapy group (p < 0·05). After 14 days, 15 (94%) of 16 and 9 (52·9%) of 17, respectively, SARS-CoV-2 could not be detected (p < 0·05). The chest CT scans were improving for 11(69%) of 16 patients in the combination group after seven days, compared with 5(29%) of 17 in the monotherapy group (p < 0·05). Conclusion: In patients with COVID-19, the apparent favorable clinical response with arbidol and LPV/r supports further LPV/r only. © 2020",Antiviral intervention; Arbidol; Combination therapy; Corona Virus Disease 2019; Lopinavir/ritonavir,,"Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Clinical characteristics of 138 hospitalized patients with 2019 Novel Coronavirus-infected pneumonia in Wuhan, China (2020) JAMA, , 2020-02-07. [Epub ahead of print]; Zhang, J.J., Dong, X., Cao, Y.Y., Yuan, Y.D., Yang, Y.B., Yan, Y.Q., Clinical characteristics of 140 patients infected by SARS-CoV-2 in Wuhan, China (2020) Allergy, , 2020-02-19. [Epub ahead of print]; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395 (10223), pp. 497-506. , 2020-02-15; Lu, R., Zhao, X., Li, J., Niu, P., Yang, B., Wu, H., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet, 395 (10224), pp. 565-574. , 2020-02-22; Chan, J.F.W., Yuan, S., Kok, K.H., To, K.K.W., Chu, H., Yang, J., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, 395 (10223), pp. 514-523. , 2020-02-15; Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395 (10223), pp. 507-513. , 2020-02-15; Chu, C.M., Cheng, V.C.C., Hung, I.F.N., Wong, M.M.L., Chan, K.H., Chan, K.S., Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings (2004) Thorax, 59 (3), pp. 252-256. , 2004-03-01; Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected: clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected: interim guidance; Chung, M., Bernheim, A., Mei, X., Zhang, N., Huang, M., Zeng, X., CT imaging features of 2019 Novel Coronavirus (2019-nCoV) (2020) Radiology, , 2020-02-04:200230; Metlay, J.P., Waterer, G.W., Long, A.C., Anzueto, A., Brozek, J., Crothers, K., Diagnosis and treatment of adults with community-acquired pneumonia. an official clinical practice guideline of the American Thoracic Society and Infectious Diseases Society of America (2019) Am J Respir Crit Care Med, 200 (7), pp. e45-e67. , 2019-10-01; Mo, Y., Fisher, D., A review of treatment modalities for Middle East respiratory syndrome (2016) J Antimicrob Chemother, 71 (12), pp. 3340-3350. , 2016-12-01; Khamitov, R.A., Loginova, S., Shchukina, V.N., Borisevich, S.V., Maksimov, V.A., Shuster, A.M., [Antiviral activity of arbidol and its derivatives against the pathogen of severe acute respiratory syndrome in the cell cultures] (2008) Vopr Virusol, 53 (4), pp. 9-13. , 2008-07-01; Barnard, D.L., Kumaki, Y., Recent developments in anti-severe acute respiratory syndrome coronavirus chemotherapy (2011) Fut Virol, 6 (5), pp. 615-631. , 2011-05-01; Peiris, J.S.M., Chu, C.M., Cheng, V.C.C., Chan, K.S., Hung, I.F.N., Poon, L.L., Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study (2003) Lancet, 361 (9371), pp. 1767-1772. , 2003-05-24; Munster, V.J., Koopmans, M., van Doremalen, N., van Riel, D., de Wit, E., A Novel Coronavirus emerging in China - key questions for impact assessment (2020) New Engl J Med, 382 (8), pp. 692-694. , 2020-02-20; Zhou, P., Yang, X.L., Wang, X.G., Hu, B., Zhang, L., Zhang, W., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature, , 2020-02-03; Harmer, D., Gilbert, M., Borman, R., Clark, K.L., Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme (2002) FEBS Lett, 532 (1-2), pp. 107-110. , 2002-12-04; Boriskin, Y.S., Leneva, I.A., Pecheur, E.I., Polyak, S.J., Arbidol: a broad-spectrum antiviral compound that blocks viral fusion (2008) Curr Med Chem, 15 (10), pp. 997-1005. , 2008-01-20; Cvetkovic, R.S., Goa, K.L., Lopinavir/ritonavir: a review of its use in the management of HIV infection (2003) Drugs, 63 (8), pp. 769-802. , 2003-01-20; Blaising, J., Polyak, S.J., Pecheur, E.I., Arbidol as a broad-spectrum antiviral: an update (2014) Antiviral Res, 107, pp. 84-94. , 2014-07-01; Molina, J.M., Andrade-Villanueva, J., Echevarria, J., Chetchotisakd, P., Corral, J., David, N., Once-daily atazanavir/ritonavir versus twice-daily lopinavir/ritonavir, each in combination with tenofovir and emtricitabine, for management of antiretroviral-naive HIV-1-infected patients: 48 week efficacy and safety results of the Castle study (2008) Lancet, 372 (9639), pp. 646-655. , 2008-08-23; Stockman, L.J., Bellamy, R., Garner, P., SARS: systematic review of treatment effects (2006) Plos Med, 3 (9), p. e343. , 2006-09-01; Arabi, Y.M., Mandourah, Y., Al-Hameed, F., Sindi, A.A., Almekhlafi, G.A., Hussein, M.A., Corticosteroid therapy for critically ill patients with Middle East respiratory syndrome (2018) Am J Respir Crit Care Med, 197 (6), pp. 757-767. , 2018-03-15; Public Health England, International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC). Clinical decision making tool for treatment of MERS-CoV; Xu, Z., Shi, L., Wang, Y., Zhang, J., Huang, L., Zhang, C., Pathological findings of COVID-19 associated with acute respiratory distress syndrome (2020) Lancet Respir Med, , 2020-02-18; Omrani, A.S., Saad, M.M., Baig, K., Bahloul, A., Abdul-Matin, M., Alaidaroos, A.Y., Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study (2014) Lancet Infect Dis, 14 (11), pp. 1090-1095. , 2014-11-01","Hong, Z.; Department of Infectious Diseases, the Fifth Affiliated Hospital, Sun Yat-sen University, 52 East Meihua Road, China; email: hongzhs@mail.sysu.edu.cn",,W.B. Saunders Ltd,1634453,,JINFD,32171872,English,J. Infect.,Review,Article in Press,Open Access,Scopus,2-s2.0-85082430676,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhang J.-J., Dong X., Cao Y.-Y., Yuan Y.-D., Yang Y.-B., Yan Y.-Q., Akdis C.A., Gao Y.-D.",57207737644;57215217471;57215215036;15133649300;57215218197;57215212284;57204593994;35798243100;,"Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China",2020,Allergy: European Journal of Allergy and Clinical Immunology,,,,,,,11,10.1111/all.14238,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080137864&doi=10.1111%2fall.14238&partnerID=40&md5=ea0367886c61eaead16de34a6e4f1ec5,"Department of Allergology, Zhongnan Hospital of Wuhan University, Wuhan, China; Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China; Department of Respiratory and Critical Care Medicine, Second Hospital of Hebei Medical University, Shijiazhuang, China; Department of Respiratory and Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China; Department of Infectious Disease, No. 7 Hospital of Wuhan, Wuhan, China; Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland","Zhang, J.-J., Department of Allergology, Zhongnan Hospital of Wuhan University, Wuhan, China; Dong, X., Department of Allergology, Zhongnan Hospital of Wuhan University, Wuhan, China; Cao, Y.-Y., Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China; Yuan, Y.-D., Department of Respiratory and Critical Care Medicine, Second Hospital of Hebei Medical University, Shijiazhuang, China; Yang, Y.-B., Department of Respiratory and Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China; Yan, Y.-Q., Department of Infectious Disease, No. 7 Hospital of Wuhan, Wuhan, China; Akdis, C.A., Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland; Gao, Y.-D., Department of Allergology, Zhongnan Hospital of Wuhan University, Wuhan, China","Background: Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been widely spread. We aim to investigate the clinical characteristic and allergy status of patients infected with SARS-CoV-2. Methods: Electronic medical records including demographics, clinical manifestation, comorbidities, laboratory data, and radiological materials of 140 hospitalized COVID-19 patients, with confirmed result of SARS-CoV-2 viral infection, were extracted and analyzed. Results: An approximately 1:1 ratio of male (50.7%) and female COVID-19 patients was found, with an overall median age of 57.0 years. All patients were community-acquired cases. Fever (91.7%), cough (75.0%), fatigue (75.0%), and gastrointestinal symptoms (39.6%) were the most common clinical manifestations, whereas hypertension (30.0%) and diabetes mellitus (12.1%) were the most common comorbidities. Drug hypersensitivity (11.4%) and urticaria (1.4%) were self-reported by several patients. Asthma or other allergic diseases were not reported by any of the patients. Chronic obstructive pulmonary disease (COPD, 1.4%) patients and current smokers (1.4%) were rare. Bilateral ground-glass or patchy opacity (89.6%) was the most common sign of radiological finding. Lymphopenia (75.4%) and eosinopenia (52.9%) were observed in most patients. Blood eosinophil counts correlate positively with lymphocyte counts in severe (r =.486, P <.001) and nonsevere (r =.469, P <.001) patients after hospital admission. Significantly higher levels of D-dimer, C-reactive protein, and procalcitonin were associated with severe patients compared to nonsevere patients (all P <.001). Conclusion: Detailed clinical investigation of 140 hospitalized COVID-19 cases suggests eosinopenia together with lymphopenia may be a potential indicator for diagnosis. Allergic diseases, asthma, and COPD are not risk factors for SARS-CoV-2 infection. Older age, high number of comorbidities, and more prominent laboratory abnormalities were associated with severe patients. © 2020 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.",allergy; COVID-19; eosinophil; risk factor; SARS-CoV-2,,"Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395 (10223), pp. 507-513; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395 (10223), pp. 497-506; Wang, D., Hu, B., Hu, C., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) JAMA, , https://doi.org/10.1001/jama.2020.1585, [Epub ahead of print]; Guan, W., Ni, Z., Hu, Y., Clinical characteristics of 2019 novel coronavirus infection in China, , medRxiv 20202020.02.06.20020974; Coronavirus disease (COVID-2019) situation reports, , https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports, Accessed February 19, 2020; Tan, W.J., Zhao, X., Ma, X.J., A novel coronavirus genome identified in a cluster of pneumonia cases—Wuhan, China 2019–2020 (2020) China CDC Weekly, 2, pp. 61-62; Rambaut, A., Preliminary Phylogenetic Analysis of 11 nCoV2019 Genomes, 2020–01-19, , http://virological.org/t/preliminary-phylogenetic-analysis-of-11-ncov2019-genomes-2020-01-19/329, Accessed February 12, 2020; Gralinski, L.E., Menachery, V.D., Return of the Coronavirus: 2019-nCoV (2020) Viruses, 12 (2), p. 135; Chan, J.F., Yuan, S., Kok, K.H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, 395 (10223), pp. 514-523; Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med, , https://doi.org/10.1056/NEJMoa2001316, [Epub ahead of print]; Jackson, D.J., Evans, M.D., Gangnon, R.E., Evidence for a causal relationship between allergic sensitization and rhinovirus wheezing in early life (2012) Am J Respir Crit Care Med, 185, pp. 281-285; Rubner, F.J., Jackson, D.J., Evans, M.D., Early life rhinovirus wheezing, allergic sensitization, and asthma risk at adolescence (2017) J Allergy Clin Immunol, 139, pp. 501-507; 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Leino, A., Lukkarinen, M., Turunen, R., Pulmonary function and bronchial reactivity 4 years after the first virus-induced wheezing (2019) Allergy, 74, pp. 518-526; Svensson, A., Nordström, I., Rudin, A., Bergström, T., Eriksson, K., Enveloped virus but not bacteria block IL-13 responses in human cord blood T cells in vitro (2012) Scand J Immunol, 75, pp. 409-418; Wang, C., Xu, J., Yang, L., Prevalence and risk factors of chronic obstructive pulmonary disease in China (the China Pulmonary Health [CPH] study): a national cross-sectional study (2018) Lancet, 391, pp. 1706-1717; Kurai, D., Saraya, T., Ishii, H., Takizawa, H., Virus-induced exacerbations in asthma and COPD (2013) Front Microbiol, 4, p. 293; Hu, S.S., Gao, R.L., Liu, L.S., Summary of the 2018 report on cardiovascular diseases in China (2019) Chin Circ J, 34, pp. 209-220; Liu, M., Liu, S.W., Wang, L.J., Burden of diabetes, hyperglycaemia in China from to 2016: Findings from the 1990 to 2016, global burden of disease study (2019) Diabetes Metab, 45, pp. 286-293; Booth, C.M., Matukas, L.M., Tomlinson, G.A., Clinical features and short-term outcomes of 144 patients with SARS in the greater Toronto area (2003) JAMA, 289, pp. 2801-2809; Huang, K., Yang, T., Xu, J., Prevalence, risk factors, and management of asthma in China: a national cross-sectional study (2019) Lancet, 394, pp. 407-418; Wang, X.D., Zheng, M., Lou, H.F., An increased prevalence of self-reported allergic rhinitis in major Chinese cities from 2005 to 2011 (2016) Allergy, 71, pp. 1170-1180; Papadopoulos, N.G., Christodoulou, I., Rohde, G., Viruses and bacteria in acute asthma exacerbations–a GA2LEN-DARE systematic review (2011) Allergy, 66, pp. 458-468; Greenberg, S.B., Update on human rhinovirus and coronavirus infections (2016) Semin Respir Crit Care Med, 37, pp. 555-571; Zheng, X.Y., Xu, Y.J., Guan, W.J., Lin, L.F., Regional, age and respiratory-secretion-specific prevalence of respiratory viruses associated with asthma exacerbation: a literature review (2018) Arch Virol, 163, pp. 845-853; Han, M., Rajput, C., Ishikawa, T., Jarman, C.R., Lee, J., Small, H.M.B., Animal models of respiratory viral infection related to asthma (2018) Viruses, 10 (12), p. 682; Bønnelykke, K., Vissing, N.H., Sevelsted, A., Johnston, S.L., Bisgaard, H., Association between respiratory infections in early life and later asthma is independent of virus type (2015) J Allergy Clin Immunol, 136, pp. 81-86; Erdem, S.B., Can, D., Girit, S., Does atopy affect the course of viral pneumonia (2018) Allergol Immunopathol, 46, pp. 119-126; WHO report on the global tobacco epidemic, 2019 (Country Profile: China), , https://www.who.int/tobacco/surveillance/policy/country_profile/chn.pdf?ua=1, Accessed February 17, 2020; Seys, L., Widagdo, W., Verhamme, F.M., DPP4, the middle east respiratory syndrome coronavirus receptor, is upregulated in lungs of smokers and chronic obstructive pulmonary disease patients (2018) Clin Infect Dis, 66, pp. 45-53; Kuba, K., Imai, Y., Rao, S., A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury (2005) Nat Med, 11, pp. 875-879; Kuba, K., Imai, Y., Rao, S., Jiang, C., Penninger, J.M., Lessons from SARS: control of acute lung failure by the SARS receptor ACE2 (2006) J Mol Med, 84, pp. 814-820; Kuba, K., Imai, Y., Penninger, J.M., Angiotensin-converting enzyme 2 in lung diseases (2006) Curr Opin Pharmacol, 6, pp. 271-276; Xu, X., Chen, P., Wang, J., Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission (2020) Sci China Life Sci, , https://doi.org/10.1007/s11427-020-1637-5, [Epub ahead of print]","Gao, Y.-D.; Department of Allergology, Zhongnan Hospital of Wuhan UniversityChina; email: gaoyadong@whu.edu.cn",,Blackwell Publishing Ltd,1054538,,LLRGD,32077115,English,Allergy Eur. J. Allergy Clin. Immunol.,Article,Article in Press,Open Access,Scopus,2-s2.0-85080137864,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Gao J., Tian Z., Yang X.",56181235900;57183489200;57183220300;,Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies,2020,BioScience Trends,14,1,1047,,,,14,10.5582/BST.2020.01047,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080879659&doi=10.5582%2fBST.2020.01047&partnerID=40&md5=ec444c73d039c3dd05a53ca69e47b221,"Department of Pharmacology, School of Pharmacy, Qingdao University, Qingdao, China; Department of Pharmacy, Qingdao Municipal Hospital, Qingdao, China","Gao, J., Department of Pharmacology, School of Pharmacy, Qingdao University, Qingdao, China; Tian, Z., Department of Pharmacy, Qingdao Municipal Hospital, Qingdao, China; Yang, X., Department of Pharmacy, Qingdao Municipal Hospital, Qingdao, China","The coronavirus disease 2019 (COVID-19) virus is spreading rapidly, and scientists are endeavoring to discover drugs for its efficacious treatment in China. Chloroquine phosphate, an old drug for treatment of malaria, is shown to have apparent efficacy and acceptable safety against COVID-19 associated pneumonia in multicenter clinical trials conducted in China. The drug is recommended to be included in the next version of the Guidelines for the Prevention, Diagnosis, and Treatment of Pneumonia Caused by COVID-19 issued by the National Health Commission of the People's Republic of China for treatment of COVID-19 infection in larger populations in the future. © 2020 International Advancement Center for Medicine and Health Research Co., Ltd.",2019-nCoV; Chloroquine; COVID-19; Pneumonia; SARS-CoV-2,"chloroquine; COVID-19; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; China; clinical trial (topic); Coronavirus infection; drug repositioning; human; multicenter study (topic); virus pneumonia; Betacoronavirus; China; Chloroquine; Clinical Trials as Topic; Coronavirus Infections; Drug Repositioning; Humans; Multicenter Studies as Topic; Pneumonia, Viral","(2020) National Health Commission of the People's Republic of China, , http://www.nhc.gov.cn/xcs/yqfkdt/202002/18546da875d74445bb537ab014e7a1c6.shtml, accessed February 17 (in Chinese); Lu, H., Drug treatment options for the 2019-new coronavirus (2019-nCoV) (2020) Biosci Trends; Audio transcript of the news briefing held by the State Council of China on February 17, 2020 (2020) The National Health Commission of the People's Republic of China, , http://www.nhc.gov.cn/xcs/yqfkdt/202002/f12a62d10c2a48c6895cedf2faea6e1f.shtml, accessed February 18 (in Chinese); Wang, M., Cao, R., Zhang, L., Yang, X., Liu, J., Xu, M., Shi, Z., Xiao, G., Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro (2020) Cell Res; (2019), http://www.chictr.org.cn/searchproj.aspx, accessed February 18; Savarino, A., Boelaert, J.R., Cassone, A., Majori, G., Cauda, R., Effects of chloroquine on viral infections: an old drug against today's diseases (2003) Lancet Infect Dis, 3, pp. 722-727; Yan, Y., Zou, Z., Sun, Y., Li, X., Xu, K.F., Wei, Y., Jin, N., Jiang, C., Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model (2013) Cell Res, 23, pp. 300-302","Gao, J.; Department of Pharmacology, School of Pharmacy, Qingdao UniversityChina; email: gaojj@qdu.edu.cn",,"International Advancement Center for Medicine and Health Research Co., Ltd.",18817815,,,32074550,English,BioScience Trends,Letter,Final,Open Access,Scopus,2-s2.0-85080879659,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Givi B., Schiff B.A., Chinn S.B., Clayburgh D., Iyer N.G., Jalisi S., Moore M.G., Nathan C.-A., Orloff L.A., O'Neill J.P., Parker N., Zender C., Morris L.G.T., Davies L.",15623110800;7004355564;34975246500;6506068782;35322379100;35268697400;8333237400;7102463457;7003826992;57216138001;57215968248;6603400517;7201727299;13406943900;,Safety Recommendations for Evaluation and Surgery of the Head and Neck during the COVID-19 Pandemic,2020,JAMA Otolaryngology - Head and Neck Surgery,,,,,,,,10.1001/jamaoto.2020.0780,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082502485&doi=10.1001%2fjamaoto.2020.0780&partnerID=40&md5=1debca7758e8083256b310a536955c84,"Department of Otolaryngology, NYU Langone Health, 160 E 34th St, New York, NY 10016, United States; Department of Otolaryngology, Montefiore Medical Center, New York, NY, United States; Department of Otolaryngology, University of Michigan, Ann Arbor, United States; Department of Otolaryngology, Oregon Health and Science University, Portland, United States; Department of Head and Neck Surgery, Singapore General Hospital, National Cancer Centre, Singapore, Singapore; Department of Otolaryngology, Beth Israel Deaconess Medical Center, Boston, MA, United States; Department of Otolaryngology, Indiana University School of Medicine, Indianapolis, United States; Department of Otolaryngology, Louisiana State University, Shreveport, United States; Department of Otolaryngology, Stanford University, Palo Alto, CA, United States; Department of Otolaryngology, Beaumont Hospital, Royal College of Surgeons in Ireland, Dublin, Ireland; Department of Otolaryngology, University of Cincinnati, Cincinnati, OH, United States; Head and Neck Service, Memorial Sloan Kettering Cancer Center, New York, NY, United States; Department of Veterans Affairs, White River Junction, VT, United States","Givi, B., Department of Otolaryngology, NYU Langone Health, 160 E 34th St, New York, NY 10016, United States; Schiff, B.A., Department of Otolaryngology, Montefiore Medical Center, New York, NY, United States; Chinn, S.B., Department of Otolaryngology, University of Michigan, Ann Arbor, United States; Clayburgh, D., Department of Otolaryngology, Oregon Health and Science University, Portland, United States; Iyer, N.G., Department of Head and Neck Surgery, Singapore General Hospital, National Cancer Centre, Singapore, Singapore; Jalisi, S., Department of Otolaryngology, Beth Israel Deaconess Medical Center, Boston, MA, United States; Moore, M.G., Department of Otolaryngology, Indiana University School of Medicine, Indianapolis, United States; Nathan, C.-A., Department of Otolaryngology, Louisiana State University, Shreveport, United States; Orloff, L.A., Department of Otolaryngology, Stanford University, Palo Alto, CA, United States; O'Neill, J.P., Department of Otolaryngology, Beaumont Hospital, Royal College of Surgeons in Ireland, Dublin, Ireland; Parker, N., Department of Otolaryngology, Indiana University School of Medicine, Indianapolis, United States; Zender, C., Department of Otolaryngology, University of Cincinnati, Cincinnati, OH, United States; Morris, L.G.T., Head and Neck Service, Memorial Sloan Kettering Cancer Center, New York, NY, United States; Davies, L., Department of Veterans Affairs, White River Junction, VT, United States","Importance: The rapidly expanding novel coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2, has challenged the medical community to an unprecedented degree. Physicians and health care workers are at added risk of exposure and infection during the course of patient care. Because of the rapid spread of this disease through respiratory droplets, health care workers who come in close contact with the upper aerodigestive tract during diagnostic and therapeutic procedures, such as otolaryngologists-head and neck surgeons, are particularly at risk. A set of safety recommendations was created based on a review of the literature and communications with physicians with firsthand knowledge of safety procedures during the COVID-19 pandemic. Observations: A high number of health care workers were infected during the first phase of the pandemic in the city of Wuhan, China. Subsequently, by adopting strict safety precautions, other regions were able to achieve high levels of safety for health care workers without jeopardizing the care of patients. The most common procedures related to the examination and treatment of upper aerodigestive tract diseases were reviewed. Each category was reviewed based on the potential risk imposed to health care workers. Specific recommendations were made based on the literature, when available, or consensus best practices. Specific safety recommendations were made for performing tracheostomy in patients with COVID-19. Conclusions and Relevance: Preserving a highly skilled health care workforce is a top priority for any community and health care system. Based on the experience of health care systems in Asia and Europe, by following strict safety guidelines, the risk of exposure and infection of health care workers could be greatly reduced while providing high levels of care. The provided recommendations, which may evolve over time, could be used as broad guidance for all health care workers who are involved in the care of patients with COVID-19.. © 2020 Cambridge University Press. All rights reserved.",,,"Wang, D., Hu, B., Hu, C., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) JAMA, , http://jamanetwork.com/article.aspx?doi=10.1001/jama.2020.1585, [published online February 7], doi: 32031570; Moore, D., Gamage, B., Bryce, E., Copes, R., Yassi, A., Protecting health care workers from SARS and other respiratory pathogens: Organizational and individual factors that affect adherence to infection control guidelines (2005) Am J Infect Control, 33 (2), pp. 88-96. , http://dx.doi.org/10.1016/j.ajic.2004.11.003, doi: PMID 15761408; Ng, K., Poon, B.H., Kiat Puar, T.H., COVID-19 and the risk to health care workers: A case report (2020) Ann Intern Med, , http://dx.doi.org/10.7326/L20-0175, doi: PMID 32176257; Guidance for ENT during the COVID-19 Pandemic, , https://www.entuk.org/guidance-ent-during-covid-19-pandemic, Accessed March 23, 2020; Siddiqui, S., CMS Adult Elective Surgery and Procedures Recommendations [Version 3.15.20], , https://www.cms.gov/files/document/31820-cms-adult-elective-surgery-and-procedures-recommendations.pdf, Accessed March 23, 2020; Tay, J.K., Khoo, M.-C., Loh, W.S., Surgical considerations for tracheostomy during the COVID-19 pandemic: Lessons learned from the severe acute respiratory syndrome outbreak (2020) JAMA Otolaryngol Head Neck Surg, , http://jamanetwork.com/article.aspx?doi=10.1001/jamaoto.2020.0764, [published online March 31]; Roberts, V., To PAPR or not to PAPR? (2014) Can J Respir Ther, 50 (3), pp. 87-90. , PMID 26078617; (2015) The Use and Effectiveness of Powered Air Purifying Respirators in Health Care: Workshop Summary, , National Academies Press; Wax, R.S., Christian, M.D., Practical recommendations for critical care and anesthesiology teams caring for novel coronavirus (2019-nCoV) patients (2020) Can J Anaesth, , http://dx.doi.org/10.1007/s12630-020-01591-x, [published online February 12], doi: PMID 32052373; Interim Infection Prevention and Control Recommendations for Patients with Suspected or Confirmed Coronavirus Disease (COVID-19) in Healthcare Settings, , https://www.cdc.gov/coronavirus/2019-ncov/infection-control/control-recommendations.html, Accessed March 23, 2020; Zou, L., Ruan, F., Huang, M., SARS-CoV-2 viral load in upper respiratory specimens of infected patients (2020) N Engl J Med, 382 (12), pp. 1177-1179. , http://dx.doi.org/10.1056/NEJMc2001737, doi: PMID 32074444; Van Doremalen, N., Bushmaker, T., Morris, D.H., Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1 (2020) N Engl J Med, , http://dx.doi.org/10.1056/NEJMc2004973, [published online March 17], doi: PMID 32182409; COVID-19: Guidance for Triage of Non-emergent Surgical Procedures, , https://www.facs.org/covid-19/clinical-guidance/triage, Accessed March 23, 2020; Zheng, M.H., Boni, L., Fingerhut, A., Minimally invasive surgery and the novel coronavirus outbreak: Lessons learned in China and Italy (2020) Ann Surg, , https://journals.lww.com/annalsofsurgery/Documents/Minimally%20invasive%20surgery%20and%20the%20novel%20coronavirus%20outbreak%20-%20lessons%20learned%20in%20China%20and%20Italy.pdf, [published online March 15], Accessed March 23, 2020; Patel, Z.M., Hwang, P.H., Nayak, J.V., Statement from Stanford University School of Medicine Departments of Otolaryngology-Head and Neck Surgery and Neurosurgery, , https://www.docdroid.net/AyUBOji/covid-19-information.pdf, Accessed March 23, 2020; Isakbaeva, E.T., Khetsuriani, N., Beard, R.S., SARS-associated coronavirus transmission, United States (2004) Emerg Infect Dis, 10 (2), pp. 225-231. , http://dx.doi.org/10.3201/eid1002.030734, doi: PMID 15030687; Ding, Y., He, L., Zhang, Q., Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: Implications for pathogenesis and virus transmission pathways (2004) J Pathol, 203 (2), pp. 622-630. , http://dx.doi.org/10.1002/path.1560, doi: PMID 15141376; Pitkäranta, A., Virolainen, A., Jero, J., Arruda, E., Hayden, F.G., Detection of rhinovirus, respiratory syncytial virus, and coronavirus infections in acute otitis media by reverse transcriptase polymerase chain reaction (1998) Pediatrics, 102 (2), pp. 291-295. , http://dx.doi.org/10.1542/peds.102.2.291, doi: PMID 9685428; Heikkinen, T., Thint, M., Chonmaitree, T., Prevalence of various respiratory viruses in the middle ear during acute otitis media (1999) N Engl J Med, 340 (4), pp. 260-264. , http://dx.doi.org/10.1056/NEJM199901283400402, doi: PMID 9920949; Murthy, S., Gomersall, C.D., Fowler, R.A., Care for critically ill patients with COVID-19 (2020) JAMA, , http://jamanetwork.com/article.aspx?doi=10.1001/jama.2020.3633, [published online March 11], doi: PMID 32159735; Young, D., Harrison, D.A., Cuthbertson, B.H., Rowan, K., Effect of early vs late tracheostomy placement on survival in patients receiving mechanical ventilation: The TracMan randomized trial (2013) JAMA, 309 (20), pp. 2121-2129. , http://jamanetwork.com/article.aspx?doi=10.1001/jama.2013.5154, doi: PMID 23695482; Gawande, A., Keeping the coronavirus from infecting health-care workers: What Singapore's and Hong Kong's success is teaching us about the pandemic (2020) The New Yorker, , https://www.newyorker.com/news/news-desk/keeping-the-coronavirus-from-infecting-health-care-workers, March 21, Accessed March 23, 2020","Givi, B.; Department of Otolaryngology, NYU Langone Health, 160 E 34th St, United States; email: babak.givi@nyulangone.org",,American Medical Association,21686181,,,,English,JAMA Otolaryngol. Head Neck Surg.,Article,Article in Press,Open Access,Scopus,2-s2.0-85082502485,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Cai Q., Yang M., Liu D., Chen J., Shu D., Xia J., Liao X., Gu Y., Cai Q., Yang Y., Shen C., Li X., Peng L., Huang D., Zhang J., Zhang S., Wang F., Liu J., Chen L., Chen S., Wang Z., Zhang Z., Cao R., Zhong W., Liu Y., Liu L.",57215933398;57215932581;57215933460;57215782223;57215937317;57215935704;57215935142;57215934458;57215933395;57215379404;57215934081;57215937395;57207695610;57215936001;57214827020;57215934299;57214893775;57215934553;57203143511;57215933172;57214896826;57214755874;36167910100;35424990900;7410218226;57190174032;,Experimental Treatment with Favipiravir for COVID-19: An Open-Label Control Study,2020,Engineering,,,,,,,,10.1016/j.eng.2020.03.007,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082424157&doi=10.1016%2fj.eng.2020.03.007&partnerID=40&md5=3346cf872202a3d3dbe4b0c3b012b0f8,"National Clinical Research Center for Infectious Diseases, The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, 518100, China; National Engineering Research Center for the Emergence Drugs, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China","Cai, Q., National Clinical Research Center for Infectious Diseases, The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, 518100, China; Yang, M., National Clinical Research Center for Infectious Diseases, The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, 518100, China; Liu, D., National Clinical Research Center for Infectious Diseases, The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, 518100, China; Chen, J., National Clinical Research Center for Infectious Diseases, The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, 518100, China; Shu, D., National Clinical Research Center for Infectious Diseases, The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, 518100, China; Xia, J., National Clinical Research Center for Infectious Diseases, The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, 518100, China; Liao, X., National Clinical Research Center for Infectious Diseases, The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, 518100, China; Gu, Y., National Clinical Research Center for Infectious Diseases, The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, 518100, China; Cai, Q., National Clinical Research Center for Infectious Diseases, The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, 518100, China; Yang, Y., National Clinical Research Center for Infectious Diseases, The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, 518100, China; Shen, C., National Clinical Research Center for Infectious Diseases, The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, 518100, China; Li, X., National Clinical Research Center for Infectious Diseases, The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, 518100, China; Peng, L., National Clinical Research Center for Infectious Diseases, The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, 518100, China; Huang, D., National Clinical Research Center for Infectious Diseases, The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, 518100, China; Zhang, J., National Clinical Research Center for Infectious Diseases, The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, 518100, China; Zhang, S., National Clinical Research Center for Infectious Diseases, The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, 518100, China; Wang, F., National Clinical Research Center for Infectious Diseases, The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, 518100, China; Liu, J., National Clinical Research Center for Infectious Diseases, The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, 518100, China; Chen, L., National Clinical Research Center for Infectious Diseases, The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, 518100, China; Chen, S., National Clinical Research Center for Infectious Diseases, The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, 518100, China; Wang, Z., National Clinical Research Center for Infectious Diseases, The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, 518100, China; Zhang, Z., National Clinical Research Center for Infectious Diseases, The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, 518100, China; Cao, R., National Engineering Research Center for the Emergence Drugs, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China; Zhong, W., National Engineering Research Center for the Emergence Drugs, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China; Liu, Y., National Clinical Research Center for Infectious Diseases, The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, 518100, China; Liu, L., National Clinical Research Center for Infectious Diseases, The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, 518100, China","An outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and its caused coronavirus disease 2019 (COVID-19) has been reported in China since December 2019. More than 16% of patients developed acute respiratory distress syndrome, and the fatality ratio was about 1%–2%. No specific treatment has been reported. Herein, we examine the effects of Favipiravir (FPV) versus Lopinavir (LPV)/ritonavir (RTV) for the treatment of COVID-19. Patients with laboratory-confirmed COVID-19 who received oral FPV (Day 1: 1600 mg twice daily; Days 2–14: 600 mg twice daily) plus interferon (IFN)-α by aerosol inhalation (5 million U twice daily) were included in the FPV arm of this study, whereas patients who were treated with LPV/RTV (Days 1–14: 400 mg/100 mg twice daily) plus IFN-α by aerosol inhalation (5 million U twice daily) were included in the control arm. Changes in chest computed tomography (CT), viral clearance, and drug safety were compared between the two groups. For the 35 patients enrolled in the FPV arm and the 45 patients in the control arm, all baseline characteristics were comparable between the two arms. A shorter viral clearance time was found for the FPV arm versus the control arm (median (interquartile range, IQR), 4 (2.5–9) d versus 11 (8–13) d, P < 0.001). The FPV arm also showed significant improvement in chest imaging compared with the control arm, with an improvement rate of 91.43% versus 62.22% (P = 0.004). After adjustment for potential confounders, the FPV arm also showed a significantly higher improvement rate in chest imaging. Multivariable Cox regression showed that FPV was independently associated with faster viral clearance. In addition, fewer adverse reactions were found in the FPV arm than in the control arm. In this open-label nonrandomized control study, FPV showed significantly better treatment effects on COVID-19 in terms of disease progression and viral clearance; if causal, these results should be important information for establishing standard treatment guidelines to combat the SARS-CoV-2 infection. © 2020",Antiviral therapy; COVID-19; Favipiravir; Open-label nonrandomized control study; SARS-CoV-2,Aerosols; Computerized tomography; Controlled drug delivery; Disease control; Antiviral therapy; Control studies; COVID-19; Favipiravir; SARS-CoV-2; Diseases,"Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) JAMA, , Epub Feb 7; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395 (10223), pp. 497-506; Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med, , Epub Jan 29; Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395 (10223), pp. 507-513; http://en.nhc.gov.cn/DailyBriefing.html, National Health Commission of the People's Republic of China. Daily briefing on novel coronavirus cases in China [Internet]. Beijing: National Health Commission of the People's Republic of China 2020 [updated 2020 Mar 12; cited 2020 Feb 25]. Available form:; Lu, R., Zhao, X., Li, J., Niu, P., Yang, B., Wu, H., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet, 395 (10224), pp. 565-574; Wang, M., Cao, R., Zhang, L., Yang, X., Liu, J., Xu, M., Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro (2020) Cell Res, 30, pp. 269-271; Oestereich, L., Lüdtke, A., Wurr, S., Rieger, T., Muñoz-Fontela, C., Günther, S., Successful treatment of advanced Ebola virus infection with T-705 (favipiravir) in a small animal model (2014) Antiviral Res, 105, pp. 17-21; Grieser, C., Goldmann, A., Steffen, I.G., Kastrup, M., Fernández, C.M., Engert, U., Computed tomography findings from patients with ARDS due to Influenza A (H1N1) virus-associated pneumonia (2012) Eur J Radiol, 81 (2), pp. 389-394; Chang, Y., Yu, C., Chang, S., Galvin, J.R., Liu, H., Hsiao, C., Pulmonary sequelae in convalescent patients after severe acute respiratory syndrome: evaluation with thin-section CT (2005) Radiology, 236 (3), pp. 1067-1075; Madelain, V., Oestereich, L., Graw, F., Nguyen, T.H., De Lamballerie, X., Mentré, F., Ebola virus dynamics in mice treated with favipiravir (2015) Antiviral Res, 123, pp. 70-77; Sissoko, D., Laouenan, C., Folkesson, E., M'lebing, A.B., Beavogui, A.H., Baize, S., Experimental treatment with favipiravir for Ebola virus disease (the JIKI Trial): a historically controlled, single-arm proof-of-concept trial in Guinea (2016) PLoS Med, 13 (3); Furuta, Y., Gowen, B.B., Takahashi, K., Shiraki, K., Smee, D.F., Barnard, D.L., Favipiravir (T-705), a novel viral RNA polymerase inhibitor (2013) Antiviral Res, 100 (2), pp. 446-454; Bouazza, N., Treluyer, J.M., Foissac, F., Mentré, F., Taburet, A.M., Guedj, J., Favipiravir for children with Ebola (2015) Lancet, 385 (9968), pp. 603-604; MDVI, L.L.C., https://clinicaltrials.gov/ct2/show/NCT02008344, Phase 3 efficacy and safety study of favipiravir for treatment of uncomplicated influenza in adults [Internet]. Bethesda (MD): National Library of Medicine [update 2015 Nov 11; cited 2020 Mar 7]. Available from:; Chafekar, A., Fielding, B.C., MERS-CoV: understanding the latest human coronavirus threat (2018) Viruses, 10 (2), p. E93","Zhong, W.; National Engineering Research Center for the Emergence Drugs, Beijing Institute of Pharmacology and ToxicologyChina; email: zhongwu@bmi.ac.cn",,Elsevier Ltd,20958099,,,,English,Engineering,Article,Article in Press,Open Access,Scopus,2-s2.0-85082424157,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Li L., Zhang Q., Wang X., Zhang J., Wang T., Gao T., Duan W., Tsoi K.K., Wang F.",57195739598;36448087800;57005000100;57214598824;57206719567;57215117904;57216041247;16065259000;57216134202;,Characterizing the Propagation of Situational Information in Social Media During COVID-19 Epidemic: A Case Study on Weibo,2020,IEEE Transactions on Computational Social Systems,,,,,,,,10.1109/TCSS.2020.2980007,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082509229&doi=10.1109%2fTCSS.2020.2980007&partnerID=40&md5=c91c7b0ba697de00ceac5df57c7b5dcc,"School of Public Administration, South China University of Technology, Guangzhou 510641, China.; School of Data Science, City University of Hong Kong, Hong Kong (e-mail: qingpeng.zhang@cityu.edu.hk); Institute of Automation, Chinese Academy of Sciences, Beijing 100864, China.; School of Electrical and Automation, Wuhan University, Wuhan 430072, China.; College of Systems Engineering, National University of Defense Technology, Changsha 410073, China.; JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong.","Li, L., School of Public Administration, South China University of Technology, Guangzhou 510641, China.; Zhang, Q., School of Data Science, City University of Hong Kong, Hong Kong (e-mail: qingpeng.zhang@cityu.edu.hk); Wang, X., Institute of Automation, Chinese Academy of Sciences, Beijing 100864, China.; Zhang, J., School of Electrical and Automation, Wuhan University, Wuhan 430072, China.; Wang, T., College of Systems Engineering, National University of Defense Technology, Changsha 410073, China.; Gao, T., School of Electrical and Automation, Wuhan University, Wuhan 430072, China.; Duan, W., College of Systems Engineering, National University of Defense Technology, Changsha 410073, China.; Tsoi, K.K., JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong.; Wang, F., Institute of Automation, Chinese Academy of Sciences, Beijing 100864, China.","During the ongoing outbreak of coronavirus disease (COVID-19), people use social media to acquire and exchange various types of information at a historic and unprecedented scale. Only the situational information are valuable for the public and authorities to response to the epidemic. Therefore, it is important to identify such situational information and to understand how it is being propagated on social media, so that appropriate information publishing strategies can be informed for the COVID-19 epidemic. This article sought to fill this gap by harnessing Weibo data and natural language processing techniques to classify the COVID-19-related information into seven types of situational information. We found specific features in predicting the reposted amount of each type of information. The results provide data-driven insights into the information need and public attention. IEEE",COVID-19; crisis information sharing; infectious disease; information propagation; social media; social network analysis.,Epidemiology; Information dissemination; Natural language processing systems; Social networking (online); COVID-19; Infectious disease; Information propagation; Information sharing; Social media; Classification (of information),,,,Institute of Electrical and Electronics Engineers Inc.,2329924X,,,,English,IEEE Trans. Computat. Soc. Syst.,Article,Article in Press,,Scopus,2-s2.0-85082509229,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zheng Y., Goh E., Wen J.",57215966506;26534181500;57196723257;,The effects of misleading media reports about COVID-19 on Chinese tourists’ mental health: a perspective article,2020,Anatolia,,,,,,,,10.1080/13032917.2020.1747208,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082465501&doi=10.1080%2f13032917.2020.1747208&partnerID=40&md5=05c796bd7910ba864e5cbc7a34c9d9b8,"School of Management and Tourism, Fujian Agriculture and Forestry University, Fuzhou, Fujian, China; School of Business and Law, Edith Cowan University, Joondalup, WA, Australia","Zheng, Y., School of Management and Tourism, Fujian Agriculture and Forestry University, Fuzhou, Fujian, China; Goh, E., School of Business and Law, Edith Cowan University, Joondalup, WA, Australia; Wen, J., School of Business and Law, Edith Cowan University, Joondalup, WA, Australia","The novel coronavirus (COVID-19) has been declared apublic health emergency of international concern by the World Health Organization. This pandemic has since saturated the headlines of major international media channels that disseminate information to global citizens. However, some media coverage of COVID-19 has negatively influenced Chinese travellers’ mental health due to the outbreak having been labelled “Chinese virus pandemonium.” Key world leaders have also parroted such sensationalism; for example, President Donald Trump called COVID-19 the “Chinese virus”. This discriminatory labelling has resulted in violent attacks on Chinese international travellers and students. This perspective article explores how misleading and discriminatory media reports may affect the mental well-being of ethnically Chinese travellers during the global COVID-19 pandemic. © 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group.",COVID-19 outbreak; media coverage; mental health; misleading information; psychological well-being,,"Coronavirus is a public health emergency (2020) World Health Organisation declares, , https://www.abc.net.au/news/2020-01-31/who-coronavirus-global-emergency/11916276; (2020) Coronavirus: Europe now epicentre of the pandemic, says WHO, , https://www.bbc.com/news/world-europe-51876784, March, 13; Goudsmit, E., Howes, S., Bias, misleading information and lack of respect for alternative views have distorted perceptions of myalgic encephalomyelitis/chronic fatigue syndrome and its treatment (2017) Journal of Health Psychology, 22 (9), pp. 1159-1167. , https://doi.org/10.1177/1359105317707216; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Cao, B., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) The Lancet, 395 (10223), pp. 497-506. , https://doi.org/10.1016/S0140-6736(20)30183-5; Liu, S., Saif, L., Emerging viruses without borders: The Wuhan coronavirus (2020) Viruses, 12 (2). , https://doi.org/10.3390/v12020130; Ryff, C., Keyes, C., The structure of psychological well-being revisited (1995) Journal of Personality and Social Psychology, 69 (4), pp. 719-727. , https://doi.org/10.1037/0022-3514.69.4.719; Sheth, S., Photos of Trump’s prepared remarks for Thursday’s White House briefing show he altered ‘Corona virus’ to ‘Chinese virus’ (2020) Business Insider, , https://www.businessinsider.com.au/photos-trump-altered-coronavirus-to-chinese-virus-remarks-2020-3?r=US&IR=T; Shi, Z., Hu, Z., A review of studies on animal reservoirs of the SARS coronavirus (2008) Virus Research, 133 (1), pp. 74-87. , https://doi.org/10.1016/j.virusres.2007.03.012; Wen, J., Aston, J., Liu, X., Ying, T., Effects of misleading media coverage on public health crisis: A case of the 2019 novel coronavirus outbreak in China (2020) Anatolia: An International Journal of Tourism and Hospitality Research, pp. 1-6. , https://doi.org/10.1080/13032917.2020.1730621; (2005) Promoting mental health: Concepts, emerging evidence, practice, , WHO; (2020) Novel coronavirus (2019-nCoV): Situation report–8, , https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200128-sitrep-8-ncov-cleared.pdf; Ying, T., Wang, K., Liu, X., Wen, J., Goh, E., Rethinking game consumption in tourism: A case of the 2019 novel coronavirus pneumonia outbreak in China (2020) Tourism Recreation Research, pp. 1-6. , https://doi.org/10.1080/02508281.2020.1743048; Yong, C., UK police release images of 4 men linked to COVID-19 racist attack on Singaporean student in London (2020) The Straits Times Singapore, , https://www.straitstimes.com/singapore/uk-police-release-images-of-4-men-linked-to-covid-19-racism-attack-on-singaporean-student; Zhao, I., Coronavirus has sparked racist attacks on Asians in Australia (2020) ABC News, , https://www.abc.net.au/news/2020-02-01/coronavirus-has-sparked-racist-attacks-on-asian-australians/11918962","Wen, J.; School of Business and Law, Edith Cowan UniversityAustralia; email: j.wen@ecu.edu.au",,Routledge,13032917,,,,English,Anatolia,Note,Article in Press,,Scopus,2-s2.0-85082465501,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Giovanetti M., Angeletti S., Benvenuto D., Ciccozzi M.",55486066500;7003426796;57208408457;8791594200;,A doubt of multiple introduction of SARS-CoV-2 in Italy: A preliminary overview,2020,Journal of Medical Virology,,,,,,,,10.1002/jmv.25773,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082431847&doi=10.1002%2fjmv.25773&partnerID=40&md5=bce7ce1a907fbe573677a7c5e09890a1,"Laboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil; Laboratório de Genética Celular e Molecular, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome, Rome, Italy; Unit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome, Rome, Italy","Giovanetti, M., Laboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil, Laboratório de Genética Celular e Molecular, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil; Angeletti, S., Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome, Rome, Italy; Benvenuto, D., Unit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome, Rome, Italy; Ciccozzi, M., Unit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome, Rome, Italy","The emergence of the novel betacoronavirus, recently renamed as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has raised serious concerns due to the virus's rapid dissemination worldwide. Nevertheless, there is limited information about the genomic epidemiology of SARS-CoV-2 circulating in Italy from surveillance studies. The shortage of complete genomic sequences available impairs our understanding of the SARS-CoV-2 introduction and establishment in the country. To better understand its dynamics in Italy, we analyzed complete genomes of SARS-CoV-2 isolates, obtained directly from clinical samples. Our phylogenetic reconstructions suggest possible multiple introduction of SARS-CoV-2. Continued genomic surveillance strategies are needed to improve monitoring and understanding of the current SARS-CoV-2 epidemics, which might help to attenuate public health impact of infectious diseases. © 2020 Wiley Periodicals, Inc.",COVID-19; epidemic; Italian outbreak; phylogenetic inference,,"Cui, J., Li, F., Shi, Z.-L., Origin and evolution of pathogenic coronaviruses (2019) Nat Rev Microbiol, 17 (3), pp. 181-192; Schoeman, D., Fielding, B.C., Coronavirus envelope protein: current knowledge (2019) Virol J, 16 (1), p. 69; Peiris, J.S., Guan, Y., Yuen, K.Y., Severe acute respiratory syndrome (2004) Nat Med, 10, pp. S88-S97; Zaki, A.M., van Boheemen, S., Bestebroer, T.M., Osterhaus, A.D., Fouchier, R.A., Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia (2012) N Engl J Med, 367, pp. 1814-1820; Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382 (8), pp. 727-733; Benvenuto, D., Giovanetti, M., Ciccozzi, A., Spoto, S., Angeletti, S., Ciccozzi, M., The 2019-new coronavirus epidemic: evidence for virus evolution (2020) J Med Virol, 92, pp. 455-459; (2020) Coronavirus disease 2019 (COVID-19) Situation Report – 46, , https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200306-sitrep-46-covid-19.pdf?sfvrsn=96b04adf_2, March; (2020) Novel Coronavirus (2019-nCoV) Situation Report – 19, , https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200208-sitrep-19-ncov.pdf, February; (2020) COVID-19 - Situazione in Italia, , http://www.salute.gov.it/portale/nuovocoronavirus/dettaglioContenutiNuovoCoronavirus.jsp?lingua=italiano&id=5351&area=nuovoCoronavirus&menu=vuoto, March; Katoh, K., Rozewicki, J., Yamada, K.D., MAFFT online service: multiple sequence alignment, interactive sequence choice and visualization (2019) Brief Bioinform, 20 (4), pp. 1160-1166; Nguyen, L.T., Schmidt, H.A., von Haeseler, A., Minh, B.Q., IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies (2015) Mol Biol Evol, 32 (1), pp. 268-274; Darriba, D., Taboada, G.L., Doallo, R., Posada, D., jModelTest 2: more models, new heuristics and parallel computing (2012) Nat Methods, 9 (8), p. 772; Benvenuto, D., Giovanetti, M., Salemi, M., The global spread of 2019-nCoV: a molecular evolutionary analysis (2020) Pathog Glob Health, 12, pp. 1-4","Angeletti, S.; Unit of Clinical Laboratory Science, University Campus Bio-Medico of RomeItaly; email: s.angeletti@unicampus.it",,John Wiley and Sons Inc.,1466615,,JMVID,32190908,English,J. Med. Virol.,Article,Article in Press,Open Access,Scopus,2-s2.0-85082431847,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Algaissi A., Hashem A.M.",57046024300;57200589744;,Evaluation of MERS-CoV neutralizing antibodies in sera using live virus microneutralization assay,2020,Methods in Molecular Biology,2099,,,107,116,,,10.1007/978-1-0716-0211-9_9,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077344359&doi=10.1007%2f978-1-0716-0211-9_9&partnerID=40&md5=c8a75e47a05d2cc720c414918e8d00da,"Departments of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, United States; Department of Medical Laboratories Technology, College of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia; Department of Medical Microbiology and Parasitology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia; Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia","Algaissi, A., Departments of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, United States, Department of Medical Laboratories Technology, College of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia; Hashem, A.M., Department of Medical Microbiology and Parasitology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia, Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia","The microneutralization (MN) assay is a standard and important technique in virology, immunology, and epidemiology. It is a highly specific and sensitive assay for evaluating virus-specific neutralizing antibodies (nAbs) in human and animal sera. It provides the most precise answer to whether or not an individual or animal has antibodies that can neutralize or inhibit the infectivity of a specific virus strain. However, using live virus-based MN assay might require working under high containment facilities especially when dealing with high-risk pathogens such as the Middle East respiratory syndrome-coronavirus (MERS-CoV). In this chapter, we describe the isolation, amplification, and titration of MERS-CoV, as well as detailed MN assay to measure nAb levels in sera from different mammalian species. © Springer Science+Business Media, LLC, part of Springer Nature 2020.",MERS-CoV; Microneutralization; Neutralizing antibodies,,"Zaki, A.M., van Boheemen, S., Bestebroer, T.M., Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia (2012) N Engl J Med, 367, pp. 1814-1820. , https://doi.org/10.1056/NEJMoa1211721; Alagaili, A.N., Briese, T., Mishra, N., Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia (2014) Mbio, 5, p. e00884. , https://doi.org/10.1128/mBio.00884-14; Azhar, E.I., El-Kafrawy, S.A., Farraj, S.A., Evidence for camel-to-human transmission of MERS coronavirus (2014) N Engl J Med, 370, pp. 2499-2505. , https://doi.org/10.1056/NEJMoa1401505; Poissy, J., Goffard, A., Parmentier-Decrucq, E., Kinetics and pattern of viral excretion in biological specimens of two MERS-CoV cases (2014) J Clin Virol, 61, pp. 275-278. , https://doi.org/10.1016/j.jcv.2014.07.002; Müller, M.A., Meyer, B., Corman, V.M., Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: A nationwide, cross-sectional, serological study (2015) Lancet Infect Dis, 15, pp. 559-564. , https://doi.org/10.1016/S1473-3099(15)70090-3; Corman, V.M., Albarrak, A.M., Omrani, A.S., Viral shedding and antibody response in 37 patients with Middle East respiratory syndrome coronavirus infection (2016) Clin Infect Dis, 62, pp. 477-483. , https://doi.org/10.1093/cid/civ951; Zhao, J., Alshukairi, A.N., Baharoon, S.A., Recovery from the Middle East respiratory syndrome is associated with antibody and T-cell responses (2017) Sci Immunol, 2. , https://doi.org/10.1126/sciimmunol.aan5393; Al-Amri, S.S., Abbas, A.T., Siddiq, L.A., Immunogenicity of candidate MERS-CoV DNA vaccines based on the spike protein (2017) Sci Rep, 7. , https://doi.org/10.1038/srep44875; Perera, R.A., Wang, P., Gomaa, M.R., Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt, June 2013 (2013) Euro Surveill, 18; Reusken, C., Mou, H., Godeke, G.J., Specific serology for emerging human coronaviruses by protein microarray (2013) Euro Surveill, 18; Al-Abdallat, M.M., Payne, D.C., Alqasrawi, S., Hospital-associated outbreak of Middle East respiratory syndrome coronavirus: A serologic, epidemiologic, and clinical description (2014) Clin Infect Dis, 59, pp. 1225-1233. , https://doi.org/10.1093/cid/ciu359; Hemida, M.G., Perera, R.A., Al Jassim, R.A., Seroepidemiology of Middle East respiratory syndrome (MERS) coronavirus in Saudi Arabia (1993) and Australia (2014) and char-acterisation of assay specificity (2014) Euro Surveill, 19; Kleine-Weber, H., Elzayat, M.T., Wang, L., Inability of rat DPP4 to allow MERS-CoV infection revealed by using a VSV pseudotype bearing truncated MERS-CoV spike protein (2015) Arch Virol, 160, pp. 2293-2300. , https://doi.org/10.1128/JVI.01381-18; Park, S.W., Perera, R.A., Choe, P.G., Comparison of serological assays in human Middle East respiratory syndrome (MERS)-coronavirus infection (2015) Euro Surveill, 20. , https://doi.org/10.2807/1560-7917.ES.2015.20.41.30042; Fukushi, S., Fukuma, A., Kurosu, T., Characterization of novel monoclonal antibodies against the MERS-coronavirus spike protein and their application in species-independent antibody detection by competitive ELISA (2017) J Virol Methods, 251, pp. 22-29. , https://doi.org/10.1016/j.jviromet.2017.10.008; Trivedi, S., Miao, C., Al-Abdallat, M.M., Inclusion of MERS-spike protein ELISA in algorithm to determine serologic evidence of MERS-CoV infection (2017) J Med Virol, 90, pp. 367-371. , https://doi.org/10.1002/jmv.24948; Hashem, A.M., Al-Amri, S.S., Al-Subhi, T.L., Development and validation of different indirect ELISAs for MERS-CoV serological testing (2019) J Immunol Methods, 466, pp. 41-46. , https://doi.org/10.1016/j.jim.2019.01.005; Reed, L.J., Muench, H., A simple method of estimating fifty per cent endpoints (1938) Am J Epidemiol, 27, pp. 493-497","Hashem, A.M.; Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz UniversitySaudi Arabia; email: amhashem@kau.edu.sa",,Humana Press Inc.,10643745,,,31883091,English,Methods Mol. Biol.,Book Chapter,Final,Open Access,Scopus,2-s2.0-85077344359,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Qiu Y., Zhao Y.-B., Wang Q., Li J.-Y., Zhou Z.-J., Liao C.-H., Ge X.-Y.",57214161427;57210289205;57207885215;57192312600;57215606676;57215935115;35781787600;,Predicting the angiotensin converting enzyme 2 (ACE2) utilizing capability as the receptor of SARS-CoV-2,2020,Microbes and Infection,,,,,,,,10.1016/j.micinf.2020.03.003,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082509207&doi=10.1016%2fj.micinf.2020.03.003&partnerID=40&md5=3f2ada1a3d192113352baa201cb55068,"Hunan Provincial Key Laboratory of Medical Virology, Institute of Pathogen Biology and Immunology, College of Biology, Hunan University, 27 Tianma Rd., Changsha, Hunan 410012, China","Qiu, Y., Hunan Provincial Key Laboratory of Medical Virology, Institute of Pathogen Biology and Immunology, College of Biology, Hunan University, 27 Tianma Rd., Changsha, Hunan 410012, China; Zhao, Y.-B., Hunan Provincial Key Laboratory of Medical Virology, Institute of Pathogen Biology and Immunology, College of Biology, Hunan University, 27 Tianma Rd., Changsha, Hunan 410012, China; Wang, Q., Hunan Provincial Key Laboratory of Medical Virology, Institute of Pathogen Biology and Immunology, College of Biology, Hunan University, 27 Tianma Rd., Changsha, Hunan 410012, China; Li, J.-Y., Hunan Provincial Key Laboratory of Medical Virology, Institute of Pathogen Biology and Immunology, College of Biology, Hunan University, 27 Tianma Rd., Changsha, Hunan 410012, China; Zhou, Z.-J., Hunan Provincial Key Laboratory of Medical Virology, Institute of Pathogen Biology and Immunology, College of Biology, Hunan University, 27 Tianma Rd., Changsha, Hunan 410012, China; Liao, C.-H., Hunan Provincial Key Laboratory of Medical Virology, Institute of Pathogen Biology and Immunology, College of Biology, Hunan University, 27 Tianma Rd., Changsha, Hunan 410012, China; Ge, X.-Y., Hunan Provincial Key Laboratory of Medical Virology, Institute of Pathogen Biology and Immunology, College of Biology, Hunan University, 27 Tianma Rd., Changsha, Hunan 410012, China","SARS-CoV-2, the newly identified human coronavirus causing severe pneumonia pandemic, was probably originated from Chinese horseshoe bats. However, direct transmission of the virus from bats to humans is unlikely due to lack of direct contact, implying the existence of unknown intermediate hosts. Angiotensin converting enzyme 2 (ACE2) is the receptor of SARS-CoV-2, but only ACE2s of certain species can be utilized by SARS-CoV-2. Here, we evaluated and ranked the receptor-utilizing capability of ACE2s from various species by phylogenetic clustering and sequence alignment with the currently known ACE2s utilized by SARS-CoV-2. As a result, we predicted that SARS-CoV-2 tends to utilize ACE2s of various mammals, except murines, and some birds, such as pigeon. This prediction may help to screen the intermediate hosts of SARS-CoV-2. © 2020 Institut Pasteur",Angiotensin converting enzyme 2 (ACE2); Coronavirus; Phylogenetic analysis; Receptor utilization; SARS-CoV-2,,"Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382, pp. 727-733; Wu, F., Zhao, S., Yu, B., Chen, Y.M., Wang, W., Song, Z.G., A new coronavirus associated with human respiratory disease in China (2020) Nature, , [Epub ahead of print]; Chan, J.F., Yuan, S., Kok, K.H., To, K.K., Chu, H., Yang, J., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, 395, pp. 514-523; Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395, pp. 507-513; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506; Zhou, P., Yang, X.L., Wang, X.G., Hu, B., Zhang, L., Zhang, W., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature, 579 (7798), pp. 270-273; Bolles, M., Donaldson, E., Baric, R., SARS-CoV and emergent coronaviruses: viral determinants of interspecies transmission (2011) Curr Opin Virol, 1, pp. 624-634; Ge, X.Y., Li, J.L., Yang, X.L., Chmura, A.A., Zhu, G., Epstein, J.H., Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor (2013) Nature, 503, pp. 535-538; Song, H.D., Tu, C.C., Zhang, G.W., Wang, S.Y., Zheng, K., Lei, L.C., Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human (2005) Proc Natl Acad Sci U S A, 102, pp. 2430-2435; Shi, Z., Hu, Z., A review of studies on animal reservoirs of the SARS coronavirus (2008) Virus Res, 133, pp. 74-87; Ferrario, C.M., Trask, A.J., Jessup, J.A., Advances in biochemical and functional roles of angiotensin-converting enzyme 2 and angiotensin-(1-7) in regulation of cardiovascular function (2005) Am J Physiol Heart Circ Physiol, 289, pp. H2281-H2290; Donoghue, M., Hsieh, F., Baronas, E., Godbout, K., Gosselin, M., Stagliano, N., A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9 (2000) Circ Res, 87, pp. E1-E9; Kuba, K., Imai, Y., Rao, S., Gao, H., Guo, F., Guan, B., A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury (2005) Nat Med, 11, pp. 875-879; Li, W., Zhang, C., Sui, J., Kuhn, J.H., Moore, M.J., Luo, S., Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2 (2005) EMBO J, 24, pp. 1634-1643; Wan, Y., Shang, J., Graham, R., Baric, R.S., Li, F., Receptor recognition by novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS (2020) J Virol, , pii: JVI.00127-20. [Epub ahead of print]","Ge, X.-Y.; Hunan Provincial Key Laboratory of Medical Virology, Institute of Pathogen Biology and Immunology, College of Biology, Hunan University, 27 Tianma Rd., China; email: xyge@hnu.edu.cn",,Elsevier Masson SAS,12864579,,MCINF,32199943,English,Microbes Infect.,Article,Article in Press,Open Access,Scopus,2-s2.0-85082509207,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Sun J., He W.-T., Wang L., Lai A., Ji X., Zhai X., Li G., Suchard M.A., Tian J., Zhou J., Veit M., Su S.",57215831198;57194590327;57215835388;57215832074;57216121325;57194870460;57215834181;6603887291;57215829869;54682580100;17636877000;54918814500;,"COVID-19: Epidemiology, Evolution, and Cross-Disciplinary Perspectives",2020,Trends in Molecular Medicine,,,,,,,,10.1016/j.molmed.2020.02.008,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082016518&doi=10.1016%2fj.molmed.2020.02.008&partnerID=40&md5=31b28db3ec32897914b5e2e0b60f9682,"MOE Joint International Research Laboratory of Animal Health and Food Safety, Jiangsu Engineering Laboratory of Animal Immunology, Institute of Immunology and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China; College of Veterinary Medicine, China Agricultural University, Beijing, China; College of Natural, Applied, and Health Sciences, Kentucky State University, Frankfort, KY, United States; Department of Biomathematics, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA, United States; State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China; Key Laboratory of Animal Virology of Ministry of Agriculture, Zhejiang University, Hangzhou, China; Institute for Virology, Center for Infection Medicine, Veterinary Faculty, Free University Berlin, Berlin, Germany","Sun, J., MOE Joint International Research Laboratory of Animal Health and Food Safety, Jiangsu Engineering Laboratory of Animal Immunology, Institute of Immunology and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China; He, W.-T., MOE Joint International Research Laboratory of Animal Health and Food Safety, Jiangsu Engineering Laboratory of Animal Immunology, Institute of Immunology and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China; Wang, L., College of Veterinary Medicine, China Agricultural University, Beijing, China; Lai, A., College of Natural, Applied, and Health Sciences, Kentucky State University, Frankfort, KY, United States; Ji, X., Department of Biomathematics, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA, United States; Zhai, X., MOE Joint International Research Laboratory of Animal Health and Food Safety, Jiangsu Engineering Laboratory of Animal Immunology, Institute of Immunology and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China; Li, G., MOE Joint International Research Laboratory of Animal Health and Food Safety, Jiangsu Engineering Laboratory of Animal Immunology, Institute of Immunology and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China; Suchard, M.A., Department of Biomathematics, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA, United States; Tian, J., State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China; Zhou, J., Key Laboratory of Animal Virology of Ministry of Agriculture, Zhejiang University, Hangzhou, China; Veit, M., Institute for Virology, Center for Infection Medicine, Veterinary Faculty, Free University Berlin, Berlin, Germany; Su, S., MOE Joint International Research Laboratory of Animal Health and Food Safety, Jiangsu Engineering Laboratory of Animal Immunology, Institute of Immunology and College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China","The recent outbreak of COVID-19 in Wuhan turned into a public health emergency of international concern. With no antiviral drugs nor vaccines, and the presence of carriers without obvious symptoms, traditional public health intervention measures are significantly less effective. Here, we report the epidemiological and virological characteristics of the COVID-19 outbreak. Originated in bats, 2019-nCoV/ severe acute respiratory syndrome coronavirus (SARS-CoV)-2 likely experienced adaptive evolution in intermediate hosts before transfer to humans at a concentrated source of transmission. Similarities of receptor sequence binding to 2019-nCoV between humans and animals suggest a low species barrier for transmission of the virus to farm animals. We propose, based on the One Health model, that veterinarians and animal specialists should be involved in a cross-disciplinary collaboration in the fight against this epidemic. © 2020 Elsevier Ltd",,,"Gorbalenya, A.E., Severe acute respiratory syndrome-related coronavirus: the species and its viruses – a statement of the Coronavirus Study Group (2020) bioRxiv, , Published online February 11, 2020; Resta, S., Isolation and propagation of a human enteric coronavirus (2018) Science, 4717, pp. 978-981; Arabi, Y.M., Middle East Respiratory Syndrome (2017) N. Engl. J. Med., 376, pp. 584-594; Zhong, N.S., Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China, in February, 2003 (2003) Lancet, 362, pp. 1353-1358; Drosten, C., Identification of a novel coronavirus in patients with severe acute respiratory syndrome (2003) N. Engl. J. 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Infect. Dis., 10, pp. 1258-1263; Swerdlow, D.L., Finelli, L., Preparation for possible sustained transmission of 2019 novel coronavirus: lessons From previous epidemics (2020) JAMA, , Published online February 11, 2020; Park, J.E., MERS transmission and risk factors: a systematic review (2018) BMC Public Health, 18, p. 574; Paul, L.D., Complexity of the basic reproduction number (R0) (2019) Emerg. Infect. Dis., 25, pp. 1-4; Chen, N., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395, pp. 507-513; Pongpirul, W.A., Journey of a Thai taxi driver and novel coronavirus (2020) N. Engl. J. Med., , Published online February 12, 2020; Bastola, A., The first 2019 novel coronavirus case in Nepal (2020) Lancet Infect. Dis., 20, pp. 279-280; Holshue, M.L., First case of 2019 novel coronavirus in the United States (2020) N Engl. J. 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Biol. Evol., 33, pp. 1870-1874; Stamatakis, A., RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies (2014) Bioinformatics, 30, pp. 1312-1313","Veit, M.; Institute for Virology, Center for Infection Medicine, Veterinary Faculty, Free University BerlinGermany; email: Michael.Veit@fu-berlin.de",,Elsevier Ltd,14714914,,TMMRC,,English,Trends Mol. Med.,Review,Article in Press,Open Access,Scopus,2-s2.0-85082016518,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Gong F., Xiong Y., Xiao J., Lin L., Liu X., Wang D., Li X.",57193494576;57215780815;57206997079;56463291600;57215782181;57215781169;23469660300;,China’s local governments are combating COVID-19 with unprecedented responses — from a Wenzhou governance perspective,2020,Frontiers of Medicine,,,,,,,,10.1007/s11684-020-0755-z,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081908667&doi=10.1007%2fs11684-020-0755-z&partnerID=40&md5=f31c5026f73fa3407dca41416aa1d662,"School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, China; Biomedicine Collaborative Innovation Center, Wenzhou, 325035, China; School of Public Health and Management, Wenzhou Medical University, Wenzhou, 325035, China","Gong, F., School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, China, Biomedicine Collaborative Innovation Center, Wenzhou, 325035, China; Xiong, Y., Biomedicine Collaborative Innovation Center, Wenzhou, 325035, China; Xiao, J., School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, China, Biomedicine Collaborative Innovation Center, Wenzhou, 325035, China; Lin, L., School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, China, Biomedicine Collaborative Innovation Center, Wenzhou, 325035, China; Liu, X., School of Public Health and Management, Wenzhou Medical University, Wenzhou, 325035, China; Wang, D., Biomedicine Collaborative Innovation Center, Wenzhou, 325035, China; Li, X., School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, 325035, China, Biomedicine Collaborative Innovation Center, Wenzhou, 325035, China","The COVID-19 caused by a novel strain of Coronavirus has been spreading rapidly since its onset in Wuhan, the capital city of central China’s Hubei Province, in December 2019. It is highly communicable through human-to-human transmission. China has been making unprecedented efforts in treating the confirmed cases, identifying and isolating their close contacts and suspected cases to control the source of infection and cut the route of transmission. China’s devotion in handling this epidemic has effectively and efficiently curbed communication domestically and across the border. Representative measures adopted by Wenzhou, the worst hit city out of Hubei Province, are examined to elucidate those massive undertakings with the aim of enhancing international understanding and building global rapport in fighting this evolving epidemic situation. © 2020, Higher Education Press and Springer-Verlag GmbH Germany, part of Springer Nature.",2019-nCoV; COVID-19; epidemic management; novel coronavirus pneumonia,,"(2020) National Health Commission of the People’s Republic of China. Notice by National Health Commission on the Provisional Designation of Novel Coronavirus Pneumonia, , http://www.nhc.gov.cn/yzygj/s7653p/202002/18c1bb43965a4492907957875de02ae7.shtml, in Chinese, accessed February 8, 2020; (2020) Novel Coronavirus (2019-Ncov) Situation Report - 22, , https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200211-sitrep-22-ncov.pdf?sfvrsn=fb6d49b1_2, accessed February 12, 2020; (2020), https://www.who.int/dg/speeches/detail/who-director-general-s-statement-on-ihr-emergency-committee-on-novel-coronavirus-(2019-ncov), WHO Director-General’s statement on IHR Emergency Committee on Novel Coronavirus (2019-nCoV), accessed February 3, 2020; (2020), http://www.nhc.gov.cn/xcs/yqfkdt/202002/395f075a5f3a4nf30335766c65b0487.shtml, (in Chinese) (accessed February 12, 2020); (2020) Real-Time Update: Latest on COVID-19, , https://news.qq.com/zt2020/page/feiyan.htm, (in Chinese), accessed February 12, 2020; (2020) Makeshift Hospital in Wuhan Receives Coronavirus-Infected Patients, , http://www.xinhuanet.com/english/2020-02/08/c_138766645.htm, accessed February 8, 2020; (2020) Fight Ten Days for the Inflection Point! Wenzhou Sounds the Bugle Call to Beat Epidemic Spread, , http://wjw.wenzhou.gov.cn/art/2020/1/29/art_1209919_41860600.html, in Chinese, accessed February 3, 2020; (2020) Commanding China’s Fight against Novel Coronavirus Outbreak, , https://www.chinadaily.com.cn/a/202002/02/WS5e36ab70a310128217274329.html, accessed February 3, 2020","Li, X.; School of Pharmaceutical Sciences, Wenzhou Medical UniversityChina; email: lixk1964@163.com",,Higher Education Press,20950217,,,,English,Front. Med.,Note,Article in Press,Open Access,Scopus,2-s2.0-85081908667,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Oh S.-H., Lee S.Y., Han C.",55964320000;57215024572;57215026800;,The Effects of Social Media Use on Preventive Behaviors during Infectious Disease Outbreaks: The Mediating Role of Self-relevant Emotions and Public Risk Perception,2020,Health Communication,,,,,,,,10.1080/10410236.2020.1724639,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079706778&doi=10.1080%2f10410236.2020.1724639&partnerID=40&md5=b9684a211bea0eb07c243cb07dde3a8b,"Charles H. Sandage Department of Advertising, College of Media, University of Illinois at Urbana-Champaign, United States; School of Media, Arts, and Science, Sogang University, South Korea","Oh, S.-H., Charles H. Sandage Department of Advertising, College of Media, University of Illinois at Urbana-Champaign, United States; Lee, S.Y., Charles H. Sandage Department of Advertising, College of Media, University of Illinois at Urbana-Champaign, United States; Han, C., School of Media, Arts, and Science, Sogang University, South Korea","While there has been increasing attention to the role of social media during infectious disease outbreaks, relatively little is known about the underlying mechanisms by which social media use affects risk perception and preventive behaviors during such outbreaks. Using data collected during the 2015 Middle East Respiratory Syndrome coronavirus (MERS-CoV) outbreak in South Korea, this study explores the relationships among social media use, risk perception, and preventive behaviors by examining the mediating role of two self-relevant emotions: fear and anger. The findings demonstrate that social media use is positively related to both of these emotions, which are also positively related to the public’s risk perception. The findings also indicate that social media use can significantly increase preventive behaviors via the two self-relevant emotions and the public’s risk perception. © 2020, © 2020 Taylor & Francis Group, LLC.",,,"Ali, K., Zain-ul-abdin, K., Li, C., Johns, L., Ali, A.A., Carcioppolo, N., Virus going viral: Impact of fear-arousing sensationalist social media messages on user engagement (2019) Science Communication, 41 (3), pp. 314-338; Chae, J., Lee, C.-J., The psychological mechanism underlying communication effects on behavioral intention: Focusing on affect and cognition in the cancer context (2019) Communication Research, 46 (5), pp. 597-618; Chan, M.S., Winneg, K., Hawkins, L., Farhadloo, M., Jamieson, K.H., Albarrabcin, D., Legacy and social media respectively influence risk perceptions and protective behaviors during emerging health threats: A multi-wave analysis of communications on Zika virus cases (2018) Social Science & Medicine, 212, pp. 50-59; Choe, S., South Korean hamlet, under MERS quarantine, symbolizes weaknesses in system (2015) The New York Times, , https://www.nytimes.com/2015/06/11/world/asia/south-korean-hamlet-under-mers-quarantine-symbolizes-weaknesses-in-system.html, June, 10, Retrieved from; Choi, D.H., Yoo, W., Noh, G.Y., Park, K., The impact of social media on risk perceptions during the MERS outbreak in South Korea (2017) Computers in Human Behavior, 72, pp. 422-431; Chong, M., Choy, M., The social amplification of haze-related risks on the internet (2018) Health Communication, 33 (1), pp. 14-21; Ding, H., Zhang, J., Social media and participatory risk communication during the H1N1 flu epidemic: A comparative study of the United States and China (2010) China Media Research, 6 (4), pp. 80-91; Do, H.J., Lim, C.G., Kim, Y.J., Choi, H.J., Analyzing emotions in twitter during a crisis: A case study of the 2015 Middle East respiratory syndrome outbreak in Korea (2016) Paper presented at 2016 International Conference on Big Data and Smart Computing (BigComp), , http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=7425960&isnumber=7425793, January, Hong Kong, China: Paper Retrieved from; Dunlop, S., Wakefield, M., Kashima, Y., Can you feel it? 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The influence of discrete emotions on risk perception (2018) Journal of Risk Research, 21 (7), pp. 834-853; Yoo, W., Chio, D., Park, K., The effects of SNS communication: How expressing and receiving information predict MERS-preventive behavioral intentions in South Korea (2016) Computers in Human Behavior, 62, pp. 34-43; Yoo, W., Paek, H.-J., Hove, T., Differential effects of content-oriented versus user-oriented social media on risk perceptions and behavioral intentions (2018) Health Communication, , Advanced online publication; You, M., Joo, J., Park, E., Noh, G.-Y., Ju, Y., Emerging infectious disease content in newspaper editorials: Public health concern or leadership issue? (2017) Science Communication, 39 (3), pp. 313-337","Oh, S.-H.; Charles H. Sandage Department of Advertising, College of Media, University of Illinois at Urbana-Champaign, 119 Gregory Hall, MC 462, United States; email: sanghwa2@illinois.edu",,Routledge,10410236,,,,English,Health Commun.,Article,Article in Press,,Scopus,2-s2.0-85079706778,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Fehr A.R.,36061058900;,Bacterial artificial chromosome-based lambda red recombination with the I-Scei homing endonuclease for genetic alteration of MERS-CoV,2020,Methods in Molecular Biology,2099,,,53,68,,,10.1007/978-1-0716-0211-9_5,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077331703&doi=10.1007%2f978-1-0716-0211-9_5&partnerID=40&md5=a0ea04cfc40258d8da5ae088c5a7317f,"Department of Molecular Biosciences, University of Kansas, Lawrence, KS, United States","Fehr, A.R., Department of Molecular Biosciences, University of Kansas, Lawrence, KS, United States","Over the past two decades, several coronavirus (CoV) infectious clones have been engineered, allowing for the manipulation of their large viral genomes (~30 kb) using unique reverse genetic systems. These reverse genetic systems include targeted recombination, in vitro ligation, vaccinia virus vectors, and bacterial artificial chromosomes (BACs). Quickly after the identification of Middle East respiratory syndrome-CoV (MERS-CoV), both in vitro ligation and BAC-based reverse genetic technologies were engineered for MERS-CoV to study its basic biological properties, develop live-attenuated vaccines, and test antiviral drugs. Here, I will describe how lambda red recombination can be used with the MERS-CoV BAC to quickly and efficiently introduce virtually any type of genetic modification (point mutations, insertions, deletions) into the MERS-CoV genome and recover recombinant virus. © Springer Science+Business Media, LLC, part of Springer Nature 2020.",Bacterial artificial chromosome (BAC); Coronavirus; Infectious clone; Lambda red recombination; MERS-CoV; Reverse genetics,,"Fehr, A.R., Channappanavar, R., Perlman, S., Middle East respiratory syndrome: Emergence of a pathogenic human coronavirus (2017) Annu Rev Med, 68, pp. 387-399. , https://doi.org/10.1146/annurev-med-051215-031152; Almazan, F., Dediego, M.L., Sola, I., Zuniga, S., Nieto-Torres, J.L., Marquez-Jurado, S., Andres, G., Enjuanes, L., Engineering a replication-competent, propagation-defective Middle East respiratory syndrome coronavirus as a vaccine candidate (2013) Mbio, 4 (5), p. e00650. , https://doi.org/10.1128/mBio.00650-13; Scobey, T., Yount, B.L., Sims, A.C., Donaldson, E.F., Agnihothram, S.S., Menachery, V.D., Graham, R.L., Baric, R.S., Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus (2013) Proc Natl Acad Sci U S A, 110 (40), pp. 16157-16162. , https://doi.org/10.1073/pnas.1311542110; Almazan, F., Gonzalez, J.M., Penzes, Z., Izeta, A., Calvo, E., Plana-Duran, J., Enjuanes, L., Engineering the largest RNA virus genome as an infectious bacterial artificial chromosome (2000) Proc Natl Acad Sci U S A, 97 (10), pp. 5516-5521; Yount, B., Denison, M.R., Weiss, S.R., Baric, R.S., Systematic assembly of a full-length infectious cDNA of mouse hepatitis virus strain A59 (2002) J Virol, 76 (21), pp. 11065-11078; Yount, B., Curtis, K.M., Baric, R.S., Strategy for systematic assembly of large RNA and DNA genomes: Transmissible gastroenteritis virus model (2000) J Virol, 74 (22), pp. 10600-10611; Almazan, F., Dediego, M.L., Galan, C., Escors, D., Alvarez, E., Ortego, J., Sola, I., Enjuanes, L., Construction of a severe acute respiratory syndrome coronavirus infectious cDNA clone and a replicon to study coronavirus RNA synthesis (2006) J Virol, 80 (21), pp. 10900-10906. , https://doi.org/10.1128/JVI.00385-06; Balint, A., Farsang, A., Zadori, Z., Hornyak, A., Dencso, L., Almazan, F., Enjuanes, L., Belak, S., Molecular characterization of feline infectious peritonitis virus strain DF-2 and studies of the role of ORF3abc in viral cell tropism (2012) J Virol, 86 (11), pp. 6258-6267. , https://doi.org/10.1128/JVI.00189-12; Fehr, A.R., Athmer, J., Channappanavar, R., Phillips, J.M., Meyerholz, D.K., Perlman, S., The nsp3 macrodomain promotes virulence in mice with coronavirus-induced encephalitis (2015) J Virol, 89 (3), pp. 1523-1536. , https://doi.org/10.1128/JVI.02596-14; St-Jean, J.R., Desforges, M., Almazan, F., Jacomy, H., Enjuanes, L., Talbot, P.J., Recovery of a neurovirulent human coronavirus OC43 from an infectious cDNA clone (2006) J Virol, 80 (7), pp. 3670-3674. , https://doi.org/10.1128/JVI.80.7.3670-3674.2006; Li, J., Jin, Z., Gao, Y., Zhou, L., Ge, X., Guo, X., Han, J., Yang, H., Development of the full-length cDNA clones of two porcine epidemic diarrhea disease virus isolates with different virulence (2017) Plos One, 12 (3). , https://doi.org/10.1371/journal.pone.0173998; Zeng, L.P., Gao, Y.T., Ge, X.Y., Zhang, Q., Peng, C., Yang, X.L., Tan, B., Shi, Z.L., Bat severe acute respiratory syndrome-like coronavirus WIV1 encodes an extra accessory protein, ORFX, involved in modulation of the host immune response (2016) J Virol, 90 (14), pp. 6573-6582. , https://doi.org/10.1128/JVI.03079-15; Murphy, K.C., Use of bacteriophage lambda recombination functions to promote gene replacement in Escherichia coli (1998) J Bacter-Iol, 180 (8), pp. 2063-2071; Oppenheim, A.B., Rattray, A.J., Bubunenko, M., Thomason, L.C., Court, D.L., In vivo recombineering of bacteriophage lambda by PCR fragments and single-strand oligonucleotides (2004) Virology, 319 (2), pp. 185-189. , https://doi.org/10.1016/j.virol.2003.11.007; Lee, E.C., Yu, D., Martinez de Velasco, J., Tessarollo, L., Swing, D.A., Court, D.L., Jenkins, N.A., Copeland, N.G., A highly efficient Escherichia coli-based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNA (2001) Genomics, 73 (1), pp. 56-65. , https://doi.org/10.1006/geno.2000.6451; Zhang, Y., Buchholz, F., Muyrers, J.P., Stewart, A.F., A new logic for DNA engineering using recombination in Escherichia coli (1998) Nat Genet, 20 (2), pp. 123-128. , https://doi.org/10.1038/2417; Warming, S., Costantino, N., Court, D.L., Jenkins, N.A., Copeland, N.G., Simple and highly efficient BAC recombineering using galK selection (2005) Nucleic Acids Res, 33 (4), p. e36. , https://doi.org/10.1093/nar/gni035; Tischer, B.K., von Einem, J., Kaufer, B., Osterrieder, N., Two-step red-mediated recombination for versatile high-efficiency markerless DNA manipulation in Escherichia coli (2006) Bio-Techniques, 40 (2), pp. 191-197; Almazan, F., Marquez-Jurado, S., Nogales, A., Enjuanes, L., Engineering infectious cDNAs of coronavirus as bacterial artificial chromosomes (2015) Methods Mol Biol, 1282, pp. 135-152. , https://doi.org/10.1007/978-1-4939-2438-7_13; Tischer, B.K., Smith, G.A., Osterrieder, N., En passant mutagenesis: A two step markerless red recombination system (2010) Methods Mol Biol, 634, pp. 421-430. , https://doi.org/10.1007/978-1-60761-652-8_30","Fehr, A.R.; Department of Molecular Biosciences, University of KansasUnited States; email: arfehr@ku.edu",,Humana Press Inc.,10643745,,,31883087,English,Methods Mol. Biol.,Book Chapter,Final,Open Access,Scopus,2-s2.0-85077331703,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Jin Y., Yang H., Ji W., Wu W., Chen S., Zhang W., Duan G.",57216037340;15128440500;57216039600;55516553400;56209292200;57216036760;55873071900;,"Virology, epidemiology, pathogenesis, and control of covid-19",2020,Viruses,12,4,372,,,,,10.3390/v12040372,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082528419&doi=10.3390%2fv12040372&partnerID=40&md5=4198d01c38e2ea0db33dd7960b504037,"Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, 450001, China; School of Public Health, Xinxiang Medical University, Xinxiang, 453003, China; Department of Immunology, Duke University Medical Center, Durham, NC 27710, United States","Jin, Y., Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, 450001, China; Yang, H., Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, 450001, China; Ji, W., Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, 450001, China; Wu, W., School of Public Health, Xinxiang Medical University, Xinxiang, 453003, China; Chen, S., Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, 450001, China; Zhang, W., Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, 450001, China, Department of Immunology, Duke University Medical Center, Durham, NC 27710, United States; Duan, G., Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, 450001, China","The outbreak of emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) in China has been brought to global attention and declared a pandemic by the World Health Organization (WHO) on March 11, 2020. Scientific advancements since the pandemic of severe acute respiratory syndrome (SARS) in 2002~2003 and Middle East respiratory syndrome (MERS) in 2012 have accelerated our understanding of the epidemiology and pathogenesis of SARS-CoV-2 and the development of therapeutics to treat viral infection. As no specific therapeutics and vaccines are available for disease control, the epidemic of COVID-19 is posing a great threat for global public health. To provide a comprehensive summary to public health authorities and potential readers worldwide, we detail the present understanding of COVID-19 and introduce the current state of development of measures in this review. © 2020 by the authors.",COVID-19; Epidemiology; Pathogenesis; SARS-CoV-2; Therapeutics,,"Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Ren, R., Wong, J.Y., Early transmission dynamics in Wuhan, China, of novel coronavirus–infected pneumonia (2020) N.Engl. J. 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Med.; Sun, C., Chen, L., Yang, J., Luo, C., Zhang, Y., Li, J., Yang, J., Xie, L., SARS-CoV-2 and SARS-CoV spike-RBD structure and receptor binding comparison and potential implications on neutralizing antibody and vaccine development (2020) bioRxiv; Abdelmageed, M.I., Abdelmoneim, A.H., Mustafa, M.I., Elfadol, N.M., Murshed, N.S., Shantier, S.W., Makhawi, A.M., Design of multi epitope-based peptide vaccine against E protein of human 2019-nCoV: An immunoinformatics approach (2020) bioRxiv; NhuThao, T.T., Labroussaa, F., Ebert, N., V’kovski, P., Stalder, H., Portmann, J., Kelly, J., Kratzel, A., Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform (2020) bioRxiv; Bao, L., Deng, W., Huang, B., Gao, H., Liu, J., Ren, L., Wei, Q., Qi, F., The pathogenicity of SARS-CoV-2 in HACE2 transgenic mice (2020) bioRxiv; (2020) The Military Successfully Developed A Recombinant SARS-CoV-2 Vaccine, , http://www.mod.gov.cn/topnews/2020-03/17/content_4862066.htm, Ministry of National Defense of the People’s Republic of China 17 March; (2020) American Moderna Vaccine Enters Clinical Trial, , https://www.modernatx.com/modernas-work-potential-vaccine-against-covid-19, 23 March","Duan, G.; Department of Epidemiology, College of Public Health, Zhengzhou UniversityChina; email: gcduan@zzu.edu.cn",,MDPI AG,19994915,,,,English,Viruses,Review,Final,Open Access,Scopus,2-s2.0-85082528419,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Li Y., Guo F., Cao Y., Li L., Guo Y.",57215824813;57215813826;57215823772;57215818803;57208256602;,Insight into COVID-2019 for pediatricians,2020,Pediatric Pulmonology,,,,,,,,10.1002/ppul.24734,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081971295&doi=10.1002%2fppul.24734&partnerID=40&md5=5b3ddf96b7b8a7f9f6fff190a41af477,"Department of Pediatrics, Children's Hospital Affiliated of Zhengzhou University, Zhengzhou, China; Department of Pediatrics, The First people's Hospital of Yunnan Province, Kunming, China; Department of Pediatrics, Zhengzhou General Hospital, Zhengzhou, China; National Engineering Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China","Li, Y., Department of Pediatrics, Children's Hospital Affiliated of Zhengzhou University, Zhengzhou, China; Guo, F., Department of Pediatrics, The First people's Hospital of Yunnan Province, Kunming, China; Cao, Y., Department of Pediatrics, Zhengzhou General Hospital, Zhengzhou, China; Li, L., National Engineering Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Guo, Y., Department of Pediatrics, Children's Hospital Affiliated of Zhengzhou University, Zhengzhou, China","Since December 2019, patients with unexplained pneumonia have been found in Wuhan City, Hubei Province, China. The pathogen in these cases is a new type of coronavirus. The World Health Organization confirmed this diagnosis and named the pathogen SARSCoV-2. The disease caused by SARSCoV-2 is called Corona Virus Disease (COVID-2019). The virus is highly infectious and pathogenic, causing human-to-human transmission. At present, SARSCoV-2 is still rampant in the world. Zhengzhou City in Henan Province serves as an example, 102 people have been confirmed to be infected with SARSCoV-2 (at 24:00 on February 5th, 2020), including three children, the youngest is 4 years old. From the perspective of clinical pediatricians as the first line fighting the epidemic, this paper will discuss the clinical characteristics, prevention and control measures, outcomes, diagnosis, and treatment of pediatric cases. © 2020 Wiley Periodicals, Inc.",COVID-2019; pediatric infection; SARSCoV-2,,"Rothe, C., Schunk, M., Sothmann, P., Transmission of 2019-nCoV infection from an asymptomatic contact in Germany (2020) N Engl J Med, 382, pp. 970-971. , https://doi.org/10.1056/NEJMc2001468; Epidemic situation of novel coronavirus pneumonia at 24:00 on February 5th, , http://www.hnwsjsw.gov.cn/contents/854/48152.shtml, Accessed February 5; http://www.nhc.gov.cn/xcs/yqtb/202002/6b1e029fd22c484281cbc5e73dae98fc.shtml, Epidemic situation of novel coronavirus pneumonia at 2400 on February 5th., Accessed February 5; Jiang, Y., Xu, B.P., Jin, R.M., Expert consensus on diagnosis, treatment and prevention of novel coronavirus infection in pediatrics (the first edition) [standard programme guidline] (2020) Chin J Appl Clin Pediatr, 35 (2), pp. 81-85. , https://doi.org/10.3760/cma.j.issn.2095-428X.2020.02.001; Fang, F., Luo, X.P., Facing 2019 novel coronavirus infections: a pediatrician's thinking (2020) Chin J Pediatr, 58 (2), pp. 81-85. , https://doi.org/10.3760/cma.j.issn.0578-1310.2020.02.001; Cai, J.H., Wang, X., Ge, Y.L., The first case of novel coronavirus infection in children in Shanghai (2020) Chin J Pediatr, 58, pp. 86-87. , https://doi.org/10.3760/cma.j.issn.0578-1310.2020.0002; Chan, J.F.W., Yuan, S., Kok, K.H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster[J] (2020) Lancet, 395 (10223), pp. 514-523. , https://doi.org/10.1016/S0140-6736(20)30154-9, Accessed February 5; Deng, H., Zhang, Y., Wang, Y., Novel coronavirus infection in children: a report of two cases (2020) Chin Pediatr Emerg Med, 27 (2), pp. 81-83; Kuhn, J.H., Li, W., Choe, H., Farzan, M., Angiotensin-converting enzyme 2: a functional receptor for SARS coronavirus (2004) Cell Mol Life Sci, 61, pp. 2738-2743. , https://doi.org/10.1007/s00018-004-4242-5; Zhou, P., Yang, X.-L., Wang, X.-G., Discovery of a novel coronavirus associated with the recent pneumonia outbreak in 3 humans and its potential bat origin (2020) bioRxiv, , https://doi.org/10.1101/2020.01.22.914952; Zhao, Y., Zhao, Z., Wang, Y., Single-cell RNA expression profiling of ACE2, the putative receptor of Wuhan 2019-nCov (2020) bioRxiv, , https://doi.org/10.1101/2020.01.26.919985; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395, pp. 507-513. , https://doi.org/10.1016/S0140-6736(20)30211-7; Chai, X., Longfei, H., Yan, Z., Specific ACE2 expression in cholangiocytes may cause liver damage after 2019-nCoV infection (2020) bioRxiv, , https://doi.org/10.1101/2020.02.03.931766","Guo, Y.; Department of Pediatrics, Children's Hospital Affiliated of Zhengzhou UniversityChina; email: 2289679861@qq.com",,John Wiley and Sons Inc.,87556863,,PEPUE,,English,Pediatr. Pulmonol.,Article,Article in Press,Open Access,Scopus,2-s2.0-85081971295,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Lai A., Bergna A., Acciarri C., Galli M., Zehender G.",25229058300;57204488072;57215504977;57209815458;7004294030;,Early phylogenetic estimate of the effective reproduction number of SARS-CoV-2,2020,Journal of Medical Virology,,,,,,,1,10.1002/jmv.25723,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081007711&doi=10.1002%2fjmv.25723&partnerID=40&md5=500da161833ea0958f5233de35477ba2,"Department of Biomedical and Clinical Sciences ""L. Sacco"", University of Milan, Milano, Italy; Coordinated Research Center ""EpiSoMI"", University of Milan, Milano, Italy; Romeo ed Enrica Invernizzi Pediatric Research Center, University of Milan, Milano, Italy","Lai, A., Department of Biomedical and Clinical Sciences ""L. Sacco"", University of Milan, Milano, Italy, Coordinated Research Center ""EpiSoMI"", University of Milan, Milano, Italy; Bergna, A., Department of Biomedical and Clinical Sciences ""L. Sacco"", University of Milan, Milano, Italy; Acciarri, C., Department of Biomedical and Clinical Sciences ""L. Sacco"", University of Milan, Milano, Italy; Galli, M., Department of Biomedical and Clinical Sciences ""L. Sacco"", University of Milan, Milano, Italy, Coordinated Research Center ""EpiSoMI"", University of Milan, Milano, Italy; Zehender, G., Department of Biomedical and Clinical Sciences ""L. Sacco"", University of Milan, Milano, Italy, Coordinated Research Center ""EpiSoMI"", University of Milan, Milano, Italy, Romeo ed Enrica Invernizzi Pediatric Research Center, University of Milan, Milano, Italy","To reconstruct the evolutionary dynamics of the 2019 novel-coronavirus recently causing an outbreak in Wuhan, China, 52 SARS-CoV-2 genomes available on 4 February 2020 at Global Initiative on Sharing All Influenza Data were analyzed. The two models used to estimate the reproduction number (coalescent-based exponential growth and a birth-death skyline method) indicated an estimated mean evolutionary rate of 7.8 × 10−4 subs/site/year (range, 1.1 × 10−4-15 × 10−4) and a mean tMRCA of the tree root of 73 days. The estimated R value was 2.6 (range, 2.1-5.1), and increased from 0.8 to 2.4 in December 2019. The estimated mean doubling time of the epidemic was between 3.6 and 4.1 days. This study proves the usefulness of phylogeny in supporting the surveillance of emerging new infections even as the epidemic is growing. © 2020 Wiley Periodicals, Inc.",evolutionary dynamics; reproductive number; SARS-CoV-2,,"Lu, R., Zhao, X., Li, J., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet, 395, pp. 565-574; Paraskevis, D., Kostaki, E.G., Magiorkinis, G., Panayiotakopoulos, G., Sourvinos, G., Tsiodras, S., Full-genome evolutionary analysis of the novel corona virus (2019-nCoV) rejects the hypothesis of emergence as a result of a recent recombination event (2020) Infect Genet Evol, 79; Zhou, P., Yang, X.-L., Wang, X.-G., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature, , https://doi.org/10.1038/s41586-020-2012-7; Posada, D., jModelTest: phylogenetic model averaging (2008) Mol Biol Evol, 25 (7), pp. 1253-1256; Drummond, A.J., Suchard, M.A., Xie, D., Rambaut, A., Bayesian phylogenetics with BEAUti and the BEAST 1.7 (2012) Mol Biol Evol, 29 (8), pp. 1969-1973; Suchard, M.A., Weiss, R.E., Sinsheimer, J.S., Bayesian selection of continuous-time Markov chain evolutionary models (2001) Mol Biol Evol, 18 (6), pp. 1001-1013; Baele, G., Lemey, P., Bedford, T., Rambaut, A., Suchard, M.A., Alekseyenko, A.V., Improving the accuracy of demographic and molecular clock model comparison while accommodating phylogenetic uncertainty (2012) Mol Biol Evol, 29 (9), pp. 2157-2167; Pybus, O.G., Charleston, M.A., Gupta, S., Rambaut, A., Holmes, E.C., Harvey, P.H., The epidemic behavior of the hepatitis C virus (2001) Science, 292 (5525), pp. 2323-2325; Stadler, T., Kuhnert, D., Bonhoeffer, S., Drummond, A.J., Birth-death skyline plot reveals temporal changes of epidemic spread in HIV and hepatitis C virus (HCV) (2013) Proc Natl Acad Sci U S A, 110 (1), pp. 228-233; Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med; Walker, P.R., Pybus, O.G., Rambaut, A., Holmes, E.C., Comparative population dynamics of HIV-1 subtypes B and C: subtype-specific differences in patterns of epidemic growth (2005) Infect Genet Evol, 5 (3), pp. 199-208; Lipsitch, M., Transmission dynamics and control of severe acute respiratory syndrome (2003) Science, 300 (5627), pp. 1966-1970; Assiri, A., McGeer, A., Perl, T.M., Hospital outbreak of Middle East respiratory syndrome coronavirus (2013) N Engl J Med, 369 (5), pp. 407-416; Liu, T., Hu, J., Kang, M., Transmission dynamics of 2019 novel coronavirus (2019-nCoV) (2020) bioRxiv, 2020 (2001), p. 2025; Veo, C., Della Ventura, C., Moreno, A., Evolutionary dynamics of the lineage 2 West Nile virus that caused the largest European epidemic: Italy 2011-2018 (2019) Viruses, 11 (9), p. 814; Towers, S., Patterson-Lomba, O., Castillo-Chavez, C., Temporal variations in the effective reproduction number of the 2014 west Africa ebola outbreak (2014) PLoS Currents, 6. , https://doi.org/10.1371/currents.outbreaks.9e4c4294ec8ce1adad283172b16bc908; Zhao, S., Musa, S.S., Lin, Q., Estimating the unreported number of novel coronavirus (2019-nCoV) cases in China in the first half of January 2020: a data-driven modelling analysis of the early outbreak (2020) J Clin Med, 9 (2), p. 388; Zhao, S., Lin, Q., Ran, J., Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: a data-driven analysis in the early phase of the outbreak (2020) Int J Infect Dis, 92, pp. 214-217","Zehender, G.; Department of Biomedical and Clinical Sciences ""L. Sacco"", University of MilanItaly; email: gianguglielmo.zehender@unimi.it",,John Wiley and Sons Inc.,1466615,,JMVID,32096566,English,J. Med. Virol.,Article,Article in Press,Open Access,Scopus,2-s2.0-85081007711,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "French M., Monahan T.",15839468100;57206303026;,Disease surveillance: how might surveillance studies address covid-19?,2020,Surveillance and Society,18,1,,1,11,,,10.24908/ss.v18i1.13985,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082177573&doi=10.24908%2fss.v18i1.13985&partnerID=40&md5=fe66b6374d2d42ad88d03a9214aa1890,"Concordia University, Canada; University of North Carolina at Chapel Hill, United States","French, M., Concordia University, Canada; Monahan, T., University of North Carolina at Chapel Hill, United States","We are currently in the midst of a global pandemic with the spread of Coronavirus Disease 2019 (COVID-19). While we do not know how this situation will unfold or resolve, we do have insight into how it fits within existing patterns and relations, particularly those pertaining to sociocultural constructions of (in)security, vulnerability, and risk. We can see evidence of surveillance dynamics at play with how bodies and pathogens are being measured, tracked, predicted, and regulated. We can grasp how threat is being racialized, how and why institutions are flailing, and how social media might be fueling social divisions. There is, in other words, a lot that our scholarly community could add to the conversation. In this rapid-response editorial, we provide an introduction to the framing devices of disease surveillance and discuss how a surveillance studies orientation could help us think critically about the present crisis and its possible aftermath. © The author(s), 2020.",,,"Aas, K.F., “Crimmigrant” Bodies and Bona Fide Travelers: Surveillance, Citizenship and Global Governance (2011) Theoretical Criminology, 15 (3), pp. 331-346; Nurhan, A., Surveillance and Spatial Flows in the Occupied Palestinian Territories (2010) Surveillance and Control in Israel/Palestine, pp. 313-334. , E. Zureik, D. Lyon, and Y. 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Soc.,Article,Final,Open Access,Scopus,2-s2.0-85082177573,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Boley P.A., Alhamo M.A., Lossie G., Yadav K.K., Vasquez-Lee M., Saif L.J., Kenney S.P.",57205406848;57192310594;57214084317;57214074354;13410248100;57205309530;21934200600;,"Porcine deltacoronavirus infection and transmission in poultry, United States",2020,Emerging Infectious Diseases,26,2,,255,264,,,10.3201/eid2602.190346,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078115968&doi=10.3201%2feid2602.190346&partnerID=40&md5=b3f5d8d5f756a38ab0c057dfd68ee673,"Ohio State University, Wooster, OH, United States; Ohio State University, Columbus, OH, United States","Boley, P.A., Ohio State University, Wooster, OH, United States; Alhamo, M.A., Ohio State University, Wooster, OH, United States; Lossie, G., Ohio State University, Columbus, OH, United States; Yadav, K.K., Ohio State University, Wooster, OH, United States; Vasquez-Lee, M., Ohio State University, Wooster, OH, United States; Saif, L.J., Ohio State University, Wooster, OH, United States; Kenney, S.P., Ohio State University, Wooster, OH, United States","Coronaviruses cause respiratory and gastrointestinal diseases in diverse host species. Deltacoronaviruses (DCoVs) have been identified in various songbird species and in leopard cats in China. In 2009, porcine deltacoronavirus (PDCoV) was detected in fecal samples from pigs in Asia, but its etiologic role was not identified until 2014, when it caused major diarrhea outbreaks in swine in the United States. Studies have shown that PDCoV uses a conserved region of the aminopeptidase N protein to infect cell lines derived from multiple species, including humans, pigs, and chickens. Because PDCoV is a potential zoonotic pathogen, investigations of its prevalence in humans and its contribution to human disease continue. We report experimental PDCoV infection and subsequent transmission among poultry. In PDCoV-inoculated chicks and turkey poults, we observed diarrhea, persistent viral RNA titers from cloacal and tracheal samples, PDCoV-specific serum IgY antibody responses, and antigen-positive cells from intestines. © 2020 Centers for Disease Control and Prevention (CDC). 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Geoghegan, J.L., Duchêne, S., Holmes, E.C., Comparative analysis estimates the relative frequencies of co-divergence and cross-species transmission within viral families (2017) PLoS Pathog, 13, p. e1006215; Ismail, M.M., Tang, A.Y., Saif, Y.M., Pathogenicity of Turkey coronavirus in Turkeys and chickens (2003) Avian Dis, 47, pp. 515-522; Ismail, M.M., Cho, K.O., Ward, L.A., Saif, L.J., Saif, Y.M., Experimental bovine coronavirus in Turkey poults and young chickens (2001) Avian Dis, 45, pp. 157-163; Hu, H., Jung, K., Vlasova, A.N., Chepngeno, J., Lu, Z., Wang, Q., Isolation and characterization of porcine deltacoronavirus from pigs with diarrhea in the United States (2015) J Clin Microbiol, 53, pp. 1537-1548; Reed, L.J., Muench, H., A simple method of estimating fifty percent endpoints (1938) Am J Epidemiol, 37, pp. 493-497; Jung, K., Miyazaki, A., Hu, H., Saif, L.J., Susceptibility of porcine IPEC-J2 intestinal epithelial cells to infection with porcine deltacoronavirus (PDCoV) and serum cytokine responses of gnotobiotic pigs to acute infection with IPEC-J2 cell culture-passaged PDCoV (2018) Vet Microbiol, 221, pp. 49-58; Hu, H., Jung, K., Vlasova, A.N., Saif, L.J., Experimental infection of gnotobiotic pigs with the cell-culture-adapted porcine deltacoronavirus strain OH-FD22 (2016) Arch Virol, 161, pp. 3421-3434; Jung, K., Kim, J., Ha, Y., Choi, C., Chae, C., The effects of transplacental porcine circovirus type 2 infection on porcine epidemic diarrhoea virus-induced enteritis in preweaning piglets (2006) Vet J, 171, pp. 445-450; Okda, F., Lawson, S., Liu, X., Singrey, A., Clement, T., Hain, K., Development of monoclonal antibodies and serological assays including indirect ELISA and fluorescent microsphere immunoassays for diagnosis of porcine deltacoronavirus (2016) BMC Vet Res, 12, p. 95; Vlasova, A.N., Saif, L.J., Biological aspects of the interspecies transmission of selected coronaviruses (2013) Viral Infections and Global Change, pp. 393-418. , In: Singh SK, editor., Hoboken (NJ): John Wiley & Sons; Ji, C.M., Wang, B., Zhou, J., Huang, Y.W., Aminopeptidase-N-independent entry of porcine epidemic diarrhea virus into Vero or porcine small intestine epithelial cells (2018) Virology, 517, pp. 16-23; Mina-Osorio, P., The moonlighting enzyme CD13: Old and new functions to target (2008) Trends Mol Med, 14, pp. 361-371; Van Der Velden, V.H., Wierenga-Wolf, A.F., Adriaansen-Soeting, P.W., Overbeek, S.E., Möller, G.M., Hoogsteden, H.C., Expression of aminopeptidase N and dipeptidyl peptidase IV in the healthy and asthmatic bronchus (1998) Clin Exp Allergy, 28, pp. 110-120; Dijkman, R., Jebbink, M.F., Koekkoek, S.M., Deijs, M., Jónsdóttir, H.R., Molenkamp, R., Isolation and characterization of current human coronavirus strains in primary human epithelial cell cultures reveal differences in target cell tropism (2013) J Virol, 87, pp. 6081-6090; Kenny, A.J., Maroux, S., Topology of microvillar membrance hydrolases of kidney and intestine (1982) Physiol Rev, 62, pp. 91-128; Wang, B., Liu, Y., Ji, C.M., Yang, Y.L., Liang, Q.Z., Zhao, P., Porcine deltacoronavirus engages the transmissible gastroenteritis virus functional receptor porcine aminopeptidase N for infectious cellular entry (2018) J Virol, 92, pp. e00318-e00418; Liang, Q., Zhang, H., Li, B., Ding, Q., Wang, Y., Gao, W., Susceptibility of chickens to porcine deltacoronavirus infection (2019) Viruses, 11, p. E573; Wang, Q., Vlasova, A.N., Kenney, S.P., Saif, L.J., Emerging and re-emerging coronaviruses in pigs (2019) Curr Opin Virol, 34, pp. 39-49; Chen, Q., Wang, L., Yang, C., Zheng, Y., Gauger, P.C., Anderson, T., The emergence of novel sparrow deltacoronaviruses in the United States more closely related to porcine deltacoronaviruses than sparrow deltacoronavirus HKU17 (2018) Emerg Microbes Infect, 7, p. 105; Hu, H., Jung, K., Wang, Q., Saif, L.J., Vlasova, A.N., Development of a one-step RT-PCR assay for detection of pancoronaviruses (α-, β-, γ-, and δ-coronaviruses) using newly designed degenerate primers for porcine and avian 'fecal samples (2018) J Virol Methods, 256, pp. 116-122; Dong, B.Q., Liu, W., Fan, X.H., Vijaykrishna, D., Tang, X.C., Gao, F., Detection of a novel and highly divergent coronavirus from Asian leopard cats and Chinese ferret badgers in southern China (2007) J Virol, 81, pp. 6920-6926; Jung, K., Hu, H., Saif, L.J., Calves are susceptible to infection with the newly emerged porcine deltacoronavirus, but not with the swine enteric alphacoronavirus, porcine epidemic diarrhea virus (2017) Arch Virol, 162, pp. 2357-2362","Kenney, S.P.; Ohio State University, Food Animal Health Research Program, 1680 Madison Ave, United States; email: kenney.157@osu.edu",,Centers for Disease Control and Prevention (CDC),10806040,,EIDIF,31961296,English,Emerg. Infect. Dis.,Article,Final,Open Access,Scopus,2-s2.0-85078115968,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Noh J.-W., Yoo K.-B., Kwon Y.D., Hong J.H., Lee Y., Park K.",54384018600;55754867000;57211434080;57190579239;57196147985;57207108806;,Effect of information disclosure policy on control of infectious disease: MERS-CoV outbreak in South Korea,2020,International Journal of Environmental Research and Public Health,17,1,305,,,,1,10.3390/ijerph17010305,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077531453&doi=10.3390%2fijerph17010305&partnerID=40&md5=54b1ed577abafa8f18720e37ca62b327,"Department of Health Administration, College of Health Science, Dankook University, Cheonan, 31116, South Korea; Department of Health Sciences, Global Health, University Medical Centre Groningen/University of Groningen, Groningen, 9713 GZ, Netherlands; Department of Health Administration, College of Health Sciences, Yonsei University, Wonju, 26493, South Korea; Department of Humanities and Social Medicine, College of Medicine and Catholic Institute for Healthcare Management, The Catholic University of Korea, Seoul, 06591, South Korea; Department of Biostatistics, Korea University College of Medicine, Seoul, 02841, South Korea; Department of Healthcare Management, Eulji University, Seongnam, 13135, South Korea; Institute for Occupational & Environmental Health, Korea University College of Medicine, Seoul, 02841, South Korea","Noh, J.-W., Department of Health Administration, College of Health Science, Dankook University, Cheonan, 31116, South Korea, Department of Health Sciences, Global Health, University Medical Centre Groningen/University of Groningen, Groningen, 9713 GZ, Netherlands; Yoo, K.-B., Department of Health Administration, College of Health Sciences, Yonsei University, Wonju, 26493, South Korea; Kwon, Y.D., Department of Humanities and Social Medicine, College of Medicine and Catholic Institute for Healthcare Management, The Catholic University of Korea, Seoul, 06591, South Korea; Hong, J.H., Department of Biostatistics, Korea University College of Medicine, Seoul, 02841, South Korea; Lee, Y., Department of Healthcare Management, Eulji University, Seongnam, 13135, South Korea; Park, K., Institute for Occupational & Environmental Health, Korea University College of Medicine, Seoul, 02841, South Korea","This study examined the effect of disclosing a list of hospitals with Middle East respiratory syndrome coronavirus (MERS-CoV) patients on the number of laboratory-confirmed MERS-CoV cases in South Korea. MERS-CoV data from 20 May 2015 to 5 July 2015 were from the Korean Ministry of Health & Welfare website and analyzed using segmented linear autoregressive error models for interrupted time series. This study showed that the number of laboratory-confirmed cases was increased by 14.629 on June 5 (p < 0.001). However, this number was significantly decreased following disclosure of a list of hospitals with MERS-CoV cases (Estimate = −0.948; p < 0.001). Disclosing the list of hospitals exposed to MERS-CoV was critical to the prevention of further infection. It reduced the number of confirmed MERS-CoV cases. Thus, providing accurate and timely information is a key to critical care response. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.",Infectious disease; Information disclosure policy; MERS-CoV; Middle East respiratory syndrome; Prevention,disease control; disease spread; health policy; hospital sector; infectious disease; respiratory disease; Article; clinical article; clinical practice; controlled study; disease association; disease control; epidemic; health care facility; health care policy; human; incidence; infection control; information dissemination; information processing; institutional review; intensive care; interpersonal communication; Middle East respiratory syndrome; practice guideline; quasi experimental study; social welfare; South Korea; World Health Organization; South Korea; Coronavirus,"Cowling, B.J., Park, M., Fang, V.J., Wu, P., Leung, G.M., Wu, J.T., Preliminary epidemiologic assessment of MERS-CoV outbreak in South Korea, May–June 2015 (2015) Eur. Surveill., 20, pp. 7-13; Lee, K.-M., (2015) MERS Inflicts Financial Loss to Hospitals, , http://www.koreatimes.co.kr/www/news/nation/2015/06/116_181454.html, The Korean Times: Seoul, Korea, accessed on 12 August 2019; (2015) Organization for Economic Co-Operation and Development (OECD); OECD, , Paris, France; Hui, D.S., Perlman, S., Zumla, A., Spread of MERS to South Korea and China (2015) Lancet Respir. Med., 3, pp. 509-510; Moran, K., 2015 MERS outbreak in Korea: Hospital-to-hospital transmission (2015) Epidemiol. Health, 37; Fung, I.C.-H., Tse, Z.T.H., Chan, B.S.B., Fu, K.-W., Middle East respiratory syndrome in the Republic of Korea: Transparency and communication are key (2015) West. Pac. Surveill. Response J., 6, p. 1; Assiri, A., McGeer, A., Perl, T.M., Price, C.S., Al Rabeeah, A.A., Cummings, D.A., Alabdullatif, Z.N., Makhdoom, H., Hospital outbreak of Middle East respiratory syndrome coronavirus (2013) N. Engl. J. Med., 369, pp. 407-416; Shin, J.-H., (2015) Korea Mulling Disclosure of Mers-Affected Hospitals, , http://www.koreaherald.com/view.php?ud=20150602001071, The Korean Herald: Seoul, Korea; (2019), https://www.mohw.go.kr/eng/nw/nw0101vw.jsp?PAR_MENU_ID=1007&MENU_ID=100701&page=1&CONT_SEQ=323817&SEARCHKEY=TITLE&SEARCHVALUE=June%2027, Ministry of Health & Welfare. Press Release Summary (27 June); (2019) Ministry of Health & Welfare. Middle East Respiratory Syndrome Information, p. 27. , www.mers.go.kr, accessed on, August; Zhang, F., Wagner, A.K., Soumerai, S.B., Ross-Degnan, D., Methods for estimating confidence intervals in interrupted time series analyses of health interventions (2009) J. Clin. Epidemiol., 62, pp. 143-148; Wagner, A.K., Soumerai, S.B., Zhang, F., Ross-Degnan, D., Segmented regression analysis of interrupted time series studies in medication use research (2002) J. Clin. Pharm. Ther., 27, pp. 299-309; Naylor, C.D., Chantler, C., Griffiths, S., Learning from SARS in Hong Kong and Toronto (2004) JAMA, 291, pp. 2483-2487; Choi, J.S., Kim, K.M., Crisis prevention and management by infection control nurses during the Middle East respiratory coronavirus outbreak in Korea (2016) Am. J. Infect. Control., 44, pp. 480-481; Nature Editorial. Realistic risks (2015) Nature, 523, p. 502; Verma, S., Mythily, S., Chan, Y., Deslypere, J., Teo, E., Chong, S., Post-SARS psychological morbidity and stigma among general practitioners and traditional Chinese medicine practitioners in Singapore (2004) Ann. Acad. Med. Singap., 33, pp. 743-748","Park, K.; Institute for Occupational & Environmental Health, Korea University College of MedicineSouth Korea; email: blesspark@naver.com",,MDPI AG,16617827,,,31906369,English,Int. J. Environ. Res. Public Health,Article,Final,Open Access,Scopus,2-s2.0-85077531453,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhou F., Yu T., Du R., Fan G., Liu Y., Liu Z., Xiang J., Wang Y., Song B., Gu X., Guan L., Wei Y., Li H., Wu X., Xu J., Tu S., Zhang Y., Chen H., Cao B.",57215778305;57214909863;57214933480;57201116770;57214466689;57215773217;57215778785;57200608527;57215780499;57214399398;57215770770;57214467086;57195614811;57215781236;57215364706;57215774553;57215782325;57215774276;26022302100;,"Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study",2020,The Lancet,,,,,,,7,10.1016/S0140-6736(20)30566-3,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081901579&doi=10.1016%2fS0140-6736%2820%2930566-3&partnerID=40&md5=60b48cc828061e7b65a326e43414171d,"Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China; Department of Tuberculosis and Respiratory Disease, Jinyintan Hospital, Wuhan, China; Department of Clinical Laboratory, Jinyintan Hospital, Wuhan, China; GCP Center, Jinyintan Hospital, Wuhan, China; Department of Pulmonary and Critical Care Medicine, Wuhan Pulmonary Hospital, Wuhan, China; Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, China; Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China; Department of Respiratory Medicine, Capital Medical University, Beijing, China; Tsinghua University School of Medicine, Beijing, China","Zhou, F., Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China; Yu, T., Department of Tuberculosis and Respiratory Disease, Jinyintan Hospital, Wuhan, China; Du, R., Department of Pulmonary and Critical Care Medicine, Wuhan Pulmonary Hospital, Wuhan, China; Fan, G., Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China; Liu, Y., Department of Tuberculosis and Respiratory Disease, Jinyintan Hospital, Wuhan, China; Liu, Z., Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China; Xiang, J., Department of Clinical Laboratory, Jinyintan Hospital, Wuhan, China; Wang, Y., Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China, Department of Respiratory Medicine, Capital Medical University, Beijing, China; Song, B., Department of Tuberculosis and Respiratory Disease, Jinyintan Hospital, Wuhan, China; Gu, X., Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China; Guan, L., Department of Pulmonary and Critical Care Medicine, Wuhan Pulmonary Hospital, Wuhan, China; Wei, Y., Department of Tuberculosis and Respiratory Disease, Jinyintan Hospital, Wuhan, China; Li, H., Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China; Wu, X., GCP Center, Jinyintan Hospital, Wuhan, China; Xu, J., Tsinghua University School of Medicine, Beijing, China; Tu, S., Department of Tuberculosis and Respiratory Disease, Jinyintan Hospital, Wuhan, China; Zhang, Y., Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China; Chen, H., Department of Tuberculosis and Respiratory Disease, Jinyintan Hospital, Wuhan, China; Cao, B., Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China, Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, China, Department of Respiratory Medicine, Capital Medical University, Beijing, China, Tsinghua University School of Medicine, Beijing, China","Background: Since December, 2019, Wuhan, China, has experienced an outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Epidemiological and clinical characteristics of patients with COVID-19 have been reported but risk factors for mortality and a detailed clinical course of illness, including viral shedding, have not been well described. Methods: In this retrospective, multicentre cohort study, we included all adult inpatients (≥18 years old) with laboratory-confirmed COVID-19 from Jinyintan Hospital and Wuhan Pulmonary Hospital (Wuhan, China) who had been discharged or had died by Jan 31, 2020. Demographic, clinical, treatment, and laboratory data, including serial samples for viral RNA detection, were extracted from electronic medical records and compared between survivors and non-survivors. We used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death. Findings: 191 patients (135 from Jinyintan Hospital and 56 from Wuhan Pulmonary Hospital) were included in this study, of whom 137 were discharged and 54 died in hospital. 91 (48%) patients had a comorbidity, with hypertension being the most common (58 [30%] patients), followed by diabetes (36 [19%] patients) and coronary heart disease (15 [8%] patients). Multivariable regression showed increasing odds of in-hospital death associated with older age (odds ratio 1·10, 95% CI 1·03–1·17, per year increase; p=0·0043), higher Sequential Organ Failure Assessment (SOFA) score (5·65, 2·61–12·23; p<0·0001), and d-dimer greater than 1 μg/mL (18·42, 2·64–128·55; p=0·0033) on admission. Median duration of viral shedding was 20·0 days (IQR 17·0–24·0) in survivors, but SARS-CoV-2 was detectable until death in non-survivors. The longest observed duration of viral shedding in survivors was 37 days. Interpretation: The potential risk factors of older age, high SOFA score, and d-dimer greater than 1 μg/mL could help clinicians to identify patients with poor prognosis at an early stage. Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future. Funding: Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences; National Science Grant for Distinguished Young Scholars; National Key Research and Development Program of China; The Beijing Science and Technology Project; and Major Projects of National Science and Technology on New Drug Creation and Development. © 2020 Elsevier Ltd",,,"Phelan, A.L., Katz, R., Gostin, L.O., The novel coronavirus originating in Wuhan, China: challenges for global health governance (2020) JAMA, , published online Jan 30; Gorbalenya, A.E., Baker, S.C., Baric, R.S., Severe acute respiratory syndrome-related coronavirus: the species and its viruses—a statement of the Coronavirus Study Group (2020) bioRxiv, , published online Feb 11. 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Corrales-Medina, V.F., Musher, D.M., Shachkina, S., Chirinos, J.A., Acute pneumonia and the cardiovascular system (2013) Lancet, 381, pp. 496-505; Udell, J.A., Zawi, R., Bhatt, D.L., Association between influenza vaccination and cardiovascular outcomes in high-risk patients: a meta-analysis (2013) JAMA, 310, pp. 1711-1720; Blackburn, R., Zhao, H., Pebody, R., Hayward, A., Warren-Gash, C., Laboratory-confirmed respiratory infections as predictors of hospital admission for myocardial infarction and stroke: time-series analysis of English data for 2004–2015 (2018) Clin Infect Dis, 67, pp. 8-17; Milbrandt, E.B., Reade, M.C., Lee, M., Prevalence and significance of coagulation abnormalities in community-acquired pneumonia (2009) Mol Med, 15, pp. 438-445; Rodelo, J.R., De la Rosa, G., Valencia, M.L., D-dimer is a significant prognostic factor in patients with suspected infection and sepsis (2012) Am J Emerg Med, 30, pp. 1991-1999; Smeeth, L., Thomas, S.L., Hall, A.J., Hubbard, R., Farrington, P., Vallance, P., Risk of myocardial infarction and stroke after acute infection or vaccination (2004) N Engl J Med, 351, pp. 2611-2618; Corrales-Medina, V.F., Musher, D.M., Wells, G.A., Chirinos, J.A., Chen, L., Fine, M.J., Cardiac complications in patients with community-acquired pneumonia: incidence, timing, risk factors, and association with short-term mortality (2012) Circulation, 125, pp. 773-781; Davidson, J.A., Warren-Gash, C., Cardiovascular complications of acute respiratory infections: current research and future directions (2019) Expert Rev Anti Infect Ther, 17, pp. 939-942; Gallagher, P.E., Ferrario, C.M., Tallant, E.A., Regulation of ACE2 in cardiac myocytes and fibroblasts (2008) Am J Physiol Heart Circ Physiol, 295, pp. H2373-H2479; Mendoza-Torres, E., Oyarzún, A., Mondaca-Ruff, D., ACE2 and vasoactive peptides: novel players in cardiovascular/renal remodeling and hypertension (2015) Ther Adv Cardiovasc Dis, 9, pp. 217-237; Xu, Z., Shi, L., Wang, Y., Pathological findings of COVID-19 associated with acute respiratory distress syndrome (2020) Lancet Respir Med, , published online Feb 18; Xu, D., Zhang, Z., Jin, L., Persistent shedding of viable SARS-CoV in urine and stool of SARS patients during the convalescent phase (2005) Eur J Clin Microbiol Infect Dis, 24, pp. 165-171; Corman, V.M., Albarrak, A.M., Omrani, A.S., Viral shedding and antibody response in 37 patients with Middle East Respiratory Syndrome coronavirus infection (2016) Clin Infect Dis, 62, pp. 477-483; Oh, M.D., Park, W.B., Choe, P.G., Viral load kinetics of MERS coronavirus infection (2016) N Engl J Med, 375, pp. 1303-1405; Wang, Y., Guo, Q., Yan, Z., Factors associated with prolonged viral shedding in patients with avian influenza A(H7N9) virus infection (2018) J Infect Dis, 217, pp. 1708-1717; Zou, L., Ruan, F., Huang, M., SARS-CoV-2 viral load in upper respiratory specimens of infected patients (2020) N Engl J Med, , published online Feb 19","Cao, B.; Department of Pulmonary and Critical Care Medicine, China-Japan Friendship HospitalChina; email: caobin_ben@163.com",,Lancet Publishing Group,1406736,,LANCA,32171076,English,Lancet,Article,Article in Press,Open Access,Scopus,2-s2.0-85081901579,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Chen Y.W., Yiu C.-P.B., Wong K.-Y.",57215844275;57215847501;57215840397;,"Prediction of the SARS-CoV-2 (2019-nCoV) 3C-like protease (3CL pro) structure: virtual screening reveals velpatasvir, ledipasvir, and other drug repurposing candidates",2020,F1000Research,9,,,129,,,,10.12688/f1000research.22457.1,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082083362&doi=10.12688%2ff1000research.22457.1&partnerID=40&md5=d98ac7684168e29836b2fb3812dc5524,"Department of Applied Biology & Chemical Technology, Hong Kong Polytechnic University, Hunghom, Hong Kong; State Key Laboratory of Chemical Biology and Drug Discovery, Hunghom, Hong Kong; Independent Researcher, La Costa, Ma On Shan, Hong Kong","Chen, Y.W., Department of Applied Biology & Chemical Technology, Hong Kong Polytechnic University, Hunghom, Hong Kong, State Key Laboratory of Chemical Biology and Drug Discovery, Hunghom, Hong Kong; Yiu, C.-P.B., Independent Researcher, La Costa, Ma On Shan, Hong Kong; Wong, K.-Y., Department of Applied Biology & Chemical Technology, Hong Kong Polytechnic University, Hunghom, Hong Kong, State Key Laboratory of Chemical Biology and Drug Discovery, Hunghom, Hong Kong","We prepared the three-dimensional model of the SARS-CoV-2 (aka 2019-nCoV) 3C-like protease (3CL pro) using the crystal structure of the highly similar (96% identity) ortholog from the SARS-CoV. All residues involved in the catalysis, substrate binding and dimerisation are 100% conserved. Comparison of the polyprotein PP1AB sequences showed 86% identity. The 3C-like cleavage sites on the coronaviral polyproteins are highly conserved. Based on the near-identical substrate specificities and high sequence identities, we are of the opinion that some of the previous progress of specific inhibitors development for the SARS-CoV enzyme can be conferred on its SARS-CoV-2 counterpart.  With the 3CL pro molecular model, we performed virtual screening for purchasable drugs and proposed 16 candidates for consideration. Among these, the antivirals ledipasvir or velpatasvir are particularly attractive as therapeutics to combat the new coronavirus with minimal side effects, commonly fatigue and headache.  The drugs Epclusa (velpatasvir/sofosbuvir) and Harvoni (ledipasvir/sofosbuvir) could be very effective owing to their dual inhibitory actions on two viral enzymes. Copyright: © 2020 Chen YW et al.",2019-nCoV; 3C-like protease; antiviral; coronavirus; COVID-19; drug repurpose; HCV; Hepatitis C virus; ledipasvir; molecular modelling; SARS; velpatasvir; virtual screening,"benzimidazole derivative; carbamic acid derivative; cysteine proteinase; fluorene derivative; fused heterocyclic rings; ledipasvir; severe acute respiratory syndrome coronavirus 2; velpatasvir; viral protein; Betacoronavirus; drug repositioning; Benzimidazoles; Betacoronavirus; Carbamates; Cysteine Endopeptidases; Drug Repositioning; Fluorenes; Heterocyclic Compounds, 4 or More Rings; Viral Nonstructural Proteins; Viral Proteins",,,,NLM (Medline),20461402,,,32194944,English,F1000Res,Article,Final,Open Access,Scopus,2-s2.0-85082083362,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Vichier-Guerre S., Ku T.C., Pochet S., Seley-Radtke K.L.",6602456248;56797697400;7006275356;12808128300;,An Expedient Synthesis of Flexible Nucleosides through Enzymatic Glycosylation of Proximal and Distal Fleximer Bases,2020,ChemBioChem,,,,,,,,10.1002/cbic.201900714,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080150743&doi=10.1002%2fcbic.201900714&partnerID=40&md5=65062380b7987752ca9afc5cb20b65ea,"Unité de Chimie et Biocatalyse, Institut Pasteur, CNRS UMR3523, 28, rue du Dr Roux, Paris, 75015, France; Department of Chemistry & Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, United States","Vichier-Guerre, S., Unité de Chimie et Biocatalyse, Institut Pasteur, CNRS UMR3523, 28, rue du Dr Roux, Paris, 75015, France; Ku, T.C., Department of Chemistry & Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, United States; Pochet, S., Unité de Chimie et Biocatalyse, Institut Pasteur, CNRS UMR3523, 28, rue du Dr Roux, Paris, 75015, France; Seley-Radtke, K.L., Department of Chemistry & Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, United States","The structurally unique “fleximer” nucleosides were originally designed to investigate how flexibility in a nucleobase could potentially affect receptor–ligand recognition and function. Recently they have been shown to have low-to-sub-micromolar levels of activity against a number of viruses, including coronaviruses, filoviruses, and flaviviruses. However, the synthesis of distal fleximers in particular has thus far been quite tedious and low yielding. As a potential solution to this issue, a series of proximal fleximer bases (flex-bases) has been successfully coupled to both ribose and 2′-deoxyribose sugars by using the N-deoxyribosyltransferase II of Lactobacillus leichmannii (LlNDT) and Escherichia coli purine nucleoside phosphorylase (PNP). To explore the range of this facile approach, transglycosylation experiments on a thieno-expanded tricyclic heterocyclic base, as well as several distal and proximal flex-bases were performed to determine whether the corresponding fleximer nucleosides could be obtained in this fashion, thus potentially significantly shortening the route to these biologically significant compounds. 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Chem., 17, pp. 7891-7899","Pochet, S.; Unité de Chimie et Biocatalyse, Institut Pasteur, CNRS UMR3523, 28, rue du Dr Roux, France; email: sylvie.pochet@pasteur.fr",,Wiley-VCH Verlag,14394227,,CBCHF,31899839,English,ChemBioChem,Article,Article in Press,Open Access,Scopus,2-s2.0-85080150743,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Chen W., Lan Y., Yuan X., Deng X., Li Y., Cai X., Li L., He R., Tan Y., Deng X., Gao M., Tang G., Zhao L., Wang J., Fan Q., Wen C., Tong Y., Tang Y., Hu F., Li F., Tang X.",57215198542;57215188437;56404755400;36986041100;57215210514;57203024841;57215197291;57215209323;57215201831;57211897151;57212818741;57215204701;56341101300;57215210222;57215192452;57215209050;57199872867;57215637343;16645756000;57200049008;8442040100;,Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity,2020,Emerging Microbes and Infections,9,1,,469,473,,,10.1080/22221751.2020.1732837,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080092738&doi=10.1080%2f22221751.2020.1732837&partnerID=40&md5=141954f22314b2d7d77f049ed1e15651,"Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, China","Chen, W., Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, China; Lan, Y., Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, China; Yuan, X., Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, China; Deng, X., Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, China; Li, Y., Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, China; Cai, X., Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, China; Li, L., Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, China; He, R., Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, China; Tan, Y., Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, China; Deng, X., Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, China; Gao, M., Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, China; Tang, G., Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, China; Zhao, L., Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, China; Wang, J., Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, China; Fan, Q., Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, China; Wen, C., Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, China; Tong, Y., Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, China; Tang, Y., Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, China; Hu, F., Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, China; Li, F., Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, China; Tang, X., Guangzhou Eighth People’s Hospital, Guangzhou Medical University, Guangzhou, China","The novel coronavirus (2019-nCoV) infection caused pneumonia. we retrospectively analyzed the virus presence in the pharyngeal swab, blood, and the anal swab detected by real-time PCR in the clinical lab. Unexpectedly, the 2109-nCoV RNA was readily detected in the blood (6 of 57 patients) and the anal swabs (11 of 28 patients). Importantly, all of the 6 patients with detectable viral RNA in the blood cohort progressed to severe symptom stage, indicating a strong correlation of serum viral RNA with the disease severity (p-value = 0.0001). Meanwhile, 8 of the 11 patients with annal swab virus-positive was in severe clinical stage. However, the concentration of viral RNA in the anal swab (Ct value = 24 + 39) was higher than in the blood (Ct value = 34 + 39) from patient 2, suggesting that the virus might replicate in the digestive tract. Altogether, our results confirmed the presence of virus RNA in extra-pulmonary sites. © 2020, © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd.",2019-ncov; anal swab; blood viral RNA; laboratory test; pharyngeal swab,"angiotensin converting enzyme 2; virus RNA; virus spike protein; COVID-19; severe acute respiratory syndrome coronavirus 2; virus RNA; 2019 novel coronavirus infection; blood sampling; clinical article; clinical laboratory; cohort analysis; consultation; Coronavirus infection; coughing; disease exacerbation; disease severity; endothelium cell; fever; hospital admission; human; intensive care unit; Letter; lung alveolus; lung lavage; lung lobe; medical care; medical history; patient information; pneumonia; practice guideline; priority journal; real time polymerase chain reaction; respiratory system; retrospective study; throat culture; virus detection; virus isolation; virus load; virus replication; virus transmission; Betacoronavirus; blood; Coronavirus infection; genetics; isolation and purification; severity of illness index; virology; virus pneumonia; Betacoronavirus; Coronavirus Infections; Humans; Pneumonia, Viral; Real-Time Polymerase Chain Reaction; Retrospective Studies; RNA, Viral; Severity of Illness Index","Wu, F., Zhao, S., Yu, B., A new coronavirus associated with human respiratory disease in China (2020) Nature, , https://doi.org/10.1038/s41586-020-2008-3, [Epub ahead of print]; Zhou, P., Yang, X.L., Wang, X.G., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature, , https://doi.org/10.1038/s41586-020-2012-7, [Epub ahead of print]; Chen, L., Liu, W., Zhang, Q., RNA based mNGS approach identifies a novel human coronavirus from two individual pneumonia cases in 2019 Wuhan outbreak (2020) Emerg Microbes Infect, 9 (1), pp. 313-319; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395 (10223), pp. 507-513; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395 (10223), pp. 497-506; Chen, L., Liu, H.G., Liu, W., Analysis of clinical features of 29 patients with 2019 novel coronavirus pneumonia (2020) Zhonghua Jie He He Hu Xi Za Zhi, 43, p. E005; Wan, Y., Shang, J., Graham, R., Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS (2020) J Virol, , https://doi.org/10.1128/JVI.00127-20, [Epub ahead of print]; Hamming, I., Timens, W., Bulthuis, M.L.C., Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis (2004) J Pathol, 203 (2), pp. 631-637; Zhou, P., Fan, H., Lan, T., Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin (2018) Nature, 556 (7700), pp. 255-258; Holshue, M.L., DeBolt, C., Lindquist, S., First case of 2019 novel coronavirus in the United States (2020) N Engl J Med, , https://doi.org/10.1056/NEJMoa2001191, [Epub ahead of print]","Hu, F.; Guangzhou Eighth People’s Hospital, Guangzhou Medical UniversityChina; email: gz8h_lifeng@126.com",,Taylor and Francis Ltd.,22221751,,,32102625,English,Emerg. Microbes Infect.,Letter,Final,Open Access,Scopus,2-s2.0-85080092738,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Qing E., Hantak M.P., Galpalli G.G., Gallagher T.",57207584493;56652220600;57212681798;7202310503;,Evaluating MERS-CoV entry pathways,2020,Methods in Molecular Biology,2099,,,9,20,,,10.1007/978-1-0716-0211-9_2,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077309100&doi=10.1007%2f978-1-0716-0211-9_2&partnerID=40&md5=9e14843257676283336ed56c03969958,"Department of Microbiology and Immunology, Loyola University Chicago, Maywood, IL, United States","Qing, E., Department of Microbiology and Immunology, Loyola University Chicago, Maywood, IL, United States; Hantak, M.P., Department of Microbiology and Immunology, Loyola University Chicago, Maywood, IL, United States; Galpalli, G.G., Department of Microbiology and Immunology, Loyola University Chicago, Maywood, IL, United States; Gallagher, T., Department of Microbiology and Immunology, Loyola University Chicago, Maywood, IL, United States","Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging zoonotic pathogen with a broad host range. The extent of MERS-CoV in nature can be traced to its adaptable cell entry steps. The virus can bind host-cell carbohydrates as well as proteinaceous receptors. Following receptor interaction, the virus can utilize diverse host proteases for cleavage activation of virus-host cell membrane fusion and subsequent genome delivery. The fusion and genome delivery steps can be completed at variable times and places, either at or near cell surfaces or deep within endosomes. Investigators focusing on the CoVs have developed several methodologies that effectively distinguish these different cell entry pathways. Here we describe these methods, highlighting virus-cell entry factors, entry inhibitors, and viral determinants that specify the cell entry routes. While the specific methods described herein were utilized to reveal MERS-CoV entry pathways, they are equally suited for other CoVs, as well as other protease-dependent viral species. © Springer Science+Business Media, LLC, part of Springer Nature 2020.",Coronavirus (CoV); Endosome; HR2 peptide; IFITM3; Middle East respiratory syndrome (MERS); Protease; Protease inhibitor; Pseudovirus; Spike (S); TMPRSS2; Transfection; Viral entry; Virus concentration; Virus purification,,"https://www.who.int/en/news-room/fact-sheets/detail/middle-east-respiratory-syndrome-coronavirus-(mers-cov), Accessed 4 Mar 2019; Sabir, J.S.M., Lam, T.T.Y., Ahmed, M.M.M., Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia (2016) Science, 351, pp. 81-84. , https://doi.org/10.1126/science.aac8608; Reusken, C.B.E.M., Haagmans, B.L., Müller, M.A., Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: A comparative serological study (2013) Lancet Infect Dis, 13, pp. 859-866. , https://doi.org/10.1016/S1473-3099(13)70164-6; 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Li, F., Structure, function, and evolution of coronavirus spike proteins (2016) Annu Rev Virol, 3, pp. 237-261. , https://doi.org/10.1146/annurev-virology-110615-042301; Hulswit, R.J.G., de Haan, C.A.M., Bosch, B.-J., Coronavirus spike protein and tropism changes (2016) Adv Virus Res, 96, pp. 29-57. , https://doi.org/10.1016/bs.aivir.2016.08.004; Millet, J.K., Whittaker, G.R., Host cell proteases: Critical determinants of coronavirus tropism and pathogenesis (2015) Virus Res, 202, pp. 120-134. , https://doi.org/10.1016/j.virusres.2014.11.021; Bugge, T.H., Antalis, T.M., Wu, Q., Type II Transmembraneserine proteases (2009) J Biol Chem, 284, pp. 23177-23181. , https://doi.org/10.1074/jbc.R109.021006; Park, J., Li, K., Barlan, A., Proteolytic processing of Middle East respiratory syndrome coronavirus spikes expands virus tropism (2016) Proc Natl Acad Sci U S A, 113, pp. 12262-12267. , https://doi.org/10.1073/pnas.1608147113; Earnest, J.T., Hantak, M.P., Li, K., Thetetraspanin CD9 facilitates MERS-coronavirus entry by scaffolding host cell receptors and proteases (2017) Plos Pathog, 13. , https://doi.org/10.1371/journal.ppat.1006546; Li, K., Wohlford-Lenane, C.L., Channappanavar, R., Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice (2017) Proc Natl Acad Sci, 114, pp. E3119-E3128. , https://doi.org/10.1073/pnas.1619109114; Shirato, K., Kanou, K., Kawase, M., Matsuyama, S., Clinical isolates of human coronavirus 229E bypass the endosome for cell entry (2017) J Virol, 91. , https://doi.org/10.1128/JVI.01387-16; Qiu, Z., Hingley, S.T., Simmons, G., Endosomal proteolysis by cathepsins is necessary for murine coronavirus mouse hepatitis virus type 2 spike-mediated entry (2006) J Virol, 80, pp. 5768-5776. , https://doi.org/10.1128/JVI.00442-06; Matsuyama, S., Taguchi, F., Two-step conformational changes in a coronavirus envelope glycoprotein mediated by receptor binding and proteolysis (2009) J Virol, 83, pp. 11133-11141. , https://doi.org/10.1128/JVI.00959-09; Bosch, B.J., Martina, B.E.E., van Der Zee, R., Severe acute respiratory syndrome coronavirus (SARS-CoV) infection inhibition using spike protein heptad repeat-derived peptides (2004) Proc Natl Acad Sci U S A, 101, pp. 8455-8460. , https://doi.org/10.1073/pnas.0400576101; Bosch, B.J., Rossen, J.W.A., Bartelink, W., Coronavirus escape from heptad repeat 2 (HR2)-derived peptide entry inhibition as a result of mutations in the HR1 domain of the spike fusion protein (2008) J Virol, 82, pp. 2580-2585. , https://doi.org/10.1128/JVI.02287-07; Park, J.E., Gallagher, T., Lipidation increases antiviral activities of coronavirus fusion-inhibiting peptides (2017) Virology, 511, pp. 9-18. , https://doi.org/10.1016/j.virol.2017.07.033; Wrensch, F., Winkler, M., Pöhlmann, S., IFITM proteins inhibit entry driven by the MERS-coronavirus spike protein: Evidence for cholesterol-independent mechanisms (2014) Viruses, 6, pp. 3683-3698. , https://doi.org/10.3390/v6093683; Zhao, X., Sehgal, M., Hou, Z., Identification of residues controlling restriction versus enhancing activities of IFITM proteins on entry of human coronaviruses (2017) J Virol, 92. , https://doi.org/10.1128/JVI.01535-17; Bradish, C.J., Brooksby, J.B., Dillon, J.F., Biophysical studies of the virus system of vesicular stomatitis (1956) J Gen Microbiol, 14, pp. 290-314. , https://doi.org/10.1099/00221287-14-2-290; Vogt, V., (1997) Retroviral Virions and Genomes, , Cold Spring Harbor Laboratory Press","Gallagher, T.; Department of Microbiology and Immunology, Loyola University ChicagoUnited States; email: tgallag@luc.edu",,Humana Press Inc.,10643745,,,31883084,English,Methods Mol. Biol.,Book Chapter,Final,Open Access,Scopus,2-s2.0-85077309100,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Moriyama M., Hugentobler W.J., Iwasaki A.",57206696188;57216080963;7201709462;,Annual review of virology seasonality of respiratory viral infections,2020,Annual Review of Virology,7,,,,,,,10.1146/annurev-virology-012420-022445,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082552134&doi=10.1146%2fannurev-virology-012420-022445&partnerID=40&md5=add0b7c229663dacf1fb3db09b78d5d8,"Department of Immunobiology, Yale University, School of Medicine, New Haven, CT 06520, United States; Institute of Primary Care, University of Zurich, University Hospital, Zurich, CH-8091, Switzerland; Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06512, United States; Howard Hughes Medical Institute, Chevy Chase, MD 20815, United States","Moriyama, M., Department of Immunobiology, Yale University, School of Medicine, New Haven, CT 06520, United States; Hugentobler, W.J., Institute of Primary Care, University of Zurich, University Hospital, Zurich, CH-8091, Switzerland; Iwasaki, A., Department of Immunobiology, Yale University, School of Medicine, New Haven, CT 06520, United States, Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06512, United States, Howard Hughes Medical Institute, Chevy Chase, MD 20815, United States","The seasonal cycle of respiratory viral diseases has been widely recognized for thousands of years, as annual epidemics of the common cold and influenza disease hit the human population like clockwork in the winter season in temperate regions. Moreover, epidemics caused by viruses such as severe acute respiratory syndrome coronavirus (SARS-CoV) and the newly emerging SARS-CoV-2 occur during the winter months. The mechanisms underlying the seasonal nature of respiratory viral infections have been examined and debated for many years. The two major contributing factors are the changes in environmental parameters and human behavior. Studies have revealed the effect of temperature and humidity on respiratory virus stability and transmission rates. More recent research highlights the importance of the environmental factors, especially temperature and humidity, in modulating host intrinsic, innate, and adaptive immune responses to viral infections in the respiratory tract. Here we review evidence of how outdoor and indoor climates are linked to the seasonality of viral respiratory infections. We further discuss determinants of host response in the seasonality of respiratory viruses by highlighting recent studies in the field. 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Commun., 6, p. 6426; Leigh, N.D., Kokolus, K.M., O'Neill, R.E., Du, W., Eng, J.W., Housing temperature-induced stress is suppressing murine graft-versus-host disease through β2-adrenergic receptor signaling (2015) J. Immunol., 195, pp. 5045-5054; Fox, S.J., Miller, J.C., Meyers, L.A., Seasonality in risk of pandemic influenza emergence (2017) PLOS Comput. Biol., 13; Medzhitov, R., Schneider, D.S., Soares, M.P., Disease tolerance as a defense strategy (2012) Science, 335, pp. 936-941; Molony, R.D., Nguyen, J.T., Kong, Y., Montgomery, R.R., Shaw, A.C., Iwasaki, A., Aging impairs both primary and secondary RIG-I signaling for interferon induction in human monocytes (2017) Sci. Signal., 10; Arundel, A.V., Sterling, E.M., Biggin, J.H., Sterling, T.D., Indirect health effects of relative humidity in indoor environments (1986) Environ. Health Perspect., 65, pp. 351-361; Zhou, P., Yang, X.-L., Wang, X.-G., Hu, B., Zhang, L., (2020) Discovery of a Novel Coronavirus Associated with the Recent Pneumonia Outbreak in Humans and its Potential Bat Origin, , https://doi.org/10.1101/2020.01.22.914952, bioRxiv 2020.01.22.914952; Letko, M., Munster, V., (2020) Functional Assessment of Cell Entry and Receptor Usage for Lineage B Βcoronaviruses, , https://doi.org/10.1101/2020.01.22.915660, including 2019-nCoV. bioRxiv 2020.01.22.915660; Zhao, Y., Zhao, Z., Wang, Y., Zhou, Y., Ma, Y., Zuo, W., (2020) Single-Cell RNA Expression Profiling of ACE2, the Putative Receptor of Wuhan 2019-nCov, , https://doi.org/10.1101/2020.01.26.919985, bioRxiv 2020.01.26.919985; Luo, W., Majumder, M.S., Liu, D., Poirier, C., Mandl, K.D., (2020) The Role of Absolute Humidity on Transmission Rates of the COVID-19 Outbreak, , https://doi.org/10.1101/2020.02.12.20022467, medRxiv 2020.02.12.20022467; Rondanelli, M., Miccono, A., Lamburghini, S., Avanzato, I., Riva, A., Self-care for common colds: The pivotal role of vitamin D, vitamin C, zinc, and echinacea in three main immune interactive clusters (physical barriers, innate and adaptive immunity) involved during an episode of common colds-practical advice on dosages and on the time to take these nutrients/botanicals in order to prevent or treat common colds (2018) Evid. Based Complement Alternat. Med., 2018, p. 5813095; Besedovsky, L., Lange, T., Haack, M., The sleep-immune crosstalk in health and disease (2019) Physiol. Rev., 99, pp. 1325-1380; Lee, B.Y., Shah, M., Prevention of influenza in healthy children (2012) Expert Rev. Anti. Infect. Ther., 10, pp. 1139-1152; Warren-Gash, C., Fragaszy, E., Hayward, A.C., Hand hygiene to reduce community transmission of influenza and acute respiratory tract infection: A systematic review. (2013) Influenza Other Respir. Viruses, 7, pp. 738-749; Ritzel, G., Sozialmedizinische Erhebungen zur Pathogenese und Prophylaxe von Erkältungskrankheiten (1966) Int. J. Public Health, 11, pp. 9-16; Sale, C.S., Humidification to reduce respiratory illnesses in nursery school children (1972) South Med. J., 65, pp. 882-885; Green, G.H., The effect of indoor relative humidity on absenteeism and colds in schools (1974) ASHRAE Trans, 80, pp. 131-141; Green, G.H., Indoor relative humidities in winter and the related absenteeism (1985) ASHRAE Trans, 91, pp. 643-656; Green, G.H., The positive and negative effects of building humidification (1982) ASHRAE Trans, 88, pp. 1049-1061; Gelperin, A., Humidification and upper respiratory infection incidence (1973) Heating, Piping, Air Conditioning, 45, pp. 77-78; Reiman, J.M., Das, B., Sindberg, G.M., Urban, M.D., Hammerlund, M.E.M., Humidity as a nonpharmaceutical intervention for influenza A (2018) PLOS ONE, 13","Iwasaki, A.; Department of Immunobiology, Yale University, School of MedicineUnited States; email: akiko.iwasaki@yale.edu",,Annual Reviews Inc.,2327056X,,,32196426,English,Annu. Rev. Virol.,Article,Final,Open Access,Scopus,2-s2.0-85082552134,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Fregene T.E., Nadarajah P., Buckley J.F., Bigham S., Nangalia V.",54402909700;57215972185;57212796997;8507763800;8557246000;,Use of in situ simulation to evaluate the operational readiness of a high-consequence infectious disease intensive care unit,2020,Anaesthesia,,,,,,,,10.1111/anae.15048,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082475492&doi=10.1111%2fanae.15048&partnerID=40&md5=da3a79d4aa8fa8e9a20af9c718995030,"Department of Anaesthesia, Royal Free Hospital, London, United Kingdom; Department of Intensive Care, Royal Free Hospital, London, United Kingdom","Fregene, T.E., Department of Anaesthesia, Royal Free Hospital, London, United Kingdom; Nadarajah, P., Department of Anaesthesia, Royal Free Hospital, London, United Kingdom; Buckley, J.F., Department of Intensive Care, Royal Free Hospital, London, United Kingdom; Bigham, S., Department of Anaesthesia, Royal Free Hospital, London, United Kingdom, Department of Intensive Care, Royal Free Hospital, London, United Kingdom; Nangalia, V., Department of Anaesthesia, Royal Free Hospital, London, United Kingdom","On 30 January 2020, the World Health Organization (WHO) declared that the outbreak of a coronavirus disease-2019 (COVID-19) was a public health emergency of international concern. The WHO guidance states that patients with (COVID-19) should be managed by staff wearing appropriate personal protective equipment; however, working whilst wearing personal protective equipment is unfamiliar to many healthcare professionals. We ran high-fidelity, in-situ simulation of high-risk procedures on patients with COVID-19 in a negative-pressure side room on our intensive care unit (ICU). Our aim was to identify potential problems, test the robustness of our systems and inform modification of our standard operating procedures for any patients with COVID-19 admitted to our ICU. The simulations revealed several important latent risks and allowed us to put corrective measures in place before the admission of patients with COVID-19. We recommend that staff working in clinical areas expected to receive patients with COVID-19 conduct in-situ simulation in order to detect their own unique risks and aid in the creation of local guidelines of management of patients with COVID-19. © 2020 Association of Anaesthetists",coronavirus; COVID-19; intensive care medicine; simulation,,"Wu, Z., McGoogan, J.M., Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in china: summary of a report of 72 314 cases from the chinese center for disease control and prevention (2020) Journal of the American Medical Association, 2019, pp. 3-6; Coronavirus disease 2019 (2020) World Health Organization, 2019, p. 2633; Ghani, A.C., Donnelly, C.A., Cox, D.R., Methods for estimating the case fatality ratio for a novel, emerging infectious disease (2005) American Journal of Epidemiology, 162, pp. 479-486; Xuanyue, M., Yanli, N., Hao, C., Pengli, J., Mingming, Z., Literature review regarding patient safety culture (2013) Journal of Evidence-Based Medicine, 6, pp. 43-49; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395, pp. 507-513; (2004) Summary of probable SARS cases with onset of illness from 1 November 2002 to 31 July 2003, , https://www.who.int/csr/sars/country/table2004_04_21/en, (accessed 12/03/2020); Hui, D.S., Epidemic and Emerging Coronaviruses (Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome) (2017) Clinics in Chest Medicine, 38, pp. 71-86; Tran, K., Cimon, K., Severn, M., Pessoa-Silva, C.L., Conly, J., Aerosol generating procedures and risk of transmission of acute respiratory infections to healthcare workers: a systematic review (2012) PLoS ONE, 7, pp. 10-11; Zuo, M.-Z., Huang, Y.-G., Ma, W.-H., Expert recommendations for tracheal intubation in critically ill patients with noval coronavirus disease 2019 (2020) Chinese Medical Sciences Journal, , https://doi.org/10.24920/003724, [Epub ahead of print]; Peng, P.W.H., Ho, P.-L., Hota, S.S., Outbreak of a new coronavirus: what anaesthetists should know (2020) British Journal of Anaesthesia, , https://doi.org/10.1016/j.bja.2020.02.008, [Epub ahead of print]; (2020) Clinical management of severe acute respiratory infection when novel coronavirus (2019-nCoV) infection is suspected: interim guidance, , https://apps.who.int/iris/handle/10665/330893, (accessed 12/03/2020); (2020) High consequence infectious diseases (HCID), , https://www.gov.uk/guidance/high-consequence-infectious-diseases-hcid#3classification-of-hcids, January, (accessed 10/03/2020); Reason, J., The Identification of Latent Organizational Failures in Complex Systems (1993) Verification and validation of complex systems: human factors issues, pp. 223-238. , Wise JA, Hopkin VD, Stager P, eds., Daytona, FL, Embry-Riddle Aeronautical University Press; Brazil, V., Translational simulation: not ‘where?’ but ‘why?’ A functional view of in situ simulation (2017) Advances in Simulation, 2, pp. 1-5","Nangalia, V.; Department of Anaesthesia, Royal Free HospitalUnited Kingdom; email: premala.nadarajah@nhs.net",,Blackwell Publishing Ltd,32409,,ANASA,,English,Anaesthesia,Article,Article in Press,,Scopus,2-s2.0-85082475492,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Goh K.J., Choong M.C., Cheong E.H., Kalimuddin S., Duu Wen S., Phua G.C., Chan K.S., Haja Mohideen S.",57215907329;57215908067;57215907423;35484514100;57215908772;57215908061;57215908557;57190381451;,Rapid Progression to Acute Respiratory Distress Syndrome: Review of Current Understanding of Critical Illness from COVID-19 Infection,2020,"Annals of the Academy of Medicine, Singapore",49,1,,1,9,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082342379&partnerID=40&md5=f105b76d7f78c4975cb7ba182e53def5,"Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore","Goh, K.J., Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore; Choong, M.C.; Cheong, E.H.; Kalimuddin, S.; Duu Wen, S.; Phua, G.C.; Chan, K.S.; Haja Mohideen, S.","The coronavirus disease 2019 (COVID-19) outbreak that started in Wuhan, Hubei province, China in December 2019 has now extended across the globe with >100,000 cases and 3,000 deaths reported in 93 countries as of 7 March 2020. We report a case of COVID-19 infection in a 64-year-old man who developed rapidly worsening respiratory failure and acute respiratory distress syndrome (ARDS) that required intubation. As the clinical spectrum of COVID-19 ranges widely from mild illness to ARDS with a high risk of mortality, there is a need for more research to identify early markers of disease severity. Current evidence suggests that patients with advanced age, pre-existing comorbidities or dyspnoea should be closely monitored, especially at 1-2 weeks after symptom onset. It remains to be seen if laboratory findings such as lymphopenia or elevated lactate dehydrogenase may serve as early surrogates for critical illness or markers of disease recovery. Management of ARDS in COVID-19 remains supportive while we await results of drug trials. More studies are needed to understand the incidence and outcomes of ARDS and critical illness from COVID-19, which will be important for critical care management and resource planning.",,"COVID-19; severe acute respiratory syndrome coronavirus 2; adult respiratory distress syndrome; Betacoronavirus; case report; complication; Coronavirus infection; critical illness; disease exacerbation; human; intensive care; isolation and purification; male; middle aged; patient care planning; risk factor; severity of illness index; virology; virus pneumonia; Betacoronavirus; Coronavirus Infections; Critical Care; Critical Illness; Disease Progression; Humans; Male; Middle Aged; Patient Care Planning; Pneumonia, Viral; Respiratory Distress Syndrome, Adult; Risk Factors; Severity of Illness Index",,,,NLM (Medline),3044602,,,32200400,English,Ann. Acad. Med. Singap.,Article,Final,,Scopus,2-s2.0-85082342379,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Lee Y., Kang B.-H., Kang M., Chung D.R., Yi G.-S., Lee L.P., Jeong K.-H.",56092312000;57200193513;55453175300;57215692396;7101660754;8244322300;7201556494;,Nanoplasmonic On-Chip PCR for Rapid Precision Molecular Diagnostics,2020,ACS Applied Materials and Interfaces,,,,,,,,10.1021/acsami.9b23591,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081648335&doi=10.1021%2facsami.9b23591&partnerID=40&md5=0a4e39f4d7a05984012cfb7feafcc66d,"Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, South Korea; Kaist Institute for Health Science and Technology (KIHST), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, South Korea; Biomedical Engineering Research Center, Smart Healthcare Research Institute, Samsung Medical Center, Seoul, 06351, South Korea; Dept. of Med. Device Mgmt. and Res., Saihst (Samsung Adv. Inst. for Health Sciences and Technology), Sungkyunkwan University, Seoul, 06351, South Korea; Division of Infectious Disease, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, 06351, South Korea; Center for Infection Prevention and Control, Samsung Medical Center, Seoul, 06351, South Korea; Asia Pacific Foundation for Infectious Diseases (APFID), Seoul, 06351, South Korea; Department of Bioengineering, University of California, Berkeley, CA 94720, United States; Berkeley Sensor and Actuator Center, University of California, Berkeley, CA 94720, United States; Department of Electrical Engineering and Computer Science, University of California, Berkeley, CA 94720, United States; Biophysics Graduate Program, University of California, Berkeley, CA 94720, United States","Lee, Y., Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, South Korea, Kaist Institute for Health Science and Technology (KIHST), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, South Korea; Kang, B.-H., Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, South Korea, Kaist Institute for Health Science and Technology (KIHST), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, South Korea; Kang, M., Biomedical Engineering Research Center, Smart Healthcare Research Institute, Samsung Medical Center, Seoul, 06351, South Korea, Dept. of Med. Device Mgmt. and Res., Saihst (Samsung Adv. Inst. for Health Sciences and Technology), Sungkyunkwan University, Seoul, 06351, South Korea; Chung, D.R., Division of Infectious Disease, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, 06351, South Korea, Center for Infection Prevention and Control, Samsung Medical Center, Seoul, 06351, South Korea, Asia Pacific Foundation for Infectious Diseases (APFID), Seoul, 06351, South Korea; Yi, G.-S., Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, South Korea; Lee, L.P., Department of Bioengineering, University of California, Berkeley, CA 94720, United States, Berkeley Sensor and Actuator Center, University of California, Berkeley, CA 94720, United States, Department of Electrical Engineering and Computer Science, University of California, Berkeley, CA 94720, United States, Biophysics Graduate Program, University of California, Berkeley, CA 94720, United States; Jeong, K.-H., Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, South Korea, Kaist Institute for Health Science and Technology (KIHST), Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, South Korea","Emerging molecular diagnosis requires ultrafast polymerase chain reaction (PCR) on chip for rapid precise detection of infectious diseases in the point-of-care test. Here, we report nanoplasmonic on-chip PCR for rapid precision molecular diagnostics. The nanoplasmonic pillar arrays (NPA) comprise gold nanoislands on the top and sidewall of large-scale glass nanopillar arrays. The nanoplasmonic pillars enhance light absorption of a white light-emitting diode (LED) over the whole visible range due to strong electromagnetic hotspots between the nanoislands. As a result, they effectively induce photothermal heating for ultrafast PCR thermal cycling. The temperature profile of NPA exhibits 30 cycles between 98 and 60 °C for a total of 3 min and 30 s during the cyclic excitation of white LED light. The experimental results also demonstrate the rapid DNA amplification of both 0.1 ng μL-1 of λ-DNA in 20 thermal cycles and 0.1 ng μL-1 of complementary DNA of Middle East respiratory syndrome coronavirus in 30 thermal cycles using a conventional PCR volume of 15 μL. This nanoplasmonic PCR technique provides a new opportunity for rapid precision molecular diagnostics. © Copyright © 2020 American Chemical Society.",molecular diagnostics; nanopillar; photothermal effect; point-of-care diagnosis; polymerase chain reaction,Diagnosis; DNA; Light absorption; Light emitting diodes; Molecular biology; Nanopillars; Thermal cycling; Molecular diagnosis; Molecular diagnostics; NanoPillar; Photothermal effects; Photothermal heating; Point of care; Temperature profiles; White light emitting diodes; Polymerase chain reaction,"Cao, L., Cui, X., Hu, J., Li, Z., Choi, J.R., Yang, Q., Lin, M., Xu, F., Advances in Digital Polymerase Chain Reaction (dPCR) and Its Emerging Biomedical Applications (2017) Biosens. Bioelectron., 90, pp. 459-474; Brennan, D.J., O'Connor, D.P., Rexhepaj, E., Ponten, F., Gallagher, W.M., Antibody-Based Proteomics: Fast-Tracking Molecular Diagnostics in Oncology (2010) Nat. Rev. Cancer, 10, pp. 605-617; Xiao, M.S., Lai, W., Man, T.T., Chang, B.B., Li, L., Chandrasekaran, A.R., Pei, H., Rationally Engineered Nucleic Acid Architectures for Biosensing Applications (2019) Chem. Rev., 119, pp. 11631-11717; Katsanis, S.H., Katsanis, N., Molecular Genetic Testing and the Future of Clinical Genomics (2013) Nat. Rev. Genet., 14, pp. 415-426; Lu, X., Whitaker, B., Sakthivel, S.K.K., Kamili, S., Rose, L.E., Lowe, L., Mohareb, E., Erdman, D.D., Real-Time Reverse Transcription-PCR Assay Panel for Middle East Respiratory Syndrome Coronavirus (2014) J. Clin. Microbiol., 52, pp. 67-75; Niemz, A., Ferguson, T.M., Boyle, D.S., Point-of-Care Nucleic Acid Testing for Infectious Diseases (2011) Trends Biotechnol., 29, pp. 240-250; Song, Y., Huang, Y.-Y., Liu, X., Zhang, X., Ferrari, M., Qin, L., Point-of-Care Technologies for Molecular Diagnostics Using a Drop of Blood (2014) Trends Biotechnol., 32, pp. 132-139; Peeling, R.W., Mabey, D., Point-of-Care Tests for Diagnosing Infections in the Developing World (2010) Clin. Microbiol. Infect., 16, pp. 1062-1069; Wu, G., Zaman, M.H., Low-Cost Tools for Diagnosing and Monitoring HIV Infection in Low-Resource Settings (2012) Bull W. H. O., 90, pp. 914-920; Saiki, R.K., Scharf, S., Faloona, F., Mullis, K.B., Horn, G.T., Erlich, H.A., Arnheim, N., Enzymatic Amplification of Beta-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia (1985) Science, 230, pp. 1350-1354; Baker, M., Clever PCR: More Genotyping, Smaller Volumes (2010) Nat. Methods, 7, pp. 351-356; Postollec, F., Falentin, H., Pavan, S., Combrisson, J., Sohier, D., Recent Advances in Quantitative PCR (Qpcr) Applications in Food Microbiology (2011) Food Microbiol., 28, pp. 848-861; Erlich, H.A., Gelfand, D., Sninsky, J.J., Recent Advances in the Polymerase Chain Reaction (1991) Science, 252, pp. 1643-1651; Qiu, X., Yuan, J., Temperature Control for PCR Thermocyclers Based on Peltier-Effect Thermoelectric (2006) Conf. Proc. Ieee Eng. Med. Biol. Soc., 7, pp. 7509-7512; Lyon, E., Wittwer, C.T., Lightcycler Technology in Molecular Diagnostics (2009) J. Mol. Diagn., 11, pp. 93-101; Ahrberg, C.D., Manz, A., Chung, B.G., Polymerase Chain Reaction in Microfluidic Devices (2016) Lab Chip, 16, pp. 3866-3884; Foudeh, A.M., Didar, T.F., Veres, T., Tabrizian, M., Microfluidic Designs and Techniques Using Lab-on-a-Chip Devices for Pathogen Detection for Point-of-Care Diagnostics (2012) Lab Chip, 12, pp. 3249-3266; Chen, D., Mauk, M., Qiu, X., Liu, C., Kim, J., Ramprasad, S., Ongagna, S., Bau, H.H., An Integrated, Self-Contained Microfluidic Cassette for Isolation, Amplification, and Detection of Nucleic Acids (2010) Biomed. Microdevices, 12, pp. 705-719; Liu, P., Li, X., Greenspoon, S.A., Scherer, J.R., Mathies, R.A., Integrated DNA Purification, PCR, Sample Cleanup, and Capillary Electrophoresis Microchip for Forensic Human Identification (2011) Lab Chip, 11, pp. 1041-1048; Jiang, L., Mancuso, M., Lu, Z., Akar, G., Cesarman, E., Erickson, D., Solar Thermal Polymerase Chain Reaction for Smartphone-Assisted Molecular Diagnostics (2015) Sci. Rep., 4, pp. 1-5; Kopp, M.U., De Mello, A.J., Manz, A., Chemical Amplification: Continuous-Flow PCR on a Chip (1998) Science, 280, pp. 1046-1048; Kim, H., Vishniakou, S., Faris, G.W., Petri Dish PCR: Laser-Heated Reactions in Nanoliter Droplet Arrays (2009) Lab Chip, 9, pp. 1230-1235; Terazono, H., Hattori, A., Takei, H., Takeda, K., Yasuda, K., Development of 1480 Nm Photothermal High-Speed Real-Time Polymerase Chain Reaction System for Rapid Nucleotide Recognition (2008) Jpn. J. Appl. Phys., 47, pp. 5212-5216; Baffou, G., Quidant, R., Thermo-Plasmonics: Using Metallic Nanostructures as Nano-Sources of Heat (2013) Laser Photonics Rev., 7, pp. 171-187; Clavero, C., Plasmon-Induced Hot-Electron Generation at Nanoparticle/Metal-Oxide Interfaces for Photovoltaic and Photocatalytic Devices (2014) Nat. Photonics, 8, pp. 95-103; Furube, A., Du, L., Hara, K., Katoh, R., Tachiya, M., Ultrafast Plasmon-Induced Electron Transfer from Gold Nanodots into Tio2 Nanoparticles (2007) J. Am. Chem. Soc., 129, pp. 14852-14853; Roche, P.J.R., Najih, M., Lee, S.S., Beitel, L.K., Carnevale, M.L., Paliouras, M., Kirk, A.G., Trifiro, M.A., Real Time Plasmonic Qpcr: How Fast Is Ultra-Fast? 30 Cycles in 54 Seconds (2017) Analyst, 142, pp. 1746-1755; Son, J.H., Cho, B., Hong, S., Lee, S.H., Hoxha, O., Haack, A.J., Lee, L.P., Ultrafast Photonic PCR (2015) Light: Sci. Appl., 4; Son, J.H., Hong, S., Haack, A.J., Gustafson, L., Song, M., Hoxha, O., Lee, L.P., Rapid Optical Cavity PCR (2016) Adv. Healthcare Mater., 5, pp. 167-174; Kielbassa, C., Roza, L., Epe, B., Wavelength Dependence of Oxidative DNA Damage Induced by Uv and Visible Light (1997) Carcinogenesis, 18, pp. 811-816; Oh, Y.-J., Jeong, K.-H., Glass Nanopillar Arrays with Nanogap-Rich Silver Nanoislands for Highly Intense Surface Enhanced Raman Scattering (2012) Adv. Mater., 24, pp. 2234-2237; Roche, P.J.R., Beitel, L.K., Khan, R., Lumbroso, R., Najih, M., Cheung, M.C.-K., Thiemann, J., Kirk, A.G., Demonstration of a Plasmonic Thermocycler for the Amplification of Human Androgen Receptor DNA (2012) Analyst, 137, pp. 4475-4481; Zhou, L., Tan, Y., Ji, D., Zhu, B., Zhang, P., Xu, J., Gan, Q., Zhu, J., Self-Assembly of Highly Efficient, Broadband Plasmonic Absorbers for Solar Steam Generation (2016) Sci. Adv., 2; Wu, D.Y., Ugozzoli, L., Pal, B.K., Qian, J., Wallace, R.B., The Effect of Temperature and Oligonucleotide Primer Length on the Specificity and Efficiency of Amplification by the Polymerase Chain Reaction (1991) DNA Cell Biol., 10, pp. 233-238","Jeong, K.-H.; Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST)South Korea; email: lplee@Berkeley.edu",,American Chemical Society,19448244,,,32101396,English,ACS Appl. Mater. Interfaces,Article,Article in Press,,Scopus,2-s2.0-85081648335,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Mohammadpour R., Champour M., Tuteja F., Mostafavi E.",57215609398;56094717800;8391301300;22135676300;,Zoonotic implications of camel diseases in Iran,2020,Veterinary Medicine and Science,,,,,,,,10.1002/vms3.239,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081397723&doi=10.1002%2fvms3.239&partnerID=40&md5=fee478e935e1e529162621b5ae83ec29,"Department of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging infectious diseases, Pasteur Institute of Iran, Tehran, Iran; Department of Clinical Sciences, School of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran; National Research Centre on Camel, Bikaner, Rajasthan, India","Mohammadpour, R., Department of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging infectious diseases, Pasteur Institute of Iran, Tehran, Iran; Champour, M., Department of Clinical Sciences, School of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran; Tuteja, F., National Research Centre on Camel, Bikaner, Rajasthan, India; Mostafavi, E., Department of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging infectious diseases, Pasteur Institute of Iran, Tehran, Iran","Approximately 60% of all human pathogens and 75% of emerging infectious diseases are zoonotic (of animal origin). Camel zoonotic diseases can be encountered in all camel-rearing countries. In this article, all studies carried out on camel zoonotic diseases in Iran are reviewed to show the importance of camels for public health in this country. More than 900 published documents were systematically searched to find relevant studies from 1,890 until late 2018. The collected articles were classified according to the aetiological agents. In this study, 19 important zoonotic diseases were reported among Iranian camels including listeriosis, leptospirosis, plague, Q fever, brucellosis, campylobacteriosis, tuberculosis, pasteurellosis, clostridiosis, salmonellosis, Escherichia coli infections, rabies, camelpox, Middle East respiratory syndrome coronavirus, Crimean-Congo haemorrhagic fever, echinococcosis, cryptosporidiosis, toxoplasmosis and dermatophytosis, most of which belong to bacterial, viral, parasitic and fungal pathogens, respectively. Results show that camels are one of the most important sources of infections and diseases in human; therefore, continuous monitoring and inspection programs are necessary to prevent the outbreak of zoonotic diseases caused by this animal in humans. © 2020 The Authors. Veterinary Medicine and Science Published by John Wiley & Sons Ltd",dromedary camel; epidemiology; Middle East; zoonoses,,"",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, (Camelus dromedarius) in Qeshm Island, Southern Iran (2010) Comparative Clinical Pathology, 19 (3), pp. 311-314. , https://doi.org/10.1007/s00580-009-0862-3; Nigg, A.J., Walker, P.L., Overview, prevention, and treatment of rabies (2009) Pharmacotherapy, 29 (10), pp. 1182-1195. , https://doi.org/10.1592/phco.29.10.1182; Ningal, S.P., Kothule, M.B., Jadhav, N.Y., Kadam, S.D., Katare, Y.S., Hapse, S.A., A review on leptospirosis (2015) Epidemiology, 3 (4), pp. 5-8; Norlander, L., Q fever epidemiology and pathogenesis (2000) Microbes and Infection, 2 (4), pp. 417-424. , https://doi.org/10.1016/S1286-4579(00)00325-7; Nour-Mohammadzadeh, F., Baradaran Seyed, Z., Hesaraki, S., Yadegari, Z., Alidadi, N., Sattari Tabrizi, S., Septicemic salmonellosis in a two-humped camel calf (Camelus bactrianus) (2010) Tropical Animal Health and Production, 42 (8), pp. 1601-1604. , https://doi.org/10.1007/s11250-010-9626-y; Oosterom, J., Epidemiological studies and proposed preventive measures in the fight against human salmonellosis (1991) International Journal of Food Microbiology, 12 (1), pp. 41-51. , https://doi.org/10.1016/0168-1605(91)90046-R; Otero-Abad, B., Torgerson, P.R., A systematic review of the epidemiology of echinococcosis in domestic and wild animals (2013) PLoS Neglected Tropical Diseases, 7 (6). , https://doi.org/10.1371/journal.pntd.0002249; Pappas, G., Papadimitriou, P., Akritidis, N., Christou, L., Tsianos, E.V., The new global map of human brucellosis (2006) The Lancet Infectious Diseases, 6 (2), pp. 91-99. , https://doi.org/10.1016/S1473-3099(06)70382-6; Pieniazek, N.J., Knight, R., Grimes, B.H., Veal, D.A., Da silva, A.J., Graczyk, T.K., Detection of cryptosporidium parvum and Giardia lamblia carried by synanthropic flies by combined fluorescent in situ hybridization and a monoclonal antibody (2003) The American Journal of Tropical Medicine and Hygiene, 68 (2), pp. 228-232. , https://doi.org/10.4269/ajtmh.2003.68.228; Pirouz, M.H.J., Mohammadi, G.R., Mehrzad, J., Aziz zadeh, M., (2016) Investigation of Coxiella burnetii infection in camel population of northeast of Iran with qPCR, , The Second National Congress of Camel in Iran, Hormozgan. 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Zowghi, E., Ebadi, A.," """"Brucellosis in camels in Iran (1991) Razi State Vaccine and Serum Institute", 40 (2)," pp. 111-115""","Mostafavi, E.; Department of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging infectious diseases, Pasteur Institute of IranIran; email: mostafaviehsan@gmail.com",,Wiley-Blackwell,20531095,,,,English,Vet. Med. Sci.,Review,Article in Press,Open Access,Scopus,2-s2.0-85081397723,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Shi Z., Wang W., Xu Z., Zhao M., Lan Y.",56049798500;57204003829;57210890117;57194234267;56723420900;,Detection and molecular characterization of BCoVs circulating in central China based on the full-length spike gene [Orta çin’de sığır koronavirusun tam uzunlukta spike genine dayalı tespiti ve moleküler karakterizasyonu],2020,Kafkas Universitesi Veteriner Fakultesi Dergisi,26,2, KVFD-2019-22678,181,186,,,10.9775/kvfd.2019.22678,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078355379&doi=10.9775%2fkvfd.2019.22678&partnerID=40&md5=42697097928336839e6e33e5c35c572b,"Institute of Animal Husbandry and Veterinary, Henan Academy of Agricultural Sciences, Zhengzhou, Henan 450002, China; College of Pharmaceutical Engineering, Henan University of Animal Husbandry and Economy, Zhengzhou, Henan 450046, China; Henan Key Laboratory of Farm Animal Breeding and Nutritional Regulation, Zhengzhou, Henan 450002, China; School of Life Science and Engineering, Foshan University, Foshan, Guangdong 528225, China","Shi, Z., Institute of Animal Husbandry and Veterinary, Henan Academy of Agricultural Sciences, Zhengzhou, Henan 450002, China, Henan Key Laboratory of Farm Animal Breeding and Nutritional Regulation, Zhengzhou, Henan 450002, China; Wang, W., College of Pharmaceutical Engineering, Henan University of Animal Husbandry and Economy, Zhengzhou, Henan 450046, China; Xu, Z., Institute of Animal Husbandry and Veterinary, Henan Academy of Agricultural Sciences, Zhengzhou, Henan 450002, China, Henan Key Laboratory of Farm Animal Breeding and Nutritional Regulation, Zhengzhou, Henan 450002, China; Zhao, M., School of Life Science and Engineering, Foshan University, Foshan, Guangdong 528225, China; Lan, Y., Institute of Animal Husbandry and Veterinary, Henan Academy of Agricultural Sciences, Zhengzhou, Henan 450002, China, Henan Key Laboratory of Farm Animal Breeding and Nutritional Regulation, Zhengzhou, Henan 450002, China","Bovine coronavirus (BCoV) is prevalent throughout the world and is an important aetiological agent of diarrhoea in new-born calves. However, little is known about the genetic diversity and molecular epidemiology of BCoV in China. In this study, a total of 127 faecal samples from diarrhoeic dairy calves from nine cities in Henan Province, Central China, were collected between 2017 and 2018 and evaluated by RT-PCR for the N gene. BCoV was detected in 15% (19/127) of calves. In addition, the full-length sequence of the S gene from 13 representative BCoV strains was obtained and analysed. Sequencing results for the full-length S gene showed 97.3-97.5% nucleotide (nt) identity and 96.3-96.8% amino acid (aa) identity with the classical Mebus strain. Phylogenetic analysis based on the full-length S gene showed that the BCoV strains in this study clustered with Vietnamese and Cuban BCoV strains on a large branch of the tree. These results enrich the molecular characterization of the Chinese BCoV strains and provide the first large-scale epidemiological examination of the prevalence of BCoV in diarrhoeic calves in Henan Province, Central China. © 2020, Veteriner Fakultesi Dergisi. All rights reserved.",BCoV; China; Phylogenetic analysis; Spike gene,nucleotide; amino acid sequence; animal experiment; Article; Bovine coronavirus; Coronavirus infection; diarrhea; feces analysis; gene; gene amplification; gene deletion; gene sequence; genetic analysis; genetic distance; genetic variability; geographic distribution; molecular epidemiology; nonhuman; phylogeny; polymerase chain reaction; prevalence; real time polymerase chain reaction,"Castells, M., Giannitti, F., Caffarena, R.D., Casaux, M.L., Schild, C., Castells, D., Riet-Correa, F., Colina, R., Bovine coronavirus in Uruguay: Genetic diversity, risk factors and transboundary introductions from neighboring countries (2019) Arch Virol, 164 (11), pp. 2715-2724; Aleanizy, F.S., Mohmed, N., Alqahtani, F.Y., Mohamed RAEH: Outbreak of Middle East respiratory syndrome coronavirus in Saudi Arabia: A retrospective study (2017) BMC Infect Dis, 17, p. 23; Giannitti, F., Diab, S., Mete, A., Stanton, J.B., Fielding, L., Crossley, B., Sverlow, K., Pusterla, N., Necrotizing enteritis and hyperammonemic encephalopathy associated with equine coronavirus infection in equids (2015) Vet Pathol, 52 (6), pp. 1148-1156; Singasa, K., Songserm, T., Lertwatcharasarakul, P., Arunvipas, P., Molecular and phylogenetic characterization of bovine coronavirus virus isolated from dairy cattle in Central Region, Thailand (2017) Trop Anim Health Prod, 49 (7), pp. 1523-1529; Gunn, L., Collins, P.J., O’Connell, M.J., O’Shea, H., Phylogenetic investigation of enteric bovine coronavirus in Ireland reveals partitioning between European and global strains (2015) Irish Vet J, 68; Gomez, D.E., Arroyo, L.G., Poljak, Z., Viel, L., Weese, J.S., Detection of bovine coronavirus in healthy and diarrheic dairy calves (2017) J Vet Intern Med, 31 (6), pp. 1884-1891; Ribeiro, J., Lorenzetti, E., Alfieri, A.F., Alfieri, A.A., Molecular detection of bovine coronavirus in a diarrhea outbreak in pasture-feeding Nellore steers in southern Brazil (2016) Trop Anim Health Prod, 48 (3), pp. 649-653; Masters, P.S., The Molecular biology of coronaviruses (2006) Adv Virus Res, 66 (1), pp. 193-292; Yoo, D., Deregt, D., A single amino acid change within antigenic domain II of the spike protein of bovine coronavirus confers resistance to virus neutralization (2001) Clin Diagn Lab Immunol, 8 (2), pp. 297-302; Gallagher, T.M., Buchmeier, M.J., Coronavirus spike proteins in viral entry and pathogenesis (2001) Virology, 279 (2), pp. 371-374; Lu, C.P., Yao, H.C., Eichhorn, W., Coronavirus as an agent of neonatal calf diarrhea in a Chinese dairy cattle farm (1991) Zentralbl Veterinarmed B, 38 (1-10), pp. 473-476; Rambaut, A., (2009) Figtree V1.4.3, , http://tree.bio.ed.ac.uk/software/figtree/, Accessed: 25.03.2014; Gao, F., Chen, C., Arab, D.A., Du, Z., He, Y., Ho, S.Y.W., EasyCodeML: A visual tool for analysis of selection using CodeML (2019) Ecol Evol, 9 (7), pp. 3891-3898; Lojkić, I., Krešić, N., Šimić, I., Bedeković, T., Detection and molecular characterisation of bovine corona and toroviruses from Croatian cattle (2015) BMC Vet Res, 11; Park, S.J., Jeong, C., Yoon, S.S., Choy, H.E., Saif, L.J., Park, S.H., Kim, Y.J., Cho, K.O., Detection and characterization of bovine coronaviruses in fecal specimens of adult cattle with diarrhea during the warmer seasons (2006) J Clin Microbiol, 44 (9), pp. 3178-3188; Keha, A., Xue, L., Yan, S., Yue, H., Tang, C., Prevalence of a novel bovine coronavirus strain with a recombinant hemagglutinin/esterase gene in dairy calves in China (2019) Transbound Emerg Dis, 66 (5), pp. 1971-1981; Dennis, A.F., McDonald, S.M., Payne, D.C., Slavica, M.R., Esona, M.D., Edwards, K.M., Chappell, J.D., Patton, J.T., Molecular epidemiology of contemporary G2P[4] human rotaviruses cocirculating in a single U.S. community: Footprints of a globally transitioning genotype (2014) J Virol, 88 (7), pp. 3789-3801; de Mira Fernandes, A., Brandão, P.E., Dos Santos Lima, M., de Souza Nunes Martins, M., da Silva, T.G., da Silva Cardoso Pinto, V., de Paula, L.T., Pituco, E.M., Genetic diversity of BCoV in Brazilian cattle herds. Vet (2018) Med Sci, 4, pp. 183-189; Li, F., Structure, Function, and evolution of coronavirus spike proteins (2016) Annu Rev Virol, 3 (1), pp. 237-261; Forni, D., Filippi, G., Cagliani, R., Gioia, L.D., Pozzoli, U., Aldaghri, N., Clerici, M., Sironi, M., The heptad repeat region is a major selection target in MERS-CoV and related coronaviruses (2015) Sci Rep, 5; Graham, R.L., Baric, R.S., Recombination, reservoirs, and the modular spike: Mechanisms of coronavirus cross-species transmission (2010) J Virol, 84 (7), pp. 3134-3146; Yoo, D.W., Parker, M.D., Song, J., Cox, G.J., Deregt, D., Babiuk, L.A., Structural analysis of the conformational domains involved in neutralization of bovine coronavirus using deletion mutants of the spike glycoprotein S1 subunit expressed by recombinant baculoviruses (1991) Virology, 183 (1), pp. 91-98","Zhao, M.; School of Life Science and Engineering, Foshan UniversityChina; email: mzhao8@tulane.edu",,Veteriner Fakultesi Dergisi,13006045,,,,English,Kafkas Universitesi Veteriner Fakultesi Dergisi,Article,Final,Open Access,Scopus,2-s2.0-85078355379,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Dong W., Xie W., Liu Y., Sui B., Zhang H., Liu L., Tan Y., Tong X., Fu Z.F., Yin P., Fang L., Peng G.",56921147900;57205688684;57211868926;56989016100;56988380200;57211868727;57211874029;57211873763;7403347700;55261079500;7402470374;56651662900;,Receptor tyrosine kinase inhibitors block proliferation of TGEV mainly through p38 mitogen-activated protein kinase pathways,2020,Antiviral Research,173,,104651,,,,,10.1016/j.antiviral.2019.104651,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85075194071&doi=10.1016%2fj.antiviral.2019.104651&partnerID=40&md5=7bc2e159a15f4ec3062113c6fc075897,"The State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan, 430070, China; National Key Laboratory of Crop Genetic Improvement, National Centre of Plant Gene Research, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China; Department of Veterinary Medicine, College of Animal Science and Technology, Zhejiang A&F University, Hangzhou, 311300, China; Departments of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, United States","Dong, W., The State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China, The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan, 430070, China, National Key Laboratory of Crop Genetic Improvement, National Centre of Plant Gene Research, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China, Department of Veterinary Medicine, College of Animal Science and Technology, Zhejiang A&F University, Hangzhou, 311300, China; Xie, W., The State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China, The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan, 430070, China; Liu, Y., The State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China, The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan, 430070, China; Sui, B., The State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China, The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan, 430070, China; Zhang, H., The State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China, The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan, 430070, China; Liu, L., The State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China, The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan, 430070, China; Tan, Y., The State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China, The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan, 430070, China; Tong, X., The State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China, The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan, 430070, China; Fu, Z.F., The State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China, The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan, 430070, China, Departments of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, United States; Yin, P., National Key Laboratory of Crop Genetic Improvement, National Centre of Plant Gene Research, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China; Fang, L., The State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China, The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan, 430070, China; Peng, G., The State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China, The Cooperative Innovation Center for Sustainable Pig Production, Huazhong Agricultural University, Wuhan, 430070, China","Emerging coronaviruses (CoVs) primarily cause severe gastroenteric or respiratory diseases in humans and animals, and no approved therapeutics are currently available. Here, A9, a receptor tyrosine kinase inhibitor (RTKI) of the tyrphostin class, is identified as a robust inhibitor of transmissible gastroenteritis virus (TGEV) infection in cell-based assays. Moreover, A9 exhibited potent antiviral activity against the replication of various CoVs, including murine hepatitis virus (MHV), porcine epidemic diarrhea virus (PEDV) and feline infectious peritonitis virus (FIPV). We further performed a comparative phosphoproteomic analysis to investigate the mechanism of action of A9 against TGEV infection in vitro. We specifically identified p38 and JNK1, which are the downstream molecules of receptor tyrosine kinases (RTKs) required for efficient TGEV replication, as A9 targets through plaque assays, qRT-PCR and Western blotting assays. p38 and JNK1 inhibitors and RNA interference further showed that the inhibitory activity of A9 against TGEV infection was mainly mediated by the p38 mitogen-activated protein kinase (MAPK) signaling pathway. All these findings indicated that the RTKI A9 directly inhibits TGEV replication and that its inhibitory activity against TGEV replication mainly occurs by targeting p38, which provides vital clues to the design of novel drugs against CoVs. © 2019",Anti-coronaviral therapy; Comparative phosphoproteomic; Receptor tyrosine kinase inhibitor; Virus-host interaction,a9; antivirus agent; elongation factor Tu; mitogen activated protein kinase p38; protein tyrosine kinase inhibitor; unclassified drug; Alphacoronavirus; antiviral activity; Article; cell proliferation; controlled study; Feline infectious peritonitis virus; high throughput screening; MAPK signaling; Murine hepatitis virus; nonhuman; nucleotide sequence; phosphoproteomics; PK-15 cell line; plaque assay; Porcine epidemic diarrhea virus; priority journal; protein isolation; protein phosphorylation; RNA interference; Transmissible gastroenteritis virus; virus infection; virus replication; virus titration; Western blotting,"Anand, A.R., Prasad, A., Bradley, R.R., Deol, Y.S., Nagaraja, T., Ren, X., Terwilliger, E.F., Ganju, R.K., HIV-1 gp120-induced migration of dendritic cells is regulated by a novel kinase cascade involving Pyk2, p38 MAP kinase, and LSP1 (2009) Blood, 114, pp. 3588-3600; Banerjee, S., Narayanan, K., Mizutani, T., Makino, S., Murine coronavirus replication-induced p38 mitogen-activated protein kinase activation promotes interleukin-6 production and virus replication in cultured cells (2002) J. 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Biol., 19, pp. 2435-2444; Schlessinger, J., Cell signaling by receptor tyrosine kinases (2000) Cell, 103, pp. 211-225; Shin, G.C., Chung, Y.S., Kim, I.S., Cho, H.W., Kang, C., Antigenic characterization of severe acute respiratory syndrome-coronavirus nucleocapsid protein expressed in insect cells: the effect of phosphorylation on immunoreactivity and specificity (2007) Virus Res., 127, pp. 71-80; Spencer, K.A., Dee, M., Britton, P., Hiscox, J.A., Role of phosphorylation clusters in the biology of the coronavirus infectious bronchitis virus nucleocapsid protein (2008) Virology, 370, pp. 373-381; Stantchev, T.S., Markovic, I., Telford, W.G., Clouse, K.A., Broder, C.C., The tyrosine kinase inhibitor genistein blocks HIV-1 infection in primary human macrophages (2007) Virus Res., 123, pp. 178-189; Tong, T.R., Drug targets in severe acute respiratory syndrome (SARS) virus and other coronavirus infections (2009) Infect. Disord. - Drug Targets, 9, pp. 223-245; Vela, E.M., Bowick, G.C., Herzog, N.K., Aronson, J.F., Genistein treatment of cells inhibits arenavirus infection (2008) Antivir. Res., 77, pp. 153-156; White, T.C., Yi, Z., Hogue, B.G., Identification of mouse hepatitis coronavirus A59 nucleocapsid protein phosphorylation sites (2007) Virus Res., 126, pp. 139-148; Wu, C.H., Chen, P.J., Yeh, S.H., Nucleocapsid phosphorylation and RNA helicase DDX1 recruitment enables coronavirus transition from discontinuous to continuous transcription (2014) Cell Host Microbe, 16, pp. 462-472; Yang, L., Xu, J., Guo, L., Guo, T., Zhang, L., Feng, L., Chen, H., Wang, Y., Porcine epidemic diarrhea virus-induced epidermal growth factor receptor activation impairs the antiviral activity of type I interferon (2018) J. Virol., 92; Yura, Y., Yoshida, H., Sato, M., Inhibition of herpes simplex virus replication by genistein, an inhibitor of protein-tyrosine kinase (1993) Arch. Virol., 132, pp. 451-461; Zachos, G., Koffa, M., Preston, C.M., Clements, J.B., Conner, J., Herpes simplex virus type 1 blocks the apoptotic host cell defense mechanisms that target Bcl-2 and manipulates activation of p38 mitogen-activated protein kinase to improve viral replication (2001) J. Virol., 75, pp. 2710-2728; Zhang, Y., Wei, Y., Li, J., Li, J., Development and optimization of a direct plaque assay for human and avian metapneumoviruses (2012) J. Virol Methods, 185, pp. 61-68; Zhou, Y., Agudelo, J., Lu, K., Goetz, D.H., Hansell, E., Chen, Y.T., Roush, W.R., Simmons, G., Inhibitors of SARS-CoV entry--identification using an internally-controlled dual envelope pseudovirion assay (2011) Antivir. Res., 92, pp. 187-194","Peng, G.; State-key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural UniversityChina; email: penggq@mail.hzau.edu.cn",,Elsevier B.V.,1663542,,ARSRD,31751591,English,Antiviral Res.,Article,Final,Open Access,Scopus,2-s2.0-85075194071,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wilder-Smith A., Chiew C.J., Lee V.J.",35509574300;57216086172;57216110803;,Can we contain the COVID-19 outbreak with the same measures as for SARS?,2020,The Lancet Infectious Diseases,,,,,,,1,10.1016/S1473-3099(20)30129-8,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082469873&doi=10.1016%2fS1473-3099%2820%2930129-8&partnerID=40&md5=4405c1a3411fabf1aea50ef3f9ef6c86,"London School of Hygiene and Tropical Medicine, London, United Kingdom; Heidelberg Institute of Global Health, University of Heidelberg, Heidelberg, Germany; Lee Kong Chian School of Medicine, Singapore, Singapore; National University Health System, Singapore, Singapore; Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore","Wilder-Smith, A., London School of Hygiene and Tropical Medicine, London, United Kingdom, Heidelberg Institute of Global Health, University of Heidelberg, Heidelberg, Germany, Lee Kong Chian School of Medicine, Singapore, Singapore; Chiew, C.J., National University Health System, Singapore, Singapore; Lee, V.J., Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore","The severe acute respiratory syndrome (SARS) outbreak in 2003 resulted in more than 8000 cases and 800 deaths. SARS was eventually contained by means of syndromic surveillance, prompt isolation of patients, strict enforcement of quarantine of all contacts, and in some areas top-down enforcement of community quarantine. By interrupting all human-to-human transmission, SARS was effectively eradicated. By contrast, by Feb 28, 2020, within a matter of 2 months since the beginning of the outbreak of coronavirus disease 2019 (COVID-19), more than 82 000 confirmed cases of COVID-19 have been reported with more than 2800 deaths. Although there are striking similarities between SARS and COVID-19, the differences in the virus characteristics will ultimately determine whether the same measures for SARS will also be successful for COVID-19. COVID-19 differs from SARS in terms of infectious period, transmissibility, clinical severity, and extent of community spread. Even if traditional public health measures are not able to fully contain the outbreak of COVID-19, they will still be effective in reducing peak incidence and global deaths. Exportations to other countries need not result in rapid large-scale outbreaks, if countries have the political will to rapidly implement countermeasures. © 2020 Elsevier Ltd",,,"Chan, J.F., Kok, K.H., Zhu, Z., Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan (2020) Emerg Microbes Infect, 9, pp. 221-236; Jia, H.P., Look, D.C., Shi, L., ACE2 receptor expression and severe acute respiratory syndrome coronavirus infection depend on differentiation of human airway epithelia (2005) J Virol, 79, pp. 14614-14621; Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382, pp. 727-733; Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med, , published online Jan 29; Lipsitch, M., Cohen, T., Cooper, B., Transmission dynamics and control of severe acute respiratory syndrome (2003) Science, 300, pp. 1966-1970; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395, pp. 507-513; Holshue, M.L., DeBolt, C., Lindquist, S., First case of 2019 novel coronavirus in the United States (2020) N Engl J Med, , published online Jan 31; Pan, F., Ye, T., Sun, P., Time course of lung changes on chest CT during recovery from 2019 novel coronavirus (COVID-19) pneumonia (2020) Radiology, , published online Feb 13; Wilder-Smith, A., Freedman, D.O., Isolation, quarantine, social distancing and community containment: pivotal role for old-style public health measures in the novel coronavirus (2019-nCoV) outbreak (2020) J Travel Med, , published online Feb 13; Cetron, M., Simone, P., Battling 21st-century scourges with a 14th-century toolbox (2004) Emerg Infect Dis, 10, pp. 2053-2054; Cheng, P.K., Wong, D.A., Tong, L.K., Viral shedding patterns of coronavirus in patients with probable severe acute respiratory syndrome (2004) Lancet, 363, pp. 1699-1700; Li, Y., Yu, I.T., Xu, P., Predicting super spreading events during the 2003 severe acute respiratory syndrome epidemics in Hong Kong and Singapore (2004) Am J Epidemiol, 160, pp. 719-728; Gumel, A.B., Ruan, S., Day, T., Modelling strategies for controlling SARS outbreaks (2004) Proc Biol Sci, 271, pp. 2223-2232; Wilson-Clark, S.D., Deeks, S.L., Gournis, E., Household transmission of SARS, 2003 (2006) CMAJ, 175, pp. 1219-1223; Goh, K.T., Cutter, J., Heng, B.H., Epidemiology and control of SARS in Singapore (2006) Ann Acad Med Singapore, 35, pp. 301-316; Wilder-Smith, A., Green, J.A., Paton, N.I., Hospitalized patients with bacterial infections: a potential focus of SARS transmission during an outbreak (2004) Epidemiol Infect, 132, pp. 407-408; Cetron, M., Landwirth, J., Public health and ethical considerations in planning for quarantine (2005) Yale J Biol Med, 78, pp. 329-334; Svoboda, T., Henry, B., Shulman, L., Public health measures to control the spread of the severe acute respiratory syndrome during the outbreak in Toronto (2004) N Engl J Med, 350, pp. 2352-2361; Tsang, T., Lam, T.H., SARS: public health measures in Hong Kong (2003) Respirology, 8, pp. S46-S48; Ahmad, A., Krumkamp, R., Reintjes, R., Controlling SARS: a review on China's response compared with other SARS-affected countries (2009) Trop Med Int Health, 14, pp. 36-45; de Vlas, S.J., Feng, D., Cooper, B.S., Fang, L.Q., Cao, W.C., Richardus, J.H., The impact of public health control measures during the SARS epidemic in mainland China (2009) Trop Med Int Health, 14, pp. 101-104; Leung, G.M., Quah, S., Ho, L.M., A tale of two cities: community psychobehavioral surveillance and related impact on outbreak control in Hong Kong and Singapore during the severe acute respiratory syndrome epidemic (2004) Infect Control Hosp Epidemiol, 25, pp. 1033-1041; Leung, G.M., Hedley, A.J., Ho, L.M., The epidemiology of severe acute respiratory syndrome in the 2003 Hong Kong epidemic: an analysis of all 1755 patients (2004) Ann Intern Med, 141, pp. 662-673; McDonald, L.C., Simor, A.E., Su, I.J., SARS in healthcare facilities, Toronto and Taiwan (2004) Emerg Infect Dis, 10, pp. 777-781; Tan, C.C., SARS in Singapore—key lessons from an epidemic (2006) Ann Acad Med Singapore, 35, pp. 345-349; Wilder-Smith, A., Paton, N.I., Goh, K.T., Experience of severe acute respiratory syndrome in Singapore: importation of cases, and defense strategies at the airport (2003) J Travel Med, 10, pp. 259-262; Wilder-Smith, A., The severe acute respiratory syndrome: impact on travel and tourism (2006) Travel Med Infect Dis, 4, pp. 53-60; McCloskey, B., Heymann, D.L., SARS to novel coronavirus—old lessons and new lessons (2020) Epidemiol Infect, 148, p. e22; Wang, C., Horby, P.W., Hayden, F.G., Gao, G.F., A novel coronavirus outbreak of global health concern (2020) Lancet, 395, pp. 470-473; Nkengasong, J., China's response to a novel coronavirus stands in stark contrast to the 2002 SARS outbreak response (2020) Nat Med, , published online Jan 27; Wilson, M.E., Chen, L.H., Travelers give wings to novel coronavirus (2019-nCoV) (2020) J Travel Med, , published online Feb 3; Bogoch, I.I., Watts, A., Thomas-Bachli, A., Potential for global spread of a novel coronavirus from China (2020) J Travel Med, , published online Jan 27; Bogoch, I.I., Watts, A., Thomas-Bachli, A., Huber, C., Kraemer, M.U.G., Khan, K., Pneumonia of unknown etiology in Wuhan, China: potential for international spread via commercial air travel (2020) J Travel Med, , published online Jan 14; Wilder-Smith, A., Teleman, M.D., Heng, B.H., Earnest, A., Ling, A.E., Leo, Y.S., Asymptomatic SARS coronavirus infection among healthcare workers, Singapore (2005) Emerg Infect Dis, 11, pp. 1142-1145; Rothe, C., Schunk, M., Sothmann, P., Transmission of 2019-nCoV infection from an asymptomatic contact in Germany (2020) N Engl J Med, , published online Jan 30; Phan, L.T., Nguyen, T.V., Luong, Q.C., Importation and human-to-human transmission of a novel coronavirus in Vietnam (2020) N Engl J Med, , published online Jan 28; Quilty, B.J., Clifford, S., Flasche, S., Effectiveness of airport screening at detecting travellers infected with novel coronavirus (2019-nCoV) (2020) Euro Surveill, 25; Liu, Y., Gayle, A.A., Wilder-Smith, A., Rocklöv, J., The reproductive number of COVID-19 is higher compared to SARS coronavirus (2020) J Travel Med, , published online Feb 13; Rocklöv, J., Sjödin, H., Wilder-Smith, A., COVID-19 outbreak on the Diamond Princess cruise ship: estimating the epidemic potential and effectiveness of public health countermeasures (2020) J Travel Med, , published online Feb 28; The Epidemiological Characteristics of an Outbreak of 2019 Novel Coronavirus Diseases (COVID-19)—China, 2020. China CDC Weekly 2020 http://weekly.chinacdc.cn/en/article/id/e53946e2-c6c4-41e9-9a9b-fea8db1a8f51, (Accessed 28 February 2020)","Wilder-Smith, A.; London School of Hygiene and Tropical MedicineUnited Kingdom; email: annelies.wilder-smith@lshtm.ac.uk",,Lancet Publishing Group,14733099,,LIDAB,32145768,English,Lancet Infect. Dis.,Review,Article in Press,Open Access,Scopus,2-s2.0-85082469873,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wujtewicz M., Dylczyk-Sommer A., Aszkiełowicz A., Zdanowski S., Piwowarczyk S., Owczuk R.",57201982042;22950765700;57215864858;56543617400;57215865519;6602795391;,COVID-19 - what should anaethesiologists and intensivists know about it?,2020,Anaesthesiology intensive therapy,52,1,,34,41,,,10.5114/ait.2020.93756,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082146869&doi=10.5114%2fait.2020.93756&partnerID=40&md5=f4eb5f86e748608919ae25c47f6d11d3,"Department of Anaesthesiology and Intensive Therapy, Medical University of Gdańsk, Gdańsk, Poland; Students' Scientific Society at the Medical University of Gdańsk, Gdańsk, Poland","Wujtewicz, M., Department of Anaesthesiology and Intensive Therapy, Medical University of Gdańsk, Gdańsk, Poland; Dylczyk-Sommer, A., Department of Anaesthesiology and Intensive Therapy, Medical University of Gdańsk, Gdańsk, Poland; Aszkiełowicz, A., Department of Anaesthesiology and Intensive Therapy, Medical University of Gdańsk, Gdańsk, Poland; Zdanowski, S., Students' Scientific Society at the Medical University of Gdańsk, Gdańsk, Poland; Piwowarczyk, S., Students' Scientific Society at the Medical University of Gdańsk, Gdańsk, Poland; Owczuk, R., Department of Anaesthesiology and Intensive Therapy, Medical University of Gdańsk, Gdańsk, Poland","Over the past three months, the world has faced an unprecedented health hazard. The World Health Organization has announced a pandemic infection with an unknown species of coronavirus called SARS-CoV-2. Spreading mainly through the droplet route, the virus causes mild symptoms in the majority of cases, the most common being: fever (80%), dry cough (56%), fatigue (22%) and muscle pain (7%); less common symptoms include a sore throat, a runny nose, diarrhea, hemoptysis and chills. A life-threatening complication of SARS-CoV-2 infection is an acute respiratory distress syndrome (ARDS), which occurs more often in older adults, those with immune disorders and co-morbidities. Severe forms of the infection, being an indication for treatment in the intensive care unit, comprise acute lung inflammation, ARDS, sepsis and septic shock. The article presents basic information about etiology, pathogenesis and diagnostics (with particular emphasis on the importance of tomocomputer imaging), clinical picture, treatment and prevention of the infection. It goes on to emphasize the specific risks of providing anesthesiology and intensive care services. Due to the fact that effective causal treatment is not yet available and the number of infections and deaths increases day by day, infection prevention and strict adherence to recommendations of infection control organizations remain the basis for fighting the virus.",acute respiratory distress syndrome (ARDS); acute pneumonia; COVID-19; infection; SARS-CoV-2; viruses,"age; anesthesiologist; attitude to health; Betacoronavirus; Coronavirus infection; coughing; disease exacerbation; fever; human; psychology; risk factor; virus pneumonia; Age Factors; Anesthesiologists; Betacoronavirus; Coronavirus Infections; Cough; Disease Progression; Fever; Health Knowledge, Attitudes, Practice; Humans; Pneumonia, Viral; Risk Factors",,,,NLM (Medline),17312531,,,32191830,English,Anaesthesiol Intensive Ther,Review,Final,Open Access,Scopus,2-s2.0-85082146869,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Cortegiani A., Ingoglia G., Ippolito M., Giarratano A., Einav S.",56041745800;6508293637;57200697319;57201345041;56193119800;,A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19,2020,Journal of Critical Care,,,,,,,,10.1016/j.jcrc.2020.03.005,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081702276&doi=10.1016%2fj.jcrc.2020.03.005&partnerID=40&md5=afc5b617ea6e0e71aa48ec2cc302e276,"Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anaesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo, Italy; Intensive Care Unit of the Shaare Zedek Medical Medical Centre, Hebrew University Faculty of Medicine, Jerusalem, Israel","Cortegiani, A., Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anaesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo, Italy; Ingoglia, G., Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anaesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo, Italy; Ippolito, M., Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anaesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo, Italy; Giarratano, A., Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anaesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo, Italy; Einav, S., Intensive Care Unit of the Shaare Zedek Medical Medical Centre, Hebrew University Faculty of Medicine, Jerusalem, Israel","Purpose: COVID-19 (coronavirus disease 2019) is a public health emergency of international concern. As of this time, there is no known effective pharmaceutical treatment, although it is much needed for patient contracting the severe form of the disease. The aim of this systematic review was to summarize the evidence regarding chloroquine for the treatment of COVID-19. Methods: PubMed, EMBASE, and three trial Registries were searched for studies on the use of chloroquine in patients with COVID-19. Results: We included six articles (one narrative letter, one in-vitro study, one editorial, expert consensus paper, two national guideline documents) and 23 ongoing clinical trials in China. Chloroquine seems to be effective in limiting the replication of SARS-CoV-2 (virus causing COVID-19) in vitro. Conclusions: There is rationale, pre-clinical evidence of effectiveness and evidence of safety from long-time clinical use for other indications to justify clinical research on chloroquine in patients with COVID-19. However, clinical use should either adhere to the Monitored Emergency Use of Unregistered Interventions (MEURI) framework or be ethically approved as a trial as stated by the World Health Organization. Safety data and data from high-quality clinical trials are urgently needed. © 2020 Elsevier Inc.",Chloroquine; Coronavirus; COVID-19; Pneumonia; SARS-CoV-2,,"Wu, Z., McGoogan, J.M., Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention (2020) Jama; Savarino, A., Boelaert, J.R., Cassone, A., Majori, G., Cauda, R., Effects of chloroquine on viral infections: an old drug against today's diseases? (2003) Lancet Infect Dis, 3, pp. 722-727; Colson, P., Rolain, J.-M., Raoult, D., Chloroquine for the 2019 novel coronavirus SARS-CoV-2 (2020) Int J Antimicrob Agents, p. 105923; https://www.who.int/blueprint/priority-diseases/keyaction/Table_of_therapeutics_Appendix_17022020.pdf?ua=1, Accessed on 2nd March 2020; Gao, J., Tian, Z., Yang, X., Breakthrough: chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies (2020) Biosci Trends; Wang, M., Cao, R., Zhang, L., Yang, X., Liu, J., Xu, M., Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro (2020) Cell Res; Expert consensus on chloroquine phosphate for the treatment of novel coronavirus pneumonia (2020) Zhonghua Jie He He Hu Xi Za Zhi, 43. , E019–9; https://lci.rivm.nl/covid-19/bijlage/behandeladvies, (Accessed on 6th March 2020); http://www.simit.org/medias/1555-covid19-linee-guida-trattamento-01mar.pdf, (Accessed on 6th March 2020); https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports/, (Accessed on 5th March 2020); http://www.xinhuanet.com/english/2020-02/28/c_138828090.htm, (Accessed on 2th March 2020); Guan, W.-J., Ni, Z.-Y., Hu, Y., Liang, W.-H., Ou, C.-Q., He, J.-X., Clinical Characteristics of Coronavirus Disease 2019 in China (2020) N Engl J Med, , NEJMoa2002032; Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) Jama; Yang, X., Yu, Y., Xu, J., Shu, H., Xia, J., Liu, H., Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study (2020) Lancet Respir Med; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506; https://www.who.int/blueprint/priority-diseases/key-action/multicenter-adaptive-RCT-of-investigational-therapeutics-for-COVID-19.pdf?ua=1, (Accessed on 6th Mrch 2020); https://www.who.int/docs/default-source/coronaviruse/clinical-management-of-novel-cov.pdf, (Accessed on 6th March 2020); Lenk, C., Duttge, G., Ethical and legal framework and regulation for off-label use: European perspective (2014) Ther Clin Risk Manag, 10, pp. 537-546","Cortegiani, A.; Department of Surgical, Oncological and Oral Science (Di.Chir.On.S.), Section of Anesthesia, Analgesia, Intensive Care and Emergency, Policlinico Paolo Giaccone, University of Palermo, Via del vespro 129, Italy; email: andrea.cortegiani@unipa.it",,W.B. Saunders,8839441,,JCCAE,,English,J. Crit. Care,Article,Article in Press,Open Access,Scopus,2-s2.0-85081702276,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Lagier J.C., Colson P., Tissot Dupont H., Salomon J., Doudier B., Aubry C., Gouriet F., Baron S., Dudouet P., Flores R., Ailhaud L., Gautret P., Parola P., La Scola B., Raoult D., Brouqui P.",24366829400;7102090499;7004136755;57213365918;16042284300;57197128782;6506398797;57190620393;57215685485;57215695259;57215684296;36893462000;7006212186;7007051194;57208853524;7005522769;,Testing the repatriated for SARS-Cov2: Should laboratory-based quarantine replace traditional quarantine?,2020,Travel Medicine and Infectious Disease,,,101624,,,,,10.1016/j.tmaid.2020.101624,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081680616&doi=10.1016%2fj.tmaid.2020.101624&partnerID=40&md5=0768d708ebc4fd245a652a24518a7791,"Aix Marseille Univ, IRD, AP-HM, MEPHI, IHU Méditerranée Infection, Marseille, France; Ministry of Health, Paris, France; Aix-Marseille Univ, IRD, AP-HM, SSA, VITROME, IHU-Méditerranée Infection, Marseille, France","Lagier, J.C., Aix Marseille Univ, IRD, AP-HM, MEPHI, IHU Méditerranée Infection, Marseille, France; Colson, P., Aix Marseille Univ, IRD, AP-HM, MEPHI, IHU Méditerranée Infection, Marseille, France; Tissot Dupont, H., Aix Marseille Univ, IRD, AP-HM, MEPHI, IHU Méditerranée Infection, Marseille, France; Salomon, J., Ministry of Health, Paris, France; Doudier, B., Aix Marseille Univ, IRD, AP-HM, MEPHI, IHU Méditerranée Infection, Marseille, France; Aubry, C., Aix-Marseille Univ, IRD, AP-HM, SSA, VITROME, IHU-Méditerranée Infection, Marseille, France; Gouriet, F., Aix Marseille Univ, IRD, AP-HM, MEPHI, IHU Méditerranée Infection, Marseille, France; Baron, S., Aix Marseille Univ, IRD, AP-HM, MEPHI, IHU Méditerranée Infection, Marseille, France; Dudouet, P., Aix Marseille Univ, IRD, AP-HM, MEPHI, IHU Méditerranée Infection, Marseille, France; Flores, R., Aix Marseille Univ, IRD, AP-HM, MEPHI, IHU Méditerranée Infection, Marseille, France; Ailhaud, L., Aix Marseille Univ, IRD, AP-HM, MEPHI, IHU Méditerranée Infection, Marseille, France; Gautret, P., Aix-Marseille Univ, IRD, AP-HM, SSA, VITROME, IHU-Méditerranée Infection, Marseille, France; Parola, P., Aix-Marseille Univ, IRD, AP-HM, SSA, VITROME, IHU-Méditerranée Infection, Marseille, France; La Scola, B., Aix Marseille Univ, IRD, AP-HM, MEPHI, IHU Méditerranée Infection, Marseille, France; Raoult, D., Aix Marseille Univ, IRD, AP-HM, MEPHI, IHU Méditerranée Infection, Marseille, France; Brouqui, P., Aix Marseille Univ, IRD, AP-HM, MEPHI, IHU Méditerranée Infection, Marseille, France","Background: An ongoing epidemic of respiratory diseases caused by a novel coronavirus (COVID 2019, SARS-CoV2) started in Wuhan, Hubei, in China at the end of December 2019. The French government decided to repatriate the 337 French nationals living in Wuhan and place them in quarantine in their home country. We decided to test them all for SARS-Cov2 twice in order to reduce anxiety among the population and decision-makers. Methods: We investigated the presence of SARS-CoV-19 in asymptomatic carriers by testing all repatriated patients within the first 24 h of their arrival in France and at day 5. Viral RNA was extracted from pooled nasal and oropharyngeal swab fluids or sputum in the absence of nasal/oropharyngeal swabs. Detection of SARS-CoV-2 RNA was then carried out using several real-time reverse transcription (RT)-PCR assays. Results: We tested 337 passengers at day 0 and day 5. All the tests for SARS-CoV2 were negative. By optimising the sampling process, sending samples sequentially and reducing the time-scale for biological analysis, we were able to test the samples within 5 h (including sampling, shipment and biological tests). Conclusion: Optimising our procedures reduces anxiety and reassures the population and decision makers. © 2020",Anxiety; Coronavirus; COVID-19; Early; Quarantine; Rapid testing,,"Al-Tawfiq, J.A., Asymptomatic coronavirus infection: MERS-CoV and SARS-CoV-2(COVID-19) (2020) Trav Med Infect Dis, p. 101608; Huang, Y., Tu, M., Wang, S., Chen, S., Zhou, W., Chen, D., Clinical characteristics of laboratory confirmed positive cases of SARS-CoV-2 infection in Wuhan, China: a retrospective single center analysis (2020) Trav Med Infect Dis, p. 101606; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Cao, B., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506; (2020) Coronavirus disease 2019 situation report -28, , WHO; Gensini, G.F., Yacoub, M.H., Conti, A.A., The concept of quarantine in history: from plague to SARS (2004) J Infect, 49, pp. 257-261; Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med; Corman, V.M., Landt, O., Kaiser, M., Molenkamp, R., Meijer, A., Chu, D.K., Bleicker, T., Drosten, C., Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR (2020) EuroSurveill, 25. , 10-7917; Ninove, L., Nougairede, A., Gazin, C., Thirion, L., Delogu, I., Zandotti, C., Charrel, R.N., de L, X., RNA and DNA bacteriophages as molecular diagnosis controls in clinical virology: a comprehensive study of more than 45,000 routine PCR tests (2011) PloS One, 6; Drancourt, M., Michel-Lepage, A., Boyer, S., Raoult, D., The point-of-care laboratory in clinical microbiology (2016) Clin Microbiol Rev, 29, pp. 429-447; Kahneman, D., Tversky, A., Choices, values, and frames (1984) Am Psychol, 39, pp. 341-350; Zhang, S., Diao, M., Yu, W., Pei, L., Lin, Z., Chen, D., Estimation of the reproductive number of Novel Coronavirus (COVID-19) and the probable outbreak size on the Diamond Princess cruise ship: a data-driven analysis (2020) Int J Infect Dis, (20), pp. 30091-30096. , pii: S1201-9712; Al-Tawfiq, J.A., Gautret, P., Asymptomatic Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection: extent and implications for infection control: a systematic review (2019) Trav Med Infect Dis, 27, pp. 27-32","Lagier, J.C.; IHU - Méditerranée Infection, 19-21 Bd Jean Moulin Marseille, France; email: jean-christophe.lagier@univ-amu.fr",,Elsevier USA,14778939,,TMIDA,,English,Travel Med. Infect. Dis.,Article,Article in Press,Open Access,Scopus,2-s2.0-85081680616,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Si F., Hu X., Wang C., Chen B., Wang R., Dong S., Yu R., Li Z.",25951682800;57215049846;57215053166;57194518583;57215037095;16021551800;16023653700;35240240000;,Porcine epidemic diarrhea virus (PEDV) ORF3 enhances viral proliferation by inhibiting apoptosis of infected cells,2020,Viruses,12,2,214,,,,,10.3390/v12020214,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079793415&doi=10.3390%2fv12020214&partnerID=40&md5=a544288906d8243a0657521318e7f463,"Institute of Animal Science and Veterinary Medicine, Shanghai Key Laboratory of Agricultural Genetics and Breeding, Shanghai Academy of Agricultural Sciences, Shanghai, 201106, China; Shanghai Engineering Research Center of Breeding Pig, Shanghai, 201106, China; National Demonstration Center for Experimental Fisheries Science Education, Shanghai Ocean University, Shanghai, 201306, China","Si, F., Institute of Animal Science and Veterinary Medicine, Shanghai Key Laboratory of Agricultural Genetics and Breeding, Shanghai Academy of Agricultural Sciences, Shanghai, 201106, China, Shanghai Engineering Research Center of Breeding Pig, Shanghai, 201106, China; Hu, X., Institute of Animal Science and Veterinary Medicine, Shanghai Key Laboratory of Agricultural Genetics and Breeding, Shanghai Academy of Agricultural Sciences, Shanghai, 201106, China, Shanghai Engineering Research Center of Breeding Pig, Shanghai, 201106, China; Wang, C., Institute of Animal Science and Veterinary Medicine, Shanghai Key Laboratory of Agricultural Genetics and Breeding, Shanghai Academy of Agricultural Sciences, Shanghai, 201106, China, National Demonstration Center for Experimental Fisheries Science Education, Shanghai Ocean University, Shanghai, 201306, China; Chen, B., Institute of Animal Science and Veterinary Medicine, Shanghai Key Laboratory of Agricultural Genetics and Breeding, Shanghai Academy of Agricultural Sciences, Shanghai, 201106, China, Shanghai Engineering Research Center of Breeding Pig, Shanghai, 201106, China; Wang, R., Institute of Animal Science and Veterinary Medicine, Shanghai Key Laboratory of Agricultural Genetics and Breeding, Shanghai Academy of Agricultural Sciences, Shanghai, 201106, China, Shanghai Engineering Research Center of Breeding Pig, Shanghai, 201106, China; Dong, S., Institute of Animal Science and Veterinary Medicine, Shanghai Key Laboratory of Agricultural Genetics and Breeding, Shanghai Academy of Agricultural Sciences, Shanghai, 201106, China, Shanghai Engineering Research Center of Breeding Pig, Shanghai, 201106, China; Yu, R., Institute of Animal Science and Veterinary Medicine, Shanghai Key Laboratory of Agricultural Genetics and Breeding, Shanghai Academy of Agricultural Sciences, Shanghai, 201106, China, Shanghai Engineering Research Center of Breeding Pig, Shanghai, 201106, China; Li, Z., Institute of Animal Science and Veterinary Medicine, Shanghai Key Laboratory of Agricultural Genetics and Breeding, Shanghai Academy of Agricultural Sciences, Shanghai, 201106, China, Shanghai Engineering Research Center of Breeding Pig, Shanghai, 201106, China","The genomes of coronaviruses carry accessory genes known to be associated with viral virulence. The single accessory gene of porcine epidemic diarrhea virus (PEDV), ORF3, is dispensable for virus replication in vitro, while viral mutants carrying ORF3 truncations exhibit an attenuated phenotype of which the underlying mechanism is unknown. Here, we studied the effect of ORF3 deletion on the proliferation of PEDV in Vero cells. To this end, four recombinant porcine epidemic diarrhea viruses (PEDVs) were rescued using targeted RNA recombination, three carrying the full-length ORF3 gene from different PEDV strains, and one from which the ORF3 gene had been deleted entirely. Our results showed that PEDVs with intact or naturally truncated ORF3 replicated to significantly higher titers than PEDV without an ORF3. Further characterization revealed that the extent of apoptosis induced by PEDV infection was significantly lower with the viruses carrying an intact or C-terminally truncated ORF3 than with the virus lacking ORF3, indicating that the ORF3 protein as well as its truncated form interfered with the apoptosis process. Collectively, we conclude that PEDV ORF3 protein promotes virus proliferation by inhibiting cell apoptosis caused by virus infection. Our findings provide important insight into the role of ORF3 protein in the pathogenicity of PEDV. © 2020 by the authors.",Apoptosis; Cells; PEDV; Proliferation; The role of ORF3,,"Wood, E.N., An apparently new syndrome of porcine epidemic diarrhoea (1977) Vet. Rec., 100, pp. 243-244; Pensaert, M.B., de Bouck, P., A new coronavirus-like particle associated with diarrhea in swine (1978) Arch. Virol., 58, pp. 243-247; Takahashi, K., Okada, K., Ohshima, K., An outbreak of swine diarrhea of a new-type associated with coronavirus-like particles in Japan (1983) Nihon Juigaku Zasshi, 45, pp. 829-832; Song, D., Park, B., Porcine epidemic diarrhoea virus: A comprehensive review of molecular epidemiology, diagnosis, and vaccines (2012) Virus Genes, 44, pp. 167-175; Sun, R.Q., Cai, R.J., Chen, Y.Q., Liang, P.S., Chen, D.K., Song, C.X., Outbreak of porcine epidemic diarrhea in suckling piglets, China (2012) Emerg. Infect. Dis., 18, pp. 161-163; Stevenson, G.W., Hoang, H., Schwartz, K.J., Burrough, E.R., Sun, D., Madson, D., Cooper, V.L., Schmitt, B.J., Emergence of Porcine epidemic diarrhea virus in the United States: Clinical signs, lesions, and viral genomic sequences (2013) J. Vet. Diagn. Invest., 25, pp. 649-654; Kocherhans, R., Bridgen, A., Ackermann, M., Tobler, K., Completion of the porcine epidemic diarrhoea coronavirus (PEDV) genome sequence (2001) Virus Genes, 23, pp. 137-144; Duarte, M., Tobler, K., Bridgen, A., Rasschaert, D., Ackermann, M., Laude, H., Sequence analysis of the porcine epidemic diarrhea virus genome between the nucleocapsid and spike protein genes reveals a polymorphic ORF (1994) Virology, 198, pp. 466-476; Wang, K., Xie, S., Sun, B., Viral proteins function as ion channels (2011) Biochim. Biophys. Acta Biomembr., 1808, pp. 510-515; Tang, X.C., Zhang, J.X., Zhang, S.Y., Wang, P., Fan, X.H., Li, L.F., Li, G., Cheung, C.L., Prevalence and genetic diversity of coronaviruses in bats from China (2006) J. Virol., 80, pp. 7481-7490; Park, S.J., Moon, H.J., Luo, Y., Kim, H.K., Kim, E.M., Yang, J.S., Song, D.S., Park, B.K., Cloning and further sequence analysis of the ORF3 gene of wild- And attenuated-type porcine epidemic diarrhea viruses (2008) Virus Genes, 36, pp. 95-104; Chen, J., Wang, C., Shi, H., Qiu, H., Liu, S., Chen, X., Zhang, Z., Feng, L., Molecular epidemiology of porcine epidemic diarrhea virus in China (2010) Arch. Virol., 155, pp. 1471-1476; Jengarn, J., Wongthida, P., Wanasen, N., Frantz, P.N., Wanitchang, A., Jongkaewwattana, A., Genetic manipulation of porcine epidemic diarrhoea virus recovered from a full-length infectious cDNA clone (2015) J. Gen. Virol., 96, pp. 2206-2218. , CrossRef PubMed; Sun, M., Ma, J., Yu, Z., Pan, Z., Lu, C., Yao, H., Identification of two mutation sites in spike and envelope proteins mediating optimal cellular infection of porcine epidemic diarrhea virus from different pathways (2017) Vet. Res., 48, p. 44. , CrossRef PubMed; Chen, X., Zeng, L., Yang, J., Yu, F., Ge, J., Guo, Q., Gao, X., Song, T., Sequence heterogeneity of the ORF3 gene of porcine epidemic diarrhea viruses field samples in Fujian, China, 2010–2012 (2013) Viruses, 5, pp. 2375-2383. , CrossRef PubMed; Wang, K., Lu, W., Chen, J., Xie, S., Shi, H., Hsu, H., Yu, W., Fischer, W.B., PEDV ORF3 encodes an ion channel protein and regulates virus production (2012) FEBS Lett, 586, pp. 384-391. , CrossRef PubMed; Ye, S., Li, Z., Chen, F., Li, W., Guo, X., Hu, H., He, Q., Porcine epidemic diarrhea virus ORF3 gene prolongs S-phase, facilitates formation of vesicles and promotes the proliferation of attenuated PEDV (2015) Virus Genes, 51, pp. 385-392. , CrossRef PubMed; Kaewborisuth, C., He, Q., Jongkaewwattana, A., The accessory protein ORF3 contributes to porcine epidemic diarrhea virus replication by direct binding to the spike protein (2018) Viruses, 10, p. 399; Xiong, A.-S., Yao, Q.-H., Peng, R.-H., Duan, H., Li, X., Fan, H.-Q., Cheng, Z.-M., Li, Y., PCR-based accurate synthesis of long DNA sequences (2006) Nat. Protoc., 1, pp. 791-797; Li, C., Li, Z., Zou, Y., Wicht, O., van Kuppeveld, F.J., Rottier, P.J., Bosch, B.J., Manipulation of the porcine epidemic diarrhea virus genome using targeted RNA recombination (2013) PLoS ONE, 8; Kim, Y., Lee, C., Porcine epidemic diarrhea virus induces caspase-independent apoptosis through activation of mitochondrial apoptosis-inducing factor (2014) Virology, 460, pp. 180-193; Yuan, J., Shaham, S., Ledoux, S., Ellis, H.M., Horvitz, H.R., The C. Elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme (1993) Cell, 75, pp. 641-652; Porter, A.G., Janicke, R.U., Emerging roles of caspase-3 in apoptosis (1999) Cell Death Differ, 6, pp. 99-104; Chen, Y., Zhang, Z., Li, J., Gao, Y., Zhou, L., Ge, X., Han, J., Yang, H., Porcine epidemic diarrhea virus S1 protein is the critical inducer of apoptosis (2018) Virol. J., 15, p. 170; Xu, X., Xu, Y., Zhang, Q., Yang, F., Yin, Z., Wang, L., Li, Q., Porcine epidemic diarrhea virus infections induce apoptosis in Vero cells via a reactive oxygen species (ROS)/p53, but not p38 MAPK and SAPK/JNK signalling pathways (2019) Vet. Microbiol., 232, pp. 1-12; Thomson, B.J., Viruses and apoptosis (2001) Int. J. Exp. Pathol., 82, pp. 65-76; Ren, L., Yang, R., Guo, L., Qu, J., Wang, J., Hung, T., Apoptosis induced by the SARS-associated coronavirus in Vero cells is replication-dependent and involves caspase (2005) DNA Cell Biol, 24, pp. 496-502; Zhao, X., Song, X., Bai, X., Fei, N., Huang, Y., Zhao, Z., Du, Q., Tong, D., MiR-27b attenuates apoptosis induced by transmissible gastroenteritis virus (TGEV) infection via targeting runt-related transcription factor 1 (RUNX1) (2016) PeerJ, 4; Zhang, Q., Ma, J., Yoo, D., Inhibition of NF-kappaB activity by the porcine epidemic diarrhea virus nonstructural protein 1 for innate immune evasion (2017) Virology, 510, pp. 111-126; Wongthida, P., Liwnaree, B., Wanasen, N., Narkpuk, J., Jongkaewwattana, A., The role of ORF3 accessory protein in replication of cell-adapted porcine epidemic diarrhea virus (PEDV) (2017) Arch. Virol., 162, pp. 2553-2563; Kaewborisuth, C., Yingchutrakul, Y., Roytrakul, S., Jongkaewwattana, A., Porcine epidemic diarrhea virus (PEDV) ORF3 interactome reveals inhibition of virus replication by cellular VPs36 protein (2019) Viruses, 11, p. 382","Li, Z.; Institute of Animal Science and Veterinary Medicine, Shanghai Key Laboratory of Agricultural Genetics and Breeding, Shanghai Academy of Agricultural SciencesChina; email: zhenli60@163.com",,MDPI AG,19994915,,,32075094,English,Viruses,Article,Final,Open Access,Scopus,2-s2.0-85079793415,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Carter D.C., Wright B., Jerome W.G., Rose J.P., Wilson E.",57199375399;57214829812;35586898500;57203667106;57213822050;,A Unique Protein Self-Assembling Nanoparticle with Significant Advantages in Vaccine Development and Production,2020,Journal of Nanomaterials,2020,,4297937,,,,,10.1155/2020/4297937,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077990739&doi=10.1155%2f2020%2f4297937&partnerID=40&md5=f940dbb5940f19abd0d2bfe804690f59,"Albumin Therapeutics, LLC, 895 Martin Road SW, Huntsville, AL, United States; New Century Pharmaceuticals Inc., 895 Martin Road SW, Huntsville, United States; Vanderbilt University, Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, U2206 MCN, 1161 21st Ave., South, Nashville, TN, United States; University of Georgia, Department of Biochemistry and Molecular Biology, 120 Green St., Athens, GA, United States","Carter, D.C., Albumin Therapeutics, LLC, 895 Martin Road SW, Huntsville, AL, United States, New Century Pharmaceuticals Inc., 895 Martin Road SW, Huntsville, United States; Wright, B., Albumin Therapeutics, LLC, 895 Martin Road SW, Huntsville, AL, United States; Jerome, W.G., Vanderbilt University, Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, U2206 MCN, 1161 21st Ave., South, Nashville, TN, United States; Rose, J.P., University of Georgia, Department of Biochemistry and Molecular Biology, 120 Green St., Athens, GA, United States; Wilson, E., Albumin Therapeutics, LLC, 895 Martin Road SW, Huntsville, AL, United States","Nanoparticles are playing an increasingly powerful role in vaccine development. Here, we report the repurposing of nonstructural proteins 10 and 11 (hereafter NSP10) from the replicase polyprotein 1a (pp1a) of the human SARS coronavirus (severe acute respiratory syndrome) as a novel self-assembling platform for bioengineered nanoparticles for a variety of applications including vaccines. NSP10 represents a 152 amino acid, 17 kD zinc finger transcription/regulatory protein which self-assembles to form a spherical 84 Å diameter nanoparticle with dodecahedral trigonal 32 point symmetry. As a self-assembling nanoparticle, NSP10 possesses numerous advantages in vaccine development and antigen display, including the unusual particle surface disposition of both the N- and C-termini. Each set of N- or C-termini is spatially disposed in a tetrahedral arrangement and positioned at optimal distances from the 3-fold axes (8-10 Å) to nucleate and stabilize the correct folding of complex helical or fibrous trimeric receptors, such as those responsible for viral tropism and cell infection. An application example in the exploratory development of a therapeutic vaccine for idiopathic pulmonary fibrosis (IPF), including preliminary analysis and immunogenic properties, is presented. The use of this system could accelerate the discovery and development of vaccines for a number of human, livestock, and veterinary applications. © 2020 Daniel C. Carter et al.",,Agriculture; Diseases; Nanoparticles; Proteins; Idiopathic pulmonary fibrosis; Immunogenic properties; Nonstructural proteins; Preliminary analysis; Severe acute respiratory syndrome; Tetrahedral arrangement; Veterinary applications; Zinc-finger transcription; Vaccines,"Carter, D.C., Li, C., Genetically engineered ferritin as a vehicle for vaccine production, biomaterials, oxygen transport, and therapeutic delivery U S Patent No. 2006;7,097,841; Kanekiyo, M., Wei, C.J., Yassine, H.M., Self-assembling influenza nanoparticle vaccines elicit broadly neutralizing H1N1 antibodies (2013) Nature, 499 (7456), pp. 102-106; Kanekiyo, M., Bu, W., Joyce, M.G., Rational design of an Epstein-Barr virus vaccine targeting the receptor-binding site (2015) Cell, 162 (5), pp. 1090-1100; Li, C., Soistman, E., Carter, D.C., Ferritin nanoparticle technology: A new platform for antigen presentation and vaccine development (2006) Industrial Biotechnology, 2 (2), pp. 143-147; Wang, Z., Li, C., Ellenburg, M., Structure of human ferritin L chain (2006) Acta Crystallographica. Section D, Biological Crystallography, 62 (7), pp. 800-806; Tokatlian, T., Read, B.J., Jones, C.A., Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers (2019) Science, 363 (6427), pp. 649-654; Cohen, J., A once-in-A-lifetime flu shot? (2013) Science, 341 (6151), p. 1171; Carter, D.C., Nsp10 self-assembling fusion proteins for vaccines, therapeutics, diagnostics and other nanomaterial applications US Application No. 2018;15/768,250; Su, D., Lou, Z., Sun, F., Dodecamer structure of severe acute respiratory syndrome coronavirus nonstructural protein nsp10 (2006) Journal of Virology, 80 (16), pp. 7902-7908; Papanikolopoulou, K., Teixeira, S., Belrhali, H., Forsyth, V.T., Mitraki, A., Van Raaij, M.J., Adenovirus fibre shaft sequences fold into the native triple beta-spiral fold when N-terminally fused to the bacteriophage T4 fibritin foldon trimerisation motif (2004) Journal of Molecular Biology, 342 (1), pp. 219-227; Papanikolopoulou, K., Forge, V., Goeltz, P., Mitraki, A., Formation of highly stable chimeric trimers by fusion of an adenovirus fiber shaft fragment with the foldon domain of bacteriophage t4 fibritin (2004) The Journal of Biological Chemistry, 279 (10), pp. 8991-8998; Folcik, V.A., Garofalo, M., Coleman, J., Idiopathic pulmonary fibrosis is strongly associated with productive infection by herpesvirus saimiri (2014) Modern Pathology, 27 (6), pp. 851-862; Fickenscher, H., Fleckenstein, B., Herpesvirus saimiri (2001) Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 356 (1408), pp. 545-567; Williams, K.J., Gammaherpesviruses and pulmonary fibrosis: Evidence from humans, horses, and rodents (2014) Veterinary Pathology, 51 (2), pp. 372-384; Ma, G., Azab, W., Osterrieder, N., Equine herpesviruses type 1 (EHV-1) and 4 (EHV-4)-masters of co-evolution and a constant threat to equids and beyond (2013) Veterinary Microbiology, 167 (1-2), pp. 123-134; Mora, A.L., Torres-González, E., Rojas, M., Control of virus reactivation arrests pulmonary herpesvirus-induced fibrosis in IFN-gamma receptor-deficient mice (2007) American Journal of Respiratory and Critical Care Medicine, 175 (11), pp. 1139-1150; Lederer, D.J., Martinez, F.J., Idiopathic pulmonary fibrosis (2018) The New England Journal of Medicine, 378 (19), pp. 1811-1823; Collard, H.R., Moore, B.B., Flaherty, K.R., Acute exacerbations of idiopathic pulmonary fibrosis (2007) American Journal of Respiratory and Critical Care Medicine, 176 (7), pp. 636-643; Raghu, G., Collard, H.R., Egan, J.J., An official ats/ers/jrs/alat statement: Idiopathic pulmonary fibrosis: Evidence-based guidelines for diagnosis and management (2011) American Journal of Respiratory and Critical Care Medicine, 183 (6), pp. 788-824; King, T.E., Jr., Bradford, W.Z., Castro-Bernardini, S., A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis (2014) The New England Journal of Medicine, 370 (22), pp. 2083-2092; Richeldi, L., Du Bois, R.M., Raghu, G., Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis (2014) The New England Journal of Medicine, 370 (22), pp. 2071-2082; Olson, A.L., Swigris, J.J., Lezotte, D.C., Norris, J.M., Wilson, C.G., Brown, K.K., Mortality from pulmonary fibrosis increased in the United States from 1992 to 2003 (2007) American Journal of Respiratory and Critical Care Medicine, 176 (3), pp. 277-284; Hensel, M.T., Marshall, J.D., Dorwart, M.R., Prophylactic herpes simplex virus 2 (HSV-2) vaccines adjuvanted with stable emulsion and Toll-like receptor 9 agonist induce a robust HSV-2-specific cell-mediated immune response, protect against symptomatic disease, and reduce the latent viral reservoir (2017) Journal of Virology, 91 (9); Weed, D.J., Nicola, A.V., Herpes simplex virus membrane fusion (2017) Advances in Anatomy, Embryology, and Cell Biology, 223, pp. 29-47; Di Giovine, P., Settembre, E.C., Bhargava, A.K., Structure of herpes simplex virus glycoprotein D bound to the human receptor nectin-1 (2011) PLoS Pathogens, 7 (9); Cairns, T.M., Huang, Z.Y., Gallagher, J.R., Patientspecific neutralizing antibody responses to herpes simplex virus are attributed to epitopes on gD, Gb, or both and can be type specific (2015) Journal of Virology, 89 (18), pp. 9213-9231; Ablashi, D.V., Easton, J.M., Preventive vaccination against Herpesvirus saimiri-induced neoplasia (1976) Cancer Research, 36, pp. 701-703; Tang, Y.W., Johnson, J.E., Browning, P.J., Herpesvirus DNA is consistently detected in lungs of patients with idiopathic pulmonary fibrosis (2003) Journal of Clinical Microbiology, 41 (6), pp. 2633-2640; Zhao, Y., Chang, J., Zhang, B., TLR-5 agonist Salmonella abortus equi flagellin FliC enhances FliC-gD-based DNA vaccination against equine herpesvirus 1 infection (2019) Archives of Virology, 164 (5), pp. 1371-1382; Li, L., Saade, F., Petrovsky, N., The future of human DNA vaccines (2012) Journal of Biotechnology, 162 (2-3), pp. 171-182; Li, L., Petrovsky, N., Molecular mechanisms for enhanced DNA vaccine immunogenicity (2016) Expert Review of Vaccines, 15 (3), pp. 313-329; Li, L., Petrovsky, N., Molecular adjuvants for DNA vaccines (2017) Current Issues in Molecular Biology, 22, pp. 17-40; Awasthi, S., Mahairas, G.G., Shaw, C.E., A dual-modality herpes simplex virus 2 vaccine for preventing genital herpes by using glycoprotein C and D subunit antigens to induce potent antibody responses and adenovirus vectors containing capsid and tegument proteins as T cell immunogens (2015) Journal of Virology, 89 (16), pp. 8497-8509","Carter, D.C.; Albumin Therapeutics, LLC, 895 Martin Road SW, United States; email: dcarter@albuminbio.com",,Hindawi Limited,16874110,,,,English,J. Nanomater.,Article,Final,Open Access,Scopus,2-s2.0-85077990739,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Hoang V.-T., Sow D., Belhouchat K., Dao T.-L., Ly T.D.A., Fenollar F., Yezli S., Alotaibi B., Raoult D., Parola P., Pommier de Santi V., Gautret P.",57202332027;6603822766;55607871900;57208530490;57196149513;6701729152;35996197300;55393168700;57208853524;7006212186;26429906300;36893462000;,Environmental investigation of respiratory pathogens during the Hajj 2016 and 2018,2020,Travel Medicine and Infectious Disease,33,,101500,,,,,10.1016/j.tmaid.2019.101500,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85074426209&doi=10.1016%2fj.tmaid.2019.101500&partnerID=40&md5=d6e8882f63ac09e887d55326ca33d554,"Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France; IHU-Méditerranée Infection, Marseille, France; Thai Binh University of Medicine and Pharmacy, Thai Binh, Viet Nam; Service de Parasitologie-Mycologie, Faculté de médecine, Université Cheikh Anta Diop, Dakar, Senegal; The Global Centre for Mass Gatherings Medicine, Ministry of Health, Riyadh, Saudi Arabia; Aix Marseille Univ, MEPHI, Marseille, France; French Military Center for Epidemiology and Public Health Marseille, France","Hoang, V.-T., Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France, IHU-Méditerranée Infection, Marseille, France, Thai Binh University of Medicine and Pharmacy, Thai Binh, Viet Nam; Sow, D., Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France, IHU-Méditerranée Infection, Marseille, France, Service de Parasitologie-Mycologie, Faculté de médecine, Université Cheikh Anta Diop, Dakar, Senegal; Belhouchat, K., Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France, IHU-Méditerranée Infection, Marseille, France; Dao, T.-L., Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France, IHU-Méditerranée Infection, Marseille, France, Thai Binh University of Medicine and Pharmacy, Thai Binh, Viet Nam; Ly, T.D.A., Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France, IHU-Méditerranée Infection, Marseille, France; Fenollar, F., Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France, IHU-Méditerranée Infection, Marseille, France; Yezli, S., The Global Centre for Mass Gatherings Medicine, Ministry of Health, Riyadh, Saudi Arabia; Alotaibi, B., The Global Centre for Mass Gatherings Medicine, Ministry of Health, Riyadh, Saudi Arabia; Raoult, D., IHU-Méditerranée Infection, Marseille, France, Aix Marseille Univ, MEPHI, Marseille, France; Parola, P., Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France, IHU-Méditerranée Infection, Marseille, France; Pommier de Santi, V., Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France, IHU-Méditerranée Infection, Marseille, France, French Military Center for Epidemiology and Public Health Marseille, France; Gautret, P., Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, Marseille, France, IHU-Méditerranée Infection, Marseille, France","Background: Respiratory tract infections are common in the context of the Hajj pilgrimage and respiratory pathogens can be transmitted via contact with contaminated surfaces. We sampled surfaces during the Hajj to detect the presence of respiratory bacteria and viruses. Methods: Frequently touched surfaces at Mecca, Mina, Arafat and Medina were sampled. The common respiratory pathogens were tested by qPCR. Results: 70/142 (49.3%) environmental samples collected were positive for at least one respiratory pathogen. Among the positive samples, Klebsiella pneumoniae was the bacterium most frequently tested positive (57.1%), followed by Streptococcus pneumoniae (12.9%), Staphylococcus aureus (10.0%) and Haemophilus influenzae (7.1%). 32.9% positive samples tested positive for rhinovirus and 1.4% for coronavirus. Surfaces with the highest rates of positive samples were kitchen tables (100%), water fountain faucet (73.3%) and edge of water coolers lid (84.6%). Samples collected in Mina were the most frequently contaminated with 68.8% being positive for at least one pathogen and 18.8% positive for a combination of multiple pathogens. Conclusion: These preliminary results indicate that respiratory pathogens are common in environmental surfaces from areas frequented by Hajj pilgrims. Further larger-scale studies are needed to better assess the possible role of environmental respiratory pathogens in respiratory infections in Hajj pilgrims. © 2019 Elsevier Ltd",Environmental sampling; Hajj; Human rhinovirus; Klebsiella pneumoniae; Respiratory pathogens; Streptococcus pneumoniae,water; Article; controlled study; Coronavirinae; Haemophilus influenzae; Human rhinovirus; Klebsiella pneumoniae; microbial contamination; nonhuman; priority journal; real time polymerase chain reaction; respiratory tract infection; Staphylococcus aureus; Streptococcus pneumoniae,"Memish, Z.A., Zumla, A., Alhakeem, R.F., Hajj: infectious disease surveillance and control (2014) Lancet, 383, pp. 2073-2082; Madani, T.A., Ghabrah, T.M., Al-Hedaithy, M.A., Causes of hospitalization of pilgrims in the Hajj season of the Islamic year 1423 (2003) (2006) Ann Saudi Med, 26, pp. 346-351; Al-Orainey, I.O., Tuberculosis infection during Hajj pilgrimage (2013) Saudi Med J, 34, pp. 676-680; Hoang, V.T., Gautret, P., Infectious diseases and mass gatherings (2018) Curr Infect Dis Rep, 20, p. 44; Gautret, P., Benkouiten, S., Al-Tawfiq, J.A., Memish, Z.A., Hajj-associated viral respiratory infections: a systematic review (2016) Trav Med Infect Dis, 14, pp. 92-109; Al-Tawfiq, J.A., Benkouiten, S., Memish, Z.A., A systematic review of emerging respiratory viruses at the Hajj and possible coinfection with Streptococcus pneumoniae (2018) Trav Med Infect Dis, 23, pp. 6-13; Hoang, V.T., Meftah, M., Anh Ly, T.D., Drali, T., Yezli, S., Alotaibi, B., Bacterial respiratory carriage in French Hajj pilgrims and the effect of pneumococcal vaccine and other individual preventive measures: a prospective cohort survey (2018) Trav Med Infect Dis; Khamis, N.K., Epidemiological pattern of diseases and risk behaviors of pilgrims attending Mina hospitals, Hajj 1427 H (2007 G) (2008) J Egypt Public Health Assoc, 83, pp. 15-33; Abubakar, I., Gautret, P., Brunette, G.W., Blumberg, L., Johnson, D., Poumerol, G., Global perspectives for prevention of infectious diseases associated with mass gatherings (2012) Lancet Infect Dis, 12, pp. 66-74; Al-Tawfiq, J.A., Zumla, A., Memish, Z.A., Respiratory tract infections during the annual Hajj: potential risks and mitigation strategies (2013) Curr Opin Pulm Med, 19, pp. 192-197; Yezli, S., Memish, Z.A., Tuberculosis in Saudi Arabia: prevalence and antimicrobial resistance (2012) J Chemother, 24, pp. 1-5; Otter, J.A., Yezli, S., French, G.L., The role played by contaminated surfaces in the transmission of nosocomial pathogens (2011) Infect Control Hosp Epidemiol, 32, pp. 687-699; Fernstrom, A., Goldblatt, M., Aerobiology and its role in the transmission of infectious diseases (2013) J Pathog, 2013. , 493960; La Rosa, G., Fratini, M., Della Libera, S., Iaconelli, M., Muscillo, M., Viral infections acquired indoors through airborne, droplet or contact transmission (2013) Ann Ist Super Sanita, 49, pp. 124-132; Hoang, V.T., Sow, D., Dogue, F., Edouard, S., Drali, T., Yezli, S., Acquisition of respiratory viruses and presence of respiratory symptoms in French pilgrims during the 2016 Hajj: a prospective cohort study (2019) Trav Med Infect Dis; Memish, Z.A., Assiri, A., Turkestani, A., Yezli, S., Al Masri, M., Charrel, R., Mass gathering and globalization of respiratory pathogens during the 2013 Hajj (2015) Clin Microbiol Infect, 21. , 571.e1-8; Ninove, N., Nougairede, A., Gazin, C., Thirion, L., Delogu, I., Zandotti, C., RNA and DNA bacteriophages as molecular diagnosis controls in clinical virology: a comprehensive study of more than 45,000 routine PCR tests (2011) PLoS One, 6; Boone, S.A., Gerba, C.P., Significance of fomites in the spread of respiratory and enteric viral disease (2007) Appl Environ Microbiol, 73, pp. 1687-1696; Weber, D.J., Anderson, D., Rutala, W.A., The role of the surface environment in healthcare-associated infections (2013) Curr Opin Infect Dis, 26, pp. 338-344; Kramer, A., Schwebke, I., Kampf, G., How long do nosocomial pathogens persist on inanimate surfaces? A systematic review (2006) BMC Infect Dis, 6, p. 130; Walther, B.A., Ewald, P.W., Pathogen survival in the external environment and the evolution of virulence (2004) Biol Rev Camb Philos Soc, 79, pp. 849-869; Angelakis, E., Yasir, M., Azhar, E.I., Papadioti, A., Bibi, F., Aburizaiza, A.S., MALDI-TOF mass spectrometry and identification of new bacteria species in air samples from Makkah, Saudi Arabia (2014) BMC Res Notes, 7, p. 892; Memish, Z.A., Almasri, M., Assirri, A., Al-Shangiti, A.M., Gray, G.C., Lednicky, J.A., Environmental sampling for respiratory pathogens in Jeddah airport during the 2013 Hajj season (2014) Am J Infect Contr, 42, pp. 1266-1269; Hoang, V.T., Sow, D., Dogue, F., Edouard, S., Drali, T., Yezli, S., Acquisition of respiratory viruses and presence of respiratory symptoms in French pilgrims during the 2016 Hajj: a prospective cohort study (2019) Trav Med Infect Dis; Afifi, M.M., Detection of extended spectrum beta-lactamase producing Klebsiella pneumoniae and Escherichia coli of environmental surfaces at upper Egypt (2013) Int J Biol Chem, 7, pp. 58-68; Zafar, M.A., Wang, Y., Hamaguchi, S., Weiser, J.N., Host-to-Host Transmission of Streptococcus pneumoniae is driven by its inflammatory toxin, Pneumolysin (2017) Cell Host Microbe, 21, pp. 73-83; Givon-Lavi, N., Fraser, D., Porat, N., Dagan, R., Spread of Streptococcus pneumoniae and antibiotic-resistant S. pneumoniae from day-care center attendees to their younger siblings (2002) J Infect Dis, 186, pp. 1608-1614; Bogaert, D., De Groot, R., Hermans, P.W., Streptococcus pneumoniae colonisation: the key to pneumococcal disease (2004) Lancet Infect Dis, pp. 144-154; Yezli, S., Otter, J.A., Minimum infective dose of the major human respiratory and enteric viruses transmitted through food and the environment (2011) Food Environ Virol, 3, pp. 1-30; van Doremalen, N., Bushmaker, T., Munster, V.J., Stability of Middle East respiratory syndrome coronavirus (MERS-CoV) under different environmental conditions (2013) Euro Surveill, 18; Dowell, S.F., Simmerman, J.M., Erdman, D.D., Wu, J.S., Chaovavanich, A., Javadi, M., Severe acute respiratory syndrome coronavirus on hospital surfaces (2004) Clin Infect Dis, 39, pp. 652-657; Winther, B., McCue, K., Ashe, K., Rubino, J.R., Hendley, J.O., Environmental contamination with rhinovirus and transfer to fingers of healthy individuals by daily life activity (2007) J Med Virol, 79, pp. 1606-1610; Ikonen, N., Savolainen-Kopra, C., Enstone, J.E., Kulmala, I., Pasanen, P., Salmela, A., Deposition of respiratory virus pathogens on frequently touched surfaces at airports (2018) BMC Infect Dis, 18, p. 437; Killingley, B., Greatorex, J., Digard, P., Wise, H., Garcia, F., Varsani, H., The environmental deposition of influenza virus from patients infected with influenza A(H1N1)pdm09: implications for infection prevention and control (2016) J Infect Public Health, 9, pp. 278-288","Gautret, P.; VITROME, Institut Hospitalo-Universitaire Méditerranée Infection, 19-21, Boulevard Jean Moulin, France; email: philippe.gautret@ap-hm.fr",,Elsevier USA,14778939,,TMIDA,31600567,English,Travel Med. Infect. Dis.,Article,Final,Open Access,Scopus,2-s2.0-85074426209,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Shen C., Wang Z., Zhao F., Yang Y., Li J., Yuan J., Wang F., Li D., Yang M., Xing L., Wei J., Xiao H., Yang Y., Qu J., Qing L., Chen L., Xu Z., Peng L., Li Y., Zheng H., Chen F., Huang K., Jiang Y., Liu D., Zhang Z., Liu Y., Liu L.",57215934081;57214896826;57215934898;57215544192;57214899559;57215935445;57214893775;57215931440;57216101196;57215935671;57215931944;57215931959;57215938186;57215935074;57215932558;57203143511;57215931753;57207695610;57215937913;57215934040;57207689153;57215931490;57215933767;57215933460;8965136800;7410218226;57190174032;,Treatment of 5 Critically Ill Patients with COVID-19 with Convalescent Plasma,2020,JAMA - Journal of the American Medical Association,,,,,,,1,10.1001/jama.2020.4783,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082418248&doi=10.1001%2fjama.2020.4783&partnerID=40&md5=992922002868bd323b2c5c0d95a08bed,"Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, No. 29, Bulan Road, Longgang District, Shenzhen, 518112, China; Laboratory of Protein Engineering and Vaccines, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences (CAS), Tianjin, China","Shen, C., Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, No. 29, Bulan Road, Longgang District, Shenzhen, 518112, China; Wang, Z., Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, No. 29, Bulan Road, Longgang District, Shenzhen, 518112, China; Zhao, F., Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, No. 29, Bulan Road, Longgang District, Shenzhen, 518112, China; Yang, Y., Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, No. 29, Bulan Road, Longgang District, Shenzhen, 518112, China; Li, J., Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, No. 29, Bulan Road, Longgang District, Shenzhen, 518112, China; Yuan, J., Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, No. 29, Bulan Road, Longgang District, Shenzhen, 518112, China; Wang, F., Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, No. 29, Bulan Road, Longgang District, Shenzhen, 518112, China; Li, D., Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, No. 29, Bulan Road, Longgang District, Shenzhen, 518112, China, Laboratory of Protein Engineering and Vaccines, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences (CAS), Tianjin, China; Yang, M., Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, No. 29, Bulan Road, Longgang District, Shenzhen, 518112, China; Xing, L., Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, No. 29, Bulan Road, Longgang District, Shenzhen, 518112, China; Wei, J., Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, No. 29, Bulan Road, Longgang District, Shenzhen, 518112, China; Xiao, H., Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, No. 29, Bulan Road, Longgang District, Shenzhen, 518112, China, Laboratory of Protein Engineering and Vaccines, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences (CAS), Tianjin, China; Yang, Y., Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, No. 29, Bulan Road, Longgang District, Shenzhen, 518112, China; Qu, J., Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, No. 29, Bulan Road, Longgang District, Shenzhen, 518112, China; Qing, L., Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, No. 29, Bulan Road, Longgang District, Shenzhen, 518112, China; Chen, L., Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, No. 29, Bulan Road, Longgang District, Shenzhen, 518112, China; Xu, Z., Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, No. 29, Bulan Road, Longgang District, Shenzhen, 518112, China; Peng, L., Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, No. 29, Bulan Road, Longgang District, Shenzhen, 518112, China; Li, Y., Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, No. 29, Bulan Road, Longgang District, Shenzhen, 518112, China; Zheng, H., Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, No. 29, Bulan Road, Longgang District, Shenzhen, 518112, China; Chen, F., Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, No. 29, Bulan Road, Longgang District, Shenzhen, 518112, China; Huang, K., Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, No. 29, Bulan Road, Longgang District, Shenzhen, 518112, China; Jiang, Y., Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, No. 29, Bulan Road, Longgang District, Shenzhen, 518112, China; Liu, D., Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, No. 29, Bulan Road, Longgang District, Shenzhen, 518112, China; Zhang, Z., Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, No. 29, Bulan Road, Longgang District, Shenzhen, 518112, China; Liu, Y., Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, No. 29, Bulan Road, Longgang District, Shenzhen, 518112, China; Liu, L., Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, No. 29, Bulan Road, Longgang District, Shenzhen, 518112, China","Importance: Coronavirus disease 2019 (COVID-19) is a pandemic with no specific therapeutic agents and substantial mortality. It is critical to find new treatments. Objective: To determine whether convalescent plasma transfusion may be beneficial in the treatment of critically ill patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Design, Setting, and Participants: Case series of 5 critically ill patients with laboratory-confirmed COVID-19 and acute respiratory distress syndrome (ARDS) who met the following criteria: severe pneumonia with rapid progression and continuously high viral load despite antiviral treatment; Pao2/Fio2 <300; and mechanical ventilation. All 5 were treated with convalescent plasma transfusion. The study was conducted at the infectious disease department, Shenzhen Third People's Hospital in Shenzhen, China, from January 20, 2020, to March 25, 2020; final date of follow-up was March 25, 2020. Clinical outcomes were compared before and after convalescent plasma transfusion. Exposures: Patients received transfusion with convalescent plasma with a SARS-CoV-2-specific antibody (IgG) binding titer greater than 1:1000 (end point dilution titer, by enzyme-linked immunosorbent assay [ELISA]) and a neutralization titer greater than 40 (end point dilution titer) that had been obtained from 5 patients who recovered from COVID-19. Convalescent plasma was administered between 10 and 22 days after admission. Main Outcomes and Measures: Changes of body temperature, Sequential Organ Failure Assessment (SOFA) score (range 0-24, with higher scores indicating more severe illness), Pao2/Fio2, viral load, serum antibody titer, routine blood biochemical index, ARDS, and ventilatory and extracorporeal membrane oxygenation (ECMO) supports before and after convalescent plasma transfusion. Results: All 5 patients (age range, 36-65 years; 2 women) were receiving mechanical ventilation at the time of treatment and all had received antiviral agents and methylprednisolone. Following plasma transfusion, body temperature normalized within 3 days in 4 of 5 patients, the SOFA score decreased, and Pao2/Fio2 increased within 12 days (range, 172-276 before and 284-366 after). Viral loads also decreased and became negative within 12 days after the transfusion, and SARS-CoV-2-specific ELISA and neutralizing antibody titers increased following the transfusion (range, 40-60 before and 80-320 on day 7). ARDS resolved in 4 patients at 12 days after transfusion, and 3 patients were weaned from mechanical ventilation within 2 weeks of treatment. Of the 5 patients, 3 have been discharged from the hospital (length of stay: 53, 51, and 55 days), and 2 are in stable condition at 37 days after transfusion. Conclusions and Relevance: In this preliminary uncontrolled case series of 5 critically ill patients with COVID-19 and ARDS, administration of convalescent plasma containing neutralizing antibody was followed by improvement in their clinical status. The limited sample size and study design preclude a definitive statement about the potential effectiveness of this treatment, and these observations require evaluation in clinical trials.. © 2020 American Medical Association. All rights reserved.",,,"Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395 (10223), pp. 497-506. , 31986264; (2020) Novel Coronavirus (COVID-19) Situation, , https://experience.arcgis.com/experience/685d0ace521648f8a5beeeee1b9125cd, Updated March 24; Wu, Z., McGoogan, J.M., Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a report of 72314 cases from the Chinese Center for Disease Control and Prevention (2020) JAMA, , http://jamanetwork.com/article.aspx?doi=10.1001/jama.2020.2648, Published online February 24, 2020. doi: PMID 32091533; Lu, H., Drug treatment options for the 2019-new coronavirus (2019-nCoV) (2020) Biosci Trends, 14 (1), pp. 69-71. , PMID 31996494; Chen, L., Xiong, J., Bao, L., Shi, Y., Convalescent plasma as a potential therapy for COVID-19 (2020) Lancet Infect Dis, , S1473-3099(20)30141-9. PMID 32113510; Kraft, C.S., Hewlett, A.L., Koepsell, S., The use of TKM-100802 and convalescent plasma in 2 patients with Ebola virus disease in the United States (2015) Clin Infect Dis, 61 (4), pp. 496-502. , PMID 25904375; Van Griensven, J., Edwards, T., De Lamballerie, X., Evaluation of convalescent plasma for Ebola virus disease in Guinea (2016) N Engl J Med, 374 (1), pp. 33-42. , PMID 26735992; Florescu, D.F., Kalil, A.C., Hewlett, A.L., Administration of brincidofovir and convalescent plasma in a patient with Ebola virus disease (2015) Clin Infect Dis, 61 (6), pp. 969-973. , PMID 25991468; Zhou, B., Zhong, N., Guan, Y., Treatment with convalescent plasma for influenza A (H5N1) infection (2007) N Engl J Med, 357 (14), pp. 1450-1451. , PMID 17914053; Hung, I.F., To, K.K., Lee, C.K., Convalescent plasma treatment reduced mortality in patients with severe pandemic influenza A (H1N1) 2009 virus infection (2011) Clin Infect Dis, 52 (4), pp. 447-456. , PMID 21248066; Burnouf, T., Radosevich, M., Treatment of severe acute respiratory syndrome with convalescent plasma (2003) Hong Kong Med J, 9 (4), p. 309. , PMID 12904626; Cheng, Y., Wong, R., Soo, Y.O., Use of convalescent plasma therapy in SARS patients in Hong Kong (2005) Eur J Clin Microbiol Infect Dis, 24 (1), pp. 44-46. , PMID 15616839; Yang, Y., Yang, M., Shen, C., (2020) Evaluating the Accuracy of Different Respiratory Specimens in the Laboratory Diagnosis and Monitoring the Viral Shedding of 2019-nCoV Infections, , http://dx.doi.org/10.1101/2020.02.11.20021493, Preprint. medRxiv. 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Preprint posted online March 5; Yeh, K.M., Chiueh, T.S., Siu, L.K., Experience of using convalescent plasma for severe acute respiratory syndrome among healthcare workers in a Taiwan hospital (2005) J Antimicrob Chemother, 56 (5), pp. 919-922. , PMID 16183666; Mair-Jenkins, J., Saavedra-Campos, M., Baillie, J.K., The effectiveness of convalescent plasma and hyperimmune immunoglobulin for the treatment of severe acute respiratory infections of viral etiology: A systematic review and exploratory meta-analysis (2015) J Infect Dis, 211 (1), pp. 80-90. , PMID 25030060; Ng, K.T., Oong, X.Y., Lim, S.H., Viral load and sequence analysis reveal the symptom severity, diversity, and transmission clusters of rhinovirus infections (2018) Clin Infect Dis, 67 (2), pp. 261-268. , PMID 29385423; De Jong, M.D., Simmons, C.P., Thanh, T.T., Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia (2006) Nat Med, 12 (10), pp. 1203-1207. , PMID 16964257; Shen, C., Chen, J., Li, R., A multimechanistic antibody targeting the receptor binding site potently cross-protects against influenza B viruses (2017) Sci Transl Med, 9 (412). , eaam5752. PMID 29046433; Shen, C., Zhang, M., Chen, Y., An IgM antibody targeting the receptor binding site of influenza B blocks viral infection with great breadth and potency (2019) Theranostics, 9 (1), pp. 210-231. , PMID 30662563; Wang, C., Li, W., Drabek, D., (2020) A Human Monoclonal Antibody Blocking SARS-CoV-2 Infection, , http://dx.doi.org/10.1101/2020.03.11.987958, bioRxiv. Preprint posted online March 12; Lu, C.L., Murakowski, D.K., Bournazos, S., Enhanced clearance of HIV-1-infected cells by broadly neutralizing antibodies against HIV-1 in vivo (2016) Science, 352 (6288), pp. 1001-1004. , PMID 27199430","Zhang, Z.; Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, No. 29, Bulan Road, China; email: zhangzheng1975@aliyun.com",,American Medical Association,987484,,JAMAA,,English,JAMA,Article,Article in Press,Open Access,Scopus,2-s2.0-85082418248,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wong J., Goh Q.Y., Tan Z., Lie S.A., Tay Y.C., Ng S.Y., Soh C.R.",57158128600;57207983227;57210581637;57196149976;57215771196;37122594400;7102818768;,Preparing for a COVID-19 pandemic: a review of operating room outbreak response measures in a large tertiary hospital in Singapore [Se préparer pour la pandémie de COVID-19: revue des moyens déployés dans un bloc opératoire d’un grand hôpital tertiaire au Singapour],2020,Canadian Journal of Anesthesia,,,,,,,,10.1007/s12630-020-01620-9,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081896575&doi=10.1007%2fs12630-020-01620-9&partnerID=40&md5=e23bee164e4084ddc07f0cfaca46baf4,"Division of Anaesthesiology, Singapore General Hospital, Outram Road, Singapore, 169608, Singapore","Wong, J., Division of Anaesthesiology, Singapore General Hospital, Outram Road, Singapore, 169608, Singapore; Goh, Q.Y., Division of Anaesthesiology, Singapore General Hospital, Outram Road, Singapore, 169608, Singapore; Tan, Z., Division of Anaesthesiology, Singapore General Hospital, Outram Road, Singapore, 169608, Singapore; Lie, S.A., Division of Anaesthesiology, Singapore General Hospital, Outram Road, Singapore, 169608, Singapore; Tay, Y.C., Division of Anaesthesiology, Singapore General Hospital, Outram Road, Singapore, 169608, Singapore; Ng, S.Y., Division of Anaesthesiology, Singapore General Hospital, Outram Road, Singapore, 169608, Singapore; Soh, C.R., Division of Anaesthesiology, Singapore General Hospital, Outram Road, Singapore, 169608, Singapore","The coronavirus disease 2019 (COVID-19) outbreak has been designated a public health emergency of international concern. To prepare for a pandemic, hospitals need a strategy to manage their space, staff, and supplies so that optimum care is provided to patients. In addition, infection prevention measures need to be implemented to reduce in-hospital transmission. In the operating room, these preparations involve multiple stakeholders and can present a significant challenge. Here, we describe the outbreak response measures of the anesthetic department staffing the largest (1,700-bed) academic tertiary level acute care hospital in Singapore (Singapore General Hospital) and a smaller regional hospital (Sengkang General Hospital). These include engineering controls such as identification and preparation of an isolation operating room, administrative measures such as modification of workflow and processes, introduction of personal protective equipment for staff, and formulation of clinical guidelines for anesthetic management. Simulation was valuable in evaluating the feasibility of new operating room set-ups or workflow. We also discuss how the hierarchy of controls can be used as a framework to plan the necessary measures during each phase of a pandemic, and review the evidence for the measures taken. These containment measures are necessary to optimize the quality of care provided to COVID-19 patients and to reduce the risk of viral transmission to other patients or healthcare workers. © 2020, Canadian Anesthesiologists' Society.",,,"(2005) Emergency Committee regarding the Outbreak of Novel Coronavirus (2019-Ncov), , https://www.who.int/news-room/detail/30-01-2020-statement-on-the-second-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-outbreak-of-novel-coronavirus-(2019-ncov, Available from URL, accessed March 2020; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan (2020) China. 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Available from URL, accessed March 2020; Abdullah, Z., Solamat, H., Singapore confirms first case of Wuhan virus. 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Available from URL, accessed March 2020; Chang, D., Xu, H., Rebaza, A., Sharma, L., Dela Cruz, C.S., Protecting health-care workers from subclinical coronavirus infection (2020) Lancet Respir Med; Li, J.P., Lam, D.S., Chen, Y., Ting, D.S., Novel coronavirus disease 2019 (COVID-19): the importance of recognising possible early ocular manifestation and using protective eyewear (2020) Br J Ophthalmol, 104, pp. 297-298; Recommended Guidance for Extended Use and Limited Reuse of N95 Filtering Facepiece Respirators in Healthcare Settings - NIOSH Workplace Safety and Health Topic, , https://www.cdc.gov/niosh/topics/hcwcontrols/recommendedguidanceextuse.html, accessed March 2020); Radonovich, L.J., Jr., Cheng, J., Shenal, B.V., Hodgson, M., Bender, B.S., Respirator tolerance in health care workers (2009) JAMA, 301, pp. 36-38; Rebmann, T., Carrico, R., Wang, J., Physiologic and other effects and compliance with long-term respirator use among medical intensive care unit nurses (2013) Am J Infect Control, 41, pp. 1218-1223; Fisher, E.M., Shaffer, R.E., Considerations for recommending extended use and limited reuse of filtering facepiece respirators in health care settings (2014) J Occup Environ Hyg, 11, pp. D115-D128; Rebmann, T., Alexander, S., Bartley, J., (2009) APIC position paper: extending the use and/or reusing respiratory protection in healthcare settings during disasters, , APIC, Washington, DC; Phan, L.T., Maita, D., Mortiz, D.C., Personal protective equipment doffing practices of healthcare workers (2019) J Occup Environ Hyg, 16, pp. 575-581; John, A., Tomas, M.E., Cadnum, J.L., Are health care personnel trained in correct use of personal protective equipment? (2016) Am J Infect Control, 44, pp. 840-842; (2015) Institute of Medicine, , National Academies Press (US), Defining PAPRs and Current Standards. DC; Roberge, R.J., Evaluation of the rationale for concurrent use of N95 filtering facepiece respirators with loose-fitting powered air-purifying respirators during aerosol-generating medical procedures (2008) Am J Infect Control, 36, pp. 135-141; Coates, M.J., Jundi, A.S., James, M.R., Chemical protective clothing; a study into the ability of staff to perform lifesaving procedures (2000) J Accid Emerg Med, 17, pp. 115-118; Laird, I.S., Goldsmith, R., Pack, R.J., Vitalis, A., The effect on heart rate and facial skin temperature of wearing respiratory protection at work (2002) Ann Occup Hyg, 46, pp. 143-148; Nicolle, L., SARS safety and science/La science et les mesures de sécurité contre le SRAS (2003) Can J Anesth; Kampf, G., Todt, D., Pfaender, S., Steinmann, E., Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents (2020) J Hosp Infect; Song, X., Vossebein, L., Zille, A., Efficacy of disinfectant-impregnated wipes used for surface disinfection in hospitals: a review (2019) Antimicrob Resist Infect Control; Pottage, T., Richardson, C., Parks, S., Walker, J.T., Bennett, A.M., Evaluation of hydrogen peroxide gaseous disinfection systems to decontaminate viruses (2010) J Hosp Infect, 74, pp. 55-61; Goyal, S.M., Chander, Y., Yezli, S., Otter, J.A., Evaluating the virucidal efficacy of hydrogen peroxide vapour (2014) J Hosp Infect, 86, pp. 255-259; Kim, D.K., Kang, D.H., UVC LED irradiation effectively inactivates aerosolized viruses, bacteria, and fungi in a chamber-type air disinfection system (2018) Appl Environ Microbiol","Wong, J.; Division of Anaesthesiology, Singapore General Hospital, Outram Road, Singapore; email: jolin.wong@singhealth.com.sg",,Springer,0832610X,,CJOAE,32162212,English,Can. J. Anesth.,Review,Article in Press,Open Access,Scopus,2-s2.0-85081896575,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Arvind B., Medigeshi G.R., Kapil A., Xess I., Singh U., Lodha R., Kabra S.K.",57213194074;8727401000;7006642821;6603068267;57202487683;7007019609;36488033400;,Aetiological agents for pulmonary exacerbations in children with cystic fibrosis: An observational study from a tertiary care centre in northern India,2020,The Indian journal of medical research,151,1,,65,70,,,10.4103/ijmr.IJMR_1275_18,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081041239&doi=10.4103%2fijmr.IJMR_1275_18&partnerID=40&md5=e87312da69bb0f65fe9ef66ec064c4c9,"Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India; Translational Health Science & Technology Institute, Faridabad, Haryana, India; Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India","Arvind, B., Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India; Medigeshi, G.R., Translational Health Science & Technology Institute, Faridabad, Haryana, India; Kapil, A., Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India; Xess, I., Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India; Singh, U., Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India; Lodha, R., Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India; Kabra, S.K., Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India","Background & objectives: Pulmonary disease is the main cause of morbidity and mortality in cystic fibrosis (CF). The infection occurs with a unique spectrum of bacterial pathogens that are usually acquired in an age-dependent fashion. The objective of this study was to find out the aetiological agents in respiratory specimens from children with CF during pulmonary exacerbation and relate with demographic variables. Methods: In this observational study, airway secretions from children (n=104) with CF presenting with pulmonary exacerbations were collected and tested for bacteria, fungi, mycobacteria and viral pathogens using appropriate laboratory techniques. The frequencies of isolation of various organisms were calculated and associated with various demographic profiles. Results: Bacteria were isolated in 37 (35.5%) and viral RNA in 27 (29.3%) children. Pseudomonas was the most common bacteria grown in 31 (29.8%) followed by Burkholderia cepacia complex (Bcc) in three (2.8%) patients. Among viruses, Rhinovirus was the most common, identified in 16 (17.4%) samples followed by coronavirus in four (4.3%). Fungi and mycobacteria were isolated from 23 (22.1%) and four (3.8%) children, respectively. Aspergillus flavus was the most common fungus isolated in 13 (12.5%) children. Interpretation & conclusions: Pseudomonas was the most common organism isolated during exacerbation. Non-tuberculous mycobacteria were not isolated, whereas infection with Bcc and Mycobacterium tuberculosis was observed, which could probably have a role in CF morbidity. Polymicrobial infections were associated with severe exacerbations.",Acute exacerbation; children; cystic fibrosis; microbiology; polymicrobial infection; Pseudomonas,,,,,NLM (Medline),9715916,,,32134016,English,Indian J. Med. Res.,Article,Final,Open Access,Scopus,2-s2.0-85081041239,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Satheesan M.K., Mui K.W., Wong L.T.",57214993651;8650785900;55800840000;,A numerical study of ventilation strategies for infection risk mitigation in general inpatient wards,2020,Building Simulation,,,,,,,,10.1007/s12273-020-0623-4,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079671556&doi=10.1007%2fs12273-020-0623-4&partnerID=40&md5=26f3f064d1d3bf6cfbee40dcea0717b1,"Department of Building Services Engineering, The Hong Kong Polytechnic University, Hong Kong","Satheesan, M.K., Department of Building Services Engineering, The Hong Kong Polytechnic University, Hong Kong; Mui, K.W., Department of Building Services Engineering, The Hong Kong Polytechnic University, Hong Kong; Wong, L.T., Department of Building Services Engineering, The Hong Kong Polytechnic University, Hong Kong","Aerial dispersion of human exhaled microbial contaminants and subsequent contamination of surfaces is a potential route for infection transmission in hospitals. Most general hospital wards have ventilation systems that drive air and thus contaminants from the patient areas towards the corridors. This study investigates the transport mechanism and deposition patterns of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) within a typical six bedded general inpatient ward cubicle through numerical simulation. It demonstrates that both air change and exhaust airflow rates have significant effects on not only the airflow but also the particle distribution within a mechanically ventilated space. Moreover, the location of an infected patient within the ward cubicle is crucial in determining the extent of infection risk to other ward occupants. Hence, it is recommended to provide exhaust grilles in close proximity to a patient, preferably above each patient’s bed. To achieve infection prevention and control, high exhaust airflow rate is also suggested. Regardless of the ventilation design, all patients and any surfaces within a ward cubicle should be regularly and thoroughly cleaned and disinfected to remove microbial contamination. The outcome of this study can serve as a source of reference for hospital management to better ventilation design strategies for mitigating the risk of infection. © 2020, Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature.",bioaerosol dispersion; computational fluid dynamics (CFD); hospital general ward; indoor air quality (IAQ); infection risk; ventilation,Air quality; Antennas; Computational fluid dynamics; Contamination; Dispersions; Hospitals; Indoor air pollution; Ventilation; Bioaerosol dispersion; Indoor air quality; Infection transmission; Microbial contaminant; Microbial contamination; Particle distributions; Prevention and controls; Ventilation strategy; Air,"(2010) Ansys Fluent 13.0 Documentation, , Ansys Inc., Lebanon, NH, USA; (2013) ASHRAE Standard. Ventilation for Health Care Facilities, , American Society of Heating, Refrigerating and Air-Conditioning Engineers, Atlanta, GA, USA; (2013) ASHRAE Fundamentals SI Handbook, , American Society of Heating, Refrigerating and Air-Conditioning Engineers, Atlanta, GA, USA; Beggs, C.B., Kerr, K.G., Noakes, C.J., Hathway, E.A., Sleigh, P.A., The ventilation of multiple-bed hospital wards: Review and analysis (2008) American Journal of Infection Control, 36, pp. 250-259; Blocken, B., LES over RANS in building simulation for outdoor and indoor applications: a foregone conclusion? (2018) Building Simulation, 11, pp. 821-870; Bolashikov, Z., Melikov, A., Kierat, W., Popiołek, Z., Brand, M., Exposure of health care workers and occupants to coughed airborne pathogens in a double-bed hospital patient room with overhead mixing ventilation (2012) HVAC & R Research, 18, pp. 602-615; Chao, C.Y.H., Wan, M.P., Sze To, G.N., Transport and removal of expiratory droplets in hospital ward environment (2008) Aerosol Science and Technology, 42, pp. 377-394; Chaudhury, H., Mahmood, A., Valente, M., Advantages and disadvantages of single-versus multiple-occupancy rooms in acute care environments: A review and analysis of the literature (2005) Environment and Behavior, 37, pp. 760-786; Chen, Q., Comparison of different k-ε models for indoor air flow computations (1995) Numerical Heat Transfer, Part B: Fundamentals, 28, pp. 353-369; Chen, C., Zhao, B., Yang, X., Li, Y., Role of two-way airflow owing to temperature difference in severe acute respiratory syndrome transmission: Revisiting the largest nosocomial severe acute respiratory syndrome outbreak in Hong Kong (2011) Journal of the Royal Society Interface, 8, pp. 699-710; Duguid, J.P., The size and the duration of air-carriage of respiratory droplets and droplet-nuclei (1946) Journal of Hygiene, 44, pp. 471-479; Gao, N.P., Niu, J.L., CFD study of the thermal environment around a human body: A review (2005) Indoor and Built Environment, 14, pp. 5-16; Ghia, U., Konangi, S., Kishore, A., Gressel, M., Mead, K., Earnest, G., Assessment of health-care worker exposure to pandemic flu in hospital rooms (2012) ASHRAE Transactions, 118 (1), pp. 442-449; Giannini, M.A., Nance, D., McCullers, J.A., Are toilet seats a vector for transmission of methicillin-resistant Staphylococcus aureus? (2009) American Journal of Infection Control, 37, pp. 505-506; Gralton, J., Tovey, E., McLaws, M.L., Rawlinson, W.D., The role of particle size in aerosolised pathogen transmission: A review (2011) Journal of Infection, 62, pp. 1-13; Hang, J., Li, Y., Jin, R., The influence of human walking on the flow and airborne transmission in a six-bed isolation room: Tracer gas simulation (2014) Building and Environment, 77, pp. 119-134; Humphreys, H., Overcrowding, understaffing and infection in hospitals (2006) Irish Medical Journal, 99, p. 102. , [PubMed]; Kim, S.H., Chang, S.Y., Sung, M., Park, J.H., Bin Kim, H., Lee, H., Choi, J.P., Min, J.Y., Extensive viable middle east respiratory syndrome (MERS) coronavirus contamination in air and surrounding environment in MERS isolation wards (2016) Clinical Infectious Diseases, 63, pp. 363-369; Lai, A.C.K., Wong, L.T., Mui, K.W., Chan, W.Y., Yu, H.C., An experimental study of bioaerosol (1–10 (µm) deposition in a ventilated chamber (2012) Building and Environment, 56, pp. 118-126; Li, Y., Huang, X., Yu, I.T.S., Wong, T.W., Qian, H., Role of air distribution in SARS transmission during the largest nosocomial outbreak in Hong Kong (2005) Indoor Air, 15, pp. 83-95; Li, Y., Leung, G.M., Tang, J.W., Yang, X., Chao, C.Y.H., Lin, J.Z., Lu, J.W., Yuen, P.L., Role of ventilation in airborne transmission of infectious agents in the built environment—A multidisciplinary systematic review (2007) Indoor Air, 17, pp. 2-18; Li, Y., Tang, J., Noakes, C., Hodgson, M.J., Engineering control of respiratory infection and low-energy design of healthcare facilities (2015) Science and Technology for the Built Environment, 21, pp. 25-34; Licina, D., Melikov, A., Pantelic, J., Sekhar, C., Tham, K.W., Human convection flow in spaces with and without ventilation: Personal exposure to floor-released particles and cough-released droplets (2015) Indoor Air, 25, pp. 672-682; Memarzadeh, F., Xu, W., Role of air changes per hour (ACH) in possible transmission of airborne infections (2012) Building Simulation, 5, pp. 15-28; Nicas, M., Hubbard, A.E., Jones, R.M., Reingold, A.L., The infectious dose of variola (smallpox) virus (2004) Applied Biosafety, 9, pp. 118-127; Nielsen, P.V., Fifty years of CFD for room air distribution (2015) Building and Environment, 91, pp. 78-90; Oh, M.D., Park, W.B., Park, S.W., Choe, P.G., Bang, J.H., Song, K.H., Kim, E.S., Kim, N.J., Middle East respiratory syndrome: What we learned from the 2015 outbreak in the Republic of Korea (2018) Korean Journal of Internal Medicine, 33, pp. 233-246; Pantelic, J., Tham, K.W., Adequacy of air change rate as the sole indicator of an air distribution system’s effectiveness to mitigate airborne infectious disease transmission caused by a cough release in the room with overhead mixing ventilation: A case study (2013) HVAC&R Research, 19, pp. 947-961; Qian, H., Li, Y., Removal of exhaled particles by ventilation and deposition in a multibed airborne infection isolation room (2010) Indoor Air, 20, pp. 284-297; Roache, P.J., Verification of codes and calculations (1998) AIAA Journal, 36, pp. 696-702; Roy, C.J., Milton, D.K., Airborne transmission of communicable infection—the elusive pathway (2004) New England Journal of Medicine, 350, pp. 1710-1712; Shen, C., Gao, N., Wang, T., CFD study on the transmission of indoor pollutants under personalized ventilation (2013) Building and Environment, 63, pp. 69-78; Tang, J.W., Wilson, P., Shetty, N., Noakes, C.J., Aerosol-transmitted infections—A new consideration for public health and infection control teams (2015) Current Treatment Options in Infectious Diseases, 7, pp. 176-201; Tian, L., Lin, Z., Wang, Q., Liu, J., Numerical investigation of indoor aerosol particle dispersion under stratum ventilation and under displacement ventilation (2009) Indoor and Built Environment, 18, pp. 360-375; Van Doremalen, N., Bushmaker, T., Munster, V.J.E., Stability of Middle East respiratory syndrome Coronavirus (MERS-CoV) under different environmental conditions (2013) Euro Surveillance, 18, p. 20590; Wan, M.P., Chao, C.Y.H., Ng, Y.D., Sze To, G.N., Yu, W.C., Dispersion of expiratory droplets in a general hospital ward with ceiling mixing type mechanical ventilation system (2007) Aerosol Science and Technology, 41, pp. 244-258; Wells, W.F., (1955) Airborne Contagion and Air Hygiene. An Ecological Study of Droplet Infections, , Harvard University Press, Cambridge, USA; Wong, L.T., Chan, W.Y., Mui, K.W., Lai, A.C.K., An experimental and numerical study on deposition of bioaerosols in a scaled chamber (2010) Aerosol Science and Technology, 44, pp. 117-128; Wong, L.T., Yu, H.C., Mui, K.W., Chan, W.Y., Drag constants for common indoor bioaerosols (2015) Indoor and Built Environment, 24, pp. 401-413; Xiao, S., Li, Y., Sung, M., Wei, J., Yang, Z., A study of the probable transmission routes of MERS-CoV during the first hospital outbreak in the Republic of Korea (2018) Indoor Air, 28, pp. 51-63; Xie, X., Li, Y., Chwang, A.T.Y., Ho, P.L., Seto, W.H., How far droplets can move in indoor environments—revisiting the Wells evaporation-falling curve (2007) Indoor Air, 17, pp. 211-225; Yu, H.C., Mui, K.W., Wong, L.T., Chu, H.S., Ventilation of general hospital wards for mitigating infection risks of three kinds of viruses including Middle East respiratory syndrome coronavirus (2017) Indoor and Built Environment, 26, pp. 514-527; Zeytounian, R.K., Joseph Boussinesq and his approximation: A contemporary view (2003) Comptes Rendus Mécanique, 331, pp. 575-586; Zhang, Z., Chen, Q., Experimental measurements and numerical simulations of particle transport and distribution in ventilated rooms (2006) Atmospheric Environment, 40, pp. 3396-3408; Zhang, Z., Chen, Q., Comparison of the Eulerian and Lagrangian methods for predicting particle transport in enclosed spaces (2007) Atmospheric Environment, 41, pp. 5236-5248; Zhang, Z., Zhang, W., Zhai, Z.J., Chen, Q.Y., Evaluation of various turbulence models in predicting airflow and turbulence in enclosed environments by CFD: part 2—comparison with experimental data from literature (2007) HVAC&R Research, 13, pp. 871-886; Zhao, B., Zhang, Y., Li, X., Yang, X., Huang, D., Comparison of indoor aerosol particle concentration and deposition in different ventilated rooms by numerical method (2004) Building and Environment, 39, pp. 1-8; Zumla, A., Hui, D.S., Perlman, S., Middle East respiratory syndrome (2015) The Lancet, 386, pp. 995-1007","Wong, L.T.; Department of Building Services Engineering, The Hong Kong Polytechnic UniversityHong Kong; email: beltw@polyu.edu.hk",,Tsinghua University Press,19963599,,,,English,Build. Simul.,Article,Article in Press,Open Access,Scopus,2-s2.0-85079671556,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Ren G., Liu F., Huang M., Li L., Shang H., Liang M., Luo Q., Chen R.",57195492227;57204496335;57195490506;57215051333;57213836869;57213821414;57215155119;53981013500;,Pathogenicity of a QX-like avian infectious bronchitis virus isolated in China,2020,Poultry Science,99,1,,111,118,,,10.3382/ps/pez568,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077974106&doi=10.3382%2fps%2fpez568&partnerID=40&md5=df5782fb0fe957eab56039db754a4eee,"Key Laboratory of Biotechnology and Drug Manufacture for Animal Epidemic Prevention, Ministry of Agriculture, Zhaoqing, 526238, China; Zhaoqing Institute of Biotechnology Co., Ltd, Zhaoqing, 526238, China; College of Veterinary Medicine, South China Agriculture University, Guangzhou, 510642, China","Ren, G., Key Laboratory of Biotechnology and Drug Manufacture for Animal Epidemic Prevention, Ministry of Agriculture, Zhaoqing, 526238, China, Zhaoqing Institute of Biotechnology Co., Ltd, Zhaoqing, 526238, China; Liu, F., College of Veterinary Medicine, South China Agriculture University, Guangzhou, 510642, China; Huang, M., Key Laboratory of Biotechnology and Drug Manufacture for Animal Epidemic Prevention, Ministry of Agriculture, Zhaoqing, 526238, China, Zhaoqing Institute of Biotechnology Co., Ltd, Zhaoqing, 526238, China; Li, L., Key Laboratory of Biotechnology and Drug Manufacture for Animal Epidemic Prevention, Ministry of Agriculture, Zhaoqing, 526238, China; Shang, H., Key Laboratory of Biotechnology and Drug Manufacture for Animal Epidemic Prevention, Ministry of Agriculture, Zhaoqing, 526238, China; Liang, M., Key Laboratory of Biotechnology and Drug Manufacture for Animal Epidemic Prevention, Ministry of Agriculture, Zhaoqing, 526238, China; Luo, Q., Key Laboratory of Biotechnology and Drug Manufacture for Animal Epidemic Prevention, Ministry of Agriculture, Zhaoqing, 526238, China, Zhaoqing Institute of Biotechnology Co., Ltd, Zhaoqing, 526238, China; Chen, R., Key Laboratory of Biotechnology and Drug Manufacture for Animal Epidemic Prevention, Ministry of Agriculture, Zhaoqing, 526238, China, Zhaoqing Institute of Biotechnology Co., Ltd, Zhaoqing, 526238, China, College of Veterinary Medicine, South China Agriculture University, Guangzhou, 510642, China","Avian infectious bronchitis is a serious and highly contagious disease caused by infectious bronchitis virus (IBV). We isolated a highly virulent IBV strain (CK/CH/JS/TAHY) from kidneys of diseased chickens. Phylogenetic analysis based on the S1 gene revealed that CK/CH/JS/TAHY clustered with the QX-like type. The S1 gene has 1,620 nucleotides and encoded a polypeptide of 540 amino acids with typical coronavirus cleavage recognition sites of HRRR. About 1-day-old specific pathogen-free White Leghorn chickens inoculated with CK/CH/JS/TAHY at 105.5 EID50 exhibited clinical signs including coughing, sneezing, nasal discharge, and tracheal vocalization accompanied by depression with 84% mortality and 100% morbidity. The kidneys of dead birds were swollen and pale and exhibited severe urate deposition. Histopathological examination revealed kidney hemorrhages, multifocal necrosis of the renal tubules and trachea with cilia loss, sloughing of epithelial cells, and edema of the lamina propria. IBV-specific antibodies appeared at 10 D post-infection. Chickens vaccinated with a CK/CH/JS/TAHY oil-emulsion vaccine showed 26.7% morbidity and 3% mortality indicating a protective effect. In conclusion, the IBV strain is a virulent avian IBV and that exhibited severe pathogenicity in chickens and is a vaccine candidate to prevent infection by Chinese QX-like nephropathogenic IBV strains. © 2019 The Author(s)",avian infectious bronchitis; pathogenicity; QX-like type,,"Bande, F., Arshad, S.S., Omar, A.R., Hair-Bejo, M., Mahmuda, A., Nair, V., Global distributions and strain diversity of avian infectious bronchitis virus: a review (2017) Anim. Health. Res. Rev., 18, pp. 70-83; Boursnell, M.E., Brown, T.D., Foulds, I.J., Green, P.F., Tomley, F.M., Binns, M.M., The complete nucleotide sequence of avian infectious bronchitis virus: analysis of the polymerase-coding region (1987) Adv. Exp. Med. 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Dis., 18, pp. 1994-2001; Feng, K., Xue, Y., Wang, J., Chen, W., Chen, F., Bi, Y., Xie, Q., Development and efficacy of a novel live-attenuated QX-like nephropathogenic infectious bronchitis virus vaccine in China (2015) Vaccine, 33, pp. 1113-1120; Han, Z., Sun, C., Yan, B., Zhang, X., Wang, Y., Li, C., Zhang, Q., Liu, S., A 15-year analysis of molecular epidemiology of avian infectious bronchitis coronavirus in China (2011) Infect. Genet. 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Vet. Res., 81; Koch, G., Hartog, L., Kant, A., van Roozelaar, D.J., Antigenic domains on the peplomer protein of avian infectious bronchitis virus: correlation with biological functions (1990) J. Gen. Virol., 71, pp. 1929-1935; Ladman, B.S., Loupos, A.B., Gelb, J., Jr, Infectious bronchitis virus S1 gene sequence comparison is a better predictor of challenge of immunity in chickens than serotyping by virus neutralization (2006) Avian Pathol., 35, pp. 127-133; Li, M., Mo, M.L., Huang, B.C., Fan, W.S., Wei, Z.J., Wei, T.C., Li, K.R., Wei, P., Continuous evolution of avian infectious bronchitis virus resulting in different variants co-circulating in Southern China (2013) Arch. Virol., 158, pp. 1783-1786; Liu, S., Kong, X., A new genotype of nephropathogenic infectious bronchitis virus circulating in vaccinated and non-vaccinated flocks in China (2004) Avian Pathol., 33, pp. 321-327; Liu, S., Zhang, X., Wang, Y., Li, C., Han, Z., Shao, Y., Li, H., Kong, X., Molecular characterization and pathogenicity of infectious bronchitis coronaviruses: complicated evolution and epidemiology in china caused by cocirculation of multiple types of infectious bronchitis coronaviruses (2009) Intervirology., 52, pp. 223-234; Liu, X.L., Su, J.L., Zhao, J.X., Zhang, G.Z., Complete genome sequence analysis of a predominant infectious bronchitis virus (IBV) strain in China (2009) Virus Genes., 38, pp. 56-65; Liu, S.W., Zhang, Q.X., Chen, J.D., Han, Z.X., Liu, X., Feng, L., Shao, Y.H., Tong, G.Z., Genetic diversity of avian infectious bronchitis coronavirus strains isolated in China between 1995 and 2004 (2006) Arch. Virol., 151, pp. 1133-1148; Meeusen, E.N., Walker, J., Peters, A., Pastoret, P.P., Jungersen, G., Current status of veterinary vaccines (2007) Clin. Microbiol. Rev., 20, pp. 489-510. , table of contents; Shi, X.M., Zhao, Y., Gao, H.B., Jing, Z., Wang, M., Cui, H.Y., Tong, G.Z., Wang, Y.F., Evaluation of recombinant fowlpox virus expressing infectious bronchitis virus S1 gene and chicken interferon-gamma gene for immune protection against heterologous strains (2011) Vaccine., 29, pp. 1576-1582; Shokri, S., Karimi, V., Langeroudi, A.G., Marandi, M.V., Hashamzadeh, M., Zabihipetroudi, T., Najafi, H., Tehrani, F., Seroprevalence and genotyping of avian infectious bronchitis virus detected from Iranian unvaccinated backyard chickens (2018) Iran. J. 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Virol., 44, pp. 794-803; Sun, C., Han, Z., Ma, H., Zhang, Q., Yan, B., Shao, Y., Xu, J., Liu, S., Phylogenetic analysis of infectious bronchitis coronaviruses newly isolated in China, and pathogenicity and evaluation of protection induced by Massachusetts serotype H120 vaccine against QX-like strains (2011) Avian Pathol., 40, pp. 43-54; Worthington, K.J., Currie, R.J., Jones, R.C., A reverse transcriptase-polymerase chain reaction survey of infectious bronchitis virus genotypes in Western Europe from 2002 to 2006 (2008) Avian Pathol., 37, pp. 247-257; Xia, J., He, X., Du, L.J., Liu, Y.Y., You, G.J., Li, S.Y., Liu, P., Huang, Y., Preparation and protective efficacy of a chicken embryo kidney cell-attenuation GI-19/QX-like avian infectious bronchitis virus vaccine (2018) Vaccine., 36, pp. 4087-4094; Yan, S., Zhao, J., Xie, D., Huang, X., Cheng, J., Guo, Y., Liu, C., Zhang, G., Attenuation, safety, and efficacy of a QX-like infectious bronchitis virus serotype vaccine (2018) Vaccine., 36, pp. 1880-1886; Zhao, W., Gao, M., Xu, Q., Xu, Y., Zhao, Y., Chen, Y., Zhang, T., Liu, S., Origin and evolution of LX4 genotype infectious bronchitis coronavirus in China (2017) Vet. Microbiol., 198, pp. 9-16; Zhao, Y., Cheng, J.L., Liu, X.Y., Zhao, J., Hu, Y.X., Zhang, G.Z., Safety and efficacy of an attenuated Chinese QX-like infectious bronchitis virus strain as a candidate vaccine (2015) Vet. Microbiol., 180, pp. 49-58; Zou, N.L., Zhao, F.F., Wang, Y.P., Liu, P., Cao, S.J., Wen, X.T., Huang, Y., Genetic analysis revealed LX4 genotype strains of avian infectious bronchitis virus became predominant in recent years in Sichuan area, China (2010) Virus Genes., 41, pp. 202-209","Chen, R.; Key Laboratory of Biotechnology and Drug Manufacture for Animal Epidemic Prevention, Ministry of AgricultureChina; email: chensa727@126.com",,Elsevier Inc.,325791,,,,English,Poult. Sci.,Article,Final,Open Access,Scopus,2-s2.0-85077974106,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Qian S., Jia X., Gao Z., Zhang W., Xu Q., Li Z.",57190955728;57211376609;57213588787;57211378145;57213603133;35305208200;,Isolation and identification of porcine deltacoronavirus and alteration of immunoglobulin transport receptors in the intestinal mucosa of PdCoV-infected piglets,2020,Viruses,12,1,79,,,,,10.3390/v12010079,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077897887&doi=10.3390%2fv12010079&partnerID=40&md5=5207795a9f9ec0e6e11e8834a70ea713,"State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Wuhan, 430070, China; Key Laboratory of Development of Veterinary Diagnostic Products, Ministry of Agriculture of the People’s Republic of China, Wuhan, 430070, China","Qian, S., State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; Jia, X., State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; Gao, Z., State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; Zhang, W., State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; Xu, Q., State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Wuhan, 430070, China, Key Laboratory of Development of Veterinary Diagnostic Products, Ministry of Agriculture of the People’s Republic of China, Wuhan, 430070, China; Li, Z., State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Wuhan, 430070, China, Key Laboratory of Development of Veterinary Diagnostic Products, Ministry of Agriculture of the People’s Republic of China, Wuhan, 430070, China","Porcine deltacoronavirus (PDCoV) is a porcine enteropathogenic coronavirus that causes watery diarrhea, vomiting, and frequently death in piglets, causing serious economic losses to the pig industry. The strain CHN-JS-2017 was isolated and identified by cytopathology, immunofluorescence assays, transmission electron microscopy, and sequence analysis. A nucleotide sequence alignment showed that the whole genome of CHN-JS-2017 is 97.4%–99.6% identical to other PDCoV strains. The pathogenicity of the CHN-JS-2017 strain was investigated in orally inoculated five-day-old piglets; the piglets developed acute, watery diarrhea, but all recovered and survived. CHN-JS-2017 infection-induced microscopic lesions were observed, and viral antigens were detected mainly by immunohistochemical staining in the small intestine. The neonatal Fc receptor (FcRn) and polymeric immunoglobulin receptor (pIgR) are crucial immunoglobulin (Ig) receptors for the transcytosis ofimmunoglobulin G (IgG), IgA, or IgM. Importantly, CHN-JS-2017 infected five-day-old piglets could significantly down-regulate the expression of FcRn, pIgR, and nuclear factor-kappa B (NF-κB)in the intestinal mucosa. Note that the level of FcRn mRNA in the intestinal mucosa of normal piglets is positively correlated with pIgR and NF-κB. At the same time, the expressions of FcRn, pIgR, and NF-κB mRNA are also positively correlated in infected piglets. These results may help explain the immunological and pathological changes associated with porcine deltacorononirus infection. © 2020 by the authors.",Neonatal Fc receptor; NF-κB; Polymeric immunoglobulin receptor; Porcine deltacoronavirus,"Fc receptor; immunoglobulin A; immunoglobulin enhancer binding protein; immunoglobulin G; immunoglobulin M; immunoglobulin receptor; secretory component; Fc receptor; Fc receptor, neonatal; HLA antigen class 1; immunoglobulin enhancer binding protein; secretory component; virus antigen; virus RNA; 3' untranslated region; animal cell; animal experiment; animal model; animal tissue; anorexia; Article; controlled study; Coronavirinae; Deltacoronavirus; down regulation; fluorescence microscopy; gene deletion; gene expression; histopathology; ID50 (median infectious dose); immune response; immunofluorescence; immunohistochemistry; intestine mucosa; lethargy; mRNA expression level; nonhuman; phylogenetic tree; piglet; porcine epidemic diarrhea; protein expression; real time polymerase chain reaction; reverse transcription polymerase chain reaction; sequence analysis; transcytosis; transmission electron microscopy; virus identification; virus isolation; virus virulence; vomiting; Western blotting; animal; classification; Coronavirinae; Coronavirus infection; diarrhea; DNA sequence; gene expression regulation; immunology; intestine mucosa; isolation and purification; phylogeny; pig; sequence alignment; small intestine; swine disease; veterinary medicine; virology; virus shedding; Animals; Antigens, Viral; Coronavirus; Coronavirus Infections; Diarrhea; Gene Expression Regulation; Histocompatibility Antigens Class I; Intestinal Mucosa; Intestine, Small; NF-kappa B; Phylogeny; Receptors, Fc; Receptors, Polymeric Immunoglobulin; RNA, Viral; Sequence Alignment; Sequence Analysis, DNA; Swine; Swine Diseases; Virus Shedding","Woo, P.C., Lau, S.K., Lam, C.S., Lau, C.C., Tsang, A.K., Lau, J.H., Bai, R., Wang, M., Discovery of seven novel Mammalian and avian coronaviruses in the genus deltacoronavirus supports bat coronaviruses as the gene source of alphacoronavirus and betacoronavirus and avian coronaviruses as the gene source of gammacoronavirus and deltacoronavirus (2012) J. 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Dis., 21, pp. 650-654; Hu, H., Jung, K., Vlasova, A.N., Saif, L.J., Experimental infection of gnotobiotic pigs with the cell-culture-adapted porcine deltacoronavirus strain OH-FD22 (2016) Arch. Virol., 161, pp. 3421-3434; Chen, Q., Gauger, P., Stafne, M., Thomas, J., Arruda, P., Burrough, E., Madson, D., Derscheid, R., Pathogenicity and pathogenesis of a United States porcine deltacoronavirus cell culture isolate in 5-day-old neonatal piglets (2015) Virology, 482, pp. 51-59; Dong, N., Fang, L., Yang, H., Liu, H., Du, T., Fang, P., Wang, D., Xiao, S., Isolation, genomic characterization, and pathogenicity of a Chinese porcine deltacoronavirus strain CHN-HN-2014 (2016) Vet. Microbiol., 196, pp. 98-106; Vitosh-Sillman, S., Loy, J.D., Brodersen, B., Kelling, C., Doster, A., Topliff, C., Nelson, E., Poulsen, E., Experimental infection of conventional nursing pigs and their dams with Porcine deltacoronavirus (2016) J. Vet. Diagn. Investig. Off. Publ. Am. Assoc. Vet. Lab. Diagn. 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USA, 108, pp. 4388-4393; Luo, J., Fang, L., Dong, N., Fang, P., Ding, Z., Wang, D., Chen, H., Xiao, S., Porcine deltacoronavirus (PDCoV) infection suppresses RIG-I-mediated interferon-beta production (2016) Virology, 495, pp. 10-17; Fang, P., Fang, L., Ren, J., Hong, Y., Liu, X., Zhao, Y., Wang, D., Xiao, S., Porcine deltacoronavirus accessory protein NS6 antagonizes interferon beta production by interfering with the binding of RIG-I/MDA5 to double-stranded RNA (2018) J. Virol., 92, pp. e00712-e00718; Chen, J., Fang, P., Wang, M., Peng, Q., Ren, J., Wang, D., Peng, G., Ding, Z., Porcine deltacoronavirus nucleocapsid protein antagonizes IFN-beta production by impairing dsRNA and PACT binding to RIG-I (2019) Virus Genes, 55, pp. 520-531; Likai, J., Shasha, L., Wenxian, Z., Jingjiao, M., Jianhe, S., Hengan, W., Yaxian, Y., Porcine Deltacoronavirus Nucleocapsid Protein Suppressed IFN-beta Production by Interfering Porcine RIG-I dsRNA-Binding and K63-Linked Polyubiquitination (2019) Front. 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Dis., 62, pp. 575-580; Chen, F., Zhu, Y., Wu, M., Ku, X., Yao, L., He, Q., Full-length genome characterization of Chinese porcine deltacoronavirus strain CH/SXD1/2015 (2015) Genome Announc, 3, p. e01284; Liu, B.J., Zuo, Y.Z., Gu, W.Y., Luo, S.X., Shi, Q.K., Hou, L.S., Zhong, F., Fan, J.H., Isolation and phylogenetic analysis of porcine deltacoronavirus from pigs with diarrhoea in Hebei province, China (2018) Transbound. Emerg. Dis., 65, pp. 874-882; Madson, D.M., Magstadt, D.R., Arruda, P.H., Hoang, H., Sun, D., Bower, L.P., Bhandari, M., Pillatzki, A.E., Pathogenesis of porcine epidemic diarrhea virus isolate (US/Iowa/18984/2013) in 3-week-old weaned pigs (2014) Vet. Microbiol., 174, pp. 60-68; Turula, H., Wobus, C.E., The role of the polymeric immunoglobulin receptor and secretory immunoglobulins during mucosal infection and immunity (2018) Viruses, 10, p. 237; Liu, X., Palaniyandi, S., Zhu, I., Tang, J., Li, W., Wu, X., Ochsner, S.P., Zhu, X., Human cytomegalovirus evades antibody-mediated immunity through endoplasmic reticulum-associated degradation of the FcRn receptor (2019) Nat. Commun., 10, p. 3020; Johansen, F.E., Brandtzaeg, P., Transcriptional regulation of the mucosal IgA system (2004) Trends Immunol, 25, pp. 150-157; Pal, K., Kaetzel, C.S., Brundage, K., Cunningham, C.A., Cuff, C.F., Regulation of polymeric immunoglobulin receptor expression by reovirus (2005) J. Gen. Virol., 86, pp. 2347-2357; Liu, X., Ye, L., Christianson, G.J., Yang, J.Q., Roopenian, D.C., Zhu, X., NF-kappaB signaling regulates functional expression of the MHC class I-related neonatal Fc receptor for IgG via intronic binding sequences (2007) J. Immunol., 179, pp. 2999-3011; Liu, X., Ye, L., Bai, Y., Mojidi, H., Simister, N.E., Zhu, X., Activation of the JAK/STAT-1 signaling pathway by IFN-gamma can down-regulate functional expression of the MHC class I-related neonatal Fc receptor for IgG (2008) J. Immunol., 181, pp. 449-463. , Baltimore, Md. 1950 CrossRef PubMed; Wang, Y., Yang, G.B., Alteration of polymeric immunoglobulin receptor and neonatal Fc receptor expression in the gut mucosa of immunodeficiency virus-infected rhesus macaques (2016) Scand. J. Immunol., 83, pp. 235-243; Li, D., Wang, F.J., Yu, L., Yao, W.R., Cui, Y.F., Yang, G.B., Expression of pIgR in the tracheal mucosa of SHIV/SIV-infected rhesus macaques (2017) Zool. Res., 38, pp. 44-48","Li, Z.; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural UniversityChina; email: lizili@mail.hzau.edu.cn",,MDPI AG,19994915,,,31936476,English,Viruses,Article,Final,Open Access,Scopus,2-s2.0-85077897887,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Mohamed R.A.E.H., Aleanizy F.S., Alqahtani F.Y., Alanazi M.S., Mohamed N.",57205681637;55236547400;56282382200;34067501600;7103398147;,Common co-morbidities are challenging in the diagnosis of middle east respiratory syndrome (MERS-CoV) in Saudi Arabia,2020,Pakistan Journal of Biological Sciences,23,2,,119,125,,,10.3923/pjbs.2020.119.125,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077518368&doi=10.3923%2fpjbs.2020.119.125&partnerID=40&md5=3e044607563a7abc6a2c05942624cce1,"Department of Biology, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, 12484, Saudi Arabia; Federal Ministry of Health, Khartoum, 303, Sudan; Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 22452, Riyadh, 11495, Saudi Arabia; Department of Emergency, Prince Mohammed Bin Abdulaziz Hospital, Ministry of Health, Riyadh, 12455, Saudi Arabia; Researcher at University Hospital, Virology, Plan 2, Umea University, 85 Umea, SE-901, Sweden","Mohamed, R.A.E.H., Department of Biology, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, 12484, Saudi Arabia, Federal Ministry of Health, Khartoum, 303, Sudan; Aleanizy, F.S., Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 22452, Riyadh, 11495, Saudi Arabia; Alqahtani, F.Y., Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 22452, Riyadh, 11495, Saudi Arabia; Alanazi, M.S., Department of Emergency, Prince Mohammed Bin Abdulaziz Hospital, Ministry of Health, Riyadh, 12455, Saudi Arabia; Mohamed, N., Researcher at University Hospital, Virology, Plan 2, Umea University, 85 Umea, SE-901, Sweden","Background and Objective: Middle East respiratory syndrome coronavirus (MERS-CoV) is a relatively recent human disease reported initially in Saudi Arabia in September, 2012. Morbidities investigation includes a process of excluding other possible options until certain suspected cases are confirmed. Material and Methods: In this study, we formulated a model under the authorization of the Saudi Ministry of Health to accurately identify cases among admitted suspected cases depending on specific signs and symptoms. Real-time polymerase chain reaction was used for confirmation of the positive cases. Results: The results showed that the number of patients with combined symptoms of fever/sore throat and fever/cough/SOB was significantly higher in confirmed cases than in non-confirmed cases (p<0.05). Besides, the number of confirmed MERS-CoV cases was significantly higher among cases included in the study than excluded cases. It was also clearly demonstrated that fever combined with other symptoms represents 60% of the confirmed cases, which is significantly higher than for cases with other combined symptoms (p<0.0001). Conclusion: To the best of our knowledge, there are no appropriate diagnostic models that can differentiate human MERS-CoV infection among other respiratory infections. Therefore, we recommend the adoption of this newly established model of MERS-CoV to short-list corona suspected cases in Saudi Arabia. © 2020 Rania Ali El Hadi Mohamed et al.",Clinical features; Co-morbidities; Combined features; Coronavirus; MERS-CoV,,"Alserehi, H., Wali, G., Alshukairi, A., Alraddadi, B., Impact of Middle East Respiratory Syndrome coronavirus (MERS CoV) on pregnancy and perinatal outcome (2016) BMC Infect. Dis, 16 (1); Ma, L., Zeng, F., Huang, B., Cong, F., Huang, R., Ma, J., Guo, P., Development of a conventional RT-PCR assay for rapid detection of porcine deltacoronavirus with the same detection limit as a SYBR green-based real-time RT-PCR assay (2018) Biomed Res. Int, 2018; Huang, P., Wang, H., Cao, Z., Jin, H., Chi, H., A rapid and specific assay for the detection of MERS-CoV (2018) Front. Microbiol., 9; Bruning, A.H.L., Aatola, H., Toivola, H., Ikonen, N., Savolainen-Kopra, C., Rapid detection and monitoring of human coronavirus infections (2018) New Microbes New Infect, 24, pp. 52-55; Hemida, M.G., Middle East respiratory syndrome coronavirus and the one health concept (2019) Peerj, 7; Middle East Respiratory Syndrome (MERS) (2016) National Center for Immunization and Respiratory Diseases (NCIRD), , https://www.cdc.gov/ncird/index.html, Division of Viral Diseases; Severe respiratory illness associated with a novel coronavirus-Saudi Arabia and Qatar (2012) MMWR Morb. Mortal. Wkly. Rep., 61, p. 820; Al Mutair, A., Ambani, Z., Narrative review of Middle East respiratory syndrome coronavirus (MERS-CoV) infection: Updates and implications for practice (2019) J. Int. Med. Res.; Raftery, A.T., Lim, E., Östör, A., (2014) Churchill's Pocketbook of Differential Diagnosis. 4Th Edn, , Elsevier, Philadelphia; (2017) Key Facts about Influenza (Flu). National Center for Immunization and Respiratory Diseases (NCIRD), , https://www.cdc.gov/flu/keyfacts.htm; High, K.P., Bradley, S.F., Gravenstein, S., Mehr, D.R., Quagliarello, V.J., Richards, C., Yoshikawa, T.T., Clinical practice guideline for the evaluation of fever and infection in older adult residents of long-term care facilities: 2008 update by the infectious diseases society of America (2009) Clin. Infect. Dis., 48, pp. 149-171; Rushton, C.A., Kadam, U.T., Impact of non-cardiovascular disease comorbidity on cardiovascular disease symptom severity: A population-based study (2014) Int. J. Cardiol., 175, pp. 154-161; (2009) Disease Handbook for Childcare Providers. Division of Public Health Services, p. 2009. , Communicable Disease Control Section, Revised‒April; Assiri, A., Al-Tawfiq, J.A., Al-Rabeeah, A.A., Al-Rabiah, F.A., Al-Hajjar, S., Epidemiological, demographic and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: A descriptive study (2013) Lancet Infect. Dis., 13, pp. 752-761","Mohamed, R.A.E.H.; Department of Biology, College of Science, Princess Nourah Bint Abdulrahman UniversitySaudi Arabia",,Asian Network for Scientific Information,10288880,,,31944070,English,Pak. J. Biol. Sci.,Article,Final,Open Access,Scopus,2-s2.0-85077518368,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhang Y., Cao L., Xu Z., Zhu P., Huang B., Li K., Xu Y., Zhang Z., Wu Y., Di B.",57214255280;57208928019;57211538257;57211534212;57215095162;24402715500;57214744249;57211539928;57191756580;6602190900;,Evaluation of a multiplex PCR assay for detection of respiratory viruses and Mycoplasma pneumoniae in oropharyngeal swab samples from outpatients,2020,Journal of Clinical Laboratory Analysis,34,1, e23032,,,,,10.1002/jcla.23032,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85074348022&doi=10.1002%2fjcla.23032&partnerID=40&md5=af70239e30cc4ae127b99f3a2d6b6821,"Guangzhou Center for Disease Control and Prevention, Guangzhou, China; Ningbo Health Gene Technologies Co., Ltd, Ningbo, China","Zhang, Y., Guangzhou Center for Disease Control and Prevention, Guangzhou, China; Cao, L., Guangzhou Center for Disease Control and Prevention, Guangzhou, China; Xu, Z., Ningbo Health Gene Technologies Co., Ltd, Ningbo, China; Zhu, P., Guangzhou Center for Disease Control and Prevention, Guangzhou, China; Huang, B., Guangzhou Center for Disease Control and Prevention, Guangzhou, China; Li, K., Guangzhou Center for Disease Control and Prevention, Guangzhou, China; Xu, Y., Guangzhou Center for Disease Control and Prevention, Guangzhou, China; Zhang, Z., Guangzhou Center for Disease Control and Prevention, Guangzhou, China; Wu, Y., Ningbo Health Gene Technologies Co., Ltd, Ningbo, China; Di, B., Guangzhou Center for Disease Control and Prevention, Guangzhou, China","Background: Respiratory viruses, such as influenza viruses, initially infect the upper airways but can manifest as severe lower respiratory tract infections in high-risk patients with significant morbidity and mortality. For syndromic diagnosis, several multiplex nucleic acid amplification tests have been developed for clinics, of which SureX 13 Respiratory Pathogen Multiplex Kit (ResP) can simultaneously detect 13 pathogens directly from airway secretion specimens. The organisms identified are influenza virus A, influenza virus A pdmH1N1 (2009), influenza virus A H3N2, influenza virus B, adenovirus, boca virus, rhinovirus, parainfluenza virus, coronavirus, respiratory syncytial virus, human metapneumovirus, Mycoplasma pneumoniae, and Chlamydia. Methods: This study provides performance evaluation data of this assay by comparing with pathogen-specific PCRs from oropharyngeal swab samples. Results: Ten pathogens were detected in this assay, of which rhinovirus, adenovirus, and influenza virus A pdmH1N1 (2009) were the most common. The overall agreement between the ResP and the comparator tests was 93.8%. The ResP demonstrated 86.5% agreement for positive results and 97.8% agreement for negative results. Conclusion: The ResP assay demonstrated a highly concordant performance comparing with pathogen-specific PCRs for detection of respiratory pathogens in oropharyngeal swabs from outpatients and could aid in the diagnosis of respiratory infections in a variety of clinical scenarios. © 2019 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals, Inc.",acute respiratory infections; influenza virus A; multiplex PCR; oropharyngeal swab; respiratory virus,Adenoviridae; adolescent; adult; Article; bacterium detection; Bocaparvovirus; child; controlled study; female; human; Human metapneumovirus; Human respiratory syncytial virus; Influenza A virus (H1N1); Influenza A virus (H3N2); Influenza B virus; male; multiplex polymerase chain reaction; Mycoplasma pneumoniae; nonhuman; oropharynx; outpatient; Paramyxovirinae; respiratory virus; Rhinovirus; virus detection,"Liu, L., Oza, S., Hogan, D., Global, regional, and national causes of under-5 mortality in 2000–15: an updated systematic analysis with implications for the Sustainable Development Goals (2016) Lancet, 388, pp. 3027-3035; Jain, S., Williams, D.J., Arnold, S.R., Community-acquired pneumonia requiring hospitalization among U.S. children (2015) N Engl J Med, 372, pp. 835-845; Self, W.H., Williams, D.J., Zhu, Y., Respiratory viral detection in children and adults: comparing asymptomatic controls and patients with community-acquired pneumonia (2016) J Infect Dis, 213, pp. 584-591; Rappo, U., Schuetz, A.N., Jenkins, S.G., Impact of early detection of respiratory viruses by multiplex PCR assay on clinical outcomes in adult patients. Caliendo AM, ed (2016) J Clin Microbiol, 54, pp. 2096-2103; Ramanan, P., Bryson, A.L., Binnicker, M.J., Pritt, B.S., Patel, R., Syndromic panel-based testing in clinical microbiology (2018) Clin Microbiol Rev, 31, pp. e00024-e117; Subramony, A., Zachariah, P., Krones, A., Impact of multiplex polymerase chain reaction testing for respiratory pathogens on healthcare resource utilization for pediatric inpatients (2016) J Pediatr, 173, pp. 196-201.e2; Rogers, B.B., Shankar, P., Jerris, R.C., Impact of a rapid respiratory panel test on patient outcomes (2015) Arch Pathol Lab Med, 139, pp. 636-641; Brendish, N.J., Malachira, A.K., Armstrong, L., Routine molecular point-of-care testing for respiratory viruses in adults presenting to hospital with acute respiratory illness (ResPOC): a pragmatic, open-label, randomised controlled trial (2017) Lancet Respir Med, 5, pp. 401-411; Landis, J.R., Koch, G.G., The measurement of observer agreement for categorical data (1977) Biometrics, 33, pp. 159-174; Wang, S., Yang, F., Li, D., Clinical application of a multiplex genetic pathogen detection system remaps the aetiology of diarrhoeal infections in Shanghai (2018) Gut Pathogens, 10, p. 37; Vallières, E., Renaud, C., Clinical and economical impact of multiplex respiratory virus assays (2013) Diagn Microbiol Infect Dis, 76, pp. 255-261; Uyeki, T.M., Bernstein, H.H., Bradley, J.S., Clinical Practice Guidelines by the Infectious Diseases Society of America: 2018 Update on Diagnosis, Treatment, Chemoprophylaxis, and Institutional Outbreak Management of Seasonal Influenza (2019) Clin Infect Dis, 68, pp. e1-e47; Zhang, H., Cheng, H., Wang, Q., An advanced fragment analysis-based individualized subtype classification of pediatric acute lymphoblastic leukemia (2015) Sci Rep, 5, p. 12435; Wang, L., Zhao, M., Shi, Z., A GeXP-based assay for simultaneous detection of multiple viruses in hospitalized children with community acquired pneumonia (2016) PLoS ONE, 11; Xie, Z., Luo, S., Xie, L., Simultaneous typing of nine avian respiratory pathogens using a novel GeXP analyzer-based multiplex PCR assay (2014) J Virol Methods, 207, pp. 188-195; Wu, Z.-Q., Zhang, Y., Zhao, N., Comparative epidemiology of human fatal infections with novel, high (H5N6 and H5N1) and low (H7N9 and H9N2) pathogenicity avian influenza A viruses (2017) Int J Environ Res Public Health, 14 (3), p. 263; Pan, M., Gao, R., Lv, Q., Human infection with a novel, highly pathogenic avian influenza A (H5N6) virus: virological and clinical findings (2016) J Infect, 72, pp. 52-59; Qin, Y., Horby, P.W., Tsang, T.K., Differences in the epidemiology of human cases of Avian Influenza A(H7N9) and A(H5N1) viruses infection (2015) Clin Infect Dis, 61, pp. 563-571; Zhang, H., Chen, X., Lyu, F., Detection of viral and atypical pathogens in children with lower respiratory tract infection by multiple PCR technique (2017) J Wenzhou Med Univ, 47, pp. 791-800; Li, X., Chen, B., Zhang, S., Rapid detection of respiratory pathogens for community-acquired pneumonia by capillary electrophoresis-based multiplex PCR (2019) SLAS Technol, 24, pp. 105-116","Di, B.; Guangzhou Center for Disease Control and PreventionChina; email: biao65di@yahoo.com",,John Wiley and Sons Inc.,8878013,,JCANE,31628684,English,J. Clin. Lab. Anal.,Article,Final,Open Access,Scopus,2-s2.0-85074348022,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Kucharski A.J., Russell T.W., Diamond C., Liu Y., Edmunds J., Funk S., Eggo R.M., Sun F., Jit M., Munday J.D., Davies N., Gimma A., van Zandvoort K., Gibbs H., Hellewell J., Jarvis C.I., Clifford S., Quilty B.J., Bosse N.I., Abbott S., Klepac P., Flasche S., Centre for Mathematical Modelling of Infectious Diseases COVID-19 working group",54883807400;57215682390;57215681790;57215550912;35195808200;26634997200;36113351400;57215694535;23990626200;57204002102;57215683897;57215690500;57205317048;57215693252;56899332800;56740337000;51663266700;57215125608;57215684535;57215686681;6603012281;36096719400;,Early dynamics of transmission and control of COVID-19: a mathematical modelling study,2020,The Lancet Infectious Diseases,,,,,,,2,10.1016/S1473-3099(20)30144-4,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082189367&doi=10.1016%2fS1473-3099%2820%2930144-4&partnerID=40&md5=274435ce53ebac9ea15eba4a15c59769,"Centre for Mathematical Modelling of Infectious Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom","Kucharski, A.J., Centre for Mathematical Modelling of Infectious Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom; Russell, T.W., Centre for Mathematical Modelling of Infectious Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom; Diamond, C., Centre for Mathematical Modelling of Infectious Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom; Liu, Y., Centre for Mathematical Modelling of Infectious Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom; Edmunds, J., Centre for Mathematical Modelling of Infectious Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom; Funk, S., Centre for Mathematical Modelling of Infectious Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom; Eggo, R.M., Centre for Mathematical Modelling of Infectious Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom; Sun, F.; Jit, M.; Munday, J.D.; Davies, N.; Gimma, A.; van Zandvoort, K.; Gibbs, H.; Hellewell, J.; Jarvis, C.I.; Clifford, S.; Quilty, B.J.; Bosse, N.I.; Abbott, S.; Klepac, P.; Flasche, S.; Centre for Mathematical Modelling of Infectious Diseases COVID-19 working group","Background: An outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to 95 333 confirmed cases as of March 5, 2020. Understanding the early transmission dynamics of the infection and evaluating the effectiveness of control measures is crucial for assessing the potential for sustained transmission to occur in new areas. Combining a mathematical model of severe SARS-CoV-2 transmission with four datasets from within and outside Wuhan, we estimated how transmission in Wuhan varied between December, 2019, and February, 2020. We used these estimates to assess the potential for sustained human-to-human transmission to occur in locations outside Wuhan if cases were introduced. Methods: We combined a stochastic transmission model with data on cases of coronavirus disease 2019 (COVID-19) in Wuhan and international cases that originated in Wuhan to estimate how transmission had varied over time during January, 2020, and February, 2020. Based on these estimates, we then calculated the probability that newly introduced cases might generate outbreaks in other areas. To estimate the early dynamics of transmission in Wuhan, we fitted a stochastic transmission dynamic model to multiple publicly available datasets on cases in Wuhan and internationally exported cases from Wuhan. The four datasets we fitted to were: daily number of new internationally exported cases (or lack thereof), by date of onset, as of Jan 26, 2020; daily number of new cases in Wuhan with no market exposure, by date of onset, between Dec 1, 2019, and Jan 1, 2020; daily number of new cases in China, by date of onset, between Dec 29, 2019, and Jan 23, 2020; and proportion of infected passengers on evacuation flights between Jan 29, 2020, and Feb 4, 2020. We used an additional two datasets for comparison with model outputs: daily number of new exported cases from Wuhan (or lack thereof) in countries with high connectivity to Wuhan (ie, top 20 most at-risk countries), by date of confirmation, as of Feb 10, 2020; and data on new confirmed cases reported in Wuhan between Jan 16, 2020, and Feb 11, 2020. Findings: We estimated that the median daily reproduction number (Rt) in Wuhan declined from 2·35 (95% CI 1·15–4·77) 1 week before travel restrictions were introduced on Jan 23, 2020, to 1·05 (0·41–2·39) 1 week after. Based on our estimates of Rt, assuming SARS-like variation, we calculated that in locations with similar transmission potential to Wuhan in early January, once there are at least four independently introduced cases, there is a more than 50% chance the infection will establish within that population. Interpretation: Our results show that COVID-19 transmission probably declined in Wuhan during late January, 2020, coinciding with the introduction of travel control measures. As more cases arrive in international locations with similar transmission potential to Wuhan before these control measures, it is likely many chains of transmission will fail to establish initially, but might lead to new outbreaks eventually. Funding: Wellcome Trust, Health Data Research UK, Bill & Melinda Gates Foundation, and National Institute for Health Research. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license",,,"(2020) Coronavirus disease 2019 (COVID-19). Situation report 24. February 13, 2020, , World Health Organization Geneva; Epidemiological data from the nCoV-2019 outbreak: early descriptions from publicly available data (2020), http://virological.org/t/epidemiological-data-from-the-ncov-2019-outbreak-early-descriptions-from-publicly-available-data/337, (accessed Feb 13, 2020); Camacho, A., Kucharski, A., Aki-Sawyerr, Y., Temporal changes in Ebola transmission in Sierra Leone and implications for control requirements: a real-time modelling study (2015) PLoS Curr, p. 7; Funk, S., Ciglenecki, I., Tiffany, A., The impact of control strategies and behavioural changes on the elimination of Ebola from Lofa County, Liberia (2017) Philos Trans R Soc Lond B Biol Sci, 372, p. 20160302; Riley, S., Fraser, C., Donnelly, C.A., Transmission dynamics of the etiological agent of SARS in Hong Kong: impact of public health interventions (2003) Science, 300, pp. 1961-1966; Viboud, C., Sun, K., Gaffey, R., The RAPIDD Ebola forecasting challenge: synthesis and lessons learnt (2018) Epidemics, 22, pp. 13-21; Cooper, B.S., Pitman, R.J., Edmunds, W.J., Gay, N.J., Delaying the international spread of pandemic influenza (2006) PLoS Med, 3, p. e212; Kucharski, A.J., Camacho, A., Checchi, F., Evaluation of the benefits and risks of introducing Ebola community care centers, Sierra Leone (2015) Emerg Infect Dis, 21, pp. 393-399; Aylward, B., Barboza, P., Bawo, L., Ebola virus disease in West Africa—the first 9 months of the epidemic and forward projections (2014) N Engl J Med, 371, pp. 1481-1495; Nishiura, H., Klinkenberg, D., Roberts, M., Heesterbeek, J.A.P., Early epidemiological assessment of the virulence of emerging infectious diseases: a case study of an influenza pandemic (2009) PLoS One, 4, p. e6852; Birrell, P.J., De Angelis, D., Presanis, A.M., Evidence synthesis for stochastic epidemic models (2018) Stat Sci, 33, pp. 34-43; Baguelin, M., Flasche, S., Camacho, A., Demiris, N., Miller, E., Edmunds, W.J., Assessing optimal target populations for influenza vaccination programmes: an evidence synthesis and modelling study (2013) PLoS Med, 10, p. e1001527; Dureau, J., Kalogeropoulos, K., Baguelin, M., Capturing the time-varying drivers of an epidemic using stochastic dynamical systems (2013) Biostatistics, 14, pp. 541-555; Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus–infected pneumonia (2020) N Engl J Med, , published online Jan 29; Liu, T., Hu, J., Kang, M., Transmission dynamics of 2019 novel coronavirus (2019-nCoV) (2020) bioRxiv, , published online Feb 13; Situation report mainland China https://datastudio.google.com/u/0/reporting/3ffd36c3-0272-4510-a140-39e288a9f15c, (accessed Jan 30, 2020); Riou, J., Althaus, C.L., Pattern of early human-to-human transmission of Wuhan 2019 novel coronavirus (2019-nCoV), December 2019 to January 2020 (2020) Euro Surveill, , published online Jan 30; Lloyd-Smith, J.O., Schreiber, S.J., Kopp, P.E., Getz, W.M., Superspreading and the effect of individual variation on disease emergence (2005) Nature, 438, pp. 355-359; Kucharski, A.J., Althaus, C.L., The role of superspreading in Middle East respiratory syndrome coronavirus (MERS-CoV) transmission (2015) Euro Surveill, 20, pp. 14-18; Hellewell, J., Abbott, S., Gimma, A., Bosse, N.I., Jarvis, C., Feasibility of controlling 2019-nCoV outbreaks by isolation of cases and contacts (2020) medRxiv, , published online Feb 11; Imai, N., Dorigatti, I., Cori, A., Report 2: estimating the potential total number of novel coronavirus cases in Wuhan City, China https://www.imperial.ac.uk/media/imperial-college/medicine/sph/ide/gida-fellowships/2019-nCoV-outbreak-report-22-01-2020.pdf, (accessed Feb 20, 2020); Pullano, G., Pinotti, F., Valdano, E., Boëlle, P.-Y., Poletto, C., Colizza, V., Novel coronavirus (2019-nCoV) early-stage importation risk to Europe, January 2020 (2020) Euro Surveill, 25, p. 2000057; Lai, S., Bogoch, I.I., Watts, A., Khan, K., Li, Z., Tatem, A., Preliminary risk analysis of 2019 novel coronavirus spread within and beyond China https://www.worldpop.org/events/china, (accessed Jan 30, 2020); Rothe, C., Schunk, M., Sothmann, P., Transmission of 2019-nCoV infection from an asymptomatic contact in Germany (2020) N Engl J Med, , published online Jan 30","Kucharski, A.J.; Centre for Mathematical Modelling of Infectious Diseases, London School of Hygiene & Tropical MedicineUnited Kingdom; email: adam.kucharski@lshtm.ac.uk",,Lancet Publishing Group,14733099,,LIDAB,32171059,English,Lancet Infect. Dis.,Article,Article in Press,Open Access,Scopus,2-s2.0-85082189367,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Craig A.T., Heywood A.E., Hall J.",23979292400;23979838600;57212616455;,Risk of COVID-19 importation to the Pacific islands through global air travel,2020,Epidemiology and Infection,,,,,,,,10.1017/S0950268820000710,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082529058&doi=10.1017%2fS0950268820000710&partnerID=40&md5=dd84a34259d9086ac9779130f9d78eb1,"School of Public Health and Community Medicine, University of New South Wales, Sydney, NSW 2053, Australia","Craig, A.T., School of Public Health and Community Medicine, University of New South Wales, Sydney, NSW 2053, Australia; Heywood, A.E., School of Public Health and Community Medicine, University of New South Wales, Sydney, NSW 2053, Australia; Hall, J., School of Public Health and Community Medicine, University of New South Wales, Sydney, NSW 2053, Australia","On 30 January 2020, WHO declared coronavirus (COVID-19) a global public health emergency. As of 12 March 2020, 125,048 confirmed COVID-19 cases in 118 countries had been reported. On 12 March 2020, the first case in the Pacific islands was reported in French Polynesia; no other Pacific island country or territory has reported cases. The purpose of our analysis is to show how travellers may introduce COVID-19 into the Pacific islands and discuss the role robust health systems play in protecting health and reducing transmission risk. We analyse travel- A nd Global Health Security Index-data using a scoring tool to produce quantitative estimates of COVID-19 importation risk, by departing and arriving country. Our analysis indicates that, as of 12 March 2020, the highest risk air routes by which COVID-19 may be imported into the Pacific islands are from east Asian countries (specifically, China, Korea and Japan) to north Pacific airports (likely Guam, Commonwealth of the Northern Mariana Islands or, to a less extent, Palau); or from China, Japan, Singapore, the United States of America or France to south Pacific ports (likely, Fiji, Papua New Guinea French Polynesia, or New Caledonia). Other importation routes include from other east Asian countries to Guam, and from Australia, New Zealand and other European countries to the south Pacific. The tool provides a useful method for assessing COVID-19 importation risk and may be useful in other settings. © 2020 Cambridge University Press. All rights reserved.",,airport; article; Australia; aviation; China; clinical article; Fiji; France; French Polynesia; global health; Guam; Japan; Korea; New Caledonia; New Zealand; Northern Mariana Islands; Palau; Papua New Guinea; quantitative analysis; risk assessment; Singapore; United States,"Zhu, N., A novel coronavirus from patients with pneumonia in china, 2019 (2020) The New England Journal of Medicine, 382, pp. 727-733; (2005) Emergency Committee Regarding the Outbreak of Novel Coronavirus (2019-nCoV), , World Health Organization Statement on the second meeting of the International Health Regulations, World Health Organization Geneva; 30/01/2020 [cited 2020 Feb 8]; Novel Coronavirus(2019-nCoV): Situation Report-11, , World Health Organization, Geneva: WHO; 31/1/2020; Coronavirus Disease 2019 (2019-nCoV): Situation Report-52, , World Health Organization, Geneva: WHO; 12/3/2020; MacLellan, N., Pacific Islands Hit by First Coronavirus Case after French Polynesian MP Infected on Paris Trip World News, , The Guardian: The Guardian Australian Edition; 13/03/2020 [cited 2020 Mar 13]; Craig, A.T., Early warning epidemic surveillance in the Pacific island nations: An evaluation of the Pacific syndromic surveillance system (2016) Tropical Medicine & International Health, 21, pp. 917-927; Horwood, P.F., Health challenges of the pacific region: Insights from history, geography, social determinants, genetics, and the microbiome (2019) Frontiers in Immunology, 10, p. 2184; Kool, J.L., Pacific-wide simplified syndromic surveillance for early warning of outbreaks (2012) Global Public Health, 7, pp. 670-681; Matheson, D., Park, K., Soakai, T.S., Pacific island health inequities forecast to grow unless profound changes are made to health systems in the region (2017) Australian Health Review [Internet], 41, pp. 590-598; Framework of Action for Revitalization of Healthy Islands in the Pacific, , World Health Organization, WHO. Manila, Philippines: WHO 2013 [cited 2020 Feb 24]; Gilbert, K., Achieving UHC in the Pacific a closer look at implementation: Summary of a Report for Pacific Health Ministers (2019) Health Systems & Reform [Internet], 5, pp. 83-90; Craig, A.T., Short report: 2014 Pacific meeting on implementation of the International Health Regulations (2005) (2015) Western Pacific Surveillance and Response, 6, pp. 92-93; Wilson, N., Modeling the impact of pandemic influenza on Pacific Islands (2005) Emerging Infectious Diseases, 11, pp. 347-349; Roth, A., Concurrent outbreaks of dengue, chikungunya and Zika virus infections-A n unprecedented epidemic wave of mosquito-borne viruses in the Pacific 2012-2014 (2014) Euro Surveillance, p. 19; Craig, A.T., Enhanced surveillance during a public health emergency in a resource-limited setting: Experience from a large dengue outbreak in Solomon Islands 2016-17 (2018) PloS ONE, 13, p. E0198487; Craig, A.T., Heywood, A.E., Worth, H., Measles epidemic in Samoa and other Pacific islands (2020) The Lancet Infectious Diseases, 20, pp. 273-275; Bogoch, I.I., Potential for global spread of a novel coronavirus from China (2020) Journal of Travel Medicine, 11; Haider, N., Passengers' destinations from China: Low risk of Novel Coronavirus (2019-nCoV) transmission into Africa and South America (2020) Epidemiology and Infection, 148, p. E41; Gilbert, M., Preparedness and vulnerability of African countries against importations of COVID-19: A modelling study (2020) The Lancet, 395, pp. 871-877; Cameron, E., Nuzzo, J., Bell, J., (2019) Global Health Security Index: Building Collective Action and Accountability: Nuclear Threats Initiative & John Hopkins Centre for Health Security; NTI and Johns Hopkins University Centre for Health Security, , http://www.ghsindex.org/about/, About-GHS Index [Internet]. Washington: NTI; JHU 2020 [updated 2020 Mar 1; cited 2020 Mar 1]; (2007) Everybody's Business: Strengthening Health Systems to Improve Health Outcomes: WHO's Framework for Action, , World Health Organization, WHO. Geneva: WHO, [cited 2020 Mar 2]; (2020) Pacific Steps up Preparedness against COVID-19 [Internet], , http://www.who.int/westernpacific/about/how-we-work/pacific-support/news/detail/21-02-2020-pacific-steps-up-preparedness-against-covid-19, World Health Organization, Manila, Philippines: WHO, [updated 2020 Feb 21; cited 2020 Mar 12]","Craig, A.T.; School of Public Health and Community Medicine, University of New South WalesAustralia; email: adam.craig@unsw.edu.au",,Cambridge University Press,9502688,,EPINE,32202489,English,Epidemiol. Infect.,Article,Article in Press,Open Access,Scopus,2-s2.0-85082529058,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Peyronnet V., Sibiude J., Deruelle P., Huissoud C., Lescure X., Lucet J.-C., Mandelbrot L., Nisand I., Vayssière C., Yazpandanah Y., Luton D., Picone O.",57190288437;40561810500;6602586697;23667293000;7801685877;7006655229;7005118217;7006739930;6701630807;56653460200;56220662200;13605603800;,SARS-CoV-2 infection during pregnancy. Information and proposal of management care. CNGOF [Infection par le SARS-CoV-2 chez les femmes enceintes. État des connaissances et proposition de prise en charge. CNGOF],2020,Gynecologie Obstetrique Fertilite et Senologie,,,,,,,,10.1016/j.gofs.2020.03.014,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082517531&doi=10.1016%2fj.gofs.2020.03.014&partnerID=40&md5=48e5b9a0116fde55b6dbaae0cf194c5c,"Service de gynécologie-obstétrique Colombes, Assistance publique–Hôpitaux de Paris, hôpital Louis-Mourier, université de Paris, Colombes, 92700, France; Inserm IAME-U1137, Paris, 75000, France; Groupe de recherche sur les infections pendant la grossesse (GRIG), Paris, 75000, France; Hôpital Paule-de-Viguier, CHU de Toulouse, Toulouse, 31000, France; Équipe SPHERE, Inserm UMR1027, université Toulouse III, Toulouse, 31000, France; University Lyon, University Claude-Bernard Lyon 1, Villeurbanne, 69100, France; Hospices civils de Lyon, hôpital de la Croix-Rousse, Lyon, 69004, France; Inserm U846, stem cell and brain research institute, 18, avenue Doyen-Lepine, Bron, 69500, France; Service de maladies infectieuses et tropicales, hôpital Bichat Claude-Bernard, université de Paris, AP–HP, 46, rue Henri-Huchard, Paris, 75018, France; Service de gynécologie obstétrique, maternité Aline-de-Crepy, FHU Prematurity INSERM U1016, hôpital Bichat APHP, université de Paris, Institut Imagine, Paris, 75018, France; CNGOF, 91, boulevard de Sébastopol, Paris, 75002, France; Infection Control Unit, Bichat University Hospital, Assistance publique–Hôpitaux de Paris, université de Paris, Paris, 75018, France; Service de gynécologie obstétrique, hôpitaux universitaires de Strasbourg, Strasbourg, 67000, France","Peyronnet, V., Service de gynécologie-obstétrique Colombes, Assistance publique–Hôpitaux de Paris, hôpital Louis-Mourier, université de Paris, Colombes, 92700, France, Infection Control Unit, Bichat University Hospital, Assistance publique–Hôpitaux de Paris, université de Paris, Paris, 75018, France; Sibiude, J., Service de gynécologie-obstétrique Colombes, Assistance publique–Hôpitaux de Paris, hôpital Louis-Mourier, université de Paris, Colombes, 92700, France, Inserm IAME-U1137, Paris, 75000, France, Groupe de recherche sur les infections pendant la grossesse (GRIG), Paris, 75000, France, CNGOF, 91, boulevard de Sébastopol, Paris, 75002, France, Infection Control Unit, Bichat University Hospital, Assistance publique–Hôpitaux de Paris, université de Paris, Paris, 75018, France; Deruelle, P., CNGOF, 91, boulevard de Sébastopol, Paris, 75002, France, Infection Control Unit, Bichat University Hospital, Assistance publique–Hôpitaux de Paris, université de Paris, Paris, 75018, France, Service de gynécologie obstétrique, hôpitaux universitaires de Strasbourg, Strasbourg, 67000, France; Huissoud, C., University Lyon, University Claude-Bernard Lyon 1, Villeurbanne, 69100, France, Hospices civils de Lyon, hôpital de la Croix-Rousse, Lyon, 69004, France, Inserm U846, stem cell and brain research institute, 18, avenue Doyen-Lepine, Bron, 69500, France, CNGOF, 91, boulevard de Sébastopol, Paris, 75002, France, Infection Control Unit, Bichat University Hospital, Assistance publique–Hôpitaux de Paris, université de Paris, Paris, 75018, France; Lescure, X., Inserm IAME-U1137, Paris, 75000, France, Service de maladies infectieuses et tropicales, hôpital Bichat Claude-Bernard, université de Paris, AP–HP, 46, rue Henri-Huchard, Paris, 75018, France, Infection Control Unit, Bichat University Hospital, Assistance publique–Hôpitaux de Paris, université de Paris, Paris, 75018, France; Lucet, J.-C., Inserm IAME-U1137, Paris, 75000, France, Infection Control Unit, Bichat University Hospital, Assistance publique–Hôpitaux de Paris, université de Paris, Paris, 75018, France; Mandelbrot, L., Service de gynécologie-obstétrique Colombes, Assistance publique–Hôpitaux de Paris, hôpital Louis-Mourier, université de Paris, Colombes, 92700, France, Inserm IAME-U1137, Paris, 75000, France, Groupe de recherche sur les infections pendant la grossesse (GRIG), Paris, 75000, France, CNGOF, 91, boulevard de Sébastopol, Paris, 75002, France, Infection Control Unit, Bichat University Hospital, Assistance publique–Hôpitaux de Paris, université de Paris, Paris, 75018, France; Nisand, I., CNGOF, 91, boulevard de Sébastopol, Paris, 75002, France, Infection Control Unit, Bichat University Hospital, Assistance publique–Hôpitaux de Paris, université de Paris, Paris, 75018, France; Vayssière, C., Hôpital Paule-de-Viguier, CHU de Toulouse, Toulouse, 31000, France, Équipe SPHERE, Inserm UMR1027, université Toulouse III, Toulouse, 31000, France, CNGOF, 91, boulevard de Sébastopol, Paris, 75002, France, Infection Control Unit, Bichat University Hospital, Assistance publique–Hôpitaux de Paris, université de Paris, Paris, 75018, France; Yazpandanah, Y., Inserm IAME-U1137, Paris, 75000, France, Service de maladies infectieuses et tropicales, hôpital Bichat Claude-Bernard, université de Paris, AP–HP, 46, rue Henri-Huchard, Paris, 75018, France, Infection Control Unit, Bichat University Hospital, Assistance publique–Hôpitaux de Paris, université de Paris, Paris, 75018, France; Luton, D., Service de gynécologie obstétrique, maternité Aline-de-Crepy, FHU Prematurity INSERM U1016, hôpital Bichat APHP, université de Paris, Institut Imagine, Paris, 75018, France, CNGOF, 91, boulevard de Sébastopol, Paris, 75002, France, Infection Control Unit, Bichat University Hospital, Assistance publique–Hôpitaux de Paris, université de Paris, Paris, 75018, France; Picone, O., Service de gynécologie-obstétrique Colombes, Assistance publique–Hôpitaux de Paris, hôpital Louis-Mourier, université de Paris, Colombes, 92700, France, Inserm IAME-U1137, Paris, 75000, France, Groupe de recherche sur les infections pendant la grossesse (GRIG), Paris, 75000, France, CNGOF, 91, boulevard de Sébastopol, Paris, 75002, France, Infection Control Unit, Bichat University Hospital, Assistance publique–Hôpitaux de Paris, université de Paris, Paris, 75018, France","A new coronavirus (SARS-CoV-2) highlighted at the end of 2019 in China is spreading across all continents. Most often at the origin of a mild infectious syndrome, associating mild symptoms (fever, cough, myalgia, headache and possible digestive disorders) to different degrees, SARS-Covid-2 can cause serious pulmonary pathologies and sometimes death. Data on the consequences during pregnancy are limited. The first Chinese data published seem to show that the symptoms in pregnant women are the same as those of the general population. There are no cases of intrauterine maternal-fetal transmission, but cases of newborns infected early suggest that there could be vertical perpartum or neonatal transmission. Induced prematurity and cases of respiratory distress in newborns of infected mothers have been described. Pregnancy is known as a period at higher risk for the consequences of respiratory infections, as for influenza, so it seems important to screen for Covid-19 in the presence of symptoms and to monitor closely pregnant women. In this context of the SARS-Covid-2 epidemic, the societies of gynecology-obstetrics, infectious diseases and neonatalogy have proposed a French protocol for the management of possible and proven cases of SARS-Covid-2 in pregnant women. These proposals may evolve on a daily basis with the advancement of the epidemic and knowledge in pregnant women. Subsequently, an in-depth analysis of cases in pregnant women will be necessary in order to improve knowledge on the subject. © 2020 Elsevier Masson SAS",Coronavirus SARS-CoV-2; COVID-19; Maternal-fetal transmission; Newborn; Pregnancy,,"Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382 (8), pp. 727-733; Hui, D.S., Epidemic and Emerging Coronaviruses (Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome) (2017) Clin Chest Med, 38 (1), pp. 71-86; Song, Z., Xu, Y., Bao, L., Zhang, L., Yu, P., Qu, Y., From SARS to MERS, thrusting coronaviruses into the spotlight (2019) Viruses, 11 (1). , pii: E59; Lu, R., Zhao, X., Li, J., Niu, P., Yang, B., Wu, H., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet, 395 (10224), pp. 565-574; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395 (10223), pp. 497-506; Guan, W.J., Ni, Z.Y., Hu, Y., Liang, W.-H., Ou, C.-Q., He, J.-X., Clinical characteristics of Coronavirus Disease 2019 in China (2020) N Engl J Med, , NEJMoa2002032; Liu, Y., Chen, H., Tang, K., Guo, Y., Clinical manifestations and outcome of SARS-CoV-2 infection during pregnancy (2020) J Infect; Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Clinical Characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) JAMA; Dorigatti, I., Okell, L., Cori, A., https://www.imperial.ac.uk/media/imperial-college/medicine/sph/ide/gidafellowships/Imperial-College-2019-nCoV-severity-10-02-2020.pdf, Report 4: Severity of 2019-novel coronavirus (nCoV). WHO Collaborating Centre for Infectious Disease Modelling, MRC Centre for Global Infectious Disease Analysis, Imperial College London. Available from: (Accessed March 15, 2020); Rasmussen, S.A., Smulian, J.C., Lednicky, J.A., Wen, T.S., Jamieson, D.J., Coronavirus Disease 2019 (COVID-19) and pregnancy: what obstetricians need to know (2020) Am J Obstet Gynecol; Shen, K.L., Yang, Y.-H., Diagnosis and treatment of 2019 novel coronavirus infection in children: a pressing issue (2020) World J Pediatr; Han, Y., Yang, H., The transmission and diagnosis of 2019 novel coronavirus infection disease (COVID-19): a Chinese perspective (2020) J Med Virol., , jmv.25749; Chen, H., Guo, J., Wang, C., Luo, F., Yu, X., Zhang, W., Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records (2020) Lancet, 395 (10226), pp. 809-815; Wang, X., Zhou, Z., Zhang, J., Zhu, F., Tang, Y., Shen, X., A case of 2019 Novel Coronavirus in a pregnant woman with preterm delivery (2020) Clin Infect Dis.; Zhu, H., Wang, L., Fang, C., Peng, S., Zhang, L., Chang, G., Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia (2020) Transl Pediatr, 9 (1), pp. 51-60; Schwartz, D.A., Graham, A.L., Potential maternal and infant outcomes from (Wuhan) Coronavirus 2019-nCoV infecting pregnant women: lessons from SARS, MERS, and other human coronavirus infections (2020) Viruses, 12 (2). , pii: E194; Rigby, F.B., Pastorek, J.G., Pneumonia during pregnancy (1996) Clin Obstet Gynecol, 39 (1), pp. 107-119; Madinger, N.E., Greenspoon, J.S., Ellrodt, A.G., Pneumonia during pregnancy: has modern technology improved maternal and fetal outcome? (1989) Obstet Gynecol, 161 (3), pp. 657-662; Jamieson, D.J., Theiler, R.N., Rasmussen, S.A., Emerging infections and pregnancy. Emerging Infectious Diseases (2006) Cent Dis Contr Prev (CDC), 12 (11), pp. 1638-1643; Warning, J.C., McCracken, S.A., Morris, J.M., A balancing act: mechanisms by which the fetus avoids rejection by the maternal immune system (2011) Reproduction, 141 (6), pp. 715-724; Nyhan, D., Quigley, C., Bredin, C.P., Acute respiratory failure in pregnancy due to staphylococcal pneumonia (1983) Ir Med J, 76 (7), pp. 320-321; Weinberger, S.E., Weiss, S.T., Cohen, W.R., Weiss, J.W., Johnson, T.S., Pregnancy and the lung (1980) Am Rev Resp Dis, 121, pp. 559-581; Sargent, I.L., Redman, C., Immunobiologic adaptations of pregnancy (1992) Medicine of the Fetus and Mother, pp. 317-327. , E.A. Reece J.C. Hobbins M.J. Mahoney R.H. Petrie JB Lippincott Company Philadelphia, PA, USA; Siston, A.M., Rasmussen, S.A., Honein, M.A., Fry, A.M., Seib, K., Callaghan, W.M., Pandemic 2009 influenza A(H1N1) virus illness among pregnant women in the United States (2010) JAMA, 303 (15), pp. 1517-1525; Benedetti, T.J., Valle, R., Ledger, W.J., Antepartum pneumonia in pregnancy (1982) Am J Obstet Gynecol, 144 (4), pp. 413-417; Berkowitz, K., LaSala, A., Risk factors associated with the increasing prevalence of pneumonia during pregnancy (1990) Am J Obstet Gynecol, 163 (3), pp. 981-985; Hui, D.S.C., Zumla, A., Severe acute respiratory syndrome: historical, epidemiologic, and clinical features (2019) Infect Dis Clin N Am, 33 (4), pp. 869-889; Wong, S.F., Chow, K.M., de Swiet, M., Severe acute respiratory syndrome and pregnancy (2003) BJOG, 110 (7), pp. 641-642; Zhang, J., Wang, Y., Chen, L., Zhang, R., Xie, Y., Clinical analysis of pregnancy in second and third trimesters complicated severe acute respiratory syndrome (2003) Zhonghua Fu Chan Ke Za Zhi, 38 (8), pp. 516-520; Yang, H., Wang, C., Poon, L.C., Novel coronavirus infection and pregnancy (2020) Ultrasound Obstet Gynecol; Zheng, Q.L., Duan, T., Jin, L.P., Single-cell RNA expression profiling of ACE2 and AXL in the human maternal–fetal interface (2020) Reprod Dev Med, , http://www.repdevmed.org/preprintarticle.asp?id=278679, [Epub ahead of print] [cited 2020 Mar 17]. Available from:; Chen, S., Huang, B., Luo, D.J., Li, X., Yang, F., Zhao, Y., Pregnant women with new coronavirus infection: a clinical characteristics and placental pathological analysis of three cases (2020) Zhonghua Bing Li Xue Za Zhi, 49 (0), p. E005; Steinbuch, Y., Chinese Baby Tests Positive for Coronavirus 30 Hours after Birth. New York post [online] (2020), https://nypost.com/2020/02/05/chinese-baby-tests-positive-for-coronavirus-30-hours-after-birth/, Available from: [accessed 15 March 2020]; Woodward, A., A Pregnant Mother Infected with the Coronavirus Gave Birth, and Her Baby Tested Positive 30 Hours Later (2020), https://www.businessinsider.com/wuhan-coronavirus-in-infant-bornfrom-infected-mother-2020-2, Business insider, India [online] Available online: [accessed 15 March 2020]; Gillespie, T., Coronavirus: doctors fear pregnant women can pass on illness after newborn baby is diagnosed (2020), https://news.sky.com/story/coronavirus-doctors-fear-pregnant-women-canpass-on-illness-after-newborn-baby-is-diagnosed-11926968, Sky news [online] Available online: (accessed 15 March 2020); Schwartz, D.A., Being pregnant during the kivu ebola virus outbreak in DR Congo: the rVSV-ZEBOV vaccine and its accessibility by mothers and infants during humanitarian crises and in conflict areas (2020) Vaccines, 8 (1). , pii: E38; Alvarado, M.G., Schwartz, D.A., Zika virus infection in pregnancy, microcephaly, and maternal and fetal health: what we think, what we know, and what we think we know (2017) Arch Pathol Lab Med, 141 (1), pp. 26-32; Ng, P.C., Leung, C., Chiu, W.K., Wong, S.F., Hon, E.K.L., SARS in newborns and children (2004) Biol Neonate, 85 (4), pp. 293-298; Robertson, C.A., Lowther, S.A., Birch, T., Tan, C., Sorhage, F., Stockman, L., SARS and pregnancy: a case report (2004) Emerg Infect Dis, 10 (2), pp. 345-348; Stockman, L.J., Lowther, S.A., Coy, K., Saw, J., Parashar, U.D., SARS during pregnancy (2004) Emerg Infect Dis, 10 (9), pp. 1689-1690; Alserehi, H., Wali, G., Alshukairi, A., Alraddadi, B., Impact of Middle East Respiratory Syndrome coronavirus (MERS-CoV) on pregnancy and perinatal outcome (2016) BMC Infect Dis, 16 (1), p. 105; Coronavirus (COVID-19) infection and pregnancy–RCOG. Version 1 (2020), https://www.rcog.org.uk/globalassets/documents/guidelines/coronavirus-covid-19-virus-infection-in-pregnancy-2020-03-09.pdf, Available from: (Accessed 15 March 2020); Poon, L.C., Yang, H., Lee, J.C.S., Copel, J.A., Leung, T.Y., Zhang, Y., ISUOG Interim Guidance on 2019 novel coronavirus infection during pregnancy and puerperium: information for healthcare professionals (2020) Ultrasound Obstet Gynecol.","Picone, O.; Department of Gynaecology and Obstetrics, hôpital Louis-Mourier, Colombes, hôpitaux universitaires Paris Nord Val-de-Seine, Assistance publique des Hôpitaux de Paris, université Paris-DiderotFrance; email: olivier.picone@aphp.fr",,Elsevier Masson SAS,24687197,,,32199996,English; French,Gynecol. Obstet. Fertil. Senologie,Article,Article in Press,Open Access,Scopus,2-s2.0-85082517531,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Sun P., Qie S., Liu Z., Ren J., Li K., Xi J.",57214371381;57199507148;57215601448;57215612356;57215605922;57216114801;,Clinical characteristics of 50 466 hospitalized patients with 2019-nCoV infection,2020,Journal of Medical Virology,,,,,,,3,10.1002/jmv.25735,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081336819&doi=10.1002%2fjmv.25735&partnerID=40&md5=165ce7234b5fe0bf9c23548745a702f1,"Department of Plastic Surgery, Zibo Central Hospital, Zibo, China; Department of Rehabilitation, Beijing Rehabilitation Hospital of Capital Medical University, Beijing, China; Department of Plastic Surgery, Affiliated Hospital of Qingdao University, Qingdao, China; Department of Plastic Surgery, Qingdao Eighth People's Hospital, Qingdao, China; Department of Respiratory Rehabilitation, Beijing Rehabilitation Hospital of Capital Medical University, Beijing, China","Sun, P., Department of Plastic Surgery, Zibo Central Hospital, Zibo, China; Qie, S., Department of Rehabilitation, Beijing Rehabilitation Hospital of Capital Medical University, Beijing, China; Liu, Z., Department of Rehabilitation, Beijing Rehabilitation Hospital of Capital Medical University, Beijing, China; Ren, J., Department of Plastic Surgery, Affiliated Hospital of Qingdao University, Qingdao, China; Li, K., Department of Plastic Surgery, Qingdao Eighth People's Hospital, Qingdao, China; Xi, J., Department of Respiratory Rehabilitation, Beijing Rehabilitation Hospital of Capital Medical University, Beijing, China","We aim to summarize reliable evidence of evidence-based medicine for the treatment and prevention of the 2019 novel coronavirus (2019-nCoV) by analyzing all the published studies on the clinical characteristics of patients with 2019-nCoV. PubMed, Cochrane Library, Embase, and other databases were searched. Several studies on the clinical characteristics of 2019-nCoV infection were collected for meta-analysis. Ten studies were included in the meta-analysis, including a total number of 50 466 patients with 2019-nCoV infection. Meta-analysis shows that among these patients, the incidence of fever was 89.1%, the incidence of cough was 72.2%, and the incidence of muscle soreness or fatigue was 42.5%. The incidence of acute respiratory distress syndrome (ARDS) was 14.8%, the incidence of abnormal chest computer tomography (CT) was 96.6%, the percentage of severe cases in all infected cases was 18.1%, and the case fatality rate of patients with 2019-nCoV infection was 4.3%. Fever and cough are the most common symptoms in patients with 2019-nCoV infection, and most of these patients have abnormal chest CT examination. Several people have muscle soreness or fatigue as well as ARDS. Diarrhea, hemoptysis, headache, sore throat, shock, and other symptoms only occur in a small number of patients. The case fatality rate of patients with 2019-nCoV infection is lower than that of the severe acute respiratory syndrome and Middle East respiratory syndrome. © 2020 Wiley Periodicals, Inc.",2019-nCoV; clinical symptoms; coronavirus; meta-analysis,,"Lancet, T., Emerging understandings of 2019-nCoV (2020) Lancet, 395 (10221), p. 311; Lu, H., Stratton, C.W., Tang, Y.W., Outbreak of pneumonia of unknown etiology in Wuhan China: the mystery and the miracle (2020) J Med Virol, 92, pp. 401-402. , https://doi.org/10.1002/jmv.25678; Moher, D., Liberati, A., Tetzlaff, J., Altman, D.G., Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement (2009) J Clin Epidemiol, 62 (10), pp. 1006-1012; Stang, A., Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses (2010) Eur J Epidemiol, 25 (9), pp. 603-605; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506; 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Li, J., Li, S., Cai, Y., Epidemiological and clinical characteristics of 17 hospitalized patients with 2019 novel coronavirus infections outside Wuhan, China (2020) medRxiv, , https://doi.org/10.1101/2020.02.11.20022053; The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China (2020) Zhonghua Liu Xing Bing Xue Za Zhi, 41, pp. 145-151; Xu, X.W., Wu, X.X., Jiang, X.G., Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series (2020) BMJ, 368; Ji, W., Wang, W., Zhao, X., Zai, J., Li, X., Homologous recombination within the spike glycoprotein of the newly identified coronavirus may boost cross-species transmission from snake to human (2020) J Med Virol, 92, pp. 433-440. , https://doi.org/10.1002/jmv.25682; Xiao, K., Zhai, J., Feng, Y., Isolation and characterization of 2019-nCoV-like coronavirus from Malayan Pangolins (2020) medRxiv, , https://doi.org/10.1101/2020.02.17.951335; 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Xie, L., Liu, Y., Xiao, Y., Follow-up study on pulmonary function and lung radiographic changes in rehabilitating severe acute respiratory syndrome patients after discharge (2005) Chest, 127 (6), pp. 2119-2124; Hui, D.S., Impact of severe acute respiratory syndrome (SARS) on pulmonary function, functional capacity and quality of life in a cohort of survivors (2005) Thorax, 60 (5), pp. 401-409; Zhao, Y., Zhao, Z., Wang, Y., Single-cell RNA expression profiling of ACE2, the putative receptor of Wuhan 2019-nCov (2020) bioRxiv, , https://doi.org/10.1101/2020.01.26.919985; Holshue, M.L., DeBolt, C., Lindquist, S., First case of 2019 novel coronavirus in the United States (2020) N Engl J Med, , https://doi.org/10.1056/NEJMoa2001191; Buret, A.G., Immuno-modulation and anti-inflammatory benefits of antibiotics: the example of tilmicosin (2010) Can J Vet Res, 74 (1), pp. 1-10; Wuyts, W.A., Willems, S., Vos, R., Azithromycin reduces pulmonary fibrosis in a bleomycin mouse model (2010) Exp Lung Res, 36 (10), pp. 602-614; Luo, F., Zhuang, Y., Sides, M.D., Arsenic trioxide inhibits transforming growth factor-β1-induced fibroblast to myofibroblast differentiation in vitro and bleomycin induced lung fibrosis in vivo (2014) Respir Res, 15, p. 51; Chunbin, W., Shuang, Z., Qian, Z., Research progress of two new antifibrotic drugs for idiopathic pulmonary fibrosis (2019) Chin Pharm J, 9, pp. 682-686","Xi, J.; Department of Respiratory Rehabilitation, Beijing Rehabilitation Hospital of Capital Medical UniversityChina; email: zbzbspf@163.com",,John Wiley and Sons Inc.,1466615,,JMVID,32108351,English,J. Med. Virol.,Article,Article in Press,Open Access,Scopus,2-s2.0-85081336819,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Walls A.C., Park Y.-J., Tortorici M.A., Wall A., McGuire A.T., Veesler D.",57159082300;57199902157;6603890184;57211211132;55624659200;25227836200;,"Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein",2020,Cell,,,,,,,1,10.1016/j.cell.2020.02.058,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081283286&doi=10.1016%2fj.cell.2020.02.058&partnerID=40&md5=80e28a5a260e48945b97924e18a5ca41,"Department of Biochemistry, University of Washington, Seattle, WA 98195, United States; Institute Pasteur & CNRS UMR 3569, Unité de Virologie Structurale, Paris, 75015, France; Vaccines and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98195, United States; Department of Global Health, University of Washington, Seattle, WA 98195, United States","Walls, A.C., Department of Biochemistry, University of Washington, Seattle, WA 98195, United States; Park, Y.-J., Department of Biochemistry, University of Washington, Seattle, WA 98195, United States; Tortorici, M.A., Department of Biochemistry, University of Washington, Seattle, WA 98195, United States, Institute Pasteur & CNRS UMR 3569, Unité de Virologie Structurale, Paris, 75015, France; Wall, A., Vaccines and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98195, United States; McGuire, A.T., Vaccines and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98195, United States, Department of Global Health, University of Washington, Seattle, WA 98195, United States; Veesler, D., Department of Biochemistry, University of Washington, Seattle, WA 98195, United States","The emergence of SARS-CoV-2 has resulted in >90,000 infections and >3,000 deaths. Coronavirus spike (S) glycoproteins promote entry into cells and are the main target of antibodies. We show that SARS-CoV-2 S uses ACE2 to enter cells and that the receptor-binding domains of SARS-CoV-2 S and SARS-CoV S bind with similar affinities to human ACE2, correlating with the efficient spread of SARS-CoV-2 among humans. We found that the SARS-CoV-2 S glycoprotein harbors a furin cleavage site at the boundary between the S1/S2 subunits, which is processed during biogenesis and sets this virus apart from SARS-CoV and SARS-related CoVs. We determined cryo-EM structures of the SARS-CoV-2 S ectodomain trimer, providing a blueprint for the design of vaccines and inhibitors of viral entry. Finally, we demonstrate that SARS-CoV S murine polyclonal antibodies potently inhibited SARS-CoV-2 S mediated entry into cells, indicating that cross-neutralizing antibodies targeting conserved S epitopes can be elicited upon vaccination. SARS-CoV-2, a newly emerged pathogen spreading worldwide, binds with high affinity to human ACE2 and uses it as an entry receptor to invade target cells. Cryo-EM structures of the SARS-CoV-2 spike glycoprotein in two distinct conformations, along with inhibition of spike-mediated entry by SARS-CoV polyclonal antibodies, provide a blueprint for the design of vaccines and therapeutics. © 2020 Elsevier Inc.",antibodies; coronavirus; cryo-EM; neutralizing antibodies; SARS-CoV; SARS-CoV-2; spike glycoprotein; viral receptor,,"Agirre, J., Iglesias-Fernández, J., Rovira, C., Davies, G.J., Wilson, K.S., Cowtan, K.D., Privateer: software for the conformational validation of carbohydrate structures (2015) Nat. Struct. Mol. 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Bar-Ilan University, Begin-Sadat Center for Strategic Studies, Ramat Gan, 5290002, Israel","Yamada, M., Laboratory of Animal Health, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8, Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan; Kubota, K., Laboratory of Animal Health, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8, Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan; Takahashi, S., Laboratory of Animal Health, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8, Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan; Toyofuku, C., Laboratory of Animal Health, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8, Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan; Hakim, H., Laboratory of Animal Health, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8, Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan; Alam, M.S., Laboratory of Animal Health, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8, Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan; Hasan, M.A., Laboratory of Animal Health, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8, Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan; Shoham, D., Laboratory of Animal Health, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8, Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan, Bar-Ilan University, Begin-Sadat Center for Strategic Studies, Ramat Gan, 5290002, Israel; Takehara, K., Laboratory of Animal Health, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8, Saiwai-cho, Fuchu-shi, Tokyo, 183-8509, Japan","It can be judged that if the detection frequency of prevalent pathogenic viruses decreases, biosecurity has been enhanced. To monitor bovine farm biosecurity levels, one-step multiplex reverse transcription polymerase chain reaction (RT-PCR) for the simultaneous detection of group A rotavirus (RVA), bovine torovirus (BToV), bovine enterovirus (BEV), and bovine coronavirus (BCV) was designed, with the aim of configuring candidates for “viral pathogen indicators”. A total of 322 bovine fecal samples were collected from calves aged less than three months at 48 bovine farms in Ibaraki and Chiba prefectures. At farm A, 20 calves were selected and sampled weekly for 12 weeks (184 samples); at farm B, 10 calves were selected and sampled for five weeks (50 samples); and at the rest of the 46 farms, 88 calves were sampled once. The screening on the 358 field samples proved positive for 27 RVA, 4 BToV, 55 BEV, and 52 BCV. In the successive sampling, RVA was detected once but not continuously, whereas BEV and BCV were detected in succession for up to five weeks. The results revealed that RVA was the primary agent among the positive samples obtained from calves aged three weeks or less, while BEV was the primary among those from the older than three weeks old. They can be employed as useful viral pathogen indicators for soundly evaluating biosecurity at bovine farms. © 2020 The Japanese Society of Veterinary Science.",Biosecurity; Enterovirus; Multiplex RT-PCR; Rotavirus; Viral pathogen indicator,agricultural land; article; Bovine coronavirus; Bovine enterovirus; calf (mammal); infectious agent; major clinical study; multiplex reverse transcription polymerase chain reaction; nonhuman; Rotavirus; Torovirus,"Blas-Machado, U., Saliki, J.T., Sánchez, S., Brown, C.C., Zhang, J., Keys, D., Woolums, A., Harvey, S.B., Pathogenesis of a bovine enterovirus-1 isolate in experimentally infected calves (2011) Vet. Pathol., 48, pp. 1075-1084; Cho, Y.I., Yoon, K.J., An overview of calf diarrhea-infectious etiology, diagnosis, and intervention (2014) J. Vet. 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Microbiol., 29, pp. 493-497; Kuwabara, M., Wada, K., Maeda, Y., Miyazaki, A., Tsunemitsu, H., First isolation of cytopathogenic bovine torovirus in cell culture from a calf with diarrhea (2007) Clin. Vaccine Immunol., 14, pp. 998-1004; Ley, V., Higgins, J., Fayer, R., Bovine enteroviruses as indicators of fecal contamination (2002) Appl. Environ. Microbiol., 68, pp. 3455-3461; Matthijnssens, J., Rahman, M., van Ranst, M., Two out of the 11 genes of an unusual human G6P[6] rotavirus isolate are of bovine origin (2008) J. Gen. Virol., 89, pp. 2630-2635; (2019) Ministry of Agriculture Forestry and Fisheries Standards of Rearing Hygiene Management, , http://www.maff.go.jp/j/syouan/douei/katiku_yobo/k_shiyou/index.html; The certification standard for “hazard analysis critical control point (HACCP) at livestock farm level: The Farm HACCP Standard Ministry of Agriculture Forestry and Fisheries, , http://www.maff.go.jp/j/syouan/douei/katiku_yobo/k_haccp/index.html, accessed on December 25, 2019; Pastoret, P., Schwers, A., Vanden Broecke, C., Werenne, J., Epizootiology of rotavirus diarrhoea in the bovine species (1984) Rev. Sci. Tech., 3, pp. 843-853; Smits, S.L., Lavazza, A., Matiz, K., Horzinek, M.C., Koopmans, M.P., de Groot, R.J., Phylogenetic and evolutionary relationships among torovirus field variants: Evidence for multiple intertypic recombination events (2003) J. Virol., 77, pp. 9567-9577; Tsunemitsu, H., Smith, D.R., Saif, L.J., Experimental inoculation of adult dairy cows with bovine coronavirus and detection of coronavirus in feces by RT-PCR (1999) Arch. Virol., 144, pp. 167-175; (2007), https://www.aphis.usda.gov/animal_health/nahms/beefcowcalf/downloads/beef0708/Beef0708_dr_PartII.pdf, accessed on December 25, 2019","Takehara, K.; Laboratory of Animal Health, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8, Saiwai-cho, Fuchu-shi, Japan; email: takehara@cc.tuat.ac.jp",,Japanese Society of Veterinary Science,9167250,,,31941845,English,J. Vet. Med. Sci.,Article,Final,Open Access,Scopus,2-s2.0-85080985890,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhang M., Li W., Zhou P., Liu D., Luo R., Jongkaewwattana A., He Q.",56861436900;57212515918;57210556175;57194052433;35230419100;25824320100;7402117843;,Genetic manipulation of porcine deltacoronavirus reveals insights into NS6 and NS7 functions: a novel strategy for vaccine design,2020,Emerging Microbes and Infections,9,1,,20,31,,,10.1080/22221751.2019.1701391,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85076885089&doi=10.1080%2f22221751.2019.1701391&partnerID=40&md5=dfb2afb4016aac91b76bcfebb7e22fcd,"State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, the Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China; Virology and Cell Technology Laboratory, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani, Thailand","Zhang, M., State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, the Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China; Li, W., State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, the Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China; Zhou, P., State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, the Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China; Liu, D., State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, the Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China; Luo, R., State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, the Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China; Jongkaewwattana, A., Virology and Cell Technology Laboratory, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani, Thailand; He, Q., State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, the Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China","Porcine deltacoronavirus (PDCoV) is an emerging swine coronavirus that causes severe diarrhea, resulting in high mortality in neonatal piglets. Despite widespread outbreaks in many countries, no effective PDCoV vaccines are currently available. Here, we generated, for the first time, a full-length infectious cDNA clone of PDCoV. We further manipulated the infectious clone by replacing the NS6 gene with a green fluorescent protein (GFP) to generate rPDCoV-ΔNS6-GFP; likewise, rPDCoV-ΔNS7 was constructed by removing the ATG start codons of the NS7 gene. Growth kinetics studies suggest that rPDCoV-ΔNS7 could replicate similarly to that of the wild-type PDCoV, whereas rPDCoV-ΔNS6-GFP exhibited a substantial reduction of viral titer in vitro and in vivo. Piglets inoculated with rPDCoV-ΔNS7 or wild-type PDCoV showed similar diarrheic scores and pathological injury. In contrast, rPDCoV-ΔNS6-GFP-infected piglets did not show any clinical signs, indicating that the NS6 protein is an important virulence factor of PDCoV and that the NS6-deficient mutant virus might be a promising live-attenuated vaccine candidate. Taken together, the reverse genetics platform described here not only provides more insights into the role of PDCoV accessory proteins in viral replication and pathogenesis, but also allows the development of novel vaccines against PDCoV infection. © 2019, © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd.",accessory protein; infectous clone; pathogenesis; PDCoV; vaccine,"interleukin 1beta; interleukin 6; live vaccine; messenger RNA; tumor necrosis factor; virulence factor; complementary DNA; cytokine; viral protein; virus vaccine; animal experiment; animal tissue; antigen detection; Article; clone; controlled study; Coronavirinae; cytokine production; drug design; genetic manipulation; in vitro study; in vivo study; infectious diarrhea; molecular cloning; mRNA expression level; nonhuman; piglet; porcine deltacoronavirus; priority journal; reverse genetics; scoring system; virogenesis; virus gene; virus load; virus mutant; virus pathogenesis; virus recombinant; virus replication; virus virulence; animal; classification; communicable disease; Coronavirinae; Coronavirus infection; genetics; immunology; newborn; pathology; physiology; pig; swine disease; veterinary medicine; virology; virus genome; virus shedding; Animals; Animals, Newborn; Communicable Diseases, Emerging; Coronavirus; Coronavirus Infections; Cytokines; DNA, Complementary; Genome, Viral; Reverse Genetics; Sus scrofa; Swine; Swine Diseases; Viral Regulatory and Accessory Proteins; Viral Vaccines; Virus Replication; Virus Shedding","Fehr, A.R., Perlman, S., Coronaviruses: an overview of their replication and pathogenesis (2015) Methods Mol Biol, 1282, pp. 1-23; Woo, P.C.Y., Lau, S.K.P., Lam, C.S.F., Discovery of seven novel Mammalian and avian coronaviruses in the genus deltacoronavirus supports bat coronaviruses as the gene source of alphacoronavirus and betacoronavirus and avian coronaviruses as the gene source of gammacoronavirus and deltacoronavirus (2012) J Virol, 86, pp. 3995-4008; Li, G., Chen, Q., Harmon, K.M., Full-length genome sequence of porcine deltacoronavirus strain USA/IA/2014/8734 (2014) Genome Announc, 2, pp. e00278-e214; Janetanakit, T., Lumyai, M., Bunpapong, N., Porcine deltacoronavirus, Thailand, 2015 (2016) Emerging Infect Dis, 22, pp. 757-759; Zhang, M.-J., Liu, D.-J., Liu, X.-L., Genomic characterization and pathogenicity of porcine deltacoronavirus strain CHN-HG-2017 from China (2019) Arch Virol, 164 (2), pp. 413-425; Song, D., Zhou, X., Peng, Q., Newly emerged porcine deltacoronavirus associated with diarrhoea in swine in China: identification, prevalence and full-length genome sequence analysis (2015) Transbound Emerg Dis, 62, pp. 575-580; Wang, L., Byrum, B., Zhang, Y., Detection and genetic characterization of deltacoronavirus in pigs, Ohio, USA, 2014 (2014) Emerging Infect Dis, 20, pp. 1227-1230; Marthaler, D., Jiang, Y., Collins, J., Complete genome sequence of strain SDCV/USA/Illinois121/2014, a porcine deltacoronavirus from the United States (2014) Genome Announc, 2, pp. e00218-e214; Marthaler, D., Raymond, L., Jiang, Y., Rapid detection, complete genome sequencing, and phylogenetic analysis of porcine deltacoronavirus (2014) Emerging Infect Dis., 20, pp. 1347-1350; Wang, L., Byrum, B., Zhang, Y., Porcine coronavirus HKU15 detected in 9 US states, 2014 (2014) Emerging Infect Dis., 20, pp. 1594-1595; Wang, L., Zhang, Y., Byrum, B., Complete genome sequence of porcine coronavirus HKU15 strain IN2847 from the United States (2014) Genome Announc, 2, pp. e00291-e214; Lee, S., Lee, C., Complete genome characterization of Korean Porcine deltacoronavirus strain KOR/KNU14-04/2014 (2014) Genome Announc, 2, pp. e01191-e1114; Chen, F., Zhu, Y., Wu, M., Full-Length genome characterization of Chinese porcine deltacoronavirus strain CH/SXD1/2015 (2015) Genome Announc, 3, pp. e01284-e1215; Zhai, S.-L., Wei, W.-K., Li, X.-P., Occurrence and sequence analysis of porcine deltacoronaviruses in southern China (2016) Virol J, 13, p. 136; Woo, P.C.Y., Lau, S.K.P., Lam, C.S.F., Comparative analysis of complete genome sequences of three avian coronaviruses reveals a novel group 3c coronavirus (2009) J Virol, 83, pp. 908-917; Brierley, I., Digard, P., Inglis, S.C., Characterization of an efficient coronavirus ribosomal frameshifting signal: Requirement for an RNA pseudoknot (1989) Cell, 57, pp. 537-547; de Haan, C.A.M., Masters, P.S., Shen, X., The group-specific murine coronavirus genes are not essential, but their deletion, by reverse genetics, is Attenuating in the natural host (2002) Virology, 296, pp. 177-189; Dijkman, R., Jebbink, M.F., Wilbrink, B., Human coronavirus 229E encodes a single ORF4 protein between the spike and the envelope genes (2006) Virol J, 3, p. 106; Duarte, M., Tobler, K., Bridgen, A., Sequence analysis of the porcine epidemic diarrhea virus genome between the nucleocapsid and spike protein genes reveals a polymorphic ORF (1994) Virology, 198, pp. 466-476; Eleouet, J.-F., Rasschaert, D., Lambert, P., Complete sequence (20 Kilobases) of the polyprotein-encoding gene 1 of transmissible gastroenteritis virus (1995) Virology, 206, pp. 817-822; Masters, P.S., The molecular biology of coronaviruses (2006) Adv Virus Res, 66, pp. 193-292; Liu, D.X., Fung, T.S., Chong, K.K.-L., Accessory proteins of SARS-CoV and other coronaviruses (2014) Antiviral Res, 109, pp. 97-109; Cavanagh, D., Coronavirus avian infectious bronchitis virus (2007) Vet Res, 38, pp. 281-297; Yount, B., Roberts, R.S., Sims, A.C., Severe acute respiratory syndrome coronavirus group-specific open reading frames encode nonessential functions for replication in cell cultures and mice (2005) J Virol, 79, pp. 14909-14922; Tan, Y.-J., Lim, S.G., Hong, W., Understanding the accessory viral proteins unique to the severe acute respiratory syndrome (SARS) coronavirus (2006) Antiviral Res, 72, pp. 78-88; Fischer, F., Peng, D., Hingley, S.T., The internal open reading frame within the nucleocapsid gene of mouse hepatitis virus encodes a structural protein that is not essential for viral replication (1997) J Virol., 71, pp. 996-1003; Beall, A., Yount, B., Lin, C.-M., Characterization of a pathogenic full-length cDNA clone and transmission model for porcine epidemic diarrhea virus strain PC22A (2016) mBio, 7, pp. e01451-e1415; Haijema, B.J., Volders, H., Rottier, P.J.M., Live, attenuated coronavirus vaccines through the directed deletion of group-specific genes provide protection against feline infectious peritonitis (2004) J Virol, 78, pp. 3863-3871; Fang, P., Fang, L., Liu, X., Identification and subcellular localization of porcine deltacoronavirus accessory protein NS6 (2016) Virology, 499, pp. 170-177; Fang, P., Fang, L., Hong, Y., Discovery of a novel accessory protein NS7a encoded by porcine deltacoronavirus (2017) J Gen Virol., 98, pp. 173-178; Yount, B., Curtis, K.M., Fritz, E.A., Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus (2003) Proc Natl Acad Sci U S A, 100, pp. 12995-13000; Scobey, T., Yount, B.L., Sims, A.C., Reverse genetics with a full-length infectious cDNA of the Middle East respiratory syndrome coronavirus (2013) Proc Natl Acad Sci U S A, 110, pp. 16157-16162; Donaldson, E.F., Yount, B., Sims, A.C., Systematic assembly of a full-length infectious clone of human coronavirus NL63 (2008) J Virol, 82, pp. 11948-11957; Yount, B., Curtis, K.M., Baric, R.S., Strategy for systematic assembly of large RNA and DNA genomes: transmissible gastroenteritis virus model (2000) J Virol, 74, pp. 10600-10611; Yount, B., Denison, M.R., Weiss, S.R., Systematic assembly of a full-length infectious cDNA of mouse hepatitis virus strain A59 (2002) J Virol, 76, pp. 11065-11078; Youn, S., Leibowitz, J., Collisson, E.W., In vitro assembled, recombinant infectious bronchitis viruses demonstrate that the 5a open reading frame is not essential for replication (2005) Virology, 332, pp. 206-215; Lee, S., Lee, C., Functional characterization and proteomic analysis of the nucleocapsid protein of porcine deltacoronavirus (2015) Virus Res, 208, pp. 136-145; Menachery, V.D., Mitchell, H.D., Cockrell, A.S., MERS-CoV accessory ORFs play key role for infection and pathogenesis (2017) mBio, 8, pp. e00665-e617; Cruz, J.L.G., Sola, I., Becares, M., Coronavirus gene 7 counteracts host defenses and modulates virus virulence (2011) PLoS Pathog, 7, p. e1002090; Fang, P., Fang, L., Ren, J., Porcine deltacoronavirus accessory protein NS6 antagonizes interferon beta production by interfering with the binding of RIG-I/MDA5 to double-stranded RNA (2018) J Virol, 92, pp. e00712-e718; Hu, H., Jung, K., Vlasova, A.N., Isolation and characterization of porcine deltacoronavirus from pigs with diarrhea in the United States (2015) J Clin Microbiol, 53, pp. 1537-1548","He, Q.; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural UniversityChina; email: he628@mail.hzau.edu.cn",,Taylor and Francis Ltd.,22221751,,,31859605,English,Emerg. Microbes Infect.,Article,Final,Open Access,Scopus,2-s2.0-85076885089,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Jones R.M., Bleasdale S.C., Maita D., Brosseau L.M., CDC Prevention Epicenters Program",7501542928;22950113800;57209800994;7004360938;,A systematic risk-based strategy to select personal protective equipment for infectious diseases,2020,American Journal of Infection Control,48,1,,46,51,,,10.1016/j.ajic.2019.06.023,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85069631248&doi=10.1016%2fj.ajic.2019.06.023&partnerID=40&md5=b607bec285c5dad033c36a7dae03ade4,"School of Public Health, Division of Environmental and Occupational Health Sciences, University of Illinois at Chicago, Chicago, IL, United States; College of Medicine, Department of Medicine, University of Illinois at Chicago, Chicago, IL, United States; School of Medicine, Department of Family and Preventive Medicine, University of Utah, Salt Lake City, UT, United States","Jones, R.M., School of Public Health, Division of Environmental and Occupational Health Sciences, University of Illinois at Chicago, Chicago, IL, United States, School of Medicine, Department of Family and Preventive Medicine, University of Utah, Salt Lake City, UT, United States; Bleasdale, S.C., College of Medicine, Department of Medicine, University of Illinois at Chicago, Chicago, IL, United States; Maita, D., College of Medicine, Department of Medicine, University of Illinois at Chicago, Chicago, IL, United States; Brosseau, L.M., School of Public Health, Division of Environmental and Occupational Health Sciences, University of Illinois at Chicago, Chicago, IL, United States; CDC Prevention Epicenters Program","Background: Personal protective equipment (PPE) is a primary strategy to protect health care personnel (HCP) from infectious diseases. When transmission-based PPE ensembles are not appropriate, HCP must recognize the transmission pathway of the disease and anticipate the exposures to select PPE. Because guidance for this process is extremely limited, we proposed a systematic, risk-based approach to the selection and evaluation of PPE ensembles to protect HCP against infectious diseases. Methods: The approach used in this study included the following 4 steps: (1) job hazard analysis, (2) infectious disease hazard analysis, (3) selection of PPE, and (4) evaluation of selected PPE. Selected PPE should protect HCP from exposure, be usable by HCP, and fit for purpose. Results: The approach was demonstrated for the activity of intubation of a patient with methicillin-resistant Staphylococcus aureus or Severe Acute Respiratory Syndrome coronavirus. As expected, the approach led to the selection of different ensembles of PPE for these 2 pathogens. Discussion: A systematic risk-based approach to the selection of PPE will help health care facilities and HCP select PPE when transmission-based precautions are not appropriate. Owing to the complexity of PPE ensemble selection and evaluation, a team with expertise in infectious diseases, occupational health, the health care activity, and related disciplines, such as human factors, should be engaged. Conclusions: Participation, documentation, and transparency are necessary to ensure the decisions can be communicated, critiqued, and understood by HCP. © 2019 Association for Professionals in Infection Control and Epidemiology, Inc.",Exposure; High-consequence infections; Industrial hygiene; Infection prevention; Intubation; Job hazard analysis,Article; hazard assessment; health care facility; health care personnel; human; infection; infection prevention; methicillin resistant Staphylococcus aureus; nonhuman; occupational hazard; occupational health; risk; SARS coronavirus,"Siegel, J.D., Rhinehart, E., Jackson, M., Chiarello, L., 2007 guideline for isolation precautions: preventing transmission of infectious agents in healthcare ettings (2007) Am J Infect Control, 35, pp. 65-164; Centers for Disease Control and Prevention, (2018), https://www.cdc.gov/infectioncontrol/basics/standard-precautions.html, Standard precautions for all patient care. Available from: Accessed April 17; Gammon, J., Morgan-Samuel, H., Gould, D., A review of the evidence for suboptimal compliance of healthcare practitioners to standard/universal infection control precautions (2008) J Clin Nurs, 17, pp. 157-167; Kinlay, J., Flaherty, K., Scanlon, P., Mehrotra, P., Potter-Bynoe, G., Sandora, T.J., Barriers to the use of face protection for standard precautions by health care providers (2015) Am J Infect Control, 43, pp. 169-170; Bleasdale, S.C., Sikka, M., Brosseau, L.M., Fritzen-Pedicini, C., Moritz, D., Stiehl, E., Experience of Chicagoland acute care hospitals preparing for Ebola Virus Disease, 2014-2015 (2019) J Occup Environ Hyg, 16, pp. 582-591; (2018), https://www.cdc.gov/ppeinfo, National Institute for Occupational Safety and Health. NIOSH personal protective equipment information (PPE-Info). Available from: Accessed August 17; Gudgin Dickson, E., Personal protective equipment for chemical, biological and radiological hazards: design, evaluation, and selection (2013), John Wiley & Sons; Hoboken (NJ); Occupational Safety and 4 Administration, (2018), https://www.osha.gov/dsg/id/tab6.pdf, OSHA's infectious diseases regulatory framework. Available from: Accessed August 17; Roughton, J., Crutchfield, N., Job hazard analysis: a guide for voluntary compliance and beyond (2011), Elsevier Science & Technology Burlington (MA); Zartarian, V., Bahadori, T., McKone, T., Adoption of an official ISEA glossary (2005) J Expo Anal Environ Epidemiol, 15, pp. 1-5; Chosewood, C.L., Wilson, D.E., Biosafety in microbiological and biomedical laboratories (2009), US Department of Health and Human Services Atlanta (GA); Jones, R.M., Brosseau, L.M., Aerosol transmission of infectious disease (2015) J Occup Environ Med, 57, pp. 501-508; Roy, C.J., Milton, D.K., Airborne transmission of communicable infection - the elusive pathway (2004) N Engl J Med, 17, pp. 1710-1712; Herlihey, T.A., Gelmi, S., Fewwelling, C.J., Hall, T.N., Banez, C., Moirta, P.P., Personal protective equipment for infectious disease preparedness: a human factors evaluation (2016) Infect Control Hosp Epidemiol, 37, pp. 1022-1028; International Safety Equipment Association, (2017), https://safetyequipment.org/wp-content/uploads/2015/05/ISEA-EF-2016-Selection-and-Use-1.pdf, Eye and face protection selection tool. Available from: Accessed August 9; Centers for Disease Control and Prevention, (2017), https://www.cdc.gov/vhf/ebola/healthcare-us/ppe/guidance.html, Guidance on personal protective equipment (PPE) to be used by healthcare workers during management of patients with confirmed Ebola or Persons under Investigation (PUIs) for Ebola who are clinically unstable or have bleeding, vomiting or diarrhea in U.S. Hospitals, including procedures for donning and doffing PPE. 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J. Infect. Control,Article,Final,Open Access,Scopus,2-s2.0-85069631248,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wang X., Li F., Han M., Jia S., Wang L., Qiao X., Jiang Y., Cui W., Tang L., Li Y., Xu Y.-G.",57211221047;57212466170;57212374542;57193093859;57193361612;35330912300;56003035300;57208296572;36169591400;56178878700;34772167800;,"Cloning, prokaryotic soluble expression, and analysis of antiviral activity of two novel feline IFN-ω proteins",2020,Viruses,12,3,335,,,,,10.3390/v12030335,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082250129&doi=10.3390%2fv12030335&partnerID=40&md5=5d826ef8afb85ffa539578fc87d0ba55,"Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China; Northeastern Science Inspection Station, China Ministry of Agriculture Key Laboratory of Animal Pathogen Biology, Harbin, 150030, China","Wang, X., Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China; Li, F., Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China; Han, M., Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China; Jia, S., Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China; Wang, L., Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China; Qiao, X., Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China; Jiang, Y., Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China; Cui, W., Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China; Tang, L., Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China, Northeastern Science Inspection Station, China Ministry of Agriculture Key Laboratory of Animal Pathogen Biology, Harbin, 150030, China; Li, Y., Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China, Northeastern Science Inspection Station, China Ministry of Agriculture Key Laboratory of Animal Pathogen Biology, Harbin, 150030, China; Xu, Y.-G., Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, College of Veterinary Medicine, Northeast Agricultural University, Harbin, 150030, China, Northeastern Science Inspection Station, China Ministry of Agriculture Key Laboratory of Animal Pathogen Biology, Harbin, 150030, China","Cats are becoming more popular as household companions and pets, forming close relationships with humans. Although feline viral diseases can pose serious health hazards to pet cats, commercialized preventative vaccines are lacking. Interferons (IFNs), especially type I IFNs (IFN-α, IFN-β, and interferon omega (IFN-ω)), have been explored as effective therapeutic drugs against viral diseases in cats. Nevertheless, there is limited knowledge regarding feline IFN-ω (feIFN-ω), compared to IFN-ct and IFN-β. In this study, we cloned the genes encoding feIFN-ωa and feIFN-ωb from cat spleen lymphocytes. Homology and phylogenetic tree analysis revealed that these two genes belonged to new subtypes of feIFN-ω. The recombinant feIFN-ωa and feIFN-ωb proteins were expressed in their soluble forms in Escherichia coli, followed by purification. Both proteins exhibited effective anti-vesicular stomatitis virus (VSV) activity in Vero, F81 (feline kidney cell), Madin-Darby bovine kidney (MDBK), Madin-Darby canine kidney (MDCK), and porcine kidney (PK-15) cells, showing broader cross-species antiviral activity than the INTERCAT IFN antiviral drug. Furthermore, the recombinant feIFN-ωa and feIFN-ωb proteins demonstrated antiviral activity against VSV, feline coronavirus (FCoV), canine parvovirus (CPV), bovine viral diarrhea virus (BVDV), and porcine epidemic diarrhea virus (PEDV), indicating better broad-spectrum antiviral activity than the INTERCAT IFN. The two novel feIFN-ω proteins (feIFN-ωa and feIFN-ωb) described in this study show promising potential to serve as effective therapeutic agents for treating viral infections in pet cats. © 2020 by the authors. 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Hepatol., 21, pp. 1538-1543","Xu, Y.-G.; Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, College of Veterinary Medicine, Northeast Agricultural UniversityChina; email: yigangxu@neau.edu.cn",,MDPI AG,19994915,,,32204464,English,Viruses,Article,Final,Open Access,Scopus,2-s2.0-85082250129,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Sanchez C.M., Pascual-Iglesias A., Sola I., Zuñiga S., Enjuanes L.",57193985365;57189495794;7003336781;6603777678;7006565392;,Minimum determinants of transmissible gastroenteritis virus enteric tropism are located in the n-terminus of spike protein,2020,Pathogens,9,1,2,,,,,10.3390/pathogens9010002,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077195869&doi=10.3390%2fpathogens9010002&partnerID=40&md5=160c3550259adc0d37921489fcf0149c,"Department of Molecular and Cell Biology, National Center of Biotechnology (CNB-CSIC), Campus Universidad Autónoma de Madrid, Darwin 3, Madrid, 28049, Spain","Sanchez, C.M., Department of Molecular and Cell Biology, National Center of Biotechnology (CNB-CSIC), Campus Universidad Autónoma de Madrid, Darwin 3, Madrid, 28049, Spain; Pascual-Iglesias, A., Department of Molecular and Cell Biology, National Center of Biotechnology (CNB-CSIC), Campus Universidad Autónoma de Madrid, Darwin 3, Madrid, 28049, Spain; Sola, I., Department of Molecular and Cell Biology, National Center of Biotechnology (CNB-CSIC), Campus Universidad Autónoma de Madrid, Darwin 3, Madrid, 28049, Spain; Zuñiga, S., Department of Molecular and Cell Biology, National Center of Biotechnology (CNB-CSIC), Campus Universidad Autónoma de Madrid, Darwin 3, Madrid, 28049, Spain; Enjuanes, L., Department of Molecular and Cell Biology, National Center of Biotechnology (CNB-CSIC), Campus Universidad Autónoma de Madrid, Darwin 3, Madrid, 28049, Spain","Transmissible gastroenteritis virus (TGEV) is an enteric coronavirus causing high morbidity and mortality in porcine herds worldwide, that possesses both enteric and respiratory tropism. The ability to replicate in the enteric tract directly correlates with virulence, as TGEVs with an exclusive respiratory tropism are attenuated. The tissue tropism is determined by spike (S) protein, although the molecular bases for enteric tropism remain to be fully characterized. Both pAPN and sialic acid binding domains (aa 506–655 and 145–155, respectively) are necessary but not sufficient for enteric tract infection. Using a TGEV infectious cDNA and enteric (TGEV-SC11) or respiratory (TGEV-SPTV) isolates, encoding a full-length S protein, a set of chimeric recombinant viruses, with a sequential modification in S protein amino terminus, was engineered. In vivo tropism, either enteric, respiratory or both, was studied by inoculating three-day-old piglets and analyzing viral titers in lung and gut. The data indicated that U655>G change in S gene (S219A in S protein) was required to confer enteric tropism to a respiratory virus that already contains the pAPN and sialic acid binding domains in its S protein. Moreover, an engineered virus containing U655>G and a 6 nt insertion at position 1124 (Y374-T375insND in S protein) was genetically stable after passage in cell cultures, and increased virus titers in gut by 1000-fold. We postulated that the effect of these residues in enteric tropism may be mediated by the modification of both glycosaminoglycan binding and S protein structure. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.",Enteric tropism; Recombinant virus; Transmissible gastroenteritis virus; Tropism,chimeric antibody; chimeric protein; complementary DNA; glycosaminoglycan; rs7 protein; sc11 protein; sialic acid; synaptic protein transport vesicle; unclassified drug; virus RNA; virus spike protein; vitronectin; amino acid sequence; amino terminal sequence; animal cell; animal experiment; Article; bacterial artificial chromosome; binding site; cell culture; comparative study; controlled study; enteric virus; gastrointestinal infection; gene mutation; genetic transfection; glycosaminoglycan metabolism; molecular cloning; morbidity; mortality; nonhuman; plasmid; Porcine respiratory coronavirus; protein motif; protein stability; protein structure; respiratory virus; reverse transcription polymerase chain reaction; sequence analysis; Transmissible gastroenteritis virus; viral tropism; virogenesis; virus load; virus recombinant; virus release; virus replication; virus transmission,"Chattha, K.S., Roth, J.A., Saif, L.J., Strategies for design and application of enteric viral vaccines (2015) Annu. Rev. Anim. Biosci., 3, pp. 375-395; Wang, Q., Vlasova, A.N., Kenney, S.P., Saif, L.J., Emerging and re-emerging coronaviruses in pigs (2019) Curr. Opin. Virol., 34, pp. 39-49; de Groot, R.J., Baker, S.C., Baric, R., Enjuanes, L., Gorbalenya, A.E., Holmes, K.V., Perlman, S., Talbot, P.J., Family Coronaviridae. In Virus Taxonomy, Classification and Nomenclature of Viruses. 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Virol., 69, pp. 1725-1730; Pensaert, M., Callebaut, P., Vergote, J., Isolation of a porcine respiratory, non-enteric coronavirus related to transmissible gastroenteritis (1986) Vet. Quart., 8, pp. 257-260; Schwegmann-Wessels, C., Zimmer, G., Laude, H., Enjuanes, L., Herrler, G., Binding of transmissible gastroenteritis coronavirus to cell surface sialoglycoproteins (2002) J. Virol., 76, pp. 6037-6043; Krempl, C., Schultze, B., Laude, H., Herrler, G., Point mutations in the S protein connect the sialic acid binding activity with the enteropathogenicity of transmissible gastroenteritis coronavirus (1997) J. Virol., 71, pp. 3285-3287; Wang, G., Liang, R., Liu, Z., Shen, Z., Shi, J., Shi, Y., Deng, F., Peng, G., The N-Terminal Domain of Spike Protein Is Not the Enteric Tropism Determinant for Transmissible Gastroenteritis Virus in Piglets (2019) Viruses, 11, p. 313; Correa, I., Gebauer, F., Bullido, M.J., Sune, C., Baay, M.F., Zwaagstra, K.A., Posthumus, W.P., Enjuanes, L., Localization of antigenic sites of the E2 glycoprotein of transmissible gastroenteritis coronavirus (1990) J. Gen. Virol., 71, pp. 271-279; Almazan, F., Gonzalez, J.M., Penzes, Z., Izeta, A., Calvo, E., Plana-Duran, J., Enjuanes, L., Engineering the largest RNA virus genome as an infectious bacterial artificial chromosome (2000) Proc. Natl. Acad. Sci. USA, 97, pp. 5516-5521; Ortego, J., Sola, I., Almazan, F., Ceriani, J.E., Riquelme, C., Balasch, M., Plana, J., Enjuanes, L., Transmissible gastroenteritis coronavirus gene 7 is not essential but influences in vivo virus replication and virulence (2003) Virology, 308, pp. 13-22; Sola, I., Alonso, S., Zuñiga, S., Balasch, M., Plana-Duran, J., Enjuanes, L., Engineering the transmissible gastroenteritis virus genome as an expression vector inducing lactogenic immunity (2003) J. Virol., 77, pp. 4357-4369; Becares, M., Sanchez, C.M., Sola, I., Enjuanes, L., Zuñiga, S., Antigenic structures stably expressed by recombinant TGEV-derived vectors (2014) Virology, 464, pp. 274-286; Hu, X., Jr., Li, N., Jr., Tian, Z., Jr., Yin, X., Jr., Qu, L., Qu, J., Molecular characterization and phylogenetic analysis of transmissible gastroenteritis virus HX strain isolated from China (2015) BMC Vet. 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Virol., 71, pp. 5115-5123; Klimstra, W.B., Ryman, K.D., Johnston, R.E., Adaptation of Sindbis virus to BHK cells selects for use of heparan sulfate as an attachment receptor (1998) J. Virol., 72, pp. 7357-7366; Byrnes, A.P., Griffin, D.E., Large-plaque mutants of Sindbis virus show reduced binding to heparan sulfate, heightened viremia, and slower clearance from the circulation (2000) J. Virol., 74, pp. 644-651; Bernard, K.A., Klimstra, W.B., Johnston, R.E., Mutations in the E2 glycoprotein of Venezuelan equine encephalitis virus confer heparan sulfate interaction, low morbidity, and rapid clearance from blood of mice (2000) Virology, 276, pp. 93-103; Lee, E., Hall, R.A., Lobigs, M., Common E protein determinants for attenuation of glycosaminoglycan-binding variants of Japanese encephalitis and West Nile viruses (2004) J. 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Protoc., 7, pp. 1511-1522; Delmas, B., Gelfi, J., Kut, E., Sjostrom, H., Noren, O., Laude, H., Determinants essential for the transmissible gastroenteritis virus-receptor interaction reside within a domain of aminopeptidase-N that is distinct from the enzymatic site (1994) J. Virol., 68, pp. 5216-5224; McClurkin, A.W., Norman, J.O., Studies on transmissible gastroenteritis of swine. II. Selected characteristics of a cytopathogenic virus common to five isolates from transmissible gastroenteritis (1966) Can. J. Comp. Med. Vet. Sci., 30, pp. 190-198; Almazan, F., Galan, C., Enjuanes, L., Engineering infectious cDNAs of coronavirus as bacterial artificial chromosomes (2008) Methods Mol. Biol., 454, pp. 275-291; Jimenez, G., Correa, I., Melgosa, M.P., Bullido, M.J., Enjuanes, L., Critical epitopes in transmissible gastroenteritis virus neutralization (1986) J. Virol., 60, pp. 131-139; Gouw, M., Michael, S., Samano-Sanchez, H., Kumar, M., Zeke, A., Lang, B., Bely, B., Deng, Z., The eukaryotic linear motif resource-2018 update (2018) Nucleic Acids Res, 46, pp. D428–D434; Pettersen, E.F., Goddard, T.D., Huang, C.C., Couch, G.S., Greenblatt, D.M., Meng, E.C., Ferrin, T.E., UCSF Chimera—A visualization system for exploratory research and analysis (2004) J. Comput. Chem., 25, pp. 1605-1612","Zuñiga, S.; Department of Molecular and Cell Biology, National Center of Biotechnology (CNB-CSIC), Campus Universidad Autónoma de Madrid, Darwin 3, Spain; email: szuniga@cnb.csic.es",,MDPI AG,20760817,,,,English,Pathogens,Article,Final,Open Access,Scopus,2-s2.0-85077195869,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Niu J., Shen L., Huang B., Ye F., Zhao L., Wang H., Deng Y., Tan W.",57209102341;57199824189;35082078200;56992108600;57211780167;37008111500;36238838100;7401959748;,Non-invasive bioluminescence imaging of HCoV-OC43 infection and therapy in the central nervous system of live mice,2020,Antiviral Research,173,,104646,,,,1,10.1016/j.antiviral.2019.104646,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85074916237&doi=10.1016%2fj.antiviral.2019.104646&partnerID=40&md5=8c1321d1e50b43ee23226baeac8c1604,"Key Laboratory of Biosafety, National Health Commissions, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, 102206, China; Department of Clinical Laboratory, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei Province 441021, China; Key Laboratory of Molecular Medicine, Medical College, Hubei University of Arts and Science, Xiangyang, 441053, China; Center for Biosafety Mega-Science, Chinese Academy of Sciences, China","Niu, J., Key Laboratory of Biosafety, National Health Commissions, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, 102206, China; Shen, L., Department of Clinical Laboratory, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei Province 441021, China, Key Laboratory of Molecular Medicine, Medical College, Hubei University of Arts and Science, Xiangyang, 441053, China; Huang, B., Key Laboratory of Biosafety, National Health Commissions, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, 102206, China; Ye, F., Key Laboratory of Biosafety, National Health Commissions, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, 102206, China; Zhao, L., Key Laboratory of Biosafety, National Health Commissions, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, 102206, China; Wang, H., Key Laboratory of Biosafety, National Health Commissions, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, 102206, China; Deng, Y., Key Laboratory of Biosafety, National Health Commissions, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, 102206, China; Tan, W., Key Laboratory of Biosafety, National Health Commissions, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, 102206, China, Center for Biosafety Mega-Science, Chinese Academy of Sciences, China","Human coronaviruses (HCoVs) are important pathogens that cause upper respiratory tract infections and have neuroinvasive abilities; however, little is known about the dynamic infection process of CoVs in vivo, and there are currently no specific antiviral drugs to prevent or treat HCoV infection. Here, we verified the replication ability and pathogenicity of a reporter HCoV-OC43 strain expressing Renilla luciferase (Rluc; rOC43-ns2DelRluc) in mice with different genetic backgrounds (C57BL/6 and BALB/c). Additionally, we monitored the spatial and temporal progression of HCoV-OC43 through the central nervous system (CNS) of live BALB/c mice after intranasal or intracerebral inoculation with rOC43-ns2DelRluc. We found that rOC43-ns2DelRluc was fatal to suckling mice after intranasal inoculation, and that viral titers and Rluc expression were detected in the brains and spinal cords of mice infected with rOC43-ns2DelRluc. Moreover, viral replication was initially observed in the brain by non-invasive bioluminescence imaging before the infection spread to the spinal cord of BALB/c mice, consistent with its tropism in the CNS. Furthermore, the Rluc readout correlated with the HCoV replication ability and protein expression, which allowed quantification of antiviral activity in live mice. Additionally, we validated that chloroquine strongly inhibited rOC43-ns2DelRluc replication in vivo. These results provide new insights into the temporal and spatial dissemination of HCoV-OC43 in the CNS, and our methods provide an extremely sensitive platform for evaluating the efficacy of antiviral therapies to treat neuroinvasive HCoVs in live mice. © 2019 Elsevier B.V.",Bioluminescence imaging; Chloroquine; Coronavirus; Mouse; Therapy,Renilla luciferin 2 monooxygenase; animal cell; animal experiment; animal model; animal tissue; Article; BHK-21 cell line; bioluminescence; brain; central nervous system; Coronaviridae infection; in vivo study; mouse; nonhuman; priority journal; protein expression; spinal cord; tropism; virus replication; virus strain; virus virulence,"Adams, M.J., Lefkowitz, E.J., King, A.M., Harrach, B., Harrison, R.L., Knowles, N.J., Kropinski, A.M., Davison, A.J., Ratification vote on taxonomic proposals to the international committee on taxonomy of viruses (2016) (2016) Arch. 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Imaging Biol., 9, pp. 267-277; Wilde De, A.H., Dirk, J., Posthuma, C.C., Zevenhoven-Dobbe, J.C., Stefan, V.N., Bestebroer, T.M., Hoogen Van Den, B.G., Snijder, E.J., Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture (2014) Antimicrob. Agents Chemother., 58, p. 4875; Woo, P.C., Huang, Y., Lau, S.K., Yuen, K.Y., Coronavirus genomics and bioinformatics analysis (2010) Viruses, 2, pp. 1804-1820; Woo, P.C., Lau, S.K., Chu, C.M., Chan, K.H., Tsoi, H.W., Huang, Y., Wong, B.H., Yuen, K.Y., Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia (2005) J. Virol., 79, pp. 884-895; Woo, P.C., Lau, S.K., Tsoi, H.W., Huang, Y., Poon, R.W., Chu, C.M., Lee, R.A., Yuen, K.Y., Clinical and molecular epidemiological features of coronavirus HKU1-associated community-acquired pneumonia (2005) J. Infect. Dis., 192, pp. 1898-1907; Yiwu, Y., Zhen, Z., Yang, S., Xiao, L., Kai-Feng, X., Yuquan, W., Ningyi, J., Chengyu, J., Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model (2013) Cell Res., 23, pp. 300-302; Yu, J.E., Kim, M., Lee, J.H., Chang, B.J., Song, C.S., Nahm, S.S., Neonatal influenza infection causes pathological changes in the mouse brain (2014) Vet. Res., 45, p. 63","Tan, W.; MHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, China CDC, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 155 Changbai Road, ChangPing District, China; email: tanwj28@163.com",,Elsevier B.V.,1663542,,ARSRD,31705922,English,Antiviral Res.,Article,Final,Open Access,Scopus,2-s2.0-85074916237,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Remuzzi A., Remuzzi G.",7006098570;56466188600;,COVID-19 and Italy: what next?,2020,The Lancet,,,,,,,4,10.1016/S0140-6736(20)30627-9,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081930346&doi=10.1016%2fS0140-6736%2820%2930627-9&partnerID=40&md5=302879ad9b9f7550926c329a71dbdc0e,"Department of Management Information and Production Engineering, University of Bergamo, Dalmine, Italy; Istituto di Ricerche Farmacologiche Mario Negri IRCCS","Remuzzi, A., Department of Management Information and Production Engineering, University of Bergamo, Dalmine, Italy; Remuzzi, G., Istituto di Ricerche Farmacologiche Mario Negri IRCCS","The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has already taken on pandemic proportions, affecting over 100 countries in a matter of weeks. A global response to prepare health systems worldwide is imperative. Although containment measures in China have reduced new cases by more than 90%, this reduction is not the case elsewhere, and Italy has been particularly affected. There is now grave concern regarding the Italian national health system's capacity to effectively respond to the needs of patients who are infected and require intensive care for SARS-CoV-2 pneumonia. The percentage of patients in intensive care reported daily in Italy between March 1 and March 11, 2020, has consistently been between 9% and 11% of patients who are actively infected. The number of patients infected since Feb 21 in Italy closely follows an exponential trend. If this trend continues for 1 more week, there will be 30 000 infected patients. Intensive care units will then be at maximum capacity; up to 4000 hospital beds will be needed by mid-April, 2020. Our analysis might help political leaders and health authorities to allocate enough resources, including personnel, beds, and intensive care facilities, to manage the situation in the next few days and weeks. If the Italian outbreak follows a similar trend as in Hubei province, China, the number of newly infected patients could start to decrease within 3–4 days, departing from the exponential trend. However, this cannot currently be predicted because of differences between social distancing measures and the capacity to quickly build dedicated facilities in China. © 2020 Elsevier Ltd",,,"Callaway, E., Time to use the p-word? Coronavirus enter dangerous new phase (2020) Nature, 579, p. 12; Tourism flows and death rates suggest covid-19 is being under-reported (2020), https://www.economist.com/graphic-detail/2020/03/07/tourism-flows-and-death-rates-suggest-covid-19-is-being-under-reported, (Accessed 11 March 2020); Leung, G., Wuhttps, J., Real-time nowcast and forecast on the extent of the Wuhan CoV outbreak, domestic and international spread (2020), https://www.med.hku.hk/f/news/3549/7418/Wuhan-coronavirus-outbreak_AN-UPDATE_20200127.pdf, (Accessed 11 March 2020); Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med, , published online Jan 29; Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19) (2020), https://www.who.int/docs/default-source/coronaviruse/who-china-joint-mission-on-covid-19-final-report.pdf, (Accessed 11 March 2020); Coronavirus COVID-19 Global Cases (2020), https://systems.jhu.edu/research/public-health/ncov/, (Accessed 11 March 2020)","Remuzzi, A.; Department of Management Information and Production Engineering, University of BergamoItaly; email: andrea.remuzzi@unibg.it",,Lancet Publishing Group,1406736,,LANCA,,English,Lancet,Review,Article in Press,Open Access,Scopus,2-s2.0-85081930346,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Xia W., Shao J., Guo Y., Peng X., Li Z., Hu D.",57215666063;57215831490;57215661869;57215662944;57206873830;7402585026;,Clinical and CT features in pediatric patients with COVID-19 infection: Different points from adults,2020,Pediatric Pulmonology,,,,,,,1,10.1002/ppul.24718,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081635230&doi=10.1002%2fppul.24718&partnerID=40&md5=9d64c66128cbc9aea55906656beb099d,"Department of Imaging Center, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China","Xia, W., Department of Imaging Center, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Shao, J., Department of Imaging Center, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Guo, Y., Department of Imaging Center, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Peng, X., Department of Imaging Center, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Li, Z., Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Hu, D., Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China","Purpose: To discuss the different characteristics of clinical, laboratory, and chest computed tomography (CT) in pediatric patients from adults with 2019 novel coronavirus (COVID-19) infection. Methods: The clinical, laboratory, and chest CT features of 20 pediatric inpatients with COVID-19 infection confirmed by pharyngeal swab COVID-19 nucleic acid test were retrospectively analyzed during 23 January and 8 February 2020. The clinical and laboratory information was obtained from inpatient records. All the patients were undergone chest CT in our hospital. Results: Thirteen pediatric patients (13/20, 65%) had an identified history of close contact with COVID-19 diagnosed family members. Fever (12/20, 60%) and cough (13/20, 65%) were the most common symptoms. For laboratory findings, procalcitonin elevation (16/20, 80%) should be pay attention to, which is not common in adults. Coinfection (8/20, 40%) is common in pediatric patients. A total of 6 patients presented with unilateral pulmonary lesions (6/20, 30%), 10 with bilateral pulmonary lesions (10/20, 50%), and 4 cases showed no abnormality on chest CT (4/20, 20%). Consolidation with surrounding halo sign was observed in 10 patients (10/20, 50%), ground-glass opacities were observed in 12 patients (12/20, 60%), fine mesh shadow was observed in 4 patients (4/20, 20%), and tiny nodules were observed in 3 patients (3/20, 15%). Conclusion: Procalcitonin elevation and consolidation with surrounding halo signs were common in pediatric patients which were different from adults. It is suggested that underlying coinfection may be more common in pediatrics, and the consolidation with surrounding halo sign which is considered as a typical sign in pediatric patients. © 2020 Wiley Periodicals, Inc.",child; clinical features; COVID-19; infection; tomography,,"Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506; Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382, pp. 727-733; Pullano, G., Pinotti, F., Valdano, E., Boelle, P.-Y., Poletto, C., Colizza, V., Novel coronavirus (2019-nCoV) early-stage importation risk to Europe, January 2020 (2020) Euro Surveill, 25, p. 2000057; (2020), Diagnosis and Treatment Protocol for 2019-nCoV. 5th ed. Beijing, China: National Health Commission of China; Parry, J., Wuhan: Britons to be evacuated as scientists estimate 44 000 cases of 2019-nCOV in the city (2020) Brit Med J, 368; Riou, J., Althaus, C.L., Pattern of early human-to-human transmission of Wuhan 2019 novel coronavirus (2019-nCoV), December 2019 to January 2020 (2020) Euro Surveill, 25, pp. 7-11; Hui, D.S., Azhar, E.I., Madani, T.A., The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health—the latest 2019 novel coronavirus outbreak in Wuhan, China (2020) Int J Infect Dis, 91, pp. 264-266; Zhu, H., Wang, L., Fang, C., Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia (2020) Transl Pediatr, 9, pp. 51-60; Simon, L., Gauvin, F., Amre, D.K., Saint-Louis, P., Lacroix, J., Serum procalcitonin and C-reactive protein levels as markers of bacterial infection: a systematic review and meta-analysis (2004) Clin Infect Dis, 39, pp. 206-217; Kanne, J.P., Chest CT findings in 2019 novel coronavirus (2019-nCoV) infections from Wuhan, China: key points for the radiologist (2020) Radiology; Song, F., Shi, N., Shan, F., Emerging coronavirus 2019-nCoV pneumonia (2020) Radiology; Virkki, R., Juven, T., Rikalainen, H., Svedstrom, E., Mertsola, J., Ruuskanen, O., Differentiation of bacterial and viral pneumonia in children (2002) Thorax, 57, pp. 438-441","Shao, J.; Department of Imaging Center, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and TechnologyChina; email: xzhuge27@163.com",,John Wiley and Sons Inc.,87556863,,PEPUE,32134205,English,Pediatr. Pulmonol.,Article,Article in Press,Open Access,Scopus,2-s2.0-85081635230,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Hattoufi K., Tligui H., Obtel M., El Ftouh S., Kharbach A., Barkat A.",57215496627;10839473700;51864136400;57201200410;6701664650;25622474300;,Molecular Diagnosis of Pneumonia Using Multiplex Real-Time PCR Assay RespiFinder® SMART 22 FAST in a Group of Moroccan Infants,2020,Advances in Virology,2020,,6212643,,,,,10.1155/2020/6212643,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081037089&doi=10.1155%2f2020%2f6212643&partnerID=40&md5=2662034d40721110fcb423b8bd0b4fa9,"National Reference Center in Neonatology and Nutrition, Children's Hospital, University Hospital Centre IBN SINA, Rabat, Morocco; Research Team on Health and Nutrition of Mother and Child, Faculty of Medicine and Pharmacy, Mohammed v University, Rabat, Morocco; Medical Research Laboratory, Children's Hospital, University Hospital Centre Ibn Sina, Rabat, Morocco; Department of Public Health, Laboratory of Biostatistics, Clinical Research and Epidemiology, Faculty of Medicine and Pharmacy, Mohammed v University, Rabat, Morocco; Gynaecology-Obstetrics and Endocrinology Department, Maternity Souissi, University Hospital Center IBN SINA, University Mohammed v, Rabat, Morocco","Hattoufi, K., National Reference Center in Neonatology and Nutrition, Children's Hospital, University Hospital Centre IBN SINA, Rabat, Morocco, Research Team on Health and Nutrition of Mother and Child, Faculty of Medicine and Pharmacy, Mohammed v University, Rabat, Morocco; Tligui, H., Medical Research Laboratory, Children's Hospital, University Hospital Centre Ibn Sina, Rabat, Morocco; Obtel, M., Department of Public Health, Laboratory of Biostatistics, Clinical Research and Epidemiology, Faculty of Medicine and Pharmacy, Mohammed v University, Rabat, Morocco; El Ftouh, S., Medical Research Laboratory, Children's Hospital, University Hospital Centre Ibn Sina, Rabat, Morocco; Kharbach, A., Research Team on Health and Nutrition of Mother and Child, Faculty of Medicine and Pharmacy, Mohammed v University, Rabat, Morocco, Gynaecology-Obstetrics and Endocrinology Department, Maternity Souissi, University Hospital Center IBN SINA, University Mohammed v, Rabat, Morocco; Barkat, A., National Reference Center in Neonatology and Nutrition, Children's Hospital, University Hospital Centre IBN SINA, Rabat, Morocco, Research Team on Health and Nutrition of Mother and Child, Faculty of Medicine and Pharmacy, Mohammed v University, Rabat, Morocco","Background. In Morocco, pediatric pneumonia remains a serious public health problem, as it constitutes the first cause of mortality due to infectious diseases. The etiological diagnosis of acute respiratory tract infections is difficult. Therefore, it is necessary to use Multiplex real-time polymerase chain reaction assay tests in a routine setting for exact and fast identification. Objectives. In this paper, we present the clinical results of pediatric pneumonia and describe their etiology by using molecular diagnosis. Study design: Tracheal secretion was collected from infants presenting respiratory distress isolated or associated with systemic signs, attending the unit of Neonatology between December 1, 2016, and Mai 31, 2018. Samples were tested with the multiplex RespiFinder® SMART 22 FAST which potentially detects 18 viruses and 4 bacteria. Results. Of the 86 infants considered in this study (mean age 31 ± 19 days) suspected of acute respiratory tract infections, 71 (83%) were positive for one or multiple viruses or/and bacteria. The majority of acute respiratory tract infections had a viral origin (95%): respiratory syncytial viruses (A and B) (49%), rhinovirus (21%), coronaviruses 229E (11%), humain metapneumovirus (5%), influenza A (3%), influenza H1N1 (1%), adenovirus (2%), and parainfluenza virus type 4 (2%). Among our patients, 6% had Mycoplasma pneumoniae. Coinfections were not associated with severe respiratory symptoms. Conclusion. The clinical spectrum of respiratory infections is complex and often nonspecific. Thus, the early and fast detection of related causative agents is crucial. The use of multiplex real time polymerase chain reaction may help choose an accurate treatment, reduce the overall use of unnecessary antibiotics, preserve intestinal flora, and decrease nosocomial infection by reducing the length of hospitalization. © 2020 Kenza Hattoufi et al.",,Adenoviridae; Article; bacterium detection; Coronavirinae; female; human; Human metapneumovirus; infant; Influenza A virus; Influenza A virus (H1N1); major clinical study; male; mixed infection; molecular diagnosis; Moroccan; multiplex real time polymerase chain reaction; Mycoplasma pneumoniae; Paramyxovirinae; pneumonia; Pneumovirus; respiratory distress; respiratory tract infection; Rhinovirus; symptom assessment; trachea mucus; virus detection,"Lynch, T., Bialy, L., Kellner, J.D., A systematic review on the diagnosis of pediatric bacterial pneumonia: When gold is bronze (2010) PLoS One, 5 (8). , e11989 2-s2.0-77957814302; Jroundi, I., Mahraoui, C., Benmessaoud, R., The epidemiology and aetiology of infections in children admitted with clinical severe pneumonia to a university hospital in Rabat, Morocco (2014) Journal of Tropical Pediatrics, 60 (4), pp. 270-278. , 2-s2.0-84905445292; 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Bruijnesteijn Van Coppenraet, L.E.S., Swanink, C.M.A., Van Zwet, A.A., Comparison of two commercial molecular assays for simultaneous detection of respiratory viruses in clinical samples using two automatic electrophoresis detection systems (2010) Journal of Virological Methods, 169 (1), pp. 188-192. , 2-s2.0-77956160231; Mengelle, C., Mansuy, J.M., Pierre, A., The use of a multiplex real-time PCR assay for diagnosing acute respiratory viral infections in children attending an emergency unit (2014) Journal of Clinical Virology, 61 (3), pp. 411-417. , 2-s2.0-84908551308; Pillet, S., Lardeux, M., Dina, J., Comparative evaluation of six commercialized multiplex PCR kits for the diagnosis of respiratory infections (2013) PLoS One, 8 (8), pp. 172-174. , 2-s2.0-84882945709; Mulholland, E.K., Simoes, E.A.F., Costales, M.O.D., McGrath, E.J., Manalac, E.M., Gove, S., Standardized diagnosis of pneumonia in developing countries (1992) The Pediatric Infectious Disease Journal, 11 (2), pp. 77-81. , 2-s2.0-0026602864; Dabisch-Ruthe, M., Vollmer, T., Adams, O., Knabbec, All, Comparison of three multiplex PCR assays for the detection of respiratory viral infections: Evaluation of xTAG respiratory virus panel fast assay, RespiFinder 19 assay and RespiFinder SMART 22 assay (2012) BMC Infectious Diseases, 12 (1), p. 163. , 2-s2.0-84870932152; Reijans, M., Dingemans, G., Klaassen, C.H., RespiFinder: A new multiparameter test to differentially identify fifteen respiratory viruses (2008) Journal of Clinical Microbiology, 46 (4), pp. 1232-1240. , 2-s2.0-42449155952; Martins Júnior, R.B., Carney, S., Goldemberg, D., Detection of respiratory viruses by real-time polymerase chain reaction in outpatients with acute respiratory infection (2014) Memórias Do Instituto Oswaldo Cruz, 109 (6), pp. 716-721. , 2-s2.0-84907191585; Health Organization/united Nations (who/un) Children'S Fund, W., (2009) Global Action Plan for Prevention and Control of Pneumonia (GAPP), , Geneva, Switzerland World Health Organization and the United Nations Children's Fund; Khor, C.S., Sam, I.C., Hooi, P.S., Quek, K.F., Chan, Y.F., Epidemiology and seasonality of respiratory viral infections in hospitalized children in Kuala Lumpur, Malaysia: A retrospective study of 27 years (2012) BMC Pediatrics, 12 (1), p. 32. , 2-s2.0-84858419813; Health Organization, W., (2009) CDC Protocol of Real Time RT-PCR for Swine Infl Uenza A (H1N1), , Atlanta, Georgia WHO; Goktas, S., Cem Sirin, M., Prevalence and seasonal distribution of respiratory viruses during the 2014-2015 season in istanbul (2016) Jundishapur Journal of Microbiology, 9 (9). , e39132 2-s2.0-84990840482; Mahony, J.B., Detection of respiratory viruses by molecular methods (2008) Clinical Microbiology Reviews, 21 (4), pp. 716-747. , 2-s2.0-54249126863; Raymaeker, M., De Rijke, B., Pauli, I., Van Den Abeele, A.-M., Cartuyvels, R., Timely diagnosis of respiratory tract infections: Evaluation of the performance of the Respifinder assay compared to the xTAG Respiratory Viral Panel assay (2011) Journal of Clinical Virology, 52 (4), pp. 314-316. , 2-s2.0-82755182647; Vallières, E., Renaud, C., Clinical and economical impact of multiplex respiratory virus assays (2013) Diagnostic Microbiology and Infectious Disease, 76 (3), pp. 255-261. , 2-s2.0-84879183994; Ruohola, A., Waris, M., Allander, T., Ziegler, T., Heikkinen, T., Ruuskanen, O., Viral etiology of common cold in children, Finland (2009) Emerging Infectious Diseases, 15 (2), pp. 344-346. , 2-s2.0-63849294962; Bhat, N., Tokarz, R., Jain, K., A Prospec-tive Study of Agents associated with acute respiratory infection among youngAmerican Indian children (2013) The Pediatric Infectious Disease Journal, 32, pp. e324-e333. , 2-s2.0-84880646369; Sonawane, A.A., Shastri, J., Bavdekar, S.B., Bavdekar, Respiratory pathogens in infants diagnosed with acute lower respiratory tract infection in a tertiary care hospital of western India using multiplex real time PCR (2019) The Indian Journal of Pediatrics, 86 (5), pp. 433-438. , 2-s2.0-85060139613; Nair, H., Nokes, D.J., Gessner, B.D., Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: A systematic review and meta-analysis (2010) The Lancet, 375 (9725), pp. 1545-1555. , 2-s2.0-77951653074; 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Ezzine, H., Cherkaoui, I., Oumzi, H., Epidemiologie de la grippe et facteurs de risque d'infection Respiratoire Aigue sévère au Maroc saisons 2016/2017 et 2017/2018 (2018) Bullettin d'Epidémiologie et de Santé Publique, 56, pp. 27-33; Canela, L.N.P., Magalhães-Barbosa, M.C.D., Raymundo, C.E., Viral detection profile in children with severe acute respiratory infection (2018) The Brazilian Journal of Infectious Diseases, 22 (5), pp. 402-411. , 2-s2.0-85056998451; Billaud, G., Morfin, F., Vabret, A., Human parainfluenza virus type 4 infections: A report of 20 cases from 1998 to 2002 (2005) Journal of Clinical Virology, 34 (1), pp. 48-51. , 2-s2.0-23744511958; Woo, P.C.Y., Lau, S.K.P., Chu, C.-M., Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia (2005) Journal of Virology, 79 (2), pp. 884-895. , 2-s2.0-19944427959; De-Paris, F., Beck, C., Pires, M.R., Santos, R.P.D., Kuchenbecker, R.D.S., Barth, A.L., Viral epidemiology of respiratory infections among children at a tertiary hospital in Southern Brazil (2014) Revista da Sociedade Brasileira de Medicina Tropical, 47 (2), pp. 223-226. , 2-s2.0-84901271892; Beckmann, C., Hirsch, H.H., Comparing luminex NxTAG-respiratory pathogen panel and RespiFinder-22 for multiplex detection of respiratory pathogens (2016) Journal of Medical Virology, 88 (8), pp. 1319-1324. , 2-s2.0-84975677686; Sly, P.D., Jones, C.M., Viral co-detection in infants hospitalized with respiratory disease: Is it important to detect? (2011) Journal de Pediatria, 87 (4), pp. 277-280. , 2-s2.0-80051752113; Cilla, G., Oñate, E., Perez-Yarza, E.G., Montes, M., Vicente, D., Perez-Trallero, E., Viruses in community-acquired pneumonia in children aged less than 3 years old: High rate of viral coinfection (2008) Journal of Medical Virology, 80 (10), pp. 1843-1849. , 2-s2.0-50849142594; De Paulis, M., Gilio, A.E., Ferraro, A.A., Severity of viral coinfection in hospitalized infants with respiratory syncytial virus infection (2011) Jornal de Pediatria, 87 (5), pp. 307-313. , 2-s2.0-80054853245; Singhi, S., Dhawan, A., Kataria, S., Walia, B.N., Clinical signs of pneumonia in infants under 2 months (1994) Archives of Disease in Childhood, 70 (5), pp. 413-417. , 2-s2.0-0028225191","Hattoufi, K.; National Reference Center in Neonatology and Nutrition, Children's Hospital, University Hospital Centre IBN SINAMorocco; email: kenzahattoufi@gmail.com",,Hindawi Limited,16878639,,,,English,Adv. Virol.,Article,Final,Open Access,Scopus,2-s2.0-85081037089,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Sunaga F., Tsuchiaka S., Kishimoto M., Aoki H., Kakinoki M., Kure K., Okumura H., Okumura M., Okumura A., Nagai M., Omatsu T., Mizutani T.",6602455776;55983176200;57188552304;54927496900;57215385861;55639724400;55640270100;57202097935;57203181544;26641337800;16430189600;57215384528;,Development of a one-run real-time pcr detection system for pathogens associated with porcine respiratory diseases,2020,Journal of Veterinary Medical Science,82,2,,217,223,,,10.1292/jvms.19-0063,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080842332&doi=10.1292%2fjvms.19-0063&partnerID=40&md5=9cc9c39a83106b7afad2698bfa25e1cc,"Laboratory of Infectious Disease, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Kanagawa, Sagamihara, 252-5201, Japan; Research and Education Center for Prevention of Global Infectious Diseases of Animals, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai, Tokyo, Fuchu, 183–8509, Japan; The United Graduate School of Veterinary Sciences, Gifu University, Yanagito, Gifu, 501-1193, Japan; Faculty of Veterinary Science, Nippon Veterinary and Life Science University, Musashino-shi, Tokyo, 180-8602, Japan; Value Farm Consulting Co., Ltd, 1704-3 Nishi Oi, Ibaraki, Tsukuba, 300-1260, Japan; Drexel University Dornsife School of Public Health, Philadelphia, PA 19104, United States; Centre for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY 10032, United States","Sunaga, F., Laboratory of Infectious Disease, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Kanagawa, Sagamihara, 252-5201, Japan; Tsuchiaka, S., Research and Education Center for Prevention of Global Infectious Diseases of Animals, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai, Tokyo, Fuchu, 183–8509, Japan, The United Graduate School of Veterinary Sciences, Gifu University, Yanagito, Gifu, 501-1193, Japan; Kishimoto, M., Research and Education Center for Prevention of Global Infectious Diseases of Animals, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai, Tokyo, Fuchu, 183–8509, Japan; Aoki, H., Faculty of Veterinary Science, Nippon Veterinary and Life Science University, Musashino-shi, Tokyo, 180-8602, Japan; Kakinoki, M., Laboratory of Infectious Disease, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Kanagawa, Sagamihara, 252-5201, Japan; Kure, K., Value Farm Consulting Co., Ltd, 1704-3 Nishi Oi, Ibaraki, Tsukuba, 300-1260, Japan; Okumura, H., Value Farm Consulting Co., Ltd, 1704-3 Nishi Oi, Ibaraki, Tsukuba, 300-1260, Japan; Okumura, M., Drexel University Dornsife School of Public Health, Philadelphia, PA 19104, United States; Okumura, A., Centre for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY 10032, United States; Nagai, M., Laboratory of Infectious Disease, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Kanagawa, Sagamihara, 252-5201, Japan, Research and Education Center for Prevention of Global Infectious Diseases of Animals, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai, Tokyo, Fuchu, 183–8509, Japan; Omatsu, T., Research and Education Center for Prevention of Global Infectious Diseases of Animals, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai, Tokyo, Fuchu, 183–8509, Japan, The United Graduate School of Veterinary Sciences, Gifu University, Yanagito, Gifu, 501-1193, Japan; Mizutani, T., Research and Education Center for Prevention of Global Infectious Diseases of Animals, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai, Tokyo, Fuchu, 183–8509, Japan, The United Graduate School of Veterinary Sciences, Gifu University, Yanagito, Gifu, 501-1193, Japan","The etiology of Porcine respiratory disease complex is complicated by infections with multiple pathogens, and multiple infections increase the difficulty in identifying the causal pathogen. In this present study, we developed a detection system of microbes from porcine respiratory by using TaqMan real-time PCR (referred to as Dempo-PCR) to screen a broad range of pathogens associated with porcine respiratory diseases in a single run. We selected 17 porcine respiratory pathogens (Actinobacillus pleuropneumoniae, Boldetella bronchiseptica, Haemophilus parasuis, Pasteurella multocida, Pasteurella multocida toxin, Streptococcus suis, Mycoplasma hyopneumoniae, Mycoplasma hyorhinis, Mycoplasma hyosynovie, porcine circovirus 2, pseudorabies virus, porcine cytomegalovirus, swine influenza A virus, porcine reproductive and respiratory virus US strain, EU strain, porcine respiratory coronavirus and porcine hemagglutinating encephalomyelitis virus) as detection targets and designed novel specific primer-probe sets for seven of them. In sensitivity test by using standard curves from synthesized DNA, all primer-probe sets showed high sensitivity. However, porcine reproductive and respiratory virus is known to have a high frequency of genetic mutations, and the primer and probe sequences will need to be checked at a considerable frequency when performing Dempo-PCR from field samples. A total of 30 lung samples from swine showing respiratory symptoms on six farms were tested by the Dempo-PCR to validate the assay’s clinical performance. As the results, 12 pathogens (5 virus and 7 bacteria) were detected and porcine reproductive and respiratory virus US strain, Mycoplasma hyorhinis, Haemophilus parasuis, and porcine cytomegalovirus were detected at high frequency. These results suggest that Dempo-PCR assay can be applied as a screening system with wide detection targets. ©2020 The Japanese Society of Veterinary Science.",Diagnosis; Porcine; Respiratory disease; TaqMan real-time PCR,bacterial DNA; beta actin; virus DNA; Actinobacillus pleuropneumoniae; animal experiment; animal model; animal tissue; Article; bacterial strain; bacterium detection; Boldetella bronchiseptica; clinical evaluation; controlled study; disease association; DNA extraction; DNA synthesis; gene amplification; gene expression; gene sequence; infectious agent; limit of detection; linearity; mixed infection; nonhuman; Pasteurella multocida; pig; real time polymerase chain reaction; reproducibility; respiratory tract disease; RNA extraction; screening test; sensitivity and specificity; virus detection,"Angen, O., Jensen, J., Lavritsen, D.T., Evaluation of 5′ nuclease assay for detection of Actinobacillus pleuropneumoniae (2001) J. Clin. Microbiol., 39, pp. 260-265; Bonifait, L., Veillette, M., Létourneau, V., Grenier, D., Duchaine, C., Detection of streptococcus suis in bioaerosols of swine confinement buildings Appl. Environ. Microbiol., 80, pp. 3296-3304; Edington, N., Wrathall, A.E., Done, J.T., Porcine cytomegalovirus (PCMV) in early gestation (1988) Vet. Microbiol., 17, pp. 117-128; Giammarioli, M., Pellegrini, C., Casciari, C., de Mia, G.M., Development of a novel hot-start multiplex PCR for simultaneous detection of classical swine fever virus, African swine fever virus, porcine circovirus type 2, porcine reproductive and respiratory syndrome virus and porcine parvovirus (2008) Vet. Res. Commun., 32, pp. 255-262; Grau-Roma, L., Segalés, J., Detection of porcine reproductive and respiratory syndrome virus, porcine circovirus type 2, swine influenza virus and Aujeszky’s disease virus in cases of porcine proliferative and necrotizing pneumonia (PNP) in Spain (2007) Vet. Microbiol., 119, pp. 144-151; Gu, W., Zeng, N., Zhou, L., Ge, X., Guo, X., Yang, H., Genomic organization and molecular characterization of porcine cytomegalovirus (2014) Virology, 460-461, pp. 165-172; Hansen, M.S., Pors, S.E., Jensen, H.E., Bille-Hansen, V., Bisgaard, M., Flachs, E.M., Nielsen, O.L., An investigation of the pathology and pathogens associated with porcine respiratory disease complex in Denmark (2010) J. Comp. Pathol., 143, pp. 120-131; Harms, P.A., Halbur, P.G., Sorden, S.D., Three cases of porcine respiratory disease complex associated with porcine circovirus type 2 infection (2002) J. Swine Health Prod., 10, pp. 27-30; Hernandez-Garcia, J., Robben, N., Magnée, D., Eley, T., Dennis, I., Kayes, S.M., Thomson, J.R., Tucker, A.W., The use of oral fluids to monitor key pathogens in porcine respiratory disease complex (2017) Porcine Health Manag, 3, p. 7; Hirahara, T., Yasuhara, H., Matsui, O., Izumida, A., Yoshiki, K., Fukuyama, S., Kodama, K., Sasaki, N., Survey of porcine hemagglutinating encephalomyelitis virus infection of pigs in Japan (1989) Nippon Juishikai Zasshi, 42, pp. 867-870. , in Japanese; Kishimoto, M., Tsuchiaka, S., Rahpaya, S.S., Hasebe, A., Otsu, K., Sugimura, S., Kobayashi, S., Mizutani, T., Development of a one-run real-time PCR detection system for pathogens associated with bovine respiratory disease complex (2017) J. Vet. Med. Sci., 79, pp. 517-523; Kleiboeker, S.B., Schommer, S.K., Lee, S.M., Watkins, S., Chittick, W., Polson, D., Simultaneous detection of North American and European porcine reproductive and respiratory syndrome virus using real-time quantitative reverse transcriptase-PCR (2005) J. Vet. Diagn. Invest., 17, pp. 165-170; Lin, K., Wang, C., Murtaugh, M.P., Ramamoorthy, S., Multiplex method for simultaneous serological detection of porcine reproductive and respiratory syndrome virus and porcine circovirus type 2 (2011) J. Clin. Microbiol., 49, pp. 3184-3190; Lorbach, J.N., Wang, L., Nolting, J.M., Benjamin, M.G., Killian, M.L., Zhang, Y., Bowman, A.S., Porcine hemagglutinating encephalomyelitis virus and respiratory disease in exhibition swine, Michigan, USA, 2015 (2017) Emerg. Infect. Dis., 23, pp. 1168-1171; Lung, O., Ohene-Adjei, S., Buchanan, C., Joseph, T., King, R., Erickson, A., Detmer, S., Ambagala, A., Multiplex PCR and microarray for detection of swine respiratory pathogens (2017) Transbound. Emerg. Dis., 64, pp. 834-848; Ma, W., Lager, K.M., Richt, J.A., Stoffregen, W.C., Zhou, F., Yoon, K.J., Development of real-time polymerase chain reaction assays for rapid detection and differentiation of wild-type pseudorabies and gene-deleted vaccine viruses (2008) J. Vet. Diagn. Invest., 20, pp. 440-447; Maes, D., Deluyker, H., Verdonck, M., Castryck, F., Miry, C., Vrijens, B., de Kruif, A., Herd factors associated with the seroprevalences of four major respiratory pathogens in slaughter pigs from farrow-to-finish pig herds (2000) Vet. Res., 31, pp. 313-327; Marois, C., Dory, D., Fablet, C., Madec, F., Kobisch, M., Development of a quantitative Real-Time TaqMan PCR assay for determination of the minimal dose of Mycoplasma hyopneumoniae strain 116 required to induce pneumonia in SPF pigs (2010) J. Appl. Microbiol., 108, pp. 1523-1533; Masuda, T., Tsuchiaka, S., Ashiba, T., Yamasato, H., Fukunari, K., Omatsu, T., Furuya, T., Nagai, M., Development of one-step real-time reverse transcriptase-PCR-based assays for the rapid and simultaneous detection of four viruses causing porcine diarrhea (2016) Jpn. J. Vet. Res., 64, pp. 5-14; Opriessnig, T., Giménez-Lirola, L.G., Halbur, P.G., Polymicrobial respiratory disease in pigs (2011) Anim. Health Res. Rev., 12, pp. 133-148; Rech, R.R., Gava, D., Silva, M.C., Fernandes, L.T., Haach, V., Ciacci-Zanella, J.R., Schaefer, R., Porcine respiratory disease complex after the introduction of H1N1/2009 influenza virus in Brazil (2018) Zoonoses Public Health, 65, pp. e155-e161; Schmidt, C., Cibulski, S.P., Andrade, C.P., Teixeira, T.F., Varela, A.P.M., Scheffer, C.M., Franco, A.C., Roehe, P.M., Swine influenza virus and association with the porcine respiratory disease complex in pig farms in Southern Brazil (2016) Zoonoses Public Health, 63, pp. 234-240; Tang, X., Zhao, Z., Hu, J., Wu, B., Cai, X., He, Q., Chen, H., Isolation, antimicrobial resistance, and virulence genes of Pasteurella multocida strains from swine in China (2009) J. Clin. Microbiol., 47, pp. 951-958; Tizolova, A., Brun, D., Guiso, N., Guillot, S., Development of real-time PCR assay for differential detection of Bordetella bronchiseptica and Bordetella parapertussis (2014) Diagn. Microbiol. Infect. Dis., 78, pp. 347-351; Tocqueville, V., Ferré, S., Nguyen, N.H.P., Kempf, I., Marois-Créhan, C., Multilocus sequence typing of Mycoplasma hyorhinis strains identified by a real-time TaqMan PCR assay (2014) J. Clin. Microbiol., 52, pp. 1664-1671; Tsuchiaka, S., Masuda, T., Sugimura, S., Kobayashi, S., Komatsu, N., Nagai, M., Omatsu, T., Mizutani, T., Development of a novel detection system for microbes from bovine diarrhea by real-time PCR (2016) J. Vet. Med. Sci., 78, pp. 383-389; Turni, C., Pyke, M., Blackall, P.J., Validation of a real-time PCR for Haemophilus parasuis (2010) J. Appl. Microbiol., 108, pp. 1323-1331; Wernike, K., Hoffmann, B., Dauber, M., Lange, E., Schirrmeier, H., Beer, M., Detection and typing of highly pathogenic porcine reproductive and respiratory syndrome virus by multiplex real-time rt-PCR (2012) Plos One, 7; Wernike, K., Hoffmann, B., Kalthoff, D., König, P., Beer, M., Development and validation of a triplex real-time PCR assay for the rapid detection and differentiation of wild-type and glycoprotein E-deleted vaccine strains of bovine herpesvirus type 1 (2011) J. Virol. Methods, 174, pp. 77-84","Sunaga, F.; Laboratory of Infectious Disease, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Kanagawa, Japan; email: sunaga@azabu-u.ac.jp",,Japanese Society of Veterinary Science,9167250,,,31866601,English,J. Vet. Med. Sci.,Article,Final,Open Access,Scopus,2-s2.0-85080842332,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Lewandowski K., Xu Y., Pullan S.T., Lumley S.F., Foster D., Sanderson N., Vaughan A., Morgan M., Bright N., Kavanagh J., Vipond R., Carroll M., Marriott A.C., Gooch K.E., Andersson M., Jeffery K., Peto T.E.A., Crook D.W., Sarah Walker A., Matthews P.C.",56769201900;57215633329;8209342500;55792373000;24070425200;56443821000;36097031900;7403025417;57210123616;57211575571;13106154300;7402388114;57204294984;8255276100;26767564800;35290551400;7005772816;7102132600;6503849350;57203255155;,Metagenomic nanopore sequencing of influenza virus direct from clinical respiratory samples,2020,Journal of Clinical Microbiology,58,1, e00963-19,,,,2,10.1128/JCM.00963-19,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077224700&doi=10.1128%2fJCM.00963-19&partnerID=40&md5=7338c648ee4e2da2d7d5ba48707e8e9f,"Public Health England, National infection Service, Porton Down, Salisbury, United Kingdom; Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, United Kingdom; Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Headington, Oxford, United Kingdom; Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Oxford NIHR BRC, John Radcliffe Hospital, Headington, Oxford, United Kingdom","Lewandowski, K., Public Health England, National infection Service, Porton Down, Salisbury, United Kingdom; Xu, Y., Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, United Kingdom, Oxford NIHR BRC, John Radcliffe Hospital, Headington, Oxford, United Kingdom; Pullan, S.T., Public Health England, National infection Service, Porton Down, Salisbury, United Kingdom; Lumley, S.F., Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Headington, Oxford, United Kingdom; Foster, D., Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, United Kingdom, Oxford NIHR BRC, John Radcliffe Hospital, Headington, Oxford, United Kingdom; Sanderson, N., Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, United Kingdom, Oxford NIHR BRC, John Radcliffe Hospital, Headington, Oxford, United Kingdom; Vaughan, A., Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, United Kingdom, Oxford NIHR BRC, John Radcliffe Hospital, Headington, Oxford, United Kingdom; Morgan, M., Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Headington, Oxford, United Kingdom; Bright, N., Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, United Kingdom; Kavanagh, J., Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, United Kingdom; Vipond, R., Public Health England, National infection Service, Porton Down, Salisbury, United Kingdom; Carroll, M., Public Health England, National infection Service, Porton Down, Salisbury, United Kingdom; Marriott, A.C., Public Health England, National infection Service, Porton Down, Salisbury, United Kingdom; Gooch, K.E., Public Health England, National infection Service, Porton Down, Salisbury, United Kingdom; Andersson, M., Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Headington, Oxford, United Kingdom; Jeffery, K., Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Headington, Oxford, United Kingdom; Peto, T.E.A., Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, United Kingdom, Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Headington, Oxford, United Kingdom, Oxford NIHR BRC, John Radcliffe Hospital, Headington, Oxford, United Kingdom; Crook, D.W., Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, United Kingdom, Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Headington, Oxford, United Kingdom, Oxford NIHR BRC, John Radcliffe Hospital, Headington, Oxford, United Kingdom; Sarah Walker, A., Nuffield Department of Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, United Kingdom; Matthews, P.C., Department of Infectious Diseases and Microbiology, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Headington, Oxford, United Kingdom, Peter Medawar Building for Pathogen Research, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Oxford NIHR BRC, John Radcliffe Hospital, Headington, Oxford, United Kingdom","Influenza is a major global public health threat as a result of its highly pathogenic variants, large zoonotic reservoir, and pandemic potential. Metagenomic viral sequencing offers the potential for a diagnostic test for influenza virus which also provides insights on transmission, evolution, and drug resistance and simultaneously detects other viruses. We therefore set out to apply the Oxford Nanopore Technologies sequencing method to metagenomic sequencing of respiratory samples. We generated influenza virus reads down to a limit of detection of 102 to 103 genome copies/ml in pooled samples, observing a strong relationship between the viral titer and the proportion of influenza virus reads (P= 4.7 × 10-5). Applying our methods to clinical throat swabs, we generated influenza virus reads for 27/27 samples with mid-to-high viral titers (cycle threshold [CT] values, <30) and 6/13 samples with low viral titers (CT values, 30 to 40). No false-positive reads were generated from 10 influenza virus-negative samples. Thus, Nanopore sequencing operated with 83% sensitivity (95% confidence interval [CI], 67 to 93%) and 100% specificity (95% CI, 69 to 100%) compared to the current diagnostic standard. Coverage of full-length virus was dependent on sample composition, being negatively influenced by increased host and bacterial reads. However, at high influenza virus titers, we were able to reconstruct >99% complete sequences for all eight gene segments. We also detected a human coronavirus coinfection in one clinical sample. While further optimization is required to improve sensitivity, this approach shows promise for the Nanopore platform to be used in the diagnosis and genetic analysis of influenza virus and other respiratory viruses. Copyright © 2019 Lewandowski et al.",Diagnosis; Diagnostics; DNA sequencing; Epidemiology; Influenza; Metagenomic; Metagenomics; Molecular epidemiology; Nanopore; Sequencing,virus RNA; Article; cohort analysis; controlled study; Coronavirus infection; diagnostic accuracy; diagnostic test; diagnostic test accuracy study; genetic analysis; human; human tissue; Influenza virus; intermethod comparison; limit of detection; metagenomics; mixed infection; nonhuman; priority journal; sensitivity and specificity; sequence analysis; throat culture; virus detection; virus genome; virus identification; virus load,"Krammer, F., Smith, G.J.D., Fouchier, R.A.M., Peiris, M., Kedzierska, K., Doherty, P.C., Palese, P., García-Sastre, A., Influenza (2018) Nat Rev Dis Primers, 4, p. 3. , https://doi.org/10.1038/s41572-018-0002-y; Joseph, U., Su, Y.C.F., Vijaykrishna, D., Smith, G., The ecology and adaptive evolution of influenza a interspecies transmission (2017) Influenza Other Respir Viruses, 11, pp. 74-84. , https://doi.org/10.1111/irv.12412; Humphreys, M., The influenza of 1918: Evolutionary perspectives in a historical context (2018) Evol Med Public Health, 2018, pp. 219-229. , https://doi.org/10.1093/emph/eoy024; Smith, G.J.D., Vijaykrishna, D., Bahl, J., Lycett, S.J., Worobey, M., Pybus, O.G., Ma, S.K., Rambaut, A., Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza a epidemic (2009) Nature, 459, pp. 1122-1125. , https://doi.org/10.1038/nature08182; Sutton, T.C., The pandemic threat of emerging h5 and h7 avian influenza viruses (2018) Viruses, 10, p. 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Clin. Microbiol.,Article,Final,Open Access,Scopus,2-s2.0-85077224700,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Tsou P., Vadivelan A., Kovvuri M., Garg N., Thangavelu M., Wang Y., Raj S.",57212089383;57212087117;57212087420;57212088589;57212087962;57212092812;57213983164;,Association between multiple respiratory viral infections and pediatric intensive care unit admission among infants with bronchiolitis,2020,Archives de Pediatrie,27,1,,39,44,,,10.1016/j.arcped.2019.11.006,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85075856024&doi=10.1016%2fj.arcped.2019.11.006&partnerID=40&md5=b278e48c904689ece3b97126b3dd3440,"Department of Pediatrics, Driscoll Children's Hospital/Texas A&M College of Medicine, Corpus Christi, TX, United States; Department of Critical Care Medicine, Driscoll Children's Hospital/Texas A&M College of Medicine, Corpus Christi, TX, United States","Tsou, P., Department of Pediatrics, Driscoll Children's Hospital/Texas A&M College of Medicine, Corpus Christi, TX, United States; Vadivelan, A., Department of Pediatrics, Driscoll Children's Hospital/Texas A&M College of Medicine, Corpus Christi, TX, United States; Kovvuri, M., Department of Pediatrics, Driscoll Children's Hospital/Texas A&M College of Medicine, Corpus Christi, TX, United States; Garg, N., Department of Pediatrics, Driscoll Children's Hospital/Texas A&M College of Medicine, Corpus Christi, TX, United States; Thangavelu, M., Department of Pediatrics, Driscoll Children's Hospital/Texas A&M College of Medicine, Corpus Christi, TX, United States; Wang, Y., Department of Pediatrics, Driscoll Children's Hospital/Texas A&M College of Medicine, Corpus Christi, TX, United States; Raj, S., Department of Critical Care Medicine, Driscoll Children's Hospital/Texas A&M College of Medicine, Corpus Christi, TX, United States","Background: It is unclear whether multiple respiratory viral infections are associated with more severe bronchiolitis requiring pediatric intensive care unit (PICU) admission. We aimed to identify the association between multiple respiratory viral infections and PICU admission among infants with bronchiolitis. Methods: We performed a 1:1 case-control study enrolling previously healthy full-term infants (≤12 months) with bronchiolitis admitted to the PICU as cases and those to the general pediatric ward as controls from 2015 to 2017. Multiplex polymerase chain reaction (PCR) was used for detection of the respiratory viruses. We summarized the characteristics of infants admitted to the PICU and the general pediatric unit. Multivariable logistic regression analysis was used to fit the association between multiple respiratory viral infections (≥2 strains) and PICU admission. Results: A total of 135 infants admitted to the PICU were compared with 135 randomly selected control infants admitted to the general pediatric unit. The PICU patients were younger (median: 2.2 months, interquartile range: 1.3–4.2) than the general ward patients (median: 3.2 months, interquartile range: 1.6–6.4). Respiratory syncytial virus (74.1%), rhinovirus (28.9%), and coronavirus (5.9%) were the most common viruses for bronchiolitis requiring PICU admission. Patients with bronchiolitis admitted to the PICU tended to have multiple viral infections compared with patients on the general ward (23.0% vs. 10.4%, P < 0.001). In the multivariable logistic regression analysis, bronchiolitis with multiple viral infections was associated with higher odds of PICU admission (adjusted odds ratio: 2.56, 95% confidence interval: 1.17–5.57, P = 0.02). Conclusion: Infants with multiviral bronchiolitis have higher odds of PICU admission compared with those with a single or nondetectable viral infection. © 2019 French Society of Pediatrics",Bronchiolitis; Infants; Multiple respiratory viral; Pediatric intensive care,antibiotic agent; bronchodilating agent; corticosteroid; oxygen; steroid; Article; case control study; controlled study; Coronavirinae; disease association; female; gestational age; high risk patient; hospital admission; hospital based case control study; hospital department; human; Human respiratory syncytial virus; hypoxia; infant; major clinical study; male; mixed infection; multiplex polymerase chain reaction; newborn; pediatric intensive care unit; pediatric ward; respiratory virus; retrospective study; Rhinovirus; viral bronchiolitis; viral respiratory tract infection; virus detection; virus strain,"Florin, T.A., Plint, A.C., Zorc, J.J., Viral bronchiolitis (2017) Lancet, 389, pp. 211-224; Pelletier, A.J., Mansbach, J.M., Camargo, C.A., Jr., Direct medical costs of bronchiolitis hospitalizations in the United States (2006) Pediatrics, 118, pp. 2418-2423; 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Marguet, C., Lubrano, M., Gueudin, M., In very young infants severity of acute bronchiolitis depends on carried viruses (2009) PLoS One, 4, p. e4596; Brand, H.K., de Groot, R., Galama, J.M., Infection with multiple viruses is not associated with increased disease severity in children with bronchiolitis (2012) Pediatr Pulmonol, 47, pp. 393-400; Papadopoulos, N.G., Moustaki, M., Tsolia, M., Association of rhinovirus infection with increased disease severity in acute bronchiolitis (2002) Am J Respir Crit Care Med, 165, pp. 1285-1289; Nascimento, M.S., Souza, A.V., Ferreira, A.V., High rate of viral identification and coinfections in infants with acute bronchiolitis (2010) Clinics (Sao Paulo), 65, pp. 1133-1137; Leber, A.L., Everhart, K., Daly, J.A., Multicenter evaluation of biofire filmarray respiratory panel 2 for detection of viruses and bacteria in nasopharyngeal Swab samples (2018) J Clin Microbiol, p. 56; Jartti, T., Lehtinen, P., Vuorinen, T., Bronchiolitis: age and previous wheezing episodes are linked to viral etiology and atopic characteristics (2009) Pediatr Infect Dis J, 28, pp. 311-317; Oymar, K., Skjerven, H.O., Mikalsen, I.B., Acute bronchiolitis in infants, a review (2014) Scand J Trauma Resusc Emerg Med, 22, p. 23; Robinson, R.F., Impact of respiratory syncytial virus in the United States (2008) Am J Health Syst Pharm, 65, pp. S3-S6; Ghazaly, M., Nadel, S., Characteristics of children admitted to intensive care with acute bronchiolitis (2018) Eur J Pediatr, 177, pp. 913-920; Robledo-Aceves, M., Moreno-Peregrina, M.J., Velarde-Rivera, F., Risk factors for severe bronchiolitis caused by respiratory virus infections among Mexican children in an emergency department (2018) Medicine, 97, p. e0057; Bosch, A.A., Biesbroek, G., Trzcinski, K., Viral and bacterial interactions in the upper respiratory tract (2013) PLoS Pathog, 9, p. e1003057; Krause, J.C., Panning, M., Hengel, H., The role of multiplex PCR in respiratory tract infections in children (2014) Dtsch Arztebl Int, 111, pp. 639-645; Loeffelholz, M.J., Trujillo, R., Pyles, R.B., Duration of rhinovirus shedding in the upper respiratory tract in the first year of life (2014) Pediatrics, 134, pp. 1144-1150; Munywoki, P.K., Koech, D.C., Agoti, C.N., Influence of age, severity of infection, and co-infection on the duration of respiratory syncytial virus (RSV) shedding (2015) Epidemiol Infect, 143, pp. 804-812; Hanada, S., Pirzadeh, M., Carver, K.Y., Respiratory viral infection-induced microbiome alterations and secondary bacterial pneumonia (2018) Front Immunol, 9, p. 2640; Wu, P., Hartert, T.V., Evidence for a causal relationship between respiratory syncytial virus infection and asthma (2011) Expert Rev Anti Infect Ther, 9, pp. 731-745; Wishaupt, J.O., Russcher, A., Smeets, L.C., Clinical impact of RT-PCR for pediatric acute respiratory infections: a controlled clinical trial (2011) Pediatrics, 128, pp. e1113-e11120; Doan, Q., Enarson, P., Kissoon, N., Rapid viral diagnosis for acute febrile respiratory illness in children in the Emergency Department (2012) Cochrane Database Syst Rev, , [CD006452]","Tsou, P.; Department of Pediatrics, Driscoll Children's Hospital/Texas A&M College of Medicine, 3533 S. Alameda street, United States; email: poyangtsou@gmail.com",,Elsevier Masson SAS,0929693X,,APEDE,31780096,English,Arch. Pediatr.,Article,Final,Open Access,Scopus,2-s2.0-85075856024,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Rodriguez-Morales A.J., Cardona-Ospina J.A., Gutiérrez-Ocampo E., Villamizar-Peña R., Holguin-Rivera Y., Escalera-Antezana J.P., Alvarado-Arnez L.E., Bonilla-Aldana D.K., Franco-Paredes C., Henao-Martinez A.F., Paniz-Mondolfi A., Lagos-Grisales G.J., Ramírez-Vallejo E., Suárez J.A., Zambrano L.I., Villamil-Gómez W.E., Balbin-Ramon G.J., Rabaan A.A., Harapan H., Dhama K., Nishiura H., Kataoka H., Ahmad T., Sah R., Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19)",8886801000;56436616100;57215012986;57214989566;56671341500;56993859600;37036884900;57208153819;7003449834;54932176400;8331702100;55861598000;36060100700;57205844685;55497039300;13604798600;57214601024;56049830800;55844857500;6507396956;7005501836;57215834338;57214283386;57195544674;,"Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis",2020,Travel Medicine and Infectious Disease,,,101623,,,,,10.1016/j.tmaid.2020.101623,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082005057&doi=10.1016%2fj.tmaid.2020.101623&partnerID=40&md5=df985d2f1b4f0780933d2df2d679eb70,"Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia; Grupo de Investigación Biomedicina, Faculty of Medicine, Fundación Universitaria Autónoma de las Américas, Pereira, Risaralda, Colombia; Comittee on Tropical Medicine, Zoonoses and Travel Medicina, Asociación Colombiana de Infectología, Bogotá, DC, Colombia; Committe on Travel Medicine, Pan-American Association of Infectious Diseases (API), Pereira, Risaralda, Colombia; Master in Clinical Epidemiology and Biostatistics, Universidad Cientifica del Sur, Lima, Peru; Grupo de Investigación Infección e Inmunidad, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia; Semillero de Investigación en Infecciones Emergentes y Medicina Tropical, Faculty of Medicine, Fundación Universitaria Autónoma de las Américas, Pereira, Risaralda, Colombia; Emerging Infectious Diseases and Tropical Medicine Research Group, Instituto para la Investigación en Ciencias Biomédicas – Sci-Help, Pereira, Risaralda, Colombia; Universidad Franz Tamayo/UNIFRANZ, Cochabamba, Bolivia; National Responsible for Telehealth Program, Ministry of Health, La Paz, Bolivia; Incubator in Zoonosis (SIZOO), Biodiversity and Ecosystem Conservation Research Group (BIOECOS), Fundación Universitaria Autónoma de las Américas, Sede Pereira, Pereira, Risaralda, Colombia; Division of Infectious Diseases, Department of Medicine, University of Colorado Anschutz Medical Center, Aurora, CO, United States; Hospital Infantil de México Federico Gómez, México City, Mexico; Laboratory of Medical Microbiology, Department of Pathology, Molecular and Cell-based Medicine, The Mount Sinai Hospital-Icahn School of Medicine at Mount Sinai, New York, United States; Laboratorio de Señalización Celular y Bioquímica de Parásitos, Instituto de Estudios Avanzados (IDEA), Caracas, Caracas, Venezuela; Academia Nacional de Medicina, Caracas, Venezuela; Instituto de Investigaciones Biomedicas IDB / Incubadora Venez/olana de la Ciencia, Cabudare, Edo. Lara, Venezuela; Investigador SNI Senacyt Panamá, Clinical Research Deparment, Instituto Conmemorativo Gorgas de Estudios de la Salud, Panamá City, Panama; Department of Physiological and Morphological Sciences, School of Medical, Sciences, Universidad Nacional Autónoma de Honduras (UNAH), Tegucigalpa, Honduras; Infectious Diseases and Infection Control Research Group, Hospital Universitario de Sincelejo, Sincelejo, Sucre, Colombia; Programa del Doctorado de Medicina Tropical, SUE Caribe, Universidad del Atlántico, Barranquilla, Colombia; Hospital de Emergencias Jose Casimiro Ulloa, Lima, Peru; Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia; Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia; Tropical Disease Centre, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia; Department of Microbiology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia; Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh 243 122, India; Graduate School of Medicine, Hokkaido University, Kita 15 Jo Nishi 7 Chome, Kita-ku, Sapporo-shi, Hokkaido, 060-8638, Japan; Hamamatsu University School of Medicine, Internal Medicine 3rd Division, Department of Cardiology, Hamamatsu, Shizuoka, Japan; Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, 210009, China; Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, China; Department of Microbiology, Tribhuvan University Teaching Hospital, Institute of Medicine, Kathmandu, Nepal","Rodriguez-Morales, A.J., Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia, Grupo de Investigación Biomedicina, Faculty of Medicine, Fundación Universitaria Autónoma de las Américas, Pereira, Risaralda, Colombia, Comittee on Tropical Medicine, Zoonoses and Travel Medicina, Asociación Colombiana de Infectología, Bogotá, DC, Colombia, Committe on Travel Medicine, Pan-American Association of Infectious Diseases (API), Pereira, Risaralda, Colombia, Master in Clinical Epidemiology and Biostatistics, Universidad Cientifica del Sur, Lima, Peru; Cardona-Ospina, J.A., Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia, Grupo de Investigación Biomedicina, Faculty of Medicine, Fundación Universitaria Autónoma de las Américas, Pereira, Risaralda, Colombia, Comittee on Tropical Medicine, Zoonoses and Travel Medicina, Asociación Colombiana de Infectología, Bogotá, DC, Colombia, Committe on Travel Medicine, Pan-American Association of Infectious Diseases (API), Pereira, Risaralda, Colombia, Grupo de Investigación Infección e Inmunidad, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia, Semillero de Investigación en Infecciones Emergentes y Medicina Tropical, Faculty of Medicine, Fundación Universitaria Autónoma de las Américas, Pereira, Risaralda, Colombia, Emerging Infectious Diseases and Tropical Medicine Research Group, Instituto para la Investigación en Ciencias Biomédicas – Sci-Help, Pereira, Risaralda, Colombia; Gutiérrez-Ocampo, E., Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia; Villamizar-Peña, R., Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia; Holguin-Rivera, Y., Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia; Escalera-Antezana, J.P., Universidad Franz Tamayo/UNIFRANZ, Cochabamba, Bolivia, National Responsible for Telehealth Program, Ministry of Health, La Paz, Bolivia; Alvarado-Arnez, L.E., Universidad Franz Tamayo/UNIFRANZ, Cochabamba, Bolivia; Bonilla-Aldana, D.K., Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia, Comittee on Tropical Medicine, Zoonoses and Travel Medicina, Asociación Colombiana de Infectología, Bogotá, DC, Colombia, Incubator in Zoonosis (SIZOO), Biodiversity and Ecosystem Conservation Research Group (BIOECOS), Fundación Universitaria Autónoma de las Américas, Sede Pereira, Pereira, Risaralda, Colombia; Franco-Paredes, C., Committe on Travel Medicine, Pan-American Association of Infectious Diseases (API), Pereira, Risaralda, Colombia, Division of Infectious Diseases, Department of Medicine, University of Colorado Anschutz Medical Center, Aurora, CO, United States, Hospital Infantil de México Federico Gómez, México City, Mexico; Henao-Martinez, A.F., Division of Infectious Diseases, Department of Medicine, University of Colorado Anschutz Medical Center, Aurora, CO, United States; Paniz-Mondolfi, A., Committe on Travel Medicine, Pan-American Association of Infectious Diseases (API), Pereira, Risaralda, Colombia, Laboratory of Medical Microbiology, Department of Pathology, Molecular and Cell-based Medicine, The Mount Sinai Hospital-Icahn School of Medicine at Mount Sinai, New York, United States, Laboratorio de Señalización Celular y Bioquímica de Parásitos, Instituto de Estudios Avanzados (IDEA), Caracas, Caracas, Venezuela, Academia Nacional de Medicina, Caracas, Venezuela, Instituto de Investigaciones Biomedicas IDB / Incubadora Venez/olana de la Ciencia, Cabudare, Edo. Lara, Venezuela; Lagos-Grisales, G.J., Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia; Ramírez-Vallejo, E., Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia; Suárez, J.A., Comittee on Tropical Medicine, Zoonoses and Travel Medicina, Asociación Colombiana de Infectología, Bogotá, DC, Colombia, Investigador SNI Senacyt Panamá, Clinical Research Deparment, Instituto Conmemorativo Gorgas de Estudios de la Salud, Panamá City, Panama; Zambrano, L.I., Department of Physiological and Morphological Sciences, School of Medical, Sciences, Universidad Nacional Autónoma de Honduras (UNAH), Tegucigalpa, Honduras; Villamil-Gómez, W.E., Comittee on Tropical Medicine, Zoonoses and Travel Medicina, Asociación Colombiana de Infectología, Bogotá, DC, Colombia, Committe on Travel Medicine, Pan-American Association of Infectious Diseases (API), Pereira, Risaralda, Colombia, Infectious Diseases and Infection Control Research Group, Hospital Universitario de Sincelejo, Sincelejo, Sucre, Colombia, Programa del Doctorado de Medicina Tropical, SUE Caribe, Universidad del Atlántico, Barranquilla, Colombia; Balbin-Ramon, G.J., Master in Clinical Epidemiology and Biostatistics, Universidad Cientifica del Sur, Lima, Peru, Hospital de Emergencias Jose Casimiro Ulloa, Lima, Peru; Rabaan, A.A., Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia; Harapan, H., Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia, Tropical Disease Centre, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia, Department of Microbiology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia; Dhama, K., Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh 243 122, India; Nishiura, H., Graduate School of Medicine, Hokkaido University, Kita 15 Jo Nishi 7 Chome, Kita-ku, Sapporo-shi, Hokkaido, 060-8638, Japan; Kataoka, H., Hamamatsu University School of Medicine, Internal Medicine 3rd Division, Department of Cardiology, Hamamatsu, Shizuoka, Japan; Ahmad, T., Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, 210009, China, Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, China; Sah, R., Department of Microbiology, Tribhuvan University Teaching Hospital, Institute of Medicine, Kathmandu, Nepal; Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19)","Introduction: An epidemic of Coronavirus Disease 2019 (COVID-19) began in December 2019 in China leading to a Public Health Emergency of International Concern (PHEIC). Clinical, laboratory, and imaging features have been partially characterized in some observational studies. No systematic reviews on COVID-19 have been published to date. Methods: We performed a systematic literature review with meta-analysis, using three databases to assess clinical, laboratory, imaging features, and outcomes of COVID-19 confirmed cases. Observational studies and also case reports, were included, and analyzed separately. We performed a random-effects model meta-analysis to calculate pooled prevalences and 95% confidence intervals (95%CI). Results: 660 articles were retrieved for the time frame (1/1/2020-2/23/2020). After screening, 27 articles were selected for full-text assessment, 19 being finally included for qualitative and quantitative analyses. Additionally, 39 case report articles were included and analyzed separately. For 656 patients, fever (88.7%, 95%CI 84.5–92.9%), cough (57.6%, 95%CI 40.8–74.4%) and dyspnea (45.6%, 95%CI 10.9–80.4%) were the most prevalent manifestations. Among the patients, 20.3% (95%CI 10.0–30.6%) required intensive care unit (ICU), 32.8% presented with acute respiratory distress syndrome (ARDS) (95%CI 13.7–51.8), 6.2% (95%CI 3.1–9.3) with shock. Some 13.9% (95%CI 6.2–21.5%) of hospitalized patients had fatal outcomes (case fatality rate, CFR). Conclusion: COVID-19 brings a huge burden to healthcare facilities, especially in patients with comorbidities. ICU was required for approximately 20% of polymorbid, COVID-19 infected patients and hospitalization was associated with a CFR of >13%. As this virus spreads globally, countries need to urgently prepare human resources, infrastructure and facilities to treat severe COVID-19. © 2020 Elsevier Ltd",Clinical features; Coronavirus disease 2019; Epidemic; Laboratory; Outcomes; SARS-CoV-2,,"Bonilla-Aldana, D.K., Dhama, K., Rodriguez-Morales, A.J., Revisiting the one health approach in the context of COVID-19: a look into the ecology of this emerging disease (2020) Adv Anim Vet Sci, 8, pp. 234-237; Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., A novel coronavirus from patients with pneumonia in China (2019) N Engl J Med, , 2020; Chan, J.F.-W., Yuan, S., Kok, K.-H., To, K.K.-W., Chu, H., Yang, J., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet; Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506; The, L., Emerging understandings of 2019-nCoV (2020) Lancet, 395, p. 311; Bastola, A., Sah, R., Rodriguez-Morales, A.J., Lal, B.K., Jha, R., Ojha, H.C., The first 2019 novel coronavirus case in Nepal (2020) Lancet Infect Dis, 20, pp. 279-280; Bonilla-Aldana, D.K., Villamil-Gómez, W.E., Rabaan, A.A., Rodriguez-Morales, A.J., Una nueva zoonosis viral de preocupación global: COVID-19, enfermedad por coronavirus 2019 (2020) Iatreia, p. 33; Millan-Oñate, J., Rodríguez-Morales, A.J., Camacho-Moreno, G., Mendoza-Ramírez, H., Rodríguez-Sabogal, I.A., Álvarez-Moreno, C., A new emerging zoonotic virus of concern: the 2019 novel Coronavirus (COVID-19) (2020) Infectio, p. 24; Ksiazek, T.G., Erdman, D., Goldsmith, C.S., Zaki, S.R., Peret, T., Emery, S., A novel coronavirus associated with severe acute respiratory syndrome (2003) N Engl J Med, 348, pp. 1953-1966; Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Early transmission dynamics in wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med; Phan, L.T., Nguyen, T.V., Luong, Q.C., Nguyen, T.V., Nguyen, H.T., Le, H.Q., Importation and human-to-human transmission of a novel coronavirus in vietnam (2020) N Engl J Med; Pongpirul, W.A., Pongpirul, K., Ratnarathon, A.C., Prasithsirikul, W., Journey of a Thai taxi driver and novel coronavirus (2020) N Engl J Med, 382 (11), pp. 1067-1068; Gorbalenya, A.E., Severe acute respiratory syndrome-related coronavirus – the species and its viruses, a statement of the Coronavirus Study Group (2020), bioRxiv 2020.02.07.937862; Drosten, C., Gunther, S., Preiser, W., van der Werf, S., Brodt, H.R., Becker, S., Identification of a novel coronavirus in patients with severe acute respiratory syndrome (2003) N Engl J Med, 348, pp. 1967-1976; Kuiken, T., Fouchier, R.A., Schutten, M., Rimmelzwaan, G.F., van Amerongen, G., van Riel, D., Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome (2003) Lancet, 362, pp. 263-270; de Wit, E., van Doremalen, N., Falzarano, D., Munster, V.J., SARS and MERS: recent insights into emerging coronaviruses (2016) Nat Rev Microbiol, 14, pp. 523-534; Al-Tawfiq, J.A., Gautret, P., Asymptomatic Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection: extent and implications for infection control: a systematic review (2019) Trav Med Infect Dis, 27, pp. 27-32; Baharoon, S., Memish, Z.A., MERS-CoV as an emerging respiratory illness: a review of prevention methods (2019) Trav Med Infect Dis; Bonilla-Aldana, D.K., Quintero-Rada, K., Montoya-Posada, J.P., Ramirez, S., Paniz-Mondolfi, A., Rabaan, A., SARS-CoV, MERS-CoV and now the 2019-novel CoV: have we investigated enough about coronaviruses? - a bibliometric analysis (2020) Trav Med Infect Dis; Al-Tawfiq, J.A., Zumla, A., Memish, Z.A., Travel implications of emerging coronaviruses: SARS and MERS-CoV (2014) Trav Med Infect Dis, 12, pp. 422-428; World Health Organization, Novel coronavirus (2019-nCoV) - situation report - 10 - 30 January 2020 https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200130-sitrep-10-ncov.pdf?sfvrsn=d0b2e480_2.2020; World Health Organization, Pneumonia of unknown cause – China https://www.who.int/csr/don/05-january-2020-pneumonia-of-unkown-cause-china/en/.2020; Rodriguez-Morales, A.J., Bonilla-Aldana, D.K., Balbin-Ramon, G.J., Paniz-Mondolfi, A., Rabaan, A., Sah, R., History is repeating itself, a probable zoonotic spillover as a cause of an epidemic: the case of 2019 novel Coronavirus (2020) Infez Med, 28, pp. 3-5; Bonilla-Aldana, D.K., Suarez, J.A., Franco-Paredes, C., Vilcarromero, S., Mattar, S., Gomez-Marin, J.E., Brazil burning! What is the potential impact of the Amazon wildfires on vector-borne and zoonotic emerging diseases? - a statement from an international experts meeting (2019) Trav Med Infect Dis, 31; Mattar, S., González, M., Zoonotic emergence of coronavirus: a potential public risk for Latin America (2018) Rev MVZ Cordoba, 23, pp. 6775-6777; Plowright, R.K., Parrish, C.R., McCallum, H., Hudson, P.J., Ko, A.I., Graham, A.L., Pathways to zoonotic spillover (2017) Nat Rev Microbiol, 15, pp. 502-510; Yin, Y., Wunderink, R.G., MERS, SARS and other coronaviruses as causes of pneumonia (2018) Respirology, 23, pp. 130-137; Holshue, M.L., DeBolt, C., Lindquist, S., Lofy, K.H., Wiesman, J., Bruce, H., First case of 2019 novel coronavirus in the United States (2020) N Engl J Med, 382 (10), pp. 929-936; Silverstein, W.K., Stroud, L., Cleghorn, G.E., Leis, J.A., First imported case of 2019 novel coronavirus in Canada, presenting as mild pneumonia (2020) Lancet, 95 (10225), p. 734; Cardona-Ospina, J.A., Henao-SanMartin, V., Acevedo-Mendoza, W.F., Nasner-Posso, K.M., Martinez-Pulgarin, D.F., Restrepo-Lopez, A., Fatal Zika virus infection in the Americas: a systematic review (2019) Int J Infect Dis, 88, pp. 49-59; Rodriguez-Morales, A.J., Cardona-Ospina, J.A., Fernanda Urbano-Garzon, S., Sebastian Hurtado-Zapata, J., Prevalence of post-chikungunya infection chronic inflammatory arthritis: a systematic review and meta-analysis (2016) Arthritis Care Res. 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Radiology; Chen, L., Liu, H.G., Liu, W., Liu, J., Liu, K., Shang, J., [Analysis of clinical features of 29 patients with 2019 novel coronavirus pneumonia] (2020) Zhonghua Jiehe He Huxi Zazhi, 43, p. 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China (2/10/2020). SSRN Preprints available at SSRN; Pan, F., Ye, T., Sun, P., Gui, S., Liang, B., Li, L., (2020), p. 200370. , Time course of lung changes on chest CT during recovery from 2019 novel coronavirus (COVID-19) pneumonia. Radiology; Feng, K., Yun, Y.X., Wang, X.F., Yang, G.D., Zheng, Y.J., Lin, C.M., [Analysis of CT features of 15 Children with 2019 novel coronavirus infection] (2020) Zhonghua Er Ke Za Zhi, 58, p. E007; Wang, X.F., Yuan, J., Zheng, Y.J., Chen, J., Bao, Y.M., Wang, Y.R., [Clinical and epidemiological characteristics of 34 children with 2019 novel coronavirus infection in Shenzhen] (2020) Zhonghua Er Ke Za Zhi, 58, p. E008","Rodriguez-Morales, A.J.; Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnológica de PereiraColombia; email: arodriguezm@utp.edu.co",,Elsevier USA,14778939,,TMIDA,32179124,English,Travel Med. Infect. Dis.,Review,Article in Press,Open Access,Scopus,2-s2.0-85082005057,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Parčina M., Schneider U.V., Visseaux B., Jozić R., Hannet I., Lisby J.G.",25646678900;14024963300;45961678400;57215700048;57210194151;6603004928;,Multicenter evaluation of the QIAstat Respiratory Panel—A new rapid highly multiplexed PCR based assay for diagnosis of acute respiratory tract infections,2020,PLoS ONE,15,3, e0230183,,,,,10.1371/journal.pone.0230183,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081673068&doi=10.1371%2fjournal.pone.0230183&partnerID=40&md5=4bce4728cf3183272427fe3b111971f4,"Institute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany; Department of Clinical Microbiology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark; IAME, UMR 1137, INSERM, Université Paris Diderot, Sorbonne Paris Cité, AP-HP, Laboratoire de Virologie, Hôpital Bichat, AP-HP, Paris, France; STAT-Dx Life (Qiagen) Parc Científic, Barcelona, Spain","Parčina, M., Institute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany; Schneider, U.V., Department of Clinical Microbiology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark; Visseaux, B., IAME, UMR 1137, INSERM, Université Paris Diderot, Sorbonne Paris Cité, AP-HP, Laboratoire de Virologie, Hôpital Bichat, AP-HP, Paris, France; Jozić, R., Institute of Medical Microbiology, Immunology and Parasitology, University Hospital Bonn, Bonn, Germany; Hannet, I., STAT-Dx Life (Qiagen) Parc Científic, Barcelona, Spain; Lisby, J.G., Department of Clinical Microbiology, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark","Acute respiratory tract infections (ARTI), including the common cold, pharyngitis, sinusitis, otitis media, bronchiolitis and pneumonia are the most common diagnoses among patients seeking medical care in western countries, and account for most antibiotic prescriptions. While a confirmed and fast ARTI diagnosis is key for antibiotic prescribing, empiric antimicrobial treatment remains common, because viral symptoms are often clinically similar and difficult to distinguish from those caused by bacteria. As a result, inappropriate antibiotic prescriptions are high and in certain settings likely higher than the commonly estimated 30%. The QIAstat Respiratory Panel® assay (QIAstat RP) is a multiplexed in vitro diagnostics test for the rapid simultaneous detection of 21 pathogens directly from respiratory samples, including human mastadenovirus A-G, primate bocaparvovirus 1+2, human coronavirus (HKU1, NL63, OC43, 229E), human metapneumovirus A/B, rhinovirus/enterovirus, influenza A virus (no subtype, subtype H1, H1N1/2009, H3), influenza B virus, human respirovirus 1+3, human orthorubulavirus 2+4, human orthopneumovirus, Bordetella pertussis, Chlamydia pneumoniae, Mycoplasma pneumoniae and Legionella pneumophila. We describe the first multicenter study of 445 respiratory samples, collected through the 2016–2017 and 2018 respiratory seasons, with performance compared against BioFire FilmArray RP v1.7 and discrepancy testing by Seegene Allplex RP. The QIAstat RP demonstrated a positive percentage of agreement of 98.0% (95% CI: 96.0–99.1%) and a negative percentage agreement of 99.8% (95% CI: 99.6–99.9%). With use of this comprehensive and rapid test, improved patient outcomes and antimicrobial stewardship may potentially be achieved. © 2020 Parčina et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",,adolescent; adult; antimicrobial stewardship; Article; bacterium identification; Bocaparvovirus; Bordetella pertussis; child; Chlamydia pneumoniae; clinical evaluation; controlled study; Coronavirus infection; diagnostic test; diagnostic value; false negative result; false positive result; female; human; Human adenovirus A; human coronavirus 2019; Human coronavirus 229E; Human coronavirus NL63; Human coronavirus OC43; in vitro study; Influenza A virus; Influenza B virus; Legionella pneumophila; major clinical study; male; Mastadenovirus; Mastadenovirus G; middle aged; mixed infection; multiplex polymerase chain reaction; Mycoplasma pneumoniae; nonhuman; observational study; Pneumovirus; prescription; primate; prospective study; respiratory tract infection; Respirovirus; Respirovirus 1; Respirovirus 3; retrospective study; sensitivity and specificity; virus identification,"Mortality, morbidity, and hospitalisations due to influenza lower respiratory tract infections, 2017: An analysis for the Global Burden of Disease Study 2017 (2019) Lancet Respir Med, 7, pp. 69-89. , https://doi.org/10.1016/S2213-2600(18)30496-X, PMID: 30553848; Brealey, J.C., Sly, P.D., Young, P.R., Chappell, K.J., Viral bacterial co-infection of the respiratory tract during early childhood (2015) FEMS Microbiol Lett, 362, pp. 1-11; Lambkin-Williams, R., Noulin, N., Mann, A., Catchpole, A., Gilbert, A.S., The human viral challenge model: Accelerating the evaluation of respiratory antivirals, vaccines and novel diagnostics (2018) Respir Res, 19, p. 123. , https://doi.org/10.1186/s12931-018-0784-1, PMID: 29929556; Fleming, D.M., Taylor, R.J., Lustig, R.L., Schuck-Paim, C., Haguinet, F., Webb, D.J., Modelling estimates of the burden of respiratory syncytial virus infection in adults and the elderly in the United Kingdom (2015) BMC Infect Dis, 15, p. 443. , https://doi.org/10.1186/s12879-015-1218-z, PMID: 26497750; 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Voiriot, G., Visseaux, B., Cohen, J., Nguyen, L.B.L., Neuville, M., Morbieu, C., Viral-bacterial coinfection affects the presentation and alters the prognosis of severe community-acquired pneumonia (2016) Crit Care, 20, p. 375. , https://doi.org/10.1186/s13054-016-1517-9, PMID: 27852281; (2018) Prevention Strategies for Seasonal Influenza in Healthcare Settings, , https://www.cdc.gov/flu/professionals/infectioncontrol/healthcaresettings.htm; Li, J., Song, X., Yang, T., Chen, Y., Gong, Y., Yin, X., Systematic review of antibiotic prescription associated with upper respiratory tract infections in China (2016) Med (United States), 95; Fleming-Dutra, K.E., Hersh, A.L., Shapiro, D.J., Bartoces, M., Enns, E.A., File, T.M., Prevalence of inappropriate antibiotic prescriptions among US ambulatory care visits, 2010–2011 (2016) JAMA—J Am Med Assoc, 315, pp. 1864-1873; Schreckenberger, P.C., McAdam, A.J., Point-counterpoint: Large multiplex PCR panels should be first-line tests for detection of respiratory and intestinal pathogens (2015) J Clin Microbiol, 53, pp. 3110-3115. , https://doi.org/10.1128/JCM.00382-15, PMID: 25762770; Hansen, G.T., Moore, J., Herding, E., Gooch, T., Hirigoyen, D., Hanson, K., Clinical decision making in the emergency department setting using rapid PCR: Results of the CLADE study group (2018) J Clin Virol, 102, pp. 42-49. , https://doi.org/10.1016/j.jcv.2018.02.013, PMID: 29494950; Brendish, N.J., Malachira, A.K., Armstrong, L., Houghton, R., Aitken, S., Nyimbili, E., Routine molecular point-of-care testing for respiratory viruses in adults presenting to hospital with acute respiratory illness (ResPOC): A pragmatic, open-label, randomised controlled trial (2017) Lancet Respir Med, 5, pp. 401-411. , https://doi.org/10.1016/S2213-2600(17)30120-0, PMID: 28392237; Rappo, U., Schuetz, A.N., Jenkins, S.G., Calfee, D.P., Walsh, T.J., Wells, M.T., Impact of early detection of respiratory viruses by multiplex PCR assay on clinical outcomes in adult patients (2016) J Clin Microbiol, 54, pp. 2096-2103. , https://doi.org/10.1128/JCM.00549-16, PMID: 27225406; Rogers, B.B., Shankar, P., Jerris, R.C., Kotzbauer, D., Anderson, E.J., Watson, J.R., Impact of a rapid respiratory panel test on patient outcomes (2015) Arch Pathol Lab Med, 139, pp. 636-641. , https://doi.org/10.5858/arpa.2014-0257-OA, PMID: 25152311; Brendish, N.J., Malachira, A.K., Beard, K.R., Ewings, S., Clark, T.W., Impact of turnaround time on outcome with point-of-care testing for respiratory viruses: A post hoc analysis from a randomised controlled trial (2018) Eur Respir J, 52, p. 1800555. , https://doi.org/10.1183/13993003.00555-2018, PMID: 29946003; Landes, M.B., Neil, R.B., McCool, S.S., Mason, B.P., Woron, A.M., Garman, R.L., The frequency and seasonality of influenza and other respiratory viruses in Tennessee: Two influenza seasons of surveillance data, 2010–2012 (2013) Influenza Other Respi Viruses, 7, pp. 1122-1127; Marinović, A.B., Swaan, C., van Steenbergen, J., Kretzschmar, M., Quantifying reporting timeliness to improve outbreak control (2015) Emerg Infect Dis, 21, pp. 209-216. , https://doi.org/10.3201/eid2102.130504, PMID: 25625374; Uyeki, T.M., Bernstein, H.H., Bradley, J.S., Englund, J.A., File, T.M., Fry, A.M., Clinical practice guidelines by the infectious diseases society of America: 2018 update on diagnosis, treatment, chemoprophylaxis, and institutional outbreak management of seasonal influenza (2018) Clin Infect Dis, , https://doi.org/10.1093/cid/ciy866, PMID: 30566567; Trabattoni, E., Le, V., Pilmis, B., Pean de Ponfilly, G., Caisso, C., Couzigou, C., Implementation of Alere i influenza A & B point of care test for the diagnosis of influenza in an ED (2018) Am J Emerg Med, 36, pp. 916-921. , https://doi.org/10.1016/j.ajem.2017.10.046, PMID: 29137903","Schneider, U.V.; Department of Clinical Microbiology, Copenhagen University Hospital HvidovreDenmark; email: uffe.vest.schneider@regionh.dk",,Public Library of Science,19326203,,POLNC,32163484,English,PLoS ONE,Article,Final,Open Access,Scopus,2-s2.0-85081673068,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Altamimi A., Abu-Saris R., El-Metwally A., Alaifan T., Alamri A.",57211564261;6602877125;6602087856;57215130981;57216013068;,Demographic Variations of MERS-CoV Infection among Suspected and Confirmed Cases: An Epidemiological Analysis of Laboratory-Based Data from Riyadh Regional Laboratory,2020,BioMed Research International,2020,,9629747,,,,,10.1155/2020/9629747,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080993454&doi=10.1155%2f2020%2f9629747&partnerID=40&md5=855e4a0d8c8cf71999422a754263fe6f,"College of Public Health and Health Informatics, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; National Health Laboratory, Saudi Center for Disease Prevention and Control (Saudi CDC), Riyadh, Saudi Arabia; King Abdullah International Medical Research Center (KAIMARC), Riyadh, Saudi Arabia; Department of Virology and Cytogenetics, Riyadh Regional Laboratory, Riyadh, Saudi Arabia","Altamimi, A., College of Public Health and Health Informatics, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia, National Health Laboratory, Saudi Center for Disease Prevention and Control (Saudi CDC), Riyadh, Saudi Arabia; Abu-Saris, R., College of Public Health and Health Informatics, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia, King Abdullah International Medical Research Center (KAIMARC), Riyadh, Saudi Arabia; El-Metwally, A., College of Public Health and Health Informatics, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia, King Abdullah International Medical Research Center (KAIMARC), Riyadh, Saudi Arabia; Alaifan, T., National Health Laboratory, Saudi Center for Disease Prevention and Control (Saudi CDC), Riyadh, Saudi Arabia; Alamri, A., Department of Virology and Cytogenetics, Riyadh Regional Laboratory, Riyadh, Saudi Arabia","Introduction. Middle East respiratory syndrome coronavirus was first recognized in September 2012 in Saudi Arabia. The clinical presentations of MERS and non-MERS SARI are often similar. Therefore, the identification of suspected cases that may have higher chances of being diagnosed as cases of MERS-CoV is essential. However, the real challenge is to flag these patients through some demographic markers. The nature of these markers has not previously been investigated in Saudi Arabia, and hence, this study aims to identify them. Methods. It was a surveillance system-based study, for which data from a total of 23,646 suspected patients in Riyadh and Al Qassim regions were analyzed from January 2017 until December 2017 to estimate the prevalence of MERS-CoV among suspected cases and to determine potential demographic risk factors related to the confirmation of the diagnosis. Results. Of 23,646 suspected cases, 119 (0.5%) were confirmed by laboratory results. These confirmed cases (67.2% of which were males) had a mean age of 43.23 years (SD ± 22.8). Around 42.2% of the confirmed cases were aged between 41 and 60 years and about 47% of confirmed cases had their suspected specimen tested in the summer. The study identified three significant and independent predictors for confirmation of the disease: an age between 41 and 60 years, male gender, and summer season admission. Conclusion. The study provides evidence that the MERS-CoV epidemic in the subject regions has specific characteristics that might help future plans for the prevention and management of such a contagious disease. Future studies should aim to confirm such findings in other regions of Saudi Arabia as well and explore potential preventable risk factors. © 2020 Asmaa Altamimi et al.",,adult; Article; cross-sectional study; demography; disease surveillance; female; groups by age; health care personnel; human; laboratory test; major clinical study; male; Middle East respiratory syndrome; prevalence; risk factor; Saudi Arabia; seasonal variation; sex difference; spring; summer,"Zaki, A.M., Van Boheemen, S., Bestebroer, T.M., Osterhaus, A.D.M.E., Fouchier, R.A.M., Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia (2012) New England Journal of Medicine, 367 (19), pp. 1814-1820. , 2-s2.0-84868516062; Who, (2019) Middle East Respiratory Syndrome Coronavirus (MERS-CoV), , Geneva, Switzerland WHO https://www.who.int/news-room/fact-sheets/detail/middle-east-respiratory-syndrome-coronavirus-(mers-cov); Who, (2019) MERS Situation Update, , Geneva, Switzerland WHO http://applications.emro.who.int/docs/EMROPub_2019_EN_22346.pdf?ua=1&ua=1; For Disease Control And Prevention, C., (2015) Middle East Respiratory Syndrome (MERS), , Geneva, Switzerland WHO http://www.cdc.gov/features/novelcoronavirus/; Centre For Disease Prevention And Control, E., (2015) Communicable Disease Threats Report, , Solna Municipality, Sweden ECDC https://ecdc.europa.eu/en/publications/Publications/communicable-disease-threats-report-14-nov-2015.pdf; Who, (2015) MERS-CoV Outbreak Largest Outside Kingdom of Saudi Arabia, , Geneva, Switzerland WHO http://www.who.int/mediacentre/news/mers/briefing-notes/2-june-2015-republic-of-korea/en/; Thabet, F., Chehab, M., Bafaqih, H., Almohaimeed, S., Middle East respiratory syndrome coronavirus in children (2015) Saudi Medical Journal, 36 (4), pp. 484-486. , 2-s2.0-84926387921; Assiri, A., McGeer, A., Perl, T.M., Hospital outbreak of Middle East respiratory syndrome coronavirus (2013) New England Journal of Medicine, 369 (5), pp. 407-416. , 2-s2.0-84880088201; Arabi, Y.M., Arifi, A.A., Balkhy, H.H., Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection (2014) Annals of Internal Medicine, 160 (6), pp. 389-397; Alghamdi, I., Hussain, I., Alghamdi, M., Almalki, S., Alghamdi, M., Elsheemy, M., The pattern of Middle East respiratory syndrome coronavirus in Saudi Arabia: A descriptive epidemiological analysis of data from the Saudi Ministry of Health (2014) International Journal of General Medicine, 7, p. 417. , 2-s2.0-84907331491; Memish, Z.A., Zumla, A.I., Al-Hakeem, R.F., Al-Rabeeah, A.A., Stephens, G.M., Family cluster of Middle East respiratory syndrome coronavirus infections (2013) New England Journal of Medicine, 368 (26), pp. 2487-2494. , 2-s2.0-84879055980; Omrani, A.S., Al-Tawfiq, J.A., Memish, Z.A., Middle East respiratory syndrome coronavirus (MERS-CoV): Animal to human interaction (2015) Pathogens and Global Health, 109 (8), pp. 354-362. , 2-s2.0-84959367102; Assiri, A., Al-Tawfiq, J.A., Al-Rabeeah, A.A., Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: A descriptive study (2013) The Lancet Infectious Diseases, 13 (9), pp. 752-761. , 2-s2.0-84882598788; Aly, M., Elrobh, M., Alzayer, M., Aljuhani, S., Balkhy, H., Occurrence of the Middle East respiratory syndrome coronavirus (MERS-CoV) across the gulf corporation council countries: Four years update (2017) PloS One, 12 (10). , e0183850 2-s2.0-85031280310; Qattan, I., Aljohani, A., Alfarsi, M., Aljohani, E., Alsubhi, M., Mers-Cov, An epidemic whirlwind (2016) Biology Medicine, 8 (4), p. 1; Arabi, Y.M., Al-Omari, A., Mandourah, Y., Critically ill patients with the Middle East respiratory syndrome (2017) Critical Care Medicine, 45 (10), pp. 1683-1695. , 2-s2.0-85030424755; Al-Tawfiq, J.A., Hinedi, K., Ghandour, J., Middle East respiratory syndrome coronavirus: A case-control study of hospitalized patients (2014) Clinical Infectious Diseases, 59 (2), pp. 160-165. , 2-s2.0-84901755321; Mohd, H.A., Memish, Z.A., Alfaraj, S.H., Predictors of MERS-CoV infection: A large case control study of patients presenting with ILI at a MERS-CoV referral hospital in Saudi Arabia (2016) Travel Medicine and Infectious Disease, 14 (5), pp. 464-470. , 2-s2.0-84991825012; Garbati, M.A., Fagbo, S.F., Fang, V.J., A comparative study of clinical presentation and risk factors for adverse outcome in patients hospitalised with acute respiratory disease due to MERS coronavirus or other causes (2016) PloS One, 11 (11). , e0165978 2-s2.0-84994236032; https://www.moh.gov.sa/CCC/healthp/regulations/Documents/MERS-CoV, Infection Prevention and Control Guidelines for Middle; Ahmed, A.E., Alshukairi, A.N., Al-Jahdali, H., Development of a risk-prediction model for Middle East respiratory syndrome coronavirus infection in dialysis patients (2018) Hemodialysis International, 22 (4), pp. 474-479. , 2-s2.0-85045386656; Al Johani, S., Hajeer, A.H., MERS-CoV diagnosis: An update (2016) Journal of Infection and Public Health, 9 (3), pp. 216-219. , 2-s2.0-84963958124; Da'Ar, O.B., Ahmed, A.E., Underlying trend, seasonality, prediction, forecasting and the contribution of risk factors: An analysis of globally reported cases of Middle East Respiratory Syndrome Coronavirus (2018) Epidemiology and Infection, 146 (11), pp. 1343-1349. , 2-s2.0-85048306956; Faridi, U., Middle East respiratory syndrome coronavirus (MERS-CoV): Impact on Saudi Arabia, 2015 (2018) Saudi Journal of Biological Sciences, 25 (7), pp. 1402-1405. , 2-s2.0-85002374695; https://seer.cancer.gov/stdpopulations/world.who.html, World (WHO 2000-2025) Standard - Standard Populations - SEER Datasets [Internet], Acute Myeloid Leukemia - Cancer Stat Facts; Fagbo, S.F., Garbati, M.A., Hasan, R., Acute viral respiratory infections among children in MERS-endemic Riyadh, Saudi Arabia, 2012-2013 (2017) Journal of Medical Virology, 89 (2), pp. 195-201. , 2-s2.0-84989266731; Ahmed, A.E., Estimating survival rates in MERS-CoV patients 14 and 45 days after experiencing symptoms and determining the differences in survival rates by demographic data, disease characteristics and regions: A worldwide study (2018) Epidemiology and Infection, 146 (4), pp. 489-495. , 2-s2.0-85042208308; Ahmed, A.E., Diagnostic delays in 537 symptomatic cases of Middle East respiratory syndrome coronavirus infection in Saudi Arabia (2017) International Journal of Infectious Diseases, 62, pp. 47-51. , 2-s2.0-85026639674; Ahmed, A.E., The predictors of 3-and 30-day mortality in 660 MERS-CoV patients (2017) BMC Infectious Diseases, 17 (1), p. 615. , 2-s2.0-85029234677; Alraddadi, B.M., Al-Salmi, H.S., Jacobs-Slifka, K., Risk factors for Middle East respiratory syndrome coronavirus infection among healthcare personnel (2016) Emerging Infectious Diseases, 22 (11), pp. 1915-1920. , 2-s2.0-84992161353; Mohamed, D.H., Alhetheel, A.F., Mohamud, H.S., Aldosari, K., Alzamil, F.A., Somily, A.M., Clinical validation of 3 commercial real-time reverse transcriptase polymerase chain reaction assays for the detection of Middle East respiratory syndrome coronavirus from upper respiratory tract specimens (2017) Diagnostic Microbiology and Infectious Disease, 87 (4), pp. 320-324. , 2-s2.0-85013158213","Altamimi, A.; College of Public Health and Health Informatics, King Saud Bin Abdulaziz University for Health SciencesSaudi Arabia; email: altamimi.asmaa@outlook.com",,Hindawi Limited,23146133,,,32149148,English,BioMed Res. Int.,Article,Final,Open Access,Scopus,2-s2.0-85080993454,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Satia I., Cusack R., Greene J.M., O'Byrne P.M., Killian K.J., Johnston N.",40661860900;57215737133;7402744396;7102156248;56186302600;7102687120;,"Prevalence and contribution of respiratory viruses in the community to rates of emergency department visits and hospitalizations with respiratory tract infections, chronic obstructive pulmonary disease and asthma",2020,PLoS ONE,15,2, e0228544,,,,,10.1371/journal.pone.0228544,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079083926&doi=10.1371%2fjournal.pone.0228544&partnerID=40&md5=457104e5b1a11105b399116ec083c924,"Firestone Institute for Respiratory Health, St Joseph's Healthcare, Hamilton, Canada; University of Manchester, Division of Infection, Immunity and Respiratory Medicine, Manchester Academic, Health Science Centre, Manchester, United Kingdom; McMaster University, Department of Medicine, Hamilton, Canada","Satia, I., Firestone Institute for Respiratory Health, St Joseph's Healthcare, Hamilton, Canada, University of Manchester, Division of Infection, Immunity and Respiratory Medicine, Manchester Academic, Health Science Centre, Manchester, United Kingdom; Cusack, R., Firestone Institute for Respiratory Health, St Joseph's Healthcare, Hamilton, Canada, McMaster University, Department of Medicine, Hamilton, Canada; Greene, J.M., McMaster University, Department of Medicine, Hamilton, Canada; O'Byrne, P.M., Firestone Institute for Respiratory Health, St Joseph's Healthcare, Hamilton, Canada, McMaster University, Department of Medicine, Hamilton, Canada; Killian, K.J., McMaster University, Department of Medicine, Hamilton, Canada; Johnston, N., Firestone Institute for Respiratory Health, St Joseph's Healthcare, Hamilton, Canada","Background: The individual and combined contribution of viral prevalence in the community to Emergency Department (ED) visits and hospitalizations with respiratory tract infections (RTIs), chronic obstructive pulmonary disease (COPD) and asthma is unclear. Methods: A retrospective analysis on daily viral positive tests and daily ED visits and hospitalizations between 01/01/2003 to 31/12/2013 in Ontario, Canada. Viral data was collected from the Centre for Immunization and Respiratory Infectious Diseases (CIRID). The Canadian Institute for Health Information reports daily ED visits and hospitalizations for RTIs, COPD and asthma as a primary diagnosis. Results: There were 4,365,578 ED visits with RTIs of which 321,719 (7.4%) were admitted to hospital; 817,141 ED visits for COPD of which 260,665 (31.9%) were admitted and 649,666 ED visits with asthma of which 68,626 (10.6%) were admitted. The percentage of positive tests to influenza A and B, respiratory syncytial virus (RSV), parainfluenza and adenovirus prevalence explained 57.4% of ED visits and 63.8% of hospitalizations for RTI, 41.4% of ED visits and 39.2% of hospitalizations with COPD but only 1.5% of ED visits and 2.7% of hospitalizations for asthma. The further addition of human metapneumovirus, rhinovirus and coronavirus over the final 3 years accounted for 66.7% of ED visits and 74.4% of hospitalizations for RTI, 52.5% of visits and 48.2% of hospitalizations for COPD, and only 13.3% of visits and 10.4% of hospitalizations for asthma. Conclusions:Community respiratory viral epidemics are major drivers of ED visits and hospitalizations with RTIs and COPD but only a modest contributor to asthma. © 2020 Satia et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",,Adenoviridae; Article; asthma; Canada; chronic obstructive lung disease; community acquired infection; Coronavirinae; disease surveillance; emergency ward; epidemic; high risk population; hospitalization; human; Human metapneumovirus; Human respiratory syncytial virus; infection rate; Influenza A virus; Influenza B virus; major clinical study; nonhuman; Paramyxovirinae; population research; prevalence; respiratory tract infection; respiratory virus; retrospective study; Rhinovirus; seasonal variation; trend study; virus detection,"Beckham, J.D., Cadena, A., Lin, J., Piedra, P.A., Glezen, W.P., Greenberg, S.B., Respiratory viral infections in patients with chronic, obstructive pulmonary disease (2005) J Infect, 50 (4), pp. 322-330. , https://doi.org/10.1016/j.jinf.2004.07.011, PMID: 15845430; Busse, W.W., Lemanske, R.F., Jr., Gern, J.E., Role of viral respiratory infections in asthma and asthma exacerbations (2010) Lancet, 376 (9743), pp. 826-834. , https://doi.org/10.1016/S0140-6736(10)61380-3, PMID: 20816549; PubMed Central PMCID: PMC2972660; Ritchie, A.I., Farne, H.A., Singanayagam, A., Jackson, D.J., Mallia, P., Johnston, S.L., Pathogenesis of viral infection in exacerbations of airway disease (2015) Ann Am Thorac Soc, 12, pp. S115-S132. , https://doi.org/10.1513/AnnalsATS.201503-151AW, PMID: 26595727; Thompson, W.W., Shay, D.K., Weintraub, E., Brammer, L., Cox, N., Anderson, L.J., Mortality associated with influenza and respiratory syncytial virus in the United States (2003) Jama, 289 (2), pp. 179-186. , https://doi.org/10.1001/jama.289.2.179, PMID: 12517228; Hardelid, P., Pebody, R., Andrews, N., Mortality caused by influenza and respiratory syncytial virus by age group in England and Wales 1999-2010 (2013) Influenza and Other Respiratory Viruses, 7 (1), pp. 35-45. , https://doi.org/10.1111/j.1750-2659.2012.00345.x, PMID: 22405488; van Asten, L., van den Wijngaard, C., van Pelt, W., van de Kassteele, J., Meijer, A., van der Hoek, W., Mortality attributable to 9 common infections: Significant effect of influenza A, respiratory syncytial virus, influenza B, norovirus, and parainfluenza in elderly persons (2012) The Journal of Infectious Diseases, 206 (5), pp. 628-639. , https://doi.org/10.1093/infdis/jis415, PMID: 22723641; Byington, C.L., Wilkes, J., Korgenski, K., Sheng, X., Respiratory syncytial virus-associated mortality in hospitalized infants and young children (2015) Pediatrics, 135 (1), pp. e24-e31. , https://doi.org/10.1542/peds.2014-2151, PMID: 25489019; Nair, H., Nokes, D.J., Gessner, B.D., Dherani, M., Madhi, S.A., Singleton, R.J., Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: A systematic review and meta-analysis (2010) The Lancet, 375 (9725), pp. 1545-1555; Mallia, P., Johnston, S.L., Mechanisms and experimental models of chronic obstructive pulmonary disease exacerbations (2005) Proc Am Thorac Soc, 2 (4), pp. 361-366. , https://doi.org/10.1513/pats.200504-025SR, discussion 71-2. 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Data on seasonality of deaths due to asthma were omitted from paper but editorial's author did not know (1997) BMJ: British Medical Journal, 315 (7114), p. 1012; Lee, W.-M., Lemanske, R.F., Jr., Evans, M.D., Vang, F., Pappas, T., Gangnon, R., Human rhinovirus species and season of infection determine illness severity (2012) American Journal of Respiratory and Critical Care Medicine, 186 (9), pp. 886-891. , https://doi.org/10.1164/rccm.201202-0330OC, PMID: 22923659; The Ontario Asthma Surveillance Information System (OASIS), , https://lab.research.sickkids.ca/oasis/wp-content/uploads/sites/6/2018/07/prevrt_upto2016.pdf, 18th July 2019; (2018) Report from the Canadian Chronic Disease Surveillance System, , https://www.canada.ca/en/public-health/services/publications/diseases-conditions/asthma-chronic-obstructive-pulmonary-disease-canada-2018.html#a1.2.1, Canada","Satia, I.; Firestone Institute for Respiratory Health, St Joseph's HealthcareCanada; email: satiai@mcmaster.ca",,Public Library of Science,19326203,,POLNC,32027687,English,PLoS ONE,Article,Final,Open Access,Scopus,2-s2.0-85079083926,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Ryu J.-H., Shin S.-U., Choi K.-S.",57201116268;56967385500;7403949556;,Molecular surveillance of viral pathogens associated with diarrhea in pre-weaned Korean native calves,2020,Tropical Animal Health and Production,,,,,,,,10.1007/s11250-019-02181-w,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077676763&doi=10.1007%2fs11250-019-02181-w&partnerID=40&md5=4c1a8a83de914a1af4ee37dec996837f,"Department of Animal Science and Biotechnology, College of Ecology and Environmental Science, Kyungpook National University, Sangju, 37224, South Korea; Foreign Animal Disease Division, Animal and Plant Quarantine Agency, Gimcheon, 39660, South Korea","Ryu, J.-H., Department of Animal Science and Biotechnology, College of Ecology and Environmental Science, Kyungpook National University, Sangju, 37224, South Korea, Foreign Animal Disease Division, Animal and Plant Quarantine Agency, Gimcheon, 39660, South Korea; Shin, S.-U., Department of Animal Science and Biotechnology, College of Ecology and Environmental Science, Kyungpook National University, Sangju, 37224, South Korea; Choi, K.-S., Department of Animal Science and Biotechnology, College of Ecology and Environmental Science, Kyungpook National University, Sangju, 37224, South Korea","Calf diarrhea causes severe economic losses in the cattle industry worldwide. This study investigated the prevalence of bovine coronavirus (BCoV), bovine norovirus (BNoV), bovine group A rotavirus (BoRVA), and bovine torovirus (BToV) in calves aged ≤ 60 days, regardless of diarrhea, across nine different regions in the Republic of Korea (ROK) and reported associations between these viruses and diarrhea. Fecal samples were collected rectally from 689 calves: normal (n = 360) and diarrheic (n = 329). BNoV (84/689, 12.2%) was the most prevalent regardless of diarrhea, followed by BCoV (37/689, 5.4%), BToV (15/689, 2.2%), and BoRVA (13/689, 1.9%). Although BCoV (P = 0.032) and BoRVA (P = 0.007) were significantly associated with diarrhea in pre-weaned calves, BNoV and BToV showed no association. Infection by the four pathogens had no relationship with calf age; BoRVA was detected only in calves aged < 30 days, but this finding was not statistically significant. Phylogenetic analysis revealed that BCoV isolates obtained in this study were distinct from the other known BCoVs, and all BNoV isolates belonged to GIII.2 genotype; genetic variations in BNoVs are present in the ROK. BoRVA isolates distributed in the ROK were assigned to G6P[5]. Within the P[5] genotype, our isolates were divided into two lineages: P[5]-III and P[5]-VIII. P[5]- VIII lineage was dominant in pre-weaned Korean native calves. Our BToV isolates were more closely related to a European isolate, B145, than to Japanese isolates. Here, BNoV was frequently identified in calves, suggesting its non-significant contribution to calf diarrhea, whereas BCoV and BoRVA were responsible for calf diarrhea in the ROK. 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Anim. Health Prod.,Article,Article in Press,Open Access,Scopus,2-s2.0-85077676763,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Awaidy S.A., Al Hashami H.",36132809700;56369495900;,"Zoonotic Diseases in Oman: Successes, Challenges, and Future Directions",2020,Vector-Borne and Zoonotic Diseases,20,1,,1,9,,,10.1089/vbz.2019.2458,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077670253&doi=10.1089%2fvbz.2019.2458&partnerID=40&md5=3c664713281ce168258ef9823a58a38b,"Office of Health Affairs, Ministry of Health, Muscat, 393 PC 100, Oman; Pediatric Infectious Diseases, Royal Hospital, Muscat, Oman","Awaidy, S.A., Office of Health Affairs, Ministry of Health, Muscat, 393 PC 100, Oman; Al Hashami, H., Pediatric Infectious Diseases, Royal Hospital, Muscat, Oman","Objective: This article describes the situation analysis of endemic and emerging zoonoses, and includes prevention and control of zoonoses in Oman. It also suggests possible recommendations toward elimination and risk reduction of emerging zoonoses. Methods: Epidemiologic information has been drawn from official to assess the situation. There has been significant progress in reducing the risk of brucellosis, Middle East Respiratory Syndrome Coronavirus, Crimean-Congo hemorrhagic fever, and cutaneous leishmaniasis. Rabies, West Nile fever, Q fever, and cystic hydatid disease have been confined to wildlife or livestock. Results: There is an increasing threat of emerging and re-emerging zoonoses in Oman due to globalization of travel and trade, development activities, and impact of climate change and vector bionomics. Prevention, control, and subsequent elimination of zoonoses on a sustainable basis shall not be possible without intersectoral collaboration between the human and animal health sectors. There are challenges for establishing such strong collaboration and coordination mechanisms in Oman. Institutional and cultural barriers, data and resource sharing, and national capability for rapid and effective investigation of zoonotic infections and emerging zoonoses in humans and animal reservoirs are among others. Conclusions: In the light of achievements made on the prevention and control of zoonoses in Oman during the past decades, priority zoonoses should be identified for elimination, and continuous efforts should be made to further strengthen a holistic multidisciplinary and multisectorial approach for controlling zoonoses at source. 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Centers for Disease Control and Prevention. 2018","Awaidy, S.A.; Office of Health Affairs, Ministry of HealthOman; email: salah.awaidy@gmail.com",,Mary Ann Liebert Inc.,15303667,,VZDEB,31486732,English,Vector Borne Zoonotic Dis.,Review,Final,,Scopus,2-s2.0-85077670253,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Leist S.R., Cockrell A.S.",55846755300;57170359900;,Genetically engineering a susceptible mouse model for MERS-CoV-induced acute respiratory distress syndrome,2020,Methods in Molecular Biology,2099,,,137,159,,2,10.1007/978-1-0716-0211-9_12,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077343901&doi=10.1007%2f978-1-0716-0211-9_12&partnerID=40&md5=3ee664d7d31938d674eb5fc20601c4ea,"Department of Epidemiology, University of North Carolina-Chapel Hill, Chapel Hill, NC, United States; Durham, NC, United States","Leist, S.R., Department of Epidemiology, University of North Carolina-Chapel Hill, Chapel Hill, NC, United States; Cockrell, A.S., Durham, NC, United States","Since 2012, monthly cases of Middle East respiratory syndrome coronavirus (MERS-CoV) continue to cause severe respiratory disease that is fatal in ~35% of diagnosed individuals. The ongoing threat to global public health and the need for novel therapeutic countermeasures have driven the development of animal models that can reproducibly replicate the pathology associated with MERS-CoV in human infections. The inability of MERS-CoV to replicate in the respiratory tracts of mice, hamsters, and ferrets stymied initial attempts to generate small animal models. Identification of human dipeptidyl peptidase IV (hDPP4) as the receptor for MERS-CoV infection opened the door for genetic engineering of mice. Precise molecular engineering of mouse DPP4 (mDPP4) with clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 technology maintained inherent expression profiles, and limited MERS-CoV susceptibility to tissues that naturally express mDPP4, notably the lower respiratory tract wherein MERS-CoV elicits severe pulmonary pathology. Here, we describe the generation of the 288–330+/+ MERS-CoV mouse model in which mice were made susceptible to MERS-CoV by modifying two amino acids on mDPP4 (A288 and T330), and the use of adaptive evolution to generate novel MERS-CoV isolates that cause fatal respiratory disease. The 288–330+/+ mice are currently being used to evaluate novel drug, antibody, and vaccine therapeutic countermeasures for MERS-CoV. 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email: adam.alphavirus@gmail.com",,Humana Press Inc.,10643745,,,31883094,English,Methods Mol. Biol.,Book Chapter,Final,Open Access,Scopus,2-s2.0-85077343901,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Young B.E., Ong S.W.X., Kalimuddin S., Low J.G., Tan S.Y., Loh J., Ng O.-T., Marimuthu K., Ang L.W., Mak T.M., Lau S.K., Anderson D.E., Chan K.S., Tan T.Y., Ng T.Y., Cui L., Said Z., Kurupatham L., Chen M.I.-C., Chan M., Vasoo S., Wang L.-F., Tan B.H., Lin R.T.P., Lee V.J.M., Leo Y.-S., Lye D.C.",50462822400;57201670058;35484514100;8538590800;57215585628;57214666030;57203665233;55533856400;56569264500;57215584812;55239452900;25631949200;57215577506;23475824500;55985268900;57215085853;57209028898;57215584376;57209815423;35775087500;57214288354;57215848601;56061612500;57214889705;57216110768;7004240142;14016391200;,Epidemiologic Features and Clinical Course of Patients Infected with SARS-CoV-2 in Singapore,2020,JAMA - Journal of the American Medical Association,,,,,,,11,10.1001/jama.2020.3204,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081214652&doi=10.1001%2fjama.2020.3204&partnerID=40&md5=966620e5f9a2a376caeb447599e98da5,"National Centre for Infectious Diseases, Singapore, Singapore; Tan Tock Seng Hospital, Singapore, Singapore; Lee Kong Chian School of Medicine, Singapore, Singapore; Singapore General Hospital, Singapore, Singapore; Duke-NUS Graduate Medical School, Singapore, Singapore; Duke-NUS Medical School, Singapore, Singapore; Changi General Hospital, Singapore, Singapore; Sengkang General Hospital, Singapore, Singapore; Yong Loo Lin School of Medicine, Singapore, Singapore; DSO National Laboratories, Singapore, Singapore; Ministry of Health, Singapore, Singapore; Saw Swee Hock School of Public Health, Singapore, Singapore","Young, B.E., National Centre for Infectious Diseases, Singapore, Singapore, Tan Tock Seng Hospital, Singapore, Singapore, Lee Kong Chian School of Medicine, Singapore, Singapore; Ong, S.W.X., National Centre for Infectious Diseases, Singapore, Singapore, Tan Tock Seng Hospital, Singapore, Singapore; Kalimuddin, S., Singapore General Hospital, Singapore, Singapore, Duke-NUS Graduate Medical School, Singapore, Singapore; Low, J.G., Singapore General Hospital, Singapore, Singapore, Duke-NUS Medical School, Singapore, Singapore; Tan, S.Y., Changi General Hospital, Singapore, Singapore; Loh, J., Sengkang General Hospital, Singapore, Singapore; Ng, O.-T., National Centre for Infectious Diseases, Singapore, Singapore, Tan Tock Seng Hospital, Singapore, Singapore, Lee Kong Chian School of Medicine, Singapore, Singapore; Marimuthu, K., National Centre for Infectious Diseases, Singapore, Singapore, Tan Tock Seng Hospital, Singapore, Singapore, Yong Loo Lin School of Medicine, Singapore, Singapore; Ang, L.W., National Centre for Infectious Diseases, Singapore, Singapore; Mak, T.M., National Centre for Infectious Diseases, Singapore, Singapore; Lau, S.K., DSO National Laboratories, Singapore, Singapore; Anderson, D.E., Duke-NUS Medical School, Singapore, Singapore; Chan, K.S., Singapore General Hospital, Singapore, Singapore; Tan, T.Y., Duke-NUS Medical School, Singapore, Singapore, Changi General Hospital, Singapore, Singapore; Ng, T.Y., Sengkang General Hospital, Singapore, Singapore; Cui, L., National Centre for Infectious Diseases, Singapore, Singapore; Said, Z., Ministry of Health, Singapore, Singapore; Kurupatham, L., Ministry of Health, Singapore, Singapore; Chen, M.I.-C., National Centre for Infectious Diseases, Singapore, Singapore, Saw Swee Hock School of Public Health, Singapore, Singapore; Chan, M., National Centre for Infectious Diseases, Singapore, Singapore, Tan Tock Seng Hospital, Singapore, Singapore; Vasoo, S., National Centre for Infectious Diseases, Singapore, Singapore, Tan Tock Seng Hospital, Singapore, Singapore; Wang, L.-F., Duke-NUS Medical School, Singapore, Singapore; Tan, B.H., Lee Kong Chian School of Medicine, Singapore, Singapore, DSO National Laboratories, Singapore, Singapore; Lin, R.T.P., National Centre for Infectious Diseases, Singapore, Singapore; Lee, V.J.M., Ministry of Health, Singapore, Singapore, Saw Swee Hock School of Public Health, Singapore, Singapore; Leo, Y.-S., National Centre for Infectious Diseases, Singapore, Singapore, Tan Tock Seng Hospital, Singapore, Singapore, Lee Kong Chian School of Medicine, Singapore, Singapore, Yong Loo Lin School of Medicine, Singapore, Singapore, Saw Swee Hock School of Public Health, Singapore, Singapore; Lye, D.C., National Centre for Infectious Diseases, Singapore, Singapore, Tan Tock Seng Hospital, Singapore, Singapore, Lee Kong Chian School of Medicine, Singapore, Singapore, Yong Loo Lin School of Medicine, Singapore, Singapore","Importance: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China, in December 2019 and has spread globally with sustained human-to-human transmission outside China. Objective: To report the initial experience in Singapore with the epidemiologic investigation of this outbreak, clinical features, and management. Design, Setting, and Participants: Descriptive case series of the first 18 patients diagnosed with polymerase chain reaction (PCR)-confirmed SARS-CoV-2 infection at 4 hospitals in Singapore from January 23 to February 3, 2020; final follow-up date was February 25, 2020. Exposures: Confirmed SARS-CoV-2 infection. Main Outcomes and Measures: Clinical, laboratory, and radiologic data were collected, including PCR cycle threshold values from nasopharyngeal swabs and viral shedding in blood, urine, and stool. Clinical course was summarized, including requirement for supplemental oxygen and intensive care and use of empirical treatment with lopinavir-ritonavir. Results: Among the 18 hospitalized patients with PCR-confirmed SARS-CoV-2 infection (median age, 47 years; 9 [50%] women), clinical presentation was an upper respiratory tract infection in 12 (67%), and viral shedding from the nasopharynx was prolonged for 7 days or longer among 15 (83%). Six individuals (33%) required supplemental oxygen; of these, 2 required intensive care. There were no deaths. Virus was detectable in the stool (4/8 [50%]) and blood (1/12 [8%]) by PCR but not in urine. Five individuals requiring supplemental oxygen were treated with lopinavir-ritonavir. For 3 of the 5 patients, fever resolved and supplemental oxygen requirement was reduced within 3 days, whereas 2 deteriorated with progressive respiratory failure. Four of the 5 patients treated with lopinavir-ritonavir developed nausea, vomiting, and/or diarrhea, and 3 developed abnormal liver function test results. Conclusions and Relevance: Among the first 18 patients diagnosed with SARS-CoV-2 infection in Singapore, clinical presentation was frequently a mild respiratory tract infection. Some patients required supplemental oxygen and had variable clinical outcomes following treatment with an antiretroviral agent.. © 2020 The Author(s).",,,"Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395 (10223), pp. 497-506. , http://dx.doi.org/10.1016/S0140-6736(20)30183-5, 31986264; Lu, R., Zhao, X., Li, J., Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding (2020) Lancet, 395 (10224), pp. 565-574. , http://dx.doi.org/10.1016/S0140-6736(20)30251-8, PMID 32007145; Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382 (8), pp. 727-733. , http://dx.doi.org/10.1056/NEJMoa2001017, PMID 31978945; Wang, D., Hu, B., Hu, C., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China JAMA, , http://jamanetwork.com/article.aspx?doi=10.1001/jama.2020.1585, Published online February 7, 2020. doi: PMID 32031570; Wu, Z., McGoogan, J.M., Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a report of 72314 cases from the Chinese Center for Disease Control and Prevention JAMA, , http://jamanetwork.com/article.aspx?doi=10.1001/jama.2020.2648, Published online February 24, 2020. doi: PMID 32091533; Wong, J.E.L., Leo, Y.S., Tan, C.C., COVID-19 in Singapore - Current experience: Critical global issues that require attention and action JAMA, , http://jamanetwork.com/article.aspx?doi=10.1001/jama.2020.2467, Published online February 20, 2020. doi: PMID 32077901; Chan, K.S., Lai, S.T., Chu, C.M., Treatment of severe acute respiratory syndrome with lopinavir/ritonavir: A multicentre retrospective matched cohort study (2003) Hong Kong Med J, 9 (6), pp. 399-406. , PMID 14660806; Chu, C.M., Cheng, V.C., Hung, I.F., Role of lopinavir/ritonavir in the treatment of SARS: Initial virological and clinical findings (2004) Thorax, 59 (3), pp. 252-256. , http://dx.doi.org/10.1136/thorax.2003.012658, PMID 14985565; Chan, J.F., Yao, Y., Yeung, M.L., Treatment with lopinavir/ritonavir or interferon-β1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset (2015) J Infect Dis, 212 (12), pp. 1904-1913. , http://dx.doi.org/10.1093/infdis/jiv392, PMID 26198719; Sheahan, T.P., Sims, A.C., Leist, S.R., Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV (2020) Nat Commun, 11 (1), p. 222. , http://dx.doi.org/10.1038/s41467-019-13940-6, PMID 31924756; (2020), https://www.cdc.gov/coronavirus/2019-nCoV/hcp/infection-control.html, Interim infection prevention and control recommendations for patients with known or patients under investigation for 2019 novel coronavirus (2019-nCoV) in a healthcare setting. Centers for Disease Control and Prevention. Updated February 21, Accessed February 27, 2020; Lansbury, L.E., Rodrigo, C., Leonardi-Bee, J., Nguyen-Van-Tam, J., Shen Lim, W., Corticosteroids as adjunctive therapy in the treatment of influenza: An updated Cochrane systematic review and meta-analysis (2020) Crit Care Med, 48 (2), pp. e98-e106. , http://dx.doi.org/10.1097/CCM.0000000000004093, PMID 31939808; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study (2020) Lancet, 395 (10223), pp. 507-513. , http://dx.doi.org/10.1016/S0140-6736(20)30211-7, PMID 32007143; Chan, J.F., Yuan, S., Kok, K.H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: A study of a family cluster (2020) Lancet, 395 (10223), pp. 514-523. , http://dx.doi.org/10.1016/S0140-6736(20)30154-9, PMID 31986261; Peiris, J.S., Chu, C.M., Cheng, V.C., Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: A prospective study (2003) Lancet, 361 (9371), pp. 1767-1772. , http://dx.doi.org/10.1016/S0140-6736(03)13412-5, PMID 12781535; Oh, M.D., Park, W.B., Choe, P.G., Viral load kinetics of MERS coronavirus infection (2016) N Engl J Med, 375 (13), pp. 1303-1305. , http://dx.doi.org/10.1056/NEJMc1511695, PMID 27682053; Hung, I.F., Cheng, V.C., Wu, A.K., Viral loads in clinical specimens and SARS manifestations (2004) Emerg Infect Dis, 10 (9), pp. 1550-1557. , http://dx.doi.org/10.3201/eid1009.040058, PMID 15498155; Zou, L., Ruan, F., Huang, M., SARS-CoV-2 viral load in upper respiratory specimens of infected patients N Engl J Med, , http://dx.doi.org/10.1056/NEJMc2001737, Published online February 19, 2020. doi: PMID 32074444","Leo, Y.-S.; National Centre for Infectious Diseases, 16 Jln Tan Tock Seng, Singapore; email: Barnaby_young@ncid.sg",,American Medical Association,987484,,JAMAA,32125362,English,JAMA,Article,Article in Press,Open Access,Scopus,2-s2.0-85081214652,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zaher K.S., El-Dabae W.H., El-Sebelgy M.M., Aly N.I., Salama Z.T.",48161857300;57202857493;57215418563;57215436475;57215422960;,Genotyping and phylogenetic analysis of canine parvovirus circulating in Egypt,2020,Veterinary World,13,2,,326,333,,,10.14202/vetworld.2020.326-333,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080900379&doi=10.14202%2fvetworld.2020.326-333&partnerID=40&md5=b280a0ca5808f6c2e112fe8f30154f6e,"Department of Microbiology and Immunology, Veterinary Research Division, National Research Centre, Dokki, Giza, 12622, Egypt; Department of Pet Animal Vaccine Research, Veterinary Serum and Vaccine Research Institute, Abbasia, Egypt","Zaher, K.S., Department of Microbiology and Immunology, Veterinary Research Division, National Research Centre, Dokki, Giza, 12622, Egypt; El-Dabae, W.H., Department of Microbiology and Immunology, Veterinary Research Division, National Research Centre, Dokki, Giza, 12622, Egypt; El-Sebelgy, M.M., Department of Microbiology and Immunology, Veterinary Research Division, National Research Centre, Dokki, Giza, 12622, Egypt; Aly, N.I., Department of Pet Animal Vaccine Research, Veterinary Serum and Vaccine Research Institute, Abbasia, Egypt; Salama, Z.T., Department of Pet Animal Vaccine Research, Veterinary Serum and Vaccine Research Institute, Abbasia, Egypt","Aim: This study aimed to detect and characterize current genotypes of canine parvovirus (CPV) in Egypt during 2018. Materials and Methods: A total of 50 fecal swabs were collected from clinically infected domestic dogs of 2-5 months of age, suspected to suffer from CPV infection, from Cairo and Giza Governorates. The samples were subjected to qualitative antigen detection using the rapid test, followed by isolation on Madin-Darby Canine Kidney (MDCK) cells, molecular characterization with partial amplification of VP2 gene using polymerase chain reaction (PCR), followed by sequencing and phylogenetic analysis. Results: Out of 50 fecal samples, 20 samples were positive (40%) by Rapid CPV/canine coronavirus Ag Test Kit. These positive samples were cultured successfully on MDCK cells. Nine randomly chosen samples out of 30 apparently negative samples were amplified using PCR with primers Hfor and Hrev to yield a typical 630 bp fragment. Then, six randomly chosen samples out of nine were amplified using PCR with primers Pbs and Pbas to yield a typical 427 bp fragment. Sequencing, BLAST analysis and assembly of the two fragments (630 bp and 427 bp) to produce 912 bp fragments, in the six samples, revealed two serotypes CPV-2b and CPV-2c. The obtained strains were submitted to GenBank and given accession numbers MK642272, MK642273, MK642274, MK642275, MK642276, and MK642277. Phylogenetic analysis of the Egyptian strains serotype 2b illustrated that they were closely related to Thailand strains (accession numbers KP715709, KP715694, KP715701, and KP715700); while Egyptian strains serotype 2c was closely related to Thailand strains (accession numbers MH711894 and MH711902), Taiwanese strain (KU244254), Chinese strain (MF467242), and Vietnamese strain (accession number LC216910). Conclusion: The current research recommends further epidemiological studies to assess the extent of the occurrence of different serotypes of CPV in Egypt and the efficiency of imported and locally produced vaccines in protection against CPV infection. © Copyright: Zaher, et al. Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/)",Canine parvovirus; Egypt; Genotyping; Phylogenetic analysis; Serotyping,,"Ahmed, N., Riaz, A., Zubair, Z., Saqib, M., Ijaz, S., Nawaz-Ul-Rehman, M.S., Al-Qahtani, A., Mubin, M., Molecular analysis of partial VP-2 gene amplified from rectal swab samples of diarrheic dogs in Pakistan confirms the circulation of canine parvovirus genetic variant CPV-2a and detects sequences of feline panleukopenia virus (FPV) (2018) Virol. J., 15 (1), p. 45; Cotmore, S.F., Agbandje-McKenna, M., Canuti, M., Chiorini, J.A., Eis-Hubinger, A.M., Hughes, J., Mietzsch, M., Tijssen, P., ICTV virus taxonomy profile: Parvoviridae (2019) J. Gen. Virol., 100 (3), pp. 367-368; Chinchkar, S.R., Subramanian, B.M., Rao, N.H., Rangarajan, P.N., Thiagarajan, D., Srinivasan, V.A., Analysis of VP2 gene sequences of canine parvovirus isolates in India (2006) Arch. Virol., 151 (9), pp. 1881-1887; Miranda, C., Canine parvovirus: The characterization of field infections in Portugal (doctoral dissertation) (2016) Biomedical Sciences, p. 216. , University of Porto, Abel Salazar Biomedical Sciences Institute; Clark, N.J., Seddon, J.M., Kyaw-Tanner, M., Al-Alawneh, J., Harper, G., McDonagh, P., Meers, J., Emergence of canine parvovirus subtype 2b (CPV-2b) infections in Australian dogs (2018) Infect. Genet. Evol., 58, pp. 50-55; Bucci, T.J., Botros, A.M., El-Molla, M., Canine parvovirus infection: A brief review and report of fist cases in Egypt (1982) J. Egypt. Vet. Med. Assoc., 42 (1), pp. 21-25; Mohamed, A.M., (1988) Studies on Parvovirus in Dogs, , Master's Dissertation), in Department of Microbiology-Faculty of Veterinary Medicine. Cairo University, Egypt; Aly, N.I., Salama, Z.T.S., Preparation of an inactivated penta cell culture vaccine against canine distemper, canine parvo, canine hepatitis “canine adeno-1”, canine adeno-2 and rabies viruses for dogs (2005) Beni-Suef Vet. Med. J., 15 (2), pp. 208-214; El-Gallad, S.B., Rofaiil, S.K., Attyat, M.K., Investigation of the effect of different adjuvants in the inactivated canine parvo vaccine on the immune response of puppies (2007) Zag. Vet. J., 35 (2), pp. 172-178; Soliman, A.F., Comparative studies on propagation of some canine viruses on MDCK cell culture without serum (2011) Zag. Vet. J., 39 (4), pp. 130-134; Ali, N.I., Salama, Z.T.S., El-Emam, H.S., Oral vaccination of puppies with the core vaccines (canine distemper; canine parvo; canine hepatitis and rabies vaccines) (2011) Kafrelsheikh Vet. Med. J., 9 (2), pp. 73-90; Yanni, M.I., (2012) Isolation and Characterization of Canine Parvovirus-2 in Egypt, , Doctoral Dissertation), in Department of Virology-Faculty of Veterinary Medicine. Cairo University, Egypt; Amthal, A.F., (2014) Molecular Characterization of Canine Parvovirus-2 in Egypt, p. 139. , Doctoral Dissertation), in Department of Virology-Faculty of Veterinary Medicine. Cairo University, Egypt; AL-Hosary, A.A.T., Prevalence of parvovirus infection in household dogs with special reference to its effects on some blood parameters (2016) Alex. J. Vet. Sci., 51 (2), pp. 174-177; AL-Hosary, A.A.T., Detection and molecular characterization of parvovirus serotypes in Egypt (2018) J. Adv. Vet. Res., 8 (4), pp. 79-83; Soliman, R.M., Baker, N.M., Nasr, M.Y., Khodeir, M.H., Clinical, virological and molecular characterization of canine parvovirus in dogs (2018) Eur. J. Pharm. Med. Res., 5 (4), pp. 525-535; Xiong, N., Zhang, Y., Wang, Y., Yang, B.Y., Chen, S.Y., Isolation and identification of canine parvovirus serotype 2a and its VP2 protein expression in transgenic tobacco (2008) Virol. Sin., 3 (23), pp. 203-210; Sharma, S., Dhar, P., Thakur, A., Sharma, V., Sharma, M., First detection of canine parvovirus Type 2b from diarrheic dogs in Himachal Pradesh (2016) Vet. World, 9 (9), pp. 964-969; Altschul, S.F., Gish, W., Miller, W., Myers, E.W., Lipman, D.J., Basic local alignment search tool (1990) J. Mol. Biol., 215 (3), pp. 403-410; Saitou, N., Nei, M., The neighbor-joining method: A new method for reconstructing phylogenetic trees (1987) Mol. Biol. Evol., 4 (4), pp. 406-425; Nei, M., Kumar, S., (2000) Molecular Evolution and Phylogenetics, , Oxford University Press, New York; Kumar, S., Stecher, G., Li, M., Knyaz, C., Tamura, K., Mega X: Molecular evolutionary genetics analysis across computing platforms (2018) Mol. Biol. Evol., 35 (6), pp. 1547-1549","El-Dabae, W.H.; Department of Microbiology and Immunology, Veterinary Research Division, National Research CentreEgypt; email: dr_wahidhussein@yahoo.com",,Veterinary World,9728988,,,,English,Vet. World,Article,Final,Open Access,Scopus,2-s2.0-85080900379,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Dirmeier S., Dächert C., van Hemert M., Tas A., Ogando N.S., van Kuppeveld F., Bartenschlager R., Kaderali L., Binder M., Beerenwinkel N.",55891934700;57201898541;55291601300;55277916400;57209637757;7004255109;57203048756;57210104492;8860755300;57203029155;,Host factor prioritization for pan-viral genetic perturbation screens using random intercept models and network propagation,2020,PLoS Computational Biology,16,2, e1007587,,,,,10.1371/journal.pcbi.1007587,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080848520&doi=10.1371%2fjournal.pcbi.1007587&partnerID=40&md5=79620edba73750790e0209955f1e3931,"Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland; SIB Swiss Institute of Bioinformatics, Basel, Switzerland; Research Group “Dynamics of Early Viral Infection and the Innate Antiviral Response” (division F170), German Cancer Research Center, Heidelberg, Germany; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany; Department of Medical Microbiology, Leiden University Medical Center, Leiden, Netherlands; Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands; Department for Infectious Diseases, Molecular Virology, Heidelberg University, Heidelberg, Germany; Division Virus-Associated Carcinogenesis, German Cancer Research Center, Heidelberg, Germany; University Medicine Greifswald, Institute of Bioinformatics, Greifswald, Germany","Dirmeier, S., Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland, SIB Swiss Institute of Bioinformatics, Basel, Switzerland; Dächert, C., Research Group “Dynamics of Early Viral Infection and the Innate Antiviral Response” (division F170), German Cancer Research Center, Heidelberg, Germany, Faculty of Biosciences, Heidelberg University, Heidelberg, Germany; van Hemert, M., Department of Medical Microbiology, Leiden University Medical Center, Leiden, Netherlands; Tas, A., Department of Medical Microbiology, Leiden University Medical Center, Leiden, Netherlands; Ogando, N.S., Department of Medical Microbiology, Leiden University Medical Center, Leiden, Netherlands; van Kuppeveld, F., Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands; Bartenschlager, R., Department for Infectious Diseases, Molecular Virology, Heidelberg University, Heidelberg, Germany, Division Virus-Associated Carcinogenesis, German Cancer Research Center, Heidelberg, Germany; Kaderali, L., University Medicine Greifswald, Institute of Bioinformatics, Greifswald, Germany; Binder, M., Research Group “Dynamics of Early Viral Infection and the Innate Antiviral Response” (division F170), German Cancer Research Center, Heidelberg, Germany; Beerenwinkel, N., Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland, SIB Swiss Institute of Bioinformatics, Basel, Switzerland","Genetic perturbation screens using RNA interference (RNAi) have been conducted successfully to identify host factors that are essential for the life cycle of bacteria or viruses. So far, most published studies identified host factors primarily for single pathogens. Furthermore, often only a small subset of genes, e.g., genes encoding kinases, have been targeted. Identification of host factors on a pan-pathogen level, i.e., genes that are crucial for the replication of a diverse group of pathogens has received relatively little attention, despite the fact that such common host factors would be highly relevant, for instance, for devising broad-spectrum anti-pathogenic drugs. Here, we present a novel two-stage procedure for the identification of host factors involved in the replication of different viruses using a combination of random effects models and Markov random walks on a functional interaction network. We first infer candidate genes by jointly analyzing multiple perturbations screens while at the same time adjusting for high variance inherent in these screens. Subsequently the inferred estimates are spread across a network of functional interactions thereby allowing for the analysis of missing genes in the biological studies, smoothing the effect sizes of previously found host factors, and considering a priori pathway information defined over edges of the network. We applied the procedure to RNAi screening data of four different positive-sense single-stranded RNA viruses, Hepatitis C virus, Chikungunya virus, Dengue virus and Severe acute respiratory syndrome coronavirus, and detected novel host factors, including UBC, PLCG1, and DYRK1B, which are predicted to significantly impact the replication cycles of these viruses. We validated the detected host factors experimentally using pharmacological inhibition and an additional siRNA screen and found that some of the predicted host factors indeed influence the replication of these pathogens. © 2020 Dirmeier et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",,host factor; protein DYRK1B; protein PLCG1; protein UBC; unclassified drug; Article; Chikungunya virus; controlled study; effect size; genetic screening; Hepatitis C virus; life cycle; Markov chain; nonhuman; RNA interference; RNA virus; SARS coronavirus; virus replication,"Hannon, G., RNA interference (2002) Nature, 418 (6894), pp. 244-251. , https://doi.org/10.1038/418244a, PMID: 12110901; Boutros, M., Ahringer, J., The art and design of genetic screens: RNA interference (2008) Nature Reviews Genetics, 9 (7), p. 554. , https://doi.org/10.1038/nrg2364, PMID: 18521077; Ahlquist, P., Noueiry, A.O., Lee, W.M., Kushner, D.B., Dye, B.T., Host factors in positive-strand RNA virus genome replication (2003) Journal of Virology, 77 (15), pp. 8181-8186. , https://doi.org/10.1128/JVI.77.15.8181-8186.2003, PMID: 12857886; 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Biol.,Article,Final,Open Access,Scopus,2-s2.0-85080848520,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Kikkert M.,6602465125;,Innate Immune Evasion by Human Respiratory RNA Viruses,2020,Journal of Innate Immunity,12,1,,4,20,,3,10.1159/000503030,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85073779759&doi=10.1159%2f000503030&partnerID=40&md5=b3fc13341375f8d15d3af2340b356acd,"Department of Medical Microbiology, Leiden University Medical Center, Molecular Virology Laboratory, LUMC Center of Infectious Diseases LU-CID, Albinusdreef 2, Leiden, NL-2333 ZA, Netherlands","Kikkert, M., Department of Medical Microbiology, Leiden University Medical Center, Molecular Virology Laboratory, LUMC Center of Infectious Diseases LU-CID, Albinusdreef 2, Leiden, NL-2333 ZA, Netherlands","The impact of respiratory virus infections on the health of children and adults can be very significant. Yet, in contrast to most other childhood infections as well as other viral and bacterial diseases, prophylactic vaccines or effective antiviral treatments against viral respiratory infections are either still not available, or provide only limited protection. Given the widespread prevalence, a general lack of natural sterilizing immunity, and/or high morbidity and lethality rates of diseases caused by influenza, respiratory syncytial virus, coronaviruses, and rhinoviruses, this difficult situation is a genuine societal challenge. A thorough understanding of the virus-host interactions during these respiratory infections will most probably be pivotal to ultimately meet these challenges. This review attempts to provide a comparative overview of the knowledge about an important part of the interaction between respiratory viruses and their host: the arms race between host innate immunity and viral innate immune evasion. Many, if not all, viruses, including the respiratory viruses listed above, suppress innate immune responses to gain a window of opportunity for efficient virus replication and setting-up of the infection. The consequences for the host's immune response are that it is often incomplete, delayed or diminished, or displays overly strong induction (after the delay) that may cause tissue damage. The affected innate immune response also impacts subsequent adaptive responses, and therefore viral innate immune evasion often undermines fully protective immunity. In this review, innate immune responses relevant for respiratory viruses with an RNA genome will briefly be summarized, and viral innate immune evasion based on shielding viral RNA species away from cellular innate immune sensors will be discussed from different angles. Subsequently, viral enzymatic activities that suppress innate immune responses will be discussed, including activities causing host shut-off and manipulation of stress granule formation. Furthermore, viral protease-mediated immune evasion and viral manipulation of the ubiquitin system will be addressed. Finally, perspectives for use of the reviewed knowledge for the development of novel antiviral strategies will be sketched. © 2019 The Author(s) Published by S. 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Karger AG,1662811X,,,31610541,English,J. Innate Immun.,Review,Final,Open Access,Scopus,2-s2.0-85073779759,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Hu Z., Song C., Xu C., Jin G., Chen Y., Xu X., Ma H., Chen W., Lin Y., Zheng Y., Wang J., Hu Z., Yi Y., Shen H.",55652838900;57215696348;57215691671;57215373803;57215050641;57209278853;57215691105;57215784701;57215690820;57215686498;57215700013;57215385835;55649953900;57215374525;,"Clinical characteristics of 24 asymptomatic infections with COVID-19 screened among close contacts in Nanjing, China",2020,Science China Life Sciences,,,,,,,,10.1007/s11427-020-1661-4,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081702758&doi=10.1007%2fs11427-020-1661-4&partnerID=40&md5=89125c7c32340bffd7fa8a1be26c2d02,"Nanjing Infectious Disease Center, the Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, 210003, China; Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China; State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, 211166, China; Department of Radiology, the Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, 210003, China; Department of Clinical Research Center, the Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, 210003, China; Department of Maternal, Child and Adolescent Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China; Department of Critical Medicine, the Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, 210003, China","Hu, Z., Nanjing Infectious Disease Center, the Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, 210003, China, Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China; Song, C., Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China, State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, 211166, China; Xu, C., Department of Radiology, the Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, 210003, China; Jin, G., Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China, State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, 211166, China; Chen, Y., Nanjing Infectious Disease Center, the Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, 210003, China; Xu, X., Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China; Ma, H., Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China, State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, 211166, China; Chen, W., Department of Clinical Research Center, the Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, 210003, China; Lin, Y., Department of Maternal, Child and Adolescent Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China; Zheng, Y., Department of Critical Medicine, the Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, 210003, China; Wang, J., Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China; Hu, Z., Nanjing Infectious Disease Center, the Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, 210003, China; Yi, Y., Nanjing Infectious Disease Center, the Second Hospital of Nanjing, Nanjing University of Chinese Medicine, Nanjing, 210003, China; Shen, H., Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China, State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, 211166, China","Previous studies have showed clinical characteristics of patients with the 2019 novel coronavirus disease (COVID-19) and the evidence of person-to-person transmission. Limited data are available for asymptomatic infections. This study aims to present the clinical characteristics of 24 cases with asymptomatic infection screened from close contacts and to show the transmission potential of asymptomatic COVID-19 virus carriers. Epidemiological investigations were conducted among all close contacts of COVID-19 patients (or suspected patients) in Nanjing, Jiangsu Province, China, from Jan 28 to Feb 9, 2020, both in clinic and in community. Asymptomatic carriers were laboratory-confirmed positive for the COVID-19 virus by testing the nucleic acid of the pharyngeal swab samples. Their clinical records, laboratory assessments, and chest CT scans were reviewed. As a result, none of the 24 asymptomatic cases presented any obvious symptoms while nucleic acid screening. Five cases (20.8%) developed symptoms (fever, cough, fatigue, etc.) during hospitalization. Twelve (50.0%) cases showed typical CT images of ground-glass chest and 5 (20.8%) presented stripe shadowing in the lungs. The remaining 7 (29.2%) cases showed normal CT image and had no symptoms during hospitalization. These 7 cases were younger (median age: 14.0 years; P=0.012) than the rest. None of the 24 cases developed severe COVID-19 pneumonia or died. The median communicable period, defined as the interval from the first day of positive nucleic acid tests to the first day of continuous negative tests, was 9.5 days (up to 21 days among the 24 asymptomatic cases). Through epidemiological investigation, we observed a typical asymptomatic transmission to the cohabiting family members, which even caused severe COVID-19 pneumonia. Overall, the asymptomatic carriers identified from close contacts were prone to be mildly ill during hospitalization. However, the communicable period could be up to three weeks and the communicated patients could develop severe illness. These results highlighted the importance of close contact tracing and longitudinally surveillance via virus nucleic acid tests. Further isolation recommendation and continuous nucleic acid tests may also be recommended to the patients discharged. © 2020, Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature.",asymptomatic infections; China; close contact; COVID-19,,"Chan, J.F.W., Yuan, S., Kok, K.H., To, K.K.W., Chu, H., Yang, J., Xing, F., Poon, R.W.S., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, pp. 514-523; Chang, D., Lin, M., Wei, L., Xie, L., Zhu, G., Dela Cruz, C.S., Sharma, L., Epidemiologic and clinical characteristics of novel coronavirus infections involving 13 patients outside Wuhan, China (2020) JAMA; Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Wei, Y., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, pp. 507-513; (2020) New coronavirus pneumonia prevention and control program, , 5th; Ding, L., Cai, W., Jing, J.Q., Zhang, X.X., Cai, Y., Shi, J.W., Liang, Q.M., Qu, J.M., An interim review of lessons from the novel coronavirus (SARS-CoV-2) outbreak in China (2020) Sci Sin Vitae, 50. , https://doi.org/10.1360/SSV-2020-0044; Guan, W.J., Ni, Z.Y., Hu, Y., Liang, W.H., Ou, C.Q., He, J.X., Liu, L., Hui, D.S.C., Clinical characteristics of coronavirus disease 2019 in China (2020) N Engl J Med; Heymann, D.L., Shindo, N., COVID-19: what is next for public health? (2020) Lancet, pp. 542-545; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Gu, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506. , COI: 1:CAS:528:DC%2BB3cXhs1Kqu7c%3D; Lu, R., Zhao, X., Li, J., Niu, P., Yang, B., Wu, H., Wang, W., Zhu, N., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet, 395, pp. 565-574; Phan, L.T., Nguyen, T.V., Luong, Q.C., Nguyen, T.V., Nguyen, H.T., Le, H.Q., Nguyen, T.T., Pham, Q.D., Importation and human-to-human transmission of a novel coronavirus in Vietnam (2020) N Engl J Med, pp. 872-874; (2020) Diamond Princess (ship), , https://en.wikipedia.org/wiki/Diamond_Princess_(ship); Wu, J.T., Leung, K., Leung, G.M., Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study (2020) Lancet, 395, pp. 689-697; Yang, Y., Lu, Q., Liu, M., Wang, Y., Zhang, A., Jalali, N., Dean, N., Xu, B., Epidemiological and clinical features of the 2019 novel coronavirus outbreak in China (2020) medRxiv; Zhang, Z., Li, X., Zhang, W., Shi, Z.L., Zheng, Z., Wang, T., Clinical Features and Treatment of 2019-nCov Pneumonia Patients in Wuhan: Report of A Couple Cases (2020) Virol Sin; Zou, L., Ruan, F., Huang, M., Liang, L., Huang, H., Hong, Z., Yu, J., Xia, J., SARS-CoV-2 viral load in upper respiratory specimens of infected patients (2020) N Engl J Med","Hu, Z.; Nanjing Infectious Disease Center, the Second Hospital of Nanjing, Nanjing University of Chinese MedicineChina; email: zhibin_hu@njmu.edu.cn",,Science in China Press,16747305,,,,English,Sci. China Life Sci.,Article,Article in Press,Open Access,Scopus,2-s2.0-85081702758,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Roosa K., Lee Y., Luo R., Kirpich A., Rothenberg R., Hyman J.M., Yan P., Chowell G.",57204358376;57214939518;57054886000;57214936433;7005459918;7005695085;57214930718;9845935500;,"Real-time forecasts of the COVID-19 epidemic in China from February 5th to February 24th, 2020",2020,Infectious Disease Modelling,5,,,256,263,,,10.1016/j.idm.2020.02.002,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079524058&doi=10.1016%2fj.idm.2020.02.002&partnerID=40&md5=d091f8a6710f260ff73357ce18fcc97e,"Department of Population Health Sciences, School of Public Health, Georgia State University, Atlanta, GA, United States; Department of Mathematics, Center for Computational Science, Tulane University, New Orleans, LA, United States; Infectious Disease Prevention and Control Branch, Public Health Agency of Canada, Ottawa, Canada","Roosa, K., Department of Population Health Sciences, School of Public Health, Georgia State University, Atlanta, GA, United States; Lee, Y., Department of Population Health Sciences, School of Public Health, Georgia State University, Atlanta, GA, United States; Luo, R., Department of Population Health Sciences, School of Public Health, Georgia State University, Atlanta, GA, United States; Kirpich, A., Department of Population Health Sciences, School of Public Health, Georgia State University, Atlanta, GA, United States; Rothenberg, R., Department of Population Health Sciences, School of Public Health, Georgia State University, Atlanta, GA, United States; Hyman, J.M., Department of Mathematics, Center for Computational Science, Tulane University, New Orleans, LA, United States; Yan, P., Infectious Disease Prevention and Control Branch, Public Health Agency of Canada, Ottawa, Canada; Chowell, G., Department of Population Health Sciences, School of Public Health, Georgia State University, Atlanta, GA, United States","The initial cluster of severe pneumonia cases that triggered the COVID-19 epidemic was identified in Wuhan, China in December 2019. While early cases of the disease were linked to a wet market, human-to-human transmission has driven the rapid spread of the virus throughout China. The Chinese government has implemented containment strategies of city-wide lockdowns, screening at airports and train stations, and isolation of suspected patients; however, the cumulative case count keeps growing every day. The ongoing outbreak presents a challenge for modelers, as limited data are available on the early growth trajectory, and the epidemiological characteristics of the novel coronavirus are yet to be fully elucidated. We use phenomenological models that have been validated during previous outbreaks to generate and assess short-term forecasts of the cumulative number of confirmed reported cases in Hubei province, the epicenter of the epidemic, and for the overall trajectory in China, excluding the province of Hubei. We collect daily reported cumulative confirmed cases for the 2019-nCoV outbreak for each Chinese province from the National Health Commission of China. Here, we provide 5, 10, and 15 day forecasts for five consecutive days, February 5th through February 9th, with quantified uncertainty based on a generalized logistic growth model, the Richards growth model, and a sub-epidemic wave model. Our most recent forecasts reported here, based on data up until February 9, 2020, largely agree across the three models presented and suggest an average range of 7409–7496 additional confirmed cases in Hubei and 1128–1929 additional cases in other provinces within the next five days. Models also predict an average total cumulative case count between 37,415 and 38,028 in Hubei and 11,588–13,499 in other provinces by February 24, 2020. Mean estimates and uncertainty bounds for both Hubei and other provinces have remained relatively stable in the last three reporting dates (February 7th – 9th). We also observe that each of the models predicts that the epidemic has reached saturation in both Hubei and other provinces. Our findings suggest that the containment strategies implemented in China are successfully reducing transmission and that the epidemic growth has slowed in recent days. © 2020 The Authors",China; Coronavirus; COVID-19; Phenomenological models; Real-time forecasts,2019 novel coronavirus; Article; bootstrapping; calibration; China; coronavirus disease 2019; epidemic; forecasting; human; least square analysis; mathematical model; phenomenology; prediction,"Ai, S., Zhu, G., Tian, F., Li, H., Gao, Y., Wu, Y., Lin, H., Population movement, city closure and spatial transmission of the 2019-nCoV infection in China (2020); Reported cases of 2019-nCoV https://ncov.dxy.cn/ncovh5/view/pneumonia?from=groupmessage&isappinstalled=0, Retrieved from; Reported cases of 2019-nCoV https://ncov.dxy.cn/ncovh5/view/pneumonia?from=groupmessage&isappinstalled=0, Retrieved from; Bürger, R., Chowell, G., Lara-Díıaz, L., Comparative analysis of phenomenological growth models applied to epidemic outbreaks (2019) Math Biosci Eng, 16 (5), pp. 4250-4273; Chowell, G., Fitting dynamic models to epidemic outbreaks with quantified uncertainty: A primer for parameter uncertainty, identifiability, and forecasts (2017) Infectectious Disease Modelling, 2, pp. 379-398; Chowell, G., Hincapie-Palacio, D., Ospina, J., Pell, B., Tariq, A., Dahal, S., Viboud, C., Using phenomenological models to characterize transmissibility and forecast patterns and final burden of Zika epidemics (2016) Public library of science, , 2016-05-31; Chowell, G., Tariq, A., Hyman, J.M., A novel sub-epidemic modeling framework for short-term forecasting epidemic waves (2019) BMC Medicine, 17 (1). , 164-164; Du, Z., Wang, L., Cauchemez, S., Xu, X., Wang, X., Cowling, B., Risk of 2019 novel coronavirus importations throughout China prior to the Wuhan quarantine (2020); Funk, S., Camacho, A., Kucharski, A.J., Eggo, R.M., Edmunds, W.J., Real-time forecasting of infectious disease dynamics with a stochastic semi-mechanistic model (2016) Epidemics, 22, pp. 56-61; Hopkins University, J., 2019 novel coronavirus (nCoV) data repository (2020) Center for systems science and engineering, , https://github.com/CSSEGISandData/2019-nCoV; Lai, S., Bogoch, I., Ruktanonchai, N., Watts, A., Li, Y., Yu, J., Tatem, A., Assessing spread risk of Wuhan novel coronavirus within and beyond China, January-April 2020: A travel network-based modelling study (2020); Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Feng, Z., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) New England Journal of Medicine; Pell, B., Kuang, Y., Viboud, C., Chowell, G., Using phenomenological models for forecasting the 2015 Ebola challenge (2018) Epidemics, 22, pp. 62-70; Read, J.M., Bridgen, J.R.E., Cummings, D.A.T., Ho, A., Jewell, C.P., Novel coronavirus 2019-nCoV: Early estimation of epidemiological parameters and epidemic predictions (2020); Richards, F., A flexible growth function for empirical use (1959) Journal of Experimental Botany, 10 (2), pp. 290-301; Riou, J., Althaus, C.L., Pattern of early human-to-human transmission of Wuhan 2019-nCoV (2020); Roosa, K., Chowell, G., Assessing parameter identifiability in compartmental dynamic models using a computational approach: Application to infectious disease transmission models (2019) Theoretical Biology and Medical Modelling, 16 (1); Roosa, K., Chowell, G., Coronavirus incidence forecasts (2020), https://publichealth.gsu.edu/coronavirus/; Shanafelt, D.W., Jones, G., Lima, M., Perrings, C., Chowell, G., Forecasting the 2001 foot-and-mouth disease epidemic in the UK (2017) EcoHealth; Steinbuch, Y., China opens second new hospital for coronavirus patients. New York Post (2020), https://nypost.com/2020/02/06/china-opens-second-new-hospital-for-coronavirus-patients/, Retrieved from; Viboud, C., Simonsen, L., Chowell, G., A generalized-growth model to characterize the early ascending phase of infectious disease outbreaks (2016) Epidemics, 15, pp. 27-37; Wang, X.-S., Wu, J., Yang, Y., Richards model revisited: Validation by and application to infection dynamics (2012) Journal of Theoretical Biology, 313, pp. 12-19; World Health Organization, W., Consensus document on the epidemiology of severe acute respiratory syndrome (SARS) (2003), https://who.int/csr/sars/en/WHOconsensus.pdf; World Health Organization, Novel coronavirus (2019-nCoV) situation reports (2020), https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports; Wu, J.T., Leung, K., Leung, G.M., Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: A modelling study (2020) The Lancet; Zhang, R., Liu, H., Li, F., Zhang, B., Liu, Q., Li, X., Transmission and epidemiological characteristics of Novel Coronavirus (2019-nCoV)-Infected Pneumonia(NCIP):preliminary evidence obtained in comparison with 2003-SARS (2020)","Chowell, G.; Department of Population Health Sciences, School of Public Health, Georgia State UniversityUnited States; email: gchowell@gsu.edu",,KeAi Communications Co.,24680427,,,,English,Infect. Dis. Modelling,Article,Final,Open Access,Scopus,2-s2.0-85079524058,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Tian S., Hu N., Lou J., Chen K., Kang X., Xiang Z., Chen H., Wang D., Liu N., Liu D., Chen G., Zhang Y., Li D., Li J., Lian H., Niu S., Zhang L., Zhang J.",57215411900;57206016029;57215419994;57215416762;57215411687;57215433297;57215421306;57215415307;57215425220;57215424480;57215411555;57215442309;57215418581;57215437023;56388351200;57215429793;57215425912;19639621200;,Characteristics of COVID-19 infection in Beijing,2020,Journal of Infection,80,4,,401,406,,1,10.1016/j.jinf.2020.02.018,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080879436&doi=10.1016%2fj.jinf.2020.02.018&partnerID=40&md5=e40ddadd3a5057dc5226c071772ebbb9,"Beijing Emergency Medicine Research Institute, Beijing Emergency Medical Center, Beijing, China; Beijing Emergency Medical Center, Beijing, China; Beijing Chao Yang District Emergency Medical Center, Beijing, China; Beijing Haidian District Medical Rescue Center, Beijing, China; Beijing Luhe Hospital, Capital Medical University, Beijing, China; Beijing Dongcheng District Emergency Medical Center, Beijing, China; Beijing Shijingshan District Hospital, Beijing, China; Beijing Daxing District People's Hospital, Beijing, China","Tian, S., Beijing Emergency Medicine Research Institute, Beijing Emergency Medical Center, Beijing, China; Hu, N., Beijing Emergency Medical Center, Beijing, China; Lou, J., Beijing Emergency Medicine Research Institute, Beijing Emergency Medical Center, Beijing, China; Chen, K., Beijing Chao Yang District Emergency Medical Center, Beijing, China; Kang, X., Beijing Emergency Medicine Research Institute, Beijing Emergency Medical Center, Beijing, China; Xiang, Z., Beijing Emergency Medical Center, Beijing, China; Chen, H., Beijing Emergency Medical Center, Beijing, China; Wang, D., Beijing Haidian District Medical Rescue Center, Beijing, China; Liu, N., Beijing Luhe Hospital, Capital Medical University, Beijing, China; Liu, D., Beijing Dongcheng District Emergency Medical Center, Beijing, China; Chen, G., Beijing Shijingshan District Hospital, Beijing, China; Zhang, Y., Beijing Daxing District People's Hospital, Beijing, China; Li, D., Beijing Emergency Medical Center, Beijing, China; Li, J., Beijing Emergency Medical Center, Beijing, China; Lian, H., Beijing Emergency Medicine Research Institute, Beijing Emergency Medical Center, Beijing, China; Niu, S., Beijing Emergency Medicine Research Institute, Beijing Emergency Medical Center, Beijing, China; Zhang, L., Beijing Emergency Medicine Research Institute, Beijing Emergency Medical Center, Beijing, China; Zhang, J., Beijing Emergency Medicine Research Institute, Beijing Emergency Medical Center, Beijing, China","Background: Since the first case of a novel coronavirus (COVID-19) infection pneumonia was detected in Wuhan, China, a series of confirmed cases of the COVID-19 were found in Beijing. We analyzed the data of 262 confirmed cases to determine the clinical and epidemiological characteristics of COVID-19 in Beijing. Methods: We collected patients who were transferred by Beijing Emergency Medical Service to the designated hospitals. The information on demographic, epidemiological, clinical, laboratory test for the COVID-19 virus, diagnostic classification, cluster case and outcome were obtained. Furthermore we compared the characteristics between severe and common confirmed cases which including mild cases, no-pneumonia cases and asymptomatic cases, and we also compared the features between COVID-19 and 2003 SARS. Findings: By Feb 10, 2020, 262 patients were transferred from the hospitals across Beijing to the designated hospitals for special treatment of the COVID-19 infected by Beijing emergency medical service. Among of 262 patients, 46 (17.6%) were severe cases, 216 (82.4%) were common cases, which including 192 (73.3%) mild cases, 11(4.2%) non-pneumonia cases and 13 (5.0%) asymptomatic cases respectively. The median age of patients was 47.5 years old and 48.5% were male. 192 (73.3%) patients were residents of Beijing, 50 (26.0%) of which had been to Wuhan, 116 (60.4%) had close contact with confirmed cases, 21 (10.9%) had no contact history. The most common symptoms at the onset of illness were fever (82.1%), cough (45.8%), fatigue (26.3%), dyspnea (6.9%) and headache (6.5%). The median incubation period was 6.7 days, the interval time from between illness onset and seeing a doctor was 4.5 days. As of Feb 10, 17.2% patients have discharged and 81.7% patients remain in hospital in our study, the fatality of COVID-19 infection in Beijing was 0.9%. Interpretation: On the basis of this study, we provided the ratio of the COVID-19 infection on the severe cases to the mild, asymptomatic and non-pneumonia cases in Beijing. Population was generally susceptible, and with a relatively low fatality rate. The measures to prevent transmission was very successful at early stage, the next steps on the COVID-19 infection should be focused on early isolation of patients and quarantine for close contacts in families and communities in Beijing. Funding: Beijing Municipal Science and Technology Commission and Ministry of Science and Technology. © 2020 Elsevier Ltd",2019-nCoV; Beijing; Characteristics; COVID-19,,"(2020), https://www.who.int/news-room/detail/12-02-2020-world-experts-and-funders-set-priorities-for-covid-19-research, WHO. World experts and funders set priorities for COVID-19 research. 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Beijing: national health commission of the People's Republic of China (accessed Feb 10, 2020); Update on the novel coronavirus pneumonia outbreak (2020), http://wjw.beijing.gov.cn/xwzx_20031/wnxw/202002/t20200211_1628034.html, February 10, 2020 Beijing Health Commission Beijing (accessed Feb 5, 2020); Wang, C., Horby, P.W., Hayden, F.G., Gao, G.F., A novel coronavirus outbreak of global health concern (2020) Lancet, , (Epub ahead of print); Munster, V.J., Koopmans, M., van Doremalen, N., A novel coronavirus emerging in China-key questions for impact assessment (2020) N Engl J Med, , (Epub ahead of print); Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, , (Epub ahead of print); Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med, , (Epub ahead of print); http://www.nhc.gov.cn/xcs/zhengcwj/202001/c67cfe29ecf1470e8c7fc47d3b751e88.shtml, New coronavirus pneumonial prevention and control program (2nd ed.) (in Chinese). 2020 () (accessedFeb 10, 2020); http://www.nhc.gov.cn/xcs/zhengcwj/202001/f492c9153ea9437bb587ce2ffcbee1fa.shtml, New coronavirus pneumonial diagnosis and treatment program (3rd ed.) (in Chinese). 2020(accessed Feb10, 2020); http://www.nhc.gov.cn/xcs/zhengcwj/202002/3b09b894ac9b4204a79db5b8912d4440.shtml, New coronavirus pneumonial diagnosis and treatment program (5th ed.) (in Chinese). 2020 (accessed Feb10, 2020); Chan, J.F., Chan, K.H., Kao, R.Y., Broad-spectrum antivirals for the emerging middle east respiratory syndrome coronavirus (2013) J Infect, 67 (6), pp. 606-616; Drazen, J.M., SARS-looking back over the first 100 days (2003) N Engl J Med, 349 (4), pp. 319-320; Chen, N.S., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, , Jan 24 (Epub ahead of print); Chan, J.F., Yuan, S., Kok, K.H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, , Jan 24 (Epub ahead of print); Rothe, C., Schunk, M., Sothmann, P., Transmission of 2019-nCoV infection from an asymptomatic contact in Germany (2020) N Engl J Med, , Jan 30(Epub ahead of print; Wu, J.T., Leung, K., Leung, G.M., Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study (2020) Lancet, , Jan 31(Epub ahead of print; Yang, S., Wu, J., Ding, C., Epidemiological features of and changes in incidence of infectious diseases in China in the first decade after the SARS outbreak: an observational trend study (2017) Lancet Infect Dis, 17 (7), pp. 716-725","Zhang, J.; Beijing Emergency Medicine Research Institute, Beijing Emergency Medical CenterChina; email: zhang92560@163.com",,W.B. Saunders Ltd,1634453,,JINFD,32112886,English,J. Infect.,Article,Final,Open Access,Scopus,2-s2.0-85080879436,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Li J., Liu M., Gao J., Jiang Y., Wu L., Cheong Y.-K., Ren G., Yang Z.",57215193848;57215199088;57215185348;57210989127;57209564066;56954553500;57211653204;35254805300;,AVNP2 protects against cognitive impairments induced by C6 glioma by suppressing tumour associated inflammation in rats,2020,"Brain, Behavior, and Immunity",,,,,,,,10.1016/j.bbi.2020.02.009,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080041857&doi=10.1016%2fj.bbi.2020.02.009&partnerID=40&md5=04fd6a283f710b3f0fd41c45026166da,"Medical School, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for Ministry of Education, Nankai University, Tianjin, 300071, China; Institute of Laser and Optoelectronics, School of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin, 300072, China; Science and Technology Research Institute, University of Hertfordshire, Hatfield, Herts AL10 9AB, United Kingdom","Li, J., Medical School, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for Ministry of Education, Nankai University, Tianjin, 300071, China; Liu, M., Medical School, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for Ministry of Education, Nankai University, Tianjin, 300071, China; Gao, J., Medical School, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for Ministry of Education, Nankai University, Tianjin, 300071, China; Jiang, Y., Medical School, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for Ministry of Education, Nankai University, Tianjin, 300071, China; Wu, L., Institute of Laser and Optoelectronics, School of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin, 300072, China; Cheong, Y.-K., Science and Technology Research Institute, University of Hertfordshire, Hatfield, Herts AL10 9AB, United Kingdom; Ren, G., Science and Technology Research Institute, University of Hertfordshire, Hatfield, Herts AL10 9AB, United Kingdom; Yang, Z., Medical School, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials for Ministry of Education, Nankai University, Tianjin, 300071, China","Glioblastoma is a kind of malignant tumour and originates from the central nervous system. In the last century, some researchers and clinician have noticed that the psychosocial and neurocognitive functioning of patients with malignant gliomas can be impaired. Many clinical studies have demonstrated that part of patients, adults or children, diagnosed with glioblastoma will suffer from cognitive deficiency during their clinical course, especially in long-term survivors. Many nanoparticles (NPs) can inhibit the biological functions of tumours by modulating tumour-associated inflammation, which provokes angiogenesis and tumour growth. As one of the best antiviral nanoparticles (AVNPs), AVNP2 is the 2nd generation of AVNP2 that have been conjugated to graphite-graphene for improving physiochemical performance and reducing toxicity. AVNP2 inactivates viruses, such as the H1N1 and H5N1influenza viruses and even the SARS coronavirus, while it inhibits bacteria, such as MRSA and E. coli. As antimicrobials, nanoparticles are considered to be one of the vectors for the administration of therapeutic compounds. Yet, little is known about their potential functionalities and toxicities to the neurotoxic effects of cancer. Herein, we explored the functionality of AVNP2 on inhibiting C6 in glioma-bearing rats. The novel object-recognition test and open-field test showed that AVNP2 significantly improved the neuro-behaviour affected by C6 glioma. AVNP2 also alleviated the decline of long-term potentiation (LTP) and the decreased density of dendritic spines in the CA1 region induced by C6. Western blot assay and immunofluorescence staining showed that the expressions of synaptic-related proteins (PSD-95 and SYP) were increased, and these findings were in accordance with the results mentioned above. It revealed that the sizes of tumours in C6 glioma-bearing rats were smaller after treatment with AVNP2. The decreased expression of inflammatory factors (IL-1β, IL-6 and TNF-α) by Western blotting assay and ELISA, angiogenesis protein (VEGF) by Western blotting assay and other related proteins (BDNF, NF-ĸB, iNOS and COX-2) by Western blotting assay in peri-tumour tissue indicated that AVNP2 could control tumour-associated inflammation, thus efficiently ameliorating the local inflammatory condition and, to some extent, inhibiting angiogenesis in C6-bearing rats. In conclusion, our results suggested that AVNP2 could have an effect on the peri-tumor environment, obviously restraining the growth progress of gliomas, and eventually improving cognitive levels in C6-bearing rats. © 2020 The Authors",AVNP2; C6 glioma; Cognitive function; Inflammation,,"Zong, H., Verhaak, R.G., Canoll, P., The cellular origin for malignant glioma and prospects for clinical advancements (2012) Expert Rev. Mol. 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Immun.,Article,Article in Press,Open Access,Scopus,2-s2.0-85080041857,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Yang X., Yu Y., Xu J., Shu H., Xia J., Liu H., Wu Y., Zhang L., Yu Z., Fang M., Yu T., Wang Y., Pan S., Zou X., Yuan S., Shang Y.",56593788400;56920918500;56883258800;24492656200;57214460628;57215089396;57215080424;57215091782;23394385900;57215094594;57214909863;57215097996;57161851300;57207416215;57215079290;8889759900;,"Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study",2020,The Lancet Respiratory Medicine,,,,,,,25,10.1016/S2213-2600(20)30079-5,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079841872&doi=10.1016%2fS2213-2600%2820%2930079-5&partnerID=40&md5=45e03f8fcc7bb2ce2b3528a63c11a48c,"Department of Critical Care Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Institute of Anesthesiology and Critical Care Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Union Hospital, Department of Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Jin Yin-tan Hospital, Wuhan, China; Department of Critical Care Medicine, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Hubei, China; Department of Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, China","Yang, X., Department of Critical Care Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, Institute of Anesthesiology and Critical Care Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, Jin Yin-tan Hospital, Wuhan, China; Yu, Y., Department of Critical Care Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, Institute of Anesthesiology and Critical Care Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Xu, J., Department of Critical Care Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, Institute of Anesthesiology and Critical Care Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Shu, H., Department of Critical Care Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, Institute of Anesthesiology and Critical Care Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Xia, J., Jin Yin-tan Hospital, Wuhan, China; Liu, H., Department of Critical Care Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, Institute of Anesthesiology and Critical Care Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, Jin Yin-tan Hospital, Wuhan, China; Wu, Y., Department of Critical Care Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, Institute of Anesthesiology and Critical Care Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Zhang, L., Department of Critical Care Medicine, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Hubei, China; Yu, Z., Department of Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, China; Fang, M., Union Hospital, Department of Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Yu, T., Jin Yin-tan Hospital, Wuhan, China; Wang, Y., Department of Critical Care Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, Institute of Anesthesiology and Critical Care Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Pan, S., Department of Critical Care Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, Institute of Anesthesiology and Critical Care Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Zou, X., Department of Critical Care Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, Institute of Anesthesiology and Critical Care Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Yuan, S., Department of Critical Care Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, Institute of Anesthesiology and Critical Care Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Shang, Y., Department of Critical Care Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, Institute of Anesthesiology and Critical Care Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, Jin Yin-tan Hospital, Wuhan, China","Background: An ongoing outbreak of pneumonia associated with the severe acute respiratory coronavirus 2 (SARS-CoV-2) started in December, 2019, in Wuhan, China. Information about critically ill patients with SARS-CoV-2 infection is scarce. We aimed to describe the clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia. Methods: In this single-centered, retrospective, observational study, we enrolled 52 critically ill adult patients with SARS-CoV-2 pneumonia who were admitted to the intensive care unit (ICU) of Wuhan Jin Yin-tan hospital (Wuhan, China) between late December, 2019, and Jan 26, 2020. Demographic data, symptoms, laboratory values, comorbidities, treatments, and clinical outcomes were all collected. Data were compared between survivors and non-survivors. The primary outcome was 28-day mortality, as of Feb 9, 2020. Secondary outcomes included incidence of SARS-CoV-2-related acute respiratory distress syndrome (ARDS) and the proportion of patients requiring mechanical ventilation. Findings: Of 710 patients with SARS-CoV-2 pneumonia, 52 critically ill adult patients were included. The mean age of the 52 patients was 59·7 (SD 13·3) years, 35 (67%) were men, 21 (40%) had chronic illness, 51 (98%) had fever. 32 (61·5%) patients had died at 28 days, and the median duration from admission to the intensive care unit (ICU) to death was 7 (IQR 3–11) days for non-survivors. Compared with survivors, non-survivors were older (64·6 years [11·2] vs 51·9 years [12·9]), more likely to develop ARDS (26 [81%] patients vs 9 [45%] patients), and more likely to receive mechanical ventilation (30 [94%] patients vs 7 [35%] patients), either invasively or non-invasively. Most patients had organ function damage, including 35 (67%) with ARDS, 15 (29%) with acute kidney injury, 12 (23%) with cardiac injury, 15 (29%) with liver dysfunction, and one (2%) with pneumothorax. 37 (71%) patients required mechanical ventilation. Hospital-acquired infection occurred in seven (13·5%) patients. Interpretation: The mortality of critically ill patients with SARS-CoV-2 pneumonia is considerable. The survival time of the non-survivors is likely to be within 1–2 weeks after ICU admission. Older patients (>65 years) with comorbidities and ARDS are at increased risk of death. The severity of SARS-CoV-2 pneumonia poses great strain on critical care resources in hospitals, especially if they are not adequately staffed or resourced. Funding: None. © 2020 Elsevier Ltd",,,"Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395, pp. 507-513; Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, , published online Jan 24; Holshue, M.L., DeBolt, C., Lindquist, S., First case of 2019 novel coronavirus in the United States (2020) N Engl J Med, , published online Jan 31; Wang, D., Hu, B., Hu, C., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) JAMA, , published online Feb 7; Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected (2020), https://www.who.int/publications-detail/clinical-management-of-severe-acute-respiratory-infection-when-novel-coronavirus-(ncov)-infection-is-suspected, (Accessed 8 February 2020); Dominguez-Cherit, G., Lapinsky, S.E., Macias, A.E., Critically ill patients with 2009 influenza A(H1N1) in Mexico (2009) JAMA, 302, pp. 1880-1887; Fowler, R.A., Lapinsky, S.E., Hallett, D., Critically ill patients with severe acute respiratory syndrome (2003) JAMA, 290, pp. 367-373; Kumar, A., Zarychanski, R., Pinto, R., Critically ill patients with 2009 influenza A(H1N1) infection in Canada (2009) JAMA, 302, pp. 1872-1879; https://isaric.tghn.org/, (Accessed 25 January 2020); KDIGO clinical practice guideline for acute kidney injury (2012), https://kdigo.org/wp-content/uploads/2016/10/KDIGO-2012-AKI-Guideline-English.pdf, (Accessed 8 February 2020); Parry, J., Wuhan: Britons to be evacuated as scientists estimate 44 000 cases of 2019-nCOV in the city (2020) BMJ, 368, p. m351; Lew, T.W., Kwek, T.K., Tai, D., Acute respiratory distress syndrome in critically ill patients with severe acute respiratory syndrome (2003) JAMA, 290, pp. 374-380; Gomersall, C.D., Joynt, G.M., Lam, P., Short-term outcome of critically ill patients with severe acute respiratory syndrome (2004) Intensive Care Med, 30, pp. 381-387; Arabi, Y.M., Arifi, A.A., Balkhy, H.H., Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection (2014) Ann Intern Med, 160, pp. 389-397; de Wit, E., van Doremalen, N., Falzarano, D., Munster, V.J., SARS and MERS: recent insights into emerging coronaviruses (2016) Nat Rev Microbiol, 14, pp. 523-534; Bellani, G., Laffey, J.G., Pham, T., Epidemiology, patterns of care, and mortality for patients with acute respiratory distress syndrome in intensive care units in 50 countries (2016) JAMA, 315, pp. 788-800; China built a hospital in 10 days to battle coronavirus https://www.usatoday.com/story/news/world/2020/02/03/coronavirus-photos-show-wuhan-huoshenshan-hospital-built-10-days/4643377002/, (Accessed 8 February 2020); Rothe, C., Schunk, M., Sothmann, P., Transmission of 2019-nCoV infection from an asymptomatic contact in Germany (2020) N Engl J Med, , published online Jan 30; Asymptomatic cases complicate efforts http://en.nhc.gov.cn/2020-02/01/c_76086.htm, (Accessed 8 February 2020); Gu, J., Gong, E., Zhang, B., Multiple organ infection and the pathogenesis of SARS (2005) J Exp Med, 202, pp. 415-424; Chu, H., Zhou, J., Wong, B.H., Middle East respiratory syndrome coronavirus efficiently infects human primary T lymphocytes and activates the extrinsic and intrinsic apoptosis pathways (2016) J Infect Dis, 213, pp. 904-914; Liu, W.J., Zhao, M., Liu, K., T-cell immunity of SARS-CoV: implications for vaccine development against MERS-CoV (2017) Antiviral Res, 137, pp. 82-92; Liu, L., Yang, Y., Gao, Z., Practice of diagnosis and management of acute respiratory distress syndrome in mainland China: a cross-sectional study (2018) J Thorac Dis, 10, pp. 5394-5404; Russell, C.D., Millar, J.E., Baillie, J.K., Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury (2020) Lancet, 395, pp. 473-475","Shang, Y.; Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyChina; email: you_shang@yahoo.com",,Lancet Publishing Group,22132600,,,,English,Lancet Respir. Med.,Article,Article in Press,Open Access,Scopus,2-s2.0-85079841872,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhao S., Chen H.",57204759587;57189381229;,Modeling the epidemic dynamics and control of COVID-19 outbreak in China,2020,Quantitative Biology,,,,,,,,10.1007/s40484-020-0199-0,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081720053&doi=10.1007%2fs40484-020-0199-0&partnerID=40&md5=73242afc7f3de3f5f2ce9bbad988d566,"CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China; China National Center for Bioinformation, Beijing, 100101, China; School of Future Technology, University of Chinese Academy of Sciences, Beijing, 100049, China; CAS Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, 650223, China","Zhao, S., CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China, China National Center for Bioinformation, Beijing, 100101, China, School of Future Technology, University of Chinese Academy of Sciences, Beijing, 100049, China; Chen, H., CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China, China National Center for Bioinformation, Beijing, 100101, China, School of Future Technology, University of Chinese Academy of Sciences, Beijing, 100049, China, CAS Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, 650223, China","Background: The coronavirus disease 2019 (COVID-19) is rapidly spreading in China and more than 30 countries over last two months. COVID-19 has multiple characteristics distinct from other infectious diseases, including high infectivity during incubation, time delay between real dynamics and daily observed number of confirmed cases, and the intervention effects of implemented quarantine and control measures. Methods: We develop a Susceptible, Un-quanrantined infected, Quarantined infected, Confirmed infected (SUQC) model to characterize the dynamics of COVID-19 and explicitly parameterize the intervention effects of control measures, which is more suitable for analysis than other existing epidemic models. Results: The SUQC model is applied to the daily released data of the confirmed infections to analyze the outbreak of COVID-19 in Wuhan, Hubei (excluding Wuhan), China (excluding Hubei) and four first-tier cities of China. We found that, before January 30, 2020, all these regions except Beijing had a reproductive number R > 1, and after January 30, all regions had a reproductive number R < 1, indicating that the quarantine and control measures are effective in preventing the spread of COVID-19. The confirmation rate of Wuhan estimated by our model is 0.0643, substantially lower than that of Hubei excluding Wuhan (0.1914), and that of China excluding Hubei (0.2189), but it jumps to 0.3229 after February 12 when clinical evidence was adopted in new diagnosis guidelines. The number of unquarantined infected cases in Wuhan on February 12, 2020 is estimated to be 3,509 and declines to 334 on February 21, 2020. After fitting the model with data as of February 21, 2020, we predict that the end time of COVID-19 in Wuhan and Hubei is around late March, around mid March for China excluding Hubei, and before early March 2020 for the four tier-one cities. A total of 80,511 individuals are estimated to be infected in China, among which 49,510 are from Wuhan, 17,679 from Hubei (excluding Wuhan), and the rest 13,322 from other regions of China (excluding Hubei). Note that the estimates are from a deterministic ODE model and should be interpreted with some uncertainty. Conclusions: We suggest that rigorous quarantine and control measures should be kept before early March in Beijing, Shanghai, Guangzhou and Shenzhen, and before late March in Hubei. The model can also be useful to predict the trend of epidemic and provide quantitative guide for other countries at high risk of outbreak, such as South Korea, Japan, Italy and Iran. [Figure not available: see fulltext.]. © 2020, Higher Education Press and Springer-Verlag GmbH Germany, part of Springer Nature.",coronavirus disease 2019; epidemic model; SARS-CoV-2,,"(2019) Wuhan Municipal Health Commission briefing on the pneumonia epidemic situation, , http://wjw.wuhan.gov.cn/front/web/showDetail/2019123108989; Wang, C., Horby, P.W., Hayden, F.G., Gao, G.F., A novel coronavirus outbreak of global health concern (2020) Lancet, 395, pp. 470-473; Chan, J.F.-W., Yuan, S., Kok, K.-H., To, K.K., Chu, H., Yang, J., Xing, F., Poon, R.W., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, 395, pp. 514-523. , COI: 1:CAS:528:DC%2BB3cXhs1Ojsro%3D; (2020) Infectious Disease Specialists. Prevention and control of novel coronavirus pneumonia, , http://www.nhc.gov.cn/jkj/s3577/202002/a5d6f7b8c48c451c87dba14889b30147.shtml; Du, Z., Wang, L., Chauchemez, S., Xu, X., Wang, X., Cowling, B.J., Meyers, L.A., Risk for transportation of 2019 novel coronavirus disease from Wuhan to other cities in China (2020) Emerg. Infect. Dis.; Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Ren, R., Wong, J., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N. Engl. J. Med.; Stehlé, J., Voirin, N., Barrat, A., Cattuto, C., Colizza, V., Isella, L., Régis, C., Van den Broeck, W., Simulation of an SEIR infectious disease model on the dynamic contact network of conference attendees (2011) BMC Med., 9, p. 87; Fisman, D., Khoo, E., Tuite, A., Early epidemic dynamics of the west african 2014 ebola outbreak: estimates derived with a simple two-parameter model (2014) PLoS Curr., 6, p. 6; Imai, N., Cori, A., Dorigatti, I., Imai, N., Cori, A., Dorigatti, I., Baguelin, M., Ferguson, N., (2020) Report 3: Transmissibility of 2019-n-CoV, , https://www.imperial.ac.uk/media/imperial-college/medicine/sph/ide/gida-fellowships/Imperial-2019-nCoV-transmissibility.pdf; Liu, T., Hu, J., Xiao, J., He, G., Kang, M., Rong, Z., Lin, L., Deng, A., (2020) Transmission dynamics of 2019 novel coronavirus (2019-nCoV); Majumder, M., Mandl, K.D., (2020) Early Transmissibility Assessment of a Novel Coronavirus in Wuhan, China, , https://papers.ssrn.com/abstract=3524675","Chen, H.; CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of SciencesChina; email: chenh@big.ac.cn",,Higher Education Press,20954689,,,,English,Quantitative Biol.,Article,Article in Press,Open Access,Scopus,2-s2.0-85081720053,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "More G.D., Dunowska M., Acke E., Cave N.J.",57211452480;6602358317;6508253866;57192935658;,A serological survey of canine respiratory coronavirus in New Zealand,2020,New Zealand Veterinary Journal,68,1,,54,59,,,10.1080/00480169.2019.1667282,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85074021232&doi=10.1080%2f00480169.2019.1667282&partnerID=40&md5=6913578cf0cfeeb79125a8c29707a769,"School of Veterinary Sciences, Massey University, Palmerston North, New Zealand; Vet Med Labor GmbH, IDEXX Laboratories, Ludwigsburg, Germany","More, G.D., School of Veterinary Sciences, Massey University, Palmerston North, New Zealand; Dunowska, M., School of Veterinary Sciences, Massey University, Palmerston North, New Zealand; Acke, E., School of Veterinary Sciences, Massey University, Palmerston North, New Zealand, Vet Med Labor GmbH, IDEXX Laboratories, Ludwigsburg, Germany; Cave, N.J., School of Veterinary Sciences, Massey University, Palmerston North, New Zealand","Aims: To determine the seroprevalence of canine respiratory coronavirus (CRCoV) in New Zealand dogs, and to explore associations with age, sex, breed, month, and geographical region of sampling and reported presence of clinical signs suggestive of respiratory disease. Methods: A total of 1,015 canine serum samples were randomly selected from submissions to a diagnostic laboratory between March and December 2014, and were analysed for CRCoV antibodies using a competitive ELISA. Logistic regression analysis was used to determine associations between seroprevalence of CRCoV and breed category, age, sex, sampling month, region, and reported health status of dogs. Results: Overall, 538/1,015 (53.0%) samples were seropositive for CRCoV, with 492/921 (53.4%) positive dogs in the North Island and 46/94 (49%) in the South Island. Age of dog, sampling month, region, and presence of abnormal respiratory signs were included in the initial logistic regression model. Seroprevalence was higher in dogs aged ≥3 compared with ≤2 years (p < 0.01). The lowest seroprevalence was observed in July (30/105; 28.5%) and August (32/100; 32%), and the highest in June (74/100; 74%). Seroprevalence in dogs from Auckland was higher than in dogs from the Hawkes Bay, Manawatu, Marlborough, and Waikato regions (p < 0.05). Abnormal respiratory signs (coughing, nasal discharge, or sneezing) were reported for 28/1,015 (2.8%) dogs sampled. Seroprevalence for CRCoV tended to be higher among dogs with respiratory signs (67.9 (95% CI = 47.6–83.4)%) than dogs with no reported respiratory signs (52.6 (95% CI = 49.5–55.7)%). Conclusions: Serological evidence of infection with CRCoV was present in more than half of the dogs tested from throughout New Zealand. Differences in CRCoV seroprevalence between regions and lack of seasonal pattern indicate that factors other than external temperatures may be important in the epidemiology of CRCoV in New Zealand. Clinical relevance: Our data suggest that CRCoV should be included in investigations of cases of infectious canine tracheobronchitis, particularly if these occur among dogs vaccinated with current vaccines, which do not include CRCoV antigens. © 2019, © 2019 New Zealand Veterinary Association.",Canine respiratory coronavirus; ELISA; New Zealand; seroprevalence; survey,"virus antibody; animal; blood; Canine coronavirus; Coronavirus infection; dog; dog disease; enzyme linked immunosorbent assay; immunology; isolation and purification; New Zealand; seroepidemiology; statistical model; veterinary medicine; virology; Animals; Antibodies, Viral; Coronavirus Infections; Coronavirus, Canine; Dog Diseases; Dogs; Enzyme-Linked Immunosorbent Assay; Logistic Models; New Zealand; Seroepidemiologic Studies","An, D.-J., Jeoung, H.-Y., Jeong, W., Chae, S., Song, D.-S., Oh, J.-S., Park, B.-K., A serological survey of canine respiratory coronavirus and canine influenza virus in Korean dogs (2010) The Journal of Veterinary Medical Science, 72, pp. 1217-1219; Decaro, N., Desario, C., Elia, G., Mari, V., Lucente, M.S., Cordioli, P., Colaianni, M.L., Buonavoglia, C., Serological and molecular evidence that canine respiratory coronavirus is circulating in Italy (2007) Veterinary Microbiology, 121, pp. 225-230; Ellis, J.A., McLean, N., Hupaelo, R., Haines, D.M., Detection of coronavirus in cases of tracheobronchitis in dogs: a retrospective study from 1971 to 2003 (2005) The Canadian Veterinary Journal, 46, p. 447; Erles, K., Toomey, C., Brooks, H.W., Brownlie, J., Detection of a group 2 coronavirus in dogs with canine infectious respiratory disease (2003) Virology, 310, pp. 216-223; Erles, K., Brownlie, J., Investigation into the causes of canine infectious respiratory disease: antibody responses to canine respiratory coronavirus and canine herpesvirus in two kennelled dog populations (2005) Archives of Virology, 150, pp. 1493-1504; Erles, K., Brownlie, J., Canine respiratory coronavirus: an emerging pathogen in the canine infectious respiratory disease complex (2008) Veterinary Clinics of North America: Small Animal Practice, 38, pp. 815-825; Kaneshima, T., Hohdatsu, T., Satoh, K., Takano, T., Motokawa, K., Koyama, H., The prevalence of a group 2 coronavirus in dogs in Japan (2006) The Journal of Veterinary Medical Science, 68, pp. 21-25; Knesl, O., Allan, F., Shields, S., The seroprevalence of canine respiratory coronavirus and canine influenza virus in dogs in New Zealand (2009) New Zealand Veterinary Journal, 57, pp. 295-298; Mitchell, J.A., Cardwell, J.M., Leach, H., Walker, C.A., Le Poder, S., Decaro, N., Rusvai, M., Fernandez, M., European surveillance of emerging pathogens associated with canine infectious respiratory disease (2017) Veterinary Microbiology, 212, pp. 31-38; Priestnall, S.L., Brownlie, J., Dubovi, E.J., Erles, K., Serological prevalence of canine respiratory coronavirus (2006) Veterinary Microbiology, 115, pp. 43-53; Priestnall, S.L., Pratelli, A., Brownlie, J., Erles, K., Serological prevalence of canine respiratory coronavirus in southern Italy and epidemiological relationship with canine enteric coronavirus (2007) Journal of Veterinary Diagnostic Investigation, 19, pp. 176-180; Soma, T., Ishii, H., Miyata, K., Hara, M., Prevalence of antibodies to canine respiratory coronavirus in some dog populations in Japan (2008) Veterinary Record, 163, pp. 368-369; Sowman, H.R., Cave, N.J., Dunowska, M., A survey of canine respiratory pathogens in New Zealand dogs (2018) New Zealand Veterinary Journal, 66, pp. 236-242","Dunowska, M.; School of Veterinary Sciences, Massey UniversityNew Zealand; email: m.dunowska@massey.ac.nz",,Taylor and Francis Ltd.,480169,,NEZTA,31513753,English,New Zealand Vet. J.,Article,Final,Open Access,Scopus,2-s2.0-85074021232,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Fu J., Chen R., Hu J., Qu H., Zhao Y., Cao S., Wen X., Wen Y., Wu R., Zhao Q., Ma X., Huang X.",57211966467;57211968806;57211967395;57211966200;57211969827;26031318600;26031746800;55693768900;55951453600;55743369600;55838578000;54412415500;,Identification of a novel linear B-cell epitope on the nucleocapsid protein of porcine deltacoronavirus,2020,International Journal of Molecular Sciences,21,2,648,,,,,10.3390/ijms21020648,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078198970&doi=10.3390%2fijms21020648&partnerID=40&md5=996242df5a6f831a9380a55082346b21,"Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China; Sichuan Science-observation Experimental station of Veterinary Drugs and Veterinary Diagnostic Technology, Ministry of Agriculture, Chengdu, 611130, China; National Teaching and Experiment Center of Animal, Sichuan Agricultural University, Chengdu, 611130, China","Fu, J., Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China; Chen, R., Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China; Hu, J., Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China; Qu, H., Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China; Zhao, Y., Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China; Cao, S., Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China, Sichuan Science-observation Experimental station of Veterinary Drugs and Veterinary Diagnostic Technology, Ministry of Agriculture, Chengdu, 611130, China, National Teaching and Experiment Center of Animal, Sichuan Agricultural University, Chengdu, 611130, China; Wen, X., Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China; Wen, Y., Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China; Wu, R., Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China; Zhao, Q., Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China; Ma, X., Sichuan Science-observation Experimental station of Veterinary Drugs and Veterinary Diagnostic Technology, Ministry of Agriculture, Chengdu, 611130, China; Huang, X., Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China, Sichuan Science-observation Experimental station of Veterinary Drugs and Veterinary Diagnostic Technology, Ministry of Agriculture, Chengdu, 611130, China, National Teaching and Experiment Center of Animal, Sichuan Agricultural University, Chengdu, 611130, China","Porcine deltacoronavirus (PDCoV), first identified in 2012, is a swine enteropathogen now found in many countries. The nucleocapsid (N) protein, a core component of PDCoV, is essential for virus replication and is a significant candidate in the development of diagnostics for PDCoV. In this study, monoclonal antibodies (mAbs) were generated and tested for reactivity with three truncations of the full protein (N1, N2, N3) that contained partial overlaps; of the five monoclonals chosen tested, each reacted with only the N3 truncation. The antibody designated 4E88 had highest binding affinity with the N protein and was chosen for in-depth examination. The 4E88 epitope was located to amino acids 308-AKPKQQKKPKK-318 by testing the 4E88 monoclonal for reactivity with a series of N3 truncations, then the minimal epitope, 309-KPKQQKKPK-317 (designated EP-4E88), was pinpointed by testing the 4E88 monoclonal for reactivity with a series of synthetic peptides of this region. Homology analysis showed that the EP-4E88 sequence is highly conserved among PDCoV strains, and also shares high similarity with sparrow coronavirus (HKU17), Asian leopard cat coronavirus (ALCCoV), quail coronavirus (UAE-HKU30), and sparrow deltacoronavirus (SpDCoV). Of note, the PDCoV EP-4E88 sequence shared very low similarity (<22.2%) with other porcine coronaviruses (PEDV, TGEV, PRCV, SADS-CoV, PHEV), demonstrating that it is an epitope that can be used for distinguishing PDCoV and other porcine coronavirus. 3D structural analysis revealed that amino acids of EP-4E88 were in close proximity and may be exposed on the surface of the N protein. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.",Monoclonal antibodies; Nucleocapsid; Porcine deltacoronavirus,epitope; monoclonal antibody; nucleocapsid protein; nucleocapsid protein antibody; recombinant protein; unclassified drug; amino acid sequence; animal cell; animal experiment; antibody production; antibody titer; Article; B lymphocyte; binding affinity; controlled study; Coronavirinae; cross reaction; DNA sequencing; dot hybridization; enzyme linked immunosorbent assay; epitope mapping; female; hybridoma; immunofluorescence test; mouse; nonhuman; polymerase chain reaction; Porcine Deltacoronavirus; prediction; protein analysis; protein expression; protein purification; protein structure; sequence alignment; sequence analysis; sequence homology; Sp2/0-Ag14 cell line; Vero cell line; Western blotting,"Woo, P.C.Y., Lau, S.K.P., Lam, C.S.F., Lau, C.C.Y., Tsang, A.K.L., Lau, J.H.N., Bai, R., Wang, M., Discovery of seven novel Mammalian and avian coronaviruses in the genus deltacoronavirus supports bat coronaviruses as the gene source of alphacoronavirus and betacoronavirus and avian coronaviruses as the gene source of gammacoronavirus and deltacoronavirus (2012) J. 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Dis., 20, pp. 1594-1595; Lee, S., Lee, C., Complete Genome Characterization of Korean Porcine Deltacoronavirus Strain KOR/KNU14-04/2014 (2014) Genome Announc., 2; Song, D., Zhou, X., Peng, Q., Chen, Y., Zhang, F., Huang, T., Zhang, T., Wu, Q., Newly Emerged Porcine Deltacoronavirus Associated With Diarrhoea in Swine in China: Identification, Prevalence and Full-Length Genome Sequence Analysis (2015) Transbound. Emerg. Dis., 62, pp. 575-580; Wang, Y.-W., Yue, H., Fang, W., Huang, Y.-W., Complete Genome Sequence of Porcine Deltacoronavirus Strain CH/Sichuan/S27/2012 from Mainland China (2015) Genome Announc, 3, p. 945; Janetanakit, T., Lumyai, M., Bunpapong, N., Boonyapisitsopa, S., Chaiyawong, S., Nonthabenjawan, N., Kesdaengsakonwut, S., Amonsin, A., Porcine Deltacoronavirus, Thailand, 2015 (2016) Emerg. Infect. Dis., 22, pp. 757-759; Wang, L., Hayes, J., Sarver, C., Byrum, B., Zhang, Y., Porcine deltacoronavirus: Histological lesions and genetic characterization (2016) Arch. 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Protoc., 5, pp. 725-738; Zhang, Y., I-TASSER server for protein 3D structure prediction (2008) BMC Bioinform, 9 (40)","Huang, X.; Research Center of Swine Disease, College of Veterinary Medicine, Sichuan Agricultural UniversityChina; email: huangxiaobo@sicau.edu.cn",,MDPI AG,16616596,,,31963776,English,Int. J. Mol. Sci.,Article,Final,Open Access,Scopus,2-s2.0-85078198970,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Bai D., Fang L., Xia S., Ke W., Wang J., Wu X., Fang P., Xiao S.",57204166607;7402470374;57211411714;57193114863;57214696967;57195355049;57189253798;7402022567;,Porcine deltacoronavirus (PDCoV) modulates calcium influx to favor viral replication,2020,Virology,539,,,38,48,,,10.1016/j.virol.2019.10.011,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85073830902&doi=10.1016%2fj.virol.2019.10.011&partnerID=40&md5=b6a492427ddaff37db73bcf1ac7e5f1e,"State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 430070, China","Bai, D., State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 430070, China; Fang, L., State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 430070, China; Xia, S., State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 430070, China; Ke, W., State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 430070, China; Wang, J., State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 430070, China; Wu, X., State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 430070, China; Fang, P., State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 430070, China; Xiao, S., State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 430070, China","Ionic calcium (Ca2+) is a versatile intracellular second messenger that plays important roles in cellular physiological and pathological processes. Porcine deltacoronavirus (PDCoV) is an emerging enteropathogenic coronavirus that causes serious vomiting and diarrhea in suckling piglets. In this study, the role of Ca2+ to PDCoV infection was investigated. PDCoV infection was found to upregulate intracellular Ca2+ concentrations of IPI-2I cells. Chelating extracellular Ca2+ by EGTA inhibited PDCoV replication, and this inhibitory effect was overcome by replenishment with CaCl2. Treatment with Ca2+ channel blockers, particularly the L-type Ca2+ channel blocker diltiazem hydrochloride, inhibited PDCoV infection significantly. Mechanistically, diltiazem hydrochloride reduces PDCoV infection by inhibiting the replication step of the viral replication cycle. Additionally, knockdown of CACNA1S, the L-type Ca2+ voltage-gated channel subunit, inhibited PDCoV replication. 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Engl., 56, pp. 12908-12912; Zhu, X., Liu, S., Wang, X., Luo, Z., Shi, Y., Wang, D., Peng, G., Xiao, S., Contribution of porcine aminopeptidase N to porcine deltacoronavirus infection (2018) Emerg. Microb. Infect., 7, p. 65","Fang, L.; Laboratory of Animal Virology, College of Veterinary Medicine, Huazhong Agricultural University, 1 Shi-zi-shan Street, China; email: fanglr@mail.hzau.edu.cn",,Academic Press Inc.,426822,,VIRLA,31670218,English,Virology,Article,Final,Open Access,Scopus,2-s2.0-85073830902,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Lin C.-Y., Hwang D., Chiu N.-C., Weng L.-C., Liu H.-F., Mu J.-J., Liu C.-P., Chi H.",56180926100;57020673500;7006177196;7102793446;7409753240;7102233137;8376183000;7102258790;,Increased detection of viruses in children with respiratory tract infection using PCR,2020,International Journal of Environmental Research and Public Health,17,2,564,,,,,10.3390/ijerph17020564,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078049384&doi=10.3390%2fijerph17020564&partnerID=40&md5=9be26ea0b9b894cec6c1d0dec13712bb,"Department of Pediatrics, Hsinchu MacKay Memorial Hospital, Hsinchu, 30071, Taiwan; Department of Medicine, MacKay Medical College, New Taipei City, 25160, Taiwan; Department of Pediatrics, MacKay Children’s Hospital and MacKay Memorial Hospital, Taipei, 10449, Taiwan; Department of Medicine, MacKay Junior College of Medicine, Nursing and Management, Taipei, 11260, Taiwan; Department of Medical Research, MacKay Memorial Hospital, Tamshui, New Taipei City, 25160, Taiwan; Centers for Research, Diagnostics and Vaccine Development, Centers for Disease Control, Taipei, 10050, Taiwan","Lin, C.-Y., Department of Pediatrics, Hsinchu MacKay Memorial Hospital, Hsinchu, 30071, Taiwan, Department of Medicine, MacKay Medical College, New Taipei City, 25160, Taiwan; Hwang, D., Department of Pediatrics, MacKay Children’s Hospital and MacKay Memorial Hospital, Taipei, 10449, Taiwan; Chiu, N.-C., Department of Medicine, MacKay Medical College, New Taipei City, 25160, Taiwan, Department of Pediatrics, MacKay Children’s Hospital and MacKay Memorial Hospital, Taipei, 10449, Taiwan, Department of Medicine, MacKay Junior College of Medicine, Nursing and Management, Taipei, 11260, Taiwan; Weng, L.-C., Department of Medical Research, MacKay Memorial Hospital, Tamshui, New Taipei City, 25160, Taiwan; Liu, H.-F., Department of Medical Research, MacKay Memorial Hospital, Tamshui, New Taipei City, 25160, Taiwan; Mu, J.-J., Centers for Research, Diagnostics and Vaccine Development, Centers for Disease Control, Taipei, 10050, Taiwan; Liu, C.-P., Department of Medicine, MacKay Medical College, New Taipei City, 25160, Taiwan, Department of Medicine, MacKay Junior College of Medicine, Nursing and Management, Taipei, 11260, Taiwan, Department of Medical Research, MacKay Memorial Hospital, Tamshui, New Taipei City, 25160, Taiwan; Chi, H., Department of Medicine, MacKay Medical College, New Taipei City, 25160, Taiwan, Department of Pediatrics, MacKay Children’s Hospital and MacKay Memorial Hospital, Taipei, 10449, Taiwan, Department of Medicine, MacKay Junior College of Medicine, Nursing and Management, Taipei, 11260, Taiwan, Department of Medical Research, MacKay Memorial Hospital, Tamshui, New Taipei City, 25160, Taiwan","Respiratory viruses are a common cause of respiratory tract infection (RTI), particularly in neonates and children. Rapid and accurate diagnosis of viral infections could improve clinical outcomes and reduce the use of antibiotics and treatment sessions. Advances in diagnostic technology contribute to the accurate detection of viruses. We performed a multiplex real-time polymerase chain reaction (PCR) to investigate the viral etiology in pediatric patients and compared the detection rates with those determined using traditional antigen tests and virus cultures. Fifteen respiratory viruses were included in our investigation: respiratory syncytial virus A/B (RSV), influenza virus A (FluA) and influenza virus B (FluB), human metapneumovirus (MPV), enterovirus (EV), human parainfluenza virus (PIV) types 1–4, human rhinovirus (RV), human coronavirus OC43, NL63, and 229E, human adenovirus (ADV), and human bocavirus (Boca). In total, 474 specimens were collected and tested. Respiratory viruses were detected more frequently by PCR (357, 75.3%) than they were by traditional tests (229, 49.3%). The leading pathogens were RSV (113, 23.8%), RV (72, 15.2%), PIV3 (53, 11.2%), FluA (51, 10.8%), and ADV (48, 10.1%). For children younger than 5 years, RSV and RV were most prevalent; for children older than 5 years, FluA and ADV were the most frequently detected. Of the specimens, 25.8% (92/357) were coinfected with two or more viruses. RV, Boca, PIV2, FluB, and PIV4 had higher rates of coinfection; MPV and PIV1 had the lowest rates of coinfection (9.1% and 5.3%). To conclude, the detection power of PCR was better than that of traditional antigen tests and virus cultures when considering the detection of respiratory viruses. RSV and RV were the leading viral pathogens identified in the respiratory specimens. One-quarter of the positive specimens were coinfected with two or more viruses. In the future, further application of PCR may contribute to the rapid and accurate diagnosis of respiratory viruses and could improve patient outcomes. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.",Human metapneumovirus; Multiplex quantitative real-time RT-PCR; PCR; Polymerase chain reaction; Respiratory syncytial virus; Respiratory virus,child health; disease spread; environmental risk; health risk; medical geography; numerical model; polymerase chain reaction; quantitative analysis; respiratory disease; virus; age; animal cell; Article; child; controlled study; Enterovirus; human; Human adenovirus C; Human bocavirus; human cell; Human coronavirus 229E; Human coronavirus NL63; Human coronavirus OC43; Human metapneumovirus; Human parainfluenza virus 1; Human parainfluenza virus 2; Human parainfluenza virus 3; Human parainfluenza virus 4; Human respiratory syncytial virus; Human respiratory syncytial virus A; Human respiratory syncytial virus B; Human rhinovirus; infection rate; Influenza A virus; Influenza B virus; intermethod comparison; mixed infection; multiplex real time polymerase chain reaction; nonhuman; seasonal variation; viral respiratory tract infection; virus culture; virus detection; Coronavirus; Enterovirus; Human adenovirus; Human bocavirus; Human metapneumovirus; Human rhinovirus sp.; Influenzavirus A; Influenzavirus B; Moroccan pepper virus; parainfluenza virus; Respiratory syncytial virus; Rice stripe virus,"Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory infections in 195 countries, 1990–2016: A systematic analysis for the global burden of disease study 2016 (2018) Lancet Infect. 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Dis., 191, pp. 382-386; Xepapadaki, P., Psarras, S., Bossios, A., Tsolia, M., Gourgiotis, D., Liapi-Adamidou, G., Constantopoulos, A.G., Papadopoulos, N.G., Human metapneumovirus as a causative agent of acute bronchiolitis in infants (2004) J. Clin. Virol. Off. Publ. Pan Am. Soc. Clin. Virol., 30, pp. 267-270; Lau, S.K., Yip, C.C., Tsoi, H.W., Lee, R.A., So, L.Y., Lau, Y.L., Chan, K.H., Yuen, K.Y., Clinical features and complete genome characterization of a distinct human rhinovirus (HRV) genetic cluster, probably representing a previously undetected hrv species, hrv-c, associated with acute respiratory illness in children (2007) J. Clin. Microbiol., 45, pp. 3655-3664; Ma, Y.J., Wang, S.M., Cho, Y.H., Shen, C.F., Liu, C.C., Chi, H., Huang, Y.C., Lin, H.C., Clinical and epidemiological characteristics in children with community-acquired mycoplasma pneumonia in Taiwan: A nationwide surveillance (2015) J. Microbiol. Immunol. Infect., 48, pp. 632-638; Babakir-Mina, M., Ciccozzi, M., Perno, C.F., Ciotti, M., The human polyomaviruses ki and wu: Virological background and clinical implications (2013) APMIS Acta Pathol. Microbiol. Et Immunol. Scand., 121, pp. 746-754","Chi, H.; Department of Medicine, MacKay Medical CollegeTaiwan; email: chi.4531@mmh.org.tw",,MDPI AG,16617827,,,31952364,English,Int. J. Environ. Res. Public Health,Article,Final,Open Access,Scopus,2-s2.0-85078049384,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Wolff G.G.,56654834800;,Influenza vaccination and respiratory virus interference among Department of Defense personnel during the 2017–2018 influenza season,2020,Vaccine,38,2,,350,354,,,10.1016/j.vaccine.2019.10.005,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85073050258&doi=10.1016%2fj.vaccine.2019.10.005&partnerID=40&md5=dcd9414e02b7d6368409134149b3f2e0,"Armed Forces Health Surveillance Branch Air Force Satellite, 2510 5th Street, Bldg 840, Wright-Patterson AFBOH 45433, United States","Wolff, G.G., Armed Forces Health Surveillance Branch Air Force Satellite, 2510 5th Street, Bldg 840, Wright-Patterson AFBOH 45433, United States","Purpose: Receiving influenza vaccination may increase the risk of other respiratory viruses, a phenomenon known as virus interference. Test-negative study designs are often utilized to calculate influenza vaccine effectiveness. The virus interference phenomenon goes against the basic assumption of the test-negative vaccine effectiveness study that vaccination does not change the risk of infection with other respiratory illness, thus potentially biasing vaccine effectiveness results in the positive direction. This study aimed to investigate virus interference by comparing respiratory virus status among Department of Defense personnel based on their influenza vaccination status. Furthermore, individual respiratory viruses and their association with influenza vaccination were examined. Results: We compared vaccination status of 2880 people with non-influenza respiratory viruses to 3240 people with pan-negative results. Comparing vaccinated to non-vaccinated patients, the adjusted odds ratio for non-flu viruses was 0.97 (95% confidence interval (CI): 0.86, 1.09; p = 0.60). Additionally, the vaccination status of 3349 cases of influenza were compared to three different control groups: all controls (N = 6120), non-influenza positive controls (N = 2880), and pan-negative controls (N = 3240). The adjusted ORs for the comparisons among the three control groups did not vary much (range: 0.46–0.51). Conclusions: Receipt of influenza vaccination was not associated with virus interference among our population. Examining virus interference by specific respiratory viruses showed mixed results. Vaccine derived virus interference was significantly associated with coronavirus and human metapneumovirus; however, significant protection with vaccination was associated not only with most influenza viruses, but also parainfluenza, RSV, and non-influenza virus coinfections. © 2019",Department of Defense; Influenza vaccine; Respiratory illness; Virus interference,influenza vaccine; adolescent; adult; Article; child; clinical protocol; comparative study; controlled study; disease association; drug efficacy; female; government; groups by age; human; infant; infection risk; influenza; influenza vaccination; major clinical study; male; newborn; priority journal; respiratory virus; virus interference,"(2019), https://www.nvic.org/vaccines-and-diseases/influenza/vaccine-history.aspx, National Vaccine Information Center. What is the History of Influenza Vaccine Use in America? <>; Treanor, J.J., Talbot, H.K., Ohmit, S.E., Effectiveness of seasonal influenza vaccines in the United States during a season with circulation of all three vaccine strains (2012) Clin Infect Dis, 55 (7), pp. 951-959; Ohmit, S.E., Thompson, M.G., Petrie, J.G., Influenza vaccine effectiveness in the 2011–2012 season: protection against each circulating virus and the effect of prior vaccination on estimates (2014) Clin Infect Dis, 58 (3), pp. 319-327; McLean, H.Q., Thompson, M.G., Sundaram, M.E., Influenza vaccine effectiveness in the United States during 2012–2013: variable protection by age and virus type (2015) J Infect Dis, 211 (10), pp. 1529-1540; Jackson, M.L., Chung, J.R., Jackson, L.A., Influenza Vaccine Effectiveness in the United States during the 2015–2016 Season (2017) N Engl J Med, 377 (6), pp. 534-543; (2019), https://www.cdc.gov/flu/professionals/vaccination/effectiveness-studies.htm, Centers for Disease Control and Prevention. Seasonal Influenza Vaccine Effectiveness, 2004-2018. <> 22 February; Suzuki, M., Camacho, A., Ariyoshi, K., Potential effect of virus interference on influenza vaccine effectiveness estimates in test-negative designs (2014) Epidemiol Infect, 142, pp. 2642-2646; Cowling, B.J., Fang, V.J., Peiris, J.S.M., Increased risk of noninfluenza respiratory virus infections associated with receipt of inactivated influenza vaccine (2012) Clin Infect Dis, 54, pp. 1778-1783; Feng, S., Fowlkes, A., Steffens, A., Finelli, L., Cowling, B., Assessment of virus interference in a test-negative study of influenza vaccine effectiveness (2017) Epidemiology, 28 (4), pp. 514-524; Cowling, B.J., Nishiura, H., Virus interference and estimates of influenza vaccine effectiveness from test-negative studies (2012) Epidemiology., 23 (6), pp. 930-931; Rikin, S., Jia, H., Stockwell, M., Assessment of temporally-related acute respiratory illness following influenza vaccination (2018) Vaccine, 36, pp. 1958-1964; Sundaram, M.E., McClure, D.L., Belongia, E.A., Influenza vaccination is not associated with detection of noninfluenza respiratory viruses in seasonal studies of influenza vaccine effectiveness (2013) Clin Infect Dis, 57, pp. 789-793; Defense Health Agency, Seasonal Influenza Vaccination Program (IVP) (2018), pp. 1-23. , Defense Health Agency Falls Church, Virginia Interim Procedures Memorandum 18-005; (2016), NxTAG Respiratory Pathogen Panel [package insert]. Toronto, Ontario, Canada: Luminex;; (2017), Biofire FilmArray Respiratory Pathogen Panel [package insert]. Salt Lake City, Utah, USA; 28 June; (2016), CDC Influenza A Subtyping Kit (Version 2) [package insert]. Atlanta, Georgia, USA; 22 July; (2016), CDC Influenza A/B Subtyping Kit [package insert]. Atlanta, Georgia, USA; 23 March; Foppa, I., Haber, M., Ferdinands, J., The case test-negative design for studies of the effectiveness of influenza vaccine (2013) Vaccine, 31 (June), pp. 3104-3109; Jackson, M., Nelson, J., The test-negative design for estimating influenza vaccine effectiveness (2013) Vaccine, 31 (April), pp. 2165-2168; Foppa, I., Ferdinands, J., Chaves, S., The case test-negative design for studies of the effectiveness of influenza vaccine in inpatient settings (2016) Int J Epidemiol, 6, p. 2052; Sullivan, S., Tchetgen Tchetgen, E., Cowling, B., Theoretical basis of the test-negative study design for assessment of influenza vaccine effectiveness (2016) Am J Epidemiol, 5, p. 345; Coleman, R., Eick-Cost, A., Hawksworth, A.W., Department of defense end-of-season influenza vaccine effectiveness estimates for the 2017–2018 season (2018) MSMR, 25 (10), p. 16; Cooper, M., (2014), DoD Influenza Surveillance and Vaccine Effectiveness. In: Oral presentation at: The Vaccines and Related Biological Products Advisory Committee (VRBPAC) Meeting; February 28 Silver Spring, MD",,,Elsevier Ltd,0264410X,,VACCD,31607599,English,Vaccine,Article,Final,Open Access,Scopus,2-s2.0-85073050258,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Sungsuwan S., Jongkaewwattana A., Jaru-Ampornpan P.",36195208800;25824320100;16744130800;,Nucleocapsid proteins from other swine enteric coronaviruses differentially modulate PEDV replication,2020,Virology,540,,,45,56,,1,10.1016/j.virol.2019.11.007,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85074849304&doi=10.1016%2fj.virol.2019.11.007&partnerID=40&md5=8a29a8a84b492b575bd73c81fa011385,"Virology and Cell Technology Research Team, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA)Pathum Thani 12120, Thailand","Sungsuwan, S., Virology and Cell Technology Research Team, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA)Pathum Thani 12120, Thailand; Jongkaewwattana, A., Virology and Cell Technology Research Team, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA)Pathum Thani 12120, Thailand; Jaru-Ampornpan, P., Virology and Cell Technology Research Team, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA)Pathum Thani 12120, Thailand","Porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV) and porcine deltacoronavirus (PDCoV) share tropism for swine intestinal epithelial cells. Whether mixing of viral components during co-infection alters pathogenic outcomes or viral replication is not known. In this study, we investigated how different coronavirus nucleocapsid (CoV N) proteins interact and affect PEDV replication. We found that PDCoV N and TGEV N can competitively interact with PEDV N. However, the presence of PDCoV or TGEV N led to very different outcomes on PEDV replication. While PDCoV N significantly suppresses PEDV replication, overexpression of TGEV N, like that of PEDV N, increases production of PEDV RNA and virions. Despite partial interchangeability in nucleocapsid oligomerization and viral RNA synthesis, endogenous PEDV N cannot be replaced in the production of infectious PEDV particles. Results from this study give insights into functional compatibilities and evolutionary relationship between CoV viral proteins during viral co-infection and co-evolution. © 2019",Nucleocapsid protein; Porcine epidemic diarrhea virus; Swine coronavirus,nucleocapsid protein; virus RNA; Article; coevolution; controlled study; Coronavirinae; gene overexpression; human; human cell; mixed infection; nonhuman; oligomerization; porcine deltacoronavirus; Porcine epidemic diarrhea virus; priority journal; protein protein interaction; RNA synthesis; Transmissible gastroenteritis virus; virion; virus particle; virus replication,"Aoki, H., Nishiyama, Y., Tsurumi, T., Shibata, M., Ito, Y., Seo, H., Yoshii, S., Maeno, K., Mechanism of interference between influenza A/WSN and B/Kanagawa viruses (1984) J. Gen. 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Wickner Academic Press New York, N.Y; Fan, H., Ooi, A., Tan, Y.W., Wang, S., Fang, S., Liu, D.X., Lescar, J., (2005) The Nucleocapsid Protein of Coronavirus Infectious Bronchitis Virus: Crystal Structure of its N-Terminal Domain and Multimerization Properties, 13, pp. 1859-1868. , Structure London, England 1993; Fang, P., Fang, L., Hong, Y., Liu, X., Dong, N., Ma, P., Bi, J., Xiao, S., Discovery of a novel accessory protein NS7a encoded by porcine deltacoronavirus (2017) J. Gen. Virol., 98, pp. 173-178; Gimenez-Lirola, L.G., Zhang, J., Carrillo-Avila, J.A., Chen, Q., Magtoto, R., Poonsuk, K., Baum, D.H., Zimmerman, J., Reactivity of porcine epidemic diarrhea virus structural proteins to antibodies against porcine enteric coronaviruses: Diagnostic implications (2017) J. Clin. Microbiol., 55, pp. 1426-1436; He, R., Dobie, F., Ballantine, M., Leeson, A., Li, Y., Bastien, N., Cutts, T., Li, X., Analysis of multimerization of the SARS coronavirus nucleocapsid protein (2004) Biochem. 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Sci., 25, p. 47; Huang, Q., Yu, L., Petros, A.M., Gunasekera, A., Liu, Z., Xu, N., Hajduk, P., Olejniczak, E.T., Structure of the N-terminal RNA-binding domain of the SARS CoV nucleocapsid protein (2004) Biochemistry, 43, pp. 6059-6063; Hurst, K.R., Koetzner, C.A., Masters, P.S., Characterization of a critical interaction between the coronavirus nucleocapsid protein and nonstructural protein 3 of the viral replicase-transcriptase complex (2013) J. Virol., 87, pp. 9159-9172; Hurst, K.R., Kuo, L., Koetzner, C.A., Ye, R., Hsue, B., Masters, P.S., A major determinant for membrane protein interaction localizes to the carboxy-terminal domain of the mouse coronavirus nucleocapsid protein (2005) J. Virol., 79, pp. 13285-13297; Hurst, K.R., Ye, R., Goebel, S.J., Jayaraman, P., Masters, P.S., An interaction between the nucleocapsid protein and a component of the replicase-transcriptase complex is crucial for the infectivity of coronavirus genomic RNA (2010) J. 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Virol., 84, pp. 2169-2175; Zuniga, S., Sola, I., Moreno, J.L., Sabella, P., Plana-Duran, J., Enjuanes, L., Coronavirus nucleocapsid protein is an RNA chaperone (2007) Virology, 357, pp. 215-227","Jaru-Ampornpan, P.; Virology and Cell Technology Research Team, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA)Thailand; email: peera.jar@biotec.or.th",,Academic Press Inc.,426822,,VIRLA,31756532,English,Virology,Article,Final,Open Access,Scopus,2-s2.0-85074849304,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Chen R., Fu J., Hu J., Li C., Zhao Y., Qu H., Wen X., Cao S., Wen Y., Wu R., Zhao Q., Yan Q., Huang Y., Ma X., Han X., Huang X.",57211968806;57211966467;57211967395;57211964624;57211969827;57211966200;26031746800;26031318600;55693768900;55951453600;55743369600;40162567400;56923887700;55838578000;56467562100;54412415500;,Identification of the immunodominant neutralizing regions in the spike glycoprotein of porcine deltacoronavirus,2020,Virus Research,276,,197834,,,,2,10.1016/j.virusres.2019.197834,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85076171586&doi=10.1016%2fj.virusres.2019.197834&partnerID=40&md5=e229e6ad4dec2d713e5c1e94885b78d6,"Research Center for Swine Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China; Sichuan Science-Observation Experimental Station for Veterinary Drugs and Veterinary Diagnostic Technology, Ministry of Agriculture, Chengdu, 611130, China; National Animal Experiment Teaching Demonstration Center, Sichuan Agricultural University, Chengdu, 611130, China","Chen, R., Research Center for Swine Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China; Fu, J., Research Center for Swine Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China; Hu, J., Research Center for Swine Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China; Li, C., Research Center for Swine Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China; Zhao, Y., Research Center for Swine Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China; Qu, H., Research Center for Swine Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China; Wen, X., Research Center for Swine Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China; Cao, S., Research Center for Swine Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China, Sichuan Science-Observation Experimental Station for Veterinary Drugs and Veterinary Diagnostic Technology, Ministry of Agriculture, Chengdu, 611130, China, National Animal Experiment Teaching Demonstration Center, Sichuan Agricultural University, Chengdu, 611130, China; Wen, Y., Research Center for Swine Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China; Wu, R., Research Center for Swine Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China; Zhao, Q., Research Center for Swine Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China; Yan, Q., Sichuan Science-Observation Experimental Station for Veterinary Drugs and Veterinary Diagnostic Technology, Ministry of Agriculture, Chengdu, 611130, China; Huang, Y., Sichuan Science-Observation Experimental Station for Veterinary Drugs and Veterinary Diagnostic Technology, Ministry of Agriculture, Chengdu, 611130, China; Ma, X., Sichuan Science-Observation Experimental Station for Veterinary Drugs and Veterinary Diagnostic Technology, Ministry of Agriculture, Chengdu, 611130, China; Han, X., Sichuan Science-Observation Experimental Station for Veterinary Drugs and Veterinary Diagnostic Technology, Ministry of Agriculture, Chengdu, 611130, China; Huang, X., Research Center for Swine Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, 611130, China, Sichuan Science-Observation Experimental Station for Veterinary Drugs and Veterinary Diagnostic Technology, Ministry of Agriculture, Chengdu, 611130, China, National Animal Experiment Teaching Demonstration Center, Sichuan Agricultural University, Chengdu, 611130, China","Porcine deltacoronavirus (PDCoV), is an emerging enteropathogenic coronavirus in pigs, that poses a novel threat to swine husbandry worldwide. Crucial to halting PDCoV transmission and infection is the development of effective therapies and vaccines. The spike (S) protein of coronavirus is the major target of host neutralizing antibodies, however the immunodominant neutralizing region in the S protein of PDCoV has not been defined. Here, three truncations of the PDCoV S protein were generated, the N-terminal domain of the S1 subunit (NTD, amino acids (aa) 50–286), the C-terminal domain of the S1 subunit (CTD, aa 278–616), and S2 subunit (aa 601–1087). The proteins were expressed using an E. coli expression system. Polyclonal antisera against the three recombinant proteins were produced in rabbits and mice. All three antisera were able to inhibit PDCoV infection in vitro, as determined by virus neutralization assay, fluorescent focus neutralization assay, and plaque-reduction neutralization. The CTD-specific antisera had the most potent PDCoV-neutralizing effect, indicating that the CTD region may contain the major neutralizing epitope(s) in the PDCoV S protein. Based on these findings, CTD may be a promising target for development of an effective vaccine against PDCoV infection in pigs. © 2019 Elsevier B.V.",Epitope region; Neutralizing antibody; Porcine deltacoronavirus (PDCoV); Spike glycoprotein,amino acid; epitope; immunoglobulin G antibody; neutralizing antibody; polyclonal antibody; recombinant protein; virus spike protein; affinity chromatography; amino terminal sequence; animal experiment; animal model; Article; carboxy terminal sequence; controlled study; Coronavirinae; Coronavirus infection; Deltacoronavirus; Escherichia coli; female; gene expression system; humoral immunity; immunogenicity; mouse; nonhuman; pig; polyacrylamide gel electrophoresis; priority journal; virus identification; virus neutralization; Western blotting,"Chen, Y., Lu, S., Jia, H., Deng, Y., Zhou, J., Huang, B., Yu, Y., Tan, W., A novel neutralizing monoclonal antibody targeting the N-terminal domain of the MERS-CoV spike protein (2017) Emerg. 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Genetics Evol., 61, pp. 176-182; Tai, W., Wang, Y., Fett, C.A., Zhao, G., Li, F., Perlman, S., Jiang, S., Du, L., Recombinant receptor-binding domains of multiple middle east respiratory syndrome coronaviruses (MERS-CoVs) induce cross-neutralizing antibodies against divergent human and camel MERS-CoVs and antibody escape mutants (2017) J. Virol., 91 (1); Tumpey, T.M., García-Sastre, A., Taubenberger, J.K., Palese, P., Swayne, D.E., Pantin-Jackwood, M.J., Schultz-Cherry, S., Basler, C.F., Pathogenicity of influenza viruses with genes from the 1918 pandemic virus: functional roles of alveolar macrophages and neutrophils in limiting virus replication and mortality in mice (2005) J. Virol., 79 (23), pp. 14933-14944; Wang, B., Liu, Y., Ji, C.M., Yang, Y.L., Liang, Q.Z., Zhao, P., Xu, L.D., Huang, Y.W., Porcine deltacoronavirus engages the transmissible gastroenteritis virus functional receptor porcine aminopeptidase N for infectious cellular entry (2018) J. Virol., 92 (12), pp. e00318-00318; Wang, L., Byrum, B., Zhang, Y., Detection and genetic characterization of deltacoronavirus in pigs, Ohio, USA, 2014 (2014) Emerg. Infect. Dis., 20 (7), pp. 1227-1230; Wang, L., Byrum, B., Zhang, Y., Porcine coronavirus HKU15 detected in 9 US states, 2014 (2014) Emerg. Infect. Dis., 20 (9), pp. 1594-1595; Woo, P.C., Lau, S.K., Lam, C.S., Lau, C.C., Tsang, A.K., Lau, J.H., Bai, R., Yuen, K.Y., Discovery of seven novel Mammalian and avian coronaviruses in the genus deltacoronavirus supports bat coronaviruses as the gene source of alphacoronavirus and betacoronavirus and avian coronaviruses as the gene source of gammacoronavirus and deltacoronavirus (2012) J. Virol., 86 (7), pp. 3995-4008; Xiong, X., Tortorici, M.A., Snijder, J., Yoshioka, C., Walls, A.C., Li, W., McGuire, A.T., Veesler, D., Glycan shield and fusion activation of a deltacoronavirus spike glycoprotein fine-tuned for enteric infections (2018) J. Virol., 92 (4), pp. e01628-01617; Yoo, D., Deregt, D., A single amino acid change within antigenic domain II of the spike protein of bovine coronavirus confers resistance to virus neutralization (2001) Clin. Diagn. Lab. Immunol., 8 (2), pp. 297-302; Zhang, J., Porcine deltacoronavirus: overview of infection dynamics, diagnostic methods, prevalence and genetic evolution (2016) Virus Res., 226, pp. 71-84; Zhu, X., Liu, S., Wang, X., Luo, Z., Shi, Y., Wang, D., Peng, G., Xiao, S., Contribution of porcine aminopeptidase N to porcine deltacoronavirus infection (2018) Emerg. Microbes Infect., 7 (1), p. 65; Zumla, A., Chan, J.F., Azhar, E.I., Hui, D.S., Yuen, K.Y., Coronaviruses - drug discovery and therapeutic options. Nature reviews (2016) Drug Discov., 15 (5), pp. 327-347","Huang, X.; Research Center for Swine Diseases, College of Veterinary Medicine, Sichuan Agricultural UniversityChina; email: rsghb110@126.com",,Elsevier B.V.,1681702,,VIRED,31816342,English,Virus Res.,Article,Final,Open Access,Scopus,2-s2.0-85076171586,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Parry J.,24605791400;,China coronavirus: cases surge as official admits human to human transmission,2020,BMJ (Clinical research ed.),368,,,m236,,,2,10.1136/bmj.m236,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078547442&doi=10.1136%2fbmj.m236&partnerID=40&md5=a2f7be13cd1b7ca563b1f9b1e8514554,"Hamilton, Canada","Parry, J., Hamilton, Canada",[No abstract available],,,,,,NLM (Medline),17561833,,,31959587,English,BMJ,Article,Final,Open Access,Scopus,2-s2.0-85078547442,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Li E., Yan F., Huang P., Chi H., Xu S., Li G., Liu C., Feng N., Wang H., Zhao Y., Yang S., Xia X.",57193533169;56959769400;57193760636;57215596757;57202300647;57196354857;57210893186;35175960300;36487256300;55199696000;57215371793;12787855600;,Characterization of the Immune Response of MERS-CoV Vaccine Candidates Derived from Two Different Vectors in Mice,2020,Viruses,12,1,,,,,1,10.3390/v12010125,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078222535&doi=10.3390%2fv12010125&partnerID=40&md5=9a1e0d84a9dde7d361c5bfe6fe02d94c,"College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China; Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, 130122, China; Animal Science and Technology College, Jilin Agricultural University, Changchun, 130118, China; College of Animal Science and Technology, Shihezi University, China; College of Veterinary Medicine, Jilin University, Changchun, 130062, China; Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonosis, Yangzhou University, Yangzhou, 225009, China","Li, E., College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, 130122, China; Yan, F., Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, 130122, China; Huang, P., Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, 130122, China, Animal Science and Technology College, Jilin Agricultural University, Changchun, 130118, China; Chi, H., Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, 130122, China; Xu, S., Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, 130122, China, Animal Science and Technology College, Jilin Agricultural University, Changchun, 130118, China; Li, G., Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, 130122, China, College of Animal Science and Technology, Shihezi University, China; Liu, C., Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, 130122, China, Animal Science and Technology College, Jilin Agricultural University, Changchun, 130118, China; Feng, N., Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, 130122, China; Wang, H., College of Veterinary Medicine, Jilin University, Changchun, 130062, China; Zhao, Y., Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, 130122, China; Yang, S., Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, 130122, China; Xia, X., College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China, Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, 130122, China, Animal Science and Technology College, Jilin Agricultural University, Changchun, 130118, China, College of Animal Science and Technology, Shihezi University, China, College of Veterinary Medicine, Jilin University, Changchun, 130062, China, Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonosis, Yangzhou University, Yangzhou, 225009, China","Middle East respiratory syndrome (MERS) is an acute, high-mortality-rate, severe infectious disease caused by an emerging MERS coronavirus (MERS-CoV) that causes severe respiratory diseases. The continuous spread and great pandemic potential of MERS-CoV make it necessarily important to develop effective vaccines. We previously demonstrated that the application of Gram-positive enhancer matrix (GEM) particles as a bacterial vector displaying the MERS-CoV receptor-binding domain (RBD) is a very promising MERS vaccine candidate that is capable of producing potential neutralization antibodies. We have also used the rabies virus (RV) as a viral vector to design a recombinant vaccine by expressing the MERS-CoV S1 (spike) protein on the surface of the RV. In this study, we compared the immunological efficacy of the vaccine candidates in BALB/c mice in terms of the levels of humoral and cellular immune responses. The results show that the rabies virus vector-based vaccine can induce remarkably earlier antibody response and higher levels of cellular immunity than the GEM particles vector. However, the GEM particles vector-based vaccine candidate can induce remarkably higher antibody response, even at a very low dose of 1 µg. These results indicate that vaccines constructed using different vaccine vector platforms for the same pathogen have different rates and trends in humoral and cellular immune responses in the same animal model. This discovery not only provides more alternative vaccine development platforms for MERS-CoV vaccine development, but also provides a theoretical basis for our future selection of vaccine vector platforms for other specific pathogens.",bacterium-like particle; immune response; MERS-CoV; recombinant rabies virus,,,,,NLM (Medline),19994915,,,31968702,English,Viruses,Article,Final,Open Access,Scopus,2-s2.0-85078222535,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Yang T.-J., Chang Y.-C., Ko T.-P., Draczkowski P., Chien Y.-C., Chang Y.-C., Wu K.-P., Khoo K.-H., Chang H.-W., Danny Hsu S.-T.",57202549507;57194287068;7201681318;55872877200;57214097396;23466271800;57214077799;57214096321;56133800800;23027574700;,Cryo-EM analysis of a feline coronavirus spike protein reveals a unique structure and camouflaging glycans,2020,Proceedings of the National Academy of Sciences of the United States of America,117,3,,1438,1446,,,10.1073/pnas.1908898117,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078201355&doi=10.1073%2fpnas.1908898117&partnerID=40&md5=ecd005d258bbba8c9dcc5818197337fb,"Institute of Biological Chemistry, Academia Sinica, Taipei, 11529, Taiwan; Institute of Biochemical Sciences, National Taiwan University, Taipei, 10617, Taiwan; Graduate Institute of Molecular and Comparative Pathobiology, School of Veterinary Medicine, National Taiwan University, Taipei, 10617, Taiwan; Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, 11529, Taiwan","Yang, T.-J., Institute of Biological Chemistry, Academia Sinica, Taipei, 11529, Taiwan, Institute of Biochemical Sciences, National Taiwan University, Taipei, 10617, Taiwan; Chang, Y.-C., Institute of Biological Chemistry, Academia Sinica, Taipei, 11529, Taiwan, Graduate Institute of Molecular and Comparative Pathobiology, School of Veterinary Medicine, National Taiwan University, Taipei, 10617, Taiwan; Ko, T.-P., Institute of Biological Chemistry, Academia Sinica, Taipei, 11529, Taiwan; Draczkowski, P., Institute of Biological Chemistry, Academia Sinica, Taipei, 11529, Taiwan; Chien, Y.-C., Institute of Biological Chemistry, Academia Sinica, Taipei, 11529, Taiwan, Institute of Biochemical Sciences, National Taiwan University, Taipei, 10617, Taiwan; Chang, Y.-C., Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, 11529, Taiwan; Wu, K.-P., Institute of Biological Chemistry, Academia Sinica, Taipei, 11529, Taiwan; Khoo, K.-H., Institute of Biological Chemistry, Academia Sinica, Taipei, 11529, Taiwan, Institute of Biochemical Sciences, National Taiwan University, Taipei, 10617, Taiwan; Chang, H.-W., Graduate Institute of Molecular and Comparative Pathobiology, School of Veterinary Medicine, National Taiwan University, Taipei, 10617, Taiwan; Danny Hsu, S.-T., Institute of Biological Chemistry, Academia Sinica, Taipei, 11529, Taiwan, Institute of Biochemical Sciences, National Taiwan University, Taipei, 10617, Taiwan","Feline infectious peritonitis virus (FIPV) is an alphacoronavirus that causes a nearly 100% mortality rate without effective treatment. Here we report a 3.3-Å cryoelectron microscopy (cryo-EM) structure of the serotype I FIPV spike (S) protein, which is responsible for host recognition and viral entry. Mass spectrometry provided site-specific compositions of densely distributed high-mannose and complex-type N-glycans that account for 1/4 of the total molecular mass; most of the N-glycans could be visualized by cryo-EM. Specifically, the N-glycans that wedge between 2 galectin-like domains within the S1 subunit of FIPV S protein result in a unique propeller-like conformation, underscoring the importance of glycosylation in maintaining protein structures. The cleavage site within the S2 subunit responsible for activation also showed distinct structural features and glycosylation. These structural insights provide a blueprint for a bettermolecular understanding of the pathogenesis of FIP. © 2020 National Academy of Sciences. All rights reserved.",Alphacoronavirus; Cryoelectron microscopy; Feline infectious peritonitis virus; Mass spectrometry; Protein glycosylation,glycan; virus spike protein; animal experiment; Article; binding site; conformation; controlled study; cryoelectron microscopy; Feline infectious peritonitis virus; glycosylation; host interaction; human; human cell; mass spectrometry; mouse; nonhuman; pathogenesis; priority journal; protein analysis; protein cleavage; protein structure; virus entry; virus strain,"Millet, J.K., Whittaker, G.R., Host cell proteases: Critical determinants of coronavirus tropism and pathogenesis (2015) Virus Res., 202, pp. 120-134; Jaimes, J.A., Whittaker, G.R., Feline coronavirus: Insights into viral pathogenesis based on the spike protein structure and function (2018) Virology, 517, pp. 108-121; Yuan, Y., Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains (2017) Nat. 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U.S.A., 99, pp. 9611-9613; Carbone, F.R., Gleeson, P.A., Carbohydrates and antigen recognition by T cells (1997) Glycobiology, 7, pp. 725-730; Speir, J.A., Abdel-Motal, U.M., Jondal, M., Wilson, I.A., Crystal structure of an MHC class I presented glycopeptide that generates carbohydrate-specific CTL (1999) Immunity, 10, pp. 51-61; Dimitrov, J.D., Kazatchkine, M.D., Kaveri, S.V., Lacroix-Desmazes, S., ""Rational vaccine design"" for HIV should take into account the adaptive potential of polyreactive antibodies (2011) PLoS Pathog., 7, p. e1002095","Danny Hsu, S.-T.; Institute of Biological Chemistry, Academia SinicaTaiwan; email: sthsu@gate.sinica.edu.tw",,National Academy of Sciences,278424,,PNASA,31900356,English,Proc. Natl. Acad. Sci. U. S. A.,Article,Final,Open Access,Scopus,2-s2.0-85078201355,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Qian S., Gao Z., Cao R., Yang K., Cui Y., Li S., Meng X., He Q., Li Z.",57190955728;57213588787;57214749487;57214753982;57211202706;23393297400;36461551400;7402117843;35305208200;,Transmissible Gastroenteritis Virus Infection Up-Regulates FcRn Expression via Nucleocapsid Protein and Secretion of TGF-β in Porcine Intestinal Epithelial Cells,2020,Frontiers in Microbiology,10,,3085,,,,,10.3389/fmicb.2019.03085,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079051712&doi=10.3389%2ffmicb.2019.03085&partnerID=40&md5=93d6a050dda441544bcdb31311013ce1,"State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China; Key Laboratory of Development of Veterinary Diagnostic Products, Ministry of Agriculture of the People’s Republic of China, Wuhan, China","Qian, S., State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China; Gao, Z., State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China; Cao, R., State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China; Yang, K., State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China; Cui, Y., State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China; Li, S., State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China, Key Laboratory of Development of Veterinary Diagnostic Products, Ministry of Agriculture of the People’s Republic of China, Wuhan, China; Meng, X., State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China, Key Laboratory of Development of Veterinary Diagnostic Products, Ministry of Agriculture of the People’s Republic of China, Wuhan, China; He, Q., State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China, Key Laboratory of Development of Veterinary Diagnostic Products, Ministry of Agriculture of the People’s Republic of China, Wuhan, China; Li, Z., State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China, Key Laboratory of Development of Veterinary Diagnostic Products, Ministry of Agriculture of the People’s Republic of China, Wuhan, China","Transmissible gastroenteritis virus (TGEV) is a porcine intestinal coronavirus that causes fatal severe watery diarrhea in piglets. The neonatal Fc receptor (FcRn) is the only IgG transport receptor, its expression on mucosal surfaces is triggered upon viral stimulation, which significantly enhances mucosal immunity. We utilized TGEV as a model pathogen to explore the role of FcRn in resisting viral invasion in overall intestinal mucosal immunity. TGEV induced FcRn expression by activating NF-κB signaling in porcine small intestinal epithelial (IPEC-J2) cells, however, the underlying mechanisms are unclear. First, using small interfering RNAs, we found that TGEV up-regulated FcRn expression via TLR3, TLR9 and RIG-I. Moreover, TGEV induced IL-1β, IL-6, IL-8, TGF-β, and TNF-α production. TGF-β-stimulated IPEC-J2 cells highly up-regulated FcRn expression, while treatment with a JNK-specific inhibitor down-regulated the expression. TGEV nucleocapsid (N) protein also enhanced FcRn promoter activity via the NF-κB signaling pathway and its central region (aa 128–252) was essential for FcRn activation. Additionally, N protein-mediated FcRn up-regulation promotes IgG transcytosis. Thus, TGEV N protein and TGF-β up-regulated FcRn expression, further clarifying the molecular mechanism of up-regulation of FcRn expression by TGEV. © Copyright © 2020 Qian, Gao, Cao, Yang, Cui, Li, Meng, He and Li.",neonatal Fc receptor; NF-κB; nucleocapsid protein; TGF-β; toll-like receptor; transmissible gastroenteritis virus,,"An, K., Fang, L., Luo, R., Wang, D., Xie, L., Yang, J., Quantitative proteomic analysis reveals that transmissible gastroenteritis virus activates the JAK-STAT1 signaling pathway (2014) J. Proteome Res, 13, pp. 5376-5390. , 25357264; Arce, C., Ramirez-Boo, M., Lucena, C., Garrido, J.J., Innate immune activation of swine intestinal epithelial cell lines (IPEC-J2 and IPI-2I) in response to LPS from Salmonella typhimurium (2010) Comp. Immunol. Microbiol. Infect. 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Sci, 119, pp. 109-115. , 29909129; Zhang, X., Shi, H., Chen, J., Shi, D., Dong, H., Feng, L., Identification of the interaction between vimentin and nucleocapsid protein of transmissible gastroenteritis virus (2015) Virus Res, 200, pp. 56-63. , 25533531; Zhang, X., Shi, H., Chen, J., Shi, D., Li, C., Feng, L., EF1A interacting with nucleocapsid protein of transmissible gastroenteritis coronavirus and plays a role in virus replication (2014) Vet. Microbiol, 172, pp. 443-448. , 24974120; Zhang, X., Wu, K., Wang, D., Yue, X., Song, D., Zhu, Y., Nucleocapsid protein of SARS-CoV activates interleukin-6 expression through cellular transcription factor NF-kappaB (2007) Virology, 365, pp. 324-335. , 17490702; Zhao, S., Gao, J., Zhu, L., Yang, Q., Transmissible gastroenteritis virus and porcine epidemic diarrhoea virus infection induces dramatic changes in the tight junctions and microfilaments of polarized IPEC-J2 cells (2014) Virus Res, 192, pp. 34-45. , 25173696; Zhou, Y., Wu, W., Xie, L., Wang, D., Ke, Q., Hou, Z., Cellular RNA helicase DDX1 is involved in transmissible gastroenteritis virus nsp14-induced interferon-beta production (2017) Front. Immunol, 8 (940). , 28848548","Li, Z.; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural UniversityChina; email: lizili@mail.hzau.edu.cn",,Frontiers Media S.A.,1664302X,,,,English,Front. Microbiol.,Article,Final,Open Access,Scopus,2-s2.0-85079051712,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Liu S.-L., Saif L.",57215218926;7102226747;,Emerging Viruses without Borders: The Wuhan Coronavirus,2020,Viruses,12,2,,,,,4,10.3390/v12020130,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078228768&doi=10.3390%2fv12020130&partnerID=40&md5=f220a4156bb63b04a824291f153b8d15,"Center for Retrovirus Research, The Ohio State University, Columbus, OH 43210, USA; Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH 43210, USA; Viruses and Emerging Pathogens Program, Infectious Diseases Institute, The Ohio State University, Columbus, OH 43210, USA; Food Animal Health Research Program, The Ohio Agricultural Research and Development Center, College of Food, Agriculture and Environmental Sciences, The Ohio State University, Wooster, OH 43210, USA; Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Wooster, OH 43210, USA","Liu, S.-L., Center for Retrovirus Research, The Ohio State University, Columbus, OH 43210, USA, Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA, Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH 43210, USA, Viruses and Emerging Pathogens Program, Infectious Diseases Institute, The Ohio State University, Columbus, OH 43210, USA; Saif, L., Viruses and Emerging Pathogens Program, Infectious Diseases Institute, The Ohio State University, Columbus, OH 43210, USA, Food Animal Health Research Program, The Ohio Agricultural Research and Development Center, College of Food, Agriculture and Environmental Sciences, The Ohio State University, Wooster, OH 43210, USA, Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Wooster, OH 43210, USA","The recently emerged coronavirus in Wuhan, China has claimed at least two lives as of January 17 and infected hundreds if not thousands of individuals. The situation has drawn international attention, including from the virology community. We applaud the rapid release to the public of the genome sequence of the new virus by Chinese virologists, but we also believe that increased transparency on disease reporting and data sharing with international colleagues are crucial for curbing the spread of this newly emerging virus to other parts of the world.",,"COVID-19; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; China; communicable disease; Coronavirus infection; genetics; human; information dissemination; international cooperation; virology; virus genome; virus pneumonia; Betacoronavirus; China; Communicable Diseases, Emerging; Coronavirus Infections; Genome, Viral; Humans; Information Dissemination; International Cooperation; Pneumonia, Viral",,,,NLM (Medline),19994915,,,31979013,English,Viruses,Editorial,Final,Open Access,Scopus,2-s2.0-85078228768,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Mahase E.,57208387961;,Coronavirus: UK screens direct flights from Wuhan after US case,2020,BMJ (Clinical research ed.),368,,,m265,,,,10.1136/bmj.m265,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078287139&doi=10.1136%2fbmj.m265&partnerID=40&md5=3f65ab75c7f2fddf92ee537b46517514,BMJ,"Mahase, E., BMJ",[No abstract available],,,,,,NLM (Medline),17561833,,,31969317,English,BMJ,Article,Final,Open Access,Scopus,2-s2.0-85078287139,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Li S., Yuan L., Dai G., Chen R.A., Liu D.X., Fung T.S.",57214805866;57214795245;57214799874;53981013500;57190128771;55795740300;,"Regulation of the ER Stress Response by the Ion Channel Activity of the Infectious Bronchitis Coronavirus Envelope Protein Modulates Virion Release, Apoptosis, Viral Fitness, and Pathogenesis",2020,Frontiers in Microbiology,10,,3022,,,,,10.3389/fmicb.2019.03022,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079135665&doi=10.3389%2ffmicb.2019.03022&partnerID=40&md5=d0f2adfb2d451cc33cbb67cb6e889d9b,"Guangdong Province Key Laboratory of Microbial Signals Disease Control, Integrative Microbiology Research Centre, South China Agricultural University, Guangzhou, China; College of Veterinary Medicine, South China Agricultural University, Guangzhou, China; Zhaoqing DaHuaNong Biology Medicine Co., Ltd, Zhaoqing, China","Li, S., Guangdong Province Key Laboratory of Microbial Signals Disease Control, Integrative Microbiology Research Centre, South China Agricultural University, Guangzhou, China; Yuan, L., Guangdong Province Key Laboratory of Microbial Signals Disease Control, Integrative Microbiology Research Centre, South China Agricultural University, Guangzhou, China; Dai, G., Guangdong Province Key Laboratory of Microbial Signals Disease Control, Integrative Microbiology Research Centre, South China Agricultural University, Guangzhou, China; Chen, R.A., College of Veterinary Medicine, South China Agricultural University, Guangzhou, China, Zhaoqing DaHuaNong Biology Medicine Co., Ltd, Zhaoqing, China; Liu, D.X., Guangdong Province Key Laboratory of Microbial Signals Disease Control, Integrative Microbiology Research Centre, South China Agricultural University, Guangzhou, China; Fung, T.S., Guangdong Province Key Laboratory of Microbial Signals Disease Control, Integrative Microbiology Research Centre, South China Agricultural University, Guangzhou, China","Coronavirus (CoV) envelope (E) protein is a small structural protein critical for virion morphogenesis and release. The recently characterized E protein ion channel activity (EIC) has also been implicated in modulating viral pathogenesis. In this study, we used infectious bronchitis coronavirus (IBV) as a model to study EIC. Two recombinant IBVs (rIBVs) harboring EIC-inactivating mutations – rT16A and rA26F – were serially passaged, and several compensatory mutations were identified in the transmembrane domain (TMD). Two rIBVs harboring these putative EIC-reverting mutations – rT16A/A26V and rA26F/F14N – were recovered. Compared with the parental rIBV-p65 control, all four EIC mutants exhibited comparable levels of intracellular RNA synthesis, structural protein production, and virion assembly. Our results showed that the IBV EIC contributed to the induction of ER stress response, as up-regulation of ER stress-related genes was markedly reduced in cells infected with the EIC-defective mutants. EIC-defective mutants also formed smaller plaques, released significantly less infectious virions into the culture supernatant, and had lower levels of viral fitness in cell culture. Significantly, all these defective phenotypes were restored in cells infected with the putative EIC revertants. EIC mutations were also implicated in regulating IBV-induced apoptosis, induction of pro-inflammatory cytokines, and viral pathogenicity in vivo. Taken together, this study highlights the importance of CoV EIC in modulating virion release and various aspects of CoV – host interaction. © Copyright © 2020 Li, Yuan, Dai, Chen, Liu and Fung.",coronavirus; ER stress response; ion channel activity; pathogenesis; pro-inflammatory cytokine; viroporin,endoplasmic reticulum associated DNAJ protein 4; glucose regulated protein 78; glucose regulated protein 94; growth arrest and DNA damage inducible protein 153; homocysteine responsive endoplasmic reticulum resident ubiquitin like domain member 1; interleukin 6; interleukin 8; ion channel; M protein; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase; peptides and proteins; protein DnaJ; protein kinase RNA like endoplasmic reticulum kinase; protein p58; unclassified drug; virus envelope protein; X box binding protein 1; amino acid sequence; animal cell; apoptosis; Article; avian infectious bronchitis; Avian infectious bronchitis virus; competitive binding assay; controlled study; ELD50; embryo; endoplasmic reticulum stress; gene expression; gene mutation; genetic stability; ID50 (median infectious dose); lethal dose; mRNA expression level; nonhuman; phase contrast microscopy; protein expression; protein synthesis; real time reverse transcription polymerase chain reaction; RNA extraction; RNA synthesis; TCID50; upregulation; Vero cell line; viral plaque assay; virus assembly; virus cell interaction; virus culture; virus pathogenesis; virus recombinant; virus release; virus titration; Western blotting,"Bos, E.C., Luytjes, W., van der Meulen, H.V., Koerten, H.K., Spaan, W.J., The production of recombinant infectious DI-particles of a murine coronavirus in the absence of helper virus (1996) Virology, 218, pp. 52-60. , 8615041; Castaño-Rodriguez, C., Honrubia, J.M., Gutiérrez-Álvarez, J., DeDiego, M.L., Nieto-Torres, J.L., Jimenez-Guardeño, J.M., Role of severe acute respiratory syndrome coronavirus viroporins e, 3a, and 8a in replication and pathogenesis (2018) mBio, 9 (e2325-17). , 29789363; Chen, C.-C., Krüger, J., Sramala, I., Hsu, H.-J., Henklein, P., Chen, Y.M.A., ORF8a of SARS-CoV forms an ion channel: experiments and molecular dynamics simulations (2011) Biochim. 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Virol, 83, pp. 8744-8758. , 19553314; Yamada, Y., Liu, X.B., Fang, S.G., Tay, F.P.L., Liu, D.X., Acquisition of cell–cell fusion activity by amino acid substitutions in spike protein determines the infectivity of a coronavirus in cultured cells (2009) PLoS One, 4 (e6130). , 19572016; Yuan, Q., Liao, Y., Torres, J., Tam, J.P., Liu, D.X., Biochemical evidence for the presence of mixed membrane topologies of the severe acute respiratory syndrome coronavirus envelope protein expressed in mammalian cells (2006) FEBS Lett, 580, pp. 3192-3200. , 16684538; Zheng, J., Yamada, Y., Fung, T.S., Huang, M., Chia, R., Liu, D.X., Identification of N-linked glycosylation sites in the spike protein and their functional impact on the replication and infectivity of coronavirus infectious bronchitis virus in cell culture (2018) Virology, 513, pp. 65-74. , 29035787","Liu, D.X.; Guangdong Province Key Laboratory of Microbial Signals Disease Control, Integrative Microbiology Research Centre, South China Agricultural UniversityChina; email: dxliu0001@163.com",,Frontiers Media S.A.,1664302X,,,,English,Front. Microbiol.,Article,Final,Open Access,Scopus,2-s2.0-85079135665,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Mahase E.,57208387961;,China coronavirus: what do we know so far?,2020,BMJ (Clinical research ed.),368,,,m308,,,8,10.1136/bmj.m308,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078236524&doi=10.1136%2fbmj.m308&partnerID=40&md5=67c80574a1042201dcb5e6b4f68bafb2,BMJ,"Mahase, E., BMJ",[No abstract available],,,,,,NLM (Medline),17561833,,,31980434,English,BMJ,Article,Final,Open Access,Scopus,2-s2.0-85078236524,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Banerjee A., Baker M.L., Kulcsar K., Misra V., Plowright R., Mossman K.",56412355200;56753420600;55805281200;7201897411;15078101700;35243393500;,Novel Insights Into Immune Systems of Bats,2020,Frontiers in Immunology,11,,26,,,,2,10.3389/fimmu.2020.00026,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079160618&doi=10.3389%2ffimmu.2020.00026&partnerID=40&md5=7c5bdf10827cf548b9bb7788571e5ecd,"Department of Pathology and Molecular Medicine, Michael DeGroote Institute for Infectious Disease Research, McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada; Health and Biosecurity Business Unit, Australian Animal Health Laboratory, CSIRO, Geelong, VIC, Australia; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, United States; Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada; Department of Microbiology and Immunology, Montana State University, Bozeman, MT, United States","Banerjee, A., Department of Pathology and Molecular Medicine, Michael DeGroote Institute for Infectious Disease Research, McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada; Baker, M.L., Health and Biosecurity Business Unit, Australian Animal Health Laboratory, CSIRO, Geelong, VIC, Australia; Kulcsar, K., Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, United States; Misra, V., Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada; Plowright, R., Department of Microbiology and Immunology, Montana State University, Bozeman, MT, United States; Mossman, K., Department of Pathology and Molecular Medicine, Michael DeGroote Institute for Infectious Disease Research, McMaster Immunology Research Centre, McMaster University, Hamilton, ON, Canada","In recent years, viruses similar to those that cause serious disease in humans and other mammals have been detected in apparently healthy bats. These include filoviruses, paramyxoviruses, and coronaviruses that cause severe diseases such as Ebola virus disease, Marburg haemorrhagic fever and severe acute respiratory syndrome (SARS) in humans. The evolution of flight in bats seem to have selected for a unique set of antiviral immune responses that control virus propagation, while limiting self-damaging inflammatory responses. Here, we summarize our current understanding of antiviral immune responses in bats and discuss their ability to co-exist with emerging viruses that cause serious disease in other mammals. We highlight how this knowledge may help us to predict viral spillovers into new hosts and discuss future directions for the field. © Copyright © 2020 Banerjee, Baker, Kulcsar, Misra, Plowright and Mossman.",antiviral; bats (Chiroptera); emerging viruses; innate and adaptive immune response; interferon; virus,,"Field, H., Young, P., Yob, J.M., Mills, J., Hall, L., Mackenzie, J., The natural history of Hendra and Nipah viruses (2001) Microbes Infect, 3, pp. 307-314. , 11334748; Li, W., Shi, Z., Yu, M., Ren, W., Smith, C., Epstein, J.H., Bats are natural reservoirs of SARS-like coronaviruses (2005) Science, 310, pp. 676-679. , 16195424; (2004) Severe Acute Respiratory Syndrome, , https://www.cdc.gov/sars/about/fs-sars.html, Available online at:, (cited February.2.001 20, 2019; Guan, Y., Zheng, B.J., He, Y.Q., Liu, X.L., Zhuang, Z.X., Cheung, C.L., Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China (2003) Science, 302, pp. 276-278. , 12958366; Lau, S.K., Woo, P.C., Li, K.S., Huang, Y., Tsoi, H.W., Wong, B.H., Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats (2005) Proc Natl Acad Sci USA, 102, pp. 14040-14045. , 16169905; Forbes, K.M., Webala, P.W., Jaaskelainen, A.J., Abdurahman, S., Ogola, J., Masika, M.M., Bombali Virus in Mops condylurus Bat, Kenya (2019) Emerg Infect Dis, 25, pp. 955-957. , 31002301; Goldstein, T., Anthony, S.J., Gbakima, A., Bird, B.H., Bangura, J., Tremeau-Bravard, A., The discovery of Bombali virus adds further support for bats as hosts of ebolaviruses (2018) Nat Microbiol, 3, pp. 1084-1089; Towner, J.S., Pourrut, X., Albarino, C.G., Nkogue, C.N., Bird, B.H., Grard, G., Marburg virus infection detected in a common African bat (2007) PLoS ONE, 2, p. e764. , 17712412; Drexler, J.F., Corman, V.M., Muller, M.A., Maganga, G.D., Vallo, P., Binger, T., Bats host major mammalian paramyxoviruses (2012) Nat Commun, 3, p. 796. , 22531181; Hu, B., Zeng, L.P., Yang, X.L., Ge, X.Y., Zhang, W., Li, B., Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus (2017) PLoS Pathog, 13, p. e1006698. , 29190287; Ge, X.Y., Li, J.L., Yang, X.L., Chmura, A.A., Zhu, G., Epstein, J.H., Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor (2013) Nature, 503, pp. 535-538. , 24172901; Anthony, S.J., Gilardi, K., Menachery, V.D., Goldstein, T., Ssebide, B., Mbabazi, R., Further evidence for bats as the evolutionary source of middle east respiratory syndrome coronavirus (2017) MBio, 8, pp. e00373-e317. , 28377531; Memish, Z.A., Mishra, N., Olival, K.J., Fagbo, S.F., Kapoor, V., Epstein, J.H., Middle East respiratory syndrome coronavirus in bats, Saudi Arabia (2013) Emerg Infect Dis, 19, pp. 1819-1823. , 24206838; Ithete, N.L., Stoffberg, S., Corman, V.M., Cottontail, V.M., Richards, L.R., Schoeman, M.C., Close relative of human Middle East respiratory syndrome coronavirus in bat, South Africa (2013) Emerg Infect Dis, 19, pp. 1697-1699. , 24050621; Zhou, P., Tachedjian, M., Wynne, J.W., Boyd, V., Cui, J., Smith, I., Contraction of the type I IFN locus and unusual constitutive expression of IFN-alpha in bats (2016) Proc Natl Acad Sci USA, 113, pp. 2696-2701. , 26903655; Pavlovich, S.S., Lovett, S.P., Koroleva, G., Guito, J.C., Arnold, C.E., Nagle, E.R., The egyptian rousette genome reveals unexpected features of bat antiviral immunity (2018) Cell, 173, pp. 1098-1010. , 29706541; Ahn, M., Anderson, D.E., Zhang, Q., Tan, C.W., Lim, B.L., Luko, K., Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host (2019) Nat Microbiol, 4, pp. 789-799. , 30804542; Fenton, M.B., Simmons, N.B., (2015) Bats, a World of Science and Mystery, p. 303. , Chicago, IL, The University of Chicago Press, :, p; Lei, M., Dong, D., Phylogenomic analyses of bat subordinal relationships based on transcriptome data (2016) Sci Rep, 6, p. 27726. , 27291671; O'Leary, M.A., Bloch, J.I., Flynn, J.J., Gaudin, T.J., Giallombardo, A., Giannini, N.P., The placental mammal ancestor and the post-K-Pg radiation of placentals (2013) Science, 339, pp. 662-667. , 23393258; Simmons, N.B., Seymour, K.L., Habersetzer, J., Gunnell, G.F., Primitive early eocene bat from Wyoming and the evolution of flight and echolocation (2008) Nature, 451, pp. 818-821. , 18270539; Luis, A.D., Hayman, D.T., O'Shea, T.J., Cryan, P.M., Gilbert, A.T., Pulliam, J.R., A comparison of bats and rodents as reservoirs of zoonotic viruses: are bats special? 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Jebb, D., Foley, N.M., Whelan, C.V., Touzalin, F., Puechmaille, S.J., Teeling, E.C., Population level mitogenomics of long-lived bats reveals dynamic heteroplasmy and challenges the free radical theory of ageing (2018) Sci Rep, 8, p. 13634. , 30206380","Mossman, K.; Department of Pathology and Molecular Medicine, Michael DeGroote Institute for Infectious Disease Research, McMaster Immunology Research Centre, McMaster UniversityCanada; email: mossk@mcmaster.ca",,Frontiers Media S.A.,16643224,,,32117225,English,Front. Immunol.,Review,Final,Open Access,Scopus,2-s2.0-85079160618,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Battegay M., Kuehl R., Tschudin-Sutter S., Hirsch H.H., Widmer A.F., Neher R.A.",7004770044;35311036600;36549279500;7202406848;7005334898;6603836964;,2019-novel Coronavirus (2019-nCoV): estimating the case fatality rate - a word of caution,2020,Swiss medical weekly,150,,,w20203,,,6,10.4414/smw.2020.20203,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079082904&doi=10.4414%2fsmw.2020.20203&partnerID=40&md5=d8c5e1541d62c2b9167679f1bbb876fa,"Division of Infectious Diseases & Hospital Epidemiology, University Hospital Basel, Basel, Switzerland; Division of Infectious Diseases & Hospital Epidemiology, University Hospital Basel, Basel, Switzerland; Clinical Virology, Laboratory Medicine, University Hospital Basel, Switzerland; Transplantation and Clinical Virology, Department Biomedicine, University of Basel, Switzerland; Biozentrum, University of Basel, Switzerland","Battegay, M., Division of Infectious Diseases & Hospital Epidemiology, University Hospital Basel, Basel, Switzerland; Kuehl, R., Division of Infectious Diseases & Hospital Epidemiology, University Hospital Basel, Basel, Switzerland; Tschudin-Sutter, S., Division of Infectious Diseases & Hospital Epidemiology, University Hospital Basel, Basel, Switzerland; Hirsch, H.H., Division of Infectious Diseases & Hospital Epidemiology, University Hospital Basel, Basel, Switzerland; Clinical Virology, Laboratory Medicine, University Hospital Basel, Switzerland; Transplantation and Clinical Virology, Department Biomedicine, University of Basel, Switzerland; Widmer, A.F., Division of Infectious Diseases & Hospital Epidemiology, University Hospital Basel, Basel, Switzerland; Neher, R.A., Biozentrum, University of Basel, Switzerland",[No abstract available],,"COVID-19; Coronavirus infection; human; mortality; virus pneumonia; Coronavirus Infections; Humans; Mortality; Pneumonia, Viral",,,,NLM (Medline),14243997,,,32031234,English,Swiss Med Wkly,Editorial,Final,Open Access,Scopus,2-s2.0-85079082904,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Liu J., Wang F., Du L., Li J., Yu T., Jin Y., Yan Y., Zhou J., Gu J.",57197746059;57215014376;57200567662;57215009003;57212868920;24385495800;57212121053;54682580100;35302463200;,Comprehensive Genomic Characterization Analysis of lncRNAs in Cells With Porcine Delta Coronavirus Infection,2020,Frontiers in Microbiology,10,,3036,,,,,10.3389/fmicb.2019.03036,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079633265&doi=10.3389%2ffmicb.2019.03036&partnerID=40&md5=abad8c0d678c4561973f9621e3fa41fd,"MOE International Joint Collaborative Research Laboratory for Animal Health and Food Safety, Institute of Immunology, Nanjing Agricultural University, Nanjing, China; MOA Key Laboratory of Animal Virology, Department of Veterinary Medicine, Zhejiang University, Hangzhou, China","Liu, J., MOE International Joint Collaborative Research Laboratory for Animal Health and Food Safety, Institute of Immunology, Nanjing Agricultural University, Nanjing, China; Wang, F., MOE International Joint Collaborative Research Laboratory for Animal Health and Food Safety, Institute of Immunology, Nanjing Agricultural University, Nanjing, China; Du, L., MOE International Joint Collaborative Research Laboratory for Animal Health and Food Safety, Institute of Immunology, Nanjing Agricultural University, Nanjing, China; Li, J., MOE International Joint Collaborative Research Laboratory for Animal Health and Food Safety, Institute of Immunology, Nanjing Agricultural University, Nanjing, China; Yu, T., MOE International Joint Collaborative Research Laboratory for Animal Health and Food Safety, Institute of Immunology, Nanjing Agricultural University, Nanjing, China; Jin, Y., MOA Key Laboratory of Animal Virology, Department of Veterinary Medicine, Zhejiang University, Hangzhou, China; Yan, Y., MOA Key Laboratory of Animal Virology, Department of Veterinary Medicine, Zhejiang University, Hangzhou, China; Zhou, J., MOA Key Laboratory of Animal Virology, Department of Veterinary Medicine, Zhejiang University, Hangzhou, China; Gu, J., MOE International Joint Collaborative Research Laboratory for Animal Health and Food Safety, Institute of Immunology, Nanjing Agricultural University, Nanjing, China","Porcine delta coronavirus (PDCoV) is a novel emerging enterocytetropic virus causing diarrhea, vomiting, dehydration, and mortality in suckling piglets. Long non-coding RNAs (lncRNAs) are known to be important regulators during virus infection. Here, we describe a comprehensive transcriptome profile of lncRNA in PDCoV-infected swine testicular (ST) cells. In total, 1,308 annotated and 1,190 novel lncRNA candidate sequences were identified. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed that these lncRNAs might be involved in numerous biological processes. Clustering analysis of differentially expressed lncRNAs showed that 454 annotated and 376 novel lncRNAs were regulated after PDCoV infection. Furthermore, we constructed a lncRNA-protein-coding gene co-expression interaction network. The KEGG analysis of the co-expressed genes showed that these differentially expressed lncRNAs were enriched in pathways related to metabolism and TNF signaling. Our study provided comprehensive information about lncRNAs that would be a useful resource for studying the pathogenesis of and designing antiviral therapy for PDCoV infection. © Copyright © 2020 Liu, Wang, Du, Li, Yu, Jin, Yan, Zhou and Gu.",lncRNA; metabolic pathway; PDCoV infection; RNA-seq; TNF,CXCL2 chemokine; gamma interferon inducible protein 10; immunoglobulin enhancer binding protein; interleukin 6; long untranslated RNA; macrophage inflammatory protein 3alpha; mitogen activated protein kinase 3; RANTES; transcriptome; animal cell; Article; cell culture; clustering algorithm; Coronavirinae; Coronavirus infection; down regulation; exon; gene cluster; gene expression; gene ontology; genetic conservation; genome analysis; high throughput sequencing; IPEC-J2 cell line; microarray analysis; molecular genetics; mouse; nonhuman; Porcine deltacoronavirus; protein expression; real time polymerase chain reaction; RNA extraction; signal transduction; testicular cell line; upregulation; virus characterization; virus gene,"Ajayi, T., Dara, R., Misener, M., Pasma, T., Moser, L., Poljak, Z., Herd-level prevalence and incidence of porcine epidemic diarrhoea virus (PEDV) and porcine deltacoronavirus (PDCoV) in swine herds in Ontario, Canada (2018) Transbound. Emerg. Dis, 65, pp. 1197-1207. , 29607611; Betakova, T., Kostrabova, A., Lachova, V., Turianova, L., Cytokines induced during influenza virus infection (2017) Curr. Pharm. Des, 23, pp. 2616-2622. , 28302021; Carpenter, S., Aiello, D., Atianand, M.K., Ricci, E.P., Gandhi, P., Hall, L.L., A long noncoding RNA mediates both activation and repression of immune response genes (2013) Science, 341, pp. 789-792. , 23907535; Clark, B.S., Blackshaw, S., Long non-coding RNA-dependent transcriptional regulation in neuronal development and disease (2014) Front. Genet, 5 (164). , 24936207; Derrien, T., Johnson, R., Bussotti, G., Tanzer, A., Djebali, S., Tilgner, H., The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression (2012) Genom. Res, 22, pp. 1775-1789. , 22955988; Dong, N., Fang, L., Yang, H., Liu, H., Du, T., Fang, P., Isolation, genomic characterization, and pathogenicity of a Chinese porcine deltacoronavirus strain CHN-HN-2014 (2016) Vet. Microbiol, 196, pp. 98-106. , 27939164; Fang, P., Fang, L., Hong, Y., Liu, X., Dong, N., Ma, P., Discovery of a novel accessory protein NS7a encoded by porcine deltacoronavirus (2017) J. Gen. Virol, 98, pp. 173-178. , 27995863; Fang, P., Fang, L., Ren, J., Hong, Y., Liu, X., Zhao, Y., Porcine deltacoronavirus accessory protein NS6 antagonizes interferon beta production by interfering with the binding of RIG-I/MDA5 to double-stranded RNA (2018) J. Virol, 92 (e00712-18). , 29769346; Gomez, J.A., Wapinski, O.L., Yang, Y.W., Bureau, J.F., Gopinath, S., Monack, D.M., The NeST long ncRNA controls microbial susceptibility and epigenetic activation of the interferon-gamma locus (2013) Cell, 152, pp. 743-754. , 23415224; Heward, J.A., Lindsay, M.A., Long non-coding RNAs in the regulation of the immune response (2014) Trends Immunol, 35, pp. 408-419. , 25113636; Huarte, M., Guttman, M., Feldser, D., Garber, M., Koziol, M.J., Kenzelmann-Broz, D., A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response (2010) Cell, 142, pp. 409-419. , 20673990; Imamura, K., Imamachi, N., Akizuki, G., Kumakura, M., Kawaguchi, A., Nagata, K., Long noncoding RNA NEAT1-dependent SFPQ relocation from promoter region to paraspeckle mediates IL8 expression upon immune stimuli (2014) Mol. Cell, 53, pp. 393-406. , 24507715; Kapranov, P., Cheng, J., Dike, S., Nix, D.A., Duttagupta, R., Willingham, A.T., RNA maps reveal new RNA classes and a possible function for pervasive transcription (2007) Science, 316, pp. 1484-1488. , 17510325; Lee, S., Lee, C., Complete genome characterization of korean porcine deltacoronavirus strain KOR/KNU14-04/2014 (2014) Genom. Announc, 2 (e01191-14). , 25428966; Li, Z., Chao, T.C., Chang, K.Y., Lin, N., Patil, V.S., Shimizu, C., The long noncoding RNA THRIL regulates TNFalpha expression through its interaction with hnRNPL (2014) Proc. Natl. Acad. Sci. U.S.A, 111, pp. 1002-1007. , 24371310; Lorsirigool, A., Saeng-Chuto, K., Madapong, A., Temeeyasen, G., Tripipat, T., Kaewprommal, P., The genetic diversity and complete genome analysis of two novel porcine Deltacoronavirus isolates in Thailand in 2015 (2017) Virus Genes, 53, pp. 240-248. , 28005234; Luo, S., Lu, J.Y., Liu, L., Yin, Y., Chen, C., Han, X., Divergent lncRNAs regulate gene expression and lineage differentiation in pluripotent cells (2016) Cell Stem Cell, 18, pp. 637-652. , 26996597; Ma, Y., Zhang, Y., Liang, X., Lou, F., Oglesbee, M., Krakowka, S., Origin, evolution, and virulence of porcine deltacoronaviruses in the United States (2015) mBio, 6 (e00064). , 25759498; Mao, X., Cai, T., Olyarchuk, J.G., Wei, L., Automated genome annotation and pathway identification using the KEGG Orthology (KO) as a controlled vocabulary (2005) Bioinformatics, 21, pp. 3787-3793. , 15817693; Masood, K.I., Jamil, B., Rahim, M., Islam, M., Farhan, M., Hasan, Z., Role of TNF alpha, IL-6 and CXCL10 in Dengue disease severity (2018) Iran J. Microbiol, 10, pp. 202-207. , 30112159; Mattick, J.S., Rinn, J.L., Discovery and annotation of long noncoding RNAs (2015) Nat. Struct. Mol. Biol, 22, pp. 5-7. , 25565026; Mercer, T.R., Dinger, M.E., Mattick, J.S., Long non-coding RNAs: insights into functions (2009) Nat. Rev. Genet, 10, pp. 155-159. , 19188922; Mercer, T.R., Dinger, M.E., Sunkin, S.M., Mehler, M.F., Mattick, J.S., Specific expression of long noncoding RNAs in the mouse brain (2008) Proc. Natl. Acad. Sci. U.S.A, 105, pp. 716-721. , 18184812; Ouyang, J., Zhu, X., Chen, Y., Wei, H., Chen, Q., Chi, X., NRAV, a long noncoding RNA, modulates antiviral responses through suppression of interferon-stimulated gene transcription (2014) Cell Host Microb, 16, pp. 616-626. , 25525793; Ponting, C.P., Oliver, P.L., Reik, W., Evolution and functions of long noncoding RNAs (2009) Cell, 136, pp. 629-641. , 19239885; Qureshi, I.A., Mattick, J.S., Mehler, M.F., Long non-coding RNAs in nervous system function and disease (2010) Brain Res, 1338, pp. 20-35. , 20380817; Saeng-Chuto, K., Jermsutjarit, P., Stott, C.J., Vui, D.T., Tantituvanont, A., Nilubol, D., Retrospective study, full-length genome characterization and evaluation of viral infectivity and pathogenicity of chimeric porcine deltacoronavirus detected in Vietnam (2019) Transbound. Emerg. Dis, , [Epub ahead of print], 31469947; Shannon, P., Markiel, A., Ozier, O., Baliga, N.S., Wang, J.T., Ramage, D., Cytoscape: a software environment for integrated models of biomolecular interaction networks (2003) Genom. Res, 13, pp. 2498-2504. , 14597658; Trapnell, C., Williams, B.A., Pertea, G., Mortazavi, A., Kwan, G., van Baren, M.J., Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation (2010) Nat. Biotechnol, 28, pp. 511-515. , 20436464; Tsai, M.C., Spitale, R.C., Chang, H.Y., Long intergenic noncoding RNAs: new links in cancer progression (2011) Cancer Res, 71, pp. 3-7. , 21199792; Wang, P., Xu, J., Wang, Y., Cao, X., An interferon-independent lncRNA promotes viral replication by modulating cellular metabolism (2017) Science, 358, pp. 1051-1055. , 29074580; Woo, P.C., Lau, S.K., Lam, C.S., Lau, C.C., Tsang, A.K., Lau, J.H., Discovery of seven novel Mammalian and avian Coronaviruses in the genus Deltacoronavirus supports bat Coronaviruses as the gene source of Alphacoronavirus and Betacoronavirus and avian Coronaviruses as the gene source of Gammacoronavirus and Deltacoronavirus (2012) J. Virol, 86, pp. 3995-4008. , 22278237; Wu, J.L., Mai, K.J., Li, D., Wu, R.T., Wu, Z.X., Tang, X.Y., Expression profile analysis of 5-day-old neonatal piglets infected with porcine Deltacoronavirus (2019) BMC Vet. Res, 15 (117). , 30992015; Zhang, Q., Chen, C.Y., Yedavalli, V.S., Jeang, K.T., NEAT1 long noncoding RNA and paraspeckle bodies modulate HIV-1 posttranscriptional expression (2013) mBio, 4 (e596-12). , 23362321; Zhu, X., Fang, L., Wang, D., Yang, Y., Chen, J., Ye, X., Porcine Deltacoronavirus nsp5 inhibits interferon-beta production through the cleavage of NEMO (2017) Virology, 502, pp. 33-38. , a, 27984784; Zhu, X., Wang, D., Zhou, J., Pan, T., Chen, J., Yang, Y., Porcine Deltacoronavirus nsp5 antagonizes type I interferon signaling by cleaving STAT2 (2017) J. Virol, 91 (e00003-17). , b, 28250121","Gu, J.; MOE International Joint Collaborative Research Laboratory for Animal Health and Food Safety, Institute of Immunology, Nanjing Agricultural UniversityChina; email: GJY@njau.edu.cn",,Frontiers Media S.A.,1664302X,,,,English,Front. Microbiol.,Article,Final,Open Access,Scopus,2-s2.0-85079633265,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Mahase E.,57208387961;,"China coronavirus: mild but infectious cases may make it hard to control outbreak, report warns",2020,BMJ (Clinical research ed.),368,,,m325,,,1,10.1136/bmj.m325,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078688031&doi=10.1136%2fbmj.m325&partnerID=40&md5=04b0d606487a4b1080225190171db1e8,BMJ,"Mahase, E., BMJ",[No abstract available],,,,,,NLM (Medline),17561833,,,31992570,English,BMJ,Article,Final,Open Access,Scopus,2-s2.0-85078688031,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Moberly T.,55661023200;,Chinese premier rallies medics in coronavirus fight,2020,BMJ (Clinical research ed.),368,,,m343,,,,10.1136/bmj.m343,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078687959&doi=10.1136%2fbmj.m343&partnerID=40&md5=69959f8cc68b66a9e7d1cfa3a2a30b2a,BMJ,"Moberly, T., BMJ",[No abstract available],,,,,,NLM (Medline),17561833,,,31992554,English,BMJ,Article,Final,Open Access,Scopus,2-s2.0-85078687959,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Akhrymuk I., Lin S.-C., Sun M., Patnaik A., Lehman C., Altamura L., Minogue T., Lepene B., van Hoek M.L., Kehn-Hall K.",55224005500;57192909217;57214991726;57213191835;57201980678;8226372000;6506772991;6508323103;6507221859;35553615900;,Magnetic Nanotrap Particles Preserve the Stability of Venezuelan Equine Encephalitis Virus in Blood for Laboratory Detection,2020,Frontiers in Veterinary Science,6,,509,,,,,10.3389/fvets.2019.00509,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079687195&doi=10.3389%2ffvets.2019.00509&partnerID=40&md5=34d59c8073f55d0cde1e9ed7eb99ec87,"National Center for Biodefense and Infectious Diseases, School of Systems Biology, George Mason University, Manassas, VA, United States; United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, United States; Ceres Nanosciences, Inc, Manassas, VA, United States","Akhrymuk, I., National Center for Biodefense and Infectious Diseases, School of Systems Biology, George Mason University, Manassas, VA, United States; Lin, S.-C., National Center for Biodefense and Infectious Diseases, School of Systems Biology, George Mason University, Manassas, VA, United States; Sun, M., United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, United States; Patnaik, A., Ceres Nanosciences, Inc, Manassas, VA, United States; Lehman, C., National Center for Biodefense and Infectious Diseases, School of Systems Biology, George Mason University, Manassas, VA, United States; Altamura, L., United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, United States; Minogue, T., United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD, United States; Lepene, B., Ceres Nanosciences, Inc, Manassas, VA, United States; van Hoek, M.L., National Center for Biodefense and Infectious Diseases, School of Systems Biology, George Mason University, Manassas, VA, United States; Kehn-Hall, K., National Center for Biodefense and Infectious Diseases, School of Systems Biology, George Mason University, Manassas, VA, United States","Most of the modern techniques used for identification of viral-induced disease are based on identification of viral antigens and/or nucleic acids in patient's blood. Diagnosis in the field or in remote locations can be challenging and alternatively samples are shipped to diagnostic labs for testing. Shipments must occur under controlled temperature conditions to prevent loss of sample integrity. We have tested the ability of magnetic Nanotrap® (NT) particles to improve stability and detection of Venezuelan equine encephalitis virus (VEEV), viral capsid protein, and viral genomic RNA in whole human blood at elevated temperature and prolonged storage conditions. NT particles have previously been shown to capture and enrich multiple pathogens including respiratory syncytial virus, influenza virus, coronavirus, and Rift Valley fever virus. Our study indicates that samples incubated with NT particles had detectable levels of infectious VEEV in blood equal to or greater than samples without NT treatment across all temperatures. Viral RNA detection was increased in the presence of NT particles at later time points (72 h) and higher temperature (40°C) conditions. Likewise, detection of VEEV capsid protein was enhanced in the presence of NT particles up to 72 h at 40°C. Finally, we intranasally infected C3H mice with TC-83, the live attenuated vaccine strain of VEEV, and demonstrated that NT particles could substantially increase the detection of VEEV capsid in infected blood incubated up to 72 h at 40°C. Samples without NT particles had undetectable capsid protein levels. Taken together, our data demonstrate the ability of NT particles to preserve and enable detection of VEEV in human and mouse blood samples over time and at elevated temperatures. © Copyright © 2020 Akhrymuk, Lin, Sun, Patnaik, Lehman, Altamura, Minogue, Lepene, van Hoek and Kehn-Hall.",alphavirus; diagnostics; nanoparticles; nanotrap particles; surveillance; Venezuelan equine encephalitis virus,capsid protein; genomic RNA; live vaccine; magnetic nanoparticle; animal experiment; Article; blood sampling; C3H mouse; Coronavirinae; high temperature; Human respiratory syncytial virus; incubation temperature; Influenza virus; laboratory test; mouse; nonhuman; Rift Valley fever virus; storage temperature; Venezuelan equine encephalitis virus; virus capsid; virus pathogenesis; virus strain,"Ryan, J.R., (2016) Biosecurity and Bioterrorism: Containing and Preventing Biological Threats, , Amsterdam, Elsevier/BH, Butterworth-Heinemann is an imprint of Elsevier; Beck, C.E., Wyckoff, R.W., Venezuelan equine encephalomyelitis (1938) Science, 88, p. 530. , 17840536; Zehmer, R.B., Dean, P.B., Sudia, W.D., Calisher, C.H., Sather, G.E., Parker, R.L., Venezuelan equine encephalitis epidemic in Texas, 1971 (1974) Health Serv Rep, 89, pp. 278-282. , 4151413; Knipe, D.M., Howley, P.M., (2013) Fields Virology, , Philadelphia, PA, Wolters Kluwer/Liincott Williams & Wilkins Health; Zacks, M.A., Paessler, S., Encephalitic alphaviruses (2010) Vet Microbiol, 140, pp. 281-286. , 19775836; Sharma, A., Knollmann-Ritschel, B., Current understanding of the molecular basis of venezuelan equine encephalitis virus pathogenesis and vaccine development (2019) Viruses, 11, p. 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Longo, C., Patanarut, A., George, T., Bishop, B., Zhou, W., Fredolini, C., Core-shell hydrogel particles harvest, concentrate and preserve labile low abundance biomarkers (2009) PLoS ONE, 4, p. e4763. , 19274087; Longo, C., Gambara, G., Espina, V., Luchini, A., Bishop, B., Patanarut, A.S., A novel biomarker harvesting nanotechnology identifies Bak as a candidate melanoma biomarker in serum (2011) Exp Dermatol, 20, pp. 29-34. , 21158936; Barclay, R.A., Schwab, A., DeMarino, C., Akpamagbo, Y., Lepene, B., Kassaye, S., Exosomes from uninfected cells activate transcription of latent HIV-1 (2017) J Biol Chem, 292, p. 14764","Kehn-Hall, K.; National Center for Biodefense and Infectious Diseases, School of Systems Biology, George Mason UniversityUnited States; email: kkehnhal@gmu.edu",,Frontiers Media S.A.,22971769,,,,English,Front. Vet. Sci.,Article,Final,Open Access,Scopus,2-s2.0-85079687195,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Parry J.,24605791400;,"China coronavirus: partial border closures into Hong Kong are not enough, say doctors",2020,BMJ (Clinical research ed.),368,,,m349,,,,10.1136/bmj.m349,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078689532&doi=10.1136%2fbmj.m349&partnerID=40&md5=3b36790c2a6823f2670f944c97b80323,"Hamilton, Canada","Parry, J., Hamilton, Canada",[No abstract available],,,,,,NLM (Medline),17561833,,,31996345,English,BMJ,Article,Final,Open Access,Scopus,2-s2.0-85078689532,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Cyranoski D.,57208765775;,This scientist hopes to test coronavirus drugs on animals in locked-down Wuhan,2020,Nature,577,7792,,607,,,3,10.1038/d41586-020-00190-6,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078672986&doi=10.1038%2fd41586-020-00190-6&partnerID=40&md5=3c18917fb19b6c709f53bb5d8a981fd8,,"Cyranoski, D.","Structural biologist Rolf Hilgenfeld has been working on coronavirus treatments since the SARS outbreak. [Figure not available: see fulltext.]. © 2020, Nature.",Diseases; Infection; Virology,"antivirus agent; angiotensin converting enzyme 2; antivirus agent; COVID-19; dipeptidyl carboxypeptidase; China; Coronavirinae; Coronavirus infection; drug activity; drug design; drug screening; Enterovirus A71; human; Human rhinovirus; Middle East respiratory syndrome; mouse model; Note; preclinical study; priority journal; safety; severe acute respiratory syndrome; animal; clinical trial (topic); Coronavirus infection; disease model; drug effect; genetics; interview; metabolism; Middle East respiratory syndrome coronavirus; mouse; patient selection; preclinical study; SARS coronavirus; severe acute respiratory syndrome; time factor; veterinary medicine; virology; virus pneumonia; Animalia; Coronavirus; Animals; Antiviral Agents; China; Clinical Trials as Topic; Coronavirus; Coronavirus Infections; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Mice; Middle East Respiratory Syndrome Coronavirus; Patient Selection; Peptidyl-Dipeptidase A; Pneumonia, Viral; SARS Virus; Severe Acute Respiratory Syndrome; Time Factors",,"Cyranoski, D.",,Nature Research,280836,,NATUA,31992886,English,Nature,Note,Final,Open Access,Scopus,2-s2.0-85078672986,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Koenig K.L., Beÿ C.K., McDonald E.C.",7102611021;57215840101;57215840655;,2019-nCoV: The Identify-Isolate-Inform (3I) Tool Applied to a Novel Emerging Coronavirus,2020,The western journal of emergency medicine,21,2,,184,190,,,10.5811/westjem.2020.1.46760,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082070787&doi=10.5811%2fwestjem.2020.1.46760&partnerID=40&md5=2ee53d21bd3e7ae4ec75dc2a6b0b8a7d,"County of San Diego, Health & Human Services Agency, Emergency Medical Services, San Diego, CA, Mexico; University of California Irvine, Department of Emergency Medicine, Orange, CA, United States; University of California San Diego, La JollaCA; County of San Diego, Health & Human Services Agency, Public Health Services, San Diego, CA, Mexico","Koenig, K.L., County of San Diego, Health & Human Services Agency, Emergency Medical Services, San Diego, CA, Mexico, University of California Irvine, Department of Emergency Medicine, Orange, CA, United States; Beÿ, C.K., University of California San Diego, La JollaCA; McDonald, E.C., County of San Diego, Health & Human Services Agency, Public Health Services, San Diego, CA, Mexico","2019 Novel Coronavirus (2019-nCoV) is an emerging infectious disease closely related to MERS-CoV and SARS-CoV that was first reported in Wuhan City, Hubei Province, China in December 2019. As of January 2020, cases of 2019-nCoV are continuing to be reported in other Eastern Asian countries as well as in the United States, Europe, Australia, and numerous other countries. An unusually high volume of domestic and international travel corresponding to the beginning of the 2020 Chinese New Year complicated initial identification and containment of infected persons. Due to the rapidly rising number of cases and reported deaths, all countries should be considered at risk of imported 2019-nCoV. Therefore, it is essential for prehospital, clinic, and emergency department personnel to be able to rapidly assess 2019-nCoV risk and take immediate actions if indicated. The Identify-Isolate-Inform (3I) Tool, originally conceived for the initial detection and management of Ebola virus and later adjusted for other infectious agents, can be adapted for any emerging infectious disease. This paper reports a modification of the 3I Tool for use in the initial detection and management of patients under investigation for 2019-nCoV. After initial assessment for symptoms and epidemiological risk factors, including travel to affected areas and exposure to confirmed 2019-nCoV patients within 14 days, patients are classified in a risk-stratified system. Upon confirmation of a suspected 2019-nCoV case, affected persons must immediately be placed in airborne infection isolation and the appropriate public health agencies notified. This modified 3I Tool will assist emergency and primary care clinicians, as well as out-of-hospital providers, in effectively managing persons with suspected or confirmed 2019-nCoV.",,"COVID-19; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; China; communicable disease; Coronavirus infection; decision support system; differential diagnosis; emergency health service; Europe; hospital emergency service; human; isolation and purification; risk factor; travel; virus pneumonia; Betacoronavirus; China; Communicable Diseases, Emerging; Coronavirus Infections; Decision Support Techniques; Diagnosis, Differential; Emergency Medical Services; Emergency Service, Hospital; Europe; Humans; Pneumonia, Viral; Risk Factors; Travel",,,,NLM (Medline),19369018,,,32191174,English,West J Emerg Med,Article,Final,Open Access,Scopus,2-s2.0-85082070787,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Mahase E.,57208387961;,China coronavirus: WHO declares international emergency as death toll exceeds 200,2020,BMJ (Clinical research ed.),368,,,m408,,,7,10.1136/bmj.m408,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078833627&doi=10.1136%2fbmj.m408&partnerID=40&md5=3e7c1b8267cf4ff7c1719902f3870fa8,BMJ,"Mahase, E., BMJ",[No abstract available],,,,,,NLM (Medline),17561833,,,32005727,English,BMJ,Article,Final,Open Access,Scopus,2-s2.0-85078833627,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Cohen J.,57203682506;,New coronavirus threat galvanizes scientists,2020,Science,367,6477,,492,493,,4,10.1126/science.367.6477.492,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078709834&doi=10.1126%2fscience.367.6477.492&partnerID=40&md5=82410e8f61977089cd09123e2db35edb,,"Cohen, J.",[No abstract available],,epidemic; global perspective; research work; science and technology; virus; 2019 novel coronavirus; China; Coronavirinae; disease transmission; epidemic; human; infection rate; life threat; population risk; priority journal; risk factor; Short Survey; China; Hubei; Wuhan; Coronavirus,,,,American Association for the Advancement of Science,368075,,SCIEA,32001631,English,Sci.,Short Survey,Final,Open Access,Scopus,2-s2.0-85078709834,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Grunewald M.E., Shaban M.G., MacKin S.R., Fehr A.R., Perlman S.",57193548278;57214076628;57214098963;36061058900;7102708317;,"Murine coronavirus infection activates the aryl hydrocarbon receptor in an indoleamine 2,3-dioxygenase-independent manner, contributing to cytokine modulation and proviral TCDD-inducible-PARP expression",2020,Journal of Virology,94,3, e01743-19,,,,1,10.1128/JVI.01743-19,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078214888&doi=10.1128%2fJVI.01743-19&partnerID=40&md5=bac14593b8869caeaa8f11833cee2101,"Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, United States; Department of Molecular Biosciences, University of Kansas, Lawrence, KS, United States","Grunewald, M.E., Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, United States; Shaban, M.G., Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, United States; MacKin, S.R., Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, United States; Fehr, A.R., Department of Molecular Biosciences, University of Kansas, Lawrence, KS, United States; Perlman, S., Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, United States","The aryl hydrocarbon receptor (AhR) is a cytoplasmic receptor/transcription factor that modulates several cellular and immunological processes following activation by pathogen-associated stimuli, though its role during virus infection is largely unknown. Here, we show that AhR is activated in cells infected with mouse hepatitis virus (MHV), a coronavirus (CoV), and contributes to the upregulation of downstream effector TCDD-inducible poly(ADP-ribose) polymerase (TiPARP) during infection. Knockdown of TiPARP reduced viral replication and increased interferon expression, suggesting that TiPARP functions in a proviral manner during MHV infection. We also show that MHV replication induced the expression of other genes known to be downstream of AhR in macrophages and dendritic cells and in livers of infected mice. Further, we found that chemically inhibiting or activating AhR reciprocally modulated the expression levels of cytokines induced by infection, specifically, interleukin 1β (IL-1β), IL-10, and tumor necrosis factor alpha (TNF-α), consistent with a role for AhR activation in the host response to MHV infection. Furthermore, while indoleamine 2,3-dioxygenase (IDO1) drives AhR activation in other settings, MHV infection induced equal expression of downstream genes in wild-type (WT) and IDO1-/- macrophages, suggesting an alternative pathway of AhR activation. In summary, we show that coronaviruses elicit AhR activation by an IDO1-independent pathway, contributing to upregulation of downstream effectors, including the proviral factor TiPARP, and to modulation of cytokine gene expression, and we identify a previously unappreciated role for AhR signaling in CoV pathogenesis. IMPORTANCE Coronaviruses are a family of positive-sense RNA viruses with human and agricultural significance. Characterizing the mechanisms by which coronavirus infection dictates pathogenesis or counters the host immune response would provide targets for the development of therapeutics. Here, we show that the aryl hydrocarbon receptor (AhR) is activated in cells infected with a prototypic coronavirus, mouse hepatitis virus (MHV), resulting in the expression of several effector genes. AhR is important for modulation of the host immune response to MHV and plays a role in the expression of TiPARP, which we show is required for maximal viral replication. Taken together, our findings highlight a previously unidentified role for AhR in regulating coronavirus replication and the immune response to the virus. Copyright © 2020 American Society for Microbiology. All Rights Reserved.",AhR; Coronavirus; IDO1; Mouse hepatitis virus; TiPARP,"2,3,7,8 tetrachlorodibenzo para dioxin; aromatic hydrocarbon receptor; cytokine; indoleamine 2,3 dioxygenase; interferon; interleukin 10; interleukin 1beta; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase; tumor necrosis factor; animal tissue; Article; cell viability assay; controlled study; Coronavirus infection; cytokine gene; dendritic cell; gene expression; gene knockdown; human; human cell; immune response; liver; macrophage; Murine coronavirus; Murine hepatitis virus; nonhuman; pathogenesis; priority journal; protein expression; protein function; reverse transcription polymerase chain reaction; signal transduction; upregulation; virus cell interaction; virus replication","Fehr, A.R., Perlman, S., Coronaviruses: An overview of their replication and pathogenesis (2015) Methods Mol Biol, 1282, pp. 1-23. , https://doi.org/10.1007/978-1-4939-2438-7_1; Bergmann, C.C., Lane, T.E., Stohlman, S.A., Coronavirus infection of the central nervous system: Host-virus stand-off (2006) Nat Rev Microbiol, 4, pp. 121-132. , https://doi.org/10.1038/nrmicro1343; 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Phelan, D., Winter, G.M., Rogers, W.J., Lam, J.C., Denison, M.S., Activation of the Ah receptor signal transduction pathway by bilirubin and biliverdin (1998) Arch Biochem Biophys, 357, pp. 155-163. , https://doi.org/10.1006/abbi.1998.0814; Metz, R., Rust, S., Duhadaway, J.B., Mautino, M.R., Munn, D.H., Vahanian, N.N., Link, C.J., Prendergast, G.C., IDO inhibits a tryptophan sufficiency signal that stimulates mTOR: A novel IDO effector pathway targeted by D-1- methyl-tryptophan (2012) Oncoimmunology, 1, pp. 1460-1468. , https://doi.org/10.4161/onci.21716; Orabona, C., Grohmann, U., Indoleamine 2,3-dioxygenase and regulatory function: Tryptophan starvation and beyond (2011) Methods Mol Biol, 677, pp. 269-280. , https://doi.org/10.1007/978-1-60761-869-0_19; Vogel, C.F., Sciullo, E., Matsumura, F., Involvement of RelB in aryl hydrocarbon receptor-mediated induction of chemokines (2007) Biochem Biophys Res Commun, 363, pp. 722-726. , https://doi.org/10.1016/j.bbrc.2007.09.032; Yount, B., Denison, M.R., Weiss, S.R., Baric, R.S., Systematic assembly of a full-length infectious cDNA of mouse hepatitis virus strain A59 (2002) J Virol, 76, pp. 11065-11078. , https://doi.org/10.1128/jvi.76.21.11065-11078.2002","Perlman, S.; Department of Microbiology and Immunology, University of IowaUnited States; email: stanley-perlman@uiowa.edu",,American Society for Microbiology,0022538X,,JOVIA,31694960,English,J. Virol.,Article,Final,Open Access,Scopus,2-s2.0-85078214888,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Bernard Stoecklin S., Rolland P., Silue Y., Mailles A., Campese C., Simondon A., Mechain M., Meurice L., Nguyen M., Bassi C., Yamani E., Behillil S., Ismael S., Nguyen D., Malvy D., Lescure F.X., Georges S., Lazarus C., Tabaï A., Stempfelet M., Enouf V., Coignard B., Levy-Bruhl D., Investigation Team",54997917000;7103185638;57215006194;8595630400;6602334555;57215007142;55849001000;56698383300;57215011510;57192191835;57214994149;35331786800;57203266516;57215007917;16138420100;7003588461;8259291300;57214999126;57215005875;35743899100;7801666642;16023753500;16301186700;37008771200;,"First cases of coronavirus disease 2019 (COVID-19) in France: surveillance, investigations and control measures, January 2020",2020,Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin,25,6,,,,,1,10.2807/1560-7917.ES.2020.25.6.2000094,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079664163&doi=10.2807%2f1560-7917.ES.2020.25.6.2000094&partnerID=40&md5=ad654efe4c4caef08a7a73316435fc51,"Santé publique France, Direction des maladies infectieuses, France; Santé publique France, Direction des régions, France; Santé publique France, Direction des régions, Paris, France; Agence Régionale de Santé Ile-de-France, Paris, France; Agence Régionale de Santé Nouvelle-Aquitaine, Bordeaux, France; Santé publique France, Direction des régions, Cellule Régionale Nouvelle-Aquitaine, Bordeaux, France; Centre National de Référence des virus des infections respiratoires, Institut Pasteur, Paris, France; AP-HP, Hôpital Bichat, Service des maladies infectieuses et tropicales, Paris, France; Centre Hospitalier Universitaire de Bordeaux, Service des maladies infectieuses et tropicales, Bordeaux GeoSentinel Site, Bordeaux, France; Université de Bordeaux, Bordeaux, France; Université de Paris, IAME, INSERM, Paris, France; Direction Générale de la Santé, Ministère des solidarités et de la santé, Centre opérationnel de réception et de régulation des urgences sanitaires et sociales, Paris, France; Santé publique France, Direction alerte et crise, France; The members of the investigation team are listed at the end of the article","Bernard Stoecklin, S., Santé publique France, Direction des maladies infectieuses, France; Rolland, P., Santé publique France, Direction des régions, France; Silue, Y., Santé publique France, Direction des régions, Paris, France; Mailles, A., Santé publique France, Direction des maladies infectieuses, France; Campese, C., Santé publique France, Direction des maladies infectieuses, France; Simondon, A., Agence Régionale de Santé Ile-de-France, Paris, France; Mechain, M., Agence Régionale de Santé Nouvelle-Aquitaine, Bordeaux, France; Meurice, L., Santé publique France, Direction des régions, Cellule Régionale Nouvelle-Aquitaine, Bordeaux, France; Nguyen, M., Agence Régionale de Santé Nouvelle-Aquitaine, Bordeaux, France; Bassi, C., Santé publique France, Direction des régions, Paris, France; Yamani, E., Agence Régionale de Santé Ile-de-France, Paris, France; Behillil, S., Centre National de Référence des virus des infections respiratoires, Institut Pasteur, Paris, France; Ismael, S., AP-HP, Hôpital Bichat, Service des maladies infectieuses et tropicales, Paris, France; Nguyen, D., Centre Hospitalier Universitaire de Bordeaux, Service des maladies infectieuses et tropicales, Bordeaux GeoSentinel Site, Bordeaux, France; Malvy, D., Centre Hospitalier Universitaire de Bordeaux, Service des maladies infectieuses et tropicales, Bordeaux GeoSentinel Site, Bordeaux, France, Université de Bordeaux, Bordeaux, France; Lescure, F.X., AP-HP, Hôpital Bichat, Service des maladies infectieuses et tropicales, Paris, France, Université de Paris, IAME, INSERM, Paris, France; Georges, S., Santé publique France, Direction des maladies infectieuses, France; Lazarus, C., Direction Générale de la Santé, Ministère des solidarités et de la santé, Centre opérationnel de réception et de régulation des urgences sanitaires et sociales, Paris, France; Tabaï, A., Santé publique France, Direction alerte et crise, France; Stempfelet, M., Santé publique France, Direction alerte et crise, France; Enouf, V., Centre National de Référence des virus des infections respiratoires, Institut Pasteur, Paris, France; Coignard, B., Santé publique France, Direction des maladies infectieuses, France; Levy-Bruhl, D., Santé publique France, Direction des maladies infectieuses, France; Investigation Team, The members of the investigation team are listed at the end of the article","A novel coronavirus (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2) causing a cluster of respiratory infections (coronavirus disease 2019, COVID-19) in Wuhan, China, was identified on 7 January 2020. The epidemic quickly disseminated from Wuhan and as at 12 February 2020, 45,179 cases have been confirmed in 25 countries, including 1,116 deaths. Strengthened surveillance was implemented in France on 10 January 2020 in order to identify imported cases early and prevent secondary transmission. Three categories of risk exposure and follow-up procedure were defined for contacts. Three cases of COVID-19 were confirmed on 24 January, the first cases in Europe. Contact tracing was immediately initiated. Five contacts were evaluated as at low risk of exposure and 18 at moderate/high risk. As at 12 February 2020, two cases have been discharged and the third one remains symptomatic with a persistent cough, and no secondary transmission has been identified. Effective collaboration between all parties involved in the surveillance and response to emerging threats is required to detect imported cases early and to implement adequate control measures.","contact tracing; containment; coronavirus; COVID-19, SARS-CoV-2, 2019-nCov; France; Surveillance","COVID-19; severe acute respiratory syndrome coronavirus 2; adult; Betacoronavirus; case report; China; contact examination; Coronavirus infection; France; health survey; human; infection control; isolation and purification; male; middle aged; risk assessment; travel; virus pneumonia; Adult; Betacoronavirus; China; Contact Tracing; Coronavirus Infections; France; Humans; Infection Control; Male; Middle Aged; Pneumonia, Viral; Population Surveillance; Risk Assessment; Travel",,,,NLM (Medline),15607917,,,32070465,English,Euro Surveill.,Article,Final,Open Access,Scopus,2-s2.0-85079664163,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Okada P., Buathong R., Phuygun S., Thanadachakul T., Parnmen S., Wongboot W., Waicharoen S., Wacharapluesadee S., Uttayamakul S., Vachiraphan A., Chittaganpitch M., Mekha N., Janejai N., Iamsirithaworn S., Lee R.T., Maurer-Stroh S.",57215524214;37076641700;56373922300;24492380600;35796265600;55337599200;35607457700;6602950054;8576571500;57212352148;8731901000;6506675753;8429537800;8937073300;57215524374;6602459149;,"Early transmission patterns of coronavirus disease 2019 (COVID-19) in travellers from Wuhan to Thailand, January 2020",2020,Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin,25,8,,,,,,10.2807/1560-7917.ES.2020.25.8.2000097,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081042361&doi=10.2807%2f1560-7917.ES.2020.25.8.2000097&partnerID=40&md5=d1a9af3ecc45ac021a3189d3f7ea5f63,"Department of Medical Sciences, Ministry of Public Health, Thailand; Department of Disease Control, Ministry of Public Health, Thailand; Thai Red Cross Emerging Infectious Diseases - Health Science Centre, Chulalongkorn University, Thailand; Bioinformatics Institute, Agency for Science Technology and Research, Singapore; Department of Biological Sciences, National University of Singapore, Singapore","Okada, P., Department of Medical Sciences, Ministry of Public Health, Thailand; Buathong, R., Department of Disease Control, Ministry of Public Health, Thailand; Phuygun, S., Department of Medical Sciences, Ministry of Public Health, Thailand; Thanadachakul, T., Department of Medical Sciences, Ministry of Public Health, Thailand; Parnmen, S., Department of Medical Sciences, Ministry of Public Health, Thailand; Wongboot, W., Department of Medical Sciences, Ministry of Public Health, Thailand; Waicharoen, S., Department of Medical Sciences, Ministry of Public Health, Thailand; Wacharapluesadee, S., Thai Red Cross Emerging Infectious Diseases - Health Science Centre, Chulalongkorn University, Thailand; Uttayamakul, S., Department of Disease Control, Ministry of Public Health, Thailand; Vachiraphan, A., Department of Disease Control, Ministry of Public Health, Thailand; Chittaganpitch, M., Department of Medical Sciences, Ministry of Public Health, Thailand; Mekha, N., Department of Medical Sciences, Ministry of Public Health, Thailand; Janejai, N., Department of Medical Sciences, Ministry of Public Health, Thailand; Iamsirithaworn, S., Department of Disease Control, Ministry of Public Health, Thailand; Lee, R.T., Bioinformatics Institute, Agency for Science Technology and Research, Singapore; Maurer-Stroh, S., Bioinformatics Institute, Agency for Science Technology and Research, Singapore, Department of Biological Sciences, National University of Singapore, Singapore","We report two cases of coronavirus disease 2019 (COVID-19) in travellers from Wuhan, China to Thailand. Both were independent introductions on separate flights, discovered with thermoscanners and confirmed with RT-PCR and genome sequencing. Both cases do not seem directly linked to the Huanan Seafood Market in Hubei but the viral genomes are identical to four other sequences from Wuhan, suggesting early spread within the city already in the first week of January.",coronavirus; COVID-19; SARS-CoV-2; transmission; traveller; Wuhan,"COVID-19; severe acute respiratory syndrome coronavirus 2; aged; anamnesis; Betacoronavirus; case report; China; chromosomal mapping; Coronavirus infection; epidemic; female; genetics; human; isolation and purification; middle aged; phylogeny; reverse transcription polymerase chain reaction; Thailand; travel; virus genome; virus pneumonia; Aged; Betacoronavirus; China; Chromosome Mapping; Coronavirus Infections; Disease Outbreaks; Female; Genome, Viral; Humans; Medical History Taking; Middle Aged; Phylogeny; Pneumonia, Viral; Reverse Transcriptase Polymerase Chain Reaction; Thailand; Travel",,,,NLM (Medline),15607917,,,32127124,English,Euro Surveill.,Article,Final,Open Access,Scopus,2-s2.0-85081042361,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Backer J.A., Klinkenberg D., Wallinga J.",34867835900;6603417925;7003807945;,"Incubation period of 2019 novel coronavirus (2019-nCoV) infections among travellers from Wuhan, China, 20-28 January 2020",2020,Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin,25,5,,,,,15,10.2807/1560-7917.ES.2020.25.5.2000062,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079336160&doi=10.2807%2f1560-7917.ES.2020.25.5.2000062&partnerID=40&md5=18340f6996d44ad1928b82509e2d2b39,"Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands; Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands","Backer, J.A., Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands; Klinkenberg, D., Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands; Wallinga, J., Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands","A novel coronavirus (2019-nCoV) is causing an outbreak of viral pneumonia that started in Wuhan, China. Using the travel history and symptom onset of 88 confirmed cases that were detected outside Wuhan in the early outbreak phase, we estimate the mean incubation period to be 6.4 days (95% credible interval: 5.6-7.7), ranging from 2.1 to 11.1 days (2.5th to 97.5th percentile). These values should help inform 2019-nCoV case definitions and appropriate quarantine durations.",2019-nCoV; exposure; incubation period; novel coronavirus; symptom onset; Wuhan,"COVID-19; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; China; Coronavirus infection; human; incubation time; pathogenicity; severe acute respiratory syndrome; travel; virus pneumonia; Betacoronavirus; China; Coronavirus Infections; Humans; Infectious Disease Incubation Period; Pneumonia, Viral; Severe Acute Respiratory Syndrome; Travel",,,,NLM (Medline),15607917,,,32046819,English,Euro Surveill.,Article,Final,Open Access,Scopus,2-s2.0-85079336160,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Peng J., Wang X., Yang M.-H., Wang M.-J., Zheng X.-R.",23111382300;57215115626;57215117962;57215126870;57215128842;,Management plan for prevention and control of novel coronavirus pneumonia among children in Xiangya Hospital of Central South University,2020,Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics,22,2,,100,105,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079336053&partnerID=40&md5=dacaa37c9f7018b917121c8e65d008c0,"Department of Pediatrics, Xiangya Hospital of Central South University, Changsha, 410008, China","Peng, J., Department of Pediatrics, Xiangya Hospital of Central South University, Changsha, 410008, China; Wang, X.; Yang, M.-H.; Wang, M.-J.; Zheng, X.-R.","Since December 2019, an epidemic of novel coronavirus pneumonia (NCP) has occurred in China. How to effectively prevent and control NCP among children with limited resources is an urgent issue to be explored. Under the unified arrangement of the Xiangya Hospital of Central South University, the Department of Pediatrics has formulated an action plan with Xiangya unique model to prevent and control NCP among children according to the current epidemic situation and diagnostic and therapeutic program in China.",,child; China; Coronavirinae; Coronavirus infection; human; pneumonia; university; Child; China; Coronavirus; Coronavirus Infections; Humans; Pneumonia; Universities,,,,NLM (Medline),10088830,,,32051074,Chinese,Zhongguo Dang Dai Er Ke Za Zhi,Article,Final,,Scopus,2-s2.0-85079336053,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Bordi L., Nicastri E., Scorzolini L., Di Caro A., Capobianchi M.R., Castilletti C., Lalle E., On Behalf Of Inmi Covid-Study Group And Collaborating Centers",8963521400;57211086423;6507358073;57208905168;57202594512;57211211954;23489455700;57215523821;,"Differential diagnosis of illness in patients under investigation for the novel coronavirus (SARS-CoV-2), Italy, February 2020",2020,Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin,25,8,,,,,,10.2807/1560-7917.ES.2020.25.8.2000170,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081041177&doi=10.2807%2f1560-7917.ES.2020.25.8.2000170&partnerID=40&md5=08583a48049adbb8b41cd174897515a8,"National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, Rome, Italy; participating members of INMI COVID-19 study group and Collaborating Centers are acknowledged at the end of the article","Bordi, L., National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, Rome, Italy; Nicastri, E., National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, Rome, Italy; Scorzolini, L., National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, Rome, Italy; Di Caro, A., National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, Rome, Italy; Capobianchi, M.R., National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, Rome, Italy; Castilletti, C., National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, Rome, Italy; Lalle, E., National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, Rome, Italy; On Behalf Of Inmi Covid-Study Group And Collaborating Centers, National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, Rome, Italy, participating members of INMI COVID-19 study group and Collaborating Centers are acknowledged at the end of the article","A novel coronavirus (SARS-CoV-2) has been identified as the causative pathogen of an ongoing outbreak of respiratory disease, now named COVID-19. Most cases and sustained transmission occurred in China, but travel-associated cases have been reported in other countries, including Europe and Italy. Since the symptoms are similar to other respiratory infections, differential diagnosis in travellers arriving from countries with wide-spread COVID-19 must include other more common infections such as influenza and other respiratory tract diseases.",differential diagnosis; rapid molecular assay; respiratory pathogens; SARS-CoV-2,"COVID-19; severe acute respiratory syndrome coronavirus 2; algorithm; Betacoronavirus; Coronavirus infection; differential diagnosis; epidemic; genetics; health survey; human; influenza; isolation and purification; Italy; mass screening; molecular diagnosis; procedures; respiratory tract infection; travel; virus pneumonia; Algorithms; Betacoronavirus; Coronavirus Infections; Diagnosis, Differential; Disease Outbreaks; Humans; Influenza, Human; Italy; Mass Screening; Molecular Diagnostic Techniques; Pneumonia, Viral; Population Surveillance; Respiratory Tract Infections; Travel",,,,NLM (Medline),15607917,,,32127123,English,Euro Surveill.,Article,Final,Open Access,Scopus,2-s2.0-85081041177,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Reusken C.B.E.M., Broberg E.K., Haagmans B., Meijer A., Corman V.M., Papa A., Charrel R., Drosten C., Koopmans M., Leitmeyer K., On Behalf Of Evd-LabNet And Erli-Net",6602366009;6603909215;6701371301;57061899200;34876424800;7103044603;57203046891;7003813990;7006736989;6603438416;57215385845;,"Laboratory readiness and response for novel coronavirus (2019-nCoV) in expert laboratories in 30 EU/EEA countries, January 2020",2020,Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin,25,6,,,,,1,10.2807/1560-7917.ES.2020.25.6.2000082,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080843760&doi=10.2807%2f1560-7917.ES.2020.25.6.2000082&partnerID=40&md5=330759161f3e21da5c3c6329568702cf,"Viroscience department, Erasmus MC, Rotterdam, Netherlands; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands; European Centre for Disease Prevention and Control, Solna, Sweden; German Centre for Infection Research (DZIF)Berlin, Germany; Charité - Universitätsmedizin Berlin Institute of VirologyBerlin, Germany; Department of Microbiology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece; Unité des Virus Emergents (Aix-Marseille Univ-IRD 190-Inserm 1207-IHU Méditerranée Infection), Marseille, France; participating members of EVD-LabNet and ERLI-Net are acknowledged at the end of the article","Reusken, C.B.E.M., Viroscience department, Erasmus MC, Rotterdam, Netherlands, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands; Broberg, E.K., European Centre for Disease Prevention and Control, Solna, Sweden; Haagmans, B., Viroscience department, Erasmus MC, Rotterdam, Netherlands; Meijer, A., Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands; Corman, V.M., German Centre for Infection Research (DZIF)Berlin, Germany, Charité - Universitätsmedizin Berlin Institute of VirologyBerlin, Germany; Papa, A., Department of Microbiology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece; Charrel, R., Unité des Virus Emergents (Aix-Marseille Univ-IRD 190-Inserm 1207-IHU Méditerranée Infection), Marseille, France; Drosten, C., German Centre for Infection Research (DZIF)Berlin, Germany, Charité - Universitätsmedizin Berlin Institute of VirologyBerlin, Germany; Koopmans, M., Viroscience department, Erasmus MC, Rotterdam, Netherlands; Leitmeyer, K., European Centre for Disease Prevention and Control, Solna, Sweden; On Behalf Of Evd-LabNet And Erli-Net, participating members of EVD-LabNet and ERLI-Net are acknowledged at the end of the article","Timely detection of novel coronavirus (2019-nCoV) infection cases is crucial to interrupt the spread of this virus. We assessed the required expertise and capacity for molecular detection of 2019-nCoV in specialised laboratories in 30 European Union/European Economic Area (EU/EEA) countries. Thirty-eight laboratories in 24 EU/EEA countries had diagnostic tests available by 29 January 2020. A coverage of all EU/EEA countries was expected by mid-February. Availability of primers/probes, positive controls and personnel were main implementation barriers.",2019-nCoV; coronavirus; emerging infections; laboratory; response; zoonoses,"COVID-19; virus RNA; classification; Coronavirinae; Coronavirus infection; epidemic; European Union; genetics; human; isolation and purification; laboratory; laboratory technique; procedures; reverse transcription polymerase chain reaction; sensitivity and specificity; sentinel surveillance; sequence analysis; standard; virology; virus pneumonia; Clinical Laboratory Techniques; Coronavirus; Coronavirus Infections; Disease Outbreaks; European Union; Humans; Laboratories; Pneumonia, Viral; Reference Standards; Reverse Transcriptase Polymerase Chain Reaction; RNA, Viral; Sensitivity and Specificity; Sentinel Surveillance; Sequence Analysis",,,,NLM (Medline),15607917,,,32046815,English,Euro Surveill.,Article,Final,Open Access,Scopus,2-s2.0-85080843760,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Kivistö I., Tidenberg E.-M., Lilley T., Suominen K., Forbes K.M., Vapalahti O., Huovilainen A., Sironen T.",56380644300;57214856604;12769882100;57214855155;55927206200;7003800146;6602666078;6507910298;,First Report of Coronaviruses in Northern European Bats,2020,Vector-Borne and Zoonotic Diseases,20,2,,155,158,,1,10.1089/vbz.2018.2367,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079320607&doi=10.1089%2fvbz.2018.2367&partnerID=40&md5=638c1a0c148b1b55186e1d7a46ed4af4,"Department of Virology, University of Helsinki, Helsinki, Finland; Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland; Zoology Unit, Finnish Museum of Natural History, Helsinki, Finland; Department of Biological Sciences, University of Arkansas, Fayetteville, AR, United States; Laboratory and Research Division, Finnish Food Authority, Helsinki, Finland","Kivistö, I., Department of Virology, University of Helsinki, Helsinki, Finland, Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland; Tidenberg, E.-M., Zoology Unit, Finnish Museum of Natural History, Helsinki, Finland; Lilley, T., Zoology Unit, Finnish Museum of Natural History, Helsinki, Finland; Suominen, K., Zoology Unit, Finnish Museum of Natural History, Helsinki, Finland; Forbes, K.M., Department of Biological Sciences, University of Arkansas, Fayetteville, AR, United States; Vapalahti, O., Department of Virology, University of Helsinki, Helsinki, Finland, Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland; Huovilainen, A., Laboratory and Research Division, Finnish Food Authority, Helsinki, Finland; Sironen, T., Department of Virology, University of Helsinki, Helsinki, Finland, Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland","Coronaviruses (CoVs) represent a global public health threat, exemplified by the severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) outbreaks. Using fecal samples collected from five bat species between 2014 and 2016 in Finland and RT-PCR, RT-qPCR, and NGS, we identified CoVs in 10 of 79 (13%) samples, including two novel bat species-CoV relationships. Phylogenetic analysis revealed Alphacoronavirus and Betacoronavirus species clustered among previously identified bat and human viruses. These results expand the known northern distribution and host species range of bat-borne CoVs. © Copyright 2020, Mary Ann Liebert, Inc.",Chiroptera; coronavirus; Finland,Alphacoronavirus; article; bat; Betacoronavirus; feces; Finland; human; nonhuman; phylogeny; polymerase chain reaction,"Ch, C., Childs, J.E., Holmes, K.V., Schountz, T., Bats: Important reservoir hosts of emerging viruses (2006) Clin Microbiol Rev, 19, pp. 531-545; De Souza Luna, L.K., Heiser, V., Regamey, N., Panning, M., Generic detection of coronaviruses and differentiation at the prototype strain level by reverse transcription-PCR and nonfluorescent low-density microarray (2007) J Clin Microbiol, 45, pp. 1049-1052; Drexler, J.F., Corman, V.M., Drosten, C., Ecology, evolution and classification of bat coronaviruses in the aftermath of SARS (2014) Antiviral Res, 101, pp. 45-56; Forbes, W., Bombali virus in Mops condylurus bat, Kenya (2019) Emerg Infect Dis, 25, pp. 955-957; Kunz, T.H., Braun De Torrez, E., Bauer, D., Lobova, T., Ecosystem services provided by bats (2011) Ann N y Acad Sci, 1223, pp. 1-38; Laine, V.N., Lilley, T.M., Norrdahl, K., Primmer, C.R., Population genetics of Daubenton's bat (Myotis daubentonii) in the Archipelago Sea, SW Finland (2013) Ann Zool Fennici, 50, pp. 303-315; Muradrasoli S, M., Broadly targeted multiprobe QPCR for detection of coronaviruses: Coronavirus is common among mallard ducks (Anas platyrhynchos) (2009) J Virol Methods, 159, pp. 277-287; Okonechnikov, K., Golosova, O., Fursov, M., Unipro UGENE: A unified bioinformatics toolkit (2012) Bioinformatics, 28, pp. 1166-1167; Ronquist, F., Teslenko, M., Van Der Mark, P., Ayres, D.L., MrBayes 3.2: Efficient Bayesian phylogenetic inference and model choice across a large model space (2012) Syst Biol, 61, pp. 539-542; Ruedi, M., Stadelmann, B., Gager, Y., Douzery, E.J., Molecular phylogenetic reconstructions identify East Asia as the cradle for the evolution of the cosmopolitan genus Myotis (Mammalia, Chiroptera) (2013) Mol Phylogenet Evol, 69, pp. 437-449; Woo, P.C., Lau, S.K., Lam, C.S., Lau, C.C., Discovery of seven novel mammalian and avian coronaviruses in Deltacoronavirus supports bat coronaviruses as the gene source of Alphacoronavirus and Betacoronavirus and avian coronaviruses as the gene source of Gammacoronavirus and Deltacoronavirus (2012) J Virol, 86, pp. 3995-4008; Woo, P.C., Lau, S.K., Li, K.S., Poon, R.W., Molecular diversity of coronaviruses in bats (2006) Virology, 351, pp. 180-187","Kivistö, I.; Department of Virology, University of Helsinki, PO Box 21, Finland; email: ilkka.kivisto@helsinki.fi",,Mary Ann Liebert Inc.,15303667,,VZDEB,31503522,English,Vector Borne Zoonotic Dis.,Article,Final,Open Access,Scopus,2-s2.0-85079320607,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Pediatric Committee, Medical Association of Chinese People's Liberation Army, Editorial Committee of Chinese Journal of Contemporary Pediatrics",,Emergency response plan for the neonatal intensive care unit during epidemic of 2019 novel coronavirus,2020,Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics,22,2,,91,95,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079336498&partnerID=40&md5=5f6ef75a8e54220e39f15dd2cc8568ca,,"Pediatric Committee, Medical Association of Chinese People's Liberation Army; Editorial Committee of Chinese Journal of Contemporary Pediatrics","2019 novel coronavirus (2019-nCoV) infection has been spreading in China since December 2019. Neonates are presumably the high-risk population susceptible to 2019-nCoV due to immature immune function. The neonatal intensive care unit (NICU) should be prepared for 2019-nCoV infections as far as possible. The emergency response plan enables the efficient response capability of NICU. During the epidemic of 2019-nCoV, the emergency response plan for the NICU should be based on the actual situation, including diagnosis, isolation, and treatment, as well as available equipment and staffing, and take into account the psychosocial needs of the families and neonatal care staff.",,"China; Coronavirinae; human; neonatal intensive care unit; newborn; risk factor; China; Coronavirus; Humans; Infant, Newborn; Intensive Care Units, Neonatal; Risk Factors",,,,NLM (Medline),10088830,,,32051072,Chinese,Zhongguo Dang Dai Er Ke Za Zhi,Article,Final,,Scopus,2-s2.0-85079336498,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Xu X.-W., Wu X.-X., Jiang X.-G., Xu K.-J., Ying L.-J., Ma C.-L., Li S.-B., Wang H.-Y., Zhang S., Gao H.-N., Sheng J.-F., Cai H.-L., Qiu Y.-Q., Li L.-J.",55706237200;57215071906;56666287600;8513212000;57215037541;57215045367;55741009200;57215068776;57215062681;57215070745;7202784409;57215064665;57215071135;57196183416;,"Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: Retrospective case series",2020,The BMJ,368,, m606,,,,15,10.1136/bmj.m606,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079760608&doi=10.1136%2fbmj.m606&partnerID=40&md5=24a52da43031b7aaf2956e63619e23fe,"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Centre for Infectious Diseases, Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, 310003, China; Department of Infectious Disease, Wenzhou Central Hospital, Wenzhou, Zhejiang Province, China; Department of Infectious Disease, Taizhou Enze Medical Centre (Group), Enze Hospital, Taizhou, Zhejiang Province, China; Department of Infectious Disease, First People's Hospital of Wenling, Wenling, Zhejiang Province, China; Department of Infectious Disease, Affiliated Zhoushan Hospital, Wenzhou Medical University, Zhoushan, Zhejiang Province, China; Department of Respiratory and Critical Care Medicine, Yinzhou People's Hospital, Affiliated Yinzhou Hospital, College of Medicine, Ningbo University, Ningbo City, Zhejiang Province, China; Department of Infectious Disease, Taizhou Hospital, Taizhou, Zhejiang Province, China; Department of Infectious Disease, ShuLan Hospital Affiliated to Zhejiang Shuren University Shulan International Medical College, Hangzhou, Zhejiang Province, China","Xu, X.-W., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Centre for Infectious Diseases, Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, 310003, China; Wu, X.-X., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Centre for Infectious Diseases, Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, 310003, China; Jiang, X.-G., Department of Infectious Disease, Wenzhou Central Hospital, Wenzhou, Zhejiang Province, China; Xu, K.-J., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Centre for Infectious Diseases, Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, 310003, China; Ying, L.-J., Department of Infectious Disease, Taizhou Enze Medical Centre (Group), Enze Hospital, Taizhou, Zhejiang Province, China; Ma, C.-L., Department of Infectious Disease, First People's Hospital of Wenling, Wenling, Zhejiang Province, China; Li, S.-B., Department of Infectious Disease, Affiliated Zhoushan Hospital, Wenzhou Medical University, Zhoushan, Zhejiang Province, China; Wang, H.-Y., Department of Respiratory and Critical Care Medicine, Yinzhou People's Hospital, Affiliated Yinzhou Hospital, College of Medicine, Ningbo University, Ningbo City, Zhejiang Province, China; Zhang, S., Department of Infectious Disease, Taizhou Hospital, Taizhou, Zhejiang Province, China; Gao, H.-N., Department of Infectious Disease, ShuLan Hospital Affiliated to Zhejiang Shuren University Shulan International Medical College, Hangzhou, Zhejiang Province, China; Sheng, J.-F., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Centre for Infectious Diseases, Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, 310003, China; Cai, H.-L., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Centre for Infectious Diseases, Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, 310003, China; Qiu, Y.-Q., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Centre for Infectious Diseases, Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, 310003, China; Li, L.-J., State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Centre for Infectious Diseases, Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, 310003, China","AbstractObjective To study the clinical characteristics of patients in Zhejiang province, China, infected with the 2019 severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) responsible for coronavirus disease 2019 (covid-2019). Design Retrospective case series. Setting Seven hospitals in Zhejiang province, China. Participants 62 patients admitted to hospital with laboratory confirmed SARS-Cov-2 infection. Data were collected from 10 January 2020 to 26 January 2020. Main outcome measures Clinical data, collected using a standardised case report form, such as temperature, history of exposure, incubation period. If information was not clear, the working group in Hangzhou contacted the doctor responsible for treating the patient for clarification. Results Of the 62 patients studied (median age 41 years), only one was admitted to an intensive care unit, and no patients died during the study. According to research, none of the infected patients in Zhejiang province were ever exposed to the Huanan seafood market, the original source of the virus; all studied cases were infected by human to human transmission. The most common symptoms at onset of illness were fever in 48 (77%) patients, cough in 50 (81%), expectoration in 35 (56%), headache in 21 (34%), myalgia or fatigue in 32 (52%), diarrhoea in 3 (8%), and haemoptysis in 2 (3%). Only two patients (3%) developed shortness of breath on admission. The median time from exposure to onset of illness was 4 days (interquartile range 3-5 days), and from onset of symptoms to first hospital admission was 2 (1-4) days. Conclusion As of early February 2020, compared with patients initially infected with SARS-Cov-2 in Wuhan, the symptoms of patients in Zhejiang province are relatively mild. © Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to.",,"adolescent; adult; child; China; clinical trial; Coronavirus infection; coughing; female; fever; human; male; middle aged; multicenter study; prognosis; retrospective study; severe acute respiratory syndrome; thorax radiography; virology; x-ray computed tomography; young adult; Adolescent; Adult; Child; China; Coronavirus Infections; Cough; Female; Fever; Humans; Male; Middle Aged; Prognosis; Radiography, Thoracic; Retrospective Studies; Severe Acute Respiratory Syndrome; Tomography, X-Ray Computed; Young Adult","Clinical Management of Severe Acute Respiratory Infection When Novel Coronavirus (NCoV) Infection Is Suspected: Interim Guidance, , https://www.who.int/publications-detail/clinical-management-of-severe-acute-respiratory-infection-whennovel-coronavirus-(ncov)-infection-is-suspected, WHO. Jan 11, 2020; Lu, H., Stratton, C.W., Tang, Y.W., Outbreak of Pneumonia of Unknown Etiology in Wuhan China: The Mystery and the Miracle (2020) J Med Virol, , published online 16 January; Ji, W., Wang, W., Zhao, X., Zai, J., Li, X., Homologous recombination within the spike glycoprotein of the newly identified coronavirus may boost cross-species transmission from snake to human (2020) J Med Virol, , published online 22 January; De Groot, R.J., Baker, S.C., Baric, R.S., Middle East respiratory syndrome coronavirus (MERS-CoV): Announcement of the Coronavirus Study Group (2013) J Virol, 87, pp. 7790-7792; Zaki, A.M., Van Boheemen, S., Bestebroer, T.M., Osterhaus, A.D., Fouchier, R.A., Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia (2012) N Engl J Med, 367, pp. 1814-1820; Lu, R., Zhao, X., Li, J., Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding (2020) Lancet, , published online 30 January; (2019) Middle East Respiratory Syndrome Coronavirus (MERS-CoV), , https://www.who.int/emergencies/mers-cov/en/, WHO. November (accessed Jan 19, 2020); Xu, X., Chen, P., Wang, J., Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission (2020) Sci China Life Sci; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, , published online 24 January; Jf-W, C., Yuan, S., Kok, K.-H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating personto-person transmission: A study of a family cluster (2020) Lancet, , Published online January 24; Novel Coronavirus (2019-nCoV). Situation report-5. 25 January 2020, , www.who.int/docs/default-source/coronaviruse/situation-reports/20200125-sitrep-5-2019-ncov.pdf?sfvrsn=429b143d-4, World Health Organization; www.chinacdc.cn/jkzt/crb/zl/szkb-11803/jszl-11811/202001/P020200127544648420736.pdf(InChinese); Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study (2020) Lancet, , published online 30 January; Kim, K.H., Tandi, T.E., Choi, J.W., Moon, J.M., Kim, M.S., Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak in South Korea, 2015: Epidemiology, characteristics and public health implications (2017) J Hosp Infect, 95, pp. 207-213; Middle East Respiratory Syndrome Coronavirus (MERS-CoV), , https://www.who.int/emergencies/mers-cov/en/.(accessedJan27,2020); Chu, C.M., Cheng, V.C., Hung, I.F., Role of lopinavir/ritonavir in the treatment of SARS: Initial virological and clinical findings[published Online First: 2004/02/27] (2004) Thorax, 59, pp. 252-256. , HKU/UCH SARS Study Group","Li, L.-J.; State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Centre for Infectious Diseases, Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang UniversityChina; email: ljli@zju.edu.cn",,BMJ Publishing Group,9598146,,BMJOA,32075786,English,BMJ,Article,Final,Open Access,Scopus,2-s2.0-85079760608,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Working Group for the Prevention and Control of Neonatal 2019-nCoV Infection in the Perinatal Period of the Editorial Committee of Chinese Journal of Contemporary Pediatrics,,Perinatal and neonatal management plan for prevention and control of 2019 novel coronavirus infection (1st Edition),2020,Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics,22,2,,87,90,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079334646&partnerID=40&md5=26cc5b64d24a2c74f02557354c0d7b0d,,Working Group for the Prevention and Control of Neonatal 2019-nCoV Infection in the Perinatal Period of the Editorial Committee of Chinese Journal of Contemporary Pediatrics,"Since December 2019, the novel coronavirus (2019-nCoV) infection has been prevalent in China. Due to immaturity of immune function and the possibility of mother-fetal vertical transmission, neonates are particularly susceptible to 2019-nCoV. The perinatal-neonatal departments should cooperate closely and take integrated approaches, and the neonatal intensive care unit should prepare the emergency plan for 2019-nCoV infection as far as possible, so as to ensure the optimal management and treatment of potential victims. According to the latest 2019-nCoV national management plan and the actual situation, the Working Group for the Prevention and Control of Neonatal 2019-nCoV Infection in the Perinatal Period of the Editorial Committee of Chinese Journal of Contemporary Pediatrics puts forward recommendations for the prevention and control of 2019-nCoV infection in neonates.",,"child; China; Coronavirus infection; female; human; neonatal intensive care unit; newborn; pregnancy; vertical transmission; Child; China; Coronavirus Infections; Female; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Intensive Care Units, Neonatal; Pregnancy",,,,NLM (Medline),10088830,,,32051071,Chinese,Zhongguo Dang Dai Er Ke Za Zhi,Article,Final,,Scopus,2-s2.0-85079334646,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Pediatric Branch of Hubei Medical Association, Pediatric Branch of Wuhan Medical Association, Pediatric Medical Quality Control Center of Hubei",,Recommendation for the diagnosis and treatment of novel coronavirus infection in children in Hubei (Trial version 1),2020,Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics,22,2,,96,99,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079336019&partnerID=40&md5=d6969729843f21bc2a39797445a9c617,,Pediatric Branch of Hubei Medical Association; Pediatric Branch of Wuhan Medical Association; Pediatric Medical Quality Control Center of Hubei,"Since December 2019, a cluster of patients have been diagnosed to be infected with 2019 novel coronavirus (2019-nCoV) in Wuhan, China. The epidemic has been spreading to other areas of the country and abroad. A few cases have progressed rapidly to acute respiratory distress syndrome and/or multiple organ function failure. The epidemiological survey has indicated that the general population is susceptible to 2019-nCoV. A total of 14 children (6 months to 14 years of age, including 5 cases in Wuhan) have been confirmed to be infected with 2019-nCoV in China so far. In order to further standardize and enhance the clinical management of 2019-nCoV infection in children, reduce the incidence, and decrease the number of severe cases, we have formulated this diagnosis and treatment recommendation according to the recent information at home and abroad.",,"adolescent; child; China; Coronavirinae; Coronavirus infection; human; infant; multiple organ failure; preschool child; Adolescent; Child; Child, Preschool; China; Coronavirus; Coronavirus Infections; Humans; Infant; Multiple Organ Failure",,,,NLM (Medline),10088830,,,32051073,Chinese,Zhongguo Dang Dai Er Ke Za Zhi,Article,Final,,Scopus,2-s2.0-85079336019,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhou T., Liu Q., Yang Z., Liao J., Yang K., Bai W., Lu X., Zhang W.",56449913600;57189325700;57214896434;57214886439;57214896400;57214898731;57191611185;57215936623;,Preliminary prediction of the basic reproduction number of the Wuhan novel coronavirus 2019-nCoV,2020,Journal of Evidence-Based Medicine,13,1,,3,7,,,10.1111/jebm.12376,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079451848&doi=10.1111%2fjebm.12376&partnerID=40&md5=64ca3ee69193b58716352cfc2e2a40e8,"Big Data Research Center, University of Electronic Science and Technology of China, Chengdu, 611731, China; College of Computer Science, Sichuan University, Chengdu, 610065, China; Beijing AiQiYi Science & Technology Co. Ltd., Beijing, 100080, China; Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China; CompleX Lab, University of Electronic Science and Technology of China, Chengdu, 611731, China; College of Systems Engineering, National University of Defense Technology, Changsha, 410073, China; West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, 610047, China","Zhou, T., Big Data Research Center, University of Electronic Science and Technology of China, Chengdu, 611731, China; Liu, Q., College of Computer Science, Sichuan University, Chengdu, 610065, China; Yang, Z., Beijing AiQiYi Science & Technology Co. Ltd., Beijing, 100080, China; Liao, J., Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China; Yang, K., College of Computer Science, Sichuan University, Chengdu, 610065, China; Bai, W., CompleX Lab, University of Electronic Science and Technology of China, Chengdu, 611731, China; Lu, X., College of Systems Engineering, National University of Defense Technology, Changsha, 410073, China; Zhang, W., West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, 610047, China","Objectives: To estimate the basic reproduction number of the Wuhan novel coronavirus (2019-nCoV). Methods: Based on the susceptible-exposed-infected-removed (SEIR) compartment model and the assumption that the infectious cases with symptoms occurred before 26 January, 2020 are resulted from free propagation without intervention, we estimate the basic reproduction number of 2019-nCoV according to the reported confirmed cases and suspected cases, as well as the theoretical estimated number of infected cases by other research teams, together with some epidemiological determinants learned from the severe acute respiratory syndrome (SARS). Results: The basic reproduction number fall between 2.8 and 3.3 by using the real-time reports on the number of 2019-nCoV-infected cases from People's Daily in China and fall between 3.2 and 3.9 on the basis of the predicted number of infected cases from international colleagues. Conclusions: The early transmission ability of 2019-nCoV is close to or slightly higher than SARS. It is a controllable disease with moderate to high transmissibility. Timely and effective control measures are needed to prevent the further transmissions. © 2020 Chinese Cochrane Center, West China Hospital of Sichuan University and John Wiley & Sons Australia, Ltd",2019 novel coronavirus (2019-nCoV); basic reproduction number; epidemiology,"Article; basic reproduction number; China; Coronavirinae; epidemic; human; infection control; infection prevention; nonhuman; prediction; priority journal; sensitivity analysis; severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; virus transmission; Betacoronavirus; Coronavirus infection; forecasting; theoretical model; virus pneumonia; COVID-19; severe acute respiratory syndrome coronavirus 2; Basic Reproduction Number; Betacoronavirus; China; Coronavirus Infections; Forecasting; Humans; Models, Theoretical; Pneumonia, Viral","Adnerson, R.M., May, R.M., (1991) Infectious Diseases of Humans: Dynamics and Control, , Oxford, Oxford University Press; Chinazzi, M., Davis, J.T., Gioannini, C., (2020) Series reports entitled “preliminary assessment of the international spreading risk associated with the 2019 novel coronavirus outbreak in Wuhan City, , ” Unpublished; Donnelly, C.A., Ghani, A.C., Leung, G.M., Epidemiological determinants of spread of causal agent of severe acute respiratory syndromein Hong Kong (2003) Lancet, 361, pp. 1761-1766; Chan, J.F.W., Yuan, S., Kok, K.H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, , https://doi.org/10.1016/S0140-6736(20)30154-9; Pastor-Satorras, R., Castellano, C., Mieghem, P.V., Epidemic processes in complex networks (2015) Rev Mod Phys, 87 (3), pp. 925-979; Wallinga, J., Lipsitch, M., How generation intervals shape the relationship between growth rates and reproductive numbers (2007) Proc R Soc B: Biol Sci, 274 (1609), pp. 599-604; Imai, N., Dorigatti, I., Cori, A., Series reports entitled “Estimating the potential total number of novel coronavirus in Wuhan City, China.”, , Unpublished; Read, J.M., Bridgen, J.R.E., Cummings, D.A.T., Novel coronavirus 2019-nCoV: early estimation of epidemiological parameters and epidemic predictions (2020) Preprint. MedRXiv, , http://doi.org/10.1101/2020.01.23.20018549; Leo, Y.S., Chen, M., Heng, B.H., Severe acute respiratory syndrome—Singapore 2003 (2003) Morb Mortal Weekly Report, 52 (18), pp. 405-432; Lipsitch, M., Cohen, T., Cooper, B., Transmission dynamics and control of severe acute respiratory syndrome (2003) Science, 300 (5627), pp. 1966-1970; Imai, N., Cori, A., Dorigatti, I., (2020) Transmissibility of 2019-nCoV, , Unpublished; Riley, S., Transmission dynamics of the etiological agent of SARS in Hong Kong: impact of public health interventions (2003) Science, 300 (5627), pp. 1961-1966; Wallinga, J., Teunis, P., Different epidemic curves for severe acute respiratory syndrome reveal similar impacts of control measures (2004) Am J Epidemiol, 160 (6), pp. 509-517; Lessler, J., Chaisson, L.H., Kucirka, L.M., Assessing the global threat from Zika virus (2016) Science, 353; Majumder, M.S., Rivers, C., Lofgren, E., Estimation of MERS-coronavirus reproductive number and case fatality rate for the spring 2014 Saudi Arabia outbreak: insights from publicly available data (2014) PLoS Curr, 6; Eichner, M., Dietz, K., Transmission potential of smallpox: estimates based on detailed data from an outbreak (2003) Am J Epidemiol, 158 (2), pp. 110-117; Balcan, D., Gonçalves, B., Hu, H., Modeling the spatial spread of infectious diseases: the Global Epidemic and Mobility computational model (2010) J Com Sci, 1 (3), pp. 132-145; Brockmann, D., Helbing, D., The hidden geometry of complex, network-driven contagion phenomena (2013) Science, 342 (6164), pp. 1337-1342; Bengtsson, L., Gaudart, J., Lu, X., Using mobile phone data to predict the spatial spread of cholera (2015) Sci Rep, 5, p. 8923; Liu, Q.H., Ajelli, M., Aleta, A., Measurability of the epidemic reproduction number in data-driven contact networks (2018) Proc Natl Acad Sci USA, 115 (50), pp. 12680-12685","Liu, Q.; College of Computer Science, Sichuan UniversityChina; email: quanhuiliu@scu.edu.cn",,Blackwell Publishing,17565383,,,32048815,English,J. Evid.-Based Med.,Article,Final,Open Access,Scopus,2-s2.0-85079451848,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Burimuah V., Sylverken A., Owusu M., El-Duah P., Yeboah R., Lamptey J., Frimpong Y.O., Agbenyega O., Folitse R., Tasiame W., Emikpe B., Owiredu E.-W., Oppong S., Adu-Sarkodie Y., Drosten C.",57189049493;56674665700;54584146300;56503967700;57205400278;57205401700;56376174200;25222419700;55893471600;57046065900;55316246200;57201687869;6603094509;57201303125;7003813990;,"Sero-prevalence, cross-species infection and serological determinants of prevalence of Bovine Coronavirus in Cattle, Sheep and Goats in Ghana",2020,Veterinary Microbiology,241,,108544,,,,,10.1016/j.vetmic.2019.108544,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85076371802&doi=10.1016%2fj.vetmic.2019.108544&partnerID=40&md5=6899475090a7ea46d195b8684e292040,"Department of Clinical Microbiology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; School of Veterinary Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Department of Theoretical and Applied Biology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana; Department of Medical Laboratory Technology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Institute of Virology, Charite, Universitätsmedizin Berlin, Germany; Department of Animal Science, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Department of Agroforestry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Department of Molecular Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Department of Wildlife and Range Management, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana","Burimuah, V., Department of Clinical Microbiology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana, School of Veterinary Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Sylverken, A., Department of Theoretical and Applied Biology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana, Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana; Owusu, M., Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana, Department of Medical Laboratory Technology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; El-Duah, P., Department of Clinical Microbiology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana, Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana, Institute of Virology, Charite, Universitätsmedizin Berlin, Germany; Yeboah, R., Department of Clinical Microbiology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana, Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana; Lamptey, J., Department of Clinical Microbiology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana, Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana; Frimpong, Y.O., Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana, Department of Animal Science, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Agbenyega, O., Department of Agroforestry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Folitse, R., School of Veterinary Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Tasiame, W., School of Veterinary Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana, Institute of Virology, Charite, Universitätsmedizin Berlin, Germany; Emikpe, B., School of Veterinary Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Owiredu, E.-W., Department of Molecular Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Oppong, S., Department of Wildlife and Range Management, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Adu-Sarkodie, Y., Department of Clinical Microbiology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Drosten, C., Institute of Virology, Charite, Universitätsmedizin Berlin, Germany","Cattle, goats and sheep are dominant livestock species in sub-Saharan Africa, with sometimes limited information on the prevalence of major infectious diseases. Restrictions due to notifiable epizootics complicate the exchange of samples in surveillance studies and suggest that laboratory capacities should be established domestically. Bovine Coronavirus (BCoV) causes mainly enteric disease in cattle. Spillover to small ruminants is possible. Here we established BCoV serology based on a recombinant immunofluorescence assay for cattle, goats and sheep, and studied the seroprevalence of BCoV in these species in four different locations in the Greater Accra, Volta, Upper East, and Northern provinces of Ghana. The whole sampling and testing was organized and conducted by a veterinary school in Kumasi, Ashanti Region of Ghana. Among sampled sheep (n = 102), goats (n = 66), and cattle (n = 1495), the seroprevalence rates were 25.8 %, 43.1 % and 55.8 %. For cattle, seroprevalence was significantly higher on larger farms (82.2 % vs 17.8 %, comparing farms with >50 or <50 animals; p = 0.027). Highest prevalence was seen in the Northern province with dry climate, but no significant trend following the north-south gradient of sampling sites was detected. Our study identifies a considerable seroprevalence for BCoV in Ghana and provides further support for the spillover of BCoV to small ruminants in settings with mixed husbandry and limited separation between species. © 2019",Africa; Bovine Coronavirus; Ghana; Global health,adult; agricultural land; Article; bovine; Bovine coronavirus infection; climate; Coronavirus infection; female; Ghana; goat; immunofluorescence test; male; nonhuman; risk factor; serology; seroprevalence; sheep; weaner,"Alkan, F., Bilge-Dağalp, S., Can Şahna, K., Özgünlük, İ., Sığırlarda coronavirus enfeksiyonunun epidemiyolojisi (2003) Ankara Üniv Vet Fak Derg., 50, pp. 59-64; Beaudeau, F., Björkman, C., Alenius, S., Frössling, J., Spatial patterns of bovine corona virus and bovine respiratory syncytial virus in the Swedish beef cattle population (2010) Acta Vet. Scand., 52 (1), p. 33; Bidokhti, M.R., Tråvén, M., Fall, N., Emanuelson, U., Alenius, S., Reduced likelihood of bovine coronavirus and bovine respiratory syncytial virus infection on organic compared to conventional dairy farms (2009) Vet. J., 182 (3), pp. 436-440; Boileau, M.J., Kapil, S., Bovine coronavirus associated syndromes (2010) Veterinary Clinics: Food Animal Practice, 26 (1), pp. 123-146; Clark, M., Bovine coronavirus (1993) Br. Vet. J., 149 (1), pp. 51-70; Durham, P., Stevenson, B., Farquharson, B., Rotavirus and coronavirus associated diarrhoea in domestic animals (1979) N. Z. Vet. J., 27, pp. 30-32; Eisa, M., Mohamed, A., Role of enteric pathogens in enteritis in lambs, goat kids and children and their zoonotic importance (2004) Vet Med J Giza., 52, pp. 41-59; El-Duah, P., Sylverken, A., Owusu, M., Yeboah, R., Lamptey, J., Frimpong, Y.O., Potential intermediate hosts for coronavirus transmission: No evidence of clade 2c coronaviruses in domestic livestock from Ghana (2019) Trop. Med. Infect. Dis., 4 (1), p. 34; El-Ghorr, A., Snodgrass, D., Scott, F., Campbell, I., A serological comparison of bovine coronavirus strains (1989) Arch. Virol., 104 (3-4), pp. 241-248; Gumusova, O., Yazici, Z., Albayrak, H., Çakiroglu, D., First report of bovine rotavirus and bovine coronavirus seroprevalance in goats in Turkey (2007) Vet glasnik, 61, pp. 75-79; Hägglund, S., Svensson, C., Emanuelson, U., Valarcher, J., Alenius, S., Dynamics of virus infections involved in the bovine respiratory disease complex in Swedish dairy herds (2006) Vet. J., 172 (2), pp. 320-328; Hasoksuz, M., Hoet, A.E., Loerch, S.C., Wittum, T.E., Nielsen, P.R., Saif, L.J., Detection of respiratory and enteric shedding of bovine coronaviruses in cattle in an Ohio feedlot (2002) J. Vet. Diagn. Investig., 14 (4), pp. 308-313; Hasoksuz, M., Kayar, A., Dodurka, T., Ilgaz, A., Detection of respiratory and enteric shedding of bovine coronaviruses in cattle in Northwestern Turkey (2005) Acta Vet. Hung., 53 (1), pp. 137-146; Hoye, B.J., Munster, V.J., Nishiura, H., Klaassen, M., Fouchier, R.A., Surveillance of wild birds for avian influenza virus (2010) Emerg Infect Dis., 16 (12), p. 1827; Kapil, S., Trent, A.M., Goyal, S.M., Excretion and persistence of bovine coronavirus in neonatal calves (1990) Arch. Virol., 115 (1-2), pp. 127-132; Ksiazek, T.G., Erdman, D., Goldsmith, C.S., Zaki, S.R., Peret, T., Emery, S., A novel coronavirus associated with severe acute respiratory syndrome (2003) N. Engl. J. Med., 348 (20), pp. 1953-1966; Lathrop, S.L., Wittum, T.E., Brock, K.V., Loerch, S.C., Perino, L.J., Bingham, H.R., Association between infection of the respiratory tract attributable to bovine coronavirus and health and growth performance of cattle in feedlots (2000) Am. J. Vet. Res., 61 (9), pp. 1062-1066; Lathrop, S.L., Wittum, T.E., Loerch, S.C., Perino, L.J., Saif, L.J., Antibody titers against bovine coronavirus and shedding of the virus via the respiratory tract in feedlot cattle (2000) Am. J. Vet. Res., 61 (9), pp. 1057-1061; Meyer, B., Müller, M.A., Corman, V.M., Reusken, C.B., Ritz, D., Godeke, G.J., Antibodies against MERS coronavirus in dromedaries, United Arab Emirates, 2003 and 2013 (2014) Emerg Infect Dis., 20 (4), pp. 552-559; O'Connor, A., Martin, S.W., Nagy, E., Menzies, P., Harland, R., The relationship between the occurrence of undifferentiated bovine respiratory disease and titer changes to bovine coronavirus and bovine viral diarrhea virus in 3 Ontario feedlots (2001) Can. J. Vet. Res., 65 (3), p. 137; Ohlson, A., Heuer, C., Lockhart, C., Tråvén, M., Emanuelson, U., Alenius, S., Risk factors for seropositivity to bovine coronavirus and bovine respiratory syncytial virus in dairy herds (2010) Vet. Rec., 167 (6), pp. 201-207; Oma, V.S., Tråvén, M., Alenius, S., Myrmel, M., Stokstad, M., Bovine coronavirus in naturally and experimentally exposed calves; viral shedding and the potential for transmission (2016) Virol. J., 13 (1), p. 100; Park, S., Kim, G., Choy, H., Hong, Y., Saif, L., Jeong, J., Dual enteric and respiratory tropisms of winter dysentery bovine coronavirus in calves (2007) Arch. Virol., 152 (10), pp. 1885-1900; Pass, D., Penhale, W., Wilcox, G., Batey, R., Intestinal coronavirus-like particles in sheep with diarrhoea (1982) Vet. Rec., 111, pp. 106-107; Pfefferle, S., Oppong, S., Drexler, J.F., Gloza-Rausch, F., Ipsen, A., Seebens, A., Distant relatives of severe acute respiratory syndrome coronavirus and close relatives of human coronavirus 229E in bats, Ghana (2009) Emerging Infect. Dis., 15 (9), p. 1377; Reinhardt, G., Zamora, J., Tadich, N., Polette, M., Aguilar, M., Riedermann, S., Diagnosis of coronavirus in sheep in Valdidia province, X region, Chile (1995) Arch. Med. Vet., 27, pp. 129-132; Reusken, C., Ababneh, M., Raj, V., Meyer, B., Eljarah, A., Abutarbush, S., Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Serology in Major Livestock Species in an Affected Region in Jordan, June to September 2013 (2013); Reusken, C.B., Haagmans, B.L., Müller, M.A., Gutierrez, C., Godeke, G.-J., Meyer, B., Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study (2013) Lancet Infect. Dis., 13 (10), pp. 859-866; Snodgrass, D., Herring, J., Reid, H., Scott, F., Gray, E., Virus infections in cattle and sheep in Scotland 1975–1978 (1980) Vet. Rec., 106, pp. 193-195; Tråvén, M., Carlsson, U., Lundén, A., Larsson, B., Serum antibodies to bovine coronavirus in Swedish sheep (1999) Acta Vet. Scand., 40, pp. 69-74; Vijgen, L., Keyaerts, E., Lemey, P., Maes, P., Van Reeth, K., Nauwynck, H., Evolutionary history of the closely related group 2 coronaviruses: porcine hemagglutinating encephalomyelitis virus, bovine coronavirus, and human coronavirus OC43 (2006) J. Virol., 80 (14), pp. 7270-7274; Yang, D., Leibowitz, J.L., The structure and functions of coronavirus genomic 3′ and 5′ ends (2015) Virus Res., 206, pp. 120-133; Yavru, S., Yapici, O., Kale, M., Sahinduran, S., Pehlivanoglu, F., Albay, M.K., Bovine coronavirus (BoCV) infection in calves with diarrhoea and their dams (2016) Acta Sci. Vet., 44, pp. 1-7; Yildirim, Y., Dagalp, S.B., Tan, M.T., Kalaycioglu, A.T., Seroprevalence of the rotavirus and corona virus infections in cattle (2008) J. Anim. Vet. Adv., 7 (10), pp. 1320-1323","Drosten, C.; Charité, Universitätsmedizin Berlin, Institute of Virology, Charitéplatz 1, Germany; email: Christian.drosten@charite.de",,Elsevier B.V.,3781135,,VMICD,31928696,English,Vet. Microbiol.,Article,Final,Open Access,Scopus,2-s2.0-85076371802,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Stranieri A., Probo M., Pisu M.C., Fioletti A., Meazzi S., Gelain M.E., Bonsembiante F., Lauzi S., Paltrinieri S.",56584016900;36895042800;56463768300;57207953240;55911542600;12807802400;55785163400;6508381103;7003879241;,Preliminary investigation on feline coronavirus presence in the reproductive tract of the tom cat as a potential route of viral transmission,2020,Journal of Feline Medicine and Surgery,22,2,,178,185,,,10.1177/1098612X19837114,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85063350003&doi=10.1177%2f1098612X19837114&partnerID=40&md5=04684aa4e999a19764590ffb809f757b,"Department of Veterinary Medicine, University of Milan, Milan, Italy; Central Laboratory, Veterinary Teaching Hospital, University of Milan, Lodi, Italy; Veterinary Reference Centre, Turin, Italy; Department of Comparative Biomedicine and Food Science, University of Padova, Legnaro, Padova, Italy","Stranieri, A., Department of Veterinary Medicine, University of Milan, Milan, Italy, Central Laboratory, Veterinary Teaching Hospital, University of Milan, Lodi, Italy; Probo, M., Department of Veterinary Medicine, University of Milan, Milan, Italy; Pisu, M.C., Veterinary Reference Centre, Turin, Italy; Fioletti, A., Department of Veterinary Medicine, University of Milan, Milan, Italy; Meazzi, S., Department of Veterinary Medicine, University of Milan, Milan, Italy, Central Laboratory, Veterinary Teaching Hospital, University of Milan, Lodi, Italy; Gelain, M.E., Department of Comparative Biomedicine and Food Science, University of Padova, Legnaro, Padova, Italy; Bonsembiante, F., Department of Comparative Biomedicine and Food Science, University of Padova, Legnaro, Padova, Italy; Lauzi, S., Department of Veterinary Medicine, University of Milan, Milan, Italy, Central Laboratory, Veterinary Teaching Hospital, University of Milan, Lodi, Italy; Paltrinieri, S., Department of Veterinary Medicine, University of Milan, Milan, Italy, Central Laboratory, Veterinary Teaching Hospital, University of Milan, Lodi, Italy","Objectives: Feline infectious peritonitis (FIP) is an immune-mediated disease initiated by feline coronavirus (FCoV) infection. To date, the only proven route of transmission is the faecal–oral route, but a possible localisation of FCoV in the reproductive tract of tom cats is of concern, owing to the involvement of the male reproductive tract during FIP and to the presence of reproduction disorders in FCoV-endemic feline catteries. The aim of the study was to investigate the presence and localisation of FCoV in semen and/or in the reproductive tract of tom cats, and its possible association with seroconversion and viraemic phase. Methods: Blood, serum, semen and/or testicle samples were obtained from 46 tom cats. Serology was performed on 38 serum samples, nested reverse transcriptase PCR (nRT-PCR) and reverse transcriptase quantitative PCR (RT-qPCR) were performed on 39 blood samples and on 17 semen samples, and histology, immunohistochemistry and nRT-PCR were performed on 39 testicles. Results: Twenty-four of 38 serum samples were positive on serology. Semen samples were negative on RT-PCR and RT-qPCR for FCoV, while all blood samples were negative at both molecular methods, except for one sample positive at RT-qPCR with a very low viral load. All testicles were negative at immunohistochemistry, while six were positive at nRT-PCR for FCoV. Serology and blood PCR results suggest that the virus was present in the environment, stimulating transient seroconversion. FCoV seems not to localise in the semen of tom cats, making the venereal route as a way of transmission unlikely. Although viral RNA was found in some testicles, it could not be correlated with the viraemic phase. Conclusions and relevance: In the light of these preliminary results, artificial insemination appears safer than natural mating as it eliminates the direct contact between animals, thus diminishing the probability of faecal–oral FCoV transmission. © The Author(s) 2019.",cattery management; Feline coronavirus; feline infectious peritonitis; PCR; prevention; tom cat reproduction,virus RNA; 3' untranslated region; animal experiment; animal tissue; antibody titer; Article; artificial insemination; autopsy; blood sampling; cat; conserved sequence; controlled study; disease transmission; Feline coronavirus; genital system; histopathology; immunofluorescence test; immunohistochemistry; nested polymerase chain reaction; nonhuman; orchiectomy; priority journal; real time reverse transcription polymerase chain reaction; reverse transcription polymerase chain reaction; RNA extraction; semen analysis; seroconversion; serology; urethral catheterization; virus load; virus transmission,"Pedersen, N.C., A review of feline infectious peritonitis virus infection: 1963–2008 (2009) J Feline Med Surg, 11, pp. 225-258; Kipar, A., Bellmann, S., Kremendahl, J., Cellular composition, coronavirus antigen expression and production of specific antibodies in lesions in feline infectious peritonitis (1998) Vet Immunol Immunopathol, 65, pp. 243-257; Paltrinieri, S., Cammarata, M.P., Cammarata, G., Some aspects of humoral and cellular immunity in naturally occuring feline infectious peritonitis (1998) Vet Immunol Immunopathol, 65, pp. 205-220; Pedersen, N.C., An update on feline infectious peritonitis: virology and immunopathogenesis (2014) Vet J, 201, pp. 123-132; Tasker, S., Diagnosis of feline infectious peritonitis: update on evidence supporting available tests (2018) J Feline Med Surg, 20, pp. 228-243; Addie, D.D., Jarrett, O., A study of naturally occurring feline coronavirus infections in kittens (1992) Vet Rec, 130, pp. 133-137; Addie, D.D., Clustering of feline coronaviruses in multicat households (2000) Vet J, 159, pp. 8-9; Addie, D.D., Feline coronavirus infections (2012) Infectious diseases of the dog and cat, pp. 92-108. , Greene C.E., (ed), 4th ed., St Louis, MO, Elsevier, In:, (ed; Kipar, A., Baptiste, K., Barth, A., Natural FCoV infection: cats with FIP exhibit significantly higher viral loads than healthy infected cats (2006) J Feline Med Surg, 8, pp. 69-72; Herrewegh, A.A., de Groot, R.J., Cepica, A., Detection of feline coronavirus RNA in feces, tissues, and body fluids of naturally infected cats by reverse transcriptase PCR (1995) J Clin Microbiol, 33, pp. 684-689; Addie, D.D., Jarrett, O., Use of a reverse-transcriptase polymerase chain reaction for monitoring the shedding of feline coronavirus by healthy cats (2001) Vet Rec, 148, pp. 649-653; Pelican, K.M., Wildt, D.E., Pukazhenthi, B., Ovarian control for assisted reproduction in the domestic cat and wild felids (2006) Theriogenology, 66, pp. 37-48; Jordan, H.L., Howard, J., Sellon, R.K., Transmission of feline immunodeficiency virus in domestic cats via artificial insemination (1996) J Virol, 70, pp. 8224-8228; Dejucq, N., Jegou, B., Viruses in the mammalian male genital tract and their effects on the reproductive system (2001) Microbiol Mol Biol Rev, 65, pp. 208-231; Andrew, S.E., Feline infectious peritonitis (2000) Vet Clin North Am Small Anim Pract, 30, pp. 987-1000; Foster, R.A., Caswell, J.L., Rinkardt, N., Chronic fibrinous and necrotic orchitis in a cat (1996) Can Vet J, 37, pp. 681-982; Sigurðardóttir, O.G., Kolbjørnsen, O., Lutz, H., Orchitis in a cat associated with coronavirus infection (2001) J Comp Pathol, 124, pp. 219-222; Rota, A., Paltrinieri, S., Jussich, S., Priapism in a castrated cat associated with feline infectious peritonitis (2008) J Feline Med Surg, 10, pp. 181-184; Pisu, M.C., Ponzio, P., Rovella, C., Usefulness of an injectable anaesthetic protocol for semen collection through urethral catheterisation in domestic cats (2017) J Feline Med Surg, 19, pp. 1087-1090; Osterhaus, A.D., Horzinek, M.C., Reynolds, D.J., Seroepidemiology of feline infectious peritonitis virus infections using transmissible gastroenteritis virus as antigen (1977) Zentralbl Veterinarmed, 24, pp. 835-841; Das, P.J., Paria, N., Gustafson-Seabury, A., Total RNA isolation from stallion sperm and testis biopsies (2010) Theriogenology, 74, pp. 1099-1106; Gut, M., Leutenegger, C.M., Huder, J.B., One-tube fluorogenic reverse transcription-polymerase chain reaction for the quantitation of feline coronaviruses (1999) J Virol Methods, 77, pp. 37-46; Gunn-Moore, D.A., Gruffydd-Jones, T.J., Harbour, D.A., Detection of feline coronaviruses by culture and reverse transcriptase-polymerase chain reaction of blood samples from healthy cats and cats with clinical feline infectious peritonitis (1998) Vet Microbiol, 62, pp. 193-205; Doenges, S.J., Weber, K., Dorsch, R., Comparison of real-time reverse transcriptase polymerase chain reaction of peripheral blood mononuclear cells, serum and cell-free body cavity effusion for the diagnosis of feline infectious peritonitis (2017) J Feline Med Surg, 19, pp. 344-350; Foley, J.E., Poland, A., Carlson, J., Risk factors for feline infectious peritonitis among cats in multiple-cat environments with endemic feline enteric coronavirus (1997) J Am Vet Med Assoc, 210, pp. 1313-1318; Addie, D.D., Paltrinieri, S., Pedersen, N.C., (2004) J Feline Med Surg, 6, pp. 125-130. , Recommendations from workshops of the second international feline coronavirus/feline infectious peritonitis symposium; Meli, M.L., Burr, P., Decaro, N., Samples with high virus load cause a trend toward lower signal in feline coronavirus antibody tests (2013) J Feline Med Surg, 15, pp. 295-299; Kipar, A., Meli, M.L., Baptiste, K.E., Sites of feline coronavirus persistence in healthy cats (2010) J Gen Virol, 91, pp. 1698-1707; Porter, E., Tasker, S., Day, M.J., Amino acid changes in the spike protein of feline coronavirus correlate with systemic spread of virus from the intestine and not with feline infectious peritonitis (2014) Vet Res, 45; Doenges, S.J., Weber, K., Dorsch, R., Detection of feline coronavirus in cerebrospinal fluid for diagnosis of feline infectious peritonitis in cats with and without neurological signs (2016) J Feline Med Surg, 18, pp. 104-109; Hoffmann, B., Schulz, C., Beer, M., First detection of Schmallenberg virus RNA in bovine semen, Germany (2013) Vet Microbiol, 167, pp. 289-295; Vanbinst, T., Vandenbussche, F., Dernelle, E., A duplex real-time RT-PCR for the detection of bluetongue virus in bovine semen (2010) J Virol Methods, 169, pp. 162-168; Meli, M.L., Kipar, A., Müller, C., High viral loads despite absence of clinical and pathological findings in cats experimentally infected with feline coronavirus (FCoV) type I and in naturally FCoV-infected cats (2004) J Feline Med Surg, 6, pp. 69-81","Stranieri, A.; Department of Veterinary Medicine, University of MilanItaly; email: angelica.stranieri@unimi.it",,SAGE Publications Ltd,1098612X,,,30900940,English,J. Feline Med. Surg.,Article,Final,Open Access,Scopus,2-s2.0-85063350003,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Goh G.K.-M., Keith Dunker A., Foster J.A., Uversky V.N.",24833027800;57215026123;7403380464;7005768480;,Rigidity of the outer shell predicted by a protein intrinsic disorder model sheds light on the COVID-19 (Wuhan-2019-nCoV) infectivity,2020,Biomolecules,10,2,331,,,,1,10.3390/biom10020331,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079706210&doi=10.3390%2fbiom10020331&partnerID=40&md5=508ffd54b371aa82b19bcb0897f382a7,"Goh’s BioComputing, Singapore, 548957, Singapore; Center for Computational Biology, Indiana and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN 46202, United States; Department of Biological Sciences, University of Idaho, Moscow, ID 83844, United States; Institute for Bioinformatics and Evolutionary Studies, University of Idaho, Moscow, ID 83844, United States; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, United States; Institute for Biological Instrumentation of the Russian Academy of Sciences, Federal Research Center ‘Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences’, Moscow region, Pushchino, 142290, Russian Federation","Goh, G.K.-M., Goh’s BioComputing, Singapore, 548957, Singapore; Keith Dunker, A., Center for Computational Biology, Indiana and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN 46202, United States; Foster, J.A., Department of Biological Sciences, University of Idaho, Moscow, ID 83844, United States, Institute for Bioinformatics and Evolutionary Studies, University of Idaho, Moscow, ID 83844, United States; Uversky, V.N., Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, United States, Institute for Biological Instrumentation of the Russian Academy of Sciences, Federal Research Center ‘Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences’, Moscow region, Pushchino, 142290, Russian Federation","The world is currently witnessing an outbreak of a new coronavirus spreading quickly across China and affecting at least 24 other countries. With almost 65,000 infected, a worldwide death toll of at least 1370 (as of 14 February 2020), and with the potential to affect up to two-thirds of the world population, COVID-19 is considered by the World Health Organization (WHO) to be a global health emergency. The speed of spread and infectivity of COVID-19 (also known as Wuhan-2019-nCoV) are dramatically exceeding those of the Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus (SARS-CoV). In fact, since September 2012, the WHO has been notified of 2494 laboratory-confirmed cases of infection with MERS-CoV, whereas the 2002–2003 epidemic of SARS affected 26 countries and resulted in more than 8000 cases. Therefore, although SARS, MERS, and COVID-19 are all the result of coronaviral infections, the causes of the coronaviruses differ dramatically in their transmissibility. It is likely that these differences in infectivity of coronaviruses can be attributed to the differences in the rigidity of their shells which can be evaluated using computational tools for predicting intrinsic disorder predisposition of the corresponding viral proteins. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.",COVID-19; Membrane protein; Nucleocapsid protein; Protein intrinsic disorder; Shell disorder; Transmission; Virulence; Wuhan-2019-nCoV,"M protein; nucleocapsid protein; viral protein; COVID-19; severe acute respiratory syndrome coronavirus 2; viral protein; 2019 novel coronavirus; coronavirus disease 2019; Editorial; epidemic; human; Middle East respiratory syndrome coronavirus; molecular model; nonhuman; prediction; protein intrinsic disorder; protein structure; rigidity; SARS coronavirus; virus infectivity; virus morphology; virus particle; virus transmission; animal; Betacoronavirus; Coronavirus infection; genetics; metabolism; pandemic; physiology; virus entry; virus pneumonia; Animals; Betacoronavirus; Coronavirus Infections; Humans; Pandemics; Pneumonia, Viral; Viral Proteins; Virus Internalization","Goh, G.K., Dunker, A.K., Uversky, V.N., Understanding viral transmission behavior via protein intrinsic disorder prediction: Coronaviruses (2012) J. Pathog., 2012; Goh, G.K., Dunker, A.K., Foster, J.A., Uversky, V.N., HIV vaccine mystery and viral shell disorder (2019) Biomolecules, 9, p. 178; Goh, G.K., (2017) Viral Shapeshifters: Strange Behaviors of HIV and Other Viruses, pp. 978-9811147135. , Simplicity Research Institute: Singapore; Goh, G.K., Dunker, A.K., Uversky, V.N., Nipah shell disorder, modes of infection and virulence (2020) Microb. Pathog., 141; Goh, G.K., Dunker, A.K., Uversky, V.N., Prediction of intrinsic disorder in MERS-CoV/HCoV-EMC supports a high oral-fecal transmission (2013) Plos Curr, 5; (2020) Novel Coronavirus (2019-Ncov), , https://www.who.int/emergencies/diseases/novel-coronavirus-2019; Goh, G.K., Dunker, A.K., Foster, J.A., Uversky, V.N., Shell disorder analysis predicts high resilience of the Wuhan-2019-nCoV outside the body and in the bodily fluids (2020) Microb. Pathog.","Goh, G.K.-M.; Goh’s BioComputingSingapore; email: gohsbiocomputing@yahoo.com",,MDPI AG,2218273X,,,32092911,English,Biomolecules,Editorial,Final,Open Access,Scopus,2-s2.0-85079706210,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Dabaniyasti D., Eksi F., Keskin Ö., Özkars M.Y., Karsligil T., Balci I.",57215503266;23495797100;9274064300;55390300600;6507913096;6602776395;,An investigation into respiratory tract viruses in children with acute lower respiratory tract infection or wheezing,2020,Minerva pediatrica,72,1,,45,54,,,10.23736/S0026-4946.16.04322-X,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080998871&doi=10.23736%2fS0026-4946.16.04322-X&partnerID=40&md5=c4a702bd1841977691391ffcdaf8d3ab,"Department of Medical Microbiology, Faculty of Medicine, Gaziantep UniversityGaziantep, Turkey; Department of Medical Microbiology, Faculty of Medicine, Gaziantep UniversityGaziantep, Turkey; Unit of Pediatric Allergy and Immunology, Faculty of Medicine, Gaziantep UniversityGaziantep, Turkey","Dabaniyasti, D., Department of Medical Microbiology, Faculty of Medicine, Gaziantep UniversityGaziantep, Turkey; Eksi, F., Department of Medical Microbiology, Faculty of Medicine, Gaziantep UniversityGaziantep, Turkey; Keskin, Ö., Unit of Pediatric Allergy and Immunology, Faculty of Medicine, Gaziantep UniversityGaziantep, Turkey; Özkars, M.Y., Unit of Pediatric Allergy and Immunology, Faculty of Medicine, Gaziantep UniversityGaziantep, Turkey; Karsligil, T., Department of Medical Microbiology, Faculty of Medicine, Gaziantep UniversityGaziantep, Turkey; Balci, I., Department of Medical Microbiology, Faculty of Medicine, Gaziantep UniversityGaziantep, Turkey","BACKGROUND: This study aimed to determine the frequencies of respiratory tract viruses in patient (acute lower respiratory tract infection [LRTI] or wheezing) and control (history of asthma without symptoms) groups. METHODS: Using multiplex-polymerase chain reaction (PCR), respiratory tract viruses were investigated in the respiratory tract specimens from patient and control groups followed in the Pediatric Clinic. RESULTS: The viruses detected in the patient and control groups (P=0.013) were as follows, respectively: rhinoviruses A, B, C (25.6% and 36.7%), influenza virus A (21.1% and 0.0%), parainfluenza virus type 1 (7.8% and 1.7%), parainfluenza virus type 4 (5.6% and 0.0%), adenoviruses A, B, C, D, E (4.4% and 1.7%), parainfluenza virus type 3 (4.4% and 1.7%), coronaviruses 229E and NL63 (4.4% and 1.7%), coronavirus OC43 (3.3% and 0.0%), respiratory syncytial virus A (3.3% and 0.0%), parainfluenza virus type 2 (2.2% and 0.0%), influenza virus B (2.2% and 0.0%), and respiratory syncytial virus B (1.1% and 1.7%). No bocavirus, metapneumovirus or enterovirus was found in any specimen. Statistically significant differences in the detection of influenza virus A (P=0.000), the total detection of parainfluenza viruses (P=0.008) and coinfection (P=0.004) were observed between the patient and control groups. CONCLUSIONS: The advantage of our study compared with other studies is the inclusion of not only wheezing patients but also children with asthma without symptom. The higher detection of rhinoviruses both in patient and control groups give rise to thought that these viruses may be responsible for asthma exacerbations and may be related with long duration of virus shedding.",,,,,,NLM (Medline),18271715,,,27854115,English,Minerva Pediatr.,Article,Final,,Scopus,2-s2.0-85080998871,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Arabi Y.M., Fowler R., Hayden F.G.",57211811296;57210312819;7103233446;,Critical care management of adults with community-acquired severe respiratory viral infection,2020,Intensive Care Medicine,46,2,,315,328,,4,10.1007/s00134-020-05943-5,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079717915&doi=10.1007%2fs00134-020-05943-5&partnerID=40&md5=159c4e61041e7abc719e13ed4bb4e565,"College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; Intensive Care Department, King Abdulaziz Medical City, P.O. Box 22490, Riyadh, 11426, Saudi Arabia; Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Canada; Department of Critical Care Medicine, Sunnybrook Hospital, Toronto, Canada; Department of Medicine, Sunnybrook Hospital, Toronto, Canada; Department of Medicine, Division of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, VA, United States","Arabi, Y.M., College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia, Intensive Care Department, King Abdulaziz Medical City, P.O. Box 22490, Riyadh, 11426, Saudi Arabia; Fowler, R., Institute of Health Policy Management and Evaluation, University of Toronto, Toronto, Canada, Department of Critical Care Medicine, Sunnybrook Hospital, Toronto, Canada, Department of Medicine, Sunnybrook Hospital, Toronto, Canada; Hayden, F.G., Department of Medicine, Division of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, VA, United States","With the expanding use of molecular assays, viral pathogens are increasingly recognized among critically ill adult patients with community-acquired severe respiratory illness; studies have detected respiratory viral infections (RVIs) in 17–53% of such patients. In addition, novel pathogens including zoonotic coronaviruses like the agents causing Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS) and the 2019 novel coronavirus (2019 nCoV) are still being identified. Patients with severe RVIs requiring ICU care present typically with hypoxemic respiratory failure. Oseltamivir is the most widely used neuraminidase inhibitor for treatment of influenza; data suggest that early use is associated with reduced mortality in critically ill patients with influenza. At present, there are no antiviral therapies of proven efficacy for other severe RVIs. Several adjunctive pharmacologic interventions have been studied for their immunomodulatory effects, including macrolides, corticosteroids, cyclooxygenase-2 inhibitors, sirolimus, statins, anti-influenza immune plasma, and vitamin C, but none is recommended at present in severe RVIs. Evidence-based supportive care is the mainstay for management of severe respiratory viral infection. Non-invasive ventilation in patients with severe RVI causing acute hypoxemic respiratory failure and pneumonia is associated with a high likelihood of transition to invasive ventilation. Limited existing knowledge highlights the need for data regarding supportive care and adjunctive pharmacologic therapy that is specific for critically ill patients with severe RVI. There is a need for more pragmatic and efficient designs to test different therapeutics both individually and in combination. © 2020, Springer-Verlag GmbH Germany, part of Springer Nature.",Acute respiratory distress syndrome; Antiviral therapy; Antiviral therapy; Coronavirus; Influenza; Neuraminidase inhibitor,"antivirus agent; ascorbic acid; baloxavir; corticosteroid; cyclooxygenase 2 inhibitor; hydroxymethylglutaryl coenzyme A reductase inhibitor; macrolide; rapamycin; sialidase inhibitor; antivirus agent; COVID-19; macrolide; oseltamivir; 2019 novel coronavirus; antiviral therapy; community acquired infection; Coronavirus infection; human; intensive care; Middle East respiratory syndrome; nonhuman; pneumonia; respiratory failure; Review; severe acute respiratory syndrome; viral respiratory tract infection; virus; adult; artificial ventilation; community acquired infection; Coronavirus infection; critical illness; evidence based medicine; influenza; intensive care; intensive care unit; noninvasive ventilation; severe acute respiratory syndrome; severity of illness index; virus pneumonia; Adult; Antiviral Agents; Community-Acquired Infections; Coronavirus Infections; Critical Care; Critical Illness; Evidence-Based Medicine; Humans; Influenza, Human; Intensive Care Units; Macrolides; Noninvasive Ventilation; Oseltamivir; Pneumonia; Pneumonia, Viral; Respiration, Artificial; Severe Acute Respiratory Syndrome; Severity of Illness Index","Karhu, J., Ala-Kokko, T.I., Vuorinen, T., Ohtonen, P., Syrjala, H., Lower respiratory tract virus findings in mechanically ventilated patients with severe community-acquired pneumonia (2014) Clin Infect Dis, 59, pp. 62-70; Hasvold, J., Sjoding, M., Pohl, K., Cooke, C., Hyzy, R.C., The role of human metapneumovirus in the critically ill adult patient (2016) J Crit Care, 31, pp. 233-237; Zumla, A., Memish, Z.A., Maeurer, M., Bates, M., Mwaba, P., Al-Tawfiq, J.A., Denning, D.W., Hui, D.S., Emerging novel and antimicrobial-resistant respiratory tract infections: new drug development and therapeutic options (2014) Lancet Infect Dis, 14, pp. 1136-1149; Hanfelt-Goade, D., Maimon, N., Nimer, A., A phase 2b, randomized, double-blind, placebo-controlled trial of presatovir (GS-5806), a novel oral rsv fusion inhibitor, for the treatment of respiratory syncytial virus (RSV) (2018) Hospitalized Adults American Thoracic Society 2018 International Conference, , San Diego, abstract A4457; Gamino-Arroyo, A.E., Guerrero, M.L., McCarthy, S., Ramirez-Venegas, A., Llamosas-Gallardo, B., Galindo-Fraga, A., Moreno-Espinosa, S., Beigel, J.H., Efficacy and safety of nitazoxanide in addition to standard of care for the treatment of severe acute respiratory illness (2019) Clin Infect Dis, 69, pp. 1903-1911; Beigel, J.H., Nam, H.H., Adams, P.L., Krafft, A., Ince, W.L., El-Kamary, S.S., Sims, A.C., Advances in respiratory virus therapeutics—a meeting report from the 6th isirv Antiviral Group conference (2019) Antiviral Res, 167, pp. 45-67; Muthuri, S.G., Venkatesan, S., Myles, P.R., Leonardi-Bee, J., Al Khuwaitir, T.S., Al Mamun, A., Anovadiya, A.P., Nguyen-Van-Tam, J.S., Effectiveness of neuraminidase inhibitors in reducing mortality in patients admitted to hospital with influenza A H1N1pdm09 virus infection: a meta-analysis of individual participant data (2014) Lancet Respir Med, 2, pp. 395-404; Adisasmito, W., Chan, P.K., Lee, N., Oner, A.F., Gasimov, V., Aghayev, F., Zaman, M., Toovey, S., Effectiveness of antiviral treatment in human influenza A(H5N1) infections: analysis of a Global Patient Registry (2010) J Infect Dis, 202, pp. 1154-1160; Louie, J.K., Yang, S., Acosta, M., Yen, C., Samuel, M.C., Schechter, R., Guevara, H., Uyeki, T.M., Treatment with neuraminidase inhibitors for critically ill patients with influenza A (H1N1)pdm09 (2012) Clin Infect Dis, 55, pp. 1198-1204; Uyeki, T.M., Bernstein, H.H., Bradley, J.S., Englund, J.A., File, T.M., Fry, A.M., Gravenstein, S., Pavia, A.T., Clinical practice guidelines by the infectious diseases society of America: 2018 update on diagnosis, treatment, chemoprophylaxis, and institutional outbreak management of seasonal influenzaa (2019) Clin Infect Dis, 68, pp. 895-902; Welch, S.C., Lam, S.W., Neuner, E.A., Bauer, S.R., Bass, S.N., High-dose versus standard dose oseltamivir for treatment of severe influenza in adult intensive care unit patients (2015) Intensive Care Med, 41, pp. 1365-1366; Lee, N., Hui, D.S., Zuo, Z., Ngai, K.L., Lui, G.C., Wo, S.K., Tam, W.W., Chan, P.K., A prospective intervention study on higher-dose oseltamivir treatment in adults hospitalized with influenza a and B infections (2013) Clin Infect Dis, 57, pp. 1511-1519; Noel, Z.R., Bastin, M.L.T., Montgomery, A.A., Flannery, A.H., Comparison of high-dose versus standard dose oseltamivir in critically ill patients with influenza (2017) J Intensive Care Med, 32, pp. 574-577; Effect of double dose oseltamivir on clinical and virological outcomes in children and adults admitted to hospital with severe influenza: double blind randomised controlled trial (2013) BMJ, 346, p. f3039; Lemaitre, F., Luyt, C.E., Roullet-Renoleau, F., Nieszkowska, A., Zahr, N., Corvol, E., Fernandez, C., Combes, A., Impact of extracorporeal membrane oxygenation and continuous venovenous hemodiafiltration on the pharmacokinetics of oseltamivir carboxylate in critically ill patients with pandemic (H1N1) influenza (2012) Ther Drug Monit, 34, pp. 171-175; Lee, N., Chan, P.K., Wong, C.K., Wong, K.T., Choi, K.W., Joynt, G.M., Lam, P., Hui, D.S., Viral clearance and inflammatory response patterns in adults hospitalized for pandemic 2009 influenza A(H1N1) virus pneumonia (2011) Antivir Ther, 16, pp. 237-247; Behillil, S., May, F., Fourati, S., Luyt, C.E., Chicheportiche, T., Sonneville, R., Tandjaoui-Lambiotte, Y., de Prost, N., Oseltamivir resistance in severe influenza A(H1N1)pdm09 pneumonia and acute respiratory distress syndrome: a French multicenter observational cohort study (2019) Clin Infect Dis; Marty, F.M., Vidal-Puigserver, J., Clark, C., Gupta, S.K., Merino, E., Garot, D., Chapman, M.J., Peppercorn, A.F., Intravenous zanamivir or oral oseltamivir for hospitalised patients with influenza: an international, randomised, double-blind, double-dummy, phase 3 trial (2017) Lancet Respir Med, 5, pp. 135-146; de Jong, M.D., Ison, M.G., Monto, A.S., Metev, H., Clark, C., O’Neil, B., Elder, J., Sheridan, W.P., Evaluation of intravenous peramivir for treatment of influenza in hospitalized patients (2014) Clin Infect Dis, 59, pp. e172-e185; Hayden, F.G., Shindo, N., Influenza virus polymerase inhibitors in clinical development (2019) Curr Opin Infect Diseases, 32 (2), pp. 176-186; Ison, M.G., Portsmouth, S., Yoshida, Y., Shishido, T., Hayden, F., Uehara, T., LB16. 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Hirose, R., Nakaya, T., Naito, Y., Daidoji, T., Bandou, R., Inoue, K., Dohi, O., Itoh, Y., Situations leading to reduced effectiveness of current hand hygiene against infectious mucus from influenza virus-infected patients (2019) mSphere, 4, pp. e00474-e00479; https://www.who.int/influenza/resources/research/en/, Last accessed Jan 4-2020","Arabi, Y.M.; Intensive Care Department, King Abdulaziz Medical City, P.O. Box 22490, Saudi Arabia; email: Arabi@ngha.med.sa",,Springer,3424642,,ICMED,32040667,English,Intensive Care Med.,Review,Final,Open Access,Scopus,2-s2.0-85079717915,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Clasman J.R., Everett R.K., Srinivasan K., Mesecar A.D.",56562966000;57213173938;57213171389;6701470710;,Decoupling deISGylating and deubiquitinating activities of the MERS virus papain-like protease,2020,Antiviral Research,174,,104661,,,,,10.1016/j.antiviral.2019.104661,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077661417&doi=10.1016%2fj.antiviral.2019.104661&partnerID=40&md5=a9bb9888fa2e8d02bcf78a359d458d42,"Department of Biological Sciences, Purdue University, West Lafayette, IN, United States; Department of Biochemistry, Purdue University, West Lafayette, IN, United States; Center for Cancer Research, Purdue University, West Lafayette, IN, United States","Clasman, J.R., Department of Biological Sciences, Purdue University, West Lafayette, IN, United States; Everett, R.K., Department of Biological Sciences, Purdue University, West Lafayette, IN, United States; Srinivasan, K., Department of Biological Sciences, Purdue University, West Lafayette, IN, United States; Mesecar, A.D., Department of Biological Sciences, Purdue University, West Lafayette, IN, United States, Department of Biochemistry, Purdue University, West Lafayette, IN, United States, Center for Cancer Research, Purdue University, West Lafayette, IN, United States","Coronavirus papain-like proteases (PLPs or PLpro), such as the one encoded in the genome of the infectious Middle East Respiratory Syndrome (MERS) virus, have multiple enzymatic activities that promote viral infection. PLpro acts as a protease and processes the large coronavirus polyprotein for virus replication. PLpro also functions as both a deubiquitinating (DUB) and deISGylating (deISG) enzyme and removes ubiquitin (Ub) and interferon-stimulated gene 15 (ISG15) from cellular proteins. Both DUB and deISG activities are implicated in suppressing innate immune responses; however, the precise role of each activity in this process is still unclear due in part to the difficulties in separating each activity. In this study, we determine the first structure of MERS PLpro in complex with the full-length human ISG15 to a resolution of 2.3 Å. This structure and available structures of MERS PLpro-Ub complexes were used as molecular guides to design PLpro mutants that lack either or both DUB/deISG activities. We tested 13 different PLpro mutants for protease, DUB, and deISG activitites using fluorescence-based assays. Results show that we can selectively modulate DUB activity at amino acid positions 1649 and 1653 while mutation of Val1691 or His1652 of PLpro to a positive charged residue completely impairs both DUB/deISG activities. These mutant enzymes will provide new functional tools for delineating the importance of DUB versus deISG activity in virus-infected cells and may serve as potential candidates for attenuating the MERS virus in vivo for modified vaccine design efforts. © 2019",Coronavirus; Crystal structure; deISGylase; ISG15; Papain-like protease; PLpro,amino acid; cell protein; interferon regulatory factor 15; papain like protease; ubiquitin; unclassified drug; virus enzyme; Article; deubiquitination; enzyme active site; enzyme activity; human; innate immunity; Middle East respiratory syndrome coronavirus; mutagenesis; nonhuman; polyacrylamide gel electrophoresis; precipitation; priority journal; site directed mutagenesis,"Afonine, P.V., Grosse-Kunstleve, R.W., Echols, N., Headd, J.J., Moriarty, N.W., Mustyakimov, M., Terwilliger, T.C., Adams, P.D., Towards automated crystallographic structure refinement with phenix.refine (2012) Acta Crystallogr D Biol Crystallogr, 68, pp. 352-367; Akutsu, M., Ye, Y., Virdee, S., Chin, J.W., Komander, D., Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains (2011) Proc. 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Microbiol., 16, pp. 423-439; Ratia, K., Kilianski, A., Baez-Santos, Y.M., Baker, S.C., Mesecar, A., Structural Basis for the Ubiquitin-Linkage Specificity and deISGylating activity of SARS-CoV papain-like protease (2014) PLoS Pathog., 10; Speer, S.D., Li, Z., Buta, S., Payelle-Brogard, B., Qian, L., Vigant, F., Rubino, E., Bogunovic, D., ISG15 deficiency and increased viral resistance in humans but not mice (2016) Nat. Commun., 7, p. 11496; Studier, F.W., Protein production by auto-induction in high density shaking cultures (2005) Protein Expr. Purif., 41, pp. 207-234; van Kasteren, P.B., Bailey-Elkin, B.A., James, T.W., Ninaber, D.K., Beugeling, C., Khajehpour, M., Snijder, E.J., Kikkert, M., Deubiquitinase function of arterivirus papain-like protease 2 suppresses the innate immune response in infected host cells (2013) Proc. Natl. Acad. Sci. U. S. A., 110. , E838-847; WHO, Middle East Respiratory Syndrome (MERS-CoV) (2018); Wilkinson, K.D., Gan-Erdene, T., Kolli, N., Derivitization of the C-terminus of ubiquitin and ubiquitin-like proteins using intein chemistry: methods and uses (2005) Methods Enzymol., 399, pp. 37-51; Zhang, X., Bogunovic, D., Payelle-Brogard, B., Francois-Newton, V., Speer, S.D., Yuan, C., Volpi, S., Pellegrini, S., Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation (2015) Nature, 517, pp. 89-93; Zhao, C., Collins, M.N., Hsiang, T.Y., Krug, R.M., Interferon-induced ISG15 pathway: an ongoing virus-host battle (2013) Trends Microbiol., 21, pp. 181-186; Zheng, L., Baumann, U., Reymond, J.L., An efficient one-step site-directed and site-saturation mutagenesis protocol (2004) Nucleic Acids Res., 32, p. e115","Mesecar, A.D.; Department of Biological Sciences, Purdue UniversityUnited States; email: amesecar@purdue.edu",,Elsevier B.V.,1663542,,ARSRD,31765674,English,Antiviral Res.,Article,Final,Open Access,Scopus,2-s2.0-85077661417,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Casey G.,18343740800;,Coronavirus-A developing outbreak,2020,Kai Tiaki Nursing New Zealand,26,1,,26,,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081650925&partnerID=40&md5=9dc933e15b1d280651b70fa624cd3786,,"Casey, G.",[No abstract available],,,"A call to think more creatively Kai Tiaki Nursing New Zealand, 25 (9), p. 32. , 2019, October; Durie, M., (1994) Whaiora: Maori Health Development., , Auckland: Oxford University Press; Argyris, C., Schon, D.A., (1996) Organizational Learning II: Theory, Method and Practice, , Reading, MA: Addison-Wesley; Walker, L., Walking in two worlds (2015) Kai Tiaki Nursing New Zealand, 21 (5), pp. 34-35; (2007) Competencies for Registered Nurses, , www.nursingcouncil.org.nz, Nursing Council of New Zealand. . 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(2014) Nursing Praxis in New Zealand, 30 (3), pp. 2-4; Hunter, K., The significant cultural value of our maori nursing workforce (2019) Nursing Praxis in New Zealand, 35 (3), pp. 4-6. , doi:10.36951/NgPxNZ.2019.009; Simon, V., Characterising maori nursing practice (2006) Contemporary Nurse, 22 (2), pp. 203-213; Argyris, C., Schon, D.A., (1996) Organizational Learning II: Theory, Method and Practice, , Reading, MA: Addison-Wesley",,,New Zealand Nurses Organisation,11732032,,,,English,Kai Tiaki Nurs. New Zealand,Note,Final,,Scopus,2-s2.0-85081650925,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Descatha A.,6506111339;,"Coronavirus, occupational health safety [Coronavirus et professionnels de santé au travail]",2020,Archives des Maladies Professionnelles et de l'Environnement,81,1,,1,2,,,10.1016/j.admp.2020.02.002,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081304445&doi=10.1016%2fj.admp.2020.02.002&partnerID=40&md5=1e1fe1fd45915851b9bb93ce6ddf0629,"Univ Angers, CHU Angers, Univ Rennes, Inserm, EHESP, Irset, UMR_S 1085, Angers, France; Archives des maladies professionnelles et de l'environnement, Elsevier Masson, 65, rue Camille-Desmoulins, Issy-les-Moulineaux Cedex, 92442, France","Descatha, A., Univ Angers, CHU Angers, Univ Rennes, Inserm, EHESP, Irset, UMR_S 1085, Angers, France, Archives des maladies professionnelles et de l'environnement, Elsevier Masson, 65, rue Camille-Desmoulins, Issy-les-Moulineaux Cedex, 92442, France",[No abstract available],,,,"Descatha, A.; Equipe Ester, Faculté de santé-Univ Angers, 28 rue Amsler, France; email: archives.mpe@gmail.com",,Elsevier Masson SAS,17758785,,,,English; French,Arch. Mal. Prof. Environ.,Editorial,Final,Open Access,Scopus,2-s2.0-85081304445,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Al-Mandhari A., Samhouri D., Abubakar A., Brennan R.",57214824842;55777854700;54940901400;57215532038;,Coronavirus disease 2019 outbreak: Preparedness and readiness of countries in the eastern mediterranean region,2020,Eastern Mediterranean Health Journal,26,2,,136,137,,,10.26719/2020.26.2.136,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081092802&doi=10.26719%2f2020.26.2.136&partnerID=40&md5=18c52216cea17307b9bf89f31296b378,"World Health Organization Regional Office for the Eastern Mediterranean, Cairo, Egypt; Emergency Preparedness and International Health Regulations, World Health Organization Regional Office for the Eastern Mediterranean, Cairo, Egypt; Infectious Hazard Preparedness Unit, World Health Organization Regional Office for the Eastern Mediterranean, Cairo, Egypt","Al-Mandhari, A., World Health Organization Regional Office for the Eastern Mediterranean, Cairo, Egypt; Samhouri, D., Emergency Preparedness and International Health Regulations, World Health Organization Regional Office for the Eastern Mediterranean, Cairo, Egypt; Abubakar, A., Infectious Hazard Preparedness Unit, World Health Organization Regional Office for the Eastern Mediterranean, Cairo, Egypt; Brennan, R., World Health Organization Regional Office for the Eastern Mediterranean, Cairo, Egypt",[No abstract available],,"oseltamivir; COVID-19; severe acute respiratory syndrome coronavirus 2; 2019 novel coronavirus; acute respiratory tract disease; bat; coronavirus disease 2019; coughing; disease surveillance; disease transmission; Editorial; fever; geographic distribution; health care personnel; human; Middle East respiratory syndrome; public health; public health service; sea food; severe acute respiratory syndrome; Southern Europe; virus detection; animal; Betacoronavirus; Coronavirus infection; epidemic; infection control; pandemic; procedures; public health service; Southern Europe; virus pneumonia; World Health Organization; Animals; Betacoronavirus; Coronavirus Infections; Disease Outbreaks; Humans; Infection Control; Mediterranean Region; Pandemics; Pneumonia, Viral; Public Health Practice; World Health Organization","(2020) Novel Coronavirus (2019-Ncov), , https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200121-sitrep-1-2019-ncov.pdf?sfvrsn, Situation report 1. Geneva: World Health Organization; Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Early transmission dynamics in Wuhan, China, of novel coronavirus–infect-ed pneumonia (2020) New Engl J Med, 29, pp. 1-9. , Jan; (2020) WHO Director-General’s Statement on IHR Emergency Committee on Novel Coronavirus (2019-Ncov), , https://www.who.int/dg/speeches/detail/who-director-general-s-state-ment-on-ihr-emergency-committee-on-novel-coronavirus-2019-ncov, Geneva: World Health Organization; (2020) Novel Coronavirus (2019-Ncov). Situation Report 19. Geneva: World Health Organization, , https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200215-si-trep-26-covid-19.pdf?sfvrsn=a4cc6787_22, 2020 Geneva: World Health Organization; Wongcha-Um, P., Cocktail of flu, HIV drugs appears to help fight coronavirus: Thai Doctors (2020) Thomson Reuters, , https://www.reuters.com/article/us-china-health-thailand/cocktail-of-flu-hiv-drugs-appears-to-help-fight-coronavirus-thai-doctors-idUSKBN1ZW0GQ; Zhou, P., Yang, X., Wang, X., Hu, B., Zhang, L., Zhang, W., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature, , 3 Feb., Epub ahead of print; Lu, R., Zhao, X., Li, J., Niu, P., Yang, B., Wu, H., Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding (2020) The Lancet, 29, pp. 1-10. , Jan; Mahjour, J., Alwan, A., Emerging infections and global health security: The case (again) for strengthening all-hazards preparedness and response under IHR-2005 (2014) East Mediterr Health J, 20 (10), pp. 587-588. , http://www.emro.who.int/emhj-vol-20-2014/vol-ume-20-issue-10/editorial-emerging-infections-and-global-health-security-the-case-again-for-strengthening-all-hazards-prepar-edness-and-response-under-ihr-2005.html; Samhouri, D., Ijaz, K., Rashidian, A., Chungong, S., Flahault, A., Babich, S.M., Analysis of Joint External Evaluations in the Eastern Mediterranean Region (2018) East Mediterr Health J, 24 (5), pp. 477-487. , http://applications.emro.who.int/emhj/v24/05/EMHJ_2018_24_05_477_487.pdf; Samhouri, D., Ijaz, K., Thieren, M., Flahault, A., Babich, S.M., Jafari, H., WHO Joint External evaluations in the Eastern Mediterranean Region, 2016–17 (2018) Health Secur., 16 (1), pp. 69-76. , https://www.ncbi.nlm.nih.gov/pubmed/29406822; Enhancing influenza surveillance in the Eastern Mediterranean Region: Eastern Mediterranean Acute Respiratory Infection Surveillance (EMARIS) network – third inter-country meeting (2016) East Mediterr Health J, 22 (7), pp. 560-561; (2020) Statement on the Second Meeting of the International Health Regulations (2005) Emergency Committee regarding the Outbreak of Novel Coronavirus (2019-Ncov), , https://www.who.int/news-room/detail/30-01-2020-statement-on-the-second-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-outbreak-of-novel-coronavirus-(2019-ncov), Geneva: World Health Organization","Samhouri, D.; Emergency Preparedness and International Health Regulations, World Health Organization Regional Office for the Eastern MediterraneanEgypt; email: samhourid@who.int",,World Health Organization,10203397,,EMHJA,32141588,English,East. Mediterr. Health J.,Editorial,Final,Open Access,Scopus,2-s2.0-85081092802,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Colson P., La Scola B., Esteves-Vieira V., Ninove L., Zandotti C., Jimeno M.-T., Gazin C., Bedotto M., Filosa V., Giraud-Gatineau A., Chaudet H., Brouqui P., Lagier J.-C., Raoult D.",7102090499;7007051194;57215522822;26656109700;7004678337;7003949924;35773193600;35483166900;57215524191;57215524091;35268164000;7005522769;24366829400;57208853524;,Letter to the editor: Plenty of coronaviruses but no SARS-CoV-2,2020,Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin,25,8,,,,,,10.2807/1560-7917.ES.2020.25.8.2000171,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081041920&doi=10.2807%2f1560-7917.ES.2020.25.8.2000171&partnerID=40&md5=b3d0a623c9ab9db4120c69afceb0d80f,"Aix-Marseille University, Institut de Recherche pour le Développement (IRD), Assistance Publique - Hôpitaux de Marseille (AP-HM), Microbes Evolution Phylogeny and Infections (MEPHI), France; Institut Hospitalo-Universitaire (IHU) Méditerranée Infection, Marseille, France; Unité des Virus Emergents (UVE), Aix-Marseille University, IRD 190, Inserm 1207, IHU Méditerranée Infection, Marseille, France; Service de l'Information Médicale, Hôpital de la Timone, Marseille, France; French Armed Forces Center for Epidemiology and Public Health (CESPA), Service de Santé des Armées (SSA), Marseille, France; Aix-Marseille University, Institut de Recherche pour le Développement (IRD), Assistance Publique - Hôpitaux de Marseille (AP-HM), Vecteurs - Infections Tropicales et Méditerranéennes (VITROME), Marseille, France","Colson, P., Aix-Marseille University, Institut de Recherche pour le Développement (IRD), Assistance Publique - Hôpitaux de Marseille (AP-HM), Microbes Evolution Phylogeny and Infections (MEPHI), France, Institut Hospitalo-Universitaire (IHU) Méditerranée Infection, Marseille, France; La Scola, B., Aix-Marseille University, Institut de Recherche pour le Développement (IRD), Assistance Publique - Hôpitaux de Marseille (AP-HM), Microbes Evolution Phylogeny and Infections (MEPHI), France, Institut Hospitalo-Universitaire (IHU) Méditerranée Infection, Marseille, France; Esteves-Vieira, V., Institut Hospitalo-Universitaire (IHU) Méditerranée Infection, Marseille, France; Ninove, L., Institut Hospitalo-Universitaire (IHU) Méditerranée Infection, Marseille, France, Unité des Virus Emergents (UVE), Aix-Marseille University, IRD 190, Inserm 1207, IHU Méditerranée Infection, Marseille, France; Zandotti, C., Institut Hospitalo-Universitaire (IHU) Méditerranée Infection, Marseille, France, Unité des Virus Emergents (UVE), Aix-Marseille University, IRD 190, Inserm 1207, IHU Méditerranée Infection, Marseille, France; Jimeno, M.-T., Service de l'Information Médicale, Hôpital de la Timone, Marseille, France; Gazin, C., Institut Hospitalo-Universitaire (IHU) Méditerranée Infection, Marseille, France; Bedotto, M., Institut Hospitalo-Universitaire (IHU) Méditerranée Infection, Marseille, France; Filosa, V., Institut Hospitalo-Universitaire (IHU) Méditerranée Infection, Marseille, France; Giraud-Gatineau, A., Institut Hospitalo-Universitaire (IHU) Méditerranée Infection, Marseille, France, French Armed Forces Center for Epidemiology and Public Health (CESPA), Service de Santé des Armées (SSA), Marseille, France, Aix-Marseille University, Institut de Recherche pour le Développement (IRD), Assistance Publique - Hôpitaux de Marseille (AP-HM), Vecteurs - Infections Tropicales et Méditerranéennes (VITROME), Marseille, France; Chaudet, H., Institut Hospitalo-Universitaire (IHU) Méditerranée Infection, Marseille, France, French Armed Forces Center for Epidemiology and Public Health (CESPA), Service de Santé des Armées (SSA), Marseille, France, Aix-Marseille University, Institut de Recherche pour le Développement (IRD), Assistance Publique - Hôpitaux de Marseille (AP-HM), Vecteurs - Infections Tropicales et Méditerranéennes (VITROME), Marseille, France; Brouqui, P., Aix-Marseille University, Institut de Recherche pour le Développement (IRD), Assistance Publique - Hôpitaux de Marseille (AP-HM), Microbes Evolution Phylogeny and Infections (MEPHI), France, Institut Hospitalo-Universitaire (IHU) Méditerranée Infection, Marseille, France; Lagier, J.-C., Aix-Marseille University, Institut de Recherche pour le Développement (IRD), Assistance Publique - Hôpitaux de Marseille (AP-HM), Microbes Evolution Phylogeny and Infections (MEPHI), France, Institut Hospitalo-Universitaire (IHU) Méditerranée Infection, Marseille, France; Raoult, D., Aix-Marseille University, Institut de Recherche pour le Développement (IRD), Assistance Publique - Hôpitaux de Marseille (AP-HM), Microbes Evolution Phylogeny and Infections (MEPHI), France, Institut Hospitalo-Universitaire (IHU) Méditerranée Infection, Marseille, France",[No abstract available],Coronavirus; France; respiratory infections; SARS-CoV-2,"COVID-19; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; classification; Coronavirinae; Coronavirus infection; genetics; human; mortality; polymerase chain reaction; SARS coronavirus; virus pneumonia; Betacoronavirus; Coronavirus; Coronavirus Infections; Humans; Pneumonia, Viral; Polymerase Chain Reaction; SARS Virus",,,,NLM (Medline),15607917,,,32127122,English,Euro Surveill.,Article,Final,Open Access,Scopus,2-s2.0-85081041920,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Reusken C.B., Haagmans B., Meijer A., Corman V.M., Papa A., Charrel R., Drosten C., Koopmans M.",6602366009;6701371301;57061899200;34876424800;7103044603;57203046891;7003813990;7006736989;,Authors' response: Plenty of coronaviruses but no SARS-CoV-2,2020,Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin,25,8,,,,,,10.2807/1560-7917.ES.2020.25.8.2000197,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081021532&doi=10.2807%2f1560-7917.ES.2020.25.8.2000197&partnerID=40&md5=f3d9b29687ee759ccad9758b84e49f00,"Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands; Viroscience department, Erasmus MC, Rotterdam, Netherlands; Charité - Universitätsmedizin Berlin Institute of Virology, Germany and German Centre for Infection Research (DZIF)Berlin, Germany; Department of Microbiology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece; Unité des Virus Emergents (Aix-Marseille Univ-IRD 190-Inserm 1207-IHU Méditerranée Infection), Marseille, France","Reusken, C.B., Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands; Haagmans, B., Viroscience department, Erasmus MC, Rotterdam, Netherlands; Meijer, A., Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands; Corman, V.M., Charité - Universitätsmedizin Berlin Institute of Virology, Germany and German Centre for Infection Research (DZIF)Berlin, Germany; Papa, A., Department of Microbiology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece; Charrel, R., Unité des Virus Emergents (Aix-Marseille Univ-IRD 190-Inserm 1207-IHU Méditerranée Infection), Marseille, France; Drosten, C., Charité - Universitätsmedizin Berlin Institute of Virology, Germany and German Centre for Infection Research (DZIF)Berlin, Germany; Koopmans, M., Viroscience department, Erasmus MC, Rotterdam, Netherlands",[No abstract available],Coronavirus; respiratory infections; SARS-CoV-2,Middle East respiratory syndrome coronavirus; phylogeny; SARS coronavirus; Middle East Respiratory Syndrome Coronavirus; Phylogeny; SARS Virus,,,,NLM (Medline),15607917,,,32127125,English,Euro Surveill.,Note,Final,Open Access,Scopus,2-s2.0-85081021532,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Cowling B.J., Leung G.M.",8644765500;7007159841;,Epidemiological research priorities for public health control of the ongoing global novel coronavirus (2019-nCoV) outbreak,2020,Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin,25,6,,,,,2,10.2807/1560-7917.ES.2020.25.6.2000110,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080843714&doi=10.2807%2f1560-7917.ES.2020.25.6.2000110&partnerID=40&md5=99c7759781552347254a262deba52635,"WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong Special Administrative Region, China","Cowling, B.J., WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong Special Administrative Region, China; Leung, G.M., WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong Special Administrative Region, China",[No abstract available],"2019-nCoV, coronavirus, emerging infections, response, air-borne infections; emerging or re-emerging diseases; viral infections","COVID-19; Coronavirus infection; disease predisposition; epidemic; human; immunity; infection control; public health; research; severity of illness index; virus pneumonia; Coronavirus Infections; Disease Outbreaks; Disease Susceptibility; Epidemiologic Studies; Humans; Immunity; Infection Control; Pneumonia, Viral; Public Health; Research; Severity of Illness Index",,,,NLM (Medline),15607917,,,32046814,English,Euro Surveill.,Article,Final,Open Access,Scopus,2-s2.0-85080843714,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Lee A.,24829388800;,Wuhan novel coronavirus (COVID-19): why global control is challenging?,2020,Public Health,179,,,A1,A2,,,10.1016/j.puhe.2020.02.001,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079899881&doi=10.1016%2fj.puhe.2020.02.001&partnerID=40&md5=9c98105102a58d6ddc36cbf098c22d7e,"Global Public Health, ScHARR, The University of SheffieldEngland, United Kingdom","Lee, A., Global Public Health, ScHARR, The University of SheffieldEngland, United Kingdom",[No abstract available],,"2019 novel coronavirus; Australia; Canada; Coronavirinae; coronavirus disease 2019; Coronavirus infection; disease control; disease surveillance; disease transmission; Editorial; exposure; Finland; health care system; human; infection risk; Japan; low income country; middle income country; nonhuman; patient monitoring; pneumonia; South America; United Kingdom; United States; Viet Nam; virus isolation; virus transmission; workforce; World Health Organization; Betacoronavirus; China; contact examination; Coronavirinae; Coronavirus infection; epidemic; global health; infection control; isolation and purification; pneumonia; virus pneumonia; Coronavirus; COVID-19; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; China; Contact Tracing; Coronavirus; Coronavirus Infections; Disease Outbreaks; Global Health; Humans; Infection Control; Pneumonia; Pneumonia, Viral","Novel coronavirus(2019-nCoV) situation report - 1 (website) (2020), https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200121-sitrep-1-2019-ncov.pdf?sfvrsn=20a99c10_4, WHO 21 January 2020. Available at: Accessed 30/1/20; Novel coronavirus(2019-nCoV) situation report - 11 (website) (2020), https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200131-sitrep-11-ncov.pdf?sfvrsn=de7c0f7_4, WHO 31 January 2020. Available at: Accessed 3/2/20; Shen, Z., Ning, F., Zhou, W., He, X., Lin, C., Chin, D.P., Zhu, Z., Schuchat, A., Superspreading SARS events, Beijing, 2003 (2004) Emerg Infect Dis, 10 (2), p. 256; Kucharski, A.J., Althaus, C., The role of superspreading in Middle East respiratory syndrome coronavirus (MERS-CoV) transmission (2015) Euro Surveill, 20 (25). , pii-21167; John, R.K., King, A., De Jong, D., Bodie-Collins, M., Squires, S.G., Tam, T.W., Border screening for SARS (2005) Emerg Infect Dis, 11 (1), p. 6; Selvey, L.A., Antão, C., Hall, R., Evaluation of border entry screening for infectious diseases in humans (2015) Emerg Infect Dis, 21 (2), p. 197; Olsen, S.J., Chang, H.L., Cheung, T.Y., Tang, A.F., Fisk, T.L., Ooi, S.P., Kuo, H.W., Hsu, K.H., Transmission of the severe acute respiratory syndrome on aircraft (2003) N Engl J Med, 349 (25), pp. 2416-2422; Hui, D.S., Azhar, E.I., Kim, Y.J., Memish, Z.A., Oh, M.D., Zumla, A., Middle East respiratory syndrome coronavirus: risk factors and determinants of primary, household, and nosocomial transmission (2018) Lancet Infect Dis, 18 (8), pp. e217-e227; May, L., Chretien, J.P., Pavlin, J.A., Beyond traditional surveillance: applying syndromic surveillance to developing settings–opportunities and challenges (2009) BMC Publ Health, 9 (1), p. 242; Morse, S.S., Global infectious disease surveillance and health intelligence (2007) Health Aff, 26 (4), pp. 1069-1077; Sahal, N., Reintjes, R., Aro, A.R., Communicable diseases surveillance lessons learned from developed and developing countries: literature review (2009) Scand J Publ Health, 37 (2), pp. 187-200; Masters, R., Anwar, E., Collins, B., Cookson, R., Capewell, S., Return on investment of public health in- terventions: a systematic review (2017) J Epidemiol Community Health, 71, pp. 827-834; Read, J.M., Bridgen, J.R., Cummings, D.A., Ho, A., Jewell, C.P., Novel coronavirus 2019-nCoV: early estimation of epidemiological parameters and epidemic predictions (2020) medRxiv; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Cheng, Z., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506; Mills, C.E., Robins, J.M., Lipsitch, M., Transmissibility of 1918 pandemic influenza (2004) Nature, 432 (7019), pp. 904-906",,,Elsevier B.V.,333506,,PUHEA,32111295,English,Public Health,Editorial,Final,Open Access,Scopus,2-s2.0-85079899881,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Xiao C.,57215086634;,A novel approach of consultation on 2019 novel coronavirus (COVID-19)-related psychological and mental problems: Structured letter therapy,2020,Psychiatry Investigation,17,2,,175,176,,,10.30773/pi.2020.0047,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079871984&doi=10.30773%2fpi.2020.0047&partnerID=40&md5=15e555692f5404171016eb6b5a0287ec,"The National Clinical Research Center for Mental Disorder & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China; Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China","Xiao, C., The National Clinical Research Center for Mental Disorder & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, China, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China",[No abstract available],,2019 novel coronavirus; art therapy; China; consultation; coronavirus disease 2019; counselor; emergency; fear; human; interpersonal communication; letter; Letter; letter therapy; mental disease; patient counseling; patient worry; psychiatrist; quarantine,"Real-time situation of 2019 novel coronavirus in China (2020) Dxy.Cn, , https://ncov.dxy.cn/ncovh5/view/pneumonia, Accessed Feb 3","Xiao, C.; The National Clinical Research Center for Mental Disorder & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical University, 5 Ankang Hutong, China; email: springwindxiao@163.com",,Korean Neuropsychiatric Association,17383684,,,,English,Psychiatry Investig.,Letter,Final,Open Access,Scopus,2-s2.0-85079871984,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Park S.-C., Park Y.C.",41762329500;57212508466;,Mental health care measures in response to the 2019 novel coronavirus outbreak in Korea,2020,Psychiatry Investigation,17,2,,85,86,,,10.30773/pi.2020.0058,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079840094&doi=10.30773%2fpi.2020.0058&partnerID=40&md5=696273195236f0515246695e02b3c42e,"Department of Psychiatry, Inje University Haeundae Paik Hospital, Busan, South Korea; Department of Neuropsychiatry, Hanyang University Guri Hospital, Guri, South Korea","Park, S.-C., Department of Psychiatry, Inje University Haeundae Paik Hospital, Busan, South Korea; Park, Y.C., Department of Neuropsychiatry, Hanyang University Guri Hospital, Guri, South Korea",[No abstract available],,2019 novel coronavirus; anxiety; coronavirus disease 2019; disease exacerbation; distress syndrome; Editorial; health care personnel; hemodialysis; human; insomnia; Middle East respiratory syndrome; pneumonia; practice guideline; psychiatric treatment; upper respiratory tract infection,"Yoo, J.H., The fight against the 2019-nCoV outbreak: An arduous march has just begun (2020) J Korean Med Sci, 35; Kim, J.Y., Choe, P.Y., Oh, Y., Oh, K.J., Kim, J., Park, S.J., The first case of 2019 novel coronavirus pneumonia imported into Korea from Wuhan, China: Implication for infection prevention and control measures (2020) J Korean Med Sci, 35; Wu, J.T., Leung, K., Leung, G.M., Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: A modeling study (2020) Lancet, , Epub ahead of print; Yoo, J.H., Hong, S.T., The outbreak cases with the novel coronavirus suggest upgraded quarantine and isolation in Korea (2020) J Korean Med Sci, 35; Lee, S.M., Kang, W.S., Cho, A.R., Kim, T., Park, J.K., Psychological impact of the 2015 MERS outbreak on hospital workers and quarantined hemodial-ysis patients (2018) Compr Psychiatry, 87, pp. 123-127; Son, H., Lee, W.J., Kim, H.S., Lee, K.S., You, M., Examination of hospital work-ers’ emotional responses to an infectious disease outbreak: Lessons from the 205 MERS Co-V outbreak in South Korea (2019) Disaster Med Public Health Prep, 13, pp. 504-510; Jeng, H., Yim, H.W., Song, Y.J., Ki, M., Min, J.A., Cho, J., Mental health status of people isolated due to Middle East respiratory syndrome (2016) Epidemiol Health, 38; Xiang, Y.T., Yang, Y., Li, W., Zhang, L., Zhang, Q., Cheung, T., Timely mental health care for the 2019 novel coronavirus outbreak is urgently needed (2020) Lancet Psychiatry, , Epub ahead of print; Psychological Support Guidance against Infectious Disease Distress, , https://nct.go.kr/servi-ceCenter/noticeList.do, Accessed February 7, 2020; Park, Y.C., Contribution and responsibility of psychiatric researchers to establish managing system for psychiatric trauma (2017) J Korean Med Sci, 32, pp. 1054-1055","Park, Y.C.; Department of Neuropsychiatry, Hanyang University Guri Hospital, 153 Gyeong-chun-ro, South Korea; email: hypyc@hanyang.ac.kr",,Korean Neuropsychiatric Association,17383684,,,,English,Psychiatry Investig.,Editorial,Final,Open Access,Scopus,2-s2.0-85079840094,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Ng L.F.P., Hiscox J.A.",7201477950;7004565877;,Coronaviruses in animals and humans,2020,The BMJ,368,, m634,,,,,10.1136/bmj.m634,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079830560&doi=10.1136%2fbmj.m634&partnerID=40&md5=bbc30de3a986ed98cb6f004e81666bb2,"Institute for Infection and Global Health, University of Liverpool, United Kingdom; Health Protection Research Unit in Emerging and Zoonotic Infections, Liverpool, United Kingdom; Singapore Immunology Network, A-STAR, Singapore","Ng, L.F.P., Institute for Infection and Global Health, University of Liverpool, United Kingdom, Health Protection Research Unit in Emerging and Zoonotic Infections, Liverpool, United Kingdom, Singapore Immunology Network, A-STAR, Singapore; Hiscox, J.A., Institute for Infection and Global Health, University of Liverpool, United Kingdom, Health Protection Research Unit in Emerging and Zoonotic Infections, Liverpool, United Kingdom, Singapore Immunology Network, A-STAR, Singapore",[No abstract available],,antivirus agent; cell protein; coronavirus spike glycoprotein; DNA vaccine; virus vaccine; 2019 novel coronavirus; Africa; antiviral resistance; Avian infectious bronchitis virus; biological model; case fatality rate; chicken; comorbidity; Coronavirinae; disease severity; Ebola hemorrhagic fever; Editorial; epidemic; gastrointestinal disease; gene sequence; genetic analysis; human; Human respiratory syncytial virus; immunity; incidence; infection control; infection risk; inflammation; Influenza virus; kidney disease; Klebsiella pneumoniae; Middle East respiratory syndrome; mixed infection; mortality rate; nonhuman; oviduct; poultry; priority journal; prognosis; respiratory tract disease; SARS coronavirus; Saudi Arabia; serology; therapy effect; treatment outcome; virus load; virus replication; virus strain; animal; Coronavirinae; Coronavirus infection; disease carrier; drug development; epidemic; pathogenicity; veterinary medicine; Animals; Antiviral Agents; Coinfection; Comorbidity; Coronavirus; Coronavirus Infections; Disease Outbreaks; Disease Reservoirs; Drug Development; Humans; Prognosis; Viral Vaccines,"Falzarano, D., De Wit, E., Rasmussen, A.L., Treatment with interferon-2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques (2013) Nat Med, 19, pp. 1313-1317; Arabi, Y.M., Shalhoub, S., Mandourah, Y., Ribavirin and interferon therapy for critically ill patients with Middle East respiratory syndrome: A multicenter observational study (2019) Clin Infect Dis, p. ciz544; Modjarrad, K., Roberts, C.C., Mills, K.T., Safety and immunogenicity of an anti-Middle East respiratory syndrome coronavirus DNA vaccine: A phase 1, open-label, single-arm, dose-escalation trial (2019) Lancet Infect Dis, 19, pp. 1013-1022; Timothy, J.W.S., Hall, Y., Akoi-Boré, J., Early transmission and case fatality of Ebola virus at the index site of the 2013-16 west African Ebola outbreak: A cross-sectional seroprevalence survey (2019) Lancet Infect Dis, 19, pp. 429-438; Carroll, M.W., Haldenby, S., Rickett, N.Y., Deep sequencing of RNA from blood and oral swab samples reveals the presence of nucleic acid from a number of pathogens in patients with acute Ebola virus disease and is consistent with bacterial translocation across the gut (2017) MSphere, 2, pp. e00325-e00417; Ng, L.F., Hibberd, M.L., Ooi, E.E., A human in vitro model system for investigating genome-wide host responses to SARS coronavirus infection (2004) BMC Infect Dis, 4, p. 34; Liu, X., Speranza, E., Muñoz-Fontela, C., Transcriptomic signatures differentiate survival from fatal outcomes in humans infected with Ebola virus (2017) Genome Biol, 18, p. 4; Kafetzopoulou, L.E., Pullan, S.T., Lemey, P., Metagenomic sequencing at the epicenter of the Nigeria 2018 Lassa fever outbreak (2019) Science, 363, pp. 74-77; Carroll, M.W., Retrospective versus real-time Ebola virus sequencing (2019) Lancet Infect Dis, 19, pp. 567-568","Hiscox, J.A.; Institute for Infection and Global Health, University of LiverpoolUnited Kingdom; email: Julian.Hiscox@liverpool.ac.uk",,BMJ Publishing Group,9598146,,BMJOA,32075782,English,BMJ,Editorial,Final,Open Access,Scopus,2-s2.0-85079830560,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Mallapaty S.,55683091500;,Scientists fear coronavirus spread in countries least able to contain it,2020,Nature,578,7795,,348,,,,10.1038/d41586-020-00405-w,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079792295&doi=10.1038%2fd41586-020-00405-w&partnerID=40&md5=4c8122c64064ab802b082aa9f71d96da,,"Mallapaty, S.",[No abstract available],Epidemiology; Events; Infection; Virology,,,,,NLM (Medline),14764687,,,32071443,English,Nature,Note,Final,Open Access,Scopus,2-s2.0-85079792295,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, [No author name available],[No author id available],"Coronavirus name, animal-research data and a Solar System snowman",2020,Nature,578,7795,,342,343,,,10.1038/d41586-020-00453-2,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079775976&doi=10.1038%2fd41586-020-00453-2&partnerID=40&md5=f83d86bcf6ad33237165cfada15edf6f,,,[No abstract available],"Asteroids, comets and Kuiper belt; Politics; Research data; Virology",,,,,NLM (Medline),14764687,,,32076224,English,Nature,Note,Final,Open Access,Scopus,2-s2.0-85079775976,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Shu L.,57212606483;,Avoid stigmatizing names for 2019 novel coronavirus,2020,Nature,578,7795,,363,,,,10.1038/d41586-020-00458-x,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079757744&doi=10.1038%2fd41586-020-00458-x&partnerID=40&md5=4e14c8dac450c02ded2866dcb6f89538,,"Shu, L.",[No abstract available],Media; Virology,,,,,NLM (Medline),14764687,,,32071450,English,Nature,Note,Final,Open Access,Scopus,2-s2.0-85079757744,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Maxmen A.,36867482000;,More than 80 clinical trials launch to test coronavirus treatments,2020,Nature,578,7795,,347,348,,4,10.1038/d41586-020-00444-3,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079612991&doi=10.1038%2fd41586-020-00444-3&partnerID=40&md5=1946212d0a85e4a9b9e32129d4825791,,"Maxmen, A.",[No abstract available],Diseases; Drug discovery; Infection; Virology,,,,,NLM (Medline),14764687,,,32071447,English,Nature,Note,Final,Open Access,Scopus,2-s2.0-85079612991,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Liao X., Wang B., Kang Y.",8320293500;57214916841;35169843000;,"Novel coronavirus infection during the 2019–2020 epidemic: preparing intensive care units—the experience in Sichuan Province, China",2020,Intensive Care Medicine,46,2,,357,360,,5,10.1007/s00134-020-05954-2,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079479827&doi=10.1007%2fs00134-020-05954-2&partnerID=40&md5=7abdb1544a808fa15835ec8ec135820a,"Sichuan University West China Hospital, Chengdu, Sichuan, China","Liao, X., Sichuan University West China Hospital, Chengdu, Sichuan, China; Wang, B., Sichuan University West China Hospital, Chengdu, Sichuan, China; Kang, Y., Sichuan University West China Hospital, Chengdu, Sichuan, China",[No abstract available],,2019 novel coronavirus; Article; China; Coronavirinae; Coronavirus infection; disease classification; disease severity; epidemic; human; infection control; intensive care; medical staff; protection; staff training,"Huang, C.L., Wang, Y., Li, X.W., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet; Chen Wang, H.P., Hayden, F.G., Gao, G.F., A novel coronavirus outbreak of global health concern (2020) Lancet; Read, J.M., Bridgen, J.R.E., Cummings, D.A.T., Ho, A., Jewell, C.P., Novel coronavirus 2019-nCoV: early estimation of epidemiological parameters and epidemic (2020) BMJ; Maves, R.C., Jamros, C.M., Smith, A.G., Intensive care unit preparedness during pandemics and other biological threats (2019) Crit Care Clin, 35 (4), pp. 609-618; Wong, A.T.Y., Chen, H., Liu, S.H., Hsu, E.K., Luk, K.S., Lai, C.K.C., Chan, R.F.Y., Tsang, D.N.C., From SARS to avian influenza preparedness in Hong Kong (2017) Clin Infect Dis, 64, pp. S98-S104; (2020) Infection Prevention and Control during Health Care When Novel Coronavirus (Ncov) Infection is Suspected (2020), , https://www.who.int/publications-detail/infection-prevention-and-control-during-health-care-when-novel-coronavirus-(ncov)-infection-is-suspected-20200125, Accessed 28 Jan 2020; Martinez, L., Cheng, W., Wang, X., Ling, F., Mu, L., Li, C., Huo, X., Shen, Y., A risk classification model to predict mortality among laboratory-confirmed avian influenza A H7N9 patients: a population-based observational cohort study (2019) J Infect Dis, 220 (11), pp. 1780-1789; Redfern, O.C., Smith, G.B., Prytherch, D.R., Meredith, P., Inada-Kim, M., Schmidt, P.E., A comparison of the quick sequential (sepsis-related) organ failure assessment score and the national early warning score in non-ICU patients with/without infection (2018) Crit Care Med, 46 (12), pp. 1923-1933; Paules, C.I.M.H., Fauci, A.S., Coronavirus infections-more than just the common cold (2020) JAMA; Heimann, D.L., Data sharing and outbreaks: best practice exemplified (2020) Lancet","Kang, Y.; Sichuan University West China HospitalChina; email: kangyan@scu.edu.cn",,Springer,3424642,,ICMED,32025779,English,Intensive Care Med.,Article,Final,Open Access,Scopus,2-s2.0-85079479827,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Quilty B.J., Clifford S., Flasche S., Eggo R.M., CMMID nCoV working group",57215125608;51663266700;36096719400;36113351400;,Effectiveness of airport screening at detecting travellers infected with novel coronavirus (2019-nCoV),2020,Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin,25,5,,,,,2,10.2807/1560-7917.ES.2020.25.5.2000080,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079335354&doi=10.2807%2f1560-7917.ES.2020.25.5.2000080&partnerID=40&md5=f4a9636df14ee86b74d74d6f09bb1390,"Centre for the Mathematical Modelling of Infectious Diseases, Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom; These authors contributed equally to this work; members of the Centre for the Mathematical Modelling of Infectious Diseases (CMMID) nCoV working group are listed at the end of the article","Quilty, B.J., Centre for the Mathematical Modelling of Infectious Diseases, Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom; Clifford, S., Centre for the Mathematical Modelling of Infectious Diseases, Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom; Flasche, S., Centre for the Mathematical Modelling of Infectious Diseases, Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom, These authors contributed equally to this work; Eggo, R.M., Centre for the Mathematical Modelling of Infectious Diseases, Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom, These authors contributed equally to this work; CMMID nCoV working group","We evaluated effectiveness of thermal passenger screening for 2019-nCoV infection at airport exit and entry to inform public health decision-making. In our baseline scenario, we estimated that 46% (95% confidence interval: 36 to 58) of infected travellers would not be detected, depending on incubation period, sensitivity of exit and entry screening, and proportion of asymptomatic cases. Airport screening is unlikely to detect a sufficient proportion of 2019-nCoV infected travellers to avoid entry of infected travellers.",2019-nCoV; airport screening; effectiveness; emerging infections; interventions; surveillance; thermal scanning,"COVID-19; aviation; body temperature; communicable disease; Coronavirus infection; decision making; fever; health survey; human; mass screening; procedures; public health; theoretical model; virus pneumonia; Air Travel; Body Temperature; Communicable Diseases, Emerging; Coronavirus Infections; Decision Making; Fever; Humans; Mass Screening; Models, Theoretical; Pneumonia, Viral; Population Surveillance; Public Health",,,,NLM (Medline),15607917,,,32046816,English,Euro Surveill.,Article,Final,Open Access,Scopus,2-s2.0-85079335354,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, [No author name available],[No author id available],"CRISPR enhancement, coronavirus source and a controversial appointment",2020,Nature,578,7794,,196,197,,,10.1038/d41586-020-00360-6,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079334295&doi=10.1038%2fd41586-020-00360-6&partnerID=40&md5=efa0d36bdc9e5b00f0951ddcafdd4045,,,[No abstract available],Astronomy and astrophysics; Diseases; Funding; Genetics,,,,,NLM (Medline),14764687,,,32051606,English,Nature,Note,Final,Open Access,Scopus,2-s2.0-85079334295,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Eurosurveillance Editorial Team,36440437500;,Note from the editors: World Health Organization declares novel coronavirus (2019-nCoV) sixth public health emergency of international concern,2020,Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin,25,5,,,,,4,10.2807/1560-7917.ES.2020.25.5.200131e,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079331395&doi=10.2807%2f1560-7917.ES.2020.25.5.200131e&partnerID=40&md5=25a44ae3c7cfa3882f804dd74272bd6a,"European Centre for Disease Prevention and Control (ECDC)Stockholm, Sweden","Eurosurveillance Editorial Team, European Centre for Disease Prevention and Control (ECDC)Stockholm, Sweden",[No abstract available],,"COVID-19; China; Coronavirus infection; emergency; global health; human; international cooperation; public health; risk assessment; virus pneumonia; World Health Organization; China; Coronavirus Infections; Emergencies; Global Health; Humans; International Cooperation; Pneumonia, Viral; Public Health; Risk Assessment; World Health Organization",,,,NLM (Medline),15607917,,,32019636,English,Euro Surveill.,Article,Final,Open Access,Scopus,2-s2.0-85079331395,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, [No author name available],[No author id available],"Communication, collaboration and cooperation can stop the 2019 coronavirus",2020,Nature Medicine,26,2,,151,,,,10.1038/s41591-020-0775-x,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079317994&doi=10.1038%2fs41591-020-0775-x&partnerID=40&md5=28da0e59c6be1a966c65b0b494fd0d59,,,[No abstract available],,2019 novel coronavirus; China; cooperation; Coronavirinae; Coronavirus infection; Editorial; epidemic; human; interpersonal communication; intersectoral collaboration; Middle East respiratory syndrome coronavirus; phylogeny; priority journal; SARS coronavirus; virus spike; virus transmission; virus virulence,,,,Nature Research,10788956,,NAMEF,32015560,English,Nat. Med.,Editorial,Final,Open Access,Scopus,2-s2.0-85079317994,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, [No author name available],[No author id available],"HIV vaccine failure, coronavirus papers and a unprecedented glimpse of the Sun",2020,Nature,578,7793,,12,13,,,10.1038/d41586-020-00270-7,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079035643&doi=10.1038%2fd41586-020-00270-7&partnerID=40&md5=f14e8a5dce2d22fc982a3cb65475cfc9,,,[No abstract available],Astronomical instrumentation; Funding; Virology,,,,,NLM (Medline),14764687,,,32025023,English,Nature,Note,Final,Open Access,Scopus,2-s2.0-85079035643,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Callaway E.,23975660600;,China coronavirus: labs worldwide scramble to analyse live samples,2020,Nature,578,7793,,16,,,,10.1038/d41586-020-00262-7,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078987679&doi=10.1038%2fd41586-020-00262-7&partnerID=40&md5=1d18057eac73639667384dbaa9b48d62,,"Callaway, E.",[No abstract available],Infection; Virology,,,,,NLM (Medline),14764687,,,32020116,English,Nature,Note,Final,Open Access,Scopus,2-s2.0-85078987679,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Lewis D.,57210821122;,Coronavirus outbreak: what's next?,2020,Nature,578,7793,,15,16,,,10.1038/d41586-020-00236-9,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078961780&doi=10.1038%2fd41586-020-00236-9&partnerID=40&md5=670399450dea7a9e2d9cd5930dca83e8,,"Lewis, D.",[No abstract available],Events; Infection; Public health,nucleotide; Coronavirinae; epidemic; human; SARS coronavirus; severe acute respiratory syndrome; Coronavirus; Disease Outbreaks; Humans; Nucleotides; SARS Virus; Severe Acute Respiratory Syndrome,,,,NLM (Medline),14764687,,,32020111,English,Nature,Note,Final,Open Access,Scopus,2-s2.0-85078961780,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Bogner J.R.,7005719945;,Coronavirus: Are we at the beginning of a new pandemic? [Coronavirus: Stehen wir am Beginn einer neuen Pandemie?],2020,MMW-Fortschritte der Medizin,162,2,,8,10,,,10.1007/s15006-020-0080-0,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078889040&doi=10.1007%2fs15006-020-0080-0&partnerID=40&md5=a332705bfa5bead95d563e8dc7297d9f,"Medizinische Klinik und Poliklinik IV, Sektion Klinische Infektiologie, München, Germany","Bogner, J.R., Medizinische Klinik und Poliklinik IV, Sektion Klinische Infektiologie, München, Germany",[No abstract available],,Coronavirus infection; Note; pandemic,"Zhu, N., Zhang, D., Wang, W., A Novel Coronavirus from Patients with Pneumonia in China, 2019 (2020) N Engl J Med, , https://doi.org/10.1056/NEJMoa2001017; Perlman, S., Another Decade, Another Coronavirus (2020) N Engl J Med, , https://doi.org/10.1056/NEJMe2001126; (2020) Geographical Distribution of 2019-Ncov Cases, , ECDC; Munster, V.J., Koopmans, M., van Doremalen, N., van Riel, D., de Wit, E., A Novel Coronavirus Emerging in China — Key Questions for Impact Assessment (2020) N Engl J Med, , https://doi.org/10.1056/NEJMp2000929","Bogner, J.R.; Medizinische Klinik und Poliklinik IV, Sektion Klinische InfektiologieGermany",,Springer Medizin,14383276,,MFMEF,32016738,German,MMW-Fortschr. Med.,Note,Final,,Scopus,2-s2.0-85078889040,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Hui D.S., I Azhar E., Madani T.A., Ntoumi F., Kock R., Dar O., Ippolito G., Mchugh T.D., Memish Z.A., Drosten C., Zumla A., Petersen E.",7101862411;57213620547;57207894899;7004125689;57202637161;32867537600;57208096848;7007165041;7005059350;7003813990;7006170723;7202854790;,"The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health — The latest 2019 novel coronavirus outbreak in Wuhan, China",2020,International Journal of Infectious Diseases,91,,,264,266,,54,10.1016/j.ijid.2020.01.009,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077914756&doi=10.1016%2fj.ijid.2020.01.009&partnerID=40&md5=c29edc58df18abb17abcf15bc9f12dd6,"Department of Medicine & Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, Hong Kong; Special Infectious Agents Unit, King Fahd Medical Research Center and, Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia; Fondation Congolaise pour la Recherche Médicale, Brazzaville, Congo; The Royal Veterinary College, University of London, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire, United Kingdom; Chatham House Centre on Global Health Security, Royal Institute of International Affairs, London, United Kingdom; Lazzaro Spallanzani, National Institute for Infectious Diseases - IRCCS, Rome, Italy; Center for Clinical Microbiology, Division of Infection and Immunity, University College, London, United Kingdom; Infectious Diseases Division, Department of Medicine, Ministry of Health, Prince Mohamed Bin Abdulaziz Hospital, Riyadh, Saudi Arabia; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia; Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, United States; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Germany, Germany; Berlin Institute of Health, Institute of Virology, Berlin, Germany; German Centre for Infection Research, associated partner Charité, Berlin, Germany; Center for Clinical Microbiology, Division of Infection and Immunity, University College London, and NIHR Biomedical Research Centre, UCL Hospitals NHS Foundation Trust, London, United Kingdom; Directorate General for Disease Surveillance and Control, Ministry of Health, Muscat, Oman; Institute for Clinical Medicine, Faculty of Health Science, University of Aarhus, Aarhus, Denmark","Hui, D.S., Department of Medicine & Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong, Hong Kong; I Azhar, E., Special Infectious Agents Unit, King Fahd Medical Research Center and, Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia; Madani, T.A., Department of Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia; Ntoumi, F., Fondation Congolaise pour la Recherche Médicale, Brazzaville, Congo; Kock, R., The Royal Veterinary College, University of London, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire, United Kingdom; Dar, O., Chatham House Centre on Global Health Security, Royal Institute of International Affairs, London, United Kingdom; Ippolito, G., Lazzaro Spallanzani, National Institute for Infectious Diseases - IRCCS, Rome, Italy; Mchugh, T.D., Center for Clinical Microbiology, Division of Infection and Immunity, University College, London, United Kingdom; Memish, Z.A., Infectious Diseases Division, Department of Medicine, Ministry of Health, Prince Mohamed Bin Abdulaziz Hospital, Riyadh, Saudi Arabia, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia, Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, United States; Drosten, C., Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Germany, Germany, Berlin Institute of Health, Institute of Virology, Berlin, Germany, German Centre for Infection Research, associated partner Charité, Berlin, Germany; Zumla, A., Center for Clinical Microbiology, Division of Infection and Immunity, University College London, and NIHR Biomedical Research Centre, UCL Hospitals NHS Foundation Trust, London, United Kingdom; Petersen, E., Directorate General for Disease Surveillance and Control, Ministry of Health, Muscat, Oman, Institute for Clinical Medicine, Faculty of Health Science, University of Aarhus, Aarhus, Denmark",[No abstract available],,abdominal tumor; adult respiratory distress syndrome; case fatality rate; China; Coronavirus infection; coughing; dyspnea; Editorial; epidemic; fever; global health; human; leukopenia; liver cirrhosis; lymphocytopenia; malaise; Middle East respiratory syndrome; multiple organ failure; pneumonia; respiratory distress; respiratory failure; septic shock; severe acute respiratory syndrome; threat,"Azhar, E.I., Hui, D.S.C., Memish, Z.A., Drosten, C., Zumla, A., The Middle East Respiratory Syndrome (MERS) (2019) Infect Dis Clin North Am, 33 (4), pp. 891-905; Center for Health Protection, HKSAR, Press Release (2020), https://www.info.gov.hk/gia/general/202001/11/P2020011100233.htm, 11 Jan Accessed 12 Jan 2020. Available at:; Hui, D.S.C., Zumla, A., Severe acute respiratory syndrome: historical, epidemiologic, and clinical features (2019) Infect Dis Clin North Am, 33 (4), pp. 869-889; Parr, J., Pneumonia in China: lack of information raises concerns among Hong Kong health workers (2020) BMJ, 368, p. m56. , Published 8 January 2020; WHO, Emergencies preparedness, response. Pneumonia of unknown origin – China (2020) Disease outbreak news, , https://www.who.int/csr/don/05-january-2020-pneumonia-of-unkown-cause-china/en/, 5 January, Accessed 12 Jan 2020. Available at:; WHO, Emergencies preparedness, response. Pneumonia of unknown origin – China (2020) Disease outbreak news, , https://www.who.int/csr/don/12-january-2020-novel-coronavirus-china/en/, 12 January, Accessed 12 Jan 2020. Available at:; World Health Organization, SARS (Severe Acute Respiratory Syndrome) (2019), https://www.who.int/ith/diseases/sars/en/, -accessed 12th January, 2020; World Health Organization, MERS situation update (2019), http://applications.emro.who.int/docs/EMROPub_2019_MERA_apr_EN_23513.pdf?ua=1, (accessed August 20, 2019); Zumla, A., Dar, O., Kock, R., Taking forward a’ One Health’ approach for turning the tide against the Middle East respiratory syndrome coronavirus and other zoonotic pathogens with epidemic potential (2016) Int J Infect Dis, 47, pp. 5-9; https://www.ecohealthalliance.org/2020/01/phylogenetic-analysis-shows-novel-wuhan-coronavirus-clusters-with-sars, ProMED “Novel coronavirus - China (01): (HU) WHO, phylogenetic tree”. Archive Number: 20200112.6885385. Accessed 13 Jan 2020","Hui, D.S.; Special Infectious Agents Unit, King Fahd Medical Research Center and, Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz UniversitySaudi Arabia; email: dschui@cuhk.edu.hk",,Elsevier B.V.,12019712,,IJIDF,31953166,English,Int. J. Infect. Dis.,Editorial,Final,Open Access,Scopus,2-s2.0-85077914756,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Alburikan K.A., Abuelizz H.A.",55340550100;56667652300;,Identifying factors and target preventive therapies for Middle East Respiratory Syndrome sucsibtable patients,2020,Saudi Pharmaceutical Journal,28,2,,161,164,,,10.1016/j.jsps.2019.11.016,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077144014&doi=10.1016%2fj.jsps.2019.11.016&partnerID=40&md5=dfadd8a3d30dfa9b0fa90f5a39800fe7,"Department of Clincal Pharmacy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Saudi Arabia; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Saudi Arabia","Alburikan, K.A., Department of Clincal Pharmacy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Saudi Arabia; Abuelizz, H.A., Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Saudi Arabia","Background: Middle East Respiratory Syndrome (MERS) is a respiratory disease caused by a novel coronavirus that was identified in 2012 in Saudi Arabia. It is associated with significant mortality and morbidity. We identified factors associated with the Middle East Respiratory Syndrome-Coronavirus (MERS‐CoV) infection among suspected cases presented with sign and symptoms of upper respiratory infection or exposure to the virus. We also looked at the impact of medication history on virus transmission. Method: We included subjects with suspected MERS-CoV infection and confirmed cases of MERS infection. Subjects were excluded if there were any missing data that prevent the final analysis. Descriptive statistics were used to report demographic data. Percentages and frequencies were used to summarize the categorical variables, while means and standard deviations were calculated for continuous variables. Logistic regression was used to assess the risk of MERS-CoV infection among the suspected cases. A value of p < 0.05 was considered statistically significant. Results: A total of 16,189 suspected cases were identified, complete data were analyzed for 3154 to assess factors that are independently associated with MERS-CoV infection. MERS-CoV infection was associated with age (adjusted odds ratio [AOR] = .1.06; 95% CI [1.02–1.098], P-value = .0.004), male gender (AOR = .1.617; 95% CI [1.365–1.77], P-value < 0.001) and diabetes (AOR = .1.68; 95% CI [1.346–1.848], P-value = .0.002. There was no significant association with the other comorbidities. Medication history was not associated with an increase or decrease the likelihood of the infection. Conclusions: MERS-Cov infection is more common in male, advanced age and diabetes. No medications were associated with an increase or decrease the likelihood of the infection. This is important to focus on screening and detection to this patient population. © 2019",Diabetes; MERS-CoV; Middle East Respiratory Syndrome,angiotensin receptor antagonist; beta adrenergic receptor blocking agent; dipeptidyl carboxypeptidase inhibitor; dipeptidyl peptidase IV inhibitor; diuretic agent; metformin; sulfonylurea derivative; adult; age; Article; asthma; chronic kidney failure; chronic obstructive lung disease; comorbidity; demography; diabetes mellitus; disease association; female; gender; human; hypertension; infection prevention; infection risk; major clinical study; male; medical history; Middle East respiratory syndrome; Middle East respiratory syndrome coronavirus; retrospective study; risk assessment; risk factor; susceptible population; viral upper respiratory tract infection; virus transmission,"Aleanizy, F.S., Mohmed, N., Alqahtani, F.Y., Mohamed, R.A.E.H., Outbreak of middle east respiratory syndrome coronavirus in Saudi Arabia: a retrospective study (2017) BMC Infect. Dis., 17 (1), pp. 445-449; Assiri, A., Hospital outbreak of Middle East respiratory syndrome coronavirus (2013) N. Engl. J. Med., 369 (5), pp. 407-416; Chan, J.F.W., Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease (2015) Clin. Microbiol. Rev., 28 (2), pp. 465-522; Chen, X., Chughtai, A.A., Dyda, A., MacIntyre, C.R., Comparative epidemiology of Middle East Respiratory Syndrome coronavirus (MERS-CoV) in Saudi Arabia and South Korea (2017) Emerging Microbes Infect., 6 (1), pp. 1-6; Cotten, M., Transmission and evolution of the Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive genomic study (2013) The Lancet, 382 (9909), pp. 1993-2002; de Groot, R.J., Middle East Respiratory syndrome coronavirus (MERS-CoV): announcement of the coronavirus study group (2013) J. Virol., 87 (14), pp. 7790-7792; Guery, B., Clinical features and viral diagnosis of two cases of infection with Middle East respiratory syndrome coronavirus: a report of nosocomial transmission (2013) The Lancet, 381 (9885), pp. 2265-2272; (2019), https://www.who.int/csr/disease/coronavirus_infections/risk-assessment-august-2018.pdf, Middle East Respiratory Syndrome Coronavirus (MERS-CoV) WHO MERS Global Summary and Assessment of Risk Global Summary, 2018. (May 11, 2019).Accessed April; Raj, V.S., Dipeptidyl peptidase 4 Is a functional receptor for the emerging human coronavirus-EMC (2013) Nature, 495 (7440), pp. 251-254; Rivers, C.M., Majumder, M.S., Lofgren, E.T., Risks of Death and severe disease in patients with Middle East respiratory syndrome coronavirus, 2012–2015 (2016) Am. J. Epidemiol., 184 (6), pp. 460-464; Zumla, A., Hui, D.S., Perlman, S., Middle East respiratory syndrome (2015) Lancet, 386 (9997), pp. 995-1007","Abuelizz, H.A.; College of Pharmacy, King Saud University, P.O. Box 2475, Saudi Arabia; email: habuelizz@ksu.edu.sa",,Elsevier B.V.,13190164,,SPJOE,,English,Saudi Pharm. J.,Article,Final,Open Access,Scopus,2-s2.0-85077144014,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Shin Y.S., Jarhad D.B., Jang M.H., Kovacikova K., Kim G., Yoon J.-S., Kim H.-R., Hyun Y.E., Tipnis A.S., Chang T.-S., van Hemert M.J., Jeong L.S.",57196417379;56469732000;57208018023;57194004967;56412298300;57191746584;57191723553;57193415143;36088118500;7404726037;55291601300;57202587840;,Identification of 6′-β-fluoro-homoaristeromycin as a potent inhibitor of chikungunya virus replication,2020,European Journal of Medicinal Chemistry,187,,111956,,,,,10.1016/j.ejmech.2019.111956,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85076250545&doi=10.1016%2fj.ejmech.2019.111956&partnerID=40&md5=0e47bd82c33cef277f59a17663300594,"Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, South Korea; Department of Medical Microbiology, Leiden University Medical Center, Albinusdreef 2, 2333ZA, Leiden, Netherlands","Shin, Y.S., Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, South Korea; Jarhad, D.B., Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, South Korea; Jang, M.H., Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, South Korea; Kovacikova, K., Department of Medical Microbiology, Leiden University Medical Center, Albinusdreef 2, 2333ZA, Leiden, Netherlands; Kim, G., Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, South Korea; Yoon, J.-S., Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, South Korea; Kim, H.-R., Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, South Korea; Hyun, Y.E., Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, South Korea; Tipnis, A.S., Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, South Korea; Chang, T.-S., Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, South Korea; van Hemert, M.J., Department of Medical Microbiology, Leiden University Medical Center, Albinusdreef 2, 2333ZA, Leiden, Netherlands; Jeong, L.S., Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul, 08826, South Korea","We have reported on aristeromycin (1) and 6′-fluorinated-aristeromycin analogues (2), which are active against RNA viruses such as Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus (SARS-CoV), Zika virus (ZIKV), and Chikungunya virus (CHIKV). However, these exhibit substantial cytotoxicity. As this cytotoxicity may be attributed to 5′-phosphorylation, we designed and synthesized one-carbon homologated 6′-fluorinated-aristeromycin analogues. This modification prevents 5′-phosphorlyation by cellular kinases, whereas the inhibitory activity towards S-adenosyl-L-homocysteine (SAH) hydrolase will be retained. The enantiomerically pure 6′-fluorinated-5′-homoaristeromycin analogues 3a-e were synthesized via the electrophilic fluorination of the silyl enol ether with Selectfluor, using a base-build up approach as the key steps. All synthesized compounds exhibited potent inhibitory activity towards SAH hydrolase, among which 6′-β-fluoroadenosine analogue 3a was the most potent (IC50 = 0.36 μM). Among the compounds tested, 6′-β-fluoro-homoaristeromycin 3a showed potent antiviral activity (EC50 = 0.12 μM) against the CHIKV, without noticeable cytotoxicity up to 250 μM. Only 3a displayed anti-CHIKV activity, whereas both3a and 3b inhibited SAH hydrolase with similar IC50 values (0.36 and 0.37 μM, respectively), which suggested that 3a's antiviral activity did not merely depend on the inhibition of SAH hydrolase. This is further supported by the fact that the antiviral effect was specific for CHIKV and some other alphaviruses and none of the homologated analogues inhibited other RNA viruses, such as SARS-CoV, MERS-CoV, and ZIKV. The potent inhibition and high selectivity index make 6′-β-fluoro-homoaristeromycin (3a) a promising new template for the development of antivirals against CHIKV, a serious re-emerging pathogen that has infected millions of people over the past 15 years. © 2019 Elsevier Masson SAS",6′-fluorohomoaristeromycin; Anti-RNA virus; Chikungunya; Electrophilic fluorination; S-adenosylhomocysteine hydrolase,"2 (5,5 difluoro 2,2 dimethyl 6 [6 (methylamino) 9 purin 9 yl]tetrahydro 4h cyclopenta[d][1,3]dioxol 4 yl]ethan 1 ol; 2 [6 (6 amino 9h purin 9 yl) 5,5 difluoro 2,2 dimethyltetrahydro 4h cyclopenta[d][1,3]dioxol 4 yl]ethan 1 ol; 2 [6 (6 chloro 9h purin 9 yl) 5,5 difluoro 2,2 dimethyltetrahydro 4h cyclopenta[d][1,3]dioxol 4 yl]ethan 1 ol; 3 (6 amino 9h purin 9 yl) 4 fluoro 5 (2 hydroxyethyl)cyclopentane 1,2 diol; 3 (6 chloro 9h purin 9 yl) 4 fluoro 5 (2 hydroxyethyl)cyclopentane 1,2 diol; 4 fluoro 3 (2 hydroxyethyl) 5 [6 (methylamino) 9h purin 9 yl]cyclopentane 1,2 diol; 6 [2 [(tert butyldiphenylsilyl)oxy]ethyl] 5 fluoro 2,2 dimethyltetrahydro 4h cyclopenta[d][1,3]dioxol 4 ol; 6 [2 [(tert butyldiphenylsilyl)oxy]ethyl] 5,5 difluoro 2,2 dimethyltetrahydro 4h cyclopenta[d][1,3]dioxol 4 ol; 6' beta fluoro homoaristeromycin; 9 [2 fluoro 4,5 dihydroxy 3 (2 hydroxyethyl)cyclopentyl] 1,9 dihydro 6h purin 6 one; 9 [6 [2 [(tert butyldiphenylsilyl)oxy]ethyl] 5 fluoro 2,2 dimethyltetrahydro 4h cyclopenta[d][1,3]dioxol 4 yl] 6 chloro 9h purine; 9 [6 [2 [(tert butyldiphenylsilyl)oxy]ethyl] 5,5 difluoro 2,2 dimethyltetrahydro 4h cyclopenta[d][1,3]dioxol 4 yl] 6 chloro 9h purine; antivirus agent; aristeromycin; n [6 [2 [(tert butyldiphenylsilyl)oxy]ethyl] 5 fluoro 2,2 dimethyltetrahydro 4h cyclopenta[d][1,3]dioxol 4 yl] 6 chloropyrimidine 4,5 diamine; unclassified drug; [2 (6 azido 5 fluoro 2,2 dimethyltetrahydro 4h cyclopenta[d][1,3]dioxol 4 yl)ethoxy](tert butyl)diphenylsilane; [2 (6 azido 5,5 difluoro 2,2 dimethyltetrahydro 4h cyclopenta[d][1,3]dioxol 4 yl)ethoxy](tert butyl)diphenylsilane; antivirus agent; antiviral activity; Article; CC50 (cytotoxic concentration); chikungunya; Chikungunya virus; cytopathogenic effect; drug cytotoxicity; drug potency; drug synthesis; EC50; electrophilicity; IC50; Michael addition; Middle East respiratory syndrome coronavirus; nonhuman; polymerization; proton nuclear magnetic resonance; ring closing metathesis; SARS coronavirus; selectivity index; stereochemistry; stereoisomerism; virus replication; Zika virus; chemical structure; chemistry; dose response; drug effect; microbial sensitivity test; molecular model; structure activity relation; synthesis; virus replication; X ray crystallography; Antiviral Agents; Chikungunya virus; Crystallography, X-Ray; Dose-Response Relationship, Drug; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Structure-Activity Relationship; Virus Replication","Payne, S., Viruses from Understanding to Investigation (2018), pp. 97-105. , Academic Press (Chapter 10), Introduction to RNA viruses; Baltimore, D., Expression of animal virus genomes (1971) Bacteriol. Rev., 35, pp. 235-241; Thiel, V., (2007) Coronaviruses: Molecular and Cellular Biology, , first ed. Caister Academic Press; Zumla, A., Hui, D.S., Perlman, S., Middle east respiratory syndrome (2015) Lancet, 386, pp. 995-1007; Musso, D., Gubler, D.J., Zika virus (2016) Clin. Microbiol. Rev., 29, pp. 487-524; Agumadu, V.C., Ramphul, K., Zika virus: a review of literature (2018) Cureus, 10; Caglioti, C., Lalle, E., Castilletti, C., Carletti, F., Capobianchi, M.R., Bordi, L., Chikungunya virus infection: an overview (2013) New Microbiol., 36, pp. 211-227; Turner, M.A., Yang, X., Yin, D., Kuczera, K., Borchardt, R.T., Howell, P.L., Structure and function of S-adenosylhomocysteine hydrolase (2000) Cell Biochem. Biophys., 33, pp. 101-125; Cantoni, G.L., The centrality of S-adenosylhomocysteinase in the regulation of the biological utilization of S-adenosylmethionine (1986) Biological Methylation and Drug Design, pp. 227-238. , R.T. Borchardt C.R. Creveling P.M. Ueland Humana Press Clifton, NJ; Wolfe, M.S., Borchardt, R.T., Adenosyl-L-homocysteine, S., Hydrolase as a target for antiviral chemotherapy (1991) J. Med. Chem., 34, pp. 1521-1530; De Clercq, E., Strategies in the design of antiviral drugs (2002) Nat. Rev. Drug Discov., 1, pp. 13-25; Snoeck, R., Andrei, G., Neyts, J., Schols, D., D, Cools, M., Balzarini, J., De Clercq, E., Inhibitory activity of S-adenosylhomocysteine hydrolase inhibitors against human cytomegalovirus replication (1993) Antivir. Res., 21, pp. 197-216; Chambers, T.J., Monath, T.P., (2003) The Flaviviruses: Detection, Diagnosis and Vaccine Development, pp. pp3-577. , Academic press; Tseng, C.K., Marquez, V.E., Fuller, R.W., Goldstein, B.M., Haines, D.R., Mcpherson, H., Parsons, J.L., Driscoll, J.S., Synthesis of 3-deazaneplanocin A, a powerful inhibitor of S-adenosylhomocysteine hydrolase with potent and selective in vitro and in vivo antiviral activities (1989) J. Med. Chem., 32, pp. 1442-1446; Bray, M., Driscoll, J.S., Huggins, J.W., Treatment of lethal Ebola virus infection in mice with a single dose of an S-adenosyl-L-homocysteine hydrolase inhibitor (2000) Antivir. Res., 45, pp. 135-147; Bray, M., Davis, K., Geisbert, T., Schmaljohn, C., Huggins, J.A., Mouse model for evaluation of prophylaxis and therapy of Ebola hemorrhagic fever (1999) J. Infect. Dis., 179, pp. S248-S258; Kusaka, T., Yamamoto, H., Shibata, M., Muro, M., Kishi, T., T, Mizuno, K., Streptomyces citricolor nov. sp. and a new antibiotic (1968) J. Antibiot. (Tokyo), 21, pp. 255-263; Shealy, Y.F., Clayton, J.D., 9-[β-DL-2α,3α-Dihydroxy-4β-(hydroxymethyl)- cyclopentyl]adenine, the carbocyclic analog of adenosine (1966) J. Am. Chem. Soc., 88, pp. 3885-3887; Shealy, Y.F., Clayton, J.D., Synthesis of carbocyclic analogs of purine ribonucleosides (1969) J. Am. Chem. Soc., 91, pp. 3075-3083; Shealy, Y.F., Thorpe, M.C., Coburn, W.C., Clayton, J.D., Identity of the synthetic carbocylic analog of adenosine and aristeromycin (1980) Chem. Pharm. Bull., 28, pp. 3114-3117; Arita, M., Adachi, K., Ito, Y., Sawai, H., Ohno, M., M, Enantioselective synthesis of the carbocyclic nucleosides (−)-aristeromycin and (−)-neplanocin A by a chemicoenzymatic approach (1983) J. Am. Chem. Soc., 105, pp. 4049-4055; Yoshikawa, M., Okaichi, Y., Cha, B.C., Kitagawa, I., Synthesis of (−)-aristeromycin from D-glucose (1990) Tetrahedron, 46, pp. 7459-7470; Wolfe, M.S., Lee, Y., Bartlett, W.J., Borcherding, D.R., Borchardt, R.T., 4’-Modified analogs of aristeromycin and neplanocin A: synthesis and inhibitory activity toward S-adenosyl-L-homocysteine hydrolase (1992) J. Med. Chem., 35, pp. 1782-1791; Madhavan, G.V., Martin, J.C., A novel and stereospecific synthesis of (±)- and (−)-aristeromycin (1986) J. Org. Chem., 51, pp. 1287-1293; Bennett, L.L., Jr., Allan, P.W., Rose, L.M., Comber, R.N., Secrist, J.A., III, Differences in the metabolism and metabolic effects of the carbocyclic adenosine analogs, neplanocin A and aristeromycin (1986) Mol. Pharmacol., 29, pp. 383-390; Bennett, L.L., Bowdon, B.J., Allan, P.W., Rose, L.M., Evidence that the carbocyclic analog of adenosine has different mechanisms of cytotoxicity to cells with adenosine kinase activity and to cells lacking this enzyme (1986) Biochem. Pharmacol., 35, pp. 4106-4109; Yoon, J.-S., Kim, G., Jarhad, D.B., Kim, H.-R., Shin, Y.S., Sahu, P.K., Kim, H.O., Jeong, L.S., Design, synthesis and anti-RNA virus activity of 6’-fluorinated-aristeromycin analogues (2019) J. Med. Chem., 62, pp. 6346-6362; Yang, M., Schneller, S.W., 5′-Homoaristeromycin, Synthesis and antiviral activity against orthopox viruses (2005) Bioorg. Med. Chem. Lett, 15, pp. 149-151; Kim, G., Yoon, J.-S., Jarhad, D.B., Shin, Y.S., Majik, M.S., Mulamoottil, V.A., Hou, X., Jeong, L.S., Asymmetric synthesis of (−)-6’-fluoro-aristeromycin via stereoselective electrophilic fluorination (2017) Org. Lett., 19, pp. 5732-5735; Jarhad, D.B., Jang, M.H., Shin, Y.S., Kim, G., Kim, H.-R., Hyun, Y.E., Yoon, J.S., Jeong, L.S., An efficient synthesis of fluoro-neplanocin A analogs using electrophilic fluorination and palladium-catalyzed dehydrosilylation (2019) Org. Chem. Front., 6, pp. 959-966; Yang, M., Ye, W., Schneller, S.W., Preparation of carbocyclic S-adenosylazamethionine accompanied by a practical synthesis of (−)-aristeromycin (2004) J. Org. Chem., 69, pp. 3993-3996; Crystal structure data for C12H16FN5O3 (3a) are as follows: Mr = 297.30, T = 296.5(2) K, orthorhombic, space group P212121, a = 10.34289(14) Å, b = 11.70521(15) Å, c = 15.2643(3) Å, α = 90°, β = 90°, γ = 90°, V = 1847.98(5) Å3, Z = 4, ρcalc = 1.069 g/cm3, μ = 0.728 mm-1, F(000) = 624.0, crystal size 0.146 × 0.086 × 0.013 mm3, radiation CuKα (λ = 1.54184). Of 22855 reflections collected in the 2θ range from 9.522 to 153.208° using an ω scan on a SuperNova, Dual, Cu at zero, AtlasS2 diffractometer, 3856 were unique reflections (Rint = 0.0310, Rsigma = 0.0180). Using Olex2, the structure was solved with the ShelXT structure solution program using Direct Methods and refined with the ShelXL refinement package using Least Squares minimization. Final R indexes [all data] R1 = 0.0367, wR2 = 0.1054, GOF = 1.057, and maxmin-1 residual electron density 0.23/-0.18 eÅ-3. Flack parameter = 0.12(7). Further details of the crystal structure investigation(s) may be obtained from the Cambridge Crystallographic Data Centre (CCDC, 12 Union Road, Cambridge, CB2 1EZ (UK); Tel: (+44)1223-336-408, Fax: (+44)1223-336033, e-mail: deposit@ccdc.cam.ac.kr) using no. CCDC 1963491","Jeong, L.S.; Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National UniversitySouth Korea; email: lakjeong@snu.ac.kr",,Elsevier Masson SAS,2235234,,EJMCA,31841728,English,Eur. J. Med. Chem.,Article,Final,Open Access,Scopus,2-s2.0-85076250545,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Stoian A., Rowland R.R.R., Petrovan V., Sheahan M., Samuel M.S., Whitworth K.M., Wells K.D., Zhang J., Beaton B., Cigan M., Prather R.S.",57194162590;7102266919;55370764400;57201285645;7102728185;6701782506;55166585800;55983810400;56740990100;57212604521;7102821990;,The use of cells from ANPEP knockout pigs to evaluate the role of aminopeptidase N (APN) as a receptor for porcine deltacoronavirus (PDCoV),2020,Virology,541,,,136,140,,,10.1016/j.virol.2019.12.007,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077209335&doi=10.1016%2fj.virol.2019.12.007&partnerID=40&md5=7fdaec6d56bf6c98951d8ebce3d62e5f,"Division of Animal Science, University of Missouri, Columbia, MO 65211, United States; Department of Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan, KS, United States; Genus plc, DeForestWI, United States; Veterinary Diagnostics and Production Animal Medicine, Iowa State University, Ames, IA, United States","Stoian, A., Department of Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan, KS, United States; Rowland, R.R.R., Department of Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan, KS, United States; Petrovan, V., Department of Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan, KS, United States; Sheahan, M., Department of Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan, KS, United States; Samuel, M.S., Division of Animal Science, University of Missouri, Columbia, MO 65211, United States; Whitworth, K.M., Division of Animal Science, University of Missouri, Columbia, MO 65211, United States; Wells, K.D., Division of Animal Science, University of Missouri, Columbia, MO 65211, United States; Zhang, J., Veterinary Diagnostics and Production Animal Medicine, Iowa State University, Ames, IA, United States; Beaton, B., Genus plc, DeForestWI, United States; Cigan, M., Genus plc, DeForestWI, United States; Prather, R.S., Division of Animal Science, University of Missouri, Columbia, MO 65211, United States","The coronaviruses, porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), and porcine deltacoronavirus (PDCoV) represent important sources of neonatal diarrhea on pig farms. The requirement for aminopeptidase N (APN) as a receptor for TGEV, but not for PEDV, is well established. In this study, the biological relevance of APN as a receptor for PDCoV was tested by using CRISPR/Cas9 to knockout the APN gene, ANPEP, in pigs. Porcine alveolar macrophages (PAMs) from ANPEP knockout (KO) pigs showed resistance to PDCoV infection. However, lung fibroblast-like cells, derived from the ANPEP KO PAM cultures, supported PDCoV infection to high levels. The results suggest that APN is a receptor for PDCoV in PAMs but is not necessary for infection of lung-derived fibroblast cells. The infection of the ANPEP KO pigs with PDCoV further confirmed that APN is dispensable as a receptor for PDCoV. © 2019 The Authors",Aminopeptidase N; ANPEP; APN; CD13; CRISPR; Porcine deltacoronavirus,microsomal aminopeptidase; animal cell; animal cell culture; animal tissue; ANPEP gene; Article; cell population; Coronavirinae; Coronavirus infection; CRISPR-CAS9 system; enzyme activity; gene knockout; infection prevention; lung alveolus macrophage; lung fibroblast; nonhuman; porcine deltacoronavirus; priority journal; swine disease; virus cell interaction,"Chen, Q., Gauger, P., Stafne, M., Thomas, J., Arruda, P., Burrough, E., Madson, D., Derscheid, R., Pathogenicity and pathogenesis of a United States porcine deltacoronavirus cell culture isolate in 5-day-old neonatal piglets (2015) Virology, 482, pp. 51-59; Delmas, B., Gelfi, J., L'Haridon, R., Vogel, L.K., Sjostrom, H., Noren, O., Laude, H., Aminopeptidase N is a major receptor for the entero-pathogenic coronavirus TGEV (1992) Nature, 357, pp. 417-420; Delmas, B., Gelfi, J., Kut, E., Sjostrom, H., Noren, O., Laude, H., Determinants essential for the transmissible gastroenteritis virus-receptor interaction reside within a domain of aminopeptidase-N that is distinct from the enzymatic site (1994) J. Virol., 68, pp. 5216-5224; Dveksler, G.S., Pensiero, M.N., Cardellichio, C.B., Williams, R.K., Jiang, G.S., Holmes, K.V., Dieffenbach, C.W., Cloning of the mouse hepatitis virus (MHV) receptor: expression in human and hamster cell lines confers susceptibility to MHV (1991) J. Virol., 65, pp. 6881-6891; Godet, M., Grosclaude, J., Delmas, B., Laude, H., Major receptor-binding and neutralization determinants are located within the same domain of the transmissible gastroenteritis virus (coronavirus) spike protein (1994) J. Virol., 68, pp. 8008-8016; Jung, K., Annamalai, T., Lu, Z., Saif, L.J., Comparative pathogenesis of US porcine epidemic diarrhea virus (PEDV) strain PC21A in conventional 9-day-old nursing piglets vs. 26-day-old weaned pigs (2015) Vet. Microbiol., 178, pp. 31-40; Khatri, M., O'Brien, T.D., Chattha, K.S., Saif, L.J., Porcine lung mesenchymal stromal cells possess differentiation and immunoregulatory properties (2015) Stem Cell Res. Ther., 6, p. 222; Li, W., Hulswit, R.J.G., Kenney, S.P., Widjaja, I., Jung, K., Alhamo, M.A., van Dieren, B., Bosch, B.J., Broad receptor engagement of an emerging global coronavirus may potentiate its diverse cross-species transmissibility (2018) Proc. Natl. Acad. Sci., 115, pp. E5135-E5143; Li, W., Moore, M.J., Vasilieva, N., Sui, J., Wong, S.K., Berne, M.A., Somasundaran, M., Farzan, M., Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus (2003) Nature, 426. , 450–254; Madson, D.M., Arruda, P.H., Magstadt, D.R., Burrough, E.R., Hoang, H., Sun, D., Bower, L.P., Yoon, K.J., Characterization of porcine epidemic diarrhea virus isolate US/Iowa/18984/2013, infection in 1-day-old cesarean-derived colostrum-deprived piglets (2016) Vet. Pathol., 53, pp. 44-52; Raj, V.S., Mou, H., Smits, S.L., Dekkers, D.H., Müller, M.A., Dijkman, R., Muth, D., Haagmans, B.L., Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC (2013) Nature, 495, pp. 251-254; Reed, J.L., Muench, H., A simple method of estimating fifty percent endpoints (1938) Am. J. Hygiene, 27, pp. 493-497; Saif, L.J., Pensaert, M.B., Sestak, K., Yeo, S., Jung, K., Coronaviruses (2012) Diseases of Swine, pp. 501-524. , J.J. Zimmerman L.A. Karriker A. Ramirez K.J. Schwartz G.W. Stevenson tenth ed. Wiley New York; Stevenson, G.W., Hoang, H., Schwartz, K.J., Burrough, E.R., Sun, D., Madson, D., Cooper, V.L., Yoon, K.J., Emergence of Porcine epidemic diarrhea virus in the United States: clinical signs, lesions, and viral genomic sequences (2013) J. Vet. Diagn. Investig., 25, pp. 649-654; Thomas, J.T., Chen, Q., Gauger, P.C., Gimenez-Lirola, L.G., Sinha, A., Harmon, K.M., Madson, D.M., Zhang, J., Effect of porcine epidemic diarrhea virus infectious doses on infection outcomes in naive conventional neonatal and weaned pigs (2015) PLoS One, 10; Vitosh-Sillman, S., Loy, J.D., Brodersen, B., Kelling, C., Doster, A., Topliff, C., Nelson, E., Hesse, R., Experimental infection of conventional nursing pigs and their dams with Porcine deltacoronavirus (2016) J. Vet. Diagn. Investig., 28, pp. 486-497; Wang, B., Liu, Y., Ji, C.M., Yang, Y.L., Liang, Q.Z., Zhao, P., Xu, L.D., Qin, P., Porcine deltacoronavirus engages the transmissible gastroenteritis virus functional receptor porcine aminopeptidase N for infectious cellular entry (2018) J. Virol., 92. , e00318-18; Wang, L., Byrum, B., Zhang, Y., Detection and genetic characterization of deltacoronavirus in pigs, Ohio, USA (2014) Emerg. Infect. Dis., 20, pp. 1227-1230; Wells, K.D., Bardot, R., Whitworth, K.M., Trible, B.R., Fang, Y., Mileham, A., Kerrigan, M.A., Rowland, R.R.R., Replacement of porcine CD163 scavenger receptor cysteine-rich domain 5 with a CD163-like homolog confers resistance of pigs to genotype 1 but not genotype 2 porcine reproductive and respiratory syndrome virus (2017) J. Virol., 91. , e01521-1516; Whitworth, K.M., Benne, J.A., Spate, L.D., Murphy, S.L., Samuel, M.S., Murphy, C.N., Richt, J.A., Wells, K.D., Zygote injection of CRISPR/Cas9 RNA successfully modifies the target gene without delaying blastocyst development or altering the sex ratio in pigs (2017) Transgenic Res., 26, pp. 97-107; Whitworth, K.M., Rowland, R.R.R., Petrovan, V., Sheahan, M., Cino-Ozuna, A.G., Fang, Y., Hesse, R., Prather, R.S., Resistance to coronavirus infection in amino peptidase N-deficient pigs (2018) Transgenic Res., 28, pp. 21-32; Zhu, X., Liu, S., Wang, X., Luo, Z., Shi, Y., Wang, D., Peng, G., Xiao, S., Contribution of porcine aminopeptidase N to porcine deltacoronavirus infection (2018) Emerg. Microb. Infect., 7, p. 65","Prather, R.S.; Division of Animal Science, University of MissouriUnited States; email: PratherR@missouri.edu",,Academic Press Inc.,426822,,VIRLA,32056711,English,Virology,Article,Final,Open Access,Scopus,2-s2.0-85077209335,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Peng Q., Fang L., Ding Z., Wang D., Peng G., Xiao S.",56564688800;7402470374;56152913000;36060664000;56651662900;7402022567;,Rapid manipulation of the porcine epidemic diarrhea virus genome by CRISPR/Cas9 technology,2020,Journal of Virological Methods,276,,113772,,,,,10.1016/j.jviromet.2019.113772,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85075009567&doi=10.1016%2fj.jviromet.2019.113772&partnerID=40&md5=bf3f463328940273a5c7772210be058a,"State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 430070, China; Jiangxi Provincial Key Laboratory for Animal Science and Technology, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, 330045, China","Peng, Q., State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 430070, China; Fang, L., State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 430070, China; Ding, Z., State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 430070, China, Jiangxi Provincial Key Laboratory for Animal Science and Technology, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, 330045, China; Wang, D., State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 430070, China; Peng, G., State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 430070, China; Xiao, S., State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, 430070, China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, 430070, China","Porcine epidemic diarrhea virus (PEDV) is a highly pathogenic enteric coronavirus causing lethal watery diarrhea in suckling piglets. Reverse genetics is a valuable tool to study the functions of viral genes and to generate vaccine candidates. In this study, a full-length infectious cDNA clone of the highly virulent PEDV strain AJ1102 was assembled in a bacterial artificial chromosome (BAC). The rescued virus (rAJ1102) exhibited similar proliferation characteristics in vitro to the wildtype AJ1102. Using CRISPR/Cas9 technology, a recombinant virus rAJ1102-ΔORF3-EGFP in which the ORF3 gene was replaced with an EGFP gene, was successfully generated, and its proliferation characteristics were compared with the parental rAJ1102. Importantly, it just took one week to construct the recombinant PEDV rAJ1102-ΔORF3-EGFP using this method, providing a more efficient platform for PEDV genome manipulation, which could also be applied to other RNA viruses. © 2019 Elsevier B.V.",CRISPR/Cas9; Porcine epidemic diarrhea virus; Reverse genetics system,"article; bacterial artificial chromosome; cell proliferation; CRISPR-CAS9 system; in vitro study; molecular cloning; nonhuman; Porcine epidemic diarrhea virus; reverse genetics; virus genome; virus recombinant; virus strain; animal; Coronavirus infection; CRISPR Cas system; genetic recombination; genetics; pig; Porcine epidemic diarrhea virus; swine disease; virology; virus genome; virus vaccine; Animals; Coronavirus Infections; CRISPR-Cas Systems; Genome, Viral; Porcine epidemic diarrhea virus; Recombination, Genetic; Swine; Swine Diseases; Viral Vaccines","Beall, A., Yount, B., Lin, C.M., Hou, Y., Wang, Q., Saif, L., Baric, R., Characterization of a pathogenic full-length cDNA clone and transmission model for porcine epidemic diarrhea virus strain PC22A (2016) mBio, 7, pp. e01451-15; Bi, J., Zeng, S., Xiao, S., Chen, H., Fang, L., Complete genome sequence of porcine epidemic diarrhea virus strain AJ1102 isolated from a suckling piglet with acute diarrhea in China (2012) J. Virol., 86, pp. 10910-10911; Ding, Z., Fang, L., Jing, H., Zeng, S., Wang, D., Liu, L., Zhang, H., Xiao, S., Porcine epidemic diarrhea virus nucleocapsid protein antagonizes beta interferon production by sequestering the interaction between IRF3 and TBK1 (2014) J. Virol., 88, pp. 8936-8945; Duarte, M., Gelfi, J., Lambert, P., Rasschaert, D., Laude, H., Genome organization of porcine epidemic diarrhoea virus (1993) Adv. Exp. Med. Biol., 342, pp. 55-60; Fan, B., Yu, Z., Pang, F., Xu, X., Zhang, B., Guo, R., He, K., Li, B., Characterization of a pathogenic full-length cDNA clone of a virulent porcine epidemic diarrhea virus strain AH2012/12 in China (2017) Virology, 500, pp. 50-61; Hou, Y., Lin, C.M., Yokoyama, M., Yount, B.L., Marthaler, D., Douglas, A.L., Ghimire, S., Wang, Q., Deletion of a 197-Amino-Acid region in the N-Terminal domain of spike protein attenuates porcine epidemic diarrhea virus in piglets (2017) J. Virol., 91, pp. e00227-17; Hou, Y., Meulia, T., Gao, X., Saif, L.J., Wang, Q., Deletion of both the tyrosine-based endocytosis signal and the endoplasmic reticulum retrieval signal in the cytoplasmic tail of spike protein attenuates porcine epidemic diarrhea virus in pigs (2019) J. Virol., 93, pp. e01758-18; Jengarn, J., Wongthida, P., Wanasen, N., Frantz, P.N., Wanitchang, A., Jongkaewwattana, A., Genetic manipulation of porcine epidemic diarrhoea virus recovered from a full-length infectious cDNA clone (2015) J. Gen. Virol., 96, pp. 2206-2218; Jiang, W., Zhao, X., Gabrieli, T., Lou, C., Ebenstein, Y., Zhu, T.F., Cas9-Assisted Targeting of CHromosome segments CATCH enables one-step targeted cloning of large gene clusters (2015) Nat. Commun., 6, p. 8101; Jung, K., Saif, L.J., Porcine epidemic diarrhea virus infection: etiology, epidemiology, pathogenesis and immunoprophylaxis (2015) Vet. J., 204, pp. 134-143; Kaewborisuth, C., He, Q., Jongkaewwattana, A., The accessory protein ORF3 contributes to porcine epidemic diarrhea virus replication by direct binding to the spike protein (2018) Viruses, 10, p. E399; Kao, C.F., Chiou, H.Y., Chang, Y.C., Hsueh, C.S., Jeng, C.R., Tsai, P.S., Cheng, I.C., Chang, H.W., The characterization of immunoprotection induced by a cDNA clone derived from the attenuated Taiwan porcine epidemic diarrhea virus pintung 52 strain (2018) Viruses, 10, p. E543; Lee, C., Porcine epidemic diarrhea virus: an emerging and re-emerging epizootic swine virus (2015) Virol. J., 12, p. 193; Li, C., Li, Z., Zou, Y., Wicht, O., van Kuppeveld, F.J., Rottier, P.J., Bosch, B.J., Manipulation of the porcine epidemic diarrhea virus genome using targeted RNA recombination (2013) PLoS One, 8; Li, J., Jin, Z., Gao, Y., Zhou, L., Ge, X., Guo, X., Han, J., Yang, H., Development of the full-length cDNA clones of two porcine epidemic diarrhea disease virus isolates with different virulence (2017) PLoS One, 12; Li, W., Li, H., Liu, Y., Pan, Y., Deng, F., Song, Y., Tang, X., He, Q., New variants of porcine epidemic diarrhea virus, China, 2011 (2012) Emerg. Infect. Dis., 18, pp. 1350-1353; Mali, P., Yang, L., Esvelt, K.M., Aach, J., Guell, M., DiCarlo, J.E., Norville, J.E., Church, G.M., RNA-guided human genome engineering via Cas9 (2013) Science, 339, pp. 823-826; Moradpour, M., Abdulah, S.N.A., CRISPR/dCas9 platforms in plants: strategies and applications beyond genome editing (2019) Plant Biotechnol. J., , [Epub ahead of print]; Song, D., Moon, H., Kang, B., Porcine epidemic diarrhea: a review of current epidemiology and available vaccines (2015) Clin. Exp. Vaccine Res., 4, pp. 166-176; Song, D., Park, B., Porcine epidemic diarrhoea virus: a comprehensive review of molecular epidemiology, diagnosis, and vaccines (2012) Virus Genes, 44, pp. 167-175; Stevenson, G.W., Hoang, H., Schwartz, K.J., Burrough, E.R., Sun, D., Madson, D., Cooper, V.L., Yoon, K.J., Emergence of Porcine epidemic diarrhea virus in the United States: clinical signs, lesions, and viral genomic sequences (2013) J. Vet. Diagn. Invest., 25, pp. 649-654; Sun, D., Wang, X., Wei, S., Chen, J., Feng, L., Epidemiology and vaccine of porcine epidemic diarrhea virus in China: a mini-review (2016) J. Vet. Med. Sci., 78, pp. 355-363; Teeravechyan, S., Frantz, P.N., Wongthida, P., Chailangkarn, T., Jaru-Ampornpan, P., Koonpaew, S., Jongkaewwattana, A., Deciphering the biology of porcine epidemic diarrhea virus in the era of reverse genetics (2016) Virus Res., 226, pp. 152-171; Van Reeth, K., Pensaert, M., Prevalence of infections with enzootic respiratory and enteric viruses in feeder pigs entering fattening herds (1994) Vet. Rec., 135, pp. 594-597; Vlasova, A.N., Marthaler, D., Wang, Q., Culhane, M.R., Rossow, K.D., Rovira, A., Collins, J., Saif, L.J., Distinct characteristics and complex evolution of PEDV strains, North America, May 2013-February 2014 (2014) Emerg. Infect. Dis., 20, pp. 1620-1628; Wang, D., Ge, X., Chen, D., Li, J., Cai, Y., Deng, J., Zhou, L., Yang, H., The S gene is necessary but not sufficient for the virulence of porcine epidemic diarrhea virus novel variant strain BJ2011C (2018) J. Virol., 92, pp. e00603-18; Wang, J.W., Wang, A., Li, K., Wang, B., Jin, S., Reiser, M., Lockey, R.F., CRISPR/Cas9 nuclease cleavage combined with Gibson assembly for seamless cloning (2015) BioTechniques, 58, pp. 161-170; Wang, K., Lu, W., Chen, J., Xie, S., Shi, H., Hsu, H., Yu, W., Sun, B., PEDV ORF3 encodes an ion channel protein and regulates virus production (2012) FEBS Lett., 586, pp. 384-391; Wang, Q., Vlasova, A.N., Kenney, S.P., Saif, L.J., Emerging and re-emerging coronaviruses in pigs (2019) Curr. Opin. Virol., 34, pp. 39-49; Wongthida, P., Liwnaree, B., Wanasen, N., Narkpuk, J., Jongkaewwattana, A., The role of ORF3 accessory protein in replication of cell-adapted porcine epidemic diarrhea virus (PEDV) (2017) Arch. Virol., 162, pp. 2553-2563; Wood, E.N., An apparently new syndrome of porcine epidemic diarrhoea (1977) Vet. Rec., 100, pp. 243-244; Zhang, Q., Yoo, D., Immune evasion of porcine enteric coronaviruses and viral modulation of antiviral innate signaling (2016) Virus Res., 226, pp. 128-141","Xiao, S.; Laboratory of Animal Virology, College of Veterinary Medicine, Huazhong Agricultural University, Shi-zi-shan Street, China; email: vet@mail.hzau.edu.cn",,Elsevier B.V.,1660934,,JVMED,31712093,English,J. Virol. Methods,Article,Final,Open Access,Scopus,2-s2.0-85075009567,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Persky M.E., Jafarey Y.S., Christoff S.E., Maddox D.D., Stowell S.A., Norton T.M.",56402961100;56681225500;57214320179;57214317396;57214318178;57214317684;,Tick paralysis in a free-ranging bobcat (Lynx rufus),2020,Journal of the American Veterinary Medical Association,256,3,,362,364,,,10.2460/javma.256.3.362,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078592801&doi=10.2460%2fjavma.256.3.362&partnerID=40&md5=ef0651ff9305737ad401aa9b68cf574c,"Department of Animal Health, Jacksonville Zoo and Gardens, 370 Zoo Pkwy, Jacksonville, FL 32218, United States; Georgia Sea Turtle Center, 214 Stable Rd, Jekyll Island, GA 31527, United States; Jekyll Island Authority, 100 James Rd, Jekyll Island, GA 31527, United States","Persky, M.E., Department of Animal Health, Jacksonville Zoo and Gardens, 370 Zoo Pkwy, Jacksonville, FL 32218, United States; Jafarey, Y.S., Department of Animal Health, Jacksonville Zoo and Gardens, 370 Zoo Pkwy, Jacksonville, FL 32218, United States; Christoff, S.E., Department of Animal Health, Jacksonville Zoo and Gardens, 370 Zoo Pkwy, Jacksonville, FL 32218, United States; Maddox, D.D., Department of Animal Health, Jacksonville Zoo and Gardens, 370 Zoo Pkwy, Jacksonville, FL 32218, United States; Stowell, S.A., Georgia Sea Turtle Center, 214 Stable Rd, Jekyll Island, GA 31527, United States; Norton, T.M., Georgia Sea Turtle Center, 214 Stable Rd, Jekyll Island, GA 31527, United States, Jekyll Island Authority, 100 James Rd, Jekyll Island, GA 31527, United States","CASE DESCRIPTION A free-ranging male bobcat (Lynx rufus) was evaluated because of signs of pelvic limb paralysis. CLINICAL FINDINGS Physical examination of the anesthetized animal revealed tick infestation, normal mentation, and a lack of evidence of traumatic injuries. Radiography revealed no clinically relevant abnormalities. Hematologic analysis results were generally unremarkable, and serologic tests for exposure to feline coronavirus, FeLV, FIV, and Toxoplasma gondii were negative. Results of PCR assays for flea- and common tick-borne organisms other than Bartonella clarridgeiae were negative. TREATMENT AND OUTCOME Ticks were manually removed, and the patient received supportive care and fipronil treatment. The bobcat made a full recovery within 72 hours after treatment for ticks, and a presumptive diagnosis of tick paralysis was made. Identified tick species included Dermacenter variabilis, Amblyomma americanum, and Ixodes scapularis. CLINICAL RELEVANCE To the authors' knowledge, tick paralysis has not previously been reported in felids outside Australia. This disease should be considered a differential diagnosis in felids, including exotic cats, with signs of neuromuscular disease of unknown etiopathogenesis. © 2020 American Veterinary Medical Association. All rights reserved.",,fipronil; Amblyomma americanum; animal experiment; Article; blood analysis; convalescence; Dermacenter variabilis; Ixodes scapularis; Lynx rufus; male; nonhuman; paralysis; parasite identification; physical examination; polymerase chain reaction; radiography; serodiagnosis; tick; tick infestation,"Bowman, D.D., Lynn, R.C., Eberhard, M.L., (2003) Georgis' Parasitology for Veterinarians, pp. 1-114. , 8th ed. St Louis: Saunders; Nagamori, Y., Reichard, M.V., Parasitology expertise from the NCVP: Feline tick-borne diseases (2015) Today's Vet Pract, 5, pp. 69-74; Chomel, B.B., Kasten, R.W., Bartonellosis, an increasingly recognized zoonosis (2010) J Appl Microbiol, 109, pp. 743-750; Shaw, S.E., Haemobartonella and bartonella: Two very different diseases! (2003) Proceedings. World Small Anim Vet Assoc World Cong, 118; Atwell, R., Merck Veterinary Manual. Overview of Tick Paralysis, , www.merckvetmanual.com/nervoussystem/tick-paralysis/overview-of-tick-paralysis, Accessed Dec 10, 2018; Luttrell, M.P., Creekmore, L.H., Mertins, J.W., Avian tick paralysis caused by Ixodes brunneus in the southeastern United States (1996) J Wildl Dis, 32, pp. 133-136; Konjević, D., Janicki, Z., Severin, K., An outbreak of tick paralysis in free-ranging mouflon (Ovis ammon musimon) (2007) J Zoo Wildl Med, 38, pp. 585-587; Beyer, A.B., Grossman, M., Tick paralysis in a red Wolf (1997) J Wildl Dis, 33, pp. 900-902; Schull, D.N., Litster, A.L., Atwell, R.B., Tick toxicity in cats caused by Ixodes species in Australia: A review of published literature (2007) J Feline Med Surg, 9, pp. 487-493; Botzler, R.G., Albrecht, J., Schaefer, T., Tick paralysis in a western harvest mouse (1980) J Wildl Dis, 16, pp. 223-224; Jessup, D.A., Tick paralysis in a grey fox (1979) J Wildl Dis, 15, pp. 271-272","Persky, M.E.; Department of Animal Health, Jacksonville Zoo and Gardens, 370 Zoo Pkwy, United States; email: perskym@jacksonvillezoo.org",,American Veterinary Medical Association,31488,,JAVMA,31961273,English,J. Am. Vet. Med. Assoc.,Article,Final,,Scopus,2-s2.0-85078592801,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Langel S.N., Wang Q., Vlasova A.N., Saif L.J.",57045823000;55698230500;16246782500;57205309530;,Host factors affecting generation of immunity against porcine epidemic diarrhea virus in pregnant and lactating swine and passive protection of neonates,2020,Pathogens,9,2,130,,,,,10.3390/pathogens9020130,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079904748&doi=10.3390%2fpathogens9020130&partnerID=40&md5=64c49d94b064b06fe7b99164ba8b495c,"Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, United States; Food Animal Health Research Program, Ohio Agricultural Research and Development Center, College of Food, Agricultural and Environmental Sciences, Department of Veterinary Preventive Medicine, The Ohio State University, Wooster, OH 44691, United States","Langel, S.N., Duke Human Vaccine Institute, Duke University Medical Center, Durham, NC 27710, United States; Wang, Q., Food Animal Health Research Program, Ohio Agricultural Research and Development Center, College of Food, Agricultural and Environmental Sciences, Department of Veterinary Preventive Medicine, The Ohio State University, Wooster, OH 44691, United States; Vlasova, A.N., Food Animal Health Research Program, Ohio Agricultural Research and Development Center, College of Food, Agricultural and Environmental Sciences, Department of Veterinary Preventive Medicine, The Ohio State University, Wooster, OH 44691, United States; Saif, L.J., Food Animal Health Research Program, Ohio Agricultural Research and Development Center, College of Food, Agricultural and Environmental Sciences, Department of Veterinary Preventive Medicine, The Ohio State University, Wooster, OH 44691, United States","Porcine epidemic diarrhea virus (PEDV) is a highly virulent re‐emerging enteric coronavirus that causes acute diarrhea, dehydration, and up to 100% mortality in neonatal suckling piglets. Despite this, a safe and effective PEDV vaccine against highly virulent strains is unavailable, making PEDV prevention and control challenging. Lactogenic immunity induced via the gut-mammary gland‐secretory IgA (sIgA) axis, remains the most promising and effective way to protect suckling piglets from PEDV. Therefore, a successful PEDV vaccine must induce protective maternal IgA antibodies that passively transfer into colostrum and milk. Identifying variables that influence lymphocyte migration and IgA secretion during gestation and lactation is imperative for designing maternal immunization strategies that generate the highest amount of lactogenic immune protection against PEDV in suckling piglets. Because pregnancy‐associated immune alterations influence viral pathogenesis and adaptive immune responses in many different species, a better understanding of host immune responses to PEDV in pregnant swine may translate into improved maternal immunization strategies against enteric pathogens for multiple species. In this review, we discuss the role of host factors during pregnancy on antiviral immunity and their implications for generating protective lactogenic immunity in suckling neonates. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.",Gut‐mammary gland‐secretory IgA axis; IgA antibodies; Lactogenic immunity; Lymphocyte trafficking; PEDV; Pregnancy,,"",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Z., Dietary 25‐ Hydroxyvitamin D(3) Supplementation Alleviates Porcine Epidemic Diarrhea Virus Infection by Improving Intestinal Structure and Immune Response in Weaned Pigs (2019) Animals,9, p. 627; Chepngeno, J., Diaz, A., Paim, F.C., Saif, L.J., Vlasova, A.N., Rotavirus C: Prevalence in suckling piglets and development of virus‐like particles to assess the influence of maternal immunity on the disease development (2019) Vet. Res.,50, p. 84; Ozawa, M., Matsuu, A., Yonezawa, K., Igarashi, M., Okuya, K., Kawabata, T., Ito, K., Deguchi, E., Efficient Isolation of Swine Influenza Viruses by Age‐Targeted Specimen Collection (2015) J. Clin. Microbiol,53," pp. 1331-1338""","Langel, S.N.; Duke Human Vaccine Institute, Duke University Medical CenterUnited States; email: stephanie.langel@duke.edu",,MDPI AG,20760817,,,,English,Pathogens,Review,Final,Open Access,Scopus,2-s2.0-85079904748,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Fan P., Guan J., He W., Lv X., Hu S., Lan Y., Zhao K., Gao F., Li F., Fan G., He H., Li Z.",57212243831;56096313500;24306126900;56364728900;57196946337;36554399700;56565933600;57127418300;57212242172;57211434193;55267766000;56364739300;,miR-142a-3p promotes the proliferation of porcine hemagglutinating encephalomyelitis virus by targeting Rab3a,2020,Archives of Virology,165,2,,345,354,,,10.1007/s00705-019-04470-z,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85076267243&doi=10.1007%2fs00705-019-04470-z&partnerID=40&md5=8ee177c59d8d2a85f19184b6c24ede58,"Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China; State Key Laboratory of Genetically Engineered Veterinary Vaccines, Yebio Bioengineering Co., Ltd of Qingdao, Qingdao, China; Key Laboratory of Animal Resistant Biology of Shandong, Ruminant Disease Research Center, College of Life Sciences, Shandong Normal University, Jinan, China","Fan, P., Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China; Guan, J., Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China; He, W., Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China; Lv, X., Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China; Hu, S., Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China; Lan, Y., Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China; Zhao, K., Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China; Gao, F., Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China; Li, F., State Key Laboratory of Genetically Engineered Veterinary Vaccines, Yebio Bioengineering Co., Ltd of Qingdao, Qingdao, China; Fan, G., State Key Laboratory of Genetically Engineered Veterinary Vaccines, Yebio Bioengineering Co., Ltd of Qingdao, Qingdao, China; He, H., Key Laboratory of Animal Resistant Biology of Shandong, Ruminant Disease Research Center, College of Life Sciences, Shandong Normal University, Jinan, China; Li, Z., Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China, State Key Laboratory of Genetically Engineered Veterinary Vaccines, Yebio Bioengineering Co., Ltd of Qingdao, Qingdao, China","Porcine hemagglutinating encephalomyelitis virus (PHEV) is a typical neurotropic coronavirus that mainly invades the central nervous system (CNS) in piglets and causes vomiting and wasting disease. Emerging evidence suggests that PHEV alters microRNA (miRNA) expression profiles, and miRNA has also been postulated to be involved in its pathogenesis, but the mechanisms underlying this process have not been fully explored. In this study, we found that PHEV infection upregulates miR-142a-3p RNA expression in N2a cells and in the CNS of mice. Downregulation of miR-142a-3p by an miRNA inhibitor led to a significant repression of viral proliferation, implying that it acts as a positive regulator of PHEV proliferation. Using a dual-luciferase reporter assay, miR-142a-3p was found to bind directly bound to the 3’ untranslated region (3’UTR) of Rab3a mRNA and downregulate its expression. Knockdown of Rab3a expression by transfection with an miR-142a-3p mimic or Rab3a siRNA significantly increased PHEV replication in N2a cells. Conversely, the use of an miR-142a-3p inhibitor or overexpression of Rab3a resulted in a marked restriction of viral production at both the mRNA and protein level. Our data demonstrate that miR-142a-3p promotes PHEV proliferation by directly targeting Rab3a mRNA, and this provides new insights into the mechanisms of PHEV-related pathogenesis and virus-host interactions. © 2019, Springer-Verlag GmbH Austria, part of Springer Nature.",,"messenger RNA; microRNA; Mirn142 microRNA, mouse; Rab protein; small interfering RNA; 3' untranslated region; animal; Betacoronavirus 1; cell line; cell proliferation; Coronavirus infection; down regulation; genetics; HEK293 cell line; human; mouse; pig; tumor cell line; upregulation; veterinary medicine; virology; 3' Untranslated Regions; Animals; Betacoronavirus 1; Cell Line; Cell Line, Tumor; Cell Proliferation; Coronavirus Infections; Down-Regulation; HEK293 Cells; Humans; Mice; MicroRNAs; rab3A GTP-Binding Protein; RNA, Messenger; RNA, Small Interfering; Swine; Up-Regulation","Dong, B., Lu, H., Zhao, K., Liu, W., Gao, W., Lan, Y., Zhao, J., Gao, F., Identification and genetic characterization of porcine hemagglutinating encephalomyelitis virus from domestic piglets in China (2014) Arch Virol, 159, pp. 2329-2337. , COI: 1:CAS:528:DC%2BC2cXms1aju7Y%3D; 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Zhen, Y., Stenmark, H., Cellular functions of Rab GTPases at a glance (2015) J Cell Sci, 128, pp. 3171-3176. , COI: 1:CAS:528:DC%2BC28XmvVWmu78%3D; Li, Y.C., Bai, W.Z., Hirano, N., Hayashida, T., Taniguchi, T., Sugita, Y., Tohyama, K., Hashikawa, T., Neurotropic virus tracing suggests a membranous-coating-mediated mechanism for transsynaptic communication (2013) J Comp Neurol, 521, pp. 203-212. , COI: 1:CAS:528:DC%2BC38Xhslelur%2FK","Li, Z.; Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin UniversityChina; email: lizi@jlu.edu.cn",,Springer,3048608,,ARVID,31834525,English,Arch. Virol.,Article,Final,Open Access,Scopus,2-s2.0-85076267243,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Sardar T., Ghosh I., Rodó X., Chattopadhyay J.",55994966500;57193761508;6602555283;6602973315;,A realistic two-strain model for MERS-CoV infection uncovers the high risk for epidemic propagation,2020,PLoS Neglected Tropical Diseases,14,2, e0008065,,,,,10.1371/journal.pntd.0008065,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080833474&doi=10.1371%2fjournal.pntd.0008065&partnerID=40&md5=36ae049d5b3abe9536fa17c5b257fcc5,"Department of Mathematics, Dinabandhu Andrews College, Kolkata, India; Agricultural and Ecological Research Unit, Indian Statistical Institute, Kolkata, India; ICREA &CLIMA (Climate and Health Program), ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain","Sardar, T., Department of Mathematics, Dinabandhu Andrews College, Kolkata, India; Ghosh, I., Agricultural and Ecological Research Unit, Indian Statistical Institute, Kolkata, India; Rodó, X., ICREA &CLIMA (Climate and Health Program), ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain; Chattopadhyay, J., Agricultural and Ecological Research Unit, Indian Statistical Institute, Kolkata, India","Middle East Respiratory Syndrome Coronavirus (MERS-CoV) causes severe acute respiratory illness with a case fatality rate (CFR) of 35,5%. The highest number of MERS-CoV cases are from Saudi-Arabia, the major worldwide hotspot for this disease. In the absence of neither effective treatment nor a ready-to-use vaccine and with yet an incomplete understanding of its epidemiological cycle, prevention and containment measures can be derived from mathematical models of disease epidemiology. We constructed 2-strain models to predict past outbreaks in the interval 2012–2016 and derive key epidemiological information for Macca, Madina and Riyadh. We approached variability in infection through three different disease incidence functions capturing social behavior in response to an epidemic (e.g. Bilin-ear, BL; Non-monotone, NM; and Saturated, SAT models). The best model combination successfully anticipated the total number of MERS-CoV clinical cases for the 2015–2016 season and accurately predicted both the number of cases at the peak of seasonal incidence and the overall shape of the epidemic cycle. The evolution in the basic reproduction number (R0) warns that MERS-CoV may easily take an epidemic form. The best model correctly captures this feature, indicating a high epidemic risk (1≤R0≤2,5) in Riyadh and Macca and confirming the alleged co-circulation of more than one strain. Accurate predictions of the future MERS-CoV peak week, as well as the number of cases at the peak are now possible. These results indicate public health agencies should be aware that measures for strict containment are urgently needed before new epidemics take off in the region. © 2020 Sardar et al.",,Article; disease model; disease transmission; epidemic; genetic variability; hospitalization; human; incidence; Middle East respiratory syndrome; Middle East respiratory syndrome coronavirus; prediction; seasonal variation; social behavior; virus strain,"Sabir, J.S.M., Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia (2016) Science, 351, pp. 81-84. , https://doi.org/10.1126/science.aac8608, 26678874; Middle East Respiratory Syndrome Coronavirus (Mers-Cov), , http://www.moh.gov.sa/en/CCC/PressReleases/Pages/default.aspx?PageIndex=1(2017); East Respiratory Syndrome Coronavirus (MERS-CoV)—Saudi Arabia, , http://www.who.int/csr/don/06-july-2017-mers-saudi-arabia/en/(2017); Chowell, G., Blumberg, S., Simonsen, L., Miller, M.A., Viboud, C., Synthesizing data and models for the spread of MERS-CoV, 2013: Key role of index cases and hospital transmission (2014) Epidemics, 9, pp. 40-51. , https://doi.org/10.1016/j.epidem.2014.09.011, 25480133; Zaki, A.M., van Boheemen, S., Bestebroer, T.M., Osterhaus, A.D., Fouchier, R.A., Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia (2012) N. 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USA, 109 (50), pp. 20425-20430. , https://doi.org/10.1073/pnas.1208772109, 23184969; Yamana, T.K., Kandula, S., Shaman, J., Superensemble forecasts of dengue outbreaks (2016) J. R. Soc. Interface, 13 (123). , https://doi.org/10.1098/rsif.2016.0410, 27733698; Ray, E.L., Reich, N.G., Prediction of infectious disease epidemics via weighted density ensembles (2018) Ploscomput. Biol., 14 (2); Breban, R., Riou, J., Fontanet, A., Interhuman transmissibility of Middle East respiratory syndrome coronavirus: Estimation of pandemic risk (2013) The Lancet, 382 (9893), pp. 694-699; Cauchemez, S., Unraveling the drivers of MERS-CoV transmission (2016) Proc. Natl. Acad. Sci. USA, 113 (32), pp. 9081-9086. , https://doi.org/10.1073/pnas.1519235113, 27457935; Zumla, A., Hui, D.S., Perlman, S., Middle East respiratory syndrome (2015) The Lancet, 386 (9997), pp. 995-1007; Muth, D., Infectious Middle East respiratory syndrome coronavirus excretion and serotype variability based on live virus isolates from patients in Saudi Arabia (2015) J. Clin. Microbiol., 53 (9), pp. 2951-2955. , https://doi.org/10.1128/JCM.01368-15, 26157150; Capasso, V., Serio, G., A generalization of the Kermack-McKendrick deterministic epidemic model (1978) Math.Biosci, 42 (1-2), pp. 43-61; Wang, W., Epidemic models with nonlinear infection forces. Math.Biosci (2006) Eng, 3 (1), pp. 267-279; Xiao, D., Ruan, S., Global analysis of an epidemic model with nonmonotone incidence rate (2007) Math.Biosci., 208 (2), pp. 419-429. , https://doi.org/10.1016/j.mbs.2006.09.025, 17303186; (2016) Life Expectancy, , http://countryeconomy.com/demography/, Saudi Arabia; Lessler, J., Incubation periods of acute respiratory viral infections: A systematic review (2009) Lancet Infect. Dis, 9 (5), pp. 291-300. , https://doi.org/10.1016/S1473-3099(09)70069-6, 19393959; Assiri, A., Hospital outbreak of Middle East respiratory syndrome coronavirus (2013) N. Engl. J. Med, 2013 (369), pp. 407-416; Xia, Z.Q., Zhang, J., Xue, Y.K., Sun, G.Q., Jin, Z., Modeling the transmission of Middle East respirator syndrome corona virus in the Republic of Korea (2015) Plosone, 10 (12); Majumder, M.S., Rivers, C., Lofgren, E., Fisman, D., Estimation of MERS-coronavirus reproductive number and case fatality rate for the spring 2014 Saudi Arabia outbreak: Insights from publicly available data (2014) Ploscurrents, 6; Poletto, C., Colizza, V., Boëlle, P.Y., Quantifying spatiotemporal heterogeneity of MERS-CoV transmission in the Middle East region: A combined modelling approach (2016) Epidemics, 15 (1-9). , https://doi. org/, PMID: 27266844; Nishiura, H., Miyamatsu, Y., Chowell, G., Saitoh, M., Assessing the risk of observing multiple generations of Middle East respiratory syndrome (MERS) cases given an imported case (2015) Eurosurveillance, 20 (27), pp. 6-11; Poletto, C., Boëlle, P.Y., Colizza, V., Risk of MERS importation and onward transmission: A systematic review and analysis of cases reported to WHO (2016) BMC Infect.Dis., 16 (1), p. 448. , https://doi.org/10.1186/s12879-016-1787-5, 27562369; Hsieh, Y.H., Middle East respiratory syndrome coronavirus (MERS-CoV) nosocomial outbreak in South Korea: Insights from modeling (2015) Peerj, 3, p. 1505; Nishiura, H., Identifying determinants of heterogeneous transmission dynamics of the Middle East respiratory syndrome (MERS) outbreak in the Republic of Korea, 2015: A retrospective epidemiological analysis (2016) BMJ Open, 6 (2); Chan, R.W., Tropism and replication of Middle East respiratory syndrome coronavirus from dromedary camels in the human respiratory tract: An in-vitro and ex-vivo study (2014) Lancet Respir. Med., 2 (10), pp. 813-822. , https://doi.org/10.1016/S2213-2600(14)70158-4, 25174549; Kucharski, A.J., Althaus, C., The role of superspreading in Middle East respiratory syndrome coronavirus (MERS-CoV) transmission (2015) Eurosurveillance, 20 (25), p. 21167. , https://doi.org/10.2807/1560-7917.es2015.20.25.21167; Chowell, G., Abdirizak, F., Lee, S., Lee, J., Jung, E., Nishiura, H., Viboud, C., Transmission characteristics of MERS and SARS in the healthcare setting: A comparative study (2015) BMC Med, 13 (1); Cotten, M., Spread, circulation, and evolution of the Middle East respiratory syndrome coronavirus (2014) Mbio, 5 (1). , https://doi.org/10.1128/mBio.01062-13; Waters, E.K., Modelling crowding effects in infectious disease transmission (2015) B. Aust. Math. Soc., 92 (3), pp. 522-523; Lloyd, M., Mean crowding (1967) J. Anim. Ecol., pp. 1-30; WHO Mers-Cov Global Summary and Assessment of Risk, , http://www.who.int/emergencies/mers-cov/risk-assessment-july-2017.pdf(2017); Mukandavire, Z., Estimating the reproductive numbers for the 2008–2009 cholera outbreaks in Zimbabwe (2011) Proc. Natl. Acad. Sci. USA, 108 (21), pp. 8767-8772. , https://doi.org/10.1073/pnas.1019712108, 21518855; Johnson, L.R., Phenomenological forecasting of disease incidence using heteroskedastic Gaussian processes: A dengue case study (2018) Ann. Appl. Stat., 12 (1), pp. 27-66; Disease Outbreak News Mers-Cov, , http://www.who.int/csr/don/archive/disease/coronavirus_infections/en/(2018); (2018) Mers-Cov Situation, , http://www.emro.who.int/pandemic-epidemic-diseases/mers-cov/mers-situation-update-july-2018.html; Lin, Q., Chiu, A.P.Y., Zhao, S., He, D., Modeling the spread of Middle East respiratory syndrome coronavirus in Saudi Arabia (2018) Stat Methods Med Res, 27 (7), pp. 1968-1978. , https://doi.org/10.1177/0962280217746442, 29846148","Rodó, X.; ICREA &CLIMA (Climate and Health Program), ISGlobal, Barcelona Institute for Global HealthSpain; email: xavier.rodo@isglobal.org",,Public Library of Science,19352727,,,32059047,English,PLoS. Negl. Trop. Dis.,Article,Final,Open Access,Scopus,2-s2.0-85080833474,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Ok M., Yildiz R., Hatipoglu F., Baspinar N., Ider M., Üney K., Ertürk A., Durgut M.K., Terzi F.",6701698266;15756686000;6602521213;56044654900;57078919700;8408064700;57210173011;57214148414;57196002965;,Use of intestine-related biomarkers for detecting intestinal epithelial damage in neonatal calves with diarrhea,2020,American Journal of Veterinary Research,81,2,,139,146,,,10.2460/ajvr.81.2.139,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078331028&doi=10.2460%2fajvr.81.2.139&partnerID=40&md5=a9aada73f6bae998fcd3580c93d6327d,"Departments of Internal Medicine, Faculty of Veterinary Medicine, University of Selçuk, Konya, 42031, Turkey; Departments of Pathology, Faculty of Veterinary Medicine, University of Selçuk, Konya, 42031, Turkey; Departments of Biochemistry, Faculty of Veterinary Medicine, University of Selçuk, Konya, 42031, Turkey; Departments of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Selçuk, Konya, 42031, Turkey; Department of Internal Medicine, Faculty of Veterinary Medicine, University of Mehmet Akif Ersoy, Burdur, 15030, Turkey; Department of Internal Medicine, Faculty of Veterinary Medicine, University of Mustafa Kemal, Hatay, 31000, Turkey; Department of Pathology, Faculty of Veterinary Medicine, University of Kastamonu, Kastamonu, 37200, Turkey","Ok, M., Departments of Internal Medicine, Faculty of Veterinary Medicine, University of Selçuk, Konya, 42031, Turkey; Yildiz, R., Departments of Pathology, Faculty of Veterinary Medicine, University of Selçuk, Konya, 42031, Turkey; Hatipoglu, F., Departments of Pathology, Faculty of Veterinary Medicine, University of Selçuk, Konya, 42031, Turkey; Baspinar, N., Departments of Biochemistry, Faculty of Veterinary Medicine, University of Selçuk, Konya, 42031, Turkey; Ider, M., Department of Pathology, Faculty of Veterinary Medicine, University of Kastamonu, Kastamonu, 37200, Turkey; Üney, K., Departments of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Selçuk, Konya, 42031, Turkey; Ertürk, A., Department of Internal Medicine, Faculty of Veterinary Medicine, University of Mustafa Kemal, Hatay, 31000, Turkey; Durgut, M.K., Departments of Internal Medicine, Faculty of Veterinary Medicine, University of Selçuk, Konya, 42031, Turkey; Terzi, F., Department of Internal Medicine, Faculty of Veterinary Medicine, University of Mehmet Akif Ersoy, Burdur, 15030, Turkey, Department of Pathology, Faculty of Veterinary Medicine, University of Kastamonu, Kastamonu, 37200, Turkey","OBJECTIVE To evaluate the usefulness of intestinal biomarkers in determining the presence of intestinal epithelial damage in neonatal calves with diarrhea caused by 4 etiologic agents. ANIMALS 40 neonatal calves that were healthy (n = 10) or had diarrhea (30). PROCEDURES The study was a cross-sectional study. Results of hematologic analyses and serum concentrations of intestinal fatty acid–binding protein (I-FABP), liver fatty acid–binding protein (L-FABP), trefoil factor 3 (TFF-3), Claudin-3 (CLDN-3), γ-enteric smooth muscle actin (ACTG2), intestinal alkaline phosphatase (IAP), interleukin-8 (IL-8), platelet-activating factor (PAF), and leptin (LP) were compared among calves grouped according to whether they were healthy (control group; G-1) or had diarrhea caused by K99 Escherichia coli (G-2; n = 10), bovine rota-or coronavirus (G-3; 5 each), or Cryptosporidium spp (G-4; 10). RESULTS Across the 3 time points at which blood samples were obtained and evaluated, the groups of calves with diarrhea generally had markedly higher mean serum concentrations of L-FABP, TFF-3, IAP, IL-8, and LP, compared with the control group. In addition, G-2 also consistently had markedly higher mean serum concentrations of I-FAB and ACTG2 and lower mean serum concentrations of CLDN-3, compared with the control group. CONCLUSIONS AND CLINICAL RELEVANCE Results indicated that degree of intestinal epithelial damage differed among calves grouped by the etiologic agent of diarrhea and that such damage might have been more severe in calves with diarrhea caused by K99 E coli. Additionally, our results indicated that serum concentrations of I-FABP, L-FABP, TFF-3, IAP, IL-8, ACTG2, LP, and CLDN-3 were useful biomarkers of intestinal epithelial damage in calves of the present study. © 2020, American Veterinary Medical Association. All rights reserved.",,alkaline phosphatase; alpha smooth muscle actin; biological marker; claudin 3; fatty acid binding protein; interleukin 8; lactic acid; leptin; potassium; thrombocyte activating factor; trefoil factor 3; alkalosis; animal tissue; Article; autopsy; blood gas analysis; carbon dioxide tension; controlled study; Coronavirinae; Cryptosporidium; diarrhea; enzyme linked immunosorbent assay; epithelium lesion; erythrocyte; Escherichia coli; hematocrit; histology; immunohistochemistry; intestine epithelium; leukocyte; newborn; nonhuman; oxygen saturation; oxygen tension; pH; Rotavirus,"Ok, M., Güler, L., Turgut, K., The studies on the aetiology of diarrhoea in neonatal calves and determination of virulence gene markers of Escherichia coli strains by multiplex PCR (2009) Zoonoses Public Health, 56, pp. 94-101; Sen, I., Altunok, V., Ok, M., EfŞcacy of oral rehydration therapy solutions containing sodium bicarbonate or sodium acetate for treatment of calves with naturally acquired diarrhea, moderate dehydration, and strong ion acidosis (2009) J am Vet Med Assoc, 234, pp. 926-934; Al Mawly, J., Grinberg, A., Prattley, D., Risk factors for neonatal calf diarrhoea and enteropathogen shedding in New Zealand dairy farms (2015) Vet J, 203, pp. 155-160; Björkman, C., Svensson, C., Christensson, B., Cryptosporidium parvum and Giardia intestinalis in calf diarrhoea in Sweden (2003) Acta Vet Scand, 44, pp. 145-152; Furuhashi, M., Hotamisligil, G.S., Fatty acid-binding proteins: Role in metabolic diseases and potential as drug targets (2008) Nat Rev Drug Discov, 7, pp. 489-503; Benkoe, T.M., Mechtler, T.P., Weninger, M., Serum levels of interleukin-8 and gut-associated biomarkers in diagnosing necrotizing enterocolitis in preterm infants (2014) J Pediatr Surg, 49, pp. 1446-1451; Yildiz, R., Ok, M., Ider, M., Evaluation of intestinal damage biomarkers in calves with atresia coli (2018) J Vet Res, 62, pp. 379-384; Derikx, J.P., Bijker, E.M., Vos, G.D., Gut mucosal cell damage in meningococcal sepsis in children: Relation with clinical outcome (2010) Crit Care Med, 38, pp. 133-137; Tuglu, B., Uysal, S., Fatty acid binding proteins (2011) Turk J Biochem, 9, pp. 31-38; Edelson, M.B., Sonnino, R.E., Bagwell, C.E., Plasma intestinal fatty acid binding protein in neonates with necrotizing enterocolitis: A pilot study (1999) J Pediatr Surg, 34, pp. 1453-1457; Guthmann, F., Börchers, T., Wolfrum, C., Plasma concentration of intestinal-and liver-FABP in neonates suffering from necrotizing enterocolitis and in healthy preterm neonates (2002) Mol Cell Biochem, 239, pp. 227-234; Ng, E.W., Poon, T.C., Lam, H.S., Gut-associated biomarkers L-FABP, I-FABP, and TFF3 and LIT score for diagnosis of surgical necrotizing enterocolitis in preterm infants (2013) Ann Surg, 258, pp. 1111-1118; Zhang, B.H., Yu, H.G., Sheng, Z.X., The therapeutic effect of recombinant human trefoil factor 3 on hypoxia-induced necrotizing enterocolitis in immature rat (2003) Regul Pept, 116, pp. 53-60; Goldberg, R.F., Austen, W.G., Jr., Zhang, X., Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition (2008) Proc Natl Acad Sci U S A, 105, pp. 3551-3556; Kampanatkosol, R., Thomson, T., Habeeb, O., The relationship between reticulated platelets, intestinal alkaline phosphatase, and necrotizing enterocolitis (2014) J Pediatr Surg, 49, pp. 273-276; Caplan, M.S., Sun, X.M., Hseuh, W., Role of platelet activating factor and tumor necrosis factor-alpha in neonatal necrotizing enterocolitis (1990) J Pediatr, 116, pp. 960-964; Neu, J., Neonatal necrotizing enterocolitis: An update (2005) Acta Paediatr Suppl, 94, pp. 100-105; Thuijls, G., Derikx, J.P., van Wijck, K., Non-invasive markers for early diagnosis and determination of the severity of necrotizing enterocolitis (2010) Ann Surg, 251, pp. 1174-1180; Evennett, N., Cerigioni, E., Hall, N.J., Smooth muscle actin as a novel serologic marker of severe intestinal damage in rat intestinal ischemia-reperfusion and human necrotising enterocolitis (2014) J Surg Res, 191, pp. 323-330; Woliński, J., Biernat, M., Guilloteau, P., Exogenous leptin controls the development of the small intestine in neonatal piglets (2003) J Endocrinol, 177, pp. 215-222; Hacioglu, A., Algin, C., Pasaoglu, O., Protective effect of leptin against ischemia-reperfusion injury in the rat small intestine (2005) BMC Gastroenterol, 5; Smith, G.W., Treatment of calf diarrhea: Oral fluid therapy (2009) Vet Clin North am Food Anim Pract, 25, pp. 55-72; Luna, L.G., (1968) Manual of Histologic Staining Methods of the Armed Forces Institute of Pathology, pp. 32-39. , 3rd ed. New York: Blakiston Division, McGraw-Hill; Martínez-Moya, P., Ortega-González, M., González, R., Exogenous alkaline phosphatase treatment complements endogenous enzyme protection in colonic inflammation and reduces bacterial translocation in rats (2012) Pharmacol Res, 66, pp. 144-153; Lallès, J.P., Intestinal alkaline phosphatase: Multiple biological roles in maintenance of intestinal homeostasis and modulation by diet (2010) Nutr Rev, 68, pp. 323-332; Lallès, J.P., Intestinal alkaline phosphatase: Novel functions and protective effects (2014) Nutr Rev, 72, pp. 82-94; Ivanov, A.I., Nusrat, A., Parkos, C.A., The epithelium in inflammatory bowel disease: Potential role of endocytosis of junctional proteins in barrier disruption (2004) Novartis Found Symp, 263, pp. 115-124; Zeissig, S., Bürgel, N., Günzel, D., Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn’s disease (2007) Gut, 56, pp. 61-72; Mennigen, R., Nolte, K., Rijcken, E., Probiotic mixture VSL#3 protects the epithelial barrier by maintaining tight junction protein expression and preventing apoptosis in a murine model of colitis (2009) Am J Physiol Gastrointest Liver Physiol, 296, pp. G1140-G1149; Mackendrick, W., Hill, N., Hsueh, W., Increase in plasma platelet-activating factor levels in enterally fed preterm infants (1993) Biol Neonate, 64, pp. 89-95; Martin, C.R., Walker, W.A., Intestinal immune defences and the inflammatory response in necrotising enterocolitis (2006) Semin Fetal Neonatal Med, 11, pp. 369-377; Yildiz, R., Beslek, M., Beydilli, Y., Evaluation of platelet activating factor in neonatal calves with sepsis (2018) J Turk Vet Med Soc, 89, pp. 66-73; Daig, R., Andus, T., Aschenbrenner, E., Increased interleukin 8 expression in the colon mucosa of patients with inflammatory bowel disease (1996) Gut, 38, pp. 216-222; Gaigé, S., Abysique, A., Bouvier, M., Effects of leptin on cat intestinal motility (2003) J Physiol, 546, pp. 267-277; Liu, D.R., Xu, X.J., Yao, S.K., Increased intestinal mucosal leptin levels in patients with diarrhea-predominant irritable bowel syndrome (2018) World J Gastroenterol, 24, pp. 46-57; Semnani, S., Roshandel, G., Keshtkar, A., Serum leptin levels and irritable bowel syndrome: A new hypothesis (2009) J Clin Gastroenterol, 43, pp. 826-830; Jasim, S.M., Abdulkhaleo, H.R., Study of leptin concentrations in children infected with entamoeba histolytica/dispare and Giardia lambia parasites (2015) Mintage J Pharm Med Sci, 4, pp. 9-11; Madan, R., Guo, X., Naylor, C., Role of leptin-mediated colonic inflammation in defense against Clostridium difficile colitis (2014) Infect Immun, 82, pp. 341-349; Kalkanov, I., Dinev, I., Todorova, K., Ultrastructural and immunohistochemical investigations in calves with coronavirus pneumoenteritis syndrome (2018) J Fac Vet Med Kafkas Univ, 24, pp. 791-797; Rondelli, A.L.H., Rondelli, L.A.S., Monteiro, B.R.G., Outbreak of neonatal diarrhea caused by multiple genotypes of rotavirus A in a beef calves herd (2018) Pesqui Vet Bras, 38, pp. 1890-1895; Volynets, V., Rings, A., Bárdos, G., Intestinal barrier analysis by assessment of mucins, tight junctions, and α-defensins in healthy C57BL/6J and BALB/cJ mice (2016) Tissue Barriers, 4","Ok, M.; Departments of Internal Medicine, Faculty of Veterinary Medicine, University of SelçukTurkey; email: mok@selcuk.edu.tr",,American Veterinary Medical Association,29645,,AJVRA,31985285,English,Am. J. Vet. Res.,Article,Final,,Scopus,2-s2.0-85078331028,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Pansri P., Katholm J., Krogh K.M., Aagaard A.K., Schmidt L.M.B., Kudirkiene E., Larsen L.E., Olsen J.E.",57214136624;6506155962;57214977393;57214119946;7401564035;25227646900;57214128823;57204126270;,Evaluation of novel multiplex qPCR assays for diagnosis of pathogens associated with the bovine respiratory disease complex,2020,Veterinary Journal,256,,105425,,,,,10.1016/j.tvjl.2020.105425,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078253504&doi=10.1016%2fj.tvjl.2020.105425&partnerID=40&md5=cdaea6fd2b9a98286f6c790bbcb3a8d9,"DNA Diagnostic, Risskov, Denmark; LVK Veterinary Cattle Practice, Hobro, Denmark; Department of Veterinary and Animal Science, University of Copenhagen, Copenhagen, Denmark; National Veterinary Laboratory, Technical University of Denmark, Lyngby, Denmark","Pansri, P., DNA Diagnostic, Risskov, Denmark; Katholm, J., DNA Diagnostic, Risskov, Denmark; Krogh, K.M., LVK Veterinary Cattle Practice, Hobro, Denmark; Aagaard, A.K., Department of Veterinary and Animal Science, University of Copenhagen, Copenhagen, Denmark; Schmidt, L.M.B., Department of Veterinary and Animal Science, University of Copenhagen, Copenhagen, Denmark; Kudirkiene, E., Department of Veterinary and Animal Science, University of Copenhagen, Copenhagen, Denmark; Larsen, L.E., National Veterinary Laboratory, Technical University of Denmark, Lyngby, Denmark; Olsen, J.E., Department of Veterinary and Animal Science, University of Copenhagen, Copenhagen, Denmark","Bovine respiratory disease complex is the most common disease requiring the use of antimicrobials in industrial calf production worldwide. Pathogenic bacteria (Mannheimia haemolytica (Mh), Pasteurella multocida (Pm), Histophilus somni (Hs), and Mycoplasma bovis) and a range of viruses (bovine respiratory syncytial virus, bovine coronavirus, bovine parainfluenza virus type 3, bovine viral diarrhea virus and bovine herpesvirus type 1) are associated with this complex. As most of these pathogens can be present in healthy and diseased calves, simple detection of their presence in diseased calves carries low predictive value. In other multi-agent diseases of livestock, quantification of pathogens has added substantially to the predictive value of microbiological diagnosis. The aim of this study was to evaluate the ability of two recently developed quantitative PCR (qPCR) kits (Pneumo4B and Pneumo4V) to detect and quantify these bacterial and viral pathogens, respectively. Test efficiencies of the qPCR assays, based on nucleic acid dilution series of target bacteria and viruses, were 93–106% and 91–104%, respectively, with assay detection limits of 10–50 copies of nucleic acids. All 44 strains of target bacteria were correctly identified, with no false positive reactions in 135 strains of non-target bacterial species. Based on standard curves of log10 CFU versus cycle threshold (Ct) values, quantification was possible over a 5-log range of bacteria. In 92 tracheal aspirate samples, the kappa values for agreement between Pneumo4B and bacterial culture were 0.64-0.84 for Mh, Pm and Hs. In an additional 84 tracheal aspirates, agreement between Pneumo4B or Pneumo 4V and certified diagnostic qPCR assays was moderate (0.57) for M. bovis and high (0.71–0.90) for viral pathogens. Thus Pneumo4 kits specifically detected and quantified the relevant pathogens. © 2020 Elsevier Ltd",Bovine respiratory disease; Calf pneumonia; Multiplex qPCR,animal experiment; animal tissue; Article; bacterial strain; bacterium culture; bacterium identification; calf (bovine); cattle disease; controlled study; Histophilus somni; limit of detection; limit of quantitation; Mannheimia haemolytica; multiplex real time polymerase chain reaction; Mycobacterium bovis; nonhuman; Pasteurella multocida; pathogenesis; pneumonia; predictive value; tracheal aspiration procedure,"Albayrak, H., Yazici, Z., Ozan, E., Tamer, C., El, A., Wahed, A., Wehner, S., Weidmann, M., Characterisation of the first bovine parainfluenza virus 3 isolate detected in cattle in Turkey (2019) Vet. Sci., 6, p. 56; Amer, H.M., Abd, E., Wahed, A., Shalaby, M.A., Almajhdi, F.N., Hufert, F.T., Weidmann, M., A new approach for diagnosis of bovine coronavirus using a reverse transcription recombinase polymerase amplification assay (2013) J. Virol. Methods, 193, pp. 337-340; Angen, O., Thomsen, J., Larsen, L.E., Larsen, J., Kokotovic, B., Heegaard, P.M., Enemark, J.M., Respiratory disease in calves: microbiological investigations on trans-tracheally aspirated bronchoalveolar fluid and acute phase protein response (2009) Vet. Microbiol., 137, pp. 165-171; Bell, C.J., Blackburn, P., Elliott, M., Patterson, T.I., Ellison, S., Lahuerta-Marin, A., Ball, H.J., Investigation of polymerase chain reaction assays to improve detection of bacterial involvement in bovine respiratory disease (2014) J. Vet. Diagn. Investig., 26, pp. 631-634; Blodörn, K., Hägglund, S., Gavier-Widen, D., Eléouët, J.-F., Riffault, S., Pringle, J., Taylor, G., Valarcher, J.F., A bovine respiratory syncytial virus model with high clinical expression in calves with specific passive immunity (2015) BMC Vet. Res., 11, p. 76; Bowman, S., Roffey, P., McNevin, D., Gahan, M.E., Evaluation of commercial DNA extraction methods for biosecurity applications (2016) Aust. J. Forensic Sci., 48, pp. 407-420; Buzard, G.S., Baker, D., Wolcott, M.J., Norwood, D.A., Dauphin, L.A., Multi-platform comparison of ten commercial master mixes for probe-based real-time polymerase chain reaction detection of bioterrorism threat agents for surge preparedness (2012) Forensic Sci. Int., 223, pp. 292-297; Cornelissen, J.B., de Bree, F.M., van der Wal, F.J., Kooi, E.A., Koene, M.G., Bossers, A., Smid, B., Wisselink, H.J., Mycoplasma detection by triplex real-time PCR in bronchoalveolar lavage fluid from bovine respiratory disease complex cases (2017) BMC Vet. Res., 13, p. 97; Czuprynski, C.J., Leite, F., Sylte, M., Kuckleburg, C., Schultz, R., Inzana, T., Behling-Kelly, E., Corbeil, L., Complexities of the pathogenesis of Mannheimia haemolytica and Haemophilus somnus infections: challenges and potential opportunities for prevention? (2004) Anim. Health Res. Rev., 5, pp. 277-282; De Briyne, N., Atkinson, J., Pokludova, L., Borriello, S.P., Antibiotics used most commonly to treat animals in Europe (2014) Vet. Rec., 175, p. 325; Dilhari, A., Sampath, A., Gunasekara, C., Fernando, N., Weerasekara, D., Sissons, C., McBain, A., Weerasekera, M., Evaluation of the impact of six different DNA extraction methods for the representation of the microbial community associated with human chronic wound infections using a gel-based DNA profiling method (2017) AMB Express, 7, p. 179; Doyle, D., Credille, B., Lehenbauer, T.W., Berghaus, R., Aly, S.S., Champagne, J., Blanchard, P., Woolums, A., Agreement among four sampling methods to identify respiratory pathogens in dairy calves with acute bovine respiratory disease (2017) J. Vet. Intern. Med., 31, pp. 954-959; Friis, N.F., Krogh, H.V., Isolation of mycoplasmas from Danish cattle (1983) Nord. Vet., 35, pp. 74-81; Fulton, R.W., Bovine respiratory disease research (1983-2009) (2009) Anim. Health Res. Rev., 10, pp. 131-139; Grønbæk, L., Westphael, N., Martin, H.L., Obduktioner kaster lys over årsager til kalvedødelighed (2016) Dansk Veterinærtidsskrifts, 1, pp. 30-33; Hay, K.E., Barnes, T.S., Morton, J.M., Clements, A.C.A., Mahony, T.J., Risk factors for bovine respiratory disease in Australian feedlot cattle: use of a causal diagram-informed approach to estimate effects of animal mixing and movements before feedlot entry (2014) Prev. Vet. Med., 117, pp. 160-169; Howard, C.J., Parsons, K.R., Thomas, L.H., Systemic and local immune responses of gnotobiotic calves to respiratory infection with Mycoplasma bovis (1986) Vet. Immunol. Immunopathol., 11, pp. 291-300; Johnson, K., Burn, C., Wathes, D.C., Rates and risk factors for contagious disease and mortality in young dairy heifers (2011) Cab Rev. Perspect. Agric. Vet. Sci. Nutr. Nat. Resour., 6, p. 1; Johnson, K.F., Chancellor, N., Burn, C.C., Wathes, D.C., Prospective cohort study to assess rates of contagious disease in pre-weaned UK dairy heifers: management practices, passive transfer of immunity and associated calf health (2017) Vet. Rec. Open, 4; Kalle, E., Kubista, M., Rensing, C., Multi-template polymerase chain reaction (2014) Biomol. Detect. Quantif., 2, pp. 11-29; Kishimoto, M., Tsuchiaka, S., Rahpaya, S.S., Hasebe, A., Otsu, K., Sugimura, S., Kobayashi, S., Omatsu, T., Development of a one-run real-time PCR detection system for pathogens associated with bovine respiratory disease complex (2017) J. Vet. Med. Sci., 79, pp. 517-523; Klem, T.B., Sjurseth, S.K., Sviland, S., Gjerset, B., Myrmel, M., Stokstad, M., Bovine respiratory syncytial virus in experimentally exposed and rechallenged calves; viral shedding related to clinical signs and the potential for transmission (2019) BMC Vet. Res., 15, p. 156; Kugadas, A., Poindexter, J., Lee, M.L., Bavananthasivam, J., Call, D.R., Brayton, K.A., Srikumaran, S., Growth of Mannheimia haemolytica: inhibitory agents and putative mechanism of inhibition (2014) Vet. Microbiol., 174, pp. 155-162; Kusiluka, L.J., Kokotovic, B., Ojeniyi, B., Friis, N.F., Ahrens, P., Genetic variations among Mycoplasma bovis strains isolated from Danish cattle (2000) FEMS Microbiol. Lett., 192, pp. 113-118; Landis, J.R., Koch, G.G., The measurement of observer agreement for categorical data (1977) Biometrics, 33, pp. 159-174; Larsen, L.E., Tjornehoj, K., Viuff, B., Jensen, N.E., Uttenthal, A., Diagnosis of enzootic pneumonia in Danish cattle: reverse transcription-polymerase chain reaction assay for detection of bovine respiratory syncytial virus in naturally and experimentally infected cattle (1999) J. Vet. Diagn. Investig., 11, pp. 416-422; Lima, S.F., Teixeira, A.G.V., Higgins, C.H., Lima, F.S., Bicalho, R.C., The upper respiratory tract microbiome and its potential role in bovine respiratory disease and otitis media (2016) Sci. Rep., 6. , 29050; Loy, J.D., Leger, L., Workman, A.M., Clawson, M.L., Bulut, E., Wang, B., Development of a multiplex real-time PCR assay using two thermocycling platforms for detection of major bacterial pathogens associated with bovine respiratory disease complex from clinical samples (2018) J. Vet. Diagn. Investig., 30, pp. 837-847; Mackinnon, A., A spreadsheet for the calculation of comprehensive statistics for the assessment of diagnostic tests and inter-rater agreement (2000) Comput. Biol. Med., 30, pp. 127-134; Nickell, J.S., White, B.J., Metaphylactic antimicrobial therapy for bovine respiratory disease in stocker and feedlot cattle (2010) Vet. Clin. North Am. Food Anim. Pract., 26, pp. 285-301; Pardon, B., Alliet, J., Boone, R., Roelandt, S., Valgaeren, B., Deprez, P., Prediction of respiratory disease and diarrhea in veal calves based on immunoglobulin levels and the serostatus for respiratory pathogens measured at arrival (2015) Prev. Vet. Med., 120, pp. 169-176; Parker, J., Fowler, N., Walmsley, M.L., Schmidt, T., Scharrer, J., Kowaleski, J., Grimes, T., Chen, J., Analytical sensitivity comparison between singleplex real-time PCR and a multiplex PCR platform for detecting respiratory viruses (2015) PLoS One, 10; Payne, S., Methods to Study Viruses. In: Viruses: From Understanding to Investigation (2018), pp. 37-52. , Chapter 4. second edition Academic Press UK and US; Pedersen, K.S., Johansen, M., Angen, O., Jorsal, S.E., Nielsen, J.P., Jensen, T.K., Guedes, R., Baekbo, P., Herd diagnosis of low pathogen diarrhoea in growing pigs - a pilot study (2014) Ir. Vet. J., 67, p. 24; Pedersen, K.S., Stege, H., Jensen, T.K., Guedes, R., Stahl, M., Nielsen, J.P., Hjulsager, C., Angen, O., Diagnostic performance of fecal quantitative real-time polymerase chain reaction for detection of Lawsonia intracellularis-associated proliferative enteropathy in nursery pigs (2013) J. Vet. Diagn. Investig., 25, pp. 336-340; Petersen, M.B., Pedersen, J., Holm, D.L., Denwood, M., Nielsen, L.R., A longitudinal observational study of the dynamics of Mycoplasma bovis antibodies in naturally exposed and diseased dairy cows (2018) J. Dairy Sci., 101, pp. 7383-7396; Rahpaya, S.S., Tsuchiaka, S., Kishimoto, M., Oba, M., Katayama, Y., Nunomura, Y., Kokawa, S., Kirino, Y., Dembo polymerase chain reaction technique for detection of bovine abortion, diarrhea, and respiratory disease complex infectious agents in potential vectors and reservoirs (2018) J. Vet. Sci., 19, pp. 350-357; Richeson, J.T., Beck, P.A., Gadberry, M.S., Gunter, S.A., Hess, T.W., Hubbell, D.S., 3rd, Jones, C., Effects of on-arrival versus delayed modified live virus vaccination on health, performance, and serum infectious bovine rhinotracheitis titers of newly received beef calves (2008) J. Anim. Sci., 86, pp. 999-1005; Shanthalingam, S., Goldy, A., Bavananthasivam, J., Subramaniam, R., Batra, S.A., Kugadas, A., Raghavan, B., Killion, H.J., PCR assay detects Mannheimia haemolytica in culture-negative pneumonic lung tissues of bighorn sheep (Ovis canadensis) from outbreaks in the western USA, 2009-2010 (2014) J. Wildl. Dis., 50, pp. 1-10; Sudaryatma, P.E., Nakamura, K., Mekata, H., Sekiguchi, S., Kubo, M., Kobayashi, I., Subangkit, M., Okabayashi, T., Bovine respiratory syncytial virus infection enhances Pasteurella multocida adherence on respiratory epithelial cells (2018) Vet. Microbiol., 220, pp. 33-38; Svec, D., Tichopad, A., Novosadova, V., Pfaffl, M.W., Kubista, M., How good is a PCR efficiency estimate: recommendations for precise and robust qPCR efficiency assessments (2015) Biomol. Detect. Quantif., 3, pp. 9-16; Tegtmeier, C., Angen, O., Ahrens, P., Comparison of bacterial cultivation, PCR, in situ hybridization and immunohistochemistry as tools for diagnosis of Haemophilus somnus pneumonia in cattle (2000) Vet. Microbiol., 76, pp. 385-394; Tegtmeier, C., Uttenthal, A., Friis, N.F., Jensen, N.E., Jensen, H.E., Pathological and microbiological studies on pneumonic lungs from Danish calves (1999) Zentralblatt Veterinarmedizin Reihe B, 46, pp. 693-700; Timsit, E., Maingourd, C., Dréan, E.L., Belloc, C., Seegers, H., Douart, A., Assié, S., Evaluation of a commercial real-time reverse transcription polymerase chain reaction kit for the diagnosis of bovine respiratory syncytial virus infection (2010) J. Vet. Diagn. Investig., 22, pp. 238-241; Van Driessche, L., Valgaeren, B.R., Gille, L., Boyen, F., Ducatelle, R., Haesebrouck, F., Deprez, P., Pardon, B., A deep nasopharyngeal swab versus nonendoscopic bronchoalveolar lavage for isolation of bacterial pathogens from preweaned calves with respiratory disease (2017) J. Vet. Intern. Med., 31, pp. 946-953; Virtala, A.M., Grohn, Y.T., Mechor, G.D., Erb, H.N., The effect of maternally derived immunoglobulin G on the risk of respiratory disease in heifers during the first 3 months of life (1999) Prev. Vet. Med., 39, pp. 25-37; Wisselink, H.J., Cornelissen, J., van der Wal, F.J., Kooi, E.A., Koene, M.G., Bossers, A., Smid, B., Antonis, A.F.G., Evaluation of a multiplex real-time PCR for detection of four bacterial agents commonly associated with bovine respiratory disease in bronchoalveolar lavage fluid (2017) BMC Vet. Res., 13, p. 221; Zhang, W., Liu, X., Liu, M., Ma, B., Xu, L., Wang, J., Development of a multiplex PCR for simultaneous detection of Pasteurella multocida, Mannheimia haemolytica and Trueperella pyogenes (2017) Acta Vet. Hung., 65, pp. 327-339","Olsen, J.E.; Department of Veterinary and Animal Science, University of CopenhagenDenmark; email: jeo@sund.ku.dk",,Bailliere Tindall Ltd,10900233,,VTJRF,32113583,English,Vet. J.,Article,Final,Open Access,Scopus,2-s2.0-85078253504,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Guan X., Li H., Han M., Jia S., Feng B., Gao X., Wang Z., Jiang Y., Cui W., Wang L., Xu Y.",56642264000;57212388390;57212374542;57193093859;57209145696;57206271409;57208488707;56003035300;57201756492;57193361612;34772167800;,"Epidemiological investigation of feline infectious peritonitis in cats living in Harbin, Northeast China from 2017 to 2019 using a combination of an EvaGreen-based real-time RT-PCR and serum chemistry assays",2020,Molecular and Cellular Probes,49,,101495,,,,,10.1016/j.mcp.2019.101495,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85076533714&doi=10.1016%2fj.mcp.2019.101495&partnerID=40&md5=b09bef55046f96a36226d88fa803df5c,"Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Northeast Agricultural University, Harbin, China; Northeast Science Inspection Station, Key Laboratory of Animal Pathogen Biology of Ministry of Agriculture of China, Harbin, China","Guan, X., Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Northeast Agricultural University, Harbin, China; Li, H., Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Northeast Agricultural University, Harbin, China; Han, M., Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Northeast Agricultural University, Harbin, China; Jia, S., Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Northeast Agricultural University, Harbin, China; Feng, B., Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Northeast Agricultural University, Harbin, China; Gao, X., Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Northeast Agricultural University, Harbin, China; Wang, Z., Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Northeast Agricultural University, Harbin, China; Jiang, Y., Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Northeast Agricultural University, Harbin, China; Cui, W., Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Northeast Agricultural University, Harbin, China; Wang, L., Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Northeast Agricultural University, Harbin, China, Northeast Science Inspection Station, Key Laboratory of Animal Pathogen Biology of Ministry of Agriculture of China, Harbin, China; Xu, Y., Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Northeast Agricultural University, Harbin, China, Northeast Science Inspection Station, Key Laboratory of Animal Pathogen Biology of Ministry of Agriculture of China, Harbin, China","Feline infectious peritonitis (FIP) is caused by the FIP virus (FIPV), a highly virulent mutant form of feline coronavirus (FCoV). This disease is one of the most important infectious diseases in cats, and it is associated with high mortality, particularly among younger cats. In this study, we isolated a wild-type FIPV HRB-17 epidemic strain from the blood sample of household pet cat exhibiting the characteristic wet-form FIP symptoms, which has been confirmed further by animal infection. Further, we developed an EvaGreen-based real-time RT-PCR assay for the accurate detection of FCoV based on the amplification of the highly conserved FIPV N gene. Then, using a combination of the real-time RT-PCR approach and a serum chemistry assay, we performed an epidemiological survey of FIPV infection in cats living in Harbin City, Northeast China. The results indicated that the EvaGreen-based real-time RT-PCR assay can be used for screening FCoV infection in the affected cats at an analytical detection limit of 8.2 × 101 viral genome copies/μL, but could not effectively distinguish FIPVs from FECVs. Additionally, the results of the epidemiological survey investigating feline blood samples (n = 1523) collected between July 2017 to July 2019 revealed an FIPV prevalence of approximately 12% (189/1523). Maybe, the prevalence would be less than 12% due to the real-time RT-PCR assay could not accurately differentiate FIPV and FECV. Nevertheless, it still highlighted the severity of the FIP epidemic in cats and reiterated the urgent need to develop effective anti-FIP therapeutic agents and anti-FIPV vaccines. As pet cats are household animals, risk communication and continuous region-extended surveillance cat programs are recommended. © 2019 Elsevier Ltd",Epidemiological survey; EvaGreen-based real-time RT-PCR; Feline infectious peritonitis virus; Hyperglobulinemia; N gene,genomic RNA; animal experiment; animal model; Article; blood sampling; Canine coronavirus; China; controlled study; feline infectious peritonitis; limit of detection; nonhuman; prevalence; priority journal; real time reverse transcription polymerase chain reaction; RNA extraction; stray cat; virus genome,"Pedersen, N.C., An update on feline infectious peritonitis: virology and immunopathogenesis (2014) Vet. J., 201, pp. 123-132; Kipar, A., Meli, M.L., Feline infectious peritonitis: still an enigma? (2014) Vet. Pathol., 51, pp. 505-526; Holzworth, J.E., Some important disorders of cats (1963) Cornell Vet., 53, pp. 157-160; Ward, J., Morphogenesis of a virus in cats with experimental feline infectious peritonitis (1970) Virology, 41, pp. 191-194; Pedersen, N.C., Boyle, J.F., Floyd, K., Fudge, A., Barker, J., An enteric coronavirus infection of cats and its relationship to feline infectious peritonitis (1981) Am. J. Vet. Res., 42, pp. 368-377; Poland, A.M., Vennema, H., Foley, J.E., Pedersen, N.C., Two related strains of feline infectious peritonitis virus isolated from immunocompromised cats infected with a feline enteric coronavirus (1996) J. Clin. Microbiol., 34, pp. 3180-3184; Vennema, H., Poland, A., Foley, J., Pedersen, N.C., Feline infectious peritonitis viruses arise by mutation from endemic feline enteric coronaviruses (1998) Virology, 243, pp. 150-157; Pedersen, N.C., A review of feline infectious peritonitis virus infection: 1963-2008 (2009) J. Feline Med. Surg., 11, pp. 225-258; Montali, R.J., Strandberg, J.D., Extraperitoneal lesions in feline infectious peritonitis (1972) Vet. Pathol., 9, pp. 109-121; Olsen, C.W., A review of feline infectious peritonitis virus: molecular biology, immunopathogenesis, clinical aspects, and vaccination (1993) Vet. Microbiol., 36, pp. 1-37; Macneill, A.L., Evaluation of available diagnostic techniques for feline infectious peritonitis (2016) Adv. Small Anim. Med. Surg., 29, pp. 1-3; Tsai, H.Y., Chueh, L.L., Lin, C.N., Su, B.L., Clinicopathological findings and disease staging of feline infectious peritonitis: 51 cases from 2003 to 2009 in Taiwan (2011) J. Feline Med. Surg., 13, pp. 74-80; Riemer, F., Kuehner, K.A., Ritz, S., Sauter-Louis, C., Hartmann, K., Clinical and laboratory features of cats with feline infectious peritonitis-a retrospective study of 231 confirmed cases (2000-2010) (2016) J. Feline Med. Surg., 18, pp. 348-356; Pedersen, N.C., Liu, H., Dodd, K.A., Pesavento, P.A., Significance of coronavirus mutants in feces and diseased tissues of cats suffering from feline infectious peritonitis (2009) Viruses, 1, p. 166; Addie, D.D., Jarrett, O., Use of a reverse-transcriptase polymerase chain reaction for monitoring the shedding of feline coronavirus by healthy cats (2001) Vet. Rec., 148, pp. 649-653; Soma, T., Wada, M., Taharaguchi, S., Tajima, T., Detection of ascitic feline coronavirus RNA from cats with clinically suspected feline infectious peritonitis (2014) J. Vet. Med. Sci., 75, pp. 1389-1392; Li, C., Liu, Q., Kong, F., Guo, D., Zhai, J., Su, M., Sun, D., Circulation and genetic diversity of feline coronavirus type I and II from clinically healthy and FIP-suspected cats in China (2019) Transboundary Emerg. Dis., 66, pp. 763-775; Li, X., Scott, F.W., Detection of feline coronaviruses in cell cultures and in fresh and fixed feline tissues using polymerase chain reaction (1994) Vet. Microbiol., 42, p. 65; Charlotte, D., Helps, C.R., Siddell, S.G., Evaluation of real-time RT-PCR for the quantification of FCoV shedding in the faeces of domestic cats (2008) J. Feline Med. Surg., 10, p. 167; Ákos, H., Ádám, B., Farsang, A., Gyula, B., Mikhayil, H., Thomas, B.R., Jonas, B., Sándor, B., Detection of subgenomic mRNA of feline coronavirus by real-time polymerase chain reaction based on primer-probe energy transfer (P-sg-QPCR) (2012) J. Virol. Methods, 181, pp. 155-163; Norris, J.M., Bosward, K.L., White, J.D., Baral, R.M., Catt, M.J., Malik, R., Clinicopathological findings associated with feline infectious peritonitis in Sydney, Australia: 42 cases (1990-2002) (2005) Aust. Vet. J., 83, pp. 666-673; Wang, Y., Feng, B., Niu, C., Jia, S., Sun, C., Wang, Z., Jiang, Y., Xu, Y., Dendritic cell targeting of bovine viral diarrhea virus E2 protein expressed by Lactobacillus casei effectively induces antigen-specific immune responses via oral vaccination (2019) Viruses, 11, p. 575; Gao, X.W., Ma, Y.Y., Wang, Z., Bai, J., Jia, S., Feng, B.H., Jiang, Y.P., Xu, Y.G., Oral immunization of mice with a probiotic Lactobacillus casei constitutively expressing the α-toxoid induces protective immunity against Clostridium perfringens α-toxin (2019) Virulence, 10, pp. 166-179; Pedersen, N.C., Boyle, J.F., Floyd, K., Infection studies in kittens utilizing feline infectious peritonitis virus propagated in cell culture (1981) Am. J. Vet. Res., 42, pp. 363-367; Pedersen, N.C., Floyd, K., Experimental studies with three new strains of feline infectious peritonitis virus FIPVUCD2, FIPV-UCD3, and FIPV-UCD4 (1985) Compend. Contin. Educ. Pract. Vet., 7, pp. 1001-1011; Tasker, S., Diagnosis of feline infectious peritonitis: update on evidence supporting available tests (2018) J. Feline Med. Surg., 20, pp. 228-243","Xu, Y.; Heilongjiang Key Laboratory for Animal Disease Control and Pharmaceutical Development, Northeast Agricultural UniversityChina; email: yigangxu@neau.edu.cn",,Academic Press,8908508,,MCPRE,31846702,English,Mol. Cell. Probes,Article,Final,Open Access,Scopus,2-s2.0-85076533714,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Cong Y., Ulasli M., Schepers H., Mauthe M., V’kovski P., Kriegenburg F., Thiel V., de Haan C.A.M., Reggiori F.",55754660100;35339875800;8596950100;37052411100;57211014159;25225733400;35238592100;7003682643;6602133625;,Nucleocapsid protein recruitment to replication-transcription complexes plays a crucial role in coronaviral life cycle,2020,Journal of Virology,94,4, e01925-19,,,,,10.1128/JVI.01925-19,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078869484&doi=10.1128%2fJVI.01925-19&partnerID=40&md5=c278f9b6831da862816aa2d35fb43aea,"Department of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Department of Cell Biology, University Medical Center Utrecht, Utrecht, Netherlands; Institute of Virology and Immunology, Bern, Switzerland; Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland; Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands","Cong, Y., Department of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Ulasli, M., Department of Cell Biology, University Medical Center Utrecht, Utrecht, Netherlands; Schepers, H., Department of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Mauthe, M., Department of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; V’kovski, P., Institute of Virology and Immunology, Bern, Switzerland, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland; Kriegenburg, F., Department of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Thiel, V., Institute of Virology and Immunology, Bern, Switzerland, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, Bern, Switzerland; de Haan, C.A.M., Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands; Reggiori, F., Department of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, Department of Cell Biology, University Medical Center Utrecht, Utrecht, Netherlands","Coronavirus (CoV) nucleocapsid (N) proteins are key for incorporating genomic RNA into progeny viral particles. In infected cells, N proteins are present at the replication-transcription complexes (RTCs), the sites of CoV RNA synthesis. It has been shown that N proteins are important for viral replication and that the one of mouse hepatitis virus (MHV), a commonly used model CoV, interacts with nonstructural protein 3 (nsp3), a component of the RTCs. These two aspects of the CoV life cycle, however, have not been linked. We found that the MHV N protein binds exclusively to nsp3 and not other RTC components by using a systematic yeast two-hybrid approach, and we identified two distinct regions in the N protein that redundantly mediate this interaction. A selective N protein variant carrying point mutations in these two regions fails to bind nsp3 in vitro, resulting in inhibition of its recruitment to RTCs in vivo. Furthermore, in contrast to the wild-type N protein, this N protein variant impairs the stimulation of genomic RNA and viral mRNA transcription in vivo and in vitro, which in turn leads to impairment of MHV replication and progeny production. Altogether, our results show that N protein recruitment to RTCs, via binding to nsp3, is an essential step in the CoV life cycle because it is critical for optimal viral RNA synthesis. IMPORTANCE CoVs have long been regarded as relatively harmless pathogens for humans. Severe respiratory tract infection outbreaks caused by severe acute respiratory syndrome CoV and Middle East respiratory syndrome CoV, however, have caused high pathogenicity and mortality rates in humans. These outbreaks highlighted the relevance of being able to control CoV infections. We used a model CoV, MHV, to investigate the importance of the recruitment of N protein, a central component of CoV virions, to intracellular platforms where CoVs replicate, transcribe, and translate their genomes. By identifying the principal binding partner at these intracellular platforms and generating a specific mutant, we found that N protein recruitment to these locations is crucial for promoting viral RNA synthesis. Moreover, blocking this recruitment strongly inhibits viral infection. Thus, our results explain an important aspect of the CoV life cycle and reveal an interaction of viral proteins that could be targeted in antiviral therapies. © 2020 American Society for Microbiology. All Rights Reserved.",Coronavirus; Nucleocapsid N protein; Replication-transcription complexes; Viral mRNA synthesis,nonstructural protein 3; nucleocapsid protein; amino acid substitution; amino terminal sequence; animal cell; Article; bacterial cell; carboxy terminal sequence; cell fractionation; controlled study; Coronavirinae; fungal strain; human; human cell; immunofluorescence; in vitro study; in vivo study; life cycle stage; nonhuman; oligomerization; point mutation; priority journal; protein binding; protein interaction; protein phosphorylation; protein structure; RNA synthesis; virus replication; Western blotting,"Cui, J., Li, F., Shi, Z.L., Origin and evolution of pathogenic coronaviruses (2019) Nat Rev Microbiol, 17, pp. 181-192. , https://doi.org/10.1038/s41579-018-0118-9; Perlman, S., Netland, J., Coronaviruses post-SARS: Update on replication and pathogenesis (2009) Nat Rev Microbiol, 7, pp. 439-450. , https://doi.org/10.1038/nrmicro2147; Fehr, A.R., Perlman, S., Coronaviruses: An overview of their replication and pathogenesis (2015) Methods Mol Biol, 1282, pp. 1-23. , https://doi.org/10.1007/978-1-4939-2438-7_1; 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von Brunn, A., Teepe, C., Simpson, J.C., Pepperkok, R., Friedel, C.C., Zimmer, R., Roberts, R., Haas, J., Analysis of intraviral protein-protein interactions of the SARS coronavirus ORFeome (2007) PLoS One, 2. , https://doi.org/10.1371/journal.pone.0000459; de Haan, C.A., Masters, P.S., Shen, X., Weiss, S., Rottier, P.J., The group-specific murine coronavirus genes are not essential, but their deletion, by reverse genetics, is attenuating in the natural host (2002) Virology, 296, pp. 177-189. , https://doi.org/10.1006/viro.2002.1412; Reed, L.J., Muench, H., A simple method of estimating fifty per cent endpoints (1938) Am J Epidemiol, 27, pp. 493-497. , https://doi.org/10.1093/oxfordjournals.aje.a118408; Emery, V.C., Baculovirus expression vectors: Choice of expression vector (1992) Methods Mol Biol, 8, pp. 287-307. , https://doi.org/10.1385/0-89603-191-8:287; Yorimitsu, T., Klionsky, D.J., Atg11 links cargo to the vesicle-forming machinery in the cytoplasm to vacuole targeting pathway (2005) Mol Biol Cell, 16, pp. 1593-1605. , https://doi.org/10.1091/mbc.e04-11-1035; Schwarz, B., Routledge, E., Siddell, S.G., Murine coronavirus nonstructural protein ns2 is not essential for virus replication in transformed cells (1990) J Virol, 64, pp. 4784-4791; Schiller, J.J., Kanjanahaluethai, A., Baker, S.C., Processing of the coronavirus MHV-JHM polymerase polyprotein: Identification of precursors and proteolytic products spanning 400 kilodaltons of ORF1a (1998) Virology, 242, pp. 288-302. , https://doi.org/10.1006/viro.1997.9010; de Haan, C.A., Li, Z., Te Lintelo, E., Bosch, B.J., Haijema, B.J., Rottier, P.J., Murine coronavirus with an extended host range uses heparan sulfate as an entry receptor (2005) J Virol, 79, pp. 14451-14456. , https://doi.org/10.1128/JVI.79.22.14451-14456.2005","Reggiori, F.; Department of Biomedical Sciences of Cells and Systems, University Medical Center Groningen, University of GroningenNetherlands; email: f.m.reggiori@umcg.nl",,American Society for Microbiology,0022538X,,JOVIA,31776274,English,J. Virol.,Article,Final,Open Access,Scopus,2-s2.0-85078869484,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhao X., Chu H., Wong B.H.-Y., Chiu M.C., Wang D., Li C., Liu X., Yang D., Poon V.K.-M., Cai J., Chan J.F.-W., To K.K.-W., Zhou J., Yuen K.-Y.",57190608726;35781456400;7402023413;57201375315;57198729173;56060549800;57214747127;56892956900;54934161900;35557916700;24278817900;14323807300;7405550443;36078079100;,Activation of C-Type Lectin Receptor and (RIG)-I-Like Receptors Contributes to Proinflammatory Response in Middle East Respiratory Syndrome Coronavirus-Infected Macrophages,2020,Journal of Infectious Diseases,221,4,,647,659,,,10.1093/infdis/jiz483,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079020141&doi=10.1093%2finfdis%2fjiz483&partnerID=40&md5=451ccd6c408d2d736857d0234bab9c7c,"State Key Laboratory of Emerging Infectious Diseases, Pokfulam, Hong Kong; Department of Microbiology, Pokfulam, Hong Kong; Carol Yu Centre for Infection, Pokfulam, Hong Kong; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong","Zhao, X., State Key Laboratory of Emerging Infectious Diseases, Pokfulam, Hong Kong, Department of Microbiology, Pokfulam, Hong Kong; Chu, H., State Key Laboratory of Emerging Infectious Diseases, Pokfulam, Hong Kong, Department of Microbiology, Pokfulam, Hong Kong; Wong, B.H.-Y., State Key Laboratory of Emerging Infectious Diseases, Pokfulam, Hong Kong; Chiu, M.C., Department of Microbiology, Pokfulam, Hong Kong; Wang, D., Department of Microbiology, Pokfulam, Hong Kong; Li, C., Department of Microbiology, Pokfulam, Hong Kong; Liu, X., Department of Microbiology, Pokfulam, Hong Kong; Yang, D., Department of Microbiology, Pokfulam, Hong Kong; Poon, V.K.-M., Department of Microbiology, Pokfulam, Hong Kong; Cai, J., Department of Microbiology, Pokfulam, Hong Kong; Chan, J.F.-W., State Key Laboratory of Emerging Infectious Diseases, Pokfulam, Hong Kong, Department of Microbiology, Pokfulam, Hong Kong, Carol Yu Centre for Infection, Pokfulam, Hong Kong, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong; To, K.K.-W., State Key Laboratory of Emerging Infectious Diseases, Pokfulam, Hong Kong, Department of Microbiology, Pokfulam, Hong Kong, Carol Yu Centre for Infection, Pokfulam, Hong Kong, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong; Zhou, J., State Key Laboratory of Emerging Infectious Diseases, Pokfulam, Hong Kong, Department of Microbiology, Pokfulam, Hong Kong; Yuen, K.-Y., State Key Laboratory of Emerging Infectious Diseases, Pokfulam, Hong Kong, Department of Microbiology, Pokfulam, Hong Kong, Carol Yu Centre for Infection, Pokfulam, Hong Kong, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong","Background: Human infection with Middle East respiratory syndrome coronavirus (MERS-CoV) poses an ongoing threat to public health worldwide. The studies of MERS patients with severe disease and experimentally infected animals showed that robust viral replication and intensive proinflammatory response in lung tissues contribute to high pathogenicity of MERS-CoV. We sought to identify pattern recognition receptor (PRR) signaling pathway(s) that mediates the inflammatory cascade in human macrophages upon MERS-CoV infection. Methods: The potential signaling pathways were manipulated individually by pharmacological inhibition, small interfering ribonucleic acid (siRNA) depletion, and antibody blocking. The MERS-CoV-induced proinflammatory response was evaluated by measuring the expression levels of key cytokines and/or chemokines. Reverse transcription-quantitative polymerase chain reaction assay, flow cytometry analysis, and Western blotting were applied to evaluate the activation of related PRRs and engagement of adaptors. Results: MERS-CoV replication significantly upregulated C-type lectin receptor (CLR) macrophage-inducible Ca2+-dependent lectin receptor (Mincle). The role of Mincle for MERS-CoV-triggered cytokine/chemokine induction was established based on the results of antibody blockage, siRNA depletion of Mincle and its adaptor spleen tyrosine kinase (Syk), and Syk pharmacological inhibition. The cytokine and/or chemokine induction was significantly attenuated by siRNA depletion of retinoic acid-inducible-I-like receptors (RLR) or adaptor, indicating that RLR signaling also contributed to MERS-CoV-induced proinflammatory response. Conclusions: The CLR and RLR pathways are activated and contribute to the proinflammatory response in MERS-CoV-infected macrophages. © 2019 The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.",CLR; MERS-CoV; Mincle; proinflammatory response; RLR,C type lectin receptor; lectin receptor; Mincle; pattern recognition receptor; protein kinase Syk; receptor; retinoic acid inducible gene I like receptor; small interfering RNA; unclassified drug; Article; controlled study; cytokine production; enzyme inhibition; human; human cell; inflammation; macrophage; Middle East respiratory syndrome; Middle East respiratory syndrome coronavirus; nonhuman; priority journal; signal transduction; upregulation; virus replication,"Zaki, A.M., Van Boheemen, S., Bestebroer, T.M., Osterhaus, A.D., Fouchier, R.A., Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia (2012) N Engl J Med, 367, pp. 1814-1820; Assiri, A., Al-Tawfiq, J.A., Al-Rabeeah, A.A., Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: A descriptive study (2013) Lancet Infect Dis, 13, pp. 752-761; Guery, B., Poissy, J., El Mansouf, L., (2013) Clinical Features and Viral Diagnosis of Two Cases of Infection with Middle East Respiratory Syndrome Coronavirus: A Report of Nosocomial Transmission. 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Dorhoi, A., Desel, C., Yeremeev, V., The adaptor molecule CARD9 is essential for tuberculosis control (2010) J Exp Med, 207, pp. 777-792; Matsumoto, M., Tanaka, T., Kaisho, T., A novel LPSinducible C-type lectin is a transcriptional target of NF-IL6 in macrophages (1999) J Immunol, 163, pp. 5039-5048; Delaloye, J., Roger, T., Steiner-Tardivel, Q.G., Innate immune sensing of modified vaccinia virus ankara (mva) is mediated by tlr2-tlr6 mda-5 and the nalp3 inflammasome (2009) Plos Pathog, 5, p. e1000480; Ferwerda, G., Kullberg, B.J., De Jong, D.J., Mycobacterium paratuberculosis is recognized by Toll-like receptors and NOD2 (2007) J Leukoc Biol, 82, pp. 1011-1018","Zhou, J.; State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, University of Hong Kong, Queen Mary HospitalHong Kong; email: jiezhou@hku.hk",,Oxford University Press,221899,,JIDIA,31562757,English,J. Infect. Dis.,Article,Final,Open Access,Scopus,2-s2.0-85079020141,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Parry J.,24605791400;,China coronavirus: Hong Kong health staff strike to demand border closure as city records first death,2020,BMJ (Clinical research ed.),368,,,m454,,,,10.1136/bmj.m454,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079002320&doi=10.1136%2fbmj.m454&partnerID=40&md5=02e1635ec002ea43cd433bba17f0e6c4,"Hamilton, Ontario","Parry, J., Hamilton, Ontario",[No abstract available],,,,,,NLM (Medline),17561833,,,32019754,English,BMJ,Article,Final,Open Access,Scopus,2-s2.0-85079002320,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Mahase E.,57208387961;,"China coronavirus should be on ""everybody's agenda,"" says vaccine expert",2020,BMJ (Clinical research ed.),368,,,m476,,,,10.1136/bmj.m476,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079043384&doi=10.1136%2fbmj.m476&partnerID=40&md5=ecdc27a2f4e151294a202e913c435a5e,BMJ,"Mahase, E., BMJ",[No abstract available],,,,,,NLM (Medline),17561833,,,32024634,English,BMJ,Article,Final,Open Access,Scopus,2-s2.0-85079043384,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Mahase E.,57208387961;,Novel coronavirus: Australian GPs raise concerns about shortage of face masks,2020,BMJ (Clinical research ed.),368,,,m477,,,,10.1136/bmj.m477,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079041557&doi=10.1136%2fbmj.m477&partnerID=40&md5=90694c1ffd61b3afab90a38c215eb0be,BMJ,"Mahase, E., BMJ",[No abstract available],,,,,,NLM (Medline),17561833,,,32024636,English,BMJ,Article,Final,Open Access,Scopus,2-s2.0-85079041557,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Gardier S., Petignat D.C.",57200316811;57215218490;,Coronavirus: Stay proactive [Coronavirus: Rester proactif],2020,Revue Medicale Suisse,16,680,,296,,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078959739&partnerID=40&md5=792c947f179f31cbb3e48510b3efac0c,Office du Médecin Cantonal,"Gardier, S.; Petignat, D.C., Office du Médecin Cantonal",[No abstract available],,coronavirus disease 2019; Coronavirus infection; Note; interview,,,,Editions Medecine et Hygiene,16609379,,,32022502,French,Rev. Med. Suisse,Note,Final,,Scopus,2-s2.0-85078959739,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Laconi A., Weerts E.A.W.S., Bloodgood J.C.G., Deniz Marrero J.P., Berends A.J., Cocciolo G., de Wit J.J., Verheije M.H.",55960093400;55981338200;57208211629;57212409188;57194493485;57193340457;7102191226;7801561319;,Attenuated live infectious bronchitis virus QX vaccine disseminates slowly to target organs distant from the site of inoculation,2020,Vaccine,38,6,,1486,1493,,,10.1016/j.vaccine.2019.11.064,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85076605213&doi=10.1016%2fj.vaccine.2019.11.064&partnerID=40&md5=62402131a74e69285f1837dce8624d9a,"Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands; Department of Veterinary Medicine, University of Bari, Valenzano, Italy; GD Animal Health, Deventer, Netherlands","Laconi, A., Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands; Weerts, E.A.W.S., Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands; Bloodgood, J.C.G., Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands; Deniz Marrero, J.P., Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands; Berends, A.J., Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands; Cocciolo, G., Department of Veterinary Medicine, University of Bari, Valenzano, Italy; de Wit, J.J., GD Animal Health, Deventer, Netherlands; Verheije, M.H., Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands","Infectious bronchitis (IB) is a highly contagious respiratory disease of poultry, caused by the avian coronavirus infectious bronchitis virus (IBV). Currently, one of the most relevant genotypes circulating worldwide is IBV-QX (GI-19), for which vaccines have been developed by passaging virulent QX strains in embryonated chicken eggs. Here we explored the attenuated phenotype of a commercially available QX live vaccine, IB Primo QX, in specific pathogens free broilers. At hatch, birds were inoculated with QX vaccine or its virulent progenitor IBV-D388, and postmortem swabs and tissues were collected each day up to eight days post infection to assess viral replication and morphological changes. In the trachea, viral RNA replication and protein expression were comparable in both groups. Both viruses induced morphologically comparable lesions in the trachea, albeit with a short delay in the vaccinated birds. In contrast, in the kidney, QX vaccine viral RNA was nearly absent, which coincided with the lack of any morphological changes in this organ. This was in contrast to high viral RNA titers and abundant lesions in the kidney after IBV D388 infection. Furthermore, QX vaccine showed reduced ability to reach and replicate in conjunctivae and intestines including cloaca, resulting in significantly lower titers and delayed protein expression, respectively. Nephropathogenic IBVs might reach the kidney also via an ascending route from the cloaca, based on our observation that viral RNA was detected in the cloaca one day before detection in the kidney. In the kidney distal tubular segments, collecting ducts and ureter were positive for viral antigen. Taken together, the attenuated phenotype of QX vaccine seems to rely on slower dissemination and lower replication in target tissues other than the site of inoculation. © 2019 The Author(s)",Attenuation; Broilers; Infectious bronchitis virus; Nephropathogenicity; Vaccine; Virulence,avian infectious bronchitis virus vaccine; viral protein; virus antigen; virus RNA; animal experiment; animal model; animal tissue; Article; avian infectious bronchitis; broiler; cloaca; conjunctiva; controlled study; female; immunohistochemistry; intestine; kidney; kidney collecting tubule; kidney distal tubule; male; nonhuman; priority journal; protein expression; trachea; ureter; virus load; virus replication,"Cook, J.K.A., Jackwood, M., Jones, R.C., The long view: 40 years of infectious bronchitis research (2012) Avian Pathol, 41, pp. 239-250; Cavanagh, D., Coronaviridae: a review of coronaviruses and toroviruses 2005:1–54; Valastro, V., Holmes, E.C., Britton, P., Fusaro, A., Jackwood, M.W., Cattoli, G., S1 gene-based phylogeny of infectious bronchitis virus: an attempt to harmonize virus classification (2016) Infect Genet Evol, 39, pp. 349-364; YuDong, W., YongLin, W., ZiChun, Z., GenChe, F., YiHai, J., XiangE, L., Isolation and identification of glandular stomach type IBV (QX IBV) in chickens (1998) Chinese J Anim Quar, 15, p. 1998; Worthington, K.J., Currie, R.J.W., Jones, R.C., A reverse transcriptase-polymerase chain reaction survey of infectious bronchitis virus genotypes in Western Europe from 2002 to 2006 (2008) Avian Pathol, 37, pp. 247-257; Valastro, V., Monne, I., Fasolato, M., Cecchettin, K., Parker, D., Terregino, C., QX-type infectious bronchitis virus in commercial flocks in the UK (2010) Vet Rec, 167, pp. 865-866; Krapež, U., Slavec, B., Rojs, O.Z., Circulation of Infectious Bronchitis Virus Strains from Italy 02 and QX Genotypes in Slovenia Between 2007 and 2009 (2011) Avian Dis Dig, 6, pp. e60-e61; Abro, S.H., Renström, L.H.M., Ullman, K., Belák, S., Baule, C., Characterization and analysis of the full-length genome of a strain of the European QX-like genotype of infectious bronchitis virus (2012) Arch Virol, 157, pp. 1211-1215; de Wit, J.J., Nieuwenhuisen-van Wilgen, J., Hoogkamer, A., vande Sande, H., Zuidam, G.J., Fabri, T.H.F., Induction of cystic oviducts and protection against early challenge with infectious bronchitis virus serotype D388 (genotype QX) by maternally derived antibodies and by early vaccination (2011) Avian Pathol, 40, pp. 463-471; de Wit, J.J., Cazaban, C., Dijkman, R., Ramon, G., Gardin, Y., Detection of different genotypes of infectious bronchitis virus and of infectious bursal disease virus in European broilers during an epidemiological study in 2013 and the consequences for the diagnostic approach (2018) Avian Pathol, 47, pp. 140-151; Jackwood, M.W., Hilt, D.A., Brown, T.P., http://www.jstor.org, Attenuation, Safety, and Efficacy of an Infectious Bronchitis Virus GA98 Serotype Vaccine Author (s): Mark W. Jackwood, Deborah A. Hilt and Thomas P. Brown Published by: American Association of Avian Pathologists Stable 2003;47:627–32. URL:; Gelb, J.J., Cloud, S., Effect of serial embryo passage of an Arkansas-type avian infectious bronchitis virus isolate on clinical response, virus recovery, and immunity (1983) Avian Dis, 27, p. 240; Bijlenga, G., Cook, J.K.A., Gelb, J., De Wit, J.J., Development and use of the H strain of avian infectious bronchitis virus from the Netherlands as a vaccine: a review (2004) Avian Pathol, 33, pp. 550-557; Geerligs, H.J., Tarres-Call, J., Stuurman, B.G.E., Bru, T., Wijmenga, W., Symons, J., Efficacy and safety of an attenuated live QX-like infectious bronchitis virus strain as a vaccine for chickens (2011) Avian Pathol, 40, pp. 93-102; Laconi, A., Berends, A.J., de Laat ECH, Urselmann TAPMP, Verheije HM. Infectious bronchitis virus Mass-type (GI-1) and QX-like (GI-19) genotyping and vaccine differentiation using SYBR green RT-qPCR paired with melting curve analysis (2019) J Virol Methods, 275; Van Beurden, S.J., Berends, A.J., Krämer-Kühl, A., Spekreijse, D., Chénard, G., Philipp, H.C., A reverse genetics system for avian coronavirus infectious bronchitis virus based on targeted RNA recombination (2017) Virol J, 14, pp. 1-13; (2009), Brand JMA Van Den, Kreijtz JHCM, Bodewes R, Stittelaar KJ, Amerongen G Van, Kuiken T, Efficacy of vaccination with different combinations of MF59-adjuvanted and nonadjuvanted seasonal and pandemic influenza vaccines against pandemic H1N1 influenza virus infection in Ferrets 2011;85:2851–8. doi: 10.1128/JVI.01939-10; Hofstad, M.S., Yoder, H.W., Avian infectious bronchitis virus distribution in tissues of chicks (1966) Avian Dis, pp. 230-239; Amarasinghe, A., Abdul-Cader, M.S., Nazir, S., De Silva Senapathi, U., Van Der Meer, F., Cork, S.C., Infectious bronchitis corona virus establishes productive infection in avian macrophages interfering with selected antimicrobial functions (2017) PLoS ONE, 12, pp. 1-21; Reddy, V.R.A.P., Trus, I., Desmarets, L.M.B., Li, Y., Theuns, S., Nauwynck, H.J., Productive replication of nephropathogenic infectious bronchitis virus in peripheral blood monocytic cells, a strategy for viral dissemination and kidney infection in chickens (2016) Vet Res, 47, pp. 1-19; Terregino, C., Toffan, AnnaBeato, M., Serena Beato, M.S., De Nardi, R., Meini, A., Pathogenicity of a QX strain of infectious bronchitis virus in specific pathogen free and commercial broiler chickens, and evaluation of protection induced by a vaccination programme based on the Ma5 and 4/91 serotypes (2008) Avian Pathol, 37, pp. 487-493; Ganapathy, K., Wilkins, M., Forrester, A., Lemiere, S., Cserep, T., McMullin, P., QX-like infectious bronchitis virus isolated from cases of proventriculitis in commercial broilers in England (2012) Vet Rec, 171, p. 597; de Wit, J.J., Sjaak, Cook, J.K.A., Factors influencing the outcome of infectious bronchitis vaccination and challenge experiments (2014) Avian Pathol, 43, pp. 485-497; Dolz, R., Vergara-Alert, J., Pérez, M., Pujols, J., Majò, N., New insights on infectious bronchitis virus pathogenesis: characterization of Italy 02 serotype in chicks and adult hens 2012;156:256–64. doi: 10.1016/j.vetmic.2011.11.001; Benyeda, Z., Szeredi, L., Mató, T., Süveges, T., Balka, G., Abonyi-Tóth, Z., Comparative Histopathology and Immunohistochemistry of QX-like, Massachusetts and 793/B Serotypes of Infectious Bronchitis Virus Infection in Chickens (2010) J Comp Pathol, 143, pp. 276-283; Chen, B.Y., Hosi, S., Nunoya, T., Itakura, C., Histopathology and immunohistochemistry of renal lesions due to infectious bronchitis virus in chicks Histopathology and immunohistochemistry of renal lesions due to infectious bronchitis virus in chicks 2007;9457. doi: 10.1080/03079459608419141; van der Sluis, H.J., Dwars, R.M., Vernooij, J.C.M., Landman, W.J.M., Cloacal reflexes and uptake of fluorescein-labeled polystyrene beads in broiler chickens (2009) Poult Sci, 88, pp. 1242-1249","Verheije, M.H.; Utrecht University, Faculty of Veterinary Medicine, Department of Pathobiology, Yalelaan 1, Netherlands; email: m.h.verheije@uu.nl",,Elsevier Ltd,0264410X,,VACCD,31822427,English,Vaccine,Article,Final,Open Access,Scopus,2-s2.0-85076605213,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, [No author name available],[No author id available],"Calling all coronavirus researchers: keep sharing, stay open",2020,Nature,578,7793,,7,,,1,10.1038/d41586-020-00307-x,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078904394&doi=10.1038%2fd41586-020-00307-x&partnerID=40&md5=7fd5d584a1b611c0693ec7a84fbcea85,,,"As the new coronavirus continues its deadly spread, researchers must ensure that their work on this outbreak is shared rapidly and openly. © 2020, Nature.",Genomics; Health care; Infection; Virology,Coronavirinae; editorial; genomics; nonhuman; virology; animal; bat; Coronavirus infection; epidemic; pneumonia; Coronavirus; Animals; Chiroptera; Coronavirus; Coronavirus Infections; Disease Outbreaks; Pneumonia,,,,Nature Research,280836,,NATUA,32020126,English,Nature,Editorial,Final,Open Access,Scopus,2-s2.0-85078904394,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Jin Y.-H., Cai L., Cheng Z.-S., Cheng H., Deng T., Fan Y.-P., Fang C., Huang D., Huang L.-Q., Huang Q., Han Y., Hu B., Hu F., Li B.-H., Li Y.-R., Liang K., Lin L.-K., Luo L.-S., Ma J., Ma L.-L., Peng Z.-Y., Pan Y.-B., Pan Z.-Y., Ren X.-Q., Sun H.-M., Wang Y., Wang Y.-Y., Weng H., Wei C.-J., Wu D.-F., Xia J., Xiong Y., Xu H.-B., Yao X.-M., Yuan Y.-F., Ye T.-S., Zhang X.-C., Zhang Y.-W., Zhang Y.-G., Zhang H.-M., Zhao Y., Zhao M.-J., Zi H., Zeng X.-T., Wang Y.-Y., Wang X.-H.",56567047800;57214774482;57214753403;57214774992;57204601312;57214775212;57214775774;57215051580;57214776122;57214776215;57214776029;57207150521;57214775675;57203161671;27172163600;57214774852;57214775706;57214775396;57214775364;57208801438;7401790844;36673683600;36182211000;57214775992;57214774486;57214776108;57210421254;56090415300;55626194900;55187802400;57214775819;56537471300;57214776130;57214941712;57214775540;55667630300;57214775515;57214776148;57214775950;57214776544;57214775682;57203163194;57194413053;57197707697;57200054201;57211283467;,A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version),2020,Military Medical Research,7,1,4,,,,7,10.1186/s40779-020-0233-6,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079082102&doi=10.1186%2fs40779-020-0233-6&partnerID=40&md5=52396be752e138a934b55b7edfc0be6d,"Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China; Institute of Hospital Management, Wuhan University, Wuhan, 430071, China; Department of Respiratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China; Department of Pharmacy, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China; Institute of Evidence-Based Medicine and Knowledge Translation, Henan University, Kaifeng, 475000, China; China Academy of Chinese Medical Sciences, Beijing, 100700, China; China Center for Evidence Based Traditional Chinese Medicine (CCEBTCM), Beijing, 100700, China; Department of Critical Care Medicine, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China; Department of Clinical Laboratory, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China; Department of Infectious Diseases, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China; Division of Medical Affairs, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China; Division of Nursing Affairs, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China; Office of Nosocomial Infection Control, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China; Emergency Center, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China; Department of Radiology, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON L8S 4L8, Canada; Department of Traditional Chinese Medicine, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China; Global Health Institute, Wuhan University, Wuhan, 430072, China","Jin, Y.-H., Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China; Cai, L., Institute of Hospital Management, Wuhan University, Wuhan, 430071, China; Cheng, Z.-S., Department of Respiratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China; Cheng, H., Department of Pharmacy, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China; Deng, T., Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China, Institute of Evidence-Based Medicine and Knowledge Translation, Henan University, Kaifeng, 475000, China; Fan, Y.-P., China Academy of Chinese Medical Sciences, Beijing, 100700, China, China Center for Evidence Based Traditional Chinese Medicine (CCEBTCM), Beijing, 100700, China; Fang, C., Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China; Huang, D., Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China; Huang, L.-Q., China Academy of Chinese Medical Sciences, Beijing, 100700, China, China Center for Evidence Based Traditional Chinese Medicine (CCEBTCM), Beijing, 100700, China; Huang, Q., Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China; Han, Y., Institute of Hospital Management, Wuhan University, Wuhan, 430071, China; Hu, B., Department of Critical Care Medicine, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China; Hu, F., Department of Critical Care Medicine, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China; Li, B.-H., Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China, Institute of Evidence-Based Medicine and Knowledge Translation, Henan University, Kaifeng, 475000, China; Li, Y.-R., Department of Clinical Laboratory, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China; Liang, K., Department of Infectious Diseases, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China; Lin, L.-K., Institute of Hospital Management, Wuhan University, Wuhan, 430071, China; Luo, L.-S., Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China; Ma, J., Department of Critical Care Medicine, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China; Ma, L.-L., Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China; Peng, Z.-Y., Department of Critical Care Medicine, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China; Pan, Y.-B., Department of Clinical Laboratory, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China; Pan, Z.-Y., Division of Medical Affairs, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China; Ren, X.-Q., Institute of Evidence-Based Medicine and Knowledge Translation, Henan University, Kaifeng, 475000, China; Sun, H.-M., Division of Nursing Affairs, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China; Wang, Y., Office of Nosocomial Infection Control, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China; Wang, Y.-Y., Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China; Weng, H., Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China; Wei, C.-J., Department of Respiratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China; Wu, D.-F., Department of Pharmacy, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China; Xia, J., Emergency Center, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China; Xiong, Y., Department of Infectious Diseases, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China; Xu, H.-B., Department of Radiology, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China; Yao, X.-M., Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON L8S 4L8, Canada; Yuan, Y.-F., Institute of Hospital Management, Wuhan University, Wuhan, 430071, China; Ye, T.-S., Department of Traditional Chinese Medicine, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China; Zhang, X.-C., Department of Radiology, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China; Zhang, Y.-W., Department of Traditional Chinese Medicine, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China; Zhang, Y.-G., Institute of Hospital Management, Wuhan University, Wuhan, 430071, China; Zhang, H.-M., China Academy of Chinese Medical Sciences, Beijing, 100700, China, China Center for Evidence Based Traditional Chinese Medicine (CCEBTCM), Beijing, 100700, China; Zhao, Y., Emergency Center, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China; Zhao, M.-J., Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China; Zi, H., Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China, Institute of Evidence-Based Medicine and Knowledge Translation, Henan University, Kaifeng, 475000, China; Zeng, X.-T., Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China, Global Health Institute, Wuhan University, Wuhan, 430072, China; Wang, Y.-Y., China Academy of Chinese Medical Sciences, Beijing, 100700, China, China Center for Evidence Based Traditional Chinese Medicine (CCEBTCM), Beijing, 100700, China; Wang, X.-H., Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China, Institute of Hospital Management, Wuhan University, Wuhan, 430071, China","In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province; and then named ""2019 novel coronavirus (2019-nCoV)"" by the World Health Organization (WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world's attention but without treatment and control manual. For the request from frontline clinicians and public health professionals of 2019-nCoV infected pneumonia management, an evidence-based guideline urgently needs to be developed. Therefore, we drafted this guideline according to the rapid advice guidelines methodology and general rules of WHO guideline development; we also added the first-hand management data of Zhongnan Hospital of Wuhan University. This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control (including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. This rapid advice guideline is suitable for the first frontline doctors and nurses, managers of hospitals and healthcare sections, community residents, public health persons, relevant researchers, and all person who are interested in the 2019-nCoV. © 2020 The Author(s).",2019 novel coronavirus; 2019-nCoV; Clinical practice guideline; Evidence-based medicine; Infectious diseases; Pneumonia; Rapid advice guideline; Respiratory disease,"antivirus agent; antiinfective agent; COVID-19; herbaceous agent; severe acute respiratory syndrome coronavirus 2; 2019 novel coronavirus; antiviral therapy; case finding; Chinese medicine; clinical feature; computer assisted tomography; Coronavirinae; coronavirus disease 2019; Coronavirus infection; differential diagnosis; epidemic; evidence based practice; hematological procedure; hospital infection; host; human; incubation time; infection control; infection prevention; mass screening; molecular epidemiology; nonhuman; physical examination; practice guideline; priority journal; prognosis; Review; thorax radiography; travel; virus carrier; virus detection; virus pathogenesis; virus pneumonia; virus transmission; Betacoronavirus; Coronavirus infection; cross infection; diagnostic imaging; evidence based medicine; fluid therapy; infection control; isolation and purification; lung; mass screening; nursing care; pathogenicity; practice guideline; protective equipment; virus pneumonia; Anti-Bacterial Agents; Antiviral Agents; Betacoronavirus; Coronavirus Infections; Cross Infection; Diagnosis, Differential; Drugs, Chinese Herbal; Evidence-Based Medicine; Fluid Therapy; Humans; Infection Control; Lung; Mass Screening; Molecular Epidemiology; Nursing Care; Personal Protective Equipment; Pneumonia, Viral","(2019) WHO Handbook for Guideline Development, 2. , http://apps.who.int/medicinedocs/documents/s22083en/s22083en.pdf, World Health Organization, 2nd ed; Accessed 22 Jan 2020; Norris, S.L., (2013) WHO and Rapid Advice Guidelines: History and Future Directions, , https://g-i-n.net/conference/past-conferences/10th-conference/monday/10-00-am-to-1-00-pm/norris-62.pdf/view, Accessed 22 Jan 2020; Schünemann, H.J., Zhang, Y., Oxman, A.D., Distinguishing opinion from evidence in guidelines (2019) BMJ, 366, p. l4606. , Expert Evidence in Guidelines Group; (2013) GRADE Handbook, , https://gdt.gradepro.org/app/handbook/handbook.html, GRADE working group, Accessed 22 Jan 2020; Guyatt, G.H., Oxman, A.D., Vist, G.E., Kunz, R., Falck-Ytter, Y., Alonso-Coello, P., GRADE: An emerging consensus on rating quality of evidence and strength of recommendations (2008) BMJ., 336 (7650), pp. 924-926; Legault, K., Schunemann, H., Hillis, C., McMaster RARE-Bestpractices clinical practice guideline on diagnosis and management of the catastrophic antiphospholipid syndrome (2018) J Thromb Haemost, 16, pp. 1656-1664; Jin, Y.H., Cai, L., Cheng, Z.S., Cheng, H., Deng, T., Fan, Y.P., A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (Full version) (2020) Yixue Xinzhi, 30 (1), pp. 35-64. , https://doi.org/10.12173/j.issn.1004-5511.2020.01.09, [Article in China]; Jfw, C., Yuan, S., Kok, K.H., Kkt, T., Chu, H.C., Yang, J., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: A study of a family cluster (2020) Lancet, , https://doi.org/10.1016/S0140-6736(20)30154-9; Update on the Epidemic of Novel Coronavirus (2019-nCoV) Infected Pneumonia As at 24:00 on 26 January, , http://www.nhc.gov.cn/xcs/yqfkdt/202001/3882fdcdbfdc4b4fa4e3a829b62d518e.shtml, Health Emergency Office of National Health Commission of the PRC, Accessed 26 Jan 2020; Zhou, P., Yang, X.L., Wang, X.G., Hu, B., Zhang, L., Zhang, W., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature, , https://doi.org/10.1038/s41586-020-2012-7; Perlman, S., Another decade, another coronavirus (2020) N Engl J Med., , https://doi.org/10.1056/NEJMe2001126; (2020) Notice on the Issuance of A Programme for the Diagnosis and Treatment of Novel Coronavirus (2019-nCoV) Infected Pneumonia (Trial Version 4), , http://bgs.satcm.gov.cn/zhengcewenjian/2020-01-28/12576.html, General Office of National Health Committee. Office of State Administration of Traditional Chinese Medicine, Accessed 29 Jan 2020; Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med., , https://doi.org/10.1056/NEJMoa2001017; (2020) Notice on the Issuance of A Program for the Diagnosis and Treatment of Novel Coronavirus (2019-nCoV) Infected Pneumonia (Trial Version 3), , http://www.nhc.gov.cn/xcs/zhengcwj/202001/f492c9153ea9437bb587ce2ffcbee1fa.shtml, General Office of National Health Committee. Office of State Administration of Traditional Chinese Medicine, Accessed 24 Jan 2020; (2020) Information Office to Hold Press Conference on Joint Preventing and Controlling the Epidemic of Novel Coronavirus (2019-nCoV) Infected Pneumonia, , http://www.scio.gov.cn/xwfbh/xwbfbh/wqfbh/42311/42478/index.htm, Information Office of the State Council, Accessed 26 Jan 2020; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, , https://doi.org/10.1016/S0140-6736(20)30183-5; Li, L., Ren, M.J., Zhang, Y.Y., Li, W.Q., Zhao, H.Y., Liang, L.C., Lung CT image of a confirmed case of the 2019 novel coronavirus (2019-nCoV) infected pneumonia (With differential diagnosis of the SARS) (2020) Yixue Xinzhi, 30 (1), pp. 4-6. , [Article in China]; (2020) Program for Prevention and Control of Novel Coronavirus (2019-nCoV) Infected Pneumonia (Trial Version 2), , http://www.nhc.gov.cn/xcs/zhengcwj/202001/c67cfe29ecf1470e8c7fc47d3b751e88.shtml, Disease Control and Prevention Bureau of National Health and Health Commission, Accessed 23 Jan 2020; (2020) Home Care for Patients with Suspected Novel Coronavirus (NCoV) Infection Presenting with Mild Symptoms and Management of Contacts, , https://www.who.int/publications-detail/home-care-for-patients-with-suspected-novel-coronavirus-(ncov)-infection-presenting-with-mild-symptoms-and-management-of-contacts, World Health Organization, Accessed 24 Jan 2020; Kim, J.Y., Song, J.Y., Yoon, Y.K., Choi, S.H., Song, Y.G., Kim, S.R., Middle East respiratory syndrome infection control and prevention guideline for healthcare facilities (2015) Infect Chemother, 47 (4), pp. 278-302; Wang, Y., Lin, L.K., (2020) An Advice Guideline Recommended by Central South Hospital for the Suspected Patients of Novel Coronavirus (2019-nCoV) Infected Pneumonia and Their Close Contactsas at Home Quarantine, , https://mp.weixin.qq.com/s/xFO10WAFB9OUnM7VN92R2w, Accessed 25 Jan 2020; (2020) Infection Prevention and Control during Health Care When Novel Coronavirus (NCoV) Infection Is Suspected, , https://www.who.int/publications-detail/infection-prevention-and-control-during-health-care-when-novel-coronavirus-(ncov)-infection-is-suspected-20200125, World Health Organization, Accessed 26 Jan 2020; (2020) WHO Advice for International Travel and Trade in Relation to the Outbreak of Pneumonia Caused by A New Coronavirus in China, , https://www.who.int/ith/2020-0901_outbreak_of_Pneumonia_caused_by_a_new_coronavirus_in_C/en/, World Health Organization, Accessed 23 Jan 2020; (2020) CDC: Travelers' Health - Novel Coronavirus in China, , https://wwwnc.cdc.gov/travel/notices/watch/novel-coronavirus-china, Centers for Disease Control and Prevention, Accessed 23 Jan 2020; Wang, W., Hu, H., Song, L., Gong, X., Qu, Y., Lu, Z., Image of pulmonary and diagnosis of atypicalnovel coronavirus (2019-nCoV) infected pneumonia: Case series of 14 patients (2020) Yixue Xinzhi, 30 (1), pp. 7-9. , [Article in China]; Chan, K.S., Lai, S.T., Chu, C.M., Tsui, E., Tam, C.Y., Wong, M.M., Treatment of severe acute respiratory syndrome with lopinavir/ritonavir: A multicentre retrospective matched cohort study (2003) Hong Kong Med J, 9 (6), pp. 399-406. , 1:STN:280:DC%2BD3srpsFKhuw%3D%3D 14660806; Chu, C.M., Cheng, V.C., Hung, I.F., Wong, M.M., Chan, K.H., Chan, K.S., Role of lopinavir/ritonavir in the treatment of SARS: Initial virological and clinical findings (2004) Thorax., 59 (3), pp. 252-256. , 1:STN:280:DC%2BD2c%2Fps1anuw%3D%3D; Lai, S.T., Treatment of severe acute respiratory syndrome (2005) Eur J Clin Microbiol Infect Dis, 24 (9), pp. 583-591. , 1:CAS:528:DC%2BD2MXhtFWmtLzM; Brigitte, M., Arti, B., Stephan, A., Judith, A., Bruno, R., Christoph, W., MERS-COV disease associated ARDS -a case report (2015) Crit Care Med, 43 (12), p. 308; Jiang, H., Deng, H., Wang, Y., Liu, Z., Sun, W.M., The possibility of using Lopinave/Litonawe (LPV/r) as treatment for novel coronavirus 2019-nCov pneumonia: A quick systematic review based on earlier coronavirus clinical studies (2020) Zhonghua Jizhen Yixue Zazhi, 29 (2), pp. 182-186. , [Article in China]; Falzarano, D., De Wit, E., Rasmussen, A.L., Feldmann, F., Okumura, A., Scott, D.P., Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques (2013) Nat Med, 19 (10), pp. 1313-1317. , 1:CAS:528:DC%2BC3sXhtl2ktr3J; Chan, J.F., Yao, Y., Yeung, M.L., Deng, W., Bao, L., Jia, L., Treatment with lopinavir/ritonavir or interferon-β1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset (2015) J Infect Dis, 212 (12), pp. 1904-1913. , 1:CAS:528:DC%2BC1cXpsVOqtQ%3D%3D; Omrani, A.S., Saad, M.M., Baig, K., Bahloul, A., Abdul-Matin, M., Alaidaroos, A.Y., Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: A retrospective cohort study (2014) Lancet Infect Dis, 14 (11), pp. 1090-1095. , 1:CAS:528:DC%2BC2cXhs1KltbnL; Khan, P.A., Nousheen, B.B., Maryam, N., Sultana, K., Middle east respiratory syndrome (MERS): A systematic review (2018) Int J Pharm Sci Res, 9 (7), pp. 2616-2625. , 1:CAS:528:DC%2BC1cXit1Kqt7fE; Zhao, Z.W., Zhang, F.C., Xu, M., Huang, K., Zhong, W.N., Cai, W.P., Clinical analysis of 190 cases of outbreak with atypical pneumonia in Guangzhou in spring, 2003 (2003) Zhonghua Yixue Zazhi, 83 (9), pp. 713-718. , 12899744; Meng, Q.H., Dong, P.L., Guo, Y.B., Zhang, K., Liang, L.C., Hou, W., Use of glucocorticoid in treatment of severe acute respiratory syndrome cases (2003) Zhonghua Yufang Yixue Zazhi, 37 (4), pp. 233-235. , 12930669 [Article in China]; Xiao, J.Z., Ma, L., Gao, J., Yang, Z.J., Xing, X.Y., Zhao, H.C., Glucocorticoid-induced diabetes in severe acute respiratory syndrome: The impact of high dosage and duration of methylprednisolone therapy (2004) Zhonghua Neike Zazhi, 43 (3), pp. 179-182. , 15059370 [Article in China]; Ranieri, V.M., Rubenfeld, G.D., Thompson, B.T., Ferguson, N.D., Caldwell, E., Acute respiratory distress syndrome: The Berlin Definition (2012) JAMA., 307 (23), pp. 2526-2533. , ARDS Definition Task Force","Zeng, X.-T.; Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan UniversityChina; email: zengxiantao1128@163.com",,BioMed Central Ltd.,20957467,,,32029004,English,Mil. med. res.,Review,Final,Open Access,Scopus,2-s2.0-85079082102,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, 2019-nCoV National Incident Room Surveillance Team,,"2019-nCoV acute respiratory disease, Australia: Epidemiology Report 1 (Reporting week 26 January - 1 February 2020)",2020,Communicable diseases intelligence (2018),44,,,,,,,10.33321/cdi.2019.44.13,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079080060&doi=10.33321%2fcdi.2019.44.13&partnerID=40&md5=7a4bee7db8a8a67187483869714ece0b,,2019-nCoV National Incident Room Surveillance Team,"This is the first epidemiological report of novel coronavirus (2019-nCoV) acute respiratory disease infections reported in Australia at 19:00 Australian Eastern Daylight Time [AEDT] 1 February 2020. It includes data on Australian cases notified during the week 26 January to 1 February 2020 and in the previous week (19 to 25 January 2020), the international situation and current information on the severity, transmission and spread of the 2019-nCoV infection. © Commonwealth of Australia CC BY-NC-ND.",Australia; case definition; epidemiology; novel coronavirus (2019-nCoV); respiratory disease,"COVID-19; severe acute respiratory syndrome coronavirus 2; Australia; Betacoronavirus; Coronavirus infection; epidemic; human; respiratory tract infection; virus pneumonia; Australia; Betacoronavirus; Coronavirus Infections; Disease Outbreaks; Humans; Pneumonia, Viral; Respiratory Tract Infections",,,,NLM (Medline),22096051,,,32027812,English,Commun Dis Intell (2018),Article,Final,,Scopus,2-s2.0-85079080060,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Mahase E.,57208387961;,Coronavirus: doctor who faced backlash from police after warning of outbreak dies,2020,BMJ (Clinical research ed.),368,,,m528,,,,10.1136/bmj.m528,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079080334&doi=10.1136%2fbmj.m528&partnerID=40&md5=3d81a46ff28b93507331336fae23e528,BMJ,"Mahase, E., BMJ",[No abstract available],,,,,,NLM (Medline),17561833,,,32029435,English,BMJ,Article,Final,Open Access,Scopus,2-s2.0-85079080334,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Patel A., Jernigan D.B., 2019-nCoV CDC Response Team",36139727300;57209456768;,"Initial Public Health Response and Interim Clinical Guidance for the 2019 Novel Coronavirus Outbreak - United States, December 31, 2019-February 4, 2020",2020,MMWR. Morbidity and mortality weekly report,69,5,,140,146,,6,10.15585/mmwr.mm6905e1,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079083658&doi=10.15585%2fmmwr.mm6905e1&partnerID=40&md5=157320727867b4c7dc0ab33bd24d7ae2,CDC,"Patel, A., CDC; Jernigan, D.B., CDC; 2019-nCoV CDC Response Team","On December 31, 2019, Chinese health officials reported a cluster of cases of acute respiratory illness in persons associated with the Hunan seafood and animal market in the city of Wuhan, Hubei Province, in central China. On January 7, 2020, Chinese health officials confirmed that a novel coronavirus (2019-nCoV) was associated with this initial cluster (1). As of February 4, 2020, a total of 20,471 confirmed cases, including 2,788 (13.6%) with severe illness,* and 425 deaths (2.1%) had been reported by the National Health Commission of China (2). Cases have also been reported in 26 locations outside of mainland China, including documentation of some person-to-person transmission and one death (2). As of February 4, 11 cases had been reported in the United States. On January 30, the World Health Organization (WHO) Director-General declared that the 2019-nCoV outbreak constitutes a Public Health Emergency of International Concern.† On January 31, the U.S. Department of Health and Human Services (HHS) Secretary declared a U.S. public health emergency to respond to 2019-nCoV.§ Also on January 31, the president of the United States signed a ""Proclamation on Suspension of Entry as Immigrants and Nonimmigrants of Persons who Pose a Risk of Transmitting 2019 Novel Coronavirus,"" which limits entry into the United States of persons who traveled to mainland China to U.S. citizens and lawful permanent residents and their families (3). CDC, multiple other federal agencies, state and local health departments, and other partners are implementing aggressive measures to slow transmission of 2019-nCoV in the United States (4,5). These measures require the identification of cases and their contacts in the United States and the appropriate assessment and care of travelers arriving from mainland China to the United States. These measures are being implemented in anticipation of additional 2019-nCoV cases in the United States. Although these measures might not prevent the eventual establishment of ongoing, widespread transmission of the virus in the United States, they are being implemented to 1) slow the spread of illness; 2) provide time to better prepare health care systems and the general public to be ready if widespread transmission with substantial associated illness occurs; and 3) better characterize 2019-nCoV infection to guide public health recommendations and the development of medical countermeasures including diagnostics, therapeutics, and vaccines. Public health authorities are monitoring the situation closely. As more is learned about this novel virus and this outbreak, CDC will rapidly incorporate new knowledge into guidance for action by CDC and state and local health departments.",,"Wuhan coronavirus; adult; aged; Betacoronavirus; Coronavirus infection; epidemic; female; human; infection control; isolation and purification; laboratory; male; middle aged; practice guideline; public health service; United States; virology; Adult; Aged; Betacoronavirus; Centers for Disease Control and Prevention, U.S.; Coronavirus Infections; Disease Outbreaks; Female; Humans; Infection Control; Laboratories; Male; Middle Aged; Practice Guidelines as Topic; Public Health Practice; United States",,,,NLM (Medline),1545861X,,,32027631,English,MMWR Morb. Mortal. Wkly. Rep.,Article,Final,Open Access,Scopus,2-s2.0-85079083658,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Zarocostas J.,6603420677;,What next for the coronavirus response?,2020,"Lancet (London, England)",395,10222,,401,,,,10.1016/S0140-6736(20)30292-0,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079107341&doi=10.1016%2fS0140-6736%2820%2930292-0&partnerID=40&md5=37e64edbe77531272b2d0aecea566bdc,,"Zarocostas, J.",[No abstract available],,severe acute respiratory syndrome coronavirus 2; Betacoronavirus; Coronavirus infection; global health; human; international cooperation; World Health Organization; Betacoronavirus; Coronavirus Infections; Global Health; Humans; International Cooperation; World Health Organization,,,,NLM (Medline),1474547X,,,32035538,English,Lancet,Note,Final,Open Access,Scopus,2-s2.0-85079107341,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, [No author name available],[No author id available],China bans sale of wildlife following coronavirus,2020,Veterinary Record,186,5,,144,145,,,10.1136/vr.m495,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079080644&doi=10.1136%2fvr.m495&partnerID=40&md5=5c8e49e0b0a5ea442120fe7dc611544b,,,[No abstract available],,animal welfare; China; commercial phenomena; Coronavirinae; Coronavirus infection; epidemic; government; illegal wildlife trade; law enforcement; nonhuman; Note; public policy; safety; wildlife conservation; article; China; Coronavirinae; wildlife,,,,British Veterinary Association,424900,,VETRA,32029660,English,Vet. Rec.,Note,Final,Open Access,Scopus,2-s2.0-85079080644,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Yin S., Zhang M.",57215932264;56461604200;,New coronavirus pneumonia and outbreak epidemic virus and eye disease [暴发性流行性疾病病毒传播途径与眼病],2020,Zhonghua Shiyan Yanke Zazhi/Chinese Journal of Experimental Ophthalmology,38,2,,156,160,,,10.3760/cma.j.issn.2095-0160.2020.02.014,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082421927&doi=10.3760%2fcma.j.issn.2095-0160.2020.02.014&partnerID=40&md5=ebdf2e8c0ce2696cdded769867a7f904,"Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Shantou, 515041, China","Yin, S., Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Shantou, 515041, China; Zhang, M., Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Shantou, 515041, China","Since the outbreak of the new coronavirus pneumonia (NCP) in Wuhan City, China, the main transmission mode as well as the diagnosis and treatment of NCP have become a focus of research in China and World Health Organization.Understanding the mode of infection, transmission and biological behavior of the novel coronavirus (2019-nCoV) is undoubtedly a key of cutting off the spread and prevention of the disease which doctors are fearing to be a worldwide epidemic.In February 2020, Lancet published a correspondence paper, which reviewed a case of NCP patient who first started with conjunctivitis, and raised the issue that the transmission of 2019-nCoV through the ocular surface must not be ignored, causing widespread concern.However, due to a lack of clinical observation data and laboratory research at present, the relationship between NCP pathogen infection and ocular surface infection is not completely clear.So far, there have been many studies and reports on the observation of large-scale epidemic virus infections and eye diseases.This article reviews the eye performance of various types of epidemic virus infections and provides a reference for NCP prevention and control. Copyright © 2020 by the Chinese Medical Association.",Epidemic; Eye disease; Infection; Novel coronavirus; Pneumonia; Virus,,"Li, Q., Guan, X., Wu, P., Early transmission dynamics in wuhan,china,of novel coronavirus-infected pneumonia (2020) New Eng J Med, , https://www.nejm.org/doi/full/10.1056/NEJMoa2001316?query=featured_home, [2020-02-05]; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan,China (2020) Lancet, , https://doi.org/10.1016/S0140-6736(20)30183-5, [2020-02-05]; Belser, J.A., Rota, P.A., Tumpey, T.M., Ocular tropism of respiratory viruses (2013) Microbiol Mol Biol Rev, 77 (1), pp. 144-156; Khairallah, M., Kahloun, R., Ocular manifestations of emerging infectious diseases (2013) Curr Opin Ophthalmol, 24 (6), pp. 574-580; Olofsson, S., Kumlin, U., Dimock, K., Avian influenza and sialic acid receptors:more than meets the eye (2005) Lancet Infect Dis, 5 (3), pp. 184-188; Chentoufi, A.A., Dasgupta, G., Nesburn, A.B., Nasolacrimal duct closure modulates ocular mucosal and systemic CD4+ T-cell responses induced following topical ocular or intranasal immunization (2010) Clin Vaccine Immunol, 17 (3), pp. 342-353; 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Somkijrungroj, T., Kongwattananon, W., Ocular manifestations of dengue (2019) Curr Opin Ophthalmol, 30 (6), pp. 500-505; DaSilva, P.A.N., Ito, C.R.M., Barbosa, M.S., Arboviruses (chikungunya,dengue,and Zika) associated with ophthalmic changes:a focus on aqueous fluid and vitreous humor (2019) Eur J Clin Microbiol Infect Dis, pp. 1-7. , https://link.springer.com/article/10.1007%2Fs10096-019-03792-9, [2020-02-05]; Oliver, G.F., Carr, J.M., Smith, J.R., Emerging infectious uveitis:Chikungunya,dengue,Zika and Ebola:A review (2019) Clin Exp Ophthalmol, 47 (3), pp. 372-380; Teoh, S.C., Chee, C.K., Laude, A., Optical coherence tomography patterns as predictors of visual outcome in dengue-related maculopathy (2010) Retina, 30 (3), pp. 390-398; Murray, K.O., Walker, C., Gould, E., The virology,epidemiology,and clinical impact of West Nile virus:a decade of advancements in research since its introduction into the Western Hemisphere (2011) Epidemiol Infect, 139 (6), pp. 807-817; Colpitts, T.M., Conway, M.J., Montgomery, R.R., West Nile Virus:biology,transmission,and human infection (2012) Clin Microbiol Rev, 25 (4), pp. 635-648; Khairallah, M., Ben, Y.S., Ladjimi, A., Chorioretinal involvement in patients with West Nile virus infection (2004) Ophthalmology, 111 (11), pp. 2065-2070; Oliver, G.F., Carr, J.M., Smith, J.R., Emerging infectious uveitis:Chikungunya,dengue,Zika and Ebola:A review (2019) Clin Exp Ophthalmol, 47 (3), pp. 372-380; Agahan, A.L., Torres, J., Fuentes-Páez, G., Intraocular inflammation as the main manifestation of Rickettsia conorii infection (2011) Clin Ophthalmol, 5, pp. 1401-1407; Mahendradas, P., Avadhani, K., Shetty, R., Chikungunya and the eye:a review (2013) J Ophthalmic Inflamm Infect, 3 (1), p. 35. , https://www.ncbi.nlm.nih.gov/pubmed/23514031; Duffy, M.R., Chen, T.H., Hancock, W.T., Zika virus outbreak on Yap Island,Federated States of Micronesia (2009) N Engl J Med, 360 (24), pp. 2536-2543; Cerbino-Neto, J., Mesquita, E.C., Souza, T.M., Clinical manifestations of Zika virus infection,Rio de Janeiro,Brazil,2015 (2016) Emerg Infect Dis, 22 (7), pp. 1318-1320; Sneller, M.C., Reilly, C., Badio, M., A longitudinal study of Ebola sequelae in Liberia (2019) N Engl J Med, 380 (10), pp. 924-934; Bwaka, M.A., Bonnet, M.J., Calain, P., Ebola hemorrhagic fever in Kikwit,Democratic Republic of the Congo:clinical observations in 103 patients (1999) J Infect Dis, 179, pp. S1-S7; Forrester, J.V., Ebola virus and persistent chronic infection:when does replication cease (2018) Ann Transl Med, 6, p. S39; Varkey, J.B., Shantha, J.G., Crozier, I., Persistence of Ebola virus in ocular fluid during convalescence (2015) N Engl J Med, 372 (25), pp. 2423-2427; Lu, R., Zhao, X., Li, J., Genomic characterisation and epidemiology of 2019 novel coronavirus:implications for virus origins and receptor binding (2020) Lancet, , https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30251-8/fulltext, [2020-02-04]; Imai, Y., Kuba, K., Ohto-Nakanishi, T., Angiotensin-converting enzyme 2 (ACE2) in disease pathogenesis (2010) Circ J, 74 (3), pp. 405-410","Zhang, M.; Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong KongChina; email: zmz@jsiec.org",,Henan Institute of Ophthalmology,20950160,,,,Chinese,Zhonghua Shiyan Yanke Zazhi Chin. J. Exp. Ophthalmol.,Review,Final,,Scopus,2-s2.0-85082421927,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Kim J.Y., Choe P.G., Oh Y., Oh K.J., Kim J., Park S.J., Park J.H., Na H.K., Oh M.-D.",57211142178;15070608400;57214775150;57214774729;57214776379;57214775336;57214775755;57214774064;7201600302;,"The first case of 2019 novel coronavirus pneumonia imported into korea from wuhan, china: Implication for infection prevention and control measures",2020,Journal of Korean Medical Science,35,5, e61,,,,10,10.3346/jkms.2020.35.e61,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079080346&doi=10.3346%2fjkms.2020.35.e61&partnerID=40&md5=c4833263d2da0fe48cc636f48088a23c,"Department of Internal Medicine, Incheon Medical Center, Incheon, South Korea; Infection Control Office, Incheon Medical Center, Incheon, South Korea; Designated Isolation Unit, Incheon Medical Center, Incheon, South Korea; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea; Department of Radiology, Incheon Medical Center, Incheon, South Korea","Kim, J.Y., Department of Internal Medicine, Incheon Medical Center, Incheon, South Korea, Infection Control Office, Incheon Medical Center, Incheon, South Korea, Designated Isolation Unit, Incheon Medical Center, Incheon, South Korea; Choe, P.G., Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea; Oh, Y., Department of Internal Medicine, Incheon Medical Center, Incheon, South Korea; Oh, K.J., Department of Radiology, Incheon Medical Center, Incheon, South Korea; Kim, J., Infection Control Office, Incheon Medical Center, Incheon, South Korea; Park, S.J., Infection Control Office, Incheon Medical Center, Incheon, South Korea; Park, J.H., Infection Control Office, Incheon Medical Center, Incheon, South Korea; Na, H.K., Designated Isolation Unit, Incheon Medical Center, Incheon, South Korea; Oh, M.-D., Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea","In December 2019, a viral pneumonia outbreak caused by a novel betacoronavirus, the 2019 novel coronavirus (2019-nCoV), began in Wuhan, China. We report the epidemiological and clinical features of the first patient with 2019-nCoV pneumonia imported into Korea from Wuhan. This report suggests that in the early phase of 2019-nCoV pneumonia, chest radiography would miss patients with pneumonia and highlights taking travel history is of paramount importance for early detection and isolation of 2019-nCoV cases. © 2020 The Korean Academy of Medical Sciences.",2019-nCoV; Coronavirus; Outbreak; Pneumonia; Radiography,"COVID-19; adult; anamnesis; case report; China; Coronavirus infection; diagnostic imaging; epidemic; female; human; lung; pathology; South Korea; thorax radiography; travel; virus pneumonia; Adult; China; Coronavirus Infections; Disease Outbreaks; Female; Humans; Lung; Medical History Taking; Pneumonia, Viral; Radiography, Thoracic; Republic of Korea; Travel","Channappanavar, R., Perlman, S., Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology (2017) Semin Immunopathol, 39 (5), pp. 529-539; Corman, V.M., Muth, D., Niemeyer, D., Drosten, C., Hosts and sources of endemic human coronaviruses (2018) Adv Virus Res, 100, pp. 163-188; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet. Forthcoming; Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., A novel coronavirus from patients with Pneumonia in China, 2019 (2020) N Engl J Med. Forthcoming; Novel Coronavirus (2019-nCoV) situation report-12 https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports, Updated 2020. Accessed February 2, 2020; Hale, M.J., Hoskins, R.S., Baker, M.G., Screening for influenza A(H1N1)pdm09, Auckland International Airport, New Zealand (2012) Emerg Infect Dis, 18 (5), pp. 866-868; Kang, C.K., Song, K.H., Choe, P.G., Park, W.B., Bang, J.H., Kim, E.S., Clinical and epidemiologic characteristics of spreaders of middle east respiratory syndrome coronavirus during the 2015 outbreak in Korea (2017) J Korean Med Sci, 32 (5), pp. 744-749; Kim, E.S., Choe, P.G., Park, W.B., Oh, H.S., Kim, E.J., Nam, E.Y., Clinical progression and cytokine profiles of middle east respiratory syndrome coronavirus infection (2016) J Korean Med Sci, 31 (11), pp. 1717-1725; Rothe, C., Schunk, M., Sothmann, P., Bretzel, G., Froeschl, G., Wallrauch, C., Transmission of 2019-nCoV infection from an asymptomatic contact in Germany (2020) N Engl J Med. Forthcoming","Oh, M.; Department of Internal Medicine, Seoul National University College of Medicine, 103 Daehak-ro Jongno-gu, South Korea; email: mdohmd@snu.ac.kr",,Korean Academy of Medical Science,10118934,,JKMSE,32030925,English,J. Korean Med. Sci.,Article,Final,Open Access,Scopus,2-s2.0-85079080346,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Mahase E.,57208387961;,"Coronavirus: NHS staff get power to keep patients in isolation as UK declares ""serious threat""",2020,BMJ (Clinical research ed.),368,,,m550,,,,10.1136/bmj.m550,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079238137&doi=10.1136%2fbmj.m550&partnerID=40&md5=a8344c3efb27bacb2d2863193bc25ef6,BMJ,"Mahase, E., BMJ",[No abstract available],,,,,,NLM (Medline),17561833,,,32041792,English,BMJ,Article,Final,,Scopus,2-s2.0-85079238137,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Mahase E.,57208387961;,"Coronavirus: global stocks of protective gear are depleted, with demand at ""100 times"" normal level, WHO warns",2020,BMJ (Clinical research ed.),368,,,m543,,,,10.1136/bmj.m543,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079217305&doi=10.1136%2fbmj.m543&partnerID=40&md5=4ec41b2b9837af97528f794b0eac8805,BMJ,"Mahase, E., BMJ",[No abstract available],,,,,,NLM (Medline),17561833,,,32041691,English,BMJ,Article,Final,Open Access,Scopus,2-s2.0-85079217305,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Yoo J.-H., Hong S.-T.",7402295435;57204538103;,The outbreak cases with the novel coronavirus suggest upgraded quarantine and isolation in Korea,2020,Journal of Korean Medical Science,35,5, e62,,,,1,10.3346/jkms.2020.35.e62,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079084303&doi=10.3346%2fjkms.2020.35.e62&partnerID=40&md5=77f62b4a2d43037ee4737a21b1a48586,"Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea; Department of Internal Medicine, Bucheon St. Mary's Hospital, Bucheon, South Korea; Department of Tropical Medicine and Parasitology, Seoul National University College of Medicine, Seoul, South Korea","Yoo, J.-H., Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea, Department of Internal Medicine, Bucheon St. Mary's Hospital, Bucheon, South Korea; Hong, S.-T., Department of Tropical Medicine and Parasitology, Seoul National University College of Medicine, Seoul, South Korea",[No abstract available],,"COVID-19; adult; complication; Coronavirus infection; diagnostic imaging; epidemic; female; health care policy; human; lung; male; middle aged; migration; patient isolation; quarantine; South Korea; virus pneumonia; young adult; Adult; Coronavirus Infections; Disease Outbreaks; Emigration and Immigration; Female; Health Policy; Humans; Lung; Male; Middle Aged; Patient Isolation; Pneumonia, Viral; Quarantine; Republic of Korea; Young Adult","Statement on the second meeting of the International Health Regulations (2005) Emergency Committee regarding the outbreak of novel coronavirus (2019-nCoV) https://www.who.int/news-room/detail/30-01-2020-statement-on-the-second-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-outbreak-of-novel-coronavirus-(2019-ncov), Updated 2020. Accessed January 31, 2020; Kim, J.Y., Choe, P.G., Oh, Y., Oh, K.J., Kim, J., Park, S.J., The first case of 2019 novel coronavirus pneumonia imported into Korea from Wuhan, China: implication for infection prevention and control measures (2020) J Korean Med Sci, 35 (5), p. e61; Yoo, J.H., The fight against the 2019-nCoV outbreak: an arduous March has just begun (2020) J Korean Med Sci, 35 (4), p. e56; Munster, V.J., Koopmans, M., van Doremalen, N., van Riel, D., de Wit, E., A novel coronavirus emerging in China - key questions for impact assessment (2020) N Engl J Med. Forthcoming; Gensini, G.F., Yacoub, M.H., Conti, A.A., The concept of quarantine in history: from plague to SARS (2004) J Infect, 49 (4), pp. 257-261; Tognotti, E., Lessons from the history of quarantine, from plague to influenza A (2013) Emerg Infect Dis, 19 (2), pp. 254-259","Hong, S.; Department of Tropical Medicine and Parasitology, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, South Korea; email: hst@snu.ac.kr",,Korean Academy of Medical Science,10118934,,JKMSE,32030926,English,J. Korean Med. Sci.,Editorial,Final,Open Access,Scopus,2-s2.0-85079084303,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wei X., She G., Wu T., Xue C., Cao Y.",57193958241;57214820178;57214822505;24400445400;36039272800;,"PEDV enters cells through clathrin-, caveolae-, and lipid raft-mediated endocytosis and traffics via the endo-/lysosome pathway",2020,Veterinary Research,51,1,10,,,,1,10.1186/s13567-020-0739-7,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079212095&doi=10.1186%2fs13567-020-0739-7&partnerID=40&md5=e00b15da4885f1c6c2409f0839b3df11,"State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510006, China","Wei, X., State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510006, China; She, G., State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510006, China; Wu, T., State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510006, China; Xue, C., State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510006, China; Cao, Y., State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510006, China","With the emergence of highly pathogenic variant strains, porcine epidemic diarrhea virus (PEDV) has led to significant economic loss in the global swine industry. Many studies have described how coronaviruses enter cells, but information on PEDV invasion strategies remains insufficient. Given that the differences in gene sequences and pathogenicity between classical and mutant strains of PEDV may lead to diverse invasion mechanisms, this study focused on the cellular entry pathways and cellular transport of the PEDV GI and GII subtype strains in Vero cells and IPEC-J2 cells. We first characterized the kinetics of PEDV entry into cells and found that the highest invasion rate of PEDV was approximately 33% in the IPEC-J2 cells and approximately 100% in the Vero cells. To clarify the specific endocytic pathways, systematic research methods were used and showed that PEDV enters cells via the clathrin- and caveolae-mediated endocytosis pathways, in which dynamin II, clathrin heavy chain, Eps15, cholesterol, and caveolin-1 were indispensably involved. In addition, lipid raft extraction assay showed that PEDV can also enter cells through lipid raft-mediated endocytosis. To investigate the trafficking of internalized PEDV, we found that PEDV entry into cells relied on low pH and internalized virions reached lysosomes through the early endosome-late endosome-lysosome pathway. The results concretely revealed the entry mechanisms of PEDV and provided an insightful theoretical basis for the further understanding of PEDV pathogenesis and guidance for new targets of antiviral drugs. © 2020 The Author(s).",,,"Chasey, D., Cartwright, S.F., Virus-like particles associated with porcine epidemic diarrhoea (1978) Res Vet Sci, 25, pp. 255-256. , 1:STN:280:DyaE1M%2Fns1SgtQ%3D%3D 103154 103154; Jung, K., Saif, L.J., Porcine epidemic diarrhea virus infection: Etiology, epidemiology, pathogenesis and immunoprophylaxis (2015) Vet J, 204, pp. 134-143. , 25841898 25841898; Lee, C., Porcine epidemic diarrhea virus: An emerging and re-emerging epizootic swine virus (2015) Virol J, 12, p. 193. , 26689811 4687282 1:CAS:528:DC%2BC28XitVKitLjE; Song, D., Moon, H., Kang, B., Porcine epidemic diarrhea: A review of current epidemiology and available vaccines (2015) Clin Exp Vaccine Res, 4, pp. 166-176. , 26273575 4524901; Song, D., Park, B., Porcine epidemic diarrhoea virus: A comprehensive review of molecular epidemiology, diagnosis, and vaccines (2012) Virus Genes, 44, pp. 167-175. , 1:CAS:528:DC%2BC38XivVynu7g%3D 22270324 22270324; 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Li, L., Fu, F., Guo, S., Wang, H., He, X., Xue, M., Yin, L., Liu, P., Porcine intestinal enteroids: A new model for studying enteric coronavirus porcine epidemic diarrhea virus infection and the host innate response (2019) J Virol, 93, pp. e01682-e01718. , 30541861 6384061; Liu, C., Ma, Y.M., Yang, Y., Zheng, Y., Shang, J., Zhou, Y.S., Jiang, S.B., Li, F., Cell entry of porcine epidemic diarrhea coronavirus is activated by lysosomal proteases (2016) J Biol Chem, 291, pp. 24779-24786. , 1:CAS:528:DC%2BC28XhvV2gu77L 27729455 5114425","Xue, C.; State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen UniversityChina; email: xuecy@mail.sysu.edu.cn",,BioMed Central Ltd.,9284249,,VEREE,32041637,English,Vet. Res.,Article,Final,Open Access,Scopus,2-s2.0-85079212095,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "He F.-Y., Deng K.-W., Pan X., Zhou Y.-Q.",12241046100;12241555800;57210072589;55762072500;,Research strategy of drugs against 2019-novel coronavirus based on supramolecular “qi chromatography” theory of TCM [基于中医药超分子“气析”理论探讨抗新型冠状病毒药物的研究策略],2020,Chinese Traditional and Herbal Drugs,51,3,,557,562,,,10.7501/j.issn.0253-2670.2020.03.001,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082312107&doi=10.7501%2fj.issn.0253-2670.2020.03.001&partnerID=40&md5=d6f6fff9861206b73d3f352af1a19303,"College of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China; Hunan Key laboratory of Druggability and Preparation Modification of TCM, Changsha, 410208, China; Laboratory of Processing and Pharmaceutical Preparation Engineering Technology of TCM, Hunan University of Chinese Medicine, Changsha, 410208, China; The First Clinical Hospital of TCM, Hunan University of Chinese Medicine, Changsha, 410007, China; Laboratory of Supramolecular Mechanism and Mathematic-Physics Characterization for Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha, 410208, China; Key Laboratory of Property and Pharmacodynamics of TCM, State Administration of Traditional Chinese Medicine, Changsha, 410208, China","He, F.-Y., College of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China, Hunan Key laboratory of Druggability and Preparation Modification of TCM, Changsha, 410208, China, Laboratory of Processing and Pharmaceutical Preparation Engineering Technology of TCM, Hunan University of Chinese Medicine, Changsha, 410208, China, Laboratory of Supramolecular Mechanism and Mathematic-Physics Characterization for Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha, 410208, China, Key Laboratory of Property and Pharmacodynamics of TCM, State Administration of Traditional Chinese Medicine, Changsha, 410208, China; Deng, K.-W., Hunan Key laboratory of Druggability and Preparation Modification of TCM, Changsha, 410208, China, The First Clinical Hospital of TCM, Hunan University of Chinese Medicine, Changsha, 410007, China; Pan, X., College of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China, Hunan Key laboratory of Druggability and Preparation Modification of TCM, Changsha, 410208, China, Laboratory of Supramolecular Mechanism and Mathematic-Physics Characterization for Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha, 410208, China, Key Laboratory of Property and Pharmacodynamics of TCM, State Administration of Traditional Chinese Medicine, Changsha, 410208, China; Zhou, Y.-Q., College of Pharmacy, Hunan University of Chinese Medicine, Changsha, 410208, China, Hunan Key laboratory of Druggability and Preparation Modification of TCM, Changsha, 410208, China, Laboratory of Processing and Pharmaceutical Preparation Engineering Technology of TCM, Hunan University of Chinese Medicine, Changsha, 410208, China, Key Laboratory of Property and Pharmacodynamics of TCM, State Administration of Traditional Chinese Medicine, Changsha, 410208, China","At present, the 2019-novel coronavirus (2019-nCoV) is rampant all over the country, and controlling the spread of its epidemic has become a top priority. It is very difficult to control the epidemic spreading because there is no specific drug to fight against it. Therefore, it is urgent task for us to develop a specific drug as soon as possible, and attracting worldwide attention. The studies on anti-2019-nCoV drugs were generally carried out in three modes, as vaccine, chemical drugs and traditional Chinese medicine (TCM). Because the developing on vaccines and chemicals takes too long, it is hard to solve the urgent problem. Moreover, the RNA of coronavirus has been recombined so quickly that the vaccines and drugs studied with great efforts not only may miss the epidemic time, but also cannot be used in the next generation of new coronavirus treatment, as a result that the work of epidemic prevention is formidable. However, the prescriptions from traditional Chinese medicine theory can cure the epidemic disease, but how to develop it into a specific drug with clear chemical composition and clear pharmacologic mechanism, is also an urgent problem to be solved. In this paper, the new coronavirus and its drug development are reviewed, while the advantages and disadvantages are analyzed, and the drug dilemma research phenomenon is clarified by using the supramolecular “qi chromatography” theory. It is suggested that the strategy of anti-coronavirus drug developing should be put forward based on the impact of “qi chromatography” of biological supramolecular “imprinting template”, in order to develop new drugs against 2019-nCoV to control the spread of the epidemic as quick as we can, and establish a new research and development model of anti-coronavirus drug on integration of traditional Chinese and Western medicine, turning passive into active. © 2020, Editorial Office of Chinese Traditional and Herbal Drugs. All right reserved.",2019-novel coronavirus (2019-nCoV); Epidemic situation; Imprinting template; Modernization of traditional Chinese medicine; Qi chromatography; Supermolecule; Traditional Chinese medicine theory,,"孙淑芳, 王媛媛, 刘陆世, 等. 冠状病毒概述 [J]. 中国动物检疫, 2013, 30(6): 68-71; 王 欢, 丁 铲, 廖 瑛. 冠状病毒入胞途径的研究进展 [J]. 病毒学报, 2019, 35(6): 964-971; https://doi.org/10.13344/j.microbiol.china, 谢春芳, 于瑞嵩, 董世娟, 等. 冠状病毒感染调控细胞凋亡机制研究进展 [J/OL]. 微生物学通报 [2020-02-02]; 李广兴, 潘 龙. 冠状病毒基因组结构和相关蛋白研究进展 [J]. 东北农业大学学报, 2013, 44(9): 149-154; 新冠状病毒侵入宿主细胞机制研究获进展 [J]. 微生物学通报, 2013, 40(8): 1486; 田国保, 董建平, 张 璐, 等. 新型冠状病毒感染研究进展 [J]. 中华实验和临床感染病杂志: 电子版, 2013, 7(4): 126-128; 杨 扬, 谭文杰. 冠状病毒载体研究进展 [J]. 病毒学报, 2012, 28(3): 297-302; 易波, 曹明华. SARS流行病学及预防控制研究进展 [J]. 海峡预防医学杂志, 2008, 14(1): 30-32; Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) New Engl J Med; Phelan, A.L., Katz, R., Gostin, L.O., The novel coronavirus originating in Wuhan, China: Challenges for Global Health Governance (2020) JAMA; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet; Chan, J.F., Yuan, S., Kok, K.H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: A study of a family cluster (2020) Lancet; Wang, C., Horby, P.W., Hayden, F.G., A novel coronavirus outbreak of global health concern (2020) Lancet; 龙厚玉, 严有望. SARS疫苗的研究现状和挑战 [J]. 预防医学论坛, 2007, 13(1): 56-59; 陈执中. 新型冠状病毒及其防治药物研究进展 [J]. 食品与药品, 2014, 16(2): 147-149; 牛培华, 谭文杰. 中东呼吸综合征抗病毒治疗研究进展 [J]. 病毒学报, 2018, 34(5): 599-605; 陈顺达, 杨 洋, 郭洁茹. 中东呼吸综合征治疗药物研究进展 [J]. 药物流行病学杂志, 2016, 25(9): 586-590; 孙国根. 我国研发出抗MERS病毒药物 [N]. 健康报, 2015-06-16(002); 邓杨梅, 张水娟, 陈季强, 等. 可用于SARS治疗的抗病毒药物 [J]. 世界临床药物, 2005, 26(1): 11-15; Leung, P.C., The efficacy of Chinese medicine for SARS: A review of Chinese publications after the crisis (2007) Am J Chin Med, 35 (4), pp. 575-581; 李致重. SARS防治的中医理性之思 [J]. 辽宁中医杂志, 2004, 31(10): 799-802; 易文龙. 双黄连, 鱼腥草, 大蒜新素注射液抗鼠冠状病毒MHV-3效应的体内外实验研究 [D]. 武汉: 华中科技大学, 2006; 鲁晏武, 孟庆海, 陈仁寿, 等. 治疗疫病内服方剂用药规律数据挖掘 [J]. 时珍国医国药, 2018, 29(6): 1490-1492; 张稚鲲. 疫病(急性传染性疾病)古今用药特点及配伍规律研究 [D]. 南京: 南京中医药大学, 2017; https://doi.org/10.16368/j.issn.1674-8999.2020.02.000, 周铭心. 从五运六气辨识与防治新型冠状病毒感染所致肺炎 [J/OL]. 中医学报 [2020-02-02]; http://kns.cnki.net/kcms/detail/11.2166.R.20200129.1258.002.html, 王玉光, 齐文升, 马家驹, 等. 新型冠状病毒(2019-nCoV)肺炎中医临床特征与辨证治疗初探 [J/OL]. 中医杂志 [2020-02-02]; 孙 立. 抗戾饮对呼吸道冠状病毒感染模型影响的实验研究 [D]. 广州: 广州中医药大学, 2006; http://kns.cnki, 靳英辉, 蔡林, 程真顺, 等. 新型冠状病毒(2019-nCoV)感染的肺炎诊疗快速建议指南(标准版) [J/OL]. 解放军医学杂志 [2020-02-02]; 贺福元, 贺 红, 邓凯文, 等. 超分子""印迹模板""(药素)特征的中药药理学研究方法探索 [J]. 中国中药杂志, 2015, 40(21): 4313-4318; 贺 鹏, 李海英, 樊启猛, 等. 超分子""印迹模板""理论解析中药五味 [J]. 中草药, 2019, 50(12): 2763-2770; 贺福元, 周逸群, 邓凯文, 等. 超分子化学对中医药理论的特殊影响 [J]. 中国中药杂志, 2014, 39(8): 1534-1543",,,Editorial Office of Chinese Traditional and Herbal Drugs,2532670,,,,Chinese,Chin. Trad. Herbal Drugs,Article,Final,,Scopus,2-s2.0-85082312107,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, COVID-19 National Incident Room Surveillance Team,,"COVID-19, Australia: Epidemiology Report 2 (Reporting week ending 19:00 AEDT 8 February 2020)",2020,Communicable diseases intelligence (2018),44,,,,,,,10.33321/cdi.2020.44.14,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079932856&doi=10.33321%2fcdi.2020.44.14&partnerID=40&md5=885b7e173e55d26f7d82ca50bac41c49,,COVID-19 National Incident Room Surveillance Team,"This is the second epidemiological report for coronavirus disease (COVID-19), previously known as novel coronavirus (2019-nCoV), reported in Australia as at 19:00 Australian Eastern Daylight Time [AEDT] 8 February 2020. It includes data on Australian cases notified during the week ending 19:00 AEDT 8 February 2020, the international situation and current information on the severity, transmission and spread of the COVID-19 infection. © Commonwealth of Australia CC BY-NC-ND.",2019-nCoV; acute respiratory disease; Australia; case definition; COVID-19; epidemiology; novel coronavirus,"COVID-19; severe acute respiratory syndrome coronavirus 2; Australia; Betacoronavirus; Coronavirus infection; epidemic; human; virus pneumonia; Australia; Betacoronavirus; Coronavirus Infections; Disease Outbreaks; Humans; Pneumonia, Viral",,,,NLM (Medline),22096051,,,32050080,English,Commun Dis Intell (2018),Article,Final,Open Access,Scopus,2-s2.0-85079932856,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Matter M.,57215116680;,Novel coronavirus (2019-nCoV): Lessons of uncertainty and globalization [2019-NCoV: Leçons d'incertitudes et de mondialisation],2020,Revue Medicale Suisse,16,681,,340,,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079338695&partnerID=40&md5=39a466802112c6432f6cbebe074ce854,"AMGe, Rue Micheli-du Crest 12, Genève, 1205, Switzerland","Matter, M., AMGe, Rue Micheli-du Crest 12, Genève, 1205, Switzerland",[No abstract available],,2019 novel coronavirus; Coronavirinae; Note,,"Matter, M.; AMGe, Rue Micheli-du Crest 12, Switzerland; email: michel.matter@amge.ch",,Editions Medecine et Hygiene,16609379,,,32049463,French,Rev. Med. Suisse,Note,Final,,Scopus,2-s2.0-85079338695,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Nau J.-Y.,55708087600;,"Coronavirus: Dr. Li Wenliang, whistleblower, hero and martyr [Coronavirus: Dr Li Wenliang, lanceur d'alerte, héros et martyr]",2020,Revue Medicale Suisse,16,681,,336,337,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079335322&partnerID=40&md5=4863f4618c4d56f9752ac998c7d7a3c6,,"Nau, J.-Y.",[No abstract available],,Coronavirinae; human; medical research; nonhuman; Note; virus transmission,"Lemaître, F., Leplâtre, S., Emotion En Chine À L'Annonce De La Mort Du Docteur Li Wenliang, Lanceur D'Alerte Sur Le Coronavirus Le Monde, , 6 février. 2020","Nau, J.-Y.email: jeanyves.nau@gmail.com",,Editions Medecine et Hygiene,16609379,,,32049461,French,Rev. Med. Suisse,Note,Final,,Scopus,2-s2.0-85079335322,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Mahase E.,57208387961;,"Coronavirus: online GP bookings should be stopped because of safety risks, warns BMA",2020,BMJ (Clinical research ed.),368,,,m611,,,,10.1136/bmj.m611,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079337704&doi=10.1136%2fbmj.m611&partnerID=40&md5=d851dda60ab8946ea5051d0129c3bf5e,BMJ,"Mahase, E., BMJ",[No abstract available],,,,,,NLM (Medline),17561833,,,32054601,English,BMJ,Article,Final,Open Access,Scopus,2-s2.0-85079337704,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Ribeiro J., Bingre P., Strubbe D., Reino L.",55432218000;57208626583;57214868044;55893475900;,Coronavirus: why a permanent ban on wildlife trade might not work in China,2020,Nature,578,7794,,217,,,,10.1038/d41586-020-00377-x,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079336721&doi=10.1038%2fd41586-020-00377-x&partnerID=40&md5=66b0107fee3e2cb56157ee56c57a9e95,,"Ribeiro, J.; Bingre, P.; Strubbe, D.; Reino, L.",[No abstract available],Diseases; Society,,,,,Nature Research,280836,,NATUA,32047312,English,Nature,Note,Final,Open Access,Scopus,2-s2.0-85079336721,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Wood C.,7403538663;,"Infections without borders: A new coronavirus in Wuhan, China",2020,British Journal of Nursing,29,3,,166,167,,,10.12968/bjon.2020.29.3.166,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079336210&doi=10.12968%2fbjon.2020.29.3.166&partnerID=40&md5=19ea5ee9d1b0db856ec0e79a1a745f21,"Birmingham City University, United Kingdom","Wood, C., Birmingham City University, United Kingdom",[No abstract available],,severe acute respiratory syndrome coronavirus 2; Betacoronavirus; China; Coronavirus infection; epidemic; global health; human; isolation and purification; travel related disease; virology; Betacoronavirus; China; Coronavirus Infections; Disease Outbreaks; Global Health; Humans; Travel-Related Illness,"Boland, M., O'Riordan, M., Preparedness and management of global public health threats at points of entry in Ireland and the EU in the context of a potential Brexit (2019) Global Health., 15, p. 53; Chan, J.F.W., Yuan, S., Kok, K.H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: A study of a family cluster (2020) Lancet., 24. , January; (2020) Coronavirus: Latest Information and Advice, , https://tinyurl.com/syds3y4, Department of Health and Social Care, Public Health England, (accessed 4 January 2020); Pneumonia cases possibly associated with a novel coronavirus in Wuhan, China (2020) Risk Assessment, , https://tinyurl.com/t23899z, European Centre for Disease Prevention and Control, 9 January, (accessed 4 February 2020); (2020) Novel Coronavirus (Wuhan, China) Infection, , https://tinyurl.com/s9qs6ol, Fitfortravel (Travel and International Health Team of Health Protection Scotland), (accessed 4 February 2020); Huang, C.L., Wang, Y.M., Li, X.W., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet., 24. , January; Lu, H., Stratton, C.W., Tang, Y.W., Outbreak of pneumonia of unknown etiology in Wuhan China: The mystery and the miracle (2020) J Med Virol., 16. , January; Mahase, E., China coronavirus: WHO declares international emergency as death toll exceeds 200 (2020) BMJ., 368, p. m408; Wilson, M.E., The traveler and emerging infections: Sentinel, courier, transmitter (2003) J Appl Microbiol., 94, pp. 1S-11S; (2015) World Health Organization Best Practices for the Naming of New Human Infectious Diseases, , https://tinyurl.com/sgqzt5k, World Health Organization, (accessed 4 February 2020); (2016) International Health Regulations (2005) 3rd Edn., , https://www.who.int/ihr/publications/9789241580496/en/, World Health Organization, (accessed 4 February 2020); (2020) Novel Coronavirus (2019-nCoV): Situation Report 10, , https://tinyurl.com/rhryhe7, World Health Organization, 30 January, (accessed 4 February 2020); (2020) Statement on the Meeting of the International Health Regulations (2005) Emergency Committee Regarding the Outbreak of Novel Coronavirus (2019-nCoV), , https://tinyurl.com/v8ulkhf, World Health Organization, 23 January, (accessed 4 February 2020); (2020) Statement on the Second Meeting of the International Health Regulations (2005) Emergency Committee Regarding the Outbreak of Novel Coronavirus (2019-nCoV), , https://tinyurl.com/rjdtx2k, World Health Organization. 30 January, (accessed 4 February 2020)","Wood, C.; Birmingham City UniversityUnited Kingdom; email: cate.wood@bcu.ac.uk",,MA Healthcare Ltd,9660461,,,32053437,English,Brit. J. Nurs.,Note,Final,Open Access,Scopus,2-s2.0-85079336210,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, [No author name available],[No author id available],"As coronavirus spreads, the time to think about the next epidemic is now",2020,Nature,578,7794,,191,,,,10.1038/d41586-020-00379-9,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079335202&doi=10.1038%2fd41586-020-00379-9&partnerID=40&md5=ffb25cd7ed05e4649065da0ab9c050dc,,,"World leaders and international donors must strengthen the most vulnerable nations’ health-care systems. [Figure not available: see fulltext.]. © 2020, Nature.",Developing world; Health care; Infection; Virology,Coronavirus,,,,Nature Research,280836,,NATUA,32047314,English,Nature,Editorial,Final,Open Access,Scopus,2-s2.0-85079335202,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Bhadelia N.,16645011200;,Coronavirus: hospitals must learn from past pandemics,2020,Nature,578,7794,,193,,,1,10.1038/d41586-020-00354-4,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079334104&doi=10.1038%2fd41586-020-00354-4&partnerID=40&md5=163f00f7b800074499bd9c225269307a,,"Bhadelia, N.","Use techniques honed during the SARS, H1N1 and Ebola epidemics to separate sick and well, keep workers safe and prepare for the next outbreak, says Nahid Bhadelia [Figure not available: see fulltext.] © 2020, Nature.",Health care; Infection; Virology,"2019 novel coronavirus; body fluid; Coronavirinae; Coronavirus infection; coughing; decontamination; disease transmission; Ebola hemorrhagic fever; hand washing; health care facility; health care personnel; health care policy; health care quality; human; infection control; infection risk; influenza A (H1N1); intensive care; measles; nonhuman; Note; pandemic; patient care; personnel shortage; priority journal; sample size; severe acute respiratory syndrome; sneezing; travel; tuberculosis; virus particle; Coronavirus infection; influenza; Influenza A virus (H1N1); New York; tertiary care center; Coronavirus; Coronavirus; Coronavirus Infections; Health Personnel; Humans; Influenza A Virus, H1N1 Subtype; Influenza, Human; New York City; Tertiary Care Centers",,"Bhadelia, N.email: nbhadeli@bu.edu",,Nature Research,280836,,NATUA,32047315,English,Nature,Note,Final,Open Access,Scopus,2-s2.0-85079334104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Nazareth R., Chasqueira M.-J., Rodrigues M.-L., Paulino C., Conceição C., Lêdo L., Segura Ú., Santos M., Messias A., Póvoa P., Paixão P.",44061957000;34876247400;23395262500;57215730176;57064000400;57215134997;57190794284;54585948300;57215466301;6602772147;6508103792;,Respiratory viruses in mechanically ventilated patients: A pilot study,2020,BMC Pulmonary Medicine,20,1,39,,,,,10.1186/s12890-020-1082-5,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079339566&doi=10.1186%2fs12890-020-1082-5&partnerID=40&md5=9c6dab75fa94256f790c67558a4f6300,"Hospital Beatriz Ângelo, Avenida Carlos Teixeira 3, Loures, 2674-514, Portugal; Centro de Estudos de Doenças Crónicas, CEDOC, Faculdade de Ciências Médicas, NOVA Medical School, Campo Mártires da Pátria, 130, Lisbon, 1169-056, Portugal; Hospital São Francisco de Xavier, Estrada Forte Do Alto Duque, Lisbon, 1449-005, Portugal; Hospital Curry Cabral, Centro Hospitalar de Lisboa Central, Rua da Beneficiência n° 8, Lisbon, 1069-166, Portugal; Center for Clinical Epidemiology, Research Unit of Clinical Epidemiology, OUH, Odense University Hospital, Odense, Denmark; Clinical Pathology Laboratory (Synlab), Hospital da Luz, Av Lusíada, 100, Lisbon, 1500-650, Portugal","Nazareth, R., Hospital Beatriz Ângelo, Avenida Carlos Teixeira 3, Loures, 2674-514, Portugal, Centro de Estudos de Doenças Crónicas, CEDOC, Faculdade de Ciências Médicas, NOVA Medical School, Campo Mártires da Pátria, 130, Lisbon, 1169-056, Portugal; Chasqueira, M.-J., Centro de Estudos de Doenças Crónicas, CEDOC, Faculdade de Ciências Médicas, NOVA Medical School, Campo Mártires da Pátria, 130, Lisbon, 1169-056, Portugal; Rodrigues, M.-L., Centro de Estudos de Doenças Crónicas, CEDOC, Faculdade de Ciências Médicas, NOVA Medical School, Campo Mártires da Pátria, 130, Lisbon, 1169-056, Portugal; Paulino, C., Hospital São Francisco de Xavier, Estrada Forte Do Alto Duque, Lisbon, 1449-005, Portugal; Conceição, C., Hospital São Francisco de Xavier, Estrada Forte Do Alto Duque, Lisbon, 1449-005, Portugal; Lêdo, L., Hospital São Francisco de Xavier, Estrada Forte Do Alto Duque, Lisbon, 1449-005, Portugal; Segura, Ú., Hospital Beatriz Ângelo, Avenida Carlos Teixeira 3, Loures, 2674-514, Portugal; Santos, M., Hospital Curry Cabral, Centro Hospitalar de Lisboa Central, Rua da Beneficiência n° 8, Lisbon, 1069-166, Portugal; Messias, A., Hospital Beatriz Ângelo, Avenida Carlos Teixeira 3, Loures, 2674-514, Portugal; Póvoa, P., Centro de Estudos de Doenças Crónicas, CEDOC, Faculdade de Ciências Médicas, NOVA Medical School, Campo Mártires da Pátria, 130, Lisbon, 1169-056, Portugal, Hospital São Francisco de Xavier, Estrada Forte Do Alto Duque, Lisbon, 1449-005, Portugal, Center for Clinical Epidemiology, Research Unit of Clinical Epidemiology, OUH, Odense University Hospital, Odense, Denmark; Paixão, P., Centro de Estudos de Doenças Crónicas, CEDOC, Faculdade de Ciências Médicas, NOVA Medical School, Campo Mártires da Pátria, 130, Lisbon, 1169-056, Portugal, Clinical Pathology Laboratory (Synlab), Hospital da Luz, Av Lusíada, 100, Lisbon, 1500-650, Portugal","Background: Respiratory virome is an integral part of the human microbiome and its characterization may contribute to a better understanding of the changes that arise in the disease and, consequently, influence the approach and treatment of patients with acute lower respiratory infections. The aim of this study was to evaluate the presence of respiratory viruses in the lower airways of individuals undergoing invasive mechanical ventilation, with and without acute lower respiratory infection (respectively WRI and WORI groups). Methods: We studied 44 mini-bronchoalveolar lavage samples (collected with a double catheter, Combicath® kit) from patients with mean age in the seventh decade, 20 from WORI group and 24 from WRI group, who were hospitalized for acute respiratory failure in Intensive Care Units of two hospitals in the Lisbon area. Real-time PCR was applied to verify analyse the presence of 15 common respiratory viruses (adenovirus, human bocavirus, influenza virus A and B, repiratory syncytial virus, human parainfluenza virus types 1, 2, 3 and 4, human enterovirus, human rhinovirus, human metapneumovirus, human coronavirus group 1 (229E, NL63) and 2 (OC43, HKU1). Results: Respiratory viruses were detected in six of the 20 patients in the WORI group: influenza AH3 (n = 2), parainfluenza virus 1/3 (n = 2), human rhinovirus (n = 2), respiratory syncytial virus (n = 1) and human metapneumovirus (n = 1). In the WRI group, respiratory viruses were detected in 12 of the 24 patients: influenza AH3 (n = 3), human rhinovirus (n = 3), respiratory syncytial virus (n = 3), human metapneumovirus (n = 3), human bocavirus (n = 2) and human enterovirus (n = 1). Simultaneous detection of two viruses was recorded in two samples in both groups. Conclusions: The results of this study suggest the presence of common respiratory viruses in the lower respiratory tract without causing symptomatic infection, even in carefully collected lower samples. This may have important implications on the interpretation of the results on the diagnostic setting. © 2020 The Author(s).",Human microbiome; Real-time PCR; Respiratory virome; Respiratory viruses,acute respiratory failure; Adenoviridae; adult; aged; APACHE; Article; artificial ventilation; clinical article; controlled study; Coronaviridae; Enterovirus; female; human; Human bocavirus; human coronavirus group 1; human coronavirus group 2; Human metapneumovirus; Human parainfluenza virus 1; Human parainfluenza virus 2; Human parainfluenza virus 3; Human parainfluenza virus 4; Human respiratory syncytial virus; Human rhinovirus; Influenza A virus; Influenza B virus; lung lavage; male; nonhuman; observational study; prospective study; real time polymerase chain reaction; respiratory virus,"Marchesi, J.R., Ravel, J., The vocabulary of microbiome research: A proposal (2015) Microbiome, 30 (3), p. 31; Clarridge, J.E., III, Impact of 16S rRNA gene sequence analysis for identification of bacteria on clinical microbiology and infectious diseases (2004) Clin Microbiol Rev, 17 (4), pp. 840-862. , 1:CAS:528:DC%2BD2cXhtVSht7nM; Zou, S., Caler, L., Colombini-Hatch, S., Glynn, S., Srinivas, P., Research on the human virome: Where are we and what is next (2016) Microbiome, 4, p. 32; Faner, R., Sibila, O., Agustí, A., Bernasconi, E., Chalmers, J.D., Huffnagle, G.B., Manichanh, C., Monsó, E., The microbiome in respiratory medicine: Current Challenges and future perspectives (2017) Eur Respir J, 49 (4); Thorpe, J.E., Baughman, R.P., Frame, P.T., Wesseler, T.A., Staneck, J.L., Bronchoalveolar lavage for diagnosing acute bacterial pneumonia (1987) J Infect Dis, 155, pp. 855-861. , 1:STN:280:DyaL2s7mslOqtA%3D%3D; Charlson, E.S., Bittinger, K., Haas, A.R., Fitzgerald, A.S., Frank, I., Yadav, A., Bushman, F.D., Collman, R.G., Topographical continuity of bacterial populations in the healthy human respiratory tract (2011) Am J Resp Crit Care Med, 184, pp. 957-963; Dickson, R.P., Huffnagle, G.B., The Lung Microbiome: New Principles for Respiratory Bacteriology in Health and Disease (2015) PLOS Pathogens, 11 (7), p. e1004923; O'Dwyer, D.N., Dickson, R.P., Moore, B.B., The lung microbiome, immunity and the pathogenesis of chronic lung disease (2016) J Immunol, 196 (12), pp. 4839-4847; Willner, D., Furlan, M., Haynes, M., Schmieder, R., Angly, F.E., Silva, J., Tammadoni, S., Rower, F., Metagenomic analysis of respiratory tract DNA viral communities in cystic fibrosis and non-cystic fibrosis individuals (2009) PLoS One, 4, p. e7370; Willner, D., Haynes, M.R., Furlan, M., Hanson, N., Kirby, B., Lim, Y.W., Rainey, P.B., Rohwer, F., Case studies of the spatial heterogeneity of DNA viruses in the cystic fibrosis lung (2012) Am J Respir Cell Mol Biol, 46, pp. 127-131. , 1:CAS:528:DC%2BC38Xis1Ohs7c%3D; Lysholm, F., Wetterbom, A., Lindau, C., Darban, H., Bjerkner, A., Fahlander, K., Lindberg, A.M., Andersson, B., Characterization of the viral microbiome in patients with severe lower respiratory tract infections, using metagenomic sequencing (2012) PLoS One, 7, p. e30875. , 1:CAS:528:DC%2BC38XjtVeks7o%3D; Wylie, K.M., Mihindukulasuriya, K.A., Sodergren, E., Weinstock, G.M., Storch, G.A., Sequence analysis of the human virome in febrile and afebrile children (2012) PLoS One, 7 (6), p. e27735. , 1:CAS:528:DC%2BC38XptVOjs7c%3D; Wang, Y., Zhu, N., Li, Y., Lu, R., Wang, H., Liu, G., Zou, X., Tan, W., Metagenomic analysis of viral genetic diversity in respiratory samples from children with severe acute respiratory infection in China (2016) Clin Microbiol Infect, 22, p. 458. , 1:CAS:528:DC%2BC28Xhs1Oju7%2FI e1-e9; Xu, L., Zhu, Y., Ren, L., Xu, B., Liu, C., Xie, Z., Shen, K., Characterization of the nasopharyngeal viral microbiome from children with community-acquired pneumonia but negative for Luminex xTAG respiratory viral panel assay detection (2017) J Med Virol, 89 (12), pp. 2098-2107. , 1:CAS:528:DC%2BC2sXhs1ylsL7F; Ruuskanen, O., Lahti, E., Jennings, L.C., Murdoch, D.R., Viral Pneumonia (2011) Lancet, 377, pp. 1264-1275; Chasqueira, M.J., Paixão, P., Rodrigues, M.L., Piedade, C., Caires, I., Palmeiro, T., Botelho, M.A., Neuparth, N., Respiratory infections in elderly people: Viral role in a residente population of elderly care centres in Lisbon, winter 2013-2014 (2018) Int J Infect Dis, 69, pp. 1-7; Luyt, C., Kayser, L., Virus detection in patientes with severe pneumonia: Still more questions than answers? (2012) Am J Respir Crit Care Med, 186 (4), pp. 301-302; Choi, H.S., Hong, S.B., Ko, G.B., Lee, Y., Park, H.J., Park, S.Y., Moon, S.M., Koh, Y., Viral infection in patients with severe pneumonia requiring intensive care unit admission (2012) Am J Respir Crit Care Med, 186 (4), pp. 325-332; Romero-Espinoza, J.A., Moreno-Valencia, Y., Coronel-Tellez, R.H., Castillejos-Lopez, M., Hernandez, A., Dominguez, A., Miliar-Garcia, A., Vasquez-Perez, J., Virome and bacteriome characterization of children with pneumonia and asthma in Mexico City during winter seasons 2014 and 2015 (2015) PLoS One, 13 (2), p. e0192878; Luyt, C., Combes, A., Trouillet, J.L., Nieszkowska, A., Chastre, J., Viral infections in the ICU (2008) Curr Opin Crit Care, 14 (5), pp. 605-608; Luyt, C., Combes, A., Trouillet, J.L., Nieszkowska, A., Chastre, J., Virus-induced acute respiratory distress syndrome: Epidemiology, management and outcome (2011) Presse Med, 40 (12), pp. e561-e568; Forel, J.M., Martin-Loeches, I., Luyt, C.E., Treating HSV and CMV reactivations in critically ill patients who are not immunocompromised: Pro (2014) Intensive Care Med, 40 (12), pp. 1945-1949","Nazareth, R.; Hospital Beatriz Ângelo, Avenida Carlos Teixeira 3, Portugal; email: raquelnazareth@gmail.com",,BioMed Central Ltd.,14712466,,BPMMB,32054471,English,BMC Pulm. Med.,Article,Final,Open Access,Scopus,2-s2.0-85079339566,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Bajema K.L., Oster A.M., McGovern O.L., Lindstrom S., Stenger M.R., Anderson T.C., Isenhour C., Clarke K.R., Evans M.E., Chu V.T., Biggs H.M., Kirking H.L., Gerber S.I., Hall A.J., Fry A.M., Oliver S.E., 2019-nCoV Persons Under Investigation Team, 2019-CoV Persons Under Investigation Team",56426236200;26030546000;57210569646;35582139100;57215140049;57215141503;57215134010;57216144735;57215118708;57215129403;46460986500;34874964500;57215512132;57215807024;13407240200;57214017583;,"Persons Evaluated for 2019 Novel Coronavirus - United States, January 2020",2020,MMWR. Morbidity and mortality weekly report,69,6,,166,170,,1,10.15585/mmwr.mm6906e1,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079334297&doi=10.15585%2fmmwr.mm6906e1&partnerID=40&md5=7ae8f7dab8beea88a6948a1d1fe3aa14,,"Bajema, K.L.; Oster, A.M.; McGovern, O.L.; Lindstrom, S.; Stenger, M.R.; Anderson, T.C.; Isenhour, C.; Clarke, K.R.; Evans, M.E.; Chu, V.T.; Biggs, H.M.; Kirking, H.L.; Gerber, S.I.; Hall, A.J.; Fry, A.M.; Oliver, S.E.; 2019-nCoV Persons Under Investigation Team; 2019-CoV Persons Under Investigation Team","In December 2019, a cluster of cases of pneumonia emerged in Wuhan City in central China's Hubei Province. Genetic sequencing of isolates obtained from patients with pneumonia identified a novel coronavirus (2019-nCoV) as the etiology (1). As of February 4, 2020, approximately 20,000 confirmed cases had been identified in China and an additional 159 confirmed cases in 23 other countries, including 11 in the United States (2,3). On January 17, CDC and the U.S. Department of Homeland Security's Customs and Border Protection began health screenings at U.S. airports to identify ill travelers returning from Wuhan City (4). CDC activated its Emergency Operations Center on January 21 and formalized a process for inquiries regarding persons suspected of having 2019-nCoV infection (2). As of January 31, 2020, CDC had responded to clinical inquiries from public health officials and health care providers to assist in evaluating approximately 650 persons thought to be at risk for 2019-nCoV infection. Guided by CDC criteria for the evaluation of persons under investigation (PUIs) (5), 210 symptomatic persons were tested for 2019-nCoV; among these persons, 148 (70%) had travel-related risk only, 42 (20%) had close contact with an ill laboratory-confirmed 2019-nCoV patient or PUI, and 18 (9%) had both travel- and contact-related risks. Eleven of these persons had laboratory-confirmed 2019-nCoV infection. Recognizing persons at risk for 2019-nCoV is critical to identifying cases and preventing further transmission. Health care providers should remain vigilant and adhere to recommended infection prevention and control practices when evaluating patients for possible 2019-nCoV infection (6). Providers should consult with their local and state health departments when assessing not only ill travelers from 2019-nCoV-affected countries but also ill persons who have been in close contact with patients with laboratory-confirmed 2019-nCoV infection in the United States.",,"severe acute respiratory syndrome coronavirus 2; adolescent; adult; aged; Betacoronavirus; child; contact examination; Coronavirus infection; epidemic; female; human; isolation and purification; male; mass screening; middle aged; preschool child; risk assessment; travel related disease; United States; young adult; Adolescent; Adult; Aged; Betacoronavirus; Centers for Disease Control and Prevention, U.S.; Child; Child, Preschool; Contact Tracing; Coronavirus Infections; Disease Outbreaks; Female; Humans; Male; Mass Screening; Middle Aged; Risk Assessment; Travel-Related Illness; United States; Young Adult",,,,NLM (Medline),1545861X,,,32053579,English,MMWR Morb. Mortal. Wkly. Rep.,Article,Final,Open Access,Scopus,2-s2.0-85079334297,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Mahase E.,57208387961;,Coronavirus: home testing pilot launched in London to cut hospital visits and ambulance use,2020,BMJ (Clinical research ed.),368,,,m621,,,1,10.1136/bmj.m621,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079360756&doi=10.1136%2fbmj.m621&partnerID=40&md5=bca910db3dc8968690453acf6144ea02,BMJ,"Mahase, E., BMJ",[No abstract available],,,,,,NLM (Medline),17561833,,,32060015,English,BMJ,Article,Final,Open Access,Scopus,2-s2.0-85079360756,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Cohen J., Kupferschmidt K.",57203682506;37095697200;,Labs scramble to produce new coronavirus diagnostics,2020,"Science (New York, N.Y.)",367,6479,,727,,,,10.1126/science.367.6479.727,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079339329&doi=10.1126%2fscience.367.6479.727&partnerID=40&md5=512e29a2bdae4addd5ded77b479a9e17,,"Cohen, J.; Kupferschmidt, K.",[No abstract available],,,,,,NLM (Medline),10959203,,,32054740,English,Science,Article,Final,,Scopus,2-s2.0-85079339329,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Xie C., Lau E.H.Y., Yoshida T., Yu H., Wang X., Wu H., Wei J., Cowling B., Peiris M., Li Y., Yen H.-L.",57215122489;7103086074;57215122186;57144967500;57208309874;57215122299;55842068700;8644765500;7005486823;57204521929;7102476668;,Detection of Influenza and Other Respiratory Viruses in Air Sampled From a University Campus: A Longitudinal Study,2020,Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,70,5,,850,858,,,10.1093/cid/ciz296,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079345429&doi=10.1093%2fcid%2fciz296&partnerID=40&md5=3e919b8202f3d8a2d122f4df9d438d39,"School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China; Department of Mechanical Engineering, University of Hong Kong, Hong Kong Special Administrative Region, China","Xie, C., School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China; Lau, E.H.Y., School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China; Yoshida, T., School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China; Yu, H., Department of Mechanical Engineering, University of Hong Kong, Hong Kong Special Administrative Region, China; Wang, X., School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China; Wu, H., School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China; Wei, J., Department of Mechanical Engineering, University of Hong Kong, Hong Kong Special Administrative Region, China; Cowling, B., School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China; Peiris, M., School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China; Li, Y., Department of Mechanical Engineering, University of Hong Kong, Hong Kong Special Administrative Region, China; Yen, H.-L., School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China","BACKGROUND: Respiratory virus-laden particles are commonly detected in the exhaled breath of symptomatic patients or in air sampled from healthcare settings. However, the temporal relationship of detecting virus-laden particles at nonhealthcare locations vs surveillance data obtained by conventional means has not been fully assessed. METHODS: From October 2016 to June 2018, air was sampled weekly from a university campus in Hong Kong. Viral genomes were detected and quantified by real-time reverse-transcription polymerase chain reaction. Logistic regression models were fitted to examine the adjusted odds ratios (aORs) of ecological and environmental factors associated with the detection of virus-laden airborne particles. RESULTS: Influenza A (16.9% [117/694]) and influenza B (4.5% [31/694]) viruses were detected at higher frequencies in air than rhinovirus (2.2% [6/270]), respiratory syncytial virus (0.4% [1/270]), or human coronaviruses (0% [0/270]). Multivariate analyses showed that increased crowdedness (aOR, 2.3 [95% confidence interval {CI}, 1.5-3.8]; P < .001) and higher indoor temperature (aOR, 1.2 [95% CI, 1.1-1.3]; P < .001) were associated with detection of influenza airborne particles, but absolute humidity was not (aOR, 0.9 [95% CI, .7-1.1]; P = .213). Higher copies of influenza viral genome were detected from airborne particles >4 μm in spring and <1 μm in autumn. Influenza A(H3N2) and influenza B viruses that caused epidemics during the study period were detected in air prior to observing increased influenza activities in the community. CONCLUSIONS: Air sampling as a surveillance tool for monitoring influenza activity at public locations may provide early detection signals on influenza viruses that circulate in the community. © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.",airborne particles; human density; influenza and respiratory viruses; surveillance; temporal pattern,,,,,NLM (Medline),15376591,,,30963180,English,Clin. Infect. Dis.,Article,Final,,Scopus,2-s2.0-85079345429,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Chan J.F.-W., Yuan S., Kok K.-H., To K.K.-W., Chu H., Yang J., Xing F., Liu J., Yip C.C.-Y., Poon R.W.-S., Tsoi H.-W., Lo S.K.-F., Chan K.-H., Poon V.K.-M., Chan W.-M., Ip J.D., Cai J.-P., Cheng V.C.-C., Chen H., Hui C.K.-M., Yuen K.-Y.",24278817900;55364121100;7006862631;14323807300;35781456400;57212325485;56906634000;57210023206;14016999800;57215507162;6603822102;57206887379;57207851346;54934161900;55183680600;57211107936;35557916700;23670479400;57215065142;37002906400;36078079100;,A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster,2020,The Lancet,395,10223,,514,523,,153,10.1016/S0140-6736(20)30154-9,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078241697&doi=10.1016%2fS0140-6736%2820%2930154-9&partnerID=40&md5=d04ed2e8ed7ef8ed5722435d468dc09c,"State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, Pokfulam, China; Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Guangdong Province, Shenzhen, China; Department of Medicine, The University of Hong Kong-Shenzhen Hospital, Guangdong Province, Shenzhen, China","Chan, J.F.-W., State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, Pokfulam, China, Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Guangdong Province, Shenzhen, China; Yuan, S., State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, Pokfulam, China; Kok, K.-H., State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, Pokfulam, China; To, K.K.-W., State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, Pokfulam, China, Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Guangdong Province, Shenzhen, China; Chu, H., State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, Pokfulam, China; Yang, J., Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Guangdong Province, Shenzhen, China; Xing, F., Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Guangdong Province, Shenzhen, China; Liu, J., Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Guangdong Province, Shenzhen, China; Yip, C.C.-Y., State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, Pokfulam, China; Poon, R.W.-S., State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, Pokfulam, China; Tsoi, H.-W., State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, Pokfulam, China; Lo, S.K.-F., Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Guangdong Province, Shenzhen, China; Chan, K.-H., State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, Pokfulam, China; Poon, V.K.-M., State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, Pokfulam, China; Chan, W.-M., State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, Pokfulam, China; Ip, J.D., State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, Pokfulam, China; Cai, J.-P., State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, Pokfulam, China; Cheng, V.C.-C., State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, Pokfulam, China; Chen, H., State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, Pokfulam, China, Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Guangdong Province, Shenzhen, China; Hui, C.K.-M., Department of Medicine, The University of Hong Kong-Shenzhen Hospital, Guangdong Province, Shenzhen, China; Yuen, K.-Y., Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Guangdong Province, Shenzhen, China","Background: An ongoing outbreak of pneumonia associated with a novel coronavirus was reported in Wuhan city, Hubei province, China. Affected patients were geographically linked with a local wet market as a potential source. No data on person-to-person or nosocomial transmission have been published to date. Methods: In this study, we report the epidemiological, clinical, laboratory, radiological, and microbiological findings of five patients in a family cluster who presented with unexplained pneumonia after returning to Shenzhen, Guangdong province, China, after a visit to Wuhan, and an additional family member who did not travel to Wuhan. Phylogenetic analysis of genetic sequences from these patients were done. Findings: From Jan 10, 2020, we enrolled a family of six patients who travelled to Wuhan from Shenzhen between Dec 29, 2019 and Jan 4, 2020. Of six family members who travelled to Wuhan, five were identified as infected with the novel coronavirus. Additionally, one family member, who did not travel to Wuhan, became infected with the virus after several days of contact with four of the family members. None of the family members had contacts with Wuhan markets or animals, although two had visited a Wuhan hospital. Five family members (aged 36–66 years) presented with fever, upper or lower respiratory tract symptoms, or diarrhoea, or a combination of these 3–6 days after exposure. They presented to our hospital (The University of Hong Kong-Shenzhen Hospital, Shenzhen) 6–10 days after symptom onset. They and one asymptomatic child (aged 10 years) had radiological ground-glass lung opacities. Older patients (aged >60 years) had more systemic symptoms, extensive radiological ground-glass lung changes, lymphopenia, thrombocytopenia, and increased C-reactive protein and lactate dehydrogenase levels. The nasopharyngeal or throat swabs of these six patients were negative for known respiratory microbes by point-of-care multiplex RT-PCR, but five patients (four adults and the child) were RT-PCR positive for genes encoding the internal RNA-dependent RNA polymerase and surface Spike protein of this novel coronavirus, which were confirmed by Sanger sequencing. Phylogenetic analysis of these five patients' RT-PCR amplicons and two full genomes by next-generation sequencing showed that this is a novel coronavirus, which is closest to the bat severe acute respiatory syndrome (SARS)-related coronaviruses found in Chinese horseshoe bats. Interpretation: Our findings are consistent with person-to-person transmission of this novel coronavirus in hospital and family settings, and the reports of infected travellers in other geographical regions. Funding: The Shaw Foundation Hong Kong, Michael Seak-Kan Tong, Respiratory Viral Research Foundation Limited, Hui Ming, Hui Hoy and Chow Sin Lan Charity Fund Limited, Marina Man-Wai Lee, the Hong Kong Hainan Commercial Association South China Microbiology Research Fund, Sanming Project of Medicine (Shenzhen), and High Level-Hospital Program (Guangdong Health Commission). © 2020 Elsevier Ltd",,"C reactive protein; RNA directed DNA polymerase; virus spike protein; COVID-19; severe acute respiratory syndrome coronavirus 2; 2019 novel coronavirus; adult; aged; amplicon; Article; child; China; clinical article; clinical examination; controlled study; Coronavirinae; Coronavirus infection; diarrhea; disease association; disease transmission; exposure variable; family; female; fever; gene sequence; genetic code; genomics; high throughput sequencing; history; human; laboratory test; lower respiratory tract infection; lymphocytopenia; male; microbiological examination; nonhuman; phylogeny; pneumonia; priority journal; radiodiagnosis; real time polymerase chain reaction; Sanger sequencing; school child; throat culture; thrombocytopenia; travel; upper respiratory tract infection; virus transmission; Betacoronavirus; classification; Coronavirus infection; family health; genetics; middle aged; procedures; thorax radiography; virus genome; virus pneumonia; whole genome sequencing; x-ray computed tomography; Adult; Aged; Betacoronavirus; China; Coronavirus Infections; Family Health; Genome, Viral; Humans; Middle Aged; Phylogeny; Pneumonia, Viral; Radiography, Thoracic; Tomography, X-Ray Computed; Whole Genome Sequencing","CHP closely monitors cluster of pneumonia cases on Mainland (2019), https://www.info.gov.hk/gia/general/201912/31/P2019123100667.htm, (Accessed 21 January 2020); CHP provides further information on cluster of pneumonia cases in Wuhan (2020), https://www.info.gov.hk/gia/general/202001/12/P2020011200710.htm, (Accessed 21 January 2020); Juan, D., Wuhan wet market closes amid pneumonia outbreak (2020) ChinaDaily, , https://www.chinadaily.com.cn/a/202001/01/WS5e0c6a49a310cf3e35581e30.html, (Accessed 21 January 2020); 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Peiris, J.S., Lai, S.T., Poon, L.L., Coronavirus as a possible cause of severe acute respiratory syndrome (2003) Lancet, 361, pp. 1319-1325; Chan, J.F., Zhang, A.J., Chan, C.C., Zika virus infection in dexamethasone-immunosuppressed mice demonstrating disseminated infection with multi-organ involvement including orchitis effectively treated by recombinant type I interferons (2016) EBioMedicine, 14, pp. 112-122; To, K.K.W., Chan, W.M., Li, K.S.M., High prevalence of four novel astrovirus genotype species identified from rodents in China (2017) J Gen Virol, 98, pp. 1004-1015; Woo, P.C., Lau, S.K., Teng, J.L., Metagenomic analysis of viromes of dromedary camel fecal samples reveals large number and high diversity of circoviruses and picobirnaviruses (2014) Virology, 471-73, pp. 117-125; Tse, H., Tsang, A.K., Tsoi, H.W., Identification of a novel bat papillomavirus by metagenomics (2012) PLoS One, 7; Lewandowski, K., Xu, Y., Pullan, S.T., Metagenomic nanopore sequencing of influenza virus direct from clinical respiratory samples (2019) J Clin Microbiol, 58, pp. e00963-e01019; Lau, S.K., Feng, Y., Chen, H., Severe acute respiratory syndrome (SARS) coronavirus ORF8 protein is acquired from SARS-related coronavirus from greater horseshoe bats through recombination (2015) J Virol, 89, pp. 10532-10547; Peiris, J.S., Chu, C.M., Cheng, V.C., Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study (2003) Lancet, 361, pp. 1767-1772; Cheng, V.C., Lau, S.K., Woo, P.C., Yuen, K.Y., Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection (2007) Clin Microbiol Rev, 20, pp. 660-694; Che, X.Y., Di, B., Zhao, G.P., A patient with asymptomatic severe acute respiratory syndrome (SARS) and antigenemia from the 2003–2004 community outbreak of SARS in Guangzhou, China (2006) Clin Infect Dis, 43, pp. e1-e5; Cheng, V.C., Hung, I.F., Tang, B.S., Viral replication in the nasopharynx is associated with diarrhea in patients with severe acute respiratory syndrome (2004) Clin Infect Dis, 38, pp. 467-475; 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Woo, P.C., Lau, S.K., Lam, C.S., Discovery of seven novel mammalian and avian coronaviruses in the genus deltacoronavirus supports bat coronaviruses as the gene source of alphacoronavirus and betacoronavirus and avian coronaviruses as the gene source of gammacoronavirus and deltacoronavirus (2012) J Virol, 86, pp. 3995-4008; Lau, S.K., Woo, P.C., Li, K.S., Discovery of a novel coronavirus, China Rattus coronavirus HKU24, from Norway rats supports the murine origin of Betacoronavirus 1 and has implications for the ancestor of Betacoronavirus lineage A (2015) J Virol, 89, pp. 3076-3092; Hu, D., Zhu, C., Ai, L., Genomic characterization and infectivity of a novel SARS-like coronavirus in Chinese bats (2018) Emerg Microbes Infect, 7, p. 154; Lau, S.K., Woo, P.C., Li, K.S., Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats (2005) Proc Natl Acad Sci USA, 102, pp. 14040-14045; Li, W., Shi, Z., Yu, M., Bats are natural reservoirs of SARS-like coronaviruses (2005) Science, 310, pp. 676-679; Che, X.Y., Qiu, L.W., Liao, Z.Y., Antigenic cross-reactivity between severe acute respiratory syndrome-associated coronavirus and human coronaviruses 229E and OC43 (2005) J Infect Dis, 191, pp. 2033-2037","Yuen, K.-Y.; Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Guangdong Province, China; email: kyyuen@hku.hk",,Lancet Publishing Group,1406736,,LANCA,31986261,English,Lancet,Article,Final,Open Access,Scopus,2-s2.0-85078241697,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, [No author name available],[No author id available],"Department of Error: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (The Lancet (2020) 395(10223) (497–506), (S0140673620301835), (10.1016/S0140-6736(20)30183-5))",2020,The Lancet,395,10223,,496,,,,10.1016/S0140-6736(20)30252-X,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079124425&doi=10.1016%2fS0140-6736%2820%2930252-X&partnerID=40&md5=0fd2ccb70e8e036de6ea0b3fb9811986,,,"Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020; published online Jan 24. https://doi.org/10.1016/S0140-6736(20)30183-5—In this Article, in Procedures, we have corrected the primer sequences for targeting the envelope gene of coronavirus; in the Summary and Data collection, we have corrected the text to reflect that the modified case record form for severe acute respiratory infection clinical characterisation was developed by WHO and the International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) together; we have updated the margin link to the ISARIC–WHO case record form; we have updated the Acknowledgments; and in the tables, we updated p values (three in table 2 and one each in tables 1 and 3) so that they are all given to two significant figures. These corrections have been made to the online version as of Jan 30, 2020, and will be made to the printed version. © 2020 Elsevier Ltd",,erratum,,,,Lancet Publishing Group,1406736,,LANCA,32007144,English,Lancet,Erratum,Final,Open Access,Scopus,2-s2.0-85079124425,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, [No author name available],[No author id available],"Department of Error: A novel coronavirus outbreak of global health concern (The Lancet (2020) 395(10223) (470–473), (S0140673620301859), (10.1016/S0140-6736(20)30185-9))",2020,The Lancet,395,10223,,496,,,,10.1016/S0140-6736(20)30250-6,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079195968&doi=10.1016%2fS0140-6736%2820%2930250-6&partnerID=40&md5=da6dbdd97ec6822301a0a20f9e5d90b4,,,"Wang C, Horby PW, Hayden FG, Gao GF. A novel coronavirus outbreak of global health concern. Lancet 2020; published online Jan 24. https://dox.doi.org/S0140-6736(20)30185-9—In this Comment, the first sentence of the third paragraph should have read “Of the 41 patients in this cohort, 22 (55%) developed severe dyspnoea and 13 (32%) required admission to an intensive care unit, and six died.” And in the table, the title of the third row should have read “Location of first detection”. These corrections have been made to the online version as of Jan 29, 2020, and will be made to the printed version. © 2020 Elsevier Ltd",,erratum,,,,Lancet Publishing Group,1406736,,LANCA,32006465,English,Lancet,Erratum,Final,Open Access,Scopus,2-s2.0-85079195968,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Huang C., Wang Y., Li X., Ren L., Zhao J., Hu Y., Zhang L., Fan G., Xu J., Gu X., Cheng Z., Yu T., Xia J., Wei Y., Wu W., Xie X., Yin W., Li H., Liu M., Xiao Y., Gao H., Guo L., Xie J., Wang G., Jiang R., Gao Z., Jin Q., Wang J., Cao B.",57214757309;57200608527;7501697688;7202371986;7410313832;57214754517;57215061891;57201116770;57215364706;57214399398;57214753403;57214909863;57214460628;57214467086;57214756457;57214753146;57214756133;57214759415;56323443300;57198733311;7402971042;57196862773;7402994596;7407150793;57215348967;57214749380;57214753343;56147682700;26022302100;,"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China",2020,The Lancet,395,10223,,497,506,,315,10.1016/S0140-6736(20)30183-5,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078262578&doi=10.1016%2fS0140-6736%2820%2930183-5&partnerID=40&md5=ec31b8386712376b44af67cd05d36394,"Jin Yin-tan Hospital, Wuhan, China; Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing, China; Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China; Department of Radiology, China-Japan Friendship Hospital, Beijing, China; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China; Department of Respiratory Medicine, Capital Medical University, Beijing, China; Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China; NHC Key Laboratory of Systems Biology of Pathogens and Christophe Merieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Pulmonary and Critical Care Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Tsinghua University School of Medicine, Beijing, China; Department of Respiratory medicine, Zhongnan Hospital of Wuhan University, Wuhan, China; Department of Pulmonary and Critical Care Medicine, Peking University First Hospital, Beijing, China; Department of Pulmonary and Critical Care Medicine, Peking University People's Hospital, Beijing, China; Tsinghua University-Peking University Joint Center for Life Sciences, Beijing, China","Huang, C., Jin Yin-tan Hospital, Wuhan, China; Wang, Y., Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing, China, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China, Department of Respiratory Medicine, Capital Medical University, Beijing, China; Li, X., Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China; Ren, L., NHC Key Laboratory of Systems Biology of Pathogens and Christophe Merieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Zhao, J., Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Hu, Y., Department of Pulmonary and Critical Care Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Zhang, L., Jin Yin-tan Hospital, Wuhan, China; Fan, G., Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing, China, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China; Xu, J., Tsinghua University School of Medicine, Beijing, China; Gu, X., Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing, China, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China; Cheng, Z., Department of Respiratory medicine, Zhongnan Hospital of Wuhan University, Wuhan, China; Yu, T., Jin Yin-tan Hospital, Wuhan, China; Xia, J., Jin Yin-tan Hospital, Wuhan, China; Wei, Y., Jin Yin-tan Hospital, Wuhan, China; Wu, W., Jin Yin-tan Hospital, Wuhan, China; Xie, X., Jin Yin-tan Hospital, Wuhan, China; Yin, W., Department of Pulmonary and Critical Care Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Li, H., Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing, China, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China, Department of Respiratory Medicine, Capital Medical University, Beijing, China; Liu, M., Department of Radiology, China-Japan Friendship Hospital, Beijing, China; Xiao, Y., NHC Key Laboratory of Systems Biology of Pathogens and Christophe Merieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Gao, H., Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Guo, L., NHC Key Laboratory of Systems Biology of Pathogens and Christophe Merieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Xie, J., Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Wang, G., Department of Pulmonary and Critical Care Medicine, Peking University First Hospital, Beijing, China; Jiang, R., Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China; Gao, Z., Department of Pulmonary and Critical Care Medicine, Peking University People's Hospital, Beijing, China; Jin, Q., NHC Key Laboratory of Systems Biology of Pathogens and Christophe Merieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Wang, J., NHC Key Laboratory of Systems Biology of Pathogens and Christophe Merieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Cao, B., Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing, China, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China, Department of Respiratory Medicine, Capital Medical University, Beijing, China, Tsinghua University-Peking University Joint Center for Life Sciences, Beijing, China","Background: A recent cluster of pneumonia cases in Wuhan, China, was caused by a novel betacoronavirus, the 2019 novel coronavirus (2019-nCoV). We report the epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of these patients. Methods: All patients with suspected 2019-nCoV were admitted to a designated hospital in Wuhan. We prospectively collected and analysed data on patients with laboratory-confirmed 2019-nCoV infection by real-time RT-PCR and next-generation sequencing. Data were obtained with standardised data collection forms shared by WHO and the International Severe Acute Respiratory and Emerging Infection Consortium from electronic medical records. Researchers also directly communicated with patients or their families to ascertain epidemiological and symptom data. Outcomes were also compared between patients who had been admitted to the intensive care unit (ICU) and those who had not. Findings: By Jan 2, 2020, 41 admitted hospital patients had been identified as having laboratory-confirmed 2019-nCoV infection. Most of the infected patients were men (30 [73%] of 41); less than half had underlying diseases (13 [32%]), including diabetes (eight [20%]), hypertension (six [15%]), and cardiovascular disease (six [15%]). Median age was 49·0 years (IQR 41·0–58·0). 27 (66%) of 41 patients had been exposed to Huanan seafood market. One family cluster was found. Common symptoms at onset of illness were fever (40 [98%] of 41 patients), cough (31 [76%]), and myalgia or fatigue (18 [44%]); less common symptoms were sputum production (11 [28%] of 39), headache (three [8%] of 38), haemoptysis (two [5%] of 39), and diarrhoea (one [3%] of 38). Dyspnoea developed in 22 (55%) of 40 patients (median time from illness onset to dyspnoea 8·0 days [IQR 5·0–13·0]). 26 (63%) of 41 patients had lymphopenia. All 41 patients had pneumonia with abnormal findings on chest CT. Complications included acute respiratory distress syndrome (12 [29%]), RNAaemia (six [15%]), acute cardiac injury (five [12%]) and secondary infection (four [10%]). 13 (32%) patients were admitted to an ICU and six (15%) died. Compared with non-ICU patients, ICU patients had higher plasma levels of IL2, IL7, IL10, GSCF, IP10, MCP1, MIP1A, and TNFα. Interpretation: The 2019-nCoV infection caused clusters of severe respiratory illness similar to severe acute respiratory syndrome coronavirus and was associated with ICU admission and high mortality. Major gaps in our knowledge of the origin, epidemiology, duration of human transmission, and clinical spectrum of disease need fulfilment by future studies. Funding: Ministry of Science and Technology, Chinese Academy of Medical Sciences, National Natural Science Foundation of China, and Beijing Municipal Science and Technology Commission. © 2020 Elsevier Ltd",,"antibiotic agent; gamma interferon inducible protein 10; granulocyte colony stimulating factor; interleukin 10; interleukin 2; interleukin 7; macrophage inflammatory protein 1alpha; methylprednisolone; monocyte chemotactic protein 1; oseltamivir; oxygen; tumor necrosis factor; COVID-19; 2019 novel coronavirus; adult; adult respiratory distress syndrome; Article; cardiovascular disease; China; clinical article; clinical feature; clinical outcome; cohort analysis; community acquired pneumonia; computer assisted tomography; controlled study; Coronavirinae; coronavirus disease 2019; Coronavirus infection; coughing; diabetes mellitus; diarrhea; disease severity; dyspnea; electronic medical record; environmental exposure; family study; fatigue; female; fever; gamma interferon inducible protein 10 blood level; granulocyte colony stimulating factor blood level; headache; heart injury; hemoptysis; high throughput sequencing; hospital admission; human; human cell; hypertension; hypoxemia; intensive care unit; interleukin 10 blood level; interleukin 2 blood level; interleukin 7 blood level; laboratory test; lymphocytopenia; macrophage inflammatory protein 1alpha blood level; male; monocyte chemotactic protein 1 blood level; mortality rate; myalgia; nonhuman; pneumonia; priority journal; prospective study; protein blood level; radiodiagnosis; real time reverse transcription polymerase chain reaction; RNA virus infection; RNAaemia; sea food; secondary infection; sputum; standardization; symptom; thorax radiography; treatment response; tumor necrosis factor blood level; virus pneumonia; World Health Organization; adult respiratory distress syndrome; age distribution; aged; comorbidity; complication; Coronavirus infection; coughing; fever; hospitalization; middle aged; myalgia; prognosis; time factor; virology; virus pneumonia; x-ray computed tomography; young adult; Adult; Age Distribution; Aged; China; Comorbidity; Coronavirus Infections; Cough; Female; Fever; Hospitalization; Humans; Intensive Care Units; Male; Middle Aged; Myalgia; Pneumonia, Viral; Prognosis; Radiography, Thoracic; Respiratory Distress Syndrome, Adult; Time Factors; Tomography, X-Ray Computed; Young Adult","Richman, D.D., Whitley, R.J., Hayden, F.G., Clinical virology (2016), 4th edn. 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(2014) PLoS One, 9; Falzarano, D., de Wit, E., Rasmussen, A.L., Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques (2013) Nat Med, 19, pp. 1313-1317; Stockman, L.J., Bellamy, R., Garner, P., SARS: systematic review of treatment effects (2006) PLoS Med, 3, p. e343; Lansbury, L., Rodrigo, C., Leonardi-Bee, J., Nguyen-Van-Tam, J., Lim, W.S., Corticosteroids as adjunctive therapy in the treatment of influenza (2019) Cochrane Database Syst Rev, 2, p. CD010406; Arabi, Y.M., Mandourah, Y., Al-Hameed, F., Corticosteroid therapy for critically ill patients with Middle East respiratory syndrome (2018) Am J Respir Crit Care Med, 197, pp. 757-767; Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected (2020), https://www.who.int/internal-publications-detail/clinical-management-of-severe-acute-respiratory-infection-when-novel-coronavirus-(ncov)-infection-is-suspected, (Accessed 19 January 2020); Chu, C.M., Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings (2004) Thorax, 59, pp. 252-256; Arabi, Y.M., Alothman, A., Balkhy, H.H., Treatment of Middle East respiratory syndrome with a combination of lopinavir-ritonavir and interferon-β1b (MIRACLE trial): study protocol for a randomized controlled trial (2018) Trials, 19, p. 81; Sheahan, T.P., Sims, A.C., Graham, R.L., Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses (2017) Sci Transl Med, 9; Sheahan, T.P., Sims, A.C., Leist, S.R., Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV (2020) Nat Commun, 11, p. 222; Cui, J., Li, F., Shi, Z.-L., Origin and evolution of pathogenic coronaviruses (2019) Nat Rev Microbiol, 17, pp. 181-192; Ge, X.-Y., Li, J.-L., Yang, X.-L., Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor (2013) Nature, 503, pp. 535-538; Wang, M., Hu, Z., Bats as animal reservoirs for the SARS coronavirus: hypothesis proved after 10 years of virus hunting (2013) Virol Sin, 28, pp. 315-317","Cao, B.; Department of Pulmonary and Critical Care Medicine, China-Japan Friendship HospitalChina; email: caobin_ben@163.com",,Lancet Publishing Group,1406736,,LANCA,31986264,English,Lancet,Article,Final,Open Access,Scopus,2-s2.0-85078262578,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Chen N., Zhou M., Dong X., Qu J., Gong F., Han Y., Qiu Y., Wang J., Liu Y., Wei Y., Xia J., Yu T., Zhang X., Zhang L.",57214450032;57190412099;57214472785;7201535093;57214459759;57214472997;57212585545;57214464338;57214466689;57214467086;57214460628;57214909863;55715548900;57202313986;,"Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study",2020,The Lancet,395,10223,,507,513,,173,10.1016/S0140-6736(20)30211-7,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078761741&doi=10.1016%2fS0140-6736%2820%2930211-7&partnerID=40&md5=4f69b2ff8156236477a98c94585f393b,"Tuberculosis and Respiratory Department, Wuhan Jinyintan Hospital, Wuhan, China; Infection Disease Department, Wuhan Jinyintan Hospital, Wuhan, China; Science and Education Department, Wuhan Jinyintan Hospital, Wuhan, China; The Office of Drug Clinical Trial Institution, Wuhan Jinyintan Hospital, Wuhan, China; Department of Respiratory and Critical Care Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; Institute of Respiratory Diseases, Shanghai Jiaotong University School of Medicine, Shanghai, China; Research Laboratory of Clinical Virology, Ruijin Hospital and Ruijin Hospital North, Shanghai Jiaotong University School of Medicine, Shanghai, China; Clinical Research Center, Ruijin Hospital North, Shanghai Jiaotong University School of Medicine, Shanghai, China; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China","Chen, N., Tuberculosis and Respiratory Department, Wuhan Jinyintan Hospital, Wuhan, China; Zhou, M., Department of Respiratory and Critical Care Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, Institute of Respiratory Diseases, Shanghai Jiaotong University School of Medicine, Shanghai, China; Dong, X., Tuberculosis and Respiratory Department, Wuhan Jinyintan Hospital, Wuhan, China; Qu, J., Department of Respiratory and Critical Care Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China, Institute of Respiratory Diseases, Shanghai Jiaotong University School of Medicine, Shanghai, China; Gong, F., Infection Disease Department, Wuhan Jinyintan Hospital, Wuhan, China; Han, Y., Science and Education Department, Wuhan Jinyintan Hospital, Wuhan, China, State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Qiu, Y., State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Wang, J., Infection Disease Department, Wuhan Jinyintan Hospital, Wuhan, China; Liu, Y., The Office of Drug Clinical Trial Institution, Wuhan Jinyintan Hospital, Wuhan, China; Wei, Y., Tuberculosis and Respiratory Department, Wuhan Jinyintan Hospital, Wuhan, China; Xia, J., Tuberculosis and Respiratory Department, Wuhan Jinyintan Hospital, Wuhan, China; Yu, T., Tuberculosis and Respiratory Department, Wuhan Jinyintan Hospital, Wuhan, China; Zhang, X., Research Laboratory of Clinical Virology, Ruijin Hospital and Ruijin Hospital North, Shanghai Jiaotong University School of Medicine, Shanghai, China, Clinical Research Center, Ruijin Hospital North, Shanghai Jiaotong University School of Medicine, Shanghai, China; Zhang, L., Tuberculosis and Respiratory Department, Wuhan Jinyintan Hospital, Wuhan, China","Background: In December, 2019, a pneumonia associated with the 2019 novel coronavirus (2019-nCoV) emerged in Wuhan, China. We aimed to further clarify the epidemiological and clinical characteristics of 2019-nCoV pneumonia. Methods: In this retrospective, single-centre study, we included all confirmed cases of 2019-nCoV in Wuhan Jinyintan Hospital from Jan 1 to Jan 20, 2020. Cases were confirmed by real-time RT-PCR and were analysed for epidemiological, demographic, clinical, and radiological features and laboratory data. Outcomes were followed up until Jan 25, 2020. Findings: Of the 99 patients with 2019-nCoV pneumonia, 49 (49%) had a history of exposure to the Huanan seafood market. The average age of the patients was 55·5 years (SD 13·1), including 67 men and 32 women. 2019-nCoV was detected in all patients by real-time RT-PCR. 50 (51%) patients had chronic diseases. Patients had clinical manifestations of fever (82 [83%] patients), cough (81 [82%] patients), shortness of breath (31 [31%] patients), muscle ache (11 [11%] patients), confusion (nine [9%] patients), headache (eight [8%] patients), sore throat (five [5%] patients), rhinorrhoea (four [4%] patients), chest pain (two [2%] patients), diarrhoea (two [2%] patients), and nausea and vomiting (one [1%] patient). According to imaging examination, 74 (75%) patients showed bilateral pneumonia, 14 (14%) patients showed multiple mottling and ground-glass opacity, and one (1%) patient had pneumothorax. 17 (17%) patients developed acute respiratory distress syndrome and, among them, 11 (11%) patients worsened in a short period of time and died of multiple organ failure. Interpretation: The 2019-nCoV infection was of clustering onset, is more likely to affect older males with comorbidities, and can result in severe and even fatal respiratory diseases such as acute respiratory distress syndrome. In general, characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia. Further investigation is needed to explore the applicability of the MuLBSTA score in predicting the risk of mortality in 2019-nCoV infection. Funding: National Key R&D Program of China. © 2020 Elsevier Ltd",,"adult; age; Article; China; chronic disease; clinical feature; confusion; Coronavirus disease 2019; Coronavirus infection; coughing; descriptive research; disease exacerbation; dyspnea; epidemiological data; exposure; female; fever; follow up; headache; human; major clinical study; male; marketing; medical history; multiple organ failure; myalgia; nausea and vomiting; pneumothorax; priority journal; real time polymerase chain reaction; respiratory distress; retrospective study; sea food; sore throat; thorax pain; virus detection; virus pneumonia; aged; comorbidity; complication; Coronavirus infection; coughing; dyspnea; epidemic; fever; middle aged; prognosis; severe acute respiratory syndrome; thorax radiography; very elderly; virology; virus pneumonia; x-ray computed tomography; young adult; COVID-19; Adult; Aged; Aged, 80 and over; China; Comorbidity; Coronavirus Infections; Cough; Disease Outbreaks; Dyspnea; Female; Fever; Humans; Male; Middle Aged; Pneumonia, Viral; Prognosis; Radiography, Thoracic; Retrospective Studies; Severe Acute Respiratory Syndrome; Tomography, X-Ray Computed; Young Adult","Lu, H., Stratton, C.W., Tang, Y.W., Outbreak of pneumonia of unknown etiology in Wuhan China: the mystery and the miracle (2020) J Med Virol, , published online Jan 16; Hui, D.S., Azhar, E.I., Madani, T.A., The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health - the latest 2019 novel coronavirus outbreak in Wuhan, China (2020) Int J Infect Dis, 91, pp. 264-266; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, , published online Jan 24; Clinical management of severe acute respiratory infection when Novel coronavirus (nCoV) infection is suspected: interim guidance (2020), https://www.who.int/internal-publications-detail/clinical-management-of-severe-acute-respiratory-infection-when-novel-coronavirus-(ncov)-infection-is-suspected, (Accessed 20 January 2020); Yin, Y., Wunderink, R.G., MERS, SARS and other coronaviruses as causes of pneumonia (2018) Respirology, 23, pp. 130-137; Drosten, C., Günther, S., Preiser, W., Identification of a novel coronavirus in patients with severe acute respiratory syndrome (2003) N Engl J Med, 348, pp. 1967-1976; Zaki, A.M., van Boheemen, S., Bestebroer, T.M., Osterhaus, A.D., Fouchier, R.A., Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia (2012) N Engl J Med, 367, pp. 1814-1820; Guo, L., Wei, D., Zhang, X., Clinical features predicting mortality risk in patients with viral pneumonia: the MuLBSTA score (2019) Front Microbiol, 10; Hu, B., Zeng, L.P., Yang, X.L., Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus (2017) PLoS Pathog, 13; Song, H.D., Tu, C.C., Zhang, G.W., Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human (2005) Proc Natl Acad Sci USA, 102, pp. 2430-2435; Haagmans, B.L., Al Dhahiry, S.H., Reusken, C.B., Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation (2014) Lancet Infect Dis, 14, pp. 140-145; Azhar, E.I., El-Kafrawy, S.A., Farraj, S.A., Evidence for camel-to-human transmission of MERS coronavirus (2014) N Engl J Med, 370, pp. 2499-2505; Tao, Y., Shi, M., Chommanard, C., Surveillance of bat coronaviruses in Kenya identifies relatives of human coronaviruses NL63 and 229E and their recombination history (2017) J Virol, 91, pp. e01953-e02016; Cui, J., Li, F., Shi, Z.L., Origin and evolution of pathogenic coronaviruses (2019) Nat Rev Microbiol, 17, pp. 181-192; Zhou, P., Fan, H., Lan, T., Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin (2018) Nature, 556, pp. 255-258; Xu, X.T., Chen, P., Wang, J.F., Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for the risk of human transmission (2020) Sci China Life Sci, , published online Jan 21; Wuhan coronavirus has strong ability to infect humans. Press release (2020), https://view.inews.qq.com/w2/20200121A0M08X00?tbkt=F&strategy=&openid=o04IBALMrLyGDxbWNOPoDM1IfG-s&uid=&refer=wx_hot, (Accessed 29 January 2020); Song, Z., Xu, Y., Bao, L., From SARS to MERS, thrusting coronaviruses into the spotlight (2019) Viruses, 11, p. 59; Badawi, A., Ryoo, S.G., Prevalence of comorbidities in the Middle East respiratory syndrome coronavirus (MERS-CoV): a systematic review and meta-analysis (2016) Int J Infect Dis, 49, pp. 129-133; Channappanavar, R., Fett, C., Mack, M., Ten Eyck, P.P., Meyerholz, D.K., Perlman, S., Sex-based differences in susceptibility to severe acute respiratory syndrome coronavirus infection (2017) J Immunol, 198, pp. 4046-4053; Jaillon, S., Berthenet, K., Garlanda, C., Sexual dimorphism in innate immunity (2019) Clin Rev Allergy Immunol, 56, pp. 308-321; Dryden, M., Baguneid, M., Eckmann, C., Pathophysiology and burden of infection in patients with diabetes mellitus and peripheral vascular disease: focus on skin and soft-tissue infections (2015) Clin Microbiol Infect, 21, pp. S27-S32; Gao, H.N., Lu, H.Z., Cao, B., Clinical findings in 111 cases of influenza A (H7N9) virus infection (2013) N Engl J Med, 368, pp. 2277-2285; Wang, X.F., Shi, G.C., Wan, H.Y., Clinical features of three avian influenza H7N9 virus-infected patients in Shanghai (2014) Clin Respir J, 8, pp. 410-416; Liu, W.J., Zhao, M., Liu, K., T-cell immunity of SARS-CoV: implications for vaccine development against MERS-CoV (2017) Antiviral Res, 137, pp. 82-92","Zhang, L.; Tuberculosis and Respiratory Department, Wuhan Jinyintan Hospital, Dongxihu District, China; email: zhangli080806@163.com",,Lancet Publishing Group,1406736,,LANCA,32007143,English,Lancet,Article,Final,Open Access,Scopus,2-s2.0-85078761741,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Makoni M.,57191298293;,Africa prepares for coronavirus,2020,"Lancet (London, England)",395,10223,,483,,,2,10.1016/S0140-6736(20)30355-X,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079539502&doi=10.1016%2fS0140-6736%2820%2930355-X&partnerID=40&md5=f908a5829dbb5ca75605aabb8ae2775d,,"Makoni, M.",[No abstract available],,"COVID-19; Africa; Coronavirus infection; epidemic; human; virus pneumonia; World Health Organization; Africa; Coronavirus Infections; Disease Outbreaks; Humans; Pneumonia, Viral; World Health Organization",,,,NLM (Medline),1474547X,,,32061284,English,Lancet,Article,Final,Open Access,Scopus,2-s2.0-85079539502,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Graham Carlos W., Dela Cruz C.S., Cao B., Pasnick S., Jamil S.",57215119479;6602433042;57214870957;56469582400;57202678060;,Novel Wuhan (2019-NCoV) coronavirus,2020,American Journal of Respiratory and Critical Care Medicine,201,4,,P7,P8,,10,10.1164/rccm.2014P7,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079340589&doi=10.1164%2frccm.2014P7&partnerID=40&md5=87c74407d9fedfe1e3dd5c69c1e1a28f,,"Graham Carlos, W.; Dela Cruz, C.S.; Cao, B.; Pasnick, S.; Jamil, S.",[No abstract available],,"2019 novel coronavirus; China; clinical feature; contact isolation; Coronavirus infection; exposure; human; infection prevention; priority journal; Short Survey; United States; virus transmission; Betacoronavirus; complication; Coronavirus infection; coughing; disease transmission; dyspnea; fever; global health; health care delivery; isolation and purification; pathogenicity; patient education; risk factor; travel; virus pneumonia; COVID-19; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; China; Coronavirus Infections; Cough; Delivery of Health Care; Dyspnea; Fever; Global Health; Humans; Infectious Disease Transmission, Patient-to-Professional; Pneumonia, Viral; Risk Factors; Travel","Novel Coronavirus, , https://www.cdc.gov/coronavirus/2019-ncov/about/index.html, 2019 •; Red Book Online, , https://redbook.solutions.aap.org/selfserve/ssPage.aspx?SelfServeContentId=rbo_outbreaks_page_3, •; Zhu, N., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, , • Jan 24; Munster, A novel coronavirus emerging in China - Key questions for impact assessment (2020) N Engl J Med, , • Jan 24; Huang, Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Lancet, p. 2020. , https://doi.org/10.1016/S0140-6736(20)30183-5, • Published Online January 24",,,American Thoracic Society,1073449X,,AJCME,32004066,English,Am. J. Respir. Crit. Care Med.,Short Survey,Final,Open Access,Scopus,2-s2.0-85079340589,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, [No author name available],[No author id available],Coronavirus not to blame for recent supply problems,2020,The Veterinary record,186,6,,172,,,,10.1136/vr.m594,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079337686&doi=10.1136%2fvr.m594&partnerID=40&md5=2ef4abd09e3e8ffcb830e386b1e56ca4,,,[No abstract available],,,,,,NLM (Medline),20427670,,,32054798,English,Vet. Rec.,Article,Final,,Scopus,2-s2.0-85079337686,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wang C., Horby P.W., Hayden F.G., Gao G.F.",54935541900;34975069600;7103233446;7403171212;,A novel coronavirus outbreak of global health concern,2020,The Lancet,395,10223,,470,473,,68,10.1016/S0140-6736(20)30185-9,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078306786&doi=10.1016%2fS0140-6736%2820%2930185-9&partnerID=40&md5=e5310c9aa143dc878d2e516021ff6bd5,"Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, 100029, China; National Clinical Research Center for Respiratory Diseases, Beijing, China; Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China; Department of Respiratory Medicine, Capital Medical University, Beijing, China; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom; Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, United States; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing, China","Wang, C., Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, 100029, China, National Clinical Research Center for Respiratory Diseases, Beijing, China, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China, Department of Respiratory Medicine, Capital Medical University, Beijing, China; Horby, P.W., Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom; Hayden, F.G., Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, United States; Gao, G.F., National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing, China",[No abstract available],,lopinavir; ritonavir; severe acute respiratory syndrome coronavirus 2; 2019 novel coronavirus; China; Coronavirinae; coronavirus disease 2019; Coronavirus infection; disease severity; disease surveillance; disease transmission; epidemic; gene sequence; global health; health care planning; health education; human; infection control; nonhuman; Note; priority journal; public health; real time polymerase chain reaction; risk assessment; universal precaution; virus transmission; Betacoronavirus; Coronavirinae; Coronavirus infection; epidemic; global health; pneumonia; Betacoronavirus; Coronavirus; Coronavirus Infections; Disease Outbreaks; Global Health; Humans; Pneumonia,"Novel coronavirus – Thailand (ex-China). 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Atlanta, GA: US Centers for Disease Control and Prevention (2020), https://www.cdc.gov/media/releases/2020/p0121-novel-coronavirus-travel-case.html, (Accessed 24 January 2020); Chan, J.F.-W., Yuan, S., Kok, K.-H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, , published online Jan 24; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, , published online Jan 24; Leung, G.M., Hedley, A.J., Ho, L.M., The epidemiology of severe acute respiratory syndrome in the 2003 Hong Kong epidemic: an analysis of all 1755 patients (2004) Ann Intern Med, 141, pp. 662-673; Novel coronavirus (2019-nCoV) situation report - 2 (22 January 2020). 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Geneva: World Health Organization (2004), http://www.who.int/csr/sars/country/table2004_04_21/en/, (Accessed 12 January 2020); Viboud, C., Eisenstein, J., Reid, A.H., Janczewski, T.A., Morens, D.M., Taubenberger, J.K., Age- and sex-specific mortality associated with the 1918–1919 influenza pandemic in Kentucky (2013) J Infect Dis, 207, pp. 721-729; Zhong, N.S., Zheng, B.J., Li, Y.M., Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China, in February, 2003 (2003) Lancet, 362, pp. 1353-1358; Statement on the meeting of the International Health Regulations (2005) Emergency Committee regarding the outbreak of novel coronavirus (2019-nCoV). Geneva, World Health Organization (2020), https://www.who.int/news-room/detail/23-01-2020-statement-on-the-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-outbreak-of-novel-coronavirus-(2019-ncov), (Accessed 24 January 2020); Announcement from the Headquarter for novel coronavirus pneumonia prevention and control (No 1). Beijing: China National Health Commission (2020), http://www.gov.cn/xinwen/2020-01/23/content_5471751.htm, (Accessed 23 January 2020); Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected. Geneva, World Health Organization (2020), https://www.who.int/internal-publications-detail/clinical-management-of-severe-acute-respiratory-infection-when-novel-coronavirus-(ncov)-infection-is-suspected, (Accessed 22 January 2020)",,,Lancet Publishing Group,1406736,,LANCA,31986257,English,Lancet,Note,Final,Open Access,Scopus,2-s2.0-85078306786,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Lim J., Jeon S., Shin H.-Y., Kim M.J., Seong Y.M., Lee W.J., Choe K.-W., Kang Y.M., Lee B., Park S.-J.",57214877630;57201793636;57214877632;57188568542;57214877952;57204352417;7103359132;55267459000;57214877271;57214877915;,Case of the index patient who caused tertiary transmission of coronavirus disease 2019 in Korea: The application of lopinavir/ritonavir for the treatment of COVID-19 pneumonia monitored by quantitative RT-PCR,2020,Journal of Korean Medical Science,35,6, e79,,,,4,10.3346/jkms.2020.35.e79,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079360064&doi=10.3346%2fjkms.2020.35.e79&partnerID=40&md5=79193553671cffd7a4eaa0a0095eb847,"Department of Laboratory Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang, South Korea; New Horizon Cancer Institute, Myongji Hospital, Goyang, South Korea; Department of Family Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang, South Korea; Department of Internal Medicine, Myongji Hospital, Goyang, South Korea; Office of Chief Executive Officer and Chairman, Department of General Surgery, Myongji Hospital, Goyang, South Korea; Department of Infectious Diseases, Myongji Hospital, Goyang, South Korea; CancerROP, Seoul, South Korea; Department of Pulmonary and Critical Care Medicine, Myongji Hospital, Goyang, South Korea","Lim, J., Department of Laboratory Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang, South Korea; Jeon, S., New Horizon Cancer Institute, Myongji Hospital, Goyang, South Korea; Shin, H.-Y., Department of Family Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang, South Korea; Kim, M.J., Department of Laboratory Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang, South Korea; Seong, Y.M., Department of Internal Medicine, Myongji Hospital, Goyang, South Korea; Lee, W.J., Office of Chief Executive Officer and Chairman, Department of General Surgery, Myongji Hospital, Goyang, South Korea; Choe, K.-W., Department of Infectious Diseases, Myongji Hospital, Goyang, South Korea; Kang, Y.M., Department of Infectious Diseases, Myongji Hospital, Goyang, South Korea; Lee, B., CancerROP, Seoul, South Korea; Park, S.-J., Department of Pulmonary and Critical Care Medicine, Myongji Hospital, Goyang, South Korea","Since mid-December of 2019, coronavirus disease 2019 (COVID-19) has been spreading from Wuhan, China. The confirmed COVID-19 patients in South Korea are those who came from or visited China. As secondary transmissions have occurred and the speed of transmission is accelerating, there are rising concerns about community infections. The 54-year old male is the third patient diagnosed with COVID-19 in Korea. He is a worker for a clothing business and had mild respiratory symptoms and intermittent fever in the beginning of hospitalization, and pneumonia symptoms on chest computerized tomography scan on day 6 of admission. This patient caused one case of secondary transmission and three cases of tertiary transmission. Hereby, we report the clinical findings of the index patient who was the first to cause tertiary transmission outside China. Interestingly, after lopinavir/ritonavir (Kaletra, AbbVie) was administered, β-coronavirus viral loads significantly decreased and no or little coronavirus titers were observed. © 2020 The Korean Academy of Medical Sciences.",Coronavirus; COVID-19; Pneumonia; Real-time reverse-transcriptase polymerase chain reaction; Tertiary infection; Viral load,"COVID-19; cytochrome P450 3A inhibitor; lopinavir; lopinavir-ritonavir drug combination; ritonavir; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; case report; China; complication; Coronavirus infection; drug combination; genetics; human; male; middle aged; pneumonia; real time polymerase chain reaction; South Korea; virus load; virus pneumonia; Betacoronavirus; China; Coronavirus Infections; Cytochrome P-450 CYP3A Inhibitors; Drug Combinations; Humans; Lopinavir; Male; Middle Aged; Pneumonia; Pneumonia, Viral; Real-Time Polymerase Chain Reaction; Republic of Korea; Ritonavir; Viral Load","Kim, J.Y., Choe, P.G., Oh, Y., Oh, K.J., Kim, J., Park, S.J., The first case of 2019 novel coronavirus pneumonia imported into Korea from Wuhan, China: Implication for infection prevention and control measures (2020) J Korean Med Sci, 35 (5), p. e61. , PUBMED CROSSREF; Hamer, M., Kivimaki, M., Stamatakis, E., Batty, G.D., Psychological distress and infectious disease mortality in the general population (2019) Brain Behav Immun, 76, pp. 280-283. , PUBMED CROSSREF; Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med, , PUBMED CROSSREF; Rothe, C., Schunk, M., Sothmann, P., Bretzel, G., Froeschl, G., Wallrauch, C., Transmission of 2019-nCoV Infection from an asymptomatic contact in Germany (2020) N Engl J Med, , PUBMED CROSSREF; Chang, D., Lin, M., Wei, L., Xie, L., Zhu, G., Dela Cruz, C.S., Epidemiologic and clinical characteristics of novel coronavirus infections involving 13 patients outside Wuhan, China (2020) JAMA, , PUBMED CROSSREF","Park, S.-J.; Department of Pulmonary and Critical Care Medicine, Myongji Hospital, 55 Hwasu-ro 14-beon-gil, Deogyang-gu, South Korea; email: drjoseph@mjh.or.kr",,Korean Academy of Medical Science,10118934,,JKMSE,32056407,English,J. Korean Med. Sci.,Article,Final,Open Access,Scopus,2-s2.0-85079360064,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Salata C., Calistri A., Parolin C., Palù G.",6506429374;6603060311;55999300500;7005465855;,Coronaviruses: A paradigm of new emerging zoonotic diseases,2020,Pathogens and Disease,77,9, ftaa006,,,,,10.1093/femspd/ftaa006,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081104990&doi=10.1093%2ffemspd%2fftaa006&partnerID=40&md5=efdd043653d5dbe2735de25e3dca3282,"Department of Molecular Medicine, University of Padova, Via Gabelli 63, Padova, 35121, Italy","Salata, C., Department of Molecular Medicine, University of Padova, Via Gabelli 63, Padova, 35121, Italy; Calistri, A., Department of Molecular Medicine, University of Padova, Via Gabelli 63, Padova, 35121, Italy; Parolin, C., Department of Molecular Medicine, University of Padova, Via Gabelli 63, Padova, 35121, Italy; Palù, G., Department of Molecular Medicine, University of Padova, Via Gabelli 63, Padova, 35121, Italy","A novel type of coronavirus (2019-nCoV) infecting humans appeared in Wuhan, China, at the end of December 2019. Since the identification of the outbreak the infection quickly spread involving in one month more than 31,000 confirmed cases with 638 death. Molecular analysis suggest that 2019-nCoV could be originated from bats after passaging in intermediate hosts, highlighting the high zoonotic potential of coronaviruses. © FEMS 2020.",2019-nCoV; coronavirus; MERS; SARS; zoonosis,"2019 novel coronavirus; Coronavirus infection; human; priority journal; Review; virus; virus transmission; animal; bat; Betacoronavirus; China; Coronavirus infection; genetics; molecular evolution; mortality; pandemic; virology; virus pneumonia; zoonosis; COVID-19; severe acute respiratory syndrome coronavirus 2; Animals; Betacoronavirus; China; Chiroptera; Coronavirus Infections; Evolution, Molecular; Humans; Pandemics; Pneumonia, Viral; Zoonoses","Channappanavar, R., Perlman, S., Pathogenic human coronavirus infections: Causes and consequences of cytokine storm and immunopathology (2017) Semin Immunopathol, 39, pp. 529-539; Chan, J.F., Lau, S.K.P., To, K.K.W., Middle East respiratory syndrome coronavirus: Another zoonotic betacoronavirus causing SARS-like disease (2015) Clin Microbiol Rev, 28, pp. 465-522; Chan, J.F., Yuan, S., Kok, K.H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: A study of a family cluster (2020) Lancet, , pii:S0140-6736(20)30154-9; Chen, Y., Liu, Q., Guo, D., Emerging coronaviruses: Genome structure, replication, and pathogenesis (2020) J Med Virol; Cui, J., Li, F., Shi, Z.L., Origin and evolution of pathogenic coronaviruses (2019) Nat Rev Microbiol, 17, pp. 181-192; De Wit, E., Van Doremalen, N., Falzarano, D., SARS and MERS: Recent insights into emerging coronaviruses (2016) Nat Rev Microbiol, 14, pp. 523-534; (2020) Novel Coronavirus. 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Situation Update 7 February 8:00, , https://www.ecdc.europa.eu/en/cases-2019-ncov-eueea, ECDC, Accessed 7 February 2020; Goo, J., Jeong, Y., Park, Y.S., Characterization of novel monoclonal antibodies against MERS-coronavirus spike protein (2020) Virus Res, 278, p. 197863; Holmes, E.C., Rambaut, A., Andersen, K.G., Pandemics: Spend on surveillance, not prediction (2018) Nature, 558, pp. 180-182; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, , pii:S0140-6736(20)30183-5; Ji, W., Wang, W., Zhao, X., Homologous recombination within the spike glycoprotein of the newly identified coronavirus may boost cross-species transmission fromsnake to human (2020) J Med Virol; Jin, Y., Lei, C., Hu, D., Human monoclonal antibodies as candidate therapeutics against emerging viruses (2017) Front Med, 11, pp. 462-470; Kim, Y., Lee, H., Park, K., Selection and characterization of monoclonal antibodies targeting middle east respiratory syndrome coronavirus through a human synthetic fab phage display library panning (2019) Antibodies (Basel), 8. , pii: E42; Kuiken, T., Fouchier, R.A., Schutten, M., Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome (2003) Lancet, 362, pp. 263-270; Kupferschmidt, K., Study claiming new coronavirus can be transmitted by people without symptoms was flawed (2020) Science; Letko, M., Munster, V., (2020) Functional Assessment of Cell Entry and Receptor Usage for Lineage B β-coronaviruses, including 2019-nCoV, , https://www.biorxiv.org/content/10.1101/2020.01.22.915660v1, Accessed 3 February 2020; Li, Q., Guan, X., Wu, P., Early transmission dynamics inWuhan, China, of novel Coronavirus-infected pneumonia (2020) N Engl J Med; Lu, R., Zhao, X., Li, J., Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding (2020) Lancet, , pii:S0140-6736(20)30251-8; Müller, M.A., Corman, V.M., Jores, J., MERS coronavirus neutralizing antibodies in camels, Eastern Africa, 1983-1997 (2014) Emerg Infect Dis, 20, pp. 2093-2095; Nishiura, H., Jung, S.M., Linton, N.M., The extent of transmission of novel coronavirus in Wuhan, China, 2020 (2020) J Clin Med, 9. , pii: E330; Paraskevis, D., Kostaki, E.G., Magiorkinis, G., Full-genome evolutionary analysis of the novel corona virus (2019-nCoV) rejects the hypothesis of emergence as a result of a recent recombination event (2020) Infect Genet Evol, 79, p. 104212; Raj, V.S., Mou, H., Smits, S.L., Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC (2013) Nature, 495, pp. 251-254; Read, J.M., Bridgen, J.R.E., Cummings, D.A.T., (2020) Novel Coronavirus 2019-nCoV: Early Estimation of Epidemiological Parameters and Epidemic Predictions, , https://www.medrxiv.org/content/10.1101/2020.01.23.20018549v2, Accessed 3 February 2020; Rothe, C., Schunk, M., Sothmann, P., Transmission of 2019-nCoV infection from an asymptomatic contact in Germany (2020) N Engl J Med; Wan, Y., Shang, J., Graham, R., Receptor recognition by novel coronavirus fromWuhan: An analysis based on decade-long structural studies of SARS (2020) J Virol, , pii:JVI.00127-20; Wang, M., Cao, R., Zhang, L., Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro (2020) Cell Res; Severe Acute Respiratory Syndrome (SARS), , https://www.who.int/csr/sars/en/, WHO 2020a. Accessed 2 February 2020; Middle East Respiratory Syndrome Coronavirus (MERS-CoV), , https://www.who.int/health-topics/middle-east-respiratory-syndrome-coronavirus-mers#tab=tab1, WHO 2020b, Accessed 2 February 2020; Statement on the Second Meeting of the International Health Regulations (2005) Emergency Committee Regarding the Outbreak of Novel Coronavirus (2019-nCoV), , https://www.who.int/news-room/detail/30-01-2020-statement-on-the-second-meeting-of-the-international-healthregulations-(2005)-emergency-committee-regarding-theoutbreak-of-novel-coronavirus-(2019-ncov), WHO 2020c. Accessed 2 February 2020; Xiong, C., Jiang, L., Chen, Y., (2020) Volution and Variation of 2019-novel Coronavirus, , https://www.biorxiv.org/content/10.1101/2020.01.30.926477v1; Zaki, A.M., Van Boheemen, S., Bestebroer, T.M., Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia (2012) N Engl J Med, 367, pp. 1814-1820; Zhou, P., Yang, X.L., Wang, X.G., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature; Zhu, N., Zhang, D., Wang, W., ANovel Coronavirus fromPatients with Pneumonia in China, 2019 (2020) N Engl J Med","Palù, G.; Department of Molecular Medicine, University of Padova, Via Gabelli 63, Italy; email: giorgio.palu@unipd.it",,Oxford University Press,2049632X,,,32065221,English,Pathog. Dis.,Review,Final,Open Access,Scopus,2-s2.0-85081104990,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Mahase E.,57208387961;,"Coronavirus covid-19 has killed more people than SARS and MERS combined, despite lower case fatality rate",2020,BMJ (Clinical research ed.),368,,,m641,,,3,10.1136/bmj.m641,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079815357&doi=10.1136%2fbmj.m641&partnerID=40&md5=c872523f914dc43fad59230c689f4919,BMJ,"Mahase, E., BMJ",[No abstract available],,,,,,NLM (Medline),17561833,,,32071063,English,BMJ,Article,Final,Open Access,Scopus,2-s2.0-85079815357,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Glauser W.,24390498700;,"Communication, transparency key as Canada faces new coronavirus threat",2020,CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne,192,7,,E171,E172,,,10.1503/cmaj.1095846,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079800081&doi=10.1503%2fcmaj.1095846&partnerID=40&md5=e84c686533ff1ea6a24cedd7358a2bdf,"Toronto, United States","Glauser, W., Toronto, United States",[No abstract available],,,,,,NLM (Medline),14882329,,,32071113,English,CMAJ,Article,Final,Open Access,Scopus,2-s2.0-85079800081,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhu N., Zhang D., Wang W., Li X., Yang B., Song J., Zhao X., Huang B., Shi W., Lu R., Niu P., Zhan F., Ma X., Wang D., Xu W., Wu G., Gao G.F., Tan W., China Novel Coronavirus Investigating and Research Team",56992193500;57215186283;7501755105;57215200597;57214464680;23098159000;7407577416;35082078200;55662158800;7402970093;56096165800;57214469225;57199216492;57214460421;57214451930;57214440007;7403171212;57203643436;,"A novel coronavirus from patients with pneumonia in China, 2019",2020,New England Journal of Medicine,382,8,,727,733,,219,10.1056/NEJMoa2001017,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080034896&doi=10.1056%2fNEJMoa2001017&partnerID=40&md5=03ca1e66534a3ac0c28d1c42393a7717,"NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China; Department of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China; Wuhan Jinyintan Hospital, Wuhan, China; Division for Viral Disease Detection, Hubei Provincial Center for Disease Control and Prevention, Wuhan, China; Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, China","Zhu, N., NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China; Zhang, D., Wuhan Jinyintan Hospital, Wuhan, China; Wang, W., NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China; Li, X., Department of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China; Yang, B., Division for Viral Disease Detection, Hubei Provincial Center for Disease Control and Prevention, Wuhan, China; Song, J., NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China; Zhao, X., NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China; Huang, B., NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China; Shi, W., Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, China; Lu, R., NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China; Niu, P., NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China; Zhan, F., Division for Viral Disease Detection, Hubei Provincial Center for Disease Control and Prevention, Wuhan, China; Ma, X., NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China; Wang, D., NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China; Xu, W., NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China; Wu, G., NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China; Gao, G.F., NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China; Tan, W., NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; China Novel Coronavirus Investigating and Research Team","In December 2019, a cluster of patients with pneumonia of unknown cause was linked to a seafood wholesale market in Wuhan, China. A previously unknown betacoronavirus was discovered through the use of unbiased sequencing in samples from patients with pneumonia. Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily. Different from both MERS-CoV and SARS-CoV, 2019-nCoV is the seventh member of the family of coronaviruses that infect humans. Enhanced surveillance and further investigation are ongoing. Copyright © 2020 Massachusetts Medical Society.",,"adult; airway epithelium cell; Article; artificial ventilation; case report; China; clinical article; computer assisted tomography; controlled study; coronavirus disease 2019; Coronavirus infection; coughing; disease surveillance; epidemic; female; fever; human; male; middle aged; Middle East respiratory syndrome coronavirus; pneumonia; priority journal; respiratory distress; SARS coronavirus; thorax pain; transmission electron microscopy; virus detection; virus isolation; whole genome sequencing; Betacoronavirus; bronchoalveolar lavage fluid; cell culture; Coronavirus infection; diagnostic imaging; epithelium cell; genetics; isolation and purification; lung; pathology; phylogeny; respiratory system; thorax radiography; ultrastructure; virology; virus genome; virus pneumonia; COVID-19; severe acute respiratory syndrome coronavirus 2; Adult; Betacoronavirus; Bronchoalveolar Lavage Fluid; Cells, Cultured; China; Coronavirus Infections; Epithelial Cells; Female; Genome, Viral; Humans; Lung; Male; Microscopy, Electron, Transmission; Middle Aged; Phylogeny; Pneumonia, Viral; Radiography, Thoracic; Respiratory System","Gao, G.F., From “A”IV to “Z”IKV: Attacks from emerging and re-emerging pathogens (2018) Cell, 172, pp. 1157-1159; Weiss, S.R., Leibowitz, J.L., Coronavirus pathogenesis (2011) Adv Virus Res, 81, pp. 85-164; Masters, P.S., Perlman, S., Coronaviridae (2013) Fields Virology, pp. 825-858. , Knipe DM, Howley PM, eds. 6th ed. Lippincott Williams & Wilkins; Su, S., Wong, G., Shi, W., Epidemiology, genetic recombination, and pathogenesis of coronaviruses (2016) Trends Microbiol, 24, pp. 490-502; Cui, J., Li, F., Shi, Z.L., Origin and evolution of pathogenic coronaviruses (2019) Nat Rev Microbiol, 17, pp. 181-192; Zhong, N.S., Zheng, B.J., Li, Y.M., Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China, in February, 2003 (2003) Lancet, 362, pp. 1353-1358; Ksiazek, T.G., Erdman, D., Goldsmith, C.S., A novel coronavirus associated with severe acute respiratory syndrome (2003) N Engl J Med, 348, pp. 1953-1966; Drosten, C., Günther, S., Preiser, W., Identification of a novel coronavirus in patients with severe acute respiratory syndrome (2003) N Engl J Med, 348, pp. 1967-1976; Zaki, A.M., van Boheemen, S., Bestebroer, T.M., Osterhaus, A.D., Fouchier, R.A., Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia (2012) N Engl J Med, 367, pp. 1814-1820; Wong, G., Liu, W., Liu, Y., Zhou, B., Bi, Y., Gao, G.F., MERS, Sars, and Ebola: The role of super-spreaders in infectious disease (2015) Cell Host Microbe, 18, pp. 398-401; (2019) Report of Clustering Pneumonia of Unknown Etiology in Wuhan City, , http://wjw.wuhan.gov.cn/front/web/showDetail/2019123108989, Wuhan Municipal Health Commission; Liu, G.S., Li, H., Zhao, S.C., Lu, R.J., Niu, P.H., Tan, W.J., Viral and bacterial etiology of acute febrile respiratory syndrome among patients in Qinghai, China (2019) Biomed Environ Sci, 32, pp. 438-445; Jonsdottir, H.R., Dijkman, R., Coronaviruses and the human airway: A universal system for virus-host interaction studies (2016) Virol J, 13, p. 24; Palacios, G., Druce, J., Du, L., A new arenavirus in a cluster of fatal transplant-associated diseases (2008) N Engl J Med, 358, pp. 991-998; Tan, W.J., Zhao, X., Ma, X.J., A novel coronavirus genome identified in a cluster of pneumonia cases - Wuhan, China 2019−2020 China CDC Weekly 2020, 2, pp. 61-62; Armstrong, G.L., MacCannell, D.R., Taylor, J., Pathogen genomics in public health (2019) N Engl J Med, 381, pp. 2569-2580; (2020) Report of Novel Coronavirus-Infected Pneumonia in Wuhan City, , http://wjw.wuhan.gov.cn/front/web/showDetail/2020012009077, Wuhan Municipal Health Commission","Tan, W.; NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, China CDC, 155 Changbai Road, Changping District, China; email: tanwj@ivdc.chinacdc.cn",,Massachussetts Medical Society,284793,,NEJMA,31978945,English,New Engl. J. Med.,Article,Final,Open Access,Scopus,2-s2.0-85080034896,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Xu Y., Liu H., Hu K., Wang M.",57044951700;56113705500;57199837535;9238357400;,Clinical Management of Lung Cancer Patients during the Outbreak of 2019 Novel Coronavirus Disease (COVID-19),2020,Zhongguo fei ai za zhi = Chinese journal of lung cancer,23,,,,,,,10.3779/j.issn.1009-3419.2020.03.02,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079789438&doi=10.3779%2fj.issn.1009-3419.2020.03.02&partnerID=40&md5=be9bb11b666a05150471d65f685e677a,"Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730, China; Department of Thoracic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730, China; Department of Radiation Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730, China","Xu, Y., Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730, China; Liu, H., Department of Thoracic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730, China; Hu, K., Department of Radiation Oncology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730, China; Wang, M., Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730, China","【中文题目:新型冠状病毒肺炎疫情期间肺癌患者临床管理】 【中文摘要:自2019年12月底以来,湖北省武汉市陆续发现多例新型冠状病毒肺炎(简称:新冠肺炎,2019 novel coronavirus disease,COVID-19),并在全国范围内蔓延。随着新冠肺炎疫情的蔓延,肺癌患者的常规医疗受到影响。由于肺癌患者接受抗肿瘤治疗后免疫力低,合并感染后症状重,应是疫情防治的重点对象,肺癌患者对新冠肺炎的防范措施日益受到关注。复杂严峻的新冠肺炎疫情下,接受抗肿瘤治疗的肺癌患者如出现发热及呼吸道症状,更需要仔细地进行鉴别诊断,评估新冠肺炎感染的风险。对于肺癌患者,在新冠肺炎疫情期间,需要进行精细化和个体化的管理,最大程度地保护患者,有效防范新冠肺炎。】 【中文关键词:肺肿瘤;患者管理; 新型冠状病毒肺炎】.Since late December 2019, an outbreak of 2019 novel coronavirus diseases (COVID-19) in Wuhan, China has spread quickly nationwide. With the spread of COVID-19, the routine clinical diagnosis and treatment for lung cancer patients has been disturbed. Due to the systemic immunosuppressive of lung cancer patients caused by the malignancy and anticancer treatments, lung cancer patients are more susceptible to infection than healthy individuals. Furthermore, patients with cancer had poorer prognosis from infection. Lung cancer patients should be the priority group for COVID-19 prevention. The protection provisions and control measures aiming to protect lung cancer patients from COVID-19 have been increasingly concerned. During the COVID-19 outbreak period, it should be carefully differentiated for fever and respiratory symptoms for lung cancer patients receiving anti-tumor treatment, in order to evaluate the risk of COVID-19. Moreover, it is necessary to carry out meticulous and individualized clinical management for lung cancer patients to effectively protect the patients from COVID-19.",2019 novel coronavirus disease; Lung neoplasms; Patient management,"COVID-19; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; China; Coronavirus infection; disease predisposition; epidemic; human; immunocompromised patient; lung tumor; pathogenicity; patient care planning; risk; virus pneumonia; Betacoronavirus; China; Coronavirus Infections; Disease Outbreaks; Disease Susceptibility; Humans; Immunocompromised Host; Lung Neoplasms; Patient Care Planning; Pneumonia, Viral; Risk",,,,NLM (Medline),19996187,,,32077441,Chinese,Zhongguo Fei Ai Za Zhi,Article,Final,,Scopus,2-s2.0-85079789438,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhang L., Gan M., Zhang Z., Li X., Liu W., Zhu A., Sun J., Li F., Wang Y., Zhang F., Zhao J., Zhou R., Zhao J.",57215850564;57214361417;57214361950;57200135132;42861832700;57203143757;57203139620;57214361905;56590134700;57189252300;57201372305;55359175300;8584763700;,Complete genome sequences of five human coronavirus NL63 strains causing respiratory illness in hospitalized children in China,2020,Microbiology Resource Announcements,9,8, e01597-19,,,,,10.1128/MRA.01597-19,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080040500&doi=10.1128%2fMRA.01597-19&partnerID=40&md5=016e042f2a2eb02153c1d678c3117661,"Institute of Infectious Disease, Guangzhou Eighth People’s Hospital of Guangzhou Medical University, Guangzhou, China; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China","Zhang, L., Institute of Infectious Disease, Guangzhou Eighth People’s Hospital of Guangzhou Medical University, Guangzhou, China; Gan, M., State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Zhang, Z., State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Li, X., State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Liu, W., State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Zhu, A., State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Sun, J., State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Li, F., State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Wang, Y., State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Zhang, F., Institute of Infectious Disease, Guangzhou Eighth People’s Hospital of Guangzhou Medical University, Guangzhou, China; Zhao, J., State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Zhou, R., State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Zhao, J., Institute of Infectious Disease, Guangzhou Eighth People’s Hospital of Guangzhou Medical University, Guangzhou, China, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China","We report the complete genome sequences of five human coronavirus NL63 (HCoV-NL63) strains obtained using next-generation sequencing. The five HCoV-NL63 strains were obtained from hospitalized children with severe acute respiratory infection detected in Guangdong, China. This study provides several complete genomes of HCoV-NL63 and improves our understanding of HCoV-NL63 evolution in China. Copyright © 2020 Zhang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.",,virus RNA; Article; China; gene sequence; genetic variability; high throughput sequencing; hospitalized child; human; Human coronavirus NL63; nose smear; nucleotide sequence; polymerase chain reaction; respiratory tract infection; RNA extraction; Sanger sequencing; virus genome; virus strain,"van der Hoek, L., Pyrc, K., Jebbink, M.F., Vermeulen-Oost, W., Berkhout, R.J., Wolthers, K.C., Wertheim-Van Dillen, P.M., Berkhout, B., Identification of a new human coronavirus (2004) Nat Med, 10, pp. 368-373. , https://doi.org/10.1038/nm1024; van der Hoek, L., Pyrc, K., Berkhout, B., Human coronavirus NL63, a new respiratory virus (2006) FEMS Microbiol Rev, 30, pp. 760-773. , https://doi.org/10.1111/j.1574-6976.2006.00032.x; Kaiser, L., Regamey, N., Roiha, H., Deffernez, C., Frey, U., Human coronavirus NL63 associated with lower respiratory tract symptoms in early life (2005) Pediatr Infect Dis J, 24, pp. 1015-1017. , https://doi.org/10.1097/01.inf.0000183773.80217.12; Hofmann, H., Pyrc, K., van der Hoek, L., Geier, M., Berkhout, B., Pöhlmann, S., Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry (2005) Proc Natl Acad Sci U S A, 102, pp. 7988-7993. , https://doi.org/10.1073/pnas.0409465102; Kuba, K., Imai, Y., Rao, S., Gao, H., Guo, F., Guan, B., Huan, Y., Penninger, J.M., A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury (2005) Nat Med, 11, pp. 875-879. , https://doi.org/10.1038/nm1267; Reyes, G.R., Kim, J.P., Sequence-independent, single-primer amplification (SISPA) of complex DNA populations (1991) Mol Cell Probes, 5, pp. 473-481. , https://doi.org/10.1016/s0890-8508(05)80020-9; Wang, Y., Zhu, N., Li, Y., Lu, R., Wang, H., Liu, G., Zou, X., Tan, W., Metagenomic analysis of viral genetic diversity in respiratory samples from children with severe acute respiratory infection in China (2016) Clin Microbiol Infect, 22. , https://doi.org/10.1016/j.cmi.2016.01.006; Katoh, K., Rozewicki, J., Yamada, K.D., MAFFT online service: Multiple sequence alignment, interactive sequence choice and visualization (2019) Brief Bioinform, 20, pp. 1160-1166. , https://doi.org/10.1093/bib/bbx108; Tamura, K., Peterson, D., Peterson, N., Stecher, G., Nei, M., Kumar, S., MEGA5: Molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods (2011) Mol Biol Evol, 28, pp. 2731-2739. , https://doi.org/10.1093/molbev/msr121","Zhou, R.; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical UniversityChina; email: zhourong@vip.163.com",,American Society for Microbiology,2576098X,,,,English,Micro. Res. Ann,Article,Final,Open Access,Scopus,2-s2.0-85080040500,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Li X., Liu M., Zhao Q., Liu R., Zhang H., Dong M., Xu S., Zhao H., Wei S., Song Z., Chen G., Chen J.",57195443412;57212231361;57215064831;55999027000;57191292867;56763324500;35768709700;56142727200;57215037549;26021558400;57214810047;56214794800;,Preliminary Recommendations for Lung Surgery during 2019 Novel Coronavirus Disease (COVID-19) Epidemic Period,2020,Zhongguo fei ai za zhi = Chinese journal of lung cancer,23,,,,,,,10.3779/j.issn.1009-3419.2020.03.01,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079740917&doi=10.3779%2fj.issn.1009-3419.2020.03.01&partnerID=40&md5=2edf2eec0cadecacf60e45e4979d4adb,"Department of Lung Cancer Surgery, Tianjin Medical University General HospitalTianjin 300052, China","Li, X., Department of Lung Cancer Surgery, Tianjin Medical University General HospitalTianjin 300052, China; Liu, M., Department of Lung Cancer Surgery, Tianjin Medical University General HospitalTianjin 300052, China; Zhao, Q., Department of Lung Cancer Surgery, Tianjin Medical University General HospitalTianjin 300052, China; Liu, R., Department of Lung Cancer Surgery, Tianjin Medical University General HospitalTianjin 300052, China; Zhang, H., Department of Lung Cancer Surgery, Tianjin Medical University General HospitalTianjin 300052, China; Dong, M., Department of Lung Cancer Surgery, Tianjin Medical University General HospitalTianjin 300052, China; Xu, S., Department of Lung Cancer Surgery, Tianjin Medical University General HospitalTianjin 300052, China; Zhao, H., Department of Lung Cancer Surgery, Tianjin Medical University General HospitalTianjin 300052, China; Wei, S., Department of Lung Cancer Surgery, Tianjin Medical University General HospitalTianjin 300052, China; Song, Z., Department of Lung Cancer Surgery, Tianjin Medical University General HospitalTianjin 300052, China; Chen, G., Department of Lung Cancer Surgery, Tianjin Medical University General HospitalTianjin 300052, China; Chen, J., Department of Lung Cancer Surgery, Tianjin Medical University General HospitalTianjin 300052, China","【中文题目:新型冠状病毒肺炎流行期肺部手术的初步建议】 【中文摘要:2019年12月,中国确诊首例新型冠状病毒肺炎患者,疫情发展对中国乃至世界产生了巨大影响。对于肺部发现占位性病变患者的整体诊疗流程也因疫情而不能常规开展。对于胸外科医生而言,外科手术的介入时机需要慎重选择。全国的胸外科同道应根据疫情的改变及对新型冠状病毒肺炎认识的不断更新共同制定诊治流程和路径。在此,我们仅依据自己的认识提出初步建议,以供参考和进一步讨论。】 【中文关键词:新型冠状病毒肺炎;肺占位性病变;外科手术治疗】.In December 2019, China diagnosed the first patient with 2019 novel coronavirus disease (COVID-19), and the following development of the epidemic had a huge impact on China and the whole world. For patients with lung occupying lesions, the whole process of diagnosis and treatment can not be carried out as usual due to the epidemic. For thoracic surgeons, the timing of surgical intervention should be very carefully considered. All thoracic surgeons in China should work together to develop the proper procedures for the diagnosis and treatment in this special situation, and continuously update the recommendations based on epidemic changes and further understanding of COVID-19. Here, we only offer some preliminary suggestions based on our own knowledge for further reference and discussion.",2019 novel coronavirus disease (COVID-19); Lung occupying lesions,"COVID-19; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; China; Coronavirus infection; epidemic; epidemiology; human; lung disease; pathogenicity; patient care planning; thorax surgery; virus pneumonia; Betacoronavirus; China; Coronavirus Infections; Epidemics; Humans; Lung Diseases; Patient Care Planning; Pneumonia, Viral; Thoracic Surgical Procedures",,,,NLM (Medline),19996187,,,32077440,Chinese,Zhongguo Fei Ai Za Zhi,Article,Final,,Scopus,2-s2.0-85079740917,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, COVID-19 National Incident Room Surveillance Team,,"COVID-19, Australia: Epidemiology Report 3 (Reporting week ending 19:00 AEDT 15 February 2020)",2020,Communicable diseases intelligence (2018),44,,,,,,,10.33321/cdi.2020.44.15,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079789188&doi=10.33321%2fcdi.2020.44.15&partnerID=40&md5=ac2b04d90007549287e5bc1623d36646,,COVID-19 National Incident Room Surveillance Team,"This is the third epidemiological report for coronavirus disease 2019 (COVID-19), previously known as novel coronavirus (2019-nCoV), from the virus now known as SARS-CoV-2, reported in Australia as at 19:00 Australian Eastern Daylight Time [AEDT] 15 February 2020. It includes data on the COVID-19 Australian cases, the international situation and current information on the severity, transmission and spread. © Commonwealth of Australia CC BY-NC-ND.",2019-nCoV; acute respiratory disease; Australia; case definition; coronavirus disease 2019; COVID-19; epidemiology; novel coronavirus; SARS-CoV-2,"COVID-19; severe acute respiratory syndrome coronavirus 2; Australia; Betacoronavirus; Coronavirus infection; human; virus pneumonia; Australia; Betacoronavirus; Coronavirus Infections; Humans; Pneumonia, Viral",,,,NLM (Medline),22096051,,,32074480,English,Commun Dis Intell (2018),Article,Final,Open Access,Scopus,2-s2.0-85079789188,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Mahase E.,57208387961;,Coronavirus: Wales tests 90% of suspected patients in their own home,2020,BMJ (Clinical research ed.),368,,,m698,,,,10.1136/bmj.m698,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079818815&doi=10.1136%2fbmj.m698&partnerID=40&md5=432afb403ed7fb0920cae902d5aebcf2,BMJ,"Mahase, E., BMJ",[No abstract available],,,,,,NLM (Medline),17561833,,,32079577,English,BMJ,Article,Final,Open Access,Scopus,2-s2.0-85079818815,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Watts C.H., Vallance P., Whitty C.J.M.",57215019669;7103109555;57213468430;,Coronavirus: global solutions to prevent a pandemic,2020,Nature,578,7795,,363,,,,10.1038/d41586-020-00457-y,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079716703&doi=10.1038%2fd41586-020-00457-y&partnerID=40&md5=48061d9f4635c669ae0976f4689dc1f2,,"Watts, C.H.; Vallance, P.; Whitty, C.J.M.",[No abstract available],Research management; Virology,Coronavirinae; Coronavirus infection; coronavirus infection 2019; disease course; disease surveillance; disease transmission; health care facility; health care system; Letter; medical research; mortality rate; nonhuman; point of care testing; priority journal; risk factor; seasonal variation; World Health Organization; Coronavirus,,,,Nature Research,280836,,NATUA,32071448,English,Nature,Letter,Final,Open Access,Scopus,2-s2.0-85079716703,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Munster V.J., Koopmans M., van Doremalen N., van Riel D., de Wit E.",9332531900;7006736989;36009447200;6602932722;22834240700;,A novel coronavirus emerging in China - Key questions for impact assessment,2020,New England Journal of Medicine,382,8,,692,694,,31,10.1056/NEJMp2000929,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078933824&doi=10.1056%2fNEJMp2000929&partnerID=40&md5=ed48ca4a59a68d08a1fa9a4c36b54b6a,"Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, United States; Department of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands","Munster, V.J., Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, United States; Koopmans, M., Department of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands; van Doremalen, N., Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, United States; van Riel, D., Department of Viroscience, Erasmus Medical Center, Rotterdam, Netherlands; de Wit, E., Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, United States",[No abstract available],,"China; Coronavirinae; coronavirus disease 2019; Coronavirus infection; disease severity; disease transmission; health care; health care facility; health center; human; Influenza A virus; Influenza A virus (H1N1); Japan; Middle East respiratory syndrome coronavirus; Nepal; nonhuman; pandemic; pathogenicity; patient monitoring; priority journal; public health; Review; SARS coronavirus; severe acute respiratory syndrome coronavirus 2; Singapore; South Korea; Taiwan; Thailand; United States; Viet Nam; Betacoronavirus; communicable disease control; Coronavirus infection; disease notification; epidemic; health survey; mortality; pathogenicity; virology; virus pneumonia; COVID-19; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; China; Communicable Disease Control; Coronavirus Infections; Disease Notification; Disease Outbreaks; Humans; Mortality; Pneumonia, Viral; Population Surveillance","(2020) Disease Outbreak News (DONs), , https://www.who.int/csr/don/en/, Geneva: World Health Organization; de Wit, E., van Doremalen, N., Falzarano, D., Munster, V.J., SARS and MERS: Recent insights into emerging coronaviruses (2016) Nat Rev Microbiol, 14, pp. 523-534; (2020) Laboratory Testing for 2019 Novel Coronavirus (2019-nCoV) in Suspected Human Cases, , https://www.who.int/publications-detail/laboratory-testing-for-2019-novel-coronavirus-(2019-ncov)-in-suspected-human-cases, Geneva: World Health Organization; Gibbons, C.L., Mangen, M.-J.J., Plass, D., Measuring underreporting and under-ascertainment in infectious disease datasets: A comparison of methods (2014) BMC Public Health, 14, p. 147; Chowell, G., Abdirizak, F., Lee, S., Transmission characteristics of MERS and SARS in the healthcare setting: A comparative study (2015) BMC Med, 13, p. 210",,,Massachussetts Medical Society,284793,,NEJMA,31978293,English,New Engl. J. Med.,Review,Final,Open Access,Scopus,2-s2.0-85078933824,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Perlman S.,7102708317;,"Another decade, another coronavirus",2020,New England Journal of Medicine,382,8,,760,762,,20,10.1056/NEJMe2001126,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078661544&doi=10.1056%2fNEJMe2001126&partnerID=40&md5=15d1201c9edcd89466abedb60615eaad,"Department of Microbiology and Immunology, University of Iowa, Iowa City, United States","Perlman, S., Department of Microbiology and Immunology, University of Iowa, Iowa City, United States",[No abstract available],,antivirus agent; virus vaccine; 2019 novel coronavirus; airway epithelium cell; China; Coronavirinae; Coronavirus infection; disease severity; drug synthesis; Editorial; epidemic; gene sequence; human; lower respiratory tract infection; Middle East respiratory syndrome coronavirus; mortality rate; nonhuman; prevalence; priority journal; public health service; SARS coronavirus; sea food; serology; severe acute respiratory syndrome; vaccine production; virus carrier; virus cell interaction; virus detection; virus genome; virus identification; virus mutation; virus pathogenesis; virus replication; virus transmission; virus virulence; Coronavirus infection; pneumonia; China; Coronavirus; Coronavirus Infections; Humans; Pneumonia,"Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, , January 24; Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382, pp. 727-733; Zhou, P., Yang, X.-L., Wang, X.-G., Discovery of a novel coronavirus associated with the recent pneumonia outbreak in 2 humans and its potential bat origin (2020) bioRxiv, , January 23; Hui, D.S., Azhar, E.I., Kim, Y.J., Memish, Z.A., Oh, M.D., Zumla, A., Middle East respiratory syndrome coronavirus: Risk factors and determinants of primary, household, and nosocomial transmission (2018) Lancet Infect Dis, 18, pp. e217-e227; Peiris, J.S., Guan, Y., Yuen, K.Y., Severe acute respiratory syndrome (2004) Nat Med, 10, pp. S88-S97; Cheng, P.K., Wong, D.A., Tong, L.K., Viral shedding patterns of coronavirus in patients with probable severe acute respiratory syndrome (2004) Lancet, 363, pp. 1699-1700; Molecular evolution of the SARS coronavirus during the course of the SARS epidemic in China (2004) Science, 303, pp. 1666-1669; Forni, D., Cagliani, R., Clerici, M., Sironi, M., Molecular evolution of human coronavirus genomes (2017) Trends Microbiol, 25, pp. 35-48; Gu, J., Gong, E., Zhang, B., Multiple organ infection and the pathogenesis of SARS (2005) J Exp Med, 202, pp. 415-424; Sabir, J.S., Lam, T.T., Ahmed, M.M., Co-circulation of three camel coronavirus species and recombination of MERS-CoVs in Saudi Arabia (2016) Science, 351, pp. 81-84","Perlman, S.; Department of Microbiology and Immunology, University of IowaUnited States",,Massachussetts Medical Society,284793,,NEJMA,31978944,English,New Engl. J. Med.,Editorial,Final,Open Access,Scopus,2-s2.0-85078661544,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Hu S., Li Z., Lan Y., Guan J., Zhao K., Chu D., Fan G., Guo Y., Gao F., He W.",57196946337;56364739300;36554399700;56096313500;56565933600;57215581007;57211434193;57215588968;57127418300;24306126900;,MiR-10a-5p-Mediated Syndecan 1 Suppression Restricts Porcine Hemagglutinating Encephalomyelitis Virus Replication,2020,Frontiers in Microbiology,11,,105,,,,,10.3389/fmicb.2020.00105,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081224134&doi=10.3389%2ffmicb.2020.00105&partnerID=40&md5=c70ab9b2042d995aec6047223c7a1cf8,"Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China; State Key Laboratory of Genetically Engineered Veterinary Vaccines, Yebio Bioengineering Co., Ltd. of Qingdao, Qingdao, China","Hu, S., Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China; Li, Z., Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China; Lan, Y., Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China; Guan, J., Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China; Zhao, K., Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China; Chu, D., State Key Laboratory of Genetically Engineered Veterinary Vaccines, Yebio Bioengineering Co., Ltd. of Qingdao, Qingdao, China; Fan, G., State Key Laboratory of Genetically Engineered Veterinary Vaccines, Yebio Bioengineering Co., Ltd. of Qingdao, Qingdao, China; Guo, Y., State Key Laboratory of Genetically Engineered Veterinary Vaccines, Yebio Bioengineering Co., Ltd. of Qingdao, Qingdao, China; Gao, F., Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China; He, W., Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China","Porcine hemagglutinating encephalomyelitis virus (PHEV) is a single-stranded RNA coronavirus that causes nervous dysfunction in the infected hosts and leads to widespread alterations in the host transcriptome by modulating specific microRNA (miRNA) levels. MiRNAs contribute to RNA virus pathogenesis by promoting antiviral immune response, enhancing viral replication, or altering miRNA-mediated host gene regulation. Thus, exploration of the virus–miRNA interactions occurring in PHEV-infected host may lead to the identification of novel mechanisms combating the virus life cycle or pathogenesis. Here, we discovered that the expression of miR-10a-5p was constitutively up-regulated by PHEV in both the N2a cells in vitro and mice brain in vivo. Treatment with miR-10a-5p mimics allowed miR-10a-5p enrichment and resulted in a significant restriction in PHEV replication, suggesting widespread negative regulation of the RNA virus infection by miR-10a-5p. The outcomes were also evidenced by miR-10a-5p inhibitor over-expression. Luciferase reporter, quantitative real-time PCR (qRT-PCR), and western blotting analysis further showed that Syndecan 1 (SDC1), a cell surface proteoglycan associated with host defense mechanisms, acts as a target gene of miR-10a-5p during PHEV infection. Naturally, siRNA-mediated knockdown of SDC1 leads to a reduction in viral replication, implying that SDC1 expression is likely a favorable condition for viral replication. Together, the findings demonstrated that the abundant miR-10a-5p leads to downstream suppression of SDC1, and it functions as an antiviral mechanism in the PHEV-induced disease, providing a potential strategy for the prevention and treatment of PHEV infection in the future work. © Copyright © 2020 Hu, Li, Lan, Guan, Zhao, Chu, Fan, Guo, Gao and He.",antiviral mechanism; miR-10a-5p; porcine hemagglutinating encephalomyelitis virus; Syndecan 1; virus replication,,"Balasubramaniam, M., Pandhare, J., Dash, C., Are microRNAs important players in HIV-1 infection? an update (2018) Viruses, 10 (E110). , 29510515; Deng, J., Xiao, J., Ma, P., Gao, B., Gong, F., Lv, L., Manipulation of viral microRNAs as a potential antiviral strategy for the treatment of cytomegalovirus infection (2017) Viruses, 9 (E118). , 28534856; Dong, B., Lu, H., Zhao, K., Liu, W., Gao, W., Lan, Y., Identification and genetic characterization of porcine hemagglutinating encephalomyelitis virus from domestic piglets in China (2014) Arch. Virol, 159, pp. 2329-2337. , 24756345; Ellis-Connell, A.L., Iempridee, T., Xu, I., Mertz, J.E., Cellular microRNAs 200b and 429 regulate the epstein-barr virus switch between latency and lytic replication (2010) J. Virol, 84, pp. 10329-10343. , 20668090; Fan, H.X., Feng, Y.J., Zhao, X.P., He, Y.Z., Tang, H., MiR-185-5p suppresses HBV gene expression by targeting ELK1 in hepatoma carcinoma cells (2018) Life Sci, 213, pp. 9-17. , 30308183; Gao, W., Zhao, K., Zhao, C., Du, C., Ren, W., Song, D., Vomiting and wasting disease associated with hemagglutinating encephalomyelitis viruses infection in piglets in Jilin, China (2011) Virol. J, 8 (130). , 21418610; Haasnoot, J., Berkhout, B., RNAi and cellular miRNAs in Infections by Mammalian Viruses (2011) Antiviral RNAi. Methods in Molecular Biology (Methods and Protocols), 721. , van Rij R., (ed), Totowa, NJ, Humana Press; Huang, J.Y., Kang, S.T., Chen, I.T., Chang, L.K., Lin, S.S., Kou, G.H., Shrimp miR-10a is co-opted by white spot syndrome virus to increase viral gene expression and viral replication (2017) Front. Immunol, 8 (1084). , 28932224; Jia, X., Bi, Y., Li, J., Xie, Q., Yang, H., Liu, W., Cellular microRNA miR-26a suppresses replication of porcine reproductive and respiratory syndrome virus by activating innate antiviral immunity (2015) Sci. Rep, 5 (10651). , 26013676; Lee, Y.S., Dutta, A., MicroRNAs in cancer (2009) Annu. Rev. Pathol, 4, pp. 199-227; Li, Z., He, W., Lan, Y., Zhao, K., Lv, X., Lu, H., The evidence of porcine hemagglutinating encephalomyelitis virus induced nonsuppurative encephalitis as the cause of death in piglets (2016) PeerJ, 4 (e2443). , 27672502; Li, Z., Lan, Y., Zhao, K., Lv, X., Ding, N., Lu, H., miR-142-5p disrupts neuronal morphogenesis underlying porcine hemagglutinating encephalomyelitis virus infection by targeting Ulk1 (2017) Front. Cell. Infect. Microbiol, 7 (155). , 28516065; Lv, X., Zhao, K., Lan, Y., Li, Z., Ding, N., Su, J., miR-21a-5p contributes to porcine hemagglutinating encephalomyelitis virus proliferation via targeting CASK-interactive protein1 in vivo and vitro (2017) Front. Microbiol, 8 (304). , 28298907; Panoutsopoulou, K., Avgeris, M., Scorilas, A., miRNA and long non-coding RNA: molecular function and clinical value in breast and ovarian cancers (2018) Expert. Rev. Mol. Diagn, 18, pp. 963-979. , 30338716; Peng, S., Wang, J., Wei, S., Li, C., Zhou, K., Hu, J., Endogenous cellular MicroRNAs mediate antiviral defense against influenza A virus (2018) Mol. Ther. Nucleic Acids, 10, pp. 361-375. , 29499948; Rho, S., Moon, H.J., Park, S.J., Kim, H.K., Keum, H.O., Han, J.Y., Detection and genetic analysis of porcine hemagglutinating encephalomyelitis virus in South Korea (2011) Virus Genes, 42, pp. 90-96. , 21103919; Scheel, T.K., Luna, J.M., Liniger, M., Nishiuchi, E., Rozen-Gagnon, K., Shlomai, A., A broad RNA virus survey reveals both miRNA dependence and functional sequestration (2016) Cell. Host Microb, 19, pp. 409-423. , 26962949; Sun, W., Zhang, J., Chen, J., MicroRNA-520a suppresses HBV replication in HepG2.2.15 cells by inactivating AKT (2018) J. Int. Med. Res, 46, pp. 4693-4704. , 30191752; Teng, Y.H., Aquino, R.S., Park, P.W., Molecular functions of syndecan-1 in disease (2012) Matrix Biol, 31, pp. 3-16. , 22033227; Vijgen, L., Keyaerts, E., Lemey, P., Maes, P., Van Reeth, K., Nauwynck, H., Evolutionary history of the closely related group 2 coronaviruses: porcine hemagglutinating encephalomyelitis virus, bovine coronavirus, and human coronavirus OC43 (2006) J. Virol, 80, pp. 7270-7274. , 16809333; Wang, Y., Li, Y., miR-146 promotes HBV replication and expression by targeting ZEB2 (2018) Biomed. Pharmacother, 99, pp. 576-582. , 29902868; Zhu, X., He, Z., Hu, Y., Wen, W., Lin, C., Yu, J., MicroRNA-30e∗ suppresses dengue virus replication by promoting NF-kappaB-dependent IFN production (2014) PLoS Negl. Trop. Dis, 8 (e3088). , 25122182","He, W.; Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin UniversityChina; email: hewq@jlu.edu.cn",,Frontiers Media S.A.,1664302X,,,,English,Front. Microbiol.,Article,Final,Open Access,Scopus,2-s2.0-85081224134,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Li D.K.T.,7405320848;,Challenges and responsibilities of family doctors in the new global coronavirus outbreak,2020,Family Medicine and Community Health,8,1, e000333,,,,,10.1136/fmch-2020-000333,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080928626&doi=10.1136%2ffmch-2020-000333&partnerID=40&md5=f4af54311a9ffcf4e9f7dc923806707d,"Family Medical Practice, Hong Kong, Hong Kong","Li, D.K.T., Family Medical Practice, Hong Kong, Hong Kong",[No abstract available],family medicine,,,"Li, D.K.T.; Family Medical PracticeHong Kong; email: dr2318@hotmail.com",,BMJ Publishing Group,23056983,,,,English,Fam. Med. Community Health,Editorial,Final,Open Access,Scopus,2-s2.0-85080928626,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Service R.F.,57210795592;,Coronavirus epidemic snarls science worldwide,2020,Science,367,6480,,836,837,,,10.1126/science.367.6480.836,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079753489&doi=10.1126%2fscience.367.6480.836&partnerID=40&md5=5700cb1b1f65205d87d29bc543c6a0f9,,"Service, R.F.",[No abstract available],,China; coronavirus disease 2019; emergency health service; epidemic; health care access; human; nonhuman; Note; pandemic; priority journal; severe acute respiratory syndrome; virus isolation; virus transmission; Coronavirus,,"Service, R.F.",,American Association for the Advancement of Science,368075,,SCIEA,32079750,English,Sci.,Note,Final,Open Access,Scopus,2-s2.0-85079753489,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Lu R., Zhao X., Li J., Niu P., Yang B., Wu H., Wang W., Song H., Huang B., Zhu N., Bi Y., Ma X., Zhan F., Wang L., Hu T., Zhou H., Hu Z., Zhou W., Zhao L., Chen J., Meng Y., Wang J., Lin Y., Yuan J., Xie Z., Ma J., Liu W.J., Wang D., Xu W., Holmes E.C., Gao G.F., Wu G., Chen W., Shi W., Tan W.",7402970093;7407577416;57209630682;56096165800;57214464680;57214450884;7501755105;56317921900;35082078200;56992193500;35093646300;57199216492;57214469225;57196335024;57214952498;57211351750;57214457378;55255529400;57193928058;57214474354;57214459035;56681250300;57214466353;57214447872;57214453146;57214473256;57191415744;57214460421;57214451930;55535773400;7403171212;57214440007;57214458406;55662158800;57203643436;,Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding,2020,The Lancet,395,10224,,565,574,,120,10.1016/S0140-6736(20)30251-8,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078741591&doi=10.1016%2fS0140-6736%2820%2930251-8&partnerID=40&md5=d171d93b32431ee2172079e77d395488,"NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China; Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai'an, China; Division for Viral Disease Detection, Hubei Provincial Center for Disease Control and Prevention, Wuhan, China; BGI PathoGenesis Pharmaceutical Technology, Shenzhen, China; Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, China; Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China; Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), Chinese Academy of Sciences, Beijing, China; Central Theater, People's Liberation Army General Hospital, Wuhan, China; Key Laboratory of Laboratory Medicine, Ministry of Education, and Zhejiang Provincial Key Laboratory of Medical Genetics, Institute of Medical Virology, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, China; Marie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and School of Medical Sciences, University of Sydney, Sydney, NSW, Australia; The First Affiliated Hospital of Shandong First Medical University (Shandong Provincial Qianfoshan Hospital), Jinan, China; Center for Biosafety Mega-Science, Chinese Academy of Sciences, Beijing, China","Lu, R., NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China; Zhao, X., NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China; Li, J., Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai'an, China; Niu, P., NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China; Yang, B., Division for Viral Disease Detection, Hubei Provincial Center for Disease Control and Prevention, Wuhan, China; Wu, H., BGI PathoGenesis Pharmaceutical Technology, Shenzhen, China; Wang, W., NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China; Song, H., Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, China; Huang, B., NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China; Zhu, N., NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China; Bi, Y., Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), Chinese Academy of Sciences, Beijing, China; Ma, X., NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China; Zhan, F., Division for Viral Disease Detection, Hubei Provincial Center for Disease Control and Prevention, Wuhan, China; Wang, L., Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), Chinese Academy of Sciences, Beijing, China; Hu, T., Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai'an, China; Zhou, H., Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai'an, China; Hu, Z., Central Theater, People's Liberation Army General Hospital, Wuhan, China; Zhou, W., NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China; Zhao, L., NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China; Chen, J., Key Laboratory of Laboratory Medicine, Ministry of Education, and Zhejiang Provincial Key Laboratory of Medical Genetics, Institute of Medical Virology, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, China; Meng, Y., NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China; Wang, J., NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China; Lin, Y., BGI PathoGenesis Pharmaceutical Technology, Shenzhen, China; Yuan, J., BGI PathoGenesis Pharmaceutical Technology, Shenzhen, China; Xie, Z., BGI PathoGenesis Pharmaceutical Technology, Shenzhen, China; Ma, J., BGI PathoGenesis Pharmaceutical Technology, Shenzhen, China; Liu, W.J., NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China; Wang, D., NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China; Xu, W., NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China; Holmes, E.C., Marie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and School of Medical Sciences, University of Sydney, Sydney, NSW, Australia; Gao, G.F., NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China, Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), Chinese Academy of Sciences, Beijing, China; Wu, G., NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China; Chen, W., BGI PathoGenesis Pharmaceutical Technology, Shenzhen, China; Shi, W., Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai'an, China, The First Affiliated Hospital of Shandong First Medical University (Shandong Provincial Qianfoshan Hospital), Jinan, China; Tan, W., NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China, Central Theater, People's Liberation Army General Hospital, Wuhan, China, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Beijing, China","Background: In late December, 2019, patients presenting with viral pneumonia due to an unidentified microbial agent were reported in Wuhan, China. A novel coronavirus was subsequently identified as the causative pathogen, provisionally named 2019 novel coronavirus (2019-nCoV). As of Jan 26, 2020, more than 2000 cases of 2019-nCoV infection have been confirmed, most of which involved people living in or visiting Wuhan, and human-to-human transmission has been confirmed. Methods: We did next-generation sequencing of samples from bronchoalveolar lavage fluid and cultured isolates from nine inpatients, eight of whom had visited the Huanan seafood market in Wuhan. Complete and partial 2019-nCoV genome sequences were obtained from these individuals. Viral contigs were connected using Sanger sequencing to obtain the full-length genomes, with the terminal regions determined by rapid amplification of cDNA ends. Phylogenetic analysis of these 2019-nCoV genomes and those of other coronaviruses was used to determine the evolutionary history of the virus and help infer its likely origin. Homology modelling was done to explore the likely receptor-binding properties of the virus. Findings: The ten genome sequences of 2019-nCoV obtained from the nine patients were extremely similar, exhibiting more than 99·98% sequence identity. Notably, 2019-nCoV was closely related (with 88% identity) to two bat-derived severe acute respiratory syndrome (SARS)-like coronaviruses, bat-SL-CoVZC45 and bat-SL-CoVZXC21, collected in 2018 in Zhoushan, eastern China, but were more distant from SARS-CoV (about 79%) and MERS-CoV (about 50%). Phylogenetic analysis revealed that 2019-nCoV fell within the subgenus Sarbecovirus of the genus Betacoronavirus, with a relatively long branch length to its closest relatives bat-SL-CoVZC45 and bat-SL-CoVZXC21, and was genetically distinct from SARS-CoV. Notably, homology modelling revealed that 2019-nCoV had a similar receptor-binding domain structure to that of SARS-CoV, despite amino acid variation at some key residues. Interpretation: 2019-nCoV is sufficiently divergent from SARS-CoV to be considered a new human-infecting betacoronavirus. Although our phylogenetic analysis suggests that bats might be the original host of this virus, an animal sold at the seafood market in Wuhan might represent an intermediate host facilitating the emergence of the virus in humans. Importantly, structural analysis suggests that 2019-nCoV might be able to bind to the angiotensin-converting enzyme 2 receptor in humans. The future evolution, adaptation, and spread of this virus warrant urgent investigation. Funding: National Key Research and Development Program of China, National Major Project for Control and Prevention of Infectious Disease in China, Chinese Academy of Sciences, Shandong First Medical University. © 2020 Elsevier Ltd",,"angiotensin converting enzyme 2; complementary DNA; COVID-19; severe acute respiratory syndrome coronavirus 2; virus DNA; virus receptor; 2019 novel coronavirus; Article; Betacoronavirus; bronchoalveolar lavage fluid; China; clinical article; controlled study; epidemiological data; genomics; high throughput sequencing; hospital patient; human; human cell; nonhuman; phylogeny; priority journal; receptor binding; Sanger sequencing; SARS coronavirus; sequence homology; virus genome; virus isolation; virus pneumonia; virus transmission; Betacoronavirus; Coronavirus infection; disease carrier; genetics; genomics; metabolism; procedures; sequence alignment; virology; virus genome; virus pneumonia; Betacoronavirus; Bronchoalveolar Lavage Fluid; China; Coronavirus Infections; Disease Reservoirs; DNA, Viral; Genome, Viral; Genomics; High-Throughput Nucleotide Sequencing; Humans; Phylogeny; Pneumonia, Viral; Receptors, Virus; Sequence Alignment","Su, S., Wong, G., Shi, W., Epidemiology, genetic recombination, and pathogenesis of coronaviruses (2016) Trends Microbiol, 24, pp. 490-502; Cavanagh, D., Coronavirus avian infectious bronchitis virus (2007) Vet Res, 38, pp. 281-297; Ismail, M.M., Tang, A.Y., Saif, Y.M., Pathogenicity of turkey coronavirus in turkeys and chickens (2003) Avian Dis, 47, pp. 515-522; Zhou, P., Fan, H., Lan, T., Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin (2018) Nature, 556, pp. 255-258; Peiris, J.S., Guan, Y., Yuen, K.Y., Severe acute respiratory syndrome (2004) Nat Med, 10, pp. S88-S97; Chan-Yeung, M., Xu, R.H., SARS: epidemiology (2003) Respirology, 8, pp. S9-S14; Zaki, A.M., van Boheemen, S., Bestebroer, T.M., Osterhaus, A.D., Fouchier, R.A., Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia (2012) N Engl J Med, 367, pp. 1814-1820; 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Niu, P., Shen, J., Zhu, N., Lu, R., Tan, W., Two-tube multiplex real-time reverse transcription PCR to detect six human coronaviruses (2016) Virol Sin, 31, pp. 85-88; Li, H., Durbin, R., Fast and accurate short read alignment with Burrows-Wheeler transform (2009) Bioinformatics, 25, pp. 1754-1760; Zhao, Y., Tang, H., Ye, Y., RAPSearch2: a fast and memory-efficient protein similarity search tool for next-generation sequencing data (2012) Bioinformatics, 28, pp. 125-126; Nurk, S., Bankevich, A., Antipov, D., Assembling genomes and mini-metagenomes from highly chimeric reads (2013) Research in computational molecular biology (RECOMB 2013): lecture notes in computer science, 7821, pp. 158-170. , M Deng R Jiang F Sun X Zhang Springer Berlin; Pan, M., Gao, R., Lv, Q., Human infection with a novel, highly pathogenic avian influenza A (H5N6) virus: virological and clinical findings (2016) J Infect, 72, pp. 52-59; Marchler-Bauer, A., Bo, Y., Han, L., CDD/SPARCLE: functional classification of proteins via subfamily domain architectures (2017) Nucleic Acids Res, 45, pp. D200-D203; Lole, K.S., Bollinger, R.C., Paranjape, R.S., Full-length human immunodeficiency virus type 1 genomes from subtype C-infected seroconverters in India, with evidence of intersubtype recombination (1999) J Virol, 73, pp. 152-160; Nakamura, T., Yamada, K.D., Tomii, K., Katoh, K., Parallelization of MAFFT for large-scale multiple sequence alignments (2018) Bioinformatics, 34, pp. 2490-2492; Stamatakis, A., RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies (2014) Bioinformatics, 30, pp. 1312-1313; Hu, D., Zhu, C., Ai, L., Genomic characterization and infectivity of a novel SARS-like coronavirus in Chinese bats (2018) Emerg Microbes Infect, 7, p. 154; Li, F., Structure, function, and evolution of coronavirus spike proteins (2016) Annu Rev Virol, 3, pp. 237-261; Lu, G., Wang, Q., Gao, G.F., Bat-to-human: spike features determining ‘host jump’ of coronaviruses SARS-CoV, MERS-CoV, and beyond (2015) Trends Microbiol, 23, pp. 468-478; Wang, Q., Wong, G., Lu, G., Yan, J., Gao, G.F., MERS-CoV spike protein: targets for vaccines and therapeutics (2016) Antiviral Res, 133, pp. 165-177; He, Y., Zhou, Y., Liu, S., Receptor-binding domain of SARS-CoV spike protein induces highly potent neutralizing antibodies: implication for developing subunit vaccine (2004) Biochem Biophys Res Commun, 324, pp. 773-781; Li, F., Evidence for a common evolutionary origin of coronavirus spike protein receptor-binding subunits (2012) J Virol, 86, pp. 2856-2858; Li, F., Li, W., Farzan, M., Harrison, S.C., Structure of SARS coronavirus spike receptor-binding domain complexed with receptor (2005) Science, 309, pp. 1864-1868; Lu, G., Hu, Y., Wang, Q., Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26 (2013) Nature, 500, pp. 227-231; Wang, N., Shi, X., Jiang, L., Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4 (2013) Cell Res, 23, pp. 986-993; Wang, Q., Qi, J., Yuan, Y., Bat origins of MERS-CoV supported by bat coronavirus HKU4 usage of human receptor CD26 (2014) Cell Host Microbe, 16, pp. 328-337; Waterhouse, A., Bertoni, M., Bienert, S., SWISS-MODEL: homology modelling of protein structures and complexes (2018) Nucleic Acids Res, 46, pp. W296-W303; Prabakaran, P., Gan, J., Feng, Y., Structure of severe acute respiratory syndrome coronavirus receptor-binding domain complexed with neutralizing antibody (2006) J Biol Chem, 281, pp. 15829-15836; Guan, Y., Zheng, B.J., He, Y.Q., Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China (2003) Science, 302, pp. 276-278; Alagaili, A.N., Briese, T., Mishra, N., Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia (2014) mBio, 5, pp. e00884-e00914; Zhou, P., Yang, X.-L., Wang, X.-G., Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin (2020) bioRxiv, , published online Jan 23","Tan, W.; NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and PreventionChina; email: tanwj@ivdc.chinacdc.cn",,Lancet Publishing Group,1406736,,LANCA,32007145,English,Lancet,Article,Final,Open Access,Scopus,2-s2.0-85078741591,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, [No author name available],[No author id available],Advice and guidance on coronavirus,2020,The Veterinary record,186,7,,201,,,,10.1136/vr.m669,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079778942&doi=10.1136%2fvr.m669&partnerID=40&md5=7e1dea6c6118441e2d18fca3b7cb215a,,,[No abstract available],,,,,,NLM (Medline),20427670,,,32086404,English,Vet. Rec.,Article,Final,,Scopus,2-s2.0-85079778942,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Park W.B., Kwon N.-J., Choi S.-J., Kang C.K., Choe P.G., Kim J.Y., Yun J., Lee G.-W., Seong M.-W., Kim N.J., Seo J.-S., Oh M.-D.",57213653096;24450672000;55915371600;55808491400;15070608400;57211142178;57215111622;57215053297;12242712000;57213117803;57215059064;7201600302;,Virus isolation from the first patient with SARS-CoV-2 in Korea,2020,Journal of Korean Medical Science,35,7, e84,,,,,10.3346/jkms.2020.35.e84,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079775225&doi=10.3346%2fjkms.2020.35.e84&partnerID=40&md5=7cd7c19abea81c4263a42615688f0780,"Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea; Laboratory of Infection and Immunity, Seoul National University Hospital Biomedical Research Institute, Seoul, South Korea; Macrogen Inc., Seoul, South Korea; Department of Internal Medicine, Incheon Medical Center, Incheon, South Korea; Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, South Korea; Precision Medicine Center, Seoul National University Bundang Hospital, Seongnam, South Korea","Park, W.B., Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, Laboratory of Infection and Immunity, Seoul National University Hospital Biomedical Research Institute, Seoul, South Korea; Kwon, N.-J., Macrogen Inc., Seoul, South Korea; Choi, S.-J., Laboratory of Infection and Immunity, Seoul National University Hospital Biomedical Research Institute, Seoul, South Korea; Kang, C.K., Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea; Choe, P.G., Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea; Kim, J.Y., Department of Internal Medicine, Incheon Medical Center, Incheon, South Korea; Yun, J., Macrogen Inc., Seoul, South Korea; Lee, G.-W., Macrogen Inc., Seoul, South Korea; Seong, M.-W., Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, South Korea; Kim, N.J., Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, Laboratory of Infection and Immunity, Seoul National University Hospital Biomedical Research Institute, Seoul, South Korea; Seo, J.-S., Macrogen Inc., Seoul, South Korea, Precision Medicine Center, Seoul National University Bundang Hospital, Seongnam, South Korea; Oh, M.-D., Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, Laboratory of Infection and Immunity, Seoul National University Hospital Biomedical Research Institute, Seoul, South Korea",Novel coronavirus (SARS-CoV-2) is found to cause a large outbreak started from Wuhan since December 2019 in China and SARS-CoV-2 infections have been reported with epidemiological linkage to China in 25 countries until now. We isolated SARS-CoV-2 from the oropharyngeal sample obtained from the patient with the first laboratory-confirmed SARS-CoV-2 infection in Korea. Cytopathic effects of SARS-CoV-2 in the Vero cell cultures were confluent 3 days after the first blind passage of the sample. Coronavirus was confirmed with spherical particle having a fringe reminiscent of crown on transmission electron microscopy. Phylogenetic analyses of whole genome sequences showed that it clustered with other SARS-CoV-2 reported from Wuhan. © 2020 The Korean Academy of Medical Sciences.,"2019 Novel Coronavirus; Culture; Korea; Microscopy, Electron; Phylogeny","COVID-19; severe acute respiratory syndrome coronavirus 2; adult; Betacoronavirus; case report; Coronavirus infection; female; genetics; human; isolation and purification; oropharynx; phylogeny; South Korea; transmission electron microscopy; virology; virus pneumonia; whole genome sequencing; Adult; Betacoronavirus; Coronavirus Infections; Female; Humans; Microscopy, Electron, Transmission; Oropharynx; Phylogeny; Pneumonia, Viral; Republic of Korea; Whole Genome Sequencing","Tyrrell, D.A., Bynoe, M.L., Cultivation of a novel type of common-cold virus in organ cultures (1965) BMJ, 1 (5448), pp. 1467-1470; (2020) Coronavirus disease 2019, , https://www.who.int/emergencies/diseases/novel-coronavirus-2019, Updated 2020. Accessed February 15; Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med; Ksiazek, T.G., Erdman, D., Goldsmith, C.S., Zaki, S.R., Peret, T., Emery, S., A novel coronavirus associated with severe acute respiratory syndrome (2003) N Engl J Med, 348 (20), pp. 1953-1966; Park, W.B., Kwon, N.J., Choe, P.G., Choi, S.J., Oh, H.S., Lee, S.M., Isolation of Middle East respiratory syndrome coronavirus from a patient of the 2015 Korean outbreak (2016) J Korean Med Sci, 31 (2), pp. 315-320; Kim, J.Y., Choe, P.G., Oh, Y., Oh, K.J., Kim, J., Park, S.J., The first case of 2019 novel coronavirus pneumonia imported into Korea from Wuhan, China: implication for infection prevention and control measures (2020) J Korean Med Sci, 35 (5); Graham, L., Orenstein, J.M., Processing tissue and cells for transmission electron microscopy in diagnostic pathology and research (2007) Nat Protoc, 2 (10), pp. 2439-2450; Rutvisuttinunt, W., Chinnawirotpisan, P., Simasathien, S., Shrestha, S.K., Yoon, I.K., Klungthong, C., Simultaneous and complete genome sequencing of influenza A and B with high coverage by Illumina MiSeq Platform (2013) J Virol Methods, 193 (2), pp. 394-404; Rutvisuttinunt, W., Chinnawirotpisan, P., Thaisomboonsuk, B., Rodpradit, P., Ajariyakhajorn, C., Manasatienkij, W., Viral subpopulation diversity in influenza virus isolates compared to clinical specimens (2015) J Clin Virol, 68, pp. 16-23; Rutvisuttinunt, W., Klungthong, C., Thaisomboonsuk, B., Chinnawirotpisan, P., Ajariyakhajorn, C., Manasatienkij, W., Retrospective use of next-generation sequencing reveals the presence of Enteroviruses in acute influenza-like illness respiratory samples collected in South/South-East Asia during 2010-2013 (2017) J Clin Virol, 94, pp. 91-99; Li, H., Durbin, R., Fast and accurate short read alignment with Burrows-Wheeler transform (2009) Bioinformatics, 25 (14), pp. 1754-1760; Li, H., A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data (2011) Bioinformatics, 27 (21), pp. 2987-2993; Katoh, K., Standley, D.M., MAFFT multiple sequence alignment software version 7: improvements in performance and usability (2013) Mol Biol Evol, 30 (4), pp. 772-780; Kumar, S., Stecher, G., Li, M., Knyaz, C., Tamura, K., MEGA X: molecular evolutionary genetics analysis across computing platforms (2018) Mol Biol Evol, 35 (6), pp. 1547-1549","Oh, M.-D.; Department of Internal Medicine, Seoul National University College of Medicine, 101 Daehak-ro, South Korea; email: mdohmd@snu.ac.kr",,Korean Academy of Medical Science,10118934,,JKMSE,32080990,English,J. Korean Med. Sci.,Article,Final,Open Access,Scopus,2-s2.0-85079775225,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Kim J.Y., Ko J.-H., Kim Y., Kim Y.-J., Kim J.-M., Chung Y.-S., Kim H.M., Han M.-G., Kim S.Y., Chin B.S.",57211142178;55804188300;56066688300;7410198066;57192934192;57203291955;57007421900;47161240000;57213778426;7102658932;,Viral load kinetics of SARS-CoV-2 infection in first two patients in Korea,2020,Journal of Korean Medical Science,35,7, e86,,,,2,10.3346/jkms.2020.35.e86,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079746130&doi=10.3346%2fjkms.2020.35.e86&partnerID=40&md5=21330a8cdef2be80ef3986b67224ce12,"Division of Infectious Diseases, Department of Internal Medicine, Incheon Medical Center, Incheon, South Korea; Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; Department of Internal Medicine, National Medical Center, Seoul, South Korea; Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; Division of Viral Diseases, Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control and oPrevention, Cheongju, South Korea; Department of Laboratory Medicine, National Medical Center, Seoul, South Korea","Kim, J.Y., Division of Infectious Diseases, Department of Internal Medicine, Incheon Medical Center, Incheon, South Korea; Ko, J.-H., Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; Kim, Y., Department of Internal Medicine, National Medical Center, Seoul, South Korea; Kim, Y.-J., Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; Kim, J.-M., Division of Viral Diseases, Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control and oPrevention, Cheongju, South Korea; Chung, Y.-S., Division of Viral Diseases, Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control and oPrevention, Cheongju, South Korea; Kim, H.M., Division of Viral Diseases, Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control and oPrevention, Cheongju, South Korea; Han, M.-G., Division of Viral Diseases, Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control and oPrevention, Cheongju, South Korea; Kim, S.Y., Department of Laboratory Medicine, National Medical Center, Seoul, South Korea; Chin, B.S., Department of Internal Medicine, National Medical Center, Seoul, South Korea","As of February 2020, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak started in China in December 2019 has been spreading in many countries in the world. With the numbers of confirmed cases are increasing, information on the epidemiologic investigation and clinical manifestation have been accumulated. However, data on viral load kinetics in confirmed cases are lacking. Here, we present the viral load kinetics of the first two confirmed patients with mild to moderate illnesses in Korea in whom distinct viral load kinetics are shown. This report suggests that viral load kinetics of SARS-CoV-2 may be different from that of previously reported other coronavirus infections such as SARS-CoV. © 2020 The Korean Academy of Medical Sciences.",2019-nCoV; Coronavirus; COVID-19; SARS-CoV-2; Viral Load Kinetics,"COVID-19; severe acute respiratory syndrome coronavirus 2; adult; Betacoronavirus; case report; Coronavirus infection; female; human; kinetics; male; middle aged; pathogenicity; severity of illness index; virology; virus load; virus pneumonia; Adult; Betacoronavirus; Coronavirus Infections; Female; Humans; Kinetics; Male; Middle Aged; Pneumonia, Viral; Severity of Illness Index; Viral Load","Gorbalenya, A.E., Baker, S.C., Baric, R.S., de Groot, R.J., Drosten, C., Gulyaeva, A.A., Severe acute respiratory syndrome-related coronavirus: the species and its viruses -a statement of the Coronavirus Study Group (2020), bioRxiv. Forthcoming; Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Early Transmission Dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med, , NEJMoa2001316; Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med., , Forthcoming; (2020) Statement on the second meeting of the International Health Regulations (2005) Emergency Committee regarding the outbreak of novel coronavirus (2019-nCoV), , https://www.who.int/news-room/detail/30-01-2020-statement-on-the-second-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-outbreak-of-novel-coronavirus-(2019-ncov), Updated 2020. Accessed February 13; (2020) Laboratory testing for 2019 novel coronavirus (2019-nCoV) in suspected human cases, , https://www.who.int/publications-detail/laboratory-testing-for-2019-novel-coronavirus-in-suspected-human-cases-20200117, Updated 2020. Accessed February 13; Corman, V.M., Landt, O., Kaiser, M., Molenkamp, R., Meijer, A., Chu, D.K., Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR (2020) Euro Surveill, 25 (3), p. 2000045; Kim, J.Y., Choe, P.G., Oh, Y., Oh, K.J., Kim, J., Park, S.J., the first case of 2019 novel coronavirus pneumonia imported into Korea from Wuhan, China: implication for infection prevention and control measures (2020) J Korean Med Sci, 35 (5); Peiris, J.S., Chu, C.M., Cheng, V.C., Chan, K.S., Hung, I.F., Poon, L.L., Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study (2003) Lancet, 361 (9371), pp. 1767-1772; Huh, H.J., Ko, J.H., Kim, Y.E., Park, C.H., Hong, G., Choi, R., Importance of specimen type and quality in diagnosing middle east respiratory syndrome (2017) Ann Lab Med, 37 (1), pp. 81-83","Chin, B.S.; Department of Internal Medicine, National Medical Center, 245 Eulji-ro, South Korea; email: moberrer@nmc.or.kr",,Korean Academy of Medical Science,10118934,,JKMSE,32080991,English,J. Korean Med. Sci.,Article,Final,Open Access,Scopus,2-s2.0-85079746130,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Kim J.Y.,57211142178;,Letter to the editor: Case of the index patient who caused tertiary transmission of coronavirus disease 2019 in Korea: The application of lopinavir/ritonavir for the treatment of COVID-19 pneumonia monitored by quantitative RT-PCR,2020,Journal of Korean Medical Science,35,7, e88,,,,,10.3346/jkms.2020.35.e88,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079793104&doi=10.3346%2fjkms.2020.35.e88&partnerID=40&md5=d19073fb42954950e0df791c26b7c2b5,"Division of Infectious Diseases, Department of Internal Medicine, Incheon Medical Center, Incheon, South Korea","Kim, J.Y., Division of Infectious Diseases, Department of Internal Medicine, Incheon Medical Center, Incheon, South Korea",[No abstract available],,lopinavir; ritonavir; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; Coronavirinae; human; pneumonia; reverse transcription polymerase chain reaction; South Korea; Betacoronavirus; Coronavirus; Humans; Lopinavir; Pneumonia; Republic of Korea; Reverse Transcriptase Polymerase Chain Reaction; Ritonavir,"Lim, J., Jeon, S., Shin, H.Y., Kim, M.J., Seong, Y.M., Lee, W.J., Case of the index patient who caused tertiary transmission of Coronavirus disease 2019 in Korea: the application of lopinavir/ritonavir for the treatment of COVID-19 pneumonia monitored by quantitative RT-PCR (2020) J Korean Med Sci, 35 (6); Chu, C.M., Cheng, V.C., Hung, I.F., Wong, M.M., Chan, K.H., Chan, K.S., Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings (2004) Thorax, 59 (3), pp. 252-256; Chan, K.S., Lai, S.T., Chu, C.M., Tsui, E., Tam, C.Y., Wong, M.M., Treatment of severe acute respiratory syndrome with lopinavir/ritonavir: a multicentre retrospective matched cohort study (2003) Hong Kong Med J, 9 (6), pp. 399-406; Kim, J.Y., Choe, P.G., Oh, Y., Oh, K.J., Kim, J., Park, S.J., The first case of 2019 novel coronavirus pneumonia imported into Korea from Wuhan, China: implication for infection prevention and control measures (2020) J Korean Med Sci, 35 (5)","Kim, J.Y.; Division of Infectious Diseases, Department of Internal Medicine, Incheon Medical Center, 217 Bangchuk-ro, South Korea; email: kjykey@gmail.com",,Korean Academy of Medical Science,10118934,,JKMSE,32080992,English,J. Korean Med. Sci.,Letter,Final,Open Access,Scopus,2-s2.0-85079793104,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Lim J., Jeon S., Shin H.-Y., Kim M.J., Seong Y.M., Lee W.J., Choe K.-W., Kang Y.M., Lee B., Park S.-J.",57214877630;57201793636;57214877632;57188568542;57214877952;57204352417;7103359132;55267459000;57214877271;57214877915;,The Author's response: Case of the index patient who caused tertiary transmission of coronavirus disease 2019 in Korea: The Application of lopinavir/ritonavir for the treatment of COVID-19 pneumonia monitored by quantitative RT-PCR,2020,Journal of Korean Medical Science,35,7, e89,,,,,10.3346/jkms.2020.35.e89,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079742900&doi=10.3346%2fjkms.2020.35.e89&partnerID=40&md5=db8a8ec21b00c98df3c232ddebef98de,"Department of Laboratory Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang, South Korea; New Horizon Cancer Institute, Myongji Hospital, Goyang, South Korea; Department of Family Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang, South Korea; Department of Internal Medicine, Myongji Hospital, Goyang, South Korea; Office of Chief Executive Officer and Chairman, Department of General Surgery, Myongji Hospital, Goyang, South Korea; Department of Infectious Diseases, Myongji Hospital, Goyang, South Korea; CancerROP, Seoul, South Korea; Department of Pulmonary and Critical Care Medicine, Myongji Hospital, Goyang, South Korea","Lim, J., Department of Laboratory Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang, South Korea; Jeon, S., New Horizon Cancer Institute, Myongji Hospital, Goyang, South Korea; Shin, H.-Y., Department of Family Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang, South Korea; Kim, M.J., Department of Laboratory Medicine, Myongji Hospital, Hanyang University College of Medicine, Goyang, South Korea; Seong, Y.M., Department of Internal Medicine, Myongji Hospital, Goyang, South Korea; Lee, W.J., Office of Chief Executive Officer and Chairman, Department of General Surgery, Myongji Hospital, Goyang, South Korea; Choe, K.-W., Department of Infectious Diseases, Myongji Hospital, Goyang, South Korea; Kang, Y.M., Department of Infectious Diseases, Myongji Hospital, Goyang, South Korea; Lee, B., CancerROP, Seoul, South Korea; Park, S.-J., Department of Pulmonary and Critical Care Medicine, Myongji Hospital, Goyang, South Korea",[No abstract available],,lopinavir; ritonavir; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; Coronavirinae; human; pneumonia; reverse transcription polymerase chain reaction; South Korea; Betacoronavirus; Coronavirus; Humans; Lopinavir; Pneumonia; Republic of Korea; Reverse Transcriptase Polymerase Chain Reaction; Ritonavir,"Lim, J., Jeon, S., Shin, H.Y., Kim, M.J., Seong, Y.M., Lee, W.J., Case of the index patient who caused tertiary transmission of Coronavirus disease 2019 in Korea: the application of lopinavir/ritonavir for the treatment of COVID-19 pneumonia monitored by quantitative RT-PCR (2020) J Korean Med Sci, 35 (6); Li, G., Clercq, E.D., (2020) Therapeutic options for the 2019 novel coronavirus (2019-nCoV), , Nat Rev Drug Discov. Forthcoming; Wang, M., Cao, R., Zhang, L., Yang, X., Liu, J., Xu, M., Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro (2020) Cell Res., , Forthcoming","Park, S.-J.; Department of Pulmonary and Critical Care Medicine, Myongji Hospital, 55 Hwasu-ro 14-beon-gil, South Korea; email: drjoseph@mjh.or.kr",,Korean Academy of Medical Science,10118934,,JKMSE,32080993,English,J. Korean Med. Sci.,Letter,Final,Open Access,Scopus,2-s2.0-85079742900,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Huneycutt B., Lurie N., Rotenberg S., Wilder R., Hatchett R.",57214219554;7006649471;57214224185;57214218623;7003775995;,Finding equipoise: CEPI revises its equitable access policy,2020,Vaccine,38,9,,2144,2148,,,10.1016/j.vaccine.2019.12.055,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078413358&doi=10.1016%2fj.vaccine.2019.12.055&partnerID=40&md5=0666b15d1a1c0e8e054cb2c847c9dc95,"Coalition for Epidemic Preparedness Innovations, 1901 Pennsylvania Ave NW, Suite 1003, Washington, DC, 20006, United States; FasterCures, a Center of the Milken Institute, 730 15th St NW, Washington, DC, 20005, United States; Georgetown University, Department of International Health, 3700 Reservoir Road NW, Washington, DC, 20057, United States","Huneycutt, B., Coalition for Epidemic Preparedness Innovations, 1901 Pennsylvania Ave NW, Suite 1003, Washington, DC, 20006, United States, FasterCures, a Center of the Milken Institute, 730 15th St NW, Washington, DC, 20005, United States; Lurie, N., Coalition for Epidemic Preparedness Innovations, 1901 Pennsylvania Ave NW, Suite 1003, Washington, DC, 20006, United States; Rotenberg, S., Georgetown University, Department of International Health, 3700 Reservoir Road NW, Washington, DC, 20057, United States; Wilder, R., Coalition for Epidemic Preparedness Innovations, 1901 Pennsylvania Ave NW, Suite 1003, Washington, DC, 20006, United States; Hatchett, R., Coalition for Epidemic Preparedness Innovations, 1901 Pennsylvania Ave NW, Suite 1003, Washington, DC, 20006, United States","Launched at Davos in January 2017 with funding from sovereign investors and philanthropic institutions, the Coalition for Epidemic Preparedness Innovations (CEPI) is an innovative partnership between public, private, philanthropic, and civil organisations whose mission is to stimulate, finance and co-ordinate vaccine development against diseases with epidemic potential in cases where market incentives fail. As of December 2019, CEPI has committed to investing up to $706 million in vaccine development. This includes 19 vaccine candidates against its priority pathogens (Lassa fever virus, Middle East respiratory syndrome coronavirus, Nipah virus, Chikungunya, Rift Valley fever) and three vaccine platforms to develop vaccines against Disease X, a novel or unanticipated pathogen. As an entity largely supported by public funds, ensuring equitable access to vaccines whose development it supports in low- and middle-income countries is CEPI's primary focus. CEPI developed an initial equitable access policy shortly after its formation, with key stakeholders expressing strong views about its content and prescriptive nature. The CEPI board instructed that it be revisited after a year. This paper describes the process of revising the policy, and how key issues were resolved. CEPI will continue to take an iterative, rather than prescriptive, approach to its policy—one that reflects the needs of multiple stakeholders and ensures it can meet its equitable access goals. © 2020 The Authors",Emerging infectious diseases; Epidemic preparedness; Equitable Access; Vaccine development,Lassa fever virus vaccine; Middle East respiratory syndrome coronavirus vaccine; Nipah virus vaccine; Rift Valley fever virus vaccine; unclassified drug; virus vaccine; Chikungunya virus; Coalition for Epidemic Preparedness Innovations; drug research; epidemic; equipoise; health care access; health care financing; health care policy; human; Lassa virus; low income country; Middle East respiratory syndrome coronavirus; middle income country; Nipah virus; prescription; priority journal; public-private partnership; Review; Rift Valley fever virus; stakeholder engagement,"(2018), https://cepi.net/wp-content/uploads/2019/01/Equitable-Access-Policy.pdf, Coalition for Epidemic Preparedness Innovations. CEPI's Equitable Access Policy, last updated December 20 [accessed August 21 2019]; https://cepi.net/wp-content/uploads/2019/03/Advancing-Equitable-Access_CEPI_29032019.pdf, Coalition for Epidemic Preparedness Innovations. Advancing Equitable Access to epidemic vaccines through CEPI's vaccine and platform development agreements, [accessed 21 August 2019]; https://cepi.net/wp-content/uploads/2019/03/CfP3-TEMPLATE-Funding-Agreement-and-Terms-and-Conditions-.docx, Coalition for Epidemic Preparedness Innovations. Funding agreement and Terms and Conditions, [accessed 21 August 2019]","Lurie, N.; Coalition for Epidemic Preparedness Innovations, 1901 Pennsylvania Ave NW, Suite 1003, United States; email: nicole.lurie@cepi.net",,Elsevier Ltd,0264410X,,VACCD,32005536,English,Vaccine,Review,Final,Open Access,Scopus,2-s2.0-85078413358,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Chen Y.H., Peng J.S.",57215040642;57215070049;,Treatment strategy for gastrointestinal tumor under the outbreak of novel coronavirus pneumonia in China,2020,Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery,23,2,,I,IV,,,10.3760/cma.j.issn.1671-0274.2020.02.001,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079821792&doi=10.3760%2fcma.j.issn.1671-0274.2020.02.001&partnerID=40&md5=7021b3f157e7262c0aa5648f0bdbd19c,"Department of Gastrointestinal Surgery, Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510655, China","Chen, Y.H., Department of Gastrointestinal Surgery, Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510655, China; Peng, J.S.","当前,我国新型冠状病毒肺炎(简称""新冠肺炎"")的疫情形势严峻,全国医护人员都义不容辞地肩负起了抗击疫情的重任。作为胃肠外科医师,我们应积极学习新冠肺炎的相关知识,科学应对,把防疫的意识渗透到临床工作的每个诊疗细节和临床操作中去。对于胃肠肿瘤患者,首先应做好入院前筛查,肺部CT应作为常规检查项目。经过严密筛查的患者入院后术前检查时需加强防护措施,包括医护人员的自我防护;诊疗过的器械或物品应妥善丢弃,或按规范流程进行消毒,严防交叉感染。对于胃肠道良性肿瘤,如无合并明显出血或梗阻,不建议在这个非常时期进行手术治疗,可待疫情高峰期过后择期手术。对于进展期胃肠恶性肿瘤患者,建议经过多学科联合会诊(MDT),如果符合新辅助治疗指征,应优先选择新辅助治疗而推迟手术。胃肠道肿瘤合并梗阻或出血的病例可考虑通过内镜或介入治疗解除梗阻或止血;若肿瘤合并出血保守治疗及内镜治疗无效,可尝试于介入下进行选择性血管栓塞;合并梗阻但没有合并腹膜炎者,肠道支架置入具有较高的解除梗阻成功率,大部分患者可免于急诊手术。对于胃窦肿瘤合并胃潴留、食管胃结合部肿瘤合并食管梗阻的患者,可留置胃管和空肠营养管,进行减压和营养支持以缓解症状,为限期手术创造更好的身体情况。对于确实需要手术、且疑似或确诊新冠肺炎患者,在向医院、疾控中心进行报备的前提下,最好转至定点医院诊治,或于专门隔离病区进行术前准备、专门的通道进行转运以及专门的感染手术室进行手术;麻醉医师在三级预防的基础上注意配戴防护面罩进行气管插管及拔管,以防飞沫喷溅。对于下消化道手术,应更积极行预防性肠造口。术后对手术间进行彻底消毒。对于手术后发热患者,应与新冠肺炎相鉴别,若伴咳嗽、咳痰者,应按疑似新冠肺炎病例的标准进行单间隔离和相关检查。相信通过医患双方的共同努力,取得这场防疫战争的胜利将指日可待!.The outbreak of the novel coronavirus pneumonia (NCP) has become a public health emergency in China. Chinese authorities and health agencies had devoted great efforts to control this disease. As surgeons specialized in the treatment of gastrointestinal tumors, we should always be aware of the prevention for NCP and incorporate this awareness into every detail of clinical practice. For the patients with gastrointestinal tumors, pre-admission screening should be done in order to rule out NCP. Real-time RT-PCR panel and chest CT scan should be conducted for patients with fever (>37.3℃), travel history to Hubei Province within 14 days, or contact history with residents from Wuhan district within 14 days. Prevention measures for both medical staffs and the screen-negative admitted patients should also be enhanced because false negative is possible. Medical instruments should be properly discarded or disinfected according to standardized procedures established by the local center for disease control and prevention (CDC). Surgical operation should be reduced at a minimal level to prevent cross infection in this special period.Surgical intervention for benign tumor should be postponed. For malignant tumor, multidisciplinary therapy (MDT) is recommended and non-surgical anti-tumor therapy should be selected with higher priority. Neoadjuvant therapy is highly recommended for gastrointestinal cancer at advanced stages that meet the indications of NCCN guideline (gastric cancer T stage ≥ 2/rectal cancer T stage ≥ 3/unresectable colon cancer). Gastric or esophagogastricjunction (EGJ) malignant tumor with obstruction can be managed with gastric tube decompression or stent placement to relieve the symptoms. Transnasal enteral feeding tube intubation/percutaneous endoscopic gastrostomy could be adopted to ensure enteral nutrition supply. For colorectal malignancy with simple intestinal obstruction, stent placement can achieve a high success rate, which not only helps avoid emergency surgery, but also creates a better condition for subsequent surgery. Transcatheter arterial embolization for hemostasis is an alternative choice for gastrointestinal tumor with bleeding. However, emergency operation still must be performed for patients with acute uncontrolled bleeding, obstruction or after other alternative treatment measures fail. All cases with suspicious or confirmed with NCP must be reported to the local CDC department. All invasive intervention must be performed in a designated isolation area. Tertiary prevention measure must be adopted for all anesthetists with additional face mask or medical goggle protection to prevent respiratory droplet transmission. Preventive enterostomy is preferable in lower digestive tract surgery. Thoroughly disinfecting the operating room after surgery is necessary. Fever after surgery must be carefully differentiated whether it's caused by post-surgery abdominal infection/inflammation or NCP. Single-room isolation and related examinations should be performed according to the standard procedures. We believe that with the unprecedentedly joint efforts of doctors and patients, we will eventually win this war against NCP.","Gastrointestinal tumor, treatment strategy; Multidisciplinary therapy; Novel coronavirus pneumonia (NCP)","China; Coronavirinae; Coronavirus infection; epidemic; human; mass screening; rectum tumor; virology; virus pneumonia; China; Coronavirus; Coronavirus Infections; Disease Outbreaks; Humans; Mass Screening; Pneumonia, Viral; Rectal Neoplasms",,,,NLM (Medline),16710274,,,32074786,Chinese,Zhonghua Wei Chang Wai Ke Za Zhi,Article,Final,,Scopus,2-s2.0-85079821792,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Aavitsland P.,57215446830;,The coronavirus epidemic will reach Norway [Koronavirusepidemien vil ramme Norge],2020,"Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke",140,3,,,,,,10.4045/tidsskr.20.0077,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080835479&doi=10.4045%2ftidsskr.20.0077&partnerID=40&md5=f61a1fcda5bac33714291351eb5d3a30,,"Aavitsland, P.",[No abstract available],,,,,,NLM (Medline),8077096,,,32105045,English; Norwegian,Tidsskr. Nor. Laegeforen.,Article,Final,Open Access,Scopus,2-s2.0-85080835479,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Phelan A.L., Katz R., Gostin L.O.",56242733500;7401788556;7102748505;,"The Novel Coronavirus Originating in Wuhan, China: Challenges for Global Health Governance",2020,JAMA - Journal of the American Medical Association,323,8,,709,710,,16,10.1001/jama.2020.1097,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078894398&doi=10.1001%2fjama.2020.1097&partnerID=40&md5=a9cb09b4f68d83476697551c87ba87b8,"Center for Global Health Science and Security, Georgetown University, Washington, DC, United States; O'Neill Institute for National and Global Health Law, Georgetown University Law Center, 600 New Jersey Ave NW, Washington, DC 20001, United States","Phelan, A.L., Center for Global Health Science and Security, Georgetown University, Washington, DC, United States, O'Neill Institute for National and Global Health Law, Georgetown University Law Center, 600 New Jersey Ave NW, Washington, DC 20001, United States; Katz, R., Center for Global Health Science and Security, Georgetown University, Washington, DC, United States; Gostin, L.O., O'Neill Institute for National and Global Health Law, Georgetown University Law Center, 600 New Jersey Ave NW, Washington, DC 20001, United States",[No abstract available],,2019 novel coronavirus; awareness; China; Coronavirinae; disease control; disease severity; disease transmission; epidemic; epidemiologist; evidence based medicine; global health; health care delivery; health hazard; human; isolation; nonhuman; Note; prediction; priority journal; public health; World Health Organization,"(2019), https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200128-sitrep-8-ncov-cleared.pdf?sfvrsn=8b671ce5_2, Novel coronavirus (-nCoV) situation report-8.. January 28, 2020; https://www.cdc.gov/coronavirus/2019-ncov/about/symptoms.html, 2019 Novel coronavirus, Wuhan, China: Symptoms.. Published January 26, 2020. Accessed January 27, 2020; Shih, G., Lynch, D.J., Denyer, S., Shammas, B., https://www.washingtonpost.com/world/asia_pacific/coronavirus-china-latest-updates/2020/01/26/4603266c-3fa8-11ea-afe2-090eb37b60b1_story.html, Chinese coronavirus infections, death toll soar as fifth case is confirmed in U.S.. Published January 26, 2020. Accessed January 27, 2020; https://www.hongkongfp.com/2020/01/25/breaking-hong-kong-declares-wuhan-virus-outbreak-emergency-highest-warning-tier, Hong Kong Free Press.. January 25, 2020; Markel, H., Lipman, H.B., Navarro, J.A., Nonpharmaceutical interventions implemented by US cities during the 1918-1919 influenza pandemic (2007) JAMA, 298 (6), pp. 644-654. , 17684187; Shih, G., Denyer, S., Wuhan Mayor Says 5 Million People Left City in Recent Days, , https://www.washingtonpost.com/world/coronavirus-china-latest-updates/2020/01/27/3634db9a-40a7-11ea-aa6a-083d01b3ed18_story.html, Washington Post.. January 27, 2020; (2008), https://www.who.int/ihr/publications/9789241596664/en/, International Health Regulations. 2nd ed.. Published. Accessed January 27, 2020; Gostin, L.O., Debartolo, M.C., Katz, R., The global health law trilogy: Towards a safer, healthier, and fairer world (2017) Lancet, 390, pp. 1918-1926. , 28521917 10105","Gostin, L.O.; O'Neill Institute for National and Global Health Law, Georgetown University Law Center, 600 New Jersey Ave NW, United States; email: gostin@law.georgetown.edu",,American Medical Association,987484,,JAMAA,31999307,English,JAMA,Note,Final,Open Access,Scopus,2-s2.0-85078894398,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Paules C.I., Marston H.D., Fauci A.S.",57193527875;55883400800;35392031000;,Coronavirus Infections-More Than Just the Common Cold,2020,JAMA - Journal of the American Medical Association,323,8,,707,708,,37,10.1001/jama.2020.0757,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078468946&doi=10.1001%2fjama.2020.0757&partnerID=40&md5=2094cb8997dd657e94c932c83af94d6a,"Penn State University College of Medicine, Milton S. Hershey Medical Center, Hershey, PA, United States; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Maryland Laboratory of Immunoregulation, 31 Center Dr, MSC 2520, Bldg 31, Room 7A-03, Bethesda, MD 20892-2520, United States","Paules, C.I., Penn State University College of Medicine, Milton S. Hershey Medical Center, Hershey, PA, United States; Marston, H.D., National Institute of Allergy and Infectious Diseases, National Institutes of Health, Maryland Laboratory of Immunoregulation, 31 Center Dr, MSC 2520, Bldg 31, Room 7A-03, Bethesda, MD 20892-2520, United States; Fauci, A.S., National Institute of Allergy and Infectious Diseases, National Institutes of Health, Maryland Laboratory of Immunoregulation, 31 Center Dr, MSC 2520, Bldg 31, Room 7A-03, Bethesda, MD 20892-2520, United States",[No abstract available],,angiotensin converting enzyme 2; beta interferon; cell receptor; coronavirus spike glycoprotein; dipeptidyl peptidase IV; glycoprotein; lopinavir plus ritonavir; messenger RNA; remdesivir; 2019 novel coronavirus; acute kidney failure; aerosol; airborne virus; artificial ventilation; biological model; case fatality rate; China; Chinese; common cold; comorbidity; Coronavirinae; Coronavirus infection; coughing; disease severity; disease transmission; dyspnea; environmental exposure; epidemic; fever; gastrointestinal symptom; gastrointestinal tract; gene mutation; gene sequence; general practitioner; genetic recombination; genetic variability; health care cost; health care system; Hong Kong; hospital infection; hospitalization; host interaction; host range; human; Human coronavirus 229E; Human coronavirus HKU1; Human coronavirus NL63; Human coronavirus OC43; lower respiratory tract; Middle East respiratory syndrome; Middle East respiratory syndrome coronavirus; morbidity; mortality; Note; pandemic; patient isolation; phase 1 clinical trial (topic); priority journal; public health service; raccoon dog; respiratory failure; respiratory tract intubation; SARS-related coronavirus; Saudi; sea food; severe acute respiratory syndrome; social marketing; therapy effect; travel; United States; upper respiratory tract infection; virology; virus cell interaction; virus envelope; virus pneumonia; virus shedding; virus virulence,"De Wilde, A.H., Snijder, E.J., Kikkert, M., Van Hemert, M.J., Host factors in coronavirus replication (2018) Curr Top Microbiol Immunol, 419, pp. 1-42. , doi: 28643204; De Wit, E., Van Doremalen, N., Falzarano, D., Munster, V.J., SARS and MERS: Recent insights into emerging coronaviruses (2016) Nat Rev Microbiol, 14 (8), pp. 523-534. , doi: 27344959; Song, Z., Xu, Y., Bao, L., From SARS to MERS, thrusting coronaviruses into the spotlight (2019) Viruses, 11 (1), p. 11. , doi: 30646565; Yu, I.T., Li, Y., Wong, T.W., Evidence of airborne transmission of the severe acute respiratory syndrome virus (2004) N Engl J Med, 350 (17), pp. 1731-1739. , doi: 15102999; Sheahan, T.P., Sims, A.C., Leist, S.R., Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV (2020) Nat Commun, 11 (1), p. 222. , doi: 31924756; Graham, B.S., Mascola, J.R., Fauci, A.S., Novel vaccine technologies: Essential components of an adequate response to emerging viral diseases (2018) JAMA, 319 (14), pp. 1431-1432. , http://jamanetwork.com/article.aspx?doi=10.1001/jama.2018.0345","Fauci, A.S.; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Maryland Laboratory of Immunoregulation, 31 Center Dr, MSC 2520, Bldg 31, Room 7A-03, United States; email: afauci@niaid.nih.gov",,American Medical Association,987484,,JAMAA,31971553,English,JAMA,Note,Final,Open Access,Scopus,2-s2.0-85078468946,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Ren S.-Y., Gao R.-D., Chen Y.-L.",39762651500;57215432461;57215423337;,Fear can be more harmful than the severe acute respiratory syndrome coronavirus 2 in controlling the corona virus disease 2019 epidemic,2020,World Journal of Clinical Cases,8,4,,652,657,,,10.12998/wjcc.v8.i4.652,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080906252&doi=10.12998%2fwjcc.v8.i4.652&partnerID=40&md5=24d41575dc463b880041380e60eb1958,"Vascular Surgery, Department of General Surgery, Aviation, General Hospital, China Medical University, Beijing, 100012, China; College of Robotics, Beijing Union University, Beijing, 100101, China","Ren, S.-Y., Vascular Surgery, Department of General Surgery, Aviation, General Hospital, China Medical University, Beijing, 100012, China; Gao, R.-D., Vascular Surgery, Department of General Surgery, Aviation, General Hospital, China Medical University, Beijing, 100012, China; Chen, Y.-L., College of Robotics, Beijing Union University, Beijing, 100101, China","The current corona virus disease 2019 outbreak caused by severe acute respiratory syndrome coronavirus 2 started in Wuhan, China in December 2019 and has put the world on alert. To safeguard Chinese citizens and to strengthen global health security, China has made great efforts to control the epidemic. Many in the global community have joined China to limit the epidemic. However, discrimination and prejudice driven by fear or misinformation have been flowing globally, superseding evidence and jeopardizing the anti-severe acute respiratory syndrome coronavirus 2 efforts. We analyze this phenomenon and its underlying causes and suggest practical solutions. © Baishideng Publishing Group Co.",Coronavirus; Coronavirus disease 2019; Discrimination; Fear; Outbreak; Prejudice; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2,Article; China; corona virus disease 2019; epidemic; fear; geographic distribution; government; hand washing; human; mental health; prejudice; risk factor; SARS coronavirus; scientific literature; severe acute respiratory syndrome; stigma; virus infection; World Health Organization,"Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Zhang, L., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study (2020) Lancet, 395, pp. 507-513. , [PMID: 32007143]; Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Wang, B., Peng, Z., Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China (2020) JAMA, , [PMID: 32031570]; Lu, C.W., Liu, X.F., Jia, Z.F., 2019-nCoV transmission through the ocular surface must not be ignored (2020) Lancet, , [PMID: 32035510]; Lu, H., Drug treatment options for the 2019-new coronavirus (2019-nCoV) (2020) Biosci Trends, , [PMID: 31996494]; Lu, H., Stratton, C.W., Tang, Y.W., Outbreak of pneumonia of unknown etiology in Wuhan, China: The mystery and the miracle (2020) J Med Virol, , [PMID: 31950516]; Wang, W., Tang, J., Wei, F., Updated understanding of the outbreak of 2019 novel coronavirus (2019-nCoV) in Wuhan, China (2020) J Med Virol, , [PMID: 31994742]; Wang, Z., Chen, X., Lu, Y., Chen, F., Zhang, W., Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined Chinese and Western medicine treatment (2020) Biosci Trends, , [PMID: 32037389]; Wilson, M.E., What goes on board aircraft? Passengers include Aedes, Anopheles, 2019-nCoV, dengue, Salmonella, Zika, et al (2020) Travel Med Infect Dis, p. 101572. , [PMID: 32035269]; Wilson, M.E., Chen, L.H., Travelers Give Wings to Novel Coronavirus (2019-nCoV) (2020) J Travel Med, , [PMID: 32010938]; (2020) Pneumonia, , https://www.who.int/csr/don/05-january-2020-pneumonia-of-unkown-cause-china/en/, of unknown cause-China; Holshue, M.L., DeBolt, C., Lindquist, S., Lofy, K.H., Wiesman, J., Bruce, H., Spitters, C., Pillai, S.K., Washington State 2019-nCoV Case Investigation Team. First Case of 2019 Novel Coronavirus in the United States (2020) N Engl J Med, , [PMID: 32004427]; Giovanetti, M., Benvenuto, D., Angeletti, S., Ciccozzi, M., The first two cases of 2019-nCoV in Italy: Where they come from (2020) J Med Virol, , [PMID: 32022275]; Note from the editors: World Health Organization declares novel coronavirus (2019-nCoV) sixth public health emergency of international concern (2020) Euro Surveill, p. 25. , [PMID: 32019636]; Bassetti, M., Vena, A., Giacobbe, D.R., The novel Chinese coronavirus (2019-nCoV) infections: Challenges for fighting the storm (2020) Eur J Clin Invest, p. e13209. , [PMID: 32003000]; Battegay, M., Kuehl, R., Tschudin-Sutter, S., Hirsch, H.H., Widmer, A.F., Neher, R.A., 2019-novel Coronavirus (2019-nCoV): Estimating the case fatality rate-a word of caution (2020) Swiss Med Wkly, 150, p. w20203. , [PMID: 32031234]; Benvenuto, D., Giovanetti, M., Ciccozzi, A., Spoto, S., Angeletti, S., Ciccozzi, M., The 2019-new coronavirus epidemic: Evidence for virus evolution (2020) J Med Virol, , [PMID: 31994738]; Biscayart, C., Angeleri, P., Lloveras, S., Chaves, T.D.S.S., Schlagenhauf, P., Rodríguez-Morales, A.J., The next big threat to global health? 2019 novel coronavirus (2019-nCoV): What advice can we give to travellers?-Interim recommendations January 2020, from the Latin-American society for Travel Medicine (SLAMVI) (2020) Travel Med Infect Dis, p. 101567. , [PMID: 32006657]; Carlos, W.G., Dela Cruz, C.S., Cao, B., Pasnick, S., Jamil, S., Novel Wuhan (2019-nCoV) Coronavirus (2020) Am J Respir Crit Care Med, 201, pp. P7-P8. , [PMID: 32004066]; Shigemura, J., Ursano, R.J., Morganstein, J.C., Kurosawa, M., Benedek, D.M., Public responses to the novel 2019 coronavirus (2019-nCoV) in Japan: Mental health consequences and target populations (2020) Psychiatry Clin Neurosci, , [PMID: 32034840]; (2020) Epidemic report on time, , https://voice.baidu.com/act/newpneumonia/newpneumonia/?from=osari_aladin_top1.Feb.15, (Feb 15,); Wang, F.S., Zhang, C., What to do next to control the 2019-nCoV epidemic (2020) Lancet, 395, pp. 391-393. , [PMID: 32035533]; State Council 's Joint Prevention and Control Mechanism: Seven Major Measures Provide Strong Protection to Frontline Medical Staff, , http://www.gov.cn/xinwen/2020-02/14/con-tent_5478871.htm; WHO Director-General's remarks at the media briefing on COVID-2019 outbreak on 14 February 2020, , https://www.who.int/dg/speeches/detail/who-director-general-s-remarks-at-the-media-briefing-on-covid-2019-outbreak-on-14-february-2020; WHO Director-General's remarks at the media briefing on COVID-2019 outbreak, , http://terrance.who.int/mediacentre/videos/coronavirus/WHO-PROD_Coronavirus_Press_Conference:Tedros_06FEB2020%20ch.mp4.14-february-2020; Discrimination against Chinese a virus: China Daily editorial, , http://ex.chinadaily.com.cn/exchange/partners/45/rss/channel/www/columns/419cf7/stories/WS5e39581aa310128217274d8d.html; Ai, H., Bo, L., WHO holds to line against travel bans (2020) China Daily, , http://global.chinadaily.com.cn/a/202002/05/WS5e3a1f44a310128217274fd8.html, 5 Feb. Cited 17 February 2020; Xi Jinping meets with visiting World Health Organization (WHO) Director-General Tedros Adhanom Ghebreyesus, , http://hou-ston.china-consulate.org/eng/nv/t1737205.htm; Epidemic report on time, , https://voice.baidu.com/act/newpneumonia/newpneumonia; Wang, W., History will note China's strength, West's arrogance (2020) Global Times, , http://www.globaltimes.cn/content/1179067.shtml, 10 Feb. Cited 17 February 2020; Be united, not stigmatized! Multinational leaders oppose discrimination against Chinese: Benighted and illogical!, , http://www.yidianzixun.com/article/0OZwzKT7; Rong, X., Coronavirus a common foe the global village must fight together (2020) Global Times, , https://www.globaltimes.cn/content/1178729.shtml, 6 Feb, Cited 17 February 2020; Chang, J., Who is 'the real sick man'? China or biased author? (2020) China Daily, , http://www.chinadaily.com.cn/a/202002/07/WS5e3cab20a310128217275a06.html, 7 Feb, Cited 17 February 2020; Who gave you the power to prohibit medical staff from returning home?, , https://baijiahao.baidu.com/s?id=1657793996926292623wfr=spiderfor=pcisFailFlag=1; Responses to outbreak widely praised, , http://ex.chinadaily.com.cn/exchange/partners/45/rss/channel/www/columns/f8gszh/stories/WS5e3b7785a310128217275603.html; Gorbalenya, A.E., Baker, S.C., Baric, R.S., de Groot, R.J., Drosten, C., Gulyaeva, A.A., Haagmans, B.L., Ziebuhr, J., (2020) Severe acute respiratory syndrome-related coronavirus: The species and its viruses-a statement of the Coronavirus Study Group, , Available from: bioRxiv: 937862. Preprint; WHO guidelines for 2019-nCoV, , https://www.who.int/emergencies/diseases/novel-coronavirus-2019; Notification of novel coronavirus pneumonia temporarily named by the national health and Health Commission, , http://www.gov.cn/zhengce/zhengceku/2020-02/08/content_5476248.htm; Ceraolo, C., Giorgi, F.M., Genomic variance of the 2019-nCoV coronavirus (2020) J Med Virol, , [PMID: 32027036]; Coronavirus disease gets an official name: COVID-19, , https://www.cnet.com/news/coronavirus-disease-gets-an-official-name-covid-19/; In order to prevent the spread of epidemic situation, some villages in Henan Province have to arrange specially assigned persons to be on duty at the road and intersection, , http://m.sohu.com/a/368997508_114988; Andhra man wrongly thinks he has coronavirus, kills self to protect village, , https://www.indiatoday.in/india/story/andhra-pradesh-chittoor-man-wrongly-believes-coronavirus-kills-self-1645578-2020-02-12; Novel coronavirus is a genetic weapon and a conspiracy of the United States The wise will not listen to rumors, , https://c.m.163.com/news/a/F4H53T8H0517DRJS.html?spss=news-appspsw=1; The new coronavirus triggered racial discrimination, overseas Chinese protesting:"" I am Chinese, not a virus"", , http://m.sohu.com/a/370527634_299706","Ren, S.-Y.; Vascular Surgery, Department of General Surgery, Aviation, General Hospital, China Medical UniversityChina; email: rens66@126.com",,Baishideng Publishing Group Co,23078960,,,,English,World J. Clin. Cases,Article,Final,Open Access,Scopus,2-s2.0-85080906252,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, COVID-19 National Incident Room Surveillance Team,,"COVID-19, Australia: Epidemiology Report 4 (Reporting week ending 19:00 AEDT 22 February 2020)",2020,Communicable diseases intelligence (2018),44,,,,,,,10.33321/cdi.2020.44.17,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082092864&doi=10.33321%2fcdi.2020.44.17&partnerID=40&md5=d46080ef856ae5b7a6008f14fa0985f3,,COVID-19 National Incident Room Surveillance Team,"This is the fourth epidemiological report for coronavirus disease 2019 (COVID-19), reported in Australia as at 19:00 Australian Eastern Daylight Time [AEDT] 22 February 2020. It includes data on COVID-19 cases diagnosed in Australia, the international situation and a review of current evidence. © Commonwealth of Australia CC BY-NC-ND.",2019-nCoV; acute respiratory disease; Australia; case definition; coronavirus disease 2019; COVID-19; epidemiology; novel coronavirus; SARS-CoV-2,"COVID-19; severe acute respiratory syndrome coronavirus 2; Australia; Betacoronavirus; Coronavirus infection; human; virus pneumonia; Australia; Betacoronavirus; Coronavirus Infections; Humans; Pneumonia, Viral",,,,NLM (Medline),22096051,,,32098616,English,Commun Dis Intell (2018),Article,Final,Open Access,Scopus,2-s2.0-85082092864,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Giwa A., Desai A.",57216003529;57215380607;,Novel coronavirus COVID-19: an overview for emergency clinicians,2020,Emergency medicine practice,22,2,,1,21,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080830097&partnerID=40&md5=f750432d0edd69b230d19e648c8bc487,"Associate Professor of Emergency Medicine, Icahn School of Medicine at Mount Sinai, NY, NY; Icahn School of Medicine at Mount Sinai, NY, NY","Giwa, A., Associate Professor of Emergency Medicine, Icahn School of Medicine at Mount Sinai, NY, NY; Desai, A., Icahn School of Medicine at Mount Sinai, NY, NY","Prior to the global outbreak of SARS-CoV in 2003, HCoV-229E and HCoV-OC43 were the only coronaviruses known to infect humans. Following the SARS outbreak, 5 additional coronaviruses have been discovered in humans, most recently the novel coronavirus COVID-19, believed to have originated in Wuhan, Hubei Province, China. SARS-CoV and MERSCoV are particularly pathogenic in humans and are associated with high mortality. In this review, the epidemiology, pathophysiology, and management of the recently discovered COVID-19 are reviewed, with a focus on best practices and the public health implications.",,"COVID-19; Coronavirus infection; emergency health service; human; pathogenicity; public health; SARS coronavirus; virus pneumonia; Coronavirus Infections; Emergency Medical Services; Humans; Pneumonia, Viral; Public Health; SARS Virus",,,,NLM (Medline),15593908,,,32105049,English,Emerg Med Pract,Review,Final,,Scopus,2-s2.0-85080830097,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Goraichuk I.V., Davis J.F., Kulkarni A.B., Afonso C.L., Suarez D.L.",57190967096;55740890000;36696541000;57203211804;57207843256;,"A 25-year-old sample contributes the complete genome sequence of avian coronavirus vaccine strain ARKDPI, reisolated from commercial broilers in the United States",2020,Microbiology Resource Announcements,9,9, e00067-20,,,,,10.1128/MRA.00067-20,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082505306&doi=10.1128%2fMRA.00067-20&partnerID=40&md5=cf481b9b2d68f7cde183d844d74a6117,"Exotic and Emerging Avian Viral Disease Research Unit, Southeast Poultry Research Laboratory, U.S. National Poultry Research Center, ARS, USDA, Athens, GA, United States; Georgia Poultry Laboratory Network, Gainesville, GA, United States","Goraichuk, I.V., Exotic and Emerging Avian Viral Disease Research Unit, Southeast Poultry Research Laboratory, U.S. National Poultry Research Center, ARS, USDA, Athens, GA, United States; Davis, J.F., Georgia Poultry Laboratory Network, Gainesville, GA, United States; Kulkarni, A.B., Georgia Poultry Laboratory Network, Gainesville, GA, United States; Afonso, C.L., Exotic and Emerging Avian Viral Disease Research Unit, Southeast Poultry Research Laboratory, U.S. National Poultry Research Center, ARS, USDA, Athens, GA, United States; Suarez, D.L., Exotic and Emerging Avian Viral Disease Research Unit, Southeast Poultry Research Laboratory, U.S. National Poultry Research Center, ARS, USDA, Athens, GA, United States","Here, we report the complete genome sequence of Avian coronavirus strain ArkDPI of the GI-9 lineage, isolated from broiler chickens in North Georgia in 1994. This is the complete genome sequence of this vaccine strain, reisolated from broilers in the United States. © 2020 American Society for Microbiology. All rights reserved.",,,"Jackwood, M.W., de Wit, S., Infectious bronchitis (2013) Diseases of Poultry, pp. 139-159. , Swayne DE, Glisson JR, McDougald LR, Nolan LK, Suarez DL, Nair VL ed, 13th ed. John Wiley and Sons, Inc., Oxford, United Kingdom; Cavanagh, D., Coronavirus avian infectious bronchitis virus (2007) Vet Res, 38, pp. 281-297. , https://doi.org/10.1051/vetres:2006055; Naqi, S., Gay, K., Patalla, P., Mondal, S., Liu, R., Establishment of persistent avian infectious bronchitis virus infection in antibody-free and antibody-positive chickens (2003) Avian Dis, 47, pp. 594-601. , https://doi.org/10.1637/6087; King, A.M.Q., Lefkowitz, E.J., Mushegian, A.R., Adams, M.J., Dutilh, B.E., Gorbalenya, A.E., Harrach, B., Davison, A.J., Changes to taxonomy and the International Code of Virus Classification and Nomenclature ratified by the International Committee on Taxonomy of Viruses (2018) (2018) Arch Virol, 163, pp. 2601-2631. , https://doi.org/10.1007/s00705-018-3847-1; Jackwood, M.W., Hilt, D.A., Lee, C.W., Kwon, H.M., Callison, S.A., Moore, K.M., Moscoso, H., Thayer, S., Data from 11 years of molecular typing infectious bronchitis virus field isolates (2005) Avian Dis, 49, pp. 614-618. , https://doi.org/10.1637/7389-052905R.1; Leyson, C.M., Hilt, D.A., Jordan, B.J., Jackwood, M.W., Minimum infectious dose determination of the Arkansas Delmarva Poultry Industry infectious bronchitis virus vaccine delivered by hatchery spray cabinet (2017) Avian Dis, 61, pp. 123-127. , https://doi.org/10.1637/11474-072216-ResNote; Nix, W.A., Troeber, D.S., Kingham, B.F., Keeler, C.L., Jr., Gelb, J., Jr., Emergence of subtype strains of the Arkansas serotype of infectious bronchitis virus in Delmarva broiler chickens (2000) Avian Dis, 44, pp. 568-581. , https://doi.org/10.2307/1593096; Jackwood, M.W., Hilt, D.A., McCall, A.W., Polizzi, C.N., McKinley, E.T., Williams, S.M., Infectious bronchitis virus field vaccination coverage and persistence of Arkansas-type viruses in commercial broilers (2009) Avian Dis, 53, pp. 175-183. , https://doi.org/10.1637/8465-090308-Reg.1; Jackwood, M.W., Lee, D.H., Different evolutionary trajectories of vaccine-controlled and non-controlled avian infectious bronchitis viruses in commercial poultry (2017) PLoS One, 12. , https://doi.org/10.1371/journal.pone.0176709; Leyson, C., França, M., Jackwood, M., Jordan, B., Polymorphisms in the S1 spike glycoprotein of Arkansas-type infectious bronchitis virus (IBV) show differential binding to host tissues and altered antigenicity (2016) Virology, 498, pp. 218-225. , https://doi.org/10.1016/j.virol.2016.08.030; McKinley, E.T., Hilt, D.A., Jackwood, M.W., Avian coronavirus infectious bronchitis attenuated live vaccines undergo selection of subpopulations and mutations following vaccination (2008) Vaccine, 26, pp. 1274-1284. , https://doi.org/10.1016/j.vaccine.2008.01.006; Toro, H., van Santen, V.L., Jackwood, M.W., Genetic diversity and selection regulates evolution of infectious bronchitis virus (2012) Avian Dis, 56, pp. 449-455. , https://doi.org/10.1637/10072-020212-Review.1; van Santen, V.L., Toro, H., Rapid selection in chickens of subpopulations within ArkDPI-derived infectious bronchitis virus vaccines (2008) Avian Pathol, 37, pp. 293-306. , https://doi.org/10.1080/03079450802043783; Davis, J.F., Castro, A.E., de la Torre, J.C., Barnes, H.J., Doman, J.T., Metz, M., Lu, H., Teng, M.N., Experimental reproduction of severe hypoglycemia and spiking mortality syndrome using field-derived and embryo-passaged preparations (1996) Avian Dis, 40, pp. 158-172. , https://doi.org/10.2307/1592385; Chrzastek, K., Lee, D.H., Smith, D., Sharma, P., Suarez, D.L., Pantin-Jackwood, M., Kapczynski, D.R., Use of sequence-independent, single-primer-amplification (SISPA) for rapid detection, identification, and characterization of avian RNA viruses (2017) Virology, 509, pp. 159-166. , https://doi.org/10.1016/j.virol.2017.06.019; Afgan, E., Baker, D., van den Beek, M., Blankenberg, D., Bouvier, D., Čech, M., Chilton, J., Goecks, J., The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2016 update (2016) Nucleic Acids Res, 44, pp. W3-W10. , https://doi.org/10.1093/nar/gkw343; Goraichuk, I.V., Kulkarni, A.B., Williams-Coplin, D., Suarez, D.L., Afonso, C.L., First complete genome sequence of currently circulating infectious bronchitis virus strain DMV/1639 of the GI-17 lineage (2019) Microbiol Resour Announc, 8, pp. e00840-e00919. , https://doi.org/10.1128/MRA.00840-19; Dimitrov, K.M., Sharma, P., Volkening, J.D., Goraichuk, I.V., Wajid, A., Rehmani, S.F., Basharat, A., Afonso, C.L., A robust and cost-effective approach to sequence and analyze complete genomes of small RNA viruses (2017) Virol J, 14, p. 72. , https://doi.org/10.1186/s12985-017-0741-5; Andrews, S., (2020) FastQC: A Quality Control Tool for High Throughput Sequence Data, , http://www.bioinformatics.babraham.ac.uk/projects/fastqc/; Martin, M., Cutadapt removes adapter sequences from high-throughput sequencing reads (2011) EMBnet J, 17, pp. 10-12. , https://doi.org/10.14806/ej.17.1.200; Zhang, J., Kobert, K., Flouri, T., Stamatakis, A., PeAR: A fast and accurate Illumina Paired-End reAd mergeR (2014) Bioinformatics, 30, pp. 614-620. , https://doi.org/10.1093/bioinformatics/btt593; Crusoe, M.R., Alameldin, H.F., Awad, S., Boucher, E., Caldwell, A., Cartwright, R., Charbonneau, A., Standage, D., The Khmer software package: Enabling efficient nucleotide sequence analysis (2015) F1000Res, 4, p. 900. , https://doi.org/10.12688/f1000research.6924.1; Chevreux, B., Wetter, T., Suhai, S., Genome sequence assembly using trace signals and additional sequence information (1999) Computer Science and Biology: Proceedings of the German Conference on Bioinformatics (GCB’99), pp. 45-56. , Wingender E ed, GBF-Braunschweig, Department of Bioinformatics, Braunschweig, Germany; Li, H., Durbin, R., Fast and accurate short read alignment with Burrows-Wheeler transform (2009) Bioinformatics, 25, pp. 1754-1760. , https://doi.org/10.1093/bioinformatics/btp324; Ammayappan, A., Upadhyay, C., Gelb, J., Jr., Vakharia, V.N., Complete genomic sequence analysis of infectious bronchitis virus Ark DPI strain and its evolution by recombination (2008) Virol J, 5, p. 157. , https://doi.org/10.1186/1743-422X-5-157; Ammayappan, A., Upadhyay, C., Gelb, J., Jr., Vakharia, V.N., Identification of sequence changes responsible for the attenuation of avian infectious bronchitis virus strain Arkansas DPI (2009) Arch Virol, 154, pp. 495-499. , https://doi.org/10.1007/s00705-009-0325-9; Valastro, V., Holmes, E.C., Britton, P., Fusaro, A., Jackwood, M.W., Cattoli, G., Monne, I., S1 gene-based phylogeny of infectious bronchitis virus: An attempt to harmonize virus classification (2016) Infect Genet Evol, 39, pp. 349-364. , https://doi.org/10.1016/j.meegid.2016.02.015; Ndegwa, E.N., Toro, H., van Santen, V.L., Comparison of vaccine subpopulation selection, viral loads, vaccine virus persistence in trachea and cloaca, and mucosal antibody responses after vaccination with two different Arkansas Delmarva Poultry Industry-derived infectious bronchitis virus vaccines (2014) Avian Dis, 58, pp. 102-110. , https://doi.org/10.1637/10609-070613-Reg.1","Suarez, D.L.; Exotic and Emerging Avian Viral Disease Research Unit, Southeast Poultry Research Laboratory, U.S. National Poultry Research Center, ARS, USDAUnited States; email: david.suarez@usda.gov",,American Society for Microbiology,2576098X,,,,English,Micro. Res. Ann,Article,Final,Open Access,Scopus,2-s2.0-85082505306,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Goraichuk I.V., Davis J.F., Kulkarni A.B., Afonso C.L., Suarez D.L.",57190967096;55740890000;36696541000;57203211804;57207843256;,Complete genome sequence of avian coronavirus strain GA08 (Gi-27 lineage),2020,Microbiology Resource Announcements,9,9, e00068-20,,,,,10.1128/MRA.00068-20,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082472484&doi=10.1128%2fMRA.00068-20&partnerID=40&md5=2891554b0900bef6ab21c1499f97d8d1,"Exotic and Emerging Avian Viral Disease Research Unit, Southeast Poultry Research Laboratory, U.S. National Poultry Research Center, ARS, USDA, Athens, GA, United States; Georgia Poultry Laboratory Network, Gainesville, GA, United States","Goraichuk, I.V., Exotic and Emerging Avian Viral Disease Research Unit, Southeast Poultry Research Laboratory, U.S. National Poultry Research Center, ARS, USDA, Athens, GA, United States; Davis, J.F., Georgia Poultry Laboratory Network, Gainesville, GA, United States; Kulkarni, A.B., Georgia Poultry Laboratory Network, Gainesville, GA, United States; Afonso, C.L., Exotic and Emerging Avian Viral Disease Research Unit, Southeast Poultry Research Laboratory, U.S. National Poultry Research Center, ARS, USDA, Athens, GA, United States; Suarez, D.L., Exotic and Emerging Avian Viral Disease Research Unit, Southeast Poultry Research Laboratory, U.S. National Poultry Research Center, ARS, USDA, Athens, GA, United States","Avian coronavirus, also known as infectious bronchitis virus, is a highly contagious respiratory pathogen of chickens that is responsible for major economic losses to the poultry industry around the globe. Here, we report the complete genome sequence of strain GA08 of the GI-27 lineage, isolated from a fecal sample from a broiler chicken collected in Georgia in 2015. © 2020 American Society for Microbiology. All rights reserved.",,article; Avian coronavirus; broiler; feces; human tissue; nonhuman,"Jackwood, M.W., de Wit, J.J., Infectious bronchitis (2013) Diseases of Poultry, pp. 139-159. , Swayne DEGJ, McDougald LR, Nolan LK, Suarez DL, Nair ed, 13th ed. John Wiley and Sons, Inc., Hoboken, NJ; Cavanagh, D., Coronavirus avian infectious bronchitis virus (2007) Vet Res, 38, pp. 281-297. , https://doi.org/10.1051/vetres:2006055; King, A.M.Q., Lefkowitz, E.J., Mushegian, A.R., Adams, M.J., Dutilh, B.E., Gorbalenya, A.E., Harrach, B., Davison, A.J., Changes to taxonomy and the International Code of Virus Classification and Nomenclature ratified by the International Committee on Taxonomy of Viruses (2018) (2018) Arch Virol, 163, pp. 2601-2631. , https://doi.org/10.1007/s00705-018-3847-1; Roh, H.J., Hilt, D.A., Jackwood, M.W., Simultaneous detection of five major serotypes of Avian coronavirus by a multiplex microspherebased assay (2013) J Vet Diagn Invest, 25, pp. 458-466. , https://doi.org/10.1177/1040638713493906; Liu, S., Chen, J., Han, Z., Zhang, Q., Shao, Y., Kong, X., Tong, G., Infectious bronchitis virus: S1 gene characteristics of vaccines used in China and efficacy of vaccination against heterologous strains from China (2006) Avian Pathol, 35, pp. 394-399. , https://doi.org/10.1080/03079450600920984; Jackwood, M.W., Hilt, D.A., Sellers, H.S., Williams, S.M., Lasher, H.N., Rapid heat-treatment attenuation of infectious bronchitis virus (2010) Avian Pathol, 39, pp. 227-233. , https://doi.org/10.1080/03079451003801516; Kulkarni, A.B., Resurreccion, R.S., Genotyping of newly isolated infectious bronchitis virus isolates from northeastern Georgia (2010) Avian Dis, 54, pp. 1144-1151. , https://doi.org/10.1637/9358-040510-Reg.1; Valastro, V., Holmes, E.C., Britton, P., Fusaro, A., Jackwood, M.W., Cattoli, G., Monne, I., S1 gene-based phylogeny of infectious bronchitis virus: An attempt to harmonize virus classification (2016) Infect Genet Evol, 39, pp. 349-364. , https://doi.org/10.1016/j.meegid.2016.02.015; Chrzastek, K., Lee, D.H., Smith, D., Sharma, P., Suarez, D.L., Pantin-Jackwood, M., Kapczynski, D.R., Use of sequence-independent, single-primer-amplification (SISPA) for rapid detection, identification, and characterization of avian RNA viruses (2017) Virology, 509, pp. 159-166. , https://doi.org/10.1016/j.virol.2017.06.019; Chevreux, B., Wetter, T., Suhai, S., Genome sequence assembly using trace signals and additional sequence information (1999) Computer Science and Biology: Proceeding of the German Conference on Bioinformatics, GCB ‘99, pp. 45-56. , GCB, Hanover, Germany; Afgan, E., Baker, D., van den Beek, M., Blankenberg, D., Bouvier, D., Čech, M., Chilton, J., Goecks, J., The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2016 update (2016) Nucleic Acids Res, 44, pp. W3-W10. , https://doi.org/10.1093/nar/gkw343; Goraichuk, I.V., Kulkarni, A.B., Williams-Coplin, D., Suarez, D.L., Afonso, C.L., First complete genome sequence of currently circulating infectious bronchitis virus strain DMV/1639 of the GI-17 lineage (2019) Microbiol Resour Announc, 8, pp. e00840-e00919. , https://doi.org/10.1128/MRA.00840-19; Dimitrov, K.M., Sharma, P., Volkening, J.D., Goraichuk, I.V., Wajid, A., Rehmani, S.F., Basharat, A., Afonso, C.L., A robust and cost-effective approach to sequence and analyze complete genomes of small RNA viruses (2017) Virol J, 14, p. 72. , https://doi.org/10.1186/s12985-017-0741-5; Li, H., Durbin, R., Fast and accurate short read alignment with Burrows-Wheeler transform (2009) Bioinformatics, 25, pp. 1754-1760. , https://doi.org/10.1093/bioinformatics/btp324; Ammayappan, A., Upadhyay, C., Gelb, J., Vakharia, V.N., Complete genomic sequence analysis of infectious bronchitis virus Ark DPI strain and its evolution by recombination (2008) Virol J, 5, p. 157. , https://doi.org/10.1186/1743-422X-5-157; Ammayappan, A., Upadhyay, C., Gelb, J., Vakharia, V.N., Identification of sequence changes responsible for the attenuation of avian infectious bronchitis virus strain Arkansas DPI (2009) Arch Virol, 154, pp. 495-499. , https://doi.org/10.1007/s00705-009-0325-9","Suarez, D.L.; Exotic and Emerging Avian Viral Disease Research Unit, Southeast Poultry Research Laboratory, U.S. National Poultry Research Center, ARS, USDAUnited States; email: david.suarez@usda.gov",,American Society for Microbiology,2576098X,,,,English,Micro. Res. Ann,Article,Final,Open Access,Scopus,2-s2.0-85082472484,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhu G.D., Cao J.",57216097968;57213506786;,Challenges and countermeasures on Chinese malaria elimination programme during the coronavirus disease 2019 (COVID-19) outbreak,2020,Zhongguo xue xi chong bing fang zhi za zhi = Chinese journal of schistosomiasis control,32,1,,7,9,,,10.16250/j.32.1374.2020036,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082144683&doi=10.16250%2fj.32.1374.2020036&partnerID=40&md5=03f1f2ade993be3bfa5fc3c70c474401,"Jiangsu Institute of Parasitic Diseases; WHO Collaborating Center for Research and Training on Malaria Elimination; Key Laboratory of National Health Commission on Parasitic Disease Control and Prevention; Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Wuxi 214064, China","Zhu, G.D., Jiangsu Institute of Parasitic Diseases; WHO Collaborating Center for Research and Training on Malaria Elimination; Key Laboratory of National Health Commission on Parasitic Disease Control and Prevention; Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Wuxi 214064, China; Cao, J., Jiangsu Institute of Parasitic Diseases; WHO Collaborating Center for Research and Training on Malaria Elimination; Key Laboratory of National Health Commission on Parasitic Disease Control and Prevention; Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Wuxi 214064, China","[摘要] 2019年底以来, 一种新型冠状病毒病肺炎 (COVID-19) 在我国大范围流行, 不仅严重威胁人民群众的生命安全和身体健康, 同时也给其他传染病防控带来了严峻挑战。目前, 我国每年仍有近3 000例境外输入性疟疾病例, 如不能及时开展病例诊治和疫点调查处置, 不仅有可能危及患者生命, 还可能引起继发传播而威胁我国消除疟疾成果。新型冠状病毒肺炎流行范围广、传播能力强, 不仅疟疾患者在就医过程中有可能被感染, 而且医务人员在开展临床诊治、样本检测和流行病学调查时也面临感染风险。本文分析新型冠状病毒肺炎流行对我国消除疟疾工作的挑战, 并探讨相应的应对策略和措施, 从而为医务工作者提供参考。.Since the end of 2019, the coronavirus disease 2019 (COVID-19) has been extensively epidemic in China, which not only seriously threatens the safety and health of Chinese people, but also challenges the management of other infectious diseases. Currently, there are still approximately three thousand malaria cases imported into China every year. If the diagnosis and treatment of malaria cases as well as the investigation and response of the epidemic foci are not carried out timely, it may endanger patients'lives and cause the possible of secondary transmission, which threatens the achievements of malaria elimination in China. Due to the extensive spread and high transmission ability of the COVID-19, there is a possibility of virus infections among malaria cases during the medical care-seeking behaviors and among healthcare professionals during clinical diagnosis and treatment, sample collection and testing and epidemiological surveys. This paper analyzes the challenges of the COVID-19 for Chinese malaria elimination programme, and proposes the countermeasures in response to the COVID-19 outbreak, so as to provide the reference for healthcare professionals.",Challenge; Coronavirus disease 2019 (COVID-19); Countermeasure; Elimination; Malaria,"COVID-19; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; China; Coronavirus infection; epidemic; human; malaria; public health; virus pneumonia; Betacoronavirus; China; Coronavirus Infections; Disease Outbreaks; Humans; Malaria; National Health Programs; Pneumonia, Viral",,,,NLM (Medline),10056661,,,32185921,Chinese,Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi,Article,Final,,Scopus,2-s2.0-85082144683,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, [No author name available],[No author id available],"Erratum: Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: Retrospective case series (The BMJ (2020) 368 (m606) DOI:10.1136/bmj.m606)",2020,The BMJ,368,, m792,,,,,10.1136/bmj.m792,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081076439&doi=10.1136%2fbmj.m792&partnerID=40&md5=701dbd88c2b7cca81bb5d28386ecf00e,,,"The number and percentage of male patients should have been 35 (56%) under the heading All patients and 16 (55%) under the heading Time since symptom onset =10 days in table 1 and in the results. The number and percentage of patients with fever should have been 24 (73%) under the heading Time since symptom onset >10 days and 24 (83%) under the heading Time since symptom onset =10 days in table 1 and in the results. The exposure history heading in the left column of table 1 should have read Exposure history in Wuhan >2 weeks. Table 2 should have stated creatinine instead of creatine throughout. In the methods, the second paragraph of the Laboratory confirmation and treatment section should state that the dosage of arbidol should have read 200 mg three times daily. The paper will be updated in due course. © 2020 BMJ Publishing Group. All rights reserved.",,erratum,,,,BMJ Publishing Group,9598146,,BMJOA,32107200,English,BMJ,Erratum,Final,Open Access,Scopus,2-s2.0-85081076439,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Phan L.T., Nguyen T.V., Luong Q.C., Nguyen T.V., Nguyen H.T., Le H.Q., Nguyen T.T., Cao T.M., Pham Q.D.",54973476000;55366804500;57185431000;57214830737;57209589618;57215409311;57215417138;57211804333;55365037100;,Importation and human-to-human transmission of a novel coronavirus in Vietnam,2020,New England Journal of Medicine,382,9,,872,874,,24,10.1056/NEJMc2001272,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078864447&doi=10.1056%2fNEJMc2001272&partnerID=40&md5=ee0ad62bb00f58500a481602344c0b37,"Pasteur Institute Ho Chi Minh City, Ho Chi Minh City, Viet Nam; Cho Ray Hospital, Ho Chi Minh City, Viet Nam","Phan, L.T., Pasteur Institute Ho Chi Minh City, Ho Chi Minh City, Viet Nam; Nguyen, T.V., Pasteur Institute Ho Chi Minh City, Ho Chi Minh City, Viet Nam; Luong, Q.C., Pasteur Institute Ho Chi Minh City, Ho Chi Minh City, Viet Nam; Nguyen, T.V., Pasteur Institute Ho Chi Minh City, Ho Chi Minh City, Viet Nam; Nguyen, H.T., Pasteur Institute Ho Chi Minh City, Ho Chi Minh City, Viet Nam; Le, H.Q., Cho Ray Hospital, Ho Chi Minh City, Viet Nam; Nguyen, T.T., Cho Ray Hospital, Ho Chi Minh City, Viet Nam; Cao, T.M., Pasteur Institute Ho Chi Minh City, Ho Chi Minh City, Viet Nam; Pham, Q.D., Pasteur Institute Ho Chi Minh City, Ho Chi Minh City, Viet Nam",[No abstract available],,"antibiotic agent; antivirus agent; C reactive protein; COVID-19; severe acute respiratory syndrome coronavirus 2; 2019 novel coronavirus; adult; aged; blood oxygen tension; case report; clinical article; conservative treatment; coughing; dry cough; dyspnea; fatigue; fever; human; hypoxemia; importation; isolation; Letter; loose feces; lung infiltrate; male; marketing; medical history; oxygen therapy; priority journal; protein blood level; real time reverse transcription polymerase chain reaction; SARS coronavirus; thorax radiography; throat culture; Viet Nam; virus transmission; vomiting; Betacoronavirus; Coronavirus infection; diagnostic imaging; isolation and purification; lung; pathology; virus pneumonia; Adult; Aged; Betacoronavirus; Coronavirus Infections; Humans; Lung; Male; Pneumonia, Viral; Radiography, Thoracic","Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382, pp. 727-733; (2020) Novel Coronavirus (2019-nCoV): Situation Report - 5, 25 January 2020, , https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200125-sitrep-5-2019-ncov.pdf, Geneva: World Health Organization; Corman, V., Bleicker, T., Brünink, S., (2020) Diagnostic Detection of Wuhan Coronavirus 2019 by Real-time RT-PCR, , https://www.who.int/docs/default-source/coronaviruse/wuhan-virus-assay-v1991527e5122341d99287a1b17c111902.pdf, Geneva: World Health Organization, January 13; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, , https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30183-5/fulltext, January 24",,,Massachussetts Medical Society,284793,,NEJMA,31991079,English,New Engl. J. Med.,Letter,Final,Open Access,Scopus,2-s2.0-85078864447,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wang N., Shang J., Jiang S., Du L.",57211590912;57191992928;56491898300;8686996200;,Subunit Vaccines Against Emerging Pathogenic Human Coronaviruses,2020,Frontiers in Microbiology,11,,298,,,,,10.3389/fmicb.2020.00298,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082555769&doi=10.3389%2ffmicb.2020.00298&partnerID=40&md5=bf1f81e87d4a7e89f6555fefb90dee1c,"Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, United States; Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN, United States; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China","Wang, N., Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, United States; Shang, J., Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN, United States; Jiang, S., Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, United States, Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China; Du, L., Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, United States","Seven coronaviruses (CoVs) have been isolated from humans so far. Among them, three emerging pathogenic CoVs, including severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and a newly identified CoV (2019-nCoV), once caused or continue to cause severe infections in humans, posing significant threats to global public health. SARS-CoV infection in humans (with about 10% case fatality rate) was first reported from China in 2002, while MERS-CoV infection in humans (with about 34.4% case fatality rate) was first reported from Saudi Arabia in June 2012. 2019-nCoV was first reported from China in December 2019, and is currently infecting more than 70000 people (with about 2.7% case fatality rate). Both SARS-CoV and MERS-CoV are zoonotic viruses, using bats as their natural reservoirs, and then transmitting through intermediate hosts, leading to human infections. Nevertheless, the intermediate host for 2019-nCoV is still under investigation and the vaccines against this new CoV have not been available. Although a variety of vaccines have been developed against infections of SARS-CoV and MERS-CoV, none of them has been approved for use in humans. In this review, we have described the structure and function of key proteins of emerging human CoVs, overviewed the current vaccine types to be developed against SARS-CoV and MERS-CoV, and summarized recent advances in subunit vaccines against these two pathogenic human CoVs. These subunit vaccines are introduced on the basis of full-length spike (S) protein, receptor-binding domain (RBD), non-RBD S protein fragments, and non-S structural proteins, and the potential factors affecting these subunit vaccines are also illustrated. Overall, this review will be helpful for rapid design and development of vaccines against the new 2019-nCoV and any future CoVs with pandemic potential. This review was written for the topic of Antivirals for Emerging Viruses: Vaccines and Therapeutics in the Virology section of Frontiers in Microbiology. © Copyright © 2020 Wang, Shang, Jiang and Du.",2019-nCoV; human coronaviruses; MERS-CoV; pathogenesis; SARS-CoV; subunit vaccines,,"Adney, D.R., Wang, L., van Doremalen, N., Shi, W., Zhang, Y., Kong, W.P., Efficacy of an adjuvanted Middle East respiratory syndrome coronavirus spike protein vaccine in dromedary camels and alpacas (2019) Viruses, 11 (E212). , 30832356; Al-Amri, S.S., Abbas, A.T., Siddiq, L.A., Alghamdi, A., Sanki, M.A., Al-Muhanna, M.K., Immunogenicity of candidate MERS-CoV DNA vaccines based on the spike protein (2017) Sci. 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Virol, , [Epub ahead of print]; Zheng, N., Xia, R., Yang, C., Yin, B., Li, Y., Duan, C., Boosted expression of the SARS-CoV nucleocapsid protein in tobacco and its immunogenicity in mice (2009) Vaccine,27, pp. 5001-5007. , 19523911; Zhong, N.S., Zheng, B.J., Li, Y.M., Poon, L.L., Xie, Z.H., Chan, K.H., Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People’s Republic of China, in February, 2003 (2003) Lancet,362, pp. 1353-1358. , 14585636; Zhou, P., Yang, X.L., Wang, X.G., Hu, B., Zhang, L., Zhang, W., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature, , [Epub ahead of print], 32015507; Zhou, Y., Jiang, S., Du, L., Prospects for a MERS-CoV spike vaccine (2018) Expert Rev. Vaccines,17, pp. 677-686. , 30058403; Zhou, Y., Yang, Y., Huang, J., Jiang, S., Du, L., Advances in MERS-CoV vaccines and therapeutics based on the receptor-binding domain (2019) Viruses, 11 (E60). , 30646569; Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N. Engl. J. Med, , [Epub ahead of print]; Zhu, X., Liu, Q., Du, L., Lu, L., Jiang, S., Receptor-binding domain as a target for developing SARS vaccines (2013) J. Thoracic Dis,5, pp. S142-S148. ," 23977435""","Jiang, S.; Lindsley F. Kimball Research Institute, New York Blood CenterUnited States; email: shibojiang@fudan.edu.cn",,Frontiers Media S.A.,1664302X,,,,English,Front. Microbiol.,Review,Final,Open Access,Scopus,2-s2.0-85082555769,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Jernigan D.B., CDC COVID-19 Response Team",57209456768;,"Update: Public Health Response to the Coronavirus Disease 2019 Outbreak - United States, February 24, 2020",2020,MMWR. Morbidity and mortality weekly report,69,8,,216,219,,1,10.15585/mmwr.mm6908e1,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080959363&doi=10.15585%2fmmwr.mm6908e1&partnerID=40&md5=98d8715e7df1c50405d5a63b1e75f842,CDC,"Jernigan, D.B., CDC; CDC COVID-19 Response Team","An outbreak of coronavirus disease 2019 (COVID-19) caused by the 2019 novel coronavirus (SARS-CoV-2) began in Wuhan, Hubei Province, China in December 2019, and has spread throughout China and to 31 other countries and territories, including the United States (1). As of February 23, 2020, there were 76,936 reported cases in mainland China and 1,875 cases in locations outside mainland China (1). There have been 2,462 associated deaths worldwide; no deaths have been reported in the United States. Fourteen cases have been diagnosed in the United States, and an additional 39 cases have occurred among repatriated persons from high-risk settings, for a current total of 53 cases within the United States. This report summarizes the aggressive measures (2,3) that CDC, state and local health departments, multiple other federal agencies, and other partners are implementing to slow and try to contain transmission of COVID-19 in the United States. These measures require the identification of cases and contacts of persons with COVID-19 in the United States and the recommended assessment, monitoring, and care of travelers arriving from areas with substantial COVID-19 transmission. Although these measures might not prevent widespread transmission of the virus in the United States, they are being implemented to 1) slow the spread of illness; 2) provide time to better prepare state and local health departments, health care systems, businesses, educational organizations, and the general public in the event that widespread transmission occurs; and 3) better characterize COVID-19 to guide public health recommendations and the development and deployment of medical countermeasures, including diagnostics, therapeutics, and vaccines. U.S. public health authorities are monitoring the situation closely, and CDC is coordinating efforts with the World Health Organization (WHO) and other global partners. Interim guidance is available at https://www.cdc.gov/coronavirus/index.html. As more is learned about this novel virus and this outbreak, CDC will rapidly incorporate new knowledge into guidance for action by CDC, state and local health departments, health care providers, and communities.",,"severe acute respiratory syndrome coronavirus 2; airport; Betacoronavirus; contact examination; Coronavirus infection; epidemic; human; isolation and purification; laboratory; mass screening; practice guideline; public health service; travel related disease; United States; virology; Airports; Betacoronavirus; Centers for Disease Control and Prevention, U.S.; Contact Tracing; Coronavirus Infections; Disease Outbreaks; Humans; Laboratories; Mass Screening; Practice Guidelines as Topic; Public Health Practice; Travel-Related Illness; United States",,,,NLM (Medline),1545861X,,,32106216,English,MMWR Morb. Mortal. Wkly. Rep.,Article,Final,Open Access,Scopus,2-s2.0-85080959363,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Chen T.-M., Rui J., Wang Q.-P., Zhao Z.-Y., Cui J.-A., Yin L.",57210266960;57210859874;57215413492;57201256692;7401811599;36660069800;,A mathematical model for simulating the phase-based transmissibility of a novel coronavirus,2020,Infectious Diseases of Poverty,9,1,24,,,,,10.1186/s40249-020-00640-3,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080859882&doi=10.1186%2fs40249-020-00640-3&partnerID=40&md5=9ba3dacdf7c07f39447a7d1e617e48d2,"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, 4221-117 South Xiang'an Road, Xiang'an District, Xiamen, Fujian Province, China; Department of Mathematics, School of Science, Beijing University of Civil Engineering and Architecture, Beijing, China; Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong Province, China","Chen, T.-M., State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, 4221-117 South Xiang'an Road, Xiang'an District, Xiamen, Fujian Province, China; Rui, J., State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, 4221-117 South Xiang'an Road, Xiang'an District, Xiamen, Fujian Province, China; Wang, Q.-P., State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, 4221-117 South Xiang'an Road, Xiang'an District, Xiamen, Fujian Province, China; Zhao, Z.-Y., State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, 4221-117 South Xiang'an Road, Xiang'an District, Xiamen, Fujian Province, China; Cui, J.-A., Department of Mathematics, School of Science, Beijing University of Civil Engineering and Architecture, Beijing, China; Yin, L., Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong Province, China","Background: As reported by the World Health Organization, a novel coronavirus (2019-nCoV) was identified as the causative virus of Wuhan pneumonia of unknown etiology by Chinese authorities on 7 January, 2020. The virus was named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by International Committee on Taxonomy of Viruses on 11 February, 2020. This study aimed to develop a mathematical model for calculating the transmissibility of the virus. Methods: In this study, we developed a Bats-Hosts-Reservoir-People transmission network model for simulating the potential transmission from the infection source (probably be bats) to the human infection. Since the Bats-Hosts-Reservoir network was hard to explore clearly and public concerns were focusing on the transmission from Huanan Seafood Wholesale Market (reservoir) to people, we simplified the model as Reservoir-People (RP) transmission network model. The next generation matrix approach was adopted to calculate the basic reproduction number (R 0) from the RP model to assess the transmissibility of the SARS-CoV-2. Results: The value of R 0 was estimated of 2.30 from reservoir to person and 3.58 from person to person which means that the expected number of secondary infections that result from introducing a single infected individual into an otherwise susceptible population was 3.58. Conclusions: Our model showed that the transmissibility of SARS-CoV-2 was higher than the Middle East respiratory syndrome in the Middle East countries, similar to severe acute respiratory syndrome, but lower than MERS in the Republic of Korea. © 2020 The Author(s).",Basic reproduction number; Mathematical model; Next generation matrix; Novel coronavirus; Transmissibility,"2019 novel coronavirus; Article; computer simulation; Coronavirinae; coronavirus disease 2019; disease carrier; high throughput sequencing; human; incubation time; infection risk; mathematical model; mortality rate; nonhuman; priority journal; SARS coronavirus; secondary infection; virus transmission; animal; bat; Betacoronavirus; Coronavirus infection; disease transmission; growth, development and aging; theoretical model; time factor; veterinary medicine; virology; virus pneumonia; COVID-19; severe acute respiratory syndrome coronavirus 2; Animals; Betacoronavirus; Chiroptera; Coronavirus Infections; Disease Reservoirs; Disease Transmission, Infectious; Humans; Models, Theoretical; Pneumonia, Viral; Time Factors","(2020) Coronavirus, , https://www.who.int/health-topics/coronavirus, World Health Organization, World Health Organization, cited January 19; Zhou, P., Yang, X.L., Wang, X.G., Hu, B., Zhang, L., Zhang, W., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature, , https://doi.org/10.1038/s41586-020-2012-7; Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med., , https://doi.org/10.1056/NEJMoa2001316; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Yi., Zhang, Li., Cao, B., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) The Lancet, 395 (1223), pp. 497-506; Chan, J.F.-W., Yuan, S., Kok, K.-H., To, K.K.-W., Chu, H., Yang, J., Xing, F., Yuen, K.-Y., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: A study of a family cluster (2020) The Lancet, 395 (1223), pp. 514-523; Zhu, Na., Zhang, D., Wang, W., Li, X., Yang, Bo., Song, J., Zhao, X., Tan, W., A Novel Coronavirus from Patients with Pneumonia in China, 2019 (2020) New England Journal of Medicine, 382 (8), pp. 727-733. , 1:CAS:528:DC%2BB3cXjslGmsrc%3D; Bogoch, I.I., Watts, A., Thomas-Bachli, A., Huber, C., Mug, K., Khan, K., Pneumonia of unknown etiology in Wuhan, China: Potential for International Spread Via Commercial Air Travel (2020) J Travel Med., , https://doi.org/10.1093/jtm/taaa008; Wu, J.T., Leung, K., Leung, G.M., Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: A modelling study (2020) The Lancet, 395 (1225), pp. 689-697; Zhao, S., Lin, Q., Ran, J., Musa, S.S., Yang, G., Wang, W., Lou, Y., Wang, M.H., Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: A data-driven analysis in the early phase of the outbreak (2020) International Journal of Infectious Diseases, 92, pp. 214-217; Zhao, Musa, Lin, Ran, Yang, Wang, Lou, Wang, Estimating the Unreported Number of Novel Coronavirus (2019-nCoV) Cases in China in the First Half of January 2020: A Data-Driven Modelling Analysis of the Early Outbreak (2020) Journal of Clinical Medicine, 9 (2), p. 388; (2020) Novel Coronavirus-China, , https://www.who.int/csr/don/12-january-2020-novel-coronavirus-china/en/, World Health Organization, World Health Organization. cited January 20, Accessed 20 Jan 2020; Chen, T., Rui, J., Wang, Q., Zhao, Z., Cui, J.-A., Yin, L., A mathematical model for simulating the transmission of Wuhan novel Coronavirus (2020) BioRxiv., 2020. , 2001.2019.911669. 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Dis. Pover.,Article,Final,Open Access,Scopus,2-s2.0-85080859882,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Cohen J., Kupferschmidt K.",57203682506;37095697200;,"Strategies shift as coronavirus pandemic looms: The virus seems unstoppable, but mitigating its speed and impact is possible",2020,Science,367,6481,,962,963,,1,10.1126/science.367.6481.962,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080950913&doi=10.1126%2fscience.367.6481.962&partnerID=40&md5=135b8b681d16d4e83e060d221c370c38,,"Cohen, J.; Kupferschmidt, K.",[No abstract available],,aviation; China; Coronavirus infection; COVID 19; disease surveillance; economic aspect; hand washing; health care availability; health care system; home environment; human; infection control; infection prevention; mortality; Note; pandemic; physical well-being; priority journal; psychological well-being; public health; public health message; quarantine; travel restriction; virus transmission; World Health Organization; Coronavirus,,,,American Association for the Advancement of Science,368075,,SCIEA,32108093,English,Sci.,Note,Final,Open Access,Scopus,2-s2.0-85080950913,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Fisher D., Heymann D.",7403343741;7103238630;,Q&A: The novel coronavirus outbreak causing COVID-19,2020,BMC Medicine,18,1,57,,,,,10.1186/s12916-020-01533-w,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080881105&doi=10.1186%2fs12916-020-01533-w&partnerID=40&md5=4f89a43b152968588efc34385a35f364,"Division of infectious Diseases, University Medicine Cluster, National University Health Systems, Singapore, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; London School of Hygiene and Tropical Medicine, London, United Kingdom","Fisher, D., Division of infectious Diseases, University Medicine Cluster, National University Health Systems, Singapore, Singapore, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Heymann, D., London School of Hygiene and Tropical Medicine, London, United Kingdom",[No abstract available],,"antivirus agent; COVID-19; severe acute respiratory syndrome coronavirus 2; vaccine; coronavirus disease 2019; Coronavirus infection; coughing; diarrhea; disease severity; disease transmission; dry cough; epidemic; extracorporeal oxygenation; fatigue; fever; gene sequence; genetic analysis; hand washing; human; immunogenicity; influenza A (H1N1); nonhuman; nose obstruction; Note; risk assessment; SARS coronavirus; sequence homology; serology; Severe acute respiratory syndrome coronavirus 2; sore throat; symptomatology; artificial ventilation; Betacoronavirus; Coronavirus infection; differential diagnosis; global health; health service; migration; pathogenicity; travel; virus pneumonia; World Health Organization; Antiviral Agents; Betacoronavirus; Coronavirus Infections; Diagnosis, Differential; Disease Outbreaks; Emigration and Immigration; Global Health; Humans; Pneumonia, Viral; Respiration, Artificial; Travel; Vaccines; Voluntary Health Agencies; World Health Organization","Zhou, P., Yang, X., Wang, X., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature, , 10.1038/s41586-020-2012-7 32094661; (2020) Phylogenetic analysis, , http://virological.org/t/phylodynamic-analysis-90-genomes-12-feb-2020/356, Accessed 17 Feb; The Epidemiological Characteristics of an Outbreak of 2019 Novel Coronavirus Diseases (COVID-19) - China, 2020 (2020) China CDC Weekly, 2 (8), pp. 113-122. , The Novel Coronavirus Pneumonia Emergency Response Epidemiology Team; Patel, A., Jernigan, D.B., Abdirizak, F., Abedi, G., Aggarwal, S., Albina, D., Allen, E., Yousef, A., Initial Public Health Response and Interim Clinical Guidance for the 2019 Novel Coronavirus Outbreak - United States, December 31, 2019-February 4, 2020 (2020) MMWR. Morbidity and Mortality Weekly Report, 69 (5), pp. 140-146; Heymann, D.L., Shindo, N., COVID-19: what is next for public health? (2020) The Lancet, 395 (10224), pp. 542-545; Li G, De Clercq, E., Therapeutic options for the 2019 novel coronavirus (2019-nCoV) (2020) Nat Rev Drug Discov, , https://doi.org/10.1038/d41573-020-00016-0; Stockman, L.J., Bellamy, R., Garner, P., SARS: Systematic Review of Treatment Effects (2006) PLoS Medicine, 3 (9), p. e343","Fisher, D.; Division of infectious Diseases, University Medicine Cluster, National University Health SystemsSingapore; email: mdcfda@nus.edu.sg",,BioMed Central Ltd.,17417015,,,32106852,English,BMC Med.,Note,Final,Open Access,Scopus,2-s2.0-85080881105,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Poland G.A.,7006264623;,"Another coronavirus, another epidemic, another warning",2020,Vaccine,38,10,,v,vi,,,10.1016/j.vaccine.2020.02.039,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079688117&doi=10.1016%2fj.vaccine.2020.02.039&partnerID=40&md5=e28aade65f4a9d746be4ab299454943e,"Mary Lowell Leary Emeritus Professor of Medicine, United States; Distinguished Investigator of the Mayo Clinic, United States; Director, Mayo Vaccine Research Group, United States; Mayo Clinic, Rochester, MN, United States","Poland, G.A., Mary Lowell Leary Emeritus Professor of Medicine, United States, Distinguished Investigator of the Mayo Clinic, United States, Director, Mayo Vaccine Research Group, United States, Mayo Clinic, Rochester, MN, United States",[No abstract available],,antivirus agent; virus vaccine; 2019 novel coronavirus; China; Coronavirinae; Coronavirus infection; disease surveillance; disease transmission; drug development; drug efficacy; Editorial; epidemic; food handling; hand washing; health care cost; human; immunoimmaturity; immunopathology; immunosensecence; infection control; infection prevention; Middle East respiratory syndrome coronavirus; mortality rate; nonhuman; priority journal; public health service; SARS coronavirus; upper respiratory tract infection,,,,Elsevier Ltd,0264410X,,VACCD,32089242,English,Vaccine,Editorial,Final,Open Access,Scopus,2-s2.0-85079688117,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Li Y., Hu L., Chen T., Chang M., Deng F., Hu Z., Wang H., Wang M.",57202267814;57202263731;57215714420;57207570191;35847541100;7404210963;55688939700;24529212300;,Host AAA+ ATPase TER94 Plays Critical Roles in Building the Baculovirus Viral Replication Factory and Virion Morphogenesis,2020,Journal of virology,94,6,,,,,,10.1128/JVI.01674-19,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081069098&doi=10.1128%2fJVI.01674-19&partnerID=40&md5=04f97542fd49e576f903d5be9785f901,"State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China; University of Chinese Academy of SciencesBeijing, China; State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China","Li, Y., State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China; Hu, L., State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China; Chen, T., State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China, University of Chinese Academy of SciencesBeijing, China; Chang, M., State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China, University of Chinese Academy of SciencesBeijing, China; Deng, F., State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China; Hu, Z., State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China; Wang, H., State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China; Wang, M., State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China","TER94 is a multifunctional AAA+ ATPase crucial for diverse cellular processes, especially protein quality control and chromatin dynamics in eukaryotic organisms. Many viruses, including coronavirus, herpesvirus, and retrovirus, coopt host cellular TER94 for optimal viral invasion and replication. Previous proteomics analysis identified the association of TER94 with the budded virions (BVs) of baculovirus, an enveloped insect large DNA virus. Here, the role of TER94 in the prototypic baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV) life cycle was investigated. In virus-infected cells, TER94 accumulated in virogenic stroma (VS) at the early stage of infection and subsequently partially rearranged in the ring zone region. In the virions, TER94 was associated with the nucleocapsids of both BV and occlusion-derived virus (ODV). Inhibition of TER94 ATPase activity significantly reduced viral DNA replication and BV production. Electron/immunoelectron microscopy revealed that inhibition of TER94 resulted in the trapping of nucleocapsids within cytoplasmic vacuoles at the nuclear periphery for BV formation and blockage of ODV envelopment at a premature stage within infected nuclei, which appeared highly consistent with its pivotal function in membrane biogenesis. Further analyses showed that TER94 was recruited to the VS or subnuclear structures through interaction with viral early proteins LEF3 and helicase, whereas inhibition of TER94 activity blocked the proper localization of replication-related viral proteins and morphogenesis of VS, providing an explanation for its role in viral DNA replication. Taken together, these data indicated the crucial functions of TER94 at multiple steps of the baculovirus life cycle, including genome replication, BV formation, and ODV morphogenesis.IMPORTANCE TER94 constitutes an important AAA+ ATPase that associates with diverse cellular processes, including protein quality control, membrane fusion of the Golgi apparatus and endoplasmic reticulum network, nuclear envelope reformation, and DNA replication. To date, little is known regarding the role(s) of TER94 in the baculovirus life cycle. In this study, TER94 was found to play a crucial role in multiple steps of baculovirus infection, including viral DNA replication and BV and ODV formation. Further evidence showed that the membrane fission/fusion function of TER94 is likely to be exploited by baculovirus for virion morphogenesis. Moreover, TER94 could interact with the viral early proteins LEF3 and helicase to transport and further recruit viral replication-related proteins to establish viral replication factories. This study highlights the critical roles of TER94 as an energy-supplying chaperon in the baculovirus life cycle and enriches our knowledge regarding the biological function of this important host factor. Copyright © 2020 American Society for Microbiology.",AAA+ ATPase; baculovirus; BV production; DNA replication; helicase; LEF3; ODV morphogenesis; TER94; virogenic stroma,"adenosine triphosphatase; DNA binding protein; DNA helicase; late expression factor 3, baculovirus; viral protein; virus DNA; animal; biosynthesis; cell nucleus; cell vacuole; cytoplasm; host pathogen interaction; metabolism; physiology; Sf9 cell line; virion; virology; virus nucleocapsid; virus replication; Adenosine Triphosphatases; Animals; Cell Nucleus; Cytoplasm; DNA Helicases; DNA, Viral; DNA-Binding Proteins; Host-Pathogen Interactions; Nucleocapsid; Nucleopolyhedroviruses; Sf9 Cells; Vacuoles; Viral Proteins; Virion; Virus Replication",,,,NLM (Medline),10985514,,,31896597,English,J. Virol.,Article,Final,Open Access,Scopus,2-s2.0-85081069098,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Chen J., Zhang Y., Niu P., Lu R., Zhu N., Fan H., Tan W.",57203334768;57201559903;56096165800;57215905151;56992193500;55513104400;7401959748;,Effects of sample processing modes on high-throughput sequencing of coronavirus whole genome [不同样本测序前处理方案对冠状病毒基因组高通量测序结果的影响],2020,Chinese Journal of Microbiology and Immunology (China),40,2,,103,109,,,10.3760/cma.j.cn112309-20191011-00322,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082317171&doi=10.3760%2fcma.j.cn112309-20191011-00322&partnerID=40&md5=087e08e2eae5dd099bbaf7873406d86c,"Institute of Medical Virology, Zhejiang Provincial Key Laboratory of Medical Genetics, Key Laboratory of Laboratory Medicine of Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325035, China; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing, 100071, China; NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China","Chen, J., Institute of Medical Virology, Zhejiang Provincial Key Laboratory of Medical Genetics, Key Laboratory of Laboratory Medicine of Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325035, China; Zhang, Y., State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing, 100071, China; Niu, P., NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China; Lu, R., NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China; Zhu, N., NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China; Fan, H., State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing, 100071, China; Tan, W., Institute of Medical Virology, Zhejiang Provincial Key Laboratory of Medical Genetics, Key Laboratory of Laboratory Medicine of Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325035, China","Objective: To study the effects of different pre-sequencing sample processing modes on the results of whole genome sequencing with high-throughput sequencing (HTS) by taking the largest RNA virus (human coronavirus, HCoV) as the representative. Methods: Cell-cultured human coronavirus HCoV-OC43 strains were used as the representative samples and divided into different groups based on pre-sequencing processing modes as follows: untreated group, DNase and RNase treatment before nucleic acid extraction group, DNase treatment after nucleic acid extraction group, and DNase and RNase treatment before nucleic acid extraction and DNase treatment after nucleic acid extraction group. Nucleic acid samples of each group were analyzed by direct RNA sequencing (without amplification) and DNA sequencing after sequence independent single primer amplification (SISPA), respectively. Results: No significant difference in viral genome coverage rates was observed between different groups. The highest genome coverage and sequencing accuracy were obtained in DNase treatment after nucleic acid extraction group by direct RNA sequencing, and the ratio of viral reads and the sequencing depth of each locus were effectively improved by SISPA amplification. Conclusions: This study provided an optimized technical strategy for whole genome sequencing of RNA viruses such as coronavirus. Copyright © 2020 by the Chinese Medical Association.",High-throughput sequencing; Human coronavirus; Sequence independent single primer amplification; Whole genome sequencing,,"Chiu, C.Y., Viral pathogen discovery (2013) Curr Opin Microbiol, 16 (4), pp. 468-478; Moustafa, A., Xie, C., Kirkness, E., The blood DNA virome in 8,000 humans (2017) PLoS Pathog, 13 (3); Hampton-Marcell, J.T., Lopez, J.V., Gilbert, J.A., The human microbiome: an emerging tool in forensics (2017) Microb Biotechnol, 10 (2), pp. 228-230; Metsky, H.C., Siddle, K.J., Gladden-Young, A., Capturing sequence diversity in metagenomes with comprehensive and scalable probe design (2019) Nat Biotechnol, 37 (2), pp. 160-168; Blauwkamp, T.A., Thair, S., Rosen, M.J., Analytical and clinical validation of a microbial cell-free DNA sequencing test for infectious disease (2019) Nat Microbiol, 4 (4), pp. 663-674; Wilson, M.R., Naccache, S.N., Samayoa, E., Actionable diagnosis of neuroleptospirosis by next-generation sequencing (2014) N Engl J Med, 370 (25), pp. 2408-2417; Joyjinda, Y., Rodpan, A., Chartpituck, P., First complete genome sequence of human coronavirus HKU1 from a nonill bat guano miner in Thailand (2019) Microbiol Resour Announc, 8 (6); Jones, M.S., Kapoor, A., Lukashov, V.V., New DNA viruses identified in patients with acute viral infection syndrome (2005) J Virol, 79 (13), pp. 8230-8236; Woo, P.C., Lau, S.K., Huang, Y., Coronavirus diversity, phylogeny and interspecies jumping (2009) Exp Biol Med (Maywood), 234 (10), pp. 1117-1127; Al-Khannaq, M.N., Ng, K.T., Oong, X.Y., Diversity and evolutionary histories of human coronaviruses NL63 and 229E associated with acute upper respiratory tract symptoms in kuala lumpur, Malaysia (2016) Am J Trop Med Hyg, 94 (5), pp. 1058-1064; O’flaherty, B.M., Li, Y., Tao, Y., Comprehensive viral enrichment enables sensitive respiratory virus genomic identification and analysis by next generation sequencing (2018) Genome Res, 28 (6), pp. 869-877; Houldcroft, C.J., Beale, M.A., Breuer, J., Clinical and biological insights from viral genome sequencing (2017) Nat Rev Microbiol, 15 (3), pp. 183-192; Karlsson, O.E., Belák, S., Granberg, F., The effect of preprocessing by sequence-independent, single-primer amplification (SISPA) on metagenomic detection of viruses (2013) Biosecur Bioterror, 11, pp. S227-S234; Brown, J., Pirrung, M., Mccue, L.A., FQC dashboard: integrates FastQC results into a web-based, interactive, and extensible FASTQ quality control tool (2017) Bioinformatics; Bolger, A.M., Lohse, M., Usadel, B., Trimmomatic: a flexible trimmer for Illumina sequence data (2014) Bioinformatics, 30 (15), pp. 2114-2120; Loman, N.J., Misra, R.V., Dallman, T.J., Performance comparison of benchtop high-throughput sequencing platforms (2012) Nat Biotechnol, 30 (5), pp. 434-439; Luo, R., Liu, B., Xie, Y., SOAPdenovo2: an empirically improved memory-efficient short-read de novo assembler (2012) Gigascience, 1 (1), p. 18; Narasimhan, V., Danecek, P., Scally, A., BCFtools/RoH: a hidden Markov model approach for detecting autozygosity from next-generation sequencing data (2016) Bioinformatics, 32 (11), pp. 1749-1751; Rosseel, T., Ozhelvaci, O., Freimanis, G., Evaluation of convenient pretreatment protocols for RNA virus metagenomics in serum and tissue samples (2015) J Virol Methods, 222, pp. 72-80; Maurier, F., Beury, D., Fléchon, L., A complete protocol for whole-genome sequencing of virus from clinical samples: Application to coronavirus OC43 (2019) Virology, 531, pp. 141-148; Allander, T., Emerson, S.U., Engle, R.E., A virus discovery method incorporating DNase treatment and its application to the identification of two bovine parvovirus species (2001) Proc Natl Acad Sci USA, 98 (20), pp. 11609-11614; Greninger, A.L., Chen, E.C., Sittler, T., A metagenomic analysis of pandemic influenza A (2009 H1N1) infection in patients from North America (2010) PLoS One, 5 (10); Le-Coupanec, A., Desforges, M., Meessen-Pinard, M., Cleavage of a neuroinvasive human respiratory virus spike glycoprotein by proprotein convertases modulates neurovirulence and virus spread within the central nervous system (2015) PLoS Pathog, 11 (11)","Tan, W.; Institute of Medical Virology, Zhejiang Provincial Key Laboratory of Medical Genetics, Key Laboratory of Laboratory Medicine of Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical UniversityChina; email: tanwj28@163.com",,Society of Microbiology and Immunology,2545101,,ZWMZD,,Chinese,Chin. J. Microbiol. Immunol.,Article,Final,,Scopus,2-s2.0-85082317171,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, [No author name available],[No author id available],"Department of Error: First imported case of 2019 novel coronavirus in Canada, presenting as mild pneumonia (The Lancet (2020) 395(10225) (734), (S0140673620303706), (10.1016/S0140-6736(20)30370-6))",2020,The Lancet,395,10225,,e41,,,,10.1016/S0140-6736(20)30423-2,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080845809&doi=10.1016%2fS0140-6736%2820%2930423-2&partnerID=40&md5=4d2d23df55576865212f5865e604fa83,,,"Silverstein WK, Stroud L, Cleghorn GE, Leis JA. First imported case of 2019 novel coronavirus in Canada, presenting as mild pneumonia. Lancet 2020; 395: 734—In this Clinical Picture, the last sentence should have read: “Further, it suggests that the identification of individuals—like our patient—who could be managed by being isolated at home, rather than in hospital, might be an important strategy for containing this outbreak.” This correction has been made to the online version as of Feb 27, 2020, and the printed version is correct. © 2020 Elsevier Ltd",,erratum,,,,Lancet Publishing Group,1406736,,LANCA,,English,Lancet,Erratum,Final,Open Access,Scopus,2-s2.0-85080845809,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Cheng Y., Cao X., Qin L.",57215903584;57215900299;56272601900;,Progress in cross-species transmission of human coronaviruses (HCoVs) [人冠状病毒跨种传播的研究进展],2020,Chinese Journal of Microbiology and Immunology (China),40,2,,146,153,,,10.3760/cma.j.cn112309-20200209-00054,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082338381&doi=10.3760%2fcma.j.cn112309-20200209-00054&partnerID=40&md5=abe2df4122aeb8f909835a939c61e996,"Department of Emergency, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, 450000, China; Department of Rheumatology and Immunology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, 450000, China","Cheng, Y., Department of Emergency, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, 450000, China; Cao, X., Department of Rheumatology and Immunology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, 450000, China; Qin, L., Department of Emergency, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, 450000, China","Coronaviruses (CoVs) are a group of ancient and common viruses, posing a severe threat to the health of humans and other animals. Currently, seven human CoVs (HCoVs) have been identified. They are all animal-derived zoonotic pathogens that jump the species barrier from their natural host animals to humans in a direct or indirect manner and lead to interpersonal transmission. The receptor binding domain (RBD) on the S1 subunit of CoV spike (S) protein is one of the key factors determining the cross-species transmission and the invasion potential. This review summarized and analyzed the transmission modes of seven HCoVs and the available structures of HCoV-RBD that mediated the cross-species transmission in order to better understanding the mechanism of CoV cross-species transmission and providing valuable knowledge in response to the potential cross-species transmission of novel CoVs in the future. Copyright © 2020 by the Chinese Medical Association.",C-terminal domain (CTD); Cross-species transmission; Human coronavirus (HCoV); Receptor binding domain (RBD); Spike (S) protein; Structure,carboxy terminal sequence; Coronavirinae; human; infectious agent; natural host; nonhuman; protein domain; receptor binding; review; spike,"Adams, M.J., Carstens, E.B., Ratification vote on taxonomic proposals to the International Committee on Taxonomy of Viruses (2012) (2012) Arch Virol, 157 (7), pp. 1411-1422; De-Groot, R.J., Baker, S.C., Baric, R.S., Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group (2013) J Virol, 87 (14), pp. 7790-7792; Zhu, R.N., Xing, J.F., Qian, Y., Sequence analysis and prediction of related B cell epitopes of membrane protein(M) of human coronavirus NL63 (2007) Chin J Microbiol Immunol, 27 (9), pp. 775-778. , 朱汝南,邢江峰,钱渊,等. 新型人冠状病毒nl63膜蛋白(m)基因的序列分析及其抗原表位预测分析[J]. 中华微生物学和免疫学杂志,2007, 27(9): 775-778. ; Pene, F., Merlat, A., Vabret, A., Coronavirus 229E-related pneumonia in immunocompromised patients (2003) Clin Infect Dis, 37 (7), pp. 929-932; 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Lau, S.K., Woo, P.C., Li, K.S., Discovery of a novel coronavirus, China Rattus coronavirus HKU24, from Norway rats supports the murine origin of Betacoronavirus 1 and has implications for the ancestor of Betacoronavirus lineage A (2015) J Virol, 89 (6), pp. 3076-3092; Forni, D., Cagliani, R., Clerici, M., Molecular evolution of human coronavirus genomes (2017) Trends Microbiol, 25 (1), pp. 35-48; Qian, Z., Ou, X., Góes, L.G., Identification of the receptor-binding domain of the spike glycoprotein of human betacoronavirus HKU1 (2015) J Virol, 89 (17), pp. 8816-8827; Ou, X., Guan, H., Qin, B., Crystal structure of the receptor binding domain of the spike glycoprotein of human betacoronavirus HKU1 (2017) Nat Commun, 8, p. 15216; Wang, Y.D., Qiu, L.W., Miao, Z.Y., Serological relationships of the human coronavirus strains 229E, OC43 and SARS-CoV (2006) Chin J Microbiol Immunol, 26 (8), pp. 747-751. , 王压娣,丘立文,廖志勇,等. 人冠状病毒229E, OC43与SARS-CoV血清学相关性的研究[J]. 中华微生物学和免疫学杂志,2006, 26(8): 747-751. ; Künkel, F., Herrler, G., Structural and functional analysis of the surface protein of human coronavirus OC43 (1993) Virology, 195 (1), pp. 195-202; Peng, G., Xu, L., Lin, Y.L., Crystal structure of bovine coronavirus spike protein lectin domain (2012) J Biol Chem, 287 (50), pp. 41931-41938; Peng, G., Sun, D., Rajashankar, K.R., Crystal structure of mouse coronavirus receptor-binding domain complexed with its murine receptor (2011) Proc Natl Acad Sci USA, 108 (26), pp. 10696-10701; Hulswit, R.J.G., Lang, Y., Bakkers, M.J.G., Human coronaviruses OC43 and HKU1 bind to 9-O-acetylated sialic acids via a conserved receptor-binding site in spike protein domain A (2019) Proc Natl Acad Sci USA, 116 (7), pp. 2681-2690; Lau, S.K., Li, K.S., Tsang, A.K., Genetic characterization of Betacoronavirus lineage C viruses in bats reveals marked sequence divergence in the spike protein of pipistrellus bat coronavirus HKU5 in Japanese pipistrelle: implications for the origin of the novel Middle East respiratory syndrome coronavirus (2013) J Virol, 87 (15), pp. 8638-8650; Zhang, Z., Shen, L., Gu, X., Evolutionary Dynamics of MERS-CoV: Potential Recombination, Positive Selection and Transmission (2016) Sci Rep, 6, p. 25049; World Health Organization, Middle East respiratory syndrome coronavirus (MERS-CoV) (2019), https://www.who.int/emergencies/mers-cov/en/; Raj, V.S., Mou, H., Smits, S.L., Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC (2013) Nature, 495 (7440), pp. 251-254; Xu, X., Chen, P., Wang, J., Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission (2020) Sci China Life Sci; Zhou, P., Yang, X.L., Wang, X.G., Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin (2020) BioRxiv, , https://doi.org/10.1101/2020.01.22.914952; Li, X., Wang, W., Zhao, X., Transmission dynamics and evolutionary history of 2019-nCoV (2020) J Med Virol; Lu, G., Wang, Q., Gao, G.F., Bat-to-human: spike features determining 'host jump’ of coronaviruses SARS-CoV, MERS-CoV, and beyond (2015) Trends Microbiol, 23 (8), pp. 468-478; Wrapp, D., Wang, N.S., Corbett, K.S., Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation (2020) Science","Qin, L.; Department of Emergency, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan UniversityChina; email: qinlijie1819@163.com",,Society of Microbiology and Immunology,2545101,,ZWMZD,,Chinese,Chin. J. Microbiol. Immunol.,Review,Final,,Scopus,2-s2.0-85082338381,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Čivljak R., Markotić A., Kuzman I.",7801604292;7003721055;7003989809;,The third coronavirus epidemic in the third millennium: what's next?,2020,Croatian medical journal,61,1,,1,4,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080839340&partnerID=40&md5=85fb9d605d1f7ecaa20610714d4d46a2,"University of Zagreb School of Medicine, Zagreb, Croatia","Čivljak, R., University of Zagreb School of Medicine, Zagreb, Croatia; Markotić, A.; Kuzman, I.",[No abstract available],,,,,,NLM (Medline),13328166,,,32118371,English,Croat. Med. J.,Editorial,Final,,Scopus,2-s2.0-85080839340,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Silverstein W.K., Stroud L., Cleghorn G.E., Leis J.A.",56829346100;10144936200;57215080261;36988569700;,"First imported case of 2019 novel coronavirus in Canada, presenting as mild pneumonia",2020,The Lancet,395,10225,,734,,,3,10.1016/S0140-6736(20)30370-6,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079904368&doi=10.1016%2fS0140-6736%2820%2930370-6&partnerID=40&md5=39ceb259b24a5103740b3ddd2bfc51f5,"Department of Medicine, University of Toronto, Toronto, ON, Canada; Division of General Internal Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Division of Emergency Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Division of Infectious Diseases, Sunnybrook Health Sciences Centre, Toronto, ON, Canada","Silverstein, W.K., Department of Medicine, University of Toronto, Toronto, ON, Canada; Stroud, L., Department of Medicine, University of Toronto, Toronto, ON, Canada, Division of General Internal Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Cleghorn, G.E., Department of Medicine, University of Toronto, Toronto, ON, Canada, Division of Emergency Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada; Leis, J.A., Department of Medicine, University of Toronto, Toronto, ON, Canada, Division of General Internal Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, Division of Infectious Diseases, Sunnybrook Health Sciences Centre, Toronto, ON, Canada",[No abstract available],,"Canada; China; contact examination; coronavirus disease 2019; Coronavirus infection; coughing; fever; hemoptysis; human; hypertension; Note; patient isolation; polymerase chain reaction; priority journal; rhinorrhea; thorax radiography; throat culture; thrombocytopenia; travel; virus pneumonia; case report; communicable disease; complication; Coronavirinae; Coronavirus infection; fever; genetics; hemoptysis; male; middle aged; Ontario; severity of illness index; virus pneumonia; virus RNA; Canada; China; Communicable Diseases, Imported; Coronavirus; Coronavirus Infections; Fever; Hemoptysis; Humans; Male; Middle Aged; Ontario; Pneumonia, Viral; Polymerase Chain Reaction; Radiography, Thoracic; RNA, Viral; Severity of Illness Index",,"Leis, J.A.; Divisions of General Internal Medicine and Infectious Diseases, Sunnybrook Health Sciences CentreCanada; email: jerome.leis@sunnybrook.ca",,Lancet Publishing Group,1406736,,LANCA,32061312,English,Lancet,Note,Final,Open Access,Scopus,2-s2.0-85079904368,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wu J.T., Leung K., Leung G.M.",7409256423;57194749530;7007159841;,"Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study",2020,The Lancet,395,10225,,689,697,,62,10.1016/S0140-6736(20)30260-9,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078864717&doi=10.1016%2fS0140-6736%2820%2930260-9&partnerID=40&md5=0a3deda21971a6baa6d185965e4e33c5,"WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, Hong Kong","Wu, J.T., WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, Hong Kong; Leung, K., WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, Hong Kong; Leung, G.M., WHO Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, Hong Kong","Background: Since Dec 31, 2019, the Chinese city of Wuhan has reported an outbreak of atypical pneumonia caused by the 2019 novel coronavirus (2019-nCoV). Cases have been exported to other Chinese cities, as well as internationally, threatening to trigger a global outbreak. Here, we provide an estimate of the size of the epidemic in Wuhan on the basis of the number of cases exported from Wuhan to cities outside mainland China and forecast the extent of the domestic and global public health risks of epidemics, accounting for social and non-pharmaceutical prevention interventions. Methods: We used data from Dec 31, 2019, to Jan 28, 2020, on the number of cases exported from Wuhan internationally (known days of symptom onset from Dec 25, 2019, to Jan 19, 2020) to infer the number of infections in Wuhan from Dec 1, 2019, to Jan 25, 2020. Cases exported domestically were then estimated. We forecasted the national and global spread of 2019-nCoV, accounting for the effect of the metropolitan-wide quarantine of Wuhan and surrounding cities, which began Jan 23–24, 2020. We used data on monthly flight bookings from the Official Aviation Guide and data on human mobility across more than 300 prefecture-level cities in mainland China from the Tencent database. Data on confirmed cases were obtained from the reports published by the Chinese Center for Disease Control and Prevention. Serial interval estimates were based on previous studies of severe acute respiratory syndrome coronavirus (SARS-CoV). A susceptible-exposed-infectious-recovered metapopulation model was used to simulate the epidemics across all major cities in China. The basic reproductive number was estimated using Markov Chain Monte Carlo methods and presented using the resulting posterior mean and 95% credibile interval (CrI). Findings: In our baseline scenario, we estimated that the basic reproductive number for 2019-nCoV was 2·68 (95% CrI 2·47–2·86) and that 75 815 individuals (95% CrI 37 304–130 330) have been infected in Wuhan as of Jan 25, 2020. The epidemic doubling time was 6·4 days (95% CrI 5·8–7·1). We estimated that in the baseline scenario, Chongqing, Beijing, Shanghai, Guangzhou, and Shenzhen had imported 461 (95% CrI 227–805), 113 (57–193), 98 (49–168), 111 (56–191), and 80 (40–139) infections from Wuhan, respectively. If the transmissibility of 2019-nCoV were similar everywhere domestically and over time, we inferred that epidemics are already growing exponentially in multiple major cities of China with a lag time behind the Wuhan outbreak of about 1–2 weeks. Interpretation: Given that 2019-nCoV is no longer contained within Wuhan, other major Chinese cities are probably sustaining localised outbreaks. Large cities overseas with close transport links to China could also become outbreak epicentres, unless substantial public health interventions at both the population and personal levels are implemented immediately. Independent self-sustaining outbreaks in major cities globally could become inevitable because of substantial exportation of presymptomatic cases and in the absence of large-scale public health interventions. Preparedness plans and mitigation interventions should be readied for quick deployment globally. Funding: Health and Medical Research Fund (Hong Kong, China). © 2020 Elsevier Ltd",,Article; basic reproduction number; China; controlled study; Coronavirus infection; coronavirus infection 2019; disease transmission; epidemic; forecasting; human; incidence; incubation time; intervention study; Markov Chain Monte Carlo method; metapopulation; Monte Carlo method; nowcasting and forecasting; prevalence; priority journal; quarantine; severe acute respiratory syndrome; simulation; computer simulation; Coronavirus infection; epidemic; forecasting; hospitalization; international cooperation; Markov chain; China; Computer Simulation; Coronavirus Infections; Epidemics; Forecasting; Hospitalization; Humans; Infectious Disease Incubation Period; Internationality; Markov Chains; Monte Carlo Method; Prevalence,"Lloyd-Smith, J.O., Schreiber, S.J., Kopp, P.E., Getz, W.M., Superspreading and the effect of individual variation on disease emergence (2005) Nature, 438, pp. 355-359; Chowell, G., Castillo-Chavez, C., Fenimore, P.W., Kribs-Zaleta, C.M., Arriola, L., Hyman, J.M., Model parameters and outbreak control for SARS (2004) Emerg Infect Dis, 10, pp. 1258-1263; Riley, S., Fraser, C., Donnelly, C.A., Transmission dynamics of the etiological agent of SARS in Hong Kong: impact of public health interventions (2003) Science, 300, pp. 1961-1966; Lipsitch, M., Cohen, T., Cooper, B., Transmission dynamics and control of severe acute respiratory syndrome (2003) Science, 300, pp. 1966-1970; Chowell, G., Abdirizak, F., Lee, S., Transmission characteristics of MERS and SARS in the healthcare setting: a comparative study (2015) BMC Med, 13, p. 210; Kucharski, A.J., Althaus, C., The role of superspreading in Middle East respiratory syndrome coronavirus (MERS-CoV) transmission (2015) Euro Surveill, 20, pp. 14-18; Cauchemez, S., Nouvellet, P., Cori, A., Unraveling the drivers of MERS-CoV transmission (2016) Proc Natl Acad Sci USA, 113, pp. 9081-9086; Park, J.-E., Jung, S., Kim, A., Park, J.E., MERS transmission and risk factors: a systematic review (2018) BMC Public Health, 18, p. 574; Walsh, E.E., Shin, J.H., Falsey, A.R., Clinical impact of human coronaviruses 229E and OC43 infection in diverse adult populations (2013) J Infect Dis, 208, pp. 1634-1642; Zhang, S.F., Tuo, J.L., Huang, X.B., Epidemiology characteristics of human coronaviruses in patients with respiratory infection symptoms and phylogenetic analysis of HCoV-OC43 during 2010-2015 in Guangzhou (2018) PLoS One, 13, p. e0191789; Gaunt, E.R., Hardie, A., Claas, E.C., Simmonds, P., Templeton, K.E., Epidemiology and clinical presentations of the four human coronaviruses 229E, HKU1, NL63, and OC43 detected over 3 years using a novel multiplex real-time PCR method (2010) J Clin Microbiol, 48, pp. 2940-2947; Leung, G.M., Hedley, A.J., Ho, L.M., The epidemiology of severe acute respiratory syndrome in the 2003 Hong Kong epidemic: an analysis of all 1755 patients (2004) Ann Intern Med, 141, pp. 662-673; Lau, E.H., Hsiung, C.A., Cowling, B.J., A comparative epidemiologic analysis of SARS in Hong Kong, Beijing and Taiwan (2010) BMC Infect Dis, 10, p. 50; Virlogeux, V., Fang, V.J., Park, M., Wu, J.T., Cowling, B.J., Comparison of incubation period distribution of human infections with MERS-CoV in South Korea and Saudi Arabia (2016) Sci Rep, 6, p. 35839; Vijgen, L., Keyaerts, E., Moës, E., Complete genomic sequence of human coronavirus OC43: molecular clock analysis suggests a relatively recent zoonotic coronavirus transmission event (2005) J Virol, 79, pp. 1595-1604; Lessler, J., Reich, N.G., Brookmeyer, R., Perl, T.M., Nelson, K.E., Cummings, D.A., Incubation periods of acute respiratory viral infections: a systematic review (2009) Lancet Infect Dis, 9, pp. 291-300; Mason, R., Broaddus, V.C., Martin, T., (2010) Murray and Nadel's textbook of respiratory medicine, , 5th edn. Elsevier Amsterdam; Cowling, B.J., Park, M., Fang, V.J., Wu, P., Leung, G.M., Wu, J.T., Preliminary epidemiological assessment of MERS-CoV outbreak in South Korea, May to June 2015 (2015) Euro Surveill, 20, pp. 7-13; Leung, G.M., Lim, W.W., Ho, L.M., Seroprevalence of IgG antibodies to SARS-coronavirus in asymptomatic or subclinical population groups (2006) Epidemiol Infect, 134, pp. 211-221; Al Kahlout, R.A., Nasrallah, G.K., Farag, E.A., Comparative serological study for the prevalence of anti-MERS coronavirus antibodies in high-and low-risk groups in Qatar (2019) J Immunol Res, , published online Feb 18. DOI:; Abbad, A., Perera, R.A., Anga, L., Middle East respiratory syndrome coronavirus (MERS-CoV) neutralising antibodies in a high-risk human population, Morocco, November 2017 to January 2018 (2019) Euro Surveill, 24, p. 1900244; Gill, E.P., Dominguez, E.A., Greenberg, S.B., Development and application of an enzyme immunoassay for coronavirus OC43 antibody in acute respiratory illness (1994) J Clin Microbiol, 32, pp. 2372-2376; Chan, C.M., Tse, H., Wong, S.S., Examination of seroprevalence of coronavirus HKU1 infection with S protein-based ELISA and neutralization assay against viral spike pseudotyped virus (2009) J Clin Virol, 45, pp. 54-60; Oh, M.D., Park, W.B., Park, S.W., Middle East respiratory syndrome: what we learned from the 2015 outbreak in the Republic of Korea (2018) Korean J Intern Med, 33, pp. 233-246; Patrick, D.M., Petric, M., Skowronski, D.M., An outbreak of human coronavirus OC43 infection and serological cross-reactivity with SARS coronavirus (2006) Can J Infect Dis Med Microbiol, 17, pp. 330-336; Matsuno, A.K., Gagliardi, T.B., Paula, F.E., Human coronavirus alone or in co-infection with rhinovirus C is a risk factor for severe respiratory disease and admission to the pediatric intensive care unit: a one-year study in Southeast Brazil (2019) PLoS One, 14, p. e0217744; Jia, N., Feng, D., Fang, L.Q., Case fatality of SARS in mainland China and associated risk factors (2009) Trop Med Int Health, 14, pp. 21-27; Breban, R., Riou, J., Fontanet, A., Interhuman transmissibility of Middle East respiratory syndrome coronavirus: estimation of pandemic risk (2013) Lancet, 382, pp. 694-699; Cauchemez, S., Fraser, C., Van Kerkhove, M.D., Middle East respiratory syndrome coronavirus: quantification of the extent of the epidemic, surveillance biases, and transmissibility (2014) Lancet Infect Dis, 14, pp. 50-56; Hung, L.S., The SARS epidemic in Hong Kong: what lessons have we learned? (2003) J R Soc Med, 96, pp. 374-378; McDonald, L.C., Simor, A.E., Su, I.J., SARS in healthcare facilities, Toronto and Taiwan (2004) Emerg Infect Dis, 10, pp. 777-781; Wuhan is expected to send 15 million passengers during Spring Festival in 2020 (in Chinese) (2019), http://hb.people.com.cn/n2/2019/1228/c194063-33671662.html, (Accessed 2 January 2020); Li, Q., An outbreak of NCIP (2019-nCoV) infection in China—Wuhan, Hubei Province, 2019–2020 (2020) China CDC Weekly, 2, pp. 79-80; Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med, , published online Jan 29. DOI:; Wang, L., Wu, J.T., Characterizing the dynamics underlying global spread of epidemics (2018) Nat Commun, 9, p. 218; Bootsma, M.C., Ferguson, N.M., The effect of public health measures on the 1918 influenza pandemic in U.S. cities (2007) Proc Natl Acad Sci USA, 104, pp. 7588-7593; Frequently asked questions about SARS (2005), https://www.cdc.gov/sars/about/faq.html, (Accessed 25 January 2020); Diekmann, O., Heesterbeek, J.A.P., (2000) Mathematical epidemiology of infectious diseases: model building, analysis and interpretation, , John Wiley Chichester; Desai, A.N., Kraemer, M.U.G., Bhatia, S., Real-time epidemic forecasting: challenges and opportunities (2019) Health Secur, 17, pp. 268-275; Polonsky, J.A., Baidjoe, A., Kamvar, Z.N., Outbreak analytics: a developing data science for informing the response to emerging pathogens (2019) Philos Trans R Soc Lond B Biol Sci, 374, p. 20180276; Lipsitch, M., Finelli, L., Heffernan, R.T., Leung, G.M., Redd, S.C., Improving the evidence base for decision making during a pandemic: the example of 2009 influenza A/H1N1 (2011) Biosecur Bioterror, 9, pp. 89-115; Imai, N., Cori, A., Dorigatti, I., MRC Centre for Global Infectious Disease Analysis: Wuhan coronavirus reports 1–3 (2020), https://www.imperial.ac.uk/mrc-global-infectious-disease-analysis/news–wuhan-coronavirus, (Accessed 25 January 2020); Read, J.M., Bridgen, J.R.E., Cummings, D.A.T., Ho, A., Jewell, C.P., Novel coronavirus 2019-nCoV: early estimation of epidemiological parameters and epidemic predictions (2020) medRxiv, , published online Jan 24. DOI: (preprint); Liu, T., Hu, J., Kang, M., Transmission dynamics of 2019 novel coronavirus (2019-nCoV) (2020) bioRxiv, , published online Jan 26. DOI: (preprint); Zhao, S., Ran, J., Musa, S.S., Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: a data-driven analysis in the early phase of the outbreak (2020) bioRxiv, , published online Jan 24. DOI: (preprint); Announcement of the State Administration of Market Supervision, Ministry of Agriculture and Rural Affairs, and the National Forestry and Grass Bureau on banning wildlife trading (in Chinese) (2020), http://gkml.samr.gov.cn/nsjg/wjs/202001/t20200126_310742.html, (Accessed 25 January 2020)","Wu, J.T.; School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong KongHong Kong; email: joewu@hku.hk",,Lancet Publishing Group,1406736,,LANCA,32014114,English,Lancet,Article,Final,Open Access,Scopus,2-s2.0-85078864717,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Shanmugaraj B., Siriwattananon K., Wangkanont K., Phoolcharoen W.",55382181000;57211469356;26656443700;26531746600;,Perspectives on monoclonal antibody therapy as potential therapeutic intervention for Coronavirus disease-19 (COVID-19),2020,Asian Pacific journal of allergy and immunology,38,1,,10,18,,,10.12932/AP-200220-0773,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082146092&doi=10.12932%2fAP-200220-0773&partnerID=40&md5=e00cba68313449a86d9e36757544da5e,"Research unit for Plant-produced Pharmaceuticals, Chulalongkorn UniversityBangkok, Thailand; Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn UniversityBangkok, Thailand; Department of Biochemistry, Faculty of Science, Chulalongkorn UniversityBangkok, Thailand","Shanmugaraj, B., Research unit for Plant-produced Pharmaceuticals, Chulalongkorn UniversityBangkok, Thailand, Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn UniversityBangkok, Thailand; Siriwattananon, K., Research unit for Plant-produced Pharmaceuticals, Chulalongkorn UniversityBangkok, Thailand, Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn UniversityBangkok, Thailand; Wangkanont, K., Department of Biochemistry, Faculty of Science, Chulalongkorn UniversityBangkok, Thailand; Phoolcharoen, W., Research unit for Plant-produced Pharmaceuticals, Chulalongkorn UniversityBangkok, Thailand, Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn UniversityBangkok, Thailand","Last decade witnessed the outbreak of many life-threatening human pathogens including Nipah, Ebola, Chikungunya, Zika, Middle East respiratory syndrome coronavirus (MERS-CoV), Severe Acute respiratory syndrome coronavirus (SARS-CoV) and more recently novel coronavirus (2019-nCoV or SARS-CoV-2). The disease condition associated with novel coronavirus, referred to as Coronavirus disease (COVID-19). The emergence of novel coronavirus in 2019 in Wuhan, China marked the third highly pathogenic coronavirus infecting humans in the 21st century. The continuing emergence of coronaviruses at regular intervals poses a significant threat to human health and economy. Ironically, even after a decade of research on coronavirus, still there are no licensed vaccines or therapeutic agents to treat coronavirus infection which highlights an urgent need to develop effective vaccines or post-exposure prophylaxis to prevent future epidemics. Several clinical, genetic and epidemiological features of COVID-19 resemble SARS-CoV infection. Hence, the research advancements on SARS-CoV treatment might help scientific community in quick understanding of this virus pathogenesis and develop effective therapeutic/prophylactic agents to treat and prevent this infection. Monoclonal antibodies represent the major class of biotherapeutics for passive immunotherapy to fight against viral infection. The therapeutic potential of monoclonal antibodies has been well recognized in the treatment of many diseases. Here, we summarize the potential monoclonal antibody based therapeutic intervention for COVID-19 by considering the existing knowledge on the neutralizing monoclonal antibodies against similar coronaviruses SARS-CoV and MERS-CoV. Further research on COVID-19 pathogenesis could identify appropriate therapeutic targets to develop specific anti-virals against this newly emerging pathogen.",,"coronavirus spike glycoprotein; COVID-19; monoclonal antibody; neutralizing antibody; severe acute respiratory syndrome coronavirus 2; spike glycoprotein, COVID-19 virus; virus antibody; virus receptor; Betacoronavirus; binding site; chemistry; China; Coronavirus infection; human; immunotherapy; Middle East respiratory syndrome coronavirus; protein tertiary structure; SARS coronavirus; virus pneumonia; Antibodies, Monoclonal; Antibodies, Neutralizing; Antibodies, Viral; Betacoronavirus; Binding Sites; China; Coronavirus Infections; Humans; Immunotherapy; Middle East Respiratory Syndrome Coronavirus; Pneumonia, Viral; Protein Structure, Tertiary; Receptors, Virus; SARS Virus; Spike Glycoprotein, Coronavirus",,,,NLM (Medline),0125877X,,,32134278,English,Asian Pac. J. Allergy Immunol.,Review,Final,Open Access,Scopus,2-s2.0-85082146092,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Shankar A., Saini D., Roy S., Jarrahi A.M., Chakraborty A., Bharati S.J., Taghizadeh-Hesary F.",56644191400;57209255940;56643589200;57216081492;57194504037;36996380200;57204594196;,Cancer care delivery challenges amidst coronavirus disease -19 (covid-19) outbreak: Specific precautions for cancer patients and cancer care providers to prevent spread,2020,Asian Pacific Journal of Cancer Prevention,21,3,,569,573,,,10.31557/APJCP.2020.21.3.569,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082522877&doi=10.31557%2fAPJCP.2020.21.3.569&partnerID=40&md5=45adbf0af88530adfb334bb9adfa5a82,"Department of Radiation Oncology, Lady Hardinge Medical College, Director General Health Services, Ministry of Health and Family Welfare, India; Indian Society of Clinical Oncology, Department of Oncoanaesthesia and oPalliative Medicine, Dr BR Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, Delhi, India; Sitaram Bhartia Institute of Science and Research, Department of Oncoanaesthesia and oPalliative Medicine, Dr BR Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, Delhi, India; Department of Social Medicine, Medical School, Department of Radiation Oncology, Shaheed Beheshti University of medical Sciences, Tehran, Iran; Baylor College of Medicine, Houston, United States; Department of Oncoanaesthesia and oPalliative Medicine, Dr BR Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, Delhi, India; Department of Radiation Oncology, Shaheed Beheshti University of medical Sciences, Tehran, Iran","Shankar, A., Department of Radiation Oncology, Lady Hardinge Medical College, Director General Health Services, Ministry of Health and Family Welfare, India; Saini, D., Indian Society of Clinical Oncology, Department of Oncoanaesthesia and oPalliative Medicine, Dr BR Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, Delhi, India; Roy, S., Sitaram Bhartia Institute of Science and Research, Department of Oncoanaesthesia and oPalliative Medicine, Dr BR Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, Delhi, India; Jarrahi, A.M., Department of Social Medicine, Medical School, Department of Radiation Oncology, Shaheed Beheshti University of medical Sciences, Tehran, Iran; Chakraborty, A., Baylor College of Medicine, Houston, United States; Bharati, S.J., Department of Oncoanaesthesia and oPalliative Medicine, Dr BR Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, Delhi, India; Taghizadeh-Hesary, F., Department of Radiation Oncology, Shaheed Beheshti University of medical Sciences, Tehran, Iran","Coronavirus outbreak has affected thousands of people in at least 186 countries which has affected the cancer care delivery system apart from affecting the overall health system. Cancer patients are more susceptible to coronavirus infection than individuals without cancer as they are in an immunosuppressive state because of the malignancy and anticancer treatment. Oncologists should be more attentive to detect coronavirus infection early, as any type of advanced cancer is at much higher risk for unfavorable outcomes. Oncology communities must ensure that cancer patients should spend more time at home and less time out in the community. Oncologists and other health care professionals involved in cancer care have a critical opportunity to communicate to their patients to pass on right information regarding practice modifications in view of COVID-19 outbreaks. Countries must isolate, test, treat and trace to control the coronavirus pandemic. There is a paucity of information on novel coronavirus infection and its impact on cancer patients and cancer care providers. To date, there is no scientific guideline regarding management of cancer patients in a background of coronavirus outbreak. © 2020, Asian Pacific Organization for Cancer Prevention.",Cancer; Coronavirus; COVID-19; Patients,,"Cai, Q., Huang, D., Ou, P., COVID-19 in a Designated Infectious Diseases Hospital Outside Hubei Province,China (2020) Preprint. Posted online February, 19, p. 2020. , medRxiv 20024018; Coronavirus disease 2019 (COVID-19) situation summary https://www.cdc.gov/coronavirus/2019-ncov/cases-updates/summary,html?CDC_AA_refVal=https%3A%2F%2Fwww.cdc.gov%2Fcoronavirus%2F2019-ncov%2Fsummary.html; Revised Strategy of COVID19 testing in India https://www.mohfw.gov.in/pdf/ICMRrevisedtestingstrategyforCOVID.pdf; SARS-CoV-2(COVID-19)Testing: Status Update https://icmr.nic.in/sites/default/files/whats_new/ICMR_website_update_22March_6PM_IST.pdf; Liang, W., Guan, W., Chen, R., Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China (2020) Lancet Oncol, 21, pp. 335-337; Coronavirus disease (COVID-19) advice for the public: Myth busters (2020), https://www.who.int/emergencies/diseases/novelcoronavirus-2019/advice-for-public/myth-busters; Novel coronavirus -China https://www.who.int/csr/don/12-january-2020-novel-coronavirus-china/en/; Key considerations for repatriation and quarantine of travellers in relation to outbreak of novel coronavirus 2019-nCoV https://www.who.int/ith/Repatriation_Quarantine_nCoV-key-considerations_HQ-final11Feb.pdf?ua=1&fbclid=IwAR3wzl3VKjd-dVscDNpoQb5hEy-NdRafaaQqicHSgrvKQ6B5y0HADU3ZQAA; Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19) https://www.who.int/publications-detail/report-of-the-who-china-joint-missionon-coronavirus-disease-2019-(covid-19); WHO Director-General's opening remarks at the media briefing on COVID-19 https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-atthe-media-briefing-on-covid-19---18-march-2020; Infection prevention and control during health care when COVID-19 is suspected https://www.who.int/publications-detail/infection-prevention-and-control-duringhealth-care-when-novel-coronavirus-(ncov)-infection-issuspected-20200125; Novel Coronavirus (COVID-19) Situation https://experience.arcgis.com/experience/685d0ace521648f8a5beeeee1b9125cd; Yu, J., Ouyang, W., Chua, M.L.K., SARS-CoV-2 transmission in cancer patients of a tertiary hospital in Wuhan (2020) Preprint. Posted online February, 25, p. 2020. , medRxiv 20025320; Zhao, S., Lin, Q., Ran, J., Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: A data-driven analysis in the early phase of the outbreak (2020) Int J Infect Dis,, 92, pp. 214-217; Zhou, F., Yu, T., Du, R., Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study (2020) Lancet, online, 2020. , https://doi.org/10.1016/S0140-6736(20)30566-3, March 11","Shankar, A.; Department of Radiation Oncology, Lady Hardinge Medical College, Director General Health Services, Ministry of Health and Family WelfareIndia; email: doc.abhishankar@gmail.com",,Asian Pacific Organization for Cancer Prevention,15137368,,,32212779,English,Asian Pac. J. Cancer Preven.,Article,Final,Open Access,Scopus,2-s2.0-85082522877,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Rabi F.A., Al Zoubi M.S., Al-Nasser A.D., Kasasbeh G.A., Salameh D.M.",57215862499;55312658600;8450540200;57215857202;57215860822;,Sars-cov-2 and coronavirus disease 2019: What we know so far,2020,Pathogens,9,3,231,,,,,10.3390/pathogens9030231,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082112664&doi=10.3390%2fpathogens9030231&partnerID=40&md5=79cda7265021485bba57ac92ee27a1b1,"Department of Clinical Sciences, Faculty of Medicine, Yarmouk University, Irbid, 21163, Jordan; Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, 21163, Jordan; School of Medicine, Yarmouk University, Irbid, 21163, Jordan; Department of Statistics, Faculty of Sciences, Yarmouk University, Irbid, 21163, Jordan","Rabi, F.A., Department of Clinical Sciences, Faculty of Medicine, Yarmouk University, Irbid, 21163, Jordan; Al Zoubi, M.S., Department of Basic Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, 21163, Jordan; Al-Nasser, A.D., Department of Statistics, Faculty of Sciences, Yarmouk University, Irbid, 21163, Jordan; Kasasbeh, G.A., School of Medicine, Yarmouk University, Irbid, 21163, Jordan; Salameh, D.M., School of Medicine, Yarmouk University, Irbid, 21163, Jordan","In December 2019, a cluster of fatal pneumonia cases presented in Wuhan, China. They were caused by a previously unknown coronavirus. All patients had been associated with the Wuhan Wholefood market, where seafood and live animals are sold. The virus spread rapidly and public health authorities in China initiated a containment effort. However, by that time, travelers had carried the virus to many countries, sparking memories of the previous coronavirus epidemics, severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), and causing widespread media attention and panic. Based on clinical criteria and available serological and molecular information, the new disease was called coronavirus disease of 2019 (COVID-19), and the novel coronavirus was called SARS Coronavirus-2 (SARS-CoV-2), emphasizing its close relationship to the 2002 SARS virus (SARS-CoV). The scientific community raced to uncover the origin of the virus, understand the pathogenesis of the disease, develop treatment options, define the risk factors, and work on vaccine development. Here we present a summary of current knowledge regarding the novel coronavirus and the disease it causes. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.",Coronavirus; COVID-19; Pandemic; SARS; SARS-CoV-2; Wuhan,angiotensin converting enzyme 1; CD4 antigen; CD8 antigen; chloroquine; dipeptidyl carboxypeptidase; messenger RNA; remdesivir; unclassified drug; 2019 novel coronavirus; antigen presenting cell; case fatality rate; cell infection; clinical assessment; contagiousness; Coronavirinae; coronavirus disease 2019; disease transmission; gene mutation; gene sequence; human; immunopathology; incubation temperature; inflammation; Metapneumovirus; mortality rate; nonhuman; pathogenesis; Pholidota (animal); polymerase chain reaction; Review; risk factor; SARS coronavirus; sequence analysis; Th1 cell; vaccination; viral load testing,"(2011), https://talk.ictvonline.org/ictv-reports/ictv_9th_report/positive-sense-rna-viruses-2011/w/posrna_viruses/222/coronaviridae, Coronaviridae—Positive Sense RNA Viruses—Positive Sense RNA Viruses; Cui, J., Li, F., Shi, Z.-L., Origin and evolution of pathogenic coronaviruses (2019) Nat. 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Biol., 22, pp. 113-128; (2020) Safety and Immunogenicity Study of 2019-Ncov Vaccine (Mrna-1273) to Treat Novel Coronavirus—Full Text View—ClinicalTrials.gov, , https://clinicaltrials.gov/ct2/show/NCT04283461","Rabi, F.A.; Department of Clinical Sciences, Faculty of Medicine, Yarmouk UniversityJordan; email: firas.rabi@yu.edu.jo",,MDPI AG,20760817,,,,English,Pathogens,Review,Final,Open Access,Scopus,2-s2.0-85082112664,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Kampf G., Todt D., Pfaender S., Steinmann E.",7006532332;56136972100;55320564800;57205307744;,Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents,2020,Journal of Hospital Infection,104,3,,246,251,,9,10.1016/j.jhin.2020.01.022,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079891308&doi=10.1016%2fj.jhin.2020.01.022&partnerID=40&md5=bd94ddc4fad97d68f09eaa2eed534ac8,"University Medicine Greifswald, Institute for Hygiene and Environmental Medicine, Ferdinand-Sauerbruch-Straße, Greifswald, 17475, Germany; Department of Molecular and Medical Virology, Ruhr University Bochum, Universitätsstrasse 50, Bochum, 44801, Germany","Kampf, G., University Medicine Greifswald, Institute for Hygiene and Environmental Medicine, Ferdinand-Sauerbruch-Straße, Greifswald, 17475, Germany; Todt, D., Department of Molecular and Medical Virology, Ruhr University Bochum, Universitätsstrasse 50, Bochum, 44801, Germany; Pfaender, S., Department of Molecular and Medical Virology, Ruhr University Bochum, Universitätsstrasse 50, Bochum, 44801, Germany; Steinmann, E., Department of Molecular and Medical Virology, Ruhr University Bochum, Universitätsstrasse 50, Bochum, 44801, Germany","Currently, the emergence of a novel human coronavirus, SARS-CoV-2, has become a global health concern causing severe respiratory tract infections in humans. Human-to-human transmissions have been described with incubation times between 2-10 days, facilitating its spread via droplets, contaminated hands or surfaces. We therefore reviewed the literature on all available information about the persistence of human and veterinary coronaviruses on inanimate surfaces as well as inactivation strategies with biocidal agents used for chemical disinfection, e.g. in healthcare facilities. The analysis of 22 studies reveals that human coronaviruses such as Severe Acute Respiratory Syndrome (SARS) coronavirus, Middle East Respiratory Syndrome (MERS) coronavirus or endemic human coronaviruses (HCoV) can persist on inanimate surfaces like metal, glass or plastic for up to 9 days, but can be efficiently inactivated by surface disinfection procedures with 62–71% ethanol, 0.5% hydrogen peroxide or 0.1% sodium hypochlorite within 1 minute. Other biocidal agents such as 0.05–0.2% benzalkonium chloride or 0.02% chlorhexidine digluconate are less effective. As no specific therapies are available for SARS-CoV-2, early containment and prevention of further spread will be crucial to stop the ongoing outbreak and to control this novel infectious thread. © 2020 The Healthcare Infection Society",Biocidal agents; Chemical inactivation; Coronavirus; Disinfection; Inanimate surfaces; Persistence,"alcohol; benzalkonium chloride; biocide; chlorhexidine gluconate; glass; hydrogen peroxide; hypochlorite sodium; metal; plastic; COVID-19; disinfectant agent; severe acute respiratory syndrome coronavirus 2; 2019 novel coronavirus; Canine coronavirus; clinical effectiveness; Coronavirinae; disinfection; health care facility; hepatitis virus; human; Middle East respiratory syndrome coronavirus; nonhuman; Review; surface area; Transmissible gastroenteritis virus; virus inactivation; virus transmission; Betacoronavirus; Coronavirus infection; drug effect; environmental microbiology; growth, development and aging; microbial viability; virus pneumonia; Betacoronavirus; Coronavirus Infections; Disinfectants; Environmental Microbiology; Humans; Microbial Viability; Pneumonia, Viral","WHO, Coronavirus Disease 2019 (COVID-19) (2020), WHO Situation Report 23; de Wit, E., van Doremalen, N., Falzarano, D., Munster, V.J., SARS and MERS: recent insights into emerging coronaviruses (2016) Nat Rev Microbiol, 14, pp. 523-534; Chan, J.F., Yuan, S., Kok, K.H., To, K.K., Chu, H., Yang, J., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet; Otter, J.A., Donskey, C., Yezli, S., Douthwaite, S., Goldenberg, S.D., Weber, D.J., Transmission of SARS and MERS coronaviruses and influenza virus in healthcare settings: the possible role of dry surface contamination (2016) J Hosp Infect, 92, pp. 235-250; Dowell, S.F., Simmerman, J.M., Erdman, D.D., Wu, J.S., Chaovavanich, A., Javadi, M., Severe acute respiratory syndrome coronavirus on hospital surfaces (2004) Clin Infect Dis, 39, pp. 652-657; Geller, C., Varbanov, M., Duval, R.E., Human coronaviruses: insights into environmental resistance and its influence on the development of new antiseptic strategies (2012) Viruses, 4, pp. 3044-3068; Kampf, G., Antiseptic stewardship: biocide resistance and clinical implications (2018), Springer International Publishing Cham; Ijaz, M.K., Brunner, A.H., Sattar, S.A., Nair, R.C., Johnson-Lussenburg, C.M., Survival characteristics of airborne human coronavirus 229E (1985) J Gen Virol, 66, pp. 2743-2748; Bean, B., Moore, B.M., Sterner, B., Peterson, L.R., Gerding, D.N., Balfour, H.H., Survival of influenza viruses an environmental surfaces (1982) J Infect Dis, 146, pp. 47-51; Ansari, S.A., Springthorpe, V.S., Sattar, S.A., Rivard, S., Rahman, M., Potential role of hands in the spread of respiratory viral infections: studies with human parainfluenza virus 3 and rhinovirus 14 (1991) J Clin Microbiol, 29, pp. 2115-2119; Kwok, Y.L., Gralton, J., McLaws, M.L., Face touching: a frequent habit that has implications for hand hygiene (2015) Am J Infect Contr, 43, pp. 112-114; WHO, Infection prevention and control during health care when novel coronavirus (nCoV) infection is suspected (2020), WHO Interim guidance. 25 January 2020; WHO. 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Wong, T.W., Tam, W.W., Handwashing practice and the use of personal protective equipment among medical students after the SARS epidemic in Hong Kong (2005) Am J Infect Contr, 33, pp. 580-586; Wiboonchutikul, S., Manosuthi, W., Likanonsakul, S., Sangsajja, C., Kongsanan, P., Nitiyanontakij, R., Lack of transmission among healthcare workers in contact with a case of Middle East respiratory syndrome coronavirus infection in Thailand (2016) Antimicrob Resist Infect Control, 5, p. 21; Ki, H.K., Han, S.K., Son, J.S., Park, S.O., Risk of transmission via medical employees and importance of routine infection-prevention policy in a nosocomial outbreak of Middle East respiratory syndrome (MERS): a descriptive analysis from a tertiary care hospital in South Korea (2019) BMC Pulm Med, 19, p. 190; van Doremalen, N., Bushmaker, T., Munster, V.J., Stability of Middle East respiratory syndrome coronavirus (MERS-CoV) under different environmental conditions (2013) Euro Surveill, 18; Casanova, L.M., Jeon, S., Rutala, W.A., Weber, D.J., Sobsey, M.D., Effects of air temperature and relative humidity on coronavirus survival on surfaces (2010) Appl Environ Microbiol, 76, pp. 2712-2717; Warnes, S.L., Little, Z.R., Keevil, C.W., Human Coronavirus 229E Remains Infectious on Common Touch Surface Materials (2015) mBio, 6, pp. e01697-15; Sizun, J., Yu, M.W., Talbot, P.J., Survival of human coronaviruses 229E and OC43 in suspension and after drying on surfaces: a possible source of hospital-acquired infections (2000) J Hosp Infect, 46, pp. 55-60; Duan, S.M., Zhao, X.S., Wen, R.F., Huang, J.J., Pi, G.H., Zhang, S.X., Stability of SARS coronavirus in human specimens and environment and its sensitivity to heating and UV irradiation (2003) Biomed Environ Sci, 16, pp. 246-255; Lai, M.Y., Cheng, P.K., Lim, W.W., Survival of severe acute respiratory syndrome coronavirus (2005) Clin Infect Dis, 41, pp. e67-e71; Chan, K.H., Peiris, J.S., Lam, S.Y., Poon, L.L., Yuen, K.Y., Seto, W.H., The Effects of Temperature and Relative Humidity on the Viability of the SARS Coronavirus (2011) Adv Virol, p. 734690; Rabenau, H.F., Cinatl, J., Morgenstern, B., Bauer, G., Preiser, W., Doerr, H.W., Stability and inactivation of SARS coronavirus (2005) Med Microbiol Immunol, 194, pp. 1-6; Rabenau, H.F., Kampf, G., Cinatl, J., Doerr, H.W., Efficacy of various disinfectants against SARS coronavirus (2005) J Hosp Infect, 61, pp. 107-111; Saknimit, M., Inatsuki, I., Sugiyama, Y., Yagami, K., Virucidal efficacy of physico-chemical treatments against coronaviruses and parvoviruses of laboratory animals (1988) Jikken Dobutsu Exp Anim, 37, pp. 341-345; Wood, A., Payne, D., The action of three antiseptics/disinfectants against enveloped and non-enveloped viruses (1998) J Hosp Infect, 38, pp. 283-295; Pratelli, A., Action of disinfectants on canine coronavirus replication in vitro (2007) Zoonoses Publ Health, 54, pp. 383-386; Dellanno, C., Vega, Q., Boesenberg, D., The antiviral action of common household disinfectants and antiseptics against murine hepatitis virus, a potential surrogate for SARS coronavirus (2009) Am J Infect Control, 37, pp. 649-652; Omidbakhsh, N., Sattar, S.A., Broad-spectrum microbicidal activity, toxicologic assessment, and materials compatibility of a new generation of accelerated hydrogen peroxide-based environmental surface disinfectant (2006) Am J Infect Control, 34, pp. 251-257; Pratelli, A., Canine coronavirus inactivation with physical and chemical agents (2008) Vet J (London, England : 1997), 177, pp. 71-79; Kariwa, H., Fujii, N., Takashima, I., Inactivation of SARS coronavirus by means of povidone-iodine, physical conditions and chemical reagents (2006) Dermatol (Basel, Switzerland), 212, pp. 119-123; Eggers, M., Eickmann, M., Zorn, J., Rapid and Effective Virucidal Activity of Povidone-Iodine Products Against Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and Modified Vaccinia Virus Ankara (MVA) (2015) Infect Dis Ther, 4, pp. 491-501; Eggers, M., Koburger-Janssen, T., Eickmann, M., Zorn, J., In Vitro Bactericidal and Virucidal Efficacy of Povidone-Iodine Gargle/Mouthwash Against Respiratory and Oral Tract Pathogens (2018) Infect Dis Ther, 7, pp. 249-259; Hulkower, R.L., Casanova, L.M., Rutala, W.A., Weber, D.J., Sobsey, M.D., Inactivation of surrogate coronaviruses on hard surfaces by health care germicides (2011) Am J Infect Control, 39, pp. 401-407; Sattar, S.A., Springthorpe, V.S., Karim, Y., Loro, P., Chemical disinfection of non-porous inanimate surfaces experimentally contaminated with four human pathogenic viruses (1989) Epidemiol Infect, 102, pp. 493-505; Goyal, S.M., Chander, Y., Yezli, S., Otter, J.A., Evaluating the virucidal efficacy of hydrogen peroxide vapour (2014) J Hosp Infect, 86, pp. 255-259","Kampf, G.; University Medicine Greifswald, Institute for Hygiene and Environmental Medicine, Ferdinand-Sauerbruch-Straße, Germany; email: guenter.kampf@uni-greifswald.de",,W.B. Saunders Ltd,1956701,,JHIND,32035997,English,J. Hosp. Infect.,Review,Final,Open Access,Scopus,2-s2.0-85079891308,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Cheng S.-C., Chang Y.-C., Fan Chiang Y.-L., Chien Y.-C., Cheng M., Yang C.-H., Huang C.-H., Hsu Y.-N.",57215200737;57215197717;57215184642;57215184729;57215184023;57211135974;57215208879;57215208804;,First case of Coronavirus Disease 2019 (COVID-19) pneumonia in Taiwan,2020,Journal of the Formosan Medical Association,119,3,,747,751,,2,10.1016/j.jfma.2020.02.007,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080089938&doi=10.1016%2fj.jfma.2020.02.007&partnerID=40&md5=64f0c72ac85183c0340e46eefc96ce34,"Division of Pulmonary Medicine, Department of Internal Medicine, Sinwu Branch, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan; Department of Radiology, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan; Department of Internal Medicine, Sinwu Branch, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan; Department of Orthopedic Surgery, Sinwu Branch, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan; Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan; Department of Biomedical Engineering and Environmental Science, National Tsing Hua University, Hsinchu, Taiwan; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Sinwu Branch, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan; Department of Family Medicine, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan","Cheng, S.-C., Division of Pulmonary Medicine, Department of Internal Medicine, Sinwu Branch, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan; Chang, Y.-C., Department of Radiology, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan; Fan Chiang, Y.-L., Department of Internal Medicine, Sinwu Branch, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan; Chien, Y.-C., Department of Radiology, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan; Cheng, M., Department of Orthopedic Surgery, Sinwu Branch, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan; Yang, C.-H., Department of Radiology, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan, Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan, Department of Biomedical Engineering and Environmental Science, National Tsing Hua University, Hsinchu, Taiwan; Huang, C.-H., Division of Gastroenterology and Hepatology, Department of Internal Medicine, Sinwu Branch, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan; Hsu, Y.-N., Department of Family Medicine, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan","An outbreak of respiratory illness proved to be infected by a 2019 novel coronavirus, officially named Coronavirus Disease 2019 (COVID-19), was notified first in Wuhan, China, and has spread rapidly in China and to other parts of the world. Herein, we reported the first confirmed case of novel coronavirus pneumonia (NCP) imported from China in Taiwan. This case report revealed a natural course of NCP with self-recovery, which may be a good example in comparison with medical treatments. © 2020",COVID-19; First case; Pneumonia; Taiwan,"alanine aminotransferase; amoxicillin plus clavulanic acid; antitussive agent; aspartate aminotransferase; C reactive protein; ceftriaxone; lactate dehydrogenase; COVID-19; severe acute respiratory syndrome coronavirus 2; abnormal respiratory sound; adult; antibiotic therapy; Article; blood pressure; body temperature; breathing rate; case report; China; clinical article; comparative study; computer assisted tomography; Coronavirus infection; coughing; dyspnea; fatigue; female; fever; follow up; hospital admission; hospital discharge; human; hypothyroidism; laboratory test; lymphocytopenia; medical history; middle aged; oxygen saturation; physical examination; pneumonia; quarantine; real time reverse transcription polymerase chain reaction; SARS coronavirus; sore throat; Streptococcus gallolyticus; Taiwan; urinalysis; urine culture; Betacoronavirus; Coronavirus infection; isolation and purification; virology; virus pneumonia; watchful waiting; Betacoronavirus; Coronavirus Infections; Female; Humans; Middle Aged; Pneumonia, Viral; Taiwan; Watchful Waiting","World Health Organization, Novel coronavirus situation report -28 (2020), https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200217-sitrep-22-ncov.pdf?sfvrsn=fb6d49b1_2, World Health Organization Geneva, Switzerland (Accessed 18 February 2020); Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, S0140–6736 (20), pp. 30183-30185; Holshue, M.L., DeBolt, C., Lindquist, S., Lofy, K.H., Wiesman, J., Bruce, H., First case of 2019 novel coronavirus in the United States (2020) N Englera J Med, pp. 1-9. , [Epub ahead of print]; Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) J Am Med Assoc, pp. E1-E9. , [Epub ahead of print]; Arabi, Y.M., Alothman, A., Balkhy, H.H., Al-Dawood, A., AlJohani, S., Al Harbi, S., Treatment of Middle East respiratory syndrome with a combination of lopinavir-ritonavir and interferon-beta1b (MIRACLE trial): study protocol for a randomized controlled trial (2018) Trials, 19, pp. 81-93; Song, J.Y., Cheong, H.J., Heo, J.Y., Noh, J.Y., Yong, H.S., Kim, Y.K., Clinical, laboratory and radiologic characteristics of 2009 pandemic influenza A/H1N1 pneumonia: primary influenza pneumonia versus concomitant/secondary bacterial pneumonia (2011) Influenza Other Respir Viruses, 5, pp. e535-e543; Zhou, F., Li, H., Gu, L., Liu, M., Xue, C.X., Cao, B., Risk factors for nosocomial infection among hospitalised severe influenza A(H1N1) pandemic 2009 patients (2018) Respir Med, 134, pp. 86-91; Leung, G.M., Hedley, A.J., Ho, L.M., Chau, P., Wong, I.O., Thach, T.Q., The epidemiology of severe acute respiratory syndrome in the 2003 Hong Kong epidemic: an analysis of all 1755 patients (2004) Ann Intern Med, 141, pp. 662-673; Song, F., Shi, N., Shan, F., Zhang, Z., Shen, J., Lu, H., Emerging coronavirus 2019-nCoV pneumonia (2020) Radiology, p. 200274. , https://doi: 10.1148/radiol.2020200274, (Accessed 15 February 2020); Chung, M., Bernheim, A., Mei, X., Zhang, N., Huang, M., Zeng, X., CT imaging features of 2019 novel coronavirus (2019-nCoV) (2020) Radiology, p. 200230. , https://doi: 10.1148/radiol.2020200230, (Accessed 15 February 2020); Lei, J., Li, J., Li, X., Qi, X., CT Imaging of the 2019 novel coronavirus (2019-nCoV) pneumonia (2020) Radiology, p. 200236. , https://doi: 10.1148/radiol.2020200236, (Accessed 15 February 2020); Liu, P., Tan, X.Z., 2019 novel coronavirus (2019-nCoV) pneumonia (2020) Radiology, p. 200257. , https://doi: 10.1148/radiol.2020200257, (Accessed 15 February 2020); Fang, Y., Zhang, H., Xu, Y., Xie, J., Pang, P., Ji, W., CT manifestations of two cases of 2019 novel coronavirus (2019-nCoV) pneumonia (2020) Radiology, p. 200280. , https://doi: 10.1148/radiol.2020200280, (Accessed 15 February 2020); Chang, Y.C., Yu, C.J., Chang, S.C., Galvin, J.R., Liu, H.M., Hsiao, C.H., Pulmonary sequelae in convalescent patients after severe acute respiratory syndrome: evaluation with thin-section CT (2005) Radiology, 236, pp. 1067-1075; Pan, Y., Guan, H., Imaging changes in patients with 2019-nCov (2020) Eur Radiol, , (Accessed 15 February 2020); Shi, H., Han, X., Zheng, C., Evolution of CT manifestations in a patient recovered from 2019 novel coronavirus (2019-nCoV) pneumonia in Wuhan, China (2020) Radiology, p. 200269. , https://doi: 10.1148/radiol.2020200269, (Accessed 15 February 2020)","Huang, C.-H.; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Sinwu Branch, Taoyuan General Hospital, Ministry of Health and WelfareTaiwan; email: 4719@mail.tygh.gov.tw",,Elsevier B.V.,9296646,,JFASE,32113824,English,J. Formos. Med. Assoc.,Article,Final,Open Access,Scopus,2-s2.0-85080089938,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Yan C.-X., Li J., Shen X., Luo L., Li Y., Li M.-Y.",57216085881;57216088118;57209707391;57216085953;57211570904;57216087507;,Biological Product Development Strategies for Prevention and Treatment of Coronavirus Disease 2019,2020,Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition,51,2,,139,145,,,10.12182/20200360506,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082560891&doi=10.12182%2f20200360506&partnerID=40&md5=6f1ae7e445f6b59ff2e0b0a33bd563e4,"State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases,West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China; Chengdu Institute of Biological Products, Chengdu, 610023, China; Department of Medical Microbiology, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, 610041, China","Yan, C.-X., State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases,West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China; Li, J., State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases,West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China; Shen, X., State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases,West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China; Luo, L., Chengdu Institute of Biological Products, Chengdu, 610023, China; Li, Y., State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases,West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China; Li, M.-Y., Department of Medical Microbiology, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, 610041, China","Coronavirus disease 2019 (COVID-19) caused by the novel coronavirus, also known as severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), has become a Public Health Emergency of International Concern. Due to the large infection population, broad transmissibility and high mortality, it is urgent to find out the efficient and specific methods to prevent and treat COVID-19. As biological products have broadly applied in the prevention and treatment of severe epidemic diseases, they are promising in blocking novel coronavirus infection. According to the research advances of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), we reviewed the potential application of biological products such as interferon, convalescent plasma, intestinal micro-ecological regulators, vaccines and therapeutic antibodies, etc. , on prevention and treatment of COVID-19. May this review be helpful for conquering COVID-19 in the near future. Copyright© by Editorial Board of Journal of Sichuan University (Medical Science Edition).",Biological products; COVID-19; MERS; SARS; SARS-CoV-2,,,,,NLM (Medline),1672173X,,,32220178,Chinese,Sichuan Da Xue Xue Bao Yi Xue Ban,Review,Final,,Scopus,2-s2.0-85082560891,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Jeong Y.S.,57215858000;,2019 novel coronavirus disease outbreak and molecular genetic characteristics of severe acute respiratory syndrome-coronavirus-2,2020,Journal of Bacteriology and Virology,50,1,,1,8,,,10.4167/jbv.2020.50.1.001,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082127342&doi=10.4167%2fjbv.2020.50.1.001&partnerID=40&md5=1c81f94203c5dfd16976888444a16b4c,"Department of Biology, College of Sciences, Kyung Hee University, Seoul, South Korea","Jeong, Y.S., Department of Biology, College of Sciences, Kyung Hee University, Seoul, South Korea","The 2019 novel coronavirus disease (COVID-19) outbreaks that emerged in Wuhan city, Hubei province, have led to a formidable number of confirmed cases that resulted in >5,700 deaths globally, including 143 countries in all 6 continents. The World Health Organization declared a Public Health Emergency of International Concern with a very high level of global risk assessment. Severe acute respiratory syndrome (SARS)-coronavirus-2 (SARS-CoV-2), the agent of COVID-19, has >79% nucleotide sequence homology to SARS-CoV; therefore, both belong to the genus betacoronavirus and subgenus sarbecovirus. The S1 domains of the two appeared to share the cellular receptor ACE2, but revealed a much higher S1-ACE2 binding affinity. As seen in many other human coronaviruses, SARS-CoV-2 also shows respiratory infection, but the basic reproductive number (R0) in transmission and the clinical latency are quite dissimilar from those of SARS-or MERS-CoVs. Many scientists infer that the time point of cross-barrier transfer from bats to mediate animals or to humans should be a rather recent event based on the full-length genome analyses obtained from the very first patients. Copy-choice polymerization, which often leads to a significant genome recombination rate in most coronaviruses, predicts the continued emergence of novel coronaviruses. © 2020 Journal of Bacteriology and Virology.",COVID-19; Genome recombination; Human coronaviruses; SARS-CoV-2,,"Master, P.S., Perlman, S., Coronaviridae In Fields Virology 6th Ed, pp. 825-858. , p; Cui, J., Li, F., Shi, Z.L., Origin and evolution of pathogenic coronaviruses (2019) Nat Rev Microbiol, 17, pp. 181-192; Su, S., Wong, G., Shi, W., Liu, J., Lai, A.C.K., Zhou, J., Epidemiology, genetic recombination, and pathogenesis of coronaviruses (2016) Trends Microbiol, 24, pp. 490-502; Xu, X., Chen, P., Wang, J., Feng, J., Zhou, H., Li, X., Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission (2020) Sci China Life Sci, 63, pp. 457-460; Menachery, V.D., Yount, B.L., Debbink, K., Agnihothram, S., Gralinski, L.E., Plante, J.A., A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence (2015) Nat Med, 21, pp. 1508-1513; Gorbalenya, A.E., Baker, S.C., Baric, R.S., de Groot, R.J., Drosten, C., Gulyaeva, A.A., Severe acute respiratory syndrome-related coronavirus: The species and its viruses-a statement of the Coronavirus Study Group Biorxiv; https://www.who.int/emergencies/diseases/novel-coronavirus-2019; Lu, R., Zhao, X., Li, J., Niu, P., Yang, B., Wu, H., Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding (2020) Lancet, 395, pp. 565-574; Hayman, D.T., Bats as viral reservoirs (2016) Annu Rev Virol, 3, pp. 77-99; Luis, A.D., Hayman, D.T., O’Shea, T.J., Cryan, P.M., Gilbert, A.T., Pulliam, J.R., A comparison of bats and rodents as reservoirs of zoonotic viruses: Are bats special? (2013) Proc Biol Sci, 280; Callaway, E., Cyranoski, D., What scientists want to know about coronavirus outbreak (2020) Nature (News in Focus), 577, pp. 605-607; Wrapp, D., Wang, N., Corbett, K.S., Goldsmith, J.A., Hsieh, C.L., Abiona, O., Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation (2020) Science; Cohen, J., Mining coronavirus genomes for clues to the outbreak’s origins (2020) Science; Flint, J., Racaniello, V.R., Rall, G.F., Skalka, A.M., Emergence In Principles of Virology, pp. 342-354; Bai, Y., Yao, L., Wei, T., Tian, F., Jin, D.Y., Chen, L., Wang, M., Presumed asymptomatic carrier transmission of COVID-19 (2020) JAMA; Al-Tawfig, J.A., Zumla, A., Memish, Z.A., Travel implications of emerging coronaviruses: SARS and MERS-CoV (2014) Travl Med Infect Dis, 12, pp. 422-428; Noh, J.W., Yoo, K.B., Kwon, Y.D., Hong, J.H., Lee, Y., Park, K., Effect of information disclosure policy on control of infectious disease: MERS-CoV outbreak in South Korea (2020) Int J Environ Res Public Health, 17; Bagamian, K.H., Towner, J.S., Kuenzi, A.J., Douglass, R.J., Rollin, P.E., Waller, L.A., Transmission Ecology of Sin Nombre Hantavirus in Naturally Infected North American Deermouse Populations in Outdoor Enclosures (2012) Plos One, 7; Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382, pp. 727-733; Dennehy, J.J., Evolutionary ecology of virus emergence (2017) Ann N Y Acad Sci, 1389, pp. 124-146","Jeong, Y.S.; Department of Biology, College of Sciences, Kyung Hee UniversitySouth Korea; email: ysjeong@khu.ac.kr",,The Korean Society for Mocrobiology / The Korean Society of Virology,15982467,,JBVOA,,Korean,J. Bacteriol. Virol.,Review,Final,Open Access,Scopus,2-s2.0-85082127342,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Nicastri E., D'Abramo A., Faggioni G., De Santis R., Mariano A., Lepore L., Molinari F., Petralito G., Fillo S., Munzi D., Corpolongo A., Bordi L., Carletti F., Castiletti C., Colavita F., Lalle E., Bevilacqua N., Giancola M.L., Scorzolini L., Lanini S., Palazzolo C., De Domenico A., Spinelli M.A., Scognamiglio P., Piredda P., Iacomino R., Mone A., Puro V., Petrosillo N., Battistini A., Vairo F., Lista F., Ippolito G., On Behalf Of Inmi And The Italian Army Covid-Study Groups",57211086423;55485796200;14015708400;7007045780;57203678667;57194110887;57215923668;57211591447;7801628599;57211219288;8718859500;8963521400;6603224520;57215924188;57192341341;23489455700;6602491600;6603873416;6507358073;57202377000;57215795104;57215923728;57215924577;6602227272;57196711729;57215923693;57215924380;57211101049;7004966952;57215924293;36846052400;6601971861;7102706668;57215923561;,"Coronavirus disease (COVID-19) in a paucisymptomatic patient: epidemiological and clinical challenge in settings with limited community transmission, Italy, February 2020",2020,Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin,25,11,,,,,,10.2807/1560-7917.ES.2020.25.11.2000230,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082380423&doi=10.2807%2f1560-7917.ES.2020.25.11.2000230&partnerID=40&md5=783bb305916c3c6e23de7513775ec558,"These authors contributed equally to this article and share first authorship; National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, Rome, Italy; Scientific Department, Italian Army Medical Center, Rome, Italy; Clinical Sciences Department, Italian Army Medical Center, Rome, Italy; Italian Army Surgeon General Office, Rome, Italy; These authors contributed equally to this article and share last authorship; members of these groups are acknowledged at the end of the article","Nicastri, E., These authors contributed equally to this article and share first authorship, National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, Rome, Italy; D'Abramo, A., These authors contributed equally to this article and share first authorship, National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, Rome, Italy; Faggioni, G., Scientific Department, Italian Army Medical Center, Rome, Italy; De Santis, R., Scientific Department, Italian Army Medical Center, Rome, Italy; Mariano, A., National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, Rome, Italy; Lepore, L., National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, Rome, Italy; Molinari, F., Scientific Department, Italian Army Medical Center, Rome, Italy; Petralito, G., Scientific Department, Italian Army Medical Center, Rome, Italy; Fillo, S., Scientific Department, Italian Army Medical Center, Rome, Italy; Munzi, D., Scientific Department, Italian Army Medical Center, Rome, Italy; Corpolongo, A., National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, Rome, Italy; Bordi, L., National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, Rome, Italy; Carletti, F., National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, Rome, Italy; Castiletti, C., National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, Rome, Italy; Colavita, F., National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, Rome, Italy; Lalle, E., National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, Rome, Italy; Bevilacqua, N., National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, Rome, Italy; Giancola, M.L., National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, Rome, Italy; Scorzolini, L., National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, Rome, Italy; Lanini, S., National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, Rome, Italy; Palazzolo, C., National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, Rome, Italy; De Domenico, A., Clinical Sciences Department, Italian Army Medical Center, Rome, Italy; Spinelli, M.A., Scientific Department, Italian Army Medical Center, Rome, Italy; Scognamiglio, P., National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, Rome, Italy; Piredda, P., Clinical Sciences Department, Italian Army Medical Center, Rome, Italy; Iacomino, R., Clinical Sciences Department, Italian Army Medical Center, Rome, Italy; Mone, A., Clinical Sciences Department, Italian Army Medical Center, Rome, Italy; Puro, V., National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, Rome, Italy; Petrosillo, N., National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, Rome, Italy; Battistini, A., Italian Army Surgeon General Office, Rome, Italy; Vairo, F., National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, Rome, Italy; Lista, F., Scientific Department, Italian Army Medical Center, Rome, Italy, These authors contributed equally to this article and share last authorship; Ippolito, G., National Institute for Infectious Diseases 'Lazzaro Spallanzani' IRCCS, Rome, Italy, These authors contributed equally to this article and share last authorship; On Behalf Of Inmi And The Italian Army Covid-Study Groups, members of these groups are acknowledged at the end of the article",Data concerning the transmission of the novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) in paucisymptomatic patients are lacking. We report an Italian paucisymptomatic case of coronavirus disease 2019 with multiple biological samples positive for SARS-CoV-2. This case was detected using the World Health Organization protocol on cases and contact investigation. Current discharge criteria and the impact of extra-pulmonary SARS-CoV-2 samples are discussed.,COVID-19; Italy; paucisymptomatic case,,,,,NLM (Medline),15607917,,,32209164,English,Euro Surveill.,Article,Final,Open Access,Scopus,2-s2.0-85082380423,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "DU H.-Z., HOU X.-Y., MIAO Y.-H., HUANG B.-S., LIU D.-H.",57216038994;57193898075;57216040442;55459833500;55955408200;,Traditional Chinese Medicine: an effective treatment for 2019 novel coronavirus pneumonia (NCP),2020,Chinese Journal of Natural Medicines,18,3,,206,210,,,10.1016/S1875-5364(20)30022-4,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082537067&doi=10.1016%2fS1875-5364%2820%2930022-4&partnerID=40&md5=7e09a9583d6b35af64935c9c3ad870c2,"School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, 430065, China; Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing, 210009, China","DU, H.-Z., School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, 430065, China; HOU, X.-Y., Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing, 210009, China; MIAO, Y.-H., School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, 430065, China; HUANG, B.-S., School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, 430065, China; LIU, D.-H., School of Pharmacy, Hubei University of Chinese Medicine, Wuhan, 430065, China","The novel coronavirus pneumonia broke out in 2019 and spread rapidly. In 30 different countries, there are over seventy thousand patients have been diagnosed in total. Therefore, it is urgent to develop the effective program to prevent and treat for the novel coronavirus pneumonia. In view of Traditional Chinese Medicine has accumulated a solid theoretical foundation of plague in ancient and recent decades. Meanwhile, Traditional Chinese Medicine can provide the more effective and personalized treatment via adjusting the specific medicine for each patient based on the different syndromes. In addition, TCM often has different effect on the distinct stages of diseases, contributing to the prevention, treatment and rehabilitation. Nowadays, TCM has exhibited decent effect in the in the fight against NCP. Therefore, it is convinced that Traditional Chinese Medicine is an effective treatment for 2019 novel coronavirus pneumonia. © 2020 China Pharmaceutical University",Infectious diseases; Inflammation; Novel coronavirus (2019-nCoV); Novel coronavirus pneumonia; Traditional Chinese Medicine,,"National Health Commission of the People's Republic of China, Transcript of press conference (2020), http://www.nhc.gov.cn/wjw/index_gzbd.shtml; Wang, Z., Chen, X., Lu, Y., Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined Chinese and Western medicine treatment [J] (2020) Biosci Trends, , [Epub ahead of print]; National Administration of Traditional Chinese Medicine, Progress has been made in the screening of effective prescriptions for traditional Chinese medicine http://www.satcm.gov.cn/a/gzdt/; Liu, X., Zhang, M., He, L., Chinese herbs combined with Western medicine for severe acute respiratory syndrome (SARS) [J] (2012) Cochrane Database Syst Rev, 17, p. 10. , CD004882; Ding, Y.W., Zeng, L.J., Li, R.F., The Chinese prescription lianhuaqingwen capsule exerts anti-influenza activity through the inhibition of viral propagation and impacts immune function [J] (2017) BMC Complem Altern Med, 17, p. 130; Liu, L., Yin, H.H., Liu, D., Zero Health Worker Infection: Experiences From the China Ebola Treatment Unit During the Ebola Epidemic in Liberia [J] (2017) Disaster Med Public, 11 (2), pp. 262-266; Ma, Y.X., Chen, M., Guo, Y.L., Prevention and treatment of infectious diseases by traditional Chinese medicine: a commentary [J] (2019) APMIS, 127 (5), pp. 372-384; World Health Organization, Summary of probable SARS cases with onset of illness from 1 November 2002 to 31 July 2003 https://www.who.int/csr/sars/country/table2004_04_21/en/; Chinese Academy of Sciences, Guangdong provincial hospital of traditional Chinese medicine adopts integrated traditional Chinese and western medicine to treat SARS http://www.cas.cn/zt/kjzt/zykfd/; Zhao, H., Chen, F.X., Ma, S.F., The role of emergency management in the treatment of emerging infectious disease—the first case of human infection with the H7N9 flu patient of Beijing [J] (2014) Chinese Hospitals, 18 (2), pp. 40-42; National Health Commission of the People's Republic of China, Diagnosis and treatment of MERS cases (2015), http://www.nhc.gov.cn/wjw/gfxwjj/list.shtml; Qi, X.T., Zhao, C.Y., Zhang, J.X., Current evaluation situation and research strategies on enhanced immune function of health food containing Chinese materia medica [J] (2019) Chin J Chin Mater Med, 44 (5), pp. 875-879; Fan, K.J., Li, Y.W., Wu, J., The Traditional Chinese Medicine Fufang Shatai Heji (STHJ) Enhances Immune Function in Cyclophosphamide-Treated Mice [J] (2020) Evid-Based Compl Alt, 2020; Zhang, A.L., Wang, D.Y., Li, J.Y., The effect of aqueous extract of Xinjiang Artemisia rupestris L. (an influenza virus vaccine adjuvant) on enhancing immune responses and reducing antigen dose required for immunity [J] (2017) PLoS One, 12 (8); Novel Coronavirus Pneumonia Emergency Response Epidemiology Team, The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China [J] (2020) Zhonghua Liu Xing Bing Xue Za Zhi, 41 (2), pp. 145-151; Han, Y.Y., Zhao, M.R., Shi, Y., Application of integrative medicine protocols on treatment of coronavirus disease 2019 [J] (2020) Chin Tradit Herb Drugs, , [Epub ahead of print]; National Health Commission of the People's Republic of China, A notice on the issuance of the diagnosis and treatment programme for novel coronavirus pneumonia (sixth edition) http://www.nhc.gov.cn/yzygj/s7653p/new_list.shtml; National Health Commission of the People's Republic of China, The latest situation of new coronavirus pneumonia http://www.nhc.gov.cn/xcs/xxgzbd/gzbd_index.shtml; National Administration of Traditional Chinese Medicine, News conference on the prevention and control of the epidemic in Hubei province http://www.satcm.gov.cn/a/gzdt/; Lv, R.B., Wang, W.J., Li, X., Clinical observation of 63 suspected cases of new coronavirus pneumonia treated with lianhua qingwen [J] (2020) J Tradit Chin Med, , [Epub ahead of print]; Li, C.Y., Zhang, X.Y., Liu, S., Current Evidence and Research Prospects of Xuebijing Injection in Treating Novel Coronavirus-infected Pneumonia (COVID-19) (2020) World Sci Technol Modern Tradit Chin Med Mater Med, , [Epub ahead of print]; Yao, K.T., Liu, M.Y., Li, X., A retrospective clinical analysis of pneumonia in the treatment of novel coronavirus infection with lianhua qingwen [J] (2020) Chin J Exp Tradit Med Formul, , [Epub ahead of print]","LIU, D.-H.; School of Pharmacy, Hubei University of Chinese MedicineChina; email: liudahui@hbtcm.edu.cn",,China Pharmaceutical University,18755364,,ZTYHA,,English,Chin. J. Nat. Med.,Review,Final,Open Access,Scopus,2-s2.0-85082537067,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Li J.-Y., You Z., Wang Q., Zhou Z.-J., Qiu Y., Luo R., Ge X.-Y.",57192312600;57215609063;57207885215;57215606676;57214161427;35230419100;35781787600;,The epidemic of 2019-novel-coronavirus (2019-nCoV) pneumonia and insights for emerging infectious diseases in the future,2020,Microbes and Infection,22,2,,80,85,,1,10.1016/j.micinf.2020.02.002,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081340190&doi=10.1016%2fj.micinf.2020.02.002&partnerID=40&md5=a4eadb54cb6507aca200811add441a66,"Institute of Pathogen Biology and Immunology, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University, Changsha, Hunan 410082, China; State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, China; Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, Hubei 430070, China","Li, J.-Y., Institute of Pathogen Biology and Immunology, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University, Changsha, Hunan 410082, China; You, Z., Institute of Pathogen Biology and Immunology, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University, Changsha, Hunan 410082, China; Wang, Q., Institute of Pathogen Biology and Immunology, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University, Changsha, Hunan 410082, China; Zhou, Z.-J., Institute of Pathogen Biology and Immunology, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University, Changsha, Hunan 410082, China; Qiu, Y., Institute of Pathogen Biology and Immunology, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University, Changsha, Hunan 410082, China; Luo, R., State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, Hubei 430070, China; Ge, X.-Y., Institute of Pathogen Biology and Immunology, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University, Changsha, Hunan 410082, China","At the end of December 2019, a novel coronavirus, 2019-nCoV, caused an outbreak of pneumonia spreading from Wuhan, Hubei province, to the whole country of China, which has posed great threats to public health and attracted enormous attention around the world. To date, there are no clinically approved vaccines or antiviral drugs available for these human coronavirus infections. Intensive research on the novel emerging human infectious coronaviruses is urgently needed to elucidate their route of transmission and pathogenic mechanisms, and to identify potential drug targets, which would promote the development of effective preventive and therapeutic countermeasures. Herein, we describe the epidemic and etiological characteristics of 2019-nCoV, discuss its essential biological features, including tropism and receptor usage, summarize approaches for disease prevention and treatment, and speculate on the transmission route of 2019-nCoV. © 2020 Institut Pasteur",2019-nCoV; ACE2; Bat; Pneumonia; SARS-CoV; Spike,"antivirus agent; virus spike protein; COVID-19; severe acute respiratory syndrome coronavirus 2; virus receptor; 2019 novel coronavirus; antiviral therapy; Article; China; clinical feature; Coronaviridae; Coronavirus infection; epidemic; genomics; human; infection prevention; nonhuman; priority journal; public health; receptor binding; viral tropism; virus identification; virus pneumonia; virus transmission; Betacoronavirus; communicable disease; Coronavirus infection; epidemic; genetics; pathogenicity; phylogeny; virology; virus genome; virus pneumonia; Antiviral Agents; Betacoronavirus; China; Communicable Diseases, Emerging; Coronavirus Infections; Epidemics; Genome, Viral; Humans; Phylogeny; Pneumonia, Viral; Receptors, Virus; Viral Tropism","Cui, J., Li, F., Shi, Z.L., Origin and evolution of pathogenic coronaviruses (2019) Nat Rev Microbiol, 17, pp. 181-192; Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382 (8), pp. 727-733; https://www.who.int/emergencies/diseases/novel-coronavirus-2019, WHO; Chan, J.F., Yuan, S.F., Kok, K.H., To, K.K., Chu, H., Yang, J., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, 395 (10223), pp. 514-523; Wang, C., Horby, P.W., Hayden, F.G., Gao, G.F., A novel coronavirus outbreak of global health concern (2020) Lancet, 395 (10223), pp. 470-473; Chinese, C.D.C., http://2019ncov.chinacdc.cn/2019-ncov/; Tatem, A.J., Rogers, D.J., Hay, S.I., Global transport networks and infectious disease spread (2006) Adv Parasitol, 62, pp. 293-343; 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Ge, X.Y., Li, J., Yang, X.L., Chmura, A.A., Zhu, G., Epstein, J.H., Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor (2013) Nature, 503, pp. 535-538; Azhar, E.I., El-Kafrawy, S.A., Farraj, S.A., Hassan, A.M., Al-Saeed, M.S., Hashem, A.M., Evidence for camel-to-human transmission of MERS Coronavirus (2014) N Engl J Med, 370, pp. 2499-2505; Kupferschmidt, K., The camel connection (2014) Science, 343, pp. 1422-1425; Chinese, I., https://m.thepaper.cn/newsDetail_forward_5835114?from=groupmessage&isappinstalled=0.2020; Emery, S.L., Erdman, D.D., Bowen, M.D., Newton, B.R., Winchell, J.M., Meyer, R.F., Real-time reverse transcription-polymerase chain reaction assay for SARSassociated coronavirus (2004) Emerg Infect Dis, 10, pp. 311-316; Gaunt, E.R., Hardie, A., Claas, E.C., Simmonds, P., Templeton, K.E., Epidemiology and clinical presentations of the four human coronaviruses 229E, HKU1, NL63, and OC43 detected over 3 years using a novel multiplex real-time PCR method (2010) J Clin Microbiol, 48, pp. 2940-2947; Xu, Z.J., Peng, C., Shi, Y.L., Zhu, Z.D., Mu, K.J., Wang, X.Y., Nelfinavir was predicted to be a potential inhibitor of 2019-nCov main protease by an integrative approach combining homology modelling, molecular docking and binding free energy calculation (2020); Tai, D., Pharmacologic treatment of SARS: current knowledge and recommendations (2007) Ann Acad Med Singapore, 36, pp. 438-443; Chu, C.M., Cheng, V.C., Hung, I.F., Wong, M.M., Chan, K.H., Chan, K.S., Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings (2004) Thorax, 59, pp. 252-256; Nukoolkarn, V.L., Lee, V.S., Malaisree, M., Aruksakulwong, O., Hannongbua, S., Molecular dynamic simulations analysis of ritonavir and lopinavir as SARSCoV 3CL(pro) inhibitors (2008) J Theor Biol, 254, pp. 861-867; Chong, Y.P., Song, J.Y., Seo, Y.B., Choi, J.P., Shin, H.S., Team, R.R., Antiviral treatment guidelines for middle east respiratory syndrome (2015) Infect Chemother, 47, pp. 212-222; Arabi, Y.M., Alothman, A., Balkhy, H.H., Al-Dawood, A., c, S., Harbi, S.A., Treatment of Middle East Respiratory Syndrome with a combination of lopinavirritonavir and interferon-beta1b (MIRACLE trial): study protocol for a randomized controlled trial (2018) Trials, 19, p. 81; Wang, M.L., Cao, R., Zhang, L., Yang, X.L., Liu, J., Xu, M.Y., Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro (2020) Cell Res","Ge, X.-Y.; Institute of Pathogen Biology and Immunology, College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan UniversityChina; email: xyge@hnu.edu.cn",,Elsevier Masson SAS,12864579,,MCINF,32087334,English,Microbes Infect.,Article,Final,Open Access,Scopus,2-s2.0-85081340190,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wang Y., Cui X., Chen X., Yang S., Ling Y., Song Q., Zhu S., Sun L., Li C., Li Y., Deng X., Delwart E., Zhang W.",56048948900;57214080948;57214086458;24529429100;57214724238;57203908515;57214082857;57214080228;57205565811;55650739300;55605616800;7003328241;56369507900;,A recombinant infectious bronchitis virus from a chicken with a spike gene closely related to that of a turkey coronavirus,2020,Archives of Virology,165,3,,703,707,,,10.1007/s00705-019-04488-3,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078156470&doi=10.1007%2fs00705-019-04488-3&partnerID=40&md5=210cda14e906b2e776aa7f1c244db3ea,"College of Animal Sciences and Technologies, Anhui Agricultural University, Hefei, 230036, China; School of Medicine, Jiangsu University, 310 Xuefu Road, Zhenjiang, Jiangsu 202103, China; Vitalant Research Institute, 270 Masonic Avenue, San Francisco, CA 941187, United States; Department of Laboratory Medicine, University of California, San Francisco, CA 94143, United States","Wang, Y., College of Animal Sciences and Technologies, Anhui Agricultural University, Hefei, 230036, China, School of Medicine, Jiangsu University, 310 Xuefu Road, Zhenjiang, Jiangsu 202103, China; Cui, X., College of Animal Sciences and Technologies, Anhui Agricultural University, Hefei, 230036, China; Chen, X., School of Medicine, Jiangsu University, 310 Xuefu Road, Zhenjiang, Jiangsu 202103, China; Yang, S., School of Medicine, Jiangsu University, 310 Xuefu Road, Zhenjiang, Jiangsu 202103, China; Ling, Y., School of Medicine, Jiangsu University, 310 Xuefu Road, Zhenjiang, Jiangsu 202103, China; Song, Q., School of Medicine, Jiangsu University, 310 Xuefu Road, Zhenjiang, Jiangsu 202103, China; Zhu, S., School of Medicine, Jiangsu University, 310 Xuefu Road, Zhenjiang, Jiangsu 202103, China; Sun, L., School of Medicine, Jiangsu University, 310 Xuefu Road, Zhenjiang, Jiangsu 202103, China; Li, C., School of Medicine, Jiangsu University, 310 Xuefu Road, Zhenjiang, Jiangsu 202103, China; Li, Y., College of Animal Sciences and Technologies, Anhui Agricultural University, Hefei, 230036, China; Deng, X., Vitalant Research Institute, 270 Masonic Avenue, San Francisco, CA 941187, United States, Department of Laboratory Medicine, University of California, San Francisco, CA 94143, United States; Delwart, E., Vitalant Research Institute, 270 Masonic Avenue, San Francisco, CA 941187, United States, Department of Laboratory Medicine, University of California, San Francisco, CA 94143, United States; Zhang, W., School of Medicine, Jiangsu University, 310 Xuefu Road, Zhenjiang, Jiangsu 202103, China","Using viral metagenomics, the complete genome sequence of an infectious bronchitis virus (IBV) strain (named ahysx-1) from a fecal sample from a healthy chicken in Anhui province, China, was determined. The genome sequence of ahysx-1 was found to be very similar to that of IBV strain ck/CH/LLN/131040 (KX252787), except for the spike gene region, which is similar to that of a turkey coronavirus strain (EU022526), suggesting that ahysx-1 is a recombinant. Recombination analysis and phylogenetic analysis based on the genomic sequences of ahysx-1 and other related strains confirmed that ahysx-1 appears to be a recombinant resulting from a recombination event that occurred between a chicken coronavirus and a turkey coronavirus. Further studies need to be performed to determine whether this recombinant IBV strain is pathogenic and whether it is transmitted between chickens and turkeys. © 2020, Springer-Verlag GmbH Austria, part of Springer Nature.",Coronavirus; Genome recombination; Infectious bronchitis virus; Viral metagenomics,"coronavirus spike glycoprotein; animal; Avian infectious bronchitis virus; chicken; Coronavirinae; genetic recombination; genetics; metagenomics; phylogeny; turkey (bird); virology; virus genome; Animals; Chickens; Coronavirus; Genome, Viral; Infectious bronchitis virus; Metagenomics; Phylogeny; Recombination, Genetic; Spike Glycoprotein, Coronavirus; Turkeys","Perlman, S., Netland, J., Coronaviruses post-SARS: update on replication and pathogenesis (2009) Nat Rev Microbiol, 7, pp. 439-450; Menachery, V.D., Graham, R.L., Baric, R.S., Jumping species—a mechanism for coronavirus persistence and survival (2017) Curr Opin Virol, 23, pp. 1-7; Woo, P.C.Y., Lau, S.K.P., Lam, C.S.F., Discovery of Seven Novel Mammalian and Avian Coronaviruses in the Genus Deltacoronavirus Supports Bat Coronaviruses as the Gene Source of Alphacoronavirus and Betacoronavirus and Avian Coronaviruses as the Gene Source of Gammacoronavirus and Deltacoronavirus (2012) J Virol, 86, pp. 3995-4008; Ziebuhr, J., Thiel, V., Gorbalenya, A.E., The autocatalytic release of a putative RNA virus transcription factor from its polyprotein precursor involves two paralogous papain-like proteases that cleave the same peptide bond (2001) J Biol Chem, 276, pp. 33220-33232; Bickerton, E., Maier, H.J., Stevenson-Leggett, P., The S2 Subunit of infectious bronchitis virus beaudette is a determinant of cellular tropism (2018) J Virol, 92, pp. e01044-e1018; Shan, D., Fang, S., Han, Z., Effects of hypervariable regions in spike protein on pathogenicity, tropism, and serotypes of infectious bronchitis virus (2018) Virus Res, 250, pp. 104-113; Goebel, S.J., Hsue, B., Dombrowski, T.F., Masters, P.S., Characterization of the RNA components of a putative molecular switch in the 3’ untranslated region of the murine coronavirus genome (2004) J Virol, 78, pp. 669-682. , COI: 1:CAS:528:DC%2BD2cXjvFaqtg%3D%3D; Zhang, W., Li, L., Deng, X., Viral nucleic acids in human plasma pools (2016) Transfusion, 56, pp. 2248-2255; Deng, X., Naccache, S.N., Ng, T., An ensemble strategy that significantly improves de novo assembly of microbial genomes from metagenomic next-generation sequencing data (2015) Nucleic Acids Res; Zhang, W., Yang, S., Shan, T., Virome comparisons in wild-diseased and healthy captive giant pandas (2017) Microbiome, 5, p. 90; Skewes-Cox, P., Sharpton, T.J., Pollard, K.S., DeRisi, J.L., Profile hidden Markov models for the detection of viruses within metagenomic sequence data (2014) PLoS One, 9; Johnson, L.S., Eddy, S.R., Portugaly, E., Hidden Markov model speed heuristic and iterative HMM search procedure (2010) BMC Bioinformatics, 11, p. 431; Eddy, S.R., A new generation of homology search tools based on probabilistic inference (2009) Genome Inform, 23, pp. 205-211. , PID: 20180275; Finn, R.D., Clements, J., Eddy, S.R., HMMER web server: interactive sequence similarity searching (2011) Nucleic Acids Res, 39, pp. W29-W37; Cao, J., Wu, C.-C., Lin, T.L., Complete nucleotide sequence of polyprotein gene 1 and genome organization of turkey coronavirus (2008) Virus Res, 136, pp. 43-49; Larkin, M.A., Blackshields, G., Brown, N.P., Clustal W and Clustal X version 2.0 (2007) Bioinformatics, 23, pp. 2947-2948; Martin, M., Martin, B., Golden, M., RDP4: detection and analysis of recombination patterns in virus genomes (2015) Virus Evol, 1, p. vev003; Tamura, K., Peterson, D., Peterson, N., MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods (2011) Mol Biol Evol, 28, pp. 2731-2739; Lin, S.-Y., Chen, H.-W., Infectious bronchitis virus variants: molecular analysis and pathogenicity investigation (2017) Int J Mol Sci, 18, p. 2030; Jackwood, M.W., Boynton, T.O., Hilt, D.A., Emergence of a group 3 coronavirus through recombination (2010) Virology, 398, pp. 98-108","Li, Y.; College of Animal Sciences and Technologies, Anhui Agricultural UniversityChina; email: liyu@ahau.edu.cn",,Springer,3048608,,ARVID,31982944,English,Arch. Virol.,Article,Final,Open Access,Scopus,2-s2.0-85078156470,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Subspecialty Group of Hematology and Oncology, Society of Pediatrics of Hubei",,Standardized management guideline for pediatric wards of hematology and oncology during the epidemic of coronavirus disease 2019,2020,Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics,22,3,,177,182,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082285125&partnerID=40&md5=f1960887b5508bcda833336f44496c6f,,"Subspecialty Group of Hematology and Oncology, Society of Pediatrics of Hubei","With the spread of coronavirus disease 2019 (COVID-19) and growing knowledge of its diagnosis and treatment, it has been clear that children are also susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The children with hematological tumors are a special population with immunosuppression and special therapeutic characteristics. Here the management guideline for pediatric wards of hematology and oncology during COVID-19 epidemic is established based on the features of children with hematological tumors.",,"Betacoronavirus; child; Coronavirinae; Coronavirus infection; epidemic; hematologic disease; human; neoplasm; virus pneumonia; Betacoronavirus; Child; Coronavirus; Coronavirus Infections; Epidemics; Hematologic Diseases; Humans; Neoplasms; Pneumonia, Viral",,,,NLM (Medline),10088830,,,32204750,Chinese,Zhongguo Dang Dai Er Ke Za Zhi,Article,Final,,Scopus,2-s2.0-85082285125,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Shang J., Wan Y., Liu C., Yount B., Gully K., Yang Y., Auerbach A., Peng G., Baric R., Li F.",57191992928;55620829000;57191676713;6603564156;57215863698;57192214076;57215863410;57215913710;57205312930;57215864105;,Structure of mouse coronavirus spike protein complexed with receptor reveals mechanism for viral entry,2020,PLoS pathogens,16,3,,e1008392,,,,10.1371/journal.ppat.1008392,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082144826&doi=10.1371%2fjournal.ppat.1008392&partnerID=40&md5=f1c39757f9d7a5ee7e0656438aeacb2f,"Department of Veterinary and Biomedical Sciences, University of Minnesota, Saint Paul, Minnesota, United States of America; Department of Epidemiology, University of North Carolina, Chapel HillNC, United States; College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China","Shang, J., Department of Veterinary and Biomedical Sciences, University of Minnesota, Saint Paul, Minnesota, United States of America; Wan, Y., Department of Veterinary and Biomedical Sciences, University of Minnesota, Saint Paul, Minnesota, United States of America; Liu, C., Department of Veterinary and Biomedical Sciences, University of Minnesota, Saint Paul, Minnesota, United States of America; Yount, B., Department of Epidemiology, University of North Carolina, Chapel HillNC, United States; Gully, K., Department of Epidemiology, University of North Carolina, Chapel HillNC, United States; Yang, Y., Department of Veterinary and Biomedical Sciences, University of Minnesota, Saint Paul, Minnesota, United States of America; Auerbach, A., Department of Veterinary and Biomedical Sciences, University of Minnesota, Saint Paul, Minnesota, United States of America; Peng, G., College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China; Baric, R., Department of Epidemiology, University of North Carolina, Chapel HillNC, United States; Li, F., Department of Veterinary and Biomedical Sciences, University of Minnesota, Saint Paul, Minnesota, United States of America","Coronaviruses recognize a variety of receptors using different domains of their envelope-anchored spike protein. How these diverse receptor recognition patterns affect viral entry is unknown. Mouse hepatitis coronavirus (MHV) is the only known coronavirus that uses the N-terminal domain (NTD) of its spike to recognize a protein receptor, CEACAM1a. Here we determined the cryo-EM structure of MHV spike complexed with mouse CEACAM1a. The trimeric spike contains three receptor-binding S1 heads sitting on top of a trimeric membrane-fusion S2 stalk. Three receptor molecules bind to the sides of the spike trimer, where three NTDs are located. Receptor binding induces structural changes in the spike, weakening the interactions between S1 and S2. Using protease sensitivity and negative-stain EM analyses, we further showed that after protease treatment of the spike, receptor binding facilitated the dissociation of S1 from S2, allowing S2 to transition from pre-fusion to post-fusion conformation. Together these results reveal a new role of receptor binding in MHV entry: in addition to its well-characterized role in viral attachment to host cells, receptor binding also induces the conformational change of the spike and hence the fusion of viral and host membranes. Our study provides new mechanistic insight into coronavirus entry and highlights the diverse entry mechanisms used by different viruses.",,"carcinoembryonic antigen; Ceacam1 protein, mouse; coronavirus spike glycoprotein; MHV surface projection glycoprotein; protein binding; recombinant protein; S protein, severe acute respiratory syndrome coronavirus; virus receptor; alpha helix; animal; chemistry; cryoelectron microscopy; HEK293 cell line; human; membrane fusion; metabolism; molecular model; mouse; Murine hepatitis virus; physiology; protein conformation; protein degradation; protein domain; protein multimerization; SARS coronavirus; tumor cell line; ultrastructure; virus attachment; virus entry; Animals; Carcinoembryonic Antigen; Cell Line, Tumor; Cryoelectron Microscopy; HEK293 Cells; Humans; Membrane Fusion; Mice; Models, Molecular; Murine hepatitis virus; Protein Binding; Protein Conformation; Protein Conformation, alpha-Helical; Protein Domains; Protein Multimerization; Proteolysis; Receptors, Virus; Recombinant Proteins; SARS Virus; Spike Glycoprotein, Coronavirus; Virus Attachment; Virus Internalization",,,,NLM (Medline),15537374,,,32150576,English,PLoS Pathog.,Article,Final,Open Access,Scopus,2-s2.0-85082144826,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Luan R.-S., Wang X., Sun X., Chen X.-S., Zhou T., Liu Q.-H., Lü X., Wu X.-P., Gu D.-Q., Tang M.-S., Cui H.-J., Shan X.-F., Ouyang J., Zhang B., Zhang W., Sichuan University Covid- E.R.G.",57216087968;57216088121;57215056080;57216087803;57215531052;57189325700;57202606942;57216086062;57216085826;57216086592;57216086562;55649737300;57216086223;57216088048;57215936623;57216087345;,"Epidemiology, Treatment, and Epidemic Prevention and Control of the Coronavirus Disease 2019: a Review",2020,Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition,51,2,,131,138,,,10.12182/20200360505,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082561561&doi=10.12182%2f20200360505&partnerID=40&md5=a449076cff7d0dadb5acff70a790799a,"Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, 610041, China; Department of Epidemiology and Biostatistics, First Hospital Affiliated to AMUChongqing 400038, China; Chinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Chengdu, 610041, China; School of Cybersecurity, Sichuan University, Chengdu, 610065, China; Big Data Research Center, University of Electronic Science and Technology of China, Chengdu, 611731, China; School of Computer Science, Sichuan University, Chengdu, 610065, China; College of Systems Engineering, National University of Defense Technology, Changsha, 410073, China; Sichuan Center for Disease Control and Prevention, Chengdu, 610041, China; Department of Pharmacy, First Affiliated Hospital to Chongqing Medical UniversityChongqing 400016, China; Department of Pharmacy, Chongqing Public Health Medical CenterChongqing 400036, China; West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, 610041, China; Sichuan University, Chengdu, 610041, China","Luan, R.-S., Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, 610041, China; Wang, X., Department of Epidemiology and Biostatistics, First Hospital Affiliated to AMUChongqing 400038, China; Sun, X., Chinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Chengdu, 610041, China; Chen, X.-S., School of Cybersecurity, Sichuan University, Chengdu, 610065, China; Zhou, T., Big Data Research Center, University of Electronic Science and Technology of China, Chengdu, 611731, China; Liu, Q.-H., School of Computer Science, Sichuan University, Chengdu, 610065, China; Lü, X., College of Systems Engineering, National University of Defense Technology, Changsha, 410073, China; Wu, X.-P., Sichuan Center for Disease Control and Prevention, Chengdu, 610041, China; Gu, D.-Q., Department of Epidemiology and Biostatistics, First Hospital Affiliated to AMUChongqing 400038, China; Tang, M.-S., Department of Epidemiology and Biostatistics, First Hospital Affiliated to AMUChongqing 400038, China; Cui, H.-J., Department of Epidemiology and Biostatistics, First Hospital Affiliated to AMUChongqing 400038, China; Shan, X.-F., Department of Pharmacy, First Affiliated Hospital to Chongqing Medical UniversityChongqing 400016, China; Ouyang, J., Department of Pharmacy, Chongqing Public Health Medical CenterChongqing 400036, China; Zhang, B., Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, 610041, China, Department of Epidemiology and Biostatistics, First Hospital Affiliated to AMUChongqing 400038, China; Zhang, W., West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, 610041, China; Sichuan University Covid-, E.R.G., Sichuan University, Chengdu, 610041, China","This review summarizes the ongoing researches regarding etiology, epidemiology, transmission dynamics, treatment, and prevention and control strategies of the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with comparison to severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV) and pandemic H1N1 virus. SARS-CoV-2 may be originated from bats, and the patients and asymptomatic carriers are the source of epidemic infection. The virus can be transmitted human-to-human through droplets and close contact, and people at all ages are susceptible to this virus. The main clinical symptoms of the patients are fever and cough, accompanied with leukocytopenia and lymphocytopenia. Effective drugs have been not yet available thus far. In terms of the prevention and control strategies, vaccine development as the primary prevention should be accelerated. Regarding the secondary prevention, ongoing efforts of the infected patients and close contacts quarantine, mask wearing promotion, regular disinfection in public places should be continued. Meanwhile, rapid detection kit for serological monitoring of the virus in general population is expected so as to achieve early detection, early diagnosis, early isolation and early treatment. In addition, public health education on this disease and prevention should be enhanced so as to mitigate panic and mobilize the public to jointly combat the epidemic. Copyright© by Editorial Board of Journal of Sichuan University (Medical Science Edition).",Coronavirus disease 2019; Epidemic prevention and control; Epidemiology; Treatment,,,,,NLM (Medline),1672173X,,,32220177,Chinese,Sichuan Da Xue Xue Bao Yi Xue Ban,Review,Final,,Scopus,2-s2.0-85082561561,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Menachery V.D., Dinnon K.H., III, Yount B.L., Jr., McAnarney E.T., Gralinski L.E., Hale A., Graham R.L., Scobey T., Anthony S.J., Wang L., Graham B., Randell S.H., Lipkin W.I., Baric R.S.",24281639500;57194186788;6603564156;57195605429;6505609367;57195605866;57203199836;55874427200;35365788200;35199353800;7201610365;57206327179;7005714572;57205312930;,Trypsin treatment unlocks barrier for zoonotic bat coronavirus infection,2020,Journal of Virology,94,5, e01774-19,,,,2,10.1128/JVI.01774-19,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079471604&doi=10.1128%2fJVI.01774-19&partnerID=40&md5=ea829ffe10ddfd624bba9f150d43e196,"Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, United States; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC, United States; Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY, United States; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, United States; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD, United States; Department of Cell Biology and Physiology, Marsico Lung Institute/Cystic Fibrosis Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States","Menachery, V.D., Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, United States, Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Dinnon, K.H., III, Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC, United States; Yount, B.L., Jr., Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; McAnarney, E.T., Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, United States, Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Gralinski, L.E., Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Hale, A., Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC, United States; Graham, R.L., Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Scobey, T., Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Anthony, S.J., Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY, United States, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, United States; Wang, L., Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD, United States; Graham, B., Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD, United States; Randell, S.H., Department of Cell Biology and Physiology, Marsico Lung Institute/Cystic Fibrosis Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Lipkin, W.I., Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY, United States, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, United States; Baric, R.S., Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC, United States","Traditionally, the emergence of coronaviruses (CoVs) has been attributed to a gain in receptor binding in a new host. Our previous work with severe acute respiratory syndrome (SARS)-like viruses argued that bats already harbor CoVs with the ability to infect humans without adaptation. These results suggested that additional barriers limit the emergence of zoonotic CoV. In this work, we describe overcoming host restriction of two Middle East respiratory syndrome (MERS)-like bat CoVs using exogenous protease treatment. We found that the spike protein of PDF2180-CoV, a MERS-like virus found in a Ugandan bat, could mediate infection of Vero and human cells in the presence of exogenous trypsin. We subsequently show that the bat virus spike can mediate the infection of human gut cells but is unable to infect human lung cells. Using receptor-blocking antibodies, we show that infection with the PDF2180 spike does not require MERS-CoV receptor DPP4 and antibodies developed against the MERS spike receptor-binding domain and S2 portion are ineffective in neutralizing the PDF2180 chimera. Finally, we found that the addition of exogenous trypsin also rescues HKU5-CoV, a second bat group 2c CoV. Together, these results indicate that proteolytic cleavage of the spike, not receptor binding, is the primary infection barrier for these two group 2c CoVs. Coupled with receptor binding, proteolytic activation offers a new parameter to evaluate the emergence potential of bat CoVs and offers a means to recover previously unrecoverable zoonotic CoV strains. IMPORTANCE Overall, our studies demonstrate that proteolytic cleavage is the primary barrier to infection for a subset of zoonotic coronaviruses. Moving forward, the results argue that both receptor binding and proteolytic cleavage of the spike are critical factors that must be considered for evaluating the emergence potential and risk posed by zoonotic coronaviruses. In addition, the findings also offer a novel means to recover previously uncultivable zoonotic coronavirus strains and argue that other tissues, including the digestive tract, could be a site for future coronavirus emergence events in humans. Copyright © 2020 American Society for Microbiology. All Rights Reserved.",Coronavirus; Emergence; MERS-CoV; PDF2180; Spike; Zoonotic,trypsin; virus spike protein; Article; bat; controlled study; correlational study; human; human cell; lung alveolus cell; Middle East respiratory syndrome; nonhuman; nucleotide sequence; priority journal; protein binding; protein cleavage; protein domain; receptor binding; Vero cell line,"Reperant, L.A., Osterhaus, A., AIDS, avian flu, SARS, MERS, Ebola, Zika . . . What next? 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E93. , https://doi.org/10.3390/v10020093; Agnihothram, S., Yount, B.L., Jr., Donaldson, E.F., Huynh, J., Menachery, V.D., Gralinski, L.E., Graham, R.L., Baric, R.S., A mouse model for Betacoronavirus subgroup 2c using a bat coronavirus strain HKU5 variant (2014) mBio, 5, pp. e00047-e00114. , https://doi.org/10.1128/mBio.00047-14; Agnihothram, S., Gopal, R., Yount, B.L., Jr., Donaldson, E.F., Menachery, V.D., Graham, R.L., Scobey, T.D., Baric, R.S., Evaluation of serologic and antigenic relationships between middle eastern respiratory syndrome coronavirus and other coronaviruses to develop vaccine platforms for the rapid response to emerging coronaviruses (2014) J Infect Dis, 209, pp. 995-1006. , https://doi.org/10.1093/infdis/jit609; Johnson, B.A., Graham, R.L., Menachery, V.D., Viral metagenomics, protein structure, and reverse genetics: Key strategies for investigating coronaviruses (2018) Virology, 517, pp. 30-37. , https://doi.org/10.1016/j.virol.2017.12.009; Becker, M.M., Graham, R.L., Donaldson, E.F., Rockx, B., Sims, A.C., Sheahan, T., Pickles, R.J., Denison, M.R., Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice (2008) Proc Natl Acad Sci U S A, 105, pp. 19944-19949. , https://doi.org/10.1073/pnas.0808116105; Rockx, B., Baas, T., Zornetzer, G.A., Haagmans, B., Sheahan, T., Frieman, M., Dyer, M.D., Katze, M.G., Early upregulation of acute respiratory distress syndrome-associated cytokines promotes lethal disease in an aged-mouse model of severe acute respiratory syndrome coronavirus infection (2009) J Virol, 83, pp. 7062-7074. , https://doi.org/10.1128/JVI.00127-09; Sheahan, T., Rockx, B., Donaldson, E., Sims, A., Pickles, R., Corti, D., Baric, R., Mechanisms of zoonotic severe acute respiratory syndrome coronavirus host range expansion in human airway epithelium (2008) J Virol, 82, pp. 2274-2285. , https://doi.org/10.1128/JVI.02041-07; Sheahan, T., Rockx, B., Donaldson, E., Corti, D., Baric, R., Pathways of cross-species transmission of synthetically reconstructed zoonotic severe acute respiratory syndrome coronavirus (2008) J Virol, 82, pp. 8721-8732. , https://doi.org/10.1128/JVI.00818-08; Menachery, V.D., Yount, B.L., Jr., Sims, A.C., Debbink, K., Agnihothram, S.S., Gralinski, L.E., Graham, R.L., Baric, R.S., SARS-like WIV1-CoV poised for human emergence (2016) Proc Natl Acad Sci U S A, 113, pp. 3048-3053. , https://doi.org/10.1073/pnas.1517719113; Menachery, V.D., Yount, B.L., Jr., Debbink, K., Agnihothram, S., Gralinski, L.E., Plante, J.A., Graham, R.L., Baric, R.S., A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence (2015) Nat Med, 21, pp. 1508-1513. , https://doi.org/10.1038/nm.3985; Sheahan, T.P., Sims, A.C., Graham, R.L., Menachery, V.D., Gralinski, L.E., Case, J.B., Leist, S.R., Baric, R.S., Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses (2017) Sci Transl Med, 9, p. eaal3653. , https://doi.org/10.1126/scitranslmed.aal3653; Anthony, S.J., Gilardi, K., Menachery, V.D., Goldstein, T., Ssebide, B., Mbabazi, R., Navarrete-Macias, I., Mazet, J.A., Further evidence for bats as the evolutionary source of Middle East respiratory syndrome coronavirus (2017) mBio, 8, pp. e00373-e00417. , https://doi.org/10.1128/mBio.00373-17; Hofmann, M., Wyler, R., Propagation of the virus of porcine epidemic diarrhea in cell culture (1988) J Clin Microbiol, 26, pp. 2235-2239; 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Sheahan, T., Whitmore, A., Long, K., Ferris, M., Rockx, B., Funkhouser, W., Donaldson, E., Baric, R.S., Successful vaccination strategies that protect aged mice from lethal challenge from influenza virus and heterologous severe acute respiratory syndrome coronavirus (2011) J Virol, 85, pp. 217-230. , https://doi.org/10.1128/JVI.01805-10; Huynh, J., Li, S., Yount, B., Smith, A., Sturges, L., Olsen, J.C., Nagel, J., Donaldson, E.F., Evidence supporting a zoonotic origin of human coronavirus strain NL63 (2012) J Virol, 86, pp. 12816-12825. , https://doi.org/10.1128/JVI.00906-12; Zaki, A.M., van Boheemen, S., Bestebroer, T.M., Osterhaus, A.D., Fouchier, R.A., Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia (2012) N Engl J Med, 367, pp. 1814-1820. , https://doi.org/10.1056/NEJMoa1211721","Baric, R.S.; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel HillUnited States; email: Rbaric@email.unc.edu",,American Society for Microbiology,0022538X,,JOVIA,31801868,English,J. Virol.,Article,Final,Open Access,Scopus,2-s2.0-85079471604,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Kumar S., Maurya V.K., Prasad A.K., Bhatt M.L.B., Saxena S.K.",57213855770;57202097349;57129828100;8954475700;7402626270;,"Structural, glycosylation and antigenic variation between 2019 novel coronavirus (2019-nCoV) and SARS coronavirus (SARS-CoV)",2020,VirusDisease,31,1,,13,21,,,10.1007/s13337-020-00571-5,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081588550&doi=10.1007%2fs13337-020-00571-5&partnerID=40&md5=8baa94ade0b4321dff765e075f2c1abd,"Department of Centre for Advanced Research (CFAR), Faculty of Medicine, King George’s Medical University (KGMU), Lucknow, 226003, India","Kumar, S., Department of Centre for Advanced Research (CFAR), Faculty of Medicine, King George’s Medical University (KGMU), Lucknow, 226003, India; Maurya, V.K., Department of Centre for Advanced Research (CFAR), Faculty of Medicine, King George’s Medical University (KGMU), Lucknow, 226003, India; Prasad, A.K., Department of Centre for Advanced Research (CFAR), Faculty of Medicine, King George’s Medical University (KGMU), Lucknow, 226003, India; Bhatt, M.L.B., Department of Centre for Advanced Research (CFAR), Faculty of Medicine, King George’s Medical University (KGMU), Lucknow, 226003, India; Saxena, S.K., Department of Centre for Advanced Research (CFAR), Faculty of Medicine, King George’s Medical University (KGMU), Lucknow, 226003, India","The emergence of 2019 novel coronavirus (2019-nCoV) is of global concern and might have emerged from RNA recombination among existing coronaviruses. CoV spike (S) protein which is crucial for receptor binding, membrane fusion via conformational changes, internalization of the virus, host tissue tropism and comprises crucial targets for vaccine development, remain largely uncharacterized. Therefore, the present study has been planned to determine the sequence variation, structural and antigenic divergence of S glycoprotein which may be helpful for the management of 2019-nCoV infection. The sequences of spike glycoprotein of 2019-nCoV and SARS coronavirus (SARS-CoV) were used for the comparison. The sequence variations were determined using EMBOSS Needle pairwise sequence alignment tools. The variation in glycosylation sites was predicted by NetNGlyc 1.0 and validated by N-GlyDE server. Antigenicity was predicted by NetCTL 1.2 and validated by IEDB Analysis Resource server. The structural divergence was determined by using SuperPose Version 1.0 based on cryo-EM structure of the SARS coronavirus spike glycoprotein. Our data suggests that 2019-nCoV is newly spilled coronavirus into humans in China is closely related to SARS-CoV, which has only 12.8% of difference with SARS-CoV in S protein and has 83.9% similarity in minimal receptor-binding domain with SARS-CoV. Addition of a novel glycosylation sites were observed in 2019-nCoV. In addition, antigenic analysis proposes that great antigenic differences exist between both the viral strains, but some of the epitopes were found to be similar between both the S proteins. In spite of the variation in S protein amino acid composition, we found no significant difference in their structures. Collectively, for the first time our results exhibit the emergence of human 2019-nCoV is closely related to predecessor SARS-CoV and provide the evidence that 2019-nCoV uses various novel glycosylation sites as SARS-CoV and may have a potential to become pandemic owing its antigenic discrepancy. Further, demonstration of novel Cytotoxic T lymphocyte epitopes may impart opportunities for the development of peptide based vaccine for the prevention of 2019-nCoV. © 2020, Indian Virological Society.",2019-nCoV; Antigenicity; Coronavirus; COVID-19; Glycosylation; S glycoprotein; SARS-CoV; Structural divergence,,"Cui, J., Li, F., Shi, Z.L., Origin and evolution of pathogenic Coronaviruses (2019) Nat Rev Microbiol, 17 (3), pp. 181-192. , COI: 1:CAS:528:DC%2BC1cXisVyhtbnL; Forni, D., Cagliani, R., Clerici, M., Sironi, M., Molecular evolution of human Coronavirus genomes (2017) Trends Microbiol, 25 (1), pp. 35-48. , COI: 1:CAS:528:DC%2BC28XhsFamtb%2FO; Fehr, A.R., Perlman, S., Coronaviruses: an overview of their replication and pathogenesis (2015) Methods Mol Biol, 1282, pp. 1-23. , COI: 1:CAS:528:DC%2BC28Xls12ksL8%3D; Narayanan, K., Ramirez, S.I., Lokugamage, K.G., Makino, S., Coronavirus nonstructural protein 1: common and distinct functions in the regulation of host and viral gene expression (2015) Virus Res, 202, pp. 89-100. , COI: 1:CAS:528:DC%2BC2cXitVWktr%2FN; 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Oostra, M., de Haan, C.A., Rottier, P.J., The 29-nucleotide deletion present in human but not in animal severe acute respiratory syndrome Coronaviruses disrupts the functional expression of open reading frame 8 (2007) J Virol, 81 (24), pp. 13876-13888. , COI: 1:CAS:528:DC%2BD2sXhsValsbfO; Parsons, L.M., Bouwman, K.M., Azurmendi, H., de Vries, R.P., Cipollo, J.F., Verheije, M.H., Glycosylation of the viral attachment protein of avian Coronavirus is essential for host cell and receptor binding (2019) J Biol Chem, 294 (19), pp. 7797-7809. , COI: 1:CAS:528:DC%2BC1MXhtVKlsbnI; Choy, W.Y., Lin, S.G., Chan, P.K., Tam, J.S., Lo, Y.M., Chu, I.M., Synthetic peptide studies on the severe acute respiratory syndrome (SARS) coronavirus spike glycoprotein: perspective for SARS vaccine development (2004) Clin Chem, 50 (6), pp. 1036-1042. , COI: 1:CAS:528:DC%2BD2cXltFOjs7g%3D","Saxena, S.K.; Department of Centre for Advanced Research (CFAR), Faculty of Medicine, King George’s Medical University (KGMU)India; email: shailen@kgmcindia.edu",,Springer,23473584,,,,English,VirusDisease,Article,Final,Open Access,Scopus,2-s2.0-85081588550,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Lai C.-C., Shih T.-P., Ko W.-C., Tang H.-J., Hsueh P.-R.",57214801883;57215200999;34570955800;7403124546;7103390478;,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges,2020,International Journal of Antimicrobial Agents,55,3,105924,,,,15,10.1016/j.ijantimicag.2020.105924,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080064519&doi=10.1016%2fj.ijantimicag.2020.105924&partnerID=40&md5=bb3f6cc0317f19ae076a02dac83e473c,"Department of Internal Medicine, Kaohsiung Veterans General Hospital, Tainan Branch, Tainan, Taiwan; Department of Family Medicine, Kaohsiung Veterans General Hospital, Tainan Branch, Tainan, Taiwan; Department of Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Medicine, Chi Mei Medical Center, 71004, Tainan, Taiwan; Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan","Lai, C.-C., Department of Internal Medicine, Kaohsiung Veterans General Hospital, Tainan Branch, Tainan, Taiwan; Shih, T.-P., Department of Family Medicine, Kaohsiung Veterans General Hospital, Tainan Branch, Tainan, Taiwan; Ko, W.-C., Department of Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Tang, H.-J., Department of Medicine, Chi Mei Medical Center, 71004, Tainan, Taiwan; Hsueh, P.-R., Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan, Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan","The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; previously provisionally named 2019 novel coronavirus or 2019-nCoV) disease (COVID-19) in China at the end of 2019 has caused a large global outbreak and is a major public health issue. As of 11 February 2020, data from the World Health Organization (WHO) have shown that more than 43 000 confirmed cases have been identified in 28 countries/regions, with >99% of cases being detected in China. On 30 January 2020, the WHO declared COVID-19 as the sixth public health emergency of international concern. SARS-CoV-2 is closely related to two bat-derived severe acute respiratory syndrome-like coronaviruses, bat-SL-CoVZC45 and bat-SL-CoVZXC21. It is spread by human-to-human transmission via droplets or direct contact, and infection has been estimated to have mean incubation period of 6.4 days and a basic reproduction number of 2.24–3.58. Among patients with pneumonia caused by SARS-CoV-2 (novel coronavirus pneumonia or Wuhan pneumonia), fever was the most common symptom, followed by cough. Bilateral lung involvement with ground-glass opacity was the most common finding from computed tomography images of the chest. The one case of SARS-CoV-2 pneumonia in the USA is responding well to remdesivir, which is now undergoing a clinical trial in China. Currently, controlling infection to prevent the spread of SARS-CoV-2 is the primary intervention being used. However, public health authorities should keep monitoring the situation closely, as the more we can learn about this novel virus and its associated outbreak, the better we can respond. © 2020 Elsevier Ltd",2019-nCoV; China; COVID-19; Epidemic; Remdesivir; SARS-CoV-2,"3CLpro inhibitor; alcohol; antibiotic agent; antifungal agent; antivirus agent; arbidol; benzalkonium chloride; Chinese drug; chlorhexidine gluconate; chloroquine; corticosteroid; disinfectant agent; ganciclovir; hydrogen peroxide; hypochlorite sodium; immunoglobulin; lamivudine; lianhua qingwen; lopinavir plus ritonavir; nucleoside analog; oseltamivir; peptide derivative; proteinase inhibitor; remdesivir; shufeng jiedu; sialidase inhibitor; steroid; tenofovir disoproxil; unclassified drug; acute heart failure; acute kidney failure; adult respiratory distress syndrome; antiviral activity; artificial ventilation; asymptomatic infection; basic reproduction number; China; clinical feature; computer assisted tomography; continuous renal replacement therapy; Coronavirinae; coronavirus disease 2019; Coronavirus infection; coughing; drug efficacy; drug response; epidemic; extracorporeal oxygenation; fever; human; hypoxemia; incidence; incubation time; infection control; infection prevention; intensive care unit; mixed infection; mortality; nonhuman; priority journal; Review; secondary infection; Severe acute respiratory syndrome coronavirus 2; shock; treatment outcome; virus inactivation; virus pneumonia; virus transmission; Betacoronavirus; Coronavirus infection; severe acute respiratory syndrome; virology; virus pneumonia; World Health Organization; Betacoronavirus; China; Coronavirus Infections; Disease Outbreaks; Humans; Pneumonia, Viral; Severe Acute Respiratory Syndrome; World Health Organization","Lu, H., Stratton, C.W., Tang, Y.W., Outbreak of pneumonia of unknown etiology in Wuhan China: the mystery and the miracle (2020) J Med Virol, , [Epub ahead of print]; Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med, , [Epub ahead of print]; Gorbalenya, A.E., Baker, S.C., Baric, R.S., de Groot, R.J., Drosten, C., Gulyaeva, A.A., Severe acute respiratory syndrome-related coronavirus: the species and its viruses—a statement of the Coronavirus Study Group (2020) bioRxiv; Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395, pp. 507-513; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506; Wang, C., Horby, P.W., Hayden, F.G., Gao, G.F., A novel coronavirus outbreak of global health concern (2020) Lancet, 395, pp. 470-473; Holshue, M.L., DeBolt, C., Lindquist, S., Lofy, K.H., Wiesman, J., Bruce, H., First case of 2019 novel coronavirus in the United States (2020) N Engl J Med, , [Epub ahead of print]; Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) JAMA, , [Epub ahead of print]; Chang, D., Lin, M., Wei, L., Xie, L., Zhu, G., Dela Cruz, C.S., Epidemiologic and clinical characteristics of novel coronavirus infections involving 13 patients outside Wuhan, China (2020) JAMA, , [Epub ahead of print]; Carlos, W.G., Dela Cruz, C.S., Cao, B., Pasnick, S., Jamil, S., Novel Wuhan (2019-nCoV) coronavirus (2020) Am J Respir Crit Care Med, 201, pp. P7-P8; Zhao, S., Lin, Q., Ran, J., Musa, S.S., Yang, G., Wang, W., Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: a data-driven analysis in the early phase of the outbreak (2020) Int J Infect Dis, 92, pp. 214-217; Biscayart, C., Angeleri, P., Lloveras, S., Chaves, T., Schlagenhauf, P., Rodriguez-Morales, A.J., The next big threat to global health? 2019 novel coronavirus (2019-nCoV): What advice can we give to travellers? — Interim recommendations January 2020, from the Latin-American Society for Travel Medicine (SLAMVI) (2020) Travel Med Infect Dis; Munster, V.J., Koopmans, M., van Doremalen, N., van Riel, D., de Wit, E., A novel coronavirus emerging in China—key questions for impact assessment (2020) N Engl J Med, , [Epub ahead of print]; Yoo, J.H., The fight against the 2019-nCoV outbreak: an arduous march has just begun (2020) J Korean Med Sci, 35, p. e56; Lee, K.H., Yoo, S.G., Cho, Y., Kwon, D.E., La, Y., Han, S.H., Characteristics of community-acquired respiratory viruses infections except seasonal influenza in transplant recipients and non-transplant critically ill patients (2019) J Microbiol Immunol Infect, , [Epub ahead of print]; Chou, C.C., Shen, C.F., Chen, S.J., Chen, H.M., Wang, Y.C., Chang, W.S., Recommendations and guidelines for the treatment of pneumonia in Taiwan (2019) J Microbiol Immunol Infect, 52, pp. 172-199; Lee, J.Y., Yang, P.C., Chang, C., Lin, I.T., Ko, W.C., Cia, C.T., Community-acquired adenoviral and pneumococcal pneumonia complicated by pulmonary aspergillosis in an immunocompetent adult (2019) J Microbiol Immunol Infect, 52, pp. 838-839; Su, I.C., Lee, K.L., Liu, H.Y., Chuang, H.C., Chen, L.Y., Lee, Y.J., Severe community-acquired pneumonia due to Pseudomonas aeruginosa coinfection in an influenza A(H1N1)pdm09 patient (2019) J Microbiol Immunol Infect, 52, pp. 365-366; Lee, S.H., Ruan, S.Y., Pan, S.C., Lee, T.F., Chien, J.Y., Hsueh, P.R., Performance of a multiplex PCR pneumonia panel for the identification of respiratory pathogens and the main determinants of resistance from the lower respiratory tract specimens of adult patients in intensive care units (2019) J Microbiol Immunol Infect, 52, pp. 920-928; Hung, H.M., Yang, S.L., Chen, C.J., Chiu, C.H., Kuo, C.Y., Huang, K.A., Molecular epidemiology and clinical features of rhinovirus infections among hospitalized patients in a medical center in Taiwan (2019) J Microbiol Immunol Infect, 52, pp. 233-241; Lin, G.L., Lu, C.Y., Chen, J.M., Lee, P.I., Ho, S.Y., Weng, K.C., Molecular epidemiology and clinical features of adenovirus infection in Taiwanese children, 2014 (2019) J Microbiol Immunol Infect, 52, pp. 215-224; Chan, J.F., Kok, K.H., Zhu, Z., Chu, H., To, K.K., Yuan, S., Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan (2020) Emerg Microbes Infect, 9, pp. 221-236; Lu, R., Zhao, X., Li, J., Niu, P., Yang, B., Wu, H., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet, , [Epub ahead of print]; Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, , [Epub ahead of print]; Jiang, S., Du, L., Shi, Z., An emerging coronavirus causing pneumonia outbreak in Wuhan, China: calling for developing therapeutic and prophylactic strategies (2020) Emerg Microbes Infect, 9, pp. 275-277; Ren, L.L., Wang, Y.M., Wu, Z.Q., Xiang, Z.C., Guo, L., Xu, T., Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study (2020) Chin Med J (Engl), , [Epub ahead of print]; Chen, L., Liu, W., Zhang, Q., Xu, K., Ye, G., Wu, W., RNA based mNGS approach identifies a novel human coronavirus from two individual pneumonia cases in 2019 Wuhan outbreak (2020) Emerg Microbes Infect, 9, pp. 313-319; 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Kanne, J.P., Chest CT findings in 2019 novel coronavirus (2019-nCoV) infections from Wuhan, China: key points for the radiologist (2020) Radiology, , [Epub ahead of print]; Song, F., Shi, N., Shan, F., Zhang, Z., Shen, J., Lu, H., Emerging coronavirus 2019-nCoV pneumonia (2020) Radiology, , [Epub ahead of print]; Lu, H., Drug treatment options for the 2019-new coronavirus (2019-nCoV) (2020) Biosci Trends, , [Epub ahead of print]; Wang, M., Cao, R., Zhang, L., Yang, X., Liu, J., Xu, M., Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro (2020) Cell Res, , [Epub ahead of print]; Liu, W., Morse, J.S., Lalonde, T., Xu, S., Learning from the past: possible urgent prevention and treatment options for severe acute respiratory infections caused by 2019-nCoV (2020) Chembiochem, , [Epub ahead of print]; Rolain, J.M., Colson, P., Raoult, D., Recycling of chloroquine and its hydroxyl analogue to face bacterial, fungal and viral infections in the 21st century (2007) Int J Antimicrob Agents, 30, pp. 297-308; Wang, W., Tang, J., Wei, F., Updated understanding of the outbreak of 2019 novel coronavirus (2019-nCoV) in Wuhan, China (2020) J Med Virol, , [Epub ahead of print]; Kim, J.Y., Choe, P.G., Oh, Y., Oh, K.J., Kim, J., Park, S.J., The first case of 2019 novel coronavirus pneumonia imported into Korea from Wuhan, China: implication for infection prevention and control measures (2020) J Korean Med Sci, 35, p. e61; World Health Organization, https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200207-sitrep-18-ncov.pdf?sfvrsn=fa644293_2, (WHO). Novel coronavirus (2019-nCoV). Situation report. [accessed 9 February 2020]; Patel, A., Jernigan, D.B., Initial public health response and interim clinical guidance for the 2019 novel coronavirus outbreak—United States, December 31, 2019–February 4, 2020 (2020) MMWR Morb Mortal Wkly Rep, 69, pp. 140-146; Casanova, L.M., Jeon, S., Rutala, W.A., Weber, D.J., Sobsey, M.D., Effects of air temperature and relative humidity on coronavirus survival on surfaces (2010) Appl Environ Microbiol, 76, pp. 2712-2717; Kampf, G., Todt, D., Pfaeder, S., Steinmann, E., Persistence of coronaviruses on inanimate surfaces and its inactivation with biocidal agents (2020) J Hosp Infect, , [Epub ahead of print]; Guan, W.J., Ni, Z.Y., Hu, Y., Laing, W.H., Ou, C.Q., He, J.X., Clinical characteristics of 2019 novel coronavirus infection in China (2020) medRxiv; Li, G., Fan, Y., Lai, Y., Han, T., Li, Z., Zhou, P., Coronavirus infections and immune responses (2020) J Med Virol, , [Epub ahead of print]; Russell, C.D., Millar, J.E., Baillie, J.K., Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury (2020) Lancet, 395, pp. 473-475","Hsueh, P.-R.; Departments of Laboratory Medicine and Internal Medicine, National Taiwan University Hospital, Number 7, Chung-Shan South Road, Taiwan; email: hsporen@ntu.edu.tw",,Elsevier B.V.,9248579,,IAAGE,32081636,English,Int. J. Antimicrob. Agents,Review,Final,Open Access,Scopus,2-s2.0-85080064519,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhang D.-H., Wu K.-L., Zhang X., Deng S.-Q., Peng B.",34973684800;57215186612;57215206375;57189065405;57208251294;,In silico screening of Chinese herbal medicines with the potential to directly inhibit 2019 novel coronavirus,2020,Journal of Integrative Medicine,18,2,,152,158,,2,10.1016/j.joim.2020.02.005,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080072709&doi=10.1016%2fj.joim.2020.02.005&partnerID=40&md5=5ea97c15c149f96862fed073a11969b5,"Shanghai Health Commission Key Lab of Artificial Intelligence (AI)-Based Management of Inflammation and Chronic Diseases, Sino-French Cooperative Central Lab, Shanghai Pudong Gongli Hospital, Secondary Military Medical University, Shanghai, 200135, China; Department of Traditional Chinese Medicine, Shanghai Pudong Gongli Hospital, Secondary Military Medical University, Shanghai, 200135, China; Department of Research Affair Management, Shanghai Pudong Gongli Hospital, Secondary Military Medical University, Shanghai, 200135, China","Zhang, D.-H., Shanghai Health Commission Key Lab of Artificial Intelligence (AI)-Based Management of Inflammation and Chronic Diseases, Sino-French Cooperative Central Lab, Shanghai Pudong Gongli Hospital, Secondary Military Medical University, Shanghai, 200135, China; Wu, K.-L., Department of Traditional Chinese Medicine, Shanghai Pudong Gongli Hospital, Secondary Military Medical University, Shanghai, 200135, China; Zhang, X., Shanghai Health Commission Key Lab of Artificial Intelligence (AI)-Based Management of Inflammation and Chronic Diseases, Sino-French Cooperative Central Lab, Shanghai Pudong Gongli Hospital, Secondary Military Medical University, Shanghai, 200135, China; Deng, S.-Q., Department of Research Affair Management, Shanghai Pudong Gongli Hospital, Secondary Military Medical University, Shanghai, 200135, China; Peng, B., Shanghai Health Commission Key Lab of Artificial Intelligence (AI)-Based Management of Inflammation and Chronic Diseases, Sino-French Cooperative Central Lab, Shanghai Pudong Gongli Hospital, Secondary Military Medical University, Shanghai, 200135, China","Objective: In this study we execute a rational screen to identify Chinese medical herbs that are commonly used in treating viral respiratory infections and also contain compounds that might directly inhibit 2019 novel coronavirus (2019-nCoV), an ongoing novel coronavirus that causes pneumonia. Methods: There were two main steps in the screening process. In the first step we conducted a literature search for natural compounds that had been biologically confirmed as against sever acute respiratory syndrome coronavirus or Middle East respiratory syndrome coronavirus. Resulting compounds were cross-checked for listing in the Traditional Chinese Medicine Systems Pharmacology Database. Compounds meeting both requirements were subjected to absorption, distribution, metabolism and excretion (ADME) evaluation to verify that oral administration would be effective. Next, a docking analysis was used to test whether the compound had the potential for direct 2019-nCoV protein interaction. In the second step we searched Chinese herbal databases to identify plants containing the selected compounds. Plants containing 2 or more of the compounds identified in our screen were then checked against the catalogue for classic herbal usage. Finally, network pharmacology analysis was used to predict the general in vivo effects of each selected herb. Results: Of the natural compounds screened, 13 that exist in traditional Chinese medicines were also found to have potential anti-2019-nCoV activity. Further, 125 Chinese herbs were found to contain 2 or more of these 13 compounds. Of these 125 herbs, 26 are classically catalogued as treating viral respiratory infections. Network pharmacology analysis predicted that the general in vivo roles of these 26 herbal plants were related to regulating viral infection, immune/inflammation reactions and hypoxia response. Conclusion: Chinese herbal treatments classically used for treating viral respiratory infection might contain direct anti-2019-nCoV compounds. © 2020 Shanghai Changhai Hospital",2019-nCoV; Chinese herbal; Drugs; Molecular docking; Natural compounds; Network pharmacology; Pneumonia; Wuhan coronavirus,herbaceous agent; 2019 novel coronavirus; antiviral activity; Article; Chinese medicine; computer model; Coronavirinae; Coronavirus infection; drug absorption; drug distribution; drug excretion; drug mechanism; drug metabolism; drug screening; drug targeting; human; hypoxia; in vivo study; inflammation; Middle East respiratory syndrome; Middle East respiratory syndrome coronavirus; molecular docking; nonhuman; priority journal; SARS coronavirus; severe acute respiratory syndrome,"Paraskevis, D., Kostaki, E.G., Magiorkinis, G., Panayiotakopoulos, G., Sourvinos, G., Tsiodras, S., Full-genome evolutionary analysis of the novel corona virus (2019-nCoV) rejects the hypothesis of emergence as a result of a recent recombination event (2020) Infect Genet Evol, 79; World Health Organization, (2005), https://www.who.int/news-room/detail/30-01-2020-statement-on-the-second-meeting-of-the-international-health-regulations–emergency-committee-regarding-the-outbreak-of-novel-coronavirus-(2019-ncov), Statement on the second meeting of the International Health Regulations Emergency Committee regarding the outbreak of novel coronavirus (2019-nCoV). (2020-01-30) [2020-02-02]; Chen, Z., Nakamura, T., Statistical evidence for the usefulness of Chinese medicine in the treatment of SARS (2004) Phytother Res, 18 (7), pp. 592-594; Lai, L., Han, X., Chen, H., Wei, P., Huang, C., Liu, S., Quaternary structure, substrate selectivity and inhibitor design for SARS 3C-like proteinase (2006) Cur Pharm Des, 12 (35), pp. 4555-4564; Wang, S.Q., Du, Q.S., Zhao, K., Li, A.X., Wei, D.Q., Chou, K.C., Virtual screening for finding natural inhibitor against cathepsin-L for SARS therapy (2007) Amino Acids, 33 (1), pp. 129-135; Kesel, A.J., Synthesis of novel test compounds for antiviral chemotherapy of severe acute respiratory syndrome (SARS) (2005) Curr Med Chem, 12 (18), pp. 2095-2162; Wu, C.Y., Jan, J.T., Ma, S.H., Kuo, C.J., Juan, H.F., Cheng, Y.S., Small molecules targeting severe acute respiratory syndrome human coronavirus (2004) Proc Natl Acad Sci U S A, 101 (27), pp. 10012-10017; Liu, B., Zhou, J., SARS-CoV protease inhibitors design using virtual screening method from natural products libraries (2005) J Comput Chem, 26 (5), pp. 484-490; Hoever, G., Baltina, L., Michaelis, M., Kondratenko, R., Baltina, L., Tolstikov, G.A., Antiviral activity of glycyrrhizic acid derivatives against SARS-coronavirus (2005) J Med Chem, 48 (4), pp. 1256-1259; Li, S.Y., Chen, C., Zhang, H.Q., Guo, H.Y., Wang, H., Wang, L., Identification of natural compounds with antiviral activities against SARS-associated coronavirus (2005) Antiviral Res, 67 (1), pp. 18-23; Chen, L., Li, J., Luo, C., Liu, H., Xu, W., Chen, G., Binding interaction of quercetin-3-β-galactoside and its synthetic derivatives with SARS-CoV 3CL(pro): structure-activity relationship studies reveal salient pharmacophore features (2006) Bioorg Med Chem, 14 (24), pp. 8295-8306; Park, J.Y., Yuk, H.J., Ryu, H.W., Lim, S.H., Kim, K.S., Park, K.H., Evaluation of polyphenols from Broussonetia papyrifera as coronavirus protease inhibitors (2017) J Enzyme Inhib Med Chem, 32 (1), pp. 504-515; Bhoj, V.G., Chen, Z.J., Ubiquitylation in innate and adaptive immunity (2009) Nature, 458 (7237), pp. 430-437; Isaacson, M.K., Ploegh, H.L., Ubiquitination, ubiquitin-like modifiers, and deubiquitination in viral infection (2009) Cell Host Microbe, 5 (6), pp. 559-570; Mukherjee, P., Shah, F., Desai, P., Avery, M., Inhibitors of SARS-3CLpro: virtual screening, biological evaluation, and molecular dynamics simulation studies (2011) J Chem Inf Model, 51 (6), pp. 1376-1392; Li, W., Moore, M.J., Vasilieva, N., Sui, J., Wong, S.K., Berne, M.A., Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus (2003) Nature, 426 (6965), pp. 450-454; Wen, C.C., Kuo, Y.H., Jan, J.T., Liang, P.H., Wang, S.Y., Liu, H.G., Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus (2007) J Med Chem, 50 (17), pp. 4087-4095; Ryu, Y.B., Park, S.J., Kim, Y.M., Lee, J.Y., Seo, W.D., Chang, J.S., SARS-CoV 3CLpro inhibitory effects of quinone-methide triterpenes from Tripterygium regelii (2010) Bioorg Med Chem Lett, 20 (6), pp. 1873-1876; Park, J.Y., Kim, J.H., Kim, Y.M., Jeong, H.J., Kim, D.W., Park, K.H., Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases (2012) Bioorg Med Chem, 20 (19), pp. 5928-5935; Park, J.Y., Kim, J.H., Kwon, J.M., Kwon, H.J., Jeong, H.J., Kim, Y.M., Dieckol, a SARS-CoV 3CL(pro) inhibitor, isolated from the edible brown algae Ecklonia cava (2013) Bioorg Med Chem, 21 (13), pp. 3730-3737; Song, Y.H., Kim, D.W., Curtis-Long, M.J., Yuk, H.J., Wang, Y., Zhuang, N., Papain-like protease (PLpro) inhibitory effects of cinnamic amides from Tribulus terrestris fruits (2014) Biol Pharm Bull, 37 (6), pp. 1021-1028; Park, J.Y., Ko, J.A., Kim, D.W., Kim, Y.M., Kwon, H.J., Jeong, H.J., Chalcones isolated from Angelica keiskei inhibit cysteine proteases of SARS-CoV (2016) J Enzyme Inhib Med Chem, 31 (1), pp. 23-30; Shen, L., Niu, J., Wang, C., Huang, B., Wang, W., Zhu, N., High-throughput screening and identification of potent broad-spectrum inhibitors of coronaviruses (2019) J Virol, 93 (12), pp. e00023-e119; Zhou, P., Yang, X.L., Wang, X.G., Hu, B., Zhang, L., Zhang, W., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature, , [Epub ahead of print]; Tian, H.Y., 2019-nCoV: new challenges from coronavirus (2020) Zhonghua Yu Fang Yi Xue Za Zhi, 54, p. E001. , [Chinese with abstract in English]; Hu, W., Fu, W., Wei, X., Yang, Y., Lu, C., Liu, Z., A network pharmacology study on the active ingredients and potential targets of Tripterygium wilfordii Hook for treatment of rheumatoid arthritis (2019) Evid Based Complement Alternat Med, 2019, p. 5276865; Rizvi, S.M., Shakil, S., Haneef, M., A simple click by click protocol to perform docking: AutoDock 4.2 made easy for non-bioinformaticians (2013) EXCLI J, 12, pp. 831-857; Kim, J.Y., Kim, Y.I., Park, S.J., Kim, I.K., Choi, Y.K., Kim, S.H., Safe, high-throughput screening of natural compounds of MERS-CoV entry inhibitors using a pseudovirus expressing MERS-CoV spike protein (2018) Int J Antimicrob Agents, 52 (5), pp. 730-732; Ratia, K., Saikatendu, K.S., Santarsiero, B.D., Barretto, N., Baker, S.C., Stevens, R.C., Severe acute respiratory syndrome coronavirus papain-like protease: structure of a viral deubiquitinating enzyme (2006) Proc Natl Acad Sci U S A, 103 (15), pp. 5717-5722; Anand, K., Ziebuhr, J., Wadhwani, P., Mesters, J.R., Hilgenfeld, R., Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs (2003) Science, 300 (5626), pp. 1763-1767; Xu, Y., Lou, Z., Liu, Y., Pang, H., Tien, P., Gao, G.F., Crystal structure of severe acute respiratory syndrome coronavirus spike protein fusion core (2004) J Biol Chem, 279 (47), pp. 49414-49419; Zhang, W., Huai, Y., Miao, Z., Qian, A., Wang, Y., Systems pharmacology for investigation of the mechanisms of action of traditional Chinese medicine in drug discovery (2019) Front Pharmacol, 10, p. 743","Zhang, D.-H.; Shanghai Health Commission Key Lab of Artificial Intelligence (AI)-Based Management of Inflammation and Chronic Diseases, Sino-French Cooperative Central Lab, Shanghai Pudong Gongli Hospital, Secondary Military Medical UniversityChina; email: shanghai_zhang@hotmail.com",,Elsevier (Singapore) Pte Ltd,20954964,,,32113846,English,J. Integr. Med.,Article,Final,Open Access,Scopus,2-s2.0-85080072709,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Tetro J.A.,6508339233;,Is COVID-19 receiving ADE from other coronaviruses?,2020,Microbes and Infection,22,2,,72,73,,2,10.1016/j.micinf.2020.02.006,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080070481&doi=10.1016%2fj.micinf.2020.02.006&partnerID=40&md5=f6e8144f574092359979a220c6ad1c76,"College of Biological Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada","Tetro, J.A., College of Biological Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada","One of the most perplexing questions regarding the current COVID-19 coronavirus epidemic is the discrepancy between the severity of cases observed in the Hubei province of China and those occurring elsewhere in the world. One possible answer is antibody dependent enhancement (ADE) of SARS-CoV-2 due to prior exposure to other coronaviruses. ADE modulates the immune response and can elicit sustained inflammation, lymphopenia, and/or cytokine storm, one or all of which have been documented in severe cases and deaths. ADE also requires prior exposure to similar antigenic epitopes, presumably circulating in local viruses, making it a possible explanation for the observed geographic limitation of severe cases and deaths. © 2020 Institut Pasteur",Antibody dependent enhancement; Coronavirus; COVID-19,"epitope; COVID-19; severe acute respiratory syndrome coronavirus 2; 2019 novel coronavirus; adult respiratory distress syndrome; antibody dependent enhancement; Article; Coronavirinae; Coronavirus infection; cytokine storm; epidemic; immune response; priority journal; SARS coronavirus; seroconversion; seroprevalence; Betacoronavirus; China; epidemiology; human; immunology; medical geography; mortality; pandemic; pathogenicity; pathology; virus pneumonia; Antibody-Dependent Enhancement; Betacoronavirus; China; Coronavirus Infections; Geography, Medical; Humans; Pandemics; Pneumonia, Viral","Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395 (10223), pp. 507-513. , pii: S0140-6736(20)30211-7; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395 (10223), pp. 497-506. , pii: S0140-6736(20)30183-5; Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China (2020) J Am Med Assoc; Cheung, C.Y., Poon, L.L.M., Ng, I.H.Y., Luk, W., Sia, S.-F., Wu, M.H.S., Cytokine responses in severe acute respiratory syndrome coronavirus-infected macrophages in vitro: possible relevance to pathogenesis (2005) J Virol, 79, pp. 7819-7826; New coronavirus may be no more dangerous than the flu despite worldwide alarm: experts (2020) Natl Post, , https://nationalpost.com/health/new-coronavirus-may-be-no-more-dangerous-than-the-flu-despite-worldwide-alarm-experts, [Internet] [cited 2020 Feb 9]. Available from:; Yang, Z.Y., Werner, H.C., Kong, W.P., Leung, K., Traggiai, E., Lanzavecchia, A., Evasion of antibody neutralization in emerging severe acute respiratory syndrome coronaviruses (2005) Proc Natl Acad Sci U S A, 102, pp. 797-801; Ho, M.S., Chen, W.J., Chen, H.Y., Lin, S.F., Wang, W.C., Di, J., Neutralizing antibody response and SARS severity (2005) Emerg Infect Dis, 11, pp. 1730-1737; Yip, M.S., Leung, N.H., Cheung, C.Y., Li, P.H., Lee, H.H.Y., Daëron, M., Antibody-dependent infection of human macrophages by severe acute respiratory syndrome coronavirus (2014) Virol J, 11, p. 82; Jaume, M., Yip, M.S., Cheung, C.Y., Leung, H.L., Li, P.H., Kien, F., Anti-severe acute respiratory syndrome coronavirus spike antibodies trigger infection of human immune cells via a pH- and cysteine protease-independent FcγR pathway (2011) J Virol, 85, pp. 10582-10597; Wang, S.F., Tseng, S.P., Yen, C.H., Yang, J.Y., Tsao, C.H., Shen, C.W., Antibody-dependent SARS coronavirus infection is mediated by antibodies against spike proteins (2014) Biochem Biophys Res Commun, 451, pp. 208-214; Yoshikawa, T., Hill, T., Li, K., Peters, C.J., Tseng, C.-T.K., Severe acute respiratory syndrome (SARS) coronavirus-induced lung epithelial cytokines exacerbate SARS pathogenesis by modulating intrinsic functions of monocyte-derived macrophages and dendritic cells (2009) J Virol, 83, pp. 3039-3048; Channappanavar, R., Fehr, A.R., Vijay, R., Mack, M., Zhao, J., Meyerholz, D.K., Dysregulated type I interferon and inflammatory monocyte-macrophage responses cause lethal pneumonia in SARS-CoV-infected mice (2016) Cell Host Microbe, 19, pp. 181-193; Donnelly, C.A., Fisher, M.C., Fraser, C., Ghani, A.C., Riley, S., Ferguson, N.M., Epidemiological and genetic analysis of severe acute respiratory syndrome (2004) Lancet Infect Dis, 4, pp. 672-683; Gorbalenya, A.E., Severe acute respiratory syndrome-related coronavirus – the species and its viruses, a statement of the Coronavirus Study Group (2020) BioRxiv; Lu, R., Zhao, X., Li, J., Niu, P., Yang, B., Wu, H., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet, (20), pp. 30251-30258. , pii: S0140-6736; Hua, R., Zhou, Y., Wang, Y., Hua, Y., Tong, G., Identification of two antigenic epitopes on SARS-CoV spike protein (2004) Biochem Biophys Res Commun, 319, pp. 929-935; Leung, G.M., Lim, W.W., Ho, L.M., Lam, T.H., Ghani, A.C., Donnelly, C.A., Seroprevalence of IgG antibodies to SARS-coronavirus in asymptomatic or subclinical population groups (2006) Epidemiol Infect, 134, pp. 211-221; Wu, Z., Yang, L., Ren, X., He, G., Zhang, J., Yang, J., Deciphering the bat virome catalog to better understand the ecological diversity of bat viruses and the bat origin of emerging infectious diseases (2016) ISME J, 10, pp. 609-620",,,Elsevier Masson SAS,12864579,,MCINF,32092539,English,Microbes Infect.,Article,Final,Open Access,Scopus,2-s2.0-85080070481,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Tsai Y.-C., Lee C.-L., Yen H.-R., Chang Y.-S., Lin Y.-P., Huang S.-H., Lin C.-W.",57211111209;56012577500;7102476689;57211591490;57211112871;7405421039;35269379500;,Antiviral action of tryptanthrin isolated from strobilanthes cusia leaf against human coronavirus nl63,2020,Biomolecules,10,3,366,,,,,10.3390/biom10030366,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081012604&doi=10.3390%2fbiom10030366&partnerID=40&md5=6ff32adb79602e6c0f069c18d8562e01,"College of Health Care, China Medical University, Taichung, 40402, Taiwan; Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung, 40402, Taiwan; Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, 40402, Taiwan; Department of Cosmeceutics, China Medical University, Taichung, 40402, Taiwan; Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung, 40447, Taiwan; Chinese Medicine Research Center, China Medical University, Taichung, 40402, Taiwan; Graduate Institute of Chinese Medicine, School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, 40402, Taiwan; Department of Chinese Medicine, China Medical University Hospital, Taichung, 40447, Taiwan; Research Center for Traditional Chinese Medicine, Department of Medical Research, China Medical University Hospital, Taichung, 40447, Taiwan; Department of Biotechnology, Asia University, Wufeng, Taichung 41354, Taiwan","Tsai, Y.-C., College of Health Care, China Medical University, Taichung, 40402, Taiwan, Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung, 40402, Taiwan, Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, 40402, Taiwan; Lee, C.-L., Department of Cosmeceutics, China Medical University, Taichung, 40402, Taiwan, Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung, 40447, Taiwan, Chinese Medicine Research Center, China Medical University, Taichung, 40402, Taiwan; Yen, H.-R., Chinese Medicine Research Center, China Medical University, Taichung, 40402, Taiwan, Graduate Institute of Chinese Medicine, School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, 40402, Taiwan, Department of Chinese Medicine, China Medical University Hospital, Taichung, 40447, Taiwan, Research Center for Traditional Chinese Medicine, Department of Medical Research, China Medical University Hospital, Taichung, 40447, Taiwan; Chang, Y.-S., Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung, 40402, Taiwan, Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, 40402, Taiwan; Lin, Y.-P., Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, 40402, Taiwan; Huang, S.-H., Department of Biotechnology, Asia University, Wufeng, Taichung 41354, Taiwan; Lin, C.-W., College of Health Care, China Medical University, Taichung, 40402, Taiwan, Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung, 40402, Taiwan, Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, 40402, Taiwan, Chinese Medicine Research Center, China Medical University, Taichung, 40402, Taiwan, Department of Biotechnology, Asia University, Wufeng, Taichung 41354, Taiwan","Strobilanthes cusia (Nees) Kuntze is a Chinese herbal medicine used in the treatment of respiratory virus infections. The methanol extract of S. cusia leaf contains chemical components such as β-sitosterol, indirubin, tryptanthrin, betulin, indigodole A, and indigodole B that have diverse biological activities. However, the antiviral action of S. cusia leaf and its components against human coronavirus remains to be elucidated. Human coronavirus NL63 infection is frequent among immunocompromised individuals, young children, and in the elderly. This study investigated the anti-Human coronavirus NL63 (HCoV-NL63) activity of the methanol extract of S. cusia leaf and its major components. The methanol extract of S. cusia leaf effectively inhibited the cytopathic effect (CPE) and virus yield (IC50 = 0.64 µg/mL) in HCoV-NL63-infected cells. Moreover, this extract potently inhibited the HCoV-NL63 infection in a concentration-dependent manner. Among the six components identified in the methanol extract of S. cusia leaf, tryptanthrin and indigodole B (5aR-ethyltryptanthrin) exhibited potent antiviral activity in reducing the CPE and progeny virus production. The IC50 values against virus yield were 1.52 µM and 2.60 µM for tryptanthrin and indigodole B, respectively. Different modes of time-of-addition/removal assay indicated that tryptanthrin prevented the early and late stages of HCoV-NL63 replication, particularly by blocking viral RNA genome synthesis and papain-like protease 2 activity. Notably, tryptanthrin (IC50 = 0.06 µM) and indigodole B (IC50 = 2.09 µM) exhibited strong virucidal activity as well. This study identified tryptanthrin as the key active component of S. cusia leaf methanol extract that acted against HCoV-NL63 in a cell-type independent manner. The results specify that tryptanthrin possesses antiviral potential against HCoV-NL63 infection. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.",,5aR ethyltryptanthrin; alkaloid; antivirus agent; betulin; indigodole A; indirubin; papain like protease 2; plant extract; proteinase; sitosterol; Strobilanthes cusia extract; tryptanthrin; unclassified drug; Acanthaceae; animal cell; antiviral activity; Calu-3 cell line; cell viability; controlled study; cytopathogenic effect; cytotoxicity; dot hybridization; fluorescence microscopy; gene expression; gene synthesis; human; human cell; Human coronavirus NL63; IC50; immunofluorescence test; in vitro study; LLC-MK2 cell line; MTT assay; nonhuman; nuclear magnetic resonance spectroscopy; nucleotide sequence; protein cleavage; protein purification; real time reverse transcription polymerase chain reaction; Review; size exclusion chromatography; Strobilanthes cusia; viral plaque assay; virostatic activity; virucidal activity; virus infectivity; virus inhibition; virus load; virus replication; Western blotting,"Lin, W., Huang, W., Ning, S., Wang, X., Ye, Q., Wei, D., De novo characterization of the Baphicacanthus cusia(Nees) Bremek transcriptome and analysis of candidate genes involved in indican biosynthesis and metabolism (2018) Plos ONE, 13; Chen, H., Shao, J., Zhang, H., Jiang, M., Huang, L., Zhang, Z., Yang, D., Luo, X., Sequencing and Analysis of Strobilanthes cusia (Nees) Kuntze Chloroplast Genome Revealed the Rare Simultaneous Contraction and Expansion of the Inverted Repeat Region in Angiosperm (2018) Front. 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Ethnomed., 10, p. 23; Lee, C.L., Wang, C.M., Hu, H.C., Yen, H.R., Song, Y.C., Yu, S.J., Chen, C.J., Wu, Y.C., Indole alkaloids indigodoles A–C from aerial parts of Strobilanthes cusia in the traditional Chinese medicine Qing Dai have anti-IL-17 properties (2019) Phytochemistry, 162, pp. 39-46; Liau, B.C., Jong, T.T., Lee, M.R., Chen, S.S., LC-APCI-MS method for detection and analysis of tryptanthrin, indigo, and indirubin in daqingye and banlangen (2007) J. Pharm. Biomed. Anal., 43, pp. 346-351; Chang, S.J., Chang, Y.C., Lu, K.Z., Tsou, Y.Y., Lin, C.W., Antiviral Activity of Isatis indigotica Extract and Its Derived Indirubin against Japanese Encephalitis Virus (2012) Evid. Based. Complement. Alternat. Med., 2012; Hu, Z., Tu, Y., Xia, Y., Cheng, P., Sun, W., Shi, Y., Guo, L., Chen, S., Identification and Verification of Indirubin-Containing Medicinal Plants (2015) Evid. Based. Complement. Alternat. Med., 2015; Lai, J.L., Liu, Y.H., Liu, C., Qi, M.P., Liu, R.N., Zhu, X.F., Zhou, Q.G., Guo, A.Z., Hu, C.M. Indirubin Inhibits LPS-Induced Inflammation via TLR4 Abrogation Mediated by the NF-kB and MAPK Signaling Pathways (2017) Inflammation, 40, pp. 1-12; Mak, N.K., Leung, C.Y., Wei, X.Y., Shen, X.L., Wong, R.N., Leung, K.N., Fung, M.C., Inhibition of RANTES expression by indirubin in influenza virus-infected human bronchial epithelial cells (2004) Biochem. Pharmacol., 67, pp. 167-174; Lin, C.W., Tsai, F.J., Tsai, C.H., Lai, C.C., Wan, L., Ho, T.Y., Hsieh, C.C., Chao, P.D., Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds (2005) Antivir. Res., 68, pp. 36-42; Li, S.W., Lin, C.W., Human coronaviruses: Clinical features and phylogenetic analysis (2013) Biomedicine (Taipei), 3, pp. 43-50; Milewska, A., Nowak, P., Owczarek, K., Szczepanski, A., Zarebski, M., Hoang, A., Berniak, K., Baster, Z., Entry of Human Coronavirus NL63 into the (2018) Cell. J. Virol., 92; van der Hoek, L., Pyrc, K., Berkhout, B., Human coronavirus NL63, a new respiratory virus (2006) FEMS Microbiol. Rev., 30, pp. 760-773; Letko, M., Marzi, A., Munster, V., Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses (2020) Nat. Microbiol., , in press. [CrossRef; Huang, S.H., Su, M.C., Tien, N., Huang, C.J., Lan, Y.C., Lin, C.S., Chen, C.H., Lin, C.W., Epidemiology of human coronavirus NL63 infection among hospitalized patients with pneumonia in Taiwan (2017) J. Microbiol. Immunol. Infect., 50, pp. 763-770; Su, J.H., Diao, R.G., Lv, S.G., Mou, X.D., Li (2016) K. Modes of Antiviral Action of Chemical Portions and Constituents from Woad Root Extract against Influenza Virus a FM1. Evid. Based Complement. Alternat. Med, p. 2016; Hand, J., Rose, E.B., Salinas, A., Lu, X., Sakthivel, S.K., Schneider, E., Watson, J.T., Severe Respiratory Illness Outbreak Associated with Human Coronavirus NL63 in a Long-Term Care Facility (2018) Emerg. Infect. Dis., 24, pp. 1964-1966; Beau De Rochars, V.M., Lednicky, J., White, S., Loeb, J., Elbadry, M.A., Telisma, T., Chavannes, S., Ciccozzi, M., Isolation of Coronavirus NL63 from Blood from Children in Rural Haiti: Phylogenetic Similarities with Recent Isolates from Malaysia (2017) Am. J. Trop. Med. Hyg., 96, pp. 144-147; Lednicky, J.A., Waltzek, T.B., McGeehan, E., Loeb, J.C., Hamilton, S.B., Luetke, M.C., Isolation and genetic characterization of human coronavirus NL63 in primary human renal proximal tubular epithelial cells obtained from a commercial supplier, and confirmation of its replication in two different types of human primary kidney cells (2013) Virol. J., 10; Shankar, G.M., Alex, V.V., Nisthul, A.A., Bava, S.V., Sundaram, S., Retnakumari, A.P., Chittalakkottu, S., Anto, R.J., Pre-Clinical Evidences for the Efficacy of Tryptanthrin as a Potent Suppressor of Skin Cancer; Han, N.R., Kim, H.M., Jeong, H.J., Tryptanthrin reduces mast cell proliferation promoted by TSLP through modulation of MDM2 and p53 (2016) Biomed. Pharmacother., 79, pp. 71-87; Honda, G., Tabata, M., Isolation of antifungal principle tryptanthrin, from Strobilanthes cusia O. Kuntze (1979) Planta Med, 36, pp. 85-90; Honda, G., Tosirisuk, V., Tabata, M., Isolation of an antidermatophytic, tryptanthrin, from indigo plants, Polygonum tinctorium and Isatis tinctoria (1980) Planta Med, 38, pp. 275-276; Plitzko, I., Mohn, T., Sedlacek, N., Hamburger, M., Composition of Indigo naturalis (2009) Planta Med, 75, pp. 860-863; Kataoka, M., Hirata, K., Kunikata, T., Ushio, S., Iwaki, K., Ohashi, K., Ikeda, M., Kurimoto, M., Antibacterial action of tryptanthrin and kaempferol, isolated from the indigo plant (Polygonum tinctorium Lour.), against Helicobacter pylori-infected Mongolian gerbils (2001) J. Gastroenterol., 36, pp. 5-9; Ishihara, T., Kohno, K., Ushio, S., Iwaki, K., Ikeda, M., Kurimoto, M., Tryptanthrin inhibits nitric oxide and prostaglandin E(2) synthesis by murine macrophages (2000) Eur. J. Pharmacol., 407, pp. 197-204; Recio, M.C., Cerdá-Nicolás, M., Potterat, O., Hamburger, M., Ríos, J.L., Anti-inflammatory and antiallergic activity in vivo of lipophilic Isatis tinctoria extracts and tryptanthrin (2006) Planta Med, 72, pp. 539-546; Kimoto, T., Hino, K., Koya-Miyata, S., Yamamoto, Y., Takeuchi, M., Nishizaki, Y., Micallef, M.J., Ikeda, M., Cell differentiation and apoptosis of monocytic and promyelocytic leukemia cells (U-937 and HL-60) by tryptanthrin, an active ingredient of Polygonum tinctorium Lour (2001) Pathol. Int., 51, pp. 315-325; Miao, S., Shi, X., Zhang, H., Wang, S., Sun, J., Hua, W., Miao, Q., Zhang, C., Proliferation-attenuating and apoptosis-inducing effects of tryptanthrin on human chronic myeloid leukemia K562 cell line in vitro (2011) Int. J. Mol. Sci., 12, pp. 3831-3845; Yu, S.T., Chen, T.M., Chern, J.W., Tseng, S.Y., Chen, Y.H., Downregulation of GSTpi expression by tryptanthrin contributing to sensitization of doxorubicin-resistant MCF-7 cells through C-Jun NH2-terminal kinase-mediated apoptosis (2009) Anticancer Drugs, 20, pp. 382-388; Zhu, X., Zhang, X., Ma, G., Yan, J., Wang, H., Yang, Q., Transport characteristics of tryptanthrin and its inhibitory effect on P-gp and MRP2 in Caco-2 cells (2011) J. Pharm. Pharm. Sci., 14, pp. 325-335; Chang, H.N., Yeh, Y.C., Chueh, H.Y., Pang, J.S., The anti-angiogenic effect of tryptanthrin is mediated by the inhibition of apelin promoter activity and shortened mRNA half-life in human vascular endothelial cells (2019) Phytomedicine, 58; Lee, S., Kim, D.C., Baek, H.Y., Lee, K.D., Kim, Y.C., Oh, H., Anti-neuroinflammatory effects of tryptanthrin from Polygonum tinctorium Lour. In lipopolysaccharide-stimulated BV2 microglial cells (2018) Arch. Pharm. Res., 41, pp. 419-430; Jung, E.H., Jung, J.Y., Ko, H.L., Kim, J.K., Park, S.M., Jung, D.H., Park, C.A., Cho, I.J., Tryptanthrin prevents oxidative stress-mediated apoptosis through AMP-activated protein kinase-dependent p38 mitogen-activated protein kinase activation (2017) Arch. Pharm. Res., 40, pp. 1071-1086; Yang, Z., Wang, Y., Zheng, Z., Zhao, S., Zhao, J., Lin, Q., Li, C., Zhong, N., Antiviral activity of Isatis indigotica root-derived clemastanin B against human and avian influenza A and B viruses in vitro (2013) Int. J. Mol. Med., 31, pp. 867-873; Su, S., Wong, G., Shi, W., Liu, J., Lai, A.C.K., Zhou, J., Liu, W., Gao, G.F., Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses (2016) Trends Microbiol, 24, pp. 490-502; Gao, B., Zhang, J., Xie, L., Structure Analysis of Effective Chemical Compounds against Dengue Viruses Isolated from Isatis tinctoria (2018) Can. J. Infect. Dis. Med. Microbiol., 2018; Hsuan, S.L., Chang, S.C., Wang, S.Y., Liao, T.L., Jong, T.T., Chien, M.S., Lee, W.C., Liao, J.W., The cytotoxicity to leukemia cells and antiviral effects of Isatis indigotica extracts on pseudorabies virus (2009) J. Ethnopharmacol., 123, pp. 61-67","Lin, C.-W.; College of Health Care, China Medical UniversityTaiwan; email: cwlin@mail.cmu.edu.tw",,MDPI AG,2218273X,,,32120929,English,Biomolecules,Review,Final,Open Access,Scopus,2-s2.0-85081012604,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Goodrich E.L., Mittel L.D., Glaser A., Ness S.L., Radcliffe R.M., Divers T.J.",57204042901;6505963830;7102051789;55228493900;7007177797;8585911600;,Novel findings from a beta coronavirus outbreak on an American Miniature Horse breeding farm in upstate New York,2020,Equine Veterinary Education,32,3,,150,154,,2,10.1111/eve.12938,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85047529263&doi=10.1111%2feve.12938&partnerID=40&md5=d2f5a65e8bb5e13a9d0fec761555ed3e,"Department of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center, College of Veterinary Medicine, Cornell University, Ithaca, NY, United States; Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, United States","Goodrich, E.L., Department of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center, College of Veterinary Medicine, Cornell University, Ithaca, NY, United States; Mittel, L.D., Department of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center, College of Veterinary Medicine, Cornell University, Ithaca, NY, United States; Glaser, A., Department of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center, College of Veterinary Medicine, Cornell University, Ithaca, NY, United States; Ness, S.L., Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, United States; Radcliffe, R.M., Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, United States; Divers, T.J., Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, United States","This case report describes an outbreak and novel findings associated with a beta coronavirus (BCoV) infection that occurred on an American Miniature Horse (AMH) breeding farm in upstate New York, in January and February of 2013. Twenty-nine AMH and one donkey were present on the farm when the outbreak occurred. One 10-year-old Quarter Horse mare, stabled at a separate location and owned by an employee of the farm, also tested positive. A polymerase chain reaction (PCR) assay for the detection of BCoV was performed at the Animal Health Diagnostic Center (AHDC) at Cornell on all faecal samples. The PCR assay used detects multiple beta coronaviruses, including, but not limited to, equine enteric coronavirus (ECoV). Novel findings regarding this BCoV infection in horses were recognised in this outbreak study. To the authors’ knowledge, this is the largest outbreak of BCoV described thus far in a closed herd on a single premise. The case fatality rate was 0% unlike that described in a previous outbreak of ECoV involving miniature horses and a miniature donkey (Fielding et al. 2015). The morbidity rate was lower in this outbreak than in previously described studies (Oue et al. 2013; Pusterla et al. 2013). This outbreak also demonstrated the potential for BCoV transmission via farm personnel. The duration of shedding of virus in the faeces among some asymptomatic horses in this outbreak was longer than previously described clinical cases of ECoV (Pusterla et al. 2013; Nemoto et al. 2014). This study suggests that asymptomatic animals may play a role in the maintenance of BCoV during an outbreak; therefore, the need for diagnostic testing of both clinically affected and apparently clinically normal horses on a premises followed by appropriate biosecurity and control measures. © 2018 EVJ Ltd",American Miniature Horse; beta coronavirus; clinical signs; diagnosis; horse,cotrimoxazole; flunixin meglumine; infusion fluid; nucleocapsid protein; omeprazole; oxytetracycline; pentoxifylline; animal experiment; animal lameness; Article; Betacoronavirus; blood analysis; body constitution; colic; controlled study; Coronavirus infection; dehydration; diarrhea; epidemic; equine herpesvirus 2; feces analysis; female; fever; follow up; gene sequence; hematocrit; horse; horse disease; hospitalization; hypertransaminasemia; hypochloremia; hyponatremia; jaundice; lethargy; leukopenia; lymphocytopenia; neutropenia; nonhuman; polymerase chain reaction; Strongyloidea; tachycardia; virus isolation,"Davis, E., Rush, B.R., Cox, J., DeBey, B., Kapil, S., Neonatal enterocolitis associated with coronavirus infection in a foal: a case report (2000) J. Vet. Diagn. Invest., 12, pp. 153-156; Fielding, C.L., Higgins, J.K., Higgins, J.C., McIntosh, S., Scott, E., Giannitti, F., Pusterla, N., Disease associated with equine coronavirus infection and high case fatality rate (2015) J. Vet. Intern. Med., 29, pp. 307-310; Giannitti, F., Diab, S., Mete, A., Stanton, J.B., Fielding, L., Crossley, B., Sverlow, K., Pusterla, N., Necrotizing enteritis and hyperammonemic encephalopathy associated with equine coronavirus infection in equids (2015) Vet. Pathol., 52, pp. 1148-1156; Hemida, M.G., Chu, D.K.W., Perera, R.A.P.M., Ko, R.L.W., So, R.T.Y., Ng, B.C.Y., Chan, S.M.S., Peiris, M., Coronavirus infections in horses in Saudi Arabia and Oman (2017) Transbound Emerg. Dis., 64, pp. 2093-2103; Kooijman, L.J., Mapes, S.M., Pusterla, N., Development of an equine coronavirus-specific enzyme-linked immunosorbent assay to determine serologic responses in naturally infected horses (2016) J. Vet. Diagn. Invest., 28, pp. 414-418; Miszczak, F., Tesson, V., Kin, N., Dina, J., Balasuriya, U.B.R., Pronost, S., Vabret, A., First detection of equine coronavirus (BCoV) in Europe (2014) Vet. Microbiol., 171, pp. 206-209; Nemoto, M., Oue, Y., Morita, Y., Kanno, T., Kinoshita, Y., Niwa, H., Ueno, T., Kondo, T., Experimental inoculation of equine coronavirus into Japanese draft horses (2014) Arch. Virol., 159, pp. 3329-3334; Oue, Y., Ishihara, R., Edamatsu, H., Morita, Y., Yoshida, M., Yoshima, M., Hatama, S., Kanno, T., Isolation of an equine coronavirus from adult horses with pyrogenic and enteric disease and its antigenic and genomic characterization in comparison with the NC99 strain (2011) Vet. Microbiol., 150, pp. 41-48; Oue, Y., Morita, Y., Kondo, T., Nemoto, M., Epidemic of equine coronavirus at Obihiro Racecourse, Hokkaido, Japan in 2012 (2013) J. Vet. Med. Sci., 75, pp. 1261-1265; Pusterla, N., Mapes, S., Wademan, C., White, A., Ball, R., Sapp, K., Burns, P., Magdesian, K.G., Emerging outbreaks associated with equine coronavirus in adult horses (2013) Vet. Microbiol., 162, pp. 228-231; Pusterla, N., Holzenkaempfer, N., Mapes, S., Kass, P., Prevalence of equine coronavirus in nasal secretions from horses with fever and upper respiratory tract infection (2015) Vet. Rec., 177, p. 289; Slovis, N.M., Elam, J., Estrada, M., Leutenegger, C.M., Infectious agents associated with diarrhea in neonatal foals in central Kentucky: a comprehensive molecular study (2014) Equine Vet. J., 46, pp. 311-316","Goodrich, E.L.; Department of Population Medicine and Diagnostic Sciences, Animal Health Diagnostic Center, College of Veterinary Medicine, Cornell UniversityUnited States; email: elg25@cornell.edu",,Equine Veterinary Journal Ltd,9577734,,,,English,Equine Vet. Educ.,Article,Final,Open Access,Scopus,2-s2.0-85047529263,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhou Z., Sun Y., Yan X., Tang X., Li Q., Tan Y., Lan T., Ma J.",57200414689;56166199400;57208907179;57196185375;57208317097;57211109902;57201787210;57205222918;,Swine acute diarrhea syndrome coronavirus (SADS-CoV) antagonizes interferon-β production via blocking IPS-1 and RIG-I,2020,Virus Research,278,,197843,,,,,10.1016/j.virusres.2019.197843,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077648500&doi=10.1016%2fj.virusres.2019.197843&partnerID=40&md5=f6a41969d4db583bd234810864bb16e3,"College of Animal Science, South China Agricultural University, Guangzhou, China; Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangzhou, Guangdong, China","Zhou, Z., College of Animal Science, South China Agricultural University, Guangzhou, China, Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangzhou, Guangdong, China; Sun, Y., College of Animal Science, South China Agricultural University, Guangzhou, China, Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangzhou, Guangdong, China; Yan, X., College of Animal Science, South China Agricultural University, Guangzhou, China, Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangzhou, Guangdong, China; Tang, X., College of Animal Science, South China Agricultural University, Guangzhou, China, Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangzhou, Guangdong, China; Li, Q., College of Animal Science, South China Agricultural University, Guangzhou, China, Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangzhou, Guangdong, China; Tan, Y., College of Animal Science, South China Agricultural University, Guangzhou, China, Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangzhou, Guangdong, China; Lan, T., College of Animal Science, South China Agricultural University, Guangzhou, China, Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangzhou, Guangdong, China; Ma, J., College of Animal Science, South China Agricultural University, Guangzhou, China, Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangzhou, Guangdong, China","Swine acute diarrhea syndrome coronavirus (SADS-CoV), a newly emerging enteric coronavirus, is considered to be associated with swine acute diarrhea syndrome (SADS) which has caused significantly economic losses to the porcine industry. Interactions between SADS-CoV and the host innate immune response is unclear yet. In this study, we used IPEC-J2 cells as a model to explore potential evasion strategies employed by SADS-CoV. Our results showed that SADS-CoV infection failed to induce IFN-β production, and inhibited poly (I:C) and Sendai virus (SeV)-triggered IFN-β expression. SADS-CoV also blocked poly (I:C)-induced phosphorylation and nuclear translocation of IRF-3 and NF-κB. Furthermore, SADS-CoV did not interfere with the activity of IFN-β promoter stimulated by IRF3, TBK1 and IKKε, but counteracted its activation induced by IPS-1 and RIG-I. Collectively, this study is the first investigation that shows interactions between SADS-CoV and the host innate immunity, which provides information of the molecular mechanisms underlying SASD-CoV infection. © 2019",Interferon beta; IPS-1; RIG-I; Swine acute diarrhea syndrome coronavirus,adaptor protein; beta interferon; I kappa B kinase epsilon; immunoglobulin enhancer binding protein; interferon regulatory factor 3; mitochondrial antiviral signaling protein; polyinosinic polycytidylic acid; protein IPS 1; retinoic acid inducible protein I; unclassified drug; acute diarrhea; animal cell; Article; cell nucleus; cell proliferation; controlled study; Coronavirinae; innate immunity; interferon production; IPEC-J2 cell line; molecular biology; nonhuman; priority journal; promoter region; protein expression; protein phosphorylation; protein transport; Sendai virus; signal transduction; Swine acute diarrhea syndrome; Swine acute diarrhea syndrome coronavirus,"Andrejeva, J., Childs, K.S., Young, D.F., Carlos, T.S., Stock, N., Goodbourn, S., Randall, R.E., The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter (2004) Proc. 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Immunol., 7, pp. 131-137; Koonpaew, S., Teeravechyan, S., Frantz, P.N., Chailangkarn, T., Jongkaewwattana, A., PEDV and PDCoV Pathogenesis: The Interplay Between Host Innate Immune Responses and Porcine Enteric Coronaviruses (2019) Front. Vet. Sci., 6, p. 34; Likai, J., Shasha, L., Wenxian, Z., Jingjiao, M., Jianhe, S., Hengan, W., Yaxian, Y., Porcine deltacoronavirus nucleocapsid protein suppressed IFN-beta production by interfering porcine RIG-I dsRNA-Binding and K63-Linked polyubiquitination (2019) Front. Immunol., 10, p. 1024; Li, J., Liu, Y., Zhang, X., Murine coronavirus induces type I interferon in oligodendrocytes through recognition by RIG-I and MDA5 (2010) J. Virol., 84, pp. 6472-6482; Lui, P.Y., Wong, L.Y., Fung, C.L., Siu, K.L., Yeung, M.L., Yuen, K.S., Chan, C.P., Jin, D.Y., Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through the inhibition of TBK1-dependent phosphorylation of IRF3 (2016) Emerg. Microbes Infect., 5, p. e39; Luo, J., Fang, L., Dong, N., Fang, P., Ding, Z., Wang, D., Chen, H., Xiao, S., Porcine deltacoronavirus (PDCoV) infection suppresses RIG-I-mediated interferon-beta production (2016) Virology, 495, pp. 10-17; Luo, R., Xiao, S., Jiang, Y., Jin, H., Wang, D., Liu, M., Chen, H., Fang, L., Porcine reproductive and respiratory syndrome virus (PRRSV) suppresses interferon-beta production by interfering with the RIG-I signaling pathway (2008) Mol. Immunol., 45, pp. 2839-2846; Pan, Y., Tian, X., Qin, P., Wang, B., Zhao, P., Yang, Y., Huang, Y., Discovery of a novel swine enteric alphacoronavirus (SeACoV) in southern China (2017) Vet. Microbiol., 211, pp. 15-21; Roth-Cross, J.K., Martinez-Sobrido, L., Scott, E.P., Garcia-Sastre, A., SR, W., Inhibition of the alpha/beta interferon response by mouse hepatitis virus at multiple levels (2007) J. 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Kimball Research Institute, New York Blood Center, New York, NY, United States; Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei Province, China","Wan, Y., Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN, United States; Shang, J., Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN, United States; Sun, S., Laboratory of Infection and Immunity, Beijing Institute of Microbiology and Epidemiology, Beijing, China; Tai, W., Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, United States; Chen, J., Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei Province, China; Geng, Q., Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN, United States; He, L., Laboratory of Infection and Immunity, Beijing Institute of Microbiology and Epidemiology, Beijing, China; Chen, Y., Laboratory of Infection and Immunity, Beijing Institute of Microbiology and Epidemiology, Beijing, China; Wu, J., Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN, United States; Shi, Z., Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei Province, China; Zhou, Y., Laboratory of Infection and Immunity, Beijing Institute of Microbiology and Epidemiology, Beijing, China; Du, L., Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, United States; Li, F., Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN, United States","Antibody-dependent enhancement (ADE) of viral entry has been a major concern for epidemiology, vaccine development, and antibody-based drug therapy. However, the molecular mechanism behind ADE is still elusive. Coronavirus spike protein mediates viral entry into cells by first binding to a receptor on the host cell surface and then fusing viral and host membranes. In this study, we investigated how a neutralizing monoclonal antibody (MAb), which targets the receptor-binding domain (RBD) of Middle East respiratory syndrome (MERS) coronavirus spike, mediates viral entry using pseudovirus entry and biochemical assays. Our results showed that MAb binds to the virus surface spike, allowing it to undergo conformational changes and become prone to proteolytic activation. Meanwhile, MAb binds to cell surface IgG Fc receptor, guiding viral entry through canonical viral-receptor-dependent pathways. Our data suggest that the antibody/Fc-receptor complex functionally mimics viral receptor in mediating viral entry. Moreover, we characterized MAb dosages in viral-receptor-dependent, Fc-receptor-dependent, and both-receptors-dependent viral entry pathways, delineating guidelines on MAb usages in treating viral infections. Our study reveals a novel molecular mechanism for antibody-enhanced viral entry and can guide future vaccination and antiviral strategies. IMPORTANCE Antibody-dependent enhancement (ADE) of viral entry has been observed for many viruses. It was shown that antibodies target one serotype of viruses but only subneutralize another, leading to ADE of the latter viruses. Here we identify a novel mechanism for ADE: a neutralizing antibody binds to the surface spike protein of coronaviruses like a viral receptor, triggers a conformational change of the spike, and mediates viral entry into IgG Fc receptor-expressing cells through canonical viral-receptor-dependent pathways. We further evaluated how antibody dosages impacted viral entry into cells expressing viral receptor, Fc receptor, or both receptors. This study reveals complex roles of antibodies in viral entry and can guide future vaccine design and antibody-based drug therapy. Copyright © 2020 American Society for Microbiology. All Rights Reserved.",Antibody-dependent enhancement of viral entry; Antibody-dependent enhancement of viral entry; IgG Fc receptor; MERS coronavirus; Neutralizing antibody; SARS coronavirus; Spike protein; Viral receptor,"Fc receptor; monoclonal antibody; virus receptor; coronavirus spike glycoprotein; dipeptidyl peptidase IV; DPP4 protein, human; Fc receptor; Fc receptor IIa; immunoglobulin F(ab) fragment; monoclonal antibody; neutralizing antibody; peptide hydrolase; serine proteinase; trypsin; virus antibody; virus receptor; animal tissue; antibody dependent enhancement; Article; biochemical analysis; cell surface; conformational transition; controlled study; Coronavirinae; drug design; human; human cell; Middle East respiratory syndrome coronavirus; mouse; nonhuman; practice guideline; priority journal; receptor binding; vaccination; virus entry; virus spike; cell line; chemistry; immunology; metabolism; pathogenicity; physiology; protein conformation; protein domain; protein multimerization; Antibodies, Monoclonal; Antibodies, Neutralizing; Antibodies, Viral; Antibody-Dependent Enhancement; Cell Line; Dipeptidyl Peptidase 4; Humans; Immunoglobulin Fab Fragments; Middle East Respiratory Syndrome Coronavirus; Peptide Hydrolases; Proprotein Convertases; Protein Conformation; Protein Domains; Protein Multimerization; Receptors, Fc; Receptors, IgG; Receptors, Virus; Spike Glycoprotein, Coronavirus; Trypsin; Virus Internalization","Tirado, S.M., Yoon, K.J., Antibody-dependent enhancement of virus infection and disease (2003) Viral Immunol, 16, pp. 69-86. , https://doi.org/10.1089/088282403763635465; Takada, A., Kawaoka, Y., Antibody-dependent enhancement of viral infection: Molecular mechanisms and in vivo implications (2003) Rev Med Virol, 13, pp. 387-398. , https://doi.org/10.1002/rmv.405; Guzman, M.G., Alvarez, M., Rodriguez-Roche, R., Bernardo, L., Montes, T., Vazquez, S., Morier, L., Halstead, S.B., Neutralizing antibodies after infection with dengue 1 virus (2007) Emerg Infect Dis, 13, pp. 282-286. , https://doi.org/10.3201/eid1302.060539; 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II. Differential binding of GATA4 and Yin-Yang1 transcription factors and correlated receptor expression and function (2004) J Immunol, 172, pp. 7192-7199. , https://doi.org/10.4049/jimmunol.172.11.7192; Du, L., Tai, W., Yang, Y., Zhao, G., Zhu, Q., Sun, S., Liu, C., Li, F., Introduction of neutralizing immunogenicity index to the rational design of MERS coronavirus subunit vaccines (2016) Nat Commun, 7, p. 13473. , https://doi.org/10.1038/ncomms13473; Liu, C., Tang, J., Ma, Y., Liang, X., Yang, Y., Peng, G., Qi, Q., Li, F., Receptor usage and cell entry of porcine epidemic diarrhea coronavirus (2015) J Virol, 89, pp. 6121-6125. , https://doi.org/10.1128/JVI.00430-15; Yang, Y., Du, L., Liu, C., Wang, L., Ma, C., Tang, J., Baric, R.S., Li, F., Receptor usage and cell entry of bat coronavirus HKU4 provide insight into bat-to-human transmission of MERS coronavirus (2014) Proc Natl Acad Sci U S A, 111, pp. 12516-12521. , https://doi.org/10.1073/pnas.1405889111; Liu, C., Ma, Y., Yang, Y., Zheng, Y., Shang, J., Zhou, Y., Jiang, S., Li, F., Cell entry of porcine epidemic diarrhea coronavirus is activated by lysosomal proteases (2016) J Biol Chem, 291, pp. 24779-24786. , https://doi.org/10.1074/jbc.M116.740746; Chen, Y., Rajashankar, K.R., Yang, Y., Agnihothram, S.S., Liu, C., Lin, Y.L., Baric, R.S., Li, F., Crystal structure of the receptor-binding domain from newly emerged Middle East respiratory syndrome coronavirus (2013) J Virol, 87, pp. 10777-10783. , https://doi.org/10.1128/JVI.01756-13","Du, L.; Lindsley F. Kimball Research Institute, New York Blood CenterUnited States; email: LDu@nybc.org",,American Society for Microbiology,0022538X,,JOVIA,31826992,English,J. Virol.,Article,Final,Open Access,Scopus,2-s2.0-85079473033,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhao S., Lin Q., Ran J., Musa S.S., Yang G., Wang W., Lou Y., Gao D., Yang L., He D., Wang M.H.",57194229769;57214794747;57201898116;57207792527;57214807238;57204925889;16417276600;38861547100;57105980700;7403045834;55596673500;,"Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: A data-driven analysis in the early phase of the outbreak",2020,International Journal of Infectious Diseases,92,,,214,217,,24,10.1016/j.ijid.2020.01.050,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079180879&doi=10.1016%2fj.ijid.2020.01.050&partnerID=40&md5=26a5a286c06b1de73fb6b98b653d88ac,"JC School of Public Health and Primary Care, Chinese University of Hong Kong, Hong Kong, Hong Kong; Shenzhen Research Institute of Chinese University of Hong Kong, Shenzhen, China; Michigan Institute for Data Science, University of Michigan, Ann Arbor, MI, United States; School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, Hong Kong; Department of Applied Mathematics, Hong Kong Polytechnic University, Hong Kong, Hong Kong; Department of Orthopaedics and Traumatology, Chinese University of Hong Kong, Hong Kong, Hong Kong; SH Ho Scoliosis Research Lab, Joint Scoliosis Research Center of Chinese University of Hong Kong and Nanjing University, Hong Kong, Hong Kong; School of Mathematics and Statistics, Huaiyin Normal University, Huaian, China; Department of Mathematics, Shanghai Normal University, Shanghai, China; School of Nursing, Hong Kong Polytechnic University, Hong Kong, Hong Kong","Zhao, S., JC School of Public Health and Primary Care, Chinese University of Hong Kong, Hong Kong, Hong Kong, Shenzhen Research Institute of Chinese University of Hong Kong, Shenzhen, China; Lin, Q., Michigan Institute for Data Science, University of Michigan, Ann Arbor, MI, United States; Ran, J., School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, Hong Kong; Musa, S.S., Department of Applied Mathematics, Hong Kong Polytechnic University, Hong Kong, Hong Kong; Yang, G., Department of Orthopaedics and Traumatology, Chinese University of Hong Kong, Hong Kong, Hong Kong, SH Ho Scoliosis Research Lab, Joint Scoliosis Research Center of Chinese University of Hong Kong and Nanjing University, Hong Kong, Hong Kong; Wang, W., School of Mathematics and Statistics, Huaiyin Normal University, Huaian, China; Lou, Y., Department of Applied Mathematics, Hong Kong Polytechnic University, Hong Kong, Hong Kong; Gao, D., Department of Mathematics, Shanghai Normal University, Shanghai, China; Yang, L., School of Nursing, Hong Kong Polytechnic University, Hong Kong, Hong Kong; He, D., Department of Applied Mathematics, Hong Kong Polytechnic University, Hong Kong, Hong Kong; Wang, M.H., JC School of Public Health and Primary Care, Chinese University of Hong Kong, Hong Kong, Hong Kong, Shenzhen Research Institute of Chinese University of Hong Kong, Shenzhen, China","Backgrounds: An ongoing outbreak of a novel coronavirus (2019-nCoV) pneumonia hit a major city in China, Wuhan, December 2019 and subsequently reached other provinces/regions of China and other countries. We present estimates of the basic reproduction number, R0, of 2019-nCoV in the early phase of the outbreak. Methods: Accounting for the impact of the variations in disease reporting rate, we modelled the epidemic curve of 2019-nCoV cases time series, in mainland China from January 10 to January 24, 2020, through the exponential growth. With the estimated intrinsic growth rate (γ), we estimated R0 by using the serial intervals (SI) of two other well-known coronavirus diseases, MERS and SARS, as approximations for the true unknown SI. Findings: The early outbreak data largely follows the exponential growth. We estimated that the mean R0 ranges from 2.24 (95%CI: 1.96–2.55) to 3.58 (95%CI: 2.89–4.39) associated with 8-fold to 2-fold increase in the reporting rate. We demonstrated that changes in reporting rate substantially affect estimates of R0. Conclusion: The mean estimate of R0 for the 2019-nCoV ranges from 2.24 to 3.58, and is significantly larger than 1. Our findings indicate the potential of 2019-nCoV to cause outbreaks. © 2020 The Author(s)",Basic reproduction number; Novel coronavirus (2019-nCoV),2019 novel coronavirus; Article; basic reproduction number; China; clinical assessment; clinical evaluation; Coronavirinae; Coronavirus infection; epidemic; growth rate; human; Middle East respiratory syndrome; outcome assessment; severe acute respiratory syndrome; time series analysis; virus transmission; Betacoronavirus; Coronavirus infection; epidemic; Middle East respiratory syndrome coronavirus; physiology; SARS coronavirus; World Health Organization; severe acute respiratory syndrome coronavirus 2; Basic Reproduction Number; Betacoronavirus; China; Coronavirus Infections; Epidemics; Humans; Middle East Respiratory Syndrome Coronavirus; SARS Virus; World Health Organization,"Assiri, A., McGeer, A., Perl, T.M., Price, C.S., Al Rabeeah, A.A., Cummings, D.A., Alabdullatif, Z.N., Makhdoom, H., Hospital outbreak of Middle East respiratory syndrome coronavirus (2013) New Engl J Med, 369 (5), pp. 407-416; Bauch, C.T., Lloyd-Smith, J.O., Coffee, M.P., Galvani, A.P., Dynamically modeling SARS and other newly emerging respiratory illnesses: past, present, and future (2005) Epidemiol (Cambridge, Mass), 16 (6), pp. 791-801; Bogoch, I.I., Watts, A., Thomas-Bachli, A., Huber, C., Kraemer, M.U., Khan, K., Pneumonia of unknown etiology in Wuhan, China: potential for international spread via commercial air travel (2020) J Travel Med; Cowling, B.J., Fang, V.J., Riley, S., Peiris, J.M., Leung, G.M., Estimation of the serial interval of influenza (2009) Epidemiology (Cambridge, Mass), 20 (3), p. 344; de Silva, U., Warachit, J., Waicharoen, S., Chittaganpitch, M., A preliminary analysis of the epidemiology of influenza A (H1N1) v virus infection in Thailand from early outbreak data, June-July 2009 (2009) Eurosurveillance, 14 (31), p. 19292; Donnelly, C.A., Ghani, A.C., Leung, G.M., Hedley, A.J., Fraser, C., Riley, S., Epidemiological determinants of spread of causal agent of severe acute respiratory syndrome in Hong Kong (2003) Lancet (London, England), 361 (9371), pp. 1761-1766; Hubei provincial government, Strengthening the new coronavirus infection of pneumonia prevention and control (2020), http://www.hubei.gov.cn/xxgk/gsgg/202001/t20200122_2013895.shtml, Hubei provincial government; Imai, N., Dorigatti, I., Cori, A., Riley, S., Ferguson, N.M., Estimating the potential total number of novel Coronavirus (2019-nCoV) cases in Wuhan City (2020), https://www.imperial.ac.uk/mrc-global-infectious-disease-analysis/news--wuhan-coronavirus/, Preprint published by the Imperial College London China; Leung, K., Wu, J.T., Leung, G.M., Nowcasting and forecasting the Wuhan 2019-nCoV outbreak (2020), https://files.sph.hku.hk/download/wuhan_exportation_preprint.pdf, Preprint published by the School of Public Health of the University of Hong Kong; Lin, Q., Chiu, A.P., Zhao, S., He, D., Modeling the spread of Middle East respiratory syndrome coronavirus in Saudi Arabia (2018) Stat Methods Med Res, 27 (7), pp. 1968-1978; Lipsitch, M., Cohen, T., Cooper, B., Robins, J.M., Ma, S., James, L., Transmission dynamics and control of severe acute respiratory syndrome (2003) Science, 300 (5627), pp. 1966-1970; National Health Commission of the People's Republic of China, ‘Definition of suspected cases of unexplained pneumonia’, the National Health Commission of the People's Republic of China (in Chinese) (2020), http://www.nhc.gov.cn/; Read, J.M., Bridgen, J.R., Cummings, D.A., Ho, A., Jewell, C.P., Novel coronavirus 2019-nCoV: early estimation of epidemiological parameters and epidemic predictions (2020) medRxiv, , 2020.2001.2023.20018549; Riou, J., Althaus, C.L., Pattern of early human-to-human transmission of Wuhan 2019-nCoV (2020) bioRxiv, , 2020.2001.2023.917351; Shen, M., Peng, Z., Xiao, Y., Zhang, L., Modelling the epidemic trend of the 2019 novel coronavirus outbreak in China (2020) bioRxiv, 2020. , 2001.2023.916726; Wallinga, J., Lipsitch, M., How generation intervals shape the relationship between growth rates and reproductive numbers (2007) Proc R Soc B: Biolo Sci, 274 (1609), pp. 599-604; Wallinga, J., Teunis, P., Different epidemic curves for severe acute respiratory syndrome reveal similar impacts of control measures (2004) Am J Epidemiol, 160 (6), pp. 509-516; World Health Organization, ‘Pneumonia of unknown cause – China’, Emergencies preparedness, response, Disease outbreak news, World Health Organization (WHO) (2020), https://www.who.int/csr/don/05-january-2020-pneumonia-of-unkown-cause-china/en/; World Health Organization, Laboratory testing for 2019 novel coronavirus (2019-nCoV) in suspected human cases, World Health Organization (WHO) (2020), https://www.who.int/health-topics/coronavirus/laboratory-diagnostics-for-novel-coronavirus; Wu, J.T., Cowling, B.J., Lau, E.H., Ip, D.K., Ho, L.-M., Tsang, T., School closure and mitigation of pandemic (H1N1) 2009, Hong Kong (2010) Emerg Infect Dis, 16 (3), p. 538; Wuhan Municipal Health Commission, China, ‘News press and situation reports of the pneumonia caused by novel coronavirus’, from December 31, 2019 to January 21, 2020 released by the Wuhan municipal health commission, China (2020), http://wjw.wuhan.gov.cn/front/web/list2nd/no/710; Zhao, S., Musa, S.S., Fu, H., He, D., Qin, J., Simple framework for real-time forecast in a data-limited situation: the Zika virus (ZIKV) outbreaks in Brazil from 2015 to 2016 as an example (2019) Parasites Vectors, 12 (1), p. 344","Zhao, S.; JC School of Public Health and Primary Care, Chinese University of Hong KongHong Kong; email: shi.zhao@link.cuhk.edu.hk",,Elsevier B.V.,12019712,,IJIDF,32007643,English,Int. J. Infect. Dis.,Article,Final,Open Access,Scopus,2-s2.0-85079180879,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Yuan Y., Qi J., Peng R., Li C., Lu G., Yan J., Wang Q., Gao G.F.",56377018000;23089172800;57191273580;57208707633;35111348400;7403729391;55780637000;7403171212;,Molecular basis of binding between Middle East respiratory syndrome coronavirus and CD26 from seven bat species,2020,Journal of Virology,94,5, e01387-19,,,,,10.1128/JVI.01387-19,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079471809&doi=10.1128%2fJVI.01387-19&partnerID=40&md5=da650bc9c94d365cb225da13f2527d92,"CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China; West China Hospital Emergency Department, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan, China; CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China; Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People’s Hospital, Shenzhen, China; Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China","Yuan, Y., CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China; Qi, J., CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China; Peng, R., CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China; Li, C., CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China; Lu, G., West China Hospital Emergency Department, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan, China; Yan, J., CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China, CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China, Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People’s Hospital, Shenzhen, China; Wang, Q., CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China, Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People’s Hospital, Shenzhen, China; Gao, G.F., CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China, Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People’s Hospital, Shenzhen, China, Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China","Continued reports of Middle East respiratory syndrome coronavirus (MERS-CoV) infecting humans have occurred since the identification of this virus in 2012. MERS-CoV is prone to cause endemic disease in the Middle East, with several dozen spillover infections to other continents. It is hypothesized that MERS-CoV originated from bat coronaviruses and that dromedary camels are its natural reservoir. Although gene segments identical to MERS-CoV were sequenced from certain species of bats and one species experimentally shed the virus, it is still unknown whether other bats can transmit the virus. Here, at the molecular level, we found that all purified bat CD26s (bCD26s) from a diverse range of species interact with the receptor binding domain (RBD) of MERS-CoV, with equilibrium dissociation constant values ranging from several to hundreds at the micromolar level. Moreover, all bCD26s expressed in this study mediated the entry of pseudotyped MERS-CoV to receptor-expressing cells, indicating the broad potential engagement of bCD26s as MERS-CoV receptors. Further structural analysis indicated that in the bat receptor, compared to the human receptor, substitutions of key residues and their adjacent amino acids leads to decreased binding affinity to the MERS-RBD. These results add more evidence to the existing belief that bats are the original source of MERS-CoV and suggest that bCD26s in many species can mediate the entry of the virus, which has significant implications for the surveillance and control of MERS-CoV infection. IMPORTANCE In this study, we found that bat CD26s (bCD26s) from different species exhibit large diversities, especially in the region responsible for binding to the receptor binding domain (RBD) of Middle East respiratory syndrome coronavirus (MERS-CoV). However, they maintain the interaction with MERS-RBD at varied affinities and support the entry of pseudotyped MERS-CoV. These bat receptors polymorphisms seem to confer evolutionary pressure for the adaptation of CD26-binding virus, such as the ancestor of MERS-CoV, and led to the generation of diversified CD26-engaging CoV strains. Thus, our data add more evidence to support that bats are the reservoir of MERS-CoV and similar viruses, as well as further emphasize the necessity to survey MERS-CoV and other CoVs among bats. Copyright © 2020 American Society for Microbiology. All Rights Reserved.",Bat CD26; Evolution; Interspecies transmission; MERS-CoV; MERS-RBD; Receptor,dipeptidyl peptidase IV; Article; bat; binding affinity; controlled study; disease surveillance; human; infection control; Middle East respiratory syndrome; Middle East respiratory syndrome coronavirus; nonhuman; priority journal; protein binding; protein expression; protein purification; receptor binding,"Zaki, A.M., van Boheemen, S., Bestebroer, T.M., Osterhaus, A.D., Fouchier, R.A., Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia (2012) N Engl J Med, 367, pp. 1814-1820. , https://doi.org/10.1056/NEJMoa1211721; Chan, J.F.W., Lau, S.K.P., To, K.K.W., Cheng, V.C.C., Woo, P.C.Y., Yuen, K.Y., Middle East respiratory syndrome coronavirus: Another zoonotic betacoronavirus causing SARS-like disease (2015) Clin Microbiol Rev, 28, pp. 465-522. , https://doi.org/10.1128/CMR.00102-14; Ma, Y., Feng, Y., Liu, D., Gao, G.F., Avian influenza virus, Streptococcus suis serotype 2, severe acute respiratory syndrome-coronavirus and beyond: Molecular epidemiology, ecology, and the situation in China (2009) Philos Trans R Soc Lond B Biol Sci, 364, pp. 2725-2737. , https://doi.org/10.1098/rstb.2009.0093; Zhu, J., Xiao, G., Xu, Y., Yuan, F., Zheng, C., Liu, Y., Yan, H., Gao, G.F., Following the rule: Formation of the 6-helix bundle of the fusion core from severe acute respiratory syndrome coronavirus spike protein and identification of potent peptide inhibitors (2004) Biochem Biophys Res Commun, 319, pp. 283-288. , https://doi.org/10.1016/j.bbrc.2004.04.141; (2019) Middle East Respiratory Syndrome Coronavirus (MERS-CoV), , https://www.who.int/csr/don/26-february-2019-mers-saudi-arabia/en/, World Health Organization, Geneva, Switzerland; Knipe, D.M., Howley, P.M., (2013) Fields Virology, , 6th ed. Wolters Kluwer/ Lippincott/Williams & Wilkins Health, Philadelphia, PA; Woo, P.C., Lau, S.K., Lam, C.S., Lau, C.C., Tsang, A.K., Lau, J.H., Bai, R., Yuen, K.Y., Discovery of seven novel mammalian and avian coronaviruses in the genus deltacoronavirus supports bat coronaviruses as the gene source of alphacoronavirus and betacoronavirus and avian coronaviruses as the gene source of gammacoronavirus and deltacoronavirus (2012) J Virol, 86, pp. 3995-4008. , https://doi.org/10.1128/JVI.06540-11; Lu, G., Wang, Q., Gao, G.F., Bat-to-human: Spike features determining ‘host jump’ of coronaviruses SARS-CoV, MERS-CoV, and beyond (2015) Trends Microbiol, 23, pp. 468-478. , https://doi.org/10.1016/j.tim.2015.06.003; Guan, Y., Zheng, B.J., He, Y.Q., Liu, X.L., Zhuang, Z.X., Cheung, C.L., Luo, S.W., Poon, L.L., Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China (2003) Science, 302, pp. 276-278. , https://doi.org/10.1126/science.1087139; Ge, X.-Y., Li, J.-L., Yang, X.-L., Chmura, A.A., Zhu, G., Epstein, J.H., Mazet, J.K., Shi, Z.-L., Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor (2013) Nature, 503, pp. 535-538. , https://doi.org/10.1038/nature12711; Cotten, M., Watson, S.J., Kellam, P., Al-Rabeeah, A.A., Makhdoom, H.Q., Assiri, A., Al-Tawfiq, J.A., Memish, Z.A., Transmission and evolution of the Middle East respiratory syndrome coronavirus in Saudi Arabia: A descriptive genomic study (2013) Lancet, 382, pp. 1993-2002. , https://doi.org/10.1016/S0140-6736(13)61887-5; Cotten, M., Watson, S.J., Zumla, A.I., Makhdoom, H.Q., Palser, A.L., Ong, S.H., Al Rabeeah, A.A., Memish, Z.A., Spread, circulation, and evolution of the Middle East respiratory syndrome coronavirus (2014) mBio, 5, pp. e01062-e01113; Reusken, C.B., Schilp, C., Raj, V.S., de Bruin, E., Kohl, R.H., Farag, E.A., Haagmans, B.L., Koopmans, M.P., MERS-CoV infection of alpaca in a region where MERS-CoV is endemic (2016) Emerg Infect Dis, 22, pp. 1129-1131. , https://doi.org/10.3201/eid2206.152113; Adney, D.R., Bielefeldt-Ohmann, H., Hartwig, A.E., Bowen, R.A., Infection, replication, and transmission of Middle East respiratory syndrome coronavirus in alpacas (2016) Emerg Infect Dis, 22, pp. 1031-1037. , https://doi.org/10.3201/2206.160192; Memish, Z.A., Mishra, N., Olival, K.J., Fagbo, S.F., Kapoor, V., Epstein, J.H., Alhakeem, R., Lipkin, W.I., Middle East respiratory syndrome coronavirus in bats, Saudi Arabia (2013) Emerg Infect Dis, 19, pp. 1819-1823. , https://doi.org/10.3201/eid1911.131172; Ithete, N.L., Stoffberg, S., Corman, V.M., Cottontail, V.M., Richards, L.R., Schoeman, M.C., Drosten, C., Preiser, W., Close relative of human Middle East respiratory syndrome coronavirus in bat, South Africa (2013) Emerg Infect Dis, 19, pp. 1697-1699. , https://doi.org/10.3201/eid1910.130946; Letko, M., Miazgowicz, K., McMinn, R., Seifert, S.N., Sola, I., Enjuanes, L., Carmody, A., Munster, V., Adaptive evolution of MERS-CoV to species variation in DPP4 (2018) Cell Rep, 24, pp. 1730-1737. , https://doi.org/10.1016/j.celrep.2018.07.045; Caì, Y., Yú, S.Q., Postnikova, E.N., Mazur, S., Bernbaum, J.G., Burk, R., Zhang, T., Kuhn, J.H., CD26/DPP4 cell-surface expression in bat cells correlates with bat cell susceptibility to Middle East respiratory syndrome coronavirus (MERS-CoV) infection and evolution of persistent infection (2014) PLoS One, 9. , https://doi.org/10.1371/journal.pone.0112060; Munster, V.J., Adney, D.R., van Doremalen, N., Brown, V.R., Miazgowicz, K.L., Milne-Price, S., Bushmaker, T., Bowen, R.A., Replication and shedding of MERS-CoV in Jamaican fruit bats (Artibeus jamaicensis) (2016) Sci Rep, 6, p. 21878. , https://doi.org/10.1038/srep21878; Dingle, H., (1996) Migration: The Biology of Life on the Move, , Oxford University Press, New York, NY; Wang, Q., Wong, G., Lu, G., Yan, J., Gao, G.F., MERS-CoV spike protein: Targets for vaccines and therapeutics (2016) Antiviral Res, 133, pp. 165-177. , https://doi.org/10.1016/j.antiviral.2016.07.015; Xu, Y., Lou, Z., Liu, Y., Pang, H., Tien, P., Gao, G.F., Rao, Z., Crystal structure of severe acute respiratory syndrome coronavirus spike protein fusion core (2004) J Biol Chem, 279, pp. 49414-49419. , https://doi.org/10.1074/jbc.M408782200; Yuan, Y., Cao, D., Zhang, Y., Ma, J., Qi, J., Wang, Q., Lu, G., Gao, G.F., Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains (2017) Nat Commun, 8, p. 15092. , https://doi.org/10.1038/ncomms15092; 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Peck, K.M., Cockrell, A.S., Yount, B.L., Scobey, T., Baric, R.S., Heise, M.T., Glycosylation of mouse DPP4 plays a role in inhibiting Middle East respiratory syndrome coronavirus infection (2015) J Virol, 89, pp. 4696-4699. , https://doi.org/10.1128/JVI.03445-14; Read, R.J., Pushing the boundaries of molecular replacement with maximum likelihood (2001) Acta Crystallogr D Biol Crystallogr, 57, pp. 1373-1382. , https://doi.org/10.1107/s0907444901012471; The CCP4 suite: Programs for protein crystallography (1994) Acta Crystallogr D, 50, pp. 760-763. , https://doi.org/10.1107/S0907444994003112; Emsley, P., Cowtan, K., Coot: Model-building tools for molecular graphics (2004) Acta Crystallogr D Biol Crystallogr, 60, pp. 2126-2132. , https://doi.org/10.1107/S0907444904019158; Adams, P.D., Afonine, P.V., Bunkoczi, G., Chen, V.B., Davis, I.W., Echols, N., Headd, J.J., Zwart, P.H., Phenix: A comprehensive Python-based system for macromolecular structure solution (2010) Acta Crystallogr D Biol Crystallogr, 66, pp. 213-221. , https://doi.org/10.1107/S0907444909052925","Wang, Q.; CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of SciencesChina; email: wangqihui@im.ac.cn",,American Society for Microbiology,0022538X,,JOVIA,31776269,English,J. Virol.,Article,Final,Open Access,Scopus,2-s2.0-85079471809,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Tolksdorf K., Buda S., Schuler E., Wieler L.H., Haas W.",56199208300;7004153382;56829119600;57216109165;7102876924;,Influenza-associated pneumonia as reference to assess seriousness of coronavirus disease (COVID-19),2020,Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin,25,11,,,,,,10.2807/1560-7917.ES.2020.25.11.2000258,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082392110&doi=10.2807%2f1560-7917.ES.2020.25.11.2000258&partnerID=40&md5=5d7d7036a4a642f93a197ad9ed3c53d2,"Robert Koch InstituteBerlin, Germany; Helios Kliniken GmbHBerlin, Germany","Tolksdorf, K., Robert Koch InstituteBerlin, Germany; Buda, S., Robert Koch InstituteBerlin, Germany; Schuler, E., Helios Kliniken GmbHBerlin, Germany; Wieler, L.H., Robert Koch InstituteBerlin, Germany; Haas, W., Robert Koch InstituteBerlin, Germany","Information on severity of coronavirus disease (COVID-19) (transmissibility, disease seriousness, impact) is crucial for preparation of healthcare sectors. We present a simple approach to assess disease seriousness, creating a reference cohort of pneumonia patients from sentinel hospitals. First comparisons exposed a higher rate of COVID-19 patients requiring ventilation. There were more case fatalities among COVID-19 patients without comorbidities than in the reference cohort. Hospitals should prepare for high utilisation of ventilation and intensive care resources.",COVID-19; hospital; pneumonia; SARS-CoV-2; seriousness of disease,,,,,NLM (Medline),15607917,,,32186278,English,Euro Surveill.,Article,Final,Open Access,Scopus,2-s2.0-85082392110,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Kinross P., Suetens C., Gomes Dias J., Alexakis L., Wijermans A., Colzani E., Monnet D.L., European Centre For Disease Prevention And Control Ecdc Public Health Emergency Team",56120834500;6602569465;57195932749;57215688260;57215929493;23476360100;16740779400;57215929378;,"Rapidly increasing cumulative incidence of coronavirus disease (COVID-19) in the European Union/European Economic Area and the United Kingdom, 1 January to 15 March 2020",2020,Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin,25,11,,,,,,10.2807/1560-7917.ES.2020.25.11.2000285,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082384658&doi=10.2807%2f1560-7917.ES.2020.25.11.2000285&partnerID=40&md5=f7ae3391db83717e8b6c1cf49e6bc6c6,"European Centre for Disease Prevention and Control, Solna, Sweden; members of the ECDC Public Health Emergency Team are listed at the end of this article","Kinross, P., European Centre for Disease Prevention and Control, Solna, Sweden; Suetens, C., European Centre for Disease Prevention and Control, Solna, Sweden; Gomes Dias, J., European Centre for Disease Prevention and Control, Solna, Sweden; Alexakis, L., European Centre for Disease Prevention and Control, Solna, Sweden; Wijermans, A., European Centre for Disease Prevention and Control, Solna, Sweden; Colzani, E., European Centre for Disease Prevention and Control, Solna, Sweden; Monnet, D.L., European Centre for Disease Prevention and Control, Solna, Sweden; European Centre For Disease Prevention And Control Ecdc Public Health Emergency Team, members of the ECDC Public Health Emergency Team are listed at the end of this article","The cumulative incidence of coronavirus disease (COVID-19) cases is showing similar trends in European Union/European Economic Area countries and the United Kingdom confirming that, while at a different stage depending on the country, the COVID-19 pandemic is progressing rapidly in all countries. Based on the experience from Italy, countries, hospitals and intensive care units should increase their preparedness for a surge of patients with COVID-19 who will require healthcare, and in particular intensive care.","coronavirus, EU/EEA, United Kingdom, Europe; SARS-CoV-2, COVID-19, coronavirus disease",,,,,NLM (Medline),15607917,,,32186277,English,Euro Surveill.,Article,Final,Open Access,Scopus,2-s2.0-85082384658,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Xing Y., Mo P., Xiao Y., Zhao O., Zhang Y., Wang F.",57215693478;53264428100;57215839576;57215839736;57215848084;56661453600;,"Post-discharge surveillance and positive virus detection in two medical staff recovered from coronavirus disease 2019 (COVID-19), China, January to February 2020",2020,Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin,25,10,,,,,,10.2807/1560-7917.ES.2020.25.10.2000191,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082088826&doi=10.2807%2f1560-7917.ES.2020.25.10.2000191&partnerID=40&md5=dff66f784505665ef20508a17ef35184,"These authors contributed equally to this study; Department of Biological Repositories, Zhongnan Hospital of Wuhan University, Wuhan, China; Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China; Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China","Xing, Y., These authors contributed equally to this study, Department of Biological Repositories, Zhongnan Hospital of Wuhan University, Wuhan, China; Mo, P., These authors contributed equally to this study, Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China; Xiao, Y., These authors contributed equally to this study, Department of Biological Repositories, Zhongnan Hospital of Wuhan University, Wuhan, China; Zhao, O., Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China; Zhang, Y., Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China; Wang, F., Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, China","Since December 2019, 62 medical staff of Zhongnan Hospital in Wuhan, China have been hospitalised with coronavirus disease 2019. During the post-discharge surveillance after clinical recovery, swabs were positive in two asymptomatic cases (3.23%). Case 1 had presented typical clinical and radiological manifestations on admission, while manifestation in Case 2 was very mild. In conclusion, a small proportion of recovered patients may test positive after discharge, and post-discharge surveillance and isolation need to be strengthened.",COVID-19; medical staff; positive detection; post-discharge surveillance,"COVID-19; severe acute respiratory syndrome coronavirus 2; adult; asymptomatic infection; Betacoronavirus; Coronavirus infection; disease transmission; female; genetics; hospital discharge; hospitalization; human; isolation and purification; male; pharynx; predictive value; radiography; real time polymerase chain reaction; virology; virus pneumonia; x-ray computed tomography; Adult; Asymptomatic Infections; Betacoronavirus; Coronavirus Infections; Female; Hospitalization; Humans; Infectious Disease Transmission, Patient-to-Professional; Male; Patient Discharge; Pharynx; Pneumonia, Viral; Predictive Value of Tests; Radiography; Real-Time Polymerase Chain Reaction; Tomography, X-Ray Computed",,,,NLM (Medline),15607917,,,32183934,English,Euro Surveill.,Article,Final,Open Access,Scopus,2-s2.0-85082088826,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Ashour H.M., Elkhatib W.F., Rahman M.M., Elshabrawy H.A.",56260407900;56593725900;57212184272;55498299000;,Insights into the recent 2019 novel coronavirus (Sars-coV-2) in light of past human coronavirus outbreaks,2020,Pathogens,9,3,186,,,,,10.3390/pathogens9030186,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082124062&doi=10.3390%2fpathogens9030186&partnerID=40&md5=bc7506cd7b9bc51c4663deca34de34fb,"Department of Biological Sciences, College of Arts and Sciences, University of South Florida St. Petersburg, St. Petersburg, FL 33701, United States; Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt; Department of Microbiology and Immunology, School of Pharmacy & Pharmaceutical Industries, Badr University in Cairo (BUC), Entertainment Area, Badr City, Cairo 11829, Egypt; Microbiology and Immunology Department, Faculty of Pharmacy, Ain Shams University, African Union Organization St, Abbassia, Cairo 11566, Egypt; Department of Pathology, Faculty of Veterinary, Animal and Biomedical Sciences, Sylhet Agricultural University, Sylhet, 3100, Bangladesh; Department of Molecular and Cellular Biology, College of Osteopathic Medicine, Sam Houston State University, Conroe, TX 77304, United States","Ashour, H.M., Department of Biological Sciences, College of Arts and Sciences, University of South Florida St. Petersburg, St. Petersburg, FL 33701, United States, Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt; Elkhatib, W.F., Department of Microbiology and Immunology, School of Pharmacy & Pharmaceutical Industries, Badr University in Cairo (BUC), Entertainment Area, Badr City, Cairo 11829, Egypt, Microbiology and Immunology Department, Faculty of Pharmacy, Ain Shams University, African Union Organization St, Abbassia, Cairo 11566, Egypt; Rahman, M.M., Department of Pathology, Faculty of Veterinary, Animal and Biomedical Sciences, Sylhet Agricultural University, Sylhet, 3100, Bangladesh; Elshabrawy, H.A., Department of Molecular and Cellular Biology, College of Osteopathic Medicine, Sam Houston State University, Conroe, TX 77304, United States","Coronaviruses (CoVs) are RNA viruses that have become a major public health concern since the Severe Acute Respiratory Syndrome-CoV (SARS-CoV) outbreak in 2002. The continuous evolution of coronaviruses was further highlighted with the emergence of the Middle East Respiratory Syndrome-CoV (MERS-CoV) outbreak in 2012. Currently, the world is concerned about the 2019 novel CoV (SARS-CoV-2) that was initially identified in the city of Wuhan, China in December 2019. Patients presented with severe viral pneumonia and respiratory illness. The number of cases has been mounting since then. As of late February 2020, tens of thousands of cases and several thousand deaths have been reported in China alone, in addition to thousands of cases in other countries. Although the fatality rate of SARS-CoV-2 is currently lower than SARS-CoV, the virus seems to be highly contagious based on the number of infected cases to date. In this review, we discuss structure, genome organization, entry of CoVs into target cells, and provide insights into past and present outbreaks. The future of human CoV outbreaks will not only depend on how the viruses will evolve, but will also depend on how we develop efficient prevention and treatment strategies to deal with this continuous threat. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.",2019-nCoV; COVID-19; MERS; SARS; SARS-CoV-2,adult; China; genome analysis; human; mortality rate; nonhuman; review; SARS coronavirus; target cell,"Woo, P.C., Huang, Y., Lau, S.K., Yuen, K.Y., Coronavirus genomics and bioinformatics analysis (2010) Viruses, 2, pp. 1804-1820; Woo, P.C., Lau, S.K., Lam, C.S., Lau, C.C., Tsang, A.K., Lau, J.H., Bai, R., Wang, M., Discovery of seven novel Mammalian and avian coronaviruses in the genus deltacoronavirus supports bat coronaviruses as the gene source of alphacoronavirus and betacoronavirus and avian coronaviruses as the gene source of gammacoronavirus and deltacoronavirus (2012) J. 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Rep., 8; Coughlin, M., Lou, G., Martinez, O., Masterman, S.K., Olsen, O.A., Moksa, A.A., Farzan, M., Prabhakar, B.S., Generation and characterization of human monoclonal neutralizing antibodies with distinct binding and sequence features against SARS coronavirus using XenoMouse (2007) Virology, 361, pp. 93-102. , In English; Tang, X.C., Agnihothram, S.S., Jiao, Y., Stanhope, J., Graham, R.L., Peterson, E.C., Avnir, Y., Zhu, Q., Identification of human neutralizing antibodies against MERS-CoV and their role in virus adaptive evolution (2014) Proc. Natl. Acad. Sci, 111; Zhang, H., Wang, G., Li, J., Nie, Y., Shi, X., Lian, G., Wang, W., Qu, X., Identification of an antigenic determinant on the S2 domain of the severe acute respiratory syndrome coronavirus spike glycoprotein capable of inducing neutralizing antibodies (2004) J. 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Dis, 20, pp. 2093-2095; Lau, S.K.P., Zhang, L., Luk, H.K.H., Xiong, L., Peng, X., Li, K.S.M., He, X., Wong, A.C.P., Receptor Usage of a Novel Bat Lineage C Betacoronavirus Reveals Evolution of Middle East Respiratory Syndrome-Related Coronavirus Spike Proteins for Human Dipeptidyl Peptidase 4 Binding (2018) J. Infect. Dis, 218, pp. 197-207. , In English; Zhang, Z., Shen, L., Gu, X., Evolutionary Dynamics of MERS-CoV: Potential Recombination (2016) Positive Selection and Transmission. Sci. Rep, 6, p. 25049; Rothe, C., Schunk, M., Sothmann, P., Bretzel, G., Froeschl, G., Wallrauch, C., Zimmer, T., Guggemos, W., Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany (2020) N. Engl. J. Med.; Benvenuto, D., Giovannetti, M., Ciccozzi, A., Spoto, S., Angeletti, S., Ciccozzi, M., The 2019-new coronavirus epidemic: Evidence for virus evolution (2020) J. Med. Virol; Gralinski, L.E., Menachery, V.D., (2020) Return of the Coronavirus: 2019-nCoV. Viruses, 12, p. 135. , In English; Dolan, P.T., Whitfield, Z.J., Andino, R., Mechanisms and Concepts in RNA Virus Population Dynamics and Evolution (2018) Annu. Rev. Virol., 5, pp. 69-92. , In English; Chan, J.F., Yuan, S., Kok, K.H., To, K.K., Chu, H., Yang, J., Xing, F., Poon, R.W., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: A study of a family cluster (2020) Lancet, 395, pp. 514-532; Ren, L.L., Wang, Y.M., Wu, Z.Q., Xiang, Z.C., Guo, L., Xu, T., Jiang, Y.Z., Li, H., Identification of a novel coronavirus causing severe pneumonia in human: A descriptive study (2020) Chin. Med J., , In English; Ng, P.C., Leung, C.W., Chiu, W.K., Wong, S.F., Hon, E.K., SARS in newborns and children (2004) Biol. Neonate, 85, pp. 293-298. , In English; Delamater, P.L., Street, E.J., Leslie, T.F., Yang, Y.T., Jacobsen, K.H., Complexity of the Basic Reproduction Number (R0) (2019) Emerg. Infect. 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Med.; Riou, J., Althaus, C.L., Pattern of early human-to-human transmission of Wuhan 2019 novel coronavirus (2019-nCoV), December 2019 to January 2020 (2020) Eurosurveillance, 25; Wu, J.T., Leung, K., Leung, G.M., Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: A modelling study (2020) Lancet; Liu, T., Hu, J., Kang, M., Lin, L., Zhong, H., Xiao, J., He, G., Rong, Z., Transmission dynamics of 2019 novel coronavirus (2019-nCoV (2020) Biorxiv; Lipsitch, M., Cohen, T., Cooper, B., Robins, J.M., Ma, S., James, L., Gopalakrishna, G., Samore, M.H., Transmission dynamics and control of severe acute respiratory syndrome (2003) Science, 300, pp. 1966-1970; Lin, Q., Chiu, A.P., Zhao, S., He, D., Modeling the spread of Middle East respiratory syndrome coronavirus in Saudi Arabia (2018) Stat Methods Med Res, 27, pp. 1968-1978; Chong, K.C., Zee, B.C.Y., Wang, M.H., Approximate Bayesian algorithm to estimate the basic reproduction number in an influenza pandemic using arrival times of imported cases (2018) Travel Med. Infect. Dis., 23, pp. 80-86. , In English; Backer, J.A., Klinkenberg, D., Wallinga, J., The incubation period of 2019-nCoV infections among travellers from Wuhan (2020) China. Medrxiv; C, Prevention. Smallpox--Stockholm, Sweden, 1963 (1996) MMWR Morb. Mortal. Wkly. Rep, 45, pp. 538-545; Suen, L.K.P., Guo, Y.P., Ho, S.S.K., Au-Yeung, C.H., Lam, S.C., Comparing mask fit and usability of traditional and nanofibre N95 filtering facepiece respirators before and after nursing procedures (2019) J. Hosp. Infect; Sandaradura, I., Goeman, E., Pontivivo, G., Fine, E., Gray, H., Kerr, S., Marriott, D., Andresen, D., A close shave? Performance of P2/N95 respirators in health care workers with facial hair: Results of the BEARDS (Adequate Respiratory DefenceS) study (2020) J. Hosp. Infect.; Conley, L., Tao, Y., Henry, A., Koepf, E., Cecchini, D., Pieracci, J., Ghose, S., Evaluation of eco-friendly zwitterionic detergents for enveloped virus inactivation (2017) Biotechnol. Bioeng, 114, pp. 813-820; Kampf, G., Efficacy of ethanol against viruses in hand disinfection (2018) J. Hosp. Infect., 98, pp. 331-338. , In English; Mahase, E., China coronavirus: WHO declares international emergency as death toll exceeds 200 (2020) BMJ, 368, pp. m408; Zarocostas, J., Ebola outbreak declared a PHEIC, world waits for next steps (2019) Lancet, 394, pp. 287-288; Luo, G.G., Gao, S.J., Global Health Concern Stirred by Emerging Viral Infections (2020) J. Med. Virol; Holshue, M.L., Debolt, C., Lindquist, S., Lofy, K.H., Wiesman, J., Bruce, H., Spitters, C., Tural, A., First Case of 2019 Novel Coronavirus in the United States (2020) N. Engl. J. Med., , In English; Yu, H., Cauchemez, S., Donnelly, C.A., Zhou, L., Feng, L., Xiang, N., Zheng, J., Liao, Q., Transmission dynamics, border entry screening, and school holidays during the 2009 influenza A (H1N1) pandemic, China (2012) Emerg. Infect. Dis., 18, pp. 758-766; Phelan, A.L., Katz, R., Gostin, L.O., The Novel Coronavirus Originating in Wuhan, China: Challenges for Global Health Governance (2020) JAMA, , In English; Virlogeux, V., Fang, V.J., Park, M., Wu, J.T., Cowling, B.J., Comparison of incubation period distribution of human infections with MERS-CoV in South Korea and Saudi Arabia (2016) Sci. Rep, 6; Chughtai, A.A., Barnes, M., Macintyre, C.R., Persistence of Ebola virus in various body fluids during convalescence: Evidence and implications for disease transmission and control (2016) Epidemiol. Infect., 144, pp. 1652-1660; Smith, J.R., Todd, S., Ashander, L.M., Charitou, T., Ma, Y., Yeh, S., Crozier, I., Williams, K.A., Retinal Pigment Epithelial Cells are a Potential Reservoir for Ebola Virus in the Human Eye (2017) Transl. Vis. Sci. Technol., 6, p. 12; Ashour, H.M., Immune tolerance elicited via unique ocular and oral routes (2015) Curr. Mol. Med., 15, pp. 78-81","Ashour, H.M.; Department of Biological Sciences, College of Arts and Sciences, University of South Florida St. PetersburgUnited States; email: hossamking@mailcity.com",,MDPI AG,20760817,,,,English,Pathogens,Review,Final,Open Access,Scopus,2-s2.0-85082124062,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Konrad R., Eberle U., Dangel A., Treis B., Berger A., Bengs K., Fingerle V., Liebl B., Ackermann N., Sing A.",36157162900;57203151960;55953904900;57195563290;34976248500;57195569992;56243292900;7003320596;57132559700;55916488300;,"Rapid establishment of laboratory diagnostics for the novel coronavirus SARS-CoV-2 in Bavaria, Germany, February 2020",2020,Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin,25,9,,,,,,10.2807/1560-7917.ES.2020.25.9.2000173,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081655719&doi=10.2807%2f1560-7917.ES.2020.25.9.2000173&partnerID=40&md5=aac2e284f51a0c10ff1e2459163d2e87,"These authors contributed equally to this work; Public Health Microbiology Unit, Bavarian Health and Food Safety Authority, Oberschleißheim, Germany; Unit of Virology, Bavarian Health and Food Safety Authority, Oberschleißheim, Germany; Ludwig Maximilians-Universität, Munich, Germany; State Institute of Health, Bavarian Health and Food Safety Authority, Oberschleißheim, Germany","Konrad, R., These authors contributed equally to this work, Public Health Microbiology Unit, Bavarian Health and Food Safety Authority, Oberschleißheim, Germany; Eberle, U., These authors contributed equally to this work, Unit of Virology, Bavarian Health and Food Safety Authority, Oberschleißheim, Germany; Dangel, A., These authors contributed equally to this work, Public Health Microbiology Unit, Bavarian Health and Food Safety Authority, Oberschleißheim, Germany; Treis, B., Unit of Virology, Bavarian Health and Food Safety Authority, Oberschleißheim, Germany; Berger, A., Public Health Microbiology Unit, Bavarian Health and Food Safety Authority, Oberschleißheim, Germany; Bengs, K., Public Health Microbiology Unit, Bavarian Health and Food Safety Authority, Oberschleißheim, Germany; Fingerle, V., Unit of Virology, Bavarian Health and Food Safety Authority, Oberschleißheim, Germany; Liebl, B., Ludwig Maximilians-Universität, Munich, Germany, State Institute of Health, Bavarian Health and Food Safety Authority, Oberschleißheim, Germany; Ackermann, N., These authors contributed equally to this work, Unit of Virology, Bavarian Health and Food Safety Authority, Oberschleißheim, Germany; Sing, A., These authors contributed equally to this work, Public Health Microbiology Unit, Bavarian Health and Food Safety Authority, Oberschleißheim, Germany, Ludwig Maximilians-Universität, Munich, Germany","The need for timely establishment of diagnostic assays arose when Germany was confronted with the first travel-associated outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Europe. We describe our laboratory experiences during a large contact tracing investigation, comparing previously published real-time RT-PCR assays in different PCR systems and a commercial kit. We found that assay performance using the same primers and probes with different PCR systems varied and the commercial kit performed well.",Corona Virus; COVID-19; Infectious disease; Laboratory Diagnostics; Molecular Testing; outbreaks; Real-Time PCR; SARS-CoV-2,"COVID-19; severe acute respiratory syndrome coronavirus 2; virus envelope protein; Betacoronavirus; Coronavirus infection; DNA microarray; genetics; Germany; human; isolation and purification; procedures; real time polymerase chain reaction; sensitivity and specificity; time factor; virus pneumonia; workflow; Betacoronavirus; Coronavirus Infections; Germany; Humans; Oligonucleotide Array Sequence Analysis; Pneumonia, Viral; Real-Time Polymerase Chain Reaction; Sensitivity and Specificity; Time Factors; Viral Envelope Proteins; Workflow",,,,NLM (Medline),15607917,,,32156330,English,Euro Surveill.,Article,Final,Open Access,Scopus,2-s2.0-85081655719,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Pfefferle S., Reucher S., Nörz D., Lütgehetmann M.",15848739600;57208223775;55926631200;13404018500;,Evaluation of a quantitative RT-PCR assay for the detection of the emerging coronavirus SARS-CoV-2 using a high throughput system,2020,Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin,25,9,,,,,,10.2807/1560-7917.ES.2020.25.9.2000152,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081643652&doi=10.2807%2f1560-7917.ES.2020.25.9.2000152&partnerID=40&md5=4b2765f97dbe96449b395e4c71643493,"Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf (UKE)Hamburg, Germany","Pfefferle, S., Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf (UKE)Hamburg, Germany; Reucher, S., Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf (UKE)Hamburg, Germany; Nörz, D., Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf (UKE)Hamburg, Germany; Lütgehetmann, M., Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf (UKE)Hamburg, Germany","Facing the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), high-volume respiratory testing is demanded in laboratories worldwide. We evaluated the performance of a molecular assay for the detection of SARS-CoV-2 on a high-throughput platform, the cobas 6800, using the 'open channel' for integration of a laboratory-developed assay. We observed good analytical performance in clinical specimens. The fully automated workflow enables high-throughput testing with minimal hands-on time, while offering fast and reliable results.",automation; COVID-19; high-throughput PCR; molecular diagnostic; SARS-CoV-2,severe acute respiratory syndrome coronavirus 2; Betacoronavirus; Coronavirinae; human; reverse transcription polymerase chain reaction; SARS coronavirus; sensitivity and specificity; severe acute respiratory syndrome; Betacoronavirus; Coronavirus; Humans; Reverse Transcriptase Polymerase Chain Reaction; SARS Virus; Sensitivity and Specificity; Severe Acute Respiratory Syndrome,,,,NLM (Medline),15607917,,,32156329,English,Euro Surveill.,Note,Final,Open Access,Scopus,2-s2.0-85081643652,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Lin X., Gong Z., Xiao Z., Xiong J., Fan B., Liu J.",57215085349;57215097522;57215095212;57215087734;57215081757;57215097841;,Novel coronavirus pneumonia outbreak in 2019: Computed tomographic findings in two cases,2020,Korean Journal of Radiology,21,3,,365,368,,8,10.3348/kjr.2020.0078,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079894245&doi=10.3348%2fkjr.2020.0078&partnerID=40&md5=26d03625a546a20c01934d0c5f6e6909,"Departments of Radiology, Jiangxi Provincial People’s HospitalJiangxi, China; Departments of Prevention and Health Care, Jiangxi Provincial People’s HospitalJiangxi, China; Departments of Respiratory, Jiangxi Provincial People’s HospitalJiangxi, China; Department of Radiology, Jiangxi Chest HospitalJiangxi, China","Lin, X., Departments of Radiology, Jiangxi Provincial People’s HospitalJiangxi, China; Gong, Z., Departments of Prevention and Health Care, Jiangxi Provincial People’s HospitalJiangxi, China; Xiao, Z., Departments of Respiratory, Jiangxi Provincial People’s HospitalJiangxi, China; Xiong, J., Department of Radiology, Jiangxi Chest HospitalJiangxi, China; Fan, B., Departments of Radiology, Jiangxi Provincial People’s HospitalJiangxi, China; Liu, J., Departments of Radiology, Jiangxi Provincial People’s HospitalJiangxi, China","Since the 2019 novel coronavirus (2019-nCoV or officially named by the World Health Organization as COVID-19) outbreak in Wuhan, Hubei Province, China in 2019, there have been a few reports of its imaging findings. Here, we report two confirmed cases of 2019-nCoV pneumonia with chest computed tomography findings of multiple regions of patchy consolidation and ground-glass opacities in both lungs. These findings were characteristically located along the bronchial bundle or subpleural lungs. © 2020 The Korean Society of Radiology.",2019 novel coronavirus; Computed tomography; Severe acute respiratory infection,"C reactive protein; glucose; virus DNA; COVID-19; 2019 novel coronavirus; adult; Article; aspartate aminotransferase blood level; case report; clinical article; computer assisted tomography; coronavirus disease 2019; coughing; fever; gene amplification; human; hyperglycemia; lymphocyte count; male; neutrophil count; physical examination; real time polymerase chain reaction; reverse transcription polymerase chain reaction; sputum analysis; throat disease; virus pneumonia; bronchus; China; Coronavirus infection; diagnostic imaging; epidemic; fever; lung; pathology; procedures; thorax radiography; virus pneumonia; World Health Organization; x-ray computed tomography; Adult; Bronchi; China; Coronavirus Infections; Disease Outbreaks; Fever; Humans; Lung; Male; Pneumonia, Viral; Radiography, Thoracic; Tomography, X-Ray Computed; World Health Organization","Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, , https://doi.org/10.1056/NEJMoa2001017; Chen, Y., Liu, Q., Guo, D., Coronaviruses: Genome structure, replication, and pathogenesis (2020) J Med Virol, , https://doi.org/10.1002/jmv.25681; Lu, H., Stratton, C.W., Tang, Y.W., Outbreak of pneumonia of unknown etiology in Wuhan China: The mystery and the miracle (2020) J Med Virol, , https://doi.org/10.1002/jmv.25678; Choi, W.J., Lee, K.N., Kang, E.J., Lee, H., Middle East respiratory syndrome-coronavirus infection: A case report of serial computed tomographic findings in a young male patient (2016) Korean J Radiol, 17, pp. 166-170; Note from the editors: Novel coronavirus (2019-nCoV) (2020) Euro Surveill, 25; Corman, V.M., Landt, O., Kaiser, M., Molenkamp, R., Meijer, A., Chu, D.K., Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR (2020) Euro Surveill, 25; Gralinski, L.E., Menachery, V.D., Return of the coronavirus: 2019-nCoV (2020) Viruses, 12; Emerging understandings of 2019-nCoV (2020) The Lancet., 395, p. 311; Rubin, E.J., Baden, L.R., Morrissey, S., Campion, E.W., Medical journals and the 2019-nCoV outbreak (2020) N Engl J Med, , https://doi.org/10.1056/NEJMe2001329; Hui, D.S., I Azhar, E., Madani, T.A., Ntoumi, F., Kock, R., Dar, O., The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health-The latest 2019 novel coronavirus outbreak in Wuhan, China (2020) Int J Infect Dis, 91, pp. 264-266; Ooi, G.C., Khong, P.L., Müller, N.L., Yiu, W.C., Zhou, L.J., Ho, J.C., Severe acute respiratory syndrome: Temporal lung changes at thin-section CT in 30 patients (2004) Radiology, 230, pp. 836-844; Müller, N.L., Ooi, G.C., Khong, P.L., Zhou, L.J., Tsang, K.W., Nicolaou, S., High-resolution CT findings of severe acute respiratory syndrome at presentation and after admission (2004) AJR am J Roentgenol, 182, pp. 39-44","Fan, B.; Department of Radiology, Jiangxi Provincial People’s Hospital, 92 Aiguo Rd, Donghu, China; email: 26171381@qq.com",,Korean Radiological Society,12296929,,,32056397,English,Korean J. Radiol.,Article,Final,,Scopus,2-s2.0-85079894245,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, [No author name available],[No author id available],"Correction to Game consumption and the 2019 novel coronavirus (The Lancet Infectious Diseases (2020) 20(3) (275–276), (S1473309920300633), (10.1016/S1473-3099(20)30063-3))",2020,The Lancet Infectious Diseases,20,3,,e27,,,,10.1016/S1473-3099(20)30071-2,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079893796&doi=10.1016%2fS1473-3099%2820%2930071-2&partnerID=40&md5=c64ebf33e962b83b6ceb01194f9ce522,,,"Li J, Li J(J), Xie X, et al. Game consumption and the 2019 novel coronavirus. Lancet Infect Dis 2020; 20: 275–76—In this Comment, the date by which the wet market in Wuhan was closed after linkage to severe pneumonia was changed to Jan 1, 2020. Additionally, Jun (Justin) Li's name was amended to the correct spelling. These corrections have been made to the online version as of Feb 26, 2020, and the printed version is correct. © 2020 Elsevier Ltd",,erratum,,,,Lancet Publishing Group,14733099,,LIDAB,,English,Lancet Infect. Dis.,Erratum,Final,Open Access,Scopus,2-s2.0-85079893796,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Yu F., Du L., Ojcius D.M., Pan C., Jiang S.",57085672500;8686996200;7006458588;24491970300;56491898300;,"Measures for diagnosing and treating infections by a novel coronavirus responsible for a pneumonia outbreak originating in Wuhan, China",2020,Microbes and Infection,22,2,,74,79,,4,10.1016/j.micinf.2020.01.003,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079131599&doi=10.1016%2fj.micinf.2020.01.003&partnerID=40&md5=4752634686dd0d8363a297bcf81cadcc,"The College of Life and Sciences, Hebei Agricultural University, Bao Ding, China; Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, United States; Department of Biomedical Sciences, University of the Pacific, School of Dentistry, San Francisco, United States; Guangdong Haid Institute of Animal Husbandry & Veterinary, Haid Research Institute, Guangdong Haid Group Co., Ltd, Guangzhou, China; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Fudan University, Shanghai, China","Yu, F., The College of Life and Sciences, Hebei Agricultural University, Bao Ding, China; Du, L., Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, United States; Ojcius, D.M., Department of Biomedical Sciences, University of the Pacific, School of Dentistry, San Francisco, United States; Pan, C., Guangdong Haid Institute of Animal Husbandry & Veterinary, Haid Research Institute, Guangdong Haid Group Co., Ltd, Guangzhou, China; Jiang, S., Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, United States, Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Fudan University, Shanghai, China","On 10 January 2020, a new coronavirus causing a pneumonia outbreak in Wuhan City in central China was denoted as 2019-nCoV by the World Health Organization (WHO). As of 24 January 2020, there were 887 confirmed cases of 2019-nCoV infection, including 26 deaths, reported in China and other countries. Therefore, combating this new virus and stopping the epidemic is a matter of urgency. Here, we focus on advances in research and development of fast diagnosis methods, as well as potential prophylactics and therapeutics to prevent or treat 2019-nCoV infection. © 2020 Institut Pasteur",2019-nCoV; Diagnosis; Preventive; Therapeutic,"antivirus agent; neutralizing antibody; virus fusion inhibitor; virus vaccine; antivirus agent; coronavirus spike glycoprotein; COVID-19; severe acute respiratory syndrome coronavirus 2; virus antibody; virus RNA; virus vaccine; 2019 novel coronavirus; antibody detection; Article; China; Coronavirus infection; epidemic; human; nonhuman; pneumonia; priority journal; prophylaxis; virus replication; World Health Organization; amino acid sequence; Betacoronavirus; Coronavirus infection; epidemiology; immunology; isolation and purification; nucleic acid amplification; pathogenicity; sequence alignment; virus pneumonia; Amino Acid Sequence; Antibodies, Neutralizing; Antibodies, Viral; Antiviral Agents; Betacoronavirus; China; Coronavirus Infections; Humans; Nucleic Acid Amplification Techniques; Pneumonia, Viral; RNA, Viral; Sequence Alignment; Spike Glycoprotein, Coronavirus; Viral Vaccines","https://www.who.int/emergencies/en/; Chan, K.H., Chan, J.F., Tse, H., Chen, H., Lau, C.C., Cai, J.P., Cross-reactive antibodies in convalescent SARS patients’ sera against the emerging novel human coronavirus EMC (2012) by both immunofluorescent and neutralizing antibody tests (2013) J Infect, 67, pp. 130-140; Aburizaiza, A.S., Mattes, F.M., Azhar, E.I., Hassan, A.M., Memish, Z.A., Muth, D., Investigation of anti-middle East respiratory syndrome antibodies in blood donors and slaughterhouse workers in Jeddah and Makkah, Saudi Arabia, fall 2012 (2014) J Infect Dis, 209, pp. 243-246; Reusken, C., Mou, H., Godeke, G.J., van der Hoek, L., Meyer, B., Muller, M.A., Specific serology for emerging human coronaviruses by protein microarray (2013) Euro Surveill, 18, p. 20441; Zhao, G., Du, L., Ma, C., Li, Y., Li, L., Poon, V.K., A safe and convenient pseudovirus-based inhibition assay to detect neutralizing antibodies and screen for viral entry inhibitors against the novel human coronavirus MERS-CoV (2013) Virol J, 10, p. 266; Lu, H., Stratton, C.W., Tang, Y.W., Outbreak of pneumonia of unknown etiology in Wuhan China: the mystery and the miracle (2020) J Med Virol, 92. , [:???-???]; https://www.who.int/docs/default-source/coronaviruse/clinical-management-of-novel-cov.pdf?sfvrsn=bc7da517_2, WHO:; https://www.who.int/docs/default-source/coronaviruse/20200114-interim-laboratory-guidance-version.pdf?sfvrsn=6967c39b_4&download=true, WHO:; https://www.gisaid.org/; http://virological.org/t/initial-assessment-of-the-ability-of-published-coronavirus-primers-sets-to-detect-the-wuhan-coronavirus/321; Noh, J.Y., Yoon, S.W., Kim, D.J., Lee, M.S., Kim, J.H., Na, W., Simultaneous detection of severe acute respiratory syndrome, Middle East respiratory syndrome, and related bat coronaviruses by real-time reverse transcription PCR (2017) Arch Virol, 162, pp. 1617-1623; Go, Y.Y., Kim, Y.S., Cheon, S., Nam, S., Ku, K.B., Kim, M., Evaluation and clinical validation of two field-deployable reverse transcription-insulated isothermal PCR assays for the detection of the Middle East respiratory syndrome-coronavirus (2017) J Mol Diagn, 19, pp. 817-827; 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Loutfy, M.R., Blatt, L.M., Siminovitch, K.A., Ward, S., Wolff, B., Lho, H., Interferon alfacon-1 plus corticosteroids in severe acute respiratory syndrome: a preliminary study (2003) JAMA, 290, pp. 3222-3228; Belshaw, R., Gardner, A., Rambaut, A., Pybus, O.G., Pacing a small cage: mutation and RNA viruses (2008) Trends Ecol Evol, 23, pp. 188-193","Pan, C.; Haid Research Institute, Guangdong Haid Group Co., Ltd, 5 Eighth Street, Fu Ping Road, China; email: chungenp@163.com",,Elsevier Masson SAS,12864579,,MCINF,32017984,English,Microbes Infect.,Article,Final,Open Access,Scopus,2-s2.0-85079131599,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Cruvinel L.B., Ayres H., Zapa D.M.B., Nicaretta J.E., Couto L.F.M., Heller L.M., Bastos T.S.A., Cruz B.C., Soares V.E., Teixeira W.F., de Oliveira J.S., Fritzen J.T., Alfieri A.A., Freire R.L., Lopes W.D.Z.",57194208131;25722902100;57202680856;57191993123;57201668729;57211606227;57189048078;55795562300;8722417400;36605318800;57209510420;26647394900;56216806200;7004855531;15839956800;,"Prevalence and risk factors for agents causing diarrhea (Coronavirus, Rotavirus, Cryptosporidium spp., Eimeria spp., and nematodes helminthes) according to age in dairy calves from Brazil",2020,Tropical Animal Health and Production,52,2,,777,791,,,10.1007/s11250-019-02069-9,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85074606638&doi=10.1007%2fs11250-019-02069-9&partnerID=40&md5=85e996b32a65a8c8ebc8c894f104fd02,"Centro de Parasitologia Veterinária - CPV, Escola de Veterinária e Zootecnia, Universidade Federal de Goiás (UFG), Goiânia, GO, Brazil; MSD Saúde Animal, São Paulo, Brazil; Faculdade de Ciências Agrárias e Veterinárias, UNESP/CPPAR, Jaboticabal, São Paulo, Brazil; Universidade Brasil – Campus de Descalvado, São Paulo, SP, Brazil; Universidade Estadual de Londrina, Londrina, Brazil; Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, GO 74605050, Brazil","Cruvinel, L.B., Centro de Parasitologia Veterinária - CPV, Escola de Veterinária e Zootecnia, Universidade Federal de Goiás (UFG), Goiânia, GO, Brazil; Ayres, H., MSD Saúde Animal, São Paulo, Brazil; Zapa, D.M.B., Centro de Parasitologia Veterinária - CPV, Escola de Veterinária e Zootecnia, Universidade Federal de Goiás (UFG), Goiânia, GO, Brazil; Nicaretta, J.E., Centro de Parasitologia Veterinária - CPV, Escola de Veterinária e Zootecnia, Universidade Federal de Goiás (UFG), Goiânia, GO, Brazil; Couto, L.F.M., Centro de Parasitologia Veterinária - CPV, Escola de Veterinária e Zootecnia, Universidade Federal de Goiás (UFG), Goiânia, GO, Brazil; Heller, L.M., Centro de Parasitologia Veterinária - CPV, Escola de Veterinária e Zootecnia, Universidade Federal de Goiás (UFG), Goiânia, GO, Brazil; Bastos, T.S.A., Centro de Parasitologia Veterinária - CPV, Escola de Veterinária e Zootecnia, Universidade Federal de Goiás (UFG), Goiânia, GO, Brazil; Cruz, B.C., Faculdade de Ciências Agrárias e Veterinárias, UNESP/CPPAR, Jaboticabal, São Paulo, Brazil; Soares, V.E., Universidade Brasil – Campus de Descalvado, São Paulo, SP, Brazil; Teixeira, W.F., Centro de Parasitologia Veterinária - CPV, Escola de Veterinária e Zootecnia, Universidade Federal de Goiás (UFG), Goiânia, GO, Brazil; de Oliveira, J.S., Universidade Estadual de Londrina, Londrina, Brazil; Fritzen, J.T., Universidade Estadual de Londrina, Londrina, Brazil; Alfieri, A.A., Universidade Estadual de Londrina, Londrina, Brazil; Freire, R.L., Universidade Estadual de Londrina, Londrina, Brazil; Lopes, W.D.Z., Centro de Parasitologia Veterinária - CPV, Escola de Veterinária e Zootecnia, Universidade Federal de Goiás (UFG), Goiânia, GO, Brazil, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, GO 74605050, Brazil","The present study attempted to verify the prevalence of and risk factors for diarrhea-causing agents in dairy calves from Brazil. Additionally, ages with a higher risk of occurrence for each agent were verified by means of the receiver operating characteristic (ROC) curve. The collections were performed on 39 farms, belonging to 29 municipalities located in eight states of Brazil. It was possible to conclude that the prevalence of Coronavirus, Rotavirus, Cryptosporidium spp., Eimeria spp., and nematodes was 7.20% (95% CI 4.54–9.78), 6.37% (95% CI 3.85–8.89), 51.52% (95% CI 45.26–55.57), 3.46% (95% CI 2.24–4.67), and 3.46% (95% CI 2.24–4.67), respectively. Ages with higher probabilities of occurrence of these diseases in calves were < 10, > 8, > 6, > 37, and > 36 days, respectively. Diarrhea occurred more significantly (P < 0.0001) in animals less than 21 days old and mainly on those receiving milk through automatic feeders (P < 0.001). Cryptosporidium spp. were a risk factor for the occurrence of Rotavirus, and vice versa (P = 0.0039) and presented a positive correlation with Coronavirus (P = 0.0089). Calves that drink water from rivers, streams, and ponds had a higher chance of being infected by Eimeria spp. (P < 0.0001), as well as developing infection by nematodes (P < 0.0001). The results found in this study highlight the importance of studying the agents of diarrhea together, once they act as coinfection where the losses triggered for the owners will involve some of these agents simultaneously. © 2019, Springer Nature B.V.",Coronavirus; Cryptosporidium spp; Diarrhea; Eimeria spp; Nematodes; Rotavirus,,"Alfieri, A.A., Leite, J.P., Alfieri, A.F., Jiang, B., Glass, R.I., Gentsch, J.R., Detection of field isolates of human and animal group C rotavirus by reverse transcription-polymerase chain reaction anddigoxigenin-labeled oligonucleotide probes (1999) Journal Virology Methods, 83, pp. 35-43. , COI: 1:CAS:528:DC%2BD3cXhslWi; Alfieri, A.A., Parazzi, M.E., Takiuchi, E., Medici, K.C., Alfieri, A.F., Frequency of group A rotavirus in diarrhoeic calves in Brazilian cattle herds, 1998–2002 (2006) Tropical Animal Health Production, 38, pp. 521-526. , COI: 1:STN:280:DC%2BD2s%2FmtFGhuw%3D%3D; Almeida, P.R., Lorenzetti, F., Cruz, R.S., Watanabe, T.T., Zlotowiski, P., Dremeier, D., Diarrhea caused by rotavirus A, B, and C in suckling piglets from southern Brazil: molecular detection and histologic and immunohistochemical characterization (2018) Journ of Veterinary Diagnostic Investigation, 30, pp. 370-376. , COI: 1:CAS:528:DC%2BC1cXpt1Kmt78%3D; Bok, M., Alassia, M., Frank, F., Vega, C.G., Wigdorovitz, A., Parreno, V., Passive immunity to control Bovine coronavirus diarrhea in a dairy herd in Argentina (2018) Revista Argentina de Microbiologia, 50, pp. 20-23; Bruhn, F.R.P., Lopes, M.A., Demeu, F.A., Perazza, C.A., Pedrosa, M.F., Guimarães, A.M., Frequency of species of Eimeria in females of the holstein-friesian breed at the post-weaning stage during autumn and winter (2011) Revista Brasileira de Parasitolologia Veterinaria, 20, pp. 303-307; Cardoso, J.M.S., Silveira, F.L., Araujo, A.J.U.S., Carvalho, J.C.C., Kanamura, H.Y., Ocorrência de Cryptosporidium spp. em um rebanho bovino leiteiro no município de Caçapava, estado de São Paulo (2008) Brasil, Revista Brasileira de Parasitologia Veterinária, 12, pp. 239-242; Coura, F.M., Freitas, M.D., Ribeiro, J., de Leme, R.A., de Souza, C., Alfieri, A.A., Facury Filho, E.J., Heinemann, M.B., Longitudinal study of Salmonella spp., diarrheagenic Escherichia coli, Rotavirus, and Coronavirus isolated from healthy and diarrheic calves in a Brazilian dairy herd (2015) Tropical Animal Health Production, 47, pp. 3-11; Cruvinel, L.B., Bastos, T.S.A., Nicaretta, J.E., Couto, L.F.M., Borges, D.G.L., Borges, F.A., Soares, V.E., Lopes, W.D.Z., Surtos consecutivos ocasionado por Eimeria zuernii em bezerros de corte de uma propriedade do estado de São Paulo (2018) Pesquisa Veterinária Brasileira, 38, pp. 277-284; Cruvinel, L.B., Nicaretta, J.E., Bastos, T.S.A., Couto, L.F.M., Santos, J.B., Zapa, D.M.B., Cavalcantes, A.S.A., Lopes, W.D.Z., Eimeria species in dairy and beef cattle of different ages in Goiás state, Brazil (2018) Revista Brasileira de Parasitologia Veterinária, 27, pp. 169-176; Daugschies, A., Najdrowski, M., Eimeriosis in cattle: current understanding (2005) Journal Veterinarian Medicine Infectious Disease Veterinary and Public Health, 52, pp. 417-427. , COI: 1:STN:280:DC%2BD2MnnslOntg%3D%3D; Elliot, A., Morgan, U.M., Thompson, R.C., Improved staining method for detecting Cryptosporidium oocysts in stools using malachite green (1999) The Journal of General and Applied Microbiology, 45, pp. 139-142. , COI: 1:CAS:528:DC%2BD3cXhs12iug%3D%3D; Feitosa, F.L.F., Schimamura, G.M., Roberto, T., Mendes, L.C.N., Peiró, J.R., Feres, F.C., Bovino, F., Meireles, M.V., Importância de Cryptosporidium spp. como causa de diarréia em bezerros (2008) Pesquisa Veterinária Brasileira, 28, pp. 452-456; Felippelli, G., Lopes, W.D.Z., Cruz, B.C., Teixeira, W.F.P., Maciel, W.G., Favero, F.C., Buzulini, C., Costa, A.J., Nematode resistance to ivermectin (630 and 700μg/kg) in cattle from the Southeast and South of Brazil (2014) Parasitology International, 63, pp. 835-840. , COI: 1:CAS:528:DC%2BC2cXhtlOrt7zF; Fritzen, J.T.T., Oliveria, V., Lorenzetti, E., Miyabe, F.M., Viziaki, M.P., Rodrigues, C.A., Ayres, H., Alfieri, A.A., Longitudinal surveillance of rotavirus A genotypes circulating in a high milk yield dairy cattle herd after the introduction of a rotavirus vaccine (2019) Veterinary Microbiology, 230, pp. 260-264; Galpasoro, L.U., Fernandéz, S.P., Curva roc (1998) Caderno Atenia Primaria, 5, pp. 229-235; Garcia, A.M., Lima, J.D., Freqüência do Cryptosporidiumem bezerros lactentes de rebanhos leiteiros de Minas Gerais (1994) Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 45, pp. 193-198; Gentsch, J.R., Glass, R.I., Woods, P., Gouvea, V., Gorziglia, M., Flores, J., Das, B.K., Bhan, M.K., Identification of group A rota-virus gene 4 types by polymerase chain reaction (1992) Journal of Clinical Microbiology, 30, pp. 1365-1373. , COI: 1:CAS:528:DyaK3sXnsVCiug%3D%3D; Gordon, H.M.L., Whitlock, H.V., A new technique for counting nematode eggs in sheep feces (1939) Journal Counsumition Science Industry Research, 12, pp. 50-52; Gouvea, V., Glass, R.I., Woods, P., Taniguchi, K., Clark, H.F., Forrester, B., Fang, Z.Y., Polymerase chain reaction amplification and typing of rotavirus nucleic acid fromstool specimens (1990) Journal of Clinical Microbiology, 28, pp. 276-282. , COI: 1:CAS:528:DyaK3cXhvFClsbY%3D; Gouvea, V., Allen, J.R., Glass, R.I., Fang, Z.Y., Bremont, M., Cohen, J., McCrae, M.A., Caul, E.O., Detection of group B and C rotaviruses by polymerase chain reaction (1991) Journal of Clinical Microbiology, 29, pp. 519-523. , COI: 1:STN:280:DyaK3M3ksV2rsA%3D%3D; Hayashi, M., Murakami, T., Fukuda, F.M., Tsuchiaka, S., Kishimoto, M., Sano, K., Asano, K., Nagai, M., Diversity in VP3, NSP3, and NSP4 of rotavirus B detected from Japanese cattle (2017) Infection, Genetics and Evolution, 49, pp. 107-113; Herring, A.J., Inglis, N.F., Ojeh, C.K., Snodgrass, D.R., Menzies, J.D., Rapid diagnosis of rotavirus infection by direct detection of viral nucleic acid in silver-stained polyacrylamide gels (1982) Journal Clinical Microbiology, 16, pp. 473-477. , COI: 1:CAS:528:DyaL38Xlslyhs7g%3D; (2017) Brazilian Institute of Geographic and Statistics, , https://sidra.ibge.gov.br/pesquisa/ppm/quadros/brasil/2017, IBGE, Acessed on 10 feb. 2017; Jerez, J.A., Brandão, P.E., Buzinaro, M.G., Gregori, F., Rosales, C.A.R., Ito, F.H., Sakai, T., Detecção derotavírus e coronavírus em fezes de bezerros neonatos com diarréia criados em vários municípios do estado de São Paulo, Brasil (2002) Arquivo do Instituto Biológico, 69, pp. 19-23; Langoni, H., Linhares, A.C., Avila, F.A., Silva, A.V., Elias, A.O., Contribuição ao estudo da etiologia das diarréias em bezerros de aptidão leiteira no Estado de São Paulo, Brasil (2004) Brazilian Journal of Veterinary Research and Animal Science, 41, pp. 313-319; Lucas, A.S., Swecker, S., Lindsay, D.S., Scagli, G., Neel, J.P.S., Elvinger, C., Zaja, A.M., A study of the level and dynamics of Eimeria populations innaturally infected, grazing beef cattle at various stages ofproduction in the Mid-Atlantic USA (2014) Veterinary Parasitology, 202, pp. 201-206; Malik, Y.S., Sharma, K., Vaid, N., Chakravarti, S., Chandrashekar, K.M., Basera, S.S., Frequency of group A rotavirus with mixed G and P genotypes in bovines: predominance of G3 genotype and its emergence in combination with G8/G10 types (2012) Journal of Veterinary Science, 3, pp. 271-278; Masatani, T., Ferei, R.M., Otomaru, K., Ishikawa, S., Kojima, I., Hobo, S., Nishikawa, Y., Seroprevalence of Cryptosporidium parvum and Neospora caninum in cattle in the southern Kyushu region of Japan (2018) Parasitology International, 63, pp. 763-767; Meireles, M.V., Cryptosporidium infection in Brazil: implications for veterinary medicine and public health (2010) Revista Brasileira de Parasitologia Veterinária, 19, pp. 197-204; Meloni, B.P., Thompson, R.C.A., Simplified methods for obtaining purified oocysts from mice and for growing Cryptosporidium parvum in vitro (1996) Journal of Parasitology, 82, pp. 757-762. , COI: 1:STN:280:DyaK2s%2FktVGksA%3D%3D; Murakoshi, F., Tozawa, Y., Inomata, A., Horimoto, T., Wada, Y., Kato, K., Molecular characterization of Cryptosporidium isolates from calves in Ishikari Distinct (2013) Hokkaido, Japan, Journal of Veterinary Medicine Science, 75, pp. 837-840; Passafaro, T.L., Carrera, J.P.B., Santos, L.L., Silva, F.S., Santos, D.C., Cardoso, E.P., Leite, R.C., Toral, F.L.B., Genetic analysis of resistance to ticks, gastrointestinal nematodes and Eimeria spp. in Nellore cattle (2015) Veterinary Parasitology, 210, pp. 224-234. , COI: 1:CAS:528:DC%2BC2MXlvVGqtLs%3D; Pereira, H.G., Azeredo, R.S., Leite, J.P., Candeias, J.A., Racz, M.L., Linhares, A.C., Electrophoretic study of the genome of human rotaviruses from Rio de Janeiro, Sao Paulo and Para, Brazil (1983) The Journal of Hygiene, 90, pp. 117-125. , COI: 1:CAS:528:DyaL3sXhsVShtr4%3D; Silva, F.D.F., Gregori, F., Gonçalves, A.C.S., Samara, S.I., Buzinaro, M.G., Molecular characterization of group A bovine rotavirus in southeastern and central-western Brazil, 2009-2010 (2012) Pesquisa Veterinaria Brasileira, 32, pp. 237-242; Souza, A.P., Ramos, C.I., Bellato, V., Sartor, A.A., Schelbauer, C.A., Resistência de helmintos gastrintestinais de bovinos a anti-helmínticos no Planalto Catarinense (2008) Ciência Rural, 38, pp. 1363-1367; Takiuchi, E., Stipp, D.T., Alfieri, A.F., Alfieri, A.A., Improved detection of bovine coronavirus N gene in faeces of calves infected naturally by a semi-nested PCR assay anda internal control (2006) Journal of Virology Methods, 131, pp. 148-154. , COI: 1:CAS:528:DC%2BD28XksVShug%3D%3D; Taubert, A., Hermosilla, C., Suhwold, A., Zahner, H., Antigen-induced cytokine production in lymphocytes of Eimeria bovis primary and challenge infected calves (2008) Veterinary Immunology and Immunopathology, 126, pp. 309-320. , COI: 1:CAS:528:DC%2BD1cXhsVWmtbfJ; Thomson, S., Hamilton, C.A., Hope, J.C., Katzer, F., Mabbott, N.A., Morrison, L.J., Innes, E.A., Bovine cryptosporidiosis: impact, host-parasite interaction and control strategies (2017) Veterinary Research, 48, p. 42; Tsunemitsu, H., Smith, D.R., Saif, L.J., Experimental inoculation of adult dairy cows with bovine coronavirus and detection of coronavirus in feces by RT-PCR (1999) Archives of Virology, 144, pp. 167-175. , COI: 1:CAS:528:DyaK1MXhsFSms7s%3D; Ueno, H., Gonçalves, P.C., (1998) Manual Para diagnóstico Das Helmintoses De Ruminantes, , 4 ed., Japan International Cooperation Agency; De Waele, V., Speybroeck, N., Berkvens, D., Mulcahy, G., Murphy, T.M., Control of cryptosporidiosis in neonatal calves: Use of halofuginone lactate in two different calf rearing systems (2010) Preventive Veterinary Medicine, 96 (3-4), pp. 143-151. , COI: 1:STN:280:DC%2BC3cjptlWgsw%3D%3D; (2015) Database and Statistics Software for Public Heath Professonals, , https://search.cdc.gov/search/?query=regression+logistic&utf8=%E2%9C%93&affiliate=cdc-main, World Health Organization, EPI INFO, Centers for Disease Control and Prevention (CDC) Version 7.1.5.2","Lopes, W.D.Z.; Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de GoiásBrazil; email: wdzlopes@hotmail.com",,Springer,494747,,TAHPA,31591674,English,Trop. Anim. Health Prod.,Article,Final,Open Access,Scopus,2-s2.0-85074606638,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Buonsenso D., Piano A., Raffaelli F., Bonadia N., de Gaetano Donati K., Franceschi F.",36607486700;57215865492;57215867267;57215867300;6602117937;7005989850;,Point-of-Care Lung Ultrasound findings in novel coronavirus disease-19 pnemoniae: a case report and potential applications during COVID-19 outbreak,2020,European review for medical and pharmacological sciences,24,5,,2776,2780,,,10.26355/eurrev_202003_20549,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082147065&doi=10.26355%2feurrev_202003_20549&partnerID=40&md5=194037aba22cf55f90250dd222218316,"Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy","Buonsenso, D., Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Piano, A.; Raffaelli, F.; Bonadia, N.; de Gaetano Donati, K.; Franceschi, F.","An outbreak of a novel coronavirus disease-19 (nCoV-19) infection began in December 2019 in Wuhan, China, and now involved the whole word. Several health workers have been infected in different countries. We report the case of a young man with documented nCoV-19 infection evaluated with lung ultrasound and discuss potential applications of lung ultrasound in this setting. Lung ultrasound allowed the identification of nCoV-19 infection at bed-side. Moreover, lung ultrasound can have several other advantages, such as reduced health worker exposition to infected patients, repeatability during follow-up, low-costs and easier application in low-resource settings.",,"Betacoronavirus; case report; Coronavirus infection; diagnostic imaging; echography; human; lung; male; middle aged; pandemic; point of care system; procedures; virus pneumonia; Betacoronavirus; Coronavirus Infections; Humans; Lung; Male; Middle Aged; Pandemics; Pneumonia, Viral; Point-of-Care Systems; Ultrasonography",,,,NLM (Medline),22840729,,,32196627,English,Eur Rev Med Pharmacol Sci,Article,Final,,Scopus,2-s2.0-85082147065,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Sheikh A., Al-Taher A., Al-Nazawi M., Al-Mubarak A.I., Kandeel M.",57212678992;6506090106;12765916000;23481404600;22937486100;,Analysis of preferred codon usage in the coronavirus N genes and their implications for genome evolution and vaccine design,2020,Journal of Virological Methods,277,,113806,,,,1,10.1016/j.jviromet.2019.113806,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077337183&doi=10.1016%2fj.jviromet.2019.113806&partnerID=40&md5=fb6d21dc0d2a9f1d06a679acfe65ca95,"The Camel Research Center, King Faisal University, Alhofuf, Alahsa 31982, Saudi Arabia; Department of Biomedical Sciences, College of Veterinary Medicine, King Faisal University, Alhofuf, Alahsa 31982, Saudi Arabia; Department of Microbiology, College of Veterinary Medicine, King Faisal University, Alhofuf, Alahsa 31982, Saudi Arabia; Department of Pharmacology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, 33516, Egypt","Sheikh, A., The Camel Research Center, King Faisal University, Alhofuf, Alahsa 31982, Saudi Arabia; Al-Taher, A., Department of Biomedical Sciences, College of Veterinary Medicine, King Faisal University, Alhofuf, Alahsa 31982, Saudi Arabia; Al-Nazawi, M., Department of Biomedical Sciences, College of Veterinary Medicine, King Faisal University, Alhofuf, Alahsa 31982, Saudi Arabia; Al-Mubarak, A.I., Department of Microbiology, College of Veterinary Medicine, King Faisal University, Alhofuf, Alahsa 31982, Saudi Arabia; Kandeel, M., Department of Biomedical Sciences, College of Veterinary Medicine, King Faisal University, Alhofuf, Alahsa 31982, Saudi Arabia, Department of Pharmacology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, 33516, Egypt","The nucleocapsid (N) protein of a coronavirus plays a crucial role in virus assembly and in its RNA transcription. It is important to characterize a virus at the nucleotide level to discover the virus's genomic sequence variations and similarities relative to other viruses that could have an impact on the functions of its genes and proteins. This entails a comprehensive and comparative analysis of the viral genomes of interest for preferred nucleotides, codon bias, nucleotide changes at the 3rd position (NT3s), synonymous codon usage and relative synonymous codon usage. In this study, the variations in the N proteins among 13 different coronaviruses (CoVs) were analysed at the nucleotide and amino acid levels in an attempt to reveal how these viruses adapt to their hosts relative to their preferred codon usage in the N genes. The results revealed that, overall, eighteen amino acids had different preferred codons and eight of these were over-biased. The N genes had a higher AT% over GC% and the values of their effective number of codons ranged from 40.43 to 53.85, indicating a slight codon bias. Neutrality plots and correlation analyses showed a very high level of GC3s/GC correlation in porcine epidemic diarrhea CoV (pedCoV), followed by Middle East respiratory syndrome-CoV (MERS CoV), porcine delta CoV (dCoV), bat CoV (bCoV) and feline CoV (fCoV) with r values 0.81, 0.68, -0.47, 0.98 and 0.58, respectively. These data implied a high rate of evolution of the CoV genomes and a strong influence of mutation on evolutionary selection in the CoV N genes. This type of genetic analysis would be useful for evaluating a virus's host adaptation, evolution and is thus of value to vaccine design strategies. © 2019 Elsevier B.V.",Amino acid; Codon bias; Coronavirus; Nucleocapsid protein; Preferred nucleotides,amino acid; nucleocapsid protein; nucleotide; virus vaccine; adaptation; amino acid sequence; Article; bat coronavirus; codon; controlled study; Coronavirinae; correlation analysis; drug design; Feline coronavirus; genetic analysis; molecular evolution; N gene; nonhuman; nucleotide sequence; porcine delta coronavirus; Porcine epidemic diarrhea virus; priority journal; virus cell interaction; virus genome; virus mutation,"Ahn, I., Jeong, B.J., Son, H.S., Comparative study of synonymous codon usage variations between the nucleocapsid and spike genes of coronavirus, and C-type lectin domain genes of human and mouse (2009) Exp. Mol. Med., 41, p. 746; Bahir, I., Fromer, M., Prat, Y., Linial, M., Viral adaptation to host: a proteome‐based analysis of codon usage and amino acid preferences (2009) Mol. Syst. Biol., 5, p. 311; Behura, S.K., Severson, D.W., Codon usage bias: causative factors, quantification methods and genome‐wide patterns: with emphasis on insect genomes (2013) Biol. Rev., 88, pp. 49-61; Berry, M., Manasse, T.-L., Tan, Y.-J., Fielding, B.C., Characterisation of human coronavirus-NL63 nucleocapsid protein (2012) Afr. J. Biotechnol., 11, pp. 13962-13968; Blanchard, E.G., Miao, C., Haupt, T.E., Anderson, L.J., Haynes, L.M., Development of a recombinant truncated nucleocapsid protein based immunoassay for detection of antibodies against human coronavirus OC43 (2011) J. Virol. Methods, 177, pp. 100-106; Cavanagh, D., The Coronavirus Surface Glycoprotein, the Coronaviridae (1995), pp. 73-113. , Springer; Chaney, J.L., Clark, P.L., Roles for synonymous codon usage in protein biogenesis (2015) Annu. Rev. 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Evol., 35, pp. 27-33; Zhou, T., Gu, W., Ma, J., Sun, X., Lu, Z., Analysis of synonymous codon usage in H5N1 virus and other influenza A viruses (2005) Biosystems, 81, pp. 77-86","Sheikh, A.; The Camel Research Center, King Faisal UniversitySaudi Arabia",,Elsevier B.V.,1660934,,JVMED,31911390,English,J. Virol. Methods,Article,Final,Open Access,Scopus,2-s2.0-85077337183,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Li C.-X., Wu B., Luo F., Zhang N.",57216085999;57216086627;57216087404;57194108539;,Clinical Study and CT Findings of a Familial Cluster of Pneumonia with Coronavirus Disease 2019 (COVID-19),2020,Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition,51,2,,155,158,,,10.12182/20200360107,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082561434&doi=10.12182%2f20200360107&partnerID=40&md5=e0fdc1b3d13d55052dac4f24e71a4d0e,"Department of Radiology, Chengdu Pubulic Health Clinical Center, Chengdu, 610000, China; Department of Radiology, West China Hospital, Sichuan University, Chengdu, 610041, China","Li, C.-X., Department of Radiology, Chengdu Pubulic Health Clinical Center, Chengdu, 610000, China; Wu, B., Department of Radiology, West China Hospital, Sichuan University, Chengdu, 610041, China; Luo, F., Department of Radiology, Chengdu Pubulic Health Clinical Center, Chengdu, 610000, China; Zhang, N., Department of Radiology, Chengdu Pubulic Health Clinical Center, Chengdu, 610000, China","We studied the epidemiological and clinical data collected from a family with 5 people, in which there were 3 family member diagnosed as coronavirus disease 2019 (COVID-19). We found that the first patient in this family had Wuhan city travel history. Close contact in daily life was the route of infection. The most common symptoms were fever, cough and weakness. Characteristic imaging changes were found with grass opacity (GGO), consolidation and septal thickening mainly distributed in peripheral and posterior area by thoracic CT scan in the 3 patients. The abnormality in laborotary test included lower white blood cell count, neutrophil count and lymphocyte count,increasing fibrinogen and C-reactive protein,decreasing myohaemoglobin and increasing lactate dehydrogenase. The epidemiological and clinical features could provide quicker diagnosis and better management for the COVID-19 infected patients. Copyright© by Editorial Board of Journal of Sichuan University (Medical Science Edition).",Coronavirus disease 2019; CT; Familial cluster,,,,,NLM (Medline),1672173X,,,32220181,Chinese,Sichuan Da Xue Xue Bao Yi Xue Ban,Article,Final,,Scopus,2-s2.0-85082561434,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wang Y., Zhou C.-C., Shu R., Zou J.",56197387500;57216087297;57216086233;57215615924;,Oral Health Management of Children during the Epidemic Period of Coronavirus Disease 2019,2020,Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition,51,2,,151,154,,,10.12182/20200360101,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082562087&doi=10.12182%2f20200360101&partnerID=40&md5=bff014c8ca8d04495aa38a88c9cd75a1,"State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China","Wang, Y., State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China; Zhou, C.-C., State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China; Shu, R., State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China; Zou, J., State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China","Coronavirus disease 2019 (COVID-19) is becoming a major public health event affecting China and even the whole world. During the epidemic period of corona virus disease, appropriate oral health management and disease prevention of children is very important for children's oral and general health. In order to prevent the occurrence of cross-infection and epidemic spreading of COVID-19 during dental practice, the recommendations to parents include: not only training children to maintain hand hygiene at home, exercise appropriately, strengthen physical resistance, but also helping children develop good oral and diet habit such as effective brushing and flossing to avoid oral diseases and emergency. If non-emergency oral situation occur, parents could assist their child to take home based care such as rinsing to relieve the symptoms. When oral emergencies such as acute pulpitis, periapical periodontitis, dental trauma, oral and maxillofacial infections happen, parents and children should visit dental clinic in time with correct personal protection. During the epidemic period, children's oral emergencies should be treated in accordance with current guidelines and control of COVID-19. Copyright© by Editorial Board of Journal of Sichuan University (Medical Science Edition).",Children; Coronavirus disease 2019; Oral emergency; Oral health management,,,,,NLM (Medline),1672173X,,,32220180,Chinese,Sichuan Da Xue Xue Bao Yi Xue Ban,Review,Final,,Scopus,2-s2.0-85082562087,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Khot W.Y., Nadkar M.Y.",57193807177;6603397836;,The 2019 Novel Coronavirus Outbreak - A Global Threat,2020,The Journal of the Association of Physicians of India,68,3,,67,71,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081531589&partnerID=40&md5=1edf3d361e61efdb8cd0e89ada8cd80e,"Assistant Professor; Professor and Head, Department of Medicine, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India","Khot, W.Y., Assistant Professor; Nadkar, M.Y., Professor and Head, Department of Medicine, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India","The 2019 Novel Corona virus infection (COVID 19) is an ongoing public health emergency of international significance. There are significant knowledge gaps in the epidemiology, transmission dynamics, investigation tools and management. In this article, we review the available evidence about this disease. Every decade has witnessed the evolution of a new coronavirus epidemic since the last three decades. The varying transmission patterns, namely, nosocomial transmission and spread through mildly symptomatic cases is an area of concern. There is a spectrum of clinical features from mild to severe life threatening disease with major complications like severe pneumonia, ARDS, acute cardiac injury and septic shock. Presence of bilateral ground glass opacity and consolidation on imaging in appropriate clinical background should raise a suspicion about COVID 19. Poor prognostic factors include Multilobular infiltration on chest imaging, Lymphopenia, Bacterial co-infection, Smoking history, Chronic medical conditions like Hypertension and age >60 years (MuLBSTA score). Diagnosis is confirmed with PCR based testing of appropriate respiratory samples. Management is primarily supportive, with newer antivirals (lopinavir ritonavir and Remdesivir) under investigation. Role of steroids is still inconclusive. Standard infection control and prevention techniques should be followed. Vigilant screening of suspected cases and their contacts is important. Isolation of symptomatic cases and home quarantine of asymptomatic contacts is recommended. To conclude, controlling this highly transmissible disease requires international co-ordination. © Journal of the Association of Physicians of India 2011.",,severe acute respiratory syndrome coronavirus 2; Betacoronavirus; Coronavirinae; Coronavirus infection; epidemic; human; Betacoronavirus; Coronavirus; Coronavirus Infections; Disease Outbreaks; Humans,,,,NLM (Medline),45772,,,32138488,English,J Assoc Physicians India,Article,Final,,Scopus,2-s2.0-85081531589,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhou Y., Yang G.-D., Feng K., Huang H., Yun Y.-X., Mou X.-Y., Wang L.-F.",57215893245;57215895294;57215893747;57215894823;57215894500;57215893521;57215893525;,Clinical features and chest CT findings of coronavirus disease 2019 in infants and young children,2020,Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics,22,3,,215,220,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082290668&partnerID=40&md5=eea65b64c89929cccaa026b61ca9271f,"Department of Radiology, Shenzhen Third People's Hospital/National Clinical Research Center for Infectious Diseases/Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong 518100, China","Zhou, Y., Department of Radiology, Shenzhen Third People's Hospital/National Clinical Research Center for Infectious Diseases/Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong 518100, China; Yang, G.-D.; Feng, K.; Huang, H.; Yun, Y.-X.; Mou, X.-Y.; Wang, L.-F.","OBJECTIVE: To study the clinical features and chest CT findings of coronavirus disease 2019 (COVID-19) in infants and young children. METHODS: A retrospective analysis was performed for the clinical data and chest CT images of 9 children, aged 0 to 3 years, who were diagnosed with COVID-19 by nucleic acid detection between January 20 and February 10, 2020. RESULTS: All 9 children had an epidemiological history, and family clustering was observed for all infected children. Among the 9 children with COVID-19, 5 had no symptoms, 4 had fever, 2 had cough, and 1 had rhinorrhea. There were only symptoms of the respiratory system. Laboratory examination showed no reductions in leukocyte or lymphocyte count. Among the 9 children, 6 had an increase in lymphocyte count and 2 had an increase in leukocyte count. CT examination showed that among the 9 children, 8 had pulmonary inflammation located below the pleura or near the interlobar fissure and 3 had lesions distributed along the bronchovascular bundles. As for the morphology of the lesions, 6 had nodular lesions and 7 had patchy lesions; ground glass opacity with consolidation was observed in 6 children, among whom 3 had halo sign, and there was no typical paving stone sign. CONCLUSIONS: Infants and young children with COVID-19 tend to have mild clinical symptoms and imaging findings not as typical as those of adults, and therefore, the diagnosis of COVID-19 should be made based on imaging findings along with epidemiological history and nucleic acid detection. Chest CT has guiding significance for the early diagnosis of asymptomatic children.",,"Betacoronavirus; Coronavirus infection; diagnostic imaging; human; infant; newborn; preschool child; retrospective study; virus pneumonia; x-ray computed tomography; Betacoronavirus; Child, Preschool; Coronavirus Infections; Humans; Infant; Infant, Newborn; Pneumonia, Viral; Retrospective Studies; Tomography, X-Ray Computed",,,,NLM (Medline),10088830,,,32204756,Chinese,Zhongguo Dang Dai Er Ke Za Zhi,Article,Final,,Scopus,2-s2.0-85082290668,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Yu H., Sun X., Solvang W.D., Zhao X.",55608378800;57193124837;8647828300;57030728600;,Reverse logistics network design for effective management of medical waste in epidemic outbreaks: Insights from the coronavirus disease 2019 (COVID-19) outbreak in Wuhan (China),2020,International Journal of Environmental Research and Public Health,17,5,1770,,,,,10.3390/ijerph17051770,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081591255&doi=10.3390%2fijerph17051770&partnerID=40&md5=1869bca0dbd7548fa2bd87bc4ba026be,"Department of Industrial Engineering, UiT The Arctic University of Norway, Lodve Langesgate 2, Narvik, 8514, Norway; School of Economics and Management, China Three Gorges University, Yichang, 443002, China","Yu, H., Department of Industrial Engineering, UiT The Arctic University of Norway, Lodve Langesgate 2, Narvik, 8514, Norway; Sun, X., Department of Industrial Engineering, UiT The Arctic University of Norway, Lodve Langesgate 2, Narvik, 8514, Norway; Solvang, W.D., Department of Industrial Engineering, UiT The Arctic University of Norway, Lodve Langesgate 2, Narvik, 8514, Norway; Zhao, X., School of Economics and Management, China Three Gorges University, Yichang, 443002, China","The outbreak of an epidemic disease may pose significant treats to human beings and may further lead to a global crisis. In order to control the spread of an epidemic, the effective management of rapidly increased medical waste through establishing a temporary reverse logistics system is of vital importance. However, no research has been conducted with the focus on the design of an epidemic reverse logistics network for dealing with medical waste during epidemic outbreaks, which, if improperly treated, may accelerate disease spread and pose a significant risk for both medical staffs and patients. Therefore, this paper proposes a novel multi-objective multi-period mixed integer program for reverse logistics network design in epidemic outbreaks, which aims at determining the best locations of temporary facilities and the transportation strategies for effective management of the exponentially increased medical waste within a very short period. The application of the model is illustrated with a case study based on the outbreak of the coronavirus disease 2019 (COVID-19) in Wuhan, China. Even though the uncertainty of the future COVID-19 spread tendency is very high at the time of this research, several general policy recommendations can still be obtained based on computational experiments and quantitative analyses. Among other insights, the results suggest installing temporary incinerators may be an effective solution for managing the tremendous increase of medical waste during the COVID-19 outbreak in Wuhan, but the location selection of these temporary incinerators is of significant importance. Due to the limitation on available data and knowledge at present stage, more real-world information are needed to assess the effectiveness of the current solution. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.",Epidemic logistics; Epidemic outbreak; Medical waste; Network design; Operations research; Reverse logistics,"environmental policy; epidemiology; medical geography; network design; research work; risk assessment; solid waste; transportation system; waste facility; waste management; Article; case study; China; computer analysis; controlled study; coronavirus disease 2019; Coronavirus infection; hospital waste; incinerator; intermethod comparison; mathematical model; policy; quantitative analysis; research; reverse logistics network; traffic and transport; uncertainty; waste disposal facility; waste management; Betacoronavirus; Coronavirus infection; epidemic; human; problem solving; procedures; system analysis; virus pneumonia; waste disposal; waste management; China; Hubei; Wuhan; Coronavirus; COVID-19; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; China; Coronavirus Infections; Disease Outbreaks; Epidemics; Humans; Medical Waste; Medical Waste Disposal; Operations Research; Pneumonia, Viral; Problem Solving; Uncertainty; Waste Management","Boonmee, C., Arimura, M., Asada, T., Facility location optimization model for emergency humanitarian logistics (2017) Int. 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J. Environ. Res. Public Health,Article,Final,Open Access,Scopus,2-s2.0-85081591255,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Goo J., Jeong Y., Park Y.-S., Yang E., Jung D.-I., Rho S., Park U., Sung H., Park P.-G., Choi J.-A., Seo S.H., Cho N.H., Lee H., Lee J.M., Kim J.-O., Song M.",57194407178;57214129084;57214128218;56942142200;55106276700;57194409143;57201359704;57214123185;56763429400;55190294400;57214863130;34973855600;57214116894;57211144216;7601385099;35082687100;,Characterization of novel monoclonal antibodies against MERS-coronavirus spike protein,2020,Virus Research,278,,197863,,,,2,10.1016/j.virusres.2020.197863,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078277982&doi=10.1016%2fj.virusres.2020.197863&partnerID=40&md5=61f4ae7e01617de00924c9383cff81ca,"Science Unit, International Vaccine Institute, Seoul, South Korea; Department of Microbiology and Immunology, South Korea; Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea; Institute of Endemic Disease, Seoul National University Medical Research Center and Bundang Hospital, Seoul, South Korea; NKMAX Co., Ltd., Seongnam, South Korea; Department of Microbiology and Immunology, Brain Korea 21 PLUS Project for Medical Science, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, South Korea","Goo, J., Science Unit, International Vaccine Institute, Seoul, South Korea; Jeong, Y., Science Unit, International Vaccine Institute, Seoul, South Korea; Park, Y.-S., Science Unit, International Vaccine Institute, Seoul, South Korea; Yang, E., Science Unit, International Vaccine Institute, Seoul, South Korea; Jung, D.-I., Science Unit, International Vaccine Institute, Seoul, South Korea; Rho, S., Science Unit, International Vaccine Institute, Seoul, South Korea; Park, U., Department of Microbiology and Immunology, South Korea, Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea; Sung, H., NKMAX Co., Ltd., Seongnam, South Korea; Park, P.-G., Department of Microbiology and Immunology, Brain Korea 21 PLUS Project for Medical Science, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, South Korea; Choi, J.-A., Science Unit, International Vaccine Institute, Seoul, South Korea; Seo, S.H., Science Unit, International Vaccine Institute, Seoul, South Korea; Cho, N.H., Department of Microbiology and Immunology, South Korea, Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, South Korea, Institute of Endemic Disease, Seoul National University Medical Research Center and Bundang Hospital, Seoul, South Korea; Lee, H., NKMAX Co., Ltd., Seongnam, South Korea; Lee, J.M., Department of Microbiology and Immunology, Brain Korea 21 PLUS Project for Medical Science, Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, South Korea; Kim, J.-O., Science Unit, International Vaccine Institute, Seoul, South Korea; Song, M., Science Unit, International Vaccine Institute, Seoul, South Korea","Middle East Respiratory Syndrome coronavirus (MERS-CoV) causes severe pulmonary infection, with ∼35 % mortality. Spike glycoprotein (S) of MERS-CoV is a key target for vaccines and therapeutics because S mediates viral entry and membrane-fusion to host cells. Here, four different S subunit proteins, receptor-binding domain (RBD; 358–606 aa), S1 (1–751 aa), S2 (752–1296 aa), and SΔTM (1–1296 aa), were generated using the baculoviral system and immunized in mice to develop neutralizing antibodies. We developed 77 hybridomas and selected five neutralizing mAbs by immunization with SΔTM against MERS-CoV EMC/2012 strain S-pseudotyped lentivirus. However, all five monoclonal antibodies (mAb) did not neutralize the pseudotyped V534A mutation. Additionally, one mAb RBD-14F8 did not show neutralizing activity against pseudoviruses with amino acid substitution of L506 F or D509 G (England1 strain, EMC/2012 L506 F, and EMC/2012 D509 G), and RBD-43E4 mAb could not neutralize the pseudotyped I529 T mutation, while three other neutralizing mAbs showed broad neutralizing activity. This implies that the mutation in residue 506–509, 529, and 534 of S is critical to generate neutralization escape variants of MERS-CoV. Interestingly, all five neutralizing mAbs have binding affinity to RBD, although most mAbs generated by RBD did not have neutralizing activity. Additionally, chimeric antibodies of RBD-14F8 and RBD-43E4 with human Fc and light chain showed neutralizing effect against wild type MERS-CoV KOR/KNIH/002, similar to the original mouse mAbs. Thus, our mAbs can be utilized for the identification of specific mutations of MERS-CoV. © 2020 The Authors",Epitope; MERS-CoV; Monoclonal antibody; Neutralization; Neutralizing antibody; Pseudovirus,monoclonal antibody; monoclonal antibody rbd 23d3; monoclonal antibody rbd 25e4; monoclonal antibody rbd 40g7; monoclonal antibody rbd 43e4; monoclonal antibody s1 6e6; monoclonal antibody s2 14hb; unclassified drug; virus spike protein; virus vaccine; 786-O cell line; amino acid sequence; animal experiment; animal model; Article; binding affinity; codon; controlled study; drug purification; female; HEK293 cell line; human; human cell; hybridoma; Middle East respiratory syndrome; Middle East respiratory syndrome coronavirus; mouse; nonhuman; priority journal; protein subunit; receptor binding; Spodoptera frugiperda,"Chen, Y., Lu, S., Jia, H., Deng, Y., Zhou, J., Huang, B., Yu, Y., Tan, W., A novel neutralizing monoclonal antibody targeting the N-terminal domain of the MERS-CoV spike protein (2017) Emerg. 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Commun., 6, p. 7712; Wang, N., Shi, X., Jiang, L., Zhang, S., Wang, D., Tong, P., Guo, D., Wang, X., Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4 (2013) Cell Res., 23 (8), pp. 986-993; Wang, Q., Qi, J., Yuan, Y., Xuan, Y., Han, P., Wan, Y., Ji, W., Gao, G.F., Bat origins of MERS-CoV supported by bat coronavirus HKU4 usage of human receptor CD26 (2014) Cell Host Microbe, 16 (3), pp. 328-337; Yang, E., Cho, Y., Choi, J.A., Choi, Y., Park, P.G., Park, E., Lee, C.H., Song, M., Protection of mice against pandemic H1N1 influenza virus challenge after immunization with baculovirus-expressed stabilizing peptide fusion hemagglutinin protein (2015) J. Microbiol. Biotechnol., 25 (2), pp. 280-287; Yang, J.S., Park, S., Kim, Y.J., Kang, H.J., Kim, H., Han, Y.W., Lee, H.S., Kim, S.S., Middle east respiratory syndrome in 3 persons, South Korea, 2015 (2015) Emerg. Infect. Dis., 21 (11), pp. 2084-2087; Ying, T., Du, L., Ju, T.W., Prabakaran, P., Lau, C.C., Lu, L., Liu, Q., Dimitrov, D.S., Exceptionally potent neutralization of Middle East respiratory syndrome coronavirus by human monoclonal antibodies (2014) J. Virol., 88 (14), pp. 7796-7805; Yu, X., Zhang, S., Jiang, L., Cui, Y., Li, D., Wang, D., Wang, N., Wang, X., Structural basis for the neutralization of MERS-CoV by a human monoclonal antibody MERS-27 (2015) Sci. Rep., 5, p. 13133; Zhang, S., Zhou, P., Wang, P., Li, Y., Jiang, L., Jia, W., Wang, H., Zhang, L., Structural definition of a unique neutralization epitope on the receptor-binding domain of MERS-CoV spike glycoprotein (2018) Cell Rep., 24 (2), pp. 441-452","Kim, J.-O.; Science Unit, International Vaccine InstituteSouth Korea; email: jokim@ivi.int",,Elsevier B.V.,1681702,,VIRED,31945421,English,Virus Res.,Article,Final,Open Access,Scopus,2-s2.0-85078277982,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Fan C., Liu L., Guo W., Yang A., Ye C., Jilili M., Ren M., Xu P., Long H., Wang Y.",57215492149;57215495595;57208136614;57215506817;57215507527;57215501178;57215503799;57215507556;57008685600;57215508338;,Prediction of epidemic spread of the 2019 novel coronavirus driven by spring festival transportation in China: A population‐based study,2020,International Journal of Environmental Research and Public Health,17,5,1679,,,,,10.3390/ijerph17051679,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081035695&doi=10.3390%2fijerph17051679&partnerID=40&md5=5c7a30fed2905da1b2e625147ec27fc7,"School of Sociology, Central China Normal University, Wuhan, Hubei Province 430079, China; School of Public Administration, Hangzhou Normal University, Hangzhou, Zhejiang Province 311121, China; School of Social and Behavioral Sciences, Nanjing University, Nanjing, Jiangsu Province 210046, China; School of Sociology, Wuhan University, Wuhan, Hubei Province 430072, China; School of Economics, Minzu University of China, Beijing, 100081, China","Fan, C., School of Sociology, Central China Normal University, Wuhan, Hubei Province 430079, China; Liu, L., School of Public Administration, Hangzhou Normal University, Hangzhou, Zhejiang Province 311121, China, School of Social and Behavioral Sciences, Nanjing University, Nanjing, Jiangsu Province 210046, China; Guo, W., School of Social and Behavioral Sciences, Nanjing University, Nanjing, Jiangsu Province 210046, China; Yang, A., School of Social and Behavioral Sciences, Nanjing University, Nanjing, Jiangsu Province 210046, China; Ye, C., School of Social and Behavioral Sciences, Nanjing University, Nanjing, Jiangsu Province 210046, China; Jilili, M., School of Social and Behavioral Sciences, Nanjing University, Nanjing, Jiangsu Province 210046, China; Ren, M., School of Social and Behavioral Sciences, Nanjing University, Nanjing, Jiangsu Province 210046, China; Xu, P., School of Sociology, Wuhan University, Wuhan, Hubei Province 430072, China; Long, H., School of Economics, Minzu University of China, Beijing, 100081, China; Wang, Y., School of Sociology, Central China Normal University, Wuhan, Hubei Province 430079, China","After the 2019 novel coronavirus (2019‐nCoV) outbreak, we estimated the distribution and scale of more than 5 million migrants residing in Wuhan after they returned to their hometown communities in Hubei Province or other provinces at the end of 2019 by using the data from the 2013–2018 China Migrants Dynamic Survey (CMDS). We found that the distribution of Wuhan’s migrants is centred in Hubei Province (approximately 75%) at a provincial level, gradually decreasing in the surrounding provinces in layers, with obvious spatial characteristics of circle layers and echelons. The scale of Wuhan’s migrants, whose origins in Hubei Province give rise to a gradient reduction from east to west within the province, and account for 66% of Wuhan’s total migrants, are from the surrounding prefectural‐level cities of Wuhan. The distribution comprises 94 districts and counties in Hubei Province, and the cumulative percentage of the top 30 districts and counties exceeds 80%. Wuhan’s migrants have a large proportion of middle‐aged and high‐risk individuals. Their social characteristics include nuclear family migration (84%), migration with families of 3–4 members (71%), a rural household registration (85%), and working or doing business (84%) as the main reason for migration. Using a quasi‐experimental analysis framework, we found that the size of Wuhan’s migrants was highly correlated with the daily number of confirmed cases. Furthermore, we compared the epidemic situation in different regions and found that the number of confirmed cases in some provinces and cities in Hubei Province may be underestimated, while the epidemic situation in some regions has increased rapidly. The results are conducive to monitoring the epidemic prevention and control in various regions. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.",2019 novel coronavirus; Population size; Quasi‐experimental approach; Social characteristics of floating population; The origins of Wuhanʹs migrants,"disease spread; epidemic; experimental study; festival; immigrant; population size; prediction; severe acute respiratory syndrome; viral disease; Article; China; commercial phenomena; conceptual framework; controlled study; coronavirus disease 2019; Coronavirus infection; epidemic; geographic distribution; health survey; high risk population; household; human; infection control; infection prevention; infection risk; major clinical study; migrant; migration; nuclear family; population research; prediction; quasi experimental study; registration; rural area; social aspect; spring; adult; aged; Betacoronavirus; city; Coronavirinae; Coronavirus infection; epidemic; family health; family size; female; forecasting; history; isolation and purification; leisure; male; middle aged; pathogenicity; rural population; season; virus pneumonia; young adult; China; Hubei; Hubei; Wuhan; Coronavirus; COVID-19; severe acute respiratory syndrome coronavirus 2; Adult; Aged; Anniversaries and Special Events; Betacoronavirus; China; Cities; Coronavirus; Coronavirus Infections; Emigration and Immigration; Epidemics; Family Characteristics; Family Health; Female; Forecasting; Holidays; Humans; Male; Middle Aged; Pneumonia, Viral; Rural Population; Seasons; Young Adult","Heymann, D.L., Data sharing and outbreaks: Best practice exemplified (2020) Lancet, 395, pp. 469-470; Mahase, E., China coronavirus: What do we know so far? (2020) BMJ; Wu, J.T., Leung, K., Leung, G.M., Nowcasting and forecasting the potential domestic and international spread of the 2019‐nCoV outbreak originating in Wuhan, China: A modelling study (2020) Lancet, 395, pp. 689-697; The Current Epidemic of Pneumonia in Our City by Wuhan Municipal Health Commission, , http://wjw.wh.gov.cn/front/web/showDetail/2019123108989, accessed on 25 January 2020; Novel Coronavirus (2019‐nCoV) Situation report‐6, , https://www.who.int/docs/default‐source/coronaviruse/situation‐reports/20200126‐sitrep‐6‐2019‐‐ncov.pdf?sfvrsn=beaeee0c_4, Geneva: World Health Organization., Available online, accessed on 27 January 2020; Ding, X.Y., National Real‐time Epidemic Website, , https://ncov.dxy.cn/ncovh5/view/pneumonia?scene=2&clicktime=1579593095&enterid=1579593095&from=groupmessage&isappinstalled=0, Available online, accessed from 25 January to 31 January 2020; Novel Coronavirus (2019‐nCoV) Situation report‐10, , https://www.who.int/docs/default‐source/coronaviruse/situation‐reports/20200130‐sitrep‐10‐ncov.pdf?sfvrsn=d0b2e480_2, Geneva: World Health Organization, accessed on 31 January 2020; Read, J.M., Jessica, R.E., Bridgen, J.R.E., Cummings, D.A.T., Ho, A., Jewell, C.P., Novel coronavirus 2019‐ nCoV: Early estimation of epidemiological parameters and epidemic predictions Medrxiv, 2020; Imai, N., Cori, A., Dorigatti, I., Baguelin, M., Donnelly, C.A., Riley, S., Ferguson, N.M., Report 3: Transmissibility of 2019‐nCoV, , https://www.imperial.ac.uk/media/imperial-college/medicine/sph/ide/gida‐fellowships/Imperial‐2019‐nCoV‐transmissibility.pdf, Available online, accessed on 26 January 2020; Chen, N., Zhou, M., Dong, X., Qu, J., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study (2020) Lancet, 395, pp. 507-513; Zhu, N., Zhang, D.Y., Wang, W.L., Li, X.W., Yang, B., Song, J.D., Zhao, X., Lu, R.J., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N. Engl. J. Med., 382, pp. 727-733; Chan, J.F.W., Yuan, S., Kok, K.H., To, K.K.W., Chu, H., Yang, J., Xing, F.F., Poon, R.W.S., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to‐person transmission: A study of a family cluster (2020) Lancet, 395, pp. 514-523; Wang, C., Horby, P.W., Hayden, F.G., Gao, G.F., A novel coronavirus outbreak of global health concern (2020) Lancet, 395, pp. 470-473; Emerging understandings of 2019‐nCoV (2020) Lancet, 395, p. 311; Paules, C.I., Marston, H.D., Fauci, A.S., Coronavirus infections‐more than just the common cold (2020) JAMA, 323, pp. 707-708; Chen, Z.L., Zhang, W.J., Lu, Y., Guo, C., Guo, Z.M., Liao, C.H., Zhang, X., Li, Q.L., From SARS‐CoV to Wuhan 2019‐nCoV Outbreak: Similarity of Early Epidemic and Prediction of Future Trends (2020) Biorxiv; Munster, V.J., Koopmans, M., Koopmans, M., Doremalen, N.V., Riel, D.V., Wit, E.D., A novel coronavirus emerging in China—key questions for impact assessment (2020) The New England Journal of Medicine, 382, pp. 692-694; Perlman, S., Another decade, another coronavirus (2020) N. Engl. J. Med., 382, pp. 760-762; Imai, N., Dorigatti, I., Cori, A., Riley, S., Ferguson, N.F., Report 1: Estimating the Potential Total Number of Novel Coronavirus Cases in Wuhan City, China, , https://www.imperial.ac.uk/media/imperial‐college/medicine/sph/ide/gida‐fellowships/2019‐nCoV-outbreak‐report‐17‐01‐2020.pdf, Available online:, accessed on 23 January 2020; Imai, N., Dorigatti, I., Cori, A., Riley, S., Ferguson, N.F., Report 2: Estimating the Potential Total Number of Novel Coronavirus Cases in Wuhan City, China, , https://www.imperial.ac.uk/media/imperial‐college/medicine/sph/ide/gida‐fellowships/2019‐nCoV-outbreak‐report‐22‐01‐2020.pdf, Available online:, accessed on 24 January 2020; Shen, M., Peng, Z., Yanni, X.Y., Zhang, L., Modelling the epidemic trend of the 2019 novel coronavirus outbreak in China (2020) Biorxiv; Huang, C.L., Wang, Y.M., Li, X.W., Ren, L.L., Zhao, J.P., Hu, Y., Zhang, L., Gu, X.Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506; Health Commission of Guangdong Province. Epidemic Situation of the Novel Coronavirus in Guangdong Province Published on Jan 23 2020, , http://wsjkw.gd.gov.cn/zwyw_yqxx/content/post_2878571.html, Available online:, accessed on 25 January 2020; 15 Chinese Medical Workers Confirmed Infected with Coronavirus, , http://www.xinhuanet.com/english/2020‐01/21/c_138721955.htm; Wuhan Statistical Communiqué on National Economic and Social Development, , http://www.tjcn.org/tjgb/17hb/35881_3.html, accessed on 22 January 2020; The Chinese New Year Travel Rush—The World’s Largest Annual Human Migration, , https://www.chinahighlights.com/travelguide/special‐report/chinese‐new-year/transportation.htm, Available online, accessed on 24 January 2020; Wuhan Implements Restriction to Curb the Spread of the Epidemic, , http://www.hubei.gov.cn/zhuanti/2020/gzxxgzbd/zxtb/202001/t20200121_2013644.shtml, Available online, accessed on 23 January 2020; Real‐time Update on Coronavirus Outbreak, , http://www.globaltimes.cn/content/1177737.shtml, Available online:, accessed on 29 January 2020; Hu, X., Cook, S., Salazara, M.A., Internal Migration and Health in China (2008) Lancet, 372, pp. 1717-1719; China Grapples with Mystery pneumonia‐like Illness, , https://www.nytimes.com/2020/01/06/world/asia/china‐SARS‐pneumonialike.html, Available online:, accessed on 6 January 2020; Therese, H., Ye, X., Li, L., Wang, H., Health Status and Access to Health Care of Migrant Workers in China (2008) Public Health Rep, 123, pp. 189-197","Liu, L.; School of Public Administration, Hangzhou Normal UniversityChina; email: llp@nju.edu.cn",,MDPI AG,16617827,,,32143519,English,Int. J. Environ. Res. Public Health,Article,Final,Open Access,Scopus,2-s2.0-85081035695,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wang C., Pan R., Wan X., Tan Y., Xu L., Ho C.S., Ho R.C.",57215593271;57215574869;57215578533;57215589896;57215581334;56076309400;23004658600;,Immediate psychological responses and associated factors during the initial stage of the 2019 coronavirus disease (COVID-19) epidemic among the general population in China,2020,International Journal of Environmental Research and Public Health,17,5,1729,,,,,10.3390/ijerph17051729,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081198190&doi=10.3390%2fijerph17051729&partnerID=40&md5=26155a6452c89a9bbb2fbbd054e35aeb,"Institute of Cognitive Neuroscience, Faculty of Education, Huaibei Normal University, Huaibei, 235000, China; Department of Psychological Medicine, National University Health System, Kent Ridge119228, Singapore; Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Kent Ridge119228, Singapore; Institute of Health Innovation and Technology (iHealthtech), National University of Singapore, Kent Ridge119077, Singapore","Wang, C., Institute of Cognitive Neuroscience, Faculty of Education, Huaibei Normal University, Huaibei, 235000, China; Pan, R., Institute of Cognitive Neuroscience, Faculty of Education, Huaibei Normal University, Huaibei, 235000, China; Wan, X., Institute of Cognitive Neuroscience, Faculty of Education, Huaibei Normal University, Huaibei, 235000, China; Tan, Y., Institute of Cognitive Neuroscience, Faculty of Education, Huaibei Normal University, Huaibei, 235000, China; Xu, L., Institute of Cognitive Neuroscience, Faculty of Education, Huaibei Normal University, Huaibei, 235000, China; Ho, C.S., Department of Psychological Medicine, National University Health System, Kent Ridge119228, Singapore, Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Kent Ridge119228, Singapore; Ho, R.C., Institute of Cognitive Neuroscience, Faculty of Education, Huaibei Normal University, Huaibei, 235000, China, Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Kent Ridge119228, Singapore, Institute of Health Innovation and Technology (iHealthtech), National University of Singapore, Kent Ridge119077, Singapore","Background: The 2019 coronavirus disease (COVID-19) epidemic is a public health emergency of international concern and poses a challenge to psychological resilience. Research data are needed to develop evidence-driven strategies to reduce adverse psychological impacts and psychiatric symptoms during the epidemic. The aim of this study was to survey the general public in China to better understand their levels of psychological impact, anxiety, depression, and stress during the initial stage of the COVID-19 outbreak. The data will be used for future reference. Methods: From 31 January to 2 February 2020, we conducted an online survey using snowball sampling techniques. The online survey collected information on demographic data, physical symptoms in the past 14 days, contact history with COVID-19, knowledge and concerns about COVID-19, precautionary measures against COVID-19, and additional information required with respect to COVID-19. Psychological impact was assessed by the Impact of Event Scale-Revised (IES-R), and mental health status was assessed by the Depression, Anxiety and Stress Scale (DASS-21). Results: This study included 1210 respondents from 194 cities in China. In total, 53.8% of respondents rated the psychological impact of the outbreak as moderate or severe; 16.5% reported moderate to severe depressive symptoms; 28.8% reported moderate to severe anxiety symptoms; and 8.1% reported moderate to severe stress levels. Most respondents spent 20–24 h per day at home (84.7%); were worried about their family members contracting COVID-19 (75.2%); and were satisfied with the amount of health information available (75.1%). Female gender, student status, specific physical symptoms (e.g., myalgia, dizziness, coryza), and poor self-rated health status were significantly associated with a greater psychological impact of the outbreak and higher levels of stress, anxiety, and depression (p < 0.05). Specific up-to-date and accurate health information (e.g., treatment, local outbreak situation) and particular precautionary measures (e.g., hand hygiene, wearing a mask) were associated with a lower psychological impact of the outbreak and lower levels of stress, anxiety, and depression (p < 0.05). Conclusions: During the initial phase of the COVID-19 outbreak in China, more than half of the respondents rated the psychological impact as moderate-to-severe, and about one-third reported moderate-to-severe anxiety. Our findings identify factors associated with a lower level of psychological impact and better mental health status that can be used to formulate psychological interventions to improve the mental health of vulnerable groups during the COVID-19 epidemic. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.",Anxiety; Coronavirus; Depression; Epidemic; Knowledge; Precaution; Psychological impact; Respiratory symptoms; Stress,"disease spread; epidemic; health status; knowledge; mental health; psychology; public health; severe acute respiratory syndrome; symptom; anxiety; Article; attitude to health; China; common cold; coronavirus disease 2019; Coronavirus infection; demography; depression; Depression Anxiety Stress Scale; disease association; disease severity; dizziness; epidemic; gender; hand washing; health status; health survey; human; Impact of Events Scale; medical history; medical information; mental stress; myalgia; online system; snowball sample; symptomatology; universal precaution; virus transmission; adolescent; adult; aged; anxiety disorder; child; complication; Coronavirinae; Coronavirus infection; cross-sectional study; depression; female; male; mental health; middle aged; psychological resilience; psychology; questionnaire; virus pneumonia; young adult; China; Coronavirus; COVID-19; Adolescent; Adult; Aged; Anxiety; Anxiety Disorders; Child; China; Coronavirus; Coronavirus Infections; Cross-Sectional Studies; Depression; Disease Outbreaks; Epidemics; Female; Health Status; Humans; Male; Mental Health; Middle Aged; Pneumonia, Viral; Resilience, Psychological; Surveys and Questionnaires; Young Adult","Wang, C., A novel coronavirus outbreak of global health concern (2020) Lancet, 395, pp. 470-473; Hawryluck, L., SARS control and psychological effects of quarantine, Toronto, Canada (2004) Emerg. Infect. Dis., 10, pp. 1206-1212; Nishiura, H., The Extent of Transmission of Novel Coronavirus in Wuhan, China, 2020 (2020) J. Clin. Med., 9, p. 330; Mahase, E., China coronavirus: WHO declares international emergency as death toll exceeds 200 (2020) BMJ Clin. Res. Ed., 368; Paules, C.I., Marston, H.D., Fauci, A.S., Coronavirus Infections-More Than Just the Common Cold (2020) JAMA; Huang, C., Clinical features of patients infected with 2019 novel coronavirus in Wuhan (2020) China. Lancet, 395, pp. 497-506; Cao, Z., (2020) Estimating the Effective Reproduction Number of the 2019-Ncov in China; Zhao, S., Estimating the Unreported Number of Novel Coronavirus (2019-nCoV) Cases in China in the First Half of January 2020: A Data-Driven Modelling Analysis of the Early Outbreak (2020) J. Clin. Med., 9, p. 388; Li, Q., Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia (2020) N. Engl. J. Med.; Rothe, C., Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany (2020) N. Engl. J. Med.; Ryu, S., Chun, B.C., Korean Society of Epidemiology-nCo, an interim review of the epidemiological characteristics of 2019 novel coronavirus (2020) Epidemiol. Health, 42; Chen, N., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study (2020) Lancet, 395, pp. 507-513; Holshue, M.L., First Case of 2019 Novel Coronavirus in the United States (2020) N. Engl. J. Med., , [CrossRef] [PubMed]; Nishiura, H., The Rate of Underascertainment of Novel Coronavirus (2019-nCoV) Infection: Estimation Using Japanese Passengers Data on Evacuation Flights (2020) J. Clin. Med., 9, p. 419; Horton, R., Offline: 2019-nCoV—“A desperate plea” (2020) Lancet, 395, p. 400; Xiang, Y.-T., Timely mental health care for the 2019 novel coronavirus outbreak is urgently needed (2020) Lancet Psychiatry, 7, pp. 228-229; Hall, R.C.W., Chapman, M.J., The 1995 Kikwit Ebola outbreak: Lessons hospitals and physicians can apply to future viral epidemics (2008) Gen. Hosp. Psychiatry, 30, pp. 446-452; Rubin, G.J., Potts, H.W.W., Michie, S., The impact of communications about swine flu (Influenza A H1N1v) on public responses to the outbreak: Results from 36 national telephone surveys in the UK (2010) Health Technol. Assess., 14, pp. 183-266; van Bortel, T., Psychosocial effects of an Ebola outbreak at individual, community and international levels (2016) Bull. World Health Organ., 94, pp. 210-214; Sim, K., Psychosocial and coping responses within the community health care setting towards a national outbreak of an infectious disease (2010) J. Psychosom. Res., 68, pp. 195-202; Leung, G.M., The impact of community psychological responses on outbreak control for severe acute respiratory syndrome in Hong Kong (2003) J. Epidemiol. Community Health, 57, pp. 857-863; Lu, R., Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding (2020) Lancet, , CrossRef; Rubin, G.J., Wessely, S., The psychological effects of quarantining a city (2020) BMJ Clin. Res. Ed., 368; Leung, G.M., Community psycho-behavioural surveillance and related impact on outbreak control in Hong Kong and Singapore during the SARS epidemic (2009) Hong Kong Med. J., 15, pp. 30-34; Zhang, M.W., Usage of social media and smartphone application in assessment of physical and psychological well-being of individuals in times of a major air pollution crisis (2014) JMIR Mhealth Uhealth, 2, p. 16; Zhang, M.W.B., Methodology of developing a smartphone application for crisis research and its clinical application (2014) Technol. Health Care Off. J. Eur. Soc. Eng. Med., 22, pp. 547-559; Creamer, M., Bell, R., Failla, S., Psychometric properties of the Impact of Event Scale-Revised (2003) Behav. Res. Ther., 41, pp. 1489-1496; Le, T.A., Multi-level predictors of psychological problems among methadone maintenance treatment patients in difference types of settings in Vietnam (2019) Subst. Abus. Treat. Prev. Policy, 14, p. 39; Ho, C.S.H., Relationship of Anxiety and Depression with Respiratory Symptoms: Comparison between Depressed and Non-Depressed Smokers in Singapore (2019) Int. J. Environ. Res. Public Health, 16, p. 163; Quek, T.C., Misophonia in Singaporean Psychiatric Patients: A Cross-Sectional Study (2018) Int. J. Environ. Res. Public Health, 15, p. 1410; McAlonan, G.M., Immediate and sustained psychological impact of an emerging infectious disease outbreak on health care workers (2007) Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie, 52, pp. 241-247; Patel, A., Jernigan, D.B., Initial Public Health Response and Interim Clinical Guidance for the 2019 Novel Coronavirus Outbreak—United States, 31 December 2019–4 February 2020 (2020) MMWR Morb. Mortal. Wkly. Rep., 69, pp. 140-146; Lim, G.Y., Prevalence of Depression in the Community from 30 Countries between 1994 and 2014 (2018) Sci. Rep., 8, p. 2861; Zhang, M.W.B., Ho, C.S.H., Ho, R.C.M., Methodology of development and students’ perceptions of a psychiatry educational smartphone application (2014) Technol. Health Care Off. J. Eur. Soc. Eng. Med., 22, pp. 847-855; Do, T.T.T., Receptiveness and preferences of health-related smartphone applications among Vietnamese youth and young adults (2018) BMC Public Health, 18; Geddie, J.S.J., (2020) To Mask Or Not to Mask: Confusion Spreads over Coronavirus Protection, , https://uk.reuters.com/article/us-china-health-masks-safety/to-mask-or-not-to-mask-confusion-spreads-over-coronavirus-protection-idUKKBN1ZU0PH, 31 January, (accessed on 8 February 2020); (2020) Advice for the Public: When and How to Use Masks, , https://www.who.int/emergencies/diseases/novel-coronavirus-2019/advice-for-public/when-and-how-to-use-masks, 2019-nCoV), Available online, accessed on 8 February 2020; Ho, R.C., Impact of 2013 south Asian haze crisis: Study of physical and psychological symptoms and perceived dangerousness of pollution level (2014) BMC Psychiatry, 14","Ho, R.C.; Institute of Cognitive Neuroscience, Faculty of Education, Huaibei Normal UniversityChina; email: pcmrhcm@nus.edu.sg",,MDPI AG,16617827,,,32155789,English,Int. J. Environ. Res. Public Health,Article,Final,Open Access,Scopus,2-s2.0-85081198190,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Barry M., Al Amri M., Memish Z.A.",55881962500;57215812475;7005059350;,COVID-19 in the Shadows of MERS-CoV in the Kingdom of Saudi Arabia,2020,Journal of epidemiology and global health,10,1,,1,3,,,10.2991/jegh.k.200218.003,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081971948&doi=10.2991%2fjegh.k.200218.003&partnerID=40&md5=21af4727b1a61c104c6c5f05113e1fc5,"Division of Infectious Disease, College of Medicine, King Saud University, Kingdom of Saudi Arabia, Riyadh, Saudi Arabia; Department of Infectious Disease, King Faisal Specialist Hospital and Research Center, Kingdom of Saudi Arabia, Riyadh, Saudi Arabia; Director Research and Innovation Centre, King Saud Medical City, Ministry of Health, Kingdom of Saudi Arabia, Riyadh, Saudi Arabia; College of Medicine, Alfaisal University, Kingdom of Saudi Arabia, Riyadh, Saudi Arabia; Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, United States","Barry, M., Division of Infectious Disease, College of Medicine, King Saud University, Kingdom of Saudi Arabia, Riyadh, Saudi Arabia; Al Amri, M., Department of Infectious Disease, King Faisal Specialist Hospital and Research Center, Kingdom of Saudi Arabia, Riyadh, Saudi Arabia; Memish, Z.A., Director Research and Innovation Centre, King Saud Medical City, Ministry of Health, Kingdom of Saudi Arabia, Riyadh, Saudi Arabia, College of Medicine, Alfaisal University, Kingdom of Saudi Arabia, Riyadh, Saudi Arabia, Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, United States","Middle East Respiratory Syndrome Coronavirus (MERS-CoV) has plagued the Middle East since it was first reported in 2012. Recently, at the end of December 2019, a cluster of pneumonia cases were reported from Wuhan city, Hubei Province, China, linked to a wet seafood market with a new coronavirus identified as the etiologic agent currently named SARS-CoV-2. Most cases are in Mainland China with international spread to 25 countries. The novelty of the virus, the rapid national and international spread, and the lack of therapeutic and preventative strategies have led the WHO International Health Regulation emergency committee to declare the disease as Public Health Emergency of International Concern (PHEIC) on January 30, 2020. As it relates to countries with the ongoing MERS-CoV community cases and hospital acquired infections, there will be a huge challenge for HCWs to deal with both coronaviruses, especially with the lack of standardized and approved point of care testing. This challenge will now be faced by the whole global health community dealing with COVID-19 since both coronaviruses have similar presentation. Those patients should now be tested for both MERS-CoV and SARS-CoV-2 simultaneously, and with the continuing wide international spread of SARS-CoV-2, the travel history to China in the last 14 days will be of less significance. © 2020 The Authors. Published by Atlantis Press International B.V.",COVID-19; MERS-CoV; SARS-CoV-2; Saudi Arabia,"COVID-19; China; civil defense; Coronavirus infection; cross infection; epidemic; global health; human; Middle East respiratory syndrome coronavirus; Saudi Arabia; severe acute respiratory syndrome; travel; virus pneumonia; China; Civil Defense; Coronavirus Infections; Cross Infection; Disease Outbreaks; Global Health; Humans; Middle East Respiratory Syndrome Coronavirus; Pneumonia, Viral; Saudi Arabia; Severe Acute Respiratory Syndrome; Travel",,,,NLM (Medline),22106014,,,32175703,English,J Epidemiol Glob Health,Article,Final,Open Access,Scopus,2-s2.0-85081971948,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Sarzi-Puttini P., Giorgi V., Sirotti S., Marotto D., Ardizzone S., Rizzardini G., Antinori S., Galli M.",35477093200;57215382699;57194903181;57211741626;7005068246;7003758798;7005365275;57203947887;,"COVID-19, cytokines and immunosuppression: what can we learn from severe acute respiratory syndrome?",2020,Clinical and experimental rheumatology,38,2,,337,342,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082542383&partnerID=40&md5=902f2d1b3731d528439e97373b8b2249,"Rheumatology Unit, ASST-Fatebenefratelli L. Sacco University Hospital, University of Milan, Italy; Rheumatology Unit, P. Dettori Hospital, Tempio Pausania, Italy; Gastrointestinal Unit, ASST-Fatebenefratelli Sacco. L. Sacco Department of Biochemical and Clinical Sciences, University of Milan, Italy; Department of Infectious Diseases, Division of Infectious Diseases ASST Fatebenefratelli-Sacco, Milan, Italy; Department of Biomedical and Clinical Sciences 'Luigi Sacco', University of Milan, III Division of Infectious Diseases, ASST Fatebenefratelli Sacco, Luigi Sacco Hospital, Milan, Italy","Sarzi-Puttini, P., Rheumatology Unit, ASST-Fatebenefratelli L. Sacco University Hospital, University of Milan, Italy; Giorgi, V., Rheumatology Unit, ASST-Fatebenefratelli L. Sacco University Hospital, University of Milan, Italy; Sirotti, S., Rheumatology Unit, ASST-Fatebenefratelli L. Sacco University Hospital, University of Milan, Italy; Marotto, D., Rheumatology Unit, P. Dettori Hospital, Tempio Pausania, Italy; Ardizzone, S., Gastrointestinal Unit, ASST-Fatebenefratelli Sacco. L. Sacco Department of Biochemical and Clinical Sciences, University of Milan, Italy; Rizzardini, G., Department of Infectious Diseases, Division of Infectious Diseases ASST Fatebenefratelli-Sacco, Milan, Italy; Antinori, S., Department of Biomedical and Clinical Sciences 'Luigi Sacco', University of Milan, III Division of Infectious Diseases, ASST Fatebenefratelli Sacco, Luigi Sacco Hospital, Milan, Italy; Galli, M., Department of Biomedical and Clinical Sciences 'Luigi Sacco', University of Milan, III Division of Infectious Diseases, ASST Fatebenefratelli Sacco, Luigi Sacco Hospital, Milan, Italy","A severe outbreak of coronavirus disease 2019 (COVID-19) emerged in China in December 2019, and spread so rapidly that more than 200,000 cases have so far been reported worldwide; on January 30, 2020, the WHO declared it the sixth public health emergency of international concern. The two previously reported coronavirus epidemics (severe acute respiratory syndrome [SARS] and Middle East respiratory syndrome [MERS]) share similar pathogenetic, epidemiological and clinical features as COVID-19. As little is currently known about SARS-CoV-2, it is likely that lessons learned from these major epidemics can be applied to the new pandemic, including the use of novel immunosuppressive drugs.",,,,,,NLM (Medline),0392856X,,,32202240,English,Clin. Exp. Rheumatol.,Review,Final,,Scopus,2-s2.0-85082542383,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Cupertino M., Resende M., Mayer N., Carvalho L., Siqueira-Batista R.",55918091300;57216057685;57215555511;57215727120;7004326329;,Emerging and re-emerging human infectious diseases: A systematic review of the role of wild animals with a focus on public health impact,2020,Asian Pacific Journal of Tropical Medicine,13,3,,99,106,,,10.4103/1995-7645.277535,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081150234&doi=10.4103%2f1995-7645.277535&partnerID=40&md5=d3acf8efbf4b5ccc4121dbf2ce94a235,"Medical School, Faculdade Dinâmica Do Vale Do Piranga, Ponte Nova. Minas Gerais, Brazil; Laboratory of Epidemiological and Computational Methods in Health, Department of Medicine and Nursing, Universidade Federal de Viçosa, Minas Gerais, Brazil; Department of Veterinary Medicine, Universidade Federal de Viçosa, Viçosa. Minas Gerais, Brazil","Cupertino, M., Medical School, Faculdade Dinâmica Do Vale Do Piranga, Ponte Nova. Minas Gerais, Brazil, Laboratory of Epidemiological and Computational Methods in Health, Department of Medicine and Nursing, Universidade Federal de Viçosa, Minas Gerais, Brazil, Department of Veterinary Medicine, Universidade Federal de Viçosa, Viçosa. Minas Gerais, Brazil; Resende, M., Laboratory of Epidemiological and Computational Methods in Health, Department of Medicine and Nursing, Universidade Federal de Viçosa, Minas Gerais, Brazil; Mayer, N., Department of Veterinary Medicine, Universidade Federal de Viçosa, Viçosa. Minas Gerais, Brazil; Carvalho, L., Medical School, Faculdade Dinâmica Do Vale Do Piranga, Ponte Nova. Minas Gerais, Brazil, Department of Veterinary Medicine, Universidade Federal de Viçosa, Viçosa. Minas Gerais, Brazil; Siqueira-Batista, R., Medical School, Faculdade Dinâmica Do Vale Do Piranga, Ponte Nova. Minas Gerais, Brazil, Laboratory of Epidemiological and Computational Methods in Health, Department of Medicine and Nursing, Universidade Federal de Viçosa, Minas Gerais, Brazil","Infectious diseases continue to impose unpredictable burdens on global health and economies, a subject that requires constant research and updates. In this sense, the objective of the present article was to review studies on the role of wild animals as reservoirs and/or dispersers of etiological agents of human infectious diseases in order to compile data on the main wild animals and etiological agents involved in zoonotic outbreaks. A systematic review was carried out using PRISMA guidelines, using the PubMed, Scopus and SciELO platforms as data banks. The descriptors used were 'zoonosis', 'human infectious diseases' and 'wild animals'. The results show that wild animals (mainly bats, birds and primates) play an important role in the dissemination of etiological agents (mainly viruses, as a new coronavirus called 2019 Novel Coronavirus) in extensive geographic regions. Moreover, these wild animal organisms can act as the site for essential biotic synergy among several pathogenic microorganisms, promoting a higher rate of adaptation, mutation and even genetic recombination, with consequent stimulation of new strains and subtypes, inducing new infectious agents with unknown virulent potential. In conclusion, the monitoring of these diseases and adequate preparation for possible epidemics and pandemics are fundamental conditions for the mitigation of their future impact. The zoonotic threat of these etiological agents and the impact on public health can be enormous as shown by the ongoing epidemic of 2019 novel coronavirus (2019- nCoV) infections. © 2020 Asian Pacific Journal of Tropical Medicine Produced by Wolters KluwerMedknow. All rights reserved.",2019-nCoV; Epidemics; Epidemiology; Virology; Zoonosis,2019 novel coronavirus; bat; bird; Coronavirinae; epidemic; genetic recombination; human; infection; nonhuman; Preferred Reporting Items for Systematic Reviews and Meta-Analyses; primate; priority journal; Review; systematic review; virus strain; wild animal; zoonosis,"Fauci, A.S., Emerging and reemerging infectious diseases: The perpetual challenge (2005) Acad Med, 80 (12), pp. 1079-1085; Spahr, C., Knauf-Witzens, T., Vahlenkamp, T., Ulrich, R.G., Johne, R., Hepatitis e virus and related viruses in wild, domestic and zoo animals: A review (2018) Zoonoses Public Health, 65 (1), pp. 11-29; Cunningham, A.A., Daszak, P., Wood, J.L.N., One health, emerging infectious diseases and wildlife: Two decades of progress? (2018) Philos Trans R Soc Lond B Biol Sci, 372 (1725), p. 20160167; Sookaromdee, P., Wiwanitkit, V., Imported cases of 2019-novel coronavirus (2019-nCoV) infections in Thailand: Mathematical modelling of the outbreak (2020) Asian Pac J Trop Med, 13 (3); Ck, J., Hitchens, P.L., Evans, T.S., Goldstein, T., Thomas, K., Clements, A., Spillover and pandemic properties of zoonotic viruses with high host plasticity (2015) Nature, 5, pp. 1-8. , 14830; The Lancet. 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(2018) Evol Ecol Res, 19 (3), pp. 215-226; Shiravand, B., Hanafi-Bojd, A.A., Tafti, A.A.D., Abai, M.R., Almodarresi, A., Mirzaei, M., Climate change and potential distribution of zoonotic cutaneous leishmaniasis in Central Iran: Horizon 2030 and 2050 (2019) Asian Pac J Trop Med, 12 (5), pp. 204-215; Zhu, Z., Chan, J.F., Tee, K.M., Choi, G.K., Lau, S.K., Woo, P.C., Comparative genomic analysis of pre-epidemic and epidemic Zika virus strains for virological factors potentially associated with the rapidly expanding epidemic (2016) Emerg Microbes Infect, 5, p. e22","Cupertino, M.; Medical School, Faculdade Dinâmica Do Vale Do PirangaBrazil; email: marli.cupertino@ufv.br",,Wolters Kluwer Medknow Publications,19957645,,,,English,Asian Pac. J. Trop. Med.,Review,Final,,Scopus,2-s2.0-85081150234,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Delogu M., Cotti C., Lelli D., Sozzi E., Trogu T., Lavazza A., Garuti G., Castrucci M.R., Vaccari G., De Marco M.A., Moreno A.",6701330023;6504086635;26436391000;26436314700;56290998300;35339480400;57215547778;7007001125;7004557999;7004975474;56452258900;,Eco-virological preliminary study of potentially emerging pathogens in hedgehogs (Erinaceus europaeus) recovered at a wildlife treatment and rehabilitation center in Northern Italy,2020,Animals,10,3,407,,,,,10.3390/ani10030407,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081139965&doi=10.3390%2fani10030407&partnerID=40&md5=f52c678931121056f996a3eb05c80681,"Department of Veterinary Medical Sciences, University of Bologna, 50 Via Tolara di Sopra, Ozzano dell’Emilia, BO 40064, Italy; Virology Unit, Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna, 7/9 Via Bianchi, Brescia, 25124, Italy; Department of Infectious Diseases, Istituto Superiore di Sanità, 299 Viale Regina Elena, Rome, 00161, Italy; Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, 299 Viale Regina Elena, Rome, 00161, Italy; Wildlife Service, Institute for Environmental Protection and Research (ISPRA), 9 Via Ca’ Fornacetta, Ozzano dell’Emilia, BO 40064, Italy","Delogu, M., Department of Veterinary Medical Sciences, University of Bologna, 50 Via Tolara di Sopra, Ozzano dell’Emilia, BO 40064, Italy; Cotti, C., Department of Veterinary Medical Sciences, University of Bologna, 50 Via Tolara di Sopra, Ozzano dell’Emilia, BO 40064, Italy; Lelli, D., Virology Unit, Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna, 7/9 Via Bianchi, Brescia, 25124, Italy; Sozzi, E., Virology Unit, Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna, 7/9 Via Bianchi, Brescia, 25124, Italy; Trogu, T., Virology Unit, Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna, 7/9 Via Bianchi, Brescia, 25124, Italy; Lavazza, A., Virology Unit, Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna, 7/9 Via Bianchi, Brescia, 25124, Italy; Garuti, G., Department of Veterinary Medical Sciences, University of Bologna, 50 Via Tolara di Sopra, Ozzano dell’Emilia, BO 40064, Italy; Castrucci, M.R., Department of Infectious Diseases, Istituto Superiore di Sanità, 299 Viale Regina Elena, Rome, 00161, Italy; Vaccari, G., Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, 299 Viale Regina Elena, Rome, 00161, Italy; De Marco, M.A., Wildlife Service, Institute for Environmental Protection and Research (ISPRA), 9 Via Ca’ Fornacetta, Ozzano dell’Emilia, BO 40064, Italy; Moreno, A., Virology Unit, Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna, 7/9 Via Bianchi, Brescia, 25124, Italy","The Western European Hedgehog (Erinaceus europaeus) is one of the four hedgehog species belonging to the genus Erinaceus. Among them, E. amurensis is extant in East Asia’s areas only, whereas E. europaeus, E. roumanicus and E. concolor are mainly found in Europe. E. europaeus is endemically distributed from western to central and southern Europe, including Italy. Western European hedgehogs’ ecological and feeding habits, along with their high population densities, notable synanthropic attitudes, frequent contacts with sympatric wild and domestic species, including humans, implicate the possible involvement of E. europaeus in the ecology of potentially emerging viruses, such as coronaviruses, influenza A and influenza D viruses, canine distemper virus, pestiviruses and Aujeszky’s disease virus. We examined 24 E. europaeus individuals found injured in urban and rural areas of Northern Italy. Of the 24 fecal samples collected and tested for the above-mentioned pathogens by both PCR-based and virus isolation methods, 14 were found PCR-positive for betacoronaviruses belonging to lineage C and related to the known Erinaceus coronaviruses (EriCoVs), as determined by partial sequencing of the virus genome. Our findings suggest that hedgehogs could be considered natural reservoirs of CoVs, and also act as chronic shedding carriers of these potentially emerging RNA viruses. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.",Betacoronavirus infection; Coronaviruses; Erinaceus coronavirus (EriCoV); Hedgehogs; Public health; Wild animals,animal experiment; Article; canine distemper; Canine distemper virus; controlled study; Coronaviridae; feces analysis; gene sequence; hedgehog; Hericium erinaceus; Human parainfluenza virus 1; influenza A; Influenza A virus; Italy; nonhuman; Pestivirus; phylogenetic tree; phylogeny; prevalence; Pseudorabies virus; real time polymerase chain reaction; RNA virus; sequence analysis; virology; virus gene; virus genome; virus isolation; virus strain; virus transmission,"Douady, C.J., Chatelier, P.I., Madsen, O., de Jong, W.W., Catzeflis, F., Springer, M.S., Stanhope, M.J., Molecular phylogenetic evidence confirming the Eulipotyphla concept and in support of hedgehogs as the sister group to shrews (2002) Mol. Phylogenet. 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Microbiol., 40, pp. 3256-3260; Faccini, S., de Mattia, A., Chiapponi, C., Barbieri, I., Boniotti, M.B., Rosignoli, C., Franzini, G., Nigrelli, A.D., Development and evaluation of a new Real-Time RT-PCR assay for detection of proposed influenza D virus (2017) J. Virol. Methods, 243, pp. 31-34; Frisk, A.L., König, M., Moritz, A., Baumgärtner, W., Detection of canine distemper virus nucleoprotein RNA by reverse transcription-PCR using serum, whole blood, and cerebrospinal fluid from dogs with distemper (1999) J. Clin. Microbiol., 37, pp. 3634-3643; Yoon, H.A., Eo, S.K., Aleyas, A.G., Park, S.O., Lee, J.H., Chae, J.S., Cho, J.G., Song, H.J., Molecular survey of latent pseudorabies virus infection in nervous tissues of slaughtered pigs by nested and real-time PCR (2005) J. Microbiol., 43, pp. 430-436; Hoffmann, B., Beer, M., Schelp, C., Schirrmeier, H., Depner, K., Validation of a real-time RTPCR assay for sensitive and specific detection of classical swine fever (2005) J. Virol. Methods, 130, pp. 36-44; Chu, D.K., Leung, C.Y., Gilbert, M., Joyner, P.H., Ng, E.M., Tse, T.M., Guan, Y., Poon, L.L., Avian coronavirus in wild aquatic birds (2011) J. Virol., 85, pp. 12815-12820; Lelli, D., Papetti, A., Sabelli, C., Moreno, A., Boniotti, M.B., Detection of coronaviruses in bats of various species in Italy (2013) Viruses, 5, pp. 2679-2689; Nguyen, L.T., Schmidt, H.A., von Haeseler, A., Minh, B.Q., IQ-TREE: A fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies (2015) Mol. Biol. Evol., 32, pp. 268-274; Jeong, J., Smith, C.S., Peel, A.J., Plowright, R.K., Kerlin, D.H., McBroom, J., McCallum, H., Persistent infections support maintenance of a coronavirus in a population of Australian bats (Myotis macropus) (2017) Epidemiol. Infect., 145, pp. 2053-2061; Herrewegh, A.A., Mähler, M., Hedrich, H.J., Haagmans, B.L., Egberink, H.F., Horzinek, M.C., Rottier, P.J., de Groot, R.J., Persistence and evolution of feline coronavirus in a closed cat-breeding colony (1997) Virology, 234, pp. 349-363; Bouma, H.R., Carey, H.V., Kroese, F.G., Hibernation: The immune system at rest? (2010) Journal of Leukocyte Biology, 88, pp. 619-624; Su, S., Wong, G., Shi, W., Liu, J., Lai, A.C.K., Zhou, J., Liu, W., Gao, G.F., Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses (2016) Trends Microbiol, 24, pp. 490-502; Riley, P.Y., Chomel, B.B., Hedgehog zoonoses (2005) Emerg. Infect. Dis., 11, pp. 1-5; Lau, S.K.P., Luk, H.K.H., Wong, A.C.P., Fan, R.Y.Y., Lam, C.S.F., Li, K.S.M., Ahmed, S.S., Zhu, X., (2019) Identification of a Novel Betacoronavirus (Merbecovirus) in Amur Hedgehogs from China. Viruses, 11; Cannon, R.M., Roe, R.T., (1982) Livestock Disease Surveys: A Field Manual for Veterinarians. Australian Government Publishing Service: Canberra, Australia, pp. 1-35","De Marco, M.A.; Wildlife Service, Institute for Environmental Protection and Research (ISPRA), 9 Via Ca’ Fornacetta, Italy; email: mariaalessandra.demarco@isprambiente.it",,MDPI AG,20762615,,,,English,Animals,Article,Final,Open Access,Scopus,2-s2.0-85081139965,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Li C., Chen L.J., Chen X., Zhang M., Pang C.P., Chen H.",57212109862;57215829867;57215830643;57215828312;57215604272;57215611618;,"Retrospective analysis of the possibility of predicting the COVID-19 outbreak from Internet searches and social media data, China, 2020",2020,Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin,25,10,,,,,,10.2807/1560-7917.ES.2020.25.10.2000199,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081997309&doi=10.2807%2f1560-7917.ES.2020.25.10.2000199&partnerID=40&md5=51fc3b6cee834e8e5815faa25a1d9437,"Joint Shantou International Eye Center, Shantou University and the Chinese University of Hong Kong, Shantou, China; Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong, China","Li, C., Joint Shantou International Eye Center, Shantou University and the Chinese University of Hong Kong, Shantou, China; Chen, L.J., Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong, China; Chen, X., Joint Shantou International Eye Center, Shantou University and the Chinese University of Hong Kong, Shantou, China; Zhang, M., Joint Shantou International Eye Center, Shantou University and the Chinese University of Hong Kong, Shantou, China; Pang, C.P., Joint Shantou International Eye Center, Shantou University and the Chinese University of Hong Kong, Shantou, China, Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong, China; Chen, H., Joint Shantou International Eye Center, Shantou University and the Chinese University of Hong Kong, Shantou, China","The peak of Internet searches and social media data about the coronavirus disease 2019 (COVID-19) outbreak occurred 10-14 days earlier than the peak of daily incidences in China. Internet searches and social media data had high correlation with daily incidences, with the maximum r > 0.89 in all correlations. The lag correlations also showed a maximum correlation at 8-12 days for laboratory-confirmed cases and 6-8 days for suspected cases.",Baidu Index; coronavirus; COVID-19; Google Trends; Internet surveillance; Weibo Index,"COVID-19; China; Coronavirus infection; epidemic; health survey; human; incidence; Internet; laboratory; procedures; public health service; search engine; social media; virus pneumonia; web browser; China; Coronavirus Infections; Disease Outbreaks; Humans; Incidence; Internet; Laboratories; Pneumonia, Viral; Population Surveillance; Public Health Practice; Search Engine; Social Media; Web Browser",,,,NLM (Medline),15607917,,,32183935,English,Euro Surveill.,Article,Final,Open Access,Scopus,2-s2.0-85081997309,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Johnson H.C., Gossner C.M., Colzani E., Kinsman J., Alexakis L., Beauté J., Würz A., Tsolova S., Bundle N., Ekdahl K.",57215688627;35763751200;23476360100;57215691284;57215688260;26323555200;15729847900;15020090900;57193089832;7004921710;,"Potential scenarios for the progression of a COVID-19 epidemic in the European Union and the European Economic Area, March 2020",2020,Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin,25,9,,,,,,10.2807/1560-7917.ES.2020.25.9.2000202,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081674537&doi=10.2807%2f1560-7917.ES.2020.25.9.2000202&partnerID=40&md5=62534f940053862406bb544af598eeb5,"These authors contributed equally; European Centre for Disease Prevention and Control, Solna, Sweden","Johnson, H.C., These authors contributed equally, European Centre for Disease Prevention and Control, Solna, Sweden; Gossner, C.M., These authors contributed equally, European Centre for Disease Prevention and Control, Solna, Sweden; Colzani, E., European Centre for Disease Prevention and Control, Solna, Sweden; Kinsman, J., European Centre for Disease Prevention and Control, Solna, Sweden; Alexakis, L., European Centre for Disease Prevention and Control, Solna, Sweden; Beauté, J., European Centre for Disease Prevention and Control, Solna, Sweden; Würz, A., European Centre for Disease Prevention and Control, Solna, Sweden; Tsolova, S., European Centre for Disease Prevention and Control, Solna, Sweden; Bundle, N., European Centre for Disease Prevention and Control, Solna, Sweden; Ekdahl, K., European Centre for Disease Prevention and Control, Solna, Sweden","Two months after the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the possibility of established and widespread community transmission in the European Union and European Economic Area (EU/EEA) is becoming more likely. We provide scenarios for use in preparedness for a possible widespread epidemic. The EU/EEA is moving towards the 'limited sustained transmission' phase. We propose actions to prepare for potential mitigation phases and coordinate efforts to protect the health of citizens.",coronavirus; COVID-19; Europe; pandemic; preparedness; SARS-CoV-2,"COVID-19; severe acute respiratory syndrome coronavirus 2; aged; Betacoronavirus; comorbidity; Coronavirus infection; disaster planning; epidemic; Europe; European Union; forecasting; health care planning; human; international cooperation; middle aged; pathogenicity; public health; risk factor; theoretical model; uncertainty; very elderly; virus pneumonia; Aged; Aged, 80 and over; Betacoronavirus; Comorbidity; Coronavirus Infections; Disaster Planning; Epidemics; Europe; European Union; Forecasting; Health Planning; Humans; Internationality; Middle Aged; Models, Theoretical; Pneumonia, Viral; Public Health; Risk Factors; Uncertainty",,,,NLM (Medline),15607917,,,32156332,English,Euro Surveill.,Article,Final,Open Access,Scopus,2-s2.0-85081674537,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Haveri A., Smura T., Kuivanen S., Österlund P., Hepojoki J., Ikonen N., Pitkäpaasi M., Blomqvist S., Rönkkö E., Kantele A., Strandin T., Kallio-Kokko H., Mannonen L., Lappalainen M., Broas M., Jiang M., Siira L., Salminen M., Puumalainen T., Sane J., Melin M., Vapalahti O., Savolainen-Kopra C.",15762492500;16029436500;55388841000;6602837015;6504046009;6506707870;57215357809;7004588653;8510475000;7004712967;8639437300;6603220153;6604083713;7003535244;12788078100;57215924776;21234330300;7006113679;16307625800;35108019500;23474596000;7003800146;24512588600;,"Serological and molecular findings during SARS-CoV-2 infection: the first case study in Finland, January to February 2020",2020,Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin,25,11,,,,,,10.2807/1560-7917.ES.2020.25.11.2000266,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082380999&doi=10.2807%2f1560-7917.ES.2020.25.11.2000266&partnerID=40&md5=a224b764b33af5f2ac5d52eb0f12e2c3,"Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland; University of Helsinki, Medicum, Department of Virology, Helsinki, Finland; Institute of Veterinary Pathology, Vetsuisse Faculty, University of ZürichZürich, Switzerland; Inflammation Center, Infectious Diseases, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki, Finland; Department of Virology and Immunology, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki, Finland; Infection-Hospital Hygiene Unit, Lapland Central Hospital, Rovaniemi, Finland; Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland","Haveri, A., Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland; Smura, T., University of Helsinki, Medicum, Department of Virology, Helsinki, Finland; Kuivanen, S., University of Helsinki, Medicum, Department of Virology, Helsinki, Finland; Österlund, P., Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland; Hepojoki, J., University of Helsinki, Medicum, Department of Virology, Helsinki, Finland, Institute of Veterinary Pathology, Vetsuisse Faculty, University of ZürichZürich, Switzerland; Ikonen, N., Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland; Pitkäpaasi, M., Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland; Blomqvist, S., Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland; Rönkkö, E., Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland; Kantele, A., Inflammation Center, Infectious Diseases, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki, Finland; Strandin, T., University of Helsinki, Medicum, Department of Virology, Helsinki, Finland; Kallio-Kokko, H., Department of Virology and Immunology, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki, Finland; Mannonen, L., Department of Virology and Immunology, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki, Finland; Lappalainen, M., Department of Virology and Immunology, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki, Finland; Broas, M., Infection-Hospital Hygiene Unit, Lapland Central Hospital, Rovaniemi, Finland; Jiang, M., Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland, Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland; Siira, L., Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland; Salminen, M., Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland; Puumalainen, T., Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland; Sane, J., Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland; Melin, M., Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland; Vapalahti, O., University of Helsinki, Medicum, Department of Virology, Helsinki, Finland, Department of Virology and Immunology, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki, Finland; Savolainen-Kopra, C., Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland","The first case of coronavirus disease (COVID-19) in Finland was confirmed on 29 January 2020. No secondary cases were detected. We describe the clinical picture and laboratory findings 3-23 days since the first symptoms. The SARS-CoV-2/Finland/1/2020 virus strain was isolated, the genome showing a single nucleotide substitution to the reference strain from Wuhan. Neutralising antibody response appeared within 9 days along with specific IgM and IgG response, targeting particularly nucleocapsid and spike proteins.",antibodies; coronavirus; COVID-19; humoral immunity; immunofluorescence assay; microneutralisation test; SARS-CoV-2; western blotting; whole-genome sequencing,,,,,NLM (Medline),15607917,,,32209163,English,Euro Surveill.,Article,Final,Open Access,Scopus,2-s2.0-85082380999,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wang L.-S., Hu X.-J., Zhou W.-H.",7409189360;57215894842;57215893363;,An interpretation on perinatal and neonatal management plan for prevention and control of SARS-CoV-2 infection (2nd Edition),2020,Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics,22,3,,199,204,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082271268&partnerID=40&md5=6fd401f482ab4487677bd5b2795e8d71,"National Children's Medical Center/Department of Neonatology, Children's Hospital of Fudan UniversityShanghai 201102, China","Wang, L.-S., National Children's Medical Center/Department of Neonatology, Children's Hospital of Fudan UniversityShanghai 201102, China; Hu, X.-J.; Zhou, W.-H.","The epidemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection continues so far. The cases of SARS-CoV-2 infection have been reported in pregnant women and neonates as special groups. Perinatal and neonatal management plan for prevention and control of SARS-CoV-2 infection (2nd Edition) has been worked out by the Editorial Committee of Chinese Journal of Contemporary Pediatrics. This paper presents an interpretation on the 2nd Edition of the management plan, so as to facilitate readers to better understand it.",,"Betacoronavirus; Coronavirus infection; female; human; newborn; perinatal care; pregnancy; virus pneumonia; Betacoronavirus; Coronavirus Infections; Female; Humans; Infant, Newborn; Perinatal Care; Pneumonia, Viral; Pregnancy",,,,NLM (Medline),10088830,,,32204753,Chinese,Zhongguo Dang Dai Er Ke Za Zhi,Article,Final,,Scopus,2-s2.0-85082271268,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Catton H.,6506434585;,Global challenges in health and health care for nurses and midwives everywhere,2020,International nursing review,67,1,,4,6,,,10.1111/inr.12578,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080847870&doi=10.1111%2finr.12578&partnerID=40&md5=458f933a1c8ec8d815d47f6845f7bfe4,"International Council of NursesGeneva, Switzerland","Catton, H., International Council of NursesGeneva, Switzerland","The next decade is likely to produce any number of global challenges that will affect health and health care, including pan-national infections such as the new coronavirus COVID-19 and others that will be related to global warming. Nurses will be required to react to these events, even though they will also be affected as ordinary citizens. The future resilience of healthcare services will depend on having sufficient numbers of nurses who are adequately resourced to face the coming challenges. © 2020 International Council of Nurses.",climate change; coronavirus; COVID-19 recruitment and retention; Year of the Nurse and Midwife,female; global health; health care delivery; human; midwife; nurse midwife; pregnancy; Delivery of Health Care; Female; Global Health; Humans; Midwifery; Nurse Midwives; Pregnancy,,,,NLM (Medline),14667657,,,32083728,English,Int Nurs Rev,Article,Final,Open Access,Scopus,2-s2.0-85080847870,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Atluri S., Manchikanti L., Hirsch J.A.",7103181435;7005065169;57193113369;,Expanded Umbilical Cord Mesenchymal Stem Cells (UC-MSCs) as a Therapeutic Strategy in Managing Critically Ill COVID-19 Patients: The Case for Compassionate Use,2020,Pain physician,23,2,,E71,E83,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082491072&partnerID=40&md5=6dc2bef1d4369b2d4ae0c9d9b011ae09,"Tri State Spine Care Institute; Pain Management Centers of America, Paducah, KY and Evansville, IN; LSU Health Science Center, New Orleans, LA; Massachusetts General Hospital and Harvard Medical School, MA, Boston","Atluri, S., Tri State Spine Care Institute; Manchikanti, L., Pain Management Centers of America, Paducah, KY and Evansville, IN; LSU Health Science Center, New Orleans, LA; Hirsch, J.A., Massachusetts General Hospital and Harvard Medical School, MA, Boston","COVID-19 has affected the United States leading to a national emergency with health care and economic impact, propelling the country into a recession with disrupted lifestyles not seen in recent history. COVID-19 is a serious illness leading to multiple deaths in various countries including the United States. Several million Americans satisfy the Center for Disease Control and Prevention (CDC) criteria for being high risk. Unfortunately, the available supply of medical beds and equipment for mechanical ventilation are much less than is projected to be needed. The World Health Organization (WHO) and multiple agencies led by the CDC in the United States have attempted to organize intensive outbreak investigation programs utilizing appropriate preventive measures, evaluation, and treatment. The clinical spectrum of COVID-19 varies from asymptomatic forms to conditions encompassing multiorgan and systemic manifestations in terms of septic shock, and multiple organ dysfunction (MOD) syndromes. The presently approved treatments are supportive but not curative for the disease. There are multiple treatments being studied. These include vaccines, medications Remdesivir and hydroxychloroquine and potentially combination therapy. Finally, expanded umbilical cord mesenchymal stem cells or (UC-MSCs) may have a role and are being studied. The cure of COVID-19 is essentially dependent on the patients' own immune system. When the immune system is over activated in an attempt to kill the virus, this can lead to the production of a large number of inflammatory factors, resulting in severe cytokine storm. The cytokine storm may induce organ damage followed by the edema, dysfunction of air exchange, acute respiratory distress syndrome (ARDS), acute cardiac injury, and secondary infection, which may lead to death. Thus, at this point, the avoidance of the cytokine storm may be the key for the treatment of HCOV-19 infected patients.In China, where there was limited availability of effective modalities to manage COVID-19 several patients were treated with expanded UC-MSCs. Additionally, the Italian College of Anesthesia, Analgesia, Resuscitation and Intensive Care have reported guidelines to treat coronavirus patients with stem cells in the hope of decreasing the number of patients going to the ICU, and, also relatively quickly getting them out of ICU. In this manuscript, we describe the urgent need for various solutions, pathogenesis of coronavirus and the clinical evidence for treatment of COVID-19 with stem cells. The limited but emerging evidence regarding UC MSC in managing COVID-19 suggests that it might be considered for compassionate use in critically ill patients to reduce morbidity and mortality in the United States. The administration and Coronavirus Task Force might wish to approach the potential of expanded UC-MSCs as an evolutionary therapeutic strategy in managing COVID-19 illness with a 3-pronged approach: If proven safe and effective on a specific and limited basis…1. Minimize regulatory burden by all agencies so that critically ill COVID-19 patients will have access regardless of their financial circumstance.2. Institute appropriate safeguards to avoid negative consequences from unscrupulous actors.3. With proper informed consent from patients or proxy when necessary, and subject to accumulation of data in that cohort, allow the procedure to be initiated in critically ill patients who are not responding to conventional therapies.KEY WORDS: Coronavirus, COVID-19, cytokine storm, multiorgan failure, expanded umbilical cord mesenchymal stem cells.",,,,,,NLM (Medline),21501149,,,32214286,English,Pain Physician,Article,Final,,Scopus,2-s2.0-85082491072,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Moreno-Montoya J.,57195375416;,The challenge of communicating and controlling the coronavirus epidemic [El desafío de comunicar y controlar la epidemia por coronavirus],2020,Biomedica : revista del Instituto Nacional de Salud,40,1,,11,13,,,10.7705/biomedica.5455,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082561705&doi=10.7705%2fbiomedica.5455&partnerID=40&md5=13354e446721e5764b50d2ffdc0aeb6b,"Fundación Santa Fe de Bogotá; Editor asociado, Biomédica. josemorenomontoya@gmail.com","Moreno-Montoya, J., Fundación Santa Fe de Bogotá; Editor asociado, Biomédica. josemorenomontoya@gmail.com",[No abstract available],,,,,,NLM (Medline),1204157,,,32220158,English; Spanish,Biomedica,Article,Final,Open Access,Scopus,2-s2.0-85082561705,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Naviaux A.-F., Janne P., Gourdin M.",6507492780;56247749300;56016075100;,Medico-psychological aspects relating to the coronavirus epidemic (Covid-19): The contribution of the theory of signal detection and the concept of place of control [Aspects médico-psychologiques relatifs à l’épidémie de coronavirus (Covid-19) : l'apport de la théorie de la détection du signal et du concept de lieu de contrôle],2020,Annales Medico-Psychologiques,178,3,,223,225,,,10.1016/j.amp.2020.03.001,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082553194&doi=10.1016%2fj.amp.2020.03.001&partnerID=40&md5=f1e2fbdbfcdd0f2d39fe1bafed35854b,"Health Service Executive (HSE) Summerhill Community Mental Health Service, Summerhill, Wexford, Y35 KC58, Ireland; Université catholique de Louvain, CHU UCL Namur, avenue Dr-G.-Thérasse, Yvoir, 5530, Belgium; Faculty of Psychology, Université catholique de Louvain, place Cardinal-Mercier 10, Ottignies-Louvain-la-Neuve, 1348, Belgium; Faculty of Medicine, Université catholique de Louvain, avenue Emmanuel-Mounier 50, Woluwé-Saint-Lambert, 1200, Belgium","Naviaux, A.-F., Health Service Executive (HSE) Summerhill Community Mental Health Service, Summerhill, Wexford, Y35 KC58, Ireland, Faculty of Medicine, Université catholique de Louvain, avenue Emmanuel-Mounier 50, Woluwé-Saint-Lambert, 1200, Belgium; Janne, P., Université catholique de Louvain, CHU UCL Namur, avenue Dr-G.-Thérasse, Yvoir, 5530, Belgium, Faculty of Psychology, Université catholique de Louvain, place Cardinal-Mercier 10, Ottignies-Louvain-la-Neuve, 1348, Belgium; Gourdin, M., Université catholique de Louvain, CHU UCL Namur, avenue Dr-G.-Thérasse, Yvoir, 5530, Belgium, Faculty of Medicine, Université catholique de Louvain, avenue Emmanuel-Mounier 50, Woluwé-Saint-Lambert, 1200, Belgium",[No abstract available],Comportement; Coronavirus; Covid-19; Health locus of control; Pandemic; Signal detection theory,,"Berle, D., Starcevic, V., Khazaal, Y., Viswasam, K., Hede, V., McMullan, R.D., Relationships between online health information seeking and psychopathology (2019) Gen Hosp Psychiatry; Cascella, M., Rajnik, M., Cuomo, A., Dulebohn, S.C., Di Napoli, R., Features, Evaluation and Treatment Coronavirus (COVID-19) (2020), StatPearls Publishing StatPearls Publishing LLC StatPearls. Treasure Island (FL); Cimiotti, J.P., Aiken, L.H., Sloane, D.M., Wu, E.S., Nurse staffing, burnout, and health care-associated infection (2012) Am J Infect Control, 40, pp. 486-490; Fergus, T.A., Spada, M.M., Cyberchondria: examining relations with problematic Internet use and metacognitive beliefs (2017) Clin Psychol Psychother, 24, pp. 1322-1330; Hageman, J.R., The Coronavirus Disease 2019 (COVID-19) (2020) Pediatr Ann, 49. , e99-e100; Jekel, M., Empirical content as a criterion for evaluating models (2019) Cogn Process, 20, pp. 273-275; Legido-Quigley, H., Asgari, N., Teo, Y.Y., Leung, G.M., Oshitani, H., Fukuda, K., Are high-performing health systems resilient against the COVID-19 epidemic? (2020) Lancet; Lepeltier, T., La Logique de la découverte scientifique, de Karl Popper. Histoire et philosophie des sciences (2013), p. 152. , Éditions Sciences Humaines Auxerre; Lynn, S.K., Barrett, L.F., “Utilizing” signal detection theory (2014) Psychol Sci, 25, pp. 1663-1673; Martin, J., Dube, C., Coovert, M.D., Signal Detection Theory (SDT) is effective for modeling user behavior toward phishing and spear-phishing attacks (2018) Hum Factors, 60, pp. 1179-1191; N.E. Logik der Forschung (1935) J Philos, 32, pp. 107-108; Sun, P., Lu, X., Xu, C., Sun, W., Pan, B., Understanding of COVID-19 based on current evidence (2020) J Med Virol; Velavan, T.P., Meyer, C.G., The COVID-19 epidemic (2020) Trop Med Int Health, 25, pp. 278-280; Xu, Y., Unveiling the Origin and Transmission of 2019-nCoV (2020) Trends Microbiol, 28, pp. 239-240; Yao, N., Wang, S.N., Lian, J.Q., Sun, Y.T., Zhang, G.F., Kang, W.Z., Clinical characteristics and influencing factors of patients with novel coronavirus pneumonia combined with liver injury in Shaanxi region (2020) Zhonghua Gan Zang Bing Za Zhi, 28, p. E003","Janne, P.; Université catholique de Louvain, CHU UCL Namur, avenue Dr-G.-Thérasse, Belgium; email: pascal.janne@uclouvain.be",,Elsevier Masson SAS,34487,,AMPYA,,English; French,Ann. Med.-Psychol.,Letter,Final,Open Access,Scopus,2-s2.0-85082553194,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Pires da Rosa G., Ferreira E.",56669867600;57216075639;,Therapies used in rheumatology with relevance to coronavirus disease 2019,2020,Clinical and experimental rheumatology,38,2,,370,,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082542535&partnerID=40&md5=a5e328aa3a5425c1bf235151775fe465,"Autoimmune Diseases Consultation, Department of Internal Medicine, Hospital Lusíadas Porto, Faculty of Medicine, University of Porto, Portugal; Faculty of Medicine, University of Porto, Autoimmune Diseases Group, Department of Internal Medicine, Centro Hospitalar Universitário de São JoãoPorto, Portugal","Pires da Rosa, G., Autoimmune Diseases Consultation, Department of Internal Medicine, Hospital Lusíadas Porto, Faculty of Medicine, University of Porto, Portugal; Ferreira, E., Faculty of Medicine, University of Porto, Autoimmune Diseases Group, Department of Internal Medicine, Centro Hospitalar Universitário de São JoãoPorto, Portugal",[No abstract available],,,,,,NLM (Medline),0392856X,,,32202241,English,Clin. Exp. Rheumatol.,Letter,Final,,Scopus,2-s2.0-85082542535,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Cataletto M.,6603228272;,Global Spread of Coronavirus: Preparing Health Care Workers,2020,"Pediatric, Allergy, Immunology, and Pulmonology",33,1,,1,,,,10.1089/ped.2020.29001.mca,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082536490&doi=10.1089%2fped.2020.29001.mca&partnerID=40&md5=b4f14b5ef3481cdfa2071abaf03c3795,"Department of Clinical Pediatrics, State University of New York at Stony Brook, Stony Brook, NY, United States","Cataletto, M., Department of Clinical Pediatrics, State University of New York at Stony Brook, Stony Brook, NY, United States",[No abstract available],,,,"Cataletto, M.; Department of Clinical Pediatrics, State University of New York at Stony BrookUnited States",,Mary Ann Liebert Inc.,2151321X,,PAAIE,,English,Pediatr. Allergy Immunol. Pulmonol.,Editorial,Final,,Scopus,2-s2.0-85082536490,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Springer Medizin,,Coronavirus-Pandemie: So werden die Leistungen am Patienten vergütet : Wie Sie an das extrabudgetäre Honorar kommen,2020,MMW Fortschritte der Medizin,162,,,26,,,,10.1007/s15006-020-0298-x,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082514598&doi=10.1007%2fs15006-020-0298-x&partnerID=40&md5=6ed31159a5eec34a0671d0c0e74eaa54,,Springer Medizin,[No abstract available],,,,,,NLM (Medline),16133560,,,32221882,German,MMW Fortschr Med,Article,Final,,Scopus,2-s2.0-85082514598,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Zimmermann G.W.,8885194600;,Coronavirus: Schutzkleidung wird zentral bestellt und bezahlt : Infektionsschutz,2020,MMW Fortschritte der Medizin,162,,,24,,,,10.1007/s15006-020-0296-z,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082507639&doi=10.1007%2fs15006-020-0296-z&partnerID=40&md5=b9c9af71673159938e1eb11a50fa60e7,"Kapellenstraße 9D-65719, Germany","Zimmermann, G.W., Kapellenstraße 9D-65719, Germany",[No abstract available],,,,,,NLM (Medline),16133560,,,32221884,German,MMW Fortschr Med,Article,Final,,Scopus,2-s2.0-85082507639,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, [No author name available],[No author id available],"Covert coronavirus, chaos prize and the cost of contact-tracing",2020,Nature,579,7800,,477,,,,10.1038/d41586-020-00829-4,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082506356&doi=10.1038%2fd41586-020-00829-4&partnerID=40&md5=9c008a53d443f97227f4882ab50d59f0,,,[No abstract available],Infection; Mathematics and computing; Public health,,,,,NLM (Medline),14764687,,,32214268,English,Nature,Note,Final,Open Access,Scopus,2-s2.0-85082506356,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Hönemann M., Lübbert C., Liebert U.G.",57210415389;18437415800;7003578613;,Neuartiges Coronavirus (SARS-CoV-2),2020,Zeitschrift fur Gastroenterologie,58,3,,213,214,,,10.1055/a-1134-6010,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082489522&doi=10.1055%2fa-1134-6010&partnerID=40&md5=b3f964e13fdecbdcbeacdea3a99b8819,"Institut für Virologie, Medizinische Klinik II, Bereich Infektions- und Tropenmedizin, Universitätsklinikum Leipzig, Zentrum für Infektionsmedizin, Germany","Hönemann, M., Institut für Virologie, Medizinische Klinik II, Bereich Infektions- und Tropenmedizin, Universitätsklinikum Leipzig, Zentrum für Infektionsmedizin, Germany; Lübbert, C., Institut für Virologie, Medizinische Klinik II, Bereich Infektions- und Tropenmedizin, Universitätsklinikum Leipzig, Zentrum für Infektionsmedizin, Germany; Liebert, U.G., Institut für Virologie, Medizinische Klinik II, Bereich Infektions- und Tropenmedizin, Universitätsklinikum Leipzig, Zentrum für Infektionsmedizin, Germany",[No abstract available],,,"Holshue, M., Debolt, C., Lindquist, S., First Case of 2019 Novel Coronavirus in the United States (2020) N Engl J Med",,,Georg Thieme Verlag,442771,,ZGASA,,German,Z. Gastroenterol.,Note,Final,Open Access,Scopus,2-s2.0-85082489522,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Hancocks OBE S.,57210146925;,Coronavirus and a greener future,2020,British Dental Journal,228,6,,393,,,,10.1038/s41415-020-1432-y,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082469463&doi=10.1038%2fs41415-020-1432-y&partnerID=40&md5=4aac3a96fc69d58426d9383e624af70e,"Editor-in-chief, London, United Kingdom","Hancocks OBE, S., Editor-in-chief, London, United Kingdom",[No abstract available],,,,"Hancocks OBE, S.; Editor-in-chiefUnited Kingdom",,Springer Nature,70610,,,32221416,English,Brit. Dent. J.,Editorial,Final,Open Access,Scopus,2-s2.0-85082469463,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Gern K.-J., Hauber P.",14624868400;56592918900;,Business cycle highlight: Coronavirus keeps the global economy in suspense [Coronavirus hält Weltkonjunktur in Atem],2020,Wirtschaftsdienst,100,3,,223,224,,,10.1007/s10273-020-2607-5,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082447492&doi=10.1007%2fs10273-020-2607-5&partnerID=40&md5=2784a4ff03cc5a5999b1275515c8bba3,"Forschungsgruppe Intern. Konjunktur, Institut für Weltwirtschaft, Kiellinie 66, Kiel, 24105, Germany; Prognosezentrum, Institut für Weltwirtschaft, Kiellinie 66, Kiel, 24105, Germany","Gern, K.-J., Forschungsgruppe Intern. Konjunktur, Institut für Weltwirtschaft, Kiellinie 66, Kiel, 24105, Germany; Hauber, P., Prognosezentrum, Institut für Weltwirtschaft, Kiellinie 66, Kiel, 24105, Germany",[No abstract available],,,,"Gern, K.-J.; Forschungsgruppe Intern. Konjunktur, Institut für Weltwirtschaft, Kiellinie 66, Germany; email: klaus-juergen.gern@ifw-kiel.de",,Springer,436275,,,,German,Wirtschaftsdienst,Article,Final,Open Access,Scopus,2-s2.0-85082447492,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Cyranoski D.,57208765775;,What China's coronavirus response can teach the rest of the world,2020,Nature,579,7800,,479,480,,,10.1038/d41586-020-00741-x,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082384413&doi=10.1038%2fd41586-020-00741-x&partnerID=40&md5=2eb2692d8cae6cdb374cc129e5a206a5,,"Cyranoski, D.",[No abstract available],Government; Infection; Public health,,,,,NLM (Medline),14764687,,,32203360,English,Nature,Note,Final,Open Access,Scopus,2-s2.0-85082384413,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Maxmen A.,36867482000;,Scientists exposed to coronavirus wonder: why weren't we notified?,2020,Nature,579,7800,,480,481,,,10.1038/d41586-020-00823-w,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082380907&doi=10.1038%2fd41586-020-00823-w&partnerID=40&md5=25947f2aa609978310d17dfb07525043,,"Maxmen, A.",[No abstract available],Ebola virus; Genomics; Infection; Virology,,,,,NLM (Medline),14764687,,,32203382,English,Nature,Note,Final,,Scopus,2-s2.0-85082380907,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Callaway E.,23975660600;,Coronavirus vaccines: five key questions as trials begin,2020,Nature,579,7800,,481,,,,10.1038/d41586-020-00798-8,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082380808&doi=10.1038%2fd41586-020-00798-8&partnerID=40&md5=4bea5faa4fd442cafa7409883719328b,,"Callaway, E.",[No abstract available],Infection; Virology,,,,,NLM (Medline),14764687,,,32203367,English,Nature,Note,Final,Open Access,Scopus,2-s2.0-85082380808,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Callaway E., Cyranoski D., Mallapaty S., Stoye E., Tollefson J.",23975660600;57208765775;55683091500;55861836200;25032277400;,The coronavirus pandemic in five powerful charts,2020,Nature,579,7800,,482,483,,,10.1038/d41586-020-00758-2,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082380150&doi=10.1038%2fd41586-020-00758-2&partnerID=40&md5=56af2eafd13dfce79553175e1c4527a8,,"Callaway, E.; Cyranoski, D.; Mallapaty, S.; Stoye, E.; Tollefson, J.",[No abstract available],Diseases; Infection,,,,,NLM (Medline),14764687,,,32203366,English,Nature,Note,Final,Open Access,Scopus,2-s2.0-85082380150,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Ceccarelli M., Berretta M., Venanzi Rullo E., Nunnari G., Cacopardo B.",54398201900;6604062299;57188956138;35311650300;7003926073;,Differences and similarities between Severe Acute Respiratory Syndrome (SARS)-CoronaVirus (CoV) and SARS-CoV-2. Would a rose by another name smell as sweet?,2020,European review for medical and pharmacological sciences,24,5,,2781,2783,,,10.26355/eurrev_202003_20551,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082146253&doi=10.26355%2feurrev_202003_20551&partnerID=40&md5=33c108c03e850df0c457671b381b25f2,"Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy","Ceccarelli, M., Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy; Berretta, M.; Venanzi Rullo, E.; Nunnari, G.; Cacopardo, B.",[No abstract available],,"Betacoronavirus; Coronavirus infection; differential diagnosis; human; pathogenicity; risk factor; SARS coronavirus; severe acute respiratory syndrome; virus pneumonia; Betacoronavirus; Coronavirus Infections; Diagnosis, Differential; Humans; Pneumonia, Viral; Risk Factors; SARS Virus; Severe Acute Respiratory Syndrome",,,,NLM (Medline),22840729,,,32196628,English,Eur Rev Med Pharmacol Sci,Editorial,Final,,Scopus,2-s2.0-85082146253,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Guan L., Zhou L., Zhang J., Peng W., Chen R.",57215851368;56518530300;23973753700;57215188958;57200034537;,More awareness is needed for severe acute respiratory syndrome coronavirus 2019 transmission through exhaled air during non-invasive respiratory support: Experience from China,2020,European Respiratory Journal,55,3,2000352,,,,,10.1183/13993003.00352-2020,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082092531&doi=10.1183%2f13993003.00352-2020&partnerID=40&md5=987fdafcd6aef145a665c2fa4f506b81,"State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Dept of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Division of ICU and Respiratory Service, Dept of Internal Medicine, Salt Lake Regional Medical Center, Heart and Lung Institute of Utah, Salt Lake City, UT, United States; Dept of Respiratory and Critical Care Medicine, Southern University of Science and Technology, Second Clinical Medical College of Jinan University, Shenzhen People’s Hospital, Shenzhen Institute of Respiratory Diseases, 1017 Dong Men Road, Shenzhen, 518020, China","Guan, L., State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Zhou, L., State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Zhang, J., Dept of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Peng, W., Division of ICU and Respiratory Service, Dept of Internal Medicine, Salt Lake Regional Medical Center, Heart and Lung Institute of Utah, Salt Lake City, UT, United States; Chen, R., State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China, Dept of Respiratory and Critical Care Medicine, Southern University of Science and Technology, Second Clinical Medical College of Jinan University, Shenzhen People’s Hospital, Shenzhen Institute of Respiratory Diseases, 1017 Dong Men Road, Shenzhen, 518020, China",[No abstract available],,"Betacoronavirus; Coronavirus infection; human; mask; microbiology; noninvasive ventilation; virus pneumonia; Air Microbiology; Betacoronavirus; Coronavirus Infections; Humans; Masks; Noninvasive Ventilation; Pneumonia, Viral","Novel Coronavirus (2019-nCoV), , www.who.int/docs/default-source/coronaviruse/situation-reports/20200217-sitrep-28-covid-19.pdf?sfvrsn=a19cf2ad_2, Situation Report—28 Feb 17, 2020. Date last updated: 17 February, 2020. Date last accessed: 17 February 2020; The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China] (in Chinese) (2020) Zhonghua Liu Xing Bing Xue Za Zhi, 41, pp. 145-151; Wang, D., Hu, B., Hu, C., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China JAMA, 2020. , https://doi.org/10.1001/jama.2020.1585, press; Simonds, A.K., Hanak, A., Chatwin, M., Evaluation of droplet dispersion during non-invasive ventilation, oxygen therapy, nebuliser treatment and chest physiotherapy in clinical practice: Implications for management of pandemic influenza and other airborne infections (2010) Health Technol Assess, 14, pp. 131-172; Hui, D.S., Chow, B.K., Lo, T., Exhaled air dispersion during high-flow nasal cannula therapy versus CPAP via different masks (2019) Eur Respir J, 53, p. 1802339; Hui, D.S., Chow, B.K., Lo, T., Exhaled air dispersion during noninvasive ventilation via helmets and a total facemask (2015) Chest, 147, pp. 1336-1343; Infection Prevention and Control during Health Care When Novel Coronavirus (nCoV) Infection Is Suspected, , www.who.int/publications-detail/infection-prevention-and-control-during-health-care-whennovel-coronavirus-(ncov)-infection-is-suspected-20200125, Date last updated: 25 January, 2020. Date last accessed: 17 February, 2020","Chen, R.; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical UniversityChina; email: chenrc@vip.163.com",,European Respiratory Society,9031936,,ERJOE,32198275,English,Eur. Respir. J.,Letter,Final,Open Access,Scopus,2-s2.0-85082092531,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, [No author name available],[No author id available],"Coronavirus vaccine trial, Mars rover delay and a boost for UK science",2020,Nature,579,7799,,324,325,,,10.1038/d41586-020-00752-8,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082074955&doi=10.1038%2fd41586-020-00752-8&partnerID=40&md5=7d43ddcba8769375c5dafbd9cc29c6f9,,,[No abstract available],Diseases; Funding; Peer review; Planetary science,,,,,NLM (Medline),14764687,,,32188956,English,Nature,Note,Final,Open Access,Scopus,2-s2.0-85082074955,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Mizumoto K., Kagaya K., Zarebski A., Chowell G.",55553077000;57213186397;57160212700;9845935500;,"Estimating the asymptomatic proportion of coronavirus disease 2019 (COVID-19) cases on board the Diamond Princess cruise ship, Yokohama, Japan, 2020",2020,Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin,25,10,,,,,,10.2807/1560-7917.ES.2020.25.10.2000180,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082063395&doi=10.2807%2f1560-7917.ES.2020.25.10.2000180&partnerID=40&md5=821e34f7daba09c68906a286669dc6d3,"Department of Population Health Sciences, School of Public Health, Georgia State University, Atlanta, GA, United States; Hakubi Center for Advanced Research, Kyoto University, Yoshidahonmachi ,Sakyo-kuKyoto, Japan; Graduate School of Advanced Integrated Studies in Human Survivability, Kyoto University Yoshida-Nakaadachi-cho, Sakyo-kuKyoto, Japan; Seto Marine Biological Laboratory, Field Science, Education and Reseach Center, Kyoto UniversityWakayama, Japan; Department of Zoology, University of Oxford, Oxford, United Kingdom","Mizumoto, K., Department of Population Health Sciences, School of Public Health, Georgia State University, Atlanta, GA, United States, Hakubi Center for Advanced Research, Kyoto University, Yoshidahonmachi ,Sakyo-kuKyoto, Japan, Graduate School of Advanced Integrated Studies in Human Survivability, Kyoto University Yoshida-Nakaadachi-cho, Sakyo-kuKyoto, Japan; Kagaya, K., Hakubi Center for Advanced Research, Kyoto University, Yoshidahonmachi ,Sakyo-kuKyoto, Japan, Seto Marine Biological Laboratory, Field Science, Education and Reseach Center, Kyoto UniversityWakayama, Japan; Zarebski, A., Department of Zoology, University of Oxford, Oxford, United Kingdom; Chowell, G., Department of Population Health Sciences, School of Public Health, Georgia State University, Atlanta, GA, United States","On 5 February 2020, in Yokohama, Japan, a cruise ship hosting 3,711 people underwent a 2-week quarantine after a former passenger was found with COVID-19 post-disembarking. As at 20 February, 634 persons on board tested positive for the causative virus. We conducted statistical modelling to derive the delay-adjusted asymptomatic proportion of infections, along with the infections' timeline. The estimated asymptomatic proportion was 17.9% (95% credible interval (CrI): 15.5-20.2%). Most infections occurred before the quarantine start.",asymptomatic; corona; COVID-19; Japan; outbreak; quarantine,"COVID-19; severe acute respiratory syndrome coronavirus 2; adolescent; adult; age distribution; aged; asymptomatic infection; Betacoronavirus; child; Coronavirus infection; epidemic; female; genetics; human; infant; isolation and purification; male; middle aged; newborn; preschool child; quarantine; sex ratio; ship; statistical model; travel; very elderly; virus pneumonia; young adult; Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Asymptomatic Infections; Betacoronavirus; Child; Child, Preschool; Coronavirus Infections; Disease Outbreaks; Female; Humans; Infant; Infant, Newborn; Male; Middle Aged; Models, Statistical; Pneumonia, Viral; Quarantine; Sex Distribution; Ships; Travel; Young Adult",,,,NLM (Medline),15607917,,,32183930,English,Euro Surveill.,Article,Final,Open Access,Scopus,2-s2.0-85082063395,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Eurosurveillance Editorial Team,36440437500;,Updated rapid risk assessment from ECDC on the novel coronavirus disease 2019 (COVID-19) pandemic: increased transmission in the EU/EEA and the UK,2020,Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin,25,10,,,,,,10.2807/1560-7917.ES.2020.25.10.2003121,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082048714&doi=10.2807%2f1560-7917.ES.2020.25.10.2003121&partnerID=40&md5=037102987aab736956551835a78136f7,"European Centre for Disease Prevention and Control (ECDC)Stockholm, Sweden","Eurosurveillance Editorial Team, European Centre for Disease Prevention and Control (ECDC)Stockholm, Sweden",[No abstract available],,"COVID-19; Coronavirus infection; Europe; health survey; human; pandemic; public health; risk assessment; social distance; United Kingdom; virus pneumonia; Coronavirus Infections; Europe; Humans; Pandemics; Pneumonia, Viral; Population Surveillance; Public Health; Risk Assessment; Social Distance; United Kingdom",,,,NLM (Medline),15607917,,,32183937,English,Euro Surveill.,Article,Final,Open Access,Scopus,2-s2.0-85082048714,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, [No author name available],[No author id available],Coronavirus: Honorar jetzt extrabudgetär,2020,MMW-Fortschritte der Medizin,162,5,,24,25,,,10.1007/s15006-020-0245-x,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082031963&doi=10.1007%2fs15006-020-0245-x&partnerID=40&md5=81b788568b657e33e9f97bdd97920fa0,,,[No abstract available],,,,,,Springer Medizin,14383276,,MFMEF,32189278,German,MMW-Fortschr. Med.,Note,Final,,Scopus,2-s2.0-85082031963,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Mallapaty S.,55683091500;,How China is planning to go to Mars amid the coronavirus outbreak,2020,Nature,579,7799,,328,329,,,10.1038/d41586-020-00739-5,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081999339&doi=10.1038%2fd41586-020-00739-5&partnerID=40&md5=ee099d4493a3dd617e670a87a10baea8,,"Mallapaty, S.",[No abstract available],Astronomy and astrophysics; Space physics; Virology,,,,,NLM (Medline),14764687,,,32184474,English,Nature,Note,Final,Open Access,Scopus,2-s2.0-85081999339,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Viglione G.,57215112579;,A year without conferences? How the coronavirus pandemic could change research,2020,Nature,579,7799,,327,328,,,10.1038/d41586-020-00786-y,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081993011&doi=10.1038%2fd41586-020-00786-y&partnerID=40&md5=b3c95f0bcc7b1ec5b9d2e356a00eb523,,"Viglione, G.",[No abstract available],Conferences and meetings; Diseases,,,,,NLM (Medline),14764687,,,32184489,English,Nature,Note,Final,Open Access,Scopus,2-s2.0-85081993011,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Burki T.K.,56500213600;,Coronavirus in China,2020,The Lancet. Respiratory medicine,8,3,,238,,,1,10.1016/S2213-2600(20)30056-4,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081945267&doi=10.1016%2fS2213-2600%2820%2930056-4&partnerID=40&md5=a6587fafda4cbcc105da1405af9a42da,,"Burki, T.K.",[No abstract available],,,,,,NLM (Medline),22132619,,,32027848,English,Lancet Respir Med,Article,Final,Open Access,Scopus,2-s2.0-85081945267,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Kirby T.,56957890200;,Australian Government releases face masks to protect against coronavirus,2020,The Lancet. Respiratory medicine,8,3,,239,,,,10.1016/S2213-2600(20)30064-3,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081944287&doi=10.1016%2fS2213-2600%2820%2930064-3&partnerID=40&md5=61f7c77bf37a2d4d73b0efc326d8a454,,"Kirby, T.",[No abstract available],,,,,,NLM (Medline),22132619,,,32043985,English,Lancet Respir Med,Article,Final,Open Access,Scopus,2-s2.0-85081944287,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Abbasi K.,55635858800;,All roads lead to coronavirus,2020,Journal of the Royal Society of Medicine,113,3,,91,,,,10.1177/0141076820911516,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081936435&doi=10.1177%2f0141076820911516&partnerID=40&md5=1d2cceb1de6986fee833435d5d5a8705,,"Abbasi, K.",[No abstract available],,Coronavirus infection; drug cost; funding; human; Note; pandemic; patient worry; public health; vulnerable population,"Ashton, J., The pandemic of coronavirus: tackling the latest plague (2020) J R Soc Med, 113, pp. 123-124; Garattini, L., Padula, A., Pharmaceutical expenditure control in Europe: time to move from pricing to budgeting? (2020) J R Soc Med, 113, pp. 93-97. , and,; Hubbeling, D., Rationing decisions and the endowment effect (2020) J R Soc Med, 113, pp. 98-100; Zhang, J., Sood, H., Harrison, O.T., Horner, B., Sharma, N., Budhdeo, S., Interoperability in NHS hospitals must be improved: the Care Quality Commission should be a key actor in this process (2020) J R Soc Med, 113, pp. 101-104. , and,.,; Bird, W., Adamo, G., Pitini, E., Gray, M., Jani, A., Reducing chronic stress to promote health in adults: the role of social prescriptions and social movements (2020) J R Soc Med, 113, pp. 105-109. , and,.,; Skinner, G.C.M., Farrington, D.P., Shepherd, J.P., Offender trajectories, health and hospital admissions: relationships and risk factors in the longitudinal Cambridge Study in Delinquent Development (2020) J R Soc Med, 113, pp. 110-118. , and,.,; Chalmers, I., Doug Altman's prescience in recognising the need to reduce biases before tackling imprecision in systematic reviews (2020) J R Soc Med, 113, pp. 119-122","Abbasi, K.",,SAGE Publications Ltd,1410768,,JRSMD,32160122,English,J. R. Soc. Med.,Note,Final,Open Access,Scopus,2-s2.0-85081936435,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Ashton J.,57189149739;,The pandemic of coronavirus: tackling the latest plague,2020,Journal of the Royal Society of Medicine,113,3,,123,124,,1,10.1177/0141076820910926,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081906718&doi=10.1177%2f0141076820910926&partnerID=40&md5=0c8cc78dcf63eb944502355e8bfdd7a6,"Independent Public Health Consultant, Liverpool, L25 5JF, United Kingdom","Ashton, J., Independent Public Health Consultant, Liverpool, L25 5JF, United Kingdom",[No abstract available],,Coronavirinae; coronavirus disease 2019; environmental factor; epidemic; food intake; human; infection control; infection risk; national health service; nonhuman; Note; pandemic; plague; poverty; public health; severe acute respiratory syndrome; social life; virus resistance; virus virulence; wildlife; World Health Organization,"Ashton, J., (2019) Practising Public Health – An Eyewitness Account, , Oxford, Oxford University Press","Ashton, J.; Independent Public Health ConsultantUnited Kingdom; email: johnrashton1@icloud.com",,SAGE Publications Ltd,1410768,,JRSMD,32160114,English,J. R. Soc. Med.,Note,Final,Open Access,Scopus,2-s2.0-85081906718,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Spiteri G., Fielding J., Diercke M., Campese C., Enouf V., Gaymard A., Bella A., Sognamiglio P., Sierra Moros M.J., Riutort A.N., Demina Y.V., Mahieu R., Broas M., Bengnér M., Buda S., Schilling J., Filleul L., Lepoutre A., Saura C., Mailles A., Levy-Bruhl D., Coignard B., Bernard-Stoecklin S., Behillil S., van der Werf S., Valette M., Lina B., Riccardo F., Nicastri E., Casas I., Larrauri A., Salom Castell M., Pozo F., Maksyutov R.A., Martin C., Van Ranst M., Bossuyt N., Siira L., Sane J., Tegmark-Wisell K., Palmérus M., Broberg E.K., Beauté J., Jorgensen P., Bundle N., Pereyaslov D., Adlhoch C., Pukkila J., Pebody R., Olsen S., Ciancio B.C.",23474993800;57215774604;37664610800;6602334555;7801666642;57188661052;7004804422;57215773974;7801557324;36898611300;57211322901;57203868475;12788078100;55070912400;7004153382;57215780083;6701741423;6603661127;17736396500;8595630400;16301186700;16023753500;54997917000;35331786800;7005851162;7003960469;7006493939;22956431200;57211086423;55983231900;55947979700;57194489535;56243386000;24559410500;57215770447;7005113740;6506109917;21234330300;35108019500;14033448200;57215775134;6603909215;26323555200;15065224400;57193089832;54966767900;36491191200;57205693931;6603775780;57215776042;24334159400;,"First cases of coronavirus disease 2019 (COVID-19) in the WHO European Region, 24 January to 21 February 2020",2020,Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin,25,9,,,,,,10.2807/1560-7917.ES.2020.25.9.2000178,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081895389&doi=10.2807%2f1560-7917.ES.2020.25.9.2000178&partnerID=40&md5=11671e4546af36021930fbc6594d01fb,"European Centre for Disease Prevention and ControlStockholm, Sweden; World Health Organisation Regional Office for Europe, Copenhagen, Denmark; Robert Koch InstituteBerlin, Germany; Santé Publique France - Direction des maladies infectieuses, France; Centre national de référence Virus des infections respiratoires, Institut Pasteur, Paris, France; Centre national de référence Virus des infections respiratoires, Hospices civils de Lyon, Lyon, France; Istituto Superiore di Sanita, Rome, Italy; Istituto Nazionale Malattie Infettive Lazzaro Spallanzani, Rome, Italy; Coordination Centre for Health Alerts and Emergencies. Spanish Ministry of HealthMadrid, Spain; Servicio de Epidemiología, Dirección General de Salut Pública, Islas Baleares, Spain; Federal Service for Surveillance on Consumer Rights Protection and Human Well-being (Rospotrebnadzor)Moscow, Russian Federation; Department of Infectious Disease Prevention and Control, Common Community Commission, Brussels-Capital Region, Brussels, Belgium; Chief Physician, Infection control unit, Lapland Hospital District, Rovaniemi, Finland; County Medical Officer, Jönköping Region, Sweden; Santé publique France - Direction des régions, Cellule régionale Nouvelle Aquitaine, Bordeaux, France; Santé publique France - Direction des régions, Paris, France; Santé publique France - Direction des régions, Lyon, France; National Centre for Microbiology, WHO-National Influenza Centre, Institute of Health Carlos III. Madrid, Spain; National Centre of Epidemiology, CIBERESP, Institute of Health Carlos III. Madrid, Spain; Dirección General de Salut Pública, Islas Baleares, Spain; State Research Center of Virology and Biotechnology ""Vector"", RospotrebnadzorMoscow, Russian Federation; St. Pierre Hospital, Brussels, Belgium; Laboratory of Clinical Virology, Department of Microbiology and Immunology, Rega Institute, KU Leuven - University of Leuven, Leuven, Belgium; Epidemiology of infectious diseases, Brussels, Belgium; Expert Microbiology Unit, Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland; Infectious Disease Control and Vaccinations Unit, Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland; Public Health Agency of Sweden, Solna, Sweden; Jönköping Region, Sweden; These authors have contributed equally to the manuscript","Spiteri, G., European Centre for Disease Prevention and ControlStockholm, Sweden; Fielding, J., World Health Organisation Regional Office for Europe, Copenhagen, Denmark; Diercke, M., Robert Koch InstituteBerlin, Germany; Campese, C., Santé Publique France - Direction des maladies infectieuses, France; Enouf, V., Centre national de référence Virus des infections respiratoires, Institut Pasteur, Paris, France; Gaymard, A., Centre national de référence Virus des infections respiratoires, Hospices civils de Lyon, Lyon, France; Bella, A., Istituto Superiore di Sanita, Rome, Italy; Sognamiglio, P., Istituto Nazionale Malattie Infettive Lazzaro Spallanzani, Rome, Italy; Sierra Moros, M.J., Coordination Centre for Health Alerts and Emergencies. Spanish Ministry of HealthMadrid, Spain; Riutort, A.N., Servicio de Epidemiología, Dirección General de Salut Pública, Islas Baleares, Spain; Demina, Y.V., Federal Service for Surveillance on Consumer Rights Protection and Human Well-being (Rospotrebnadzor)Moscow, Russian Federation; Mahieu, R., Department of Infectious Disease Prevention and Control, Common Community Commission, Brussels-Capital Region, Brussels, Belgium; Broas, M., Chief Physician, Infection control unit, Lapland Hospital District, Rovaniemi, Finland; Bengnér, M., County Medical Officer, Jönköping Region, Sweden; Buda, S., Robert Koch InstituteBerlin, Germany; Schilling, J., Robert Koch InstituteBerlin, Germany; Filleul, L., Santé publique France - Direction des régions, Cellule régionale Nouvelle Aquitaine, Bordeaux, France; Lepoutre, A., Santé publique France - Direction des régions, Paris, France; Saura, C., Santé publique France - Direction des régions, Lyon, France; Mailles, A., Santé Publique France - Direction des maladies infectieuses, France; Levy-Bruhl, D., Santé Publique France - Direction des maladies infectieuses, France; Coignard, B., Santé Publique France - Direction des maladies infectieuses, France; Bernard-Stoecklin, S., Santé Publique France - Direction des maladies infectieuses, France; Behillil, S., Centre national de référence Virus des infections respiratoires, Institut Pasteur, Paris, France; van der Werf, S., Centre national de référence Virus des infections respiratoires, Institut Pasteur, Paris, France; Valette, M., Centre national de référence Virus des infections respiratoires, Hospices civils de Lyon, Lyon, France; Lina, B., Centre national de référence Virus des infections respiratoires, Hospices civils de Lyon, Lyon, France; Riccardo, F., Istituto Superiore di Sanita, Rome, Italy; Nicastri, E., Istituto Nazionale Malattie Infettive Lazzaro Spallanzani, Rome, Italy; Casas, I., National Centre for Microbiology, WHO-National Influenza Centre, Institute of Health Carlos III. Madrid, Spain; Larrauri, A., National Centre of Epidemiology, CIBERESP, Institute of Health Carlos III. Madrid, Spain; Salom Castell, M., Dirección General de Salut Pública, Islas Baleares, Spain; Pozo, F., National Centre for Microbiology, WHO-National Influenza Centre, Institute of Health Carlos III. Madrid, Spain; Maksyutov, R.A., State Research Center of Virology and Biotechnology ""Vector"", RospotrebnadzorMoscow, Russian Federation; Martin, C., St. Pierre Hospital, Brussels, Belgium; Van Ranst, M., Laboratory of Clinical Virology, Department of Microbiology and Immunology, Rega Institute, KU Leuven - University of Leuven, Leuven, Belgium; Bossuyt, N., Epidemiology of infectious diseases, Brussels, Belgium; Siira, L., Expert Microbiology Unit, Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland; Sane, J., Infectious Disease Control and Vaccinations Unit, Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland; Tegmark-Wisell, K., Public Health Agency of Sweden, Solna, Sweden; Palmérus, M., Jönköping Region, Sweden; Broberg, E.K., European Centre for Disease Prevention and ControlStockholm, Sweden; Beauté, J., European Centre for Disease Prevention and ControlStockholm, Sweden; Jorgensen, P., World Health Organisation Regional Office for Europe, Copenhagen, Denmark; Bundle, N., European Centre for Disease Prevention and ControlStockholm, Sweden; Pereyaslov, D., World Health Organisation Regional Office for Europe, Copenhagen, Denmark; Adlhoch, C., European Centre for Disease Prevention and ControlStockholm, Sweden; Pukkila, J., World Health Organisation Regional Office for Europe, Copenhagen, Denmark; Pebody, R., World Health Organisation Regional Office for Europe, Copenhagen, Denmark; Olsen, S., World Health Organisation Regional Office for Europe, Copenhagen, Denmark, These authors have contributed equally to the manuscript; Ciancio, B.C., European Centre for Disease Prevention and ControlStockholm, Sweden, These authors have contributed equally to the manuscript","In the WHO European Region, COVID-19 surveillance was implemented 27 January 2020. We detail the first European cases. As at 21 February, nine European countries reported 47 cases. Among 38 cases studied, 21 were linked to two clusters in Germany and France, 14 were infected in China. Median case age was 42 years; 25 were male. Late detection of the clusters' index cases delayed isolation of further local cases. As at 5 March, there were 4,250 cases.",coronavirus disease 2019; COVID-19; Novel coronavirus; SARS; SARS-COV-2,"COVID-19; severe acute respiratory syndrome coronavirus 2; virus envelope protein; adolescent; adult; aged; Betacoronavirus; child; China; Coronavirus infection; Europe; female; genetics; health survey; hospitalization; human; isolation and purification; male; middle aged; preschool child; real time polymerase chain reaction; risk factor; travel; very elderly; virus pneumonia; World Health Organization; young adult; Adolescent; Adult; Aged; Aged, 80 and over; Betacoronavirus; Child; Child, Preschool; China; Coronavirus Infections; Europe; Female; Hospitalization; Humans; Male; Middle Aged; Pneumonia, Viral; Population Surveillance; Real-Time Polymerase Chain Reaction; Risk Factors; Travel; Viral Envelope Proteins; World Health Organization; Young Adult",,,,NLM (Medline),15607917,,,32156327,English,Euro Surveill.,Article,Final,Open Access,Scopus,2-s2.0-85081895389,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, [No author name available],[No author id available],"Coronavirus and children, deep-sea microbes and a bold new climate law",2020,Nature,579,7798,,178,179,,,10.1038/d41586-020-00670-9,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081699560&doi=10.1038%2fd41586-020-00670-9&partnerID=40&md5=c2fafe44b5ff123cc321b980d3c12f40,,,[No abstract available],Climate change; Microbiology; Palaeontology; Public health,,,,,NLM (Medline),14764687,,,32161394,English,Nature,Note,Final,Open Access,Scopus,2-s2.0-85081699560,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Anderson P.O.,7404425305;,Breastfeeding and Respiratory Antivirals: Coronavirus and Influenza,2020,Breastfeeding Medicine,15,3,,128,,,,10.1089/bfm.2020.29149.poa,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081694419&doi=10.1089%2fbfm.2020.29149.poa&partnerID=40&md5=24f70997e771cfd164fc7bcc99aec44e,"Division of Clinical Pharmacy, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, San Diego, CA 92093-0657, United States","Anderson, P.O., Division of Clinical Pharmacy, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, San Diego, CA 92093-0657, United States",[No abstract available],,amantadine; antivirus agent; baloxavir; oseltamivir; peramivir; remdesivir; rimantadine; zanamivir; 2019 novel coronavirus; breast feeding; Coronavirinae; Coronavirus infection; human; influenza; influenza A; influenza B; Note; phase 3 clinical trial (topic); priority journal; randomized controlled trial (topic),"Fauci, A., (2020), https://www.pri.org/stories/2020-02-21/controlling-spread-coronavirus-key-stopping-truepandemic-nih-head-says, Interviewed on The World, Public Radio International, February 21; Holshue, M., DeBolt, C., Lindquist, S., First case of 2019 novel coronavirus in the United States (2020) N Engl J Med.; Dornemann, J., Burzio, C., Ronsse, A., First newborn baby to receive experimental therapies survives Ebola virus disease (2017) J Infect Dis., 215, pp. 171-174; Greer, L., Leff, R., Rogers, V., Pharmacokinetics of oseltamivir in breast milk and maternal plasma (2011) Am J Obstet Gynecol., 204, pp. 524e521-524e521; Wentges-Van Holthe, N., Van Eijkeren, M., Van Der Laan, J., Oseltamivir and breastfeeding (2008) Int J Infect Dis., 12, p. 451","Anderson, P.O.; Division of Clinical Pharmacy, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive, United States; email: phanderson@ucsd.edu",,Mary Ann Liebert Inc.,15568253,,,32129667,English,Breastfeeding Med.,Note,Final,Open Access,Scopus,2-s2.0-85081694419,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Chen Q., Allot A., Lu Z.",57215680869;55885227800;57215693424;,Keep up with the latest coronavirus research,2020,Nature,579,7798,,193,,,,10.1038/d41586-020-00694-1,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081693135&doi=10.1038%2fd41586-020-00694-1&partnerID=40&md5=9f0cd5642ee5f16087db97864ff55590,,"Chen, Q.; Allot, A.; Lu, Z.",[No abstract available],Publishing; Research data; Virology,"COVID-19; Coronavirus infection; human; national health organization; publication; research; United States; virology; virus pneumonia; Coronavirus Infections; Humans; National Institutes of Health (U.S.); Periodicals as Topic; Pneumonia, Viral; Research; United States; Virology",,,,NLM (Medline),14764687,,,32157233,English,Nature,Letter,Final,Open Access,Scopus,2-s2.0-85081693135,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Hageman J.R.,7005234813;,The coronavirus disease 2019 (COVID-19),2020,Pediatric Annals,49,3,,e99,e100,,1,10.3928/19382359-20200219-01,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081681087&doi=10.3928%2f19382359-20200219-01&partnerID=40&md5=802f137587a0e3534f902bc1e8c5de34,"The University of Chicago Pritzker School of Medicine, United States; Emeritus Attending Pediatrician, NorthShore University HealthSystem, United States","Hageman, J.R., The University of Chicago Pritzker School of Medicine, United States, Emeritus Attending Pediatrician, NorthShore University HealthSystem, United States",[No abstract available],,"2019 novel coronavirus; coronavirus disease 2019; coughing; Editorial; fever; health care personnel; human; lower respiratory tract infection; practice guideline; public health service; respiratory distress; respiratory syncytial virus infection; screening; travel; adolescent; child; Coronavirus infection; infant; patient isolation; pediatrics; preschool child; protective clothing; virus pneumonia; COVID-19; Adolescent; Child; Child, Preschool; Coronavirus Infections; Humans; Infant; Patient Isolation; Pediatrics; Pneumonia, Viral; Practice Guidelines as Topic; Protective Clothing","As New Cases Surge, Businesses Face Grim Fallout, , https://www.nytimes.com/2020/02/21/world/asia/china-coronavirus.html?te=1&nl=morning-briefing&emc=edit_NN_p_20200221§ion=topNews&campaign_id=9&instance:id=16161&segment_id=21479&user_id=7012abec23da8c7f221b495e52676f4b®i_id=80268415tion=topNews, Accessed February 24, 2020; Lai, R.K.K., Wu, J., McCann, A., Watkins, D., Patel, J.K., Harris, R., Coronavirus Map: Tracking the Spread of the Outbreak, , https://www.nytimes.com/interactive/2020/world/asia/china-wuhan-coronavirus-maps.html?, Accessed February 24, 2020; Coronavirus Disease 2019 (COVID-19) Situation Summary, , https://www.cdc.gov/coronavirus/2019-nCoV/summary.html, Accessed February 19, 2020; (2020) WHO Director-General’s Remarks at the Media Briefing on 2019-Ncov on 11, , https://www.who.int/dg/speeches/detail/who-director-gener-al-s-remarks-at-the-media-briefing-on-2019-n-cov-on-11-february-2020, February, Accessed February 19, 2020; Coronaviruses, including SARS and MERS , , https://redbook.solutions.aap.org/chapter.aspx?sectionid=189640073&bookid=2205, Accessed February 26, 2020; Wu, Z., McGoogan, J.M., Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China. Summary of a report of 72,314 cases from the Chinese Center for Disease Control and Prevention [pub-lished online ahead of print February 24, 2020] JAMA.; Wei, M., Yuan, J., Liu, Y., Novel coronavirus infection in hospitalized infants under 1 year of age in China [published online ahead of print February 14, 2020] JAMA Network; Bartenfeld, M., Griese, S., Uyeki, T., Middle east respiratory syndrome coronavirus and children: What pediatric health professionals need to know (2017) Clin Pediatr, 56 (2), pp. 187-189; Ogimi, C., Englund, J.A., Bradford, M.C., Characteristics and outcomes of coronavirus infection in children: The role of viral factors and in immunocompromised state (2019) J Pediatric Infect Dis Soc, 8 (1), pp. 21-28; Uddin, S.M.I., Englund, J.A., Kuypers, J.Y., Burden and risk factors for coronavirus infections in infants in rural Nepal (2018) Clin Infect Dis, 67 (10), pp. 1507-1514; (2020) Red Book Online. 2019 Novel Coronavirus (CO-VID-19) Infections, , https://redbook.solutions.aap.org/ss/rbo_outbreaks_page_3.aspx; (2020) Novel Coronavirus in China, , https://wwwnc.cdc.gov/travel/notices/alert/novel-coronavirus-china, Accessed February 19; Centers for Disease Control and Prevention (2020) Evaluating and Reporting Persons under Investigation (PUI, , https://www.cdc.gov/coronavirus/2019-nCoV/clinical-criteria.html; Centers for Disease Control and Prevention Interim Infection Prevention and Control Recommendations for Patients with Confirmed 2019 Novel Coronavirus (2019-Ncov) Or Persons under Investigation for 2019-Ncov in Healthcare Settings, , https://www.cdc.gov/coronavirus/2019-nCoV/infection-control.html","Hageman, J.R.; The University of Chicago Pritzker School of MedicineUnited States; email: pedann@Healio.com",,Slack Incorporated,904481,,PDANB,32155273,English,Pediatr. Ann.,Editorial,Final,Open Access,Scopus,2-s2.0-85081681087,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Mallapaty S.,55683091500;,Why does the coronavirus spread so easily between people?,2020,Nature,579,7798,,183,,,,10.1038/d41586-020-00660-x,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081659218&doi=10.1038%2fd41586-020-00660-x&partnerID=40&md5=41d02db065586d6b3fe1d0ad0363dfb0,,"Mallapaty, S.",[No abstract available],Infection; Vaccines,angiotensin converting enzyme 2; dipeptidyl carboxypeptidase; furin; protein binding; viral protein; Coronavirus infection; human; metabolism; virus entry; Coronavirus Infections; Furin; Host Microbial Interactions; Humans; Peptidyl-Dipeptidase A; Protein Binding; Viral Proteins; Virus Internalization,,,,NLM (Medline),14764687,,,32157230,English,Nature,Note,Final,Open Access,Scopus,2-s2.0-85081659218,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Maxmen A.,36867482000;,The race to unravel the biggest coronavirus outbreak in the United States,2020,Nature,579,7798,,181,182,,,10.1038/d41586-020-00676-3,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081643941&doi=10.1038%2fd41586-020-00676-3&partnerID=40&md5=368542225326ab237f6148319eb59c72,,"Maxmen, A.",[No abstract available],Diseases; Public health; Virology,"COVID-19; Coronavirus infection; economics; epidemic; genetics; human; molecular diagnosis; organization; United States; virus genome; virus pneumonia; Academies and Institutes; Coronavirus Infections; Disease Outbreaks; Genome, Viral; Humans; Molecular Diagnostic Techniques; Pneumonia, Viral; United States",,,,NLM (Medline),14764687,,,32152595,English,Nature,Note,Final,Open Access,Scopus,2-s2.0-85081643941,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, [No author name available],[No author id available],"BGI's Coronavirus Response?: Building a Lab in Wuhan, China",2020,Genetic Engineering and Biotechnology News,40,3,,10,11,,,10.1089/gen.40.03.02,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081593958&doi=10.1089%2fgen.40.03.02&partnerID=40&md5=52a8c6642d11c66d71f6004045a3174d,,,[No abstract available],,,,,,Mary Ann Liebert Inc.,1935472X,,,,English,Genet. Eng. Biotechnol. News,Short Survey,Final,Open Access,Scopus,2-s2.0-85081593958,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Callaway E.,23975660600;,Labs rush to study coronavirus in transgenic animals - some are in short supply,2020,Nature,579,7798,,183,,,,10.1038/d41586-020-00698-x,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081593091&doi=10.1038%2fd41586-020-00698-x&partnerID=40&md5=47d1c7059e71e98aba3efbb42550a19b,,"Callaway, E.",[No abstract available],Infection; Virology,"animal; Coronavirus infection; disease model; genetics; Haplorhini; host pathogen interaction; human; mouse; Mustela putorius furo; transgenic animal; virology; Animals; Animals, Genetically Modified; Coronavirus Infections; Disease Models, Animal; Ferrets; Haplorhini; Host Microbial Interactions; Host-Pathogen Interactions; Humans; Mice; Virology",,,,NLM (Medline),14764687,,,32152596,English,Nature,Note,Final,Open Access,Scopus,2-s2.0-85081593091,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Gonçalves-Sá J.,57189024249;,"In the fight against the new coronavirus outbreak, we must also struggle with human bias",2020,Nature Medicine,26,3,,305,,,,10.1038/s41591-020-0802-y,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081540494&doi=10.1038%2fs41591-020-0802-y&partnerID=40&md5=5ed54116bc52a4a4a8e9014f4baf8411,"Nova School of Business and Economics, Carcavelos, Portugal","Gonçalves-Sá, J., Nova School of Business and Economics, Carcavelos, Portugal",[No abstract available],,Coronavirus infection; epidemic; human; misinformation; Note; priority journal,,"Gonçalves-Sá, J.; Nova School of Business and EconomicsPortugal; email: joana.g.sa@novasbe.pt",,Nature Research,10788956,,NAMEF,32152585,English,Nat. Med.,Note,Final,Open Access,Scopus,2-s2.0-85081540494,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Haines A., Anderson S.",57208620172;57215647150;,Why Your Rural Patients May Know More About Coronavirus Than You,2020,South Dakota medicine : the journal of the South Dakota State Medical Association,73,3,,100,101,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081529510&partnerID=40&md5=e647ff5acdb11290d5b4c18f87c56d4d,University of South Dakota Sanford School of Medicine,"Haines, A., University of South Dakota Sanford School of Medicine; Anderson, S.",[No abstract available],,,,,,NLM (Medline),383317,,,32142226,English,S D Med,Editorial,Final,,Scopus,2-s2.0-85081529510,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Nkengasong J.,7005111716;,"Author Correction: China’s response to a novel coronavirus stands in stark contrast to the 2002 SARS outbreak response (Nature Medicine, (2020), 26, 3, (310-311), 10.1038/s41591-020-0771-1)",2020,Nature Medicine,26,3,,441,,,,10.1038/s41591-020-0816-5,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081329209&doi=10.1038%2fs41591-020-0816-5&partnerID=40&md5=70a54139c69cdcc3b3a4c44a021b0802,"Africa Centres for Disease Control and Prevention, Addis Ababa, Ethiopia","Nkengasong, J., Africa Centres for Disease Control and Prevention, Addis Ababa, Ethiopia","In the version of this article initially published, the date (year) was incorrect (10 January 2010) in the penultimate sentence of the first paragraph of the third subsection (‘Why Africa should be prepared’). The correct date is 10 January 2020. The error has been corrected in the HTML and PDF versions of the article. © 2020, Springer Nature America, Inc.",,erratum,,"Nkengasong, J.; Africa Centres for Disease Control and PreventionEthiopia; email: nkengasongj@africa-union.org",,Nature Research,10788956,,NAMEF,32139890,English,Nat. Med.,Erratum,Final,Open Access,Scopus,2-s2.0-85081329209,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Poon L.L.M., Peiris M.",7005441747;7005486823;,Emergence of a novel human coronavirus threatening human health,2020,Nature Medicine,26,3,,317,319,,1,10.1038/s41591-020-0796-5,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081301501&doi=10.1038%2fs41591-020-0796-5&partnerID=40&md5=848a879b9dca9cece8a5795d4f001aa7,"School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong","Poon, L.L.M., School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong; Peiris, M., School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong",[No abstract available],,virus RNA; 2009 H1N1 influenza; antibody response; artificial ventilation; Betacoronavirus; China; common cold; Coronavirus disease 2019; Coronavirus infection; coughing; disease severity; dyspnea; epidemic; fever; global health; human; intermediate host; myalgia; nonhuman; Note; oxygen therapy; pneumonia; priority journal; public health; rhinorrhea; SARS coronavirus; Severe acute respiratory syndrome coronavirus 2; sore throat,"Corman, V.M., (2016) Proc. Natl Acad. Sci. USA, 113, pp. 9864-9869. , COI: 1:CAS:528:DC%2BC28XhtlChsLnN; Zhu, N., (2020) N. Engl. J. Med., 382, pp. 727-733. , COI: 1:CAS:528:DC%2BB3cXjslGmsrc%3D; Lu, R., (2020) Lancet, 395, pp. 565-574; Zhou, P., (2020), https://doi.org/10.1101/2020.01.22.914952; Li, Q., (2020) N. Engl. J. Med.; Tian, X., (2020) Emerg. Microbes Infect., 9, pp. 382-385; Wan, Y., Shang, J., Graham, R., Baric, R.S., Li, F.J., (2020) Virol, , https://doi.org/10.1128/JVI.00127-20; Chen, N., (2020) Lancet, 395, pp. 507-513. , COI: 1:CAS:528:DC%2BB3cXhvFOmsb8%3D; Chan, J.F.-W., (2020) Lancet, 395, pp. 514-523. , COI: 1:CAS:528:DC%2BB3cXhs1Ojsro%3D; Rothe, C., (2020) N. Engl. J. Med, , https://doi.org/10.1056/NEJMc2001468; Holshue, M.L., (2020) N. Engl. J. Med, , https://doi.org/10.1056/NEJMoa2001191; Huang, C., (2020) Lancet, 395, pp. 497-506. , COI: 1:CAS:528:DC%2BB3cXhs1Kqu7c%3D; Wu, J.T., Leung, K., Leung, G.M., (2020) Lancet, , https://doi.org/10.1016/S0140-6736(20)30260-9; Wong, J.Y., (2013) Epidemiology, 24, pp. 830-841; Choe, P.G., (2017) Emerg. Infect. Dis., 23, pp. 1079-1084. , COI: 1:CAS:528:DC%2BC1cXhvFGjt7nI","Peiris, M.; School of Public Health, LKS Faculty of Medicine, The University of Hong KongHong Kong; email: malik@hku.hk",,Nature Research,10788956,,NAMEF,32108160,English,Nat. Med.,Note,Final,Open Access,Scopus,2-s2.0-85081301501,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Wiffen P.,7003381761;,Houston we have a problem: Coronavirus!,2020,European Journal of Hospital Pharmacy ,27,2,,59,,,,10.1136/ejhpharm-2020-002240,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081233114&doi=10.1136%2fejhpharm-2020-002240&partnerID=40&md5=9d27f2df9b24c7521a71e83aa49088ae,"Pain Research Unit, Churchill Hospital, Oxford, OX3 7LE, United Kingdom","Wiffen, P., Pain Research Unit, Churchill Hospital, Oxford, OX3 7LE, United Kingdom",[No abstract available],accident & emergency medicine; audit; basic sciences; intensive & critical care; pain management,confusion; Coronavirinae; coughing; diarrhea; dyspnea; Editorial; fatigue; fever; global health; headache; hemoptysis; human; myalgia; nausea; nonhuman; rhinorrhea; risk factor; SARS coronavirus; sore throat; space flight; sputum; thorax pain; virus pneumonia; virus transmission,"Phelan, A.L., Katz, R., Gostin, L.O., The novel coronavirus originating in Wuhan, China: Challenges for global health governance (2020) JAMA, , [Epub ahead of print: 30 Jan 2020]; (2020) BMJ, , https://bestpractice.bmj.com/topics/engb/3000165?q=Coronavirus,%202019%20novel&c=suggested, [Accessed Feb]; (2020) The BMJ, , bmj.com/coronavirus, Coronavirus. [Accessed Feb]","Wiffen, P.; Pain Research Unit, Churchill HospitalUnited Kingdom; email: pwiffen@oxfordsrs.org.uk",,BMJ Publishing Group,20479956,,,,English,Euro. J. Hosp. Pharm. Sci. Pra.,Editorial,Final,Open Access,Scopus,2-s2.0-85081233114,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, [No author name available],[No author id available],Neuartiges Coronavirus (SARS-CoV-2),2020,Deutsche Medizinische Wochenschrift,145,5,,336,337,,,10.1055/a-1113-3096,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081212233&doi=10.1055%2fa-1113-3096&partnerID=40&md5=1b4a4ba417d53c5d5751e8c59bf756d9,,,[No abstract available],,,"Holshue, M., Debolt, C., Lindquist, S., First Case of 2019 Novel Coronavirus in the United States (2020) N Engl J Med",,,Georg Thieme Verlag,120472,,DMWOA,,German,Dtsch. Med. Wochenschr.,Note,Final,Open Access,Scopus,2-s2.0-85081212233,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Sookaromdee P., Wiwanitkit V.",57189377276;55628572491;,Imported cases of 2019-novel coronavirus (2019-nCoV) infections in Thailand: Mathematical modelling of the outbreak,2020,Asian Pacific Journal of Tropical Medicine,13,3,,139,140,,2,10.4103/1995-7645.277516,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081150961&doi=10.4103%2f1995-7645.277516&partnerID=40&md5=9d3b4afa2891a773b4e3767a1b927113,"TWS Medical Center, Bangkok, Thailand; Department of Community Medicine, Dr DY Patil University, Pune, India; Hainan Medical University, Haikou, China; Chulalongkorn University, Bangkok, Thailand","Sookaromdee, P., TWS Medical Center, Bangkok, Thailand; Wiwanitkit, V., Department of Community Medicine, Dr DY Patil University, Pune, India, Hainan Medical University, Haikou, China, Chulalongkorn University, Bangkok, Thailand",[No abstract available],,2019 novel coronavirus infection; acceleration; Coronavirinae; Coronavirus infection; disease control; disease duration; epidemic; human; Letter; managed care; mathematical model; priority journal; professional knowledge; public health; Thailand; treatment planning; virus transmission,"Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., A Novel coronavirus from patients with pneumonia in China, 2019 N Engl J Med, , 2020 Jan 24; Hsia, W., Emerging new coronavirus infection in Wuhan, China: Situation in early 2020 (2020) Case Study Case Rep, 10 (1), pp. 8-9; Wu, J.T., Leung, K., Leung, G.M., Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: A modelling study (2020) Lancet January 31; Yasri, S., Wiwanitkit, V., Editorial: Wuhan coronavirus outbreak and imported case (2020) Adv Trop Med Pub Health Int, 10 (1), pp. 1-2","Sookaromdee, P.; TWS Medical CenterThailand; email: pathumsook@gmail.com",,Wolters Kluwer Medknow Publications,19957645,,,,English,Asian Pac. J. Trop. Med.,Letter,Final,,Scopus,2-s2.0-85081150961,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Yasri S., Wiwanitkit V.",56022182600;55628572491;,Dose prediction of lopinavir/ritonavir for 2019-novel coronavirus (2019-nCoV) infection based on mathematic modeling,2020,Asian Pacific Journal of Tropical Medicine,13,3,,137,138,,1,10.4103/1995-7645.277815,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081148400&doi=10.4103%2f1995-7645.277815&partnerID=40&md5=daf7a2113862693ee63dff1c80a609b4,"KMT Primary Care Center, Bangkok, Thailand; Department of Community Medicine, Dr DY Patil University, Pune, India; Hainan Medical University, Haikou, China; Chulalongkorn University, Bangkok, Thailand","Yasri, S., KMT Primary Care Center, Bangkok, Thailand; Wiwanitkit, V., Department of Community Medicine, Dr DY Patil University, Pune, India, Hainan Medical University, Haikou, China, Chulalongkorn University, Bangkok, Thailand",[No abstract available],,lopinavir plus ritonavir; proteinase; virus enzyme; 2019 novel coronavirus; antiviral therapy; calculation; comparative study; Coronavirinae; Coronavirus infection; enzyme activity; human; Human immunodeficiency virus infection; Letter; mathematical model; molecular weight; nonhuman; prediction; priority journal,"Hsia, W., Emerging new coronavirus infection in Wuhan, China: Situation in early 2020 (2020) Case Study Case Rep, 10, pp. 8-9; Yasri, S., Wiwanitkit, V., Editorial: Wuhan coronavirus outbreak and imported case (2019) Adv Trop Med Pub Health Int, 9, pp. 1-2; Sookaromdee, P., Wiwanikit, V., Imported cases of 2019-novel coronavirus (2019-nCoV) infection in Thailand: Mathematical modelling of the ourtbreak (2020) Asian Pac J Trop Med, 13 (3); Lu, H., Drug treatment options for the 2019-new coronavirus (2019-nCoV) (2020) Biosci Trends; Stothard, P., The sequence manipulation suite: JavaScript programs for analyzing and formatting protein and DNA sequences (2000) Bio Techniques, 28 (6), pp. 1102-1104; Wiwanitkit, S., Wiwanitkit, V., Doubled dosage of sofosbuvir is expected for inhibiting Zika virus infection (2017) Asian Pac J Trop Med, 10 (6), pp. 612-613","Yasri, S.; KMT Primary Care CenterThailand; email: sorayasri@outlook.co.th",,Wolters Kluwer Medknow Publications,19957645,,,,English,Asian Pac. J. Trop. Med.,Letter,Final,,Scopus,2-s2.0-85081148400,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Fasina F.,16416667800;,Novel coronavirus (2019-nCoV) update: What we know and what is unknown,2020,Asian Pacific Journal of Tropical Medicine,13,3,,97,98,,,10.4103/1995-7645.277795,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081146254&doi=10.4103%2f1995-7645.277795&partnerID=40&md5=ac6b5e64cee5167bf0a9d37dae4a2863,"Emergency Centre for Transboundary Animal Diseases, Food and Agriculture Organization of the United Nations (FAO-ECTAD), Dar es Salaam, 14111, Tanzania; Department of Veterinary Tropical Diseases, University of Pretoria, Onderstepoort, 0110, South Africa","Fasina, F., Emergency Centre for Transboundary Animal Diseases, Food and Agriculture Organization of the United Nations (FAO-ECTAD), Dar es Salaam, 14111, Tanzania, Department of Veterinary Tropical Diseases, University of Pretoria, Onderstepoort, 0110, South Africa",[No abstract available],,2019 novel Coronavirus; avian influenza (H5N1); cardiovascular disease; chronic liver disease; chronic obstructive lung disease; clinical feature; comorbidity; consultation; Coronavirinae; Coronavirus infection; coughing; diabetes mellitus; diarrhea; dyspnea; Editorial; fever; headache; hemoptysis; human; hypertension; infection risk; intermediate host; international health regulation; Middle East respiratory syndrome; Middle East respiratory syndrome coronavirus; myalgia; nonhuman; priority journal; SARS coronavirus; virus transmission; World Health Organization,"https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports/.[assessedon4February2020], World Health Organization (WHO). Novel coronavirus (2019-nCoV) situation reports, 2020; Wang, C., Horby, P.W., Hayden, F.G., Gao, G.F., A novel coronavirus outbreak of global health concern (2020) Lancet; Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., A Novel coronavirus from patients with pneumonia in China, 2019 (2020) New Engl J Med; Hui, D.S., Azhar, E.I., Madani, T.A., Ntoumi, F., Kock, R., Dar, O., The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health-The latest 2019 novel coronavirus outbreak in Wuhan, China (2020) J Infect Dis, 91, pp. 264-266; Heymann, D.L., Data sharing and outbreaks: Best practice exemplified (2020) Lancet; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet; Chan, J.F.W., Yuan, S., Kok, K.H., To, K.K.W., Chu, H., Yang, J., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: A study of a family cluster (2020) Lancet; Corman, V., Bleicker, T., Brünink, S., Drosten, C., Landt, O., Koopmans, M., (2019) By Real-time RT-PCR: Protocol and Preliminary Evaluation As of January 13, 2020, , https://www.who.int/docs/default-source/coronaviruse/wuhan-virus-assay-v1991527e5122341d99287a1b17c111902.pdf?sfvrsn=d381fc88_2, Diagnostic detection of Wuhan coronavirus, 2020. [accessed on 4 February 2020] ; Lu, R., Zhao, X., Li, J., Niu, P., Yang, B., Wu, H., Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding (2020) Lancet; Imai, N., Dorigatti, I., Cori, A., Donnelly, C.A., Riley, S., Ferguson, N.M., Report 2: Estimating the Potential Total Number of Novel Coronavirus Cases in Wuhan City, China, 2020a, , https://www.imperial.ac.uk/media/imperial-college/medicine/sph/ide/gida-fellowships/2019-nCoV-outbreak-report-22-01-2020.pdf; Imai, N., Cori, A., Dorigatti, I., Baguelin, M., Donnelly, C.A., Riley, S., Report 3: Transmissibility of 2019-nCoV, 2020b, , https://www.imperial.ac.uk/media/imperial-college/medicine/sph/ide/gida-fellowships/Imperial-2019-nCoV-transmissibility.pdf, [accessed on 4 February 2020] . [accessed on 4 February 2020]; Rothe, C., Schunk, M., Sothmann, P., Bretzel, G., Froeschl, G., Wallrauch, C., Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany (2020) New Engl J Med","Fasina, F.; Emergency Centre for Transboundary Animal Diseases, Food and Agriculture Organization of the United Nations (FAO-ECTAD)Tanzania; email: Folorunso.Fasina@fao.org",,Wolters Kluwer Medknow Publications,19957645,,,,English,Asian Pac. J. Trop. Med.,Editorial,Final,,Scopus,2-s2.0-85081146254,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Burki T.,56500213600;,Outbreak of coronavirus disease 2019,2020,The Lancet. Infectious diseases,20,3,,292,293,,,10.1016/S1473-3099(20)30076-1,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081073725&doi=10.1016%2fS1473-3099%2820%2930076-1&partnerID=40&md5=3b43135e70ab4793fc8aff2644e9f0ee,,"Burki, T.",[No abstract available],,,,,,NLM (Medline),14744457,,,32078809,English,Lancet Infect Dis,Article,Final,Open Access,Scopus,2-s2.0-85081073725,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, [No author name available],[No author id available],"Coronavirus nixes conference, twilight zone beckons and a faded star brightens",2020,Nature,579,7797,,12,13,,,10.1038/d41586-020-00589-1,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081043386&doi=10.1038%2fd41586-020-00589-1&partnerID=40&md5=ebe78e571e3b8b134c3a67264e8d21b8,,,[No abstract available],Astronomy and astrophysics; Genetics; Ocean sciences; Public health,,,,,NLM (Medline),14764687,,,32132700,English,Nature,Note,Final,Open Access,Scopus,2-s2.0-85081043386,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Cyranoski D.,57208765775;,Mystery deepens over animal source of coronavirus,2020,Nature,579,7797,,18,19,,2,10.1038/d41586-020-00548-w,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081042747&doi=10.1038%2fd41586-020-00548-w&partnerID=40&md5=ffc214570bbb55d5bbaf912ebc7c3b87,,"Cyranoski, D.",[No abstract available],Animal behaviour; Public health; Zoology,"COVID-19; animal; bat; Coronavirinae; Coronavirus infection; genetics; human; isolation and purification; placental mammal; reproducibility; uncertainty; virology; virus pneumonia; zoonosis; Animals; Chiroptera; Coronavirus; Coronavirus Infections; Eutheria; Humans; Pneumonia, Viral; Reproducibility of Results; Uncertainty; Zoonoses",,,,NLM (Medline),14764687,,,32127703,English,Nature,Note,Final,Open Access,Scopus,2-s2.0-85081042747,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Moorthy V., Restrepo A.M.H., Preziosi M.-P., Swaminathan S.",57191861075;56448296500;6701408578;57212555825;,Data sharing for novel coronavirus (COVID-19),2020,Bulletin of the World Health Organization,98,3,,150,,,,10.2471/BLT.20.251561,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081020956&doi=10.2471%2fBLT.20.251561&partnerID=40&md5=1c1ae52e083f1d6e79badfc65a493549,"Science Division, World Health Organization, Avenue Appia 20, Geneva 27, 1211, Switzerland; Health Emergencies Preparedness and Response, World Health Organization, Geneva, Switzerland; Universal Health Coverage/Life Course, World Health Organization, Geneva, Switzerland","Moorthy, V., Science Division, World Health Organization, Avenue Appia 20, Geneva 27, 1211, Switzerland; Restrepo, A.M.H., Health Emergencies Preparedness and Response, World Health Organization, Geneva, Switzerland; Preziosi, M.-P., Universal Health Coverage/Life Course, World Health Organization, Geneva, Switzerland; Swaminathan, S., Science Division, World Health Organization, Avenue Appia 20, Geneva 27, 1211, Switzerland",[No abstract available],,2019 novel coronavirus; coronavirus disease 2019; disease carrier; disease control; disease transmission; Editorial; human; information processing; peer review; public health; publication; World Health Organization; Betacoronavirus; Coronavirus infection; information dissemination; Coronavirus; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; Coronavirus Infections; Humans; Information Dissemination,"Dye, C., Bartolomeos, K., Moorthy, V., Kieny, M.P., Data sharing in public health emergencies: A call to researchers (2016) Bull World Health Organ, 94 (3). , doi: http://dx.doi. org/; Modjarrad, K., Moorthy, V.S., Millett, P., Gsell, P.-S., Roth, C., Kieny, M.-P., Developing global norms for sharing data and results during public health emergencies (2016) Plos Med, 13 (1), p. e1001935. , doi: http://dx.doi. org/; Whitty, C.J.M., Mundel, T., Farrar, J., Heymann, D.L., Davies, S.C., Walport, M.J., Providing incentives to share data early in health emergencies: The role of journal editors (2015) Lancet, 386 (10006), pp. 1797-1798. , 7, doi: http://dx.doi. org; Recommendations for the conduct, reporting, editing, and publication of scholarly work in medical journals Philadelphia: International Committee of Medical Journal Editors, 2020. , http://www.icmje.org/recommendations/browse/publishing-and-editorial-issues/overlapping-publications.html, Available from, cited 2020 Jan 24; (2020) International Society for Infectious Diseases, , http://www.promedmail.org/, Northampton: Brookline, Available from:, [cited 2020 Jan 27]; (2020), https://f1000research.com/, London: F1000 Research, Available from, [cited 2020 Jan 27]","Moorthy, V.; Science Division, World Health Organization, Avenue Appia 20, Switzerland; email: moorthyv@who.int",,World Health Organization,429686,,BWHOA,32132744,English,Bull. WHO,Editorial,Final,Open Access,Scopus,2-s2.0-85081020956,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhu Y., Chen L., Ji H., Xi M., Fang Y., Li Y.",57190050217;57215536309;57205202219;55324136200;8571442200;57192522527;,The Risk and Prevention of Novel Coronavirus Pneumonia Infections Among Inpatients in Psychiatric Hospitals,2020,Neuroscience Bulletin,36,3,,299,302,,1,10.1007/s12264-020-00476-9,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081001439&doi=10.1007%2fs12264-020-00476-9&partnerID=40&md5=2a73094f8245ce164c3fbff102f7bdfc,"Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China; Shanghai Changning Mental Health Center (Affiliated to East China Normal University), Shanghai, 200335, China; Institute of Burns, Tongren Hospital of Wuhan University (Wuhan Third Hospital), Wuhan, 430000, China; Affiliated Wuhan Mental Health Center, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, 430012, China; CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai, 200031, China; Shanghai Key Laboratory of Psychotic Disorders, Shanghai, 201108, China","Zhu, Y., Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China; Chen, L., Shanghai Changning Mental Health Center (Affiliated to East China Normal University), Shanghai, 200335, China; Ji, H., Shanghai Changning Mental Health Center (Affiliated to East China Normal University), Shanghai, 200335, China; Xi, M., Institute of Burns, Tongren Hospital of Wuhan University (Wuhan Third Hospital), Wuhan, 430000, China; Fang, Y., Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai, 200031, China, Shanghai Key Laboratory of Psychotic Disorders, Shanghai, 201108, China; Li, Y., Affiliated Wuhan Mental Health Center, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, 430012, China",[No abstract available],,"COVID-19; coping behavior; Coronavirus infection; epidemic; hospital patient; human; mental hospital; risk factor; virus pneumonia; Adaptation, Psychological; Coronavirus Infections; Disease Outbreaks; Hospitals, Psychiatric; Humans; Inpatients; Pneumonia, Viral; Risk Factors","Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med; Cui, Y., Zhang, Z.F., Froines, J., Zhao, J., Wang, H., Yu, S.Z., Air pollution and case fatality of SARS in the People’s Republic of China: an ecologic study (2003) Environ Health, 2, pp. 2-15; Chan-Yeung, M., (2003) Xu RH. SARS: epidemiology. Respirology, 8, pp. 1440-1843; Chang, Lin, M., Wei, L., Xie, L., Zhu, G., Dela Cruz, C.S., Epidemiologic and clinical characteristics of novel coronavirus infections involving 13 patients outside Wuhan, China (2020) JAMA; Lobo-Escolar, A., Saz, P., Marcos, G., Quintanilla, M.A., Campayo, A., Lobo, A., Somatic and psychiatric comorbidity in the general elderly population: results from the ZARADEMP project (2008) J Psychosom Res, 65, pp. 347-355; Lee, A.M., Wong, J.G., McAlonan, G.M., Cheung, V., Cheung, C., Sham, P.C., Stress and psychological distress among SARS survivors 1 year after the outbreak (2007) Can J Psychiatry, 52, pp. 233-240; Enserink, M., Researcher told to stay home after China trip (2003) Science, 300, p. 1216. , COI: 1:CAS:528:DC%2BD3sXltF2qs7k%3D; Xiang, Y.T., Yang, Y., Li, W., Zhang, L., Zhang, Q., Cheung, T., Timely mental health care for the 2019 novel coronavirus outbreak is urgently needed (2020) Lancet Psychiatry, 4, pp. 30046-30048; Kang, L., Li, Y., Hu, S., Chen, M., Yang, C., Yang, B.X., Wang, Y., Liu, Z., The mental health of medical workers in Wuhan, China dealing with the 2019 novel coronavirus (2020) The Lancet Psychiatry, 7 (3); Ma, N., Ma, H., Li, L.J., Reading and analysis of the guiding principles of emergent psychological crisis intervention in the novel coronavirusd pneumonia (2020) Chin J Psychiatry, 53, p. E001","Fang, Y.; Shanghai Mental Health Center, Shanghai Jiao Tong University School of MedicineChina; email: yirufang@aliyun.com",,Springer,16737067,,,32096116,English,Neurosci. Bull.,Letter,Final,Open Access,Scopus,2-s2.0-85081001439,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Malta M., Rimoin A.W., Strathdee S.A.",8118265500;9744662700;57216065152;,The coronavirus 2019-nCoV epidemic: Is hindsight 20/20?,2020,EClinicalMedicine,20,,100289,,,,,10.1016/j.eclinm.2020.100289,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080894822&doi=10.1016%2fj.eclinm.2020.100289&partnerID=40&md5=27b5c48752555c70168757ceaf30bb03,"Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Social Science, National School of Public Health, Oswaldo Cruz Foundation (DCS-ENSP/FIOCRUZ), Rio de Janeiro, Brazil; Department of Epidemiology, Jonathan and Karin Fielding School of Public Health, University of California, Los Angeles, United States; Department of Medicine, University of California San Diego School of Medicine, La Jolla, CA, United States","Malta, M., Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, ON, Canada, Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, ON, Canada, Department of Social Science, National School of Public Health, Oswaldo Cruz Foundation (DCS-ENSP/FIOCRUZ), Rio de Janeiro, Brazil; Rimoin, A.W., Department of Epidemiology, Jonathan and Karin Fielding School of Public Health, University of California, Los Angeles, United States; Strathdee, S.A., Department of Medicine, University of California San Diego School of Medicine, La Jolla, CA, United States",[No abstract available],,China; coronavirus disease 2010; Coronavirus infection; disease severity; epidemic; geographic distribution; government regulation; health care policy; health service; human; infection control; infection rate; Middle East respiratory syndrome; Note; pandemic; travel; virus transmission; Zika fever,"Wu, J.T., Leung, K., Leung, G.M., Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study (2020) Lancet, , Published online ahead of print; Ji, W., Wang, W., Zhao, X., Zai, J., Li, X., Cross-species transmission of the newly identified coronavirus 2019-nCoV (2020) J Med Virol, 92, pp. 433-440; Lo, M.Y., Ngan, W.Y., Tsun, S.M., Hsing, H.L., Lau, K.T., Hung, H.P., A field study into Hong Kong's wet markets: raised questions into the hygienic maintenance of meat contact surfaces and the dissemination of microorganisms associated with nosocomial infections (2019) Front Microbiol, 10, p. 2618; Huang, Y., The SARS epidemic and its aftermath in China: a political perspective (2004) Learning from SARS: preparing for the next disease outbreak: workshop summary, , https://www.ncbi.nlm.nih.gov/books/NBK92479/, S. Knobler A. Mahmoud S. Lemon et al. (eds.) National Academies Press (US) WashingtonDC Institute of Medicine (US) Forum on Microbial Threats Available from:; https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports/, World Health Organization. Novel coronavirus(2019-ncov): situation reports. Available from:; Lowe, R., Barcellos, C., Brasil, P., Cruz, O.G., Honorio, N.A., Kuper, H., Carvalho, M.S., The zika virus epidemic in Brazil: from discovery to future implications (2018) Int J Environ Res Public Health, 15 (1), p. 96; Alexander, K.A., Sanderson, C.E., Marathe, M., Lewis, B.L., Rivers, C.M., Shaman, J., What factors might have led to the emergence of Ebola in West Africa? (2015) PLoS Negl Trop Dis., 9; Munster, V.J., Koopmans, M., van Doremalen, N., van Riel, D., de Wit, E., A novel coronavirus emerging in China—key questions for impact assessment (2020) N Engl J Med., 10. , [Published online ahead of print; https://www.cbsnews.com/live-updates/coronavirus-outbreak-china-evacuations-wuhan-death-toll-today-flights-us-cases-2020-01-31/, CBS News. “U.S. health officials issue quarantine order for 195 Americans evacuated from China” Available from:","Malta, M.; Department of Psychiatry, Faculty of Medicine, University of TorontoCanada; email: monica.malta@utoronto.ca",,Lancet Publishing Group,25895370,,,,English,EClinicalMedicine,Note,Final,Open Access,Scopus,2-s2.0-85080894822,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Ling C.-Q.,55567948900;,Traditional Chinese medicine is a resource for drug discovery against 2019 novel coronavirus (SARS-CoV-2),2020,Journal of Integrative Medicine,18,2,,87,88,,,10.1016/j.joim.2020.02.004,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080104164&doi=10.1016%2fj.joim.2020.02.004&partnerID=40&md5=ff00f1f4d15c9b8176408295d386a143,"School of Traditional Chinese Medicine, Naval Medical University, Shanghai, 200433, China","Ling, C.-Q., School of Traditional Chinese Medicine, Naval Medical University, Shanghai, 200433, China",[No abstract available],,antivirus agent; herbaceous agent; natural product; severe acute respiratory syndrome vaccine; Chinese medicine; computer model; coronavirus disease 2019; Coronavirus infection; Editorial; epidemic; inflammation; Middle East respiratory syndrome coronavirus; priority journal; reliability; SARS coronavirus; screening; severe acute respiratory syndrome coronavirus 2; virus pneumonia,"Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 24; Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med, 29; Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2019) JAMA, 2020, p. 7; Holshue, M.L., DeBolt, C., Lindquist, S., Lofy, K.H., Wiesman, J., Bruce, H., First case of 2019 novel coronavirus in the United States (2019) N Engl J Med, 2020, p. 31; Patel, A., Jernigan, D.B., 2019-nCoV CDC Response Team, Initial public health response and interim clinical guidance for the 2019 novel coronavirus outbreak—United States, December 31, 2019–February 4, 2020 (2020) MMWR Morb Mortal Wkly Rep, 69 (5), pp. 140-146; World Health Organization, (2004), http://apps.who.int/medicinedocs/en/d/Js6170e, SARS: Clinical trials on treatment using a combination of traditional Chinese medicine and Western medicine. [2020-02-08]; Wu, A., Peng, Y., Huang, B., Ding, X., Wang, X., Niu, P., Genome composition and divergence of the novel coronavirus (2019-nCoV) originating in China (2020) Cell Host Microbe, , pii: S1931-3128(20)30072-X. doi: 10.1016/j.chom.2020.02.001; Zhang, D.H., Wu, K.L., Zhang, X., Deng, S.Q., Peng, B., In silico screening of Chinese herbal medicines with the potential to directly inhibit 2019 novel coronavirus (2020) J Integr Med, 18 (2), pp. 152-158; http://www.tcmspw.com/browse.php?qc=herbs, Lab of Systems Pharmacology. TCMSP: Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform. (2013-11) [2020-02-08]; Shaikh, F., Zhao, Y., Alvarez, L., Iliopoulou, M., Lohans, C., Schofield, C.J., Structure-based in silico screening identifies a potent ebolavirus inhibitor from a traditional Chinese medicine library (2019) J Med Chem, 62 (6), pp. 2928-2937",,,Elsevier (Singapore) Pte Ltd,20954964,,,32122812,English,J. Integr. Med.,Editorial,Final,Open Access,Scopus,2-s2.0-85080104164,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Ronco C., Navalesi P., Vincent J.L.",57207869845;6701562087;7403122266;,Coronavirus epidemic: preparing for extracorporeal organ support in intensive care,2020,The Lancet Respiratory Medicine,8,3,,240,241,,2,10.1016/S2213-2600(20)30060-6,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080096056&doi=10.1016%2fS2213-2600%2820%2930060-6&partnerID=40&md5=7e81110ef3a1c4289c07d2128e7132cf,"Department of Medicine, University of Padua, Padua, Italy; International Renal Research Institute, Vicenza, Italy; Division of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, Vicenza, Italy; Anesthesia and Intensive Care Unit, Padua University Hospital, Padua, Italy; Department of Intensive Care, Erasme University Hospital, Bruxelles, Belgium","Ronco, C., Department of Medicine, University of Padua, Padua, Italy, International Renal Research Institute, Vicenza, Italy, Division of Nephrology, Dialysis and Transplantation, San Bortolo Hospital, Vicenza, Italy; Navalesi, P., Department of Medicine, University of Padua, Padua, Italy, International Renal Research Institute, Vicenza, Italy, Anesthesia and Intensive Care Unit, Padua University Hospital, Padua, Italy; Vincent, J.L., Department of Intensive Care, Erasme University Hospital, Bruxelles, Belgium",[No abstract available],,cytokine; 2019 novel coronavirus; acute heart failure; acute respiratory failure; adult respiratory distress syndrome; aerosol; aging; Article; artificial ventilation; basic reproduction number; camel; cell regeneration; China; comorbidity; continuous hemodiafiltration; continuous hemofiltration; Coronavirinae; critically ill patient; disease course; disease severity; disease transmission; dyspnea; electron microscopy; emergency care; epidemic; Europe; extracorporeal circulation; extracorporeal oxygenation; extracorporeal therapy; health care delivery; health care personnel; heart function; hemadsorption; hemoperfusion; hospital admission; human; immune response; immune status; infection prevention; infection risk; inflammation; intensive care; intensive care unit; kidney function; liver cell; liver dysfunction; Middle East respiratory syndrome; multiple organ failure; pathophysiology; patient compliance; patient monitoring; prescription; priority journal; public health service; renal replacement therapy; Saudi Arabia; sea food; sequence analysis; severe acute respiratory syndrome; social marketing; treatment outcome; United States; virus identification; virus myocarditis,,,,Lancet Publishing Group,22132600,,,32035509,English,Lancet Respir. Med.,Article,Final,Open Access,Scopus,2-s2.0-85080096056,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhang J., Zhou L., Yang Y., Peng W., Wang W., Chen X.",23973753700;56518530300;57196011558;57215188958;57215191841;57215192005;,Therapeutic and triage strategies for 2019 novel coronavirus disease in fever clinics,2020,The Lancet Respiratory Medicine,8,3,,e11,e12,,3,10.1016/S2213-2600(20)30071-0,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080095327&doi=10.1016%2fS2213-2600%2820%2930071-0&partnerID=40&md5=0bccbd1b4277cef53b31f7c3f0bc4e88,"Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Department of Gerontology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; First Affiliated Hospital of Guangzhou Medical University, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, Guangzhou, China; Division of ICU and Respiratory Service, Department of Internal Medicine, Salt Lake Regional Medical Center, Heart and Lung Institute of Utah, Salt Lake City, UT, United States","Zhang, J., Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Zhou, L., First Affiliated Hospital of Guangzhou Medical University, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, Guangzhou, China; Yang, Y., First Affiliated Hospital of Guangzhou Medical University, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, Guangzhou, China; Peng, W., Division of ICU and Respiratory Service, Department of Internal Medicine, Salt Lake Regional Medical Center, Heart and Lung Institute of Utah, Salt Lake City, UT, United States; Wang, W., Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Chen, X., Department of Gerontology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China",[No abstract available],,amoxicillin; antivirus agent; arbidol; azithromycin; C reactive protein; dexamethasone; levofloxacin; linezolid; methylprednisolone; moxifloxacin; nemonoxacin; oxygen; severe acute respiratory syndrome coronavirus 2; 2019 novel coronavirus; anesthesiological procedure; antiviral therapy; blood cell count; body temperature measurement; China; clinical decision making; community acquired pneumonia; consultation; Coronavirinae; differential diagnosis; drug megadose; dyspnea; emergency health service; epidemic; fever; general practitioner; ground glass opacity; health care personnel; home care; hospital admission; hospital care; hospital discharge; host resistance; human; hypoxemia; hypoxia; immunocompromised patient; immunopathology; in vitro study; influenza; Letter; life threat; lung lesion; lymphocyte count; lymphocytopenia; methicillin resistant Staphylococcus aureus infection; Middle East respiratory syndrome; mixed infection; obstetrician; oxygen saturation; patient isolation; pneumococcal infection; pneumonia; positive end expiratory pressure; practice guideline; pregnancy termination; pregnant woman; prescription; priority journal; public health; respiratory syncytial virus infection; SARS coronavirus; SARS coronavirus 2; severe acute respiratory syndrome; Staphylococcus aureus; Staphylococcus aureus infection; Streptococcus pneumoniae; therapy effect; thorax radiography; virus pneumonia; Betacoronavirus; Coronavirus infection; emergency health service; Betacoronavirus; China; Coronavirus; Coronavirus Infections; Humans; Triage,"Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, , published online Jan 24.; Khamitov, R.A., Loginova, S., Shchukina, V.N., Borisevich, S.V., Maksimov, V.A., Shuster, A.M., Antiviral activity of arbidol and its derivatives against the pathogen of severe acute respiratory syndrome in the cell cultures (2008) Vopr Virusol, 53, pp. 9-13; Hageman, J.C., Uyeki, T.M., Francis, J.S., Severe community-acquired pneumonia due to Staphylococcus aureus, 2003–04 influenza season (2006) Emerg Infect Dis, 12, pp. 894-899; Chen, R.C., Tang, X.P., Tan, S.Y., Treatment of severe acute respiratory syndrome with glucosteroids: the Guangzhou experience (2006) Chest, 129, pp. 1441-1452; WHO, Home care for patients with suspected novel coronavirus (nCoV) infection presenting with mild symptoms and management of contacts https://www.who.int/publications-detail/home-care-for-patients-with-suspected-novel-coronavirus-(ncov)-infection-presenting-with-mild-symptoms-and-management-of-contacts, (Accessed 7 February 2020)",,,Lancet Publishing Group,22132600,,,32061335,English,Lancet Respir. Med.,Letter,Final,Open Access,Scopus,2-s2.0-85080095327,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Chang D., Xu H., Rebaza A., Sharma L., Dela Cruz C.S.",57212582518;57215186152;56958498300;55349407200;6602433042;,Protecting health-care workers from subclinical coronavirus infection,2020,The Lancet Respiratory Medicine,8,3,,e13,,,9,10.1016/S2213-2600(20)30066-7,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080067515&doi=10.1016%2fS2213-2600%2820%2930066-7&partnerID=40&md5=1e904411f004c054dc5e97a7d45b14fb,"Department of Respiratory Medicine, Third Medical Center of Chinese PLA General Hospital, Beijing, China; Section of Pulmonary and Critical Care and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, CT 06520, United States; Section of Pediatric Pulmonary, Allergy, Immunology and Sleep Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, United States; Institute for Medical Device Standardization Administration, National Institute for Food and Drug Control, Beijing, China","Chang, D., Department of Respiratory Medicine, Third Medical Center of Chinese PLA General Hospital, Beijing, China, Section of Pulmonary and Critical Care and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, CT 06520, United States; Xu, H., Institute for Medical Device Standardization Administration, National Institute for Food and Drug Control, Beijing, China; Rebaza, A., Section of Pediatric Pulmonary, Allergy, Immunology and Sleep Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, United States; Sharma, L., Section of Pulmonary and Critical Care and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, CT 06520, United States; Dela Cruz, C.S., Section of Pulmonary and Critical Care and Sleep Medicine, Department of Medicine, Yale University School of Medicine, New Haven, CT 06520, United States",[No abstract available],,acute disease; China; clinical effectiveness; coronavirus disease 2019; Coronavirus infection; coughing; epidemic; fever; health care personnel; human; Letter; nonhuman; occupational hazard; practice guideline; priority journal; severe acute respiratory syndrome; symptom; virus pneumonia; virus transmission,"Chan, J.F.-W., Yuan, S., Kok, K.-H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, , published online Jan 24; Announcement of national health commision of the people's republic of China (2020), http://wwwnhcgovcn/jkj/s7916/202001/44a3b8245e8049d2837a4f27529cd386shtml, (Accessed 6 February 2020); WHO, Novel coronavirus (2019-nCoV) situation report—2 (2020), https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200122-sitrep-2-2019-ncov.pdf, (Accessed 6 February 2020); Yan, A., Chinese expert who came down with Wuhan coronavirus after saying it was controllable thinks he was infected through his eyes. South China Morning Post (2020), https://www.scmp.com/news/china/article/3047394/chinese-expert-who-came-down-wuhan-coronavirus-after-saying-it-was, (Accessed 6 February 2020); Rothe, C., Schunk, M., Sothmann, P., Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany (2020) N Engl J Med, , published online Jan 30. DOI:",,,Lancet Publishing Group,22132600,,,32061333,English,Lancet Respir. Med.,Letter,Final,Open Access,Scopus,2-s2.0-85080067515,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Ward M.P., Li X., Tian K.",57205475522;57215096012;25631167800;,"Novel coronavirus 2019, an emerging public health emergency",2020,Transboundary and Emerging Diseases,67,2,,469,470,,,10.1111/tbed.13509,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079896211&doi=10.1111%2ftbed.13509&partnerID=40&md5=716fcacb7ed49bf4498e0e7a989eeb54,"Sydney School of Veterinary Science, The University of Sydney, Camden, NSW, Australia; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou, China; College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, China; National Research Center for Veterinary Medicine, Luoyang, China","Ward, M.P., Sydney School of Veterinary Science, The University of Sydney, Camden, NSW, Australia; Li, X., Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, College of Veterinary Medicine, Yangzhou University, Yangzhou, China; Tian, K., College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, China, National Research Center for Veterinary Medicine, Luoyang, China",[No abstract available],,2019 novel coronavirus; Alphacoronavirus; Betacoronavirus; China; climate change; coronavirus disease 2019; disease transmission; dyspnea; Editorial; fever; Gammacoronavirus; geographic distribution; headache; human; lung lesion; Middle East respiratory syndrome; public health; severe acute respiratory syndrome; thorax radiography; urbanization; virus isolation; World Health Organization; zoonosis,"Chen, Y., Liu, Q., Guo, D., Coronaviruses: Genome structure, replication, and pathogenesis (2020) Journal of Medical Virology, , https://doi.org/10.1002/jmv.25681; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Cao, B., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) The Lancet, 395, pp. 497-506. , https://doi.org/10.1016/S0140-6736(20)30183-5; Ji, W., Wang, W., Zhao, X.F., Zai, J.J., Li, X.G., Homologous recombination within the spike glycoprotein of the newly identified coronavirus 2019-nCoV may boost cross-species transmission from snake to human (2020) Journal of Medical Virology, , https://doi.org/10.1002/jmv.25682; Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Feng, Z., Early transmission dynamics in Wuhan, china, of novel coronavirus-infected pneumonia (2020) New England Journal of Medicine, , https://doi.org/10.1056/NEJMoa2001316; Wang, C., Horby, P.W., Hayden, F.G., Gao, G.F., A novel coronavirus outbreak of global health concern (2020) The Lancet, 395, pp. 470-473. , https://doi.org/10.1016/S0140-6736(20)30185-9; Wu, J.T., Leung, K., Leung, G.M., Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: A modelling study (2020) The Lancet, 395, pp. 470-473. , https://doi.org/10.1016/S0140-6736(20)30260-9; Xu, X., Chen, P., Wang, J., Feng, J., Zhou, H., Li, X., Hao, P., Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission (2020) Science China Life Sciences, 63. , https://doi.org/10.1007/s11427-020-1637-5","Ward, M.P.; Sydney School of Veterinary Science, The University of SydneyAustralia; email: michael.ward@sydney.edu.au",,Blackwell Publishing Ltd,18651674,,,32077206,English,Transboundary Emer. Dis.,Editorial,Final,Open Access,Scopus,2-s2.0-85079896211,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Bastola A., Sah R., Rodriguez-Morales A.J., Lal B.K., Jha R., Ojha H.C., Shrestha B., Chu D.K.W., Poon L.L.M., Costello A., Morita K., Pandey B.D.",56204036000;57195544674;8886801000;57195329823;57214136920;57215082208;57215091939;7201734326;7005441747;36505770400;7403261262;7102018582;,The first 2019 novel coronavirus case in Nepal,2020,The Lancet Infectious Diseases,20,3,,279,280,,7,10.1016/S1473-3099(20)30067-0,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079891488&doi=10.1016%2fS1473-3099%2820%2930067-0&partnerID=40&md5=387f84f461ef442e0db107d5405f7a23,"Sukraraj Tropical and Infectious Disease Hospital, Kathmandu, Nepal; National Public Health Laboratory, Kathmandu, 44600, Nepal; Global Health and Sustainable Development, University College London, London, United Kingdom; Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnologica de Pereira, Pereira, Risaralda, Colombia; Epidemiology and Disease Control Division, Government of Nepal, Kathmandu, Nepal; School of Public Health, LKS Faculty of Medicine, The University of Hong KongHong Kong Special Administrative Region, China; Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan","Bastola, A., Sukraraj Tropical and Infectious Disease Hospital, Kathmandu, Nepal; Sah, R., National Public Health Laboratory, Kathmandu, 44600, Nepal; Rodriguez-Morales, A.J., Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnologica de Pereira, Pereira, Risaralda, Colombia; Lal, B.K., Epidemiology and Disease Control Division, Government of Nepal, Kathmandu, Nepal; Jha, R., National Public Health Laboratory, Kathmandu, 44600, Nepal; Ojha, H.C., Epidemiology and Disease Control Division, Government of Nepal, Kathmandu, Nepal; Shrestha, B., Sukraraj Tropical and Infectious Disease Hospital, Kathmandu, Nepal; Chu, D.K.W., School of Public Health, LKS Faculty of Medicine, The University of Hong KongHong Kong Special Administrative Region, China; Poon, L.L.M., School of Public Health, LKS Faculty of Medicine, The University of Hong KongHong Kong Special Administrative Region, China; Costello, A., Global Health and Sustainable Development, University College London, London, United Kingdom; Morita, K., Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan; Pandey, B.D., Sukraraj Tropical and Infectious Disease Hospital, Kathmandu, Nepal",[No abstract available],,antibiotic agent; 2019 novel coronavirus; adult; case report; clinical article; Coronavirinae; Coronavirus infection; coughing; crackle; dyspnea; follow up; hospital admission; human; informed consent; Letter; lung infiltrate; male; Nepalese; oxygen saturation; priority journal; real time reverse transcription polymerase chain reaction; thorax radiography; throat culture,"Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, , published online Jan 24; Chan, J.F.-W., Yuan, S., Kok, K.-H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, , published online Jan 24; Statement on the second meeting of the International Health Regulations (2005) Emergency Committee regarding the outbreak of novel coronavirus (2019-nCoV) (2020), https://www.who.int/news-room/detail/30-01-2020-statement-on-the-second-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-outbreak-of-novel-coronavirus-(2019-ncov), (Accessed 2 January 2020); Novel coronavirus (2019-nCoV)—Situation report—10–30 January (2020), https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200130-sitrep-10-ncov.pdf?sfvrsn=d0b2e480_2, (Accessed 2 January 2020); Phan, L.T., Nguyen, T.V., Luong, Q.C., Importation and human-to-human transmission of a novel coronavirus in Vietnam (2020) N Engl J Med, , published online Jan 28; Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, , published online Jan 24; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wçuhan, China: a descriptive study (2020) Lancet, , published online Jan 30; Rothe, C., Schunk, M., Sothmann, P., Transmission of 2019-ncov infection from an asymptomatic contact in Germany (2020) N Engl J Med, , published Jan 30",,,Lancet Publishing Group,14733099,,LIDAB,32057299,English,Lancet Infect. Dis.,Letter,Final,Open Access,Scopus,2-s2.0-85079891488,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, The Lancet Infectious Diseases,55922722600;,Challenges of coronavirus disease 2019,2020,The Lancet Infectious Diseases,20,3,,261,,,1,10.1016/S1473-3099(20)30072-4,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079889190&doi=10.1016%2fS1473-3099%2820%2930072-4&partnerID=40&md5=b5c1aa9872c6eb57fbe26000325a98b4,,The Lancet Infectious Diseases,[No abstract available],,,,,,Lancet Publishing Group,14733099,,LIDAB,32078810,English,Lancet Infect. Dis.,Editorial,Final,Open Access,Scopus,2-s2.0-85079889190,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Li J., Li J.J., Xie X., Cai X., Huang J., Tian X., Zhu H.",57215098018;57215098021;57215097615;57215084498;57215092267;57215621942;55717907300;,Game consumption and the 2019 novel coronavirus,2020,The Lancet Infectious Diseases,20,3,,275,276,,4,10.1016/S1473-3099(20)30063-3,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079883412&doi=10.1016%2fS1473-3099%2820%2930063-3&partnerID=40&md5=bd1f8b0477908c055f411f7ec9f2bd39,"School of Geographical Sciences, Guangzhou University, Guangzhou 510006, Guangdong, China; College of Resources and Environmental Science, Ningxia University, Yinchuan, Ningxia, China; School of Tourism Management, South China Normal University, Guangzhou, Guangdong, China; School of Life Science, South China Normal University, Guangzhou, Guangdong, China; Division of Geography and Tourism, Department of Earth and Environmental Sciences, Katholieke Universiteit Leuven, Leuven, Belgium","Li, J., School of Geographical Sciences, Guangzhou University, Guangzhou 510006, Guangdong, China, College of Resources and Environmental Science, Ningxia University, Yinchuan, Ningxia, China; Li, J.J., School of Tourism Management, South China Normal University, Guangzhou, Guangdong, China; Xie, X., Division of Geography and Tourism, Department of Earth and Environmental Sciences, Katholieke Universiteit Leuven, Leuven, Belgium; Cai, X., School of Tourism Management, South China Normal University, Guangzhou, Guangdong, China; Huang, J., School of Geographical Sciences, Guangzhou University, Guangzhou 510006, Guangdong, China; Tian, X., School of Life Science, South China Normal University, Guangzhou, Guangdong, China; Zhu, H., School of Geographical Sciences, Guangzhou University, Guangzhou 510006, Guangdong, China",[No abstract available],,aphrodisiac agent; 2019 novel coronavirus; brain; circulation; Coronavirinae; Coronavirus infection; disease severity; Ebola hemorrhagic fever; epidemic; fish; food intake; game animal; genotype; Haplorhini; human; internet access; kidney; law; liver disease; meat; microbial diversity; Middle East respiratory syndrome coronavirus; modern times; neurologic disease; Note; penis; Pholidota (animal); pneumonia; prehistoric period; priority journal; public health; respiratory tract disease; rheumatic disease; RNA virus; SARS coronavirus; sea food; severe acute respiratory syndrome; social marketing; therapy effect; tiger; wild animal; zoonosis,"Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, , published online Jan 24; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, , published online Jan 24; Chan, J.F.-W., Yuan, S., Kok, K.-H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, , published online Jan 24; Update on pneumonia caused by the new coronavirus infections http://www.nhc.gov.cn/xcs/yqtb/list_gzbd.shtml, (Accessed 4 February 2020); Zaki, A.M., van Boheemen, S., Bestebroer, T.M., Osterhaus, A.D.M.E., Fouchier, R.A.M., Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia (2012) N Engl J Med, 367, pp. 1814-1820; McIntosh, K., Coronaviruses: a comparative review (1974) Curr Top Microbiol Immunol, 63, pp. 85-129; Peiris, J.S.M., Yuen, K.Y., Osterhaus, A.D.M.E., Stöhr, K., The severe acute respiratory syndrome (2003) N Engl J Med, 349, pp. 2431-2441; Azhar, E.I., El-Kafrawy, S.A., Farraj, S.A., Evidence for camel-to-human transmission of MERS coronavirus (2014) N Engl J Med, 370, pp. 2499-2505; Webster, R.G., Wet markets—a continuing source of severe acute respiratory syndrome and influenza? (2004) Lancet, 363, pp. 234-236; Zhou, P., Yang, X.-L., Wang, X.-G., Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin (2020) bioRxiv, , published online Jan 23. (preprint)",,,Lancet Publishing Group,14733099,,LIDAB,32043979,English,Lancet Infect. Dis.,Note,Final,Open Access,Scopus,2-s2.0-85079883412,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Colson P., Rolain J.-M., Raoult D.",7102090499;6701695724;57208853524;,Chloroquine for the 2019 novel coronavirus SARS-CoV-2,2020,International Journal of Antimicrobial Agents,55,3,105923,,,,7,10.1016/j.ijantimicag.2020.105923,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079880333&doi=10.1016%2fj.ijantimicag.2020.105923&partnerID=40&md5=006b04747f6da9984216a6e4819a4461,"Aix-Marseille Université, Institut de Recherche pour le Développement (IRD), Assistance Publique–Hôpitaux de Marseille (AP-HM), MEPHI, 27 boulevard Jean Moulin, Marseille, 13005, France; IHU Méditerranée Infection, 19–21 boulevard Jean Moulin, Marseille, 13005, France","Colson, P., Aix-Marseille Université, Institut de Recherche pour le Développement (IRD), Assistance Publique–Hôpitaux de Marseille (AP-HM), MEPHI, 27 boulevard Jean Moulin, Marseille, 13005, France, IHU Méditerranée Infection, 19–21 boulevard Jean Moulin, Marseille, 13005, France; Rolain, J.-M., Aix-Marseille Université, Institut de Recherche pour le Développement (IRD), Assistance Publique–Hôpitaux de Marseille (AP-HM), MEPHI, 27 boulevard Jean Moulin, Marseille, 13005, France, IHU Méditerranée Infection, 19–21 boulevard Jean Moulin, Marseille, 13005, France; Raoult, D., Aix-Marseille Université, Institut de Recherche pour le Développement (IRD), Assistance Publique–Hôpitaux de Marseille (AP-HM), MEPHI, 27 boulevard Jean Moulin, Marseille, 13005, France, IHU Méditerranée Infection, 19–21 boulevard Jean Moulin, Marseille, 13005, France",[No abstract available],,chloroquine; hydroxychloroquine; remdesivir; teicoplanin; chloroquine; severe acute respiratory syndrome coronavirus 2; antiviral activity; China; Coronavirus disease 2019; coronavirus disease 2019; Coronavirus infection; drug efficacy; drug repositioning; drug safety; EC50; Editorial; in vitro study; nonhuman; phagolysosome; priority journal; SARS coronavirus; severe acute respiratory syndrome; severe acute respiratory syndrome 2; severe acute respiratory syndrome coronavirus 2; virus inhibition; virus isolation; virus replication; animal; bat; Betacoronavirus; Coronavirinae; epidemic; pneumonia; Animals; Betacoronavirus; Chiroptera; Chloroquine; Coronavirus; Disease Outbreaks; Pneumonia; SARS Virus,"Mullard, A., Drug repurposing programmes get lift off (2012) Nat Rev Drug Discov, 11, pp. 505-506; Zhou, P., Yang, X.L., Wang, X.G., Hu, B., Zhang, L., Zhang, W., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature, , [Epub ahead of print]; Savarino, A., Di Trani, L., Donatelli, I., Cauda, R., Cassone, A., New insights into the antiviral effects of chloroquine (2006) Lancet Infect Dis, 6, pp. 67-69; Rolain, J.M., Colson, P., Raoult, D., Recycling of chloroquine and its hydroxyl analogue to face bacterial, fungal and viral infections in the 21st century (2007) Int J Antimicrob Agents, 30, pp. 297-308; Vincent, M.J., Bergeron, E., Benjannet, S., Erickson, B.R., Rollin, P.E., Ksiazek, T.G., Chloroquine is a potent inhibitor of SARS coronavirus infection and spread (2005) Virol J, 2, p. 69; Ksiazek, T.G., Erdman, D., Goldsmith, C.S., Zaki, S.R., Peret, T., Emery, S., A novel coronavirus associated with severe acute respiratory syndrome (2003) N Engl J Med, 348, pp. 1953-1966; Balzarini, J., Keyaerts, E., Vijgen, L., Egberink, H., De Clercq, E., Van Ranst, M., Inhibition of feline (FIPV) and human (SARS) coronavirus by semisynthetic derivatives of glycopeptide antibiotics (2006) Antiviral Res, 72, pp. 20-33; Keyaerts, E., Vijgen, L., Maes, P., Neyts, J., Van Ranst, M., In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine (2004) Biochem Biophys Res Commun, 323, pp. 264-268; Barnard, D.L., Day, C.W., Bailey, K., Heiner, M., Montgomery, R., Lauridsen, L., Evaluation of immunomodulators, interferons and known in vitro SARS-coV inhibitors for inhibition of SARS-coV replication in BALB/c mice (2006) Antivir Chem Chemother, 17, pp. 275-284; de Wilde, A.H., Jochmans, D., Posthuma, C.C., Zevenhoven-Dobbe, J.C., van Nieuwkoop, S., Bestebroer, T.M., Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture (2014) Antimicrob Agents Chemother, 58, pp. 4875-4884; Yu, I.T., Qiu, H., Tse, L.A., Wong, T.W., Severe acute respiratory syndrome beyond Amoy Gardens: completing the incomplete legacy (2014) Clin Infect Dis, 58, pp. 683-686; Wang, M., Cao, R., Zhang, L., Yang, X., Liu, J., Xu, M., Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro (2020) Cell Res, , [Epub ahead of print]; Agostini, M.L., Andres, E.L., Sims, A.C., Graham, R.L., Sheahan, T.P., Lu, X., Coronavirus susceptibility to the antiviral remdesivir (GS-5734) is mediated by the viral polymerase and the proofreading exoribonuclease (2018) mBio, 9. , pii: e00221-18; White, N.J., Pukrittayakamee, S., Hien, T.T., Faiz, M.A., Mokuolu, O.A., Dondorp, A.M., Malaria (2014) Lancet, 383, pp. 723-735; Al-Bari, M.A., Chloroquine analogues in drug discovery: new directions of uses, mechanisms of actions and toxic manifestations from malaria to multifarious diseases (2015) J Antimicrob Chemother, 70, pp. 1608-1621; Lee, S.J., Silverman, E., Bargman, J.M., The role of antimalarial agents in the treatment of SLE and lupus nephritis (2011) Nat Rev Nephrol, 7, pp. 718-729","Raoult, D.; IHU Méditerranée Infection, 19–21 boulevard Jean Moulin, France; email: didier.raoult@gmail.com",,Elsevier B.V.,9248579,,IAAGE,32070753,English,Int. J. Antimicrob. Agents,Editorial,Final,Open Access,Scopus,2-s2.0-85079880333,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Lee K.S.,56561307600;,Pneumonia associated with 2019 novel coronavirus: Can computed tomographic findings help predict the prognosis of the disease?,2020,Korean Journal of Radiology,21,3,,257,258,,,10.3348/kjr.2020.0096,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079861948&doi=10.3348%2fkjr.2020.0096&partnerID=40&md5=a864c67442a6aa9aa8992687685c9fd0,"Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea","Lee, K.S., Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea",[No abstract available],,2019 novel coronavirus; antibiotic therapy; bronchopneumonia; clinical outcome; computer assisted tomography; Coronavirinae; Coronavirus infection; differential diagnosis; disease exacerbation; Editorial; follow up; ground glass opacity; human; immunocompetence; influenza A; lung injury; lung nodule; lung ventilation; Middle East respiratory syndrome; nonhuman; organizing pneumonia; patient care; pleura effusion; pneumonia; prognosis; radiological parameters; severe acute respiratory syndrome; treatment response; virus pneumonia,"Lin, X., Gong, Z., Xiao, Z., Xiong, J., Fan, B., Liu, J., Novel coronavirus pneumonia outbreak in 2019: Computed tomographic findings in two cases (2020) Korean J Radiol, , https://doi.org/10.3348/kjr.2020.0078; Chung, M., Bernheim, A., Mei, X., Zhang, N., Huang, M., Zeng, X., CT imaging features of 2019 Novel Coronavirus (2019-nCoV) (2020) Radiology, , https://doi.org/10.1148/radiol.2020200230, Feb 4 [Epub]; Kim, E.A., Lee, K.S., Primack, S.L., Yoon, H.K., Byun, H.S., Kim, T.S., Viral pneumonias in adults: Radiologic and pathologic finidings (2002) Radiographics, pp. S137-S149. , Spec No; Wong, K.T., Antonio, G.E., Hui, D.S., Lee, N., Yuen, E.H., Wu, A., Thin-section CT of severe acute respiratory syndrome: Evaluation of 73 patients exposed to or with the disease (2003) Radiology, 228, pp. 395-400; Ajlan, A.M., Ahyad, R.A., Jamjoom, L.G., Alharthy, A., Mandani, T.A., Middle East respiratory syndrome coronavirus (MERS-CoV) infection: Chest CT findings (2014) AJR am J Roentgenol, 203, pp. 782-787; Choi, W.J., Lee, K.N., Kang, E.J., Lee, H., Middle East respiratory syndrome-coronavirus infection: A case report of serial computed tomographic findings in a young male patient (2016) Korean J Radiol, 17, pp. 166-170; Lee, K.S., Kim, T.J., Peck, K.R., Han, J., Infectious pneumonia in immunocompetent patients: Updates in clinical and imaging features (2018) Precis Future Med, 2, pp. 79-94; Kang, H., Lee, K.S., Jeong, Y.J., Lee, H.Y., Kim, K.I., Nam, K.J., Computed tomography findings of influenza A (H1N1) pneumonia in adults: Pattern analysis and prognostic comparisons (2012) J Comut Assit Tomogr, 36, pp. 285-290; Das, K.M., Lee, E.Y., Enani, M.A., Aljawder, S.E., Singh, R., Bashir, S., CT correlation with outcomes in 15 patients with acute Middle East respiratory syndrome coronavirus (2015) AJR am J Roentgenol, 204, pp. 736-742","Lee, K.S.; Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, South Korea; email: kyungs.lee@samsung.com",,Korean Radiological Society,12296929,,,32056396,English,Korean J. Radiol.,Editorial,Final,,Scopus,2-s2.0-85079861948,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Khan S., Ali A., Siddique R., Nabi G.",57192387486;57213370320;57192396029;57189842203;,Novel coronavirus is putting the whole world on alert,2020,Journal of Hospital Infection,104,3,,252,253,,2,10.1016/j.jhin.2020.01.019,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079837095&doi=10.1016%2fj.jhin.2020.01.019&partnerID=40&md5=ba2db49c1e6695c1bca3810bb74ee7b1,"Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Henan Medical Key Laboratory of Translational Cerebrovascular Diseases, Zhengzhou, China; Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China; University of Chinese Academy of Sciences, Beijing, China; Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei Province, College of Life Sciences, Hebei Normal University, Shijiazhuang, China","Khan, S., Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China, Henan Medical Key Laboratory of Translational Cerebrovascular Diseases, Zhengzhou, China; Ali, A., Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China, University of Chinese Academy of Sciences, Beijing, China; Siddique, R., Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China, Henan Medical Key Laboratory of Translational Cerebrovascular Diseases, Zhengzhou, China; Nabi, G., Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology of Hebei Province, College of Life Sciences, Hebei Normal University, Shijiazhuang, China",[No abstract available],,adult respiratory distress syndrome; alertness; China; coronavirus disease 2019; Coronavirus infection; disease course; epidemic; health care planning; human; infection control; infection prevention; mass screening; Note; pandemic; pneumonia; quarantine; Betacoronavirus; Coronavirinae; Coronavirus infection; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; China; Coronavirus; Coronavirus Infections; Humans,"Zhong, N.S., Zheng, B.J., Li, Y.M., Poon, Xie, Z.H., Chan, K.H., Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China, in February, 2003 (2003) Lancet, 362, p. 1353; Bawazir, A., Al-Mazroo, E., Jradi, H., Ahmed, A., Badri, M., MERS-CoV infection: mind the public knowledge gap (2018) J Infect Public Health, 11, pp. 89-93; Editorial, Stop the Wuhan coronavirus (2020) Nature, 577, p. 450; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 20, pp. 30183-30185. , pii: S0140-6736; Regan, H., George, S., Renton, A., US CDC warns against all nonessential travel to China over coronavirus (2020), https://edition.cnn.com/asia/live-news/coronavirus-outbreak-01-28-20-intl-hnk/index.html, CNN Available at: [last accessed January 2020]; Five million people left Wuhan before the lockdown, where did they go? CGTV https://news.cgtn.com/news/2020-01-27/5-million-people-left-Wuhan-before-the-lockdown-where-did-they-go, Available at: [last accessed January 2020]; Zhou, L., Elmer, K., China coronavirus: thousands left Wuhan for Hong Kong, Bangkok, Singapore or Tokyo before lockdown (2020), https://www.scmp.com/news/china/society/article/3047805/coronavirus-thousands-left-wuhan-hong-kong-bangkok-singapore-or, South China Morning Post Available at: [last accessed January 2020]; Samuel, H., Wuhan woman ‘cheated’ coronavirus checks to fly out for Michelin-starred meal in France (2020), https://www.telegraph.co.uk/news/2020/01/24/ire-chinese-woman-cheated-coronavirus-checks-fly-france-michelin/, The Telegraph Available at: [last accessed January 2020]","Khan, S.; Department of Cerebrovascular Diseases, Second Affiliated Hospital of Zhengzhou UniversityChina; email: Suliman.khan18@mails.ucas.ac.cn",,W.B. Saunders Ltd,1956701,,JHIND,32032614,English,J. Hosp. Infect.,Note,Final,Open Access,Scopus,2-s2.0-85079837095,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Patel A., Jernigan D.B., Abdirizak F., Abedi G., Aggarwal S., Albina D., Allen E., Andersen L., Anderson J., Anderson M., Anderson T., Anderson K., Bardossy A.C., Barry V., Beer K., Bell M., Berger S., Bertulfo J., Biggs H., Bornemann J., Bornstein J., Bower W., Bresee J., Brown C., Budd A., Buigut J., Burke S., Burke R., Burns E., Butler J., Cantrell R., Cardemil C., Cates J., Cetron M., Chatham-Stephens K., Chatham-Stevens K., Chea N., Christensen B., Chu V., Clarke K., Cleveland A., Cohen N., Cohen M., Cohn A., Collins J., Conners E., Curns A., Dahl R., Daley W., Dasari V., Davlantes E., Dawson P., Delaney L., Donahue M., Dowell C., Dyal J., Edens W., Eidex R., Epstein L., Evans M., Fagan R., Farris K., Feldstein L., Fox L., Frank M., Freeman B., Fry A., Fuller J., Galang R., Gerber S., Gokhale R., Goldstein S., Gorman S., Gregg W., Greim W., Grube S., Hall A., Haynes A., Hill S., Hornsby-Myers J., Hunter J., Ionta C., Isenhour C., Jacobs M., Jacobs Slifka K., Jernigan D., Jhung M., Jones-Wormley J., Kambhampati A., Kamili S., Kennedy P., Kent C., Killerby M., Kim L., Kirking H., Koonin L., Koppaka R., Kosmos C., Kuhar D., Kuhnert-Tallman W., Kujawski S., Kumar A., Landon A., Lee L., Leung J., Lindstrom S., Link-Gelles R., Lively J., Lu X., Lynch B., Malapati L., Mandel S., Manns B., Marano N., Marlow M., Marston B., McClung N., McClure L., McDonald E., McGovern O., Messonnier N., Midgley C., Moulia D., Murray J., Noelte K., Noonan-Smith M., Nordlund K., Norton E., Oliver S., Pallansch M., Parashar U., Patel A., Patel M., Pettrone K., Pierce T., Pietz H., Pillai S., Radonovich L., Reagan-Steiner S., Reel A., Reese H., Rha B., Ricks P., Rolfes M., Roohi S., Roper L., Rotz L., Routh J., Sakthivel S.K., Sarmiento L., Schindelar J., Schneider E., Schuchat A., Scott S., Shetty V., Shockey C., Shugart J., Stenger M., Stuckey M., Sunshine B., Sykes T., Uyeki T., Vahey G., Valderrama A., Villanueva J., Walker T., Wallace M., Wang L., Watson J., Weber A., Weinbaum C., Weldon W., Westnedge C., Whitaker B., Whitaker M., Williams A., Willams I., Wong K., Xie A., Yousef A., 2019-nCoV CDC Response Team",57216130526;7006094592;56816947600;55887217800;57216132313;57216127704;57216123067;57216124068;55497549600;57216135087;57215141503;57216124450;57216123470;57216125200;57216131369;57216123367;57216123362;57216127066;46460986500;57216123905;57216128660;57216128043;7003805082;57216132433;22833854100;57216132206;57216127046;57216130730;36551022300;7403924852;57216129284;57216133657;57216126719;56278989600;24328792200;57216135222;36196157100;57193204636;57215780607;57215124554;57216131338;25959939100;57216131625;57215533230;57216124756;57216123380;6603608087;56160038100;57216129921;57215778011;57188584757;57216126942;57211538186;57209103804;57216132672;57216132970;57216126080;57216135360;57216132366;57215118708;57216132744;57216124013;56395375400;57215533530;57216141551;57216127642;13407240200;57216123552;56685415000;56656063700;57150611200;57216127008;57194476837;38461178600;57216127098;57216127645;57215807024;57216125540;57204366672;7801477932;55988616700;57216130512;57215134010;57215770482;55775202200;57216052638;13612187900;57216131212;56527222100;55413138700;57216128993;57216132388;57207624890;57215533873;34874964500;7003418541;36196768700;55159479900;36187060600;57195263449;57216129177;7406622356;57216128560;57216130368;57216133210;57215781165;36102837500;57216129449;57216126004;57216133642;57216125772;57216126216;57216123061;6701432952;57216126900;57216127177;57216127687;57216125392;57216127775;57216130786;24344675200;56372310100;57195677262;57214113106;57216128961;57195261922;57216129583;57216123973;57214017583;57216130649;7006315208;36139727300;57216126685;57216131156;57216132966;6506896712;55480587300;57216134562;56438023400;57216127649;57215770199;53865436300;57216131180;57212275884;56467920800;57216127684;6603383457;57216133536;57216129317;57216124652;55932862600;57216123287;57216111310;57214459957;57216130830;37017623900;57216124566;57215140049;57195307837;56830526000;36933667400;57216133702;57192980111;57216131097;7102616821;57205632525;57214239916;57216130532;55374101200;57216129420;6602172030;57216135259;57216129617;57216135165;57216132419;57211836548;57216124000;57216126695;57216126109;57216132857;,"Initial public health response and interim clinical guidance for the 2019 novel coronavirus outbreak — United States, December 31, 2019–February 4, 2020",2020,American Journal of Transplantation,20,3,,889,895,,1,10.1111/ajt.15805,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079756628&doi=10.1111%2fajt.15805&partnerID=40&md5=c5f256f8d4247f728064fb2aee206f5b,"2019-nCoV CDC Response, CDC, United States","Patel, A., 2019-nCoV CDC Response, CDC, United States; Jernigan, D.B., 2019-nCoV CDC Response, CDC, United States; Abdirizak, F.; Abedi, G.; Aggarwal, S.; Albina, D.; Allen, E.; Andersen, L.; Anderson, J.; Anderson, M.; Anderson, T.; Anderson, K.; Bardossy, A.C.; Barry, V.; Beer, K.; Bell, M.; Berger, S.; Bertulfo, J.; Biggs, H.; Bornemann, J.; Bornstein, J.; Bower, W.; Bresee, J.; Brown, C.; Budd, A.; Buigut, J.; Burke, S.; Burke, R.; Burns, E.; Butler, J.; Cantrell, R.; Cardemil, C.; Cates, J.; Cetron, M.; Chatham-Stephens, K.; Chatham-Stevens, K.; Chea, N.; Christensen, B.; Chu, V.; Clarke, K.; Cleveland, A.; Cohen, N.; Cohen, M.; Cohn, A.; Collins, J.; Conners, E.; Curns, A.; Dahl, R.; Daley, W.; Dasari, V.; Davlantes, E.; Dawson, P.; Delaney, L.; Donahue, M.; Dowell, C.; Dyal, J.; Edens, W.; Eidex, R.; Epstein, L.; Evans, M.; Fagan, R.; Farris, K.; Feldstein, L.; Fox, L.; Frank, M.; Freeman, B.; Fry, A.; Fuller, J.; Galang, R.; Gerber, S.; Gokhale, R.; Goldstein, S.; Gorman, S.; Gregg, W.; Greim, W.; Grube, S.; Hall, A.; Haynes, A.; Hill, S.; Hornsby-Myers, J.; Hunter, J.; Ionta, C.; Isenhour, C.; Jacobs, M.; Jacobs Slifka, K.; Jernigan, D.; Jhung, M.; Jones-Wormley, J.; Kambhampati, A.; Kamili, S.; Kennedy, P.; Kent, C.; Killerby, M.; Kim, L.; Kirking, H.; Koonin, L.; Koppaka, R.; Kosmos, C.; Kuhar, D.; Kuhnert-Tallman, W.; Kujawski, S.; Kumar, A.; Landon, A.; Lee, L.; Leung, J.; Lindstrom, S.; Link-Gelles, R.; Lively, J.; Lu, X.; Lynch, B.; Malapati, L.; Mandel, S.; Manns, B.; Marano, N.; Marlow, M.; Marston, B.; McClung, N.; McClure, L.; McDonald, E.; McGovern, O.; Messonnier, N.; Midgley, C.; Moulia, D.; Murray, J.; Noelte, K.; Noonan-Smith, M.; Nordlund, K.; Norton, E.; Oliver, S.; Pallansch, M.; Parashar, U.; Patel, A.; Patel, M.; Pettrone, K.; Pierce, T.; Pietz, H.; Pillai, S.; Radonovich, L.; Reagan-Steiner, S.; Reel, A.; Reese, H.; Rha, B.; Ricks, P.; Rolfes, M.; Roohi, S.; Roper, L.; Rotz, L.; Routh, J.; Sakthivel, S.K.; Sarmiento, L.; Schindelar, J.; Schneider, E.; Schuchat, A.; Scott, S.; Shetty, V.; Shockey, C.; Shugart, J.; Stenger, M.; Stuckey, M.; Sunshine, B.; Sykes, T.; Uyeki, T.; Vahey, G.; Valderrama, A.; Villanueva, J.; Walker, T.; Wallace, M.; Wang, L.; Watson, J.; Weber, A.; Weinbaum, C.; Weldon, W.; Westnedge, C.; Whitaker, B.; Whitaker, M.; Williams, A.; Willams, I.; Wong, K.; Xie, A.; Yousef, A.; 2019-nCoV CDC Response Team",[No abstract available],,,"(2020) Novel coronavirus (2019-nCoV). Situation report 1, , https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200121-sitrep-1-2019-ncov.pdf?sfvrsn, Geneva, Switzerland, World Health Organization; (2020) Novel coronavirus (2019-nCoV). Situation report 15, , https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200204-sitrep-15-ncov.pdf?sfvrsn=88fe8ad6_2, Geneva, Switzerland, World Health Organization; (2020) Proclamation on suspension of entry as immigrants and nonimmigrants of persons who pose a risk of transmitting 2019 novel coronavirus, , https://www.whitehouse.gov/presidential-actions/proclamation-suspension-entry-immigrants-nonimmigrants-persons-pose-risk-transmitting-2019-novel-coronavirus/, Washington, DC, Office of the President; Holloway, R., Rasmussen, S.A., Zaza, S., Cox, N.J., Jernigan, D.B., Updated preparedness and response framework for influenza pandemics (2014) MMWR Recomm Rep., 63. , (RR-6); Reed, C., Biggerstaff, M., Finelli, L., Novel framework for assessing epidemiologic effects of influenza epidemics and pandemics (2013) Emerg Infect Dis, 19, pp. 85-91; Lu, R., Zhao, X., Li, J., Genomic characterization and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet, , Epub January 29, 2020; Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med., , Epub January 29, 2020; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, , Epub January 30, 2020; Hunag, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, , Epub January 24, 2020; Grohskopf, L.A., Alyanak, E., Broder, K.R., Walter, E.B., Fry, A.M., Jernigan, D.B., Prevention and control of seasonal influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices—United States, 2019–20 influenza season (2019) MMWR Recomm Rep., 68. , (RR-3)","Patel, A.; 2019-nCoV CDC Response, CDCUnited States; email: APatel7@cdc.gov",,Blackwell Publishing Ltd,16006135,,AJTMB,32027631,English,Am. J. Transplant.,Editorial,Final,Open Access,Scopus,2-s2.0-85079756628,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Li J.-P.O., Lam D.S.C., Chen Y., Ting D.S.W.",57215044882;57211727828;56613620900;37010354600;,Novel Coronavirus disease 2019 (COVID-19): The importance of recognising possible early ocular manifestation and using protective eyewear,2020,British Journal of Ophthalmology,104,3,,297,298,,2,10.1136/bjophthalmol-2020-315994,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079756488&doi=10.1136%2fbjophthalmol-2020-315994&partnerID=40&md5=5eb9ca22f70addbce51cab70c7914fa9,"Moorfields Eye Hospital, London, United Kingdom; C-MER Dennis Lam Eye Center, C-Mer International Eye Care Group Limited, Hong Kong, Hong Kong; International Eye Research Institute of the Chinese University of Hong Kong (Shenzhen), Shenzhen, China; Department of Ophthalmology, Peking Union Medical College Hospital, Beijing, China; Singapore National Eye Center, Singapore, Singapore; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangzhou, China","Li, J.-P.O., Moorfields Eye Hospital, London, United Kingdom; Lam, D.S.C., C-MER Dennis Lam Eye Center, C-Mer International Eye Care Group Limited, Hong Kong, Hong Kong, International Eye Research Institute of the Chinese University of Hong Kong (Shenzhen), Shenzhen, China; Chen, Y., Department of Ophthalmology, Peking Union Medical College Hospital, Beijing, China; Ting, D.S.W., Moorfields Eye Hospital, London, United Kingdom, Singapore National Eye Center, Singapore, Singapore, State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangzhou, China",[No abstract available],conjunctiva; epidemiology; infection; public health,"coronavirus disease 2019; Coronavirus infection; Editorial; eye disease; eye protection; hand washing; human; Human coronavirus NL63; infection prevention; Middle East respiratory syndrome; Middle East respiratory syndrome coronavirus; mortality; nonhuman; ophthalmologist; pandemic; prevalence; priority journal; SARS coronavirus; severe acute respiratory syndrome; viral conjunctivitis; viral contamination; Betacoronavirus; Coronavirus infection; eye; eye protective device; isolation and purification; virology; virus pneumonia; COVID-19; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; Coronavirus Infections; Eye; Eye Protective Devices; Humans; Pneumonia, Viral","World Health Organization. Pneumonia of unknown cause-China, 2020; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, , [Epub ahead of print: 24 Jan 2020]; Callaway, E., Cyranoski, D., New China virus: Five questions scientists are asking (2020) Nature News, 2020; WHO. Laboratory testing for 2019 novel coronavirus (2019-nCoV) in suspected human cases-interim guidance. 2020; 2020; Peiris, J.S.M., Yuen, K.Y., Osterhaus, A.D.M.E., The severe acute respiratory syndrome (2003) N Engl J Med, 349, pp. 2431-2441; Zaki, A.M., Van Boheemen, S., Bestebroer, T.M., Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia (2012) N Engl J Med, 367, pp. 1814-1820; Killerby, M.E., Biggs, H.M., Midgley, C.M., Middle East respiratory syndrome coronavirus transmission (2020) Emerg Infect Dis, 26, pp. 191-198; Elkholy, A.A., Grant, R., Assiri, A., MERS-CoV infection among healthcare workers and risk factors for death: Retrospective analysis of all laboratory-confirmed cases reported to WHO from 2012 to 2 June 2018 (2019) J Infect Public Health, , [Epub ahead of print: 2 May 2019]; Holmes, K.V., SARS-associated coronavirus (2003) N Engl J Med, 348, pp. 1948-1951; Otter, J.A., Donskey, C., Yezli, S., Transmission of SARS and MERS coronaviruses and influenza virus in healthcare settings: The possible role of dry surface contamination (2016) J Hosp Infect, 92, pp. 235-250; Belser, J.A., Rota, P.A., Tumpey, T.M., Ocular tropism of respiratory viruses (2013) Microbiol Mol Biol Rev, 77, pp. 144-156; Arabi, Y.M., Balkhy, H.H., Hayden, F.G., Middle East respiratory syndrome (2017) N Engl J Med, 376, pp. 584-594; Yuen, K.S.C., Chan, W.-M., Fan, D.S.P., Ocular screening in severe acute respiratory syndrome (2004) Am J Ophthalmol, 137, pp. 773-774; Loon, S.-C., Teoh, S.C.B., Oon, L.L.E., The severe acute respiratory syndrome coronavirus in tears (2004) Br J Ophthalmol, 88, pp. 861-863; Van Der Hoek, L., Pyrc, K., Jebbink, M.F., Identification of a new human coronavirus (2004) Nat Med, 10, pp. 368-373; Vabret, A., Mourez, T., Dina, J., Human coronavirus NL63, France (2005) Emerg Infect Dis, 11, pp. 1225-1229; Imai, N., Dorigatti, I., Cori, A., (2020) Report 2: Estimating the Potential Total Number of Novel Coronavirus Cases in Wuhan City, China, , Imperial College London; Jf-W, C., Yuan, S., Kok, K.-H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: A study of a family cluster (2020) Lancet, , [Epub ahead of print: 24 Jan 2020]; Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel Coronavirus-Infected pneumonia (2020) N Engl J Med; World Health Organization. Laboratory testing for 2019 novel coronavirus (2019-nCoV) in suspected human cases-Interim guidance, 2020; World Health Organization. Infection prevention and control during health care when novel coronavirus (nCoV) infection is suspected. Interim guidance, 2020; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study (2020) The Lancet; Morgan, I.G., French, A.N., Ashby, R.S., The epidemics of myopia: Aetiology and prevention (2018) Prog Retin Eye Res, 62, pp. 134-149; Wiboonchutikul, S., Manosuthi, W., Likanonsakul, S., Lack of transmission among healthcare workers in contact with a case of Middle East respiratory syndrome coronavirus infection in Thailand (2016) Antimicrob Resist Infect Control, 5, p. 21; Chan, W.-M., Liu, D.T.L., Chan, P.K.S., Precautions in ophthalmic practice in a hospital with a major acute SARS outbreak: An experience from Hong Kong (2006) Eye, 20, pp. 283-289","Ting, D.S.W.; Vitreo-retinal Department, Singapore National Eye CenterSingapore; email: daniel.ting.s.w@singhealth.com.sg",,BMJ Publishing Group,71161,,BJOPA,32086236,English,Br. J. Ophthalmol.,Editorial,Final,Open Access,Scopus,2-s2.0-85079756488,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Li G., De Clercq E.",57215524032;35399610800;,Therapeutic options for the 2019 novel coronavirus (2019-nCoV),2020,Nature reviews. Drug discovery,19,3,,149,150,,9,10.1038/d41573-020-00016-0,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079755488&doi=10.1038%2fd41573-020-00016-0&partnerID=40&md5=710760bfac8a85a05e54f56855afc77e,,"Li, G.; De Clercq, E.",[No abstract available],,"adenosine phosphate; alanine; alpha interferon; antivirus agent; coronavirus spike glycoprotein; COVID-19; macrogol; nucleoside; peginterferon alpha2a; proteinase inhibitor; recombinant protein; remdesivir; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; Coronavirus infection; drug effect; drug repositioning; genetics; hepatitis B; hepatitis C; human; Human immunodeficiency virus infection; influenza; Middle East respiratory syndrome coronavirus; pathogenicity; SARS coronavirus; virus pneumonia; Adenosine Monophosphate; Alanine; Antiviral Agents; Betacoronavirus; Coronavirus Infections; Drug Repositioning; Hepatitis B; Hepatitis C; HIV Infections; Humans; Influenza, Human; Interferon-alpha; Middle East Respiratory Syndrome Coronavirus; Nucleosides; Pneumonia, Viral; Polyethylene Glycols; Protease Inhibitors; Recombinant Proteins; SARS Virus; Spike Glycoprotein, Coronavirus",,,,NLM (Medline),14741784,,,32127666,English,Nat Rev Drug Discov,Note,Final,Open Access,Scopus,2-s2.0-85079755488,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Tang J.W., Tambyah P.A., Hui D.S.C.",10341387300;35499886400;7101862411;,"Emergence of a novel coronavirus causing respiratory illness from Wuhan, China",2020,Journal of Infection,80,3,,350,371,,8,10.1016/j.jinf.2020.01.014,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079754203&doi=10.1016%2fj.jinf.2020.01.014&partnerID=40&md5=e66b68c0b0bd1eb827e8cbe3cdc0c0da,"Clinical Microbiology, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom; Respiratory Sciences, University of Leicester, Leicester, United Kingdom; Department of Medicine, National University of Singapore, Singapore; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong","Tang, J.W., Clinical Microbiology, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom, Respiratory Sciences, University of Leicester, Leicester, United Kingdom; Tambyah, P.A., Department of Medicine, National University of Singapore, Singapore; Hui, D.S.C., Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong",[No abstract available],,"adult; case fatality rate; case report; chill; China; clinical article; comorbidity; coronavirus disease 2019; Coronavirus infection; coughing; disease transmission; dyspnea; fatigue; female; fever; headache; health service; hospital admission; hospital discharge; human; infection control; Letter; male; middle aged; Middle East respiratory syndrome; patient isolation; phylogeny; pneumonia; respiratory tract disease; rhinorrhea; seroprevalence; severe acute respiratory syndrome; sore throat; thorax radiography; animal; Betacoronavirus; Coronavirus infection; genetics; virus genome; virus pneumonia; COVID-19; severe acute respiratory syndrome coronavirus 2; Animals; Betacoronavirus; China; Coronavirus Infections; Genome, Viral; Humans; Phylogeny; Pneumonia, Viral","Al-Tawfiq, J.A., Alfaraj, S.H., Altuwaijri, T.A., Memish, Z.A., A cohort-study of patients suspected for MERS-CoV in a referral hospital in Saudi Arabia (2017) J Infect, 75 (4), pp. 378-379; Lim, W.S., Anderson, S.R., Read, R.C., SARS Guidelines Committee of the British Thoracic Society; British Infection Society; Health Protection Agency. Hospital management of adults with severe acute respiratory syndrome (SARS) if SARS re-emerges–updated 10 February 2004 (2004) J Infect, 49 (July (1)), pp. 1-7; Lu, H., Stratton, C.W., Tang, Y.W., Outbreak of pneumonia of unknown etiology in Wuhan China: the mystery and the miracle (2020) J Med Virol, , Jan 16[Epub ahead of print]; Bogoch, I.I., Watts, A., Thomas-Bachli, A., Huber, C., Kraemer, M.U.G., Khan, K., Pneumonia of unknown etiology in Wuhan, China: potential for international spread via commercial air travel (2020) J Travel Med, , Jan 14. pii: taaa008[Epub ahead of print]; Song, Z., Xu, Y., Bao, L., Zhang, L., Yu, P., Qu, Y., From SARS to MERS, thrusting coronaviruses into the spotlight (2019) Viruses, 11 (January (1)). , pii: E59; https://www.who.int/csr/don/14-january-2020-novel-coronavirus-thailand-ex-china/en/, WHO. Novel coronavirus – Thailand (ex-China). Disease outbreak news. 14 January 2020; ProMed Mail. Novel coronavirus (07): China (HU), Thailand ex China, Japan ex China, WHO. 2020. Archive Number: 20200117.6895647; https://www.who.int/thailand/news/detail/17-01-2020-update-information-on-thailand-responding-to-the-novel-coronavirus, WHO. Update information on Thailand responding to the novel coronavirus. 17 January 2020; https://www.who.int/csr/don/17-january-2020-novel-coronavirus-japan-ex-china/en/, WHO. Novel coronavirus – Japan (ex-China). disease outbreak news. 17 January 2020; Ferguson, N., Imperial College London, UK. 17 January 2020","Tang, J.W.; Clinical Microbiology, University Hospitals of Leicester NHS Trust, Level 5 Sandringham Building, Leicester Royal Infirmary, Infirmary Square, United Kingdom; email: julian.tang@uhl-tr.nhs.uk",,W.B. Saunders Ltd,1634453,,JINFD,32001309,English,J. Infect.,Letter,Final,Open Access,Scopus,2-s2.0-85079754203,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Xu Y.,57215633329;,Genetic diversity and potential recombination between ferret coronaviruses from European and American lineages,2020,Journal of Infection,80,3,,350,371,,,10.1016/j.jinf.2020.01.016,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079687167&doi=10.1016%2fj.jinf.2020.01.016&partnerID=40&md5=6053eb143fdfb7a1e1633ac60e5d7257,"Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom","Xu, Y., Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom",[No abstract available],Coronaviruses; Evolution; Ferret; Recombination,controlled study; Coronavirinae; dynamics; Europe; evolution; evolutionary dynamics; ferret coronavirus; gene sequence; genetic analysis; genetic recombination; genetic variability; Letter; N gene; nonhuman; phylogenetic tree; phylogeny; RdRp gene; S gene; United States; virus gene; virus genome; virus strain,"Chen, X., Guo, F., Pan, J., Shen, X., Li, Y., Irwin, D.M., Rare homologous recombination in H3N2 avian influenza a viruses (2019) J Infect, , Elsevier; Li, X., Xiao, K., Zhang, Z., Yang, J., Wang, R., Shen, X., The recombination hot spots and genetic diversity of the genomes of African swine fever viruses (2020) J Infect, 80, pp. 121-142. , Elsevier; Wise, A.G., Kiupel, M., Maes, R.K., Molecular characterization of a novel coronavirus associated with epizootic catarrhal enteritis (ECE) in ferrets (2006) Virology, 349, pp. 164-174. , Elsevier; Garner, M.M., Ramsell, K., Morera, N., Juan-Sallés, C., Jiménez, J., Ardiaca, M., Clinicopathologic features of a systemic coronavirus-associated disease resembling feline infectious peritonitis in the domestic ferret (Mustela putorius) (2008) Vet Pathol, 45, pp. 236-246. , SAGE Publications Sage CA: Los Angeles, CA; Provacia, L.B.V., Smits, S.L., Martina, B.E., Raj, V.S., vd Doel, P., Amerongen, G.V., Enteric coronavirus in ferrets, the Netherlands (2011) Emerg Infect Dis, 17, p. 1570. , Centers for Disease Control and Prevention; Pickett, B.E., Sadat, E.L., Zhang, Y., Noronha, J.M., Squires, R.B., Hunt, V., ViPR: an open bioinformatics database and analysis resource for virology research (2011) Nucl Acids Res, 40, pp. D593-D598. , Oxford University Press; Lole, K.S., Bollinger, R.C., Paranjape, R.S., Gadkari, D., Kulkarni, S.S., Novak, N.G., Full-length human immunodeficiency virus type 1 genomes from subtype C-infected seroconverters in India, with evidence of intersubtype recombination (1999) J Virol Am Soc Microbiol, 73, pp. 152-160; Lamers, M.M., Smits, S.L., Hundie, G.B., Provacia, L.B., Koopmans, M., Osterhaus, A.D.M.E., Naturally occurring recombination in ferret coronaviruses revealed by complete genome characterization (2016) J Gen Virol Microbiol Soc, 97, pp. 2180-2186; Minami, S., Kuroda, Y., Terada, Y., Yonemitsu, K., Van Nguyen, D., Kuwata, R., Detection of novel ferret coronaviruses and evidence of recombination among ferret coronaviruses (2016) Virus Genes, 52, pp. 858-862. , Springer; Su, S., Wong, G., Shi, W., Liu, J., Lai, A.C.K., Zhou, J., Epidemiology, genetic recombination, and pathogenesis of coronaviruses (2016) Trends Microbiol, 24, pp. 490-502. , Elsevier",,,W.B. Saunders Ltd,1634453,,JINFD,32006540,English,J. Infect.,Letter,Final,Open Access,Scopus,2-s2.0-85079687167,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Xiang Y.-T., Yang Y., Li W., Zhang L., Zhang Q., Cheung T., Ng C.H.",35241398400;57192547943;57207123325;55357770500;57214996997;56828857900;57211807019;,Timely mental health care for the 2019 novel coronavirus outbreak is urgently needed,2020,The Lancet Psychiatry,7,3,,228,229,,12,10.1016/S2215-0366(20)30046-8,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079612108&doi=10.1016%2fS2215-0366%2820%2930046-8&partnerID=40&md5=0a41b2b7ae3114808f2ee32c7b3dae45,"Unit of Psychiatry, Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao, China; Center for Cognition and Brain Sciences, University of Macau, Macao, China; Department of Psychiatry, Southern Medical University Nanfang Hospital & Guangdong-Hong Kong-Macao Greater Bay Area Center for Brian Science and Brain-Inspired Intelligence, Guangdong, China; National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital & the Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China; School of Nursing, Hong Kong Polytechnic University, Hong Kong, Hong Kong; Department of Psychiatry, The Melbourne Clinic and St Vincent's Hospital, University of Melbourne, Richmond, VIC, Australia","Xiang, Y.-T., Unit of Psychiatry, Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao, China, Center for Cognition and Brain Sciences, University of Macau, Macao, China; Yang, Y., Unit of Psychiatry, Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao, China, Center for Cognition and Brain Sciences, University of Macau, Macao, China, Department of Psychiatry, Southern Medical University Nanfang Hospital & Guangdong-Hong Kong-Macao Greater Bay Area Center for Brian Science and Brain-Inspired Intelligence, Guangdong, China; Li, W., Unit of Psychiatry, Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao, China, Center for Cognition and Brain Sciences, University of Macau, Macao, China; Zhang, L., National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital & the Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China; Zhang, Q., National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital & the Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China; Cheung, T., School of Nursing, Hong Kong Polytechnic University, Hong Kong, Hong Kong; Ng, C.H., Department of Psychiatry, The Melbourne Clinic and St Vincent's Hospital, University of Melbourne, Richmond, VIC, Australia",[No abstract available],,"2019 novel coronavirus; anger; anxiety; boredom; China; clinical psychology; contact examination; Coronavirinae; Coronavirus infection; counseling; crisis intervention; delirium; depression; distress syndrome; epidemic; excitement; fear; frustration; human; loneliness; mental health care; mental health care personnel; mobile application; nonhuman; Note; nurse; panic; posttraumatic stress disorder; priority journal; psychiatrist; psychosis; psychotherapy; quarantine; severe acute respiratory syndrome; suicidal behavior; virus pneumonia; virus transmission; civil defense; Coronavirinae; Coronavirus infection; growth, development and aging; health care personnel; health care planning; interpersonal communication; isolation and purification; legislation and jurisprudence; mental health; procedures; psychology; traffic and transport; virology; China; Civil Defense; Communication; Coronavirus; Coronavirus Infections; Crisis Intervention; Disease Outbreaks; Health Personnel; Health Plan Implementation; Humans; Mental Health; Quarantine; Transportation","Wang, C., Horby, P.W., Hayden, F.G., Gao, G.F., A novel coronavirus outbreak of global health concern (2020) Lancet, , published online Jan 24; Wang, X., Coronavirus outbreak: 444 new cases added on Friday. Jan 25, 2020. China Daily http://www.chinadaily.com.cn/a/202001/25/WS5e2bad63a310128217273336.html, (Accessed 25 January 2020); Xiang, Y.T., Yu, X., Ungvari, G.S., Correll, C.U., Chiu, H.F., Outcomes of SARS survivors in China: not only physical and psychiatric co-morbidities (2014) East Asian Arch Psychiatry, 24, pp. 37-38; Chan, J.F.W., Yuan, S., Kok, K.H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, , published online Jan 24; Principles for emergency psychological crisis intervention for the new coronavirus pneumonia (in Chinese) http://www.nhc.gov.cn/jkj/s3577/202001/6adc08b966594253b2b791be5c3b9467.shtml, (Accessed 26 January 2020); Liu, T.B., Chen, X.Y., Miao, G.D., Recommendations on diagnostic criteria and prevention of SARS-related mental disorders (2003) J Clin Psychol Med, 13, pp. 188-191. , (in Chinese); Maunder, R., Hunter, J., Vincent, L., The immediate psychological and occupational impact of the 2003 SARS outbreak in a teaching hospital (2003) CMAJ, 168, pp. 1245-1251; Wu, P., Fang, Y., Guan, Z., The psychological impact of the SARS epidemic on hospital employees in China: exposure, risk perception, and altruistic acceptance of risk (2009) Can J Psychiatry, 54, pp. 302-311; Wei, Y.L., Han, B., Liu, W., Liu, G., Huang, Y., (2004), Psychosomatic discomfort and related factors among 1,411 first-line SARS staff in Beijing. Manual of the 7th national experimental medicine symposium of Chinese Society of Integrated Traditional Chinese and Western Medicine; Beijing, China; July 6–12 (in Chinese); Folkman, S., Greer, S., Promoting psychological well-being in the face of serious illness: when theory, research and practice inform each other (2000) Psychooncology, 9, pp. 11-19",,,Elsevier Ltd,22150366,,,32032543,English,Lancet Psychiatry,Note,Final,Open Access,Scopus,2-s2.0-85079612108,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wang R., Zhang X., Irwin D.M., Shen Y.",35263124400;57072241300;57214786042;35312068500;,Emergence of SARS-like coronavirus poses new challenge in China,2020,Journal of Infection,80,3,,350,371,,5,10.1016/j.jinf.2020.01.017,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079606866&doi=10.1016%2fj.jinf.2020.01.017&partnerID=40&md5=be7efdd998630a951b9e06565ea51d6a,"College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China; Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, Guangzhou, 510642, China; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, M5S 1A8, Canada; Banting and Best Diabetes Centre, University of Toronto, Toronto, M5S 1A8, Canada","Wang, R., College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China; Zhang, X., College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China; Irwin, D.M., Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, M5S 1A8, Canada, Banting and Best Diabetes Centre, University of Toronto, Toronto, M5S 1A8, Canada; Shen, Y., College of Veterinary Medicine, South China Agricultural University, Guangzhou, 510642, China, Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, Guangzhou, 510642, China",[No abstract available],,2019 novel coronavirus; acute diarrhea; China; Coronavirus infection; epidemic; human; infection control; Letter; Middle East respiratory syndrome; nonhuman; public health; SARS-related coronavirus; sequence homology; severe acute respiratory syndrome; swine acute diarrhea syndrome coronavirus infection; virus detection; virus genome; virus transmission; wild animal,"Shen, X., Pu, Z., Li, Y., Yu, S., Guo, F., Luo, T., Phylogeographic patterns of the African swine fever virus (2019) J Infect, 79 (2), pp. 174-187; Li, X., Xiao, K., Zhang, Z., Yang, J., Wang, R., Shen, X., The recombination hot spots and genetic diversity of the genomes of African swine fever viruses (2020) J Infect, 80 (1), pp. 121-142; Song, Z., Xu, Y., Bao, L., Zhang, L., Yu, P., Qu, Y., From SARS to MERS, thrusting coronaviruses into the spotlight (2019) Viruses, 11 (1), p. E59; Zhou, P., Fan, H., Lan, T., Yang, X.L., Shi, W.F., Zhang, W., Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin (2018) Nature, 556 (7700), pp. 255-258; Gong, L., Li, J., Zhou, Q., Xu, Z., Chen, L., Zhang, Y., A new bat-HKU2-like coronavirus in swine, China, 2017 (2017) Emerg Infect Dis., 23 (9), p. 1607; Ge, X.Y., Li, J.L., Yang, X.L., Chmura, A.A., Zhu, G., Epstein, J.H., Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor (2013) Nature, 503 (7477), pp. 535-538; Li, W., Shi, Z., Yu, M., Ren, W., Smith, C., Epstein, J.H., Bats are natural reservoirs of SARS-Like coronaviruses (2005) Science, 310 (5748), pp. 676-679; Guan, Y., Zheng, B.J., He, Y.Q., Liu, X.L., Zhuang, Z.X., Cheung, C.L., Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China (2003) Science, 302 (5643), pp. 276-278; Woo, P.C.Y., Huang, Y., Lau, S.K.P., Yuen, K.-Y., Coronavirus genomics and bioinformatics analysis (2010) Viruses, 2 (8), pp. 1804-1820","Shen, Y.; College of Veterinary Medicine, South China Agricultural UniversityChina; email: shenyy@scau.edu.cn",,W.B. Saunders Ltd,1634453,,JINFD,32007524,English,J. Infect.,Letter,Final,Open Access,Scopus,2-s2.0-85079606866,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Kang L., Li Y., Hu S., Chen M., Yang C., Yang B.X., Wang Y., Hu J., Lai J., Ma X., Chen J., Guan L., Wang G., Ma H., Liu Z.",57214998984;57215014512;55262467300;57215007979;55576691600;57195756147;56002586200;57214939234;56988340800;57214931980;57212281663;57207384818;7407147911;57214783094;57203906332;,"The mental health of medical workers in Wuhan, China dealing with the 2019 novel coronavirus",2020,The Lancet Psychiatry,7,3,,e14,,,6,10.1016/S2215-0366(20)30047-X,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079594954&doi=10.1016%2fS2215-0366%2820%2930047-X&partnerID=40&md5=651b09efcf4cce6d63dd79a03d2ae7dc,"Department of Psychiatry, RenMin Hospital of Wuhan University, Wuhan, 430060, China; Wuhan Mental Health Center, Wuhan, China; Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; The School of Computer Science and Technology, Huazhong University of Science and Technology, Wuhan, China; School of Health Sciences, Wuhan University, Wuhan, China; Department of Psychiatry, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China; Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China","Kang, L., Department of Psychiatry, RenMin Hospital of Wuhan University, Wuhan, 430060, China; Li, Y., Wuhan Mental Health Center, Wuhan, China; Hu, S., Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Chen, M., The School of Computer Science and Technology, Huazhong University of Science and Technology, Wuhan, China; Yang, C., Department of Psychiatry, RenMin Hospital of Wuhan University, Wuhan, 430060, China; Yang, B.X., School of Health Sciences, Wuhan University, Wuhan, China; Wang, Y., Department of Psychiatry, RenMin Hospital of Wuhan University, Wuhan, 430060, China; Hu, J., Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Lai, J., Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Ma, X., Department of Psychiatry, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China; Chen, J., Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Guan, L., Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China; Wang, G., Department of Psychiatry, RenMin Hospital of Wuhan University, Wuhan, 430060, China; Ma, H., Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China; Liu, Z., Department of Psychiatry, RenMin Hospital of Wuhan University, Wuhan, 430060, China",[No abstract available],,anger; anxiety; China; Chinese; Coronavirinae; Coronavirus infection; denial; depression; epidemic; fear; general hospital; human; insomnia; Letter; medical personnel; mental health; nonhuman; pneumonia; priority journal; stress; Betacoronavirus; Coronavirinae; global health; mental health; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; China; Coronavirus; Disease Outbreaks; Global Health; Humans; Mental Health,"Wang, C., Horby, P.W., Hayden, F.G., Gao, G.F., A novel coronavirus outbreak of global health concern (2020) Lancet, , published online Jan 24; Emerging understandings of 2019-nCoV (2020) Lancet, , published online Jan 24; Occupational injury insurance supports occupational injury “protection umbrella” for prevention and rescue personnel in the fight against new coronavirus pneumonia http://www.nhc.gov.cn/xcs/fkdt/202001/0ffbb879ac1b4466b01de8b40a1372fc.shtml, (Accessed 26 January 2020); The guideline of psychological crisis intervention for 2019-nCoV pneumonia http://www.nhc.gov.cn/jkj/s3577/202001/6adc08b966594253b2b791be5c3b9467.shtml, (Accessed 27 January 2020); von Keudell, A., Koh, K.A., Shah, S.B., Mental health after the Boston marathon bombing (2016) Lancet Psychiatry, 3, pp. 802-804",,,Elsevier Ltd,22150366,,,32035030,English,Lancet Psychiatry,Letter,Final,Open Access,Scopus,2-s2.0-85079594954,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Li X., Song Y., Wong G., Cui J.",57214931191;57214932864;57214937976;36162804500;,Bat origin of a new human coronavirus: there and back again,2020,Science China Life Sciences,63,3,,461,462,,1,10.1007/s11427-020-1645-7,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079531977&doi=10.1007%2fs11427-020-1645-7&partnerID=40&md5=81e0ac93662871e19eadbb465b8e1423,"CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China; Center for Biosafety Mega-Science, Chinese Academy of Sciences, Shanghai, 200031, China; University of Chinese Academy of Sciences, Beijing, 100049, China; School of Life Sciences, Shanghai University, Shanghai, 200444, China","Li, X., CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China, University of Chinese Academy of Sciences, Beijing, 100049, China; Song, Y., School of Life Sciences, Shanghai University, Shanghai, 200444, China; Wong, G., CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Shanghai, 200031, China; Cui, J., CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Shanghai, 200031, China",[No abstract available],,,"Chan, J.F.W., Yuan, S., Kok, K.H., To, K.K.W., Chu, H., Yang, J., Xing, F., Poon, R.W.S., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet; Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Wei, Y., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet; Hu, B., Zeng, L.P., Yang, X.L., Ge, X.Y., Zhang, W., Li, B., Xie, J.Z., Wang, N., Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus (2017) PLoS Pathog, 13; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Gu, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet; Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Ren, R.L.K.S.M., Wong, J.Y., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med; Lu, R., Zhao, X., Li, J., Niu, P., Yang, B., Wu, H., Wang, W., Zhu, N., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet; Wei, X., Li, X., Cui, J., Evolutionary perspectives on novel coronaviruses identified in pneumonia cases in China (2020) Natl Sci Rev; Wu, C.I., Poo, M., Very fast evolution, not-so-fast publication— A proposed solution (2020) Natl Sci Rev; Wu, F., Zhao, S., Yu, B., Chen, Y.M., Wang, W., Song, Z.G., Hu, Y., Pei, Y.Y., A new coronavirus associated with human respiratory disease in China (2020) Nature; Xu, X., Chen, P., Wang, J., Feng, J., Zhou, H., Li, X., Zhong, W., Hao, P., Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission (2020) Sci China Life Sci; Yu, P., Hu, B., Shi, Z.L., Cui, J., Geographical structure of bat SARS-related coronaviruses (2019) Infect Genet Evol, 69, pp. 224-229; Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., Zhao, X., Lu, R., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med; Zhou, P., Yang, X.L., Wang, X.G., Hu, B., Zhang, L., Zhang, W., Si, H.R., Huang, C.L., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature","Cui, J.; CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of SciencesChina; email: jcui@ips.ac.cn",,Science in China Press,16747305,,,32048160,English,Sci. China Life Sci.,Note,Final,Open Access,Scopus,2-s2.0-85079531977,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Chen P., Mao L., Nassis G.P., Harmer P., Ainsworth B.E., Li F.",26659806300;57209800978;6603145277;6603921559;35399560800;7406055383;,Wuhan coronavirus (2019-nCoV): The need to maintain regular physical activity while taking precautions,2020,Journal of Sport and Health Science,9,2,,103,104,,,10.1016/j.jshs.2020.02.001,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079385506&doi=10.1016%2fj.jshs.2020.02.001&partnerID=40&md5=becffe10724ef239e99dd409b1d18df1,"Shanghai University of Sport, Shanghai, 200438, China; Shanghai Municipal Education Commission, Shanghai, 200003, China; Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, 5230, Denmark; Department of Exercise and Health Science, Willamette University, Salem, OR 97301, United States; School of Nutrition and Health Promotion, Arizona State University, Phoenix, AZ 85004, United States; Oregon Research Institute, Eugene, OR 97403, United States","Chen, P., Shanghai University of Sport, Shanghai, 200438, China; Mao, L., Shanghai University of Sport, Shanghai, 200438, China, Shanghai Municipal Education Commission, Shanghai, 200003, China; Nassis, G.P., Shanghai University of Sport, Shanghai, 200438, China, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, 5230, Denmark; Harmer, P., Department of Exercise and Health Science, Willamette University, Salem, OR 97301, United States; Ainsworth, B.E., Shanghai University of Sport, Shanghai, 200438, China, School of Nutrition and Health Promotion, Arizona State University, Phoenix, AZ 85004, United States; Li, F., Oregon Research Institute, Eugene, OR 97403, United States",[No abstract available],,Coronavirus infection; covid 19; exercise; home; home environment; human; immune system; mental health; Note; physical activity; priority journal; public health; stretching exercise; World Health Organization,"(2005), https://www.who.int/news-room/detail/30-01-2020-statement-on-the-second-meeting-of-the-international-health-regulations–emergency-committee-regarding-the-outbreak-of-novel-coronavirus-(2019-ncov), World Health Organization. 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(2020) Nature; Callaway, E., Cyranoski, D., China coronavirus: six questions scientists are asking (2020) Nature, 577, pp. 605-607; http://www.xinhuanet.com/english/2020-01/24/c_138731835.htm, XINHUANET. Xinhua Headlines: China mobilizes medical teams to fight new coronavirus. Available at: [accessed 01.02.2020]; http://www.nhc.gov.cn/xcs/zhengcwj/202001/d9ae8301384a4239a8041d6f77da09b6.shtml, National Health Commission of the People's Republic of China. Notice on printing and distributing guidelines for health protection of pneumonia infected by new coronavirus in public places. Available at: [accessed 31.01.2020]. [in Chinese]; https://www.who.int/emergencies/diseases/novel-coronavirus-2019/advice-for-public, World Health Organization. Novel coronavirus (2019-nCoV) advice for the public. Available at: [accessed 30.01.2020]; https://www.cdc.gov/coronavirus/2019-ncov/hcp/guidance-prevent-spread.html?CDC_AA_refVal=https%3A%2F%2Fwww.cdc.gov%2Fcoronavirus%2F2019-ncov%2Fguidance-prevent-spread.html, Centers for Disease Control and Prevention. Interim guidance for persons who may have 2019 Novel Coronavirus (2019-nCoV) to prevent spread in homes and residential communities. Available at: [accessed 08.02.2020]; Owen, N., Sparling, P.B., Healy, G.N., Dunstan, D.W., Matthews, C.E., Sedentary behavior: emerging evidence for a new health risk (2010) Mayo Clin Proc, 85, pp. 1138-1141; Guo, Y., Qiu, P., Liu, T., Tai Ji Quan: an overview of its history, health benefits, and cultural value (2014) J Sport Health Sci, 3, pp. 3-8; https://nccih.nih.gov/health/yoga/introduction.htm, National Center for Complementary and Integrative Health. Yoga: what you need to know. Available at: [accessed 01.02.2020]; Tate, D.F., Lyons, E.J., Valle, C.G., High-tech tools for exercise motivation: use and role of technologies such as the internet, mobile applications, social media, and video games (2015) Diabetes Spectr, 28, pp. 45-54; Physical activity guidelines for Americans (2018), 2nd ed. U.S. Department of Health and Human Services Washington, DC; Luan, X., Tian, X., Zhang, H., Huang, R., Li, N., Chen, P., Exercise as a prescription for patients with various diseases (2019) J Sport Health Sci, 8, pp. 422-441; Zhu, W., If you are physically fit, you will live a longer and healthier life: An interview with Dr. Steven N. Blair (2019) J Sport Health Sci, 8, pp. 524-526","Chen, P.; Shanghai University of SportChina; email: chenpeijie@sus.edu.cn",,Elsevier B.V.,20952546,,,,English,J. Sport Health Sci.,Note,Final,Open Access,Scopus,2-s2.0-85079385506,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Zhu W.,7404232532;,"Should, and how can, exercise be done during a coronavirus outbreak? An interview with Dr. Jeffrey A. Woods",2020,Journal of Sport and Health Science,9,2,,105,107,,,10.1016/j.jshs.2020.01.005,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079280938&doi=10.1016%2fj.jshs.2020.01.005&partnerID=40&md5=67bd2a28b605469dd8f9f9056611e8b1,"Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States","Zhu, W., Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL 61801, United States",[No abstract available],,,"Woods, J.A., Keylock, K.T., Lowder, T., Vieira, V.J., Zelkovich, W., Dumich, S., Cardiovascular exercise training extends influenza vaccine seroprotection in sedentary older adults: the immune function intervention trial (2009) J Am Geriatr Soc, 57, pp. 2183-2191; Lowder, T., Padgett, D.A., Woods, J.A., Moderate exercise protects mice from death due to influenza virus (2005) Brain Behav Immun, 19, pp. 377-380; Barrett, B., Hayney, M.S., Muller, D., Rakel, D., Ward, A., Obasi, C.N., Meditation or exercise for preventing acute respiratory infection: a randomized controlled trial (2012) Ann Fam Med, 10, pp. 337-346; Nieman, D.C., Wentz, L.M., The compelling link between physical activity and the body's defense system (2019) J Sport Health Sci, 8, pp. 201-217; Dimitrov, S., Hulteng, E., Hong, S., Inflammation and exercise: inhibition of monocytic intracellular TNF production by acute exercise via β2-adrenergic activation (2017) Brain Behav Immun, 61, pp. 60-68; Campbell, J.P., Turner, J.E., Debunking the myth of exercise-induced immune suppression: redefining the impact of exercise on immunological health across the lifespan (2018) Front Immunol, 9, p. 648; Yang, Y., Verkuilen, J., Rosengren, K.S., Mariani, R.A., Reed, M., Grubisich, S.A., Effects of a Taiji and Qigong intervention on the antibody response to influenza vaccine in older adults (2007) Am J Chin Med, 35, pp. 597-607; Falkenberg, R.I., Eising, C., Peters, M.L., Yoga and immune system functioning: a systematic review of randomized controlled clinical trials (2018) J Behav Med, 41, pp. 467-482",,,Elsevier B.V.,20952546,,,,English,J. Sport Health Sci.,Article,Final,Open Access,Scopus,2-s2.0-85079280938,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Singer D.R.J.,7202163382;,A new pandemic out of China: the Wuhan 2019-nCoV coronavirus syndrome,2020,Health Policy and Technology,9,1,,1,2,,,10.1016/j.hlpt.2020.02.001,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079272171&doi=10.1016%2fj.hlpt.2020.02.001&partnerID=40&md5=74cb845a1d5a4a88848c5ca49e13ceec,"Fellowship of Postgraduate Medicine, 11 Chandos Street, London, W1G 9EB, United Kingdom","Singer, D.R.J., Fellowship of Postgraduate Medicine, 11 Chandos Street, London, W1G 9EB, United Kingdom",[No abstract available],,2019 novel coronavirus; China; Coronavirinae; Coronavirus infection; Ebola hemorrhagic fever; Editorial; human; Middle East respiratory syndrome; pandemic; priority journal; severe acute respiratory syndrome; Zika fever,"Hui, D.S.C., Zumla, A., Severe acute respiratory syndrome: historical, epidemiologic, and clinical features (2019) Infect Dis Clin North Am, 33 (4), pp. 869-889; Bleibtreu, A., Bertine, M., Bertin, C., Houhou-Fidouh, N., Visseaux, B., Focus on middle east respiratory syndrome coronavirus (MERS-CoV) (2019) Med Mal Infect, , pii: S0399-077X(19)31054-6, doi:. [Epub ahead of print]; Bell, B.P., Damon, I.K., Jernigan, D.B., Kenyon, T.A., Nichol, S.T., O'Connor, J.P., Overview, control strategies, and lessons learned in the CDC response to the 2014–2016 Ebola epidemic (2016) Morb Mortal Wkly Rep, 65 (3), pp. 4-11; Musso, D., Ko, A.I., Baud, D., Zika virus infection - After the pandemic (2019) N Engl J Med, 381 (15), pp. 1444-1457; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, , pii: S0140-6736(20)30183-5; DR Congo: managing Ebola virus in war (2018) Lancet, 392 (10155), p. 1280; https://www.cdc.gov/zika, Zika virus. Centers for disease control and prevention; Griffiths, J., Woodyatt, A., (2020), https://edition.cnn.com/2020/01/28/asia/wuhan-coronavirus-update-intl-hnk, Wuhan CoV death toll from Wuhan coronavirus tops 100 as infection rate accelerates. CNN Website; (2020), www.ecdc.europa.eu/en/geographical-distribution-2019-ncov-cases, Website for the European Centre for Disease Prevention and Control. Geographical distribution of 2019-nCov cases. 7th February 2020. Accessed 7th February; www.bbc.co.uk/news/world-asia-china-51409801, BBC Website. Li Wenliang: Coronavirus death of Wuhan doctor sparks anger. 7th February 2020; Griffiths, J., Woodyatt, A., https://edition.cnn.com/2020/01/26/asia/wuhan-coronavirus-update-intl-hnk, China goes into emergency mode as number of confirmed Wuhan coronavirus cases reaches 2700. CNN website. 2020",,,Elsevier B.V.,22118837,,,,English,Health Policy Technol.,Editorial,Final,Open Access,Scopus,2-s2.0-85079272171,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Ena J., Wenzel R.P.",7004155968;57214838251;,A Novel Coronavirus Emerges [Un nuevo coronavirus emerge],2020,Revista Clinica Espanola,220,2,,115,116,,,10.1016/j.rce.2020.01.001,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079266250&doi=10.1016%2fj.rce.2020.01.001&partnerID=40&md5=3d1455f49db8382de2b65ab4b35800b3,"Departamento de Medicina Interna. Hospital Marina Baixa, Alicante, Spain; Departamento de Medicina Interna. Universidad de la Commonwealth de Virginia. Richmond, Virginia, United States","Ena, J., Departamento de Medicina Interna. Hospital Marina Baixa, Alicante, Spain; Wenzel, R.P., Departamento de Medicina Interna. Universidad de la Commonwealth de Virginia. Richmond, Virginia, United States",[No abstract available],,Coronavirinae; Editorial; nonhuman,"de Wilde, A.H., Snijder, E.J., Kikkert, M., van Hemert, M.J., Host Factors in Coronavirus Replication (2018) Curr Top Microbiol Immunol., 419, pp. 1-42; Ji, W., Wang, W., Zhao, X., Zai, J., Li, X., Homologous recombination within the spike glycoprotein of the newly identified coronavirus may boost cross-species transmission from snake to human (2020) J Med Virol., 22. , doi: 10.1002/jmv.25682; Ksiazek, T.G., Erdman, D., Goldsmith, C.S., Zaki, S.R., Peret, T., Emery, S., A novel coronavirus associated with severe acute respiratory syndrome (2003) N Engl J Med., 348, pp. 1953-1966. , 15; Assiri, A., McGeer, A., Perl, T.M., Price, C.S., Al Rabeeah, A.A., Cummings, D.A., Hospital outbreak of Middle East respiratory syndrome coronavirus (2013) N Engl J Med., 369, pp. 407-416; (2020), http://promedmail.org/post/20200122.6906927, 2019-NCOV-China (Wuhan) (06) brote, aumento de casos, medidas urgentes de contención. In: Access January 25; Yuan, L., (2020), https://www.nytimes.com/2020/01/22/health/virus-corona.html?partner, China Silences Critics Over Deadly Virus Outbreak. New York Times Published Jan. 22, 2020 Updated Jan. 25, 2020, 11:05 a.m In: = msn, access January 25; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, J., Clinical features of patients infected with 2019 novel coronavirus in Wuhan (2020) China. The Lancet. Published online January, 24. , doi: 10.1016/S0140-6736(20) 30183-5; Azhar, E.I., Hui, D.S.C., Memish, Z.A., Drosten, C., Zumla, A., The Middle East Respiratory Syndrome (MERS) (2019) Infect Dis Clin North Am., 33, pp. 891-905; Graham, B.S., Mascola, J.R., Fauci, A.S., Novel Vaccine Technologies: Essential Components of an Adequate Response to Emerging Viral Diseases (2018) JAMA., 319, pp. 1431-1432; (2020), https://emergency.cdc.gov/han/han00426.asp, Centers for Disease Control and Prevention Health Alert Network. Update and interim guidance on outbreak of 2019 novel coronavirus (2019-nCoV) in Wuhan, China. Accessed January 21; (2020), https://www.who.int/publications-detail/infection-prevention-and-control-during-health-care-when-novel-coronavirus-(ncov)-infection-is-suspected, World Health Organization. Infection prevention and control during health care when novel coronavirus (nCoV) infection is suspected. In: access January 25","Ena, J.; Departamento de Medicina Interna. Hospital Marina BaixaSpain; email: ena_jav@yahoo.es",,Elsevier Doyma,142565,,RCESA,,English; Spanish,Rev. Clin. Esp.,Editorial,Final,Open Access,Scopus,2-s2.0-85079266250,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wang M., Cao R., Zhang L., Yang X., Liu J., Xu M., Shi Z., Hu Z., Zhong W., Xiao G.",24529212300;36167910100;55444760600;57214939296;57196292096;57205225456;57215374642;7404210963;35424990900;8237740300;,Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro,2020,Cell Research,30,3,,269,271,,42,10.1038/s41422-020-0282-0,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079126550&doi=10.1038%2fs41422-020-0282-0&partnerID=40&md5=4bbae9b5f9252ad7e5525a4fb900956a,"State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China; National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China","Wang, M., State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China; Cao, R., National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China; Zhang, L., State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China; Yang, X., State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China; Liu, J., State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China; Xu, M., State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China; Shi, Z., State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China; Hu, Z., State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China; Zhong, W., National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China; Xiao, G., State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China",[No abstract available],,"adenosine phosphate; alanine; antimalarial agent; antivirus agent; chloroquine; cholecystokinin octapeptide; COVID-19; remdesivir; severe acute respiratory syndrome coronavirus 2; animal; Betacoronavirus; bioassay; Chlorocebus aethiops; Coronavirus infection; drug development; drug effect; human; Middle East respiratory syndrome coronavirus; pathogenicity; preclinical study; SARS coronavirus; Vero cell line; virus pneumonia; Adenosine Monophosphate; Alanine; Animals; Antimalarials; Antiviral Agents; Betacoronavirus; Biological Assay; Chlorocebus aethiops; Chloroquine; Coronavirus Infections; Drug Discovery; Drug Evaluation, Preclinical; Humans; Middle East Respiratory Syndrome Coronavirus; Pneumonia, Viral; SARS Virus; Sincalide; Vero Cells","Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Cao, B., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) The Lancet, 395 (10223), pp. 497-506; Zhou, P., Nature, , accepted; Zumla, A., Chan, J.F., Azhar, E.I., Hui, D.S., Yuen, K.Y., (2016) Nat. Rev. Drug Discov., 15, pp. 327-347. , COI: 1:CAS:528:DC%2BC28XisVyru70%3D; Oestereich, L., (2014) Antivir. Res., 105, pp. 17-21. , COI: 1:CAS:528:DC%2BC2cXmsVKrtbg%3D; Sheahan, T.P., (2017) Sci. Transl. Med., 9, p. eaal3653; Mulangu, S., (2019) N. Engl. J. Med., 381, pp. 2293-2303. , COI: 1:CAS:528:DC%2BC1MXisVylsLzP; Warren, T.K., (2016) Nature, 531, pp. 381-385. , COI: 1:CAS:528:DC%2BC28XjvVGnu70%3D; Savarino, A., Di Trani, L., Donatelli, I., Cauda, R., Cassone, A., (2006) Lancet Infect. Dis., 6, pp. 67-69; Yan, Y., (2013) Cell Res., 23, pp. 300-302. , COI: 1:CAS:528:DC%2BC3sXitVCmsr0%3D; Vincent, M.J., (2005) Virol. J., 2, p. 69; Mackenzie, A.H., (1983) Am. J. Med., 75, pp. 40-45. , COI: 1:STN:280:DyaL3s3ltlWrtg%3D%3D","Hu, Z.; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of SciencesChina; email: huzh@wh.iov.cn",,Springer Nature,10010602,,,32020029,English,Cell Res.,Letter,Final,Open Access,Scopus,2-s2.0-85079126550,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Bassetti M., Vena A., Giacobbe D.R.",57206668681;37032089400;51664781300;,The novel Chinese coronavirus (2019-nCoV) infections: Challenges for fighting the storm,2020,European Journal of Clinical Investigation,50,3, e13209,,,,3,10.1111/eci.13209,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079070836&doi=10.1111%2feci.13209&partnerID=40&md5=ea1019d298371d8c057a838a2b3e8806,"Department of Health Sciences, University of Genoa, Genoa, Italy; Clinica Malattie Infettive, Ospedale Policlinico San Martino–IRCCS, Genoa, Italy","Bassetti, M., Department of Health Sciences, University of Genoa, Genoa, Italy, Clinica Malattie Infettive, Ospedale Policlinico San Martino–IRCCS, Genoa, Italy; Vena, A., Department of Health Sciences, University of Genoa, Genoa, Italy, Clinica Malattie Infettive, Ospedale Policlinico San Martino–IRCCS, Genoa, Italy; Giacobbe, D.R., Department of Health Sciences, University of Genoa, Genoa, Italy, Clinica Malattie Infettive, Ospedale Policlinico San Martino–IRCCS, Genoa, Italy",[No abstract available],,"angiotensin converting enzyme 2; dipeptidyl peptidase IV; gamma interferon; granulocyte colony stimulating factor receptor; lopinavir plus ritonavir; procalcitonin; remdesivir; tumor necrosis factor; COVID-19; severe acute respiratory syndrome coronavirus 2; 2019 novel coronavirus infection; antiviral therapy; case fatality rate; computer assisted tomography; Coronavirus infection; drug efficacy; drug safety; dyspnea; Editorial; fatality; heart injury; hospital patient; human; intensive care unit; intermediate host; laboratory diagnosis; laboratory test; leukopenia; lower respiratory tract; lymphocytopenia; mathematical model; medical decision making; Middle East respiratory syndrome; positive-strand RNA virus; priority journal; randomized controlled trial (topic); SARS coronavirus; severe acute respiratory syndrome; virus pneumonia; Betacoronavirus; Coronavirus infection; genetics; pandemic; virus pneumonia; Betacoronavirus; Coronavirus Infections; Humans; Pandemics; Pneumonia, Viral","Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, , https://doi.org/10.1056/NEJMoa2001017; Geographical distribution of 2019-nCov cases globally, , https://www.ecdc.europa.eu/en/geographical-distribution-2019-ncov-cases, [Accessed 30 Jan 2020; 1540 CET]; Paules, C.I., Marston, H.D., Fauci, A.S., Coronavirus infections-more than just the common cold (2020) JAMA, , https://doi.org/10.1001/jama.2020.0757; Munster, V.J., Koopmans, M., van Doremalen, N., van Riel, D., de Wit, E., A novel coronavirus emerging in China — key questions for impact assessment (2020) N Engl J Med, , https://doi.org/10.1056/NEJMp2000929; Xu, X., Chen, P., Wang, J., Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission (2020) Sci China Life Sci, 63. , https://doi.org/10.1007/s11427-020-1637-5; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, , https://doi.org/10.1016/S0140-6736(20)30183-5; Report 3: Transmissibility of 2019-nCoV, , https://www.imperial.ac.uk/media/imperial-college/medicine/sph/ide/gida-fellowships/Imperial-2019-nCoV-transmissibility.pdf, [accessed 30 Jan 2020; 1541 CET]; Ji, W., Wang, W., Zhao, X., Zai, J., Li, X., Homologous recombination within the spike glycoprotein of the newly identified coronavirus may boost cross-species transmission from snake to human (2020) J Med Virol, , https://doi.org/10.1002/jmv.25682; Callaway, E., Cyranoski, D., Why snakes probably aren't spreading the new China virus (2020) Nature, , https://doi.org/10.1038/d41586-020-00180-8; Yu, I.T., Li, Y., Wong, T.W., Evidence of airborne transmission of the severe acute respiratory syndrome virus (2004) N Engl J Med, 350 (17), pp. 1731-1739; Zumla, A., Hui, D.S., Perlman, S., Middle East respiratory syndrome (2015) Lancet, 386 (9997), pp. 995-1007; Corman, V.M., Landt, O., Kaiser, M., Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR (2020) Eurosurveillance, 25 (3); Heymann, D.L., Data sharing and outbreaks: best practice exemplified (2020) The Lancet, , https://doi.org/10.1016/S0140-6736(20)30184-7; de Wit, E., van Doremalen, N., Falzarano, D., Munster, V.J., SARS and MERS: recent insights into emerging coronaviruses (2016) Nat Rev Microbiol, 14 (8), pp. 523-534; Mo, Y., Fisher, D., A review of treatment modalities for Middle East Respiratory Syndrome (2016) J Antimicrob Chemother, 71 (12), pp. 3340-3350","Bassetti, M.; Department of Health Sciences, University of GenoaItaly; email: matteo.bassetti@unige.it",,Blackwell Publishing Ltd,142972,,EJCIB,32003000,English,Eur. J. Clin. Invest.,Editorial,Final,Open Access,Scopus,2-s2.0-85079070836,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Long J.B., Ehrenfeld J.M.",57211477181;23099763100;,The Role of Augmented Intelligence (AI) in Detecting and Preventing the Spread of Novel Coronavirus,2020,Journal of Medical Systems,44,3,59,,,,2,10.1007/s10916-020-1536-6,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078951179&doi=10.1007%2fs10916-020-1536-6&partnerID=40&md5=a768614a7c7fc6ec71f1b322564e7f0a,"Children’s Healthcare of Atlanta at Egleston, Emory University, Atlanta, GA, United States; Advancing a Healthier Wisconsin Endowment, Medical College of Wisconsin, Milwaukee, WI, United States","Long, J.B., Children’s Healthcare of Atlanta at Egleston, Emory University, Atlanta, GA, United States; Ehrenfeld, J.M., Advancing a Healthier Wisconsin Endowment, Medical College of Wisconsin, Milwaukee, WI, United States",[No abstract available],,2019 novel coronavirus; augmented intelligence; Coronavirinae; Coronavirus infection; deep learning; diagnostic accuracy; Editorial; epidemic; health care system; human; infection control; information processing; nonhuman; public health; viral respiratory tract infection; virus detection; virus transmission,"Zhu, N., Zhang, D., Wang, W., A Novel Coronavirus from Patients with Pneumonia in China (2019) N Engl J Med, , Jan 24 2020; Mahase, E., China coronavirus: What do we know so far? (2020) BMJ, 368. , Jan 24, m308; Coronavirus Spreads to More Countries, All the Latest Updates: Al Jazeera Media Network, , https://www.aljazeera.com/news/2020/01/cloneofcloneofcloneofcloneofchina-battles-corona-200130230453300.html, Published 2020. Accessed January 31, 2020; Paules, C.I., Marston, H.D., Fauci, A.S., Coronavirus Infections-More Than Just the Common Cold (2020) JAMA, , Jan 23; Ross, C., In Coronavirus Response, AI is Becoming a Useful Tool in a Global Outbreak, Data Experts Say: STAT News, , https://www.statnews.com/2020/01/29/coronavirus-response-artificial-intelligence-becoming-useful/, Published 2020. Accessed January 31, 2020; The Disease Daily, , http://www.diseasedaily.org/about, n.d. Accessed January 31, 2020; Lazer, D., Kennedy, R., What We Can Learn from the Epic Failure of Google Flu Trends: WIRED, , https://www.wired.com/2015/10/can-learn-epic-failure-google-flu-trends/.Published2015, Accessed January 31, 2020; Brooks, L.C., Farrow, D.C., Hyun, S., Tibshirani, R.J., Rosenfeld, R., Nonmechanistic forecasts of seasonal influenza with iterative one-week-ahead distributions (2018) PLoS Comput Biol., 14 (6); Niller, E., (2020) An AI Epidemiologist Sent the First Warnings of the Wuhan Virus: WIRED, , https://www.wired.com/story/ai-epidemiologist-wuhan-public-health-warnings/, Published, Accessed January 31, 2020; Bogoch, I.I., Brady, O.J., Kraemer, M.U.G., German, M., Creatore, M.I., Kulkarni, M.A., Brownstein, J.S., Khan, K., Anticipating the international spread of Zika virus from Brazil (2016) Lancet., 387 (10016), pp. 335-336; Phelan, A.L., Katz, R., Gostin, L.O., The Novel Coronavirus Originating in Wuhan, China: JAMA, , https://jamanetwork.com/journals/jama/article-abstract/2760500, Published 2020. Accessed January 31, 2020","Ehrenfeld, J.M.; Advancing a Healthier Wisconsin Endowment, Medical College of WisconsinUnited States; email: jehrenfeld@mcw.edu",,Springer,1485598,,JMSYD,32020374,English,J. Med. Syst.,Editorial,Final,Open Access,Scopus,2-s2.0-85078951179,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Cheng V.C.C., Wong S.-C., To K.K.W., Ho P.L., Yuen K.-Y.",23670479400;56984917800;14323807300;7402211363;36078079100;,Preparedness and proactive infection control measures against the emerging novel coronavirus in China,2020,Journal of Hospital Infection,104,3,,254,255,,4,10.1016/j.jhin.2020.01.010,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078851496&doi=10.1016%2fj.jhin.2020.01.010&partnerID=40&md5=f3db556a08fe46cca2da7da016a474a4,"Department of Microbiology, Queen Mary Hospital, Hong Kong Special Administrative Region, China; Infection Control Team, Queen Mary Hospital, Hong Kong West Cluster, Hong Kong Special Administrative Region, China; Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region, China","Cheng, V.C.C., Department of Microbiology, Queen Mary Hospital, Hong Kong Special Administrative Region, China, Infection Control Team, Queen Mary Hospital, Hong Kong West Cluster, Hong Kong Special Administrative Region, China; Wong, S.-C., Infection Control Team, Queen Mary Hospital, Hong Kong West Cluster, Hong Kong Special Administrative Region, China; To, K.K.W., Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region, China; Ho, P.L., Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region, China; Yuen, K.-Y., Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region, China",[No abstract available],,China; coronavirus disease 2019; Coronavirus infection; diagnostic test; epidemic; health care planning; human; infection control; infection risk; influenza A (H5N1); Influenza A virus (H7N9); Letter; morbidity; mortality; risk factor; SARS-related coronavirus; virus genome; virus pneumonia; virus transmission,"The Centre for Health Protection closely monitors cluster of pneumonia cases on Mainland (2019), https://www.info.gov.hk/gia/general/201912/31/P2019123100667.htm, Press release. Available at:; Yuen, K.Y., Chan, P.K., Peiris, M., Tsang, D.N., Que, T.L., Shortridge, K.F., Clinical features and rapid viral diagnosis of human disease associated with avian influenza A H5N1 virus (1998) Lancet, 351, pp. 467-471; Cheng, V.C., Lau, S.K., Woo, P.C., Yuen, K.Y., Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection (2007) Clin Microbiol Rev, 20, pp. 660-694; Cheng, V.C., Tai, J.W., Wong, L.M., Chan, J.F., Li, I.W., To, K.K., Prevention of nosocomial transmission of swine-origin pandemic influenza virus A/H1N1 by infection control bundle (2010) J Hosp Infect, 74, pp. 271-277; Cheng, V.C., To, K.K., Tse, H., Hung, I.F., Yuen, K.Y., Two years after pandemic influenza A/2009/H1N1: what have we learned? (2012) Clin Microbiol Rev, 25, pp. 223-263; Cheng, V.C., Tai, J.W., Lee, W.M., Chan, W.M., Wong, S.C., Chen, J.H., Infection control preparedness for human infection with influenza A H7N9 in Hong Kong (2015) Infect Control Hosp Epidemiol, 36, pp. 87-92; Cheng, V.C., Lee, W.M., Sridhar, S., Ho, P.L., Yuen, K.Y., Prevention of nosocomial transmission of influenza A (H7N9) in Hong Kong (2015) J Hosp Infect, 90, pp. 355-356; Yip, C.C., Lam, C.S., Luk, H.K., Wong, E.Y., Lee, R.A., So, L.Y., A six-year descriptive epidemiological study of human coronavirus infections in hospitalized patients in Hong Kong (2016) Virol Sin, 31, pp. 41-48","Yuen, K.-Y.; Department of Microbiology, The University of Hong Kong, Hong Kong Special Administrative Region, China; email: kyyuen@hku.hk",,W.B. Saunders Ltd,1956701,,JHIND,31962139,English,J. Hosp. Infect.,Letter,Final,Open Access,Scopus,2-s2.0-85078851496,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Xu X., Chen P., Wang J., Feng J., Zhou H., Li X., Zhong W., Hao P.",57214590822;57214596017;8895947500;57214591459;57214595116;36717984800;35424990900;55603292000;,Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission,2020,Science China Life Sciences,63,3,,457,460,,26,10.1007/s11427-020-1637-5,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078718430&doi=10.1007%2fs11427-020-1637-5&partnerID=40&md5=e8a53449938d992a66d9b174812ea7ba,"Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Shanghai, 200031, China; Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, 200032, China; Key Laboratory of Systems Biomedicine, Ministry of Education, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, 200240, China; National Engineering Research Center for the Emergence Drugs, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China; The Joint Program in Infection and Immunity: Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, 510623, China; The Joint Program in Infection and Immunity: Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China","Xu, X., Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Shanghai, 200031, China; Chen, P., Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, 200032, China, The Joint Program in Infection and Immunity: Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, 510623, China; Wang, J., Key Laboratory of Systems Biomedicine, Ministry of Education, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, 200240, China; Feng, J., National Engineering Research Center for the Emergence Drugs, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China; Zhou, H., Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, 200032, China; Li, X., Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, 200032, China; Zhong, W., National Engineering Research Center for the Emergence Drugs, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, China; Hao, P., Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Shanghai, 200031, China, The Joint Program in Infection and Immunity: Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, 510623, China, The Joint Program in Infection and Immunity: Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China",[No abstract available],,"angiotensin converting enzyme 2; coronavirus spike glycoprotein; COVID-19; dipeptidyl carboxypeptidase; severe acute respiratory syndrome coronavirus 2; Alphacoronavirus; Betacoronavirus; binding site; chemical model; China; Coronavirus infection; epidemic; genetic variation; genetics; human; Middle East respiratory syndrome coronavirus; pathogenicity; phylogeny; physiology; protein conformation; SARS coronavirus; theoretical model; virus pneumonia; Alphacoronavirus; Betacoronavirus; Binding Sites; China; Coronavirus Infections; Disease Outbreaks; Genetic Variation; Humans; Middle East Respiratory Syndrome Coronavirus; Models, Chemical; Models, Theoretical; Peptidyl-Dipeptidase A; Phylogeny; Pneumonia, Viral; Protein Conformation; SARS Virus; Spike Glycoprotein, Coronavirus","(2020) 2019 Novel Coronavirus (2019-nCoV), Wuhan, China, , https://www.cdc.gov/coronavirus/novel-coronavirus-2019.html; Cotten, M., Watson, S.J., Kellam, P., Al-Rabeeah, A.A., Makhdoom, H.Q., Assiri, A., Al-Tawfiq, J.A., AlRabiah, F.A., Transmission and evolution of the Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive genomic study (2013) Lancet, 382, pp. 1993-2002. , PID: 24055451; Hu, B., Zeng, L.P., Yang, X.L., Ge, X.Y., Zhang, W., Li, B., Xie, J.Z., Wang, N., Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus (2017) PLoS Pathog, 13. , PID: 29190287; Li, F., Evidence for a common evolutionary origin of coronavirus spike protein receptor-binding subunits (2012) J Virol, 86, pp. 2856-2858. , COI: 1:CAS:528:DC%2BC38XivFSqs7k%3D, PID: 22205743; Li, F., Li, W., Farzan, M., Harrison, S.C., Structure of SARS coronavirus spike receptor-binding domain complexed with receptor (2005) Science, 309, pp. 1864-1868. , COI: 1:CAS:528:DC%2BD2MXpvFCisLw%3D, PID: 16166518; Maier, J.A., Martinez, C., Kasavajhala, K., Wickstrom, L., Hauser, K.E., Simmerling, C., ff14SB: improving the accuracy of protein side chain and backbone parameters from ff99SB (2015) J Chem Theor Comput, 11, pp. 3696-3713. , COI: 1:CAS:528:DC%2BC2MXhtFequ7rN; Normile, D., (2020) Mystery virus found in Wuhan resembles bat viruses but not SARS, Chinese scientist says, , https://www.sciencemag.org/news/2020/01/mystery-virus-found-wuhan-resembles-bat-viruses-not-sars-chinese-scientist-says; Raj, V.S., Mou, H., Smits, S.L., Dekkers, D.H.W., Müller, M.A., Dijkman, R., Muth, D., Fouchier, R.A.M., Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC (2013) Nature, 495, pp. 251-254. , COI: 1:CAS:528:DC%2BC3sXjvFensb8%3D, PID: 23486063; Schwede, T., Kopp, J., Guex, N., Peitsch, M.C., SWISSMODEL: an automated protein homology-modeling server (2003) Nucleic Acids Res, 31, pp. 3381-3385. , COI: 1:CAS:528:DC%2BD3sXltVWjsLg%3D, PID: 12824332; Shu, Y., McCauley, J., GISAID: Global initiative on sharing all influenza data—from vision to reality (2017) EuroSurveillance; (2020) Pneumonia of unknown cause in China, , https://www.who.int/csr/don/05-january-2020-pneumonia-of-unkown-cause-china/en/; Zhang, Y.Z., (2020) Initial genome release of novel coronavirus, , http://virological.org/t/initial-genome-release-of-novel-coronavirus/319?from=groupmessage","Hao, P.; Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Center for Biosafety Mega-Science, Chinese Academy of SciencesChina; email: phao@ips.ac.cn",,Science in China Press,16747305,,,32009228,English,Sci. China Life Sci.,Letter,Final,Open Access,Scopus,2-s2.0-85078718430,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Nkengasong J.,7005111716;,China’s response to a novel coronavirus stands in stark contrast to the 2002 SARS outbreak response,2020,Nature Medicine,26,3,,310,311,,5,10.1038/s41591-020-0771-1,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078490773&doi=10.1038%2fs41591-020-0771-1&partnerID=40&md5=4f72c51e5e0cbe37544c73708ea8f6a7,"Africa Centres for Disease Control and Prevention, Addis Ababa, Ethiopia","Nkengasong, J., Africa Centres for Disease Control and Prevention, Addis Ababa, Ethiopia",[No abstract available],,2019 novel coronavirus; behavior; China; communicable disease control; Coronavirinae; Coronavirus infection; diplomacy; drug response; environmental factor; epidemic; global health; government; health care policy; human; Note; priority journal; severe acute respiratory syndrome; travel; treatment response,"Mukherjee, S., (2017) Indian J. Dermatol., 62, pp. 459-467. , PID: 28979007; Novel Coronavirus – China, , https://www.who.int/csr/don/12-january-2020-novel-coronavirus-china/en/, 12 January 2020; (2020) Wuhan Population 2020, , http://worldpopulationreview.com/world-cities/wuhan-population/; Juan, D., (2020), https://www.chinadaily.com.cn/a/202001/01/WS5e0c6a49a310cf3e35581e30.html, China Daily; Cohen, J., Normile, D., (2020) Science, 367, pp. 234-235. , COI: 1:CAS:528:DC%2BB3cXhs12lurg%3D; Smith, R.D., (2006) Soc. Sci. Med., 63, pp. 3113-3123; Lee, J.-W., McKibbin, W.J., (2004) Learning from SARS: Preparing for the Next Disease Outbreak: Workshop Summary, , https://www.ncbi.nlm.nih.gov/books/NBK92473/, Knobler, S. et al, National Academies Press; (2004) Timeline of an Outbreak, , https://www.webmd.com/lung/news/20030411/sars-timeline-of-outbreak#1; Li, C., (2016) Am. J. Public Health, 106, pp. 2093-2102; https://www.cnbc.com/2020/01/20/coronavirus-china-confirms-new-cases-as-virus-spreads-to-new-cities.html, 19 January 2020; https://www.todayonline.com/world/thailand-finds-second-case-new-chinese-virussays-no-outbreak-1, (accessed 17 Jan 2020); Wee, S.-L., (2020) New York Times, , https://www.nytimes.com/2020/01/15/world/asia/coronavirus-japan-china.html, 15 January; https://www.mhlw.go.jp/stf/newpage_08906.html, accessed 16 Jan 2020; Cheung, E., Ho-Him, C., https://www.scmp.com/news/hong-kong/health-environment/article/3045622/wuhan-pneumonia-six-more-cases-hong-kong-take, South China Morning Post, 10 January 2020; Lai, L., The Straits Times, , https://www.straitstimes.com/singapore/3rd-suspected-wuhan-virus-case-detected-in-singapore-man-isolated-as-precaution, 16 January 2020; Levine, J., New York Post, , https://nypost.com/2020/01/18/deadly-chinese-virus-may-have-infected-over-1700-people-study-claims/, 18 January 2020; (2003), https://edition.cnn.com/2003/HEALTH/04/09/sars.africa/, 9 April; Zhou, Y., (2019) Quartz Africa, , https://qz.com/africa/1675287/china-to-africa-flights-jumped-630-in-the-past-nine-years/, 28 July","Nkengasong, J.; Africa Centres for Disease Control and PreventionEthiopia; email: nkengasongj@africa-union.org",,Nature Research,10788956,,NAMEF,31988464,English,Nat. Med.,Note,Final,Open Access,Scopus,2-s2.0-85078490773,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Li Y.-T., Chen T.-C., Lin S.-Y., Mase M., Murakami S., Horimoto T., Chen H.-W.",56127219700;57212623434;35774421800;56218981300;36947717400;7004547083;14059700300;,Emerging lethal infectious bronchitis coronavirus variants with multiorgan tropism,2020,Transboundary and Emerging Diseases,67,2,,884,893,,,10.1111/tbed.13412,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85075231465&doi=10.1111%2ftbed.13412&partnerID=40&md5=a43fe5d48086317b84434fdf54b17e9c,"Department of Veterinary Medicine, National Taiwan University, Taipei, Taiwan; Division of Viral Disease and Epidemiology, National Institute of Animal Health, National Agriculture and Food Research Organization, Ibaraki, Japan; Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan","Li, Y.-T., Department of Veterinary Medicine, National Taiwan University, Taipei, Taiwan; Chen, T.-C., Department of Veterinary Medicine, National Taiwan University, Taipei, Taiwan; Lin, S.-Y., Department of Veterinary Medicine, National Taiwan University, Taipei, Taiwan; Mase, M., Division of Viral Disease and Epidemiology, National Institute of Animal Health, National Agriculture and Food Research Organization, Ibaraki, Japan; Murakami, S., Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan; Horimoto, T., Department of Veterinary Microbiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan; Chen, H.-W., Department of Veterinary Medicine, National Taiwan University, Taipei, Taiwan","Infectious bronchitis virus (IBV) causes respiratory diseases in chickens and poses an economic threat to the poultry industry worldwide. Despite vaccine use, there have been field outbreaks of IBV in Taiwan. This study aimed to characterize the emerging IBV variants circulating in Taiwan. The analysis of the structural protein genes showed that these variants emerged through frequent recombination events among Taiwan strains, China strains, Japan strains and vaccine strains. Cross-neutralization tests revealed that two of the variants exhibited novel serotypes. Clinicopathological assessment showed that two of the variants caused high fatality rates of 67% and 20% in one-day-old SPF chicks, and all the variants possessed multiorgan tropisms, including trachea, proventriculus and urogenital tissues. Furthermore, the commercial live-attenuated Mass-type vaccine conferred poor protection against these variants. This study identified novel genotypes, serotypes and pathotypes of emerging IBV variants circulating in Taiwan. There is an urgent need for effective countermeasures against these variant strains. © 2019 Blackwell Verlag GmbH",infectious bronchitis virus; multiorgan tropism; pathotype; recombinant variants; serotype,nucleocapsid protein; structural protein; virus antibody; virus RNA; virus vaccine; animal experiment; animal model; animal tissue; antibody production; antigenic variation; antigenicity; Article; avian infectious bronchitis; Avian infectious bronchitis virus; broiler; controlled study; enzyme linked immunosorbent assay; female; gene sequence; genotype; immunohistochemistry; kidney; lethality; mortality rate; neighbor joining method; nonhuman; organ; phenotype; phylogeny; proventriculus; reverse transcription polymerase chain reaction; RNA extraction; sequence homology; serotype; trachea; urogenital system; vaccination; viral tropism; virus detection; virus neutralization; virus recombinant; virus shedding; virus titration; virus transmission; virus virulence,"Archetti, I., Horsfall, F.L., Jr., Persistent antigenic variation of influenza A viruses after incomplete neutralization in ovo with heterologous immune serum (1950) Journal of Experimental Medicine, 92, pp. 441-462. , https://doi.org/10.1084/jem.92.5.441; 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Chen, Y., Jiang, L., Zhao, W., Liu, L., Zhao, Y., Shao, Y., Liu, S., Identification and molecular characterization of a novel serotype infectious bronchitis virus (GI-28) in China (2017) Veterinary Microbiology, 198, pp. 108-115. , https://doi.org/10.1016/j.vetmic.2016.12.017; Cook, J.K., Jackwood, M., Jones, R.C., The long view: 40 years of infectious bronchitis research (2012) Avian Pathology, 41, pp. 239-250. , https://doi.org/10.1080/03079457.2012.680432; Gao, M., Wang, Q., Zhao, W., Chen, Y., Zhang, T., Han, Z., Liu, S., Serotype, antigenicity, and pathogenicity of a naturally recombinant TW I genotype infectious bronchitis coronavirus in China (2016) Veterinary Microbiology, 191, pp. 1-8. , https://doi.org/10.1016/j.vetmic.2016.05.018; Hewson, K.A., Noormohammadi, A.H., Devlin, J.M., Browning, G.F., Schultz, B.K., Ignjatovic, J., Evaluation of a novel strain of infectious bronchitis virus emerged as a result of spike gene recombination between two highly diverged parent strains (2014) Avian Pathology, 43, pp. 249-257. , https://doi.org/10.1080/03079457.2014.914624; 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Lin, K.Y., Wang, H.C., Wang, C.H., Protective effect of vaccination in chicks with local infectious bronchitis viruses against field virus challenge (2005) Journal of Microbiology, Immunology and Infection, 38, pp. 25-30; Lin, S.Y., Chen, H.W., Infectious bronchitis virus variants: Molecular analysis and pathogenicity investigation (2017) International Journal of Molecular Sciences, 18, p. 2030. , https://doi.org/10.3390/ijms18102030; Lin, S.Y., Li, Y.T., Chen, Y.T., Chen, T.C., Hu, C.J., Chen, H.W., Identification of an infectious bronchitis coronavirus strain exhibiting a classical genotype but altered antigenicity, pathogenicity, and innate immunity profile (2016) Scientific Reports, 6, p. 37725. , https://doi.org/10.1038/srep37725; Ma, H., Shao, Y., Sun, C., Han, Z., Liu, X., Guo, H., Liu, S., Genetic diversity of avian infectious bronchitis coronavirus in recent years in China (2012) Avian Diseases, 56, pp. 15-28. , https://doi.org/10.1637/9804-052011-Reg.1; Martin, D.P., Murrell, B., Golden, M., Khoosal, A., Muhire, B., RDP4: Detection and analysis of recombination patterns in virus genomes (2015) Virus Evolution, 1, p. vev003. , https://doi.org/10.1093/ve/vev003; Mase, M., Tsukamoto, K., Imai, K., Yamaguchi, S., Phylogenetic analysis of avian infectious bronchitis virus strains isolated in Japan (2004) Archives of Virology, 149, pp. 2069-2078. , https://doi.org/10.1007/s00705-004-0369-9; Reed, L.J., Muench, H., A simple method of estimating fifty per cent endpoints (1938) The American Journal of Hygiene, 27, pp. 493-497; Shieh, H.K., Shien, J.H., Chou, H.Y., Shimizu, Y., Chen, J.N., Chang, P.C., Complete nucleotide sequences of S1 and N genes of infectious bronchitis virus isolated in Japan and Taiwan (2004) Journal of Veterinary Medical Science, 66, pp. 555-558. , https://doi.org/10.1292/jvms.66.555; Sjaak de Wit, J.J., Cook, J.K., van der Heijden, H.M., Infectious bronchitis virus variants: A review of the history, current situation and control measures (2011) Avian Pathology, 40, pp. 223-235. , https://doi.org/10.1080/03079457.2011.566260; Tamura, K., Dudley, J., Nei, M., Kumar, S., MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0 (2007) Molecular Biology and Evolution, 24, pp. 1596-1599. , https://doi.org/10.1093/molbev/msm092; Tsai, C.T., Tsai, H.F., Wang, C.H., Detection of infectious bronchitis virus strains similar to Japan in Taiwan (2016) Journal of Veterinary Medical Science, 78, pp. 867-871. , https://doi.org/10.1292/jvms.15-0609; Valastro, V., Holmes, E.C., Britton, P., Fusaro, A., Jackwood, M.W., Cattoli, G., Monne, I., S1 gene-based phylogeny of infectious bronchitis virus: An attempt to harmonize virus classification (2016) Infection, Genetics and Evolution, 39, pp. 349-364. , https://doi.org/10.1016/j.meegid.2016.02.015; Wang, C.H., Hsieh, M.C., Chang, P.C., Isolation, pathogenicity, and H120 protection efficacy of infectious bronchitis viruses isolated in Taiwan (1996) Avian Diseases, 40, pp. 620-625. , https://doi.org/10.2307/1592273; Wang, C.H., Huang, Y.C., Relationship between serotypes and genotypes based on the hypervariable region of the S1 gene of infectious bronchitis virus (2000) Archives of Virology, 145, pp. 291-300. , https://doi.org/10.1007/s007050050024; Wang, C.H., Tsai, C.T., Genetic grouping for the isolates of avian infectious bronchitis virus in Taiwan (1996) Archives of Virology, 141, pp. 1677-1688. , https://doi.org/10.1007/BF01718291; Xu, G., Cheng, J.L., Ma, S.H., Jia, W.F., Yan, S.H., Zhang, G.Z., Pathogenicity differences between a newly emerged TW-like strain and a prevalent QX-like strain of infectious bronchitis virus (2018) Veterinary Microbiology, 227, pp. 20-28. , https://doi.org/10.1016/j.vetmic.2018.10.019; Xu, G., Liu, X.Y., Zhao, Y., Chen, Y., Zhao, J., Zhang, G.Z., Characterization and analysis of an infectious bronchitis virus strain isolated from southern China in 2013 (2016) Virology Journal, 13, p. 40. , https://doi.org/10.1186/s12985-016-0497-3; Zanaty, A., Naguib, M.M., El-Husseiny, M.H., Mady, W., Hagag, N., Arafa, A.S., The sequence of the full spike S1 glycoprotein of infectious bronchitis virus circulating in Egypt reveals evidence of intra-genotypic recombination (2016) Archives of Virology, 161, pp. 3583-3587. , https://doi.org/10.1007/s00705-016-3042-1; Zhong, Q., Hu, Y.X., Jin, J.H., Zhao, Y., Zhao, J., Zhang, G.Z., Pathogenicity of virulent infectious bronchitis virus isolate YN on hen ovary and oviduct (2016) Veterinary Microbiology, 193, pp. 100-105. , https://doi.org/10.1016/j.vetmic.2016.08.017; Zhou, H., Zhang, M., Tian, X., Shao, H., Qian, K., Ye, J., Qin, A., Identification of a novel recombinant virulent avian infectious bronchitis virus (2017) Veterinary Microbiology, 199, pp. 120-127. , https://doi.org/10.1016/j.vetmic.2016.12.038","Chen, H.-W.; Department of Veterinary Medicine, National Taiwan UniversityTaiwan; email: winnichen@ntu.edu.tw",,Blackwell Publishing Ltd,18651674,,,31682070,English,Transboundary Emer. Dis.,Article,Final,Open Access,Scopus,2-s2.0-85075231465,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Chen Z., DU L.-Z., Fu J.-F., Shu Q., Chen Z.-M., Shi L.-P., Wang W., Chen S.-H., Ma X.-L., Ye S., Sun W., Chen M.-Y., Zhu H.-H., Huang G.-L., Luo F.-X.",57211811691;7201905885;57215892917;57210698907;57215894784;57215892821;57215895575;57215894453;36114416400;57215893438;55726586500;57215895418;57215892781;57215893370;57215892822;,Emergency plan for inter-hospital transfer of newborns with SARS-CoV-2 infection,2020,Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics,22,3,,226,230,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082261696&partnerID=40&md5=bf690a5949313febafed953446da22dd,"National Clinical Research Center for Child Health/National Children's Regional Medical Center/Children's Hospital, Zhejiang University School of Medicine, Hangzhou, 310052, China","Chen, Z., National Clinical Research Center for Child Health/National Children's Regional Medical Center/Children's Hospital, Zhejiang University School of Medicine, Hangzhou, 310052, China; DU, L.-Z.; Fu, J.-F.; Shu, Q.; Chen, Z.-M.; Shi, L.-P.; Wang, W.; Chen, S.-H.; Ma, X.-L.; Ye, S.; Sun, W.; Chen, M.-Y.; Zhu, H.-H.; Huang, G.-L.; Luo, F.-X.","Since December 2019, the outbreak of coronavirus disease (COVID-19) has become the most serious public health issue. As the special population with immature immune function, newborns with COVID-19 have been reported. Newborns with suspected or confirmed COVID-19 should be transferred to designated hospitals for isolation treatment. An emergency transfer response plan for newborns with COVID-19 has been worked out. This plan puts forward the indications for neonatal COVID-19 transfer, organization management, protection strategies for medical staff, work procedures, and disinfection methods for transfer equipment, in order to provide guidance and suggestions for the inter-hospital transfer of suspected or confirmed neonatal COVID-19.",,"Betacoronavirus; Coronavirus infection; hospital; human; newborn; virus pneumonia; Betacoronavirus; Coronavirus Infections; Hospitals; Humans; Infant, Newborn; Pneumonia, Viral",,,,NLM (Medline),10088830,,,32204758,Chinese,Zhongguo Dang Dai Er Ke Za Zhi,Article,Final,,Scopus,2-s2.0-85082261696,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhang G.-X., Zhang A.-M., Huang L., Cheng L.-Y., Liu Z.-X., Peng X.-L., Wang H.-W.",57215894481;57215893414;57215893424;57215893410;57215893127;57215894523;57215893832;,Twin girls infected with SARS-CoV-2,2020,Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics,22,3,,221,225,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082259486&partnerID=40&md5=da4d810ee4fd076b67999e54c19d0144,"Department of Pediatrics, First People's Hospital of Xiangtan, Xiangtan, Hunan 411101, China","Zhang, G.-X., Department of Pediatrics, First People's Hospital of Xiangtan, Xiangtan, Hunan 411101, China; Zhang, A.-M.; Huang, L.; Cheng, L.-Y.; Liu, Z.-X.; Peng, X.-L.; Wang, H.-W.","This article reports the diagnosis and treatment of twin girls who were diagnosed with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in Hunan Province, China. The twin girls, aged 1 year and 2 months, were admitted on January 29, 2020 due to fever for one day and cough and sneezing for two days respectively. Both recovered after symptomatic treatment. The two girls had mild symptoms and rapid recovery, suggesting that children with SARS-CoV-2 infection may be mild and have a good prognosis. There were differences in the clinical symptoms and imaging findings between the twin girls, suggesting that SARS-CoV-2 infection has diverse clinical features in children.",,"Betacoronavirus; case report; China; Coronavirus infection; female; human; infant; twin study; virus pneumonia; Betacoronavirus; China; Coronavirus Infections; Female; Humans; Infant; Pneumonia, Viral; Twin Studies as Topic",,,,NLM (Medline),10088830,,,32204757,Chinese,Zhongguo Dang Dai Er Ke Za Zhi,Article,Final,,Scopus,2-s2.0-85082259486,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wang J., Wang D., Chen G.-C., Tao X.-W., Zeng L.-K.",57215894813;57215894457;57215894650;57215893457;57215895461;,SARS-CoV-2 infection with gastrointestinal symptoms as the first manifestation in a neonate,2020,Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics,22,3,,211,214,,1,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082251762&partnerID=40&md5=5f9d93edd215826564f237284ac71ddb,"Wuhan Children's Hospital/Wuhan Maternal and Child Healthcare Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430016, China","Wang, J., Wuhan Children's Hospital/Wuhan Maternal and Child Healthcare Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430016, China; Wang, D.; Chen, G.-C.; Tao, X.-W.; Zeng, L.-K.","Since December 2019, the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has occurred in Wuhan, Hubei Province, China. The infected cases were noted mostly in adults, but rarely reported in children, especially neonates. Most children with SARS-CoV-2 infection present mainly with respiratory symptoms, but less commonly with gastrointestinal symptoms, and tend to have mild clinical symptoms. A neonate with SARS-CoV-2 infection, who had vomiting and milk refusal as the first symptom, was recently admitted to Wuhan Children's Hospital. After two weeks of treatment, the patient recovered gradually and was discharged. Here, this case is reported to improve the understanding of SARS-CoV-2 infection in neonates.",,"Betacoronavirus; case report; China; Coronavirus infection; human; newborn; virus pneumonia; Betacoronavirus; China; Coronavirus Infections; Humans; Infant, Newborn; Pneumonia, Viral",,,,NLM (Medline),10088830,,,32204755,Chinese,Zhongguo Dang Dai Er Ke Za Zhi,Article,Final,,Scopus,2-s2.0-85082251762,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Lake M.A.,57188547974;,What we know so far: COVID-19 current clinical knowledge and research,2020,"Clinical medicine (London, England)",20,2,,124,127,,,10.7861/clinmed.2019-coron,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082095408&doi=10.7861%2fclinmed.2019-coron&partnerID=40&md5=13fd528f58b3022da933826e4e91502a,"University of Cambridge, Cambridge, United Kingdom","Lake, M.A., University of Cambridge, Cambridge, United Kingdom","In December 2019, health authorities in Wuhan, China, identified a cluster of pneumonia cases of unknown aetiology linked to the city's South China Seafood Market. Subsequent investigations revealed a novel coronavirus, SARS-CoV-2, as the causative agent now at the heart of a major outbreak. The rising case numbers have been accompanied by unprecedented public health action, including the wholesale isolation of Wuhan. Alongside this has been a robust scientific response, including early publication of the pathogen genome, and rapid development of highly specific diagnostics. This article will review the new knowledge of SARS-CoV-2 COVID-19 acute respiratory disease, and summarise its clinical features. © Royal College of Physicians 2020. All rights reserved.",2019-nCoV; coronavirus; respiratory tract infection; SARS-CoV-2; Wuhan,"COVID-19; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; Coronavirus infection; epidemic; health survey; human; palliative therapy; public health; severe acute respiratory syndrome; virus pneumonia; Betacoronavirus; Coronavirus Infections; Disease Outbreaks; Humans; Palliative Care; Pneumonia, Viral; Public Health; Public Health Surveillance; Severe Acute Respiratory Syndrome",,,,NLM (Medline),14734893,,,32139372,English,Clin Med (Lond),Review,Final,Open Access,Scopus,2-s2.0-85082095408,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Medical Association of Chinese People's Liberation Army, Editorial Committee of Chinese Journal of Contemporary Pediatrics, Preparatory Group of Pediatric Disaster, Pediatric Society, Chinese Medical Association",,Response plan in the neonatal intensive care unit during epidemic of SARS-CoV-2 infection (2nd Edition),2020,Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics,22,3,,205,210,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082283260&partnerID=40&md5=67c5c69965f6418e9c3ce8fa34413071,,"Medical Association of Chinese People's Liberation Army; Editorial Committee of Chinese Journal of Contemporary Pediatrics; Preparatory Group of Pediatric Disaster, Pediatric Society, Chinese Medical Association","Since December 2019, an outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has spread from China to other countries. In order to effectively respond to possible neonatal SARS-CoV-2 infection, neonatologists from the Medical Association of Chinese People's Liberation Army and the Editorial Committee of Chinese Journal of Contemporary Pediatrics proposed the response plan in the neonatal intensive care unit during epidemic of SARS-CoV-2 infection (1st edition) at the end of January of 2020. Based on the further knowledge and experience on SARS-CoV-2 infection, the neonatologists updated the plan according to the current evidence, so as to provide a better guide for clinical medical staff to deal with the SARS-CoV-2 infection in the NICU.",,"Betacoronavirus; China; Coronavirus infection; epidemic; human; neonatal intensive care unit; newborn; virus pneumonia; Betacoronavirus; China; Coronavirus Infections; Epidemics; Humans; Infant, Newborn; Intensive Care Units, Neonatal; Pneumonia, Viral",,,,NLM (Medline),10088830,,,32204754,Chinese,Zhongguo Dang Dai Er Ke Za Zhi,Article,Final,,Scopus,2-s2.0-85082283260,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Prompetchara E., Ketloy C., Palaga T.",55653652000;24366730100;6506606517;,Immune responses in COVID-19 and potential vaccines: Lessons learned from SARS and MERS epidemic,2020,Asian Pacific journal of allergy and immunology,38,1,,1,9,,2,10.12932/AP-200220-0772,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082147518&doi=10.12932%2fAP-200220-0772&partnerID=40&md5=2fa11c2f7f52b35ae098a6a195497917,"Center of Excellence in Vaccine Research and Development (Chula Vaccine Research Center Chula VRC), Faculty of Medicine, Chulalongkorn UniversityBangkok 10330, Thailand; Vaccines and Therapeutic Proteins Research Group, Special Task Force for Activating Research (STAR), Chulalongkorn UniversityBangkok 10330, Thailand; Department of Microbiology, Faculty of Science, Chulalongkorn UniversityBangkok 10330, Thailand; Center of Excellence in Immunology and Immune-mediated Diseases, Chulalongkorn UniversityBangkok 10330, Thailand","Prompetchara, E., Center of Excellence in Vaccine Research and Development (Chula Vaccine Research Center Chula VRC), Faculty of Medicine, Chulalongkorn UniversityBangkok 10330, Thailand, Vaccines and Therapeutic Proteins Research Group, Special Task Force for Activating Research (STAR), Chulalongkorn UniversityBangkok 10330, Thailand; Ketloy, C., Center of Excellence in Vaccine Research and Development (Chula Vaccine Research Center Chula VRC), Faculty of Medicine, Chulalongkorn UniversityBangkok 10330, Thailand; Palaga, T., Department of Microbiology, Faculty of Science, Chulalongkorn UniversityBangkok 10330, Thailand, Center of Excellence in Immunology and Immune-mediated Diseases, Chulalongkorn UniversityBangkok 10330, Thailand","As the world is witnessing the epidemic of COVID-19, a disease caused by a novel coronavirus, SARS-CoV-2, emerging genetics and clinical evidences suggest a similar path to those of SARS and MERS. The rapid genomic sequencing and open access data, together with advanced vaccine technology, are expected to give us more knowledge on the pathogen itself, including the host immune response as well as the plan for therapeutic vaccines in the near future. This review aims to provide a comparative view among SARS-CoV, MERS-CoV and the newly epidemic SARS-CoV-2, in the hope to gain a better understanding of the host-pathogen interaction, host immune responses, and the pathogen immune evasion strategies. This predictive view may help in designing an immune intervention or preventive vaccine for COVID-19 in the near future.",,"COVID-19; severe acute respiratory syndrome coronavirus 2; virus vaccine; adaptive immunity; Betacoronavirus; Coronavirus infection; epidemic; host pathogen interaction; human; immune evasion; immunology; innate immunity; Middle East respiratory syndrome coronavirus; SARS coronavirus; severe acute respiratory syndrome; virus pneumonia; Adaptive Immunity; Betacoronavirus; Coronavirus Infections; Epidemics; Host-Pathogen Interactions; Humans; Immune Evasion; Immunity, Innate; Middle East Respiratory Syndrome Coronavirus; Pneumonia, Viral; SARS Virus; Severe Acute Respiratory Syndrome; Viral Vaccines",,,,NLM (Medline),0125877X,,,32105090,English,Asian Pac. J. Allergy Immunol.,Review,Final,Open Access,Scopus,2-s2.0-85082147518,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Chen J.,36438192700;,Pathogenicity and transmissibility of 2019-nCoV—A quick overview and comparison with other emerging viruses,2020,Microbes and Infection,22,2,,69,71,,5,10.1016/j.micinf.2020.01.004,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079708329&doi=10.1016%2fj.micinf.2020.01.004&partnerID=40&md5=34ea4396498ffd73d4a22483ce6edb21,"Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China","Chen, J., Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China","A zoonotic coronavirus, tentatively labeled as 2019-nCoV by the World Health Organization (WHO), has been identified as the causative agent of the viral pneumonia outbreak in Wuhan, China, at the end of 2019. Although 2019-nCoV can cause a severe respiratory illness like SARS and MERS, evidence from clinics suggested that 2019-nCoV is generally less pathogenic than SARS-CoV, and much less than MERS-CoV. The transmissibility of 2019-nCoV is still debated and needs to be further assessed. To avoid the 2019-nCoV outbreak turning into an epidemic or even a pandemic and to minimize the mortality rate, China activated emergency response procedures, but much remains to be learned about the features of the virus to refine the risk assessment and response. Here, the current knowledge in 2019-nCoV pathogenicity and transmissibility is summarized in comparison with several commonly known emerging viruses, and information urgently needed for a better control of the disease is highlighted. © 2020 The Author(s)",ACE2; Basic reproduction number (R0); Case fatality rate; Novel coronavirus infection; SARS,"2019 novel coronavirus; Article; China; Coronavirinae; Coronavirus infection; human; Middle East respiratory syndrome coronavirus; mortality rate; nonhuman; priority journal; SARS coronavirus; virus pneumonia; virus transmission; virus virulence; basic reproduction number; Betacoronavirus; pandemic; pathogenicity; virology; virulence; COVID-19; severe acute respiratory syndrome coronavirus 2; Basic Reproduction Number; Betacoronavirus; Coronavirus Infections; Humans; Pandemics; Pneumonia, Viral; Virulence","WHO, Statement on the meeting of the International Health Regulations (2005) Emergency Committee regarding the outbreak of novel coronavirus (2019-nCoV) (2020), posting date [Online.]; Wang, C., Horby, P.W., Hayden, F.G., Gao, G.F., A novel coronavirus outbreak of global health concern (2020) Lancet, , [in press]; Perlman, S., Another decade, another coronavirus (2020) N Engl J Med, , [in press]; Cui, J., Li, F., Shi, Z.L., Origin and evolution of pathogenic coronaviruses (2019) Nat Rev Microbiol, 17, pp. 181-192; de Wit, E., van Doremalen, N., Falzarano, D., Munster, V.J., SARS and MERS: recent insights into emerging coronaviruses (2016) Nat Rev Microbiol, 14, pp. 523-534; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, , [in press]; Chan, J.F.-W., Kok, K.-H., Zhu, Z., Chu, H., To, K.K.-W., Yuan, S., Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from patients with acute respiratory disease in Wuhan, Hubei, China (2020) Emerg Microb Infect, , [in press]; Zhou, P., Yang, X.-L., Wang, X.-G., Hu, B., Zhang, L., Zhang, W., Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin (2020) bioRxiv, , [in press]; Chan, J.F.-W., Yuan, S., Kok, K.-H., To, K.K.-W., Chu, H., Yang, J., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, , [in press]; Zhao, S., Ran, J., Musa, S.S., Yang, G., Lou, Y., Gao, D., Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: a data-driven analysis in the early phase of the outbreak (2020) bioRxiv, , [in press]; Bauch, C.T., Oraby, T., Assessing the pandemic potential of MERS-CoV (2013) Lancet, 382, pp. 662-664; Read, J.M., Bridgen, J.R., Cummings, D.A., Ho, A., Jewell, C.P., Novel coronavirus 2019-nCoV: early estimation of epidemiological parameters and epidemic predictions (2020) medRxiv, , [in press]; Delamater, P.L., Street, E.J., Leslie, T.F., Yang, Y.T., Jacobsen, K.H., Complexity of the basic reproduction number (R0) (2019) Emerg Infect Dis, 25, pp. 1-4; Shen, M., Peng, Z., Xiao, Y., Zhang, L., Modelling the epidemic trend of the 2019 novel coronavirus outbreak in China (2020) bioRxiv, , [in press]; Hamming, I., Timens, W., Bulthuis, M.L., Lely, A.T., Navis, G., van Goor, H., Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis (2004) J Pathol, 203, pp. 631-637; Munster, V.J., Koopmans, M., van Doremalen, N., van Riel, D., de Wit, E., A novel coronavirus emerging in China — key questions for impact assessment (2020) N Engl J Med, , [in press]; van den Driessche, P., Reproduction numbers of infectious disease models (2017) Infect Dis Model, 2, pp. 288-303; Jiang, S., Du, L., Shi, Z., An emerging coronavirus causing pneumonia outbreak in Wuhan, China: calling for developing therapeutic and prophylactic strategies (2020) Emerg Microb Infect, , [in press]; Yu, F., Ojcis, D., Pan, C., Jiang, S., Measures for diagnosing and treating infections by a novel coronavirus responsible for a pneumonia outbreak originating in Wuhan, China (2020) Microb Infect, 22, pp. 74-79",,,Elsevier Masson SAS,12864579,,MCINF,32032682,English,Microbes Infect.,Article,Final,Open Access,Scopus,2-s2.0-85079708329,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Ahmadzadeh J., Mobaraki K., Mousavi S.J., Aghazadeh-Attari J., Mirza-Aghazadeh-Attari M., Mohebbi I.",36573331500;55853618500;57213828585;36643305500;57194018318;23019266500;,The risk factors associated with MERS-CoV patient fatality: A global survey,2020,Diagnostic Microbiology and Infectious Disease,96,3,114876,,,,1,10.1016/j.diagmicrobio.2019.114876,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078036304&doi=10.1016%2fj.diagmicrobio.2019.114876&partnerID=40&md5=a5e0a1351f4f34a7a8bb7aac68062630,"Social Determinants of Health Research Center, Urmia University of Medical Sciences, Urmia, Iran; Department of Infectious Diseases, Urmia University of Medical Sciences, Urmia, Iran; Medical philosophy and history research center, Tabriz University of Medical Sciences, Tabriz, Iran","Ahmadzadeh, J., Social Determinants of Health Research Center, Urmia University of Medical Sciences, Urmia, Iran; Mobaraki, K., Social Determinants of Health Research Center, Urmia University of Medical Sciences, Urmia, Iran; Mousavi, S.J., Department of Infectious Diseases, Urmia University of Medical Sciences, Urmia, Iran; Aghazadeh-Attari, J., Social Determinants of Health Research Center, Urmia University of Medical Sciences, Urmia, Iran; Mirza-Aghazadeh-Attari, M., Medical philosophy and history research center, Tabriz University of Medical Sciences, Tabriz, Iran; Mohebbi, I., Social Determinants of Health Research Center, Urmia University of Medical Sciences, Urmia, Iran","Risk factors associated with Middle East respiratory syndrome coronavirus (MERS-CoV) infection outcome were established by analyses of WHO data from September 23, 2012 to 18 June 2018. Of the 2220 reported cases, 1408 cases, including 451 MERS-CoV deaths, were analyzed. The case fatality rate was 32% (95% CI: 29.4–34.5). Compared to MERS patients ≤30 years old, those with >30 years had the adjusted odds ratio estimate for death of 2.38 [95% CI: 1.75–3.22]. This index was 1.43 [95% CI: 1.06–1.92] for Saudi patients in comparison to non-Saudi; 1.76 [95% CI: 1.39–2.22] for patient with comorbidity in comparison to those without comorbidity; 0.58 [95% CI: 0.44–0.75] for those who had close contact to a camel in the past 14 days and 0.42 [95% CI: 0.31–0.57] for patients with >14 days with onset of signs and hospital admission compared to patients with ≤14 days. © 2019",Case fatality rate; Emerging infectious disease; Epidemiology; Middle East respiratory syndrome coronavirus,adult; Article; case fatality rate; cause of death; comorbidity; controlled study; diabetes mellitus; disease severity; female; hospital admission; human; hypertension; incidence; ischemic heart disease; major clinical study; male; Middle East respiratory syndrome; morbidity; mortality rate; population research; priority journal; risk factor; Saudi Arabia,"Cowling, B.J., Park, M., Fang, V.J., Wu, P., Leung, G.M., Wu, J.T., Preliminary epidemiologic assessment of MERS-CoV outbreak in South Korea, May–June 2015 (2015) Euro surveillance: bulletin Europeen sur les maladies transmissibles – European communicable disease bulletin, 20 (25); Alamoudi, R.J., Azhar, L.E., Alamoudi, D.H., Alamoudi, D.H., Tolah, A.M., Alhabbab, R.Y., No molecular evidence of MERS-CoV circulation in Jeddah, Saudi Arabia between 2010–2012: a single-center retrospective study (2018) The Journal of Infection in Developing Countries, 12 (5), pp. 390-393; Alghamdi, I.G., Hussain, I.I., Almalki, S.S., Alghamdi, M.S., Alghamdi, M.M., El-Sheemy, M.A., The pattern of Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive epidemiological analysis of data from the Saudi Ministry of Health (2014) International journal of general medicine, 7, p. 417; Alraddadi, B.M., Al-Salmi, H.S., Jacobs-Slifka, K., Slayton, R.B., Estivariz, C.F., Geller, A.I., Risk factors for Middle East respiratory syndrome coronavirus infection among healthcare personnel (2016) Emerg Infect Dis, 22 (11), p. 1915; Alshahrani, M.S., Sindi, A., Alshamsi, F., Al-Omari, A., El Tahan, M., Alahmadi, B., Extracorporeal membrane oxygenation for severe Middle East respiratory syndrome coronavirus (2018) Ann Intensive Care, 8 (1), p. 3; Alzeer, A.H., Respiratory tract infection during hajj (2009) Annals of thoracic medicine, 4 (2), p. 50; Assiri, A., McGeer, A., Perl, T.M., Price, C.S., Al Rabeeah, A.A., Cummings, D.A., Hospital outbreak of Middle East respiratory syndrome coronavirus (2013) New England Journal of Medicine, 369 (5), pp. 407-416; Castaño-Rodriguez, C., Honrubia, J.M., Gutiérrez-Álvarez, J., DeDiego, M.L., Nieto-Torres, J.L., Jimenez-Guardeño, J.M., Role of severe acute respiratory syndrome coronavirus Viroporins E, 3a, and 8a in replication and pathogenesis. MBio 2018;9(3):e02325–17; Cong, Y., Hart, B.J., Gross, R., Zhou, H., Frieman, M., Bollinger, L., MERS-CoV pathogenesis and antiviral efficacy of licensed drugs in human monocyte-derived antigen-presenting cells (2018) PloS one, 13 (3); Conzade, R., Grant, R., Malik, M., Elkholy, A., Elhakim, M., Samhouri, D., Reported direct and indirect contact with dromedary camels among laboratory-confirmed MERS-CoV cases (2018) Viruses, 10 (8), p. 425; Gautret, P., Charrel, R., Belhouchat, K., Drali, T., Benkouiten, S., Nougairede, A., Lack of nasal carriage of novel corona virus (HCoV-EMC) in French hajj pilgrims returning from the hajj 2012, despite a high rate of respiratory symptoms. Clin Microbiol Infect 2013;19(7):E315-E7; Harrath, R., Abu Duhier, F.M., Sero-prevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) specific antibodies in dromedary camels in Tabuk, Saudi Arabia (2018) J Med Virol, 90 (8), pp. 1285-1289; Harriman, K., Brosseau, L., Trivedi, K., Hospital-associated Middle East respiratory syndrome coronavirus infections (2013) N Engl J Med, 369 (18), p. 1761; Hu, B., Ge, X., Wang, L.-F., Shi, Z., Bat origin of human coronaviruses (2015) Virol J, 12 (1), p. 221; Hunter, J.C., Nguyen, D., Aden, B., Al Bandar, Z., Al Dhaheri, W., Elkheir, K.A., Transmission of Middle East respiratory syndrome coronavirus infections in healthcare settings, Abu Dhabi (2016) Emerg Infect Dis, 22 (4), p. 647; Kamau, E., Ongus, J., Gitau, G., Galgalo, T., Lowther, S.A., Bitek, A., Knowledge and practices regarding Middle East respiratory syndrome coronavirus among camel handlers in a slaughterhouse, Kenya, 2015 (2018) Zoonoses Public Health, 66 (1), pp. 169-173; Kazhal Mobaraki, K., Ahmadzadeh, J., An update to middle east respiratory syndrome coronavirus and risk of a pandemic in 2019 (2019) Clinical Microbiology and Infectious Diseases, 4 (1), p. 2; Lessler, J., Salje, H., Van Kerkhove, M.D., Ferguson, N.M., Cauchemez, S., Rodriquez-Barraquer, I., Estimating the severity and subclinical burden of Middle East respiratory syndrome coronavirus infection in the Kingdom of Saudi Arabia (2016) Am J Epidemiol, 183 (7), pp. 657-663; Majumder, M.S., Kluberg, S.A., Mekaru, S.R., Brownstein, J.S., Mortality risk factors for Middle East respiratory syndrome outbreak, South Korea, 2015 (2015) Emerg Infect Dis, 21 (11), p. 2088; Memish, Z.A., Zumla, A.I., Al-Hakeem, R.F., Al-Rabeeah, A.A., Stephens, G.M., Family cluster of Middle East respiratory syndrome coronavirus infections (2013) New England Journal of Medicine, 368 (26), pp. 2487-2494; Memish, Z.A., Almasri, M., Turkestani, A., Al-Shangiti, A.M., Yezli, S., Etiology of severe community-acquired pneumonia during the 2013 hajj—part of the MERS-CoV surveillance program (2014) Int J Infect Dis, 25, pp. 186-190; Mobaraki, K., Ahmadzadeh, J., Current epidemiological status of Middle East respiratory syndrome coronavirus in the world from 1.1. 2017 to 17.1. 2018: a cross-sectional study (2019) BMC Infect Dis, 19 (1), p. 351; Mobaraki, K., Ahmadzadeh, J., An update to middle east respiratory syndrome coronavirus and risk of a pandemic in 2019 (2019) Clinical Microbiology and Infectious Diseases, 4 (1), pp. 1-2; Park, J.W., Lee, K.J., Lee, K.H., Lee, S.H., Cho, J.R., Mo, J.W., Hospital outbreaks of middle east respiratory syndrome, Daejeon, South Korea, 2015 (2017) Emerg Infect Dis, 23 (6), p. 898; Petersen, E., Pollack, M.M., Madoff, L.C., Health-care associate transmission of Middle East respiratory syndrome corona virus, MERS-CoV, in the Kingdom of Saudi Arabia (2014) Int J Infect Dis, 29, pp. 299-300; Sherbini, N., Iskandrani, A., Kharaba, A., Khalid, G., Abduljawad, M., Hamdan, A.-J., Middle East respiratory syndrome coronavirus in Al-Madinah City, Saudi Arabia: demographic, clinical and survival data (2017) Journal of epidemiology and global health, 7 (1), pp. 29-36; Wang, Q., Qi, J., Yuan, Y., Xuan, Y., Han, P., Wan, Y., Bat origins of MERS-CoV supported by bat coronavirus HKU4 usage of human receptor CD26 (2014) Cell Host Microbe, 16 (3), pp. 328-337; World Health Organization, Emergencies preparedness, response:MERS-CoV.Disease outbreak news (2019), http://www.who.int/csr/don/archive/disease/coronavirus_infections/en/, Available from; Zumla, A., Hui, D.S., Perlman, S., Middle East respiratory syndrome (2015) The Lancet, 386 (9997), pp. 995-1007","Mohebbi, I.; Social Determinants of Health Research Center, Urmia University of Medical SciencesIran; email: irajmohebbi@umsu.ac.ir",,Elsevier Inc.,7328893,,DMIDD,31959375,English,Diagn. Microbiol. Infect. Dis.,Article,Final,Open Access,Scopus,2-s2.0-85078036304,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Barral-Arca R., Gómez-Carballa A., Cebey-López M., Bello X., Martinón-Torres F., Salas A.",57190378986;35724167900;56880377100;26324777000;56247826100;57200377210;,A meta-analysis of multiple whole blood gene expression data unveils a diagnostic host-response transcript signature for respiratory syncytial virus,2020,International Journal of Molecular Sciences,21,5,1831,,,,,10.3390/ijms21051831,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081244658&doi=10.3390%2fijms21051831&partnerID=40&md5=13449e8fbc2db7e0c33f999f76cd1e01,"Unidade de Xenética, Instituto de Ciencias Forenses, Facultade de Medicina, Universidade de Santiago de Compostela, and GenPoB Research Group, Instituto de Investigaciones Sanitarias (IDIS), Hospital Clínico Universitario de Santiago (SERGAS), Galicia, 15706, Spain; Translational Pediatrics and Infectious Diseases, Department of Pediatrics, Hospital Clínico Universitario de Santiago de Compostela, Galicia, 15706, Spain; Genetics, Vaccines and Infections Research Group (GENVIP), Instituto de Investigación Sanitaria de Santiago, Santiago de Compostela, 15706, Spain","Barral-Arca, R., Unidade de Xenética, Instituto de Ciencias Forenses, Facultade de Medicina, Universidade de Santiago de Compostela, and GenPoB Research Group, Instituto de Investigaciones Sanitarias (IDIS), Hospital Clínico Universitario de Santiago (SERGAS), Galicia, 15706, Spain, Translational Pediatrics and Infectious Diseases, Department of Pediatrics, Hospital Clínico Universitario de Santiago de Compostela, Galicia, 15706, Spain, Genetics, Vaccines and Infections Research Group (GENVIP), Instituto de Investigación Sanitaria de Santiago, Santiago de Compostela, 15706, Spain; Gómez-Carballa, A., Unidade de Xenética, Instituto de Ciencias Forenses, Facultade de Medicina, Universidade de Santiago de Compostela, and GenPoB Research Group, Instituto de Investigaciones Sanitarias (IDIS), Hospital Clínico Universitario de Santiago (SERGAS), Galicia, 15706, Spain, Translational Pediatrics and Infectious Diseases, Department of Pediatrics, Hospital Clínico Universitario de Santiago de Compostela, Galicia, 15706, Spain, Genetics, Vaccines and Infections Research Group (GENVIP), Instituto de Investigación Sanitaria de Santiago, Santiago de Compostela, 15706, Spain; Cebey-López, M., Unidade de Xenética, Instituto de Ciencias Forenses, Facultade de Medicina, Universidade de Santiago de Compostela, and GenPoB Research Group, Instituto de Investigaciones Sanitarias (IDIS), Hospital Clínico Universitario de Santiago (SERGAS), Galicia, 15706, Spain, Translational Pediatrics and Infectious Diseases, Department of Pediatrics, Hospital Clínico Universitario de Santiago de Compostela, Galicia, 15706, Spain, Genetics, Vaccines and Infections Research Group (GENVIP), Instituto de Investigación Sanitaria de Santiago, Santiago de Compostela, 15706, Spain; Bello, X., Unidade de Xenética, Instituto de Ciencias Forenses, Facultade de Medicina, Universidade de Santiago de Compostela, and GenPoB Research Group, Instituto de Investigaciones Sanitarias (IDIS), Hospital Clínico Universitario de Santiago (SERGAS), Galicia, 15706, Spain, Translational Pediatrics and Infectious Diseases, Department of Pediatrics, Hospital Clínico Universitario de Santiago de Compostela, Galicia, 15706, Spain, Genetics, Vaccines and Infections Research Group (GENVIP), Instituto de Investigación Sanitaria de Santiago, Santiago de Compostela, 15706, Spain; Martinón-Torres, F., Translational Pediatrics and Infectious Diseases, Department of Pediatrics, Hospital Clínico Universitario de Santiago de Compostela, Galicia, 15706, Spain, Genetics, Vaccines and Infections Research Group (GENVIP), Instituto de Investigación Sanitaria de Santiago, Santiago de Compostela, 15706, Spain; Salas, A., Unidade de Xenética, Instituto de Ciencias Forenses, Facultade de Medicina, Universidade de Santiago de Compostela, and GenPoB Research Group, Instituto de Investigaciones Sanitarias (IDIS), Hospital Clínico Universitario de Santiago (SERGAS), Galicia, 15706, Spain, Genetics, Vaccines and Infections Research Group (GENVIP), Instituto de Investigación Sanitaria de Santiago, Santiago de Compostela, 15706, Spain","Respiratory syncytial virus (RSV) is one of the major causes of acute lower respiratory tract infection worldwide. The absence of a commercial vaccine and the limited success of current therapeutic strategies against RSV make further research necessary. We used a multi-cohort analysis approach to investigate host transcriptomic biomarkers and shed further light on the molecular mechanism underlying RSV-host interactions. We meta-analyzed seven transcriptome microarray studies from the public Gene Expression Omnibus (GEO) repository containing a total of 922 samples, including RSV, healthy controls, coronaviruses, enteroviruses, influenzas, rhinoviruses, and coinfections, from both adult and pediatric patients. We identified > 1500 genes differentially expressed when comparing the transcriptomes of RSV-infected patients against healthy controls. Functional enrichment analysis showed several pathways significantly altered, including immunologic response mediated by RSV infection, pattern recognition receptors, cell cycle, and olfactory signaling. In addition, we identified a minimal 17-transcript host signature specific for RSV infection by comparing transcriptomic profiles against other respiratory viruses. These multi-genic signatures might help to investigate future drug targets against RSV infection. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.",Array; Meta-analysis; Respiratory syncytial virus; RNA; RSV; Transcriptomic,,"Brown, P.M., Schneeberger, D.L., Piedimonte, G., Biomarkers of respiratory syncytial virus (RSV) infection: Specific neutrophil and cytokine levels provide increased accuracy in predicting disease severity (2015) Paediatr. Respir. 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J. Mol. Sci.,Article,Final,Open Access,Scopus,2-s2.0-85081244658,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Sarmento L.V., Poonsuk K., Tian L., Mora-Díaz J.C., Main R.G., Baum D.H., Zimmerman J.J., Giménez-Lirola L.G.",57212753325;55829767400;57215022444;57203878440;54420558500;57002743900;55434243900;55129193400;,Detection of porcine epidemic diarrhea virus–neutralizing antibody using high-throughput imaging cytometry,2020,Journal of Veterinary Diagnostic Investigation,32,2,,324,328,,,10.1177/1040638720903346,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079724839&doi=10.1177%2f1040638720903346&partnerID=40&md5=5062206f76f0e177c6af7bea387f9ed4,"Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, United States","Sarmento, L.V., Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, United States; Poonsuk, K., Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, United States; Tian, L., Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, United States; Mora-Díaz, J.C., Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, United States; Main, R.G., Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, United States; Baum, D.H., Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, United States; Zimmerman, J.J., Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, United States; Giménez-Lirola, L.G., Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, United States","Porcine epidemic diarrhea virus (PEDV) is an emerging porcine coronavirus that causes a tremendous economic burden on the swine industry. The assessment of PEDV-neutralizing antibody levels provides a valuable tool to assess and predict herd immunity. We evaluated the performance of a PEDV imaging cytometry–based high-throughput neutralization test (HTNT) and compared the HTNT to a fluorescent focus neutralization (FFN) assay using serum samples from pigs of known PEDV infection status (n = 159). Estimates of diagnostic sensitivity and specificity for HTNT and FFN assays derived from receiver-operator characteristic (ROC) curve analyses showed that both PEDV FFN and HTNT provided excellent diagnostic performance. However, in the laboratory, imaging cytometry provided an objective and semi-automated approach that removed human subjectivity from the testing process and reduced the read-time of a 96-well plate to < 4 min. In addition, imaging cytometry facilitated the rapid collection and long-term storage of test images and data for further evaluation or client consultation. For PEDV and other pathogens, imaging cytometry could provide distinct advantages over classic virus neutralization or FFN assays for the detection and quantitation of neutralizing antibody. © 2020 The Author(s).",imaging cytometry; neutralizing antibody; porcine epidemic diarrhea virus,,"Bjustrom-Kraft, J., Porcine epidemic diarrhea virus (PEDV) detection and antibody response in commercial growing pigs (2016) BMC Vet Res, 12, pp. 1-8; Chappell, C.L., Adenovirus 36 antibody detection: improving the standard serum neutralization assay (2017) J Virol Methods, 239, pp. 69-74; Chen, Q., Isolation and characterization of porcine epidemic diarrhea viruses associated with the 2013 disease outbreak among swine in the United States (2014) J Clin Microbiol, 52, pp. 234-243; Clement, T., Measurement of neutralizing antibodies against porcine epidemic diarrhea virus in sow serum, colostrum, and milk samples and in piglet serum samples after feedback (2016) J Swine Health Prod, 24, pp. 147-153; Gerber, P.F., Detection of antibodies against porcine epidemic diarrhea virus in serum and colostrum by indirect ELISA (2014) Vet J, 202, pp. 33-36; Gimenez-Lirola, L.G., Reactivity of porcine epidemic diarrhea virus structural proteins to antibodies against porcine enteric coronaviruses: diagnostic implications (2017) J Clin Microbiol, 55, pp. 1426-1436; Kärber, G., Contribution to the collective treatment of serial pharmacological trials (1931) Archiv Exp Pathol Pharmacol, 162, pp. 480-483. , German, [,]; Maistriau, M., A method for the detection of virus infectivity in single cells and real time: towards an automated fluorescence neutralization test (2017) Virus Res, pp. 2371-2376; Oh, J.S., Comparison of an enzyme-linked immunosorbent assay with serum neutralization test for serodiagnosis of porcine epidemic diarrhea virus infection (2005) J Vet Sci, 6, pp. 349-352; Okda, F., Development of an indirect ELISA, blocking ELISA, fluorescent microsphere immunoassay and fluorescent focus neutralization assay for serologic evaluation of exposure to North American strains of porcine epidemic diarrhea virus (2015) BMC Vet Res, 11, pp. 1-14; Pensaert, M.B., de Bouck, P., A new coronavirus-like particle associated with diarrhea in swine (1978) Arch Virol, 58, pp. 243-247; Poonsuk, K., Quantifying the effect of lactogenic antibody on porcine epidemic diarrhea virus infection in neonatal piglets (2016) Vet Microbiol, 197, pp. 83-92; Poonsuk, K., The effect of chemical clarification of oral fluids on porcine epidemic diarrhea virus antibody responses (2018) J Vet Diagn Invest, 30, pp. 937-941; Saif, L.J., (2012) Coronaviruses. In: Straw BE, ed. Diseases of Swine, pp. 501-524. , 9th ed., Ames, IA, Wiley-Blackwell; Schulz, L.L., Tonsor, G.T., Assessment of the economic impacts of porcine epidemic diarrhea virus in the United States (2015) J Anim Sci, 93, pp. 5111-5118; Scherba, G., Evaluation of responses to both oral and parenteral immunization modalities for porcine epidemic diarrhea virus in production units (2016) J Swine Health Prod, 24, pp. 29-35; Spearman, C., The method of “right and wrong cases” (constant stimuli) without Gauss’s formula (1908) Br J Psychol, 2, pp. 227-242; Song, D., Porcine epidemic diarrhea: a review of current epidemiology and available vaccines (2015) Clin Exp Vac Res, 4, p. 166; Stevenson, G.W., Emergence of porcine epidemic diarrhea virus in the United States: clinical signs, lesions, and viral genomic sequences (2013) J Vet Diagn Invest, 25, pp. 649-654; Thomas, J.T., Effect of porcine epidemic diarrhea virus infectious doses on infection outcomes in naïve conventional neonatal and weaned pigs (2015) PLoS One, 10, p. e0139266. , p","Giménez-Lirola, L.G.; Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State UniversityUnited States; email: luisggl@iastate.edu",,SAGE Publications Inc.,10406387,,,32065056,English,J. Vet. Diagn. Invest.,Article,Final,Open Access,Scopus,2-s2.0-85079724839,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wang J., Li Y., Wang S., Liu F.",57206677766;57192202823;55087474400;57188649000;,Dynamics of transmissible gastroenteritis virus internalization unraveled by single-virus tracking in live cells,2020,FASEB Journal,34,3,,4653,4669,,,10.1096/fj.201902455R,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078898134&doi=10.1096%2ffj.201902455R&partnerID=40&md5=2e7e49ff32c475b2b8a4fb858c375b9b,"Joint International Research Laboratory of Animal Health and Food Safety & Single Molecule Nanometry Laboratory (Sinmolab), Nanjing Agricultural University, Nanjing, China; Computational Optics Laboratory, School of Science, Jiangnan University, Wuxi, China","Wang, J., Joint International Research Laboratory of Animal Health and Food Safety & Single Molecule Nanometry Laboratory (Sinmolab), Nanjing Agricultural University, Nanjing, China; Li, Y., Joint International Research Laboratory of Animal Health and Food Safety & Single Molecule Nanometry Laboratory (Sinmolab), Nanjing Agricultural University, Nanjing, China; Wang, S., Joint International Research Laboratory of Animal Health and Food Safety & Single Molecule Nanometry Laboratory (Sinmolab), Nanjing Agricultural University, Nanjing, China, Computational Optics Laboratory, School of Science, Jiangnan University, Wuxi, China; Liu, F., Joint International Research Laboratory of Animal Health and Food Safety & Single Molecule Nanometry Laboratory (Sinmolab), Nanjing Agricultural University, Nanjing, China","Transmissible gastroenteritis virus (TGEV) is a swine enteropathogenic coronavirus that causes significant economic losses in swine industry. Current studies on TGEV internalization mainly focus on viral receptors, but the internalization mechanism is still unclear. In this study, we used single-virus tracking to obtain the detailed insights into the dynamic events of the TGEV internalization and depict the whole sequential process. We observed that TGEVs could be internalized through clathrin- and caveolae-mediated endocytosis, and the internalization of TGEVs was almost completed within ~2 minutes after TGEVs attached to the cell membrane. Furthermore, the interactions of TGEVs with actin and dynamin 2 in real time during the TGEV internalization were visualized. To our knowledge, this is the first report that single-virus tracking technique is used to visualize the entire dynamic process of the TGEV internalization: before the TGEV internalization, with the assistance of actin, clathrin, and caveolin 1 would gather around the virus to form the vesicle containing the TGEV, and after ~60 seconds, dynamin 2 would be recruited to promote membrane fission. These results demonstrate that TGEVs enter ST cells via clathrin- and caveolae-mediated endocytic, actin-dependent, and dynamin 2-dependent pathways. © 2020 Federation of American Societies for Experimental Biology",actin; caveolae; clathrin; dynamin 2; TGEV,actin; caveolin 1; clathrin; dynamin II; animal cell; Article; caveola; cell membrane; controlled study; endocytosis; fluorescence microscopy; immunofluorescence test; live cell imaging; male; nonhuman; pig; priority journal; testis; Transmissible gastroenteritis virus; virus attachment; virus entry; virus titration,"Laude, H., Rasschaert, D., Delmas, B., Godet, M., Gelfi, J., Charley, B., Molecular biology of transmissible gastroenteritis virus (1990) Vet Microbiol, 23, pp. 147-154; Salanueva, I.J., Carrascosa, J.L., Risco, C., Structural maturation of the transmissible gastroenteritis coronavirus (1999) J Virol, 73, pp. 7952-7964; Delmas, B., Gelfi, J., L'Haridon, R., Aminopeptidase N is a major receptor for the enteropathogenic coronavirus TGEV (1992) Nature, 357, pp. 417-420; 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Li, Q., Li, W., Yin, W., Single-particle tracking of human immunodeficiency virus type 1 productive entry into human primary macrophages (2017) ACS Nano, 11, pp. 3890-3903; Hoornweg, T.E., van Duijl-Richter, M.K.S., Ayala Nuñez, N.V., Albulescu, I.C., van Hemert, M.J., Smit, J.M., Dynamics of chikungunya virus cell entry unraveled by single-virus tracking in living cells (2016) J Virol, 90, pp. 4745-4756; Lakadamyali, M., Rust, M.J., Babcock, H.P., Zhuang, X., Visualizing infection of individual influenza viruses (2003) Proc Natl Acad Sci U S A, 100, pp. 9280-9285; Sun, E., Liu, A., Zhang, Z., Liu, S., Tian, Z., Pang, D., Real-time dissection of distinct dynamin-dependent endocytic routes of influenza A virus by quantum dot-based single-virus tracking (2017) ACS Nano, 11, pp. 4395-4406; McMahon, H.T., Boucrot, E., Molecular mechanism and physiological functions of clathrin-mediated endocytosis (2011) Nat Rev Mol Cell Bio, 12, pp. 517-533; Wang, L.H., Rothberg, K.G., Anderson, R.G., Mis-assembly of clathrin lattices on endosomes reveals a regulatory switch for coated pit formation (1993) J Cell Biol, 123, pp. 1107-1117; Dutta, D., Williamson, C.D., Cole, N.B., Donaldson, J.G., Pitstop 2 is a potent inhibitor of clathrin-independent endocytosis (2012) PLoS One, 7; Lajoie, P., Nabi, I.R., Lipid rafts, caveolae, and their endocytosis (2010) Int Rev Cel Mol Bio, 282, pp. 135-163; Rothberg, K.G., Ying, Y.S., Kamen, B.A., Anderson, R.G., Cholesterol controls the clustering of the glycophospholipid-anchored membrane receptor for 5-methyltetrahydrofolate (1990) J Cell Biol, 111, pp. 2931-2938; Danthi, P., Chow, M., Cholesterol removal by methyl-beta-cyclodextrin inhibits poliovirus entry (2004) J Virol, 78, pp. 33-41; Mooren, O.L., Galletta, B.J., Cooper, J.A., Roles for actin assembly in endocytosis (2012) Annu Rev Biochem, 81, pp. 661-686; Sampath, P., Pollard, T.D., Effects of cytochalasin, phalloidin, and pH on the elongation of actin filaments (1991) Biochemistry, 30, pp. 1973-1980; Hinshaw, J.E., Dynamin and its role in membrane fission (2000) Annu Rev Cell Dev Biol, 16, pp. 483-519; Macia, E., Ehrlich, M., Massol, R., Boucrot, E., Brunner, C., Kirchhausen, T., Dynasore, a cell-permeable inhibitor of dynamin (2006) Dev Cell, 10, pp. 839-850; 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Zhao, T., Cui, L., Yu, X., Zhang, Z., Shen, X., Hua, X., Porcine sapelovirus enters PK-15 cells via caveolae-dependent endocytosis and requires Rab7 and Rab11 (2019) Virology, 529, pp. 160-168; van der Schaar, H.M., Rust, M.J., Waarts, B.L., Characterization of the early events in dengue virus cell entry by biochemical assays and single-virus tracking (2007) J Virol, 81, pp. 12019-12028; Liu, H., Liu, Y., Liu, S., Pang, D.W., Xiao, G., Clathrin-mediated endocytosis in living host cells visualized through quantum dot labeling of infectious hematopoietic necrosis virus (2011) J Virol, 85, pp. 6252-6262; Yarar, D., Waterman-Storer, C.M., Schmid, S.L., A dynamic actin cytoskeleton functions at multiple stages of clathrin-mediated endocytosis (2005) Mol Biol Cell, 16, pp. 964-975; Boulant, S., Kural, C., Zeeh, J., Ubelmann, F., Kirchhausen, T., Actin dynamics counteract membrane tension during clathrin-mediated endocytosis (2011) Nat Cell Biol, 13, pp. 1124-1131; Parton, R.G., Joggerst, B., Simons, K., Regulated internalization of caveolae (1994) J Cell Biol, 127, pp. 1199-1215; Pelkmans, L., Püntener, D., Helenius, A., Local actin polymerization and dynamin recruitment in SV40-induced internalization of caveolae (2002) Science, 296, pp. 535-539; Miyauchi, K., Kim, Y., Latinovic, O., Morozov, V., Melikyan, G.B., HIV enters cells via endocytosis and dynamin-dependent fusion with endosomes (2009) Cell, 137, pp. 433-444","Liu, F.; Joint International Research Laboratory of Animal Health and Food Safety & Single Molecule Nanometry Laboratory (Sinmolab), Nanjing Agricultural UniversityChina; email: feiliu24@njau.edu.cn",,John Wiley and Sons Inc.,8926638,,FAJOE,32017270,English,FASEB J.,Article,Final,Open Access,Scopus,2-s2.0-85078898134,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Ma W.-X., Ran X.-W.",57216087734;35269932400;,The Management of Blood Glucose Should be Emphasized in the Treatment of COVID-19,2020,Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition,51,2,,146,150,,,10.12182/20200360606,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082561726&doi=10.12182%2f20200360606&partnerID=40&md5=33849ebc5b97cdb2625dc3ecd2b116d9,"Diabetic Foot Care Center, Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, 610041, China","Ma, W.-X., Diabetic Foot Care Center, Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, 610041, China; Ran, X.-W., Diabetic Foot Care Center, Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, 610041, China","Based on the higher mortality and the higher proportion of critically ill adults in coronavirus disease 2019 (COVID-19) patients with diabetes, good inpatient glycemic control is particularly important in the comprehensive treatment of COVID-19. Individualized blood glucose target goals and treatment strategies should be made according to specific circumstances of COVID-19 inpatients with diabetes. For mild patients, a strict glycemic control target (fasting plasma glucose (FPG) 4.4-6.1 mmol/L, 2-hour postprandial plasma glucose (2 h PG) 6.1-7.8 mmol/L) are recommended; a target for the glycemic control of common type patients (FPG 6.1-7.8 mmol/L, 2 h PG 7.8-10.0 mmol/L) and subcutaneous insulin deliver therapy are recommended; a target nonfasting blood glucose range of 10.0 mmol or less per liter for severe-type COVID-19 patients, a relatively Less stringent blood glucose control target (FPG 7.8-10.0 mmol/L, 2 h PG 7.8-13.9 mmol/L) for critically ill patients and intravenous insulin infusion therapy are recommended. Due to the rapid changes in the condition of some patients, the risk of diabetic ketoacidosis (DKA) or hyperglycemic hyperosmolar status (HHS) maybe occur during the treatment. Blood glucose monitoring, dynamic evaluation and timely adjustment of strategies should be strengthened to ensure patient safety and promote early recovery of patients. Copyright© by Editorial Board of Journal of Sichuan University (Medical Science Edition).","Blood glucose level; Blood glucose monitoring; Coronavirus disease 2019, COVID-19; Diabetes mellitus; Inpatient glycemic control; Insulin; Therapy",,,,,NLM (Medline),1672173X,,,32220179,Chinese,Sichuan Da Xue Xue Bao Yi Xue Ban,Review,Final,,Scopus,2-s2.0-85082561726,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Ahovan Z.A., Hashemi A., De Plano L.M., Gholipourmalekabadi M., Seifalian A.",57215668056;55683345300;56499317200;56480648500;7005344804;,"Bacteriophage based biosensors: Trends, outcomes and challenges",2020,Nanomaterials,10,3,501,,,,,10.3390/nano10030501,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081591911&doi=10.3390%2fnano10030501&partnerID=40&md5=edb2db63b58f6e98901ed316dbacec55,"Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 1985717443, Iran; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, 98166, Italy; Cellular and Molecular Research Centre, Iran University of Medical Sciences, Tehran, 1449614535, Iran; Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, 1449614535, Iran; Nanotechnology & Regenerative Medicine Commercialization Centre (NanoRegMed Ltd.), London BioScience Innovation Centre, London, NW1 0NH, United Kingdom","Ahovan, Z.A., Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 1985717443, Iran; Hashemi, A., Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, 1985717443, Iran; De Plano, L.M., Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, 98166, Italy; Gholipourmalekabadi, M., Cellular and Molecular Research Centre, Iran University of Medical Sciences, Tehran, 1449614535, Iran, Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, 1449614535, Iran; Seifalian, A., Nanotechnology & Regenerative Medicine Commercialization Centre (NanoRegMed Ltd.), London BioScience Innovation Centre, London, NW1 0NH, United Kingdom","Foodborne pathogens are one of the main concerns in public health, which can have a serious impact on community health and health care systems. Contamination of foods by bacterial pathogens (such as Staphylococcus aureus, Streptococci, Legionella pneumophila, Escherichia coli, Campylobacter jejuni and Salmonella typhimurium) results in human infection. A typical example is the current issue with Coronavirus, which has the potential for foodborne transmission and ruling out such concerns is often difficult. Although, the possible dissemination of such viruses via the food chain has been raised. Standard bacterial detection methods require several hours or even days to obtain the results, and the delay may result in food poisoning to eventuate. Conventional biochemical and microbiological tests are expensive, complex, time-consuming and not always reliable. Therefore, there are urgent demands to develop simple, cheap, quick, sensitive, specific and reliable tests for the detection of these pathogens in foods. Recent advances in smart materials, nanomaterials and biomolecular modeling have been a quantum leap in the development of biosensors in overcoming the limitations of a conventional standard laboratory assay. This research aimed to critically review bacteriophage-based biosensors, used for the detection of foodborne pathogens, as well as their trends, outcomes and challenges are discussed. The future perspective in the use of simple and cheap biosensors is in the development of lab-on-chips, and its availability in every household to test the quality of their food. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.",Bacteria; Bacteriophage; Biosensors; Coronavirus; Foodborne pathogens; Nanomaterials; Nanoparticles; Nanotechnology; Smart materials,,"Oliver, S.P., Jayarao, B.M., Almeida, R.A., Foodborne pathogens in milk and the dairy farm environment: Food safety and public health implications (2005) Foodborne Pathog. 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Methods, 10, pp. 5061-5070","Hashemi, A.; Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical SciencesIran; email: ali.hashemi@sbmu.ac.ir",,MDPI AG,20794991,,,,English,Nanomaterials,Review,Final,Open Access,Scopus,2-s2.0-85081591911,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Sun Z., Thilakavathy K., Kumar S.S., He G., Liu S.V.",57215500987;35106201200;57197068577;57211532135;37102444700;,Potential factors influencing repeated SARS outbreaks in China,2020,International Journal of Environmental Research and Public Health,17,5,1633,,,,,10.3390/ijerph17051633,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081008159&doi=10.3390%2fijerph17051633&partnerID=40&md5=a32074512415f7f4b869100d1a3d3952,"Department of Biomedical Sciences, Faculty of Medicine & Health Sciences, University Putra Malaysia, UPM, Serdang, Selangor 43400, Malaysia; Genetics and Regenerative Medicine Research Group, Faculty of Medicine & Health Sciences, University Putra Malaysia, UPM, Serdang, Selangor 43400, Malaysia; Department of Medical Microbiology and Parasitology, University Putra Malaysia, UPM, Serdang, Selangor 43400, Malaysia; Institute of Health, Kunming Medical University, Kunming, 650500, China; Eagle Institute of Molecular Medicine, Apex, NC 27523, United States","Sun, Z., Department of Biomedical Sciences, Faculty of Medicine & Health Sciences, University Putra Malaysia, UPM, Serdang, Selangor 43400, Malaysia; Thilakavathy, K., Department of Biomedical Sciences, Faculty of Medicine & Health Sciences, University Putra Malaysia, UPM, Serdang, Selangor 43400, Malaysia, Genetics and Regenerative Medicine Research Group, Faculty of Medicine & Health Sciences, University Putra Malaysia, UPM, Serdang, Selangor 43400, Malaysia; Kumar, S.S., Genetics and Regenerative Medicine Research Group, Faculty of Medicine & Health Sciences, University Putra Malaysia, UPM, Serdang, Selangor 43400, Malaysia, Department of Medical Microbiology and Parasitology, University Putra Malaysia, UPM, Serdang, Selangor 43400, Malaysia; He, G., Institute of Health, Kunming Medical University, Kunming, 650500, China; Liu, S.V., Eagle Institute of Molecular Medicine, Apex, NC 27523, United States","Within last 17 years two widespread epidemics of severe acute respiratory syndrome (SARS) occurred in China, which were caused by related coronaviruses (CoVs): SARS-CoV and SARS-CoV-2. Although the origin(s) of these viruses are still unknown and their occurrences in nature are mysterious, some general patterns of their pathogenesis and epidemics are noticeable. Both viruses utilize the same receptor—angiotensin-converting enzyme 2 (ACE2)—for invading human bodies. Both epidemics occurred in cold dry winter seasons celebrated with major holidays, and started in regions where dietary consumption of wildlife is a fashion. Thus, if bats were the natural hosts of SARS-CoVs, cold temperature and low humidity in these times might provide conducive environmental conditions for prolonged viral survival in these regions concentrated with bats. The widespread existence of these bat-carried or-released viruses might have an easier time in breaking through human defenses when harsh winter makes human bodies more vulnerable. Once succeeding in making some initial human infections, spreading of the disease was made convenient with increased social gathering and holiday travel. These natural and social factors influenced the general progression and trajectory of the SARS epidemiology. However, some unique factors might also contribute to the origination of SARS in Wuhan. These factors are discussed in different scenarios in order to promote more research for achieving final validation. © 2020 by the authors. 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Dis., 3, p. 57; Xi, G.H., Adventures of Huanong Brothers: Shooting bamboo rat videos became popular, fans exceeded 5 million and annual income exceeded 300,000 Tencent, , https://new.qq.com/omn/20190205/20190205A0G1Q7.html, 5 February 2020, accessed on 18 February 2020; (2020) Live Science, , https://www.livescience.com/new-china-coronavirus-faq.html; Lau, S.K.P., Li, K.S.M., Huang, Y., Shek, C.-T., Tse, H., Wang, M., Choi, G.K.Y., Guo, R.T., Ecoepidemiology and complete genome comparison of different strains of severe acute respiratory syndrome-related Rhinolophus bat coronavirus in China reveal bats as a reservoir for acute, self-limiting infection that allows recombination events (2010) J. Virol., 84, pp. 2808-2819; Voigt, C.C., Rehnig, K., Lindecke, O., Pētersons, G., Migratory bats are attracted by red light but not by warm-white light: Implications for the protection of nocturnal migrants (2018) Ecol. Evol., 8, pp. 9353-9361; Xiong, C.L., Jiang, L.F., Chen, Y., Jiang, Q.W., Evolution and variation of 2019-novel coronavirus (2020) Biorxiv","He, G.; Institute of Health, Kunming Medical UniversityChina; email: guozhong_he@vip.sina.com",,MDPI AG,16617827,,,32138266,English,Int. J. Environ. Res. Public Health,Review,Final,Open Access,Scopus,2-s2.0-85081008159,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Elkholy A.A., Grant R., Assiri A., Elhakim M., Malik M.R., Van Kerkhove M.D.",57191446321;57202636854;36607531400;56806803800;37031425300;15761388700;,MERS-CoV infection among healthcare workers and risk factors for death: Retrospective analysis of all laboratory-confirmed cases reported to WHO from 2012 to 2 June 2018,2020,Journal of Infection and Public Health,13,3,,418,422,,2,10.1016/j.jiph.2019.04.011,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064944234&doi=10.1016%2fj.jiph.2019.04.011&partnerID=40&md5=9601277ba2dc2f78e14bae4125a2a929,"Infectious Hazard Management Unit, Department of Health Emergencies, World Health Organization Regional Office for the Eastern Mediterranean, Cairo, Egypt; Centre for Global Health, Institut Pasteur, Paris, France; Department of Infectious Hazard Management, WHO Health Emergencies Programme, World Health Organization, Geneva, Switzerland; Ministry of Health, Riyadh, Saudi Arabia","Elkholy, A.A., Infectious Hazard Management Unit, Department of Health Emergencies, World Health Organization Regional Office for the Eastern Mediterranean, Cairo, Egypt; Grant, R., Centre for Global Health, Institut Pasteur, Paris, France, Department of Infectious Hazard Management, WHO Health Emergencies Programme, World Health Organization, Geneva, Switzerland; Assiri, A., Ministry of Health, Riyadh, Saudi Arabia; Elhakim, M., Infectious Hazard Management Unit, Department of Health Emergencies, World Health Organization Regional Office for the Eastern Mediterranean, Cairo, Egypt; Malik, M.R., Infectious Hazard Management Unit, Department of Health Emergencies, World Health Organization Regional Office for the Eastern Mediterranean, Cairo, Egypt; Van Kerkhove, M.D., Department of Infectious Hazard Management, WHO Health Emergencies Programme, World Health Organization, Geneva, Switzerland","Background: Approximately half of the reported laboratory-confirmed infections of Middle East respiratory syndrome coronavirus (MERS-CoV) have occurred in healthcare settings, and healthcare workers constitute over one third of all secondary infections. This study aimed to describe secondary cases of MERS-CoV infection among healthcare workers and to identify risk factors for death. Methods: A retrospective analysis was conducted on epidemiological data of laboratory-confirmed MERS-CoV cases reported to the World Health Organization from September 2012 to 2 June 2018. We compared all secondary cases among healthcare workers with secondary cases among non-healthcare workers. Multivariable logistic regression identified risk factors for death. Results: Of the 2223 laboratory-confirmed MERS-CoV cases reported to WHO, 415 were healthcare workers and 1783 were non-healthcare workers. Compared with non-healthcare workers cases, healthcare workers cases were younger (P < 0.001), more likely to be female (P < 0.001), non-nationals (P < 0.001) and asymptomatic (P < 0.001), and have fewer comorbidities (P < 0.001) and higher rates of survival (P < 0.001). Year of infection (2013–2018) and having no comorbidities were independent protective factors against death among secondary healthcare workers cases. Conclusion: Being able to protect healthcare workers from high threat respiratory pathogens, such as MERS-CoV is important for being able to reduce secondary transmission of MERS-CoV in healthcare-associated outbreaks. By extension, reducing infection in healthcare workers improves continuity of care for all patients within healthcare facilities. © 2020 The Authors",Infection prevention and control; MERS-CoV; Nosocomial infection,adult; age; Article; asymptomatic infection; case fatality rate; comorbidity; comparative study; death; epidemiological data; female; gender; health care personnel; human; independent variable; infection prevention; major clinical study; male; Middle East respiratory syndrome; Middle East respiratory syndrome coronavirus; priority journal; retrospective study; risk assessment; risk factor; secondary analysis; secondary health care; secondary infection; survival rate; World Health Organization,"Zaki, A.M., van Boheemen, S., Bestebroer, T.M., Osterhaus, A.D., Fouchier, R.A., Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia (2012) N Engl J Med, 367, pp. 1814-1820; World Health Organization, WHO MERS-CoV global summary and assessment of risk: 21 July 2017 (2017), http://www.who.int/emergencies/mers-cov/risk-assessment-july-2017.pdf?ua=1, [Accessed 6 July 2018]; Hijawi, B., Abdallat, M., Sayaydeh, A., Alqasrawi, S., Haddadin, A., Jaarour, N., Novel coronavirus infections in Jordan, April 2012: epidemiological findings from a retrospective investigation (2013) East Mediterr Health J, 19, pp. S12-S18; Assiri, A., McGeer, A., Perl, T.M., Price, C.S., Al Rabeeah, A.A., Cummings, D.A., Hospital outbreak of Middle East respiratory syndrome coronavirus (2013) N Engl J Med, 369, pp. 407-416; Al-Abdallat, M.M., Payne, D.C., Alqasrawi, S., Rha, B., Tohme, R.A., Abedi, G.R., Hospital-associated outbreak of Middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description (2014) Clin Infect Dis, 59, pp. 1225-1233; Drosten, C., Muth, D., Corman, V.M., Hussain, R., Al Masri, M., HajOmar, W., An observational, laboratory-based study of outbreaks of Middle East respiratory syndrome coronavirus in Jeddah and Riyadh, Kingdom of Saudi Arabia, 2014 (2015) Clin Infect Dis, 60, pp. 369-377; Al Hosani, F., Pringle, K., Al Mulla, M., Kim, L., Pham, H., Alami, N.N., Response to emergence of Middle East respiratory syndrome coronavirus, Abu Dhabi, United Arab Emirates, 2013–2014 (2016) Emerg Infect Dis, 22 (7), pp. 1162-1168; Ki, M., MERS outbreak in Korea: hospital-to-hospital transmission (2015) Epidemiol Health, 37; Park, H.Y., Lee, E.J., Ryu, Y.W., Kim, Y., Kim, H., Lee, H., Epidemiological investigation of MERS-CoV spread in a single hospital in South Korea, May to June 2015 (2015) Euro Surveill, 20, pp. 1-6; Alfaraj, S.H., Al-Tawfiq, J.A., Altuwaijri, T.A., Alanazi, M., Alzahrani, N., Memish, Z.A., Middle East respiratory syndrome coronavirus transmission among health care workers: implication for infection control (2018) Am J Infect Control, 46, pp. 165-168; Fagbo, S.F., Skakni, L., Chu, D.K., Garbati, M.A., Joseph, M., Peiris, M., Molecular epidemiology of hospital outbreak of Middle East respiratory syndrome, Riyadh, Saudi Arabia, 2014 (2015) Emerg Infect Dis, 2, pp. 1981-1988; Guery, B., Poissy, J., el Mansouf, L., Séjourné, C., Ettahar, N., Lemaire, X., Clinical features and viral diagnosis of two cases of infection with Middle East respiratory syndrome coronavirus: a report of nosocomial transmission (2013) Lancet, 381, pp. 2265-2272; WHO MERS-CoV Research Group, State of knowledge and data gaps of Middle East respiratory syndrome coronavirus (MERS-CoV) in humans (2013) PLoS Curr, 5; Arabi, Y.M., Al-Omari, A., Mandourah, Y., Al-Hameed, F., Sindi, A.A., Alraddadi, B., Critically ill patients with the Middle East respiratory syndrome: a multicenter retrospective cohort study (2017) Crit Care Med, 45, pp. 1683-1695; Arabi, Y.M., Balkhy, H.H., Hayden, F.G., Bouchama, A., Luke, T., Baillie, J.K., Middle east respiratory syndrome (2017) N Engl J Med, 376, pp. 584-594; Al-Tawfiq, J.A., Alfaraj, S.H., Altuwaijri, T.A., Memish, Z.A., A cohort study of patients suspected for MERS-CoV in a referral hospital in Saudi Arabia (2017) J Infect, 75, pp. 378-379; International Health Regulations (2005) (2008), 2nd ed. World Health Organization Geneva; World Health Organization, Middle East respiratory syndrome case definition for reporting to WHO: interim case definition 26 July 2017 (2017), http://www.who.int/csr/disease/coronavirus_infections/mers-interim-case-definition.pdf?ua=1, [Accessed 6 July 2018]; Chan-Yeung, M., Severe acute respiratory syndrome (SARS) and healthcare workers (2004) Int J Occup Environ Health, 10 (4), pp. 421-427; Ministry of Health, Middle East respiratory syndrome coronavirus: guidelines for healthcare professionals — version 5.0, April (2018), https://www.moh.gov.sa/en/CCC/StaffRegulations/Corona/Pages/StaffRegulations.aspx#, [Accessed 2 August 2018]; Bin, S.Y., Heo, J.Y., Song, M.S., Lee, J., Kim, E.H., Park, S.J., Environmental contamination and viral shedding in MERS patients during MERS-CoV outbreak in South Korea (2016) Clin Infect Dis, 62, pp. 755-760; Kim, S.H., Chang, S.Y., Sung, M., Park, J.H., Bin Kim, H., Lee, H., Extensive viable Middle East respiratory syndrome (MERS) coronavirus contamination in air and surrounding environment in MERS outbreak units (2016) Clin Infect Dis, 63, pp. 363-369; van Doremalen, N., Bushmaker, T., Munster, V.J., Stability of Middle East respiratory syndrome coronavirus (MERS-CoV) under different environmental conditions (2013) Euro Surveill, 18. , pii=20590; Omrani, A.S., Matin, M.A., Haddad, Q., Al-Nakhli, D., Memish, Z.A., Albarrak, A.M., A family cluster of Middle East respiratory syndrome coronavirus infections related to a likely unrecognized asymptomatic or mild case (2013) Int J Infect Dis, 17, pp. e668-e672; Memish, Z.A., Assiri, A.M., Al-Tawfiq, J.A., Middle East respiratory syndrome coronavirus (MERS-CoV) viral shedding in the respiratory tract: an observational analysis with infection control implications (2014) Int J Infect Dis, 29, pp. 307-308; Al-Gethamy, M., Corman, V.M., Hussain, R., Al-Tawfiq, J.A., Drosten, C., Memish, Z.A., A case of long-term excretion and subclinical infection with Middle East respiratory syndrome coronavirus in a healthcare worker (2015) Clin Infect Dis, 60, pp. 973-974; Moon, S.Y., Son, J.S., Infectivity of an asymptomatic patient with Middle East respiratory syndrome coronavirus infection (2017) Clin Infect Dis, 64, pp. 1457-1458","Van Kerkhove, M.D.; Department of Infectious Hazard Management, WHO Health Emergencies Programme, World Health Organization, Avenue Appia 20, Switzerland; email: vankerkhovem@who.int",,Elsevier Ltd,18760341,,,31056437,English,J. Infect. Public Health,Article,Final,Open Access,Scopus,2-s2.0-85064944234,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Marraro G.A., Spada C.",7003598133;23490538200;,Consideration of the respiratory support strategy of severe acute respiratory failure caused by SARS-CoV-2 infection in children,2020,Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics,22,3,,183,194,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082292363&partnerID=40&md5=1f88a88a96cc6e2bf8071c1235022509,"Healthcare Accountability Lab, University of Milan, Milan, Italy","Marraro, G.A., Healthcare Accountability Lab, University of Milan, Milan, Italy; Spada, C.","The recent ongoing outbreak of severe pneumonia associated with a novel coronavirus (SARS-CoV-2), currently of unknown origin, creates a world emergency that has put global public health institutions on high alert. At present there is limited clinical information of the SARS-CoV-2 and there is no specific treatment recommended, although technical guidances and suggestions have been developed and will continue to be updated as additional information becomes available. Preventive treatment has an important role to control and avoid the spread of severe respiratory disease, but often is difficult to obtain and sometimes cannot be effective to reduce the risk of deterioration of the underlining lung pathology. In order to define an effective and safe treatment for SARS-CoV-2-associated disease, we provide considerations on the actual treatments, on how to avoid complications and the undesirable side effects related to them and to select and apply earlier the most appropriate treatment. Approaching to treat severe respiratory disease in infants and children, the risks related to the development of atelectasis starting invasive or non-invasive ventilation support and the risk of oxygen toxicity must be taken into serious consideration. For an appropriate and effective approach to treat severe pediatric respiratory diseases, two main different strategies can be proposed according to the stage and severity of the patient conditions: patient in the initial phase and with non-severe lung pathology and patient with severe initial respiratory impairment and/or with delay in arrival to observation. The final outcome is strictly connected with the ability to apply an appropriate treatment early and to reduce all the complications that can arise during the intensive care admission.",,"Betacoronavirus; child; complication; Coronavirus infection; human; respiratory failure; virus pneumonia; Betacoronavirus; Child; Coronavirus Infections; Humans; Pneumonia, Viral; Respiratory Insufficiency",,,,NLM (Medline),10088830,,,32204751,English,Zhongguo Dang Dai Er Ke Za Zhi,Article,Final,,Scopus,2-s2.0-85082292363,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Wu G.,57195690478;,"Important roles of dietary taurine, creatine, carnosine, anserine and 4-hydroxyproline in human nutrition and health",2020,Amino Acids,52,3,,329,360,,,10.1007/s00726-020-02823-6,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079805548&doi=10.1007%2fs00726-020-02823-6&partnerID=40&md5=871efb9cf3ecd501883f1976f916ce59,"Department of Animal Science and Faculty of Nutrition, Texas A&M University, College Station, TX 77843-2471, United States","Wu, G., Department of Animal Science and Faculty of Nutrition, Texas A&M University, College Station, TX 77843-2471, United States","Taurine (a sulfur-containing β-amino acid), creatine (a metabolite of arginine, glycine and methionine), carnosine (a dipeptide; β-alanyl-l-histidine), and 4-hydroxyproline (an imino acid; also often referred to as an amino acid) were discovered in cattle, and the discovery of anserine (a methylated product of carnosine; β-alanyl-1-methyl-l-histidine) also originated with cattle. These five nutrients are highly abundant in beef, and have important physiological roles in anti-oxidative and anti-inflammatory reactions, as well as neurological, muscular, retinal, immunological and cardiovascular function. Of particular note, taurine, carnosine, anserine, and creatine are absent from plants, and hydroxyproline is negligible in many plant-source foods. Consumption of 30 g dry beef can fully meet daily physiological needs of the healthy 70-kg adult human for taurine and carnosine, and can also provide large amounts of creatine, anserine and 4-hydroxyproline to improve human nutrition and health, including metabolic, retinal, immunological, muscular, cartilage, neurological, and cardiovascular health. The present review provides the public with the much-needed knowledge of nutritionally and physiologically significant amino acids, dipeptides and creatine in animal-source foods (including beef). Dietary taurine, creatine, carnosine, anserine and 4-hydroxyproline are beneficial for preventing and treating obesity, cardiovascular dysfunction, and ageing-related disorders, as well as inhibiting tumorigenesis, improving skin and bone health, ameliorating neurological abnormalities, and promoting well being in infants, children and adults. Furthermore, these nutrients may promote the immunological defense of humans against infections by bacteria, fungi, parasites, and viruses (including coronavirus) through enhancing the metabolism and functions of monocytes, macrophages, and other cells of the immune system. Red meat (including beef) is a functional food for optimizing human growth, development and health. © 2020, The Author(s).",Amino acids; Creatine; Function; Health; Metabolites; Peptides,alkaline phosphatase; anserine; beta alanine; carnosine; creatine kinase; creatinine; GABA transporter 2; GABA transporter 3; glycine; hydroxyproline; taurine; taurine transporter; amino acid intake; amino acid synthesis; amino acid transport; antioxidant activity; beef; cell metabolism; diet supplementation; dietary reference intake; DNA damage; electron transport; energy metabolism; heart failure; human; lipid peroxidation; macrophage; maize; monocyte; musculoskeletal function; neurologic disease; nonhuman; nutritional status; obesity; osmoregulation; oxidative stress; potato; priority journal; protein expression; protein intake; Review; rice; skin function; small intestine absorption; soybean; tissue distribution; turnover rate; wellbeing; wheat flour,"Abplanalp, W., Haberzettl, P., Bhatnagar, A., Carnosine supplementation mitigates the deleterious effects of particulate matter exposure in mice (2019) J Am Heart Assoc, 8; Adam, M., Spacek, P., Hulejova, H., Postmenopausal osteoporosis. 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Department of Animal Science and Faculty of Nutrition, Texas A&M UniversityUnited States; email: g-wu@tamu.edu",,Springer,9394451,,AACIE,32072297,English,Amino Acids,Review,Final,Open Access,Scopus,2-s2.0-85079805548,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Pardon B., Callens J., Maris J., Allais L., Van Praet W., Deprez P., Ribbens S.",26321150700;36503686300;56439147200;52563254300;57213826899;7101612249;12772253300;,Pathogen-specific risk factors in acute outbreaks of respiratory disease in calves,2020,Journal of Dairy Science,103,3,,2556,2566,,,10.3168/jds.2019-17486,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078066369&doi=10.3168%2fjds.2019-17486&partnerID=40&md5=3580a1cbc08f80f847fead3adc5e0533,"Department of Large Animal Internal Medicine, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, 9820, Belgium; Animal Health Service Flanders (DGZ Vlaanderen), Industrielaan 29, Torhout, 8820, Belgium; Boehringer Ingelheim Belgium, Arianelaan 16, Sint-Lambrechts-Wolume, 1200, Belgium","Pardon, B., Department of Large Animal Internal Medicine, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, 9820, Belgium; Callens, J., Animal Health Service Flanders (DGZ Vlaanderen), Industrielaan 29, Torhout, 8820, Belgium; Maris, J., Boehringer Ingelheim Belgium, Arianelaan 16, Sint-Lambrechts-Wolume, 1200, Belgium; Allais, L., Animal Health Service Flanders (DGZ Vlaanderen), Industrielaan 29, Torhout, 8820, Belgium; Van Praet, W., Animal Health Service Flanders (DGZ Vlaanderen), Industrielaan 29, Torhout, 8820, Belgium; Deprez, P., Department of Large Animal Internal Medicine, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, 9820, Belgium; Ribbens, S., Animal Health Service Flanders (DGZ Vlaanderen), Industrielaan 29, Torhout, 8820, Belgium","Respiratory tract infections (bovine respiratory disease) are a major concern in calf rearing. The objective of this study was to identify pathogen-specific risk factors associated with epidemic respiratory disease in calves. A cross-sectional study was conducted, involving 128 outbreaks (29 dairy, 58 dairy-mixed, and 41 beef) in Belgium (2016–2018). A semiquantitative PCR for 7 respiratory pathogens was done on a pooled nonendoscopic bronchoalveolar lavage sample for each herd. Potential risk factors were collected by questionnaire and derived from the national cattle registration databank. Most outbreaks occurred between October and March, and single and multiple viral infections were detected in 58.6% (75/128) and 13.3% (17/128), respectively. Bovine coronavirus (BCV) was the most frequently isolated virus (38.4%), followed by bovine respiratory syncytial virus (bRSV; 29.4%) and parainfluenzavirus type 3 (PI-3; 8.1%). Mycoplasma bovis, Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni were detected in 33.3, 41.2, 89.1, and 36.4% of the herds, respectively. Specific risk factors for BCV detection were detection of M. haemolytica [odds ratio (OR) = 2.8 (95% confidence interval = 1.1–7.5)], increasing herd size [OR = 1.3 (1.0–1.8) for each increase with 100 animals] and detection of BCV by antigen ELISA on feces in calves in the last year [OR = 3.6 (1.2–11.1)]. A seasonal effect was shown for bRSV only {more in winter compared with autumn [OR = 10.3 (2.8–37.5)]}. Other factors associated with bRSV were PI-3 detection [OR = 13.4 (2.1–86.0)], prevalence of calves with respiratory disease [OR = 1.02 (1.00–1.04) per 1% increase], and number of days with respiratory signs before sampling [OR = 0.99 (0.98–0.99) per day increase]. Next to its association with BCV, M. haemolytica was more frequently detected in herds with 5 to 10 animals per pen [OR = 8.0 (1.4–46.9)] compared with <5 animals, and in herds with sawdust as bedding [OR = 18.3 (1.8–191.6)]. Also, for H. somni, housing on sawdust was a risk factor [OR = 5.2 (1.2–23.0)]. Purchase of cattle [OR = 2.9 (1.0–8.0)] and housing of recently purchased animals in the same airspace [OR = 5.0 (1.5–16.5)] were risk factors for M. bovis. This study identified pathogen-specific risk factors that might be useful for the development of customized control and prevention and for the design of decision support tools to justify antimicrobial use by predicting the most likely pathogen before sampling results are available. © 2020 American Dairy Science Association",bovine respiratory disease; broncho-alveolar lavage; coronavirus; PCR,,"AMCRA, Classification of antimicrobials: Methods (2019), https://formularium.amcra.be/classification.php; Autio, T., Pohjanvirta, T., Holopainen, R., Rikula, U., Pentikainen, J., Huovilainen, A., Rusanen, H., Pelkonen, S., Etiology of respiratory disease in non-vaccinated, non-medicated calves in rearing herds (2007) Vet. 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Rec., 167, pp. 201-207. , 20693503; Pardon, B., Catry, B., Dewulf, J., Persoons, D., Hostens, M., De Bleecker, K., Deprez, P., Prospective study on quantitative and qualitative antimicrobial and anti-inflammatory drug use in white veal calves (2012) J. Antimicrob. Chemother., 67, pp. 1027-1038. , 22262796; Pardon, B., De Bleecker, K., Dewulf, J., Callens, J., Boyen, F., Catry, B., Deprez, P., Prevalence of respiratory pathogens in diseased, non-vaccinated, routinely medicated veal calves (2011) Vet. Rec., 169, p. 278. , 21831999; Pardon, B., De Bleecker, K., Hostens, M., Callens, J., Dewulf, J., Deprez, P., Longitudinal study on morbidity and mortality in white veal calves in Belgium (2012) BMC Vet. Res., 8, p. 26. , 22414223; Parker, A.M., Sheehy, P.A., Hazelton, M.S., Bosward, K.L., House, J.K., A review of mycoplasma diagnostics in cattle (2018) J. Vet. Intern. 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Assoc., 246, pp. 126-142. , 25517335; Thrusfield, M., Ortega, C., de Blas, I., Noordhuizen, J.P., Frankena, K., Win Episcope 2.0.: Improved epidemiological software for veterinary medicine (2001) Vet. Rec., 148, pp. 567-572; Timsit, E., Hallewell, J., Booker, C., Tison, N., Amat, S., Alexander, T.W., Prevalence and antimicrobial susceptibility of Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni isolated from the lower respiratory tract of healthy feedlot cattle and those diagnosed with bovine respiratory disease (2017) Vet. Microbiol., 208, pp. 118-125. , 28888626; Timsit, E., Le Dréan, E., Maingourd, C., Belloc, C., Guattéo, R., Bareille, N., Seegers, H., Assié, S., Detection by real-time RT-PCR of bovine respiratory syncytial virus vaccine in calves vaccinated intranasally (2009) Vet. Rec., 165, pp. 230-233. , 19700783; Timsit, E., Workentine, M., van der Meer, F., Alexander, T., Distinct bacterial metacommunities inhabit the upper and lower respiratory tracts of healthy feedlot cattle and those diagnosed with bronchopneumonia (2018) Vet. Microbiol., 221, pp. 105-113. , 29981695; Toftaker, I., Agren, E., Stokstad, M., Nodtvedt, A., Frossling, J., Herd level estimation of probability of disease freedom applied on the Norwegian control program for bovine respiratory syncytial virus and bovine coronavirus (2018) Prev. Vet. Med.; Toftaker, I., Sanchez, J., Stokstad, M., Nodtvedt, A., Bovine respiratory syncytial virus and bovine coronavirus antibodies in bulk tank milk - risk factors and spatial analysis (2016) Prev. Vet. Med., 133, pp. 73-83. , 27720029; Tolosa, T., Verbeke, J., Ayana, Z., Piepers, S., Supre, K., De Vliegher, S., Pathogen group specific risk factors for clinical mastitis, intramammary infection and blind quarters at the herd, cow and quarter level in smallholder dairy farms in Jimma, Ethiopia (2015) Prev. Vet. Med., 120, pp. 306-312. , 26008577; Van Driessche, L., Valgaeren, B.R., Gille, L., Boyen, F., Ducatelle, R., Haesebrouck, F., Deprez, P., Pardon, B., A deep nasopharyngeal swab versus nonendoscopic bronchoalveolar lavage for isolation of bacterial pathogens from preweaned calves with respiratory disease (2017) J. Vet. Intern. Med., 31, pp. 946-953. , 28425146; van Leenen, K., Van Driessche, L., De Cremer, L., Gille, L., Masmeijer, C., Boyen, F., Deprez, P., Pardon, B., Factors associated with lung cytology as obtained by non-endoscopic broncho-alveolar lavage in group-housed calves (2019) BMC Vet. Res., 15, p. 167. , 31126282; Workman, A.M., Kuehn, L.A., McDaneld, T.G., Clawson, M.L., Loy, J.D., Longitudinal study of humoral immunity to bovine coronavirus, virus shedding, and treatment for bovine respiratory disease in pre-weaned beef calves (2019) BMC Vet. Res., 15, p. 161. , 31118011","Pardon, B.; Department of Large Animal Internal Medicine, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Belgium; email: bart.pardon@ugent.be",,Elsevier Inc.,220302,,,,English,J. Dairy Sci.,Article,Final,Open Access,Scopus,2-s2.0-85078066369,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Duncan D., Lyall G.",57213646274;57215679949;,Understanding the coronavirus,2020,British Journal of Midwifery,28,3,,146,148,,,10.12968/bjom.2020.28.3.146,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081684606&doi=10.12968%2fbjom.2020.28.3.146&partnerID=40&md5=3ff199d9623b8125c085efa8467353dd,"Queen’s University, Belfast, United Kingdom","Duncan, D., Queen’s University, Belfast, United Kingdom; Lyall, G., Queen’s University, Belfast, United Kingdom","It is important to note that the current outbreak of novel coronavirus is rapidly changing, therefore, guidelines are likely to be updated as more data regarding COVID-19 becomes available (PHE, 2020; HPS, 2020). In the absence of any known treatment apart from supportive measures, healthcare professionals should keep up to date with the recommended guidelines in conjunction with local IPC guidance. © 2020 MA Healthcare Ltd. All rights reserved.",,Coronavirinae; human; nonhuman; practice guideline; review,"Overview of Coronaviruses. 2020, , https://bestpractice.bmj.com/topics/en-gb/3000165?q=Coronavirus,%202019%20novel&c=suggested, accessed 4 February 2020; (2020) Updated Advice-Novel Coronavirus (2019-Ncov), , CMO. Department of Health: Northern Ireland; Coronavirus Public Information Campaign Launched across the UK, , https://www.gov.uk/government/news/coronaviruspublic-information-campaign-launched-across-the-uk, Department of Health and Social Care. 2020a. accessed 4 February 2020; (2020) Coronavirus: Latest Information and Advice, , https://www.gov.uk/guidance/wuhan-novel-coronavirus-information-forthe-public, Department of health and social care and PHE. accessed 4 February 2020; Infection Control Advice for Secondary Care: Acute Respiratory Illness from Novel or Emerging Pathogens (Middle East Respiratory Syndrome Coronavirus (MERS-CoV), Avian Influenza (E.G. A/H7N9, A/H5N1) and Novel Coronavirus (2019-nCov)), p. 2020. , https://hpspubsrepo.blob.core.windows.net/hpswebsite/nss/2526/documents/1_20200131-avian-influenza-mers-cov-wn-cov-ipcp-guidance-v7.5.pdf, Health Protection Scotland. accessed 4 February 2020; Holmes, K.V., SARS-associated coronavirus (2003) New England Journal of Medicine, 348 (20), pp. 1948-1951; Jartti, L., Langen, H., Söderlund-Venermo, M., Vuorinen, T., Ruuskanen, O., Jartti, T., New respiratory viruses and the elderly (2011) Open Respiratory Medicine Journal, 5, pp. 61-69; Coronavirus (2019-nCoV). 2020, , https://www.nhs.uk/conditions/wuhan-novelcoronavirus/, accessed 4 February 2020; Phan, L.T., Nguyen, T.V., Luong, Q.C., Nguyen, T.V., Nguyen, H.T., Le, H.Q., Nguyen, T.T., Pham, Q.D., Importation and human-to-human transmission of a novel coronavirus in Vietnam The New England Journal of Medicine, p. 2020. , https://doi.org/10.1056/NEJMc2001272; (2020) Guidance: Novel Coronavirus (2019-nCoV) Infection Prevention and Control Guidance, , https://www.gov.uk/government/publications/wuhan-novel-coronavirusinfection-prevention-and-control/wuhannovel-coronavirus-wn-cov-infectionprevention-and-control-guidance, accessed 25 January 2020; Guidance: Coronavirus (COVID-19) – Latest Information and Advice 2020b, , https://www.gov.uk/guidance/wuhan-novel-coronavirus-information-forthe-public, accessed 27 January 2020; Guidance: Novel Coronavirus (2019-nCoV) – Epidemiology, Virology and Clinical Features, , https://www.gov.uk/government/publications/wuhan-novel-coronavirus-backgroundinformation/wuhan-novel-coronavirusepidemiology-virology-and-clinical-features, 2020c. accessed 4 February 2020; Guidance: Novel Coronavirus (2019-nCoV) Infection Prevention and Control Guidance, , https://www.gov.uk/government/publications/wuhan-novel-coronavirusinfection-prevention-and-control/wuhannovel-coronavirus-wn-cov-infectionprevention-and-control-guidance, 2020d. accessed 4 February 2020; Reynolds, M., How China’s coronavirus outbrea started, explained Wired. 2020, , https://www.wired.co.uk/article/china-coronavirus, accessed 3 February 2020; Rothe, C., Schunk, M., Sothmann, P., Sothmann, P., Bretzel, G., Froeschl, G., Wallrauch, C., Hoelscher, M., Transmission of 2019-nCoV infection from an asymptomatic contact in Germany The New England Journal of Medicine, p. 2020. , https://doi.org/10.1056/NEJMc2001468; Smuts, H., Workman, L., Zar, H.J., Role of human metapneumovirus, human coronavirus NL63 and human bocavirus in infants and young children with acute wheezing (2008) Journal of MedicalVirology, 80 (5), pp. 906-912. , https://doi.org/10.1002/jmv.21135; COVID-19 Coronavirus Outbreak. 2020, , https://www.worldometers.info/coronavirus/, accessed 26 February 2020; Infection Prevention and Control during Health Care When Novel Coronovirus (nCoV) Infection Is Suspected, , https://www.who.int/publications-detail/infection-prevention-and-control-during-health-care-when-novel-coronavirus-(ncov)-infection-is-suspected-20200125, 2020a. accessed 25 January 2020; Novel Coronavirus (2019-nCoV), , https://www.who.int/emergencies/diseases/novelcoronavirus-2019, 2020b. accessed 3 February 2020; Statement on the Second Meeting of the International Health Regulations (2005) Emergency Committee Regarding the Outbreak of Novel Coronavirus (2019-nCoV)., , https://www.who.int/news-room/detail/30-01-2020-statement-on-the-second-meeting-of-the-international-health-regulations-(2005)emergency-committee-regarding-the-outbreak-of-novel-coronavirus-(2019-ncov, 2020c. accessed 4 February 2020; Global Surveillance for Human Infection with Novel Coronavirus (2019-nCoV), , https://www.who.int/publications-detail/global-surveillance-forhuman-infection-with-novel-coronavirus-(2019-ncov, 2020d. accessed 3 February 2020; Zaki, A., Novel coronavirus—Saudi Arabia: Human isolate (2012) ProMed: International Socity of Infectious Diseases, , http://www.promedmail.org/direct.php?id=20120920.1302733",,,MA Healthcare Ltd,9694900,,,,English,Br. J. Midwifery,Review,Final,Open Access,Scopus,2-s2.0-85081684606,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Lai J., Ma S., Wang Y., Cai Z., Hu J., Wei N., Wu J., Du H., Chen T., Li R., Tan H., Kang L., Yao L., Huang M., Wang H., Wang G., Liu Z., Hu S.",56988340800;57215907600;57215014712;57215907820;57214939234;57215908267;57215908296;57215907303;57215907400;57214913664;57215907325;57214998984;55640011700;57215907806;57215866685;7407147911;57215692347;57215699132;,Factors Associated With Mental Health Outcomes Among Health Care Workers Exposed to Coronavirus Disease 2019,2020,JAMA network open,3,3,,e203976,,,,10.1001/jamanetworkopen.2020.3976,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082342319&doi=10.1001%2fjamanetworkopen.2020.3976&partnerID=40&md5=9c5fa62a92791e4b6c3d2364a42178ad,"Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, China; Department of Psychiatry, Wuhan Youfu Hospital, Wuhan, China; Department of Psychiatry, Jingmen No. 2 People's Hospital, Jingmen, China; Department of Psychiatry, Wuhan Wudong Hospital, Wuhan, China; Department of Nursing, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China","Lai, J., Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Ma, S., Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, China; Wang, Y., Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, China; Cai, Z., Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, China; Hu, J., Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Wei, N., Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Wu, J., Department of Psychiatry, Wuhan Youfu Hospital, Wuhan, China; Du, H., Department of Psychiatry, Jingmen No. 2 People's Hospital, Jingmen, China; Chen, T., Department of Psychiatry, Wuhan Wudong Hospital, Wuhan, China; Li, R., Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, China; Tan, H., Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, China; Kang, L., Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, China; Yao, L., Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, China; Huang, M., Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Wang, H., Department of Nursing, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Wang, G., Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, China; Liu, Z., Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan, China; Hu, S., Department of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China","Importance: Health care workers exposed to coronavirus disease 2019 (COVID-19) could be psychologically stressed. Objective: To assess the magnitude of mental health outcomes and associated factors among health care workers treating patients exposed to COVID-19 in China. Design, Settings, and Participants: This cross-sectional, survey-based, region-stratified study collected demographic data and mental health measurements from 1257 health care workers in 34 hospitals from January 29, 2020, to February 3, 2020, in China. Health care workers in hospitals equipped with fever clinics or wards for patients with COVID-19 were eligible. Main Outcomes and Measures: The degree of symptoms of depression, anxiety, insomnia, and distress was assessed by the Chinese versions of the 9-item Patient Health Questionnaire, the 7-item Generalized Anxiety Disorder scale, the 7-item Insomnia Severity Index, and the 22-item Impact of Event Scale-Revised, respectively. Multivariable logistic regression analysis was performed to identify factors associated with mental health outcomes. Results: A total of 1257 of 1830 contacted individuals completed the survey, with a participation rate of 68.7%. A total of 813 (64.7%) were aged 26 to 40 years, and 964 (76.7%) were women. Of all participants, 764 (60.8%) were nurses, and 493 (39.2%) were physicians; 760 (60.5%) worked in hospitals in Wuhan, and 522 (41.5%) were frontline health care workers. A considerable proportion of participants reported symptoms of depression (634 [50.4%]), anxiety (560 [44.6%]), insomnia (427 [34.0%]), and distress (899 [71.5%]). Nurses, women, frontline health care workers, and those working in Wuhan, China, reported more severe degrees of all measurements of mental health symptoms than other health care workers (eg, median [IQR] Patient Health Questionnaire scores among physicians vs nurses: 4.0 [1.0-7.0] vs 5.0 [2.0-8.0]; P = .007; median [interquartile range {IQR}] Generalized Anxiety Disorder scale scores among men vs women: 2.0 [0-6.0] vs 4.0 [1.0-7.0]; P < .001; median [IQR] Insomnia Severity Index scores among frontline vs second-line workers: 6.0 [2.0-11.0] vs 4.0 [1.0-8.0]; P < .001; median [IQR] Impact of Event Scale-Revised scores among those in Wuhan vs those in Hubei outside Wuhan and those outside Hubei: 21.0 [8.5-34.5] vs 18.0 [6.0-28.0] in Hubei outside Wuhan and 15.0 [4.0-26.0] outside Hubei; P < .001). Multivariable logistic regression analysis showed participants from outside Hubei province were associated with lower risk of experiencing symptoms of distress compared with those in Wuhan (odds ratio [OR], 0.62; 95% CI, 0.43-0.88; P = .008). Frontline health care workers engaged in direct diagnosis, treatment, and care of patients with COVID-19 were associated with a higher risk of symptoms of depression (OR, 1.52; 95% CI, 1.11-2.09; P = .01), anxiety (OR, 1.57; 95% CI, 1.22-2.02; P < .001), insomnia (OR, 2.97; 95% CI, 1.92-4.60; P < .001), and distress (OR, 1.60; 95% CI, 1.25-2.04; P < .001). Conclusions and Relevance: In this survey of heath care workers in hospitals equipped with fever clinics or wards for patients with COVID-19 in Wuhan and other regions in China, participants reported experiencing psychological burden, especially nurses, women, those in Wuhan, and frontline health care workers directly engaged in the diagnosis, treatment, and care for patients with COVID-19.",,,,,,NLM (Medline),25743805,,,32202646,English,JAMA Netw Open,Article,Final,Open Access,Scopus,2-s2.0-85082342319,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Perlis R.H.,34572658900;,Exercising Heart and Head in Managing Coronavirus Disease 2019 in Wuhan,2020,JAMA network open,3,3,,e204006,,,,10.1001/jamanetworkopen.2020.4006,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082342729&doi=10.1001%2fjamanetworkopen.2020.4006&partnerID=40&md5=5d691957d75bce1055598dbc1943e9d7,"Center for Quantitative Health and Department of Psychiatry, Massachusetts General Hospital, Boston; Associate Editor","Perlis, R.H., Center for Quantitative Health and Department of Psychiatry, Massachusetts General Hospital, Boston, Associate Editor",[No abstract available],,,,,,NLM (Medline),25743805,,,32202641,English,JAMA Netw Open,Article,Final,Open Access,Scopus,2-s2.0-85082342729,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Morse J.S., Lalonde T., Xu S., Liu W.R.",57189459143;57203847425;57215529921;16028904600;,Learning from the Past: Possible Urgent Prevention and Treatment Options for Severe Acute Respiratory Infections Caused by 2019-nCoV,2020,ChemBioChem,21,5,,730,738,,6,10.1002/cbic.202000047,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080087259&doi=10.1002%2fcbic.202000047&partnerID=40&md5=3476208702ae03da80298083818f4ffd,"The Texas A&M Drug Discovery Laboratory, Department of Chemistry, Texas A&M University, College Station, TX 77843, United States","Morse, J.S., The Texas A&M Drug Discovery Laboratory, Department of Chemistry, Texas A&M University, College Station, TX 77843, United States; Lalonde, T., The Texas A&M Drug Discovery Laboratory, Department of Chemistry, Texas A&M University, College Station, TX 77843, United States; Xu, S., The Texas A&M Drug Discovery Laboratory, Department of Chemistry, Texas A&M University, College Station, TX 77843, United States; Liu, W.R., The Texas A&M Drug Discovery Laboratory, Department of Chemistry, Texas A&M University, College Station, TX 77843, United States","With the current trajectory of the 2019-nCoV outbreak unknown, public health and medicinal measures will both be needed to contain spreading of the virus and to optimize patient outcomes. Although little is known about the virus, an examination of the genome sequence shows strong homology with its better-studied cousin, SARS-CoV. The spike protein used for host cell infection shows key nonsynonymous mutations that might hamper the efficacy of previously developed therapeutics but remains a viable target for the development of biologics and macrocyclic peptides. Other key drug targets, including RNA-dependent RNA polymerase and coronavirus main proteinase (3CLpro), share a strikingly high (>95 %) homology to SARS-CoV. Herein, we suggest four potential drug candidates (an ACE2-based peptide, remdesivir, 3CLpro-1 and a novel vinylsulfone protease inhibitor) that could be used to treat patients suffering with the 2019-nCoV. We also summarize previous efforts into drugging these targets and hope to help in the development of broad-spectrum anti-coronaviral agents for future epidemics. © 2020 Wiley-VCH Verlag GmbH & Co. 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Bull., 37, pp. 1021-1028","Xu, S.; The Texas A&M Drug Discovery Laboratory, Department of Chemistry, Texas A&M UniversityUnited States; email: shiqing.xu@tamu.edu",,Wiley-VCH Verlag,14394227,,CBCHF,32022370,English,ChemBioChem,Article,Final,Open Access,Scopus,2-s2.0-85080087259,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Ahmad T., Khan M., Khan F.M., Hui J.",57214283384;57214882537;57214884022;57214881151;,Are we ready for the new fatal Coronavirus: scenario of Pakistan?,2020,Human Vaccines and Immunotherapeutics,16,3,,736,738,,2,10.1080/21645515.2020.1724000,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079430741&doi=10.1080%2f21645515.2020.1724000&partnerID=40&md5=dd0e98375ae27dc254409b007d47957c,"Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China; Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, China; Department of Genetics, Centre for Human Genetics, Hazara University Mansehra, Khyber Pakhtunkhwa, Pakistan; Key Laboratory of Special Pathogens and Biosafety, Centre for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China","Ahmad, T., Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China, Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, China; Khan, M., Department of Genetics, Centre for Human Genetics, Hazara University Mansehra, Khyber Pakhtunkhwa, Pakistan; Khan, F.M., Key Laboratory of Special Pathogens and Biosafety, Centre for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China; Hui, J., Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China, Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, China",[No abstract available],,,"(2020), http://en.nhc.gov.cn/2020-02/04/c_76131.htm, Updated: 2020-02-04. [accessed, Feb 04]; (2020), https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6, accessed,. 2019-nCoV Global Cases by John Hopkins CSSE. [, Feb 04]; (2020), https://arynews.tv/en/first-coronavirus-case-diaged-in-pakistan/?fbclid=IwAR0FqYTBo3ZCFgAk_I23KCofZfS6goCVmUNyA9l6xZmIjIZREKCPDyXqdKc, accessed, Jan, 25,]; (2013) Infectious diseases in Pakistan: A clear and present danger, 381. , Lancet","Ahmad, T.; Department of Epidemiology and Health Statistics, School of Public Health, Southeast UniversityChina; email: tahmad@seu.edu.cn",,Taylor and Francis Inc.,21645515,,,32048891,English,Hum. Vaccines Immunother.,Note,Final,Open Access,Scopus,2-s2.0-85079430741,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Jang W.M., Kim U.-N., Jang D.H., Jung H., Cho S., Eun S.J., Lee J.Y.",37052176000;56206473600;57209685134;56438404000;57202913898;23496211100;57215579900;,Influence of trust on two different risk perceptions as an affective and cognitive dimension during Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak in South Korea: Serial cross-sectional surveys,2020,BMJ Open,10,3, e033026,,,,,10.1136/bmjopen-2019-033026,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081207706&doi=10.1136%2fbmjopen-2019-033026&partnerID=40&md5=c55679e2985a08812fcf33472f53360c,"Health Review and Assessment Committee, Health Insurance Review and Assessment Service, Wonju, South Korea; Division of Suicide Prevention Policy, Ministry of Health and Welfare, Sejong, South Korea; Department of Health Policy and Management, Seoul National University College of Medicine, Seoul, South Korea; Research Analytics and Communications, Gallup Korea, Seoul, South Korea; Department of Preventive Medicine, Chungnam National University College of Medicine, Daejeon, South Korea; Department of Public Health and Community Medicine, Seoul Metropolitan Government, Seoul National University Boramae Medical Center, Seoul, South Korea","Jang, W.M., Health Review and Assessment Committee, Health Insurance Review and Assessment Service, Wonju, South Korea; Kim, U.-N., Division of Suicide Prevention Policy, Ministry of Health and Welfare, Sejong, South Korea, Department of Health Policy and Management, Seoul National University College of Medicine, Seoul, South Korea; Jang, D.H., Research Analytics and Communications, Gallup Korea, Seoul, South Korea; Jung, H., Health Review and Assessment Committee, Health Insurance Review and Assessment Service, Wonju, South Korea, Department of Health Policy and Management, Seoul National University College of Medicine, Seoul, South Korea; Cho, S., Department of Health Policy and Management, Seoul National University College of Medicine, Seoul, South Korea; Eun, S.J., Department of Preventive Medicine, Chungnam National University College of Medicine, Daejeon, South Korea; Lee, J.Y., Department of Health Policy and Management, Seoul National University College of Medicine, Seoul, South Korea, Department of Public Health and Community Medicine, Seoul Metropolitan Government, Seoul National University Boramae Medical Center, Seoul, South Korea","Objectives This study aimed to assess the affective and cognitive risk perceptions in the general population of Middle East respiratory syndrome (MERS) during the 2015 MERS coronavirus (MERS-CoV) outbreak in South Korea and the influencing factors. Design Serial cross-sectional design with four consecutive surveys. Setting Nationwide general population in South Korea. Participants Overall 4010 respondents (aged 19 years and over) from the general population during the MERS-CoV epidemic were included. Primary and secondary outcome measures The main outcome measures were (1) affective risk perception, (2) cognitive risk perception, and (3) trust in the government. Multivariate logistic regression models were used to identify factors (demographic, socioeconomic, area and political orientation) associated with risk perceptions. Results Both affective and cognitive risk perceptions decreased as the MERS-CoV epidemic progressed. Proportions of affective risk perception were higher in all surveys and slowly decreased compared with cognitive risk perception over time. Females (adjusted OR (aOR) 1.72-2.00; 95% CI 1.14 to 2.86) and lower self-reported household economic status respondents were more likely to perceive the affective risk. The older the adults, the higher the affective risk perception, but the lower the cognitive risk perception compared with younger adults. The respondents who had low trust in the government had higher affective (aOR 2.19-3.11; 95 CI 1.44 to 4.67) and cognitive (aOR 3.55-5.41; 95 CI 1.44 to 9.01) risk perceptions. Conclusions This study suggests that even if cognitive risk perception is dissolved, affective risk perception can continue during MERS-CoV epidemic. Risk perception associating factors (ie, gender, age and self-reported household economic status) appear to be noticeably different between affective and cognitive dimensions. It also indicates that trust in the government influences affective risk perception and cognitive risk perception. There is a need for further efforts to understand the mechanism regarding the general public's risk perception for e €ective risk communication. © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.",epidemics; Middle East respiratory syndrome coronavirus; risk and perception; surveys,,"Ministry of Health and Welfare. The 2015 MERS outbreak in the Republic of Korea: learning from MERS. Sejong, Korea: Ministry of Health and Welfare, 2016; World Health Organization. WHO MERS-CoV global summary and assessment of risk. 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Moy, P., Pfau, M., (2000) With Malice Toward All?The Media and Public Confidence in Democratic Institutions, , The Media and Public Confidence in Democratic Institutions: ABC-CLIO; De Zwart, O., Veldhuijzen, I.K., Elam, G., Perceived threat, risk perception, and efficacy beliefs related to sars and other (emerging) infectious diseases: Results of an international survey (2009) J Behav Med, 16, pp. 30-40; Leung, G.M., Ho, L.-M., Chan, S.K.K., Longitudinal assessment of community psychobehavioral responses during and after the 2003 outbreak of severe acute respiratory syndrome in Hong Kong (2005) Clin Infect Dis, 40, pp. 1713-1720; Finucane, M.L., Slovic, P., Mertz, C.K., Gender, race, and perceived risk: The 'white Male' effect (2000) Health Risk Soc, 2, pp. 159-172; Davidson, D.J., Freudenburg, W.R., Gender and environmental risk concerns: A review and analysis of available research (1996) Environ Behav, 28, pp. 302-339; Weber, E.U., Blais, A.-R., Betz, N.E., A domain-specific risk-attitude scale: Measuring risk perceptions and risk behaviors (2002) J Behav Decis Mak, 15, pp. 263-290; Huang, L., Zhou, Y., Han, Y., Effect of the Fukushima nuclear accident on the risk perception of residents near a nuclear power plant in China (2013) Proc Natl Acad Sci U S A, 110, pp. 19742-19747; Benford, R.D., Moore, H.A., Williams, J.A., In whose backyard?: Concern about siting a nuclear waste facility (1993) Sociol Inq, 63, pp. 30-48; Johnson, B.B., Residential location and psychological distance in Americans' risk views and behavioral intentions regarding Zika virus (2018) Risk Anal, 38, pp. 2561-2579","Lee, J.Y.; Health Review and Assessment Committee, Health Insurance Review and Assessment ServiceSouth Korea; email: zepplin7@cnu.ac.kr",,BMJ Publishing Group,20446055,,,32139484,English,BMJ Open,Article,Final,Open Access,Scopus,2-s2.0-85081207706,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, COVID-19 National Incident Room Surveillance Team,,"COVID-19, Australia: Epidemiology Report 5 (Reporting week ending 19:00 AEDT 29 February 2020)",2020,Communicable diseases intelligence (2018),44,,,,,,,10.33321/cdi.2020.44.20,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080979608&doi=10.33321%2fcdi.2020.44.20&partnerID=40&md5=ee468798e4dc522c83635b9ba356723f,,COVID-19 National Incident Room Surveillance Team,"This is the fifth epidemiological report for coronavirus disease 2019 (COVID-19), reported in Australia as at 19:00 Australian Eastern Daylight Time [AEDT] 29 February 2020. It includes data on COVID-19 cases diagnosed in Australia, the international situation and a review of current evidence. © Commonwealth of Australia CC BY-NC-ND.",2019-nCoV; acute respiratory disease; Australia; case definition; coronavirus disease 2019; COVID-19; epidemiology; novel coronavirus; SARS-CoV-2,"COVID-19; adolescent; adult; aged; Australia; child; China; Coronavirus infection; epidemic; female; global health; health survey; human; incidence; male; middle aged; preschool child; travel; virus pneumonia; young adult; Adolescent; Adult; Aged; Australia; Child; Child, Preschool; China; Coronavirus Infections; Disease Outbreaks; Female; Global Health; Humans; Incidence; Male; Middle Aged; Pneumonia, Viral; Population Surveillance; Travel; Young Adult",,,,NLM (Medline),22096051,,,32126197,English,Commun Dis Intell (2018),Article,Final,Open Access,Scopus,2-s2.0-85080979608,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Li G.,57216037948;,The Challenges and Responsibilities of Family Doctors in the New Global Coronavirus Outbreak [家庭医生在新的全球冠状病毒疫情中面临的挑战和责任],2020,Chinese General Practice,23,7,,761,762,,,10.12114/j.issn.1007-9572.2020.00.247,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082509925&doi=10.12114%2fj.issn.1007-9572.2020.00.247&partnerID=40&md5=542dd00e596b1ed98c75b67d54c14ee4,,"Li, G.","A new coronavirus has begun to spread in Wuhan since December 2019.Primary medical and health institutions are the net bottom of the health service system, which plays an important fundamental role in community prevention and control of the new coronavirus epidemic and in advancing the threshold. It is also a critical moment that the roles and responsibilities of family doctors are assessed and recognised. We invited the President of WONCA Dr. Donald Li to explain the challenges and responsibilities of family doctors and primary medical teams in the face of this global crisis.It includes family doctors as ""gatekeepers"" in the fight against outbreaks and coordinators of primary care teams, improving their capabilities in an all-round way and actively carrying out business innovation etc. Copyright © 2020 by the Chinese General Practice.",Family doctors; Family medicine; General practice; Primary health care; SARS-CoV-2,,,"Li, G.",,Chinese General Practice,10079572,,,,Chinese,Chin. Gen. Pract.,Article,Final,,Scopus,2-s2.0-85082509925,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Xiao H., Zhang Y., Kong D., Li S., Yang N.",57215594890;57215614444;57215608052;57215597418;57200657022;,The Effects of Social Support on Sleep Quality of Medical Staff Treating Patients with Coronavirus Disease 2019 (COVID-19) in January and February 2020 in China,2020,Medical science monitor : international medical journal of experimental and clinical research,26,,,e923549,,,,10.12659/MSM.923549,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081379683&doi=10.12659%2fMSM.923549&partnerID=40&md5=655f329518c27669dbdad297c549ab6d,"Department of Respiration, Xuanwu Hospital Capital Medical UniversityBeijing, China; College of Humanities and Social Sciences, Harbin Engineering University, Harbin, Heilongjiang, China; School of Health Sciences, Wuhan University, Wuhan, Hubei, China","Xiao, H., Department of Respiration, Xuanwu Hospital Capital Medical UniversityBeijing, China; Zhang, Y., College of Humanities and Social Sciences, Harbin Engineering University, Harbin, Heilongjiang, China; Kong, D., College of Humanities and Social Sciences, Harbin Engineering University, Harbin, Heilongjiang, China; Li, S., School of Health Sciences, Wuhan University, Wuhan, Hubei, China; Yang, N., College of Humanities and Social Sciences, Harbin Engineering University, Harbin, Heilongjiang, China","BACKGROUND Coronavirus disease 2019 (COVID-19), formerly known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and 2019 novel coronavirus (2019-nCoV), was first identified in December 2019 in Wuhan City, China. Structural equation modeling (SEM) is a multivariate analysis method to determine the structural relationship between measured variables. This observational study aimed to use SEM to determine the effects of social support on sleep quality and function of medical staff who treated patients with COVID-19 in January and February 2020 in Wuhan, China. MATERIAL AND METHODS A one-month cross-sectional observational study included 180 medical staff who treated patients with COVID-19 infection. Levels of anxiety, self-efficacy, stress, sleep quality, and social support were measured using the and the Self-Rating Anxiety Scale (SAS), the General Self-Efficacy Scale (GSES), the Stanford Acute Stress Reaction (SASR) questionnaire, the Pittsburgh Sleep Quality Index (PSQI), and the Social Support Rate Scale (SSRS), respectively. Pearson's correlation analysis and SEM identified the interactions between these factors. RESULTS Levels of social support for medical staff were significantly associated with self-efficacy and sleep quality and negatively associated with the degree of anxiety and stress. Levels of anxiety were significantly associated with the levels of stress, which negatively impacted self-efficacy and sleep quality. Anxiety, stress, and self-efficacy were mediating variables associated with social support and sleep quality. CONCLUSIONS SEM showed that medical staff in China who were treating patients with COVID-19 infection during January and February 2020 had levels of anxiety, stress, and self-efficacy that were dependent on sleep quality and social support.",,"COVID-19; severe acute respiratory syndrome coronavirus 2; adult; anxiety; Betacoronavirus; China; Coronavirus infection; cross-sectional study; female; human; male; medical staff; mental stress; questionnaire; self concept; sleep; social support; virus pneumonia; Adult; Anxiety; Betacoronavirus; China; Coronavirus Infections; Cross-Sectional Studies; Female; Humans; Male; Medical Staff; Pneumonia, Viral; Self Efficacy; Sleep; Social Support; Stress, Psychological; Surveys and Questionnaires",,,,NLM (Medline),16433750,,,32132521,English,Med. Sci. Monit.,Article,Final,,Scopus,2-s2.0-85081379683,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Holshue M.L., DeBolt C., Lindquist S., Lofy K.H., Wiesman J., Bruce H., Spitters C., Ericson K., Wilkerson S., Tural A., Diaz G., Cohn A., Fox L., Patel A., Gerber S.I., Kim L., Tong S., Lu X., Lindstrom S., Pallansch M.A., Weldon W.C., Biggs H.M., Uyeki T.M., Pillai S.K., Washington State 2019-nCoV Case Investigation Team",36059050900;14035006000;55605556600;7801502832;6505850538;57215536260;55932435400;57215535860;57215535417;57215533364;57215534788;57215533230;57215533530;36139727300;56656063700;57215533873;55783951400;57216109835;57215534895;56943590300;8583331900;46460986500;55628581504;55480587300;,First case of 2019 novel coronavirus in the United States,2020,New England Journal of Medicine,382,10,,929,936,,82,10.1056/NEJMoa2001191,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080049274&doi=10.1056%2fNEJMoa2001191&partnerID=40&md5=8790011cf809dfbbfbd970a8238c2437,"Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, WA, United States; National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, WA, United States; Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, WA, United States; Influenza Division, Centers for Disease Control and Prevention, Atlanta, WA, United States; Division of Preparedness and Emerging Infections Centers for Disease Control and Prevention, Atlanta, WA, United States; Washington State Department of Health, Shoreline, WA, United States; Snohomish Health District, Everett, WA, United States; Providence Medical Group, Everett, WA, United States; Providence Regional Medical Center, Everett, WA, United States; Department of Medicine, University of Washington, School of Medicine, Seattle, WA, United States","Holshue, M.L., Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, WA, United States, Washington State Department of Health, Shoreline, WA, United States; DeBolt, C., Washington State Department of Health, Shoreline, WA, United States; Lindquist, S., Washington State Department of Health, Shoreline, WA, United States; Lofy, K.H., Washington State Department of Health, Shoreline, WA, United States; Wiesman, J., Washington State Department of Health, Shoreline, WA, United States; Bruce, H., Snohomish Health District, Everett, WA, United States; Spitters, C., Snohomish Health District, Everett, WA, United States, Department of Medicine, University of Washington, School of Medicine, Seattle, WA, United States; Ericson, K., Providence Medical Group, Everett, WA, United States; Wilkerson, S., Providence Regional Medical Center, Everett, WA, United States; Tural, A., Providence Regional Medical Center, Everett, WA, United States; Diaz, G., Providence Regional Medical Center, Everett, WA, United States; Cohn, A., National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, WA, United States; Fox, L., National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, WA, United States; Patel, A., National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, WA, United States; Gerber, S.I., Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, WA, United States; Kim, L., Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, WA, United States; Tong, S., Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, WA, United States; Lu, X., Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, WA, United States; Lindstrom, S., Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, WA, United States; Pallansch, M.A., Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, WA, United States; Weldon, W.C., Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, WA, United States; Biggs, H.M., Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, WA, United States; Uyeki, T.M., Influenza Division, Centers for Disease Control and Prevention, Atlanta, WA, United States; Pillai, S.K., Division of Preparedness and Emerging Infections Centers for Disease Control and Prevention, Atlanta, WA, United States; Washington State 2019-nCoV Case Investigation Team","An outbreak of novel coronavirus (2019-nCoV) that began in Wuhan, China, has spread rapidly, with cases now confirmed in multiple countries. We report the first case of 2019-nCoV infection confirmed in the United States and describe the identification, diagnosis, clinical course, and management of the case, including the patient's initial mild symptoms at presentation with progression to pneumonia on day 9 of illness. This case highlights the importance of close coordination between clinicians and public health authorities at the local, state, and federal levels, as well as the need for rapid dissemination of clinical information related to the care of patients with this emerging infection. Copyright © 2020 Massachusetts Medical Society.",,"alanine aminotransferase; alkaline phosphatase; aspartate aminotransferase; cefepime; creatine kinase; guaifenesin; ibuprofen; lactate dehydrogenase; ondansetron; paracetamol; remdesivir; sodium chloride; vancomycin; virus RNA; COVID-19; severe acute respiratory syndrome coronavirus 2; abdominal discomfort; adult; alanine aminotransferase blood level; alkaline phosphatase blood level; Article; aspartate aminotransferase blood level; case report; clinical article; clinical feature; Coronavirinae; coronavirus disease 2019; Coronavirus infection; coughing; crackle; creatine kinase blood level; evening dosage; fatigue; feces analysis; fever; high throughput sequencing; hospital acquired pneumonia; human; lactate dehydrogenase blood level; leukopenia; loading drug dose; loose feces; lung auscultation; male; nausea; nausea and vomiting; oxygen saturation; patient isolation; pneumonia; priority journal; pulse oximetry; real time reverse transcription polymerase chain reaction; rhinorrhea; Sanger sequencing; Severe acute respiratory syndrome coronavirus 2; tachycardia; thorax radiography; throat culture; thrombocytopenia; United States; virus genome; virus pneumonia; wheezing; whole genome sequencing; Betacoronavirus; blood analysis; China; Coronavirus infection; diagnostic imaging; disease exacerbation; DNA sequence; genetics; isolation and purification; lung; pathology; travel; virus pneumonia; Adult; Betacoronavirus; Blood Chemical Analysis; China; Coronavirus Infections; Disease Progression; Genome, Viral; Humans; Lung; Male; Pneumonia, Viral; Radiography, Thoracic; Sequence Analysis, DNA; Travel; United States","(2020) Pneumonia of Unknown Cause - China, , https://www.who.int/csr/don/05-january-2020-pneumonia-of-unkown-cause-china/en/; (2020) Novel Coronavirus - China, , https://www.who.int/csr/don/12-january-2020-novel-coronavirus-china/en/; Chan, J.F.-W., Yuan, S., Kok, K.-H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: A study of a family cluster (2020) Lancet, , January 24 Epub ahead of print; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, , January 24 Epub ahead of print; (2019) Novel Coronavirus, Wuhan, China: 2019-nCoV Situation Summary, , https://www.cdc.gov/coronavirus/2019-nCoV/summary.html, January 28, 2020; Phan, L.T., Nguyen, T.V., Luong, Q.C., Importation and human-to-human transmission of a novel coronavirus in Vietnam N Engl J Med; Wuhan Coronavirus (2019-nCoV) Global Cases, , https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6; (2020) Interim Guidance for Healthcare Professionals: Criteria to Guide Evaluation of Patients under Investigation (PUI) for 2019-nCoV., , https://www.cdc.gov/coronavirus/2019-nCoV/clinical-criteria.html; (2019) Infection Control, , https://www.cdc.gov/coronavirus/2019-nCoV/infection-control.html, Novel coronavirus, Wuhan, China. 2020; Mulangu, S., Dodd, L.E., Davey, R.T., Jr., A randomized, controlled trial of ebola virus disease therapeutics (2019) N Engl J Med, 381, pp. 2293-2303; Sheahan, T.P., Sims, A.C., Leist, S.R., Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV (2020) Nat Commun, 11, p. 222; (2020) Interim Guidelines for Collecting, Handling, and Testing Clinical Specimens from Patients under Investigation (PUIs) for 2019 Novel Coronavirus (2019-nCoV), , https://www.cdc.gov/coronavirus/2019-nCoV/guidelines-clinical-specimens.html; (2020) Real-Time RT-PCR Panel for Detection 2019-Novel Coronavirus, , https://www.cdc.gov/coronavirus/2019-ncov/downloads/rt-pcr-panel-for-detection-instructions.pdf, Centers for Disease Control and Prevention, Respiratory Viruses Branch, Division of Viral Diseases; (2020) 2019-Novel Coronavirus (2019-nCoV) Real-Time rRT-PCR Panel Primers and Probes, , https://www.cdc.gov/coronavirus/2019-ncov/downloads/rt-pcr-panel-primer-probes.pdf, Centers for Disease Control and Prevention, Respiratory Viruses Branch, Division of Viral Diseases; (2020) Information for Laboratories. 2019 Novel Coronavirus, , https://www.cdc.gov/coronavirus/2019-nCoV/guidance-laboratories.html, Wuhan, China; GenBank Overview, , https://www.ncbi.nlm.nih.gov/genbank/; GISAID (Global Initiative on Sharing All Influenza Data) Home Page, , https://www.gisaid.org/; Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 N Engl J Med; (2020) Novel Coronavirus Outbreak, , https://www.doh.wa.gov/Emergencies/Coronavirus; Chen, N., Zhou, M., Dong, X., Jr., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study (2020) Lancet, , January 30 Epub ahead of print","Holshue, M.L.; Washington State Department of Health Public Health Laboratories, 1610 NE 150th St., United States; email: michelle.holshue@doh.wa.gov",,Massachussetts Medical Society,284793,,NEJMA,32004427,English,New Engl. J. Med.,Article,Final,Open Access,Scopus,2-s2.0-85080049274,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Razai M.S., Doerholt K., Ladhani S., Oakeshott P.",57196746840;57209983626;57203627482;7005205251;,Coronavirus disease 2019 (covid-19): A guide for UK GPS,2020,The BMJ,368,, m800,,,,1,10.1136/bmj.m800,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081275949&doi=10.1136%2fbmj.m800&partnerID=40&md5=dcba54075ee28f29dce8ec62d5e5547e,"Population Health Research Institute, St George University of London, London, United Kingdom; St George's University Hospital NHS Foundation Trust, London, United Kingdom; Public Health England, London, United Kingdom","Razai, M.S., Population Health Research Institute, St George University of London, London, United Kingdom; Doerholt, K., St George's University Hospital NHS Foundation Trust, London, United Kingdom; Ladhani, S., Public Health England, London, United Kingdom; Oakeshott, P., Population Health Research Institute, St George University of London, London, United Kingdom",[No abstract available],,clinical protocol; comorbidity; convalescence; Coronavirinae; coronavirus disease 2019; coughing; critically ill patient; disease severity; dyspnea; fever; general practitioner; high risk population; human; mortality rate; nonhuman; Note; patient assessment; patient isolation; primary medical care; priority journal; public health; severe acute respiratory syndrome; United Kingdom; virus transmission; virus virulence; Coronavirus infection; practice guideline; Coronavirus Infections; General Practitioners; Humans; Practice Guidelines as Topic; United Kingdom,"(2020), https://www.gov.uk/government/publications/wuhan-novel-coronavirus-background-information/wuhan-novel-coronavirus-epidemiology-virology-and-clinical-features, Public Health England.covid-19: epidemiology, virology and clinical features; Coronavirus Disease 2019 (covid-19) Situation Report-29, , World Health Organization; (2020), https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200219-sitrep-30-covid-19.pdf?sfvrsn=6e50645-2, February; Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med, , 31995857; (2020) WHO Director-General's Remarks at the Media Briefing on COVID-2019 Outbreak on, , https://www.who.int/dg/speeches/detail/who-director-general-s-remarks-at-the-media-briefing-on-covid-2019-outbreak-on-17-february-2020, World Health Organization, 17 February 2020; Wu, Z., McGoogan, J.M., Characteristics of and important lessons from the coronavirus disease 2019 (covid-19) outbreak in China. Summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention (2020) JAMA, , 32091533; (2020), https://www.gov.uk/government/publications/wuhan-novelcoronavirus-initial-investigation-of-possible-cases/investigation-and-initial-clinicalmanagement-of-possible-cases-of-wuhan-novel-coronavirus-wn-cov-infection#interimdefinition-possible-cases, Public Health England Guidance.covid-19: investigation and initial clinical management of possible cases; https://www.gov.uk/government/publications/wn-cov-guidance-for-primary-care/wn-cov-interimguidance-for-primary-care, Public Health England.covid-19: interim guidance for primary care; (2020) Primary Care Providers and the Coronavirus (covid-19)., , https://www.england.nhs.uk/wp-content/uploads/2020/02/coronavirus-primary-care-briefing.pdf, Briefing NHS; (2020) Guidance for NHS Clinicians on Home Isolation of A Patient Whilst Being Tested for SARS-CoV-2, , https://www.gov.uk/government/publications/wuhannovel-coronavirus-self-isolation-for-patients-undergoing-testing/guidance-for-nhs-clinicianson-home-isolation-of-a-patient-whilst-being-tested-for-wuhan-novel-coronavirus, Public Health England","Razai, M.S.; Population Health Research Institute, St George University of LondonUnited Kingdom; email: mrazai@sgul.ac.uk",,BMJ Publishing Group,9598146,,BMJOA,32144127,English,BMJ,Note,Final,Open Access,Scopus,2-s2.0-85081275949,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, [No author name available],[No author id available],Coronavirus response: a focus on containment is still apt,2020,Nature,579,7797,,7,,,,10.1038/d41586-020-00623-2,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080980290&doi=10.1038%2fd41586-020-00623-2&partnerID=40&md5=1ef98703cc5b3949ac778c98bcb7d95a,,,"Despite COVID-19’s spread to new countries, the evidence suggests it is yet possible to curb the virus. [Figure not available: see fulltext.]. © 2020, Nature.",Diseases; Epidemiology; Infection; Virology,"Coronavirinae; editorial; nonhuman; virology; Coronavirus infection; human; influenza; Middle East respiratory syndrome coronavirus; pandemic; Coronavirus; Coronavirus Infections; Humans; Influenza, Human; Middle East Respiratory Syndrome Coronavirus; Pandemics","Simonsen, L., (2013) PLoS Med., 10. , PID: 24302890",,,Nature Research,280836,,NATUA,32127714,English,Nature,Editorial,Final,Open Access,Scopus,2-s2.0-85080980290,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Qiu J., Shen B., Zhao M., Wang Z., Xie B., Xu Y.",57215650563;57215657497;57202229152;57215668815;57215674672;8691041100;,A nationwide survey of psychological distress among Chinese people in the COVID-19 epidemic: Implications and policy recommendations,2020,General Psychiatry,33,2, e100213,,,,,10.1136/gpsych-2020-100213,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081574242&doi=10.1136%2fgpsych-2020-100213&partnerID=40&md5=28f24eb05fe17f1b1083395bee8262d4,"Shanghai Mental Health Center, Shanghai Jiaotong University, School of Medicine, Shanghai, China; Department of AI Health Informatics, Siuvo Inc, Shanghai, China","Qiu, J., Shanghai Mental Health Center, Shanghai Jiaotong University, School of Medicine, Shanghai, China; Shen, B., Department of AI Health Informatics, Siuvo Inc, Shanghai, China; Zhao, M., Shanghai Mental Health Center, Shanghai Jiaotong University, School of Medicine, Shanghai, China; Wang, Z., Shanghai Mental Health Center, Shanghai Jiaotong University, School of Medicine, Shanghai, China; Xie, B., Shanghai Mental Health Center, Shanghai Jiaotong University, School of Medicine, Shanghai, China; Xu, Y., Shanghai Mental Health Center, Shanghai Jiaotong University, School of Medicine, Shanghai, China","The Coronavirus Disease 2019 (COVID-19) epidemic emerged in Wuhan, China, spread nationwide and then onto half a dozen other countries between December 2019 and early 2020. The implementation of unprecedented strict quarantine measures in China has kept a large number of people in isolation and affected many aspects of people's lives. It has also triggered a wide variety of psychological problems, such as panic disorder, anxiety and depression. This study is the first nationwide large-scale survey of psychological distress in the general population of China during the COVID-19 epidemic. © Author(s) (or their employer(s)) 2020.",anxiety; depression; disease notification; panic disorder; psychological trauma,,"Sareen, J., Erickson, J., Medved, M.I., Risk factors for post-injury mental health problems (2013) Depress Anxiety, 30, pp. 321-7; Cheng, C., Jun, H., Liang, B., Psychological health diathesis assessment system: A nationwide survey of resilient trait scale for Chinese adults (2014) Stud Psychol Behav, 12, pp. 735-42; Roberts, T., Miguel Esponda, G., Krupchanka, D., Factors associated with health service utilisation for common mental disorders: A systematic review (2018) BMC Psychiatry, 18, p. 262; Allen, J., Balfour, R., Bell, R., Social determinants of mental health (2014) Int Rev Psychiatry, 26, pp. 392-407; Lowe, S.R., Sampson, L., Gruebner, O., Psychological resilience after Hurricane sandy: The influence of individual: The community-level factors on mental health after a large-scale natural disaster (2015) PLoS One, 10, p. e0125761; Wind, T.R., Komproe, I.H., The mechanisms that associate community social capital with post-disaster mental health: A multilevel model (2012) Soc Sci Med, 75, pp. 1715-20","Xu, Y.; Shanghai Mental Health Center, Shanghai Jiaotong University, School of MedicineChina; email: xuyifeng@smhc.org.cn",,BMJ Publishing Group,2517729X,,,,English,General Psychiatry,Review,Final,Open Access,Scopus,2-s2.0-85081574242,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Burke R.M., Midgley C.M., Dratch A., Fenstersheib M., Haupt T., Holshue M., Ghinai I., Jarashow M.C., Lo J., McPherson T.D., Rudman S., Scott S., Hall A.J., Fry A.M., Rolfes M.A.",57215793032;57215984278;57205416772;6602554188;57215533064;36059050900;57212449100;57205314412;57215793987;57215778086;57215793840;57215775454;57215807024;13407240200;57212275884;,"Active Monitoring of Persons Exposed to Patients with Confirmed COVID-19 - United States, January-February 2020",2020,MMWR. Morbidity and mortality weekly report,69,9,,245,246,,1,10.15585/mmwr.mm6909e1,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081945574&doi=10.15585%2fmmwr.mm6909e1&partnerID=40&md5=41fc24afe6f05e11bc426d7f3015aee9,,"Burke, R.M.; Midgley, C.M.; Dratch, A.; Fenstersheib, M.; Haupt, T.; Holshue, M.; Ghinai, I.; Jarashow, M.C.; Lo, J.; McPherson, T.D.; Rudman, S.; Scott, S.; Hall, A.J.; Fry, A.M.; Rolfes, M.A.","In December 2019, an outbreak of coronavirus disease 2019 (COVID-19), caused by the virus SARS-CoV-2, began in Wuhan, China (1). The disease spread widely in China, and, as of February 26, 2020, COVID-19 cases had been identified in 36 other countries and territories, including the United States. Person-to-person transmission has been widely documented, and a limited number of countries have reported sustained person-to-person spread.* On January 20, state and local health departments in the United States, in collaboration with teams deployed from CDC, began identifying and monitoring all persons considered to have had close contact† with patients with confirmed COVID-19 (2). The aims of these efforts were to ensure rapid evaluation and care of patients, limit further transmission, and better understand risk factors for transmission.",,severe acute respiratory syndrome coronavirus 2; Betacoronavirus; China; contact examination; Coronavirus infection; environmental exposure; epidemic; health survey; human; isolation and purification; travel related disease; United States; virology; Betacoronavirus; China; Contact Tracing; Coronavirus Infections; Disease Outbreaks; Environmental Exposure; Humans; Public Health Surveillance; Travel-Related Illness; United States,,,,NLM (Medline),1545861X,,,32134909,English,MMWR Morb. Mortal. Wkly. Rep.,Article,Final,Open Access,Scopus,2-s2.0-85081945574,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, [No author name available],[No author id available],Pet dog confirmed to have coronavirus,2020,Veterinary Record,186,9,,265,,,,10.1136/vr.m892,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081391474&doi=10.1136%2fvr.m892&partnerID=40&md5=8c1a53eaaab8cf6368bcc28938d365c9,,,[No abstract available],,2019 novel coronavirus infection; agriculture; animal welfare; cat; Coronavirus infection; disease severity; dog; England; epidemic; government; Hong Kong; human; nonhuman; Note; pet animal; Pomeranian dog; quarantine; severe acute respiratory syndrome; veterinary medicine; virus detection; virus transmission,,,,British Veterinary Association,424900,,VETRA,32139620,English,Vet. Rec.,Note,Final,,Scopus,2-s2.0-85081391474,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Ghebreyesus T.A., Swaminathan S.",6603643366;57215087894;,Scientists are sprinting to outpace the novel coronavirus,2020,The Lancet,395,10226,,762,764,,,10.1016/S0140-6736(20)30420-7,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079845597&doi=10.1016%2fS0140-6736%2820%2930420-7&partnerID=40&md5=22835069fed2654c768dbd6b58c4810e,"World Health Organization, Geneva, 1211, Switzerland","Ghebreyesus, T.A., World Health Organization, Geneva, 1211, Switzerland; Swaminathan, S., World Health Organization, Geneva, 1211, Switzerland",[No abstract available],,"2019 novel coronavirus; China; Coronavirinae; coronavirus disease 2019; Coronavirus infection; diagnostic test; disease transmission; epidemic; global health; health care; human; incubation time; infection control; infection prevention; nonhuman; Note; priority journal; scientist; sociology; virus shedding; Betacoronavirus; Coronavirus infection; developing country; health care planning; medical research; Melia azedarach; organization and management; public relations; science; virus pneumonia; COVID-19; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; Biomedical Research; Coronavirus Infections; Developing Countries; Health Planning; Humans; Interprofessional Relations; Melia azedarach; Pneumonia, Viral; Science","Coronavirus disease (COVID-2019) situation reports (2020), https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200218-sitrep-29-covid-19.pdf?sfvrsn=6262de9e_2, (Accessed 19 February 2020); WHO Director-General's opening remarks at the mission briefing on COVID-19 (2020), https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-mission-briefing-on-covid-19, (Accessed 19 February 2020); National capacities review tool for a novel coronavirus (nCoV) (2020), https://www.who.int/publications-detail/national-capacities-review-tool-for-a-novel-coronavirus-(ncov), (Accessed 19 February 2020); World experts and funders set priorities for COVID-19 research (2020), https://www.who.int/news-room/detail/12-02-2020-world-experts-and-funders-set-priorities-for-covid-19-research, (Accessed 19 February 2020); Middle East respiratory syndrome coronavirus (MERS-CoV) (2019), https://www.who.int/en/news-room/fact-sheets/detail/middle-east-respiratory-syndrome-coronavirus-(mers-cov), (Accessed 19 February 2020); Vital surveillances: the epidemiological characteristics of an outbreak of 2019 novel coronavirus disease (COVID-19)—China, 2020. China CDC Weekly (2020), http://weekly.chinacdc.cn/en/article/id/e53946e2-c6c4-41e9-9a9b-fea8db1a8f51, (Accessed 19 February 2020); Flagship report (2019), https://apps.who.int/gpmb/flagship_report.html, (Accessed 19 February 2020); WHO, China leaders discuss next steps in battle against coronavirus outbreak (2020), https://www.who.int/news-room/detail/28-01-2020-who-china-leaders-discuss-next-steps-in-battle-against-coronavirus-outbreak, (Accessed 19 February 2020)",,,Lancet Publishing Group,1406736,,LANCA,32105610,English,Lancet,Note,Final,Open Access,Scopus,2-s2.0-85079845597,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Chen H., Guo J., Wang C., Luo F., Yu X., Zhang W., Li J., Zhao D., Xu D., Gong Q., Liao J., Yang H., Hou W., Zhang Y.",24437611900;57195032853;56911474200;57214321484;56217789100;57214839957;57214837314;56643549700;57212303251;57214838329;57214835492;51765020700;57200145770;14038456000;,Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records,2020,The Lancet,395,10226,,809,815,,37,10.1016/S0140-6736(20)30360-3,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079288295&doi=10.1016%2fS0140-6736%2820%2930360-3&partnerID=40&md5=05e8ca00a84dad2b6f329a8ac73aec66,"Department of Gynaecology and Obstetrics, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China; Department of Paediatrics, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China; Clinical Medicine Research Centre of Prenatal Diagnosis and Birth Health in Hubei Province, Wuhan, Hubei, China; State Key Laboratory of Virology/Institute of Medical Virology, School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei, China; Department of Obstetrics and Gynaecology, Peking University First Hospital, Beijing, China; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States","Chen, H., Department of Gynaecology and Obstetrics, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China, Clinical Medicine Research Centre of Prenatal Diagnosis and Birth Health in Hubei Province, Wuhan, Hubei, China; Guo, J., Department of Gynaecology and Obstetrics, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China, Clinical Medicine Research Centre of Prenatal Diagnosis and Birth Health in Hubei Province, Wuhan, Hubei, China; Wang, C., Department of Obstetrics and Gynaecology, Peking University First Hospital, Beijing, China; Luo, F., State Key Laboratory of Virology/Institute of Medical Virology, School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei, China; Yu, X., Department of Gynaecology and Obstetrics, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China, Clinical Medicine Research Centre of Prenatal Diagnosis and Birth Health in Hubei Province, Wuhan, Hubei, China; Zhang, W., Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, United States; Li, J., Department of Gynaecology and Obstetrics, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China, Clinical Medicine Research Centre of Prenatal Diagnosis and Birth Health in Hubei Province, Wuhan, Hubei, China; Zhao, D., Department of Paediatrics, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China; Xu, D., Department of Gynaecology and Obstetrics, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China, Clinical Medicine Research Centre of Prenatal Diagnosis and Birth Health in Hubei Province, Wuhan, Hubei, China; Gong, Q., Department of Gynaecology and Obstetrics, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China, Clinical Medicine Research Centre of Prenatal Diagnosis and Birth Health in Hubei Province, Wuhan, Hubei, China; Liao, J., Department of Gynaecology and Obstetrics, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China, Clinical Medicine Research Centre of Prenatal Diagnosis and Birth Health in Hubei Province, Wuhan, Hubei, China; Yang, H., Department of Obstetrics and Gynaecology, Peking University First Hospital, Beijing, China; Hou, W., State Key Laboratory of Virology/Institute of Medical Virology, School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei, China; Zhang, Y., Department of Gynaecology and Obstetrics, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China, Clinical Medicine Research Centre of Prenatal Diagnosis and Birth Health in Hubei Province, Wuhan, Hubei, China","Background: Previous studies on the pneumonia outbreak caused by the 2019 novel coronavirus disease (COVID-19) were based on information from the general population. Limited data are available for pregnant women with COVID-19 pneumonia. This study aimed to evaluate the clinical characteristics of COVID-19 in pregnancy and the intrauterine vertical transmission potential of COVID-19 infection. Methods: Clinical records, laboratory results, and chest CT scans were retrospectively reviewed for nine pregnant women with laboratory-confirmed COVID-19 pneumonia (ie, with maternal throat swab samples that were positive for severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) who were admitted to Zhongnan Hospital of Wuhan University, Wuhan, China, from Jan 20 to Jan 31, 2020. Evidence of intrauterine vertical transmission was assessed by testing for the presence of SARS-CoV-2 in amniotic fluid, cord blood, and neonatal throat swab samples. Breastmilk samples were also collected and tested from patients after the first lactation. Findings: All nine patients had a caesarean section in their third trimester. Seven patients presented with a fever. Other symptoms, including cough (in four of nine patients), myalgia (in three), sore throat (in two), and malaise (in two), were also observed. Fetal distress was monitored in two cases. Five of nine patients had lymphopenia (<1·0 × 10⁹ cells per L). Three patients had increased aminotransferase concentrations. None of the patients developed severe COVID-19 pneumonia or died, as of Feb 4, 2020. Nine livebirths were recorded. No neonatal asphyxia was observed in newborn babies. All nine livebirths had a 1-min Apgar score of 8–9 and a 5-min Apgar score of 9–10. Amniotic fluid, cord blood, neonatal throat swab, and breastmilk samples from six patients were tested for SARS-CoV-2, and all samples tested negative for the virus. Interpretation: The clinical characteristics of COVID-19 pneumonia in pregnant women were similar to those reported for non-pregnant adult patients who developed COVID-19 pneumonia. Findings from this small group of cases suggest that there is currently no evidence for intrauterine infection caused by vertical transmission in women who develop COVID-19 pneumonia in late pregnancy. Funding: Hubei Science and Technology Plan, Wuhan University Medical Development Plan. © 2020 Elsevier Ltd",,"alanine aminotransferase; aspartate aminotransferase; C reactive protein; COVID-19; severe acute respiratory syndrome coronavirus 2; abnormal laboratory result; adult; alanine aminotransferase blood level; amnion fluid analysis; Apgar score; Article; aspartate aminotransferase blood level; breast milk; cesarean section; China; clinical article; clinical feature; computer assisted tomography; Coronavirinae; coronavirus disease 2019; Coronavirus infection; coughing; diarrhea; female; fetus distress; fever; human; human cell; intrauterine infection; lactation; leukocyte count; live birth; lymphocytopenia; malaise; medical record review; myalgia; pregnancy; pregnant woman; priority journal; retrospective study; rigor; Severe acute respiratory syndrome coronavirus 2; sore throat; thorax pain; throat culture; umbilical cord blood; vertical transmission; virus pneumonia; Betacoronavirus; case report; complication; Coronavirus infection; coughing; dyspepsia; fever; isolation and purification; myalgia; newborn; pathogenicity; pharyngitis; pregnancy complication; pregnancy outcome; third trimester pregnancy; Betacoronavirus; Cesarean Section; Coronavirus Infections; Cough; Dyspepsia; Female; Fever; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Myalgia; Pharyngitis; Pneumonia, Viral; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Outcome; Pregnancy Trimester, Third; Retrospective Studies","Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, , published online Jan 24. DOI:; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, , published online Jan 24.; Notice on prevention and control of pneumonia in children and pregnant women with new coronavirus infection (2020), http://www.ljxw.gov.cn/news-93789.shtml, (in Chinese). (Accessed 4 February 2020); New coronavirus pneumonia prevention and control program (4th edn) (2020), http://www.gov.cn/zhengce/zhengceku/2020-01/28/5472673/files/0f96c10cc09d4d36a6f9a9f0b42d972b.pdf, (in Chinese). (Accessed 4 February 2020); Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected. Interim guidance (2020), https://www.who.int/docs/default-source/coronaviruse/clinical-management-of-novel-cov.pdf, (Accessed 4 February 2020); Laboratory testing for 2019 novel coronavirus (2019-nCoV) in suspected human cases. Interim guidance (2020), https://www.who.int/publications-detail/laboratory-testing-for-2019-novel-coronavirus-in-suspected-human-cases-20200117, (Accessed 4 February 2020); Corman, V.M., Landt, O., Kaiser, M., Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR (2020) Euro Surveill, 25, p. 2000045; Gottfredsson, M., The Spanish flu in Iceland 1918. Lessons in medicine and history (2008) Laeknabladid, 94, pp. 737-745. , (in Icelandic); Jamieson, D.J., Honein, M.A., Rasmussen, S.A., H1N1 2009 influenza virus infection during pregnancy in the USA (2009) Lancet, 374, pp. 451-458; Wong, S.F., Chow, K.M., Leung, T.N., Pregnancy and perinatal outcomes of women with severe acute respiratory syndrome (2004) Am J Obstet Gynecol, 191, pp. 292-297; Schoeman, D., Fielding, B.C., Coronavirus envelope protein: current knowledge (2019) Virol J, 16, p. 69; Zhang, Y.Z., Novel 2019 coronavirus genome (2020), http://virological.org/t/novel-2019-coronavirus-genome/319, (Accessed 4 February 2020); de Wit, E., van Doremalen, N., Falzarano, D., Munster, V.J., SARS and MERS: recent insights into emerging coronaviruses (2016) Nat Rev Microbiol, 14, pp. 523-534; Zhou, P., Yang, X.L., Wang, X.G., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature, , published online Feb 3. DOI:; Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med, , published online Jan 29. DOI:; Shek, C.C., Ng, P.C., Fung, G.P., Infants born to mothers with severe acute respiratory syndrome (2003) Pediatrics, 112, p. e254; Bouthry, E., Picone, O., Hamdi, G., Grangeot-Keros, L., Ayoubi, J.M., Vauloup-Fellous, C., Rubella and pregnancy: diagnosis, management and outcomes (2014) Prenat Diagn, 34, pp. 1246-1253; Niu, Y., Yue, H., Wuhan Tongji Hospital diagnoses first case of neonatal infection with new coronavirus (2020), http://society.people.com.cn/n1/2020/0205/c1008-31572959.html, (in Chinese). (Accessed 7 February 2020); Zhang, Z., Wang, C., Gao, C.C., Neonatal coronavirus expert confirmed at 30 hours of birth: vertical transmission from mother to infant (2020), http://www.cnr.cn/hubei/yuanchuang/20200205/t20200205_524961963.shtml, (in Chinese). (Accessed 10 February 2020)","Zhang, Y.; Department of Gynaecology and Obstetrics, Zhongnan Hospital of Wuhan UniversityChina; email: zhangyuanzhen@whu.edu.cn",,Lancet Publishing Group,1406736,,LANCA,32151335,English,Lancet,Article,Final,Open Access,Scopus,2-s2.0-85079288295,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Zhang M.-Z.,56461604200;,New coronavirus pneumonia COVID-19 and ocular surface transmission [关注新型冠状病毒肺炎与眼表传播问题],2020,International Eye Science,20,3,,401,403,,,10.3980/j.issn.1672-5123.2020.3.01,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081665911&doi=10.3980%2fj.issn.1672-5123.2020.3.01&partnerID=40&md5=c6935e34b3a6b195dc8f3af6ecd06556,"Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Shantou, 515041, China","Zhang, M.-Z., Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong, Shantou, 515041, China","Since the end of 2019, the novel coronavirus pneumonia (COVID-19) has rapidly spread in Wuhan City, Hubei Province of China. This has aroused great concern of the Chinese government and the international community. There have been unconfirmed threads of COVID-19 patients with conjunctivitis as the first symptom. Therefore, the issue that whether and how the novel coronavirus strain SARS-CoV-2 infection is transmitted through the ocular surface has become a new concern. In the absence of clinical and experimental evidence of COVID-19 in ocular infection, we have conducted a retrospective literature analysis of viral pathogens that simultaneously trigger ocular lesions during the onset of epidemic diseases. The purpose of this paper is to provide some reference and suggestions for appropriately understanding of ocular protection in the prevention and control of the COVID-19. Copyright 2020 by the IJO Press.",Infection; Ocular surface; Pneumonia; SARS-CoV-2; Transmission mode,Article; Coronavirinae; Coronavirus infection; eye; human; infection control; infection prevention; nonhuman; virus pneumonia; virus transmission,"Zhu, N., Zhang, D., Wang, W., A Novel Coronavirus from Patients with Pneumonia in China, 2019 (2020) N Engl J Med; Lu, R., Zhao, X., Li, J., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet; Lu, C.W., Liu, X.F., Jia, Z.F., 2019-nCoV transmission through the ocular surface must not be ignored (2020) Lancet; Belser, J.A., Rota, P.A., Tumpey, T.M., Ocular tropism of respiratory viruses (2013) Microbiol Mol Biol Rev, 77 (1), pp. 144-156; Khairallah, M., Kahloun, R., Ocular manifestations of emerging infectious diseases (2013) Curr Opin Ophthalmol, 24 (6), pp. 574-580; 李立明. 流行病学.第6版: 北京:人民卫生出版社 2007: 243-245; West, S., The red eye (2000) N Engl J Med, 343 (21), p. 1577; Azari, A.A., Barney, N.P., Conjunctivitis: a systematic review of diagnosis and treatment (2013) JAMA, 310 (16), pp. 1721-1729; Koopmans, M., Wilbrink, B., Conyn, M., Transmission of H7N7 avian influenza A virus to human beings during a large outbreak in commercial poultry farms in the Netherlands (2004) Lancet, 363 (9409), pp. 587-593; Belser, J.A., Lash, R.R., Garg, S., The eyes have it: influenza virus infection beyond the respiratory tract (2018) Lancet Infect Dis, 18 (7), pp. e220-e227; Sartori, M., La-Terra, G., Aglietta, M., Transmission of hepatitis C via blood splash into conjunctiva (1993) Scand J Infect Dis, 25 (2), pp. 270-271; 程秋兰. 血溅入结膜传播丙型肝炎病毒. 国外医学流行病学传染病学分册 1994; 1:38; 李建梅, 李翠平, 陈丽婷, 等. 医护人员眼部职业暴露原因分析. 国际医药卫生导报2014; 20(1):104-106; Hosoglu, S., Celen, M.K., Akalin, S., Transmission of hepatitis C by blood splash into conjunctiva in a nurse (2003) Am J Infect Control, 31 (8), pp. 502-504; Hayes, E.B., Zika virus outside Africa (2009) Emerg Infect Dis, 15 (9), pp. 1347-1350; Moss, W.J., Measles (2017) Lancet, 390 (10111), pp. 2490-2502; Gaines, H., Von-Sydow, M., Pehrson, P.O., Clinical picture of primary HIV infection presenting as a glandular-fever-like illness (1988) BMJ, 297 (6660), pp. 1363-1368; Galińska, E.M., Zagórski, J., Brucellosis in humans-etiology, diagnostics, clinical forms (2013) Ann Agric Environ Med, 20 (2), pp. 233-238; Mansour, D.E., El-Shazly, A.A., Elawamry, A.I., Comparison of ocular findings in patients with H1N1 influenza infection versus patients receiving influenza vaccine during a pandemic (2012) Ophthalmic Res, 48 (3), pp. 134-138; Belser, J.A., Gustin, K.M., Katz, J.M., Influenza virus infectivity and virulence following ocular-only aerosol inoculation of ferrets (2014) J Virol, 88 (17), pp. 9647-9654; Loon, S.C., Teoh, S.C., Oon, L.L., The severe acute respiratory syndrome coronavirus in tears (2004) Br J Ophthalmol, 88 (7), pp. 861-863; Jack J, Kanski BB, 赵译. Kanski临床眼科学(第7版). 北京: 北京大学医学出版社 2015: 132-147; Imai, Y., Kuba, K., Ohto-Nakanishi, T., Angiotensin-converting enzyme 2 (ACE2) in disease pathogenesis (2010) Circ J, 74 (3), pp. 405-410; Li, W., Moore, M.J., Vasilieva, N., Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus (2003) Nature, 426 (6965), pp. 450-454; Chan, W.M., Yuen, K.S., Fan, D.S., Tears and conjunctival scrapings for coronavirus in patients with SARS (2004) Br J Ophthalmol, 88 (7), pp. 968-969; 崔巍, 格日勒图, 高伟, 等. 传染性非典型肺炎患者泪液和血液中特异性抗体检测的对比研究. 内蒙古医学杂志 2004; 36(8):577-578; 马淮健, 王宏伟, 方立群, 等. 医务人员SARS感染的危险因素病例对照研究. 中华流行病学杂志 2004; 25(9): 741-744","Zhang, M.-Z.; Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong KongChina; email: zmz@jsiec.org",,International Journal of Ophthalmology (c/o Editorial Office),16725123,,,,Chinese,Intern. Eye Sci.,Article,Final,,Scopus,2-s2.0-85081665911,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Bwire G.M., Paulo L.S.",57208510099;57215581316;,Coronavirus disease-2019: Is fever an adequate screening for the returning travelers?,2020,Tropical Medicine and Health,48,1,201,,,,,10.1186/s41182-020-00201-2,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081207319&doi=10.1186%2fs41182-020-00201-2&partnerID=40&md5=9dc0cc20c2a77a2a6d0308f3bb1f4b9b,"School of Pharmacy, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania; School of Public Health and Social Sciences, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania","Bwire, G.M., School of Pharmacy, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania; Paulo, L.S., School of Public Health and Social Sciences, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Dar es Salaam, Tanzania","On Thursday, 30 January 2020, World Health Organization declared Coronavirus disease-2019 (COVID-2019) a Public Health Emergency of International Concern. Since its identification in late December 2019 in Wuhan, Hubei Province, People's Republic of China, the number of cases imported into other countries is increasing, and the epidemiological map is changing rapidly. On the other hand, body temperature screening (fever) is the major test performed at points of entry, i.e., airports, in the returning travelers in most of the countries with limited resources. However, the recent report on asymptomatic contact transmission of COVID-19 and travelers who passed the symptoms-based screening and tested positive for COVID-19 using reverse transcription polymerase chain reaction (RT-PCR) challenges this approach as body temperature screening may miss travelers incubating the disease or travelers concealing fever during travel. On this note, travel restrictions to and from high risk areas and/or 14 days quarantine of travelers coming from high risk areas are recommended to prevent possible importation of COVID-19. Currently, RT-PCR is a reliable test in detecting both symptomatic and asymptomatic COVID-19. © 2020 The Author(s).",COVID-19; Fever; Returning travelers; Temperature screening,airport; Article; asymptomatic infection; body temperature; Coronavirus disease 2019; Coronavirus infection; fever; high risk population; human; reverse transcription polymerase chain reaction; virus transmission; World Health Organization,"World Health Organization. Coronavirus Disease 2019 (COVID-19). Situational Report-37, , https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200226-sitrep-37-covid-19.pdf, Accessed 27 Feb 2020; World Health Organization (WHO), Novel Coronavirus (2019-nCoV), , https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports, Accessed 13 Feb 2020; Proclamation on Suspension of Entry As Immigrants and Nonimmigrants of Persons Who Pose A Risk of Transmitting 2019 Novel Coronavirus, , https://www.whitehouse.gov/presidential-actions/proclamation-suspension-entry-immigrants-nonimmigrants-persons-pose-risk-transmitting-2019-novel-coronavirus/, Accessed 11 Feb 2020; How Airports Are Screening Travelers for Deadly New Coronavirus-type Disease, , https://thepointsguy.com/news/how-airports-are-screening-travelers-for-deadly-new-coronavirus-type-disease/, Accessed 11 Feb 2020; World Health Organization, , https://www.who.int/ith/2020-24-01-outbreak-of-Pneumonia-caused-by-new-coronavirus/en/, Accessed 31 Jan 2020; Rothe, C., Transmission of 2019-nCoV infection from an asymptomatic contact in Germany (2020) N Engl J Med, pp. 2019-2020; Study Claiming New Coronavirus Can Be Transmitted by People without Symptoms Was Flawed, , https://www.sciencemag.org/news/2020/02/paper-non-symptomatic-patient-transmitting-coronavirus-wrong, Accessed 11 Feb 2020; Modular, L., Evidence of SARS-CoV-2 infection in returning travelers from Wuhan, China (2020) N Engl J Med., pp. 1-3; New Coronavirus Found in Japan Evacuees Who Initially Tested Negative, , https://www.straitstimes.com/asia/east-asia/new-coronavirus-found-in-japan-evacuees-who-initially-tested-negative, Accessed 12 Feb 2020; Coronavirus: UK Businessman Linked to Virus Cases Speaks out, , https://www.bbc.com/news/uk-51459210, Accessed 12 Feb 2020; Egypt Confirms Coronavirus Case, the First in Africa, , https://www.aljazeera.com/news/2020/02/egypt-confirms-coronavirus-case-africa-200214190840134.html, Accessed 15 Feb 2020; Algeria Announces First Confirmed Case of Coronavirus, , https://www.dailymaverick.co.za/article/2020-02-26-algeria-announces-first-confirmed-case-of-coronavirus/, Accessed 26 Feb 2020; Brazil Confirms First Coronavirus Case in Latin America, , https://www.aljazeera.com/news/2020/02/brazil-confirms-coronavirus-case-latin-america-200226144612605.html, Accessed 26 Feb 2020; Wang, D., Clinical Characteristics of 138 Hospitalized Patients with 2019 Novel coronavirus-infected pneumonia in Wuhan, China (2020) JAMA, pp. 1-9; WHO Sticks to 14-day Quarantine against Coronavirus, , https://www.straitstimes.com/singapore/health/who-sticks-to-14-day-quarantine-against-coronavirus, Accessed 27 Feb 2020; Kuan, M.M., Lin, T., Chuang, J.H., Wu, H.S., Epidemiological trends and the effect of airport fever screening on prevention of domestic dengue fever outbreaks in Taiwan, 1998-2007 (2010) Int J Infect Dis, 14 (8), pp. e693-e697; Thwaites, G.E., Day, N.P.J., Approach to fever in the returning traveler (2017) N Engl J Med, 376, pp. 548-560","Bwire, G.M.; School of Pharmacy, Muhimbili University of Health and Allied Sciences, P.O. Box 65001, Tanzania; email: georgebwire@gmail.com",,BioMed Central Ltd.,13488945,,,,English,Trop. Med. Health,Article,Final,Open Access,Scopus,2-s2.0-85081207319,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Neher R.A., Dyrdak R., Druelle V., Hodcroft E.B., Albert J.",6603836964;36716037900;57215835153;55917364500;7201985763;,Potential impact of seasonal forcing on a SARS-CoV-2 pandemic,2020,Swiss medical weekly,150,,,w20224,,,,10.4414/smw.2020.20224,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081998644&doi=10.4414%2fsmw.2020.20224&partnerID=40&md5=6209f69c944b7fdf6812a8979933af3a,"Biozentrum, University of Basel, Switzerland / Swiss Institute of Bioinformatics, Basel, Switzerland; Department of Clinical Microbiology, Karolinska University Hospital, Tumor and Cell Biology, Karolinska Institute, Sweden / Department of MicrobiologyStockholm, Sweden","Neher, R.A., Biozentrum, University of Basel, Switzerland / Swiss Institute of Bioinformatics, Basel, Switzerland; Dyrdak, R., Department of Clinical Microbiology, Karolinska University Hospital, Tumor and Cell Biology, Karolinska Institute, Sweden / Department of MicrobiologyStockholm, Sweden; Druelle, V., Biozentrum, University of Basel, Switzerland / Swiss Institute of Bioinformatics, Basel, Switzerland; Hodcroft, E.B., Biozentrum, University of Basel, Switzerland / Swiss Institute of Bioinformatics, Basel, Switzerland; Albert, J., Department of Clinical Microbiology, Karolinska University Hospital, Tumor and Cell Biology, Karolinska Institute, Sweden / Department of MicrobiologyStockholm, Sweden","A novel coronavirus (SARS-CoV-2) first detected in Wuhan, China, has spread rapidly since December 2019, causing more than 100,000 confirmed infections and 4000 fatalities (as of 10 March 2020). The outbreak has been declared a pandemic by the WHO on Mar 11, 2020. Here, we explore how seasonal variation in transmissibility could modulate a SARS-CoV-2 pandemic. Data from routine diagnostics show a strong and consistent seasonal variation of the four endemic coronaviruses (229E, HKU1, NL63, OC43) and we parameterise our model for SARS-CoV-2 using these data. The model allows for many subpopulations of different size with variable parameters. Simulations of different scenarios show that plausible parameters result in a small peak in early 2020 in temperate regions of the Northern Hemisphere and a larger peak in winter 2020/2021. Variation in transmission and migration rates can result in substantial variation in prevalence between regions. While the uncertainty in parameters is large, the scenarios we explore show that transient reductions in the incidence rate might be due to a combination of seasonal variation and infection control efforts but do not necessarily mean the epidemic is contained. Seasonal forcing on SARS-CoV-2 should thus be taken into account in the further monitoring of the global transmission. The likely aggregated effect of seasonal variation, infection control measures, and transmission rate variation is a prolonged pandemic wave with lower prevalence at any given time, thereby providing a window of opportunity for better preparation of health care systems.",,"COVID-19; China; Coronavirus infection; forecasting; human; incidence; pandemic; prevalence; season; theoretical model; virus pneumonia; China; Coronavirus Infections; Forecasting; Humans; Incidence; Models, Theoretical; Pandemics; Pneumonia, Viral; Prevalence; Seasons",,,,NLM (Medline),14243997,,,32176808,English,Swiss Med Wkly,Article,Final,Open Access,Scopus,2-s2.0-85081998644,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Guarner J.,7004588460;,"Three Emerging Coronaviruses in Two Decades: The Story of SARS, MERS, and Now COVID-19",2020,American Journal of Clinical Pathology,153,4,,420,421,,2,10.1093/ajcp/aqaa029,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080120084&doi=10.1093%2fajcp%2faqaa029&partnerID=40&md5=8e987f329afdd57b440c8e27134e88ee,"Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, United States","Guarner, J., Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, United States",[No abstract available],2019-nCoV; Coronavirus; COVID-19; MERS-CoV; SARS-CoV; SARS-CoV-2,"autopsy; case fatality rate; China; communicable disease; coronavirus disease 2019; Coronavirus infection; diagnostic imaging; Editorial; electron microscopy; epidemic; gene sequence; government; histopathology; human; Middle East; Middle East respiratory syndrome; nonhuman; priority journal; severe acute respiratory syndrome; United States; virus identification; virus transmission; World Health Organization; Betacoronavirus; Coronavirus infection; epidemic; genetics; Middle East respiratory syndrome coronavirus; pathogenicity; SARS coronavirus; severe acute respiratory syndrome; virus pneumonia; COVID-19; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; Coronavirus Infections; Disease Outbreaks; Humans; Middle East Respiratory Syndrome Coronavirus; Pneumonia, Viral; SARS Virus; Severe Acute Respiratory Syndrome","Ksiazek, T.G., Erdman, D., Goldsmith, C.S., A novel coronavirus associated with severe acute respiratory syndrome (2003) N Engl J Med., 348, pp. 1953-1966; (2005) Severe Acute Respiratory Syndrome (SARS), , https://www.cdc.gov/sars/guidance/b-surveillance/app1.html, Last reviewed. Accessed February 3, 2020; Hui, D.S., Azhar, E.I., Kim, Y.J., Middle East respiratory syndrome coronavirus: Risk factors and determinants of primary, household, and nosocomial transmission (2018) Lancet Infect Dis., 18, pp. e217-e227; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study [published online January 30, 2020] Lancet; (2020) Interim Guidelines for Collecting, Handling, and Testing Clinical Specimens from Patients under Investigation (PUIs) for 2019 Novel Coronavirus (2019-nCoV), , https://www.cdc.gov/coronavirus/2019-nCoV/lab/guidelines-clinical-specimens.html, Accessed February 3, 2020; (2020) Novel Coronavirus (2019-nCoV) Technical Guidance, , https://www.who.int/emergencies/diseases/novel-coronavirus-2019/technical-guidance, Accessed February 3, 2020","Guarner, J.; Department of Pathology and Laboratory Medicine, Emory UniversityUnited States; email: jguarne@emory.edu",,Oxford University Press,29173,,AJCPA,32053148,English,Am. J. Clin. Pathol.,Editorial,Final,Open Access,Scopus,2-s2.0-85080120084,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Salathé M., Althaus C.L., Neher R., Stringhini S., Hodcroft E., Fellay J., Zwahlen M., Senti G., Battegay M., Wilder-Smith A., Eckerle I., Egger M., Low N.",12780442200;8890140100;6603836964;28867486100;55917364500;57215424103;7004748418;57189927329;7004770044;35509574300;26635024600;34768019000;57215840311;,"COVID-19 epidemic in Switzerland: on the importance of testing, contact tracing and isolation",2020,Swiss medical weekly,150,,,w20225,,,,10.4414/smw.2020.20225,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082085668&doi=10.4414%2fsmw.2020.20225&partnerID=40&md5=aa5cc76cc9ac3bc7ad2133c8442afd45,"EPFL, Switzerland; University of Bern, Switzerland; University of Basel, Switzerland; CHUV/UNIL/EPFL, Switzerland, Switzerland; University Hospital Zurich, Switzerland; University Hospital Basel, Switzerland; London School of Hygiene and Tropical Medicine, London, United Kingdom; HCUGE, Switzerland, Switzerland","Salathé, M., EPFL, Switzerland; Althaus, C.L., University of Bern, Switzerland; Neher, R., University of Basel, Switzerland; Stringhini, S.; Hodcroft, E.; Fellay, J., CHUV/UNIL/EPFL, Switzerland, Switzerland; Zwahlen, M., University of Bern, Switzerland; Senti, G., University Hospital Zurich, Switzerland; Battegay, M., University Hospital Basel, Switzerland; Wilder-Smith, A., London School of Hygiene and Tropical Medicine, London, United Kingdom; Eckerle, I., HCUGE, Switzerland, Switzerland; Egger, M., University of Bern, Switzerland; Low, N., University of Bern, Switzerland","Switzerland is among the countries with the highest number of coronavirus disease-2019 (COVID-19) cases per capita in the world. There are likely many people with undetected SARS-CoV-2 infection because testing efforts are currently not detecting all infected people, including some with clinical disease compatible with COVID-19. Testing on its own will not stop the spread of SARS-CoV-2. Testing is part of a strategy. The World Health Organization recommends a combination of measures: rapid diagnosis and immediate isolation of cases, rigorous tracking and precautionary self-isolation of close contacts. In this article, we explain why the testing strategy in Switzerland should be strengthened urgently, as a core component of a combination approach to control COVID-19.",,"Betacoronavirus; contact examination; Coronavirus infection; epidemic; health survey; human; mass screening; patient isolation; quarantine; Switzerland; virus pneumonia; Betacoronavirus; Contact Tracing; Coronavirus Infections; Disease Outbreaks; Humans; Mass Screening; Patient Isolation; Pneumonia, Viral; Public Health Surveillance; Quarantine; Switzerland",,,,NLM (Medline),14243997,,,32191813,English,Swiss Med Wkly,Article,Final,Open Access,Scopus,2-s2.0-85082085668,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Desai A.N.,57211975966;,"Discussing the ABCs of Health Security - Antibiotic Resistance, Biothreats, and Coronavirus",2020,JAMA - Journal of the American Medical Association,323,10,,912,914,,,10.1001/jama.2019.21022,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080138917&doi=10.1001%2fjama.2019.21022&partnerID=40&md5=1af7656c736c773029d6b68fe2ea6bf1,,"Desai, A.N.",[No abstract available],,,,,,American Medical Association,987484,,JAMAA,32074261,English,JAMA,Note,Final,Open Access,Scopus,2-s2.0-85080138917,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wu A., Peng Y., Huang B., Ding X., Wang X., Niu P., Meng J., Zhu Z., Zhang Z., Wang J., Sheng J., Quan L., Xia Z., Tan W., Cheng G., Jiang T.",36611071500;36673675100;35082078200;57195806207;57214762384;56096165800;57214750844;57201482070;57201478370;57214760366;57214757439;55372330000;56714586800;57203643436;7401862533;7402148439;,Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China,2020,Cell Host and Microbe,27,3,,325,328,,16,10.1016/j.chom.2020.02.001,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079051459&doi=10.1016%2fj.chom.2020.02.001&partnerID=40&md5=ae74badf0c4a43f8d0005d0c6d5fedb0,"Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China; College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University, Changsha, 410082, China; Key Laboratory of Medical Virology, National Health and Family Planning Commission, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, 102206, China; School of Computer Science and Technology, Soochow University, Suzhou, China; Department of Cell Biology, School of Life Science, Central South University, Changsha, 410013, China; Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, United States; Suzhou Institute of Systems Medicine, Suzhou, Jiangsu 215123, China; Hunan Key Laboratory of Animal Models for Human Diseases, Hunan Key Laboratory of Medical Genetics & Center for Medical Genetics, School of Life Science, Central South University, Changsha, 410013, China","Wu, A., Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China, Suzhou Institute of Systems Medicine, Suzhou, Jiangsu 215123, China; Peng, Y., College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University, Changsha, 410082, China; Huang, B., Key Laboratory of Medical Virology, National Health and Family Planning Commission, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, 102206, China; Ding, X., Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China, Suzhou Institute of Systems Medicine, Suzhou, Jiangsu 215123, China; Wang, X., Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China, Suzhou Institute of Systems Medicine, Suzhou, Jiangsu 215123, China; Niu, P., Key Laboratory of Medical Virology, National Health and Family Planning Commission, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, 102206, China; Meng, J., Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China, Suzhou Institute of Systems Medicine, Suzhou, Jiangsu 215123, China; Zhu, Z., College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University, Changsha, 410082, China; Zhang, Z., College of Biology, Hunan Provincial Key Laboratory of Medical Virology, Hunan University, Changsha, 410082, China; Wang, J., Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China, Suzhou Institute of Systems Medicine, Suzhou, Jiangsu 215123, China; Sheng, J., Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China, Suzhou Institute of Systems Medicine, Suzhou, Jiangsu 215123, China; Quan, L., School of Computer Science and Technology, Soochow University, Suzhou, China; Xia, Z., Department of Cell Biology, School of Life Science, Central South University, Changsha, 410013, China, Hunan Key Laboratory of Animal Models for Human Diseases, Hunan Key Laboratory of Medical Genetics & Center for Medical Genetics, School of Life Science, Central South University, Changsha, 410013, China; Tan, W., Key Laboratory of Medical Virology, National Health and Family Planning Commission, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, 102206, China; Cheng, G., Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, United States; Jiang, T., Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China, Suzhou Institute of Systems Medicine, Suzhou, Jiangsu 215123, China","An in-depth annotation of the newly discovered coronavirus (2019-nCoV) genome has revealed differences between 2019-nCoV and severe acute respiratory syndrome (SARS) or SARS-like coronaviruses. A systematic comparison identified 380 amino acid substitutions between these coronaviruses, which may have caused functional and pathogenic divergence of 2019-nCoV. © 2020 Elsevier Inc.An in-depth annotation of the newly discovered coronavirus (2019-nCoV) genome has revealed differences between 2019-nCoV and severe acute respiratory syndrome (SARS) or SARS-like coronaviruses. A systematic comparison identified 380 amino acid substitutions between these coronaviruses, which may have caused functional and pathogenic divergence of 2019-nCoV. © 2020 Elsevier Inc.",,"amino acid substitution; article; China; nonhuman; SARS-related coronavirus; Betacoronavirus; China; classification; Middle East respiratory syndrome coronavirus; phylogeny; SARS coronavirus; virus genome; severe acute respiratory syndrome coronavirus 2; Amino Acid Substitution; Betacoronavirus; China; Genome, Viral; Middle East Respiratory Syndrome Coronavirus; Phylogeny; SARS Virus","Tracking the Epidemic (2020), http://weekly.chinacdc.cn/news/TrackingtheEpidemic.htm?from=timeline#Beijing%20Municipality%20Update; Cui, J., Li, F., Shi, Z.L., Origin and evolution of pathogenic coronaviruses (2019) Nat. Rev. Microbiol., 17, pp. 181-192; Drosten, C., Kellam, P., Memish, Z.A., Evidence for camel-to-human transmission of MERS coronavirus (2014) N. Engl. J. Med., 371, pp. 1359-1360; Ge, X.Y., Li, J.L., Yang, X.L., Chmura, A.A., Zhu, G., Epstein, J.H., Mazet, J.K., Peng, C., Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor (2013) Nature, 503, pp. 535-538; Guan, Y., Zheng, B.J., He, Y.Q., Liu, X.L., Zhuang, Z.X., Cheung, C.L., Luo, S.W., Guan, Y.J., Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China (2003) Science, 302, pp. 276-278; Guo, J.P., Petric, M., Campbell, W., McGeer, P.L., SARS corona virus peptides recognized by antibodies in the sera of convalescent cases (2004) Virology, 324, pp. 251-256; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Gu, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet; Jeffers, S.A., Tusell, S.M., Gillim-Ross, L., Hemmila, E.M., Achenbach, J.E., Babcock, G.J., Thomas, W.D., Jr., Mason, R.J., CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus (2004) Proc. Natl. Acad. Sci. USA, 101, pp. 15748-15753; Li, F., Structure, Function, and Evolution of Coronavirus Spike Proteins (2016) Annu. Rev. Virol., 3, pp. 237-261; Song, Z., Xu, Y., Bao, L., Zhang, L., Yu, P., Qu, Y., Zhu, H., Qin, C., From SARS to MERS, Thrusting Coronaviruses into the Spotlight (2019) Viruses, 11, p. E59; Tang, Q., Song, Y., Shi, M., Cheng, Y., Zhang, W., Xia, X.Q., Inferring the hosts of coronavirus using dual statistical models based on nucleotide composition (2015) Sci. Rep., 5, p. 17155; Zhou, P., Yang, X.-L., Wang, X.-G., Hu, B., Zhang, L., Zhang, W., Si, H.-R., Huang, C.-L., Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin (2020) bioRxiv; Zhu, Z., Zhang, Z., Chen, W., Cai, Z., Ge, X., Zhu, H., Jiang, T., Peng, Y., Predicting the receptor-binding domain usage of the coronavirus based on kmer frequency on spike protein (2018) Infect. Genet. evol., 61, pp. 183-184; Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., Zhao, X., Lu, R., A Novel Coronavirus from Patients with Pneumonia in China, 2019 (2020) N. Engl. J. Med.","Tan, W.; Key Laboratory of Medical Virology, National Health and Family Planning Commission, National Institute for Viral Disease Control and Prevention, China CDCChina; email: tanwj@ivdc.chinacdc.cn",,Cell Press,19313128,,,32035028,English,Cell Host and Microbe,Article,Final,,Scopus,2-s2.0-85079051459,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Kamel Boulos M.N., Geraghty E.M.",57211345116;57195248981;,Geographical tracking and mapping of coronavirus disease COVID-19/severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic and associated events around the world: how 21st century GIS technologies are supporting the global fight against outbreaks and epidemics,2020,International journal of health geographics,19,1,,8,,,,10.1186/s12942-020-00202-8,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081898318&doi=10.1186%2fs12942-020-00202-8&partnerID=40&md5=0160b6748f1b7cd067fb6aafb362d8fd,"School of Information Management, Sun Yat-sen University, East Campus, Guangzhou, Guangdong 510006, China; Esri (Environmental Systems Research Institute), 380 New York St, Redlands, CA, 92373, USA","Kamel Boulos, M.N., School of Information Management, Sun Yat-sen University, East Campus, Guangzhou, Guangdong 510006, China; Geraghty, E.M., Esri (Environmental Systems Research Institute), 380 New York St, Redlands, CA, 92373, USA","In December 2019, a new virus (initially called 'Novel Coronavirus 2019-nCoV' and later renamed to SARS-CoV-2) causing severe acute respiratory syndrome (coronavirus disease COVID-19) emerged in Wuhan, Hubei Province, China, and rapidly spread to other parts of China and other countries around the world, despite China's massive efforts to contain the disease within Hubei. As with the original SARS-CoV epidemic of 2002/2003 and with seasonal influenza, geographic information systems and methods, including, among other application possibilities, online real-or near-real-time mapping of disease cases and of social media reactions to disease spread, predictive risk mapping using population travel data, and tracing and mapping super-spreader trajectories and contacts across space and time, are proving indispensable for timely and effective epidemic monitoring and response. This paper offers pointers to, and describes, a range of practical online/mobile GIS and mapping dashboards and applications for tracking the 2019/2020 coronavirus epidemic and associated events as they unfold around the world. Some of these dashboards and applications are receiving data updates in near-real-time (at the time of writing), and one of them is meant for individual users (in China) to check if the app user has had any close contact with a person confirmed or suspected to have been infected with SARS-CoV-2 in the recent past. We also discuss additional ways GIS can support the fight against infectious disease outbreaks and epidemics.",COVID-19; GIS; SARS-CoV-2,"COVID-19; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; Coronavirus infection; geographic information system; human; pandemic; public health; virus pneumonia; Betacoronavirus; Coronavirus Infections; Geographic Information Systems; Humans; Pandemics; Pneumonia, Viral; Public Health",,,,NLM (Medline),1476072X,,,32160889,English,Int J Health Geogr,Editorial,Final,Open Access,Scopus,2-s2.0-85081898318,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, COVID-19 National Incident Room Surveillance Team,,"COVID-19, Australia: Epidemiology Report 6 (Reporting week ending 19:00 AEDT 7 March 2020)",2020,Communicable diseases intelligence (2018),44,,,,,,,10.33321/cdi.2020.44.21,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081695375&doi=10.33321%2fcdi.2020.44.21&partnerID=40&md5=07bd50378a31d77646010f99d7e883a4,,COVID-19 National Incident Room Surveillance Team,"This is the sixth epidemiological report for coronavirus disease 2019 (COVID-19), reported in Australia as at 19:00 Australian Eastern Daylight Time [AEDT] 7 March 2020. It includes data on COVID-19 cases diagnosed in Australia, the international situation and a review of current evidence. © Commonwealth of Australia CC BY-NC-ND.",2019-nCoV; acute respiratory disease; Australia; case definition; coronavirus disease 2019; COVID-19; epidemiology; novel coronavirus; SARS-CoV-2,"COVID-19; severe acute respiratory syndrome coronavirus 2; adolescent; adult; aged; Australia; Betacoronavirus; child; Coronavirus infection; female; global health; health survey; human; incidence; infant; male; middle aged; pathogenicity; preschool child; travel; virus pneumonia; young adult; Adolescent; Adult; Aged; Australia; Betacoronavirus; Child; Child, Preschool; Coronavirus Infections; Female; Global Health; Humans; Incidence; Infant; Male; Middle Aged; Pneumonia, Viral; Population Surveillance; Travel; Young Adult",,,,NLM (Medline),22096051,,,32156224,English,Commun Dis Intell (2018),Article,Final,Open Access,Scopus,2-s2.0-85081695375,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Nau J.-Y.,57215126971;,Épidémie de coronavirus et polémique sur la chloroquine,2020,Revue medicale suisse,16,685,,510,511,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081916392&partnerID=40&md5=07e19372a371dd8b6b22680f13647d39,,"Nau, J.-Y.",[No abstract available],,,,,,NLM (Medline),16609379,,,32167254,French,Rev Med Suisse,Note,Final,,Scopus,2-s2.0-85081916392,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Kiefer B.,34769651300;,"Coronavirus, responsabilité et fragilité",2020,Revue medicale suisse,16,685,,516,,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081893359&partnerID=40&md5=a32161f9d2cd235e60f674b320d2394b,,"Kiefer, B.",[No abstract available],,,,,,NLM (Medline),16609379,,,32167259,French,Rev Med Suisse,Editorial,Final,,Scopus,2-s2.0-85081893359,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Layne S.P., Hyman J.M., Morens D.M., Taubenberger J.K.",6701920673;7005695085;7005771082;7005069763;,New coronavirus outbreak: Framing questions for pandemic prevention,2020,Science translational medicine,12,534,,,,,,10.1126/scitranslmed.abb1469,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081683655&doi=10.1126%2fscitranslmed.abb1469&partnerID=40&md5=9bd82fb6371b44aa3773dd87bdc50b2d,"Scott P. Layne is emeritus professor in the Department of Epidemiology, UCLA School of Public Health, Los Angeles, CA 90095, USA. Email:; Tulane University, James M. Hyman is the Evelyn and John G. Phillips Distinguished Professor in Mathematics in the School of Science and Engineering, New Orleans, United States; National Institute of Allergy and Infectious Diseases, National Institutes of Health, David M. Morens is Senior Advisor to the Director in the Office of the Director, Bethesda, MD 20892, United States; Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Jeffery K. Taubenberger is Chief of the Viral Pathogenesis and Evolution Section, Bethesda, MD 20892, United States; Scott P. Layne is emeritus professor in the Department of Epidemiology, UCLA School of Public Health, Los Angeles, CA 90095, USA. Email: scottplayne@gmail.com; Tulane University, James M. Hyman is the Evelyn and John G. Phillips Distinguished Professor in Mathematics in the School of Science and Engineering, New Orleans, United States; National Institute of Allergy and Infectious Diseases, National Institutes of Health, David M. Morens is Senior Advisor to the Director in the Office of the Director, Bethesda, MD 20892, United States; Scott P. Layne is emeritus professor in the Department of Epidemiology, UCLA School of Public Health, Los Angeles, CA 90095, USA. Email: scottplayne@gmail.com taubenbergerj@niaid.nih.gov; Tulane University, James M. Hyman is the Evelyn and John G. Phillips Distinguished Professor in Mathematics in the School of Science and Engineering, New Orleans, United States; National Institute of Allergy and Infectious Diseases, National Institutes of Health, David M. Morens is Senior Advisor to the Director in the Office of the Director, Bethesda, MD 20892, United States","Layne, S.P., Scott P. Layne is emeritus professor in the Department of Epidemiology, UCLA School of Public Health, Los Angeles, CA 90095, USA. Email:, Tulane University, James M. Hyman is the Evelyn and John G. Phillips Distinguished Professor in Mathematics in the School of Science and Engineering, New Orleans, United States, National Institute of Allergy and Infectious Diseases, National Institutes of Health, David M. Morens is Senior Advisor to the Director in the Office of the Director, Bethesda, MD 20892, United States, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Jeffery K. Taubenberger is Chief of the Viral Pathogenesis and Evolution Section, Bethesda, MD 20892, United States; Hyman, J.M., National Institute of Allergy and Infectious Diseases, National Institutes of Health, David M. Morens is Senior Advisor to the Director in the Office of the Director, Bethesda, MD 20892, United States, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Jeffery K. Taubenberger is Chief of the Viral Pathogenesis and Evolution Section, Bethesda, MD 20892, United States, Scott P. Layne is emeritus professor in the Department of Epidemiology, UCLA School of Public Health, Los Angeles, CA 90095, USA. Email: scottplayne@gmail.com, Tulane University, James M. Hyman is the Evelyn and John G. Phillips Distinguished Professor in Mathematics in the School of Science and Engineering, New Orleans, United States; Morens, D.M., Tulane University, James M. Hyman is the Evelyn and John G. Phillips Distinguished Professor in Mathematics in the School of Science and Engineering, New Orleans, United States, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Jeffery K. Taubenberger is Chief of the Viral Pathogenesis and Evolution Section, Bethesda, MD 20892, United States, Scott P. Layne is emeritus professor in the Department of Epidemiology, UCLA School of Public Health, Los Angeles, CA 90095, USA. Email: scottplayne@gmail.com, National Institute of Allergy and Infectious Diseases, National Institutes of Health, David M. Morens is Senior Advisor to the Director in the Office of the Director, Bethesda, MD 20892, United States; Taubenberger, J.K., Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Jeffery K. Taubenberger is Chief of the Viral Pathogenesis and Evolution Section, Bethesda, MD 20892, United States, Scott P. Layne is emeritus professor in the Department of Epidemiology, UCLA School of Public Health, Los Angeles, CA 90095, USA. Email: scottplayne@gmail.com taubenbergerj@niaid.nih.gov, Tulane University, James M. Hyman is the Evelyn and John G. Phillips Distinguished Professor in Mathematics in the School of Science and Engineering, New Orleans, United States, National Institute of Allergy and Infectious Diseases, National Institutes of Health, David M. Morens is Senior Advisor to the Director in the Office of the Director, Bethesda, MD 20892, United States","We need to understand and quantify the dominant variables that govern the SARS-CoV-2 outbreak, rather than relying exclusively on confirmed cases and their geospatial spread. Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.",,"COVID-19; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; China; Coronavirus infection; epidemiological monitoring; Europe; forecasting; host pathogen interaction; human; information dissemination; pandemic; pathogenicity; public health; quarantine; social status; theoretical model; United States; virus pneumonia; Betacoronavirus; China; Coronavirus Infections; Epidemiological Monitoring; Europe; Forecasting; Host-Pathogen Interactions; Humans; Information Dissemination; Models, Theoretical; Pandemics; Pneumonia, Viral; Public Health; Quarantine; Social Conditions; United States",,,,NLM (Medline),19466242,,,32161107,English,Sci Transl Med,Editorial,Final,Open Access,Scopus,2-s2.0-85081683655,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Sah R., Rodriguez-Morales A.J., Jha R., Chu D.K.W., Gu H., Peiris M., Bastola A., Lal B.K., Ojha H.C., Rabaan A.A., Zambrano L.I., Costello A., Morita K., Pandey B.D., Poon L.L.M.",57195544674;8886801000;57214136920;7201734326;56822842000;57216110042;56204036000;57195329823;57215082208;56049830800;55497039300;36505770400;7403261262;7102018582;7005441747;,Complete genome sequence of a 2019 novel coronavirus (SARS-COV-2) strain isolated in Nepal,2020,Microbiology Resource Announcements,9,11, e00169-20,,,,,10.1128/MRA.00169-20,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082466056&doi=10.1128%2fMRA.00169-20&partnerID=40&md5=483007015e5525c69d7b0c857367f639,"National Public Health Laboratory, Kathmandu, Nepal; Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnologica de Pereira, Pereira, Risaralda, Colombia; Grupo de Investigación Biomedicina, Faculty of Medicine, Fundación Universitaria Autónoma de las Américas, Pereira, Risaralda, Colombia; School of Public Health, LKS Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China; Sukraraj Tropical and Infectious Disease Hospital, Kathmandu, Nepal; Epidemiology and Disease Control Division, Government of Nepal, Kathmandu, Nepal; Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia; Departments of Physiological and Morphological Sciences, School of Medical Sciences, Universidad Nacional Autónoma de Honduras (UNAH), Tegucigalpa, Honduras; Global Health and Sustainable Development, University College London, London, United Kingdom; Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan","Sah, R., National Public Health Laboratory, Kathmandu, Nepal; Rodriguez-Morales, A.J., Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnologica de Pereira, Pereira, Risaralda, Colombia, Grupo de Investigación Biomedicina, Faculty of Medicine, Fundación Universitaria Autónoma de las Américas, Pereira, Risaralda, Colombia; Jha, R., National Public Health Laboratory, Kathmandu, Nepal; Chu, D.K.W., School of Public Health, LKS Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China; Gu, H., School of Public Health, LKS Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China; Peiris, M., School of Public Health, LKS Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China; Bastola, A., Sukraraj Tropical and Infectious Disease Hospital, Kathmandu, Nepal; Lal, B.K., Epidemiology and Disease Control Division, Government of Nepal, Kathmandu, Nepal; Ojha, H.C., Epidemiology and Disease Control Division, Government of Nepal, Kathmandu, Nepal; Rabaan, A.A., Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia; Zambrano, L.I., Departments of Physiological and Morphological Sciences, School of Medical Sciences, Universidad Nacional Autónoma de Honduras (UNAH), Tegucigalpa, Honduras; Costello, A., Global Health and Sustainable Development, University College London, London, United Kingdom; Morita, K., Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan; Pandey, B.D., Sukraraj Tropical and Infectious Disease Hospital, Kathmandu, Nepal; Poon, L.L.M., School of Public Health, LKS Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region, China","A complete genome sequence was obtained for a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) strain isolated from an oropharyngeal swab specimen of a Nepalese patient with coronavirus disease 2019 (COVID-19), who had returned to Nepal after traveling to Wuhan, China. Copyright © 2020 Sah et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.",,,"Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Cao, B., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506. , https://doi.org/10.1016/S0140-6736(20)30183-5; Rodriguez-Morales, A.J., MacGregor, K., Kanagarajah, S., Patel, D., Schlagenhauf, P., Going global: Travel and the 2019 novel coronavirus (2020) Travel Med Infect Dis, 33, p. 101578. , https://doi.org/10.1016/j.tmaid.2020.101578; Rodriguez-Morales, A.J., Bonilla-Aldana, D.K., Balbin-Ramon, G.J., Paniz-Mondolfi, A., Rabaan, A., Sah, R., Pagliano, P., Esposito, S., History is repeating itself, a probable zoonotic spillover as a cause of an epidemic: The case of 2019 novel coronavirus (2020) Infez Med, 28, pp. 3-5; Bastola, A., Sah, R., Rodriguez-Morales, A.J., Lal, B.K., Jha, R., Ojha, H.C., Shrestha, B., Pandey, B.D., The first 2019 novel coronavirus case in Nepal (2020) Lancet Infect Dis, 20, pp. 279-280. , https://doi.org/10.1016/S1473-3099(20)30067-0; Chu, D.K.W., Pan, Y., Cheng, S.M.S., Hui, K.P.Y., Krishnan, P., Liu, Y., Ng, D.Y.M., Poon, L.L.M., Molecular diagnosis of a novel coronavirus (2019-nCoV) causing an outbreak of pneumonia (2020) Clin Chem, , https://doi.org/10.1093/clinchem/hvaa029; Thompson, J.D., Higgins, D.G., Gibson, T.J., Clustal W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice (1994) Nucleic Acids Res, 22, pp. 4673-4680. , https://doi.org/10.1093/nar/22.22.4673; Wisecaver, J.H., Hackett, J.D., The impact of automated filtering of BLAST-determined homologs in the phylogenetic detection of horizontal gene transfer from a transcriptome assembly (2014) Mol Phylogenet Evol, 71, pp. 184-192. , https://doi.org/10.1016/j.ympev.2013.11.016","Sah, R.; National Public Health LaboratoryNepal; email: ranjitsah@iom.edu.np",,American Society for Microbiology,2576098X,,,,English,Micro. Res. Ann,Article,Final,Open Access,Scopus,2-s2.0-85082466056,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhou P., Yang X.-L., Wang X.-G., Hu B., Zhang L., Zhang W., Si H.-R., Zhu Y., Li B., Huang C.-L., Chen H.-D., Chen J., Luo Y., Guo H., Jiang R.-D., Liu M.-Q., Chen Y., Shen X.-R., Wang X., Zheng X.-S., Zhao K., Chen Q.-J., Deng F., Liu L.-L., Yan B., Zhan F.-X., Wang Y.-Y., Xiao G.-F., Shi Z.-L.",56996599500;57214939296;57215676198;55908560200;57215674857;56151953000;57215134494;55723768200;57077269800;57214757309;57215669706;57203334768;57201338288;57202102183;13408601200;57214932647;57215676084;57198428856;57215676200;57198448529;57213476191;57215673993;35847541100;57215668453;57204351774;57214469225;57214940355;8237740300;7403733955;,A pneumonia outbreak associated with a new coronavirus of probable bat origin,2020,Nature,579,7798,,270,273,,128,10.1038/s41586-020-2012-7,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081624816&doi=10.1038%2fs41586-020-2012-7&partnerID=40&md5=cb468d9ac2a240115884c1f298070ca8,"CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Wuhan Jin Yin-Tan Hospital, Wuhan, China; University of Chinese Academy of Sciences, Beijing, China; Hubei Provincial Center for Disease Control and Prevention, Wuhan, China","Zhou, P., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Yang, X.-L., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Wang, X.-G., Wuhan Jin Yin-Tan Hospital, Wuhan, China; Hu, B., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Zhang, L., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Zhang, W., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Si, H.-R., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China, University of Chinese Academy of Sciences, Beijing, China; Zhu, Y., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Li, B., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Huang, C.-L., Wuhan Jin Yin-Tan Hospital, Wuhan, China; Chen, H.-D., Wuhan Jin Yin-Tan Hospital, Wuhan, China; Chen, J., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China, University of Chinese Academy of Sciences, Beijing, China; Luo, Y., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China, University of Chinese Academy of Sciences, Beijing, China; Guo, H., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China, University of Chinese Academy of Sciences, Beijing, China; Jiang, R.-D., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China, University of Chinese Academy of Sciences, Beijing, China; Liu, M.-Q., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China, University of Chinese Academy of Sciences, Beijing, China; Chen, Y., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China, University of Chinese Academy of Sciences, Beijing, China; Shen, X.-R., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China, University of Chinese Academy of Sciences, Beijing, China; Wang, X., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China, University of Chinese Academy of Sciences, Beijing, China; Zheng, X.-S., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China, University of Chinese Academy of Sciences, Beijing, China; Zhao, K., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China, University of Chinese Academy of Sciences, Beijing, China; Chen, Q.-J., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Deng, F., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Liu, L.-L., Hubei Provincial Center for Disease Control and Prevention, Wuhan, China; Yan, B., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Zhan, F.-X., Hubei Provincial Center for Disease Control and Prevention, Wuhan, China; Wang, Y.-Y., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Xiao, G.-F., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China; Shi, Z.-L., CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China","Since the outbreak of severe acute respiratory syndrome (SARS) 18 years ago, a large number of SARS-related coronaviruses (SARSr-CoVs) have been discovered in their natural reservoir host, bats1–4. Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans5–7. Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. The epidemic, which started on 12 December 2019, had caused 2,794 laboratory-confirmed infections including 80 deaths by 26 January 2020. Full-length genome sequences were obtained from five patients at an early stage of the outbreak. The sequences are almost identical and share 79.6% sequence identity to SARS-CoV. Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of SARSr-CoV. In addition, 2019-nCoV virus isolated from the bronchoalveolar lavage fluid of a critically ill patient could be neutralized by sera from several patients. Notably, we confirmed that 2019-nCoV uses the same cell entry receptor—angiotensin converting enzyme II (ACE2)—as SARS-CoV. © 2020, The Author(s).",,"angiotensin converting enzyme 2; viral protein; angiotensin converting enzyme 2; COVID-19; dipeptidyl carboxypeptidase; severe acute respiratory syndrome coronavirus 2; virus antibody; cell; cell component; enzyme; enzyme activity; genome; pneumonia; protein; severe acute respiratory syndrome; virus; amino acid sequence; animal cell; Article; bat; bronchoalveolar lavage fluid; China; clinical article; controlled study; coronavirus disease 2019; critically ill patient; epidemic; high risk population; human; human cell; infection risk; mortality rate; nonhuman; pneumonia; priority journal; protein domain; risk factor; SARS coronavirus; sequence analysis; sequence homology; severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; virus cell interaction; virus characterization; virus detection; virus entry; virus identification; virus isolation; virus neutralization; whole genome sequencing; animal; Betacoronavirus; blood; cell line; Chlorocebus aethiops; classification; Coronavirus infection; female; genetics; male; metabolism; phylogeny; SARS coronavirus; severe acute respiratory syndrome; ultrastructure; Vero cell line; virology; virus genome; virus pneumonia; China; Hubei; Wuhan; Coronavirus; SARS coronavirus; Animals; Antibodies, Viral; Betacoronavirus; Cell Line; China; Chiroptera; Chlorocebus aethiops; Coronavirus Infections; Disease Outbreaks; Female; Genome, Viral; Humans; Male; Peptidyl-Dipeptidase A; Phylogeny; Pneumonia, Viral; SARS Virus; Sequence Homology, Nucleic Acid; Severe Acute Respiratory Syndrome; Vero Cells","Li, W., Bats are natural reservoirs of SARS-like coronaviruses (2005) Science, 310, pp. 676-679. , COI: 1:CAS:528:DC%2BD2MXhtFChsLjO; Ge, X.-Y., Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor (2013) Nature, 503, pp. 535-538. , COI: 1:CAS:528:DC%2BC3sXhslSnsLrF; Yang, L., Novel SARS-like betacoronaviruses in bats, China, 2011 (2013) Emerg. Infect. Dis., 19, pp. 989-991. , PID: 23739658; Hu, B., Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus (2017) PLoS Pathog., 13; Menachery, V.D., A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence (2015) Nat. Med., 21, pp. 1508-1513. , COI: 1:CAS:528:DC%2BC2MXhslKgt7nO; Menachery, V.D., SARS-like WIV1-CoV poised for human emergence (2016) Proc. Natl Acad. Sci. USA, 113, pp. 3048-3053. , COI: 1:CAS:528:DC%2BC28XktV2msr8%3D; Wang, N., Serological evidence of bat SARS-related coronavirus infection in humans, China (2018) Virol. Sin., 33, pp. 104-107; Drosten, C., Identification of a novel coronavirus in patients with severe acute respiratory syndrome (2003) N. Engl. J. Med., 348, pp. 1967-1976. , COI: 1:CAS:528:DC%2BD3sXjslajurw%3D; Zaki, A.M., van Boheemen, S., Bestebroer, T.M., Osterhaus, A.D.M.E., Fouchier, R.A.M., Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia (2012) N. Engl. J. Med., 367, pp. 1814-1820. , COI: 1:CAS:528:DC%2BC38Xhs1ekt73P; Cui, J., Li, F., Shi, Z.L., Origin and evolution of pathogenic coronaviruses (2019) Nat. Rev. Microbiol., 17, pp. 181-192. , COI: 1:CAS:528:DC%2BC1cXisVyhtbnL; Fan, Y., Zhao, K., Shi, Z.-L., Zhou, P., Bat coronaviruses in China (2019) Viruses, 11, p. 210. , COI: 1:CAS:528:DC%2BC1MXhslymtbnL; (2020) Press Statement Related to Novel Coronavirus Infection, , http://wjw.wuhan.gov.cn/front/web/showDetail/2020012709194, in Chinese; Poon, L.L., Identification of a novel coronavirus in bats (2005) J. Virol., 79, pp. 2001-2009. , COI: 1:CAS:528:DC%2BD2MXitlejtrc%3D; Li, W., Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus (2003) Nature, 426, pp. 450-454. , COI: 1:CAS:528:DC%2BD3sXpt1GlsLs%3D; Gorbalenya, A.E., (2020) Severe Acute Respiratory Syndrome-Related Coronavirus — the Species and Its Viruses, a Statement of the Coronavirus Study Group, , https://www.biorxiv.org/content/10.1101/2020.02.07.937862v1; WHO Director-General’s Remarks at the Media Briefing on 2019-Ncov on 11 February 2020, , https://www.who.int/dg/speeches/detail/who-director-general-s-remarks-at-the-media-briefing-on-2019-ncov-on-11-february-2020, WHO, 11 February 2020","Shi, Z.-L.; CAS Key Laboratory of Special Pathogens, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of SciencesChina; email: zlshi@wh.iov.cn",,Nature Research,280836,,NATUA,32015507,English,Nature,Article,Final,Open Access,Scopus,2-s2.0-85081624816,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wu F., Zhao S., Yu B., Chen Y.-M., Wang W., Song Z.-G., Hu Y., Tao Z.-W., Tian J.-H., Pei Y.-Y., Yuan M.-L., Zhang Y.-L., Dai F.-H., Liu Y., Wang Q.-M., Zheng J.-J., Xu L., Holmes E.C., Zhang Y.-Z.",57215708163;57215658236;55272053400;57211131873;57215072926;50263070700;57214754517;57215653821;54879986300;57215653910;57215654893;57215671383;57215673319;57214948410;57215662426;57215653544;57214745607;55535773400;56116316900;,A new coronavirus associated with human respiratory disease in China,2020,Nature,579,7798,,265,269,,46,10.1038/s41586-020-2008-3,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081626097&doi=10.1038%2fs41586-020-2008-3&partnerID=40&md5=689f9f91591479535c9b2ce43850804c,"Shanghai Public Health Clinical Center, Fudan University, Shanghai, China; Department of Pulmonary and Critical Care Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Wuhan Center for Disease Control and Prevention, Wuhan, China; Department of Zoonosis, National Institute for Communicable Disease Control and Prevention, China Center for Disease Control and Prevention, Beijing, China; Marie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and School of Medical Sciences, The University of Sydney, Sydney, NSW, Australia; School of Public Health, Fudan University, Shanghai, China","Wu, F., Shanghai Public Health Clinical Center, Fudan University, Shanghai, China; Zhao, S., Department of Pulmonary and Critical Care Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Yu, B., Wuhan Center for Disease Control and Prevention, Wuhan, China; Chen, Y.-M., Shanghai Public Health Clinical Center, Fudan University, Shanghai, China; Wang, W., Department of Zoonosis, National Institute for Communicable Disease Control and Prevention, China Center for Disease Control and Prevention, Beijing, China; Song, Z.-G., Shanghai Public Health Clinical Center, Fudan University, Shanghai, China; Hu, Y., Department of Pulmonary and Critical Care Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Tao, Z.-W., Department of Pulmonary and Critical Care Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Tian, J.-H., Wuhan Center for Disease Control and Prevention, Wuhan, China; Pei, Y.-Y., Shanghai Public Health Clinical Center, Fudan University, Shanghai, China; Yuan, M.-L., Department of Pulmonary and Critical Care Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Zhang, Y.-L., Shanghai Public Health Clinical Center, Fudan University, Shanghai, China; Dai, F.-H., Shanghai Public Health Clinical Center, Fudan University, Shanghai, China; Liu, Y., Shanghai Public Health Clinical Center, Fudan University, Shanghai, China; Wang, Q.-M., Shanghai Public Health Clinical Center, Fudan University, Shanghai, China; Zheng, J.-J., Shanghai Public Health Clinical Center, Fudan University, Shanghai, China; Xu, L., Shanghai Public Health Clinical Center, Fudan University, Shanghai, China; Holmes, E.C., Shanghai Public Health Clinical Center, Fudan University, Shanghai, China, Marie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and School of Medical Sciences, The University of Sydney, Sydney, NSW, Australia; Zhang, Y.-Z., Shanghai Public Health Clinical Center, Fudan University, Shanghai, China, Department of Zoonosis, National Institute for Communicable Disease Control and Prevention, China Center for Disease Control and Prevention, Beijing, China, School of Public Health, Fudan University, Shanghai, China","Emerging infectious diseases, such as severe acute respiratory syndrome (SARS) and Zika virus disease, present a major threat to public health1–3. Despite intense research efforts, how, when and where new diseases appear are still a source of considerable uncertainty. A severe respiratory disease was recently reported in Wuhan, Hubei province, China. As of 25 January 2020, at least 1,975 cases had been reported since the first patient was hospitalized on 12 December 2019. Epidemiological investigations have suggested that the outbreak was associated with a seafood market in Wuhan. Here we study a single patient who was a worker at the market and who was admitted to the Central Hospital of Wuhan on 26 December 2019 while experiencing a severe respiratory syndrome that included fever, dizziness and a cough. Metagenomic RNA sequencing4 of a sample of bronchoalveolar lavage fluid from the patient identified a new RNA virus strain from the family Coronaviridae, which is designated here ‘WH-Human 1’ coronavirus (and has also been referred to as ‘2019-nCoV’). Phylogenetic analysis of the complete viral genome (29,903 nucleotides) revealed that the virus was most closely related (89.1% nucleotide similarity) to a group of SARS-like coronaviruses (genus Betacoronavirus, subgenus Sarbecovirus) that had previously been found in bats in China5. This outbreak highlights the ongoing ability of viral spill-over from animals to cause severe disease in humans. © 2020, The Author(s).",,"antibiotic agent; antivirus agent; aspartate aminotransferase; creatine kinase; genomic RNA; glucocorticoid; lactate dehydrogenase; nucleotide; virus RNA; COVID-19; severe acute respiratory syndrome coronavirus 2; virus RNA; disease prevalence; epidemiology; genome; hospital sector; infectious disease; phylogenetics; public health; respiratory disease; severe acute respiratory syndrome; uncertainty analysis; virus; adult; arterial gas; Article; Betacoronavirus; bronchoalveolar lavage fluid; case report; chest tightness; China; clinical article; computer assisted tomography; Coronaviridae; coronavirus disease 2019; Coronavirus infection; coughing; diabetes mellitus; disease severity; dizziness; fever; hepatitis; hospital admission; human; human cell; hypoxemia; male; metagenomics; nonhuman; noninvasive ventilation; nucleotide sequence; pain; phylogeny; physical examination; priority journal; real time polymerase chain reaction; respiratory failure; reverse transcription polymerase chain reaction; RNA extraction; RNA sequencing; RNA virus; SARS coronavirus; severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; thorax radiography; tuberculosis; virus genome; virus identification; virus isolation; virus strain; weakness; classification; communicable disease; complication; Coronavirus infection; diagnostic imaging; genetic recombination; genetics; lung; pathology; severe acute respiratory syndrome; virology; virus pneumonia; whole genome sequencing; x-ray computed tomography; China; Hubei; Wuhan; Animalia; Coronaviridae; Coronavirus; RNA viruses; Zika virus; Adult; Betacoronavirus; China; Communicable Diseases, Emerging; Coronavirus Infections; Genome, Viral; Humans; Lung; Male; Phylogeny; Pneumonia, Viral; Recombination, Genetic; RNA, Viral; Severe Acute Respiratory Syndrome; Tomography, X-Ray Computed; Whole Genome Sequencing","Drosten, C., Identification of a novel coronavirus in patients with severe acute respiratory syndrome (2003) N. 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Chem., 281, pp. 34610-34616. , COI: 1:CAS:528:DC%2BD28XhtFKgurzE","Zhang, Y.-Z.; Shanghai Public Health Clinical Center, Fudan UniversityChina; email: zhangyongzhen@shphc.org.cn",,Nature Research,280836,,NATUA,32015508,English,Nature,Article,Final,Open Access,Scopus,2-s2.0-85081626097,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Pongpirul W.A., Pongpirul K., Ratnarathon A.C., Prasithsirikul W.",56073339000;14720203700;57215773547;14032276000;,Journey of a Thai Taxi driver and novel coronavirus,2020,New England Journal of Medicine,382,11,,1067,1068,,5,10.1056/NEJMc2001621,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080931731&doi=10.1056%2fNEJMc2001621&partnerID=40&md5=e15c781196291227a0558fc673fccb33,"Bamrasnaradura Infectious Diseases Institute, Nonthaburi, Thailand; Chulalongkorn University, Bangkok, Thailand","Pongpirul, W.A., Bamrasnaradura Infectious Diseases Institute, Nonthaburi, Thailand; Pongpirul, K., Chulalongkorn University, Bangkok, Thailand; Ratnarathon, A.C., Bamrasnaradura Infectious Diseases Institute, Nonthaburi, Thailand; Prasithsirikul, W., Bamrasnaradura Infectious Diseases Institute, Nonthaburi, Thailand",[No abstract available],,"2019 novel coronavirus; adult; case report; Chinese; clinical article; Coronavirinae; coughing; dyspnea; fever; hospital admission; hospital discharge; human; human tissue; hypertension; Letter; lung infiltrate; male; middle aged; myalgia; non insulin dependent diabetes mellitus; nonmedical occupations; patient isolation; patient referral; prescription; priority journal; real time reverse transcription polymerase chain reaction; SARS coronavirus; severe acute respiratory syndrome; taxi driver; Thai (people); Thailand; thorax radiography; throat culture; tourism; Betacoronavirus; China; complication; Coronavirus infection; dyspnea; fever; genetics; isolation and purification; occupational exposure; traffic and transport; travel; virus pneumonia; COVID-19; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; China; Coronavirus Infections; Dyspnea; Fever; Humans; Male; Middle Aged; Occupational Exposure; Pneumonia, Viral; Thailand; Transportation; Travel","Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia N Engl J Med.; Rothe, C., Schunk, M., Sothmann, P., Transmission of 2019-nCoV infection from an asymptomatic contact in Germany (2020) N Engl J Med, 383, pp. 970-971","Pongpirul, K.; Chulalongkorn UniversityThailand; email: doctorkrit@gmail.com",,Massachussetts Medical Society,284793,,NEJMA,32050060,English,New Engl. J. Med.,Letter,Final,Open Access,Scopus,2-s2.0-85080931731,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Guo Y.-R., Cao Q.-D., Hong Z.-S., Tan Y.-Y., Chen S.-D., Jin H.-J., Tan K.-S., Wang D.-Y., Yan Y.",57215852469;57205391700;57215854014;57215852263;57215851932;57215852436;57205074420;57214941259;57214767992;,"The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status",2020,Military Medical Research,7,1,,11,,,,10.1186/s40779-020-00240-0,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082093259&doi=10.1186%2fs40779-020-00240-0&partnerID=40&md5=2ef445be15dce7e706a38e9e6a621380,"Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging, Zhuhai, Guangdong 519000, China; Department of Cardiothoracic Surgery, Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai, Guangdong 519000, China; Center of Infectious Disease, Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai, Guangdong 519000, China; Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System119228, Singapore; Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System119228, Singapore; Center for Interventional Medicine, Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai, Guangdong 519000, China","Guo, Y.-R., Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging, Zhuhai, Guangdong 519000, China; Cao, Q.-D., Department of Cardiothoracic Surgery, Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai, Guangdong 519000, China; Hong, Z.-S., Center of Infectious Disease, Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai, Guangdong 519000, China; Tan, Y.-Y., Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging, Zhuhai, Guangdong 519000, China; Chen, S.-D., Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging, Zhuhai, Guangdong 519000, China; Jin, H.-J., Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging, Zhuhai, Guangdong 519000, China; Tan, K.-S., Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System119228, Singapore; Wang, D.-Y., Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System119228, Singapore; Yan, Y., Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging, Zhuhai, Guangdong 519000, China, Center for Interventional Medicine, Fifth Affiliated Hospital, Sun Yat-Sen University, Zhuhai, Guangdong 519000, China","An acute respiratory disease, caused by a novel coronavirus (SARS-CoV-2, previously known as 2019-nCoV), the coronavirus disease 2019 (COVID-19) has spread throughout China and received worldwide attention. On 30 January 2020, World Health Organization (WHO) officially declared the COVID-19 epidemic as a public health emergency of international concern. The emergence of SARS-CoV-2, since the severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002 and Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, marked the third introduction of a highly pathogenic and large-scale epidemic coronavirus into the human population in the twenty-first century. As of 1 March 2020, a total of 87,137 confirmed cases globally, 79,968 confirmed in China and 7169 outside of China, with 2977 deaths (3.4%) had been reported by WHO. Meanwhile, several independent research groups have identified that SARS-CoV-2 belongs to β-coronavirus, with highly identical genome to bat coronavirus, pointing to bat as the natural host. The novel coronavirus uses the same receptor, angiotensin-converting enzyme 2 (ACE2) as that for SARS-CoV, and mainly spreads through the respiratory tract. Importantly, increasingly evidence showed sustained human-to-human transmission, along with many exported cases across the globe. The clinical symptoms of COVID-19 patients include fever, cough, fatigue and a small population of patients appeared gastrointestinal infection symptoms. The elderly and people with underlying diseases are susceptible to infection and prone to serious outcomes, which may be associated with acute respiratory distress syndrome (ARDS) and cytokine storm. Currently, there are few specific antiviral strategies, but several potent candidates of antivirals and repurposed drugs are under urgent investigation. In this review, we summarized the latest research progress of the epidemiology, pathogenesis, and clinical characteristics of COVID-19, and discussed the current treatment and scientific advancements to combat the epidemic novel coronavirus.",Clinical characteristics; Coronavirus disease 2019 (COVID-19); Origin; SARS-CoV-2; Therapy; Transmission,"angiotensin converting enzyme 2; COVID-19; dipeptidyl carboxypeptidase; severe acute respiratory syndrome coronavirus 2; virus envelope protein; adult; aged; Alphacoronavirus; animal; bat; Betacoronavirus; China; Coronavirus infection; coughing; diarrhea; disease carrier; epidemic; fatigue; female; fever; genetics; human; male; middle aged; Middle East respiratory syndrome coronavirus; pathogenicity; SARS coronavirus; virulence; virus pneumonia; virus replication; Adult; Aged; Alphacoronavirus; Animals; Betacoronavirus; China; Chiroptera; Coronavirus Infections; Cough; Diarrhea; Disease Outbreaks; Disease Reservoirs; Fatigue; Female; Fever; Humans; Male; Middle Aged; Middle East Respiratory Syndrome Coronavirus; Peptidyl-Dipeptidase A; Pneumonia, Viral; SARS Virus; Viral Envelope Proteins; Virulence; Virus Replication",,,,NLM (Medline),20549369,,,32169119,English,Mil Med Res,Review,Final,Open Access,Scopus,2-s2.0-85082093259,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Batlle D., Wysocki J., Satchell K.",7006639571;8324475200;26638445900;,Soluble angiotensin-converting enzyme 2: a potential approach for coronavirus infection therapy?,2020,"Clinical science (London, England : 1979)",134,5,,543,545,,,10.1042/CS20200163,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081902597&doi=10.1042%2fCS20200163&partnerID=40&md5=7dd863a05a549d00bc6cfd749299d9e8,"Department of Medicine/ Division of Nephrology/Hypertension, Northwestern University Feinberg School of Medicine, Chicago, United States; Department Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, United States; Center for Structural Genomics of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, United States","Batlle, D., Department of Medicine/ Division of Nephrology/Hypertension, Northwestern University Feinberg School of Medicine, Chicago, United States; Wysocki, J., Department of Medicine/ Division of Nephrology/Hypertension, Northwestern University Feinberg School of Medicine, Chicago, United States; Satchell, K., Department Microbiology-Immunology, Northwestern University Feinberg School of Medicine, Chicago, United States, Center for Structural Genomics of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, United States","A new coronavirus, referred to as SARS-CoV-2, is responsible for the recent outbreak of severe respiratory disease. This outbreak first detected in Wuhan, China in December 2019, has spread to other regions of China and to 25 other countries as of January, 2020. It has been known since the 2003 SARS epidemic that the receptor critical for SARS-CoV entry into host cells is the angiotensin-converting enzyme 2 (ACE2). The S1 domain of the spike protein of SARS-CoV attaches the virus to its cellular receptor ACE2 on the host cells. We thought that it is timely to explain the connection between the SARS-CoV, SARS-CoV-2, ACE2 and the rationale for soluble ACE2 as a potential therapy. © 2020 The Author(s).",2019 Novel Coronavirus; angiotensin converting enzyme 2; Coronavirus,"angiotensin converting enzyme 2; COVID-19; dipeptidyl carboxypeptidase; recombinant protein; severe acute respiratory syndrome coronavirus 2; animal; Betacoronavirus; cell line; Coronavirus infection; Haplorhini; human; pathogenicity; physiology; SARS coronavirus; solubility; virus attachment; virus pneumonia; virus replication; Animals; Betacoronavirus; Cell Line; Coronavirus Infections; Haplorhini; Humans; Peptidyl-Dipeptidase A; Pneumonia, Viral; Recombinant Proteins; SARS Virus; Solubility; Virus Attachment; Virus Replication",,,,NLM (Medline),14708736,,,32167153,English,Clin. Sci.,Letter,Final,Open Access,Scopus,2-s2.0-85081902597,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhao S., Zhuang Z., Cao P., Ran J., Gao D., Lou Y., Yang L., Cai Y., Wang W., He D., Wang M.H.",57215864100;57215413912;57215190886;57215433897;38861547100;16417276600;57215863748;57215864165;57215863939;7403045834;57215863971;,"Quantifying the association between domestic travel and the exportation of novel coronavirus (2019-nCoV) cases from Wuhan, China in 2020: a correlational analysis",2020,Journal of travel medicine,27,2,,,,,,10.1093/jtm/taaa022,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082143183&doi=10.1093%2fjtm%2ftaaa022&partnerID=40&md5=c5c67e15513661be4eddf9b41b736b67,"JC School of Public Health and Primary Care, Chinese University of Hong Kong, Hong Kong, China; Shenzhen Research Institute of Chinese University of Hong Kong, Shenzhen, China; Department of Applied Mathematics, Hong Kong Polytechnic University, Hong Kong, China; Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China; School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China; Mathematics and Science College, Shanghai Normal UniversityShanghai, China; School of Nursing, Hong Kong Polytechnic University, Hong Kong, China; Department of Mathematics, Huaiyin Normal University, Huai'an, China","Zhao, S., JC School of Public Health and Primary Care, Chinese University of Hong Kong, Hong Kong, China, Shenzhen Research Institute of Chinese University of Hong Kong, Shenzhen, China; Zhuang, Z., Department of Applied Mathematics, Hong Kong Polytechnic University, Hong Kong, China; Cao, P., Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China; Ran, J., School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China; Gao, D., Mathematics and Science College, Shanghai Normal UniversityShanghai, China; Lou, Y., Department of Applied Mathematics, Hong Kong Polytechnic University, Hong Kong, China; Yang, L., School of Nursing, Hong Kong Polytechnic University, Hong Kong, China; Cai, Y., Department of Mathematics, Huaiyin Normal University, Huai'an, China; Wang, W., Department of Mathematics, Huaiyin Normal University, Huai'an, China; He, D., Department of Applied Mathematics, Hong Kong Polytechnic University, Hong Kong, China; Wang, M.H., JC School of Public Health and Primary Care, Chinese University of Hong Kong, Hong Kong, China, Shenzhen Research Institute of Chinese University of Hong Kong, Shenzhen, China",[No abstract available],,"COVID-19; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; China; cluster analysis; Coronavirus infection; disease transmission; human; pathogenicity; physiology; travel; virus pneumonia; Betacoronavirus; China; Cluster Analysis; Coronavirus Infections; Correlation of Data; Disease Transmission, Infectious; Humans; Pneumonia, Viral; Travel",,,,NLM (Medline),17088305,,,32080723,English,J Travel Med,Article,Final,Open Access,Scopus,2-s2.0-85082143183,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Kupferschmidt K.,37095697200;,Genome analyses help track coronavirus' moves,2020,Science,367,6483,,1176,1177,,,10.1126/science.367.6483.1177,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081921466&doi=10.1126%2fscience.367.6483.1177&partnerID=40&md5=a9676980decf653bc00de2f70faaf9de,,"Kupferschmidt, K.",[No abstract available],,genetic analysis; genome; virus; China; Coronavirinae; disease transmission; epidemic; gene mutation; genetic variability; genome analysis; human; infection control; infection prevention; Italy; nonhuman; phylogenetic tree; population research; priority journal; quarantine; SARS-related coronavirus; Short Survey; virus genome; Coronavirus,,,,American Association for the Advancement of Science,368075,,SCIEA,32165563,English,Sci.,Short Survey,Final,,Scopus,2-s2.0-85081921466,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Liu Y., Gayle A.A., Wilder-Smith A., Rocklöv J.",57213171387;57215863792;35509574300;18038015300;,The reproductive number of COVID-19 is higher compared to SARS coronavirus,2020,Journal of travel medicine,27,2,,,,,7,10.1093/jtm/taaa021,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081620476&doi=10.1093%2fjtm%2ftaaa021&partnerID=40&md5=86d5c78105eada22ecb916af275b34db,"School of International Business, Xiamen University Tan Kah Kee College, Zhangzhou, 363105, China; Department of Public Health and Clinical Medicine, Section of Sustainable Health, Umeå University, SE-90187 Umeå, Sweden; Heidelberg Institute of Public Health, Heidelberg, 69120, Germany; Department of Epidemiology and Global Health, Umeå University, SE-90187 Umeå, Sweden","Liu, Y., School of International Business, Xiamen University Tan Kah Kee College, Zhangzhou, 363105, China; Gayle, A.A., Department of Public Health and Clinical Medicine, Section of Sustainable Health, Umeå University, SE-90187 Umeå, Sweden; Wilder-Smith, A., Heidelberg Institute of Public Health, Heidelberg, 69120, Germany, Department of Epidemiology and Global Health, Umeå University, SE-90187 Umeå, Sweden; Rocklöv, J., Department of Public Health and Clinical Medicine, Section of Sustainable Health, Umeå University, SE-90187 Umeå, Sweden",[No abstract available],R 0; China; Coronavirus; COVID-19; Epidemic potential; Public health emergency of international concern; SARS; Wuhan,"COVID-19; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; Coronavirus infection; disease transmission; growth, development and aging; human; incubation time; international cooperation; pathogenicity; physiology; SARS coronavirus; travel; virology; virus load; virus pneumonia; virus replication; Betacoronavirus; Coronavirus Infections; Disease Transmission, Infectious; Humans; Infectious Disease Incubation Period; Internationality; Pneumonia, Viral; SARS Virus; Travel; Viral Load; Virus Replication",,,,NLM (Medline),17088305,,,32052846,English,J Travel Med,Review,Final,Open Access,Scopus,2-s2.0-85081620476,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wilder-Smith A., Freedman D.O.",35509574300;7201528727;,"Isolation, quarantine, social distancing and community containment: pivotal role for old-style public health measures in the novel coronavirus (2019-nCoV) outbreak",2020,Journal of travel medicine,27,2,,,,,4,10.1093/jtm/taaa020,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081333164&doi=10.1093%2fjtm%2ftaaa020&partnerID=40&md5=933f0347e1f61729b2c1c87485d0f5fd,"Department of Disease Control, London School of Hygiene and Tropical Medicine, Keppel St, Bloomsbury, London WC1E 7HT, UK; Heidelberg Institute of Global Health, University of Heidelberg, Seminarstraße 2, Heidelberg, 69117, Germany; University of Alabama, Tuscaloosa, AL 35487, USA","Wilder-Smith, A., Department of Disease Control, London School of Hygiene and Tropical Medicine, Keppel St, Bloomsbury, London WC1E 7HT, UK, Heidelberg Institute of Global Health, University of Heidelberg, Seminarstraße 2, Heidelberg, 69117, Germany; Freedman, D.O., University of Alabama, Tuscaloosa, AL 35487, USA",[No abstract available],coronavirus; COVID-19; MERS; pandemic preparedness; SARS; Wuhan,"COVID-19; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; China; Coronavirus infection; disease transmission; human; patient isolation; prevention and control; public health; quarantine; virus pneumonia; vulnerable population; Betacoronavirus; China; Coronavirus Infections; Disease Transmission, Infectious; Humans; Patient Isolation; Pneumonia, Viral; Public Health; Quarantine; Vulnerable Populations",,,,NLM (Medline),17088305,,,32052841,English,J Travel Med,Article,Final,Open Access,Scopus,2-s2.0-85081333164,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Trilla A.,35485787100;,"One world, one health: The novel coronavirus COVID-19 epidemic [Un mundo, una salud: la epidemia por el nuevo coronavirus COVID-19]",2020,Medicina Clinica,154,5,,175,177,,,10.1016/j.medcli.2020.02.002,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079904159&doi=10.1016%2fj.medcli.2020.02.002&partnerID=40&md5=e6c850b66da09353434ab0151a9a0da6,"Hospital Clínic de Barcelona, Universidad de Barcelona, ISGlobal, Barcelona, Spain","Trilla, A., Hospital Clínic de Barcelona, Universidad de Barcelona, ISGlobal, Barcelona, Spain",[No abstract available],,"2019 novel coronavirus; Article; Coronavirinae; coronavirus disease 2019; Coronavirus infection; epidemic; global health; human; nonhuman; Betacoronavirus; China; civil defense; Coronavirus infection; genetics; international cooperation; pathogenicity; public health; virus pneumonia; COVID-19; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; China; Civil Defense; Coronavirus Infections; Global Health; Humans; Internationality; Pneumonia, Viral; Public Health","Lu, R., Zhao, X., Li, J., Niu, P., Yang, B., Wu, H., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet.; Callaway, E., Cyranoski, D., What scientists want to know about the coronavirus outbreak (2020) Nature., 577, pp. 605-607; Cohen, J., Wuhan seafood market may not be the source of novel virus spreading globally (2020) Science.; Wu, J.Y., Leung, K., Leung, G.M., Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan China: a modelling study (2020) Lancet.; https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200204-sitrep-15-ncov.pdf?sfvrsn=88fe8ad6_2, WHO. Novel Coronavirus (2019-nCoV) Situation Report 15 [consultado 4 Feb 2020]. Disponible en:; Rothe, C., Schunk, M., Sothmann, P., Bretzel, G., Froeschl, G., Wallrauch, C., Transmission of 2019-nCoV infection from an asymptomatic contact in Germany (2020) N Engl J Med.; Kupferschmidt, K., Study claiming new coronavirus can be transmitted by people without symptoms was flawed (2020) Science.; https://www.mscbs.gob.es/profesionales/saludPublica/ccayes/alertasActual/nCov-China/home.htm, Ministerio de Sanidad. Neumonía por un nuevo coronavirus (2019-nCov) en China [consultado 4 Feb 2020]. Disponible en:; https://www.ecdc.europa.eu/en/novel-coronavirus-china, European Centre for Disease Prevention and Control (ECDC). Novel coronavirus [consultado 4 Feb 2020]. Disponible en:; https://www.cdc.gov/coronavirus/2019-ncov/index.html, Centers for Disease Control and Prevention (CDC). 2019 Novel Coronavirus [consultado 4 Feb 2020]. Disponible en:; https://www.who.int/es/health-topics/coronavirus/coronavirus, OMS. Coronavirus [consultado 4 Feb 2020]. Disponible en:; Zhu, N., Zhang, D., Wang, W., Xingwang, L., Yang, B., Song, J., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med.; Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Early transmission dynamics in Wuhan, China, of novel coronavirus – infected pneumonia (2020) N Engl J Med.; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with novel Coronavirus in Wuhan (2020) Lancet; Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan China: a descriptive study (2020) Lancet.; https://www.eiu.com/topic/democracy-index, The Economist Intelligence Unit. Democracy Index 2019 [consultado 4 Feb 2020]. Disponible en:; Pullano, G., Pinotti, F., Valdano, E., Boelle, P.Y., Poletto, C., Colizza, V., Novel coronavirus (2019-nCoV) early-stage importation risk to Europe (2020) Eurosurveillance., 25; Munster, V.J., Koopmans, M., van Doremalen, N., van Riel, D., de Wit, E., A novel coronavirus emerging in China - Key questions for impact assessment (2020) N Engl J Med.; Paules, C.I., Marston, H.D., Fauci, A.S., Coronavirus infections – More than just the common cold (2020) JAMA.; Perlman, S., Another decade, another coronavirus (2020) N Engl J Med.",,,"Ediciones Doyma, S.L.",257753,,MCLBA,32093921,English; Spanish,Med. Clin.,Article,Final,Open Access,Scopus,2-s2.0-85079904159,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Bogoch I.I., Watts A., Thomas-Bachli A., Huber C., Kraemer M.U.G., Khan K.",6506268396;57055024700;54883968300;57201339083;56308225600;35275226600;,Potential for global spread of a novel coronavirus from China,2020,Journal of travel medicine,27,2,,,,,6,10.1093/jtm/taaa011,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079156775&doi=10.1093%2fjtm%2ftaaa011&partnerID=40&md5=d1bfd5ff110e4b39ca307c1dbeb96a1e,"Department of Medicine, University of Toronto, Toronto, ON, Canada; Divisions of General Internal Medicine and Infectious Diseases, University Health Network, Toronto, ON, Canada; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada; Toronto, ON, Canada; Department of Zoology, University of Oxford, Oxford, United Kingdom; Centre for the Mathematical Modelling of Infectious Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom","Bogoch, I.I., Department of Medicine, University of Toronto, Toronto, ON, Canada, Divisions of General Internal Medicine and Infectious Diseases, University Health Network, Toronto, ON, Canada; Watts, A., Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada, Toronto, ON, Canada; Thomas-Bachli, A., Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada, Toronto, ON, Canada; Huber, C., Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada, Toronto, ON, Canada; Kraemer, M.U.G., Department of Zoology, University of Oxford, Oxford, United Kingdom, Centre for the Mathematical Modelling of Infectious Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom; Khan, K., Department of Medicine, University of Toronto, Toronto, ON, Canada, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada, Toronto, ON, Canada",[No abstract available],coronavirus; outbreak; pneumonia; SARS; travel; Wuhan; zoonosis,"COVID-19; severe acute respiratory syndrome coronavirus 2; animal; aviation; Betacoronavirus; China; contact examination; Coronavirus infection; epidemic; global health; human; isolation and purification; public health; travel; veterinary medicine; virology; virus pneumonia; zoonosis; Air Travel; Animals; Betacoronavirus; China; Contact Tracing; Coronavirus Infections; Disease Outbreaks; Global Health; Humans; Pneumonia, Viral; Public Health; Travel; Zoonoses",,,,NLM (Medline),17088305,,,31985790,English,J Travel Med,Article,Final,Open Access,Scopus,2-s2.0-85079156775,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wilson M.E., Chen L.H.",57193196232;57215863940;,Travellers give wings to novel coronavirus (2019-nCoV),2020,Journal of travel medicine,27,2,,,,,4,10.1093/jtm/taaa015,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079137326&doi=10.1093%2fjtm%2ftaaa015&partnerID=40&md5=efae89a5482d17a425108a627829bf2b,"School of Medicine, University of California, Mission Hall, 550 16th St, San Francisco; Department of Global Health and Population, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA 02115, United States; Travel Medicine Center, Mount Auburn Hospital, 330 Mt Auburn St, Cambridge, MA 02138, United States; Harvard Medical School, 25 Shattuck St, Boston, MA 02115, United States","Wilson, M.E., School of Medicine, University of California, Mission Hall, 550 16th St, San Francisco, Department of Global Health and Population, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA 02115, United States; Chen, L.H., Travel Medicine Center, Mount Auburn Hospital, 330 Mt Auburn St, Cambridge, MA 02138, United States, Harvard Medical School, 25 Shattuck St, Boston, MA 02115, United States",[No abstract available],airborne; bats; cross-species spread; live animal markets; MERS; novel coronavirus; one health; respiratory; SARS; spillover; super-spreader; Wuhan,"COVID-19; severe acute respiratory syndrome coronavirus 2; animal; aviation; Betacoronavirus; China; cluster analysis; Coronavirus infection; disease transmission; epidemiology; genetics; human; isolation and purification; male; mortality; pandemic; pathogenicity; veterinary medicine; virology; virus pneumonia; zoonosis; Air Travel; Animals; Betacoronavirus; China; Cluster Analysis; Coronavirus Infections; Disease Transmission, Infectious; Humans; Male; Mortality; Pandemics; Pneumonia, Viral; Zoonoses",,,,NLM (Medline),17088305,,,32010938,English,J Travel Med,Editorial,Final,Open Access,Scopus,2-s2.0-85079137326,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wrapp D., Wang N., Corbett K.S., Goldsmith J.A., Hsieh C.-L., Abiona O., Graham B.S., McLellan J.S.",57189031611;55782500200;36500702900;57215770803;57215777310;57205220353;7201610365;11140034400;,Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation,2020,Science,367,6483,,1260,1263,,10,10.1126/science.aax0902,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081889457&doi=10.1126%2fscience.aax0902&partnerID=40&md5=4f6b0cd6bcc5ff5d73415c13ce8efd4b,"Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, United States; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, United States","Wrapp, D., Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, United States; Wang, N., Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, United States; Corbett, K.S., Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, United States; Goldsmith, J.A., Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, United States; Hsieh, C.-L., Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, United States; Abiona, O., Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, United States; Graham, B.S., Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, United States; McLellan, J.S., Department of Molecular Biosciences, University of Texas at Austin, Austin, TX 78712, United States","The outbreak of a novel coronavirus (2019-nCoV) represents a pandemic threat that has been declared a public health emergency of international concern. The CoV spike (S) glycoprotein is a key target for vaccines, therapeutic antibodies, and diagnostics. To facilitate medical countermeasure development, we determined a 3.5-angstrom-resolution cryo-electron microscopy structure of the 2019-nCoV S trimer in the prefusion conformation. The predominant state of the trimer has one of the three receptor-binding domains (RBDs) rotated up in a receptor-accessible conformation. We also provide biophysical and structural evidence that the 2019-nCoV S protein binds angiotensin-converting enzyme 2 (ACE2) with higher affinity than does severe acute respiratory syndrome (SARS)-CoV S. Additionally, we tested several published SARS-CoV RBD-specific monoclonal antibodies and found that they do not have appreciable binding to 2019-nCoV S, suggesting that antibody cross-reactivity may be limited between the two RBDs. The structure of 2019-nCoV S should enable the rapid development and evaluation of medical countermeasures to address the ongoing public health crisis. © 2020 American Association for the Advancement of Science. All rights reserved.",,"2019 nCoV S protein; angiotensin converting enzyme 2; unclassified drug; viral protein; angiotensin converting enzyme 2; coronavirus spike glycoprotein; dipeptidyl carboxypeptidase; monoclonal antibody; protein binding; severe acute respiratory syndrome coronavirus 2; virus antibody; virus receptor; antibody; detection method; electron microscopy; protein; public health; severe acute respiratory syndrome; virus; Article; binding affinity; biophysics; corona virus disease 2019; Coronavirus infection; cross reaction; cryoelectron microscopy; molecular dynamics; nonhuman; priority journal; protein binding; protein structure; SARS coronavirus; virus transmission; virus virulence; Betacoronavirus; chemistry; cryoelectron microscopy; image processing; immunology; metabolism; molecular model; protein conformation; protein domain; protein multimerization; ultrastructure; Coronavirus; SARS coronavirus; Antibodies, Monoclonal; Antibodies, Viral; Betacoronavirus; Cross Reactions; Cryoelectron Microscopy; Image Processing, Computer-Assisted; Models, Molecular; Peptidyl-Dipeptidase A; Protein Binding; Protein Conformation; Protein Domains; Protein Multimerization; Receptors, Virus; SARS Virus; Spike Glycoprotein, Coronavirus","Chan, J.F., (2020) Lancet, 395, pp. 514-523; Huang, C., (2020) Lancet, 395, pp. 497-506; Lu, R., (2020) Lancet; Wu, F., (2020) Nature; Chen, N., (2020) Lancet, pp. 507-513; Li, Q., (2020) N. Engl. J. Med. NEJMoa2001316; Li, F., (2016) Annu. Rev. Virol., 3, pp. 237-261; Bosch, B.J., Van Der Zee, R., De Haan, C.A., Rottier, P.J., (2003) J. Virol., 77, pp. 8801-8811; Walls, A.C., (2017) Proc. Natl. Acad. Sci. U.S.A., 114, pp. 11157-11162; Gui, M., (2017) Cell Res., 27, pp. 119-129; Pallesen, J., (2017) Proc. Natl. Acad. Sci. U.S.A., 114, pp. E7348-E7357; Walls, A.C., (2019) Cell, 176, pp. 1026e15-1039e15; Yuan, Y., (2017) Nat. Commun., 8, p. 15092; Kirchdoerfer, R.N., (2018) Sci. Rep., 8, p. 15701; Punjani, A., Rubinstein, J.L., Fleet, D.J., Brubaker, M.A., (2017) Nat. Methods, 14, pp. 290-296; Wrapp, D., McLellan, J.S., (2019) J. Virol., 93, pp. e00923-e001019; Walls, A.C., (2016) Nat. Struct. Mol. Biol., 23, pp. 899-905; Kirchdoerfer, R.N., (2016) Nature, 531, pp. 118-121; Coutard, B., (2020) Antiviral Res., 176, p. 104742; Bosch, B.J., Bartelink, W., Rottier, P.J., (2008) J. Virol., 82, pp. 8887-8890; Glowacka, I., (2011) J. Virol., 85, pp. 4122-4134; Li, W., (2003) Nature, 426, pp. 450-454; Belouzard, S., Chu, V.C., Whittaker, G.R., (2009) Proc. Natl. Acad. Sci. U.S.A., 106, pp. 5871-5876; Chen, J., (1998) Cell, 95, pp. 409-417; Hoffmann, M., (2020) The Novel Coronavirus 2019 (2019-nCoV) Uses the SARS-coronavirus Receptor ACE2 and the Cellular Protease TMPRSS2 for Entry into Target Cells, p. 929042. , bioRxiv [Preprint]. 31 January; Wan, Y., Shang, J., Graham, R., Baric, R.S., Li, F., (2020) J. Virol. JVI., pp. 00127-00220; Zhou, P., (2020) Nature; Song, W., Gui, M., Wang, X., Xiang, Y., (2018) PLOS Pathog., 14, p. e1007236; Hwang, W.C., (2006) J. Biol. Chem., 281, pp. 34610-34616; Prabakaran, P., (2006) J. Biol. Chem., 281, pp. 15829-15836; Tian, X., (2020) BioRxiv, 9, pp. 382-385","McLellan, J.S.; Department of Molecular Biosciences, University of Texas at AustinUnited States; email: jmclellan@austin.utexas.edu",,American Association for the Advancement of Science,368075,,SCIEA,32075877,English,Sci.,Article,Final,,Scopus,2-s2.0-85081889457,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Leopardi S., Terregino C., Paola D.B.",55566240300;7004157305;57215781334;,Silent circulation of coronaviruses in pigs,2020,Veterinary Record,186,10,,323,,,,10.1136/vr.m932,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081904267&doi=10.1136%2fvr.m932&partnerID=40&md5=311ced1635fa74e9b967e1eb06dedfc8,"OIE Collaborating Centre for Diseases at the Animal/Human Interface, Istituto Zooprofilattico Sperimentale Delle Venezie, viale dell'Universitá 10, Padova, Italy","Leopardi, S., OIE Collaborating Centre for Diseases at the Animal/Human Interface, Istituto Zooprofilattico Sperimentale Delle Venezie, viale dell'Universitá 10, Padova, Italy; Terregino, C., OIE Collaborating Centre for Diseases at the Animal/Human Interface, Istituto Zooprofilattico Sperimentale Delle Venezie, viale dell'Universitá 10, Padova, Italy; Paola, D.B., OIE Collaborating Centre for Diseases at the Animal/Human Interface, Istituto Zooprofilattico Sperimentale Delle Venezie, viale dell'Universitá 10, Padova, Italy",[No abstract available],,angiotensin receptor; Coronavirinae; disease severity; encephalitis virus; infection risk; Italy; Letter; morbidity; mortality; nonhuman; pig; pig farming; Porcine epidemic diarrhea virus; severe acute respiratory syndrome coronavirus 2; virus replication; virus strain; virus transmission; winter,"De Souza Luna, L.K., Heiser, V., Regamey, N., Generic detection of coronaviruses and differentiation at the prototype strain level by reverse transcription-PCR and nonfluorescent low-density microarray (2007) J Clin Microbiol, 45, pp. 1049-1052; Boniotti, M.B., Papetti, A., Bertasio, C., Porcine epidemic diarrhoea virus in Italy: Disease spread and the role of transportation (2018) Transbound Emerg Dis, 65, pp. 1935-1942; Mora-Díaz, J.C., Piñeyro, P.E., Houston, E., Porcine hemagglutinating encephalomyelitis virus: A review (2019) Front Vet Sci; Wang, Q., Vlasova, A.N., Kenney, S.P., Saif, L.J., Emerging and re-emerging coronaviruses in pigs (2019) Curr Opin Virol, 34, pp. 39-49; Sungsuwan, S., Jongkaewwattana, A., Jaru-Ampornpan, P., Nucleocapsid proteins from other swine enteric coronaviruses differentially modulate PEDV replication Virology, 2020 (540), pp. 45-56; Su, S., Wong, G., Shi, W., Epidemiology, genetic recombination and pathogenesis of coronaviruses (2016) Trends Microbiol, 24, pp. 490-502; Boniotti, M.B., Papetti, A., Lavazza, A., Porcine epidemic diarrhea virus and discovery of a recombinant swine enteric coronavirus Italy (2016) Emerg Infect Dis, 22, pp. 83-87; Wan, Y., Shang, J., Graham, R., Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS (2020) J Virol; Zhou, P., Yang, X.L., Wang, X.G., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature; Zhou, P., Fan, H., Lan, T., Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin (2018) Nature, 556, pp. 255-258",,,British Veterinary Association,424900,,VETRA,32165523,English,Vet. Rec.,Letter,Final,,Scopus,2-s2.0-85081904267,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Brooks S.K., Webster R.K., Smith L.E., Woodland L., Wessely S., Greenberg N., Rubin G.J.",49460937800;57192089874;56988181100;35306052300;7102849907;7103345892;7201409301;,The psychological impact of quarantine and how to reduce it: rapid review of the evidence,2020,The Lancet,395,10227,,912,920,,4,10.1016/S0140-6736(20)30460-8,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081211304&doi=10.1016%2fS0140-6736%2820%2930460-8&partnerID=40&md5=608ea1d775cab8862122175e38ab83e4,"Department of Psychological Medicine, King's College London, London, United Kingdom","Brooks, S.K., Department of Psychological Medicine, King's College London, London, United Kingdom; Webster, R.K., Department of Psychological Medicine, King's College London, London, United Kingdom; Smith, L.E., Department of Psychological Medicine, King's College London, London, United Kingdom; Woodland, L., Department of Psychological Medicine, King's College London, London, United Kingdom; Wessely, S., Department of Psychological Medicine, King's College London, London, United Kingdom; Greenberg, N., Department of Psychological Medicine, King's College London, London, United Kingdom; Rubin, G.J., Department of Psychological Medicine, King's College London, London, United Kingdom","The December, 2019 coronavirus disease outbreak has seen many countries ask people who have potentially come into contact with the infection to isolate themselves at home or in a dedicated quarantine facility. Decisions on how to apply quarantine should be based on the best available evidence. We did a Review of the psychological impact of quarantine using three electronic databases. Of 3166 papers found, 24 are included in this Review. Most reviewed studies reported negative psychological effects including post-traumatic stress symptoms, confusion, and anger. Stressors included longer quarantine duration, infection fears, frustration, boredom, inadequate supplies, inadequate information, financial loss, and stigma. Some researchers have suggested long-lasting effects. In situations where quarantine is deemed necessary, officials should quarantine individuals for no longer than required, provide clear rationale for quarantine and information about protocols, and ensure sufficient supplies are provided. Appeals to altruism by reminding the public about the benefits of quarantine to wider society can be favourable. © 2020 Elsevier Ltd",,"altruism; attitude to illness; data base; Ebola hemorrhagic fever; economic aspect; epidemic; fear; health care cost; health care personnel management; human; infection; influenza A (H1N1); interpersonal communication; priority journal; psychological aspect; public health; quarantine; Review; severe acute respiratory syndrome; stigma; stress; symptom; Coronavirus infection; economics; financial management; mental stress; posttraumatic stress disorder; psychology; social status; social stigma; virus pneumonia; Coronavirus Infections; Financing, Personal; Humans; Pneumonia, Viral; Public Health; Quarantine; Social Conditions; Social Stigma; Stress Disorders, Post-Traumatic; Stress, Psychological","Quarantine and isolation (2017), https://www.cdc.gov/quarantine/index.html, (accessed Jan 30, 2020); Manuell, M.-E., Cukor, J., Mother Nature versus human nature: public compliance with evacuation and quarantine (2011) Disasters, 35, pp. 417-442; Newman, K., Shutt up: bubonic plague and quarantine in early modern England (2012) J Sol Hist, 45, pp. 809-834; Novel coronavirus (2019-nCoV) – what you need to know (2020), https://publichealthmatters.blog.gov.uk/2020/01/23/wuhan-novel-coronavirus-what-you-need-to-know/, (accessed Jan 31, 2020); Barbisch, D., Koenig, K.L., Shih, F.Y., Is there a case for quarantine? Perspectives from SARS to Ebola (2015) Disaster Med Public Health Prep, 9, pp. 547-553; Miles, S.H., Kaci Hickox: public health and the politics of fear (2014), http://www.bioethics.net/2014/11/kaci-hickox-public-health-and-the-politics-of-fear/, (accessed Jan 31, 2020); Rubin, G.J., Wessely, S., The psychological effects of quarantining a city (2020) BMJ, 368, p. m313; Rapid reviews to strengthen health policy and systems: a practical guide (2017), https://www.who.int/alliance-hpsr/resources/publications/rapid-review-guide/en/, (accessed Jan 31, 2020); Bai, Y., Lin, C.-C., Lin, C.-Y., Chen, J.-Y., Chue, C.-M., Chou, P., Survey of stress reactions among health care workers involved with the SARS outbreak (2004) Psychiatr Serv, 55, pp. 1055-1057; Blendon, R.J., Benson, J.M., DesRoches, C.M., Raleigh, E., Taylor-Clark, K., The public's response to severe acute respiratory syndrome in Toronto and the United States (2004) Clin Infect Dis, 38, pp. 925-931; Braunack-Mayer, A., Tooher, R., Collins, J.E., Street, J.M., Marshall, H., Understanding the school community's response to school closures during the H1N1 2009 influenza pandemic (2013) BMC Public Health, 13, p. 344; Caleo, G., Duncombe, J., Jephcott, F., The factors affecting household transmission dynamics and community compliance with Ebola control measures: a mixed-methods study in a rural village in Sierra Leone (2018) BMC Public Health, 18, p. 248; Cava, M.A., Fay, K.E., Beanlands, H.J., McCay, E.A., Wignall, R., The experience of quarantine for individuals affected by SARS in Toronto (2005) Public Health Nurs, 22, pp. 398-406; Desclaux, A., Badji, D., Ndione, A.G., Sow, K., Accepted monitoring or endured quarantine? Ebola contacts' perceptions in Senegal (2017) Soc Sci Med, 178, pp. 38-45; DiGiovanni, C., Conley, J., Chiu, D., Zaborski, J., Factors influencing compliance with quarantine in Toronto during the 2003 SARS outbreak (2004) Biosecur Bioterror, 2, pp. 265-272; Hawryluck, L., Gold, W.L., Robinson, S., Pogorski, S., Galea, S., Styra, R., SARS control and psychological effects of quarantine, Toronto, Canada (2004) Emerg Infect Dis, 10, pp. 1206-1212; Jeong, H., Yim, H.W., Song, Y.-J., Mental health status of people isolated due to Middle East respiratory syndrome (2016) Epidemiol Health, 38, p. e2016048; Lee, S., Chan, L.Y., Chau, A.M., Kwok, K.P., Kleinman, A., The experience of SARS-related stigma at Amoy Gardens (2005) Soc Sci Med, 61, pp. 2038-2046; Liu, X., Kakade, M., Fuller, C.J., Depression after exposure to stressful events: lessons learned from the severe acute respiratory syndrome epidemic (2012) Compr Psychiatry, 53, pp. 15-23; Marjanovic, Z., Greenglass, E.R., Coffey, S., The relevance of psychosocial variables and working conditions in predicting nurses' coping strategies during the SARS crisis: an online questionnaire survey (2007) Int J Nurs Stud, 44, pp. 991-998; Maunder, R., Hunter, J., Vincent, L., The immediate psychological and occupational impact of the 2003 SARS outbreak in a teaching hospital (2003) CMAJ, 168, pp. 1245-1251; Mihashi, M., Otsubo, Y., Yinjuan, X., Nagatomi, K., Hoshiko, M., Ishitake, T., Predictive factors of psychological disorder development during recovery following SARS outbreak (2009) Health Psychol, 28, pp. 91-100; Pan, P.J.D., Chang, S.-H., Yu, Y.-Y., A support group for home-quarantined college students exposed to SARS: learning from practice (2005) J Spec Group Work, 30, pp. 363-374; Pellecchia, U., Crestani, R., Decroo, T., Van den Bergh, R., Al-Kourdi, Y., Social consequences of Ebola containment measures in Liberia (2015) PLoS One, 10, p. e0143036; Reynolds, D.L., Garay, J.R., Deamond, S.L., Moran, M.K., Gold, W., Styra, R., Understanding, compliance and psychological impact of the SARS quarantine experience (2008) Epidemiol Infect, 136, pp. 997-1007; Robertson, E., Hershenfield, K., Grace, S.L., Stewart, D.E., The psychosocial effects of being quarantined following exposure to SARS: a qualitative study of Toronto health care workers (2004) Can J Psychiatry, 49, pp. 403-407; Sprang, G., Silman, M., Posttraumatic stress disorder in parents and youth after health-related disasters (2013) Disaster Med Public Health Prep, 7, pp. 105-110; Taylor, M.R., Agho, K.E., Stevens, G.J., Raphael, B., Factors influencing psychological distress during a disease epidemic: data from Australia's first outbreak of equine influenza (2008) BMC Public Health, 8, p. 347; Wang, Y., Xu, B., Zhao, G., Cao, R., He, X., Fu, S., Is quarantine related to immediate negative psychological consequences during the 2009 H1N1 epidemic? (2011) Gen Hosp Psychiatry, 33, pp. 75-77; Wester, M., Giesecke, J., Ebola and healthcare worker stigma (2019) Scand J Public Health, 47, pp. 99-104; Wilken, J.A., Pordell, P., Goode, B., Knowledge, attitudes, and practices among members of households actively monitored or quarantined to prevent transmission of Ebola virus disease–Margibi County, Liberia: February–March 2015 (2017) Prehosp Disaster Med, 32, pp. 673-678; Wu, P., Liu, X., Fang, Y., Alcohol abuse/dependence symptoms among hospital employees exposed to a SARS outbreak (2008) Alcohol Alcohol, 43, pp. 706-712; Wu, P., Fang, Y., Guan, Z., The psychological impact of the SARS epidemic on hospital employees in China: exposure, risk perception, and altruistic acceptance of risk (2009) Can J Psychiatry, 54, pp. 302-311; Yoon, M.K., Kim, S.Y., Ko, H.S., Lee, M.S., System effectiveness of detection, brief intervention and refer to treatment for the people with post-traumatic emotional distress by MERS: a case report of community-based proactive intervention in South Korea (2016) Int J Ment Health Syst, 10, p. 51; Weiss, D.S., Marmar, C.R., The impact of event scale – revised (1997) Assessing psychological trauma and PTSD, pp. 399-411. , JP Wilson TM Keane Guildford Press New York; Person, B., Sy, F., Holton, K., Fear and stigma: the epidemic within the SARS outbreak (2004) Emerg Infect Dis, 10, pp. 358-363; Alvarez, J., Hunt, M., Risk and resilience in canine search and rescue handlers after 9/11 (2005) J Trauma Stress, 18, pp. 497-505; Cukor, J., Wyka, K., Jayasinghe, N., Prevalence and predictors of posttraumatic stress symptoms in utility workers deployed to the World Trade Center following the attacks of September 11, 2001 (2011) Depress Anxiety, 28, pp. 210-217; Brooks, S.K., Dunn, R., Amlôt, R., Rubin, G.J., Greenberg, N., A systematic, thematic review of social and occupational factors associated with psychological outcomes in healthcare employees during an infectious disease outbreak (2018) J Occup Environ Med, 60, pp. 248-257; Rona, R.J., Fear, N.T., Hull, L., Mental health consequences of overstretch in the UK armed forces: first phase of a cohort study (2007) BMJ, 335, p. 603; Rubin, G.J., Harper, S., Williams, P.D., How to support staff deploying on overseas humanitarian work: a qualitative analysis of responder views about the 2014/15 West African Ebola outbreak (2016) Eur J Psychotraumatol, 7, p. 30933; Rubin, G.J., Brewin, C.R., Greenberg, N., Simpson, J., Wessely, S., Psychological and behavioural reactions to the bombings in London on 7 July 2005: cross sectional survey of a representative sample of Londoners (2005) BMJ, 331, p. 606; (2013) Diagnostic and statistical manual of mental disorders: DSM-5, , American Psychiatric Association Arlington, VA; Hull, H.F., SARS control and psychological effects of quarantine, Toronto, Canada (2005) Emerging Infectious Diseases, 11, pp. 354-355","Brooks, S.K.; Department of Psychological Medicine, King's College LondonUnited Kingdom; email: samantha.k.brooks@kcl.ac.uk",,Lancet Publishing Group,1406736,,LANCA,32112714,English,Lancet,Review,Final,Open Access,Scopus,2-s2.0-85081211304,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Gilbert M., Pullano G., Pinotti F., Valdano E., Poletto C., Boëlle P.-Y., D'Ortenzio E., Yazdanpanah Y., Eholie S.P., Altmann M., Gutierrez B., Kraemer M.U.G., Colizza V.",7202762478;57211513682;57209288568;56582534900;56586291300;7003593801;24467247600;7004429065;6603908243;57215093898;55974827300;56308225600;8225873300;,Preparedness and vulnerability of African countries against importations of COVID-19: a modelling study,2020,The Lancet,395,10227,,871,877,,7,10.1016/S0140-6736(20)30411-6,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079867190&doi=10.1016%2fS0140-6736%2820%2930411-6&partnerID=40&md5=c23d0ba7d4a4f61594891852562461ac,"Spatial Epidemiology Laboratory, Université Libre de Bruxelles, Brussels, Belgium; Fonds National de la Recherche Scientifiques, Brussels, Belgium; INSERM, Sorbonne Université, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France; Sociology and Economics of Networks and Services Laboratory at Orange Experience Design Laboratory Chatillion, Paris, France; Center for Biomedical Modeling, The Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los AngelesLA, United States; Infection, Antimicrobials, Modelling, Evolution, INSERM, Université de Paris, Paris, France; Bichat Claude Bernard Hospital, Assistance publique–Hôpitaux de Paris, Paris, France; Service des Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire de Treichville, Abidjan, Cote d'Ivoire; Département de Dermatologie-Infectiologie, Unité de Formation et de Recherche des Sciences Médicales, Université Félix Houphouet-Boigny, Abidjan, Cote d'Ivoire; IDLIC–Maladies Infectieuses Dans Les Pays à Ressources Limitées, INSERM U1219, Bordeaux, France; Bordeaux Population Health, University of Bordeaux, Bordeaux, France; Department of Zoology, University of Oxford, Oxford, United Kingdom; Harvard Medical School, Harvard University, Boston, MA, United States; Computational Epidemiology Group, Boston Children's Hospital, Boston, MA, United States","Gilbert, M., Spatial Epidemiology Laboratory, Université Libre de Bruxelles, Brussels, Belgium, Fonds National de la Recherche Scientifiques, Brussels, Belgium; Pullano, G., INSERM, Sorbonne Université, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France, Sociology and Economics of Networks and Services Laboratory at Orange Experience Design Laboratory Chatillion, Paris, France; Pinotti, F., INSERM, Sorbonne Université, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France; Valdano, E., Center for Biomedical Modeling, The Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los AngelesLA, United States; Poletto, C., INSERM, Sorbonne Université, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France; Boëlle, P.-Y., INSERM, Sorbonne Université, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France; D'Ortenzio, E., Infection, Antimicrobials, Modelling, Evolution, INSERM, Université de Paris, Paris, France, Bichat Claude Bernard Hospital, Assistance publique–Hôpitaux de Paris, Paris, France; Yazdanpanah, Y., Infection, Antimicrobials, Modelling, Evolution, INSERM, Université de Paris, Paris, France, Bichat Claude Bernard Hospital, Assistance publique–Hôpitaux de Paris, Paris, France; Eholie, S.P., Service des Maladies Infectieuses et Tropicales, Centre Hospitalier Universitaire de Treichville, Abidjan, Cote d'Ivoire, Département de Dermatologie-Infectiologie, Unité de Formation et de Recherche des Sciences Médicales, Université Félix Houphouet-Boigny, Abidjan, Cote d'Ivoire; Altmann, M., IDLIC–Maladies Infectieuses Dans Les Pays à Ressources Limitées, INSERM U1219, Bordeaux, France, Bordeaux Population Health, University of Bordeaux, Bordeaux, France; Gutierrez, B., Department of Zoology, University of Oxford, Oxford, United Kingdom; Kraemer, M.U.G., Department of Zoology, University of Oxford, Oxford, United Kingdom, Harvard Medical School, Harvard University, Boston, MA, United States, Computational Epidemiology Group, Boston Children's Hospital, Boston, MA, United States; Colizza, V., INSERM, Sorbonne Université, Institut Pierre Louis d'Epidémiologie et de Santé Publique, Paris, France","Background: The novel coronavirus disease 2019 (COVID-19) epidemic has spread from China to 25 countries. Local cycles of transmission have already occurred in 12 countries after case importation. In Africa, Egypt has so far confirmed one case. The management and control of COVID-19 importations heavily rely on a country's health capacity. Here we evaluate the preparedness and vulnerability of African countries against their risk of importation of COVID-19. Methods: We used data on the volume of air travel departing from airports in the infected provinces in China and directed to Africa to estimate the risk of importation per country. We determined the country's capacity to detect and respond to cases with two indicators: preparedness, using the WHO International Health Regulations Monitoring and Evaluation Framework; and vulnerability, using the Infectious Disease Vulnerability Index. Countries were clustered according to the Chinese regions contributing most to their risk. Findings: Countries with the highest importation risk (ie, Egypt, Algeria, and South Africa) have moderate to high capacity to respond to outbreaks. Countries at moderate risk (ie, Nigeria, Ethiopia, Sudan, Angola, Tanzania, Ghana, and Kenya) have variable capacity and high vulnerability. We identified three clusters of countries that share the same exposure to the risk originating from the provinces of Guangdong, Fujian, and the city of Beijing, respectively. Interpretation: Many countries in Africa are stepping up their preparedness to detect and cope with COVID-19 importations. Resources, intensified surveillance, and capacity building should be urgently prioritised in countries with moderate risk that might be ill-prepared to detect imported cases and to limit onward transmission. Funding: EU Framework Programme for Research and Innovation Horizon 2020, Agence Nationale de la Recherche. © 2020 Elsevier Ltd",,"2019 novel coronavirus; Africa; airport; alertness; Algeria; Angola; Article; aviation; China; controlled study; Coronavirinae; Egypt; emergency; epidemic; Ethiopia; Ghana; human; Infectious Disease Vulnerability Index; international health regulation; Kenya; medicolegal aspect; Monitoring and Evaluation Framework; Nigeria; nonhuman; priority journal; risk assessment; scoring system; South Africa; Sudan; Tanzania; World Health Organization; civil defense; Coronavirus infection; epidemic; health care planning; health survey; theoretical model; travel; virus pneumonia; vulnerable population; Africa; China; Civil Defense; Coronavirus Infections; Epidemics; Health Planning; Health Resources; Humans; Models, Theoretical; Pneumonia, Viral; Population Surveillance; Risk Assessment; Travel; Vulnerable Populations","Statement on the second meeting of the International Health Regulations (2005) Emergency Committee regarding the outbreak of novel coronavirus (COVID-19) (2020), https://www.who.int/news-room/detail/30-01-2020-statement-on-the-second-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-outbreak-of-novel-coronavirus-(COVID-19), WHO Geneva (Accessed 1 February 2020); Novel coronavirus (COVID-19) situation report–22 (2020), https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200211-sitrep-22-ncov.pdf?sfvrsn=fb6d49b1_2, (Accessed 11 February 2020); Coronavirus: l'Afrique en état d'alerte (2020), https://www.lemonde.fr/afrique/article/2020/01/28/coronavirus-l-afrique-sur-ses-gardes_6027538_3212.html, (Accessed 1 February 2020); WHO ramps up preparedness for novel coronavirus in the African region (2020), https://www.afro.who.int/news/who-ramps-preparedness-novel-coronavirus-african-region, (Accessed 1 February 2020); Pullano, G., Pinotti, F., Valdano, E., Boëlle, P.-Y., Poletto, C., Colizza, V., Novel coronavirus (COVID-19) early-stage importation risk to Europe (2020) Eurosurveillance, 25; Bogoch, I.I., Watts, A., Thomas-Bachli, A., Huber, C., Kraemer, M.U.G., Khan, K., Pneumonia of unknown etiology in Wuhan, China: potential for international spread via commercial air travel (2020) J Travel Med, , published online Jan 14; Wu, J.T., Leung, K., Leung, G.M., Nowcasting and forecasting the potential domestic and international spread of the COVID-19 outbreak originating in Wuhan, China: a modelling study (2020) Lancet, , published online Jan 31; Chinazzi, M., Davis, J.T., Ajelli, M., The effect of travel restrictions on the spread of the 2019 novel coronavirus (COVID-19) outbreak (2020) medRxiv, , published online Feb 11 (preprint); Lai, S., Bogoch, I.I., Watts, A., Khan, K., Li, Z., Tatem, A., Preliminary risk analysis of 2019 novel coronavirus spread within and beyond China https://www.worldpop.org/resources/docs/china/WorldPop-coronavirus-spread-risk-analysis-v1-25Jan.pdf, (Accessed 1 February 2020); International health regulations (2005): State Party Self-Assessment Annual Reporting Tool (2018), https://apps.who.int/iris/handle/10665/272432, World Health Organization Geneva (Accessed 28 January 2020); http://epirisk.net/, (Accessed 28 January 2020); 2018 Civil Aviation Airport Production Statistics Bulletin (2019), http://www.caac.gov.cn/XXGK/XXGK/TJSJ/201903/P020190305338562571372.xls?COLLCC=3782305670&, (in Chinese). (Accessed 28 January 2020); Coronavirus COVID-19 global cases https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6, (Accessed 11 February 2020); China: provinces and major cities (2020), http://www.citypopulation.de/en/china/cities/, (Accessed 28 January 2020); Manning, C.D., Schütze, H., Foundations of statistical natural language processing (1999), MIT Press Cambridge, MA; Joint external evaluation tool: International Health Regulations (2005) (2018), https://apps.who.int/iris/handle/10665/259961, 2nd edn. World Health Organization Geneva (Accessed 11 February 2020); Electronic State Parties Self-Assessment Annual Reporting Tool https://extranet.who.int/e-spar, (Accessed 28 January 2020); Moore, M., Gelfeld, B., Okunogbe, A., Paul, C., Gelfeld, B., Identifying future disease hot spots: infectious disease vulnerability index (2016), https://www.rand.org/pubs/research_reports/RR1605.html, (Accessed 28 January 2020); Poljanšek, K., Marin-Ferrer, M., Vernaccini, L., Messina, L., Incorporating epidemics risk in the INFORM Global Risk Index. EUR 29603 EN (2018), http://publications.jrc.ec.europa.eu/repository/handle/JRC114652, Publications Office of the European Union Luxembourg (Accessed 11 February 2020); M'Bida, A., Un Boeing de la Royal Air Maroc. Royal Air Maroc, RwandAir, Kenya Airways, six des huit compagnies aériennes africaines qui desservent la Chine, en proie à une épidémie de coronavirus, ont décidé de suspendre leurs liaisons. Ethiopian Airlines et Air Algérie ont choisi de maintenir leurs vols (2020) Jeune Afrique, , https://www.jeuneafrique.com/889706/economie/coronavirus-lafrique-met-la-chine-en-quarantaine/, (Accessed 1 February 2020); Zhou, Y., Quartz Africa https://qz.com/africa/1675287/china-toafrica-fights-jumped-630-in-the-past-nine-years/, (Accessed 1 February 2020); Poletto, C., Gomes, M.F.C., Pastore y Piontti, A., Assessing the impact of travel restrictions on international spread of the 2014 West African Ebola epidemic (2014) Eurosurveillance, 19, p. 42; Bajardi, P., Poletto, C., Ramasco, J.J., Tizzoni, M., Colizza, V., Vespignani, A., Human mobility networks, travel restrictions, and the global spread of 2009 H1N1 pandemic (2011) PLoS One, 6; Nkengasong, J., China's response to a novel coronavirus stands in stark contrast to the 2002 SARS outbreak response (2020) Nat Med, , published online Jan 27; Steenhuysen, J., Nebehay, S., Countries rush to build diagnostic capacity as coronavirus spreads (2020) Reuters, , https://www.reuters.com/article/us-china-health-diagnostics-focus/countries-rush-to-build-diagnostic-capacity-as-coronavirus-spreads-idUSKBN2042DV, (Accessed 11 February 2020); Sambala, E.Z., Kanyenda, T., Iwu, C.J., Pandemic influenza preparedness in the WHO African region: are we ready yet? (2018) BMC Infect Dis, 18, p. 567; Sands, P., Mundaca-Shah, C., Dzau, V.J., The neglected dimension of global security—a framework for countering infectious-disease crises (2016) N Engl J Med, 374, pp. 1281-1287; Marston, B.J., Dokubo, E., van Steelandt, A., Ebola response impact on public health programs, west Africa, 2014–2017 (2017) Emerg Infect Dis, 23","Colizza, V.; INSERM, Sorbonne Université, Institut Pierre Louis d'Epidémiologie et de Santé Publique, IPLESPFrance; email: vittoria.colizza@inserm.fr",,Lancet Publishing Group,1406736,,LANCA,32087820,English,Lancet,Article,Final,Open Access,Scopus,2-s2.0-85079867190,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Graham J.B., Swarts J.L., Menachery V.D., Gralinski L.E., Schäfer A., Plante K.S., Morrison C.R., Voss K.M., Green R., Choonoo G., Jeng S., Miller D.R., Mooney M.A., McWeeney S.K., Ferris M.T., De Villena F.P.-M., Gale M., Heise M.T., Baric R.S., Lund J.M.",36874227300;56719316200;24281639500;6505609367;8599352200;34873397100;56095498400;57192236890;55614352900;57041201200;8425019300;12243071300;35071623900;6603500126;16642383800;57215486757;55382766000;7007179211;57205312930;24401137500;,Immune Predictors of Mortality after Ribonucleic Acid Virus Infection,2020,Journal of Infectious Diseases,221,6,,882,889,,,10.1093/infdis/jiz531,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081138274&doi=10.1093%2finfdis%2fjiz531&partnerID=40&md5=a24d639de316d40f2f00b8ebdaf00eee,"Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Department of Microbiology and Immunology, University of Texas Medical Center, Galveston, TX, United States; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA, United States; Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology, Oregon Health and Science University, Portland, OR, United States; OHSU Knight Cancer Institute, Oregon Health and Science University, Portland, OR, United States; Oregon Clinical and Translational Research Institute, Oregon Health and Science University, Portland, OR, United States; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Department of Global Health, University of Washington, Seattle, WA, United States","Graham, J.B., Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States; Swarts, J.L., Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States; Menachery, V.D., Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, Department of Microbiology and Immunology, University of Texas Medical Center, Galveston, TX, United States; Gralinski, L.E., Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Schäfer, A., Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Plante, K.S., Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Morrison, C.R., Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Voss, K.M., Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA, United States; Green, R., Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA, United States; Choonoo, G., Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology, Oregon Health and Science University, Portland, OR, United States; Jeng, S., Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology, Oregon Health and Science University, Portland, OR, United States; Miller, D.R., Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Mooney, M.A., Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology, Oregon Health and Science University, Portland, OR, United States, OHSU Knight Cancer Institute, Oregon Health and Science University, Portland, OR, United States; McWeeney, S.K., Division of Bioinformatics and Computational Biology, Department of Medical Informatics and Clinical Epidemiology, Oregon Health and Science University, Portland, OR, United States, OHSU Knight Cancer Institute, Oregon Health and Science University, Portland, OR, United States, Oregon Clinical and Translational Research Institute, Oregon Health and Science University, Portland, OR, United States; Ferris, M.T., Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; De Villena, F.P.-M., Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Gale, M., Center for Innate Immunity and Immune Disease, Department of Immunology, University of Washington School of Medicine, Seattle, WA, United States; Heise, M.T., Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Baric, R.S., Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Lund, J.M., Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States, Department of Global Health, University of Washington, Seattle, WA, United States","Background: Virus infections result in a range of clinical outcomes for the host, from asymptomatic to severe or even lethal disease. Despite global efforts to prevent and treat virus infections to limit morbidity and mortality, the continued emergence and re-emergence of new outbreaks as well as common infections such as influenza persist as a health threat. Challenges to the prevention of severe disease after virus infection include both a paucity of protective vaccines as well as the early identification of individuals with the highest risk that may require supportive treatment. Methods: We completed a screen of mice from the Collaborative Cross (CC) that we infected with influenza, severe acute respiratory syndrome-coronavirus, and West Nile virus. Results: The CC mice exhibited a range of disease manifestations upon infections, and we used this natural variation to identify strains with mortality after infection and strains exhibiting no mortality. We then used comprehensive preinfection immunophenotyping to identify global baseline immune correlates of protection from mortality to virus infection. Conclusions: These data suggest that immune phenotypes might be leveraged to identify humans at highest risk of adverse clinical outcomes upon infection, who may most benefit from intensive clinical interventions, in addition to providing insight for rational vaccine design. © 2019 The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. 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Infect. Dis.,Article,Final,,Scopus,2-s2.0-85081138274,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Korean Society of Infectious Diseases,,"Report on the epidemiological features of coronavirus disease 2019 (covid-19) outbreak in the republic of korea from january 19 to march 2, 2020",2020,Journal of Korean Medical Science,35,10, e112,,,,1,10.3346/jkms.2020.35.e112,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081994981&doi=10.3346%2fjkms.2020.35.e112&partnerID=40&md5=fc501fe05ecd697524d46081b6370dca,"23 Seocho-daero 74-gil, Seocho-gu, Seoul, 06621, South Korea",Korean Society of Infectious Diseases,"Since the first case of coronavirus disease19 (COVID-19) was reported in Wuhan, China, as of March 2, 2020, the total number of confirmed cases of COVID-19 was 89,069 cases in 67 countries and regions. As of 0 AM, March 2, 2020, the Republic of Korea had the second-largest number of confirmed cases (n = 4,212) after China (n = 80,026). This report summarizes the epidemiologic features and the snapshots of the outbreak in the Republic of Korea from January 19 and March 2, 2020. © 2020 The Korean Academy of Medical Sciences.",Coronavirus; COVID-19; Epidemiology; Korea; SARS-cov-2,"COVID-19; severe acute respiratory syndrome coronavirus 2; adolescent; adult; age distribution; aged; Betacoronavirus; child; Coronavirus infection; epidemic; female; human; infant; isolation and purification; male; middle aged; pathogenicity; preschool child; sex ratio; South Korea; very elderly; virus pneumonia; young adult; Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Betacoronavirus; Child; Child, Preschool; Coronavirus Infections; Disease Outbreaks; Female; Humans; Infant; Male; Middle Aged; Pneumonia, Viral; Republic of Korea; Sex Distribution; Young Adult","Kim, J.Y., Choe, P.G., Oh, Y., Oh, K.J., Kim, J., Park, S.J., The first case of 2019 novel coronavirus pneumonia imported into Korea from Wuhan, China: implication for infection prevention and control measures (2020) J Korean Med Sci, 35 (5), p. e61; Yoo, J.H., The fight against the 2019-nCoV outbreak: an arduous march has just begun (2020) J Korean Med Sci, 35 (4), p. e56; The update of COVID-19 in Korea as of 19 February (2020), http://ncov.mohw.go.kr/tcmBoardView.do?brdId=&brdGubun=&dataGubun=&ncvContSeq=352991&contSeq=352991&board_id=&gubun=ALL, Updated 2020. Accessed March 2; (2020), http://overseas.mofa.go.kr/viewer/skin/doc.html?fn=2020022902071300&rs=/viewer/result/202003, Updated 2020. Accessed March 2; (2020), http://www.mohw.go.kr/react/al/sal0301vw.jsp?PAR_MENU_ID=04&MENU_ID=0403&page=1&CONT_SEQ=352572&SEARCHKEY=TITLE&SEARCH, The update of COVID-19 in Korea as of 30 January. Updated 2020. Accessed March 2; (2020), http://ncov.mohw.go.kr/tcmBoardView.do?brdId=&brdGubun=&dataGubun=&ncvContSeq=352735&contSeq=352735&board_id=140&gubun=BDJ, Press release reported February 2. Updated 2020. Accessed March 2, 2020; The update of COVID-19 in Korea as of February 23 (2020), https://www.cdc.go.kr/board/board.es?mid=a20501000000&bid=0015&list_no=366304&act=view, Updated 2020. Accessed March 2; The update of COVID-19 in Korea as of March 2. (2020), http://ncov.mohw.go.kr/tcmBoardView.do?brdId=&brdGubun=&dataGubun=&ncvContSeq=353272&contSeq=353277, Updated 2020. Accessed March 2; Press release about trends by city and province updated March 1 (2020), http://ncov.mohw.go.kr/bdBoardList_Real.do?brdId=1&brdGubun=13&ncvContSeq=&contSeq=&board_id=&gubun=, Updated 2020. Accessed March 2, 2020; The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China (2020) Zhonghua Liu Xing Bing Xue Za Zhi, 41 (2), pp. 145-151; Wu, Z., McGoogan, J.M., Characteristics of and important lessons from the Coronavirus Disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention (2020) JAMA Forthcoming; 2018 population census updated by the KOSIS (2019), http://kosis.kr/statisticsList/statisticsListIndex.do?menuId=M_01_01&vwcd=MT_ZTITLE&parmTabId=M_01_01#SelectStatsBoxDiv, August 29. Updated 2020. Accessed March 2, 2020; The updates of COVID-19 in Gyeongnam updated March 2 (2020), http://www.gyeongnam.go.kr/corona.html, Updated 2020. Accessed March 2, 2020; (2020), http://www.daegu.go.kr/health/index.do?menu_id=00936550&menu_link=/icms/bbs/selectoardArticle.do&bbsId=BBS_02098, Press release of COVID-19 in Daegu as of February 29. Updated 2020. Accessed March 2, 2020; Press release of COVID-19 in Daegu as of March 2 (2020), http://www.daegu.go.kr/health/index.do?menu_id=00936550&menu_link=/icms/bbs/selectBoardArticle.do&bbsId=BBS_02098, Updated 2020. Accessed March 2, 2020",,,Korean Academy of Medical Science,10118934,,JKMSE,32174069,English,J. Korean Med. Sci.,Article,Final,Open Access,Scopus,2-s2.0-85081994981,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Yuen K.-S., Ye Z.-W., Fung S.-Y., Chan C.-P., Jin D.-Y.",55588721400;56611152500;56956400000;36193690700;7201973614;,SARS-CoV-2 and COVID-19: The most important research questions,2020,Cell and Bioscience,10,1,40,,,,,10.1186/s13578-020-00404-4,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082134682&doi=10.1186%2fs13578-020-00404-4&partnerID=40&md5=5c27204dfa02b81ee3c909866b8d98ce,"School of Biomedical Sciences, University of Hong Kong, 3/F Laboratory Block, 21 Sassoon Road, Pokfulam, Hong Kong; Department of Microbiology, University of Hong Kong, Pokfulam, Hong Kong","Yuen, K.-S., School of Biomedical Sciences, University of Hong Kong, 3/F Laboratory Block, 21 Sassoon Road, Pokfulam, Hong Kong; Ye, Z.-W., Department of Microbiology, University of Hong Kong, Pokfulam, Hong Kong; Fung, S.-Y., School of Biomedical Sciences, University of Hong Kong, 3/F Laboratory Block, 21 Sassoon Road, Pokfulam, Hong Kong; Chan, C.-P., School of Biomedical Sciences, University of Hong Kong, 3/F Laboratory Block, 21 Sassoon Road, Pokfulam, Hong Kong; Jin, D.-Y., School of Biomedical Sciences, University of Hong Kong, 3/F Laboratory Block, 21 Sassoon Road, Pokfulam, Hong Kong","Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an ongoing global health emergency. Here we highlight nine most important research questions concerning virus transmission, asymptomatic and presymptomatic virus shedding, diagnosis, treatment, vaccine development, origin of virus and viral pathogenesis. © 2020 The Author(s).",2019 novel coronavirus (2019-nCoV); COVID-19; Novel coronavirus pneumonia (NCP); SARS-CoV-2,antivirus agent; cryopyrin; immunoglobulin G antibody; immunoglobulin M antibody; inactivated vaccine; remdesivir; virus RNA; antiviral activity; Article; case fatality rate; clinical feature; coronavirus disease 2019; Coronavirus infection; cytokine storm; disease eradication; disease exacerbation; disease severity; high risk population; human; intermediate host; nonhuman; SARS coronavirus; severe acute respiratory syndrome coronavirus 2; virus pathogenesis; virus shedding; virus transmission; World Health Organization,"Chan, J.F.W., Yuan, S., Kok, K.H., To, K.K.W., Chu, H., Yang, J., Xing, F., Yuen, K.Y., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: A study of a family cluster (2020) Lancet, 395, pp. 514-523. , 1:CAS:528:DC%2BB3cXhs1Ojsro%3D; Bai, Y., Yao, L., Wei, T., Tian, F., Jin, D.Y., Chen, L., Wang, M., Presumed asymptomatic carrier transmission of COVID-19 (2020) Jama, , 10.1001/jama.2020.1585 32083643; Zhou, P., Yang, X.L., Wang, X.G., Hu, B., Zhang, L., Zhang, W., Si, H.R., Shi, Z.L., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature, , 10.1038/s41586-020-2012-7 32132689; Lam, T.T.Y., Shum, M.H.H., Zhu, H.C., Tong, Y.G., Ni, X.B., Liao, Y.S., Wei, W., Guan, Y., Identification of 2019-nCoV related coronaviruses in Malayan pangolins in southern China (2020) BioRxiv, , 10.1101/2020.02.13.945485; Lu, R., Zhao, X., Li, J., Niu, P., Yang, B., Wu, H., Wang, W., Tan, W., Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding (2020) Lancet, , 10.1016/S0140-6736(20)30251-8 32151317; Vital surveillances: The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19)-China (2020) China CDC Weekly., 2 (8), pp. 113-122. , The Novel Coronavirus Pneumonia Emergency Response Epidemiology Team; Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Wang, B., Peng, Z., Clinical characteristics of 138 hospitalized patients with 2019, novel coronavirus-infected pneumonia in Wuhan China (2020) Jama, , 10.1001/jama.2020.1585 32159775; Wu, J.T., Leung, K., Leung, G.M., Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: A modelling study (2020) Lancet, 395, pp. 689-697. , 10.1016/S0140-6736(20)30260-9 32014114; Heimdal, I., Moe, N., Krokstad, S., Christensen, A., Skanke, L.H., Nordbø, S.A., Døllner, H., Human coronavirus in hospitalized children with respiratory tract infections: A 9-year population-based study from Norway (2019) J Infect Dis, 219 (8), pp. 1198-1206; De Wit, E., Feldmann, F., Cronin, J., Jordan, R., Okumura, A., Thomas, T., Scott, D., Feldmann, H., Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection (2020) Pnas, , 10.1073/pnas.1922083117 32054787; Gao, R., Cao, B., Hu, Y., Feng, Z., Wang, D., Hu, W., Chen, J., Shu, Y., Human infection with a novel avian-origin influenza virus (2013) N Engl J Med., 368, pp. 1888-1897. , 1:CAS:528:DC%2BC3sXnsl2gsrc%3D; Yu, X.J., Liang, M.F., Zhang, S.Y., Liu, Y., Li, J.D., Sun, Y.L., Zhang, L., Li, D.X., Fever with thrombocytopenia associated with a novel bunyavirus in China (2011) N Engl J Med, 364 (16), pp. 1523-1532. , 1:CAS:528:DC%2BC3MXltlCjt7w%3D","Jin, D.-Y.; School of Biomedical Sciences, University of Hong Kong, 3/F Laboratory Block, 21 Sassoon Road, Hong Kong; email: dyjin@hku.hk",,BioMed Central Ltd.,20453701,,,,English,Cell Biosci.,Article,Final,Open Access,Scopus,2-s2.0-85082134682,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Yoo J.-H.,7402295435;,Will the third wave of coronavirus disease 2019 really come in korea,2020,Journal of Korean Medical Science,35,10, e110,,,,,10.3346/jkms.2020.35.e110,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082007846&doi=10.3346%2fjkms.2020.35.e110&partnerID=40&md5=790aa195fbf7e20e540d53a47c48ecb9,"Division of Infectious Diseases, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea; Division of Infectious Diseases, Department of Internal Medicine, Bucheon St. Mary's Hospital, Bucheon, South Korea","Yoo, J.-H., Division of Infectious Diseases, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, South Korea, Division of Infectious Diseases, Department of Internal Medicine, Bucheon St. Mary's Hospital, Bucheon, South Korea",[No abstract available],,,"Current statistics of COVID-19 in Korea http://ncov.mohw.go.kr/bdBoardList_Real.do?brdId=1&brdGubun=13&ncvContSeq=&contSeq=&board_id=&gubun=, Updated 2020. Accessed March 8, 2020; Tang, X., Wu, C., Li, X., Song, Y., Yao, X., Wu, X., On the origin and continuing evolution of SARS-CoV-2 (2020) Natl Sci Rev","Yoo, J.-H.; Division of Infectious Diseases, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, 327 Sosa-ro, Wonmi-gu, South Korea; email: jhyoo@catholic.ac.kr",,Korean Academy of Medical Science,10118934,,JKMSE,32174068,English,J. Korean Med. Sci.,Article,Final,Open Access,Scopus,2-s2.0-85082007846,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Paterlini M.,57204166786;,On the front lines of coronavirus: the Italian response to covid-19,2020,BMJ (Clinical research ed.),368,,,m1065,,,1,10.1136/bmj.m1065,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081991318&doi=10.1136%2fbmj.m1065&partnerID=40&md5=4e4868061d0b8b0e5429ab8ff13a5dee,"Stockholm, Sweden","Paterlini, M., Stockholm, Sweden",[No abstract available],,,,,,NLM (Medline),17561833,,,32179517,English,BMJ,Article,Final,Open Access,Scopus,2-s2.0-85081991318,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Vincent J.-L., Slutsky A.S.",7403122266;56861871200;,Coronavirus: Just imagine...,2020,Critical Care,24,1,90,,,,,10.1186/s13054-020-2824-8,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081988129&doi=10.1186%2fs13054-020-2824-8&partnerID=40&md5=93100fe7eb9b9f11915e3b781012bb7e,"Department of Intensive Care, Erasme University Hospital, Université Libre de Bruxelles, Route de Lennik 808, Brussels, 1070, Belgium; Keenan Research Center for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Canada; Departments of Medicine Surgery, and Biomedical Engineering, University of Toronto, Toronto, Canada","Vincent, J.-L., Department of Intensive Care, Erasme University Hospital, Université Libre de Bruxelles, Route de Lennik 808, Brussels, 1070, Belgium; Slutsky, A.S., Keenan Research Center for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Canada, Departments of Medicine Surgery, and Biomedical Engineering, University of Toronto, Toronto, Canada",[No abstract available],,"chronic respiratory failure; Coronavirus infection; COVID 19; Editorial; emergency ward; extracorporeal oxygenation; health care availability; health care facility; health care personnel; hospital admission; human; intensive care unit; multiple chronic conditions; patient care; patient transport; priority journal; quarantine; SARS coronavirus; SARS coronavirus 2; virus pneumonia; virus transmission; Betacoronavirus; Coronavirus infection; epidemic; health care personnel; hospital bed utilization; organization and management; pandemic; virus pneumonia; COVID-19; severe acute respiratory syndrome coronavirus 2; Bed Occupancy; Betacoronavirus; Coronavirus Infections; Disease Outbreaks; Health Personnel; Health Workforce; Humans; Intensive Care Units; Pandemics; Pneumonia, Viral","Lu, R., Zhao, X., Li, J., Niu, P., Yang, B., Wu, H., Wang, W., Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding (2020) Lancet, 395, pp. 565-574; Wu, J.T., Leung, K., Leung, G.M., Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: A modelling study (2020) Lancet, 395, pp. 689-697; Swerdlow, D.L., Finelli, L., Preparation for possible sustained transmission of 2019 novel coronavirus lessons from previous epidemics (2020) JAMA, , https://doi.org/10.1001/jama.2020.1960, [Epub ahead of print]","Vincent, J.-L.; Department of Intensive Care, Erasme University Hospital, Université Libre de Bruxelles, Route de Lennik 808, Belgium; email: jlvincent@intensive.org",,BioMed Central Ltd.,13648535,,CRCAF,32178716,English,Crit. Care,Editorial,Final,Open Access,Scopus,2-s2.0-85081988129,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wan Y., Shang J., Graham R., Baric R.S., Li F.",55620829000;57191992928;57203199836;57205312930;26028899600;,Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus,2020,Journal of virology,94,7,,,,,38,10.1128/JVI.00127-20,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079372059&doi=10.1128%2fJVI.00127-20&partnerID=40&md5=8fcf70d48b69e2d07a0bb4399a41da1e,"Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, Minnesota, USA; Department of Epidemiology, University of North Carolina, Chapel HillNC, United States","Wan, Y., Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, Minnesota, USA; Shang, J., Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, Minnesota, USA; Graham, R., Department of Epidemiology, University of North Carolina, Chapel HillNC, United States; Baric, R.S., Department of Epidemiology, University of North Carolina, Chapel HillNC, United States; Li, F., Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, Minnesota, USA","Recently, a novel coronavirus (2019-nCoV) has emerged from Wuhan, China, causing symptoms in humans similar to those caused by severe acute respiratory syndrome coronavirus (SARS-CoV). Since the SARS-CoV outbreak in 2002, extensive structural analyses have revealed key atomic-level interactions between the SARS-CoV spike protein receptor-binding domain (RBD) and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of SARS-CoV. Here, we analyzed the potential receptor usage by 2019-nCoV, based on the rich knowledge about SARS-CoV and the newly released sequence of 2019-nCoV. First, the sequence of 2019-nCoV RBD, including its receptor-binding motif (RBM) that directly contacts ACE2, is similar to that of SARS-CoV, strongly suggesting that 2019-nCoV uses ACE2 as its receptor. Second, several critical residues in 2019-nCoV RBM (particularly Gln493) provide favorable interactions with human ACE2, consistent with 2019-nCoV's capacity for human cell infection. Third, several other critical residues in 2019-nCoV RBM (particularly Asn501) are compatible with, but not ideal for, binding human ACE2, suggesting that 2019-nCoV has acquired some capacity for human-to-human transmission. Last, while phylogenetic analysis indicates a bat origin of 2019-nCoV, 2019-nCoV also potentially recognizes ACE2 from a diversity of animal species (except mice and rats), implicating these animal species as possible intermediate hosts or animal models for 2019-nCoV infections. These analyses provide insights into the receptor usage, cell entry, host cell infectivity and animal origin of 2019-nCoV and may help epidemic surveillance and preventive measures against 2019-nCoV.IMPORTANCE The recent emergence of Wuhan coronavirus (2019-nCoV) puts the world on alert. 2019-nCoV is reminiscent of the SARS-CoV outbreak in 2002 to 2003. Our decade-long structural studies on the receptor recognition by SARS-CoV have identified key interactions between SARS-CoV spike protein and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of SARS-CoV. One of the goals of SARS-CoV research was to build an atomic-level iterative framework of virus-receptor interactions to facilitate epidemic surveillance, predict species-specific receptor usage, and identify potential animal hosts and animal models of viruses. Based on the sequence of 2019-nCoV spike protein, we apply this predictive framework to provide novel insights into the receptor usage and likely host range of 2019-nCoV. This study provides a robust test of this reiterative framework, providing the basic, translational, and public health research communities with predictive insights that may help study and battle this novel 2019-nCoV. Copyright © 2020 American Society for Microbiology.",2019-nCoV; angiotensin-converting enzyme 2; animal reservoir; cross-species transmission; human-to-human transmission; SARS coronavirus,"angiotensin converting enzyme 2; coronavirus spike glycoprotein; COVID-19; dipeptidyl carboxypeptidase; severe acute respiratory syndrome coronavirus 2; virus receptor; amino acid sequence; animal; bat; Betacoronavirus; chemistry; China; classification; Coronavirus infection; host range; human; molecular model; phylogeny; physiology; protein domain; SARS coronavirus; sequence alignment; virology; virus pneumonia; Amino Acid Sequence; Animals; Betacoronavirus; China; Chiroptera; Coronavirus Infections; Host Specificity; Humans; Models, Molecular; Peptidyl-Dipeptidase A; Phylogeny; Pneumonia, Viral; Protein Domains; Receptors, Virus; SARS Virus; Sequence Alignment; Spike Glycoprotein, Coronavirus",,,,NLM (Medline),10985514,,,31996437,English,J. Virol.,Article,Final,Open Access,Scopus,2-s2.0-85079372059,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Adhikari S.P., Meng S., Wu Y.-J., Mao Y.-P., Ye R.-X., Wang Q.-Z., Sun C., Sylvia S., Rozelle S., Raat H., Zhou H.",57211296357;57210451217;57089163900;55960593800;57209161112;57204459121;57210441228;55341111300;7005703248;7003734797;38062649700;,"Epidemiology, causes, clinical manifestation and diagnosis, prevention and control of coronavirus disease (COVID-19) during the early outbreak period: A scoping review",2020,Infectious Diseases of Poverty,9,1,29,,,,,10.1186/s40249-020-00646-x,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082020443&doi=10.1186%2fs40249-020-00646-x&partnerID=40&md5=be6536042dfd0cfa5e465cfff6b364aa,"West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China; Department of Communication Studies, California State University, Long Beach, CA 90802, United States; Health Policy and Management, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Freeman Spogli Institute for International Studies, Stanford University, Stanford, CA, United States; Department of Public Health, Erasmus MC - University Medical Center Rotterdam, Rotterdam, CA 3000, Netherlands","Adhikari, S.P., West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China; Meng, S., West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China; Wu, Y.-J., West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China; Mao, Y.-P., Department of Communication Studies, California State University, Long Beach, CA 90802, United States; Ye, R.-X., West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China; Wang, Q.-Z., West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China; Sun, C., West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China; Sylvia, S., Health Policy and Management, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Rozelle, S., Freeman Spogli Institute for International Studies, Stanford University, Stanford, CA, United States; Raat, H., Department of Public Health, Erasmus MC - University Medical Center Rotterdam, Rotterdam, CA 3000, Netherlands; Zhou, H., West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China","Background: The coronavirus disease (COVID-19) has been identified as the cause of an outbreak of respiratory illness in Wuhan, Hubei Province, China beginning in December 2019. As of 31 January 2020, this epidemic had spread to 19 countries with 11 791 confirmed cases, including 213 deaths. The World Health Organization has declared it a Public Health Emergency of International Concern. Methods: A scoping review was conducted following the methodological framework suggested by Arksey and O'Malley. In this scoping review, 65 research articles published before 31 January 2020 were analyzed and discussed to better understand the epidemiology, causes, clinical diagnosis, prevention and control of this virus. The research domains, dates of publication, journal language, authors' affiliations, and methodological characteristics were included in the analysis. All the findings and statements in this review regarding the outbreak are based on published information as listed in the references. Results: Most of the publications were written using the English language (89.2%). The largest proportion of published articles were related to causes (38.5%) and a majority (67.7%) were published by Chinese scholars. Research articles initially focused on causes, but over time there was an increase of the articles related to prevention and control. Studies thus far have shown that the virus' origination is in connection to a seafood market in Wuhan, but specific animal associations have not been confirmed. Reported symptoms include fever, cough, fatigue, pneumonia, headache, diarrhea, hemoptysis, and dyspnea. Preventive measures such as masks, hand hygiene practices, avoidance of public contact, case detection, contact tracing, and quarantines have been discussed as ways to reduce transmission. To date, no specific antiviral treatment has proven effective; hence, infected people primarily rely on symptomatic treatment and supportive care. Conclusions: There has been a rapid surge in research in response to the outbreak of COVID-19. During this early period, published research primarily explored the epidemiology, causes, clinical manifestation and diagnosis, as well as prevention and control of the novel coronavirus. Although these studies are relevant to control the current public emergency, more high-quality research is needed to provide valid and reliable ways to manage this kind of public health emergency in both the short- and long-term. © 2020 The Author(s).",Causes; COVID-19; Epidemiology; Prevention and control; Review,"2019 novel coronavirus; coronavirus disease 2019; coughing; diarrhea; disease severity; disease surveillance; disease transmission; dyspnea; fatigue; fever; headache; health care; hemoptysis; high throughput sequencing; human; incubation time; meta analysis; mortality rate; pathogenesis; pneumonia; prevention and control; priority journal; public health; public health service; quality control; real time polymerase chain reaction; respiratory tract infection; Review; rhinorrhea; severe acute respiratory syndrome; systematic review; virology; Betacoronavirus; China; Coronavirus infection; coughing; dyspnea; epidemic; fatigue; fever; headache; infection control; virology; virus pneumonia; COVID-19; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; China; Coronavirus Infections; Cough; Disease Outbreaks; Dyspnea; Fatigue; Fever; Headache; Humans; Infection Control; Pneumonia, Viral","(2020) Wuhan Municipal Health and Health Commission's Briefing on the Current Pneumonia Epidemic Situation in Our City, , http://wjw.wuhan.gov.cn/front/web/showDetail/2019123108989, WMHC, Accessed 1 Feb 2020; Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med., , https://doi.org/10.1056/NEJMoa2001316; (2019) Novel Coronavirus, , https://www.cdc.gov/coronavirus/2019-nCoV/summary.html, CDC, Wuhan, China, Accessed 1 Feb 2020; (2020), https://www.who.int/csr/don/12-january-2020-novel-coronavirus-china/en/, WHO. Novel Coronavirus-China, Accessed 1 Feb 2020; Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, , https://doi.org/10.1056/NEJMoa2001017; (2020), https://www.who.int/csr/don/17-january-2020-novel-coronavirus-japan-ex-china/en/, WHO. Novel Coronavirus-Japan (ex-China), Accessed 1 Feb 2020; (2020), http://virological.org/t/novel-2019-coronavirus-genome/319, Virological.org. 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Accessed 3 Feb 2020; (2020) Guidelines for Public Protection against Novel Coronavirus Infection, , http://www.nhc.gov.cn/jkj/s7915/202001/bc661e49b5bc487dba182f5c49ac445b.shtml, National Health Commission of People's Republic of China, Accessed 31 Jan 2020","Zhou, H.; West China School of Public Health and West China Fourth Hospital, Sichuan UniversityChina; email: zhouhuan@scu.edu.cn",,BioMed Central Ltd.,20955162,,,32183901,English,Infect. Dis. Pover.,Review,Final,Open Access,Scopus,2-s2.0-85082020443,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wang D., Hu B., Hu C., Zhu F., Liu X., Zhang J., Wang B., Xiang H., Cheng Z., Xiong Y., Zhao Y., Li Y., Wang X., Peng Z.",57216128324;57207150521;57214822886;57214820542;57214824706;57214827020;57214822224;55602755400;57214753403;56537471300;57215065758;27172163600;57214826973;7401790844;,"Clinical Characteristics of 138 Hospitalized Patients with 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China",2020,JAMA - Journal of the American Medical Association,323,11,,1061,1069,,151,10.1001/jama.2020.1585,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079242706&doi=10.1001%2fjama.2020.1585&partnerID=40&md5=e00ade012dee7d014efde66de893d32d,"Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, China; Department of Pulmonary Medicine, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, China; Department of Infectious Disease, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, China; Department of Emergency Medicine, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, China; Department of Laboratory Medicine, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, China; Department of Urology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, China","Wang, D., Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, China; Hu, B., Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, China; Hu, C., Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, China; Zhu, F., Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, China; Liu, X., Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, China; Zhang, J., Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, China; Wang, B., Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, China; Xiang, H., Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, China; Cheng, Z., Department of Pulmonary Medicine, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, China; Xiong, Y., Department of Infectious Disease, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, China; Zhao, Y., Department of Emergency Medicine, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, China; Li, Y., Department of Laboratory Medicine, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, China; Wang, X., Department of Urology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei, China; Peng, Z., Department of Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, 430071, China","Importance: In December 2019, novel coronavirus (2019-nCoV)-infected pneumonia (NCIP) occurred in Wuhan, China. The number of cases has increased rapidly but information on the clinical characteristics of affected patients is limited. Objective: To describe the epidemiological and clinical characteristics of NCIP. Design, Setting, and Participants: Retrospective, single-center case series of the 138 consecutive hospitalized patients with confirmed NCIP at Zhongnan Hospital of Wuhan University in Wuhan, China, from January 1 to January 28, 2020; final date of follow-up was February 3, 2020. Exposures: Documented NCIP. Main Outcomes and Measures: Epidemiological, demographic, clinical, laboratory, radiological, and treatment data were collected and analyzed. Outcomes of critically ill patients and noncritically ill patients were compared. Presumed hospital-related transmission was suspected if a cluster of health professionals or hospitalized patients in the same wards became infected and a possible source of infection could be tracked. Results: Of 138 hospitalized patients with NCIP, the median age was 56 years (interquartile range, 42-68; range, 22-92 years) and 75 (54.3%) were men. Hospital-associated transmission was suspected as the presumed mechanism of infection for affected health professionals (40 [29%]) and hospitalized patients (17 [12.3%]). Common symptoms included fever (136 [98.6%]), fatigue (96 [69.6%]), and dry cough (82 [59.4%]). Lymphopenia (lymphocyte count, 0.8 × 109/L [interquartile range {IQR}, 0.6-1.1]) occurred in 97 patients (70.3%), prolonged prothrombin time (13.0 seconds [IQR, 12.3-13.7]) in 80 patients (58%), and elevated lactate dehydrogenase (261 U/L [IQR, 182-403]) in 55 patients (39.9%). Chest computed tomographic scans showed bilateral patchy shadows or ground glass opacity in the lungs of all patients. Most patients received antiviral therapy (oseltamivir, 124 [89.9%]), and many received antibacterial therapy (moxifloxacin, 89 [64.4%]; ceftriaxone, 34 [24.6%]; azithromycin, 25 [18.1%]) and glucocorticoid therapy (62 [44.9%]). Thirty-six patients (26.1%) were transferred to the intensive care unit (ICU) because of complications, including acute respiratory distress syndrome (22 [61.1%]), arrhythmia (16 [44.4%]), and shock (11 [30.6%]). The median time from first symptom to dyspnea was 5.0 days, to hospital admission was 7.0 days, and to ARDS was 8.0 days. Patients treated in the ICU (n = 36), compared with patients not treated in the ICU (n = 102), were older (median age, 66 years vs 51 years), were more likely to have underlying comorbidities (26 [72.2%] vs 38 [37.3%]), and were more likely to have dyspnea (23 [63.9%] vs 20 [19.6%]), and anorexia (24 [66.7%] vs 31 [30.4%]). Of the 36 cases in the ICU, 4 (11.1%) received high-flow oxygen therapy, 15 (41.7%) received noninvasive ventilation, and 17 (47.2%) received invasive ventilation (4 were switched to extracorporeal membrane oxygenation). As of February 3, 47 patients (34.1%) were discharged and 6 died (overall mortality, 4.3%), but the remaining patients are still hospitalized. Among those discharged alive (n = 47), the median hospital stay was 10 days (IQR, 7.0-14.0). Conclusions and Relevance: In this single-center case series of 138 hospitalized patients with confirmed NCIP in Wuhan, China, presumed hospital-related transmission of 2019-nCoV was suspected in 41% of patients, 26% of patients received ICU care, and mortality was 4.3%. © 2020 American Medical Association. All rights reserved.",,azithromycin; ceftriaxone; glucocorticoid; lactate dehydrogenase; moxifloxacin; oseltamivir; adult; adult respiratory distress syndrome; aged; anorexia; antiviral therapy; Article; China; clinical feature; computer assisted tomography; Coronavirus disease 2019; Coronavirus infection; coughing; critically ill patient; disease transmission; dyspnea; extracorporeal oxygenation; fatigue; female; fever; follow up; health practitioner; heart arrhythmia; hospital admission; hospital infection; hospital patient; human; intensive care unit; lactate dehydrogenase blood level; length of stay; lymphocytopenia; major clinical study; male; mortality rate; noninvasive ventilation; oxygen therapy; priority journal; prothrombin time; retrospective study; risk factor; shock; virus pneumonia,"Lu, H., Stratton, C.W., Tang, Y.W., Outbreak of pneumonia of unknown etiology in Wuhan China: The mystery and the miracle (2020) J Med Virol, , http://dx.doi.org/10.1002/jmv.25678, [published January 16, 2020].. doi: 31950516; Hui, D.S., Azhar E, I., Madani, T.A., The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health: The latest 2019 novel coronavirus outbreak in Wuhan, China (2020) Int J Infect Dis, 91, pp. 264-266. , http://dx.doi.org/10.1016/j.ijid.2020.01.009, [published January 14, 2020].;:. doi: 31953166; Report of Novel Coronavirus-infected Pneumonia in China, , http://wjw.wuhan.gov.cn/front/web/showDetail/2020012009077, Wuhan Municipal Health Commission. Published January 20, 2020. Accessed January 31, 2020; Paules, C.I., Marston, H.D., Fauci, A.S., Coronavirus infections - More than just the common cold JAMA, , http://jamanetwork.com/article.aspx?doi=10.1001/jama.2020.0757, [published January 23, 2020]. doi; Report of Clustering Pneumonia of Unknown Etiology in Wuhan City, , http://wjw.wuhan.gov.cn/front/web/showDetail/2019123108989, Wuhan Municipal Health Commission. Published December 31, 2019. Accessed January 31, 2020; Novel coronavirus(2019-nCoV): Situation Report - 15, , https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200204-sitrep-15-ncov.pdf, World Health Organization. Accessed February 5, 2020; Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 N Engl J Med, , http://dx.doi.org/10.1056/NEJMoa2001017, [published January 24, 2020]. doi: 31978945; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study Lancet, , http://dx.doi.org/10.1016/S0140-6736(20)30211-7, [published January 29, 2020]. doi: 32007143; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Lancet, , http://dx.doi.org/10.1016/S0140-6736(20)30183-5, [published January 24, 2020]. doi: 31986264; Chan, J.-W., Yuan, S., Kok, K.-H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: A study of a family cluster (2020) Lancet, , http://dx.doi.org/10.1016/S0140-6736(20)30154-9, [published January 24, 2020].;; Phan, L.T., Nguyen, T.V., Luong, Q.C., Importation and human-to-human transmission of a novel coronavirus in Vietnam N Engl J Med, , http://dx.doi.org/10.1056/NEJMc2001272, [published January 28, 2020]. doi: 31991079; Clinical Management of Severe Acute Respiratory Infection When Novel Coronavirus (NCoV) Infection Is Suspected: Interim Guidance, , https://www.who.int/publications-detail/clinical-management-of-severe-acute-respiratory-infection-when-novel-coronavirus-(ncov)-infection-is-suspected, World Health Organization. Published January 28, 2020. Accessed January 31, 2020; Ranieri, V.M., Rubenfeld, G.D., Thompson, B.T., Acute respiratory distress syndrome: The Berlin definition (2012) JAMA, 307 (23), pp. 2526-2533. , http://jamanetwork.com/article.aspx?doi=10.1001/jama.2012.5669, doi: 22797452; KDIGO Clinical Practice Guideline for Acute Kidney Injury (2012) Kidney Int Suppl, 2, p. 1; Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med, , http://dx.doi.org/10.1056/NEJMoa2001316, [published on January 29, 2020].. doi: 31995857; Zhang, H., Kang, Z.J., Gong, H.Y., The Digestive System is a Potential Route of 2019 nCoV Infection: A Bioinformatics Analysis based on Single-Cell Transcriptomes, , http://dx.doi.org/10.1101/2020.01.30.927806, Preprint. Posted online January 31, 2020. bioRxiv 927806. doi; De Wit, E., Van Doremalen, N., Falzarano, D., Munster, V.J., SARS and MERS: Recent insights into emerging coronaviruses (2016) Nat Rev Microbiol, 14 (8), pp. 523-534. , http://dx.doi.org/10.1038/nrmicro.2016.81, doi: 27344959","Peng, Z.; Department of Critical Care Medicine, Zhongnan Hospital of Wuhan UniversityChina; email: pengzy5@hotmail.com",,American Medical Association,987484,,JAMAA,32031570,English,JAMA,Article,Final,Open Access,Scopus,2-s2.0-85079242706,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Jiang Z.F., Li J.B.",57215648483;57194858826;,Ten hot issues on diagnosis and treatment of breast cancer under the outbreak of novel coronavirus pneumonia,2020,Zhonghua yi xue za zhi,100,10,,721,723,,,10.3760/cma.j.cn112137-20200207-00218,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082081783&doi=10.3760%2fcma.j.cn112137-20200207-00218&partnerID=40&md5=abb920572bfb4f3b9e538159aaaf1d4d,"Fifth Medical Center of PLA General HospitalBeijing 100070, China; Beijing Institute of Biotechnology, Academy of Military Medical SciencesBeijing 100070, China","Jiang, Z.F., Fifth Medical Center of PLA General HospitalBeijing 100070, China; Li, J.B., Beijing Institute of Biotechnology, Academy of Military Medical SciencesBeijing 100070, China",[No abstract available],,,,,,NLM (Medline),3762491,,,32192284,Chinese,Zhonghua Yi Xue Za Zhi,Article,Final,,Scopus,2-s2.0-85082081783,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Yu K.Y., Shi H.P.",57215840134;57215839369;,Explanation of expert recommendations on medical nutrition for patients with novel coronavirus pneumonia,2020,Zhonghua yi xue za zhi,100,10,,724,728,,,10.3760/cma.j.cn112137-20200205-00196,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082051231&doi=10.3760%2fcma.j.cn112137-20200205-00196&partnerID=40&md5=0e7c256a44453a5f177f3782ccc7d0cf,"Department of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University/Chinese Society for Parenteral and Enteral NutritionBeijing 100038, China","Yu, K.Y., Department of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical University/Chinese Society for Parenteral and Enteral NutritionBeijing 100038, China; Shi, H.P.",[No abstract available],,,,,,NLM (Medline),3762491,,,32192285,Chinese,Zhonghua Yi Xue Za Zhi,Article,Final,,Scopus,2-s2.0-85082051231,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Del Rio C., Malani P.N.",57209777695;6602823521;,2019 Novel Coronavirus - Important Information for Clinicians,2020,JAMA - Journal of the American Medical Association,323,11,,1039,1040,,7,10.1001/jama.2020.1490,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079226451&doi=10.1001%2fjama.2020.1490&partnerID=40&md5=9c2c53bec5750f88514c9d4fb7610921,"Division of Infectious Diseases, Department of Internal Medicine, Emory University School of Medicine, 69 Jesse Hill Jr Dr, Atlanta, GA 30303, United States; Division of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, United States; JAMA, United States","Del Rio, C., Division of Infectious Diseases, Department of Internal Medicine, Emory University School of Medicine, 69 Jesse Hill Jr Dr, Atlanta, GA 30303, United States; Malani, P.N., Division of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, United States, JAMA, United States",[No abstract available],,lopinavir plus ritonavir; remdesivir; adult respiratory distress syndrome; China; comorbidity; coronavirus disease 2019; Coronavirus infection; epidemic; fever; gene sequence; health education; high throughput sequencing; human; incubation time; infection control; infection prevention; intensive care; mortality rate; nonhuman; Note; pneumonia; priority journal; quarantine; SARS coronavirus; sequence homology; Severe acute respiratory syndrome coronavirus 2; symptomatology; travel; virus identification; virus infectivity; virus transmission,"Paules, C.I., Marston, H.D., Fauci, A.S., Coronavirus infections - More than just the common cold JAMA, , http://jamanetwork.com/article.aspx?doi=10.1001/jama.2020.0757, Published online January 23, 2020. doi: 31971553; Zhou, P., Yang, X.L., Wang, X.G., Discovery of A Novel Coronavirus Associated with the Recent Pneumonia Outbreak in Humans and Its Potential Bat Origin, , https://www.biorxiv.org/content/10.1101/2020.01.22.914952v2.full.pdf, Preprint. Posted January 23, 2020. Accessed February 3, 2020; (2020) Centers for Disease Control and Prevention, , https://www.cdc.gov/coronavirus/about/index.html, Coronavirus. Accessed February 2; Wu, J.T., Leung, K., Leung, G.M., Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: A modelling study Lancet, , http://dx.doi.org/10.1016/S0140-6736(20)30260-9, Published online January 31, 2020. doi; Cohen, J., Mining coronavirus genomes for clues to the outbreak's origins Science, , http://dx.doi.org/10.1126/science.abb1256, Published online January 31, 2020. doi; Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia N Engl J Med, , http://dx.doi.org/10.1056/NEJMoa2001316, Published online January 29, 2020. doi: 31995857; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study Lancet, , http://dx.doi.org/10.1016/S0140-6736(20)30211-7, Published online January 30, 2020. doi: 32007143; Huang, C., Clinical feature of patients infected with 2019 novel coronavirus in Wuhan, China Lancet, , http://dx.doi.org/10.1016/S0140-6736(20)30183-5, Published online January 24, 2020. doi; Holshue, M.L., Debolt, C., Lindquist, S., First case of 2019 novel coronavirus in the United States N Engl J Med, , http://dx.doi.org/10.1056/NEJMoa2001191, Published online January 31, 2020. doi: 32004427; Phelan, A.L., Katz, R., Gostin, L.O., The novel coronavirus originating in Wuhan, China: Challenges for global health governance (2020) JAMA, , http://jamanetwork.com/article.aspx?doi=10.1001/jama.2020.1097, Published online January 30, doi","Del Rio, C.; Division of Infectious Diseases, Department of Internal Medicine, Emory University School of Medicine, 69 Jesse Hill Jr Dr, United States; email: cdelrio@emory.edu",,American Medical Association,987484,,JAMAA,32022836,English,JAMA,Note,Final,Open Access,Scopus,2-s2.0-85079226451,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Chang D., Lin M., Wei L., Xie L., Zhu G., Dela Cruz C.S., Sharma L.",57212582518;57214825531;57214824735;36653380900;7402632846;6602433042;55349407200;,"Epidemiologic and Clinical Characteristics of Novel Coronavirus Infections Involving 13 Patients Outside Wuhan, China",2020,JAMA - Journal of the American Medical Association,323,11,,1092,1093,,14,10.1001/jama.2020.1623,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079210890&doi=10.1001%2fjama.2020.1623&partnerID=40&md5=503423f29f03a0911450fae2eca678b9,"College of Respiratory and Critical Care Medicine, Chinese PLA General Hospital, 28 Fuxing Road, Haidian, Beijing, 100853, China; Beijing Tsinghua Changgung Hospital, Tsinghua University, School of Medicine, Beijing, China; Institute for Precision Medicine, Tsinghua University, Beijing, China; Department of Infectious Diseases, Beijing Institute of Heart, Lung and Blood Vessel Disease, Dept. of Pulmon. and Critical Care Med., Beijing Anzhen Hosp., Cap. Medical University, Two Anzhen Road, Chaoyang, Beijing, 100029, China; Section of Pulmonary and Critical Care and Sleep Medicine, Yale University, School of Medicine, New Haven, CT, United States","Chang, D., College of Respiratory and Critical Care Medicine, Chinese PLA General Hospital, 28 Fuxing Road, Haidian, Beijing, 100853, China; Lin, M., Beijing Tsinghua Changgung Hospital, Tsinghua University, School of Medicine, Beijing, China; Wei, L., Institute for Precision Medicine, Tsinghua University, Beijing, China; Xie, L., College of Respiratory and Critical Care Medicine, Chinese PLA General Hospital, 28 Fuxing Road, Haidian, Beijing, 100853, China; Zhu, G., Department of Infectious Diseases, Beijing Institute of Heart, Lung and Blood Vessel Disease, Dept. of Pulmon. and Critical Care Med., Beijing Anzhen Hosp., Cap. Medical University, Two Anzhen Road, Chaoyang, Beijing, 100029, China; Dela Cruz, C.S., Section of Pulmonary and Critical Care and Sleep Medicine, Yale University, School of Medicine, New Haven, CT, United States; Sharma, L., Section of Pulmonary and Critical Care and Sleep Medicine, Yale University, School of Medicine, New Haven, CT, United States",[No abstract available],,adult; China; clinical article; clinical feature; Coronavirus disease 2019; Coronavirus infection; disease transmission; female; follow up; human; Letter; male; mortality rate; priority journal; risk factor,"(2020) World Health Organization, , https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200204-sitrep-15-ncov.pdf?sfvrsn=88fe8ad6_2, Novel coronavirus (2019-nCoV) situation report-15. Published February 4, Accessed February 3, 2020; Paules, C.I., Marston, H.D., Fauci, A.S., Coronavirus infections - More than just the common cold JAMA, , http://jamanetwork.com/article.aspx?doi=10.1001/jama.2020.0757, [published online January 23, 2020]. doi; Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia N Engl J Med, , http://dx.doi.org/10.1056/NEJMoa2001316, [published online January 29, 2020]. doi: 31995857; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China Lancet, , http://dx.doi.org/10.1016/S0140-6736(20)30183-5, [published online January 24, 2020]. doi: 31986264; Donnelly, C.A., Ghani, A.C., Leung, G.M., Epidemiological determinants of spread of causal agent of severe acute respiratory syndrome in Hong Kong (2003) Lancet, 361 (9371), pp. 1761-1766. , http://dx.doi.org/10.1016/S0140-6736(03)13410-1, doi: 12781533; Ahmed, A.E., The predictors of 3- and 30-day mortality in 660 MERS-CoV patients (2017) BMC Infect Dis, 17 (1), p. 615. , http://dx.doi.org/10.1186/s12879-017-2712-2, doi: 28893197","Xie, L.; College of Respiratory and Critical Care Medicine, Chinese PLA General Hospital, 28 Fuxing Road, Haidian, China; email: xielx301@126.com",,American Medical Association,987484,,JAMAA,32031568,English,JAMA,Letter,Final,Open Access,Scopus,2-s2.0-85079210890,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Tanne J.H., Hayasaki E., Zastrow M., Pulla P., Smith P., Rada A.G.",57216044728;57215844073;57215842763;56349964800;57193708518;57215839610;,Covid-19: How doctors and healthcare systems are tackling coronavirus worldwide,2020,The BMJ,368,, m1086,,,,1,10.1136/bmj.m1090,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082088375&doi=10.1136%2fbmj.m1090&partnerID=40&md5=c9402a714324916ecb16a0069974238d,"New York, United States; Boston, United States; Seoul, South Korea; Bangalore, India; Sydney, Australia; Madrid, Spain","Tanne, J.H., New York, United States; Hayasaki, E., Boston, United States; Zastrow, M., Seoul, South Korea; Pulla, P., Bangalore, India; Smith, P., Sydney, Australia; Rada, A.G., Madrid, Spain",[No abstract available],,act; acute respiratory tract disease; Article; Australia; Canada; China; clinical protocol; Coronavirus infection; Covid 19; device approval; emergency care; emergency health service; Epidemics Diseases Act; Food and Drug Administration; France; funding; Germany; government; health care availability; health care facility; health care system; hospital admission; human; India; infection control; infection prevention; Iran; isolation; Italy; Japan; medicaid; medical practice; medicare; mortality rate; physician attitude; polymerase chain reaction; priority journal; public-private partnership; quarantine; SARS coronavirus; SARS coronavirus 2; social distancing; South Korea; Spain; teleconsultation; telehealth; United States; virus transmission; vulnerable population; World Health Organization,"(2020) Coronavirus Disease 2019 (COVID-19): Get Your Mass Gatherings or Large Community Events Ready for Coronavirus Disease 2019, , CDC; Kubo, T., Shrinking and super-aging suburbs in Japanese metropolis (2017) Research Gate, , https://www.researchgate.net/profile/Tomoko_Kubo3/publication/321221881_Shrinking_and_Super-Aging_Suburbs_in_Japanese_Metropolis/links/5b875356a6fdcc5f8b710d7e/Shrinking-and-Super-Aging-Suburbs-in-Japanese-Metropolis.pdf, Apr; https://www.mohfw.gov.in/, Government of India. Ministry of Health and Welfare; (2014) Future of India: The Winning Leap, , https://www.pwc.com/sg/en/publications/assets/future-of-india-the-winning-leap.pdf, PWC; How a South Korean city is changing tactics to tamp down its covid-19 surge (2020) NPR, , https://www.npr.org/sections/goatsandsoda/2020/03/10/812865169/how-a-south-koreancity-is-changing-tactics-to-tamp-down-its-covid-19-surg; Medical staff under pressure amid spiking virus cases in S. Korea (2020) Yonhap, , https://en.yna.co.kr/view/AEN20200302002551320, Mar 2; Doctors, health workers volunteer to help mitigate coronavirus crisis in Daegu, N. Gyeongsang (2020) Hankyoreh, , http://english.hani.co.kr/arti/english_edition/e_national/930202.html, Feb 27; Ministerio de Sanidad. Procedimiento de actuación frente a casos de infección por el nuevo coronavirus (SARS-CoV-2) (2020) Ministry of Health. Protocol against Cases of Infection by the New Coronavirus (SARS-CoV-2), , https://www.mscbs.gob.es/profesionales/saludPublica/ccayes/alertasActual/nCov-China/documentos/Procedimiento_COVID_19.pdf, Updated 15 Mar 2020, Actualizado a 15 de marzo de 2020; Worthington, B., Gatherings of more than 500 people to be cancelled amid coronavirus fears (2020) ABC, , https://www.abc.net.au/news/2020-03-13/coronavirus-scott-morrisoncoag-premiers-cancelling-events/12053382; Smith, P., ""Left in the dark"": 90% of GPs denied the equipment to safely test patients for COVID-19 (2020) Ausdoc, , https://www.ausdoc.com.au/news/left-dark-90-gps-deniedequipment-safely-test-patients-covid19, Mar 6; Murphy, B., Chief Medical Officer update on coronavirus testing (2020) RACGP, , https://www1.racgp.org.au/newsgp/professional/chief-medical-officer-update-oncoronavirus-testin, Mar 13; O'Rourke, G., Revealed: The rebates and rules for claiming the new GP telehealth items (2020) Ausdoc, , https://www.ausdoc.com.au/news/revealed-rebates-and-rulesclaiming-new-gp-telehealth-items, Mar 13; Papworth, T., Coronavirus: Melbourne doctor treats patients in car park (2020) Age, , https://www.theage.com.au/national/victoria/doctor-takes-to-the-carpark-to-treatcoronavirus-20200308-p5482n.html, Mar 8; Wuhan closes last makeshift coronavirus hospital as China's infection rate falls-video (2020) Guardian, , https://www.theguardian.com/world/video/2020/mar/10/wuhan-closeslast-makeshift-coronavirus-hospital-video; Barigazzi, J., Italy's foreign minister hails Chinese coronavirus aid (2020) Politico, , https://www.politico.eu/article/italys-foreign-minister-hails-chinese-caronavirus-aid/, Mar 13; Wen, X., Beijing's Xiaotangshan Hospital to open soon (2020) China Daily, , Feb 18; Macron announces a two-week lockdown in France, closure of EU's Schengen zone borders (2020) France 24, , https://www.france24.com/en/20200316-france-scoronavirus-situation-deteriorating-very-fast-health-chief-says, Mar 16; Coronavirus is France's ""greatest health crisis in a century,"" says Macron (2020) France 24, , https://www.france24.com/en/20200312-coronavirus-is-france-s-greatesthealth-crisis-in-a-century-says-macron, Mar 12; More than half of coronavirus cases in France under intensive care are below the age of 60 (2020) CNN, , https://edition.cnn.com/world/live-news/coronavirus-outbreak-03-16-20-intl-hnk/h_91b13ce4323d365087bad47c5c9a8c39, Mar 16; Picheta, R., France says ibuprofen may aggravate coronavirus. Experts say more evidence is needed (2020) CNN, , https://edition.cnn.com/2020/03/16/health/coronavirusibuprofen-french-health-minister-scn-intl-scli/index.html, Mar 17; Day, M., Covid-19: Ibuprofen should not be used for managing symptoms, say doctors and scientists (2020) BMJ, 368, p. m1086; Coronavirus: Germany latest country to close borders (2020) BBC, , https://www.bbc.co.uk/news/world-europe-51905129, Mar 16; Coronavirus: Anger in Germany at report Trump seeking exclusive vaccine deal (2020) Guardian, , https://www.theguardian.com/world/2020/mar/16/not-for-sale-anger-ingermany-at-report-trump-seeking-exclusive-coronavirus-vaccine-deal, Mar 16; Iran says worsening outbreak could strain health facilities (2020) Politico, , https://www.politico.com/news/2020/03/15/iran-says-worsening-outbreak-could-strain-healthfacilities-129895, Mar 15; (2020) Coronavirus COVID-19 Global Cases by the Center for Systems Science and Engineering, , https://coronavirus.jhu.edu/map.html, Johns Hopkins University; Bote, J., At least 44 dead from drinking toxic alcohol in Iran after coronavirus cure rumor (2020) USA Today, , https://eu.usatoday.com/story/news/world/2020/03/10/44-deadiran-drinking-toxic-alcohol-fake-coronavirus-cure/5009761002/, Mar 11; Slobodian, S.R., Evening Update: Canada closing borders to most non-citizens amid coronavirus outbreak; World markets slide again (2020) Globe and Mail, , https://www.theglobeandmail.com/canada/article-evening-update-canada-closing-borders-tomost-non-citizens-amid/, Mar 16; Canada's Chief Medical Officer Dr. Theresa Tam says government needs to ""act now"" to contain coronavirus epidemic (2020) Globe and Mail, , https://www.theglobeandmail.com/canada/article-canadas-chief-medical-officer-dr-theresa-tam-says-government-needs/, Mar 15; Countries urge citizens to return home and long trials put on hold in UK over Covid-19-as it happened (2020) Guardian, , https://www.theguardian.com/world/live/2020/mar/17/coronavirus-live-news-updates-uk-us-australia-europe-france-italy-who-self-isolationtravel-bans-borders-latest-update, Mar 18; Paterlini, M., On the front lines of coronavirus: The Italian response to covid-19 (2020) BMJ, 368, p. m1065",,,BMJ Publishing Group,9598146,,BMJOA,32188598,English,BMJ,Article,Final,Open Access,Scopus,2-s2.0-85082088375,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Mian A., Khan S.",57213153795;57211850298;,Coronavirus: the spread of misinformation,2020,BMC medicine,18,1,,89,,,,10.1186/s12916-020-01556-3,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082066056&doi=10.1186%2fs12916-020-01556-3&partnerID=40&md5=a5a05b11854ebab84079f9def1716ad7,"Imperial College London, London, SW7 2AZ, United Kingdom; Imperial College London, London, SW7 2AZ, United Kingdom","Mian, A., Imperial College London, London, SW7 2AZ, United Kingdom; Khan, S., Imperial College London, London, SW7 2AZ, United Kingdom",[No abstract available],Antiscience; Coronavirus; COVID-19; Internet; Misinformation; Pandemic; Public health,China; Coronavirinae; Coronavirus infection; human; interpersonal communication; public health; China; Communication; Coronavirus; Coronavirus Infections; Humans; Public Health,,,,NLM (Medline),17417015,,,32188445,English,BMC Med,Letter,Final,Open Access,Scopus,2-s2.0-85082066056,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Nau J.-Y.,57215126971;,Épidémie de coronavirus vs libertés individuelles,2020,Revue medicale suisse,16,686,,564,565,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082003843&partnerID=40&md5=80f1e225466e08353899541a8e48c08c,,"Nau, J.-Y.",[No abstract available],,,,,,NLM (Medline),16609379,,,32186807,French,Rev Med Suisse,Note,Final,,Scopus,2-s2.0-85082003843,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, COVID-19 National Incident Room Surveillance Team,,"COVID-19, Australia: Epidemiology Report 7 (Reporting week ending 19:00 AEDT 14 March 2020)",2020,Communicable diseases intelligence (2018),44,,,,,,,10.33321/cdi.2020.44.23,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082031190&doi=10.33321%2fcdi.2020.44.23&partnerID=40&md5=875d17c00cb897a360d482130ad5146d,,COVID-19 National Incident Room Surveillance Team,"This is the seventh epidemiological report for coronavirus disease 2019 (COVID-19), reported in Australia as at 19:00 Australian Eastern Daylight Time [AEDT] 14 March 2020. It includes data on COVID-19 cases diagnosed in Australia, the international situation and a review of current evidence. © Commonwealth of Australia CC BY-NC-ND.",2019-nCoV; acute respiratory disease; Australia; case definition; coronavirus disease 2019; COVID-19; epidemiology; novel coronavirus; SARS-CoV-2,"COVID-19; severe acute respiratory syndrome coronavirus 2; adolescent; adult; aged; Australia; Betacoronavirus; child; complication; Coronavirus infection; female; health survey; hospitalization; human; infant; isolation and purification; male; middle aged; pathogenicity; preschool child; travel; very elderly; virus pneumonia; young adult; Adolescent; Adult; Aged; Aged, 80 and over; Australia; Betacoronavirus; Child; Child, Preschool; Coronavirus Infections; Female; Hospitalization; Humans; Infant; Male; Middle Aged; Pneumonia, Viral; Population Surveillance; Travel; Young Adult",,,,NLM (Medline),22096051,,,32192424,English,Commun Dis Intell (2018),Article,Final,Open Access,Scopus,2-s2.0-85082031190,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, [No author name available],[No author id available],Coronavirus: three things all governments and their science advisers must do now,2020,Nature,579,7799,,319,320,,,10.1038/d41586-020-00772-4,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082080198&doi=10.1038%2fd41586-020-00772-4&partnerID=40&md5=98e3b6a0ccf1c5280e5eeb86348c1d86,,,"Follow World Health Organization advice, end secrecy in decision-making and cooperate globally. © 2020, Nature.",Genomics; Health care; Infection; Virology,Coronavirinae; decision making; editorial; genomics; government; nonhuman; virology; World Health Organization; Coronavirus,,,,Nature Research,280836,,NATUA,32184490,English,Nature,Editorial,Final,Open Access,Scopus,2-s2.0-85082080198,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, [No author name available],[No author id available],The Novel Coronavirus Outbreak: What We Know and What We Don't,2020,Cell,180,6,,1034,1036,,,10.1016/j.cell.2020.02.027,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081691942&doi=10.1016%2fj.cell.2020.02.027&partnerID=40&md5=c35257b607f77e54315b39eefc5a655a,,,[No abstract available],,virus spike protein; Article; China; Coronavirus infection; disease association; disease severity; epidemic; gene sequence; genetic variability; human; metagenomics; mortality rate; phylogeny; polymerase chain reaction; priority journal; public health; respiratory tract disease; risk assessment; SARS coronavirus; virus transmission; virus virulence,,,,Cell Press,928674,,CELLB,32078801,English,Cell,Article,Final,Open Access,Scopus,2-s2.0-85081691942,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Xiao H., Zhang Y., Kong D., Li S., Yang N.",57215594890;57215614444;57215608052;57215313671;57200657022;,Social Capital and Sleep Quality in Individuals Who Self-Isolated for 14 Days During the Coronavirus Disease 2019 (COVID-19) Outbreak in January 2020 in China,2020,Medical science monitor : international medical journal of experimental and clinical research,26,,,e923921,,,,10.12659/MSM.923921,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082084551&doi=10.12659%2fMSM.923921&partnerID=40&md5=63f32763aff995b6d89974e5d997472a,"Department of Respiration, Xuanwu Hospital, Capital Medical UniversityBeijing, China; College of Humanities and Social Sciences, Harbin Engineering University, Harbin, Heilongjiang, China; School of Health Sciences, Wuhan University, Wuhan, Hubei, China","Xiao, H., Department of Respiration, Xuanwu Hospital, Capital Medical UniversityBeijing, China; Zhang, Y., College of Humanities and Social Sciences, Harbin Engineering University, Harbin, Heilongjiang, China; Kong, D., College of Humanities and Social Sciences, Harbin Engineering University, Harbin, Heilongjiang, China; Li, S., School of Health Sciences, Wuhan University, Wuhan, Hubei, China; Yang, N., College of Humanities and Social Sciences, Harbin Engineering University, Harbin, Heilongjiang, China","BACKGROUND From the end of December 2019, coronavirus disease 2019 (COVID-19) began to spread in central China. Social capital is a measure of social trust, belonging, and participation. This study aimed to investigate the effects of social capital on sleep quality and the mechanisms involved in people who self-isolated at home for 14 days in January 2020 during the COVID-19 epidemic in central China. MATERIAL AND METHODS Individuals (n=170) who self-isolated at home for 14 days in central China, completed self-reported questionnaires on the third day of isolation. Individual social capital was assessed using the Personal Social Capital Scale 16 (PSCI-16) questionnaire. Anxiety was assessed using the Self-Rating Anxiety Scale (SAS) questionnaire, stress was assessed using the Stanford Acute Stress Reaction (SASR) questionnaire, and sleep was assessed using the Pittsburgh Sleep Quality Index (PSQI) questionnaire. Path analysis was performed to evaluate the relationships between a dependent variable (social capital) and two or more independent variables, using Pearson's correlation analysis and structural equation modeling (SEM). RESULTS Low levels of social capital were associated with increased levels of anxiety and stress, but increased levels of social capital were positively associated with increased quality of sleep. Anxiety was associated with stress and reduced sleep quality, and the combination of anxiety and stress reduced the positive effects of social capital on sleep quality. CONCLUSIONS During a period of individual self-isolation during the COVID-19 virus epidemic in central China, increased social capital improved sleep quality by reducing anxiety and stress.",,"COVID-19; severe acute respiratory syndrome coronavirus 2; adult; anxiety; Betacoronavirus; China; complication; Coronavirus infection; cross-sectional study; depression; epidemic; female; human; male; patient isolation; physiology; questionnaire; sleep; sleep disorder; social capital; social support; virus pneumonia; Adult; Anxiety; Betacoronavirus; China; Coronavirus Infections; Cross-Sectional Studies; Depression; Disease Outbreaks; Female; Humans; Male; Patient Isolation; Pneumonia, Viral; Sleep; Sleep Wake Disorders; Social Capital; Social Support; Surveys and Questionnaires",,,,NLM (Medline),16433750,,,32194290,English,Med. Sci. Monit.,Article,Final,,Scopus,2-s2.0-85082084551,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Kakimoto K., Kamiya H., Yamagishi T., Matsui T., Suzuki M., Wakita T.",57215863558;57215863629;57215863465;7403577146;57215863984;57215864027;,"Initial Investigation of Transmission of COVID-19 Among Crew Members During Quarantine of a Cruise Ship - Yokohama, Japan, February 2020",2020,MMWR. Morbidity and mortality weekly report,69,11,,312,313,,,10.15585/mmwr.mm6911e2,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082143020&doi=10.15585%2fmmwr.mm6911e2&partnerID=40&md5=bd9a6923abd944da20b7a3e7cf5fcb6c,,"Kakimoto, K.; Kamiya, H.; Yamagishi, T.; Matsui, T.; Suzuki, M.; Wakita, T.","An outbreak of coronavirus disease 2019 (COVID-19) among passengers and crew on a cruise ship led to quarantine of approximately 3,700 passengers and crew that began on February 3, 2020, and lasted for nearly 4 weeks at the Port of Yokohama, Japan (1). By February 9, 20 cases had occurred among the ship's crew members. By the end of quarantine, approximately 700 cases of COVID-19 had been laboratory-confirmed among passengers and crew. This report describes findings from the initial phase of the cruise ship investigation into COVID-19 cases among crew members during February 4-12, 2020.",,"COVID-19; Coronavirus infection; epidemic; human; Japan; quarantine; ship; virus pneumonia; Coronavirus Infections; Disease Outbreaks; Humans; Japan; Pneumonia, Viral; Quarantine; Ships",,,,NLM (Medline),1545861X,,,32191689,English,MMWR Morb. Mortal. Wkly. Rep.,Article,Final,Open Access,Scopus,2-s2.0-85082143020,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Liu K.,57215844906;,How I faced my coronavirus anxiety,2020,Science,367,6484,,1398,,,,10.1126/science.367.6484.1398,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082091219&doi=10.1126%2fscience.367.6484.1398&partnerID=40&md5=0d600b4dd4b6aca54011a50431d01a2f,"Jiangsu Normal University, Xuzhou, China","Liu, K., Jiangsu Normal University, Xuzhou, China",[No abstract available],,"anxiety; China; Coronavirinae; coronavirus disease 2019; Coronavirus infection; human; Note; personal experience; philosophy; priority journal; severe acute respiratory syndrome coronavirus 2; teaching; communicable disease control; Coronavirus infection; education; psychology; university; virus pneumonia; Coronavirus; COVID-19; Anxiety; China; Communicable Disease Control; Coronavirus Infections; Education, Distance; Faculty; Humans; Pneumonia, Viral; Teaching; Universities",,"Liu, K.; Jiangsu Normal UniversityChina; email: SciCareerEditor@aaas.org",,American Association for the Advancement of Science,368075,,SCIEA,32193330,English,Sci.,Note,Final,Open Access,Scopus,2-s2.0-85082091219,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Servick K., Cho A., Couzin-Frankel J., Guglielmi G.",55810927800;57215844416;57208764264;57197792771;,Coronavirus disruptions reverberate through research,2020,Science,367,6484,,1289,1290,,,10.1126/science.367.6484.1289,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082035786&doi=10.1126%2fscience.367.6484.1289&partnerID=40&md5=de26e5fe2c816e6acb4da9ba8daaccef,"Cambridge, MA, United States","Servick, K.; Cho, A.; Couzin-Frankel, J.; Guglielmi, G., Cambridge, MA, United States",[No abstract available],,"disease spread; research method; viral disease; virus; coronavirus disease 2019; Coronavirus infection; global health; health care facility; health hazard; human; medical research; pandemic; priority journal; restriction site; Short Survey; travel; travel restriction; United States; virus strain; clinical trial (topic); Coronavirus infection; pandemic; research; virus pneumonia; Coronavirus; COVID-19; Biomedical Research; Clinical Trials as Topic; Coronavirus Infections; Humans; Pandemics; Pneumonia, Viral; Research; Travel",,,,American Association for the Advancement of Science,368075,,SCIEA,32193300,English,Sci.,Short Survey,Final,,Scopus,2-s2.0-85082035786,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Ng Y., Li Z., Chua Y.X., Chaw W.L., Zhao Z., Er B., Pung R., Chiew C.J., Lye D.C., Heng D., Lee V.J.",57208325803;57215864182;57215863776;57215863991;57215863449;57215864017;57211477800;57216086172;14016391200;57215863872;57216110803;,"Evaluation of the Effectiveness of Surveillance and Containment Measures for the First 100 Patients with COVID-19 in Singapore - January 2-February 29, 2020",2020,MMWR. Morbidity and mortality weekly report,69,11,,307,311,,,10.15585/mmwr.mm6911e1,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082144428&doi=10.15585%2fmmwr.mm6911e1&partnerID=40&md5=8663311df4790aed1d2148a920b51ff8,,"Ng, Y.; Li, Z.; Chua, Y.X.; Chaw, W.L.; Zhao, Z.; Er, B.; Pung, R.; Chiew, C.J.; Lye, D.C.; Heng, D.; Lee, V.J.","Coronavirus disease 2019 (COVID-19) was first reported in Wuhan, China, in December 2019, and has since spread globally, resulting in >95,000 confirmed COVID-19 cases worldwide by March 5, 2020 (1). Singapore adopted a multipronged surveillance strategy that included applying the case definition at medical consults, tracing contacts of patients with laboratory-confirmed COVID-19, enhancing surveillance among different patient groups (all patients with pneumonia, hospitalized patients in intensive care units [ICUs] with possible infectious diseases, primary care patients with influenza-like illness, and deaths from possible infectious etiologies), and allowing clinician discretion (i.e., option to order a test based on clinical suspicion, even if the case definition was not met) to identify COVID-19 patients. Containment measures, including patient isolation and quarantine, active monitoring of contacts, border controls, and community education and precautions, were performed to minimize disease spread. As of March 5, 2020, a total of 117 COVID-19 cases had been identified in Singapore. This report analyzes the first 100 COVID-19 patients in Singapore to determine the effectiveness of the surveillance and containment measures. COVID-19 patients were classified by the primary means by which they were detected. Application of the case definition and contact tracing identified 73 patients, 16 were detected by enhanced surveillance, and 11 were identified by laboratory testing based on providers' clinical discretion. Effectiveness of these measures was assessed by calculating the 7-day moving average of the interval from symptom onset to isolation in hospital or quarantine, which indicated significant decreasing trends for both local and imported COVID-19 cases. Rapid identification and isolation of cases, quarantine of close contacts, and active monitoring of other contacts have been effective in suppressing expansion of the outbreak and have implications for other countries experiencing outbreaks.",,"COVID-19; adult; Coronavirus infection; epidemic; female; health survey; human; male; middle aged; procedures; Singapore; virus pneumonia; Adult; Coronavirus Infections; Disease Outbreaks; Female; Humans; Male; Middle Aged; Pneumonia, Viral; Population Surveillance; Singapore",,,,NLM (Medline),1545861X,,,32191691,English,MMWR Morb. Mortal. Wkly. Rep.,Article,Final,Open Access,Scopus,2-s2.0-85082144428,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Loeb J.,57202432191;,News & Reports EMS to stop during coronavirus outbreak,2020,Veterinary Record,186,11,,334,,,,10.1136/vr.m1122,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082145778&doi=10.1136%2fvr.m1122&partnerID=40&md5=d9032de199ac6b5b33011246430cc87c,,"Loeb, J.",[No abstract available],,coronavirus disease 19; Coronavirus infection; course content; human; medical education; Note; pandemic; safety; United Kingdom; veterinary student,,,,British Veterinary Association,424900,,VETRA,32198239,English,Vet. Rec.,Note,Final,Open Access,Scopus,2-s2.0-85082145778,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wu Y., Ho W., Huang Y., Jin D.-Y., Li S., Liu S.-L., Liu X., Qiu J., Sang Y., Wang Q., Yuen K.-Y., Zheng Z.-M.",7406891274;57215696483;57215696517;57215688646;57215686094;57215683376;55553738016;55801547200;10239926800;57215692011;57216110275;7403007092;,SARS-CoV-2 is an appropriate name for the new coronavirus,2020,The Lancet,395,10228,,949,950,,,10.1016/S0140-6736(20)30557-2,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081669799&doi=10.1016%2fS0140-6736%2820%2930557-2&partnerID=40&md5=1766d47953d44dbaa80807d656d8197c,"National Center for Biodefense and Infectious Diseases, School of Systems Biology, George Mason University, Manassas, VA 20110, United States; Department of Pathology & Laboratory Medicine and Department of Anatomy & Cell Biology, Temple University Lewis Katz School of Medicine, Philadelphia, PA, United States; Institute of Preventive Veterinary Medicine, Key Laboratory of Animal Virology of Ministry of Agriculture, College of Animal Sciences, Zhejiang University, Hangzhou, China; School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China; Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China; Department of Epidemiology, Wuhan University School of Health Sciences, Wuhan, Hubei, China; Infectious Diseases Institute, Center for Retrovirus Research, Departments of Veterinary Biosciences, Microbial Infection and Immunity, and Microbiology, The Ohio State University, Columbus, OH, United States; Food Animal Health Research Program, Department of Veterinary Preventive Medicine, The Ohio State University, Wooster, OH, United States; Department of Pathology, Georgetown University Medical Center, Washington, DC, United States; Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, KS, United States; Department of Agricultural and Environmental Sciences, College of Agriculture, Human and Natural Sciences, Tennessee State University, Nashville, TN, United States; Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, United States","Wu, Y., National Center for Biodefense and Infectious Diseases, School of Systems Biology, George Mason University, Manassas, VA 20110, United States; Ho, W., Department of Pathology & Laboratory Medicine and Department of Anatomy & Cell Biology, Temple University Lewis Katz School of Medicine, Philadelphia, PA, United States; Huang, Y., Institute of Preventive Veterinary Medicine, Key Laboratory of Animal Virology of Ministry of Agriculture, College of Animal Sciences, Zhejiang University, Hangzhou, China; Jin, D.-Y., School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China; Li, S., Department of Epidemiology, Wuhan University School of Health Sciences, Wuhan, Hubei, China; Liu, S.-L., Infectious Diseases Institute, Center for Retrovirus Research, Departments of Veterinary Biosciences, Microbial Infection and Immunity, and Microbiology, The Ohio State University, Columbus, OH, United States; Liu, X., Department of Pathology, Georgetown University Medical Center, Washington, DC, United States; Qiu, J., Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, KS, United States; Sang, Y., Department of Agricultural and Environmental Sciences, College of Agriculture, Human and Natural Sciences, Tennessee State University, Nashville, TN, United States; Wang, Q., Food Animal Health Research Program, Department of Veterinary Preventive Medicine, The Ohio State University, Wooster, OH, United States; Yuen, K.-Y., Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China; Zheng, Z.-M., Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, United States",[No abstract available],,"clinical practice; disease re-emergence; economic development; human; Letter; Middle East respiratory syndrome; nomenclature; nonhuman; phylogeny; prediction; priority journal; SARS coronavirus; severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; social aspect; standardization; taxonomy; virus genome; virus identification; virus strain; virus transmission; World Health Organization; Betacoronavirus; Coronavirinae; Coronavirus infection; virus pneumonia; Betacoronavirus; Coronavirus; Coronavirus Infections; Humans; Pneumonia, Viral; SARS Virus","Jiang, S., Shi, Z., Shu, Y., A distinct name is needed for the new coronavirus (2020) Lancet, , published online Feb 19; Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382, pp. 727-733; Gorbalenya, A.E., Baker, S.C., Baric, R.S., Severe acute respiratory syndrome-related coronavirus: the species and its viruses - a statement of the Coronavirus Study Group (2020) bioRxiv, , published online Feb 11. (preprint); Simmonds, P., Adams, M.J., Benko, M., Consensus statement: virus taxonomy in the age of metagenomics (2017) Nat Rev Microbiol, 15, pp. 161-168; Lauber, C., Gorbalenya, A.E., Partitioning the genetic diversity of a virus family: approach and evaluation through a case study of picornaviruses (2012) J Virol, 86, pp. 3890-3904; Sharif-Yakan, A., Kanj, S.S., Emergence of MERS-CoV in the Middle East: origins, transmission, treatment, and perspectives (2014) PLoS Pathog, 10",,,Lancet Publishing Group,1406736,,LANCA,32151324,English,Lancet,Letter,Final,Open Access,Scopus,2-s2.0-85081669799,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Jiang S., Shi Z., Shu Y., Song J., Gao G.F., Tan W., Guo D.",57215679924;7403733955;57215684917;23098159000;57216110434;57203643436;57203942550;,A distinct name is needed for the new coronavirus,2020,The Lancet,395,10228,,949,,,3,10.1016/S0140-6736(20)30419-0,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081537602&doi=10.1016%2fS0140-6736%2820%2930419-0&partnerID=40&md5=84a459eaf9ca9924f6d02235285bcc25,"School of Basic Medical Sciences, Fudan University, Shanghai, China; Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China; School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, China; China Center for Disease Control and Prevention, Beijing, China; School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China","Jiang, S., School of Basic Medical Sciences, Fudan University, Shanghai, China; Shi, Z., Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China; Shu, Y., School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, China; Song, J., China Center for Disease Control and Prevention, Beijing, China; Gao, G.F., China Center for Disease Control and Prevention, Beijing, China; Tan, W., China Center for Disease Control and Prevention, Beijing, China; Guo, D., School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China",[No abstract available],,"clinical feature; clinical outcome; Coronavirinae; Coronavirus infection; disease transmission; economic development; epidemiological data; gene sequence; human; Letter; phylogeny; priority journal; public health; severe acute respiratory syndrome; virology; Betacoronavirus; classification; nomenclature; virus pneumonia; Betacoronavirus; Coronavirus Infections; Humans; Phylogeny; Pneumonia, Viral; Terminology as Topic","Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, , published online Jan 24; Zhou, P., Yang, X.L., Wang, X.G., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature, , published online Feb 3; Wu, F., Zhao, S., Yu, B., A new coronavirus associated with human respiratory disease in China (2020) Nature, , published online Feb 3; Coronavirus disease (2019), https://www.who.int/emergencies/diseases/novel-coronavirus-2019, (Accessed 18 February 2020); Gorbalenya, A.E., Baker, S.C., Baric, R.S., Severe acute respiratory syndrome-related coronavirus: the species and its viruses—a statement of the Coronavirus Study Group (2020) bioRxiv, , published online Feb 11. DOI: 2020.02.07.937862 (preprint); Alltucker, K., O'Donnell, J., When will the threat of coronavirus end? It might return every winter (2020), https://www.usatoday.com/story/news/health/2020/02/06/coronavirus-wuhan-china-recurring-winter-illness-flu/4665482002/, (Accessed 18 February 2020)",,,Lancet Publishing Group,1406736,,LANCA,32087125,English,Lancet,Letter,Final,Open Access,Scopus,2-s2.0-85081537602,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Park J.Y., Han M.S., Park K.U., Kim J.Y., Choi E.H.",57022396700;57212748007;57215844565;57210981591;57214136622;,First pediatric case of coronavirus disease 2019 in Korea,2020,Journal of Korean Medical Science,35,11, e124,,,,1,10.3346/jkms.2020.35.e124,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082063693&doi=10.3346%2fjkms.2020.35.e124&partnerID=40&md5=060b0b70e6b220bcc224d44f89918115,"Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, South Korea; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, South Korea; Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea; Department of Radiology, Seoul National University Bundang Hospital, Seongnam, South Korea; Department of Pediatrics, Seoul National University College of Medicine, Seoul, South Korea; Department of Pediatrics, Chung-Ang University Hospital, Seoul, South Korea; Department of Pediatrics, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, South Korea","Park, J.Y., Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, South Korea, Department of Pediatrics, Chung-Ang University Hospital, Seoul, South Korea; Han, M.S., Department of Pediatrics, Seoul National University Children's Hospital, Seoul, South Korea, Department of Pediatrics, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, South Korea; Park, K.U., Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea; Kim, J.Y., Department of Radiology, Seoul National University Bundang Hospital, Seongnam, South Korea; Choi, E.H., Department of Pediatrics, Seoul National University Children's Hospital, Seoul, South Korea, Department of Pediatrics, Seoul National University College of Medicine, Seoul, South Korea","The large outbreak of coronavirus disease 2019 (COVID-19) that started in Wuhan, China has now spread to many countries worldwide. Current epidemiologic knowledge suggests that relatively few cases are seen among children, which limits opportunities to address pediatric specific issues on infection control and the children's contribution to viral spread in the community. Here, we report the first pediatric case of COVID-19 in Korea. The 10-year-old girl was a close contact of her uncle and mother who were confirmed to have COVID-19. In this report, we present mild clinical course of her pneumonia that did not require antiviral treatment and serial viral test results from multiple specimens. Lastly, we raise concerns on the optimal strategy of self-quarantine and patient care in a negative isolation room for children. © 2020 The Korean Academy of Medical Sciences.",Children; Coronavirus; COVID-19; SARS-CoV-2,"COVID-19; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; case report; child; Coronavirus infection; diagnostic imaging; female; human; isolation and purification; lung; South Korea; virus pneumonia; Betacoronavirus; Child; Coronavirus Infections; Female; Humans; Lung; Pneumonia, Viral; Republic of Korea","Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382 (8), pp. 727-733; Coronavirus disease (COVID-19) situation report-41 (2020), https://www.who.int/ emergencies/diseases/novel-coronavirus-2019/situation-reports, Updated 2020. Accessed March 2; Coronavirus disease (COVID-19) situation report-39 (2020), https://www.who.int/ emergencies/diseases/novel-coronavirus-2019/situation-reports, Updated 2020. Accessed March 2; Wu, Z., McGoogan, J.M., Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention (2020) JAMA. Forthcoming; Shen, K., Yang, Y., Wang, T., Zhao, D., Jiang, Y., Jin, R., Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts' consensus statement (2020) World J Pediatr. Forthcoming; Wang, D., Ju, X.L., Xie, F., Lu, Y., Li, F.Y., Huang, H.H., Clinical analysis of 31 cases of 2019 novel coronavirus infection in children from six provinces (autonomous region) of northern China (2020) Zhonghua Er Ke Za Zhi, 58 (4), p. E011. , Chinese; Denison, M.R., Severe acute respiratory syndrome coronavirus pathogenesis, disease and vaccines: an update (2004) Pediatr Infect Dis J, 23 (11), pp. S207-S214; Memish, Z.A., Al-Tawfiq, J.A., Assiri, A., AlRabiah, F.A., Al Hajjar, S., Albarrak, A., Middle East respiratory syndrome coronavirus disease in children (2014) Pediatr Infect Dis J, 33 (9), pp. 904-906; Thabet, F., Chehab, M., Bafaqih, H., Al Mohaimeed, S., Middle East respiratory syndrome coronavirus in children (2015) Saudi Med J, 36 (4), pp. 484-486; Lambert, L., Culley, F.J., Innate immunity to respiratory infection in early life (2017) Front Immunol, 8, p. 1570; The updates of COVID-19 in the Republic of Korea (2020), https://www.cdc.go.kr/board/board.es?mid=a30402000000&bid=0030, Updated 2020. Accessed March 1; Monto, A.S., Davenport, F.M., Napier, J.A., Francis, T., Jr., Modification of an outbreak of influenza in Tecumseh, Michigan by vaccination of schoolchildren (1970) J Infect Dis, 122 (1), pp. 16-25; Feng, K., Yun, Y.X., Wang, X.F., Yang, G.D., Zheng, Y.J., Lin, C.M., Analysis of CT features of 15 children with 2019 novel coronavirus infection (2020) Zhonghua Er Ke Za Zhi, 58, p. E007. , Chinese; Chung, M., Bernheim, A., Mei, X., Zhang, N., Huang, M., Zeng, X., CT imaging features of 2019 novel coronavirus (2019-nCoV) (2020) Radiology, p. 200230; Ai, T., Yang, Z., Hou, H., Zhan, C., Chen, C., Lv, W., Correlation of chest CT and RT-PCR testing in coronavirus disease 2019 (COVID-19) in China: a report of 1014 cases (2020) Radiology, p. 200642; Management guideline for children and adolescents on COVID-19 (2020), http://ncov.mohw.go.kr/guideBoardView.do?brdId=3&brdGubun=35&dataGubun=&ncvContSeq=652&contSeq=652&board_id#, Accessed March 1, Korean","Choi, E.H.; Department of Pediatrics, Seoul National University Children's Hospital, 101 Daehak-ro, Jongno-gu, South Korea; email: eunchoi@snu.ac.kr",,Korean Academy of Medical Science,10118934,,JKMSE,32193905,English,J. Korean Med. Sci.,Article,Final,Open Access,Scopus,2-s2.0-85082063693,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Li D.K.T., Zhu S.",7405320848;57216082108;,Contributions and challenges of general practitioners in China fighting against the novel coronavirus crisis,2020,Family Medicine and Community Health,8,2, e000361,,,,,10.1136/fmch-2020-000361,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082549015&doi=10.1136%2ffmch-2020-000361&partnerID=40&md5=3b3ed73fda4982f2bfdbc7288af8ec69,"World Organisation of Family Doctors (WONCA), Hong Kong; Cross-Straits Medicine Exchange Association - Committee of General Practice, Hong Kong","Li, D.K.T., World Organisation of Family Doctors (WONCA), Hong Kong; Zhu, S., Cross-Straits Medicine Exchange Association - Committee of General Practice, Hong Kong",[No abstract available],family nurse practitioners,,"(2020) Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19) [Internet], , https://www.who.int/docs/default-source/coronaviruse/who-chinajoint-mission-on-covid-19-final-report.pdf, Who. int, [Accessed 16 Mar 2020]; Li, L., Zhong, C., Mei, J., Effect of family practice contract services on the quality of primary care in Guangzhou, China: A cross-sectional study using PCAT-AE (2018) BMJ Open, 8; (2020) Family Doctors the Future of China's Healthcare System [Internet], , https://www.chinadaily.com.cn/china/2016-02/26/content_23657040.htm, [Accessed 16 Mar 2020]","Li, D.K.T.; World Organisation of Family Doctors (WONCA)Hong Kong; email: dr2318@hotmail.com",,BMJ Publishing Group,23056983,,,,English,Fam. Med. Community Health,Note,Final,Open Access,Scopus,2-s2.0-85082549015,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Choe Y.J., Choi E.H.",36859299800;57214136622;,Are we ready for coronavirus disease 2019 arriving at schools?,2020,Journal of Korean Medical Science,35,11, e127,,,,,10.3346/jkms.2020.35.e127,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082073878&doi=10.3346%2fjkms.2020.35.e127&partnerID=40&md5=d13a90143773b8eee1896e5933e6d942,"Department of Social and Preventive Medicine, Hallym University College of Medicine, Chuncheon, South Korea; Department of Pediatrics, Seoul National University College of Medicine, Seoul, South Korea","Choe, Y.J., Department of Social and Preventive Medicine, Hallym University College of Medicine, Chuncheon, South Korea; Choi, E.H., Department of Pediatrics, Seoul National University College of Medicine, Seoul, South Korea",[No abstract available],,"COVID-19; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; communicable disease control; Coronavirus infection; epidemic; human; procedures; school; South Korea; virus pneumonia; Betacoronavirus; Communicable Disease Control; Coronavirus Infections; Disease Outbreaks; Humans; Pneumonia, Viral; Republic of Korea; Schools","Guan, W.J., Ni, Z.Y., Hu, Y., Liang, W.H., Ou, C.Q., He, J.X., Clinical characteristics of coronavirus disease 2019 in China (2020) N Engl J Med. Forthcoming; Wu, Z., McGoogan, J.M., Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention (2020) JAMA, , Forthcoming; Park, J.Y., Han, M.S., Park, K.U., Kim, J.Y., Choi, E.H., First pediatric case of coronavirus disease 2019 in Korea (2020) J Korean Med Sci, 35 (11), p. e124; Holloway, R., Rasmussen, S.A., Zaza, S., Cox, N.J., Jernigan, D.B., Updated preparedness and response framework for influenza pandemics (2014) MMWR Recomm Rep, 63 (RR-06), pp. 1-18; Ferguson, N.M., Cummings, D.A., Fraser, C., Cajka, J.C., Cooley, P.C., Burke, D.S., Strategies for mitigating an influenza pandemic (2006) Nature, 442 (7101), pp. 448-452; Markel, H., Lipman, H.B., Navarro, J.A., Sloan, A., Michalsen, J.R., Stern, A.M., Nonpharmaceutical interventions implemented by US cities during the 1918-1919 influenza pandemic (2007) JAMA, 298 (6), pp. 644-654; Jackson, C., Mangtani, P., Hawker, J., Olowokure, B., Vynnycky, E., The effects of school closures on influenza outbreaks and pandemics: systematic review of simulation studies (2014) PLoS One, 9 (5), p. e97297; Coronavirus disease (2019), http://ncov.mohw.go.kr/, Updated 2020. Accessed March 14, 2020; Bai, Y., Yao, L., Wei, T., Tian, F., Jin, D.Y., Chen, L., Presumed asymptomatic carrier transmission of COVID-19 (2020) JAMA, , Forthcoming; Bi, Q., Wu, Y., Mei, S., Ye, C., Zou, X., Zhang, Z., Epidemiology and transmission of COVID-19 in Shenzhen China: analysis of 391 cases and 1,286 of their close contacts (2020) medRxiv; (2020), https://www.cdc.gov/coronavirus/2019-ncov/downloads/considerations-for-school-closure.pdf, Updated 2020. Accessed March 14","Choi, E.H.; Department of Pediatrics, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, South Korea; email: eunchoi@snu.ac.kr",,Korean Academy of Medical Science,10118934,,JKMSE,32193906,English,J. Korean Med. Sci.,Article,Final,Open Access,Scopus,2-s2.0-85082073878,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Kwon K.T., Ko J.-H., Shin H., Sung M., Kim J.Y.",57215846056;55804188300;57215843610;56108483100;57211142178;,Drive-through screening center for covid-19: A safe and efficient screening system against massive community outbreak,2020,Journal of Korean Medical Science,35,11, e123,,,,,10.3346/jkms.2020.35.e123,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082060859&doi=10.3346%2fjkms.2020.35.e123&partnerID=40&md5=32b448955391855e648f05868b9bf049,"Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea; Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; Department of Emergency Medicine, Soonchunhyang University Hospital, Bucheon, South Korea; Department of Architectural Engineering, Sejong University, Seoul, South Korea; Division of Infectious Diseases, Department of Internal Medicine, Incheon Medical Center, Incheon, South Korea","Kwon, K.T., Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea; Ko, J.-H., Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; Shin, H., Department of Emergency Medicine, Soonchunhyang University Hospital, Bucheon, South Korea; Sung, M., Department of Architectural Engineering, Sejong University, Seoul, South Korea; Kim, J.Y., Division of Infectious Diseases, Department of Internal Medicine, Incheon Medical Center, Incheon, South Korea","As the coronavirus disease 2019 (COVID-19) outbreak is ongoing, the number of individuals to be tested for COVID-19 is rapidly increasing. For safe and efficient screening for COVID-19, drive-through (DT) screening centers have been designed and implemented in Korea. Herein, we present the overall concept, advantages, and limitations of the COVID-19 DT screening centers. The steps of the DT centers include registration, examination, specimen collection, and instructions. The entire service takes about 10 minutes for one testee without leaving his or her cars. Increased testing capacity over 100 tests per day and prevention of cross-infection between testees in the waiting space are the major advantages, while protection of staff from the outdoor atmosphere is challenging. It could be implemented in other countries to cope with the global COVID-19 outbreak and transformed according to their own situations. © 2020 The Korean Academy of Medical Sciences.",COVID-19; Drive-through; Outbreak; SARS-CoV-2; Screening,"COVID-19; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; car; communicable disease control; Coronavirus infection; human; mass screening; procedures; South Korea; virus pneumonia; Automobiles; Betacoronavirus; Communicable Disease Control; Coronavirus Infections; Humans; Mass Screening; Pneumonia, Viral; Republic of Korea","Coronavirus disease 2019 (COVID-19) Situation Report-48 (2020), https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200308-sitrep-48-covid-19.pdf?sfvrsn=16f7ccef_4, Updated 2020. Accessed March 9; Report on the epidemiological features of coronavirus disease 2019 (COVID-19) outbreak in the Republic of Korea from January 19 to March 2, 2020 (2020) J Korean Med Sci, 35 (10), p. e112. , Korean Society of Infectious DiseasesKorean Society of Pediatric Infectious DiseasesKorean Society of EpidemiologyKorean Society for Antimicrobial TherapyKorean Society for Healthcare-associated Infection Control and PreventionKorea Centers for Disease Control and Prevention; Baccam, P., Willauer, D., Krometis, J., Ma, Y., Sen, A., Boechler, M., Mass prophylaxis dispensing concerns: traffic and public access to PODs (2011) Biosecur Bioterror, 9 (2), pp. 139-151; Weiss, E.A., Ngo, J., Gilbert, G.H., Quinn, J.V., Drive-through medicine: a novel proposal for rapid evaluation of patients during an influenza pandemic (2010) Ann Emerg Med, 55 (3), pp. 268-273; Rational use of personal protective equipment for coronavirus disease 2019 (COVID-19) (2020), https://apps.who.int/iris/bitstream/handle/10665/331215/WHO-2019-nCov-IPCPPE_use-2020.1-eng.pdf, Interim guiance 27 February 2020. Updated 2020. Accessed March 9; Radonovich L.J, Jr., Cheng, J., Shenal, B.V., Hodgson, M., Bender, B.S., Respirator tolerance in health care workers (2009) JAMA, 301 (1), pp. 36-38; Laboratory testing for 2019 novel coronavirus (2019-nCoV) in suspected human cases (2020), https://www.who.int/publications-detail/laboratory-testing-for-2019-novel-coronavirus-in-suspected-human-cases-20200117, Updated 2020. Accessed March 9; Sehulster, L., Guidelines for environmental infection control in health-care facilities. Recommendations of CDC and the Healthcare Infection Control Practices Advisory Committee (HICPAC) (2003) MMWR Recomm Rep, 52 (RR-10), pp. 1-42","Kwon, K.T.; Department of Internal Medicine, School of Medicine, Kyungpook National University, 217 Bangchuk-ro, Dong-gu, South Korea; email: kjykey@gmail.com",,Korean Academy of Medical Science,10118934,,JKMSE,32193904,English,J. Korean Med. Sci.,Article,Final,Open Access,Scopus,2-s2.0-85082060859,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "de Wit E., Feldmann F., Cronin J., Jordan R., Okumura A., Thomas T., Scott D., Cihlar T., Feldmann H.",22834240700;12771883300;57193644061;8948148800;55844839600;55444919300;54387473900;6701481609;7202115850;,Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection,2020,Proceedings of the National Academy of Sciences of the United States of America,117,12,,6771,6776,,3,10.1073/pnas.1922083117,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081590720&doi=10.1073%2fpnas.1922083117&partnerID=40&md5=77665794a847a0176668654943bd1539,"Laboratory of Virology, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840, United States; Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840, United States; Biology Department, Gilead Sciences, Foster City, CA 94404, United States; Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY 10032, United States","de Wit, E., Laboratory of Virology, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840, United States; Feldmann, F., Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840, United States; Cronin, J., Laboratory of Virology, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840, United States; Jordan, R., Biology Department, Gilead Sciences, Foster City, CA 94404, United States; Okumura, A., Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY 10032, United States; Thomas, T., Laboratory of Virology, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840, United States; Scott, D., Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840, United States; Cihlar, T., Biology Department, Gilead Sciences, Foster City, CA 94404, United States; Feldmann, H., Laboratory of Virology, National Institute of Allergy and Infectious Diseases, NIH, Hamilton, MT 59840, United States","The continued emergence of Middle East Respiratory Syndrome (MERS) cases with a high case fatality rate stresses the need for the availability of effective antiviral treatments. Remdesivir (GS-5734) effectively inhibited MERS coronavirus (MERS-CoV) replication in vitro, and showed efficacy against Severe Acute Respiratory Syndrome (SARS)-CoV in a mouse model. Here, we tested the efficacy of prophylactic and therapeutic remdesivir treatment in a nonhuman primate model of MERS-CoV infection, the rhesus macaque. Prophylactic remdesivir treatment initiated 24 h prior to inoculation completely prevented MERS-CoV−induced clinical disease, strongly inhibited MERS-CoV replication in respiratory tissues, and prevented the formation of lung lesions. Therapeutic remdesivir treatment initiated 12 h postinoculation also provided a clear clinical benefit, with a reduction in clinical signs, reduced virus replication in the lungs, and decreased presence and severity of lung lesions. The data presented here support testing of the efficacy of remdesivir treatment in the context of a MERS clinical trial. It may also be considered for a wider range of coronaviruses, including the currently emerging novel coronavirus 2019-nCoV. © 2020 National Academy of Sciences. All rights reserved.",Animal model; Antiviral; MERS-CoV; Remdesivir; Therapy,,"Coronavirus Infections, , https://www.who.int/csr/don/archive/disease/coronavirus_infections/en/, Accessed 25 January 2020; Modjarrad, K., A roadmap for MERS-CoV research and product development: Report from a World Health Organization consultation (2016) Nat. Med., 22, pp. 701-705; Brende, B., CEPI-a new global R&D organisation for epidemic preparedness and response (2017) Lancet, 389, pp. 233-235; Lo, M.K., GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses (2017) Sci. Rep., 7, p. 43395; Warren, T.K., Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys (2016) Nature, 531, pp. 381-385; Lo, M.K., Remdesivir (GS-5734) protects African green monkeys from Nipah virus challenge (2019) Sci. Transl. Med., 11; Sheahan, T.P., Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses (2017) Sci. Transl. Med., 9; Sheahan, T.P., Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV (2020) Nat. Commun., 11, p. 222; Agostini, M.L., Coronavirus susceptibility to the antiviral remdesivir (GS-5734) is mediated by the viral polymerase and the proofreading exoribonuclease (2018) MBio, 9, pp. e00221-e00318; de Wit, E., Middle East respiratory syndrome coronavirus (MERS-CoV) causes transient lower respiratory tract infection in rhesus macaques (2013) Proc. Natl. Acad. Sci. U.S.A., 110, pp. 16598-16603; Hui, D.S., Middle East respiratory syndrome coronavirus: Risk factors and determinants of primary, household, and nosocomial transmission (2018) Lancet Infect. Dis., 18, pp. e217-e227; Assiri, A., Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: A descriptive study (2013) Lancet Infect. Dis., 13, pp. 752-761; Chan, J.F., Treatment with lopinavir/ritonavir or interferon-β1b improves outcome of MERS-CoV infection in a nonhuman primate model of common marmoset (2015) J. Infect. Dis., 212, pp. 1904-1913; Chen, Z., Human neutralizing monoclonal antibody inhibition of Middle East respiratory syndrome coronavirus replication in the common marmoset (2017) J. Infect. Dis., 215, pp. 1807-1815; de Wit, E., Prophylactic and therapeutic efficacy of mAb treatment against MERS-CoV in common marmosets (2018) Antiviral Res, 156, pp. 64-71; Falzarano, D., Treatment with interferon-α2b and ribavirin improves outcome in MERS-CoV-infected rhesus macaques (2013) Nat. Med., 19, pp. 1313-1317; van Doremalen, N., Efficacy of antibody-based therapies against Middle East respiratory syndrome coronavirus (MERS-CoV) in common marmosets (2017) Antiviral Res, 143, pp. 30-37; Al-Abdely, H.M., Middle East respiratory syndrome coronavirus infection dynamics and antibody responses among clinically diverse patients, Saudi Arabia (2019) Emerg. Infect. Dis., 25, pp. 753-766; Bin, S.Y., Environmental contamination and viral shedding in MERS patients during MERS-CoV outbreak in South Korea (2016) Clin. Infect. Dis., 62, pp. 755-760; Prescott, J., Pathogenicity and viral shedding of MERS-CoV in immunocompromised rhesus macaques (2018) Front. Immunol., 9, p. 205; Dörnemann, J., First newborn baby to receive experimental therapies survives Ebola virus disease (2017) J. Infect. Dis., 215, pp. 171-174; Jacobs, M., Late Ebola virus relapse causing meningoencephalitis: A case report (2016) Lancet, 388, pp. 498-503; Mulangu, S., A randomized, controlled trial of Ebola virus disease therapeutics (2019) N. Engl. J. Med., 381, pp. 2293-2303; GS-5734 to Assess the Antiviral Activity, Long-Term Clearance of Ebola Virus and Safety in Male Ebola Survivors with Evidence of Ebola Virus Persistence in Semen, , https://clinicaltrials.gov/ct2/show/NCT02818582?term=NCT02818582&draw=2&rank=1, Accessed 25 January 2020; Investigational Therapeutics for the Treatment of People with Ebola Virus Disease, , https://clinicaltrials.gov/ct2/show/NCT03719586?term=remdesivir&rank=1, Accessed 25 January 2020; Novel Coronavirus (2019-nCoV), , https://www.who.int/emergencies/diseases/novel-coronavirus-2019, Accessed 25 January 2020; Falzarano, D., Infection with MERS-CoV causes lethal pneumonia in the common marmoset (2014) PLoS Pathog, 10; Brining, D.L., Thoracic radiography as a refinement methodology for the study of H1N1 influenza in cynomologus macaques (Macaca fascicularis) (2010) Comp. Med., 60, pp. 389-395; Corman, V.M., Detection of a novel human coronavirus by real-time reverse-transcription polymerase chain reaction (2012) Euro. Surveill., 17, p. 20285","de Wit, E.; Laboratory of Virology, National Institute of Allergy and Infectious Diseases, NIHUnited States; email: Emmie.deWit@nih.gov",,National Academy of Sciences,278424,,PNASA,32054787,English,Proc. Natl. Acad. Sci. U. S. A.,Article,Final,Open Access,Scopus,2-s2.0-85081590720,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Salisbury H.,56001030700;,Helen Salisbury: Coronavirus diaries,2020,The BMJ,368,, m1178,,,,,10.1136/bmj.m1178,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082380863&doi=10.1136%2fbmj.m1178&partnerID=40&md5=afdfb18cd877e821375f17067381f36f,"Oxford, United Kingdom","Salisbury, H., Oxford, United Kingdom",[No abstract available],,,,"Salisbury, H.; OxfordUnited Kingdom; email: helen.salisbury@phc.ox.ac.uk",,BMJ Publishing Group,9598146,,BMJOA,32209552,English,BMJ,Note,Final,Open Access,Scopus,2-s2.0-85082380863,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Livingston E., Bucher K., Rekito A.",7006243244;57192708609;8256107500;,Coronavirus Disease 2019 and Influenza 2019-2020,2020,JAMA,323,12,,1122,,,1,10.1001/jama.2020.2633,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082282318&doi=10.1001%2fjama.2020.2633&partnerID=40&md5=7b0db7012f1b5833dcb1471d645edc34,,"Livingston, E.; Bucher, K.; Rekito, A.",[No abstract available],,,,,,NLM (Medline),15383598,,,32207769,English,JAMA,Article,Final,Open Access,Scopus,2-s2.0-85082282318,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Swerdlow D.L., Finelli L.",7007016524;7007050800;,Preparation for Possible Sustained Transmission of 2019 Novel Coronavirus: Lessons From Previous Epidemics,2020,JAMA,323,12,,1129,1130,,3,10.1001/jama.2020.1960,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082007064&doi=10.1001%2fjama.2020.1960&partnerID=40&md5=36df7ae3ae20f7b847530dd083d597dd,"Pfizer Vaccines, CollegevillePA; Center for Observational and Real-World Evidence, Merck and Co Inc, Kenilworth, NJ","Swerdlow, D.L., Pfizer Vaccines, CollegevillePA; Finelli, L., Center for Observational and Real-World Evidence, Merck and Co Inc, Kenilworth, NJ",[No abstract available],,,,,,NLM (Medline),15383598,,,32207807,English,JAMA,Article,Final,Open Access,Scopus,2-s2.0-85082007064,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Qiang X.-L., Xu P., Fang G., Liu W.-B., Kou Z.",57215718145;57215923839;57215525735;57215924420;10640966700;,Using the spike protein feature to predict infection risk and monitor the evolutionary dynamic of coronavirus,2020,Infectious diseases of poverty,9,1,,33,,,,10.1186/s40249-020-00649-8,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082380781&doi=10.1186%2fs40249-020-00649-8&partnerID=40&md5=020c198101dd2376bf2a8449239c0356,"Institute of Computing Science and Technology, Guangzhou University, Guangzhou, 510006, China","Qiang, X.-L., Institute of Computing Science and Technology, Guangzhou University, Guangzhou, 510006, China; Xu, P., Institute of Computing Science and Technology, Guangzhou University, Guangzhou, 510006, China; Fang, G., Institute of Computing Science and Technology, Guangzhou University, Guangzhou, 510006, China; Liu, W.-B., Institute of Computing Science and Technology, Guangzhou University, Guangzhou, 510006, China; Kou, Z., Institute of Computing Science and Technology, Guangzhou University, Guangzhou, 510006, China","BACKGROUND: Coronavirus can cross the species barrier and infect humans with a severe respiratory syndrome. SARS-CoV-2 with potential origin of bat is still circulating in China. In this study, a prediction model is proposed to evaluate the infection risk of non-human-origin coronavirus for early warning. METHODS: The spike protein sequences of 2666 coronaviruses were collected from 2019 Novel Coronavirus Resource (2019nCoVR) Database of China National Genomics Data Center on Jan 29, 2020. A total of 507 human-origin viruses were regarded as positive samples, whereas 2159 non-human-origin viruses were regarded as negative. To capture the key information of the spike protein, three feature encoding algorithms (amino acid composition, AAC; parallel correlation-based pseudo-amino-acid composition, PC-PseAAC and G-gap dipeptide composition, GGAP) were used to train 41 random forest models. The optimal feature with the best performance was identified by the multidimensional scaling method, which was used to explore the pattern of human coronavirus. RESULTS: The 10-fold cross-validation results showed that well performance was achieved with the use of the GGAP (g = 3) feature. The predictive model achieved the maximum ACC of 98.18% coupled with the Matthews correlation coefficient (MCC) of 0.9638. Seven clusters for human coronaviruses (229E, NL63, OC43, HKU1, MERS-CoV, SARS-CoV, and SARS-CoV-2) were found. The cluster for SARS-CoV-2 was very close to that for SARS-CoV, which suggests that both of viruses have the same human receptor (angiotensin converting enzyme II). The big gap in the distance curve suggests that the origin of SARS-CoV-2 is not clear and further surveillance in the field should be made continuously. The smooth distance curve for SARS-CoV suggests that its close relatives still exist in nature and public health is challenged as usual. CONCLUSIONS: The optimal feature (GGAP, g = 3) performed well in terms of predicting infection risk and could be used to explore the evolutionary dynamic in a simple, fast and large-scale manner. The study may be beneficial for the surveillance of the genome mutation of coronavirus in the field.",Coronavirus; Cross-species infection; Machine learning; Spike protein,,,,,NLM (Medline),20499957,,,32209118,English,Infect Dis Poverty,Article,Final,Open Access,Scopus,2-s2.0-85082380781,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Jawhara S.,6503879479;,Could Intravenous Immunoglobulin Collected from Recovered Coronavirus Patients Protect against COVID-19 and Strengthen the Immune System of New Patients?,2020,International journal of molecular sciences,21,7,,,,,,10.3390/ijms21072272,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082561124&doi=10.3390%2fijms21072272&partnerID=40&md5=d260d38014f64def4133fdfff0c35ace,"CNRS, UMR 8576 - UGSF - Unité de Glycobiologie Structurale et Fonctionnelle, Lille, F-59000, France; University of Lille, Lille, F-59000, France","Jawhara, S., CNRS, UMR 8576 - UGSF - Unité de Glycobiologie Structurale et Fonctionnelle, Lille, F-59000, France, University of Lille, Lille, F-59000, France","The emergence of the novel coronavirus in Wuhan, China, which causes severe respiratory tract infections in humans (COVID-19), has become a global health concern. Most coronaviruses infect animals but can evolve into strains that cross the species barrier and infect humans. At the present, there is no single specific vaccine or efficient antiviral therapy against COVID-19. Recently, we showed that intravenous immunoglobulin (IVIg) treatment reduces inflammation of intestinal epithelial cells and eliminates overgrowth of the opportunistic human fungal pathogen Candida albicans in the murine gut. Immunotherapy with IVIg could be employed to neutralize COVID-19. However, the efficacy of IVIg would be better if the immune IgG antibodies were collected from patients who have recovered from COVID-19 in the same city, or the surrounding area, in order to increase the chance of neutralizing the virus. These immune IgG antibodies will be specific against COVID-19 by boosting the immune response in newly infected patients. Different procedures may be used to remove or inactivate any possible pathogens from the plasma of recovered coronavirus patient derived immune IgG, including solvent/detergent, 60 °C heat-treatment, and nanofiltration. Overall, immunotherapy with immune IgG antibodies combined with antiviral drugs may be an alternative treatment against COVID-19 until stronger options such as vaccines are available.",coronavirus; immunotherapy; IVIg; nCoV-2019; virus,,,,,NLM (Medline),14220067,,,32218340,English,Int J Mol Sci,Article,Final,Open Access,Scopus,2-s2.0-85082561124,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Ekins S., Lane T.R., Madrid P.B.",57203197233;57200699895;9841429500;,Tilorone: a Broad-Spectrum Antiviral Invented in the USA and Commercialized in Russia and beyond,2020,Pharmaceutical Research,37,4,71,,,,,10.1007/s11095-020-02799-8,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082495322&doi=10.1007%2fs11095-020-02799-8&partnerID=40&md5=5963b586acfbdcedfeeba101c6642ec6,"Collaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, Raleigh, NC27606, United States; SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, United States","Ekins, S., Collaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, Raleigh, NC27606, United States; Lane, T.R., Collaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, Raleigh, NC27606, United States; Madrid, P.B., SRI International, 333 Ravenswood Avenue, Menlo Park, CA 94025, United States","For the last 50 years we have known of a broad-spectrum agent tilorone dihydrochloride (Tilorone). This is a small-molecule orally bioavailable drug that was originally discovered in the USA and is currently used clinically as an antiviral in Russia and the Ukraine. Over the years there have been numerous clinical and non-clinical reports of its broad spectrum of antiviral activity. More recently we have identified additional promising antiviral activities against Middle East Respiratory Syndrome, Chikungunya, Ebola and Marburg which highlights that this old drug may have other uses against new viruses. This may in turn inform the types of drugs that we need for virus outbreaks such as for the new coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Tilorone has been long neglected by the west in many respects but it deserves further reassessment in light of current and future needs for broad-spectrum antivirals. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.",Antiviral; broad spectrum; interferon inducers; respiratory virus infections,,"Furuyama, W., Marzi, A., Ebola virus: pathogenesis and countermeasure development (2019) Annu Rev Virol, 6 (1), pp. 435-458; Musso, D., Ko, A.I., Baud, D., Zika virus infection - after the pandemic (2019) N Engl J Med, 381 (15), pp. 1444-1457; Wang, M., Cao, R., Zhang, L., Yang, X., Liu, J., Xu, M., Shi, Z., Xiao, G., Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro (2020) Cell Res; Holshue, M.L., Debolt, C., Lindquist, S., Lofy, K.H., Wiesman, J., Bruce, H., Spitters, C., Washington State -Nco, V.C.I.T., First Case of 2019 Novel Coronavirus in the United States (2020) N Engl J Med; https://www.cdc.gov/flu/about/burden/index.html, Influenza (flu); AIDS and HIV, , https://www.cdc.gov/nchs/fastats/aids-hiv.htm; https://www.cdc.gov/nchs/fastats/hepatitis.htm, CDC. Hepatitis B; Fleming, R.W., Wenstrup, D.L., Andrews, E.R., Bis-basic ethers and thioethers of fluorenone,fluorenol and fluorene, , US3592819A, editor.: Aventis Inc; 12/30/1968; Zhang, J., Yao, Q., Liu, Z., An effective synthesis method for Tilorone Dihydrochloride with obvious IFN-alpha inducing activity (2015) Molecules., 20 (12), pp. 21458-21463; Selkova, E.P., Iakovlev, V.N., Semenenko, T.A., Filatov, N.N., Gotvianskaia, T.P., Danilina, G.A., Pantiukhova, T.N., Tur'ianov, M., Evaluation of amyxin effect in prophylaxis of acute respiratory viral infections (2001) Zhurnal Mikrobiologii, Epidemiologii, I Immunobiologii., (3), pp. 42-46; https://rupharma.com/amixin/, Anon. Amixin; Krueger, R.E., Mayer, G.D., Tilorone hydrochloride: an orally active antiviral agent (1970) Science., 169 (3951), pp. 1213-1214; Katz, E., Margalith, E., Winer, B., The effect of tilorone hydrochloride on the growth of several animal viruses in tissue cultures (1976) The Journal of general virology, 31 (1), pp. 125-129; Katz, E., Margalith, E., Winer, B., Inhibition of herpesvirus deoxyribonucleic acid and protein synthesis by tilorone hydrochloride (1976) Antimicrob Agents Chemother, 9 (1), pp. 189-195; Veckenstedt, A., Witkowski, W., Hoffmann, S., Comparison of antiviral properties in mice of bis-pyrrolidinoacetamido-fluorenone (MLU-B75), bis-dipropylaminoacetamido-fluorenone (MLU-B76), and tilorone hydrochloride (1979) Acta Virol, 23 (2), pp. 153-158; Loginova, S., Koval'chuk, A.V., Borisevich, S.V., Syromiatnikova, S.I., Borisevich, G.V., Pashchenko Iu, I., Khamitov, R.A., Shuster, A.M., Antiviral activity of an interferon inducer amixin in experimental West Nile fever (2004) Vopr Virusol, 49 (2), pp. 8-11; Harrington, D.G., Lupton, H.W., Crabbs, C.L., Bolt, L.E., Cole, F.E., Hilmas, D.E., Adjuvant effects of tilorone hydrochloride (Analog 11,567) with inactivated Venezuelan equine encephalomyelitis virus vaccine (1981) Proceedings of the Society for Experimental Biology and Medicine Society for Experimental Biology and Medicine (New York, NY)., 166 (2), pp. 257-262; Shen, L., Niu, J., Wang, C., Huang, B., Wang, W., Zhu, N., Deng, Y., Tan, W., High-Throughput Screening and Identification of Potent Broad-Spectrum Inhibitors of Coronaviruses (2019) J Virol, (12), p. 93; Vargin, V.V., Zschiesche, W., Semenov, B.F., Effects of tilorone hydrochloride on experimental flavivirus infections in mice (1977) Acta Virol, 21 (2), pp. 114-118; Karpov, A.V., Zholobak, N.M., Spivak, N.Y., Rybalko, S.L., Antonenko, S.V., Krivokhatskaya, L.D., Virus-inhibitory effect of a yeast RNA-tilorone molecular complex in cell cultures (2001) Acta Virol, 45 (3), pp. 181-184; Kuehne, R.W., Pannier, W.L., Stephen, E.L., Evaluation of various analogues of tilorone hydrochloride against Venezuelan equine encephalitis virus in mice (1977) Antimicrob Agents Chemother, 11 (1), pp. 92-97; Kaufman, H.E., Centifanto, Y.M., Ellison, E.D., Brown, D.C., Tilorone hydrochloride: human toxicity and interferon stimulation (1971) Proc Soc Exp Biol Med, 137 (1), pp. 357-360; Semenenko, T.A., Selkova, E.P., Nikitina, G.Y., Gotvyanskaya, T.P., Yudina, T.I., Amaryan, M.P., Nosik, N.N., Turyanov, M.H., Immunomodulators in the prevention of acute respiratory viral infections (2002) Russ J Immunol, 7 (2), pp. 105-114; Selkova, E.P., Tur'ianov, M.C., Pantiukhova, T.N., Nikitina, G.I., Semenenko, T.A., Evaluation of amixine reactivity and efficacy for prophylaxis of acute respiratory tract infections (2001) Antibiot Khimioter, 46 (10), pp. 14-18; Sel'kova, E.P., Iakovlev, V.N., Semenenko, T.A., Filatov, N.N., Gotvianskaia, T.P., Danilina, G.A., Pantiukhova, T.N., Tur'ianov, M., Evaluation of amyxin effect in prophylaxis of acute respiratory viral infections (2001) Zh Mikrobiol Epidemiol Immunobiol, (3), pp. 42-46; Sel'kova, E.P., Semenenko, T.A., Nosik, N.N., Iudina, T.I., Amarian, M.P., Lavrukhina, L.A., Pantiukhova, T.N., Tarasova, G., Effect of amyxin--a domestic analog of tilorone--on characteristics of interferon and immune status of man (2001) Zh Mikrobiol Epidemiol Immunobiol, (4), pp. 31-35; Chizhov, N.P., Smol'skaia, T.T., Baichenko, P.I., Luk'ianova, R.I., Teslenko, V.M., Bavra, G.P., Romanchenko, I.A., Tazulakhova, E.B., Clinical research on the tolerance for and the interferon-inducing activity of amiksin (1990) Vopr Virusol, 35 (5), pp. 411-414; Zakirov, I.G., Use of amixin in the therapy and prevention of some viral infections (2002) Klin Med (Mosk), 80 (12), pp. 54-56; Madrid, P.B., Chopra, S., Manger, I.D., Gilfillan, L., Keepers, T.R., Shurtleff, A.C., Green, C.E., Tanga, M.J., A systematic screen of FDA-approved drugs for inhibitors of biological threat agents (2013) PLoS One, 8 (4); Madrid, P.B., Panchal, R.G., Warren, T.K., Shurtleff, A.C., Endsley, A.N., Green, C.E., Kolokoltsov, A., Tanga, M.J., Evaluation of Ebola virus inhibitors for drug repurposing (2015) ACS Infect Dis, 1 (7), pp. 317-326; Ekins, S., Freundlich, J.S., Clark, A.M., Anantpadma, M., Davey, R.A., Madrid, P., Machine learning models identify molecules active against the Ebola virus in vitro (2015) F1000Res, 4, p. 1091; Lane, T.R., Massey, C., Comer, J.E., Anantpadma, M., Freundlich, J.S., Davey, R.A., Madrid, P.B., Ekins, S., Repurposing the antimalarial pyronaridine tetraphosphate to protect against Ebola virus infection (2019) PLoS Negl Trop Dis, 13 (11); Lane, T.R., Massey, C., Comer, J.E., Freiberg, A.N., Zhou, H., Dyall, J., Holbrook, M.R., Ekins, S., (2020) Efficacy of Oral Pyronaridine Tetraphosphate and Favipiravir against Ebola Virus Infection in Guinea Pig Submitted; Ekins, S., Madrid, P.B., Tilorone: A broad-spectrum antiviral for emerging viruses Antimicrobial Agents Chemother, , https://doi.org/10.1101/2020.03.09.984856, In press. 2020 Preprint; Anantpadma, M., Lane, T., Zorn, K.M., Lingerfelt, M.A., Clark, A.M., Freundlich, J.S., Davey, R.A., Ekins, S., Ebola virus Bayesian machine learning models enable new in vitro leads (2019) ACS Omega, 4 (1), pp. 2353-2361; Ekins, S., Lingerfelt, M.A., Comer, J.E., Freiberg, A.N., Mirsalis, J.C., O'loughlin, K., Harutyunyan, A., Madrid, P.B., Efficacy of Tilorone Dihydrochloride against Ebola Virus Infection (2018) Antimicrob Agents Chemother, 62 (2); Mayer, G.D., Krueger, R.F., Tilorone hydrochloride: mode of action (1970) Science., 169 (3951), pp. 1214-1215; Ratan, R.R., Siddiq, A., Aminova, L., Langley, B., McConoughey, S., Karpisheva, K., Lee, H.H., Gazaryan, I., Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury (2008) Ann N Y Acad Sci, 1147, pp. 383-394; Gaforio, J.J., Ortega, E., Algarra, I., Serrano, M.J., Alvarez de Cienfuegos G. NK cells mediate increase of phagocytic activity but not of proinflammatory cytokine (interleukin-6 [IL-6], tumor necrosis factor alpha, and IL-12) production elicited in splenic macrophages by tilorone treatment of mice during acute systemic candidiasis (2002) Clin Diagn Lab Immunol, 9 (6), pp. 1282-1294; Liu, Q., Zhou, Y.H., Yang, Z.Q., The cytokine storm of severe influenza and development of immunomodulatory therapy (2016) Cell Mol Immunol, 13 (1), pp. 3-10; Kell, A.M., Gale, M., RIG-I in RNA virus recognition (2015) Virology, 479-480, pp. 110-121; Takeuchi, O., Akira, S., Pattern recognition receptors and inflammation (2010) Cell., 140 (6), pp. 805-820; Zholobak, N.M., Kavok, N.S., Bogorad-Kobelska, O.S., Borovoy, I.A., Malyukina, M.Y., Spivak MY. Effect of tilorone and its analogues on the change of mitochondrial potential of rat hepatocytes (2012) Fiziolohichnyi Zhurnal (Kiev, Ukraine: 1994), 58 (2), pp. 39-43; Dutta, M., Robertson, S.J., Okumura, A., Scott, D.P., Chang, J., Weiss, J.M., Sturdevant, G.L., Best, S.M., A systems approach reveals MAVS signaling in myeloid cells as critical for resistance to Ebola virus in murine models of infection (2017) Cell Rep, 18 (3), pp. 816-829; Martin, R.E., Marchetti, R.V., Cowan, A.I., Howitt, S.M., Broer, S., Kirk, K., Chloroquine transport via the malaria parasite's chloroquine resistance transporter (2009) Science., 325 (5948), pp. 1680-1682; Gupta, D.K., Gieselmann, V., Hasilik, A., von Figura, K., Tilorone acts as a lysosomotropic agent in fibroblasts (1984) Hoppe Seylers Z Physiol Chem, 365 (8), pp. 859-866; Lullmann-Rauch, R., Pods, R., Von Witzendorff, B., Tilorone-induced lysosomal storage of sulphated glycosaminoglycans can be separated from tilorone-induced enhancement of lysosomal enzyme secretion (1995) Biochem Pharmacol, 49 (9), pp. 1223-1233; Salata, C., Calistri, A., Parolin, C., Baritussio, A., Palu, G., Antiviral activity of cationic amphiphilic drugs (2017) Expert Rev Anti-Infect Ther, 15 (5), pp. 483-492; Garcia-Serradilla, M., Risco, C., Pacheco, B., Drug repurposing for new, efficient, broad spectrum antivirals (2019) Virus Res, 264, pp. 22-31; Andersen, P.I., Krpina, K., Ianevski, A., Shtaida, N., Jo, E., Yang, J., Koit, S., Kainov, D.E., Novel Antiviral Activities of Obatoclax, Emetine, Niclosamide, Brequinar, and Homoharringtonine (2019) Viruses, 11 (10); Mazzon, M., Ortega-Prieto, A.M., Imrie, D., Luft, C., Hess, L., Czieso, S., Grove, J., Marsh, M., Identification of Broad-Spectrum Antiviral Compounds by Targeting Viral Entry (2019) Viruses, 11 (2); Pecheur, E.I., Borisevich, V., Halfmann, P., Morrey, J.D., Smee, D.F., Prichard, M., Mire, C.E., Polyak, S.J., The synthetic antiviral drug Arbidol inhibits globally prevalent pathogenic viruses (2016) J Virol, 90 (6), pp. 3086-3092; Karpenko, I., Deev, S., Kiselev, O., Charushin, V., Rusinov, V., Ulomsky, E., Deeva, E., Kukhanova, M., Antiviral properties, metabolism, and pharmacokinetics of a novel azolo-1,2,4-triazine-derived inhibitor of influenza a and B virus replication (2010) Antimicrob Agents Chemother, 54 (5), pp. 2017-2022; Kramer, M.J., Cleeland, R., Grunberg, E., Antiviral activity of 10-carboxymethyl-9-acridanone (1976) Antimicrob Agents Chemother, 9 (2), pp. 233-238; Tazulakhova, E.B., Parshina, O.V., Guseva, T.S., Ershov, F.I., Russian experience in screening, analysis, and clinical application of novel interferon inducers (2001) J Interf Cytokine Res, 21 (2), pp. 65-73","Ekins, S.; Collaborations Pharmaceuticals, Inc., 840 Main Campus Drive, Lab 3510, United States; email: sean@collaborationspharma.com",,Springer,7248741,,PHREE,32215760,English,Pharm. Res.,Article,Final,Open Access,Scopus,2-s2.0-85082495322,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Hu X.H., Niu W.B., Zhang J.F., Li B.K., Yu B., Zhang Z.Y., Zhou C.X., Zhang X.N., Gao Y., Wang G.Y.",57209549089;57215840736;57194624061;57215844948;57201135975;55721920800;55771140400;57203328132;57188644986;56287694800;,Treatment strategies for colorectal cancer patients in tumor hospitals under the background of corona virus disease 2019,2020,Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery,23,3,,201,208,,,10.3760/cma.j.cn.441530-20200217-00058,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082033400&doi=10.3760%2fcma.j.cn.441530-20200217-00058&partnerID=40&md5=fdaba30b5bdc2014c4bfaf53b93e7df9,"Second Department of General Surgery, Fourth Hospital, Hebei Medical University, Shijiazhuang, 050000, China; Department of Surgery, Third Hospital, Hebei Medical University, Shijiazhuang, 050051, China","Hu, X.H., Second Department of General Surgery, Fourth Hospital, Hebei Medical University, Shijiazhuang, 050000, China; Niu, W.B., Second Department of General Surgery, Fourth Hospital, Hebei Medical University, Shijiazhuang, 050000, China; Zhang, J.F., Second Department of General Surgery, Fourth Hospital, Hebei Medical University, Shijiazhuang, 050000, China; Li, B.K., Second Department of General Surgery, Fourth Hospital, Hebei Medical University, Shijiazhuang, 050000, China; Yu, B., Second Department of General Surgery, Fourth Hospital, Hebei Medical University, Shijiazhuang, 050000, China; Zhang, Z.Y., Second Department of General Surgery, Fourth Hospital, Hebei Medical University, Shijiazhuang, 050000, China; Zhou, C.X., Second Department of General Surgery, Fourth Hospital, Hebei Medical University, Shijiazhuang, 050000, China; Zhang, X.N., Second Department of General Surgery, Fourth Hospital, Hebei Medical University, Shijiazhuang, 050000, China; Gao, Y., Second Department of General Surgery, Fourth Hospital, Hebei Medical University, Shijiazhuang, 050000, China; Wang, G.Y., Department of Surgery, Third Hospital, Hebei Medical University, Shijiazhuang, 050051, China","2019年12月,新型冠状病毒肺炎开始暴发流行,其病原体为2019-nCoV,具有感染力强,人群普遍易感的特点。目前新型冠状病毒肺炎的防控形势严峻。在这样的背景下,作为一线的医务工作者肩负着重要的责任和压力,但是通过我们严格的管理策略,可以尽可能地减少感染暴露的风险。笔者通过对近几年的研究进展和指南的归纳总结,从结直肠癌的疾病筛查、治疗策略(包括早期结直肠癌、局部晚期结直肠癌、梗阻性结直肠癌、转移性结直肠癌以及新辅助治疗后患者的治疗)、辅助治疗的药物选择和时限选择、急诊手术患者的防护措施、术后患者复查以及医务人员的防护等方面,进行了治疗策略的改进,以期在新型冠状病毒肺炎疫情严峻的形势下,为广大患者提供更多的选择,以获得最佳的治疗,也为各位同道提供更合时宜的治疗模式。.In December 2019, a new outbreak of corona virus disease 2019 began to occur. Its pathogen is 2019-nCoV, which has the characteristics of strong infectivity and general susceptibility. The current situation of prevention and control of new coronavirus pneumonia is severe. In this context, as front-line medical workers bearing important responsibilities and pressure, while through strict management strategy, we can minimize the risk of infection exposure. By summarizing the research progress and guidelines in recent years in the fields of colorectal cancer disease screening, treatment strategies (including early colorectal cancer, locally advanced colorectal cancer, obstructive colorectal cancer, metastatic colorectal cancer and the treatment of patients after neoadjuvant therapy), the choice of medication and time limit for adjuvant therapy, the protective measures for patients undergoing emergency surgery, the re-examination of postoperative patients and the protection of medical staff, etc., authors improve treatment strategies in order to provide more choices for patients to obtain the best treatment under the severe epidemic situation of new coronavirus pneumonia. Meanwhile we hope that it can also provide more timely treatment modeling schemes for colleagues.",2019-nCoV; Colorectal neoplasms; Corona virus disease 2019; Treatment strategy,"COVID-19; colorectal tumor; complication; Coronavirus infection; early cancer diagnosis; epidemic; human; virus pneumonia; Colorectal Neoplasms; Coronavirus Infections; Disease Outbreaks; Early Detection of Cancer; Humans; Pneumonia, Viral",,,,NLM (Medline),16710274,,,32192294,Chinese,Zhonghua Wei Chang Wai Ke Za Zhi,Article,Final,,Scopus,2-s2.0-85082033400,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Francesconi V., Cichero E., Schenone S., Naesens L., Tonelli M.",57200657007;23970379500;7003607321;7005160225;24578243300;,Synthesis and Biological Evaluation of Novel (thio)semicarbazone-Based Benzimidazoles as Antiviral Agents against Human Respiratory Viruses,2020,"Molecules (Basel, Switzerland)",25,7,,,,,,10.3390/molecules25071487,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082561375&doi=10.3390%2fmolecules25071487&partnerID=40&md5=67c28f5f52ba0bad4917c66ef3ee22db,"Dipartimento di Farmacia, Università di Genova, Viale Benedetto XV 3, Genova, 16132, Italy; Rega Institute for Medical Research, KU Leuven, Herestraat 49, Leuven, B-3000, Belgium","Francesconi, V., Dipartimento di Farmacia, Università di Genova, Viale Benedetto XV 3, Genova, 16132, Italy; Cichero, E., Dipartimento di Farmacia, Università di Genova, Viale Benedetto XV 3, Genova, 16132, Italy; Schenone, S., Dipartimento di Farmacia, Università di Genova, Viale Benedetto XV 3, Genova, 16132, Italy; Naesens, L., Rega Institute for Medical Research, KU Leuven, Herestraat 49, Leuven, B-3000, Belgium; Tonelli, M., Dipartimento di Farmacia, Università di Genova, Viale Benedetto XV 3, Genova, 16132, Italy","Respiratory RNA viruses are responsible for recurrent acute respiratory illnesses that still represent a major medical need. Previously we developed a large variety of benzimidazole derivatives able to inhibit these viruses. Herein, two series of (thio)semicarbazone- and hydrazone-based benzimidazoles have been explored, by derivatizing 5-acetyl benzimidazoles previously reported by us, thereby evaluating the influence of the modification on the antiviral activity. Compounds 6, 8, 16 and 17, bearing the 5-(thio)semicarbazone and 5-hydrazone functionalities in combination with the 2-benzyl ring on the benzimidazole core structure, acted as dual inhibitors of influenza A virus and human coronavirus. For respiratory syncytial virus (RSV), activity is limited to the 5-thiosemicarbazone (25) and 5-hydrazone (22) compounds carrying the 2-[(benzotriazol-1/2-yl)methyl]benzimidazole scaffold. These molecules proved to be the most effective antiviral agents, able to reach the potency profile of the licensed drug ribavirin. The molecular docking analysis explained the SAR of these compounds around their binding mode to the target RSV F protein, revealing the key contacts for further assessment. The herein-investigated benzimidazole-based derivatives may represent valuable hit compounds, deserving subsequent structural improvements towards more efficient antiviral agents for the treatment of pathologies caused by these human respiratory viruses.",(thio)semicarbazone-based benzimidazoles; anti-coronavirus activity; anti-influenza activity; anti-RSV activity; hydrazone-based benzimidazoles; molecular modelling studies,,,,,NLM (Medline),14203049,,,32218301,English,Molecules,Article,Final,Open Access,Scopus,2-s2.0-85082561375,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhang G., Zhang J., Wang B., Zhu X., Wang Q., Qiu S.",57216086282;57214900590;57216087855;57216087931;57216087179;57216086765;,"Analysis of clinical characteristics and laboratory findings of 95 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a retrospective analysis",2020,Respiratory research,21,1,,74,,,,10.1186/s12931-020-01338-8,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082562179&doi=10.1186%2fs12931-020-01338-8&partnerID=40&md5=ae678246db95bfd6165f6c4266191041,"Department of infectious disease, Wuhan Xinzhou District People's Hospital, Wuhan, China; Department of Neurology, Wuhan Xinzhou District People's Hospital, Hubei Province, 61 Xinzhou street, Wuhan, 430000, China; Department of critical care medicine, Wuhan Xinzhou District People's Hospital, Wuhan, China","Zhang, G., Department of infectious disease, Wuhan Xinzhou District People's Hospital, Wuhan, China; Zhang, J., Department of Neurology, Wuhan Xinzhou District People's Hospital, Hubei Province, 61 Xinzhou street, Wuhan, 430000, China; Wang, B., Department of infectious disease, Wuhan Xinzhou District People's Hospital, Wuhan, China; Zhu, X., Department of infectious disease, Wuhan Xinzhou District People's Hospital, Wuhan, China; Wang, Q., Department of infectious disease, Wuhan Xinzhou District People's Hospital, Wuhan, China; Qiu, S., Department of critical care medicine, Wuhan Xinzhou District People's Hospital, Wuhan, China","BACKGROUND: Since December 2019, 2019 novel coronavirus pneumonia emerged in Wuhan city and rapidly spread throughout China and even the world. We sought to analyse the clinical characteristics and laboratory findings of some cases with 2019 novel coronavirus pneumonia . METHODS: In this retrospective study, we extracted the data on 95 patients with laboratory-confirmed 2019 novel coronavirus pneumonia in Wuhan Xinzhou District People's Hospital from January 16th to February 25th, 2020. Cases were confirmed by real-time RT-PCR and abnormal radiologic findings. Outcomes were followed up until March 2th, 2020. RESULTS: Higher temperature, blood leukocyte count, neutrophil count, neutrophil percentage, C-reactive protein level, D-dimer level, alanine aminotransferase activity, aspartate aminotransferase activity, α - hydroxybutyrate dehydrogenase activity, lactate dehydrogenase activity and creatine kinase activity were related to severe 2019 novel coronavirus pneumonia and composite endpoint, and so were lower lymphocyte count, lymphocyte percentage and total protein level. Age below 40 or above 60 years old, male, higher Creatinine level, and lower platelet count also seemed related to severe 2019 novel coronavirus pneumonia and composite endpoint, however the P values were greater than 0.05, which mean under the same condition studies of larger samples are needed in the future. CONCLUSION: Multiple factors were related to severe 2019 novel coronavirus pneumonia and composite endpoint, and more related studies are needed in the future.",2019 novel coronavirus; Clinical characteristics; Laboratory findings; Pneumonia,,,,,NLM (Medline),1465993X,,,32216803,English,Respir. Res.,Article,Final,Open Access,Scopus,2-s2.0-85082562179,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Chen T., Wu D., Chen H., Yan W., Yang D., Chen G., Ma K., Xu D., Yu H., Wang H., Wang T., Guo W., Chen J., Ding C., Zhang X., Huang J., Han M., Li S., Luo X., Zhao J., Ning Q.",57216087322;57216086534;57216086000;57216087599;57216085935;57216087602;57216087845;57216087276;57216086348;57216087820;57216087262;56780800700;57216087141;57216087926;57203326931;57216087419;57216086648;9132965200;55725407400;57216087854;57209058566;,Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study,2020,BMJ (Clinical research ed.),368,,,m1091,,,,10.1136/bmj.m1091,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082561225&doi=10.1136%2fbmj.m1091&partnerID=40&md5=f0465cce7c93f17bc635cc67522ae9a8,"Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China; Department of Respiratory Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Emergency Medicine, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China; Department of Paediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","Chen, T., Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China; Wu, D., Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China; Chen, H., Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China; Yan, W., Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China; Yang, D., Department of Respiratory Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Chen, G., Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China; Ma, K., Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China; Xu, D., Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China; Yu, H., Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China; Wang, H., Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China; Wang, T., Department of Respiratory Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Guo, W., Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China; Chen, J., Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China; Ding, C., Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China; Zhang, X., Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China; Huang, J., Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China; Han, M., Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China; Li, S., Department of Emergency Medicine, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China; Luo, X., Department of Paediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Zhao, J., Department of Respiratory Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Ning, Q., Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China","OBJECTIVE: To delineate the clinical characteristics of patients with coronavirus disease 2019 (covid-19) who died. DESIGN: Retrospective case series. SETTING: Tongji Hospital in Wuhan, China. PARTICIPANTS: Among a cohort of 799 patients, 113 who died and 161 who recovered with a diagnosis of covid-19 were analysed. Data were collected until 28 February 2020. MAIN OUTCOME MEASURES: Clinical characteristics and laboratory findings were obtained from electronic medical records with data collection forms. RESULTS: The median age of deceased patients (68 years) was significantly older than recovered patients (51 years). Male sex was more predominant in deceased patients (83; 73%) than in recovered patients (88; 55%). Chronic hypertension and other cardiovascular comorbidities were more frequent among deceased patients (54 (48%) and 16 (14%)) than recovered patients (39 (24%) and 7 (4%)). Dyspnoea, chest tightness, and disorder of consciousness were more common in deceased patients (70 (62%), 55 (49%), and 25 (22%)) than in recovered patients (50 (31%), 48 (30%), and 1 (1%)). The median time from disease onset to death in deceased patients was 16 (interquartile range 12.0-20.0) days. Leukocytosis was present in 56 (50%) patients who died and 6 (4%) who recovered, and lymphopenia was present in 103 (91%) and 76 (47%) respectively. Concentrations of alanine aminotransferase, aspartate aminotransferase, creatinine, creatine kinase, lactate dehydrogenase, cardiac troponin I, N-terminal pro-brain natriuretic peptide, and D-dimer were markedly higher in deceased patients than in recovered patients. Common complications observed more frequently in deceased patients included acute respiratory distress syndrome (113; 100%), type I respiratory failure (18/35; 51%), sepsis (113; 100%), acute cardiac injury (72/94; 77%), heart failure (41/83; 49%), alkalosis (14/35; 40%), hyperkalaemia (42; 37%), acute kidney injury (28; 25%), and hypoxic encephalopathy (23; 20%). Patients with cardiovascular comorbidity were more likely to develop cardiac complications. Regardless of history of cardiovascular disease, acute cardiac injury and heart failure were more common in deceased patients. CONCLUSION: Severe acute respiratory syndrome coronavirus 2 infection can cause both pulmonary and systemic inflammation, leading to multi-organ dysfunction in patients at high risk. Acute respiratory distress syndrome and respiratory failure, sepsis, acute cardiac injury, and heart failure were the most common critical complications during exacerbation of covid-19. © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.",,,,,,NLM (Medline),17561833,,,32217556,English,BMJ,Article,Final,Open Access,Scopus,2-s2.0-85082561225,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Li Q., Guan X., Wu P., Wang X., Zhou L., Tong Y., Ren R., Leung K.S.M., Lau E.H.Y., Wong J.Y., Xing X., Xiang N., Wu Y., Li C., Chen Q., Li D., Liu T., Zhao J., Liu M., Tu W., Chen C., Jin L., Yang R., Wang Q., Zhou S., Wang R., Liu H., Luo Y., Liu Y., Shao G., Li H., Tao Z., Yang Y., Deng Z., Liu B., Ma Z., Zhang Y., Shi G., Lam T.T.Y., Wu J.T., Gao G.F., Cowling B.J., Yang B., Leung G.M., Feng Z.",57215929105;57215927288;57200942857;57215928883;57215929482;57215925709;56657186900;57194749530;7103086074;54390180800;57215928421;14007370600;57193089933;57215929070;57215929103;7405321443;57213151901;57215930356;57215926923;55767893900;57215929052;57215927400;57215928745;57215928300;57215926665;57215927152;57215927017;57215927435;57215927668;57215930005;57215925510;57215927211;57216113487;57215929466;57215926962;57215930246;36055553300;57215925882;57215926678;7409256423;57216110445;8644765500;57214464680;57215926735;57215926613;,"Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia",2020,The New England journal of medicine,382,13,,1199,1207,,189,10.1056/NEJMoa2001316,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082296756&doi=10.1056%2fNEJMoa2001316&partnerID=40&md5=f11682a57dc8594dcddb46332adbfd4c,"From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China","Li, Q., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Guan, X., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Wu, P., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Wang, X., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Zhou, L., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Tong, Y., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Ren, R., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Leung, K.S.M., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Lau, E.H.Y., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Wong, J.Y., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Xing, X., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Xiang, N., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Wu, Y., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Li, C., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Chen, Q., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Li, D., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Liu, T., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Zhao, J., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Liu, M., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Tu, W., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Chen, C., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu)",,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Jin, L., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Yang, R., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Wang, Q., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Zhou, S., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Wang, R., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Liu, H., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Luo, Y., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Liu, Y., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Shao, G., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Li, H., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Tao, Z., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Yang, Y., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Deng, Z., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Liu, B., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Ma, Z., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Zhang, Y., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Shi, G., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Lam, T.T.Y., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Wu, J.T., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Gao, G.F., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Cowling, B.J., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Yang, B., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Leung, G.M., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention, Shanghai (Z.M.) - all in China; Feng, Z., From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W., T.T.Y.L., J.T.W., B.J.C., G.M.L.), the Chinese Field Epidemiology Training Program, Chinese Center for Disease Control and Prevention, Beijing (T.L., R.Y., S.Z., H. Liu, Y. Liu, G. Shao, H. Li, Z.T.), the Jingzhou Center for Disease Control and Prevention, Jingzhou, Hubei (T.L.), the Chengdu Center for Disease Control and Prevention, Chengdu, Sichuan (H. Liu); the Hunan Provincial Center for Disease Control and Prevention, Changsha, Hunan (Y. Liu), the Anyang Municipal Center for Disease Control and Prevention, Anyang, Henan (G. Shao), the Panjin Center for Disease Control and Prevention, Panjin, Liaoning (H. Li), the Guizhou Center for Disease Control and Prevention, Guiyang, Guizhou (Z.T.), the Jiading District Center for Disease Control and Prevention, Shanghai (Y.Y.), the Nanchang Center for Disease Control and Prevention, Nanchang, Jiangxi (Z.D.), the Inner Mongolia Comprehensive Center for Disease Control and Prevention, Hohhot, Inner Mongolia (B.L.), and the Baoshan District Center for Disease Control and Prevention," Shanghai (Z.M.) - all in China""","BACKGROUND: The initial cases of novel coronavirus (2019-nCoV)-infected pneumonia (NCIP) occurred in Wuhan, Hubei Province, China, in December 2019 and January 2020. We analyzed data on the first 425 confirmed cases in Wuhan to determine the epidemiologic characteristics of NCIP. METHODS: We collected information on demographic characteristics, exposure history, and illness timelines of laboratory-confirmed cases of NCIP that had been reported by January 22, 2020. We described characteristics of the cases and estimated the key epidemiologic time-delay distributions. In the early period of exponential growth, we estimated the epidemic doubling time and the basic reproductive number. RESULTS: Among the first 425 patients with confirmed NCIP, the median age was 59 years and 56% were male. The majority of cases (55%) with onset before January 1, 2020, were linked to the Huanan Seafood Wholesale Market, as compared with 8.6% of the subsequent cases. The mean incubation period was 5.2 days (95% confidence interval [CI], 4.1 to 7.0), with the 95th percentile of the distribution at 12.5 days. In its early stages, the epidemic doubled in size every 7.4 days. With a mean serial interval of 7.5 days (95% CI, 5.3 to 19), the basic reproductive number was estimated to be 2.2 (95% CI, 1.4 to 3.9). CONCLUSIONS: On the basis of this information, there is evidence that human-to-human transmission has occurred among close contacts since the middle of December 2019. Considerable efforts to reduce transmission will be required to control outbreaks if similar dynamics apply elsewhere. Measures to prevent or reduce transmission should be implemented in populations at risk. (Funded by the Ministry of Science and Technology of China and others.). Copyright © 2020 Massachusetts Medical Society.",,,,,,NLM (Medline),15334406,,,31995857,English,N. Engl. J. Med.,Article,Final,Open Access,Scopus,2-s2.0-85082296756 CDC COVID-19 Response Team,,"Severe Outcomes Among Patients with Coronavirus Disease 2019 (COVID-19) - United States, February 12-March 16, 2020",2020,MMWR. Morbidity and mortality weekly report,69,12,,343,346,,1,10.15585/mmwr.mm6912e2,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082470762&doi=10.15585%2fmmwr.mm6912e2&partnerID=40&md5=48bd8387f0736e8f1e60e5ea2da169a5,,CDC COVID-19 Response Team,"Globally, approximately 170,000 confirmed cases of coronavirus disease 2019 (COVID-19) caused by the 2019 novel coronavirus (SARS-CoV-2) have been reported, including an estimated 7,000 deaths in approximately 150 countries (1). On March 11, 2020, the World Health Organization declared the COVID-19 outbreak a pandemic (2). Data from China have indicated that older adults, particularly those with serious underlying health conditions, are at higher risk for severe COVID-19-associated illness and death than are younger persons (3). Although the majority of reported COVID-19 cases in China were mild (81%), approximately 80% of deaths occurred among adults aged ≥60 years; only one (0.1%) death occurred in a person aged ≤19 years (3). In this report, COVID-19 cases in the United States that occurred during February 12-March 16, 2020 and severity of disease (hospitalization, admission to intensive care unit [ICU], and death) were analyzed by age group. As of March 16, a total of 4,226 COVID-19 cases in the United States had been reported to CDC, with multiple cases reported among older adults living in long-term care facilities (4). Overall, 31% of cases, 45% of hospitalizations, 53% of ICU admissions, and 80% of deaths associated with COVID-19 were among adults aged ≥65 years with the highest percentage of severe outcomes among persons aged ≥85 years. In contrast, no ICU admissions or deaths were reported among persons aged ≤19 years. Similar to reports from other countries, this finding suggests that the risk for serious disease and death from COVID-19 is higher in older age groups.",,"adolescent; adult; age distribution; aged; child; Coronavirus infection; epidemiology; human; infant; middle aged; mortality; newborn; preschool child; risk factor; severity of illness index; treatment outcome; United States; very elderly; virus pneumonia; young adult; Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Child; Child, Preschool; Coronavirus Infections; Humans; Infant; Infant, Newborn; Middle Aged; Pneumonia, Viral; Risk Factors; Severity of Illness Index; Treatment Outcome; United States; Young Adult",,,,NLM (Medline),1545861X,,,32214079,English,MMWR Morb. Mortal. Wkly. Rep.,Article,Final,Open Access,Scopus,2-s2.0-85082470762,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Yan R., Zhang Y., Li Y., Xia L., Guo Y., Zhou Q.",56365238600;57214916717;57215972788;57215971426;57215972509;56604483600;,Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2,2020,Science,367,6485,,1444,1448,,4,10.1126/science.abb2762,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082184064&doi=10.1126%2fscience.abb2762&partnerID=40&md5=b96c81ab12dedc4608dc19984b220f72,"Key Laboratory of Structural Biology of Zhejiang Province, Institute of Biology, Westlake Institute for Advanced Study, 18 Shilongshan Road, Hangzhou, Zhejiang Province, 310024, China; School of Life Sciences, Westlake University, 18 Shilongshan Road, Hangzhou, Zhejiang Province, 310024, China; Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, 100084, China","Yan, R., Key Laboratory of Structural Biology of Zhejiang Province, Institute of Biology, Westlake Institute for Advanced Study, 18 Shilongshan Road, Hangzhou, Zhejiang Province, 310024, China, School of Life Sciences, Westlake University, 18 Shilongshan Road, Hangzhou, Zhejiang Province, 310024, China; Zhang, Y., Key Laboratory of Structural Biology of Zhejiang Province, Institute of Biology, Westlake Institute for Advanced Study, 18 Shilongshan Road, Hangzhou, Zhejiang Province, 310024, China, School of Life Sciences, Westlake University, 18 Shilongshan Road, Hangzhou, Zhejiang Province, 310024, China; Li, Y., Beijing Advanced Innovation Center for Structural Biology, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, 100084, China; Xia, L., Key Laboratory of Structural Biology of Zhejiang Province, Institute of Biology, Westlake Institute for Advanced Study, 18 Shilongshan Road, Hangzhou, Zhejiang Province, 310024, China, School of Life Sciences, Westlake University, 18 Shilongshan Road, Hangzhou, Zhejiang Province, 310024, China; Guo, Y., Key Laboratory of Structural Biology of Zhejiang Province, Institute of Biology, Westlake Institute for Advanced Study, 18 Shilongshan Road, Hangzhou, Zhejiang Province, 310024, China, School of Life Sciences, Westlake University, 18 Shilongshan Road, Hangzhou, Zhejiang Province, 310024, China; Zhou, Q., Key Laboratory of Structural Biology of Zhejiang Province, Institute of Biology, Westlake Institute for Advanced Study, 18 Shilongshan Road, Hangzhou, Zhejiang Province, 310024, China, School of Life Sciences, Westlake University, 18 Shilongshan Road, Hangzhou, Zhejiang Province, 310024, China","Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for severe acute respiratory syndrome–coronavirus (SARS-CoV) and the new coronavirus (SARS-CoV-2) that is causing the serious coronavirus disease 2019 (COVID-19) epidemic. Here, we present cryo–electron microscopy structures of full-length human ACE2 in the presence of the neutral amino acid transporter B0AT1 with or without the receptor binding domain (RBD) of the surface spike glycoprotein (S protein) of SARS-CoV-2, both at an overall resolution of 2.9 angstroms, with a local resolution of 3.5 angstroms at the ACE2-RBD interface. The ACE2-B0AT1 complex is assembled as a dimer of heterodimers, with the collectrin-like domain of ACE2 mediating homodimerization. The RBD is recognized by the extracellular peptidase domain of ACE2 mainly through polar residues. These findings provide important insights into the molecular basis for coronavirus recognition and infection. © 2020 American Association for the Advancement of Science. All rights reserved.",,enzyme; gene; gene expression; protein; ultrastructure; virus; Coronavirus; SARS coronavirus,"Zhu, N., (2020) N. Engl. J. 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Hepatol., (20), pp. 30048-30050. , S2468-1253; Jando, J., Camargo, S.M.R., Herzog, B., Verrey, F., (2017) PLOS ONE, 12","Zhou, Q.; Key Laboratory of Structural Biology of Zhejiang Province, Institute of Biology, Westlake Institute for Advanced Study, 18 Shilongshan Road, China; email: zhouqiang@westlake.edu.cn",,American Association for the Advancement of Science,368075,,SCIEA,32132184,English,Sci.,Article,Final,Open Access,Scopus,2-s2.0-85082184064,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Huang L., Lin G., Tang L., Yu L., Zhou Z.",57216077833;57216077853;57216077901;57216077786;57216077784;,Special attention to nurses' protection during the COVID-19 epidemic,2020,Critical Care,24,1,120,,,,,10.1186/s13054-020-2841-7,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082542845&doi=10.1186%2fs13054-020-2841-7&partnerID=40&md5=eef21f26f71b85972581a2863f11fcab,"Spine Department, Orthopaedic Center, Guangdong Second Provincial General Hospital, Guang Zhou, Guangdong Province, China; Infection Control Department, Guangdong Second Provincial General Hospital, Guang Zhou, Guangdong Province, China; Nursing Department, Guangdong Second Provincial General Hospital, Guang Zhou, Guangdong Province, China","Huang, L., Spine Department, Orthopaedic Center, Guangdong Second Provincial General Hospital, Guang Zhou, Guangdong Province, China; Lin, G., Infection Control Department, Guangdong Second Provincial General Hospital, Guang Zhou, Guangdong Province, China; Tang, L., Nursing Department, Guangdong Second Provincial General Hospital, Guang Zhou, Guangdong Province, China; Yu, L., Nursing Department, Guangdong Second Provincial General Hospital, Guang Zhou, Guangdong Province, China; Zhou, Z., Spine Department, Orthopaedic Center, Guangdong Second Provincial General Hospital, Guang Zhou, Guangdong Province, China","As of March 8, 2020, the novel coronavirus disease 2019 (COVID-19) had caused 80,815 human infections and 3073 deaths in China, including more than 3000 infections among medical staff. Guangdong Second Provincial General Hospital (Guangzhou, Guangdong Province, China), a provincial emergency hospital, has treated more than 35 confirmed cases of COVID-19 and more than 260 suspected cases. Most of nurses' work involves direct contact with patients. As nurses have high vulnerability to COVID-19, it is necessary to establish hospital-specific protocols to reduce the risk of nurses' infection in interactions with COVID-19 patients. Our hospital has maintained a ""zero nurse infection"" rate while battling SARS in 2003 and during the present COVID-19 epidemic. The following are the key measures implemented in our hospital. © 2020 The Author(s). Reference:.",,,"Chen, X., Tian, J., Li, G., Li, G., Initiation of a new infection control system for the COVID-19 outbreak (2020) Lancet Infect Dis., , https://doi.org/10.1016/S1473-3099(20)30110-9, PMID: 32085850, [Epub ahead of print]","Zhou, Z.; Spine Department, Orthopaedic Center, Guangdong Second Provincial General HospitalChina; email: zhouzhilainba@163.com",,BioMed Central Ltd.,13648535,,CRCAF,32220243,English,Crit. Care,Review,Final,Open Access,Scopus,2-s2.0-85082542845,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Ou X., Liu Y., Lei X., Li P., Mi D., Ren L., Guo L., Guo R., Chen T., Hu J., Xiang Z., Mu Z., Chen X., Chen J., Hu K., Jin Q., Wang J., Qian Z.",56770753800;57211144231;57216038616;57202036412;57202038136;7202371986;57211790890;57211143455;57216038355;57216042131;57216041152;55844934700;57216036082;57216042703;57216041789;26030966000;56147682700;7201384775;,Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV,2020,Nature communications,11,1,,1620,,,,10.1038/s41467-020-15562-9,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082511797&doi=10.1038%2fs41467-020-15562-9&partnerID=40&md5=7ed64e5c303510c7a615303017c29eaa,"NHC Key laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100176, China; Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical Collage (PUMC), 151 Malianwa Road NorthBeijing 100193, China; Hengshui Third People's Hospital, China","Ou, X., NHC Key laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100176, China; Liu, Y., NHC Key laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100176, China; Lei, X., NHC Key laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100176, China; Li, P., NHC Key laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100176, China; Mi, D., NHC Key laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100176, China; Ren, L., NHC Key laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100176, China; Guo, L., NHC Key laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100176, China; Guo, R., NHC Key laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100176, China; Chen, T., NHC Key laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100176, China; Hu, J., NHC Key laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100176, China; Xiang, Z., NHC Key laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100176, China; Mu, Z., NHC Key laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100176, China; Chen, X., Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical Collage (PUMC), 151 Malianwa Road NorthBeijing 100193, China; Chen, J., Hengshui Third People's Hospital, China; Hu, K., Institute of Medicinal Plant Development (IMPLAD), Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical Collage (PUMC), 151 Malianwa Road NorthBeijing 100193, China; Jin, Q., NHC Key laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100176, China; Wang, J., NHC Key laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100176, China; Qian, Z., NHC Key laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100176, China","Since 2002, beta coronaviruses (CoV) have caused three zoonotic outbreaks, SARS-CoV in 2002-2003, MERS-CoV in 2012, and the newly emerged SARS-CoV-2 in late 2019. However, little is currently known about the biology of SARS-CoV-2. Here, using SARS-CoV-2 S protein pseudovirus system, we confirm that human angiotensin converting enzyme 2 (hACE2) is the receptor for SARS-CoV-2, find that SARS-CoV-2 enters 293/hACE2 cells mainly through endocytosis, that PIKfyve, TPC2, and cathepsin L are critical for entry, and that SARS-CoV-2 S protein is less stable than SARS-CoV S. Polyclonal anti-SARS S1 antibodies T62 inhibit entry of SARS-CoV S but not SARS-CoV-2 S pseudovirions. Further studies using recovered SARS and COVID-19 patients' sera show limited cross-neutralization, suggesting that recovery from one infection might not protect against the other. Our results present potential targets for development of drugs and vaccines for SARS-CoV-2.",,,,,,NLM (Medline),20411723,,,32221306,English,Nat Commun,Article,Final,Open Access,Scopus,2-s2.0-85082511797,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "McMichael T.M., Clark S., Pogosjans S., Kay M., Lewis J., Baer A., Kawakami V., Lukoff M.D., Ferro J., Brostrom-Smith C., Riedo F.X., Russell D., Hiatt B., Montgomery P., Rao A.K., Currie D.W., Chow E.J., Tobolowsky F., Bardossy A.C., Oakley L.P., Jacobs J.R., Schwartz N.G., Stone N., Reddy S.C., Jernigan J.A., Honein M.A., Clark T.A., Duchin J.S., Public Health - Seattle & King County, EvergreenHealth, and CDC COVID-19 Investigation Team",57215963846;57215970935;57200754141;56165933700;57215969068;7007112934;57188841956;57215962389;57215969260;57210572956;56299739800;57215967884;55336542600;57208655036;57215966894;57215967232;57215969891;57205474322;57191431717;57215971091;56640466900;57215863553;15849222700;57194536655;7005405217;55628579699;57215964961;6701392868;,"COVID-19 in a Long-Term Care Facility - King County, Washington, February 27-March 9, 2020",2020,MMWR. Morbidity and mortality weekly report,69,12,,339,342,,,10.15585/mmwr.mm6912e1,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082468601&doi=10.15585%2fmmwr.mm6912e1&partnerID=40&md5=cfd128b5394d64e4863bfb3fc978faed,,"McMichael, T.M.; Clark, S.; Pogosjans, S.; Kay, M.; Lewis, J.; Baer, A.; Kawakami, V.; Lukoff, M.D.; Ferro, J.; Brostrom-Smith, C.; Riedo, F.X.; Russell, D.; Hiatt, B.; Montgomery, P.; Rao, A.K.; Currie, D.W.; Chow, E.J.; Tobolowsky, F.; Bardossy, A.C.; Oakley, L.P.; Jacobs, J.R.; Schwartz, N.G.; Stone, N.; Reddy, S.C.; Jernigan, J.A.; Honein, M.A.; Clark, T.A.; Duchin, J.S.; Public Health - Seattle & King County, EvergreenHealth, and CDC COVID-19 Investigation Team","On February 28, 2020, a case of coronavirus disease (COVID-19) was identified in a woman resident of a long-term care skilled nursing facility (facility A) in King County, Washington.* Epidemiologic investigation of facility A identified 129 cases of COVID-19 associated with facility A, including 81 of the residents, 34 staff members, and 14 visitors; 23 persons died. Limitations in effective infection control and prevention and staff members working in multiple facilities contributed to intra- and interfacility spread. COVID-19 can spread rapidly in long-term residential care facilities, and persons with chronic underlying medical conditions are at greater risk for COVID-19-associated severe disease and death. Long-term care facilities should take proactive steps to protect the health of residents and preserve the health care workforce by identifying and excluding potentially infected staff members and visitors, ensuring early recognition of potentially infected patients, and implementing appropriate infection control measures.",,"adult; aged; case report; chronic disease; Coronavirus infection; epidemic; fatality; female; human; infection control; long term care; male; middle aged; mortality; nursing home; residential home; risk factor; very elderly; virus pneumonia; Washington; young adult; Adult; Aged; Aged, 80 and over; Chronic Disease; Coronavirus Infections; Disease Outbreaks; Fatal Outcome; Female; Humans; Infection Control; Long-Term Care; Male; Middle Aged; Pneumonia, Viral; Residential Facilities; Risk Factors; Skilled Nursing Facilities; Washington; Young Adult",,,,NLM (Medline),1545861X,,,32214083,English,MMWR Morb. Mortal. Wkly. Rep.,Article,Final,Open Access,Scopus,2-s2.0-85082468601,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Moriarty L.F., Plucinski M.M., Marston B.J., Kurbatova E.V., Knust B., Murray E.L., Pesik N., Rose D., Fitter D., Kobayashi M., Toda M., Canty P.T., Scheuer T., Halsey E.S., Cohen N.J., Stockman L., Wadford D.A., Medley A.M., Green G., Regan J.J., Tardivel K., White S., Brown C., Morales C., Yen C., Wittry B., Freeland A., Naramore S., Novak R.T., Daigle D., Weinberg M., Acosta A., Herzig C., Kapella B.K., Jacobson K.R., Lamba K., Ishizumi A., Sarisky J., Svendsen E., Blocher T., Wu C., Charles J., Wagner R., Stewart A., Mead P.S., Kurylo E., Campbell S., Murray R., Weidle P., Cetron M., Friedman C.R., CDC Cruise Ship Response Team, California Department of Public Health COVID-19 Team, Solano County COVID-19 Team",56465713900;57215969715;6603962165;57215967640;37031274300;55533152400;6603160546;55785730800;55504317400;55752102700;57208442260;57215967875;57215970373;57215965795;25959939100;57215965543;8563588800;57215269817;57215966426;55749700300;57190246498;57215965174;7408311862;57215972403;57215963993;57206781661;57215968726;56857544500;57215972615;57215962972;57215970710;57198200448;57215971235;13404108400;57215970523;56344281900;57215962915;6603237978;57215964644;57215966090;57215969479;57215966802;57215966300;57215962852;57215966836;55990638700;57215966482;57215970651;7004344959;56278989600;7203023569;,"Public Health Responses to COVID-19 Outbreaks on Cruise Ships - Worldwide, February-March 2020",2020,MMWR. Morbidity and mortality weekly report,69,12,,347,352,,,10.15585/mmwr.mm6912e3,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082445006&doi=10.15585%2fmmwr.mm6912e3&partnerID=40&md5=9bcd42a78c5e32bb181adb58ea9ca08d,,"Moriarty, L.F.; Plucinski, M.M.; Marston, B.J.; Kurbatova, E.V.; Knust, B.; Murray, E.L.; Pesik, N.; Rose, D.; Fitter, D.; Kobayashi, M.; Toda, M.; Canty, P.T.; Scheuer, T.; Halsey, E.S.; Cohen, N.J.; Stockman, L.; Wadford, D.A.; Medley, A.M.; Green, G.; Regan, J.J.; Tardivel, K.; White, S.; Brown, C.; Morales, C.; Yen, C.; Wittry, B.; Freeland, A.; Naramore, S.; Novak, R.T.; Daigle, D.; Weinberg, M.; Acosta, A.; Herzig, C.; Kapella, B.K.; Jacobson, K.R.; Lamba, K.; Ishizumi, A.; Sarisky, J.; Svendsen, E.; Blocher, T.; Wu, C.; Charles, J.; Wagner, R.; Stewart, A.; Mead, P.S.; Kurylo, E.; Campbell, S.; Murray, R.; Weidle, P.; Cetron, M.; Friedman, C.R.; CDC Cruise Ship Response Team; California Department of Public Health COVID-19 Team; Solano County COVID-19 Team","An estimated 30 million passengers are transported on 272 cruise ships worldwide each year* (1). Cruise ships bring diverse populations into proximity for many days, facilitating transmission of respiratory illness (2). SARS-CoV-2, the virus that causes coronavirus disease (COVID-19) was first identified in Wuhan, China, in December 2019 and has since spread worldwide to at least 187 countries and territories. Widespread COVID-19 transmission on cruise ships has been reported as well (3). Passengers on certain cruise ship voyages might be aged ≥65 years, which places them at greater risk for severe consequences of SARS-CoV-2 infection (4). During February-March 2020, COVID-19 outbreaks associated with three cruise ship voyages have caused more than 800 laboratory-confirmed cases among passengers and crew, including 10 deaths. Transmission occurred across multiple voyages of several ships. This report describes public health responses to COVID-19 outbreaks on these ships. COVID-19 on cruise ships poses a risk for rapid spread of disease, causing outbreaks in a vulnerable population, and aggressive efforts are required to contain spread. All persons should defer all cruise travel worldwide during the COVID-19 pandemic.",,"adult; aged; Betacoronavirus; Coronavirus infection; epidemic; female; global health; human; isolation and purification; male; middle aged; public health service; risk factor; ship; travel related disease; United States; virus pneumonia; Adult; Aged; Betacoronavirus; Coronavirus Infections; Disease Outbreaks; Female; Global Health; Humans; Male; Middle Aged; Pneumonia, Viral; Public Health Practice; Risk Factors; Ships; Travel-Related Illness; United States",,,,NLM (Medline),1545861X,,,32214086,English,MMWR Morb. Mortal. Wkly. Rep.,Article,Final,Open Access,Scopus,2-s2.0-85082445006,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Pung R., Chiew C.J., Young B.E., Chin S., Chen M.I.-C., Clapham H.E., Cook A.R., Maurer-Stroh S., Toh M.P.H.S., Poh C., Low M., Lum J., Koh V.T.J., Mak T.M., Cui L., Lin R.V.T.P., Heng D., Leo Y.-S., Lye D.C., Lee V.J.M., Kam K.-Q., Kalimuddin S., Tan S.Y., Loh J., Thoon K.C., Vasoo S., Khong W.X., Suhaimi N.-A., Chan S.J., Zhang E., Oh O., Ty A., Tow C., Chua Y.X., Chaw W.L., Ng Y., Abdul-Rahman F., Sahib S., Zhao Z., Tang C., Low C., Goh E.H., Lim G., Hou Y., Roshan I., Tan J., Foo K., Nandar K., Kurupatham L., Chan P.P., Raj P., Lin Y., Said Z., Lee A., See C., Markose J., Tan J., Chan G., See W., Peh X., Cai V., Chen W.K., Li Z., Soo R., Chow A.L., Wei W., Farwin A., Ang L.W., Singapore 2019 Novel Coronavirus Outbreak Research Team",57211477800;57216086172;50462822400;57209028620;57215938162;56180698600;57215269454;6602459149;23669334500;57215938032;57215935506;57215933032;57215932136;57215584812;57215788785;57215936380;57215863872;7004240142;14016391200;57216110803;57215932391;35484514100;57215585628;57214666030;35081338400;57214288354;42761499700;57215937281;57215937673;57193822153;57193821155;17347494300;36244540600;57215863776;57215863991;57208325803;57215937727;57215934556;57215863449;57215932484;57215934754;57191832534;57215935090;57215933786;57215938014;57215931703;57191624340;57194644563;57215584376;57215936268;57216058025;57215934098;57209028898;57215931776;57209023269;57215934422;57215931694;57215931887;57193820446;57215937245;57204418139;57215938050;57215864182;57215934781;57215933525;57215932551;57204759852;56569264500;,Investigation of three clusters of COVID-19 in Singapore: implications for surveillance and response measures,2020,The Lancet,395,10229,,1039,1046,,,10.1016/S0140-6736(20)30528-6,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082423866&doi=10.1016%2fS0140-6736%2820%2930528-6&partnerID=40&md5=81364a629a392d1516992fc43f350bf7,"Ministry of Health, Singapore; National Centre for Infectious Diseases, Singapore; Tan Tock Seng Hospital, Singapore; Saw Swee Hock School of Public Health, Singapore; National University of Singapore and National University Health System, Singapore; Bioinformatics Institute, Agency for Science, Technology and Research, Singapore; Department of Biological Sciences, National University of Singapore, Singapore; National Public Health Laboratory, National Centre for Infectious Diseases, Singapore; National Public Health and Epidemiology Unit, National Centre for Infectious Diseases, Singapore; Lee Kong Chian School of Medicine, Singapore; Yong Loo Lin School of Medicine, Singapore","Pung, R., Ministry of Health, Singapore; Chiew, C.J., Ministry of Health, Singapore; Young, B.E., National Centre for Infectious Diseases, Singapore, Tan Tock Seng Hospital, Singapore, Lee Kong Chian School of Medicine, Singapore; Chin, S., Ministry of Health, Singapore; Chen, M.I.-C., National Centre for Infectious Diseases, Singapore, Saw Swee Hock School of Public Health, Singapore; Clapham, H.E., Saw Swee Hock School of Public Health, Singapore, National University of Singapore and National University Health System, Singapore; Cook, A.R., Saw Swee Hock School of Public Health, Singapore, National University of Singapore and National University Health System, Singapore; Maurer-Stroh, S., Bioinformatics Institute, Agency for Science, Technology and Research, Singapore, Department of Biological Sciences, National University of Singapore, Singapore, National Public Health Laboratory, National Centre for Infectious Diseases, Singapore; Toh, M.P.H.S., National Public Health and Epidemiology Unit, National Centre for Infectious Diseases, Singapore; Poh, C., Ministry of Health, Singapore; Low, M., Ministry of Health, Singapore; Lum, J., Ministry of Health, Singapore; Koh, V.T.J., Ministry of Health, Singapore; Mak, T.M., National Public Health Laboratory, National Centre for Infectious Diseases, Singapore; Cui, L., National Public Health Laboratory, National Centre for Infectious Diseases, Singapore; Lin, R.V.T.P., National Public Health Laboratory, National Centre for Infectious Diseases, Singapore; Heng, D., Ministry of Health, Singapore; Leo, Y.-S., National Centre for Infectious Diseases, Singapore, Tan Tock Seng Hospital, Singapore, Saw Swee Hock School of Public Health, Singapore, Lee Kong Chian School of Medicine, Singapore, Yong Loo Lin School of Medicine, Singapore; Lye, D.C., National Centre for Infectious Diseases, Singapore, Tan Tock Seng Hospital, Singapore, Lee Kong Chian School of Medicine, Singapore, Yong Loo Lin School of Medicine, Singapore; Lee, V.J.M., Ministry of Health, Singapore, Saw Swee Hock School of Public Health, Singapore; Kam, K.-Q.; Kalimuddin, S.; Tan, S.Y.; Loh, J.; Thoon, K.C.; Vasoo, S.; Khong, W.X.; Suhaimi, N.-A.; Chan, S.J.; Zhang, E.; Oh, O.; Ty, A.; Tow, C.; Chua, Y.X.; Chaw, W.L.; Ng, Y.; Abdul-Rahman, F.; Sahib, S.; Zhao, Z.; Tang, C.; Low, C.; Goh, E.H.; Lim, G.; Hou, Y.; Roshan, I.; Tan, J.; Foo, K.; Nandar, K.; Kurupatham, L.; Chan, P.P.; Raj, P.; Lin, Y.; Said, Z.; Lee, A.; See, C.; Markose, J.; Tan, J.; Chan, G.; See, W.; Peh, X.; Cai, V.; Chen, W.K.; Li, Z.; Soo, R.; Chow, A.L.; Wei, W.; Farwin, A.; Ang, L.W.; Singapore 2019 Novel Coronavirus Outbreak Research Team","Background: Three clusters of coronavirus disease 2019 (COVID-19) linked to a tour group from China, a company conference, and a church were identified in Singapore in February, 2020. Methods: We gathered epidemiological and clinical data from individuals with confirmed COVID-19, via interviews and inpatient medical records, and we did field investigations to assess interactions and possible modes of transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Open source reports were obtained for overseas cases. We reported the median (IQR) incubation period of SARS-CoV-2. Findings: As of Feb 15, 2020, 36 cases of COVID-19 were linked epidemiologically to the first three clusters of circumscribed local transmission in Singapore. 425 close contacts were quarantined. Direct or prolonged close contact was reported among affected individuals, although indirect transmission (eg, via fomites and shared food) could not be excluded. The median incubation period of SARS-CoV-2 was 4 days (IQR 3–6). The serial interval between transmission pairs ranged between 3 days and 8 days. Interpretation: SARS-CoV-2 is transmissible in community settings, and local clusters of COVID-19 are expected in countries with high travel volume from China before the lockdown of Wuhan and institution of travel restrictions. Enhanced surveillance and contact tracing is essential to minimise the risk of widespread transmission in the community. Funding: None. © 2020 Elsevier Ltd",,lopinavir plus ritonavir; adult; aged; Article; clinical article; communicable disease control; coronavirus disease 2019; coronavirus disease 2019; Coronavirus infection; coughing; diarrhea; disease surveillance; dyspnea; female; fever; gene sequence; hospital admission; hospitalization; human; incubation time; infant; lymphocytopenia; male; middle aged; myalgia; nausea; phylogeny; polymerase chain reaction; priority journal; quarantine; rhinorrhea; SARS coronavirus; severe acute respiratory syndrome coronavirus 2; Singapore; sore throat; thorax pain; thorax radiography; thrombocytopenia; travel; virus transmission; vomiting,"Report on current pneumonia epidemic situation in the city. (In Chinese.) (2019), http://wjw.wuhan.gov.cn/front/web/showDetail/2019123108989, (Accessed 29 February 2020); Wuhan novel coronavirus prevention and control command notice (no 1). (In Chinese.) (2020), http://www.gov.cn/xinwen/2020-01/23/content_5471751.htm, (Accessed 29 February 2020); DW.com. Wuhan pneumonia virus continues to spread, Hubei orders 15 cities to be closed. (In Chinese.) (2020), https://www.dw.com/zh/a-52132769, (Accessed 29 February 2020); Statement on the second meeting of the International Health Regulations (2005) Emergency Committee regarding the outbreak of novel coronavirus (2019-nCoV) (2020), https://www.who.int/news-room/detail/30-01-2020-statement-on-the-second-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-outbreak-of-novel-coronavirus-(2019-ncov), (Accessed 29 February 2020); Coronavirus disease 2019 (COVID-2019): situation report—33 (2020), https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200222-sitrep-33-covid-19.pdf, (Accessed 29 February 2020); Confirmed imported case of novel coronavirus infection in Singapore; multi-ministry taskforce ramps up precautionary measures (2020), https://www.moh.gov.sg/news-highlights/details/confirmed-imported-case-of-novel-coronavirus-infection-in-singapore-multi-ministry-taskforce-ramps-up-precautionary-measures, (Accessed 29 February 2020); Infectious Diseases Act, chapter 137 (2003), https://sso.agc.gov.sg/Act/IDA1976, (accessed Feb 29, 2020); Emergency notice to find contacts of confirmed cases. (In Chinese.) (2020), http://m.gxzf.gov.cn/gxyw/20200203-793378.shtml, (Accessed 29 February 2020); 8 confirmed cases in Yulin City are in stable condition. (In Chinese.) (2020), http://m.gxylnews.com/html/news/2020/02/189458.html, (Accessed 29 February 2020); 2 new cases of pneumonia confirmed by new coronavirus infection in Yulin, a total of 7 cases. (In Chinese) (2020), https://v.gxnews.com.cn/a/19225623, (Accessed 29 February 2020); About the church. (In Chinese) http://www.lifechurchmissions.com/ChurchHistory.aspx, (Accessed 29 February 2020); Chan, J.F.-W., Yuan, S., Kok, K.-H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, 395, pp. 514-523; Novel coronavirus (2019-nCoV): situation report—3 (2020), https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200123-sitrep-3-2019-ncov.pdf, (Accessed 29 February 2020); 3 new coronavirus cases in South Korea; 2 men had travelled to Singapore for conference (2020), https://www.channelnewsasia.com/news/asia/wuhan-virus-coronavirus-south-korea-cases-12394934, (Accessed 29 February 2020); Ong, S.W.X., Tan, Y.K., Chia, P.Y., Air, surface environmental, and personal protective equipment contamination by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from a symptomatic patient (2020) JAMA, , published online March 4; Backer, J.A., Klinkenberg, D., Wallinga, J., Incubation period of 2019 novel coronavirus (2019-nCoV) infections among travellers from Wuhan, China, 20–28 January 2020 (2020) Euro Surveill, 25, p. 2000062; Lauer, S.A., Grantz, K.H., Bi, Q., The incubation period of 2019-nCoV from publicly reported confirmed cases: estimation and application (2020), https://www.medrxiv.org/content/10.1101/2020.02.02.20020016v1, (Accessed 29 February 2020)","Lee, V.J.M.; Communicable Diseases Division, Ministry of HealthSingapore; email: vernon_lee@moh.gov.sg",,Lancet Publishing Group,1406736,,LANCA,32192580,English,Lancet,Article,Final,,Scopus,2-s2.0-85082423866,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Memish Z.A., Perlman S., Van Kerkhove M.D., Zumla A.",7005059350;57204567845;15761388700;7006170723;,Middle East respiratory syndrome,2020,The Lancet,395,10229,,1063,1077,,1,10.1016/S0140-6736(19)33221-0,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082185623&doi=10.1016%2fS0140-6736%2819%2933221-0&partnerID=40&md5=ac4be5b274781663b60c32171dcdd9fc,"College of Medicine, Alfaisal University, Riyadh, Saudi Arabia; Research Center, King Saud Medical City Ministry of Health, Riyadh, Saudi Arabia; Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, United States; Department of Microbiology and Immunology, and Department of Pediatrics, University of Iowa, Iowa City, IA, United States; Infectious Hazards Management, Health Emergencies Programme, World Health Organization, Geneva, Switzerland; Department of Infection, Division of Infection and Immunity, Centre for Clinical Microbiology, University College London, London, United Kingdom; National Institute for Health Research Biomedical Research Centre, University College London Hospitals, London, United Kingdom","Memish, Z.A., College of Medicine, Alfaisal University, Riyadh, Saudi Arabia, Research Center, King Saud Medical City Ministry of Health, Riyadh, Saudi Arabia, Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, United States; Perlman, S., Department of Microbiology and Immunology, and Department of Pediatrics, University of Iowa, Iowa City, IA, United States; Van Kerkhove, M.D., Infectious Hazards Management, Health Emergencies Programme, World Health Organization, Geneva, Switzerland; Zumla, A., Department of Infection, Division of Infection and Immunity, Centre for Clinical Microbiology, University College London, London, United Kingdom, National Institute for Health Research Biomedical Research Centre, University College London Hospitals, London, United Kingdom","The Middle East respiratory syndrome coronavirus (MERS-CoV) is a lethal zoonotic pathogen that was first identified in humans in Saudi Arabia and Jordan in 2012. Intermittent sporadic cases, community clusters, and nosocomial outbreaks of MERS-CoV continue to occur. Between April 2012 and December 2019, 2499 laboratory-confirmed cases of MERS-CoV infection, including 858 deaths (34·3% mortality) were reported from 27 countries to WHO, the majority of which were reported by Saudi Arabia (2106 cases, 780 deaths). Large outbreaks of human-to-human transmission have occurred, the largest in Riyadh and Jeddah in 2014 and in South Korea in 2015. MERS-CoV remains a high-threat pathogen identified by WHO as a priority pathogen because it causes severe disease that has a high mortality rate, epidemic potential, and no medical countermeasures. 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Taylor, R., Kotian, P., Warren, T., BCX4430—a broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease (2016) J Infect Public Health, 9, pp. 220-226","Zumla, A.; Department of Infection, Division of Infection and Immunity, Centre for Clinical Microbiology, University College LondonUnited Kingdom; email: a.zumla@ucl.ac.uk",,Lancet Publishing Group,1406736,,LANCA,32145185,English,Lancet,Review,Final,Open Access,Scopus,2-s2.0-85082185623,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Kandel N., Chungong S., Omaar A., Xing J.",55654958400;6508191764;57190251587;36700727100;,Health security capacities in the context of COVID-19 outbreak: an analysis of International Health Regulations annual report data from 182 countries,2020,The Lancet,395,10229,,1047,1053,,1,10.1016/S0140-6736(20)30553-5,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082199073&doi=10.1016%2fS0140-6736%2820%2930553-5&partnerID=40&md5=a8f48b7ba5153a7947079e1e052a12ca,"World Health Organisation, WHO Health Emergency Program, Geneva, Switzerland","Kandel, N., World Health Organisation, WHO Health Emergency Program, Geneva, Switzerland; Chungong, S., World Health Organisation, WHO Health Emergency Program, Geneva, Switzerland; Omaar, A., World Health Organisation, WHO Health Emergency Program, Geneva, Switzerland; Xing, J., World Health Organisation, WHO Health Emergency Program, Geneva, Switzerland","Background: Public health measures to prevent, detect, and respond to events are essential to control public health risks, including infectious disease outbreaks, as highlighted in the International Health Regulations (IHR). In light of the outbreak of 2019 novel coronavirus disease (COVID-19), we aimed to review existing health security capacities against public health risks and events. Methods: We used 18 indicators from the IHR State Party Annual Reporting (SPAR) tool and associated data from national SPAR reports to develop five indices: (1) prevent, (2) detect, (3) respond, (4) enabling function, and (5) operational readiness. We used SPAR 2018 data for all of the indicators and categorised countries into five levels across the indices, in which level 1 indicated the lowest level of national capacity and level 5 the highest. We also analysed data at the regional level (using the six geographical WHO regions). Findings: Of 182 countries, 52 (28%) had prevent capacities at levels 1 or 2, and 60 (33%) had response capacities at levels 1 or 2. 81 (45%) countries had prevent capacities and 78 (43%) had response capacities at levels 4 or 5, indicating that these countries were operationally ready. 138 (76%) countries scored more highly in the detect index than in the other indices. 44 (24%) countries did not have an effective enabling function for public health risks and events, including infectious disease outbreaks (7 [4%] at level 1 and 37 [20%] at level 2). 102 (56%) countries had level 4 or level 5 enabling function capacities in place. 32 (18%) countries had low readiness (2 [1%] at level 1 and 30 [17%] at level 2), and 104 (57%) countries were operationally ready to prevent, detect, and control an outbreak of a novel infectious disease (66 [36%] at level 4 and 38 [21%] at level 5). Interpretation: Countries vary widely in terms of their capacity to prevent, detect, and respond to outbreaks. Half of all countries analysed have strong operational readiness capacities in place, which suggests that an effective response to potential health emergencies could be enabled, including to COVID-19. Findings from local risk assessments are needed to fully understand national readiness capacities in relation to COVID-19. Capacity building and collaboration between countries are needed to strengthen global readiness for outbreak control. Funding: None. © 2020 World Health Organization. Published by Elsevier Ltd. All rights reserved.",,Article; coronavirus disease 2019; Coronavirus infection; disease surveillance; emergency health service; global health; health care access; health care financing; health care system; health hazard; health security capacity; human; infection; infection control; infection prevention; international health regulation; pandemic; priority journal; public reporting (health care); World Health Organization,"Richman, D.D., Whitley, R.J., Hayden, F.G., (2016) Clinical virology, , 4th edn. 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Tokyo: World Health Organization, Dec 13, 2017 www.who.int/news-room/detail/13-12-2017-world-bank-and-who-half-the-world-lacks-access-to-essential-health-services-100-million-still-pushed-into-extreme-poverty-because-of-health-expenses, (Accessed 5 February 2020)","Kandel, N.; World Health Organisation, WHO Health Emergency ProgramSwitzerland; email: kandeln@who.int",,Lancet Publishing Group,1406736,,LANCA,32199075,English,Lancet,Article,Final,Open Access,Scopus,2-s2.0-85082199073,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Jiang Y., Cheng X., Zhao X., Yu Y., Gao M., Zhou S.",56078974300;57215111673;57212618796;57211996715;57214868742;38863664200;,Recombinant infectious bronchitis coronavirus H120 with the spike protein S1 gene of the nephropathogenic IBYZ strain remains attenuated but induces protective immunity,2020,Vaccine,38,15,,3157,3168,,,10.1016/j.vaccine.2020.01.001,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079144630&doi=10.1016%2fj.vaccine.2020.01.001&partnerID=40&md5=4503d83f82db4774a530560ae3d7ce7a,"Poultry Institute, Chinese Academy of Agricultural Sciences, Yangzhou, Jiangsu 225125, China","Jiang, Y., Poultry Institute, Chinese Academy of Agricultural Sciences, Yangzhou, Jiangsu 225125, China; Cheng, X., Poultry Institute, Chinese Academy of Agricultural Sciences, Yangzhou, Jiangsu 225125, China; Zhao, X., Poultry Institute, Chinese Academy of Agricultural Sciences, Yangzhou, Jiangsu 225125, China; Yu, Y., Poultry Institute, Chinese Academy of Agricultural Sciences, Yangzhou, Jiangsu 225125, China; Gao, M., Poultry Institute, Chinese Academy of Agricultural Sciences, Yangzhou, Jiangsu 225125, China; Zhou, S., Poultry Institute, Chinese Academy of Agricultural Sciences, Yangzhou, Jiangsu 225125, China","Infectious bronchitis (IB) is a highly infectious viral disease responsible for major economic losses in the poultry industry. A reverse genetic vaccine is a safe, rapid, and effective method of achieving IB prevention and control. In this study, we constructed the recombinant strain, rH120-S1/YZ, using a reverse genetic system, based on the backbone of the H120 vaccine strain, with the S1 gene replaced with that of the QX-like nephropathogenic strain, ck/CH/IBYZ/2011, isolated in China. The results of dwarf chicken embryos, growth kinetics, and viral titration in the embryos demonstrated that the biological characteristics of the recombinant virus remained unchanged. Like the rH120-infected group and in contrast to the rIBYZ-infected group, no mortality, clinical signs, or lesions were observed in the lungs or kidneys of young chickens inoculated with rH120-S1/YZ. The viral loads in various tissues, cloacal, and oral swabs was lower in most types of samples, indicating that the rH120-S1/YZ strain was highly safe in chicks. Compared to rH120 vaccination group, when the efficacy of this strain was evaluated against the QX-like IBV strain, better protection, with 100% survival rate and no disease symptom or gross lesion was observed in the chickens vaccinated with rH120-S1/YZ. Increased levels of IBV-specific antibodies were detected in the serum of the rH120-S1/YZ-vaccinated animals 14 days post-vaccination. 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Dhinakar Raj, G., Jones, R.C., Protectotypic differentiation of avian infectious bronchitis viruses using an in vitro challenge model (1996) Vet Microbiol, 53, pp. 239-252; Kotani, T., Wada, S., Tsukamoto, Y., Kuwamura, M., Yamate, J., Sakuma, S., Kinetics of lymphocytic subsets in chicken tracheal lesions infected with infectious bronchitis virus (2000) J Vet Med Sci, 62, pp. 397-401; Collisson, E.W., Pei, J., Dzielawa, J., Seo, S.H., Cytotoxic T lymphocytes are critical in the control of infectious bronchitis virus in poultry (2000) Dev Comp Immunol, 24, pp. 187-200; Kusters, J.G., Jager, E.J., Lenstra, J.A., Koch, G., Posthumus, W.P., Meloen, R.H., Analysis of an immunodominant region of infectious bronchitis virus (1989) J Immunol, 143, pp. 2692-2698; Ignjatovic, J., Sapats, S., Identification of previously unknown antigenic epitopes on the S and N proteins of avian infectious bronchitis virus (2005) Arch Virol, 150, pp. 1813-1831","Zhou, S.; Poultry Institute, Chinese Academy of Agricultural Sciences, 58 Cangjie Road, China; email: yixuanjiang@126.com",,Elsevier Ltd,0264410X,,VACCD,32057575,English,Vaccine,Article,Final,Open Access,Scopus,2-s2.0-85079144630,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Kooraki S., Hosseiny M., Myers L., Gholamrezanezhad A.",40461597200;57193858612;57215919111;10044363200;,Coronavirus (COVID-19) Outbreak: What the Department of Radiology Should Know,2020,Journal of the American College of Radiology,17,4,,447,451,,,10.1016/j.jacr.2020.02.008,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082304917&doi=10.1016%2fj.jacr.2020.02.008&partnerID=40&md5=4070c43ced006fb7c081a153a802e47d,"Keck School of Medicine, University of Southern California, Los Angeles, CA, United States; Department of Radiological Sciences, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, United States; Division of Emergency Radiology, Department of Radiology, Keck School of Medicine, University of Sothern California, Los Angeles, CA, United States","Kooraki, S., Keck School of Medicine, University of Southern California, Los Angeles, CA, United States; Hosseiny, M., Department of Radiological Sciences, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, United States; Myers, L., Division of Emergency Radiology, Department of Radiology, Keck School of Medicine, University of Sothern California, Los Angeles, CA, United States; Gholamrezanezhad, A., Division of Emergency Radiology, Department of Radiology, Keck School of Medicine, University of Sothern California, Los Angeles, CA, United States","In December 2019, a novel coronavirus (COVID-19) pneumonia emerged in Wuhan, China. Since then, this highly contagious COVID-19 has been spreading worldwide, with a rapid rise in the number of deaths. Novel COVID-19–infected pneumonia (NCIP) is characterized by fever, fatigue, dry cough, and dyspnea. A variety of chest imaging features have been reported, similar to those found in other types of coronavirus syndromes. The purpose of the present review is to briefly discuss the known epidemiology and the imaging findings of coronavirus syndromes, with a focus on the reported imaging findings of NCIP. Moreover, the authors review precautions and safety measures for radiology department personnel to manage patients with known or suspected NCIP. Implementation of a robust plan in the radiology department is required to prevent further transmission of the virus to patients and department staff members. © 2020 American College of Radiology",Coronavirus; COVID-19; infection control; pneumonia; safety,Article; Coronavirus disease 2019; Coronavirus infection; diagnostic imaging; epidemic; Middle East respiratory syndrome; pneumonia; radiology department; severe acute respiratory syndrome,"Weiss, S.R., Leibowitz, J.L., Coronavirus pathogenesis (2011) Adv Virus Res, 81, pp. 85-164; Wang, C., Horby, P.W., Hayden, F.G., Gao, G.F., A novel coronavirus outbreak of global health concern (2020) Lancet, 395, pp. 470-473; Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China 2019 (2020) N Engl J Med, 382, pp. 727-733; Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N Engl J Med. In press. DOI:; Rothe, C., Schunk, M., Sothmann, P., Transmission of 2019-nCoV infection from an asymptomatic contact in Germany (2020) N Engl J Med, 382, pp. 970-971; Chan-Yeung, M., Xu, R.H., SARS: epidemiology (2003) Respirology, 8, pp. S9-S14; Sampathkumar, P., Temesgen, Z., Smith, T.F., Thompson, R.L., SARS: epidemiology, clinical presentation, management, and infection control measures (2003) Mayo Clin Proc, 78, pp. 882-890; Paul, N.S., Roberts, H., Butany, J., Radiologic pattern of disease in patients with severe acute respiratory syndrome: the Toronto experience (2004) Radiographics, 24, pp. 553-563; Wong, K.T., Antonio, G.E., Hui, D.S., Severe acute respiratory syndrome: radiographic appearances and pattern of progression in 138 patients (2003) Radiology, 228, pp. 401-406; Zaki, A.M., van Boheemen, S., Bestebroer, T.M., Osterhaus, A.D., Fouchier, R.A., Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia (2012) N Engl J Med, 367, pp. 1814-1820; Middle East respiratory syndrome coronavirus (MERS-CoV) https://www.who.int/emergencies/mers-cov/en/, Available at: (Accessed 4 February 2020); Mobaraki, K., Ahmadzadeh, J., Current epidemiological status of Middle East respiratory syndrome coronavirus in the world from 1.1.2017 to 17.1.2018: a cross-sectional study (2019) BMC Infect Dis, 19, p. 351; MacIntyre, C.R., The discrepant epidemiology of Middle East respiratory syndrome coronavirus (MERS-CoV) (2014) Environ Syst Decis, 34; Das, K.M., Lee, E.Y., Al Jawder, S.E., Acute Middle East respiratory syndrome coronavirus: temporal lung changes observed on the chest radiographs of 55 patients (2015) AJR Am J Roentgenol, 205, pp. W267-W274; Das, K.M., Lee, E.Y., Langer, R.D., Larsson, S.G., Middle East respiratory syndrome coronavirus: what does a radiologist need to know? (2016) AJR Am J Roentgenol, 206, pp. 1193-1201; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395, pp. 507-513; Chan, J.F., Yuan, S., Kok, K.-H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, 395, pp. 514-523; Siegel, J.D., Rhinehart, E., Jackson, M., Chiarello, L., 2007 guideline for isolation precautions: preventing transmission of infectious agents in health care settings (2007) Am J Infect Control, 35 (10), pp. S65-S164; (2020), https://apps.who.int/iris/bitstream/handle/10665/331215/WHO-2019-nCov-IPCPPE_use-2020.1-eng.pdf, World Health Organization. Rational use of personal protective equipment for coronavirus disease 2019 (COVID-19). 2020, February 27; Accessed March 4; (2020), https://www.cdc.gov/coronavirus/2019-ncov/infection-control/control-recommendations.html?CDC_AA_refVal=https%3A%2F%2Fwww.cdc.gov%2Fcoronavirus%2F2019-ncov%2Fhcp%2Finfection-control.html, Centers for Disease Control and Prevention. Interim infection prevention and control recommendations for patients with confirmed coronavirus disease 2019 (COVID-19) or persons under investigation for COVID-19 in healthcare settings. 2020, February 21; Accessed March 4; Supplement I: infection control in health care, home, and community settings: public health guidance for community-level preparedness and response to severe acute respiratory syndrome (SARS) https://www.cdc.gov/sars/guidance/i-infection/index.html, Available at: (Accessed 2 February 2020); Seto, W.H., Tsang, D., Yung, R.W., Effectiveness of precautions against droplets and contact in prevention of nosocomial transmission of severe acute respiratory syndrome (SARS) (2003) Lancet, 361, pp. 1519-1520; Mirza, S.K., Tragon, T.R., Fukui, M.B., Hartman, M.S., Hartman, A.L., Microbiology for radiologists: how to minimize infection transmission in the radiology department (2015) Radiographics, 35, pp. 1231-1244","Gholamrezanezhad, A.; Division of Emergency Radiology, Department of Radiology, Keck School of Medicine, University of Sothern California, 1500 San Pablo Street, United States; email: ali.gholamrezanezhad@med.usc.edu",,Elsevier B.V.,15461440,,,32092296,English,J. Am. Coll. Radiol.,Article,Final,Open Access,Scopus,2-s2.0-85082304917,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Li G., Fan Y., Lai Y., Han T., Li Z., Zhou P., Pan P., Wang W., Hu D., Liu X., Zhang Q., Wu J.",57214800785;57214807747;57214923449;57214793578;57214804200;57214803991;57214799093;57193128543;57214793580;55717098300;57214795118;57188570786;,Coronavirus infections and immune responses,2020,Journal of Medical Virology,92,4,,424,432,,10,10.1002/jmv.25685,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079186085&doi=10.1002%2fjmv.25685&partnerID=40&md5=a729ec27cc87cc9298e79397d2381f95,"Guangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University, Guangzhou, China; Laboratory Animal Center, Guangzhou University of Chinese Medicine, Guangzhou, China; The First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China; The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China; School of Pubic Health, Southern Medical University, Guangzhou, China","Li, G., Guangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University, Guangzhou, China, Laboratory Animal Center, Guangzhou University of Chinese Medicine, Guangzhou, China; Fan, Y., The First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China; Lai, Y., The First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China; Han, T., The First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China; Li, Z., Laboratory Animal Center, Guangzhou University of Chinese Medicine, Guangzhou, China; Zhou, P., Guangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University, Guangzhou, China; Pan, P., Laboratory Animal Center, Guangzhou University of Chinese Medicine, Guangzhou, China; Wang, W., Guangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University, Guangzhou, China; Hu, D., State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China; Liu, X., The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China; Zhang, Q., Guangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University, Guangzhou, China, School of Pubic Health, Southern Medical University, Guangzhou, China; Wu, J., Guangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University, Guangzhou, China, State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China","Coronaviruses (CoVs) are by far the largest group of known positive-sense RNA viruses having an extensive range of natural hosts. In the past few decades, newly evolved Coronaviruses have posed a global threat to public health. The immune response is essential to control and eliminate CoV infections, however, maladjusted immune responses may result in immunopathology and impaired pulmonary gas exchange. Gaining a deeper understanding of the interaction between Coronaviruses and the innate immune systems of the hosts may shed light on the development and persistence of inflammation in the lungs and hopefully can reduce the risk of lung inflammation caused by CoVs. In this review, we provide an update on CoV infections and relevant diseases, particularly the host defense against CoV-induced inflammation of lung tissue, as well as the role of the innate immune system in the pathogenesis and clinical treatment. © 2020 Wiley Periodicals, Inc.",chemokine; coronavirus; cytokines; inflammation; interferon,"AY2 protein; cryopyrin; cytoplasmic DNA receptor; defensin; immunoglobulin enhancer binding protein; interferon; interferon induced helicase C domain containing protein 1; interferon regulatory factor 3; interleukin 1 receptor; interleukin 1 receptor associated kinase 1; interleukin 1 receptor associated kinase 2; interleukin 1 receptor associated kinase 3; interleukin 1 receptor associated kinase 4; LGP2 protein; myeloid differentiation factor 88; NLRC4 protein; NLRC5W protein; nucleotide binding oligomerization domain like receptor; nucleotide binding oligomerization domain like receptor 1; nucleotide binding oligomerization domain like receptor 6; receptor; retinoic acid inducible protein I; toll like receptor 2; toll like receptor 3; toll like receptor 4; toll like receptor 7; toll like receptor 9; toll like receptor adaptor molecule 2; tumor necrosis factor receptor associated factor 6; unclassified drug; unindexed drug; pattern recognition receptor; virus antibody; adaptive immunity; amino terminal sequence; antibody response; carboxy terminal sequence; CD4+ T lymphocyte; CD8+ T lymphocyte; dendritic cell; enzyme activation; enzyme inhibition; human; humoral immunity; immunopathogenesis; immunopathology; innate immunity; lung gas exchange; Middle East respiratory syndrome; Middle East respiratory syndrome coronavirus; nonhuman; protein expression; Review; SARS coronavirus; severe acute respiratory syndrome; signal transduction; adaptive immunity; animal; B lymphocyte; classification; Coronavirinae; Coronavirus infection; immunology; inflammation; innate immunity; lung; metabolism; pathology; physiology; T lymphocyte; ultrastructure; virus pneumonia; Adaptive Immunity; Animals; Antibodies, Viral; B-Lymphocytes; Coronavirus; Coronavirus Infections; Dendritic Cells; Humans; Immunity, Innate; Inflammation; Lung; Pneumonia, Viral; Receptors, Pattern Recognition; T-Lymphocytes","Laboratory testing of human suspected cases of novel coronavirus, , https://apps.who.int/iris/bitstream/handle/10665/330374/WHO-2019-nCoV-laboratory-2020.1-eng.pdf, (nCoV) infection [published online ahead of print January 21, 2020]; Novel Coronavirus (2019-nCoV) situation report-2, , https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200122-sitrep-2-2019-ncov.pdf, [published online ahead of print January 21, 2020]; Middle East respiratory syndrome coronavirus, , https://www.who.int/emergencies/mers-cov/en/, (MERS-CoV) [published online ahead of print January 21, 2020]; WHO MERS global summary and assessment of risk, , https://www.who.int/csr/disease/coronavirus_infections/risk-assessment-august-2018.pdf?ua=1, [published online ahead of print January 21, 2020]; 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van Doremalen, N., Falzarano, D., Ying, T., Efficacy of antibody-based therapies against Middle East respiratory syndrome coronavirus (MERS-CoV) in common marmosets (2017) Antiviral Res, 143, pp. 30-37; Coleman, C.M., Liu, Y.V., Mu, H., Purified coronavirus spike protein nanoparticles induce coronavirus neutralizing antibodies in mice (2014) Vaccine, 32 (26), pp. 3169-3174; Weingartl, H., Czub, M., Czub, S., Immunization with modified vaccinia virus Ankara-based recombinant vaccine against severe acute respiratory syndrome is associated with enhanced hepatitis in ferrets (2004) J Virol, 78 (22), pp. 12672-12676; Chen, W., Antibody response and viraemia during the course of severe acute respiratory syndrome (SARS)-associated coronavirus infection (2004) J Med Microbiol, 53, pp. 435-438","Wu, J.; Guangdong Provincial Key Laboratory of Virology, Institute of Medical Microbiology, Jinan UniversityChina; email: jwu898@jnu.edu.cn",,John Wiley and Sons Inc.,1466615,,JMVID,31981224,English,J. Med. Virol.,Review,Final,Open Access,Scopus,2-s2.0-85079186085,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Ji W., Wang W., Zhao X., Zai J., Li X.",57216090548;57214051736;57214897778;57191645661;57214468160;,Cross-species transmission of the newly identified coronavirus 2019-nCoV,2020,Journal of Medical Virology,92,4,,433,440,,32,10.1002/jmv.25682,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079901699&doi=10.1002%2fjmv.25682&partnerID=40&md5=068bb3d0245c6d2087b58e65af42e0e5,"Department of Microbiology, Peking University Health Science Center School of Basic Medical Sciences, Beijing, China; Department of Spleen and Stomach Diseases, The First affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, China; Department of Science and Technology, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, China; Immunology Innovation Team, School of Medicine, Ningbo University, Ningbo, China; Hubei Engineering Research Center of Viral Vector, Wuhan University of Bioengineering, Wuhan, China","Ji, W., Department of Microbiology, Peking University Health Science Center School of Basic Medical Sciences, Beijing, China; Wang, W., Department of Spleen and Stomach Diseases, The First affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, China; Zhao, X., Department of Science and Technology, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, China; Zai, J., Immunology Innovation Team, School of Medicine, Ningbo University, Ningbo, China; Li, X., Hubei Engineering Research Center of Viral Vector, Wuhan University of Bioengineering, Wuhan, China","The current outbreak of viral pneumonia in the city of Wuhan, China, was caused by a novel coronavirus designated 2019-nCoV by the World Health Organization, as determined by sequencing the viral RNA genome. Many initial patients were exposed to wildlife animals at the Huanan seafood wholesale market, where poultry, snake, bats, and other farm animals were also sold. To investigate possible virus reservoir, we have carried out comprehensive sequence analysis and comparison in conjunction with relative synonymous codon usage (RSCU) bias among different animal species based on the 2019-nCoV sequence. Results obtained from our analyses suggest that the 2019-nCoV may appear to be a recombinant virus between the bat coronavirus and an origin-unknown coronavirus. The recombination may occurred within the viral spike glycoprotein, which recognizes a cell surface receptor. Additionally, our findings suggest that 2019-nCoV has most similar genetic information with bat coronovirus and most similar codon usage bias with snake. Taken together, our results suggest that homologous recombination may occur and contribute to the 2019-nCoV cross-species transmission. © 2020 Wiley Periodicals, Inc.",2019-nCoV; codon usage bias; cross-species transmission; phylogenetic analysis; recombination,"cell surface receptor; glycoprotein; virus RNA; coronavirus spike glycoprotein; COVID-19; severe acute respiratory syndrome coronavirus 2; 2019 novel Coronavirus; Article; bat; China; codon usage; controlled study; Coronavirinae; coronavirus disease 2019; Coronavirus infection; cross species transmission; disease carrier; farm animal; gene sequence; homologous recombination; human; market; nonhuman; phylogeny; poultry; sequence analysis; snake; virus pneumonia; virus transmission; wildlife; World Health Organization; animal; Betacoronavirus; Bungarus; classification; Coronavirus infection; disease carrier; epidemic; genetics; host range; molecular evolution; Naja naja; physiology; virology; virus genome; virus pneumonia; zoonosis; Animals; Betacoronavirus; Bungarus; Chiroptera; Codon Usage; Coronavirus Infections; Disease Outbreaks; Disease Reservoirs; Evolution, Molecular; Genome, Viral; Homologous Recombination; Host Specificity; Humans; Naja naja; Phylogeny; Pneumonia, Viral; Snakes; Spike Glycoprotein, Coronavirus; Zoonoses","Chan, P.K., Outbreak of avian influenza A (H5N1) virus infection in Hong Kong in 1997 (2002) Clin Infect Dis, 34, pp. S58-S64; Guan, Y., Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China (2003) Science, 302, pp. 276-278; Yu, X.J., Liang, M.F., Zhang, S.Y., Fever with thrombocytopenia associated with a novel bunyavirus in China (2011) N Engl J Med, 364, pp. 1523-1532. , https://doi.org/10.1056/NEJMoa1010095; Lu, H., Stratton, C.W., Tang, Y.W., Outbreak of pneumonia of unknown etiology in Wuhan China: the mystery and the miracle (2020) J Med Virol, , https://doi.org/10.1002/jmv.25678; (2019) Coronavirus, , https://www.who.int/health-topics/coronavirus; 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Smith, R.D., Responding to global infectious disease outbreaks: lessons from SARS on the role of risk perception, communication and management (2006) Soc Sci Med, 63, pp. 3113-3123; Graham, R.L., Baric, R.S., Recombination, reservoirs, and the modular spike: mechanisms of coronavirus cross-species transmission (2010) J Virol, 84, pp. 3134-3146; Cunha, C.B., Opal, S.M., Middle East respiratory syndrome (MERS) A new zoonotic viral pneumonia (2014) Virulence, 5, pp. 650-654","Ji, W.; Department of Microbiology, Peking University Health Science Center School of Basic Medical SciencesChina; email: j102938@126.com",,John Wiley and Sons Inc.,1466615,,JMVID,31967321,English,J. Med. Virol.,Article,Final,Open Access,Scopus,2-s2.0-85079901699,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Benvenuto D., Giovanetti M., Ciccozzi A., Spoto S., Angeletti S., Ciccozzi M.",57208408457;55486066500;57214798105;7003817145;7003426796;8791594200;,The 2019-new coronavirus epidemic: Evidence for virus evolution,2020,Journal of Medical Virology,92,4,,455,459,,12,10.1002/jmv.25688,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079162868&doi=10.1002%2fjmv.25688&partnerID=40&md5=165e9af0d9b5139ca98d32987b977818,"Unit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome, Rome, Italy; Laboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil; Internal Medicine Unit, University Campus Bio-Medico of Rome, Rome, Italy; Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome, Rome, Italy","Benvenuto, D., Unit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome, Rome, Italy; Giovanetti, M., Laboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil; Ciccozzi, A., Unit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome, Rome, Italy; Spoto, S., Internal Medicine Unit, University Campus Bio-Medico of Rome, Rome, Italy; Angeletti, S., Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome, Rome, Italy; Ciccozzi, M., Laboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil","There is a worldwide concern about the new coronavirus 2019-nCoV as a global public health threat. In this article, we provide a preliminary evolutionary and molecular epidemiological analysis of this new virus. A phylogenetic tree has been built using the 15 available whole genome sequences of 2019-nCoV, 12 whole genome sequences of 2019-nCoV, and 12 highly similar whole genome sequences available in gene bank (five from the severe acute respiratory syndrome, two from Middle East respiratory syndrome, and five from bat SARS-like coronavirus). Fast unconstrained Bayesian approximation analysis shows that the nucleocapsid and the spike glycoprotein have some sites under positive pressure, whereas homology modeling revealed some molecular and structural differences between the viruses. The phylogenetic tree showed that 2019-nCoV significantly clustered with bat SARS-like coronavirus sequence isolated in 2015, whereas structural analysis revealed mutation in Spike Glycoprotein and nucleocapsid protein. From these results, the new 2019-nCoV is distinct from SARS virus, probably trasmitted from bats after mutation conferring ability to infect humans. © 2020 Wiley Periodicals, Inc.",coronavirus; epidemiology; macromolecular design; SARS coronavirus,"glycoprotein; spike glycoprotein; unclassified drug; coronavirus spike glycoprotein; severe acute respiratory syndrome coronavirus 2; 2019 novel coronavirus; Article; Bayes theorem; controlled study; Coronavirinae; fast unconstrained Bayesian approximation analysis; Middle East respiratory syndrome coronavirus; molecular evolution; mutational analysis; nonhuman; phylogenetic tree; SARS coronavirus; SARS-related coronavirus; sequence alignment; sequence homology; virus isolation; virus nucleocapsid; virus pathogenesis; whole genome sequencing; animal; bat; Betacoronavirus; Coronavirus infection; genetics; human; phylogeny; SARS coronavirus; Animals; Bayes Theorem; Betacoronavirus; Chiroptera; Coronavirus; Coronavirus Infections; Humans; Phylogeny; SARS Virus; Spike Glycoprotein, Coronavirus","Drosten, C., Günther, S., Preiser, W., Identification of a novel coronavirus associated with severe acute respiratory syndrome (2003) N Engl J Med, 348, pp. 1967-1976; Chen, Y., Liu, Q., Guo, D., Emerging coronaviruses: genome structure, replication, and pathogenesis (2020) J Med Virol, , https://doi.org/10.1002/jmv.25681; Chan, J.F.-W., Yuan, S., Kok, K.-H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, , https://doi.org/10.1016/S0140-6736(20)30154-9; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, , https://doi.org/10.1016/S0140-6736(20)30183-5; Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, , https://doi.org/10.1056/NEJMoa2001017; Hui, D.S., Azhar, E.I., Madani, T.A., The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health - The latest 2019 novel coronavirus outbreak in Wuhan, China (2020) Int J Infect Dis, 2020 (91), pp. 264-266; Lu, H., Stratton, C.W., Tang, Y.W., Outbreak of pneumonia of unknown etiology in Wuhan China: the mystery and the miracle (2020) J Med Virol, , https://doi.org/10.1002/jmv.25678; Ji, W., Wang, W., Zhao, X., Zai, J., Li, X., Homologous recombination within the spike glycoprotein of the newly identified coronavirus may boost cross-species transmission from snake to human (2020) J Med Virol, , https://doi.org/10.1002/jmv.25682; Katoh, K., Rozewicki, J., Yamada, K.D., MAFFT online service: multiple sequence alignment, interactive sequence choice and visualization (2019) Brief Bioinform, 20 (4), pp. 1160-1166. , https://doi.org/10.1093/bib/bbx108; Hall, T.A., BioEditA user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT (1999) Nucleic Acids Symp Ser, 41, pp. 95-98; Darriba, D., Taboada, G.L., Doallo, R., Posada, D., jModelTest 2: more models, new heuristics and parallel computing (2012) Nat Methods, 9 (8), p. 772; Kumar, S., Stecher, G., Li, M., Knyaz, C., Tamura, K., MEGA X: Molecular Evolutionary Genetics Analysis across computing platforms (2018) Mol Biol Evol, 35 (6), pp. 1547-1549; Murrell, B., Moola, S., Mabona, A., FUBAR: a fast, unconstrained bayesian approximation for inferring selection (2013) Mol Biol Evol, 30 (5), pp. 1196-1205; Murrell, B., Wertheim, J.O., Moola, S., Weighill, T., Scheffler, K., Kosakovsky Pond, S.L., Detecting individual sites subject to episodic diversifying selection (2012) PLoS Genet, 8 (7); Waterhouse, A., Bertoni, M., Bienert, S., SWISS-MODEL: homology modelling of protein structures and complexes (2018) Nucleic Acids Res, 46 (W1), pp. W296-W303; Zimmermann, L., Stephens, A., Nam, S.Z., A completely reimplemented MPI Bioinformatics Toolkit with a new HHpred server at its core (2018) J Mol Biol, 430 (15), pp. 2237-2243; Benkert, P., Künzli, M., Schwede, T., QMEAN server for protein model quality estimation (2009) Nucleic Acids Res, 37 (W), pp. W510-W514. , 2009; (2015) The {PyMOL} Molecular Graphics System, Version~1.8; Chakraborty, S., Nag, D., Mazumder, T.H., Uddin, A., Codon usage pattern and prediction of gene expression level in Bungarus species (2016) Gene, 604, pp. 48-60. , https://doi.org/10.1016/j.gene.2016.11.023","Angeletti, S.; Unit of Clinical Laboratory Science, University Campus Bio-Medico of RomeItaly; email: s.angeletti@unicampus.it",,John Wiley and Sons Inc.,1466615,,JMVID,31994738,English,J. Med. Virol.,Article,Final,Open Access,Scopus,2-s2.0-85079162868,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wei J., Xu H., Xiong J., Shen Q., Fan B., Ye C., Dong W., Hu F.",57215859716;57215860081;57215087734;57215858825;57215081757;57215855394;57215858699;57215861139;,2019 novel coronavirus (Covid-19) pneumonia: Serial computed tomography findings,2020,Korean Journal of Radiology,21,4,,494,497,,,10.3348/kjr.2020.0112,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082132395&doi=10.3348%2fkjr.2020.0112&partnerID=40&md5=95dfa6f936d4cc0b2af6d55020d21aa1,"Departments of Radiology, Jiangxi Provincial People’s Hospital, Nanchang, China; Departments of Medical Cosmetology, Jiangxi Provincial People’s Hospital, Nanchang, China; Department of Radiology, Jiangxi Chest Hospital, Nanchang, China; Institute of Clinical Medicine, Jiangxi Provincial People’s Hospital, Nanchang, China","Wei, J., Departments of Radiology, Jiangxi Provincial People’s Hospital, Nanchang, China; Xu, H., Departments of Medical Cosmetology, Jiangxi Provincial People’s Hospital, Nanchang, China; Xiong, J., Department of Radiology, Jiangxi Chest Hospital, Nanchang, China; Shen, Q., Institute of Clinical Medicine, Jiangxi Provincial People’s Hospital, Nanchang, China; Fan, B., Departments of Radiology, Jiangxi Provincial People’s Hospital, Nanchang, China; Ye, C., Departments of Radiology, Jiangxi Provincial People’s Hospital, Nanchang, China; Dong, W., Departments of Radiology, Jiangxi Provincial People’s Hospital, Nanchang, China; Hu, F., Departments of Radiology, Jiangxi Provincial People’s Hospital, Nanchang, China","From December 2019, Coronavirus disease 2019 (COVID-19) pneumonia (formerly known as the 2019 novel Coronavirus [2019-nCoV]) broke out in Wuhan, China. In this study, we present serial CT findings in a 40-year-old female patient with COVID-19 pneumonia who presented with the symptoms of fever, chest tightness, and fatigue. She was diagnosed with COVID-19 infection confirmed by real-time reverse-transcriptase-polymerase chain reaction. CT showed rapidly progressing peripheral consolidations and ground-glass opacities in both lungs. After treatment, the lesions were shown to be almost absorbed leaving the fibrous lesions. © 2020 The Korean Society of Radiology.",2019-nCoV; Coronavirus; COVID-19; Pneumonia; Tomography; X-ray computed,"antivirus agent; C reactive protein; lopinavir; piperacillin; tazobactam; virus DNA; COVID-19; 2019 novel coronavirus; adult; Article; body temperature; case report; chest tightness; clinical article; computer assisted tomography; coronavirus disease 2019; coronavirus disease 2019; coughing; disease exacerbation; eosinophilia; fatigue; female; fever; fibrous lesion; follow up; gene amplification; ground glass opacity; hospital discharge; human; leukopenia; nodular consolidation; parenchymal lesion; perilobular thickening; peripheral patchy area; pneumonia; real time reverse transcription polymerase chain reaction; respiratory tract parameters; right lung; subpleural area; thorax radiography; Coronavirus infection; diagnostic imaging; fever; lung; virus pneumonia; x-ray computed tomography; Adult; Coronavirus Infections; Female; Fever; Humans; Lung; Pneumonia, Viral; Tomography, X-Ray Computed","Rubin, E.J., Baden, L.R., Morrissey, S., Campion, E.W., Medical journals and the 2019-nCoV outbreak (2020) N Engl J Med, , https://doi.org/10.1056/NEJMe2001329; Emerging understandings of 2019-nCoV (2020) The Lancet, 395, p. 311; Carlos, W.G., Dela Cruz, C.S., Cao, B., Pasnick, S., Jamil, S., Novel Wuhan (2019-nCoV) Coronavirus (2020) Am J Respir Crit Care Med, 201, pp. P7-P8; Lei, J., Li, J., Li, X., Qi, X., CT imaging of the 2019 Novel Coronavirus (2019-nCoV) pneumonia (2020) Radiology, , https://doi.org/10.1148/radiol.2020200236; Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., China Novel Coronavirus Investigating and Research Team. A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, , https://doi.org/10.1056/NEJMoa2001017; Lu, H., Drug treatment options for the 2019-new Coronavirus (2019-nCoV) (2020) Biosci Trends, , https://doi.org/10.5582/bst.2020.01020; Corman, V.M., Landt, O., Kaiser, M., Molenkamp, R., Meijer, A., Chu, D.K., Detection of 2019 novel Coronavirus (2019-nCoV) by real-time RT-PCR (2020) Euro Surveill, 25; Gralinski, L.E., Menachery, V.D., Return of the Coronavirus: 2019-nCoV (2020) Viruses, p. 12; Lin, X., Gong, Z., Xiao, Z., Xiong, J., Fan, B., Liu, J., Novel Coronavirus pneumonia outbreak in 2019: Computed tomographic findings in two cases (2020) Korean J Radiol, 21, pp. 365-368","Fan, B.; Department of Radiology, Jiangxi Provincial People’s Hospital, Aiguo Road No. 92, Donghu District, China; email: 26171381@qq.com",,Korean Radiological Society,12296929,,,32100486,English,Korean J. Radiol.,Article,Final,,Scopus,2-s2.0-85082132395,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Li D., Wang D., Dong J., Wang N., Huang H., Xu H., Xia C.",57215858753;57214826500;57215860668;57215858064;57215863171;57215860089;57215854821;,False-negative results of real-time reverse-transcriptase polymerase chain reaction for severe acute respiratory syndrome coronavirus 2: Role of deep-learning-based ct diagnosis and insights from two cases,2020,Korean Journal of Radiology,21,4,,505,508,,,10.3348/kjr.2020.0146,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082129893&doi=10.3348%2fkjr.2020.0146&partnerID=40&md5=9146ca4b1bc1b24b8551bf1e6a66abf5,"Departments of Radiology, Beijing Haidian Section of Peking University Third Hospital (Beijing Haidian Hospital), Beijing, China; Departments of Infection, Beijing Haidian Section of Peking University Third Hospital (Beijing Haidian Hospital), Beijing, China; Institute of Advanced Research, Infervision, Beijing, China","Li, D., Departments of Radiology, Beijing Haidian Section of Peking University Third Hospital (Beijing Haidian Hospital), Beijing, China; Wang, D., Institute of Advanced Research, Infervision, Beijing, China; Dong, J., Departments of Infection, Beijing Haidian Section of Peking University Third Hospital (Beijing Haidian Hospital), Beijing, China; Wang, N., Departments of Radiology, Beijing Haidian Section of Peking University Third Hospital (Beijing Haidian Hospital), Beijing, China; Huang, H., Departments of Radiology, Beijing Haidian Section of Peking University Third Hospital (Beijing Haidian Hospital), Beijing, China; Xu, H., Departments of Radiology, Beijing Haidian Section of Peking University Third Hospital (Beijing Haidian Hospital), Beijing, China; Xia, C., Institute of Advanced Research, Infervision, Beijing, China","The epidemic of 2019 novel coronavirus, later named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still gradually spreading worldwide. The nucleic acid test or genetic sequencing serves as the gold standard method for confirmation of infection, yet several recent studies have reported false-negative results of real-time reverse-transcriptase polymerase chain reaction (rRT-PCR). Here, we report two representative false-negative cases and discuss the supplementary role of clinical data with rRT-PCR, including laboratory examination results and computed tomography features. Coinfection with SARS-COV-2 and other viruses has been discussed as well. © 2020 The Korean Society of Radiology.",Computed tomography; COVID-19; False-negative results; Laboratory examination; RRT-PCR; SARS-COV-2,"C reactive protein; COVID-19; severe acute respiratory syndrome coronavirus 2; 2019 novel coronavirus; adult; Article; body temperature; case report; clinical article; computer assisted tomography; coronavirus disease 2019; deep learning; diagnostic test accuracy study; diffuse ground glass opacity; dry throat; dyspnea; false negative result; fever; human; infant; influenza A; leukocyte count; lung disease; lung emphysema; lung lesion; lymphocyte count; male; neutrophil count; nonhuman; nucleic acid analysis; physical examination; pneumonia; real time reverse transcription polymerase chain reaction; SARS coronavirus; severe acute respiratory syndrome coronavirus 2; virus pneumonia; Betacoronavirus; Coronavirus infection; diagnostic imaging; false negative result; genetics; isolation and purification; reverse transcription polymerase chain reaction; virology; x-ray computed tomography; Adult; Betacoronavirus; Coronavirus Infections; Deep Learning; False Negative Reactions; Humans; Infant; Male; Pneumonia, Viral; Reverse Transcriptase Polymerase Chain Reaction; Tomography, X-Ray Computed","Gorbalenya, A.E., Baker, S.C., Baric, R.S., de Groot, R.J., Drosten, C., Gulyaeva, A.A., Severe acute respiratory syndrome-related coronavirus: The species and its viruses – a statement of the Coronavirus Study Group (2020) Biorxiv, , https://doi.org/10.1101/2020.02.07.937862; Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., China Novel Coronavirus Investigating and Research Team. A novel Coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382, pp. 727-733; Xie, X., Zhong, Z., Zhao, W., Zheng, C., Wang, F., Liu, J., Chest CT for typical 2019-nCoV pneumonia: Relationship to negative RT-PCR testing (2020) Radiology, , https://doi.org/10.1148/radiol.2020200343; Chung, M., Bernheim, A., Mei, X., Zhang, N., Huang, M., Zeng, X., CT imaging features of 2019 novel Coronavirus (2019-nCoV) (2020) Radiology, , https://doi.org/10.1148/radiol.2020200230; (2020), National Health Commission of the People’s Republic of China. Diagnosis and treatment protocols of pneumonia caused by a novel coronavirus (trial version 5). Beijing: National Health Commission of the People's Republic of China","Li, D.; Department of Radiology, Beijing Haidian Section of Peking University Third Hospital (Beijing Haidian Hospital), 29 Zhongguancun Rd, Haidian District, China; email: 724501143@qq.com",,Korean Radiological Society,12296929,,,32174053,English,Korean J. Radiol.,Article,Final,,Scopus,2-s2.0-85082129893,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Singhal T.,57205723121;,A Review of Coronavirus Disease-2019 (COVID-19),2020,Indian Journal of Pediatrics,87,4,,281,286,,,10.1007/s12098-020-03263-6,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081932858&doi=10.1007%2fs12098-020-03263-6&partnerID=40&md5=d21e8722dcc3dbc45151af81a8030ed6,"Department of Pediatrics and Infectious Disease, Kokilaben Dhirubhai Ambani Hospital and Medical Research Institute, Mumbai, India","Singhal, T., Department of Pediatrics and Infectious Disease, Kokilaben Dhirubhai Ambani Hospital and Medical Research Institute, Mumbai, India","There is a new public health crises threatening the world with the emergence and spread of 2019 novel coronavirus (2019-nCoV) or the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The virus originated in bats and was transmitted to humans through yet unknown intermediary animals in Wuhan, Hubei province, China in December 2019. There have been around 96,000 reported cases of coronavirus disease 2019 (COVID-2019) and 3300 reported deaths to date (05/03/2020). The disease is transmitted by inhalation or contact with infected droplets and the incubation period ranges from 2 to 14 d. The symptoms are usually fever, cough, sore throat, breathlessness, fatigue, malaise among others. The disease is mild in most people; in some (usually the elderly and those with comorbidities), it may progress to pneumonia, acute respiratory distress syndrome (ARDS) and multi organ dysfunction. Many people are asymptomatic. The case fatality rate is estimated to range from 2 to 3%. Diagnosis is by demonstration of the virus in respiratory secretions by special molecular tests. Common laboratory findings include normal/ low white cell counts with elevated C-reactive protein (CRP). The computerized tomographic chest scan is usually abnormal even in those with no symptoms or mild disease. Treatment is essentially supportive; role of antiviral agents is yet to be established. Prevention entails home isolation of suspected cases and those with mild illnesses and strict infection control measures at hospitals that include contact and droplet precautions. The virus spreads faster than its two ancestors the SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV), but has lower fatality. The global impact of this new epidemic is yet uncertain. © 2020, Dr. K C Chaudhuri Foundation.",2019-nCOV; COVID-19; Pneumonia; Review; SARS-CoV-2,"antibiotic agent; antifungal agent; antivirus agent; arbidol; C reactive protein; chloroquine; corticosteroid; ganciclovir; glucocorticoid; herbaceous agent; hypochlorite sodium; immunoglobulin; interferon; lopinavir plus ritonavir; oseltamivir; remdeswir; ribavirin; unclassified drug; COVID-19; severe acute respiratory syndrome coronavirus 2; adult respiratory distress syndrome; artificial ventilation; asymptomatic infection; bat; case fatality rate; China; Chinese herb; clinical feature; comorbidity; continuous renal replacement therapy; coronavirus disease 2019; Coronavirus infection; coughing; decontamination; differential diagnosis; dyspnea; extracorporeal oxygenation; fatigue; fever; geriatrics; government; hand washing; health care personnel; high risk population; history of medicine; home care; hospital patient; Hubei; human; incubation time; infection control; isolation; leukocyte count; lung lavage; malaise; Middle East respiratory syndrome coronavirus; mixed infection; molecular diagnosis; multiple organ failure; multiplex polymerase chain reaction; nasopharyngeal swab; noninvasive ventilation; oxygen therapy; pandemic; pathogenesis; patient counseling; plasma; pneumonia; positive-strand RNA virus; public health; renal replacement therapy; Review; room ventilation; SARS coronavirus; Severe acute respiratory syndrome coronavirus 2; sore throat; sputum; sunlight; thorax radiography; throat culture; tracheal aspiration procedure; travel; virus transmission; Wuhan; x-ray computed tomography; Betacoronavirus; complication; Coronavirus infection; coughing; dyspnea; epidemic; fatigue; fever; pharyngitis; virus pneumonia; Betacoronavirus; Coronavirus Infections; Cough; Disease Outbreaks; Dyspnea; Fatigue; Fever; Humans; Pharyngitis; Pneumonia, Viral","Wang, C., Horby, P.W., Hayden, F.G., Gao, G.F., A novel coronavirus outbreak of global health concern (2020) The Lancet, 395 (10223), pp. 470-473; Coronavirus Outbreak, , https://www.worldometers.info/coronavirus/, Available at, Accessed 23 Feb 2020; Richman, D.D., Whitley, R.J., Hayden, F.G., (2016) Clinical Virology, , Washington, ASM Press; Chan-Yeung, M., Xu, R.H., SARS: epidemiology (2003) Respirology., 8, pp. S9-S14; Middle East Respiratory Syndrome Coronavirus, , https://www.who.int/emergencies/mers-cov/en/, Accessed 16 Feb 2020; Situation Reports, , https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports/, Accessed 22 Feb 2020; China’s CDC Detects a Large Number of New Coronaviruses in the South China Seafood Market in Wuhan, , https://www.xinhuanet.com/2020-01/27/c_1125504355.htm, Xinhua, Accessed 20 Feb 2020; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Cao, B., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506. , COI: 1:CAS:528:DC%2BB3cXhs1Kqu7c%3D; Rothe, C., Schunk, M., Sothmann, P., Bretzel, G., Froeschl, G., Wallrauch, C., Zimmer, T., Hoelscher, M., Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany (2020) New England Journal of Medicine, 382 (10), pp. 970-971; Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med, , https://doi.org/10.1056/NEJMoa2001316; Cheng, Z.J., Shan, J., 2019 novel coronavirus: Where we are and what we know (2020) Infection, pp. 1-9. , https://doi.org/10.1007/s15010-020-01401-y; Zou, L., Ruan, F., Huang, M., SARS-CoV-2 viral load in upper respiratory specimens of infected patients (2020) N Engl J Med, , https://doi.org/10.1056/NEJMc2001737; Kampf, G., Todt, D., Pfaender, S., Steinmann, E., Persistence of coronaviruses on inanimate surfaces and its inactivation with biocidal agents (2020) J Hosp Infect, 20, pp. S0195-S6701. , Feb 6; Chen, H., Guo, J., Wang, C., Luo, F., Yu, X., Zhang, W., Li, J., Zhang, Y., Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records (2020) The Lancet, 395 (10226), pp. 809-815; Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Zhang, L., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet., 395, pp. 507-513. , COI: 1:CAS:528:DC%2BB3cXhvFOmsb8%3D; Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Wang, B., Peng, Z., Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China (2020) JAMA, 323 (11), p. 1061; Xu, X.W., Wu, X.X., Jiang, X.G., Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series (2020) BMJ, 368, p. m606; Wang, X.F., Yuan, J., Zheng, Y.J., Clinical and epidemiological characteristics of 34 children with 2019 novel coronavirus infection in Shenzhen (2020) Zhonghua Er Ke Za Zhi, 58, p. E008. , Article in Chinese; Chen, F., Liu, Z.S., Zhang, F.R., First case of severe childhood novel coronavirus pneumonia in China (2020) Zhonghua Er Ke Za Zhi, 58, p. E005. , COI: 1:STN:280:DC%2BB387gvFSisA%3D%3D, PID: 32045966; Zeng, L.K., Tao, X.W., Yuan, W.H., Wang, J., Liu, X., Liu, Z.S., First case of neonate infected with novel coronavirus pneumonia in China (2020) Zhonghua Er Ke Za Zhi, 58, p. E009. , COI: 1:STN:280:DC%2BB387ivVGmtQ%3D%3D, PID: 32065520; Jin, Y.H., Cai, L., Cheng, Z.S., A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus [2019-nCoV] infected pneumonia [standard version] (2020) Mil Med Res, 7, p. 4; Huang, P., Liu, T., Huang, L., Liu, H., Lei, M., Xu, W., Hu, X., Liu, B., Use of Chest CT in Combination with Negative RT-PCR Assay for the 2019 Novel Coronavirus but High Clinical Suspicion (2020) Radiology, 295 (1), pp. 22-23; Chen, Z.-M., Fu, J.-F., Shu, Q., Diagnosis and treatment recommendations for pediatric respiratory infection caused by the 2019 novel coronavirus (2020) World J Pediatr, pp. 1-7. , https://doi.org/10.1007/s12519-020-00345-5; Russell, C.D., Millar, J.E., Baillie, J.K., Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury (2020) Lancet., 395, pp. 473-475. , COI: 1:CAS:528:DC%2BB3cXisFaksr4%3D; Zhao, J.P., Hu, Y., Du, R.H., Expert consensus on the use of corticosteroid in patients with 2019-nCoV pneumonia (2020) Zhonghua Jie He He Hu Xi Za Zhi, 43, p. E007. , COI: 1:STN:280:DC%2BB38%2Fpsl2rsw%3D%3D, PID: 32034899; Clinical Management of Severe Acute Respiratory Infection When Novel Coronavirus [Ncov] Infection is Suspected, , https://www.who.int/publications-detail/clinical-management-of-severe-acute-respiratory-infection-when-novelcoronavirus-[ncov]-infection-is-suspected, Accessed 9 Feb 2020; Holshue, M.L., DeBolt, C., Lindquist, S., Lofy, K.H., Wiesman, J., Bruce, H., Spitters, C., Pillai, S.K., First Case of 2019 Novel Coronavirus in the United States (2020) New England Journal of Medicine, 382 (10), pp. 929-936; Zhang, L., Liu, Y., Potential interventions for novel coronavirus in China: A systematic review (2020) Journal of Medical Virology, 92 (5), pp. 479-490; Multicenter Collaboration Group of Department of Science and Technology of Guangdong Province and Health Commission of Guangdong Province for Chloroquine in the Treatment of Novel Coronavirus Pneumonia (2020) Zhonghua Jie He He Hu Xi Za Zhi, 43, p. E019. , Expert consensus on chloroquine phosphate for the treatment of novel coronavirus pneumonia]. [Article in Chinese; Coronavirus Disease [COVID-19] Technical Guidance: Infection Prevention and Control, , https://www.who.int/emergencies/diseases/novel-coronavirus-2019/technical-guidance/infection-prevention-and-control, Accessed 20 Feb 2020; Chang, D., Xu, H., Rebaza, A., Sharma, L., Dela Cruz, C.S., Protecting health-care workers from subclinical coronavirus infection (2020) The Lancet Respiratory Medicine, 8 (3); Li, J., Li, J.J., Xie, X., Cai, X., Huang, J., Tian, X., Zhu, H., Game consumption and the 2019 novel coronavirus (2020) The Lancet Infectious Diseases, 20 (3), pp. 275-276","Singhal, T.; Department of Pediatrics and Infectious Disease, Kokilaben Dhirubhai Ambani Hospital and Medical Research InstituteIndia; email: tanusinghal@yahoo.com",,Springer,195456,,IJPEA,32166607,English,Indian J. Pediatr.,Review,Final,Open Access,Scopus,2-s2.0-85081932858,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Ung C.O.L.,55786677600;,Community pharmacist in public health emergencies: Quick to action against the coronavirus 2019-nCoV outbreak,2020,Research in Social and Administrative Pharmacy,16,4,,583,586,,,10.1016/j.sapharm.2020.02.003,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079362164&doi=10.1016%2fj.sapharm.2020.02.003&partnerID=40&md5=ab27cc44dbeb064322d8dbb7d586e999,"State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, N22 Building, Taipa, Room 2058, Macau","Ung, C.O.L., State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, N22 Building, Taipa, Room 2058, Macau","The 2019-nCoV infection that is caused by a novel strain of coronavirus was first detected in China in the end of December 2019 and declared a public health emergency of international concern by the World Health Organization on January 30, 2020. Community pharmacists in one of the first areas that had confirmed cases of the viral infection, Macau, joined the collaborative force in supporting the local health emergency preparedness and response arrangements. This paper aimed to improve the understanding of community pharmacists’ role in case of 2019-CoV outbreak based on the practical experiences in consultation with the recommendations made by the International Pharmaceutical Federation on the Coronavirus 2019-nCoV outbreak. © 2020 Elsevier Inc.",2019-nCoV; Community pharmacy; Macau; Outbreak; Pharmacist,"community pharmacist; consultation; Coronavirinae; human; Macao; nonhuman; note; pharmacy (shop); public health; Betacoronavirus; Coronavirus infection; emergency; epidemic; epidemiological monitoring; hygiene; Macao; mask; organization and management; patient education; pharmacist; pharmacy (shop); virus pneumonia; Betacoronavirus; Community Pharmacy Services; Coronavirus Infections; Disease Outbreaks; Emergencies; Epidemiological Monitoring; Humans; Hygiene; Macau; Masks; Patient Education as Topic; Pharmacists; Pneumonia, Viral; Public Health","Information Bureau, Macao Sar Government, Press Release “Macao Sparing No Effort to Prevent the Spread Locally of a New Coronavirus” on 22 January 2020 (2020), https://news.gov.mo/detail/en/N20AV4AiJe?2, (Accessed 9 February 2020); Information Bureau, Macao Sar Government, Press Release “Updates on the New Coronavirus” on 8 February 2020 (2020), https://news.gov.mo/detail/zh-hant/N20BHx8ATv?8, (Accessed 9 February 2020); Information Bureau, Macao Sar Government, Press Release “SAR Government Raises Warning Level for “unknown Cause of Pneumonia in Wuhan” to Level III (Heavier)” on 5 January 2020 (2020), https://news.gov.mo/detail/zh-hant/N20AEUUwwZ?9, (Accessed 9 February 2020); World Health Organization, Novel Coronavirus (2019-nCoV): Strategic Preparedness and Response Plan (Draft as of 3 February 2020) (2019), https://www.who.int/docs/default-source/coronaviruse/srp-04022020.pdf, 2020 (Accessed 9 February 2020); Gralinski, L.E., Menachery, V.D., Return of the coronavirus: 2019-nCoV (2020) Viruses, 12 (2), p. 135; World Health Organization (WHO) Emergency Committee, Statement on the Second Meeting of the International Health Regulations (2005) Emergency Committee Regarding the Outbreak of Novel Coronavirus (2019-nCoV). Geneva:WHO; 30 January 2020 (2020), https://www.who.int/news-room/detail/30-01-2020-statement-on-the-second-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-outbreak-of-novel-coronavirus-(2019-ncov, (Accessed 9 February 2020); World Health Organization, Novel Coronavirus(2019-nCoV) Situation Report-18 (2020), https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200207-sitrep-18-ncov.pdf?sfvrsn=fa644293_2, (Accessed 9 February 2020); International Pharmaceutical Federation, Coronavirus 2019-nCoV Outbreak: Information and Interim Guidelines for Pharmacists and the Pharmacy Workforce (2020), https://www.fip.org/file/4413, (Accessed 9 February 2020); Peiris, J.S., Guan, Y., Yuen, K.Y., Severe acute respiratory syndrome (2004) Nat Med, 10, pp. S88-S97; Chan-Yeung, M., Xu, R.H., (2003) SARS: Epidemiol Respirol, 8, pp. S9-S14; SARS Expert Committee, The Hong Kong SAR government (2003) SARS in Hong Kong: From Experience to Action: Summary Report, , https://www.sars-expertcom.gov.hk/english/reports/summary/files/e_sumrpt_sect1.pdf, (Accessed 9 February 2020); Zaki, A.M., van Boheemen, S., Bestebroer, T.M., Osterhaus, A.D., Fouchier, R.A., Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia (2012) N Engl J Med, 367, pp. 1814-1820; (2020) National Institute of Allergy and Infectious Diseases, National Institute of Health. Coronaviruses, , https://www.niaid.nih.gov/diseases-conditions/coronaviruses, (Accessed 9 February 2020); Wuhan Municipal Health and Health Commission's Briefing on the Current Pneumonia Epidemic Situation in Our City (2020), http://wjw.wuhan.gov.cn/front/web/showDetail/2019123108989, (Accessed 9 February 2020); Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet; World Health Organization, Advice on the Use of Masks in the Community, during Home Care and in Health Care Settings in the Context of the Novel Coronavirus (2019-nCoV) Outbreak (2020), https://www.who.int/publications-detail/advice-on-the-use-of-masks-the-community-during-home-care-and-in-health-care-settings-in-the-context-of-the-novel-coronavirus-(2019-ncov)-outbreak, (Accessed 9 February 2020); Lu, R., Zhao, X., Li, J., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet; (2020) GSAID Database. 2020 Coronavirus, , https://www.gisaid.org/CoV2020/, (Accessed 9 February 2020); Information Bureau, Macao Sar Government, Press Release “Full Recovery of the First New Coronavirus Case in Macao” on 6 February 2020 (2020), https://news.gov.mo/detail/zh-hant/N20BFr6ANe?11, (Accessed 9 February 2020); World Health Organization, WHO Guidelines on Hand Hygiene in Health Care: A Summary (2009), https://www.who.int/gpsc/5may/tools/who_guidelines-handhygiene_summary.pdf, (Accessed 9 February 2020); World Health Organization, Hand Hygiene: Why, How and when? (2009), https://www.who.int/gpsc/5may/Hand_Hygiene_Why_How_and_When_Brochure.pdf, (Accessed 9 February 2020); Information Bureau, Macao Sar Government, Press Release “Updates on New Coronavirus” on 7 February 2020 (2020), https://www.gov.mo/zh-hant/news/317427/, (Accessed 9 February 2020); World Health Organization, Guide to Local Production: WHO-Recommended Handrubs Formulations (2010), https://www.who.int/gpsc/5may/Guide_to_Local_Production.pdf, (Accessed 9 February 2020); The Hong Kong Sar Government, Wearing mask https://www.info.gov.hk/info/sars/en/facemask.htm, (Accessed 9 February 2020); World Health Organization, Advice on the Use of Masks the Community, during Home Care and in Health Care Settings in the Context of the Novel Coronavirus (2019-nCoV) Outbreak Interim Guidance (2020), file:///C:/Users/carolinaung/Downloads/advice-on-the-use-of-masks-2019-ncov.pdf, (Accessed 9 February 2020); Surgical Masks-Premarket Notification [51-(k0) Submissions. Guidance for Industry and FDA Staff (2018), https://www.fda.gov/regulatory-information/search-fda-guidance-documents/surgical-masks-premarket-notification-510k-submissions, (Accessed 9 February 2020); (2019) European Standards. UNE EN 14683:2019+AC:2019. Medical Face Masks - Requirements and Test Methods, , https://www.en-standard.eu/une-en-14683-2019-ac-2019-medical-face-masks-requirements-and-test-methods/, (Accessed 9 February 2020); World Health Organization, Novel coronavirus (2019-ncov)v2 operational support & logistics disease commodity packages https://www.who.int/docs/default-source/coronaviruse/dcp--ncov.pdf?sfvrsn=f5fe6234_4&download=true;2020 2019, (Accessed 9 February 2020); Information Bureau, Macao Sar Government, Press Release “The Guaranteed Mask Supply for Macao Residents Scheme” on 22 January 2020 (2020), https://news.gov.mo/detail/zh-hant/N20AVJspef?14, (Accessed 9 February 2020); Macao Sar Government, Special Webpage against Epidemics (2020), https://www.ssm.gov.mo/apps1/PreventWuhanInfection/en.aspx#clg17311, (Accessed 9 February 2020)",,,Elsevier Inc.,15517411,,,32081569,English,Res. Soc. Adm. Pharm.,Note,Final,Open Access,Scopus,2-s2.0-85079362164,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Gudi S.K., Tiwari K.K.",57205457749;57210237871;,Preparedness and Lessons Learned from the Novel Coronavirus Disease,2020,The international journal of occupational and environmental medicine,11,2,,108,112,,,10.34172/ijoem.2020.1977,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082562016&doi=10.34172%2fijoem.2020.1977&partnerID=40&md5=cbf0dd5874c06f950487389f4be382db,"College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Canada; Winnipeg, MB, Canada","Gudi, S.K., College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Canada; Tiwari, K.K., Winnipeg, MB, Canada","In a short span, a novel coronavirus (SARS-CoV-2) has captured global consciousness by significantly affecting the day-to-day life of humans and emerged as a public health emergency. Undoubtedly, it indicates that lessons learnt from the past epidemics of coronaviruses such as the Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS), had not enough and thus left us ill-prepared to deal with the challenges that COVID-19 pandemic is currently posing. Currently, as a global pandemic, COVID-19 poses major challenges and thus forcing the entire world to lockdown. However, the disease has prepared humankind in facing such outbreaks at present as well as in the future. Besides, it has also taught numerous lessons that are worth considering and implementing to make the world a better reality.",Coronavirus; COVID-19 [Supplementary Concept]; Disease outbreaks; Pandemics; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2 [Supplementary Concept]; Social distancing; Universal precautions,,,,,NLM (Medline),20086814,,,32218558,English,Int J Occup Environ Med,Article,Final,,Scopus,2-s2.0-85082562016,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Han Q., Lin Q., Jin S., You L.",57204127908;57212513379;57193319357;54951206100;,Coronavirus 2019-nCoV: A brief perspective from the front line,2020,Journal of Infection,80,4,,373,377,,,10.1016/j.jinf.2020.02.010,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081244162&doi=10.1016%2fj.jinf.2020.02.010&partnerID=40&md5=f08095d14352fdc3e02b31a323a10f3d,"Department of Hematology, the First Affiliated Hospital, College of Medicine, Zhejiang University, 79# Qingchun Road, Hangzhou, Zhejiang 310003, China; Malignant Lymphoma Diagnosis and Therapy Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China; Institute of Hematology, Zhejiang University, Hangzhou, Zhejiang 31003, China; Department of Hematology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, China","Han, Q., Department of Hematology, the First Affiliated Hospital, College of Medicine, Zhejiang University, 79# Qingchun Road, Hangzhou, Zhejiang 310003, China, Malignant Lymphoma Diagnosis and Therapy Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China, Institute of Hematology, Zhejiang University, Hangzhou, Zhejiang 31003, China; Lin, Q., Department of Hematology, the First Affiliated Hospital, College of Medicine, Zhejiang University, 79# Qingchun Road, Hangzhou, Zhejiang 310003, China, Malignant Lymphoma Diagnosis and Therapy Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China, Institute of Hematology, Zhejiang University, Hangzhou, Zhejiang 31003, China; Jin, S., Department of Hematology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, China; You, L., Department of Hematology, the First Affiliated Hospital, College of Medicine, Zhejiang University, 79# Qingchun Road, Hangzhou, Zhejiang 310003, China, Malignant Lymphoma Diagnosis and Therapy Center, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, China, Institute of Hematology, Zhejiang University, Hangzhou, Zhejiang 31003, China","A novel coronavirus, designated as 2019-nCoV, hit the central Chinese city of Wuhan in late December 2019, and subsequently spread rapidly to all provinces of China and multiple countries. As of 0:00 am February 9, 2020, a total of 37,287 cases have been confirmed infection of 2019-nCoV in China mainland, and 302 cases have also been cumulatively reported from 24 countries. According to the latest data, a total of 813 deaths occurred in China mainland, with the mortality reaching approximately 2.2%. At present, there is no vaccine or specific drugs for the human coronavirus. Therefore, it is critical to understand the nature of the virus and its clinical characteristics, in order to respond to the 2019-nCoV outbreak. Thus, the present study briefly but comprehensively summarizes the not much but timely reports on the 2019-nCoV. © 2020",2019-nCoV; Epidemiology; Genomic; Therapeutic,5' untranslated region; clinical feature; Coronaviridae; coronavirus disease 2019; Coronavirus infection; epidemic; human; mortality rate; nonhuman; open reading frame; Review; severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; virus genome; virus morphology,"Fehr, A.R., Perlman, S., Coronaviruses: an overview of their replication and pathogenesis (2015) Methods Mol Biol, 1282, pp. 1-23; Li, G., Fan, Y., Lai, Y., Coronavirus infections and immune responses (2020) J Med Virol, 92, pp. 424-432; Cui, J., Li, F., Shi, Z.-L., Origin and evolution of pathogenic coronaviruses (2019) Nat Rev Microbiol, 17, pp. 181-192; Su, S., Wong, G., Shi, W., Epidemiology, genetic recombination, and pathogenesis of coronaviruses (2016) Trends Microbiol, 24, pp. 490-502; Channappanavar, R., Perlman, S., Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology (2017) Semin Immunopathol, 39, pp. 529-539; Drosten, C., Günther, S., Preiser, W., Identification of a novel coronavirus in patients with severe acute respiratory syndrome (2003) N Engl J Med, 348, pp. 1967-1976; Ksiazek, T.G., Erdman, D., Goldsmith, C.S., A novel coronavirus associated with severe acute respiratory syndrome (2003) N Engl J Med, 348, pp. 1953-1966; (2020), WHO. Middle east respiratory syndrome coronavirus (MERS-CoV); Chan, J.F.-W., Kok, K.-H., Zhu, Z., Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan (2020) Emerg Microbes Infect, 9, pp. 221-236; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506; Wang, R., Zhang, X., Irwin, D.M., Emergence of SARS-like coronavirus poses new challenge in China (2020) J Infect, 80, pp. 350-371; Lu, R., Zhao, X., Li, J., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet, 395, pp. 565-574; Paraskevis, D., Kostaki, E.G., Magiorkinis, G., Full-genome evolutionary analysis of the novel corona virus (2019-nCoV) rejects the hypothesis of emergence as a result of a recent recombination event (2020) Infect Genet Evol, 79; Zhou, P., Yang, X.-L., Wang, X.-G., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature; Zhao, Y., Zhao, Z., Wang, Y., Single-cell rna expression profiling of ACE2, the putative receptor of Wuhan 2019-nCov (2001) bioRxiv 2020: 2020, 2026; Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med; Zhou, P., Yang, X.-L., Wang, X.-G., (2020), Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin. bioRxiv 20202001.2022.914952; D, W., B, H., C, H., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) JAMA; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395, pp. 507-513; Zhang, H., Kang, Z., Gong, H., The digestive system is a potential route of 2019-nCov infection: a bioinformatics analysis based on single-cell transcriptomes (2001) bioRxiv 2020: 2020, 2030; Lu, C.-W., Liu, X.-F., Jia, Z.-F., 2019-nCoV transmission through the ocular surface must not be ignored (2020) Lancet, 395, p. e39; Mahase, E., China coronavirus: what do we know so far? (2020) BMJ, 368, p. m308; Wu, J.T., Leung, K., Leung, G.M., Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study (2020) Lancet, 395, pp. 689-697; Guan, W.J., Ni, Z.Y., Hu, Y., Clinical Characteristics of Coronavirus Disease 2019 in China (2020) N Engl J Med; Michael, D.C., Susan, M.P., Mona, R.L., Severe acute respiratory syndrome (2004) Clin Infect Dis, 38, pp. 1407-1420; Carlos, W.G., Dela Cruz, C.S., Cao, B., Novel wuhan (2019-nCoV) coronavirus (2020) Am J Respir Crit Care Med, 201, pp. P7-P8; Chu, C.M., Cheng, V.C.C., Hung, I.F.N., Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings (2004) Thorax, 59, pp. 252-256; Momattin, H., Al-Ali, A.Y., Al-Tawfiq, J.A., A systematic review of therapeutic agents for the treatment of the Middle East respiratory syndrome coronavirus (MERS-CoV) (2019) Travel Med Infect Dis, 30, pp. 9-18; Xu, Z., Peng, C., Shi, Y., Nelfinavir was predicted to be a potential inhibitor of 2019-nCov main protease by an integrative approach combining homology modelling, molecular docking and binding free energy calculation (2001) bioRxiv 2020: 2020, 2027; Sheahan, T.P., Sims, A.C., Leist, S.R., Comparative therapeutic efficacy of Remdesivir and combination Lopinavir, ritonavir, and interferon beta against MERS-COV (2020) Nat Commun, 11, p. 222; Agostini, M.L., Andres, E.L., Sims, A.C., Coronavirus susceptibility to the antiviral Remdesivir (GS-5734) is mediated by the viral polymerase and the proofreading exoribonuclease (2018) MBio, 9, p. e00221. , pii-218; Wang, M., Cao, R., Zhang, L., Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro (2020) Cell Res, 30, pp. 269-271; Holshue, M.L., DeBolt, C., Lindquist, S., First case of 2019 novel coronavirus in the United States (2020) N Engl J Med, 382, pp. 929-936; Tian, X., Li, C., Huang, A., Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody (2001) bioRxiv 2020: 2020, 2028; Richardson, P., Griffin, I., Tucker, C., Baricitinib as potential treatment for 2019-nCoV acute respiratory disease (2020) Lancet, 395, pp. e30-e31; orneli, H.M., Zorc, J.J., Mahajan, P., A multicenter, randomized, controlled trial of dexamethasone for bronchiolitis (2007) N Engl J Med, 357, pp. 331-339; Ni, Y.N., Chen, G., Sun, J., The effect of corticosteroids on mortality of patients with influenza pneumonia: a systematic review and meta-analysis (2019) Crit Care, 23, p. 99; Clark, D.R., Jonathan, E.M., Baillie, J.K., Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury (2020) Lancet, 395, pp. 473-475; 2Arabi, Y.M., Mandourah, Y., Al-Hameed, F., Corticosteroid therapy for critically ill patients with middle east respiratory syndrome (2018) Am J Respir Crit Care Med, 197, pp. 757-767; Stockman, L.J., Bellamy, R., Garner, P., SARS: systematic review of treatment effects (2006) PLoS Med, 3, p. e343","You, L.; Department of Hematology, the First Affiliated Hospital, College of Medicine, Zhejiang University, 79# Qingchun Road, China; email: youliangshun@zju.edu.cn",,W.B. Saunders Ltd,1634453,,JINFD,32109444,English,J. Infect.,Review,Final,Open Access,Scopus,2-s2.0-85081244162,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Qing E., Gallagher T.",57207584493;7202310503;,SARS Coronavirus Redux,2020,Trends in Immunology,41,4,,271,273,,,10.1016/j.it.2020.02.007,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081906084&doi=10.1016%2fj.it.2020.02.007&partnerID=40&md5=af590f736eb446801b0b22e6040ff1ac,"Department of Microbiology and Immunology, Loyola University Chicago, Maywood, IL 60153, United States","Qing, E., Department of Microbiology and Immunology, Loyola University Chicago, Maywood, IL 60153, United States; Gallagher, T., Department of Microbiology and Immunology, Loyola University Chicago, Maywood, IL 60153, United States","As an atypical pneumonia began to appear in December 2019, Zhou et al. worked with remarkable speed to identify the associated virus, determine its relationship to animal viruses, and evaluate factors conferring infection susceptibility and resistance. These foundational results are being advanced to control the current worldwide human coronavirus epidemic. © 2020 Elsevier Ltd",,,"Zhou, P., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature, 579, pp. 270-273; Menachery, V.D., SARS-like WIV1-CoV poised for human emergence (2016) Proc. Natl. Acad. Sci. U. S. A., 113, pp. 3048-3053; Zhu, N., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N. Engl. J. Med., 382, pp. 727-733; Zou, L., SARS-CoV-2 viral load in upper respiratory specimens of infected patients (2020) N. Engl. J. Med., , Published online February 19, 2020; Li, W., Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2 (2005) EMBO J., 24, pp. 1634-1643; Wan, Y., Receptor recognition by novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS (2020) J. Virol., , Published online January 29, 2020; Wrapp, D., Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation (2020) Science, , Published online February 19, 2020; Park, Y., Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors (2019) Nat. Struct. Mol. Biol., 26, pp. 1151-1157; Belouzard, S., Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites (2009) Proc. Natl. Acad. Sci. U. S. A., 106, pp. 5871-5876; Zhou, Y., Protease inhibitors targeting coronavirus and filovirus entry (2015) Antivir. Res., 116, pp. 76-84","Gallagher, T.; Department of Microbiology and Immunology, Loyola University ChicagoUnited States; email: tgallag@luc.edu",,Elsevier Ltd,14714906,,TIRMA,32173256,English,Trends Immunol.,Short Survey,Final,Open Access,Scopus,2-s2.0-85081906084,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Phan T.,57213171090;,Novel coronavirus: From discovery to clinical diagnostics,2020,"Infection, Genetics and Evolution",79,,104211,,,,3,10.1016/j.meegid.2020.104211,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078734857&doi=10.1016%2fj.meegid.2020.104211&partnerID=40&md5=fabea9d442742860ce36da122403cb03,"Division of Clinical Microbiology, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, United States","Phan, T., Division of Clinical Microbiology, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, United States","A novel coronavirus designated as 2019-nCoV first appeared in Wuhan, China in late December 2019. Dozens of people died in China, and thousands of people infected as 2019-nCoV continues to spread around the world. We have described the discovery, emergence, genomic characteristics, and clinical diagnostics of 2019-nCoV. © 2020 Elsevier B.V.",Bat; China; coronavirus; Pneumonia,"membrane protein; nucleocapsid protein; polyprotein; virus envelope protein; virus spike protein; COVID-19; severe acute respiratory syndrome coronavirus 2; 2019 novel coronavirus; bat; cell culture; China; Coronavirinae; Coronavirus infection; electron microscopy; high throughput sequencing; human; metagenomics; multiplex polymerase chain reaction; nonhuman; Note; nucleic acid amplification; open reading frame; priority journal; real time reverse transcription polymerase chain reaction; SARS coronavirus; sequence analysis; virus genome; virus pneumonia; virus transmission; Betacoronavirus; Coronavirus infection; genetic database; genetics; isolation and purification; virus pneumonia; Betacoronavirus; Coronavirus Infections; Databases, Genetic; Genome, Viral; Humans; Pneumonia, Viral","Babady, N.E., England, M.R., Jurcic Smith, K.L., He, T., Wijetunge, D.S., Tang, Y.W., Chamberland, R.R., Greene, W., Multicenter evaluation of the ePlex respiratory pathogen panel for the detection of viral and bacterial respiratory tract pathogens in nasopharyngeal swabs (2018) J. Clin. Microbiol., 56. , pii: e01658–17; Beckmann, C., Hirsch, H.H., Comparing Luminex NxTAG-respiratory pathogen panel and RespiFinder-22 for multiplex detection of respiratory pathogens (2016) J. Med. Virol., 88, pp. 1319-1324; Fung, T.S., Liu, D.X., Human coronavirus: host-pathogen interaction (2019) Annu. Rev. Microbiol., 73, pp. 529-557; Huang, H.S., Tsai, C.L., Chang, J., Hsu, T.C., Lin, S., Lee, C.C., Multiplex PCR system for the rapid diagnosis of respiratory virus infection: systematic review and meta-analysis (2018) Clin. Microbiol. Infect., 24, pp. 1055-1063; Luk, H.K.H., Li, X., Fung, J., Lau, S.K.P., Woo, P.C.Y., Molecular epidemiology, evolution and phylogeny of SARS coronavirus (2019) Infect. Genet. Evol., pp. 21-30; Ramadan, N., Shaib, H., Middle East respiratory syndrome coronavirus (MERS-CoV): A review (2019) Germs, 9, pp. 35-42; Wong, A.C.P., Li, X., Lau, S.K.P., Woo Viruses, P.C.Y., Global epidemiology of bat coronaviruses (2019), 11. , pii: E174; Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., Zhao, X., Tan, W., China Novel Coronavirus Investigating and Research Team. A novel coronavirus from patients with pneumonia in China, 2019 (2020) N. Engl. J. Med, , Epub ahead of print",,,Elsevier B.V.,15671348,,IGENC,32007627,English,Infec. Genet. Evol.,Note,Final,Open Access,Scopus,2-s2.0-85078734857,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Jiang X., Deng L., Zhu Y., Ji H., Tao L., Liu L., Yang D., Ji W.",57215489750;57215489537;57190050217;57205202219;57215499024;57205199250;57191201473;57206641275;,Psychological crisis intervention during the outbreak period of new coronavirus pneumonia from experience in Shanghai,2020,Psychiatry Research,286,,112903,,,,1,10.1016/j.psychres.2020.112903,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080971403&doi=10.1016%2fj.psychres.2020.112903&partnerID=40&md5=8cc62ce0d42fffe21fc3aab794532a11,"Shanghai Changning Mental Health Center (Affiliated to East China Normal University), Shanghai, 200335, China; Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China; Key Laboratory of Brain Functional Genomics (MOE & STCSM), Shanghai Changning-ECNU Mental Health Center, Institute of Cognitive Neuroscience, School of Psychology and Cognitive Science, East China Normal University, Shanghai, 200062, China","Jiang, X., Shanghai Changning Mental Health Center (Affiliated to East China Normal University), Shanghai, 200335, China; Deng, L., Shanghai Changning Mental Health Center (Affiliated to East China Normal University), Shanghai, 200335, China; Zhu, Y., Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China; Ji, H., Shanghai Changning Mental Health Center (Affiliated to East China Normal University), Shanghai, 200335, China; Tao, L., Key Laboratory of Brain Functional Genomics (MOE & STCSM), Shanghai Changning-ECNU Mental Health Center, Institute of Cognitive Neuroscience, School of Psychology and Cognitive Science, East China Normal University, Shanghai, 200062, China; Liu, L., Shanghai Changning Mental Health Center (Affiliated to East China Normal University), Shanghai, 200335, China; Yang, D., Shanghai Changning Mental Health Center (Affiliated to East China Normal University), Shanghai, 200335, China; Ji, W., Shanghai Changning Mental Health Center (Affiliated to East China Normal University), Shanghai, 200335, China","Since the middle of December 2019, human-to-human transmission of novel coronavirus pneumonia (NCP) has occurred among close contacts. At the same time, greater attention should be paid to psychological crisis intervention (PCI) among affected populations, for the timely prevention of inestimable damage from a secondary psychological crisis. PCI has been initiated via remote (telephone and internet) and onsite medical services to help medical workers, patients, and others affected to overcome any psychological difficulties. This paper outlines experiences based on the work of the Shanghai Medical Team. © 2020 Elsevier B.V.",Crisis intervention; New coronavirus pneumonia,Article; China; consultation; Coronavirus infection; crisis intervention; emergency medical dispatch; high risk population; human; impulsiveness; internet consultation; mental health care; novel coronavirus pneumonia; patient counseling; practice guideline; priority journal; psychotrauma; public-private partnership; risk reduction; suicide; teleconsultation; virus pneumonia,"Chen, X.Y., Chen, J., Shi, X., Jiang, M., Li, Y., Zhou, Y., Ran, M., Chan, C.L.W., Trajectories of maternal symptoms of posttraumatic stress disorder predict long-term mental health of children following the Wenchuan earthquake in China: a 10-year follow-up study (2020) J. Affect. Disord., 266, pp. 201-206; Expert consensus on managing pathway and coping strategies for patients with mental disorders during prevention and control of serious and outbreak infectious diseases (novel coronavirus pneumonia) (2020) Chin. J. Psychiatry, 53, p. E002; Jiang, W., Hou, G., Li, J., Peng, C., Wang, S., Liu, S., Zhuang, Q., Liu, H., Prevalence of H7N9 subtype avian influenza viruses in poultry in China, 2013-2018 (2019) Transbound. Emerg. Dis., 66 (4), pp. 1758-1761; Lau, J.T., Yang, X., Tsui, H.Y., Pang, E., Wing, Y.K., Positive mental health-related impacts of the SARS epidemic on the general public in Hong Kong and their associations with other negative impacts (2006) J. Infect., 53 (2), pp. 114-124; Ma, N., Ma, H., Li, L., Reading and analysis of the guiding principles of emergent psychological crisis intervention in the novel coronavirusd pneumonia (2020) Chin. J. Psychiatry, 53, p. E001; Mak, I.W., Chu, C.M., Pan, P.C., Yiu, M.G., Ho, S.C., Chan, V.L., Risk factors for chronic post-traumatic stress disorder (PTSD) in sars survivors (2010) Gen. Hosp. Psychiatry, 32 (6), pp. 590-598; Peng, E.Y., Lee, M.B., Tsai, S.T., Yang, C.C., Morisky, D.E., Tsai, L.T., Weng, Y.L., Lyu, S.Y., Population-based post-crisis psychological distress: an example from the SARS outbreak in Taiwan (2010) J. Formos. Med. Assoc., 109 (7), pp. 524-532; Zhu, Y., Chen, L., Ji, H., Xi, M., Fang, Y., Li, Y., The risk and prevention of novel coronavirus pneumonia infections among inpatients in psychiatric hospitals (2020) Neurosc. Bullet..","Zhu, Y.; Shanghai Mental Health Center, Shanghai Jiao Tong University School of MedicineChina; email: hellfiregenius@163.com",,Elsevier Ireland Ltd,1651781,,PSRSD,32146245,English,Psychiatry Res.,Article,Final,Open Access,Scopus,2-s2.0-85080971403,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Coutard B., Valle C., de Lamballerie X., Canard B., Seidah N.G., Decroly E.",6504789960;57205098838;7006347976;7003995150;55521874200;6603700686;,The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade,2020,Antiviral Research,176,,104742,,,,4,10.1016/j.antiviral.2020.104742,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079394767&doi=10.1016%2fj.antiviral.2020.104742&partnerID=40&md5=30d4c75a66de468a80eb0394754d70a1,"Unité des Virus Émergents (UVE: Aix-Marseille Univ – IRD 190 – Inserm 1207 – IHU Méditerranée Infection), Marseille, France; Aix Marseille Université, CNRS, AFMB UMR 7257, Marseille, France; Laboratory of Biochemical Neuroendocrinology, Montreal Clinical Research Institute (IRCM, Affiliated to the University of Montreal), 110 Pine Ave West, Montreal, QC H2W1R7, Canada","Coutard, B., Unité des Virus Émergents (UVE: Aix-Marseille Univ – IRD 190 – Inserm 1207 – IHU Méditerranée Infection), Marseille, France; Valle, C., Aix Marseille Université, CNRS, AFMB UMR 7257, Marseille, France; de Lamballerie, X., Unité des Virus Émergents (UVE: Aix-Marseille Univ – IRD 190 – Inserm 1207 – IHU Méditerranée Infection), Marseille, France; Canard, B., Aix Marseille Université, CNRS, AFMB UMR 7257, Marseille, France; Seidah, N.G., Laboratory of Biochemical Neuroendocrinology, Montreal Clinical Research Institute (IRCM, Affiliated to the University of Montreal), 110 Pine Ave West, Montreal, QC H2W1R7, Canada; Decroly, E., Aix Marseille Université, CNRS, AFMB UMR 7257, Marseille, France","In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs. In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals. © 2020 Elsevier B.V.",2019-nCoV; Antivirals; Furin; Maturation protease; SARS-CoV; Spike protein,"furin; virus envelope protein; virus fusion protein; virus glycoprotein; virus hemagglutinin; vitronectin; coronavirus spike glycoprotein; furin; severe acute respiratory syndrome coronavirus 2; 2019 novel coronavirus; Article; cladistics; Coronavirinae; nonhuman; pathogenicity; priority journal; protein cleavage; SARS coronavirus; virus genome; virus particle; amino acid sequence; Betacoronavirus; chemistry; protein conformation; Amino Acid Sequence; Betacoronavirus; Furin; Genome, Viral; Protein Conformation; Spike Glycoprotein, Coronavirus","Anderson, E.D., Thomas, L., Hayflick, J.S., Thomas, G., Inhibition of HIV-1 gp160-dependent membrane fusion by a furin-directed α1-antitrypsin variant (1993) J. Biol. Chem., 268, pp. 24887-24891; Bassi, D.E., Zhang, J., Renner, C., Klein-Szanto, A.J., Targeting proprotein convertases in furin-rich lung cancer cells results in decreased in vitro and in vivo growth (2017) Mol. Carcinog., 56, pp. 1182-1188; Bosch, B.J., Bartelink, W., Rottier, P.J.M., Cathepsin L functionally cleaves the severe acute respiratory syndrome coronavirus class I fusion protein upstream of rather than adjacent to the fusion peptide (2008) J. Virol., 82, pp. 8887-8890; Braun, E., Sauter, D., Furin-mediated protein processing in infectious diseases and cancer (2019) Clin. Transl. Immunol., 8, p. e1073; Chan, C.M., Woo, P.C., Lau, S.K., Tse, H., Chen, H.L., Li, F., Zheng, B.J., Yuen, K.Y., Spike protein, S, of human coronavirus HKU1: role in viral life cycle and application in antibody detection (2008) Exp. Biol. 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Acta Protein Proteonomics; Kim, W., Zekas, E., Lodge, R., Susan-Resiga, D., Marcinkiewicz, E., Essalmani, R., Mihara, K., Seidah, N.G., Neuroinflammation-Induced interactions between protease-activated receptor 1 and proprotein convertases in HIV-associated neurocognitive disorder (2015) Mol. Cell Biol., 35, pp. 3684-3700; Kuhn, J.H., Li, W., Choe, H., Farzan, M., Angiotensin-converting enzyme 2: a functional receptor for SARS coronavirus (2004) Cell. Mol. 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NEJMoa2001316; Li, W., Moore, M.J., Vasllieva, N., Sui, J., Wong, S.K., Berne, M.A., Somasundaran, M., Farzan, M., Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus (2003) Nature, 426, pp. 450-454; Lu, G., Wang, Q., Gao, G.F., Bat-to-human: spike features determining “host jump” of coronaviruses SARS-CoV, MERS-CoV, and beyond (2015) Trends Microbiol.; Matsuyama, S., Nagata, N., Shirato, K., Kawase, M., Takeda, M., Taguchi, F., Efficient activation of the severe acute respiratory syndrome coronavirus spike protein by the transmembrane protease TMPRSS2 (2010) J. Virol., 84, pp. 12658-12664; Matsuyama, S., Ujike, M., Morikawa, S., Tashiro, M., Taguchi, F., Protease-mediated enhancement of severe acute respiratory syndrome coronavirus infection (2005) Proc. Natl. Acad. Sci. 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Virol.; Yuan, Y., Cao, D., Zhang, Y., Ma, J., Qi, J., Wang, Q., Lu, G., Gao, G.F., Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains (2017) Nat. Commun.; Zhao, S., Ran, J., Musa, S.S., Yang, G., Wang, W., Lou, Y., Gao, D., Wang, M.H., Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: a data-driven analysis in the early phase of the outbreak (2020) Int J Infect Dis, pp. 30053-30059","Decroly, E.; Aix Marseille Université, CNRS, AFMB UMR 7257, France; email: etienne.decroly@afmb.univ-mrs.fr",,Elsevier B.V.,1663542,,ARSRD,32057769,English,Antiviral Res.,Article,Final,Open Access,Scopus,2-s2.0-85079394767,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Chen Y., Liu Q., Guo D.",56399209300;57212729985;57203942550;,"Emerging coronaviruses: Genome structure, replication, and pathogenesis",2020,Journal of Medical Virology,92,4,,418,423,,32,10.1002/jmv.25681,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078856946&doi=10.1002%2fjmv.25681&partnerID=40&md5=2962270fe25bb245787246b1fde31cd2,"State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, China; Center for Infection and Immunity Study, School of Medicine, Sun Yat-sen University, Guangzhou, China","Chen, Y., State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, China; Liu, Q., State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, China; Guo, D., Center for Infection and Immunity Study, School of Medicine, Sun Yat-sen University, Guangzhou, China","The recent emergence of a novel coronavirus (2019-nCoV), which is causing an outbreak of unusual viral pneumonia in patients in Wuhan, a central city in China, is another warning of the risk of CoVs posed to public health. In this minireview, we provide a brief introduction of the general features of CoVs and describe diseases caused by different CoVs in humans and animals. This review will help understand the biology and potential risk of CoVs that exist in richness in wildlife such as bats. © 2020 Wiley Periodicals, Inc.",coronavirus; epidemiology; pathogenesis; respiratory tract; virus classification; zoonoses,"recombinant interferon; ribavirin; viral protein; COVID-19; severe acute respiratory syndrome coronavirus 2; viral protein; 2019 novel Coronavirus; China; Coronavirinae; coronavirus disease 2019; Coronavirus infection; gene replication; gene structure; human; infection risk; nonhuman; pathogenesis; protein function; protein structure; public health; Review; virus pneumonia; wildlife; animal; Betacoronavirus; communicable disease; Coronavirinae; Coronavirus infection; genetics; host range; pathogenicity; physiology; veterinary medicine; virology; virus genome; virus replication; Animals; Betacoronavirus; Communicable Diseases, Emerging; Coronavirus; Coronavirus Infections; Genome, Viral; Host Specificity; Humans; Pneumonia, Viral; Viral Nonstructural Proteins; 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State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan UniversityChina; email: chenyu@whu.edu.cn",,John Wiley and Sons Inc.,1466615,,JMVID,31967327,English,J. Med. Virol.,Review,Final,Open Access,Scopus,2-s2.0-85078856946,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Sohrabi C., Alsafi Z., O'Neill N., Khan M., Kerwan A., Al-Jabir A., Iosifidis C., Agha R.",57210337178;56336894700;57216008546;57215504246;57193272966;57196036866;57211645688;57216026175;,World Health Organization declares global emergency: A review of the 2019 novel coronavirus (COVID-19),2020,International Journal of Surgery,76,,,71,76,,2,10.1016/j.ijsu.2020.02.034,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080988227&doi=10.1016%2fj.ijsu.2020.02.034&partnerID=40&md5=6f14615e718590d1168d9cc25772fa3f,"Barts and The London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom; UCL Medical School, University College London, United Kingdom; GKT School of Medical Education, King's College London, United Kingdom; Barts Health NHS Trust, London, United Kingdom","Sohrabi, C., Barts and The London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom; Alsafi, Z., UCL Medical School, University College London, United Kingdom; O'Neill, N., Barts and The London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom; Khan, M., UCL Medical School, University College London, United Kingdom; Kerwan, A., GKT School of Medical Education, King's College London, United Kingdom; Al-Jabir, A., GKT School of Medical Education, King's College London, United Kingdom; Iosifidis, C., Barts and The London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom; Agha, R., Barts Health NHS Trust, London, United Kingdom","An unprecedented outbreak of pneumonia of unknown aetiology in Wuhan City, Hubei province in China emerged in December 2019. A novel coronavirus was identified as the causative agent and was subsequently termed COVID-19 by the World Health Organization (WHO). Considered a relative of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS), COVID-19 is caused by a betacoronavirus named SARS-CoV-2 that affects the lower respiratory tract and manifests as pneumonia in humans. Despite rigorous global containment and quarantine efforts, the incidence of COVID-19 continues to rise, with 90,870 laboratory-confirmed cases and over 3,000 deaths worldwide. In response to this global outbreak, we summarise the current state of knowledge surrounding COVID-19. © 2020 IJS Publishing Group Ltd",COVID-19; Global health emergency; Novel coronavirus; Viral transmission; Wuhan,Coronavirinae; human; incidence; major clinical study; nonhuman; quarantine; review; virus transmission; World Health Organization,"Lu, H., Stratton, C.W., Tang, Y., Outbreak of pneumonia of unknown etiology in wuhan China: the mystery and the miracle (2020) J. Med. Virol., p. 25678; World Health Organization, WHO Director-General's Remarks at the Media Briefing on 2019-nCoV on 11 February 2020 (2020), https://www.who.int/dg/speeches/detail/who-director-general-s-remarks-at-the-media-briefing-on-2019-ncov-on-11-february-2020; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet; Wang, D., Hu, B., Hu, C., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in wuhan, China (2020) J. Am. Med. 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Epub ahead of print; Røsjø, H., Varpula, M., Hagve, T.-A., Karlsson, S., Ruokonen, E., Pettilä, V., Omland, T., Circulating high sensitivity troponin T in severe sepsis and septic shock: distribution, associated factors, and relation to outcome (2011) Intensive Care Med., 37, pp. 77-85; World Health Organization, Pocket Book of Hospital Care for Children: Guidelines for the Management of Common Childhood Illnesses (2013); World Health Organization, WHO Global Epidemiological Surveillance Standards for Influenza (2014); Schultz, M.J., Dunser, M.W., Dondorp, A.M., Current challenges in the management of sepsis in ICUs in resource-poor settings and suggestions for the future (2017) Intensive Care Med., 43, pp. 612-624; Rhodes, A., Evans, L.E., Alhazzani, W., Surviving sepsis campaign: international guidelines for management of sepsis and septic shock (2017) Intensive Care Med., 43, pp. 304-377. , 2016; Kui, L., Fang, Y.-Y., Deng, Y., Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province (2020) Chin. Med. J. (Engl), 1; Chu, C.M., Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings (2004) Thorax, 59, pp. 252-256; World Health Organization, Summary of Probable SARS Cases with Onset of Illness from 1 November 2002 to 31 (2003), https://www.who.int/csr/sars/country/table2003_09_23/en/, July 2003; World Health Organization, Middle East respiratory syndrome coronavirus (MERS-CoV) (2019), https://www.who.int/emergencies/mers-cov/en/; Wang, W., Tang, J., Wei, F., Updated understanding of the outbreak of 2019 novel coronavirus (2019‐nCoV) in Wuhan, China (2020) J. Med. Virol., p. 25689; Oh, M., Park, W.B., Park, S.-W., Choe, P.G., Bang, J.H., Song, K.-H., Kim, E.S., Kim, N.J., Middle East respiratory syndrome: what we learned from the 2015 outbreak in the Republic of Korea (2018) Korean J. Intern. Med., 33, pp. 233-246; Hui, D.S.-C., Wong, P.-C., Wang, C., SARS: clinical features and diagnosis (2003) Respirology, 8, pp. S20-S24; Chinese Coronavirus Infections, Death Toll Soar as Fifth Case Is Confirmed in U.S (2020), https://www.washingtonpost.com/gdpr-consent/?destination=%2Fworld%2Fasia_pacific%2Fcoronavirus-china-latest-updates%2F2020%2F01%2F26%2F4603266c-3fa8-11ea-afe2-090eb37b60b1_story.html%3F; The Guardian, Hong Kong Cuts China Transport Links as Coronavirus Toll Mounts (2020), https://www.theguardian.com/science/2020/jan/28/wuhan-evacuation-us-and-japan-to-fly-out-citizens-as-coronavirus-deaths-rise; The New York Times, Coronavirus in New York: Lunar New Year Events Canceled over Fears (2020), https://www.nytimes.com/2020/01/29/nyregion/coronavirus-nyc.html; Madhav, N., Oppenheim, B., Gallivan, M., Mulembakani, P., Rubin, E., Wolfe, N., Pandemics: risks, impacts, and mitigation (2017) Dis. Control Priorities Improv. Heal. Reducing Poverty; World Health Organization, Statement on the Second Meeting of the International Health Regulations (2005) Emergency Committee Regarding the Outbreak of Novel Coronavirus (2019-nCoV) (2020), https://www.who.int/news-room/detail/30-01-2020-statement-on-the-second-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-outbreak-of-novel-coronavirus-(2019-ncov); The Guardian, New 1,000-bed Wuhan Hospital Takes its First Coronavirus Patients (2020), https://www.theguardian.com/world/2020/feb/04/new-1000-bed-wuhan-hospital-takes-its-first-coronavirus-patients; Italy Suspends Visa Issuance and All Air Traffic from China (2020), https://www.schengenvisainfo.com/news/italy-suspends-visa-issuance-and-all-air-traffic-from-china/; U.S. Imposes Entry Restrictions over Coronavirus (2020), https://www.wsj.com/articles/u-k-reports-first-coronavirus-cases-as-china-allies-limit-ties-11580467046; Phelan, A.L., Katz, R., Gostin, L.O., The novel coronavirus originating in wuhan, China (2020) J. Am. Med. Assoc.; BBC, Coronavirus: which countries have evacuated their citizens? (2020), https://www.bbc.co.uk/news/world-asia-china-51312378; BBC, Coronavirus: More Britons Evacuated from Wuhan on French Flight (2020), https://www.bbc.co.uk/news/health-51345279; U.S. Plans to Evacuate More Americans by Aircraft from Wuhan (2020), https://www.wsj.com/articles/u-s-plans-another-wuhan-evacuation-flight-as-soon-as-next-week-11580380747; Lu, R., Zhao, X., Li, J., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet; Fehr, A.R., Perlman, S., Coronaviruses: an Overview of Their Replication and Pathogenesis (2015), pp. 1-23; The Harvard Gazette, Coronavirus Cases Hit 17,400 and Are Likely to Surge (2020), https://news.harvard.edu/gazette/story/2020/02/as-confirmed-cases-of-coronavirus-surge-path-grows-uncertain/; Bloomberg Businessweek, Coronavirus Is More Dangerous for the Global Economy than SARS (2020), https://www.bloomberg.com/news/articles/2020-01-31/the-coronavirus-is-more-dangerous-for-the-economy-than-sars; Reuters, Instant View: China's Economic Growth Slows to 6.1% in 2019, Near 30-year Low (2020), https://www.reuters.com/article/us-china-economy-gdp-instantview/instant-view-chinas-economic-growth-slows-to-6-1-in-2019-near-30-year-low-idUSKBN1ZG092; As Wuhan Coronavirus Drags on Chinese Markets, the World Economy Braces for a Slowdown (2020), https://time.com/5775027/wuhan-coronavirus-global-economy/; Brookings, Global Manufacturing Scorecard: How the US Compares to 18 Other Nations (2018), https://www.brookings.edu/research/global-manufacturing-scorecard-how-the-us-compares-to-18-other-nations/; Bloomberg, China's Oil Imports Are Most World's Ever Seen and Still Growing (2019), https://www.bloomberg.com/news/articles/2019-12-17/china-s-oil-imports-are-most-world-s-ever-seen-and-still-growing; Financial Times, (2020), https://www.ft.com/content/3da73290-5067-11ea-8841-482eed0038b1, China's Xi Jinping knew of coronavirus earlier than first thought","O'Neill, N.; Barts and The London School of Medicine and Dentistry, Queen Mary University of LondonUnited Kingdom; email: niamh@ijspg.com",,Elsevier Ltd,17439191,,,32112977,English,Int. J. Surg.,Review,Final,Open Access,Scopus,2-s2.0-85080988227,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Lin Q., Zhao S., Gao D., Lou Y., Yang S., Musa S.S., Wang M.H., Cai Y., Wang W., Yang L., He D.",56902109600;57194229769;38861547100;16417276600;57215495176;57207792527;55596673500;37032494700;57204925889;57105980700;7403045834;,"A conceptual model for the coronavirus disease 2019 (COVID-19) outbreak in Wuhan, China with individual reaction and governmental action",2020,International Journal of Infectious Diseases,93,,,211,216,,,10.1016/j.ijid.2020.02.058,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081029824&doi=10.1016%2fj.ijid.2020.02.058&partnerID=40&md5=479f83251826f8172beb1fc473c3a774,"Michigan Institute for Data Science, University of Michigan, Ann Arbor, MI, United States; JC School of Public Health and Primary Care, Chinese University of Hong Kong, Hong Kong, Hong Kong; Shenzhen Research Institute of Chinese University of Hong Kong, Shenzhen, China; Mathematics and Science College, Shanghai Normal University, Shanghai, China; Department of Applied Mathematics, Hong Kong Polytechnic University, Hong Kong, Hong Kong; College of Medical Information Engineering, Chengdu University of Traditional Chinese Medicine, Chengdu, China; School of Mathematics and Statistics, Huaiyin Normal University, Huai'an, China; School of Nursing, Hong Kong Polytechnic University, Hong Kong, Hong Kong","Lin, Q., Michigan Institute for Data Science, University of Michigan, Ann Arbor, MI, United States; Zhao, S., JC School of Public Health and Primary Care, Chinese University of Hong Kong, Hong Kong, Hong Kong, Shenzhen Research Institute of Chinese University of Hong Kong, Shenzhen, China; Gao, D., Mathematics and Science College, Shanghai Normal University, Shanghai, China; Lou, Y., Department of Applied Mathematics, Hong Kong Polytechnic University, Hong Kong, Hong Kong; Yang, S., College of Medical Information Engineering, Chengdu University of Traditional Chinese Medicine, Chengdu, China; Musa, S.S., Department of Applied Mathematics, Hong Kong Polytechnic University, Hong Kong, Hong Kong; Wang, M.H., JC School of Public Health and Primary Care, Chinese University of Hong Kong, Hong Kong, Hong Kong, Shenzhen Research Institute of Chinese University of Hong Kong, Shenzhen, China; Cai, Y., School of Mathematics and Statistics, Huaiyin Normal University, Huai'an, China; Wang, W., School of Mathematics and Statistics, Huaiyin Normal University, Huai'an, China; Yang, L., School of Nursing, Hong Kong Polytechnic University, Hong Kong, Hong Kong; He, D., Department of Applied Mathematics, Hong Kong Polytechnic University, Hong Kong, Hong Kong","The ongoing coronavirus disease 2019 (COVID-19) outbreak, emerged in Wuhan, China in the end of 2019, has claimed more than 2600 lives as of 24 February 2020 and posed a huge threat to global public health. The Chinese government has implemented control measures including setting up special hospitals and travel restriction to mitigate the spread. We propose conceptual models for the COVID-19 outbreak in Wuhan with the consideration of individual behavioural reaction and governmental actions, e.g., holiday extension, travel restriction, hospitalisation and quarantine. We employe the estimates of these two key components from the 1918 influenza pandemic in London, United Kingdom, incorporated zoonotic introductions and the emigration, and then compute future trends and the reporting ratio. The model is concise in structure, and it successfully captures the course of the COVID-19 outbreak, and thus sheds light on understanding the trends of the outbreak. © 2020",City lockdown; COVID-19; Epidemic; Governmental action; Individual reaction; Mathematical modelling,2019 novel coronavirus; Article; behavior; China; conceptual model; Coronavirinae; Coronavirus infection; disease transmission; epidemic; government; hospitalization; human; infection control; infection risk; pandemic; population size; public health; quarantine; simulation; travel,"Bogoch II, Watts, A., Thomas-Bachli, A., Huber, C., Kraemer, M.U.G., Khan, K., Pneumonia of unknown etiology in Wuhan, China: potential for international spread via commercial air travel (2020) J Travel Med; Guan, W., Ni, Z., Hu, Y., Liang, W., Ou, C., He, J., Clinical characteristics of 2019 novel coronavirus infection in China (2020) NEJM; He, D., Dushoff, J., Day, T., Ma, J., Earn, D.J., Inferring the causes of the three waves of the 1918 influenza pandemic in England and Wales (2013) Proc R Soc B: Biol Sci, 280 (1766), p. 20131345; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet; Imai, N., Cori, A., Dorigatti, I., Baguelin, M., Donnelly, C.A., Riley, S., Report 3: transmissibility of 2019-nCoV (2020), https://www.imperial.ac.uk/media/imperial-college/medicine/sph/ide/gida-fellowships/Imperial-2019-nCoV-transmissibility.pdf, British Medical Journal Publishing Group; Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Early transmission dynamics in Wuhan, China, of novel Coronavirus–infected pneumonia (2020) N Engl J Med; Li, R., Pei, S., Chen, B., Song, Y., Zhang, T., Yang, W., Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (COVID-19) (2020) medRxiv, , https://www.medrxiv.org/content/early/2020/02/17/2020.02.14.20023127, Available from:; Liu, T., Hu, J., Kang, M., Lin, L., Zhong, H., Xiao, J., Transmission dynamics of 2019 novel coronavirus (2019-nCoV) (2020) bioRxiv; Mahase, E., Coronavirus: UK screens direct flights from Wuhan after US case (2020), British Medical Journal Publishing Group; The Novel Coronavirus Pneumonia Emergency Response Epidemiology Team, The novel Coronavirus pneumonia emergency response epidemiology team (2020) Chin J Epidemiol, 41 (2), pp. 145-151; National Health Commission of the People's Republic of China, The updated news of COVID-19 as of 24 February 2020 (2020), http://www.nhc.gov.cn/yjb/s7860/202002/67e6c59a84bd4f07b6ca4a4c5ffabb79.shtml, 24:00;. Online; (accessed 25.02.20); Nishiura, H., Kobayashi, T., Yang, Y., Hayashi, K., Miyama, T., Kinoshita, R., The rate of underascertainment of novel Coronavirus (2019-nCoV) infection: estimation using Japanese passengers data on evacuation flights (2020) J Clin Med, 9 (2). , https://www.mdpi.com/2077-0383/9/2/419, Available from:; Nishiura, H., Linton, N.M., Akhmetzhanov, A.R., Serial interval of novel coronavirus (2019-nCoV) infections (2020) medRxiv; Riou, J., Althaus, C.L., Pattern of early human-to-human transmission of Wuhan 2019 novel coronavirus (2019-nCoV), December 2019 to January 2020 (2020) Eurosurveillance, 25 (4); South China Morning Post, 5 million left Wuhan before lockdown, 1000 new coronavirus cases expected in city; (2020), https://www.scmp.com/news/china/society/article/3047720/chinese-premier-li-keqiang-head-coronavirus-crisis-team-outbreak, Online; (accessed 26.01.20); Tuite, A.R., Fisman, D.N., Reporting, epidemic growth, and reproduction numbers for the 2019 novel Coronavirus (2019-nCoV) epidemic (2020) Ann Intern Med; van den Driessche, P., Watmough, J., Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission (2002) Math Biosci, 180 (1), pp. 29-48. , http://www.sciencedirect.com/science/article/pii/S0025556402001086, Available from:; Worldometers, Coronavirus cases (2020), https://www.worldometers.info/coronavirus/coronavirus-cases, Online; / (accessed 26.02.20.); Wu, Z., McGoogan, J.M., Characteristics of and important lessons from the Coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72,314 cases from the Chinese center for disease control and prevention (2020) JAMA; Wu, J.T., Leung, K., Leung, G.M., Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study (2020) Lancet, , http://www.sciencedirect.com/science/article/pii/S1201971220300539, Available from:; Wu, P., Hao, X., Lau, E.H.Y., Wong, J.Y., Leung, K.S.M., Wu, J.T., Real-time tentative assessment of the epidemiological characteristics of novel coronavirus infections in Wuhan, China, as at 22 January 2020 (2020) Eurosurveillance, p. 25; You, C., Deng, Y., Hu, W., Sun, J., Lin, Q., Zhou, F., Estimation of the time-varying reproduction number of COVID-19 outbreak in China (2020) medRxiv, , https://www.medrxiv.org/content/early/2020/02/17/2020.02.08.20021253, Available from:; Zhao, S., Musa, S.S., Lin, Q., Ran, J., Yang, G., Wang, W., Estimating the unreported number of novel Coronavirus (2019-nCoV) cases in China in the first half of January 2020: a data-driven modelling analysis of the early outbreak (2020) J Clin Med, 9 (2). , https://www.mdpi.com/2077-0383/9/2/388, Available from:; Zhao, S., Lin, Q., Ran, J., Musa, S.S., Yang, G., Wang, W., Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: a data-driven analysis in the early phase of the outbreak (2020) Int J Infect Dis, 92, pp. 214-217. , http://www.sciencedirect.com/science/article/pii/S1201971220300539, Available from:; Zhao, S., Gao, D., Zhuang, Z., Chong, M., Cai, Y., Ran, J., Estimating the serial interval of the novel coronavirus disease (COVID-19): a statistical analysis using the public data in Hong Kong from January 16 to February 15, 2020 (2020) medRxiv","Wang, W.; School of Mathematics and Statistics, Huaiyin Normal UniversityChina; email: weimingwang2003@163.com",,Elsevier B.V.,12019712,,IJIDF,32145465,English,Int. J. Infect. Dis.,Article,Final,Open Access,Scopus,2-s2.0-85081029824,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Xie C., Jiang L., Huang G., Pu H., Gong B., Lin H., Ma S., Chen X., Long B., Si G., Yu H., Jiang L., Yang X., Shi Y., Yang Z.",55375871900;57215771542;57215773005;7102807084;26644056300;57215778342;36135898200;57215776570;57215775038;57215777834;57215780239;57215771969;57215778429;56486347700;57198698720;,Comparison of different samples for 2019 novel coronavirus detection by nucleic acid amplification tests,2020,International Journal of Infectious Diseases,93,,,264,267,,,10.1016/j.ijid.2020.02.050,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081885759&doi=10.1016%2fj.ijid.2020.02.050&partnerID=40&md5=6af9593c1b99d944950c48b7d1139491,"Sichuan Provincial Key Laboratory for Human Disease Gene Study and Institute of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China; Department of Radiology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China; Institute of Biology, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, Sichuan, China; Department of Infectious Disease, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China; Department of Infectious Disease, Sichuan Mianyang 404 Hospital, Mianyang, China; Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences (2019RU026), Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan, China","Xie, C., Sichuan Provincial Key Laboratory for Human Disease Gene Study and Institute of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China; Jiang, L., Sichuan Provincial Key Laboratory for Human Disease Gene Study and Institute of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China; Huang, G., Sichuan Provincial Key Laboratory for Human Disease Gene Study and Institute of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China; Pu, H., Department of Radiology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China; Gong, B., Sichuan Provincial Key Laboratory for Human Disease Gene Study and Institute of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China, Institute of Biology, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, Sichuan, China; Lin, H., Sichuan Provincial Key Laboratory for Human Disease Gene Study and Institute of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China; Ma, S., Sichuan Provincial Key Laboratory for Human Disease Gene Study and Institute of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China; Chen, X., Department of Infectious Disease, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China; Long, B., Department of Infectious Disease, Sichuan Mianyang 404 Hospital, Mianyang, China; Si, G., Department of Infectious Disease, Sichuan Mianyang 404 Hospital, Mianyang, China; Yu, H., Sichuan Provincial Key Laboratory for Human Disease Gene Study and Institute of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China; Jiang, L., Sichuan Provincial Key Laboratory for Human Disease Gene Study and Institute of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China; Yang, X., Department of Infectious Disease, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China; Shi, Y., Sichuan Provincial Key Laboratory for Human Disease Gene Study and Institute of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China, Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences (2019RU026), Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan, China; Yang, Z., Sichuan Provincial Key Laboratory for Human Disease Gene Study and Institute of Laboratory Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China, Institute of Biology, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, Sichuan, China, Research Unit for Blindness Prevention of Chinese Academy of Medical Sciences (2019RU026), Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan, China","An ongoing outbreak of severe respiratory pneumonia associated with the 2019 novel coronavirus has recently emerged in China. Here we report the epidemiological, clinical, laboratory and radiological characteristics of 19 suspect cases. We compared the positive ratio of 2019-nCoV nucleic acid amplification test results from different samples including oropharyngeal swab, blood, urine and stool with 3 different fluorescent RT-PCR kits. Nine out of the 19 patients had 2019-nCoV infection detected using oropharyngeal swab samples, and the virus nucleic acid was also detected in eight of these nine patients using stool samples. None of positive results was identified in the blood and urine samples. These three different kits got the same result for each sample and the positive ratio of nucleic acid detection for 2019-nCoV was only 47.4% in the suspect patients. Therefore, it is possible that infected patients have been missed by using nucleic acid detection only. It might be better to make a diagnosis combining the computed tomography scans and nucleic acid detection. © 2020 University of Electronic Science and Technology of China, Chengdu, China",2019 Novel coronavirus pneumonia; Clinical diagnosis; Nucleic acid amplification test,C reactive protein; fibrinogen; nucleic acid; urea; virus RNA; activated partial thromboplastin time; Adenoviridae; adult; Article; blood sampling; child; clinical article; comparative study; computer assisted tomography; controlled study; coronavirus disease 2019; Coronavirus infection; coughing; diarrhea; false negative result; fatigue; feces analysis; female; fever; fibrinogen blood level; fluorescence quantitative polymerase chain reaction; hematocrit; human; Human respiratory syncytial virus; Influenza A virus; Influenza B virus; lymphocyte count; male; middle aged; nucleic acid amplification; nucleic acid analysis; oropharynx; Paramyxovirinae; Rhinovirus; RNA extraction; SARS coronavirus; school child; Severe acute respiratory syndrome coronavirus 2; throat culture; urea blood level; urine sampling; virus detection; young adult,"Cui, J., Li, F., Shi, Z.L., Origin and evolution of pathogenic coronaviruses (2019) Nat Rev Microbiol, 17 (3), pp. 181-192; Drosten, C., Gunther, S., Preiser, W., van der Werf, S., Brodt, H.R., Becker, S., Identification of a novel coronavirus in patients with severe acute respiratory syndrome (2003) N Engl J Med, 348 (20), pp. 1967-1976; Fouchier, R.A., Kuiken, T., Schutten, M., van Amerongen, G., van Doornum, G.J., van den Hoogen, B.G., Aetiology: Koch's postulates fulfilled for SARS virus (2003) Nature, 423 (6937), p. 240; To, K.K.W., Yip, C.C.Y., Lai, C.Y.W., Wong, C.K.H., Ho, D.T.Y., Pang, P.K.P., Saliva as a diagnostic specimen for testing respiratory virus by a point-of-care molecular assay: a diagnostic validity study (2019) Clin Microbiol Infect, 25 (3), pp. 372-378; Wang, C., Horby, P.W., Hayden, F.G., Gao, G.F., A novel coronavirus outbreak of global health concern (2020) Lancet, 395 (10223), pp. 470-473; Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) JAMA; Woo, P.C., Lau, S.K., Lam, C.S., Lau, C.C., Tsang, A.K., Lau, J.H., Discovery of seven novel mammalian and avian coronaviruses in the genus deltacoronavirus supports bat coronaviruses as the gene source of alphacoronavirus and betacoronavirus and avian coronaviruses as the gene source of gammacoronavirus and deltacoronavirus (2012) J Virol, 86 (7), pp. 3995-4008; Wu, F., Zhao, S., Yu, B., Chen, Y.M., Wang, W., Song, Z.G., A new coronavirus associated with human respiratory disease in China (2020) Nature, 579 (7798), pp. 265-269; Zhong, N.S., Zheng, B.J., Li, Y.M., Poon, Xie, Z.H., Chan, K.H., Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China, in February, 2003 (2003) Lancet, 362 (9393), pp. 1353-1358; Zhou, P., Yang, X.L., Wang, X.G., Hu, B., Zhang, L., Zhang, W., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature, 579 (7798), pp. 270-273","Yang, X.; Sichuan Provincial Key Laboratory for Human Disease Gene Study, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, 32 The First Ring Road West 2, China; email: 350686908@qq.com",,Elsevier B.V.,12019712,,IJIDF,32114193,English,Int. J. Infect. Dis.,Article,Final,Open Access,Scopus,2-s2.0-85081885759,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Mattei D.N., Kopper J.J., Sanz M.G.",57214077124;24474881300;14011847900;,Equine Coronavirus-Associated Colitis in Horses: A Retrospective Study,2020,Journal of Equine Veterinary Science,87,,102906,,,,,10.1016/j.jevs.2019.102906,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078214592&doi=10.1016%2fj.jevs.2019.102906&partnerID=40&md5=bf91d4cdd8a26044d3e825bdfc11a1b8,"Equine Veterinary Medical Center, Member of Qatar Foundation, Doha, Qatar; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA, United States","Mattei, D.N., Equine Veterinary Medical Center, Member of Qatar Foundation, Doha, Qatar; Kopper, J.J., Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA, United States; Sanz, M.G., Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA, United States","Equine coronavirus (ECoV) is a known cause of fever, anorexia, and lethargy in adult horses. Although there are multiple reports of ECoV outbreaks, less is known about the clinical presentation of individual horses during a nonoutbreak situation. The purpose of this study was to describe the clinical presentation of horses diagnosed with ECoV infection that were not associated with an outbreak. Medical records of all horses admitted to Washington State University, Veterinary Teaching Hospital, during an 8-year period were reviewed (2010–2018). The five horses included in this study were older than 1 year of age, were diagnosed with colitis, tested positive for ECoV using real-time polymerase chain reaction, and were negative to other enteric pathogens. Interestingly, 4 of 5 horses had moderate to severe diarrhea, 3 had abnormal large colon ultrasonography, 2 had transient ventricular tachycardia and 2 had clinicopathologic evidence of liver dysfunction. ECoV should be included as a differential diagnosis for individual horses presenting with anorexia, fever, lethargy, and colitis. Early identification of ECoV cases is key to implement appropriate biosecurity measures to prevent the potential spread of this disease. © 2020 Elsevier Inc.",Anorexia; Colic; Diarrhea; Fever; Lethargy,agents used in inflammatory bowel disease; alkaline phosphatase; bile acid; biosponge; cotrimoxazole; ditrioctahedral smectite; flunixin meglumine; gamma glutamyltransferase; gastrogard; gentamicin; gluconate calcium; glucose; magnesium sulfate; metronidazole; omeprazole; penicillin G potassium; potassium chloride; sucralfate; triacylglycerol; unclassified drug; anorexia; Arabian horse; Article; clinical feature; colitis; Coronavirus infection; diarrhea; disease association; disease severity; echography; epidemic; equine coronavirus infection; fever; fluid therapy; gelding; heart ventricle tachycardia; hepatic lipidosis; hepatobiliary disease; horse breed; horse disease; human; lethargy; lipidosis; liver dysfunction; male; medical record review; megacolon; miniature horse; Quarter horse; real time polymerase chain reaction; retrospective study; teaching hospital; tennessee walking horse; university hospital; veterinary clinic; Washington,"Oue, Y., Morita, Y., Kondo, T., Nemoto, M., Epidemic of equine coronavirus at Obihiro Racecourse, Hokkaido, Japan in 2012 (2013) J Vet Med Sci, 75, pp. 1261-1265; Pusterla, N., Mapes, S., Wademan, C., White, A., Ball, R., Sapp, K., Emerging outbreaks associated with equine coronavirus in adult horses (2013) Vet Microbiol, 162, pp. 228-231; Pusterla, N., Vin, R., Leutenegger, C.M., Mittel, L.D., Divers, T.J., Enteric coronavirus infection in adult horses (2018) Vet J, 231, pp. 13-18; Berryhill, E.H., Magdesian, K.G., Aleman, M., Pusterla, N., Clinical presentation, diagnostic findings, and outcome of adult horses with equine coronavirus infection at a veterinary teaching hospital: 33 cases (2012-2018) (2019) Vet J, 248, pp. 95-100; Kooijman, L.J., James, K., Mapes, S.M., Theelen, M.J.P., Pusterla, N., Seroprevalence and risk factors for infection with equine coronavirus in healthy horses in the USA (2017) Vet J, 220, pp. 91-94; Manship, A.J., Blikslager, A.T., Elfenbein, J.R., Disease features of equine coronavirus and enteric salmonellosis are similar in horses (2019) J Vet Intern Med, 33, pp. 912-917; Pusterla, N., Vin, R., Leutenegger, C., Mittel, L.D., Divers, T.J., Equine coronavirus: an emerging enteric virus of adult horses (2016) Equine Vet Educ, 28, pp. 216-223; Bustin, S.A., Mueller, R., Real-time reverse transcription PCR (qRT-PCR) and its potential use in clinical diagnosis (2005) Clin Sci, 109, pp. 365-379; Nemoto, M., Oue, Y., Morita, Y., Kanno, T., Kinoshita, Y., Niwa, H., Experimental inoculation of equine coronavirus into Japanese draft horses (2014) Arch Virol, 159, pp. 3329-3334; Giannitti, F., Diab, S., Mete, A., Stanton, J.B., Fielding, L., Crossley, B., Necrotizing enteritis and Hyperammonemic encephalopathy associated with equine coronavirus infection in equids (2015) Vet Pathol, 52, pp. 1148-1156; Oue, Y., Ishihara, R., Edamatsu, H., Morita, Y., Yoshida, M., Yoshima, M., Isolation of an equine coronavirus from adult horses with pyrogenic and enteric disease and its antigenic and genomic characterization in comparison with the NC99 strain (2011) Vet Microbiol, 150, pp. 41-48; Miszczak, F., Tesson, V., Kin, N., Dina, J., Balasuriya, U.B.R., Pronost, S., First detection of equine coronavirus (ECoV) in Europe (2014) Vet Microbiol, 171, pp. 206-209; Fielding, C.L., Higgins, J.K., Higgins, J.C., McIntosh, S., Scott, E., Giannitti, F., Disease associated with equine coronavirus infection and high case Fatality rate (2015) J Vet Intern Med, 29, pp. 307-310; Sanz, M.G., Kwon, S., Pusterla, N., Gold, J.R., Bain, F., Evermann, J., Evaluation of equine coronavirus fecal shedding among hospitalized horses (2019) J Vet Intern Med, 33, pp. 918-922; Lohmann, K.L., Barton, M.H., Endotoxemia (2007) Equine infectious diseases, pp. 317-331. , D.C. Sellon M.T. Long Saunders Elsevier St. Louis; Reef, V.B., McGuirk, S.M., Diseases of the cardiovascular system (2009) Large animal internal medicine, pp. 453-489. , B. Smith 4th ed. Mosby Elsevier St. Louis, MO; Sellon, D., Long, M., Cardiovscular infenctions in Equine infectious diseases (2014), pp. 21-40. , 2nd ed. Mosby Elsevier St. Louis, MO; Schedlbauer, C., Blaue, D., Gericke, M., Blüher, M., Starzonek, J., Gittel, C., Brehm, W., Vervuert, I., Impact of body weight gain on hepatic metabolism and hepatic inflammatory cytokines in comparison of Shetland pony geldings and Warmblood horse geldings (2019) PeerJ, 7, p. e7069; Hesselkilde, E.Z., Almind, M.E., Petersen, J., Flethøj, M., Præstegaard, K.F., Buhl, R., Cardiac arrhythmias and electrolyte disturbances in colic horses (2014) Acta Vet Scand, 56, p. 58; Goodrich, E.L., Mittel, L.D., Glaser, A., Ness, S.L., Radcliffe, R.M., Divers, T.J., Novel findings from a beta coronavirus outbreak on an American Miniature Horse breeding farm in upstate New York (2020) Equine Vet Educ","Sanz, M.G.; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, P.O. Box 646610, United States; email: macarena@wsu.edu",,W.B. Saunders,7370806,,JEVSC,32172908,English,J. Equine Vet. Sci.,Article,Final,Open Access,Scopus,2-s2.0-85078214592,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Nishiura H., Linton N.M., Akhmetzhanov A.R.",7005501836;57214686285;18833652300;,Serial interval of novel coronavirus (COVID-19) infections,2020,International Journal of Infectious Diseases,93,,,284,286,,,10.1016/j.ijid.2020.02.060,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081989464&doi=10.1016%2fj.ijid.2020.02.060&partnerID=40&md5=99eae26c4cfc2b50c51561449f107456,"Graduate School of Medicine, Hokkaido University, Kia 15 Jo Nishi 7 Chome, Kitaku, Sapporo 060-8638, Japan; CREST, Japan Science and Technology Agency, Honcho 4-1-8, Kawaguchi, Saitama 332-0012, Japan","Nishiura, H., Graduate School of Medicine, Hokkaido University, Kia 15 Jo Nishi 7 Chome, Kitaku, Sapporo 060-8638, Japan, CREST, Japan Science and Technology Agency, Honcho 4-1-8, Kawaguchi, Saitama 332-0012, Japan; Linton, N.M., Graduate School of Medicine, Hokkaido University, Kia 15 Jo Nishi 7 Chome, Kitaku, Sapporo 060-8638, Japan; Akhmetzhanov, A.R., Graduate School of Medicine, Hokkaido University, Kia 15 Jo Nishi 7 Chome, Kitaku, Sapporo 060-8638, Japan","Objective: To estimate the serial interval of novel coronavirus (COVID-19) from information on 28 infector-infectee pairs. Methods: We collected dates of illness onset for primary cases (infectors) and secondary cases (infectees) from published research articles and case investigation reports. We subjectively ranked the credibility of the data and performed analyses on both the full dataset (n = 28) and a subset of pairs with highest certainty in reporting (n = 18). In addition, we adjust for right truncation of the data as the epidemic is still in its growth phase. Results: Accounting for right truncation and analyzing all pairs, we estimated the median serial interval at 4.0 days (95% credible interval [CrI]: 3.1, 4.9). Limiting our data to only the most certain pairs, the median serial interval was estimated at 4.6 days (95% CrI: 3.5, 5.9). Conclusions: The serial interval of COVID-19 is close to or shorter than its median incubation period. This suggests that a substantial proportion of secondary transmission may occur prior to illness onset. The COVID-19 serial interval is also shorter than the serial interval of severe acute respiratory syndrome (SARS), indicating that calculations made using the SARS serial interval may introduce bias. © 2020 The Author(s)",Coronavirus; Epidemiology; Generation time; Illness onset; Outbreak; Statistical model; Viruses,Article; clinical article; coronavirus disease 2019; Coronavirus infection; disease course; human; incubation time; serial interval; symptom; virus transmission,"Fine, P.E., The interval between successive cases of an infectious disease (2003) Am J Epidemiol, 158, pp. 1039-1047; Fraser, C., Riley, S., Anderson, R.M., Ferguson, N.M., Factors that make an infectious disease outbreak controllable (2004) Proc Natl Acad Sci U S A, 101 (16), pp. 6146-6151; Jung, S., Akhmetzhanov, A.R., Hayashi, K., Linton, N.M., Yang, Y., Yuan, B., Real-time estimation of the risk of death from novel coronavirus (COVID-19) infection: inference using exported cases (2020) J Clin Med, 9 (2); Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med, , in press; Linton, N.M., Kobayashi, T., Yang, Y., Hayashi, K., Andrei, A.R., Jung, S., Incubation period and other epidemiological characteristics of 2019 novel coronavirus infections with right truncation: a statistical analysis of publicly available case data (2020) J Clin Med, 9 (2); Lipsitch, M., Cohen, T., Cooper, B., Robins, J.M., Ma, S., James, L., Transmission dynamics and control of severe acute respiratory syndrome (2003) Science, 300 (5627), pp. 1966-1970; Nishiura, H., Kobayashi, T., Yang, Y., Hayashi, K., Miyama, T., Kinoshita, R., The rate of underascertainment of novel coronavirus (2019-nCoV) infection: estimation using Japanese passengers data on evacuation flights (2020) J Clin Med, 9 (2); Reich, N.G., Lessler, J., Cummings, D.A., Brookmeyer, R., Estimating incubation period distributions with coarse data (2009) Stat Med, 28, pp. 2769-2784; Rothe, C., Schunk, M., Sothmann, P., Bretzel, G., Froeschl, G., Wallrauch, C., Transmission of 2019-nCoV infection from an asymptomatic contact in Germany (2020) N Eng J Med, 382 (10), pp. 970-971; Stan Development Team, Stan Modeling Language Users Guide and Reference Manual (2014), http://mc-stan.org/manual.html","Nishiura, H.; Graduate School of Medicine, Hokkaido University, Kia 15 Jo Nishi 7 Chome, Japan; email: nishiurah@med.hokudai.ac.jp",,Elsevier B.V.,12019712,,IJIDF,32145466,English,Int. J. Infect. Dis.,Article,Final,Open Access,Scopus,2-s2.0-85081989464,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Albarello F., Pianura E., Di Stefano F., Cristofaro M., Petrone A., Marchioni L., Palazzolo C., Schininà V., Nicastri E., Petrosillo N., Campioni P., Eskild P., Zumla A., Ippolito G., Abbonizio M.A., Agrati C., Amadei G., Amendola A., Antonini M., Barbaro R., Bartolini B., Benigni M., Bevilacqua N., Bordi L., Bordoni V., Branca M., Capobianchi M.R., Caporale C., Caravella I., Carletti F., Castilletti C., Chiappini R., Ciaralli C., Colavita F., Corpolongo A., Curiale S., D'Abramo A., Dantimi C., Angelis A.D., Angelis G.D., Lorenzo R.D., Stefano F.D., Ferraro F., Fiorentini L., Frustaci A., Gallì P., Garotto G., Giancola M.L., Giansante F., Giombini E., Greci M.C., Lalle E., Lanini S., Lapa D., Lepore L., Lucia A., Lufrani F., Macchione M., Marani A., Mariano A., Marini M.C., Maritti M., Matusali G., Meschi S., Montaldo F.M.C., Murachelli S., Noto R., Pallini E., Passeri V., Pelliccioni F., Petrecchia A., Pisciotta M., Pittalis S., Proietti C., Puro V., Rinonapoli G., Rueca M., Sacchi A., Sanasi F., Santagata C., Scarcia S., Scognamiglio P., Scorzolini L., Stazi G., Vaia F., Vairo F., Valli M.B.",57189635032;55321199200;57202743791;36847741200;27968025900;6507508297;57215795104;6701418263;7004355827;57202570507;57215944460;57215596520;7006170723;57208096848;57215604755;6601911681;57215606108;7006014759;7004880592;57202519142;57215603873;57215596385;6602491600;8963521400;23092828600;57195512294;57202594512;57215600741;56916020000;57202569121;57211211954;57203677304;57215610892;57192341341;8718859500;57215610909;55485796200;6503850452;57194222435;57215596217;57215605905;57211156543;35104874600;57215601461;57215600287;57215604802;35740068000;6603873416;25623170700;35751386700;57215607921;23489455700;57202377000;35741093700;57194110887;57215599040;57215598985;57215606858;57215802006;57203678667;57215600597;6506129314;15136246400;14039539200;57215596426;55874276400;57215595334;57215599484;57215612101;57215601042;7801330979;57200810002;57209027344;57215604398;57211101049;57215611031;57195759326;23019544600;57215596859;37029779300;57215596669;6602227272;6507358073;57215610449;55359799800;36846052400;7102248255;,2019-novel Coronavirus severe adult respiratory distress syndrome in two cases in Italy: An uncommon radiological presentation,2020,International Journal of Infectious Diseases,93,,,192,197,,3,10.1016/j.ijid.2020.02.043,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081314502&doi=10.1016%2fj.ijid.2020.02.043&partnerID=40&md5=15ae51488524ecc3e33836a14c5d8488,"Lazzaro Spallanzani, National Institute for Infectious Diseases – IRCCS, Via Portuense, 292, Rome, cap 00148, Italy; Directorate General for Disease Surveillance and Control, Ministry of Health, Muscat, Oman; Institute for Clinical Medicine, Faculty of Health Science, University of Aarhus, Denmark; ESCMID Emerging Infections Task Force, Basel, Switzerland; Department of Infection, Division of Infection and Immunity, University College London, and NIHR Biomedical Research Centre, University College London Hospitals NHS Foundation Trust, London, United Kingdom","Albarello, F., Lazzaro Spallanzani, National Institute for Infectious Diseases – IRCCS, Via Portuense, 292, Rome, cap 00148, Italy, ; Pianura, E., Lazzaro Spallanzani, National Institute for Infectious Diseases – IRCCS, Via Portuense, 292, Rome, cap 00148, Italy, ; Di Stefano, F., Lazzaro Spallanzani, National Institute for Infectious Diseases – IRCCS, Via Portuense, 292, Rome, cap 00148, Italy; Cristofaro, M., Lazzaro Spallanzani, National Institute for Infectious Diseases – IRCCS, Via Portuense, 292, Rome, cap 00148, Italy, ; Petrone, A., Lazzaro Spallanzani, National Institute for Infectious Diseases – IRCCS, Via Portuense, 292, Rome, cap 00148, Italy, ; Marchioni, L., Lazzaro Spallanzani, National Institute for Infectious Diseases – IRCCS, Via Portuense, 292, Rome, cap 00148, Italy, ; Palazzolo, C., Lazzaro Spallanzani, National Institute for Infectious Diseases – IRCCS, Via Portuense, 292, Rome, cap 00148, Italy, ; Schininà, V., Lazzaro Spallanzani, National Institute for Infectious Diseases – IRCCS, Via Portuense, 292, Rome, cap 00148, Italy, ; Nicastri, E., Lazzaro Spallanzani, National Institute for Infectious Diseases – IRCCS, Via Portuense, 292, Rome, cap 00148, Italy, ; Petrosillo, N., Lazzaro Spallanzani, National Institute for Infectious Diseases – IRCCS, Via Portuense, 292, Rome, cap 00148, Italy, ; Campioni, P., Lazzaro Spallanzani, National Institute for Infectious Diseases – IRCCS, Via Portuense, 292, Rome, cap 00148, Italy, ; Eskild, P., Directorate General for Disease Surveillance and Control, Ministry of Health, Muscat, Oman, Institute for Clinical Medicine, Faculty of Health Science, University of Aarhus, Denmark, ESCMID Emerging Infections Task Force, Basel, Switzerland; Zumla, A., Department of Infection, Division of Infection and Immunity, University College London, and NIHR Biomedical Research Centre, University College London Hospitals NHS Foundation Trust, London, United Kingdom; Ippolito, G., Lazzaro Spallanzani, National Institute for Infectious Diseases – IRCCS, Via Portuense, 292, Rome, cap 00148, Italy, ; Abbonizio, M.A.; Agrati, C.; Amadei, G.; Amendola, A.; Antonini, M.; Barbaro, R.; Bartolini, B.; Benigni, M.; Bevilacqua, N.; Bordi, L.; Bordoni, V.; Branca, M.; Capobianchi, M.R.; Caporale, C.; Caravella, I.; Carletti, F.; Castilletti, C.; Chiappini, R.; Ciaralli, C.; Colavita, F.; Corpolongo, A.; Curiale, S.; D'Abramo, A.; Dantimi, C.; Angelis, A.D.; Angelis, G.D.; Lorenzo, R.D.; Stefano, F.D.; Ferraro, F.; Fiorentini, L.; Frustaci, A.; Gallì, P.; Garotto, G.; Giancola, M.L.; Giansante, F.; Giombini, E.; Greci, M.C.; Lalle, E.; Lanini, S.; Lapa, D.; Lepore, L.; Lucia, A.; Lufrani, F.; Macchione, M.; Marani, A.; Mariano, A.; Marini, M.C.; Maritti, M.; Matusali, G.; Meschi, S.; Montaldo, F.M.C.; Murachelli, S.; Noto, R.; Pallini, E.; Passeri, V.; Pelliccioni, F.; Petrecchia, A.; Pisciotta, M.; Pittalis, S.; Proietti, C.; Puro, V.; Rinonapoli, G.; Rueca, M.; Sacchi, A.; Sanasi, F.; Santagata, C.; Scarcia, S.; Scognamiglio, P.; Scorzolini, L.; Stazi, G.; Vaia, F.; Vairo, F.; Valli, M.B.","Introduction: Several recent case reports have described common early chest imaging findings of lung pathology caused by 2019 novel Coronavirus (SARS-COV2) which appear to be similar to those seen previously in SARS-CoV and MERS-CoV infected patients. Objective: We present some remarkable imaging findings of the first two patients identified in Italy with COVID-19 infection travelling from Wuhan, China. The follow-up with chest X-Rays and CT scans was also included, showing a progressive adult respiratory distress syndrome (ARDS). Results: Moderate to severe progression of the lung infiltrates, with increasing percentage of high-density infiltrates sustained by a bilateral and multi-segmental extension of lung opacities, were seen. During the follow-up, apart from pleural effusions, a tubular and enlarged appearance of pulmonary vessels with a sudden caliber reduction was seen, mainly found in the dichotomic tracts, where the center of a new insurgent pulmonary lesion was seen. It could be an early alert radiological sign to predict initial lung deterioration. Another uncommon element was the presence of mediastinal lymphadenopathy with short-axis oval nodes. Conclusions: Although only two patients have been studied, these findings are consistent with the radiological pattern described in literature. Finally, the pulmonary vessels enlargement in areas where new lung infiltrates develop in the follow-up CT scan, could describe an early predictor radiological sign of lung impairment. © 2020 The Authors",COVID-19; Crazy-paving; CT-scan; Enlarged pulmonary vessels; Ground glass opacities; SARS-COV2,2019 novel coronavirus; adult respiratory distress syndrome; aged; Article; artificial ventilation; case report; China; clinical article; computer assisted tomography; cone beam computed tomography; Coronavirinae; Coronavirus infection; female; follow up; human; human tissue; intensive care unit; Italy; laboratory test; lung blood vessel; lung infiltrate; lung lesion; male; mediastinum lymphadenopathy; multidetector computed tomography; pericardial effusion; pleura effusion; real time reverse transcription polymerase chain reaction; spiral computer assisted tomography; thorax radiography,"Chan, J.F., Yuan, S., Kok, K.H., To, K.K., Chu, H., Yang, J., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet; Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet; Chung, M., Bernheim, A., Mei, X., Zhang, N., Huang, M., Zeng, X., CT imaging features of 2019 novel coronavirus (SARS-COV2) (2020) Radiology; Corman, V.M., Landt, O., Kaiser, M., Molenkamp, R., Meijer, A., Chu, D.K., Detection of 2019 novel coronavirus (SARS-COV2) by real-time RT-PCR (2020) Euro Surveill, 25 (3); Das, K.M., Lee, E.Y., Al Jawder, S.E., Enani, M.A., Singh, R., Skakni, L., Acute middle east respiratory syndrome coronavirus: temporal lung changes observed on the chest radiographs of 55 patients (2015) AJR Am J Roentgenol, 205 (3), pp. W267-74; Das, K.M., Lee, E.Y., Enani, M.A., AlJawder, S.E., Singh, R., Bashir, S., CT correlation with outcomes in 15 patients with acute Middle East respiratory syndrome coronavirus (2015) AJR Am J Roentgenol, 204 (4), pp. 736-742; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet; Kanne, J.P., Chest CT findings in 2019 novel coronavirus (SARS-COV2) infections from Wuhan, China: key points for the radiologist (2020) Radiology; Koo, H.J., Lim, S., Choe, J., Choi, S.H., Sung, H., Do, K.H., Radiographic and CT features of viral pneumonia (2018) Radiographics, 38 (3), pp. 719-739; Lei, J., Li, J., Li, X., Qi, X., CT Imaging of the 2019 Novel Coronavirus (SARS-COV2) Pneumonia (2020) Radiology; Liu, P., Tan, X.Z., 2019 Novel coronavirus (SARS-COV2) pneumonia (2020) Radiology; Nestor, L., Müller, G.C.O., Khong, P.L., Zhou, L.J., Tsang, K.W.T., Nicolaou, S., High-resolution CT findings of severe acute respiratory syndrome at presentation and after admission (2004) Am J Roentgenol, 182 (1), pp. 39-44; Nicolaou, S., Al-Nakshabandi, N.A., Muller, N.L., SARS: imaging of severe acute respiratory syndrome (2003) AJR Am J Roentgenol, 180 (5), pp. 1247-1249; Ooi, G.C., Khong, P.L., Müller, N.L., Yiu, W.C., Zhou, L.J., Ho, J.C.M., Severe acute respiratory syndrome: temporal lung changes at thin-section CT in 30 Patients (2004) Radiology, 230 (3), pp. 836-844; Organization WH, Novel Coronavirus(SARS-COV2) Situation Report – 19 2020 (2020), https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200208-sitrep-19-ncov.pdf?sfvrsn=6e091ce6_2, [Available from]:; Organization WH, Laboratory testing for 2019 novel coronavirus (SARS-COV2) in suspected human cases. Interim guidance (2020); Organization WH, World experts and funders set priorities for COVID-19 research (2020), https://www.who.int/news-room/detail/12-02-2020-world-experts-and-funders-set-priorities-for-covid-19-research, [Available from]:; Pan, Y., Guan, H., Imaging changes in patients with SARS-COV2 (2020) Eur Radiol; Song, F., Shi, N., Shan, F., Zhang, Z., Shen, J., Lu, H., Emerging coronavirus SARS-COV2 pneumonia (2020) Radiology; Wang, C., Horby, P.W., Hayden, F.G., Gao, G.F., A novel coronavirus outbreak of global health concern (2020) Lancet; Wenhui Li, M.J.M., Vasilieva, N., Sui, J., Wong, S.K., Berne, M.A., Somasundaran, M., Thomas C Greenough, Hyeryun Choe, Michael Farzan. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus (2003) Nature, 426 (6965), pp. 450-454","Schininà, V.Via Portuense, 292, cap 00148, Italy; email: vincenzo.schinina@inmi.it",,Elsevier B.V.,12019712,,IJIDF,32112966,English,Int. J. Infect. Dis.,Article,Final,Open Access,Scopus,2-s2.0-85081314502,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Farooq H.Z., Davies E., Ahmad S., Machin N., Hesketh L., Guiver M., Turner A.J.",57215580429;57191983790;57215588473;55880543100;6603739900;7005174149;57202568187;,Middle East respiratory syndrome coronavirus (MERS-CoV) — Surveillance and testing in North England from 2012 to 2019,2020,International Journal of Infectious Diseases,93,,,237,244,,,10.1016/j.ijid.2020.01.043,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081228203&doi=10.1016%2fj.ijid.2020.01.043&partnerID=40&md5=cf0d8b0c4da97885bd6b16978d319735,"Department of Virology, Manchester University NHS Foundation Trust, Manchester, United Kingdom; Department of Infectious Diseases and Tropical Medicine, North Manchester General Hospital, Manchester, United Kingdom; Public Health Laboratory Manchester, Manchester, United Kingdom; University of Manchester, Manchester, United Kingdom","Farooq, H.Z., Department of Virology, Manchester University NHS Foundation Trust, Manchester, United Kingdom, Department of Infectious Diseases and Tropical Medicine, North Manchester General Hospital, Manchester, United Kingdom, Public Health Laboratory Manchester, Manchester, United Kingdom; Davies, E., Department of Virology, Manchester University NHS Foundation Trust, Manchester, United Kingdom, Public Health Laboratory Manchester, Manchester, United Kingdom; Ahmad, S., Department of Virology, Manchester University NHS Foundation Trust, Manchester, United Kingdom, Department of Infectious Diseases and Tropical Medicine, North Manchester General Hospital, Manchester, United Kingdom, Public Health Laboratory Manchester, Manchester, United Kingdom; Machin, N., Department of Virology, Manchester University NHS Foundation Trust, Manchester, United Kingdom, Public Health Laboratory Manchester, Manchester, United Kingdom, University of Manchester, Manchester, United Kingdom; Hesketh, L., Department of Virology, Manchester University NHS Foundation Trust, Manchester, United Kingdom, Public Health Laboratory Manchester, Manchester, United Kingdom, University of Manchester, Manchester, United Kingdom; Guiver, M., Department of Virology, Manchester University NHS Foundation Trust, Manchester, United Kingdom, Public Health Laboratory Manchester, Manchester, United Kingdom, University of Manchester, Manchester, United Kingdom; Turner, A.J., Department of Virology, Manchester University NHS Foundation Trust, Manchester, United Kingdom, Public Health Laboratory Manchester, Manchester, United Kingdom, University of Manchester, Manchester, United Kingdom","Background: Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in Saudi Arabia in 2012 and caused an epidemic in the Middle East. Public Health England (PHE) Manchester is one of the two PHE centres in the UK that perform testing for MERS-CoV. The results of the PHE Manchester MERS surveillance from 2012 to 2019 are presented in this report. Methods: Retrospective data were collected for returning travellers from the Middle East fitting the PHE MERS case definition. Respiratory samples were tested for respiratory viruses and MERS-CoV using an in-house RT-PCR assay. Results: Four hundred and twenty-six (426) samples from 264 patients were tested for MERS Co-V and respiratory viruses. No MERS-CoV infections were identified by PCR. Fifty-six percent of samples were PCR positive for viral or bacterial pathogen with Influenza A as the predominant virus (44%). Sixty-two percent of all patients had a pathogen identified with the highest positivity from sputum samples. Patients with multiple samples demonstrated a 100% diagnostic yield. Conclusions: Although no cases of MERS were identified, the majority of patients had Influenza infection for which oseltamivir treatment was indicated and isolation warranted. Sputum samples were the most useful in diagnosing respiratory viruses with a 100% diagnostic yield from patients with multiple samples. © 2020 The Authors",EID; Emerging infectious disease; HCID; High consequence infectious disease; MERS; MERS-CoV; Middle East respiratory syndrome coronavirus; Public health epidemiological surveillance,aged; Article; Caucasian; controlled study; diagnostic value; disease surveillance; female; health care personnel; human; influenza A; major clinical study; male; methicillin susceptible Staphylococcus aureus infection; Middle East respiratory syndrome; Middle East respiratory syndrome coronavirus; real time polymerase chain reaction; respiratory tract infection; retrospective study; travel; very elderly,"Annan, A., Owusu, M., Marfo, K.S., Larbi, R., Sarpong, F.N., Adu-Sarkodie, Y., High prevalence of common respiratory viruses and no evidence of Middle East respiratory syndrome coronavirus in Hajj pilgrims returning to Ghana, 2013 (2015) Trop Med Int Health, 20 (6), pp. 807-812; Arabi, Y.M., Arifi, A.A., Balkhy, H.H., Najm, H., Aldawood, A.S., Ghabashi, A., Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection (2014) Ann Intern Med, 160 (6), pp. 389-397; Assiri, A., Al-Rabeeah, A.A., Alhakeem, R.F., Memish, Z.A., Zumla, A., Drosten, C., Respiratory tract samples, viral load, and genome fraction yield in patients with Middle East respiratory syndrome (2014) J Infect Dis, 210 (10), pp. 1590-1594; Atabani, S.F., Wilson, S., Overton-Lewis, C., Workman, J., Kidd, I.M., Petersen, E., Active screening and surveillance in the United Kingdom for Middle East respiratory syndrome coronavirus in returning travellers and pilgrims from the Middle East: a prospective descriptive study for the period 2013–2015 (2016) Int J Infect Dis, 47, pp. 10-14; Benkouiten, S., Charrel, R., Belhouchat, K., Drali, T., Nougairede, A., Salez, N., Respiratory viruses and bacteria among pilgrims during the 2013 Hajj (2014) Emerg Infect Dis, 20 (11), pp. 1821-1827; Bermingham, A., Chand, M.A., Brown, C.S., Aarons, E., Tong, C., Langrish, C., Severe respiratory illness caused by a novel coronavirus, in a patient transferred to the United Kingdom from the Middle East, September 2012 (2012) Eurosurveillance, 17 (40), p. 20290; Diagnostics, A., RealStar® MERS-CoV RT-PCR Kits CE (2019), https://www.altona-diagnostics.com/en/products/reagents-140/reagents/realstar-real-time-pcr-reagents/realstar-mers-cov-rt-pcr-kit-ce.html, Available from:; Falsey, A.R., Formica, M.A., Walsh, E.E., Yield of sputum for viral detection by reverse transcriptase PCR in adults hospitalized with respiratory illness (2012) J Clin Microbiol, 50 (1), pp. 21-24; Hijawi, B., Abdallat, M., Sayaydeh, A., Alqasrawi, S., Haddadin, A., Novel coronavirus infections in Jordan: epidemiological findings from a retrospective investigation (2013) East Mediterr Health J, 19 Suppl 1, pp. S12-8; Manchester City Council M, Ethnic group by broad age and sex 2011 (2011), https://secure.manchester.gov.uk/downloads/download/4220/public_intelligence_population_publications, Available from:; http://www.manchester.gov.uk/download/downloads/id/16474/a17_2011_ethnic_groups_by_broad_age_and_sex.pdf; Moon, S.-Y., Son, J.S., Infectivity of an asymptomatic patient with Middle East respiratory syndrome coronavirus infection (2017) Clin Infect Dis, 64 (10), pp. 1457-1458; Office for National Statistics O, Population estimates for UK, England and Wales, Scotland and Northern Ireland (2019), https://www.ons.gov.uk/peoplepopulationandcommunity/populationandmigration/populationestimates/datasets/populationestimatesforukenglandandwalesscotlandandnorthernireland, Available from:; Park, H.Y., Lee, E.J., Ryu, Y.W., Kim, Y., Kim, H., Lee, H., Epidemiological investigation of MERS-CoV spread in a single hospital in South Korea, May to June 2015* (2015) Eurosurveillance, 20 (25), p. 21169; (PHE) PHE, Investigation and public health management of possible cases of Middle East respiratory syndrome coronavirus (MERS-CoV) (v31 – August 2018) (2018) Public Health England (PHE), 1, pp. 1-2; (PHE) PHE, MERS-CoV case in England - PHE press release (2018), p. 1. , PHE Published 23 August 2018 - Last updated 4 October 2018; PHE, MERS-CoV case in England — PHE press release [press release] (2018), PHE Online: PHE2018; Public Health England P, Interim guidance: handling and processing of specimens associated with Middle East respiratory syndrome coronavirus (MERS-CoV) in clinical diagnostic laboratories (2016), https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/517215/InterimguidancehandlingprocessingspecimensMERSCoVinclinicaldiagnosticlabs.pdf, Available from:; Refaey, S., Amin, M.M., Roguski, K., Azziz-Baumgartner, E., Uyeki, T.M., Labib, M., Cross-sectional survey and surveillance for influenza viruses and MERS-CoV among Egyptian pilgrims returning from Hajj during 2012-2015 (2017) Influenza Other Respir Viruses, 11 (1), pp. 57-60; Review, W.P., Manchester population. (2018-11-21) (2018), Retrieved 25 February 2019; Sing, A., Trebesius, K., Roggenkamp, A., Rüssmann, H., Tybus, K., Pfaff, F., Evaluation of diagnostic value and epidemiological implications of PCR for Pneumocystis carinii in different immunosuppressed and immunocompetent patient groups (2000) J Clin Microbiol, 38 (4), pp. 1461-1467; The Health Protection Agency UK Novel Coronavirus Investigation team C, Evidence of person-to-person transmission within a family cluster of novel coronavirus infections, United Kingdom, February 2013 (2013) Eurosurveillance, 18 (11), p. 20427; UK Civil Aviation Authority C, CAA airport data 2016-2017 (2017), Available from:; WHO, WHO MERS-CoV global summary and assessment of risk, November 2019 (WHO/MERS/RA/November 2019) (2019), Geneva, Switzerland November WHO; World Health Organization W, Middle East respiratory syndrome coronavirus (MERS-CoV) Factsheet (2019), https://www.who.int/emergencies/mers-cov/en, [Available from: /. Accessed 18 December 2019]; Zaki, A.M., van Boheemen, S., Bestebroer, T.M., Osterhaus, A.D.M.E., Fouchier, R.A.M., Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia (2012) N Engl J Med, 367 (19), pp. 1814-1820; Zumla, A., Dar, O., Kock, R., Muturi, M., Ntoumi, F., Kaleebu, P., Taking forward a ‘One Health’ approach for turning the tide against the Middle East respiratory syndrome coronavirus and other zoonotic pathogens with epidemic potential (2016) Int J Infect Dis, 47, pp. 5-9","Farooq, H.Z.; Department of Virology, Manchester Royal Infirmary, Manchester University NHS Foundation Trust, Oxford Road, United Kingdom; email: H.farooq@nhs.net",,Elsevier B.V.,12019712,,IJIDF,32004690,English,Int. J. Infect. Dis.,Article,Final,Open Access,Scopus,2-s2.0-85081228203,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Robson B.,7004890572;,"Computers and viral diseases. Preliminary bioinformatics studies on the design of a synthetic vaccine and a preventative peptidomimetic antagonist against the SARS-CoV-2 (2019-nCoV, COVID-19) coronavirus",2020,Computers in Biology and Medicine,119,,103670,,,,,10.1016/j.compbiomed.2020.103670,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080113143&doi=10.1016%2fj.compbiomed.2020.103670&partnerID=40&md5=20591589e42188a314929e38a2d3e90d,"Ingine Inc., Cleveland, OH, United States; The Dirac FoundationOxfordshire, United Kingdom","Robson, B., Ingine Inc., Cleveland, OH, United States, The Dirac FoundationOxfordshire, United Kingdom","This paper concerns study of the genome of the Wuhan Seafood Market isolate believed to represent the causative agent of the disease COVID-19. This is to find a short section or sections of viral protein sequence suitable for preliminary design proposal for a peptide synthetic vaccine and a peptidomimetic therapeutic, and to explore some design possibilities. The project was originally directed towards a use case for the Q-UEL language and its implementation in a knowledge management and automated inference system for medicine called the BioIngine, but focus here remains mostly on the virus itself. However, using Q-UEL systems to access relevant and emerging literature, and to interact with standard publically available bioinformatics tools on the Internet, did help quickly identify sequences of amino acids that are well conserved across many coronaviruses including 2019-nCoV. KRSFIEDLLFNKV was found to be particularly well conserved in this study and corresponds to the region around one of the known cleavage sites of the SARS virus that are believed to be required for virus activation for cell entry. This sequence motif and surrounding variations formed the basis for proposing a specific synthetic vaccine epitope and peptidomimetic agent. The work can, nonetheless, be described in traditional bioinformatics terms, and readily reproduced by others, albeit with the caveat that new data and research into 2019-nCoV is emerging and evolving at an explosive pace. Preliminary studies using molecular modeling and docking, and in that context the potential value of certain known herbal extracts, are also described. © 2020 Elsevier Ltd",2019-nCoV coronavirus; Automatic browser; Bioinformatics; Peptidomimetic; Q-UEL language; Retroinverso; Synthetic vaccine; Wuhan seafood market coronavirus,Bioinformatics; Commerce; Knowledge management; Plant extracts; Vaccines; Automatic browser; Coronaviruses; Peptidomimetics; Q-UEL language; Retroinverso; Synthetic vaccines; Diseases,"Masters, P.S., The molecular biology of coronaviruses (2006) Adv. Virus Res., 66, pp. 193-292; Robson, B., Preliminary Bioinformatics Studies on the Design of Synthetic Vaccines and Preventative Peptidomimetic Antagonists against the Wuhan Seafood Market Coronavirus. Possible Importance of the KRSFIEDLLFNKV Motif, Circulated and Published on ResearchGate (2010); Wu, F., Zhao, S., Yu, B., Chen, Y.-M., Wang, W., Hu, Y., Song, Z.-G., Zhang, Y.-Z., A Novel Coronavirus Associated with a Respiratory Disease in Wuhan of Hubei Province, China, Wuhan Seafood Market Pneumonia Virus Isolate Wuhan-Hu-1, Complete Genome (2019), https://www.ncbi.nlm.nih.gov/nuccore/MN908947, GenBank submission MN908947.3 (Accessed 26 January 2020); Li, F., Structure, function, and evolution of coronavirus spike proteins (2016) Annu. Rev. Virol., 3 (1), pp. 237-261; Kam, Y.W., Okumura, Y., Kido, H., Ng, L.F.P., Bruzzone, R., Altmeyer, R., Cleavage of the SARS coronavirus spike glycoprotein by airway proteases enhances virus entry into human bronchial epithelial cells in vitro published (2009) PloS One, , November 17 (Accessed 26 January 2020); Belouzard, S., Chu, V.C., Whittaker, G.R., Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites, Proc. Natl. Acad. Sci., 106(14, 5871-5876; (last accessed 1/26/2020); Gui, M., Song, W., Zhou, H., Xu, J., Chen, S., Xiang, Y., Wang, X., Entity 1 containing Chain A, B, C SARS-CoV spike glycoprotein (2017) Cell Res., 27, pp. 119-129; Liu, I.J., Tsai, W.T., Hsieh, L.E., Chueh, L.L., Peptides corresponding to the predicted heptad repeat 2 domain of the feline coronavirus spike protein are potent inhibitors of viral infection (2013) PloS One, 8 (12); Forni, D., Filippi, G., Cagliani, R., De Gioia, L., Pozzoli, U., Al-Daghri, N., Clerici, M., Sironi, M., The heptad repeat region is a major selection target in MERS-CoV and related coronaviruses (2015) Sci. Rep., 5, p. 4480; Berend, J.B., Rossen, J.W.A., Bartelink, W., Zuurveen, C., de Hann, A.M., Duquerroy, Boucher, C.A.B., Rottier, P.J., Coronavirus escape from heptad repeat 2 (HR2)-Derived peptide entry inhibition as a result of mutations in the HR1 domain of the spike fusion protein (2008) J. Virol., pp. 2580-2585. , March; Robson, B., Garnier, J., Introduction to Proteins and Protein Engineering (1998), second ed. Elsevier Press; Sachdeva, S., Peptides as ‘drugs’: the journey so far (2017) Int. J. Pept. Res. Therapeut., 23, p. 49. , (2017); Li, W., Joshi, M.D., Singhania, S., Rasey, K.H., Murthy, A.K., Peptide vaccine: progress and challenges (2014) Vaccines (Basel), 2 (3), pp. 515-536; Robson, B., Fishleigh, R.V., Morrison, C.A., Prediction of HIV vaccine (1987) Nature, 4 (325), p. 395; Fishleigh, R.V., Robson, B., (1990), Synthetic Peptides Related to HIV-Env Proteins, patent Patent: EP00371046A1; Fishleigh, R.V., Robson, B., Aston, R., Synthetic Polypeptides Derived from the HIV Envelope Glycoprotein.Patent: EU0636145 (1995); Fishleigh, R.V., Robson, B., (1995), Fragments of Prion Proteins, patent EP00636145A1,; Fishleigh, R.V., Robson, B., Mee, P., (1998), Fragments of Prion Proteins patent US05773572; Citywire https://citywire.co.uk/new-model-adviser/news/protherics-mad-cow-test-goes-international/a220861, (Accessed 28 January 2020); Robson, B., From Zika to Flu and Back Again (2016), https://www.researchgate.net/publication/296667599_From_Zika_to_Flu_and_Back_Again_CAVIRC_Caribbean_Anti-Virus_Informatics_Research_Center, CAVIRC (Report of the Caribbean Anti-Virus Informatics Research Center); Robson, B., Computer aided peptide and protein engineering (1986) Applied Biotechnology, Proceedings of Biotech 86' Europe, Held in London, 1, pp. B9-B14; Robson, B., Ward, D.J., Marsden, A., The EPSITRON concept of peptide and protein engineering. Applications of computer-aided molecular design (1986) Chem. Des. Autom. News, 1 (7), pp. 9-11; Robson, B., Platt, E., Marsden, A., Millard, P., An expert system for protein engineering. Its application in the study of chloramphenicol acetyltransferase and avian pancreatic polypeptide (1987) J. Mol. Graph., 5, pp. 8-17. , (1987); Fishleigh, R.V., Robson, B., Garnier, J., Finn, P.W., Studies on rationales for an expert system approach to the analysis of protein sequence data - preliminary analysis of the human epidermal growth factor receptor (1987) FEBS Lett., 2 (4), pp. 219-225; Garnier, J., Gibrat, J.F., Levin, J., Robson, B., Modélisation des polypeptides: application aux oligopeptides vaccinants” INRA/EUC Rapport FRT - 85 T 0606 (1988); Ball, J., Fishleigh, R.V., Greaney, P.J., Marsden, A., Platt, E., Pool, L.J., Robson, B., A polymorphic programming environment for the chemical pharmaceutical and biotechnology industries (1990) Chemical Information Systems - beyond the Structure Diagrams, pp. 107-123. , D. Bawden E.M. Mitchell Ellis Horwood Press; Robson, B., Platt, E., Li, J., Computer aided design of biomolecules: the big hammer approach (1992) Theoretical Biochemistry and Molecular Biophysics 2 Proteins, pp. 207-222. , David L. Beveridge Richard Lavery Adenine Press; Robson, B., Caruso, T., Balis, U.G.J., Suggestions for a web based universal exchange and inference language for medicine (2013) Comput. Biol. Med., 43 (12), pp. 2297-2310. , 1; Robson, B., Boray, S., Implementation of a web based universal exchange and inference language for medicine. Sparse data, probabilities and inference in data mining of clinical data repositories (2015) Comput. Biol. Med., 66, pp. 82-102; Robson, B., Boray, S., Interesting things for computer systems to do: keeping and data mining millions of patient records, guiding patients and physicians, and passing medical licensing exams (2015) Bioinformatics and Biomedicine (BIBM), Proceedings 2015 IEEE International Conference, pp. 1397-1404. , IEEE; Robson, B., Boray, S., Data-mining to build a knowledge representation store for clinical decision support. Studies on curation and validation based on machine performance in multiple choice medical licensing examinations (2016) Comput. Biol. Med., 73, pp. 71-93; Robson, B., Boray, S., Studies of the role of a smart web for precision medicine supported by biobanking, personalized medicine (2016) FTG, 13 (4); Robson, B., Studies in using a universal exchange and inference language for evidence based medicine. Semi-automated learning and reasoning for PICO methodology, systematic review, and environmental epidemiology (2016) Comput. Biol. Med., 79, pp. 299-323; Robson, B., Boray, S., Studies in the extensively automatic construction of large odds-based inference networks from structured data. Examples from medical, bioinformatics, and health insurance claims data (2018) Comput. Biol. Med., 95, pp. 147-166; Robson, B., Boray, S., (2019), Studies in the use of data mining, prediction algorithms, and a universal exchange and inference language in the analysis of socioeconomic health data”, Comput. Biol. Med., Sep;112 doi: 10.1016/j.compbiomed.2019.103369. [Epub ahead of print]; Robson, B., Extension of the Quantum Universal Exchange Language to precision medicine and drug lead discovery. Preliminary example studies using the mitochondrial genome (2020) Comput. Biol. Med., 117; The biology Workbench http://workbench.sdsc.edu/, (Accessed 28 January 2020); National center for biotechnology information, national institutes of health, BLASTP SUITE https://blast.ncbi.nlm.nih.gov/Blast.cgi, (Accessed 28 January 2020); Garnier, J., Robson, B., The GOR method for predicting secondary structure in proteins (1989) Prediction of Protein Structure and the Principles of Protein Conformation, pp. 417-465. , G.D. Fasman Plenum Publishing Corp; Rhone-alpes Institute of biology and protein chemistry https://npsa-prabi.ibcp.fr/cgi-bin/npsa_automat.pl?page=/NPSA/npsa_gor4.html, GOR IV (Accessed 28 January 2020); De Lima, D.P., Synthesis of angiotensin-converting enzyme (ACE) inhibitors: an important class of antihypertensive drugs (1999) Quim. Nova, 22 (3); Robson, B., Beyond proteins (1999) Trends Biotechnol., 17 (8), pp. 311-315. , B. Robson, ""Doppelganger Proteins as Drug Leads"", B. Robson (1996), Nature Biotechnology, 14, 892-893 (1966); Figliozzi, G.M., Siani, M.A., Canne, L.E., Robson, B., Simon, R.J., Chemical synthesis and activity of D, superoxide dismutase (1996) Protein Sci., 5, p. 72. , 15; Robson, B., Pseudoproteins: Non-protein Protein-like Machines, the Sixth Foresight Conference on Molecular Nanotechnology (1998), https://foresight.org/Conferences/MNT6/Abstracts/Robson/index.html, (Accessed 7 September 2019); Rai, J., Peptide and protein mimetics by retro and retroinverso analogs (2019) Chem. Biol. Drug Des., 93 (5), pp. 724-736; Hagler, A.T., Osguthorpe, D.J., Robson, B., Monte Carlo simulation of water behaviour around the dipeptide N-acetylalanyl-N'methylamide (1980) Science, 208, pp. 599-601; Robson, B., Some views of solvation effects in the light of a Monte Carlo simulation (1982) The Biophysics of Water, pp. 66-67. , F. Franks F.S. Mathias John Wiley & Sons Ltd; Robson, B., Dettinger, R., Peters, A., Boyer, S.K.P., Drug discovery using very large numbers of patents: general strategy with extensive use of match and edit operations (2011) J. Comput. Aided Mol. Des., 25 (5), p. 427; Soria-Guerr, R.E., Nieto-Gomez, R., Govea-Alonso, B.O., Rosales-Mendoza, S., An overview of bioinformatics tools for epitope prediction: implications on vaccine development (2015) J. Biomed. Inf., 53, pp. 405-414; Kao, D.J., Hodges, R.S., Advantages of a synthetic peptide immunogen over a protein immunogen in the development of an anti-pilus vaccine for Pseudomonas aeruginosa (2009) Chem. Biol. Drug Des., 74, pp. 33-42; Palatnik-de-Sousa1, C.B., Soares, I.D.S., Rosa, D.S., (2018) Front. Immunol., , (2018); Van Regenmortel, M.H.V., Synthetic peptide vaccines and the search for neutralization B cell epitopes (2009) Open Vaccine J., 2, pp. 33-44; Wan, Y., Shang, J., Graham, R., Baric, R.S., Li, F., An analysis based on decade-long structural studies of SARS 3, JVI Accepted Manuscript Posted Online 29 January 2020 (2020) J. Virol.; Katz, B.A., Luong, C., Ho, J.D., Somoza, J.R., Gjerstad, E., Tang, J., Williams, S.R., McGrath, M.E., Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA) (2004) J. Mol. Biol., 344 (2), pp. 527-547. , 19; Lennart, M.R., Reinke, M., Spiegel, M., Plegge, T., Hartleib, A., Nehlmeier, I., Gierer, S., Pöhlmann1, S., Different residues in the SARS-CoV spike protein determine cleavage and activation by the host cell protease TMPRSS2 (2017) PloS One, 12 (6); Barr'e, O., Dufour, A., Eckhard, U., Kappelhoff, R., Béliveau, F., Leduc, R., Overall, C.M., Cleavage specificity analysis of six type II transmembrane serine proteases (TTSPs) using PICS with proteome-derived peptide libraries (2014) PloS One, 9 (9). , (2014); Ho, T.Y., Wu, S.L., Chen, J.C., Hsiang, C.Y., Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction (2007) Antivir. Res., 74 (2), pp. 92-101; Schwarz, S., Wang, K., Yu, W., Sun, B., Schwarz, Emodin inhibits current through SARS-associated coronavirus 3a protein (2011) Antivir. Res., 90 (1), pp. 64-69; Adedeji, A.O., Severson, W., Jonsson, C., Singh, K., Weiss, S.R., Sarafian, S.G., Novel inhibitors of severe acute respiratory syndrome coronavirus entry that act by three distinct mechanisms (2013) J. Virol., 87 (14), pp. 8017-8028; Feng, Y., Huang, S.-L., Dou, W., Zhang, S., Chen, J.-H., Shen, Y., Shen, J.-H., Leng, Y., Emodin, a natural product, selectively inhibits 11β-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice (2010) Br. J. Pharmacol., 161 (1), pp. 113-126; Westphal, U., Hydrophobicity and hydrophilicity of steroid binding sites (1986) Steroid-Protein Interactions II. Monographs on Endocrinology, 27. , Springer; Robson, B., Curioni, A., Mordasini, T., Studies in the assessment of folding quality for protein modeling and structure prediction (2002) J. Proteome Res. (Am. Chem. Soc.), 1 (2), pp. 115-133. , (2002); Robson, B., Vaithilingham, A., “Protein folding revisited” pp 161-202 in progress in molecular biology and translational science (2008) Molecular Biology of Protein Folding, 84. , Elsevier Press/Academic Press (2008); Li, J., Robson, B., Bioinformatics and Computational Chemistry in Molecular Design. Recent Advances and Their Application, Pp 285-307 in Peptide and Protein Drug Analysis (2000), p. 200. , Marcel Dekker NY; Robson, B., McBurney, R., The role of information, bioinformatics and genomics (2012) Drug Discovery and Development: Technology in Transition, pp. 77-94. , R.G. Hill P. Rang second ed. Elsevier Press; Smith, D., Robson, High Throughput Insight: Web-Based Collections of Bioinformatics Tools Catalyzes Scientific Inquiry into Subtle Aspects of Gene Structure and Function (1998), IBC Library Series; Ali, A., Khan, A., Kaushik, A.C., Immunoinformatic and systems biology approaches to predict and validate peptide vaccines against Epstein–Barr virus (EBV) (2019) Sci. Rep., 9, p. 720; Kaliamurthi, S., Selvaraj, G., Chinnasamy, S., Wang, Q., Nangraj, A.S., Cho, W.C., Gu, K., Wei, D.-Q., Exploring the papillomaviral proteome to identify potential candidates for a chimeric vaccine against cervix papilloma using immunomics and computational structural vaccinology (2019) Viruses, 11, p. 63; Mehmood, A., Aman, C.K., Wei, D.-Q., Prediction and validation of potent peptides against herpes simplex virus type 1 via immunoinformatic and systems biology approach (2019) Chem. Biol. Drug Des., 94 (5), pp. 1868-1883; Chu, Kaushik, A. C Wang, X., Wang, W., Zhang, Y., Shan, X Russell, D., Salahub, Xiong, Y., Wei, D-Q, DTI-CDF: Acascade deep forest model towards the prediction of drug-target interactions based on hybrid features, Briefings Bioinf., bbz152,; Kaushik, A.C., Mehmood, A., Upadhyay, A.K., Shalinee, P., Srivastava, S., Prayuv, M., Xiong, Y., Sahi, S., CytoMegaloVirus infection database: a public omics database for systematic and comparable information of CMV (2019) Interdiscipl. Sci. Comput. Life Sci., , [Epub ahead of print]; Kaushik, A.C., Mehmood, A., Peng, S., Zhang, Y.J., Dai, X., Wei, D.-Q., A-CaMP: a tool for anti-cancer and antimicrobial peptide generation (2020) J. Biomol. Struct. Dyn., , published online, 6 Jan; Wikipedia, contagion (film) https://en.wikipedia.org/wiki/Contagion, (2011_film, last access (2/1/202)); Khan, M.Y., Kumar, V., Mechanism & inhibition kinetics of bioassay-guided fractions of Indian medicinal plants and foods as ACE inhibitors (2019) J. Tradit. Complementary Med., 9 (1), pp. 73-78; Robson, B., Quantum universal exchange language and hyperbolic Dirac nets for precision medicine and drug design. Proposals with examples from mitochondrial studies (2016) Comput. Biol. Med., 117; Robson, B., Boray, S., Studies in the use of data mining, prediction algorithms, and a universal exchange and inference language in the analysis of socioeconomic health data (2019) Comput. Biol. Med., , Sep;112 in press [Epub ahead of print]; Robson, B., Bidirectional General Graphs for inference. Principles and implications for medicine (2019) Comput. Biol. Med., 10, pp. 382-399. , (2019); Robson, B., Boray, S., Studies in the extensively automatic construction of large odds-based inference networks from structured data. Examples from medical, bioinformatics, and health insurance claims data (2018) Comput. Biol. Med., 95, pp. 147-166; Robson, B., Studies in using a universal exchange and inference language for evidence based medicine. Semi-automated learning and reasoning for PICO methodology, systematic review, and environmental epidemiology (2016) Comput. Biol. Med., 79, pp. 299-323; Robson, B., Boray, S., Studies of the role of a smart web for precision medicine supported by biobanking (2016) Pers. Med., 13, p. 4. , Published Online:5 Jul 2016; Robson, B., Boray, S., Data-mining to build a knowledge representation store for clinical decision support. Studies on curation and validation based on machine performance in multiple choice medical licensing examinations (2016) Comput. Biol. Med., 73, pp. 71-93; Robson, B., Boray, S., Interesting things for computer systems to do: keeping and data mining millions of patient records, guiding patients and physicians, and passing medical licensing exams (2015) Bioinformatics and Biomedicine (BIBM), Proceedings 2015 IEEE International Conference, pp. 1397-1404. , IEEE; Robson, B., Boray, S., Implementation of a web based universal exchange and inference language for medicine. Sparse data, probabilities and inference in data mining of clinical data repositories (2015) Comput. Biol. Med., 66, pp. 82-102; Deckelman, S., Robson, B., Split-complex numbers and Dirac bra-kets (2015) Commun. Inf. Syst., 14 (3), pp. 135-149; Robson, B., Caruso, T., Balis, U.G.J., Suggestions for a web based universal exchange and inference language for medicine. Continuity of patient care with PCAST disaggregation (2014) Comput. Biol. Med., 56, pp. 51-66; Robson, B., POPPER, a simple programming language for probabilistic semantic inference in medicine (2014) Comput. Biol. Med., 56, pp. 107-123; Robson, B., hyperbolic Dirac nets for medical decision support. Theory, methods, and comparison with bayes nets (2014) Comput. Biol. Med., 51, pp. 183-197; Robson, B., Caruso, T., Balis, U.G.J., Suggestions for a web based universal exchange and inference language for medicine (2013) Comput. Biol. Med., 43 (12), pp. 2297-2310. , http://wiki.siframework.org/file/view/UELRobson102corrections.pdf/451304614/UELRobson102corrections.pdf, 1 Epub 2013 Sep 20.Also found in preliminary form, with permission of the Editor-in-Chief, at the US Government S&I website:-; Robson, B., The concept of novel compositions of matter. A theoretical analysis (2013) Intellect. Property Rights, 1, p. 108; Robson, B., Towards new tools for pharmacoepidemiology (2013) Adv. Pharmacoepidemiol. Drug Saf., 1, p. 6; Robson, B., McBurney, R., The Role of Information, Bioinformatics and Genomics” in Drug Discovery & Development. Technology in Transition (2013), pp. 77-94. , second ed. Churchill Livingstone (Elsevier; Robson, B., Towards automated reasoning for drug discovery and pharmaceutical business intelligence (2012) Pharmaceut. Technol. Drug Res., 1 (3). , 2012 ( 27 March 2012) Robson, B., Li, J., Dettinger, R., Peters, A., and Boyer, S.K. (2011), Drug discovery using very large numbers of patents. General strategy with extensive use of match and edit operations. Journal of Computer-Aided Molecular Design 25(5): 427-441 (2011); Robson, B., Balis, U.G.J., Caruso, T.P., Considerations, for a universal exchange language for healthcare (2011) In Proceedings of 2011 IEEE 13th International Conference on E-Health Networking, Applications and Services (Healthcom 2011), pp. 173-176. , IEEE Columbus, MO 2011","Robson, B.; Ingine Inc.United States; email: barryrobson@ingine.com",,Elsevier Ltd,104825,,CBMDA,32209231,English,Comput. Biol. Med.,Article,Final,Open Access,Scopus,2-s2.0-85080113143,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Yoon S.H., Lee K.H., Kim J.Y., Lee Y.K., Ko H., Kim K.H., Park C.M., Kim Y.-H.",57213117888;57201824662;57211142178;57216096410;57215856674;57212056779;57215387097;35313444300;,Chest radiographic and ct findings of the 2019 novel coronavirus disease (Covid-19): Analysis of nine patients treated in korea,2020,Korean Journal of Radiology,21,4,,498,504,,,10.3348/kjr.2020.0132,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082108980&doi=10.3348%2fkjr.2020.0132&partnerID=40&md5=abe689c51f19985927da5ad7c87902ab,"Department of Radiology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, South Korea; Department of Radiology, Seoul National University Bundang Hospital, Seongnam, South Korea; Department of Internal Medicine, Incheon Medical Center, Incheon, South Korea; Department of Radiology, Seoul Medical Center, Seoul, South Korea; Department of Radiology, National Medical Center, Seoul, South Korea; Department of Radiology, Myongji Hospital, Goyang, South Korea; Department of Radiology, Chonnam National University Hospital, Gwangju, South Korea","Yoon, S.H., Department of Radiology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, South Korea; Lee, K.H., Department of Radiology, Seoul National University Bundang Hospital, Seongnam, South Korea; Kim, J.Y., Department of Internal Medicine, Incheon Medical Center, Incheon, South Korea; Lee, Y.K., Department of Radiology, Seoul Medical Center, Seoul, South Korea; Ko, H., Department of Radiology, National Medical Center, Seoul, South Korea; Kim, K.H., Department of Radiology, Myongji Hospital, Goyang, South Korea; Park, C.M., Department of Radiology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, South Korea; Kim, Y.-H., Department of Radiology, Chonnam National University Hospital, Gwangju, South Korea","Objective: This study presents a preliminary report on the chest radiographic and computed tomography (CT) findings of the 2019 novel coronavirus disease (COVID-19) pneumonia in Korea. Materials and Methods: As part of a multi-institutional collaboration coordinated by the Korean Society of Thoracic Radiology, we collected nine patients with COVID-19 infections who had undergone chest radiography and CT scans. We analyzed the radiographic and CT findings of COVID-19 pneumonia at baseline. Fisher’s exact test was used to compare CT findings depending on the shape of pulmonary lesions. Results: Three of the nine patients (33.3%) had parenchymal abnormalities detected by chest radiography, and most of the abnormalities were peripheral consolidations. Chest CT images showed bilateral involvement in eight of the nine patients, and a unilobar reversed halo sign in the other patient. In total, 77 pulmonary lesions were found, including patchy lesions (39%), large confluent lesions (13%), and small nodular lesions (48%). The peripheral and posterior lung fields were involved in 78% and 67% of the lesions, respectively. The lesions were typically ill-defined and were composed of mixed ground-glass opacities and consolidation or pure ground-glass opacities. Patchy to confluent lesions were primarily distributed in the lower lobes (p = 0.040) and along the pleura (p < 0.001), whereas nodular lesions were primarily distributed along the bronchovascular bundles (p = 0.006). Conclusion: COVID-19 pneumonia in Korea primarily manifested as pure to mixed ground-glass opacities with a patchy to confluent or nodular shape in the bilateral peripheral posterior lungs. A considerable proportion of patients with COVID-19 pneumonia had normal chest radiographs. © 2020 The Korean Society of Radiology.",Chest X-ray; Computed tomography; Coronavirus; COVID-19; Pneumonia,"adult; Article; atelectasis; clinical article; computer assisted tomography; coronavirus disease 2019; disease severity; female; follow up; ground glass opacity; human; image analysis; Korea; lung examination; lung lesion; male; middle aged; parenchymal abnormality; pneumonia; polymerase chain reaction; radiological parameters; retrospective study; thorax radiography; Coronavirus infection; diagnostic imaging; lung; South Korea; thorax; thorax radiography; virus pneumonia; x-ray computed tomography; COVID-19; Coronavirus Infections; Female; Humans; Lung; Male; Middle Aged; Pneumonia, Viral; Radiography, Thoracic; Republic of Korea; Thorax; Tomography, X-Ray Computed","Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., China Novel Coronavirus Investigating and Research Team. A novel Coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382, pp. 727-733; Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Early transmission dynamics in Wuhan, China, of novel Coronavirus-infected pneumonia (2020) N Engl J Med, , https://doi.org/10.1056/NEJMoa2001316; Coronavirus disease 2019 (COVID-19) situation report–27 (2020) World Health Organization, , https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200216-sitrep-27-covid-19.pdf?sfvrsn=78c0eb78_2; Chung, M., Bernheim, A., Mei, X., Zhang, N., Huang, M., Zeng, X., CT imaging features of 2019 novel Coronavirus (2019-nCoV) (2020) Radiology, , https://doi.org/10.1148/radiol.2020200230; Song, F., Shi, N., Shan, F., Zhang, Z., Shen, J., Lu, H., Emerging coronavirus 2019-nCoV pneumonia (2020) Radiology, , https://doi.org/10.1148/radiol.2020200274; Pan, F., Ye, T., Sun, P., Gui, S., Liang, B., Li, L., Time course of lung changes on chest CT during recovery from 2019 novel Coronavirus (COVID-19) pneumonia (2020) Radiology, , https://doi.org/10.1148/radiol.2020200370; Kim, J.Y., Choe, P.G., Oh, Y., Oh, K.J., Kim, J., Park, S.J., The first case of 2019 novel Coronavirus pneumonia imported into Korea from Wuhan, China: Implication for infection prevention and control measures (2020) J Korean Med Sci, 35, p. e61; Taylor, E., Haven, K., Reed, P., Bissielo, A., Harvey, D., McArthur, C., SHIVERS Investigation Team. A chest radiograph scoring system in patients with severe acute respiratory infection: A validation study (2015) BMC Med Imaging, 15, p. 61; Hansell, D.M., Bankier, A.A., Macmahon, H., McLoud, T.C., Müller, N.L., Remy, J., Fleischner Society: Glossary of terms for thoracic imaging (2008) Radiology, 246, pp. 697-722; Ajlan, A.M., Ahyad, R.A., Jamjoom, L.G., Alharthy, A., Madani, T.A., Middle East respiratory syndrome Coronavirus (MERS-CoV) infection: Chest CT findings (2014) AJR am J Roentgenol, 203, pp. 782-787; Das, K.M., Lee, E.Y., Enani, M.A., Aljawder, S.E., Singh, R., Bashir, S., CT correlation with outcomes in 15 patients with acute Middle East respiratory syndrome coronavirus (2015) AJR am J Roentgenol, 204, pp. 736-742; Wong, K.T., Antonio, G.E., Hui, D.S., Lee, N., Yuen, E.H., Wu, A., Thin-section CT of severe acute respiratory syndrome: Evaluation of 73 patients exposed to or with the disease (2003) Radiology, 228, pp. 395-400; Choi, W.J., Lee, K.N., Kang, E.J., Lee, H., Middle East respiratory syndrome-Coronavirus infection: A case report of serial computed tomographic findings in a young male patient (2016) Korean J Radiol, 17, pp. 166-170; Wan, Y.L., Tsay, P.K., Cheung, Y.C., Chiang, P.C., Wang, C.H., Tsai, Y.H., A correlation between the severity of lung lesions on radiographs and clinical findings in patients with severe acute respiratory syndrome (2007) Korean J Radiol, 8, pp. 466-474; Antonio, G.E., Ooi, C.G., Wong, K.T., Tsui, E.L., Wong, J.S., Sy, A.N., Radiographic-clinical correlation in severe acute respiratory syndrome: Study of 1373 patients in Hong Kong (2005) Radiology, 237, pp. 1081-1090; Wong, K.T., Antonio, G.E., Hui, D.S., Lee, N., Yuen, E.H., Wu, A., Severe acute respiratory syndrome: Radiographic appearances and pattern of progression in 138 patients (2003) Radiology, 228, pp. 401-406; Das, K.M., Lee, E.Y., Al Jawder, S.E., Enani, M.A., Singh, R., Skakni, L., Acute Middle East respiratory syndrome Coronavirus: Temporal lung changes observed on the chest radiographs of 55 patients (2015) AJR am J Roentgenol, 205, pp. W267-W274; Lin, X., Gong, Z., Xiao, Z., Xiong, J., Fan, B., Liu, J., Novel Coronavirus pneumonia outbreak in 2019: Computed tomographic findings in two cases (2020) Korean J Radiol, , https://doi.org/10.3348/kjr.2020.0078; Ng, M.Y., Lee, E.Y.P., Yang, J., Yang, F., Li, X., Wang, H., Imaging profile of the COVID-19 infection: Radiologic findings and literature review (2020) Radiology: Cardiothoracic Imaging, 2; Fang, Y., Zhang, H., Xu, Y., Xie, J., Pang, P., Ji, W., CT manifestations of two cases of 2019 novel Coronavirus (2019-nCoV) pneumonia (2020) Radiology, , https://doi.org/10.1148/radiol.2020200280; Kong, W., Agarwal, P.P., Chest imaging appearance of COVID-19 infection (2020) Radiology: Cardiothoracic Imaging, 2; Godoy, M.C., Viswanathan, C., Marchiori, E., Truong, M.T., Benveniste, M.F., Rossi, S., The reversed halo sign: Update and differential diagnosis (2012) Br J Radiol, 85, pp. 1226-1235","Yoon, S.H.; Department of Radiology, Seoul National University College of Medicine, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, South Korea; email: yshoka@gmail.com",,Korean Radiological Society,12296929,,,32100485,English,Korean J. Radiol.,Article,Final,,Scopus,2-s2.0-85082108980,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wang W., Tang J., Wei F.",57214886882;57196949618;57190227227;,"Updated understanding of the outbreak of 2019 novel coronavirus (2019-nCoV) in Wuhan, China",2020,Journal of Medical Virology,92,4,,441,447,,19,10.1002/jmv.25689,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078823813&doi=10.1002%2fjmv.25689&partnerID=40&md5=eec4aa0df9d8e5453c5b7de1d2d296c4,"Department of Hepatobiliary and Pancreatic Surgery, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China; Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China; Department of Radiation Oncology, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China","Wang, W., Department of Hepatobiliary and Pancreatic Surgery, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China, Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China; Tang, J., Department of Radiation Oncology, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China; Wei, F., Department of Hepatobiliary and Pancreatic Surgery, Zhejiang Provincial People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China","To help health workers and the public recognize and deal with the 2019 novel coronavirus (2019-nCoV) quickly, effectively, and calmly with an updated understanding. A comprehensive search from Chinese and worldwide official websites and announcements was performed between 1 December 2019 and 9:30 am 26 January 2020 (Beijing time). A latest summary of 2019-nCoV and the current outbreak was drawn. Up to 24 pm, 25 January 2020, a total of 1975 cases of 2019-nCoV infection were confirmed in mainland China with a total of 56 deaths having occurred. The latest mortality was approximately 2.84% with a total of 2684 cases still suspected. The China National Health Commission reported the details of the first 17 deaths up to 24 pm, 22 January 2020. The deaths included 13 males and 4 females. The median age of the people who died was 75 (range 48-89) years. Fever (64.7%) and cough (52.9%) were the most common first symptoms among those who died. The median number of days from the occurence of the first symptom to death was 14.0 (range 6-41) days, and it tended to be shorter among people aged 70 years or more (11.5 [range 6-19] days) than those aged less than 70 years (20 [range 10-41] days; P =.033). The 2019-nCoV infection is spreading and its incidence is increasing nationwide. The first deaths occurred mostly in elderly people, among whom the disease might progress faster. The public should still be cautious in dealing with the virus and pay more attention to protecting the elderly people from the virus. © 2020 Wiley Periodicals, Inc.",coronavirus; epidemiology; infection,"2019 novel coronavirus; adult; aged; Article; cause of death; China; Chinese; comorbidity; controlled study; Coronavirinae; Coronavirus infection; coronavirus infection 2019; coughing; disease course; female; fever; human; incidence; major clinical study; male; mortality; nonhuman; Coronavirus infection; epidemic; Hong Kong; Macao; middle aged; Taiwan; very elderly; virus pneumonia; COVID-19; Aged; Aged, 80 and over; China; Coronavirus Infections; Disease Outbreaks; Hong Kong; Humans; Macau; Middle Aged; Pneumonia, Viral; Taiwan","Wuhan Municipal Health Commission's briefing on the pneumonia epidemic situation, , http://wjw.wuhan.gov.cn/front/web/showDetail/2019123108989, Released on 31 December 2019 (in Chinese); (2020) New-type coronavirus causes pneumonia in Wuhan: expert, , http://www.xinhuanet.com/english/2020-01/09/c_138690570.htm, Released on 9 January; (2020) Coronavirus, , https://www.who.int/health-topics/coronavirus, Accessed 20 January; Luo, G.G., Gao, S.J., Global health concern stirred by emerging viral infections (2020) J Med Virol, , https://doi.org/10.1002/jmv.25683, (Epub ahead of print, 22 January 2020); National Health Commission's briefing on the pneumonia epidemic situation. Released on 26 January 2020 (in Chinese), , http://www.nhc.gov.cn/yjb/s7860/202001/9614b05a8cac4ffabac10c4502fe517c.shtml; Stop the Wuhan virus (2020) Nature, 577 (7791), p. 450; Chen, Y., Liu, Q., Guo, D., Coronaviruses: genome structure, replication, and pathogenesis (2020) J Med Virol, , https://doi.org/10.1002/jmv.25681, (Epub ahead of print, 22 January 2020); Kan, B., Wang, M., Jing, H., Molecular evolution analysis and geographic investigation of severe acute respiratory syndrome coronavirus-like virus in palm civets at an animal market and on farms (2005) J Virol, 79 (18), pp. 11892-11900; Li, W., Shi, Z., Yu, M., Bats are natural reservoirs of SARS-like coronaviruses (2005) Science, 310 (5748), pp. 676-679; Xu, X.T., Chen, P., Wang, J.F., Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission (2020) Science China Life Sci, , https://doi.org/10.1007/s11427-020-1637-5, (Epub ahead of print, 21 January 2020); Ji, W., Wang, W., Zhao, X., Zai, J., Li, X., Homologous recombination within the spike glycoprotein of the newly identified coronavirus may boost cross-species transmission from snake to human (2020) J Med Virol, , https://doi.org/10.1002/jmv.25682, (Epub ahead of print, 22 January 2020); (2020) Statement on the meeting of the International Health Regulations (2005) Emergency Committee regarding the outbreak of novel coronavirus (2019-nCoV), , https://www.who.int/news-room/detail/23-01-2020-statement-on-the-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-outbreak-of-novel-coronavirus-(2019-ncov, Released on 23 January; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, , https://doi.org/10.1016/S0140-6736(20)30183-5A, (Epub ahead of print, 24 January 2020); Chan, J.F.-W., Yuan, S., Kok, K.-H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, , https://doi.org/10.1016/S0140-6736(20)30154-9, (Epub ahead of print, 24 January 2020); (2020) Wuhan Municipal Health Commission's briefing on the pneumonia epidemic situation, , http://wjw.wuhan.gov.cn/front/web/showDetail/2020011109035, Released on 11 January, (in Chinese); (2020) National Health Commission's briefing on the pneumonia epidemic situation, , http://www.nhc.gov.cn/wjw/xwdt/202001/6be45fe493804bb6b96a3ed6c92ddb0f.shtml, Released on 20 January, (in Chinese); (2020) National Health Commission's briefing on the pneumonia epidemic situation, , http://www.nhc.gov.cn/yjb/s3578/202001/a3c8b5144067417889d8760254b1a7ca.shtml, Released on 22 January, (in Chinese); (2020) National Health Commission's briefing on the pneumonia epidemic situation, , http://www.nhc.gov.cn/yjb/s3578/202001/5d19a4f6d3154b9fae328918ed2e3c8a.shtml, Released on 23 January, (in Chinese); (2020) CCTV News’ briefing on the pneumonia epidemic situation, , https://m.weibo.cn/status/4463810716443567?, Released on 23 January, (in Chinese); (2020) National Health Commission's briefing on the pneumonia epidemic situation, , http://www.nhc.gov.cn/yjb/s3578/202001/c5da49c4c5bf4bcfb320ec2036480627.shtml, Released on 24 January, (in Chinese); (2020) CCTV News’ briefing on the pneumonia epidemic situation, , https://weibo.com/2656274875/IqVnfb1Hm?from=page_1002062656274875_profile&wvr=6&mod=weibotime&type=comment#_rnd1579829037898, Released on 24 January, (in Chinese); (2020) National Health Commission's briefing on the pneumonia epidemic situation, , http://www.nhc.gov.cn/yjb/s7860/202001/a7cf0437d1324aed9cc1b890b8ee29e6.shtml, Released on 25 January, (in Chinese); (2020) China Youth Daily's briefing on the pneumonia epidemic situation, , https://www.weibo.com/1726918143/Ir5mwyjCa?from=page_1002061726918143_profile&wvr=6&mod=weibotime&type=comment#_rnd1580006559334, 25 January, (in Chinese); (2020) China Youth Daily's briefing on the pneumonia epidemic situation, , https://weibo.com/1726918143/IrexYtgQf?from=page_1002061726918143_profile&wvr=6&mod=weibotime&type=comment#_rnd1580006246121, Released on 26 January, (in Chinese); (2003) Summary of probable SARS cases with onset of illness from 1 November 2002 to 31 July 2003, , https://www.who.int/csr/sars/country/table2003_09_23/en/, Released on 26 September; (2020) Middle East Respiratory Syndrome Coronavirus (MERS-CoV), , http://www.who.int/emergencies/mers-cov/en/, Accessed 25 January; (2003) Acute respiratory syndrome in China-Update 3, , https://www.who.int/csr/don/2003_2_20/en/, Released on 20 February; Oh, M., Park, W.B., Park, S.W., Middle East respiratory syndrome: what we learned from the 2015 outbreak in the Republic of Korea (2018) Korean J Intern Med, 33 (2), pp. 233-246; Feng, D., Jia, N., Fang, L.Q., Duration of symptom onset to hospital admission and admission to discharge or death in SARS in mainland China: a descriptive study (2009) Trop Med Int Health, 14, pp. 28-35; (2020) Update and Interim Guidance on Outbreak of 2019 Novel Coronavirus (2019-nCoV) in Wuhan, China, , https://emergency.cdc.gov/han/han00426.asp, Released on 17 January; (2020) Interim 2019 novel coronavirus (2019-nCoV) patient under investigation (PUI) form, , https://www.cdc.gov/coronavirus/2019-ncov/downloads/pui-form.pdf, Released on 17 January; (2020) Infection prevention and control during health care when novel coronavirus (nCoV) infection is suspected, , https://www.who.int/publications-detail/infection-prevention-and-control-during-health-care-when-novel-coronavirus-(ncov)-infection-is-suspected, Interim guidance. Released on 13 January; (2020) Home care for patients with suspected novel coronavirus (nCoV) infection presenting with mild symptoms and management of contacts, , https://www.who.int/internal-publications-detail/home-care-for-patients-with-suspected-novel-coronavirus-(nCoV)-infection-presenting-with-mild-symptoms-and-management-of-contacts, Interim guidance. Released on 20 January; Prevention and control of pneumonia from novel coronavirus infection (2nd ed.), , http://www.nhc.gov.cn/jkj/s3577/202001/c67cfe29ecf1470e8c7fc47d3b751e88.shtml, Released on 22 January 2020 (in Chinese)","Tang, J.; Department of Radiation Oncology, Zhejiang Provincial People's Hospital, Hangzhou Medical CollegeChina; email: 15900792812@163.com",,John Wiley and Sons Inc.,1466615,,JMVID,31994742,English,J. Med. Virol.,Article,Final,Open Access,Scopus,2-s2.0-85078823813,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Ivanov D.,56350235000;,Predicting the impacts of epidemic outbreaks on global supply chains: A simulation-based analysis on the coronavirus outbreak (COVID-19/SARS-CoV-2) case,2020,Transportation Research Part E: Logistics and Transportation Review,136,,101922,,,,,10.1016/j.tre.2020.101922,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081998325&doi=10.1016%2fj.tre.2020.101922&partnerID=40&md5=8498f3b8ae38cfec272338bdd6e7ff89,"Berlin School of Economics and Law, Department of Business Administration, Professor for Supply Chain and Operations Management, Berlin, 10825, Germany","Ivanov, D., Berlin School of Economics and Law, Department of Business Administration, Professor for Supply Chain and Operations Management, Berlin, 10825, Germany","Epidemic outbreaks are a special case of supply chain (SC) risks which is distinctively characterized by a long-term disruption existence, disruption propagations (i.e., the ripple effect), and high uncertainty. We present the results of a simulation study that opens some new research tensions on the impact of COVID-19 (SARS-CoV-2) on the global SCs. First, we articulate the specific features that frame epidemic outbreaks as a unique type of SC disruption risks. Second, we demonstrate how simulation-based methodology can be used to examine and predict the impacts of epidemic outbreaks on the SC performance using the example of coronavirus COVID-19 and anyLogistix simulation and optimization software. We offer an analysis for observing and predicting both short-term and long-term impacts of epidemic outbreaks on the SCs along with managerial insights. A set of sensitivity experiments for different scenarios allows illustrating the model's behavior and its value for decision-makers. The major observation from the simulation experiments is that the timing of the closing and opening of the facilities at different echelons might become a major factor that determines the epidemic outbreak impact on the SC performance rather than an upstream disruption duration or the speed of epidemic propagation. Other important factors are lead-time, speed of epidemic propagation, and the upstream and downstream disruption durations in the SC. The outcomes of this research can be used by decision-makers to predict the operative and long-term impacts of epidemic outbreaks on the SCs and develop pandemic SC plans. Our approach can also help to identify the successful and wrong elements of risk mitigation/preparedness and recovery policies in case of epidemic outbreaks. The paper is concluded by summarizing the most important insights and outlining future research agenda. © 2020 Elsevier Ltd",Coronavirus; COVID-19; Digital twin; Epidemic outbreak; Pandemic plan; Resilience; Risk management; SARS-CoV-2; Simulation; Supply chain,computer simulation; decision making; disease spread; economic impact; epidemic; future prospect; prediction; risk assessment; severe acute respiratory syndrome; supply chain management; Coronavirus; SARS coronavirus,"Aboah, J., Wilson, M.M.J., Bicknell, K., Rich, K.M., Identifying the precursors of vulnerability in agricultural value chains: A system dynamics approach (2019) Int. J. Prod. Res.; Aldrighetti, R., Zennaro, I., Finco, S., Battini, D., Healthcare supply chain simulation with disruption considerations: a case study from northern Italy (2019) Global J. Flexible Syst. Manage., 20, pp. 81-102; Altay, N., Pal, R., Information diffusion among agents: implications for humanitarian operations (2014) Prod. Oper. 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Manage., 28 (2), pp. 441-456",,,Elsevier Ltd,13665545,,,,English,Transp. Res. Part E Logist. Transp. Rev.,Article,Final,Open Access,Scopus,2-s2.0-85081998325,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Addie D., Houe L., Maitland K., Passantino G., Decaro N.",7003910352;57209209539;7004593107;56711401600;6701636107;,Effect of cat litters on feline coronavirus infection of cell culture and cats,2020,Journal of Feline Medicine and Surgery,22,4,,350,357,,3,10.1177/1098612X19848167,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85066844800&doi=10.1177%2f1098612X19848167&partnerID=40&md5=b2457b4bfee0ba383079295e93b10951,"Institute of Comparative Medicine, University of Glasgow, Glasgow, United Kingdom; Reg Acc, Felismir Katteklinik, Hvalso, Denmark; Department of Veterinary Medicine, University of Bari, Bari, Italy","Addie, D., Institute of Comparative Medicine, University of Glasgow, Glasgow, United Kingdom; Houe, L., Reg Acc, Felismir Katteklinik, Hvalso, Denmark; Maitland, K., Institute of Comparative Medicine, University of Glasgow, Glasgow, United Kingdom; Passantino, G., Department of Veterinary Medicine, University of Bari, Bari, Italy; Decaro, N., Department of Veterinary Medicine, University of Bari, Bari, Italy","Objectives: Feline infectious peritonitis (FIP) is caused by infection with feline coronavirus (FCoV). FCoV is incredibly contagious and transmission is via the faecal–oral route. FCoV infection, and therefore FIP, is most common in breeder and rescue catteries, where many cats are kept indoors, using litter trays. Whether it is possible to break the cycle of FCoV infection and reinfection using cat litters has never been investigated. The aim of the study was to examine the effect of cat litters on FCoV infectivity and virus load in multi-cat households, and transmission frequency. Methods: Fifteen cat litters were mixed and incubated with FCoV, centrifuged and the supernatants tested in vitro for the ability to prevent virus infection of cell culture. To test applicability of in vitro results to real life, virus load was measured in two households in a double crossover study of four Fuller’s earth-based cat litters by testing rectal swabs using FCoV reverse transcriptase quantitative PCR. Results: Four litters abrogated FCoV infection of cell culture, nine reduced it to a greater or lesser extent and two had no effect. One brand had different virus inhibitory properties depending on where it was manufactured. Fuller’s earth-based litters performed best, presumably by adsorbing virus. In the field study, there appeared to be less virus shedding on one Fuller’s earth-based cat litter. Conclusions and relevance: The in vitro study successfully identified cat litters that inactivate FCoV; such litters exist so do not need to be developed. Fuller’s earth-based litters best prevented infection of cell culture, but did not completely abrogate FCoV transmission in two multi-cat households. A dust-free clumping Fuller’s earth litter appeared to fare best, but virus shedding also varied on the control litters, complicating interpretation. Sawdust-based cat litters are not useful in FCoV-endemic households because they track badly and have a poor effect on virus infection. © The Author(s) 2019.",Bentonite; cat litter; Dr Elsey; FCoV infection; Feline coronavirus; feline infectious peritonitis; FIP; Fuller’s earth; reducing virus load; virus inhibition,3' untranslated region; animal cell; animal experiment; Article; cat; cat litter; cell culture; controlled study; Coronavirus infection; crossover procedure; embryo cell; feces; Feline coronavirus; feline infectious peritonitis; female; household; nonhuman; priority journal; prospective study; real time reverse transcription polymerase chain reaction; reinfection; solid waste; virus inhibition; virus load; virus shedding; virus transmission,"De Groot, R.J., Baker, S.C., Baric, R., Family Coronaviridae (2012) Ninth report international committee on taxonomy of viruses, pp. 806-828. , King A.M.Q., Adams M.J., Carstens E.B., (eds), Elsevier, Amsterdam, In; Herrewegh, A.A.P.M., Smeenk, I., Horzinek, M.C., Feline coronavirus type II strains 79–1683 and 79–1146 originate from a double recombination between feline coronavirus type I and canine coronavirus (1998) J Virol, 72, pp. 4508-4514; 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Scott, F.W., Update on FIP (1988) Proc Kal Kan Symp, 12, pp. 43-47; Hickman, M.A., Morris, J.G., Rogers, Q.R., Elimination of feline coronavirus infection from a large experimental specific pathogen-free cat breeding colony by serologic testing and isolation (1995) Feline Pract, 23, pp. 96-102; Gut, M., Leutenegger, C.M., Huder, J.B., One-tube fluorogenic reverse transcription-polymerase chain reaction for the quantitation of feline coronaviruses (1999) J Virol Methods, 77, pp. 37-46; O’Reilly, K.J., Fishman, B., Hitchcock, L.M., Feline infectious peritonitis: isolation of a coronavirus (1979) Vet Rec, 104, p. 348; Jarrett, O., Laird, H.M., Hay, D., Determinants of the host range of feline leukaemia virus (1973) J Gen Virol, 20, pp. 169-175; Ramakrishnan, M.A., Determination of 50% endpoint titer using a simple formula (2016) World J Virol, 5, pp. 85-86; Lorusso, E., Mari, V., Losurdo, M., Discrepancies between feline coronavirus antibody and nucleic acid detection in effusions of cats with suspected feline infectious peritonitis (2019) Res Vet Sci, 125, pp. 421-424; Vennema, H., Poland, A., Foley, J., Feline infectious peritonitis viruses arise by mutation from endemic feline enteric coronaviruses (1998) Virology, 243, pp. 150-157; Gerber, J.D., Ingersoll, J.D., Gast, A.M., Protection against feline infectious peritonitis by intranasal inoculation of a temperature-sensitive FIPV vaccine (1990) Vaccine, 8, pp. 536-542; Fehr, D., Holznagel, E., Bolla, S., Evaluation of the safety and efficacy of a modified live FIPV vaccine under field conditions (1995) Feline Pract, 23, pp. 83-88; Fehr, D., Holznagel, E., Bolla, S., Placebo-controlled evaluation of a modified life virus vaccine against feline infectious peritonitis: safety and efficacy under field conditions (1997) Vaccine, 15, pp. 1101-1109; Postorino Reeves, N., Vaccination against naturally occurring FIP in a single large cat shelter (1995) Feline Pract, 23, pp. 81-82; Addie, D.D., Jarrett, J.O., A study of naturally occurring feline coronavirus infections in kittens (1992) Vet Rec, 130, pp. 133-137; Kim, Y., Liu, H., Galasiti Kankanamalage, A.C., Reversal of the progression of fatal coronavirus infection in cats by a broad-spectrum coronavirus protease inhibitor (2016) PLoS Pathog, 12; Murphy, B.G., Perron, M., Murakami, E., The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies (2018) Vet Microbiol, 219, pp. 226-233; Pedersen, N.C., Kim, Y., Liu, H., Efficacy of a 3C-like protease inhibitor in treating various forms of acquired feline infectious peritonitis (2018) J Feline Med Surg, 20, pp. 378-392; Lutz, H., Gut, M., Leutenegger, C.M., Kinetics of FCoV infection in kittens born in catteries of high risk for FIP under different rearing conditions, , Second International Feline Coronavirus/Feline Infectious Peritonitis Symposium, 2002 August 4–7, Glasgow, UK; Pedersen, N.C., Sato, R., Foley, J.E., Common virus infections in cats, before and after being placed in shelters, with emphasis on feline enteric coronavirus (2004) J Feline Med Surg, 6, pp. 83-88","Addie, D.; Institute of Comparative Medicine, University of GlasgowUnited Kingdom; email: draddie@catvirus.com",,SAGE Publications Ltd,1098612X,,,31094626,English,J. Feline Med. Surg.,Article,Final,Open Access,Scopus,2-s2.0-85066844800,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Sun K., Chen J., Viboud C.",57215086759;57215086965;6701923799;,Early epidemiological analysis of the coronavirus disease 2019 outbreak based on crowdsourced data: a population-level observational study,2020,The Lancet Digital Health,2,4,,e201,e208,,4,10.1016/S2589-7500(20)30026-1,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079844271&doi=10.1016%2fS2589-7500%2820%2930026-1&partnerID=40&md5=c834123870ea0389a5274358108680e3,"Division of International Epidemiology and Population Studies, Fogarty International Center, US National Institutes of Health, Bethesda, MD, United States","Sun, K., Division of International Epidemiology and Population Studies, Fogarty International Center, US National Institutes of Health, Bethesda, MD, United States; Chen, J., Division of International Epidemiology and Population Studies, Fogarty International Center, US National Institutes of Health, Bethesda, MD, United States; Viboud, C., Division of International Epidemiology and Population Studies, Fogarty International Center, US National Institutes of Health, Bethesda, MD, United States","Background: As the outbreak of coronavirus disease 2019 (COVID-19) progresses, epidemiological data are needed to guide situational awareness and intervention strategies. Here we describe efforts to compile and disseminate epidemiological information on COVID-19 from news media and social networks. Methods: In this population-level observational study, we searched DXY.cn, a health-care-oriented social network that is currently streaming news reports on COVID-19 from local and national Chinese health agencies. We compiled a list of individual patients with COVID-19 and daily province-level case counts between Jan 13 and Jan 31, 2020, in China. We also compiled a list of internationally exported cases of COVID-19 from global news media sources (Kyodo News, The Straits Times, and CNN), national governments, and health authorities. We assessed trends in the epidemiology of COVID-19 and studied the outbreak progression across China, assessing delays between symptom onset, seeking care at a hospital or clinic, and reporting, before and after Jan 18, 2020, as awareness of the outbreak increased. All data were made publicly available in real time. Findings: We collected data for 507 patients with COVID-19 reported between Jan 13 and Jan 31, 2020, including 364 from mainland China and 143 from outside of China. 281 (55%) patients were male and the median age was 46 years (IQR 35–60). Few patients (13 [3%]) were younger than 15 years and the age profile of Chinese patients adjusted for baseline demographics confirmed a deficit of infections among children. Across the analysed period, delays between symptom onset and seeking care at a hospital or clinic were longer in Hubei province than in other provinces in mainland China and internationally. In mainland China, these delays decreased from 5 days before Jan 18, 2020, to 2 days thereafter until Jan 31, 2020 (p=0·0009). Although our sample captures only 507 (5·2%) of 9826 patients with COVID-19 reported by official sources during the analysed period, our data align with an official report published by Chinese authorities on Jan 28, 2020. Interpretation: News reports and social media can help reconstruct the progression of an outbreak and provide detailed patient-level data in the context of a health emergency. The availability of a central physician-oriented social network facilitated the compilation of publicly available COVID-19 data in China. As the outbreak progresses, social media and news reports will probably capture a diminishing fraction of COVID-19 cases globally due to reporting fatigue and overwhelmed health-care systems. In the early stages of an outbreak, availability of public datasets is important to encourage analytical efforts by independent teams and provide robust evidence to guide interventions. Funding: Fogarty International Center, US National Institutes of Health. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license",,adolescent; adult; age; aged; Article; awareness; child; China; coronavirus disease 2019; Coronavirus infection; crowdsourcing; data analysis; data base; demography; disease course; epidemic; female; government; health care system; help seeking behavior; human; information dissemination; information processing; major clinical study; male; mandatory reporting; mass medium; medical information; middle aged; observational study; population research; preschool child; school child; social media; social network; symptom; very elderly; young adult,"Statement on the second meeting of the International Health Regulations (2005) Emergency Committee regarding the outbreak of novel coronavirus (2019-nCoV) (2020), https://www.who.int/news-room/detail/30–01–2020-statement-on-the-second-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-outbreak-of-novel-coronavirus-(2019-ncov), World Health Organization Geneva (Accessed 10 February 2020); Rivers, C., Chretien, J.P., Riley, S., Using “outbreak science” to strengthen the use of models during epidemics (2019) Nat Commun, 10; Chowell, G., Bertozzi, S.M., Colchero, M.A., Severe respiratory disease concurrent with the circulation of H1N1 influenza (2009) N Engl J Med, 361, pp. 674-679; Chowell, G., Echevarría-Zuno, S., Viboud, C., Characterizing the epidemiology of the 2009 influenza A/H1N1 pandemic in Mexico (2011) PLoS Med, 8; Fraser, C., Donnelly, C.A., Cauchemez, S., Pandemic potential of a strain of influenza A (H1N1): early findings (2009) Science, 324, pp. 1557-1561; Lipsitch, M., Cohen, T., Cooper, B., Transmission dynamics and control of severe acute respiratory syndrome (2003) Science, 300, pp. 1966-1970; Cleaton, J.M., Viboud, C., Simonsen, L., Hurtado, A.M., Chowell, G., Characterizing Ebola transmission patterns based on internet news reports (2016) Clin Infect Dis, 62, pp. 24-31; DXY.cn; Pneumonia (2020), http://3g.dxy.cn/newh5/view/pneumonia, (in Chinese). (Accessed 10 February 2020); Global health data exchange (2020), ghdx.healthdata.org, Institute for Health Metrics and Evaluation Seattle, WA (Accessed 14 February 2020); Lemaitre, M., Carrat, F., Comparative age distribution of influenza morbidity and mortality during seasonal influenza epidemics and the 2009 H1N1 pandemic (2010) BMC Infect Dis, 10, p. 162; News/2019-nCoV (2020), https://www.imperial.ac.uk/mrc-global-infectious-disease-analysis/news–wuhan-coronavirus/, Imperial College London London (Accessed 10 February 2020); 2019 epidemic update and risk assessment of 2019 novel coronavirus (2020), http://www.chinacdc.cn/yyrdgz/202001/P020200128523354919292.pdf, China Center for Disease Control and Prevention Beijing (Accessed 10 February 2020); Backer, J.A., Klinkenberg, D., Wallinga, J., Incubation period of 2019 novel coronavirus (2019-nCoV) infections among travellers from Wuhan, China, 20–28 January 2020 (2020) Euro Surveill, 25; Lauer, S.A., Grantz, K.H., Bi, Q., The incubation period of 2019-nCoV from publicly reported confirmed cases: estimation and application (2020) medRxiv, , published online Feb 4. (preprint); Zhao, A., Ran, J., Musa, S.S., Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: a data-driven analysis in the early phase of the outbreak (2020) bioRxiv, , published online Jan 24. (preprint); Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med, , published online Jan 29; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, , published online Jan 24; Greenbaum, A.H., Chen, J., Reed, C., Hospitalizations for severe lower respiratory tract infections (2014) Pediatrics, 134, pp. 546-554; Chan, J.F., Yuan, S., Kok, K.H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, , published online Jan 24; Leung, G.M., Hedley, A.J., Ho, L.M., The epidemiology of severe acute respiratory syndrome in the 2003 Hong Kong epidemic: an analysis of all 1755 patients (2004) Ann Intern Med, 141, pp. 662-673; Simonsen, L., Spreeuwenberg, P., Lustig, R., Global mortality estimates for the 2009 Influenza Pandemic from the GLaMOR project: a modeling study (2013) PLoS Med, 10; Du, W., Wang, L., Cauchemez, S., Risk of 2019 novel coronavirus importations throughout China prior to the Wuhan quarantine (2020) medRxiv, , published online Feb 4. (preprint); Agua-Agum, J., Ariyarajah, A., Aylward, B., Exposure patterns driving ebola transmission in west Africa: A retrospective observational study (2016) PLoS Med, 13","Viboud, C.; Division of International Epidemiology and Population Studies, Fogarty International Center, US National Institutes of HealthUnited States; email: viboudc@mail.nih.gov",,Elsevier Ltd,25897500,,,,English,Lancet Digit. Heal.,Article,Final,Open Access,Scopus,2-s2.0-85079844271,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, [No author name available],[No author id available],As We Went to Press: COVID-19 Continues to Spread,2020,The American journal of nursing,120,4,,15,,,,10.1097/01.NAJ.0000659956.26994.75,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082561780&doi=10.1097%2f01.NAJ.0000659956.26994.75&partnerID=40&md5=fb4008b93dcd628e73aac4913649a1d7,,,Updates on the coronavirus.,,article; Coronavirinae; nonhuman,,,,NLM (Medline),15387488,,,32218028,English,Am J Nurs,Article,Final,Open Access,Scopus,2-s2.0-85082561780,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Paraskevis D., Kostaki E.G., Magiorkinis G., Panayiotakopoulos G., Sourvinos G., Tsiodras S.",57202611475;56463035500;13408749100;6507289427;7003879594;19337871400;,Full-genome evolutionary analysis of the novel corona virus (2019-nCoV) rejects the hypothesis of emergence as a result of a recent recombination event,2020,"Infection, Genetics and Evolution",79,,104212,,,,11,10.1016/j.meegid.2020.104212,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078675459&doi=10.1016%2fj.meegid.2020.104212&partnerID=40&md5=4316c28f32bf576206af3f9e38c2875e,"Department of Hygiene Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece; National Public Health Organization (NPHO), Athens, Greece; Laboratory of Clinical Virology, School of Medicine, University of Crete, Heraklion, Greece; Medical School, National and Kapodistrian University of Athens, Athens, Greece","Paraskevis, D., Department of Hygiene Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece; Kostaki, E.G., Department of Hygiene Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece; Magiorkinis, G., Department of Hygiene Epidemiology and Medical Statistics, Medical School, National and Kapodistrian University of Athens, Athens, Greece; Panayiotakopoulos, G., National Public Health Organization (NPHO), Athens, Greece; Sourvinos, G., Laboratory of Clinical Virology, School of Medicine, University of Crete, Heraklion, Greece; Tsiodras, S., Medical School, National and Kapodistrian University of Athens, Athens, Greece","Background: A novel coronavirus (2019-nCoV) associated with human to human transmission and severe human infection has been recently reported from the city of Wuhan in China. Our objectives were to characterize the genetic relationships of the 2019-nCoV and to search for putative recombination within the subgenus of sarbecovirus. Methods: Putative recombination was investigated by RDP4 and Simplot v3.5.1 and discordant phylogenetic clustering in individual genomic fragments was confirmed by phylogenetic analysis using maximum likelihood and Bayesian methods. Results: Our analysis suggests that the 2019-nCoV although closely related to BatCoV RaTG13 sequence throughout the genome (sequence similarity 96.3%), shows discordant clustering with the Bat_SARS-like coronavirus sequences. Specifically, in the 5′-part spanning the first 11,498 nucleotides and the last 3′-part spanning 24,341–30,696 positions, 2019-nCoV and RaTG13 formed a single cluster with Bat_SARS-like coronavirus sequences, whereas in the middle region spanning the 3′-end of ORF1a, the ORF1b and almost half of the spike regions, 2019-nCoV and RaTG13 grouped in a separate distant lineage within the sarbecovirus branch. Conclusions: The levels of genetic similarity between the 2019-nCoV and RaTG13 suggest that the latter does not provide the exact variant that caused the outbreak in humans, but the hypothesis that 2019-nCoV has originated from bats is very likely. We show evidence that the novel coronavirus (2019-nCov) is not-mosaic consisting in almost half of its genome of a distinct lineage within the betacoronavirus. These genomic features and their potential association with virus characteristics and virulence in humans need further attention. © 2020 Elsevier B.V.",Genomic sequence analysis; Molecular epidemiology; Novel coronavirus; Origin; Phylogenetic analysis; Recombination,"nucleotide; severe acute respiratory syndrome coronavirus 2; 2019 novel coronavirus; Article; bat; Bayes theorem; Coronavirinae; gene cluster; gene sequence; genetic recombination; maximum likelihood method; molecular evolution; molecular phylogeny; nonhuman; priority journal; sarbecovirus; SARS-related coronavirus; sequence homology; virus genome; Betacoronavirus; genetics; high throughput sequencing; phylogeny; Betacoronavirus; Genome, Viral; High-Throughput Nucleotide Sequencing; Phylogeny; Recombination, Genetic","Alagaili, A.N., Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia (2014) mBio, 5 (2). , e00884–14; World Health Organization, Annual review of diseases prioritized under the Research and Development Blueprint World Health Organization, Informal consultation, 6-7 February 2018, Geneva, Switzerland (2018); Babcock, G.J., Amino acids 270 to 510 of the severe acute respiratory syndrome coronavirus spike protein are required for interaction with receptor (2004) J. Virol., 78 (9), pp. 4552-4560; Cui, J., Li, F., Shi, Z.L., Origin and evolution of pathogenic coronaviruses (2019) Nat. Rev. Microbiol., 17 (3), pp. 181-192; Drosten, C., Identification of a novel coronavirus in patients with severe acute respiratory syndrome (2003) N. Engl. J. Med., 348 (20), pp. 1967-1976; ECDC, Risk assessment guidelines for infectious diseases transmitted on aircraft (RAGIDA) Middle East Respiratory Syndrome Coronavirus (MERS-CoV) (2020) ECDC Technical Report; Fehr, A.R., Perlman, S., Coronaviruses: an overview of their replication and pathogenesis (2015) Methods Mol. Biol., 1282, pp. 1-23; Guan, Y., Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China (2003) Science, 302 (5643), pp. 276-278; Hajjar, S.A., Memish, Z.A., McIntosh, K., Middle East Respiratory Syndrome Coronavirus (MERS-CoV): a perpetual challenge (2013) Ann. Saudi Med., 33 (5), pp. 427-436; Huelsenbeck, J.P., Ronquist, F., MRBAYES: Bayesian inference of phylogenetic trees (2001) Bioinformatics, 17 (8), pp. 754-755; Hui, D.S., The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health - the latest 2019 novel coronavirus outbreak in Wuhan, China (2020) Int. J. Infect. Dis., 91, pp. 264-266; Ithete, N.L., Close relative of human Middle East respiratory syndrome coronavirus in bat, South Africa (2013) Emerg. Infect. Dis., 19 (10), pp. 1697-1699; Ji, W., Homologous recombination within the spike glycoprotein of the newly identified coronavirus may boost cross-species transmission from snake to human (2020) Int. J. Infect. Dis., 91, pp. 264-266; Kahn, J.S., McIntosh, K., History and recent advances in coronavirus discovery (2005) Pediatr. Infect. Dis. J., 24 (11). , p. S223–7, discussion S226; Katoh, K., Standley, D.M., MAFFT multiple sequence alignment software version 7: improvements in performance and usability (2013) Mol. Biol. Evol., 30 (4), pp. 772-780; Ksiazek, T.G., A novel coronavirus associated with severe acute respiratory syndrome (2003) N. Engl. J. Med., 348 (20), pp. 1953-1966; Lau, S.K., Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats (2005) Proc. Natl. Acad. Sci. U. S. A., 102 (39), pp. 14040-14045; Li, W., Bats are natural reservoirs of SARS-like coronaviruses (2005) Science, 310 (5748), pp. 676-679; Li, W., Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2 (2005) EMBO J., 24 (8), pp. 1634-1643; Lole, K.S., Full-length human immunodeficiency virus type 1 genomes from subtype C-infected seroconverters in India, with evidence of intersubtype recombination (1999) J. Virol., 73 (1), pp. 152-160; Magiorkinis, G., Phylogenetic analysis of the full-length SARS-CoV sequences: evidence for phylogenetic discordance in three genomic regions (2004) J. Med. Virol., 74 (3), pp. 369-372; Martin, D.P., RDP4: detection and analysis of recombination patterns in virus genomes (2015) Virus Evol., 1 (1). , p. vev003; Paules, C.I., Marston, H.D., Fauci, A.S., Coronavirus infections-more than just the common cold (2020) JAMA; Peiris, J.S., Coronavirus as a possible cause of severe acute respiratory syndrome (2003) Lancet, 361 (9366), pp. 1319-1325; Perlman, S., Another decade, another coronavirus (2020) N. Engl. J. Med.; Stecher, G., Tamura, K., Kumar, S., Molecular evolutionary genetics analysis (MEGA) for macOS (2020) Mol. Biol. Evol., , pii: msz312; Swofford, D.L., PAUP*. Phylogenetic Analysis Using Parsimony (*and Other Methods). Version 4 (2003), Sinauer Associates Sunderland, Massachusetts; World Health Organization, Novel Coronavirus (2019-nCoV) Situation report- 5, 25 January 2020. Geneva, Switzerland (2020); Zaki, A.M., Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia (2012) N. Engl. J. Med., 367 (19), pp. 1814-1820; Zhou, P., Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin (2020) bioRxiv, , p. 2020.01.22.914952; Zhu, N., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med","Paraskevis, D.; Department of Hygiene, Epidemiology and Medical Statistics, Medical School, University of Athens, 75 Mikras Asias Street, Greece; email: dparask@med.uoa.gr",,Elsevier B.V.,15671348,,IGENC,32004758,English,Infec. Genet. Evol.,Article,Final,Open Access,Scopus,2-s2.0-85078675459,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Fricker R.D., Jr., Rigdon S.E.",57216029813;6701330065;,Investigating a disease outbreak,2020,Significance,17,2,,14,,,,10.1111/1740-9713.01372,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082406420&doi=10.1111%2f1740-9713.01372&partnerID=40&md5=194f39ffb4224f54e652073dc2fcef2b,"Virginia Tech Department of Statistics, United States; Department of Epidemiology and Biostatistics, College for Public Health Social Justice, Saint Louis University, United States; Department of Mathematics and Statistics, Southern Illinois University Edwardsville, United States","Fricker, R.D., Jr., Virginia Tech Department of Statistics, United States; Rigdon, S.E., Department of Epidemiology and Biostatistics, College for Public Health Social Justice, Saint Louis University, United States, Department of Mathematics and Statistics, Southern Illinois University Edwardsville, United States","Teams of epidemiological and medical “detectives” are working to get a coronavirus pandemic under control. Ronald D. Fricker, Jr and Steven E. Rigdon walk us through a typical investigation. © 2020 The Royal Statistical Society",,,,,,Blackwell Publishing Ltd,17409705,,,,English,Significance,Note,Final,Open Access,Scopus,2-s2.0-85082406420,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhang H.-W., Yu J., Xu H.-J., Lei Y., Pu Z.-H., Dai W.-C., Lin F., Wang Y.-L., Wu X.-L., Liu L.-H., Li M., Mo Y.-Q., Zhang H., Luo S.-P., Chen H., Lyu G.-W., Zhou Z.-G., Liu W.-M., Liu X.-L., Song H.-Y., Chen F.-Z., Zeng L., Zhong H., Guo T.-T., Hu Y.-Q., Yang X.-X., Liu P.-N., Li D.-F.",57213146402;57214595253;57215185682;55697963800;57213861928;57214801032;30967625100;57191421482;57215200822;57215196147;57215190991;57215190274;57214095225;57215200201;57215205051;57193258147;57215196111;57215193980;57191420284;57215199564;57215207002;57215193259;57215209646;57215201625;57215186144;57215207359;56299470400;57215194831;,Corona Virus International Public Health Emergencies: Implications for Radiology Management,2020,Academic Radiology,27,4,,463,467,,1,10.1016/j.acra.2020.02.003,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080026376&doi=10.1016%2fj.acra.2020.02.003&partnerID=40&md5=3450b9ceb9976d426f8a44453e55d8bd,"Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, 3002 SunGangXi Road, Shenzhen, 518035, China","Zhang, H.-W., Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, 3002 SunGangXi Road, Shenzhen, 518035, China; Yu, J., Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, 3002 SunGangXi Road, Shenzhen, 518035, China; Xu, H.-J., Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, 3002 SunGangXi Road, Shenzhen, 518035, China; Lei, Y., Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, 3002 SunGangXi Road, Shenzhen, 518035, China; Pu, Z.-H., Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, 3002 SunGangXi Road, Shenzhen, 518035, China; Dai, W.-C., Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, 3002 SunGangXi Road, Shenzhen, 518035, China; Lin, F., Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, 3002 SunGangXi Road, Shenzhen, 518035, China; Wang, Y.-L., Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, 3002 SunGangXi Road, Shenzhen, 518035, China; Wu, X.-L., Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, 3002 SunGangXi Road, Shenzhen, 518035, China; Liu, L.-H., Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, 3002 SunGangXi Road, Shenzhen, 518035, China; Li, M., Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, 3002 SunGangXi Road, Shenzhen, 518035, China; Mo, Y.-Q., Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, 3002 SunGangXi Road, Shenzhen, 518035, China; Zhang, H., Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, 3002 SunGangXi Road, Shenzhen, 518035, China; Luo, S.-P., Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, 3002 SunGangXi Road, Shenzhen, 518035, China; Chen, H., Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, 3002 SunGangXi Road, Shenzhen, 518035, China; Lyu, G.-W., Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, 3002 SunGangXi Road, Shenzhen, 518035, China; Zhou, Z.-G., Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, 3002 SunGangXi Road, Shenzhen, 518035, China; Liu, W.-M., Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, 3002 SunGangXi Road, Shenzhen, 518035, China; Liu, X.-L., Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, 3002 SunGangXi Road, Shenzhen, 518035, China; Song, H.-Y., Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, 3002 SunGangXi Road, Shenzhen, 518035, China; Chen, F.-Z., Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, 3002 SunGangXi Road, Shenzhen, 518035, China; Zeng, L., Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, 3002 SunGangXi Road, Shenzhen, 518035, China; Zhong, H., Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, 3002 SunGangXi Road, Shenzhen, 518035, China; Guo, T.-T., Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, 3002 SunGangXi Road, Shenzhen, 518035, China; Hu, Y.-Q., Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, 3002 SunGangXi Road, Shenzhen, 518035, China; Yang, X.-X., Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, 3002 SunGangXi Road, Shenzhen, 518035, China; Liu, P.-N., Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, 3002 SunGangXi Road, Shenzhen, 518035, China; Li, D.-F., Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, 3002 SunGangXi Road, Shenzhen, 518035, China","The outbreak of 2019 novel coronavirus (2019-nCoV) pneumonia was reported in Wuhan, Hubei Province, China in December 2019 and has spread internationally. This article discusses how radiology departments can most effectively respond to this public health emergency. © 2020 The Association of University Radiologists",2019-nCoV; COVID-19; PHEIC; radiology management; WHO,"Article; clinical classification; clinical effectiveness; clinical examination; computer assisted tomography; contact isolation; Coronavirinae; coronavirus disease 2019; Coronavirus infection; emergency care; hand washing; human; infection prevention; managed care; pneumonia; priority journal; public health; radiology; radiology department; treatment response time; Betacoronavirus; China; diagnostic imaging; emergency; epidemic; epidemiology; lung; virus pneumonia; x-ray computed tomography; Betacoronavirus; China; Coronavirus Infections; Disease Outbreaks; Emergencies; Humans; Lung; Pneumonia, Viral; Public Health; Radiology; Tomography, X-Ray Computed","Wang, W., Tang, J., Wei, F., Updated understanding of the outbreak of 2019 novel coronavirus (2019-nCoV) in Wuhan (2020) China J Med Virol; Bassetti, M., Vena, A., Roberto Giacobbe, D., The Novel Chinese Coronavirus (2019-nCoV) infections: challenges for fighting the storm (2020) Eur J Clin Invest; Lu, H., Stratton, C.W., Tang, Y.W., Outbreak of pneumonia of unknown etiology in Wuhan China: the mystery and the miracle (2020) J Med Virol; Corman, V.M., Landt, O., Kaiser, M., Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR (2020) Euro Surveill, 25 (3); Yoo, J.H., The fight against the 2019-nCoV outbreak: an Arduous March has just begun (2020) J Korean Med Sci, 35 (4), p. e56; Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382, pp. 727-733; Zhao, S., Lin, Q., Ran, J., Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: a data-driven analysis in the early phase of the outbreak (2020) Int J Infect Dis; Wan, Y., Shang, J., Graham, R., Receptor recognition by novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS (2020) J Virol","Lei, Y.; Department of Radiology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, 3002 SunGangXi Road, China; email: 13602658583@163.com",,Elsevier USA,10766332,,ARADF,32113880,English,Acad. Radiol.,Article,Final,Open Access,Scopus,2-s2.0-85080026376,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Xu Y.,57215633329;,Unveiling the Origin and Transmission of 2019-nCoV,2020,Trends in Microbiology,28,4,,239,240,,1,10.1016/j.tim.2020.02.001,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079900882&doi=10.1016%2fj.tim.2020.02.001&partnerID=40&md5=a2602372c957e36b9fef7177497afc26,"Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom","Xu, Y., Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom","A novel coronavirus has caused thousands of human infections in China since December 2019, raising a global public health concern. Recent studies (Huang et al., Chan et al., and Zhou et al.) have provided timely insights into its origin and ability to spread among humans, informing infection prevention and control practices. © 2020 Elsevier Ltd",2019-nCoV; human-to-human transmission; interspecies transmission; pneumonia; public health,"China; Coronavirinae; coronavirus disease 2019; Coronavirus infection; eating habit; epidemic; epidemiological monitoring; feeding behavior; gene mutation; genetic recombination; genetic variability; genome analysis; high risk population; human; illness trajectory; infection control; infection prevention; infection risk; nonhuman; prevalence; priority journal; public health problem; risk reduction; severe acute respiratory syndrome coronavirus 2; Short Survey; virus detection; virus gene; virus transmission; virus virulence; animal; bat; Betacoronavirus; Coronavirus infection; genetics; livestock; Melia azedarach; Middle East respiratory syndrome coronavirus; pathogenicity; public health; SARS coronavirus; virus pneumonia; zoonosis; coronavirus spike glycoprotein; COVID-19; severe acute respiratory syndrome coronavirus 2; Animals; Betacoronavirus; Chiroptera; Coronavirus Infections; Disease Outbreaks; Humans; Livestock; Melia azedarach; Middle East Respiratory Syndrome Coronavirus; Pneumonia, Viral; Public Health; SARS Virus; Spike Glycoprotein, Coronavirus; Zoonoses","WHO, Novel coronavirus (2019-nCoV) situation reports (2020), https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports/, World Health Organisation; Huang, C., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506; Chan, J.F.-W., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, 395, pp. 514-523; Zhou, P., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature, , Published online February 3, 2020; Lu, G., Bat-to-human: spike features determining 'host jump' of coronaviruses SARS-CoV, MERS-CoV, and beyond (2015) Trends Microbiol., 23, pp. 468-478; Li, W., Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus (2003) Nature, 426, pp. 450-454; Cui, J., Origin and evolution of pathogenic coronaviruses (2019) Nat. Rev. Microbiol., 17, pp. 181-192; Su, S., Epidemiology, genetic recombination, and pathogenesis of coronaviruses (2016) Trends Microbiol., 24, pp. 490-502; Pan, Y., Discovery of a novel swine enteric alphacoronavirus (SeACoV) in southern China (2017) Vet. Microbiol., 211, pp. 15-21","Xu, Y.; Nuffield Department of Medicine, University of OxfordUnited Kingdom; email: yifei.xu@ndm.ox.ac.uk",,Elsevier Ltd,0966842X,,TRMIE,32155431,English,Trends Microbiol.,Short Survey,Final,Open Access,Scopus,2-s2.0-85079900882,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhang N., Wang L., Deng X., Liang R., Su M., He C., Hu L., Su Y., Ren J., Yu F., Du L., Jiang S.",56167373100;57201266398;57215206812;57205172266;57215071930;57205167774;57214788613;57214941395;57214675030;57085672500;8686996200;56491898300;,Recent advances in the detection of respiratory virus infection in humans,2020,Journal of Medical Virology,92,4,,408,417,,13,10.1002/jmv.25674,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078826093&doi=10.1002%2fjmv.25674&partnerID=40&md5=af264f7a2267556f98f8d69ac75c9e88,"Department of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou, China; State Key Laboratory of North China Crop Improvement and Regulation, Research Center of Chinese Jujube, Hebei Agricultural University, Baoding, China; State Key Laboratory of North China Crop Improvement and Regulation, College of Life and Science, Hebei Agricultural University, Baoding, China; Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, United States; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China","Zhang, N., Department of Clinical Medicine, School of Medicine, Zhejiang University City College, Hangzhou, China; Wang, L., State Key Laboratory of North China Crop Improvement and Regulation, Research Center of Chinese Jujube, Hebei Agricultural University, Baoding, China; Deng, X., State Key Laboratory of North China Crop Improvement and Regulation, College of Life and Science, Hebei Agricultural University, Baoding, China; Liang, R., State Key Laboratory of North China Crop Improvement and Regulation, College of Life and Science, Hebei Agricultural University, Baoding, China; Su, M., State Key Laboratory of North China Crop Improvement and Regulation, College of Life and Science, Hebei Agricultural University, Baoding, China; He, C., State Key Laboratory of North China Crop Improvement and Regulation, College of Life and Science, Hebei Agricultural University, Baoding, China; Hu, L., State Key Laboratory of North China Crop Improvement and Regulation, College of Life and Science, Hebei Agricultural University, Baoding, China; Su, Y., State Key Laboratory of North China Crop Improvement and Regulation, College of Life and Science, Hebei Agricultural University, Baoding, China; Ren, J., State Key Laboratory of North China Crop Improvement and Regulation, College of Life and Science, Hebei Agricultural University, Baoding, China; Yu, F., State Key Laboratory of North China Crop Improvement and Regulation, College of Life and Science, Hebei Agricultural University, Baoding, China; Du, L., Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, United States; Jiang, S., Lindsley F. Kimball Research Institute, New York Blood Center, New York, NY, United States, Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China","Respiratory tract viral infection caused by viruses or bacteria is one of the most common diseases in human worldwide, while those caused by emerging viruses, such as the novel coronavirus, 2019-nCoV that caused the pneumonia outbreak in Wuhan, China most recently, have posed great threats to global public health. Identification of the causative viral pathogens of respiratory tract viral infections is important to select an appropriate treatment, save people's lives, stop the epidemics, and avoid unnecessary use of antibiotics. Conventional diagnostic tests, such as the assays for rapid detection of antiviral antibodies or viral antigens, are widely used in many clinical laboratories. With the development of modern technologies, new diagnostic strategies, including multiplex nucleic acid amplification and microarray-based assays, are emerging. This review summarizes currently available and novel emerging diagnostic methods for the detection of common respiratory viruses, such as influenza virus, human respiratory syncytial virus, coronavirus, human adenovirus, and human rhinovirus. Multiplex assays for simultaneous detection of multiple respiratory viruses are also described. It is anticipated that such data will assist researchers and clinicians to develop appropriate diagnostic strategies for timely and effective detection of respiratory virus infections. © 2020 Wiley Periodicals, Inc.",adenovirus; coronavirus; diagnostic methods; influenza virus; respiratory syncytial virus; respiratory viral infection; rhinovirus,"DNA; quantum dot; Coronavirinae; diagnostic procedure; DNA microarray; enzyme linked immunosorbent assay; high throughput sequencing; human; Human adenovirus C; Human respiratory syncytial virus; Human rhinovirus; immunoassay; immunofluorescence test; Influenza virus; intermethod comparison; lateral flow immunoassay; limit of detection; limit of quantitation; molecular diagnosis; multiplex polymerase chain reaction; multiplex real time polymerase chain reaction; nonhuman; Qiagen ResPlex II V2.0; real time polymerase chain reaction; real time reverse transcription polymerase chain reaction; reproducibility; reverse transcription loop mediated isothermal amplification; Review; semi-nested polymerase chain reaction; sensitivity and specificity; viral respiratory tract infection; virus detection; virus isolation; Coronavirus infection; growth, development and aging; human adenovirus infection; immunological procedures; influenza; isolation and purification; nucleic acid amplification; picornavirus infection; respiratory syncytial virus infection; respiratory tract infection; Rhinovirus; virus; Adenovirus Infections, Human; Coronavirus Infections; Humans; Immunoassay; Immunologic Tests; Influenza, Human; Multiplex Polymerase Chain Reaction; Nucleic Acid Amplification Techniques; Picornaviridae Infections; Real-Time Polymerase Chain Reaction; Respiratory Syncytial Virus Infections; Respiratory Tract Infections; Rhinovirus; Viruses","Mahony, J.B., Petrich, A., Smieja, M., Molecular diagnosis of respiratory virus infections (2011) Crit Rev Clin Lab Sci, 48, pp. 217-249; Azar, M.M., Landry, M.L., Detection of influenza A and B viruses and respiratory syncytial virus by use of Clinical Laboratory Improvement Amendments of 1988 (CLIA)-waived point-of-care assays: a paradigm shift to molecular tests (2018) J Clin Microbiol, 56; Fendrick, A.M., Monto, A.S., Nightengale, B., Sarnes, M., The economic burden of non-influenza-related viral respiratory tract infection in the United States (2003) Arch Intern Med, 163, pp. 487-494; Hu, B., Ge, X., Wang, L.F., Shi, Z., Bat origin of human coronaviruses (2015) Virol J, 12, p. 221; Vemula, S.V., Zhao, J., Liu, J., Wang, X., Biswas, S., Hewlett, I., Current approaches for diagnosis of influenza virus infections in humans (2016) Viruses, 8, p. 96; Zhang, P., Vemula, S.V., Zhao, J., A highly sensitive europium nanoparticle-based immunoassay for detection of influenza A/B virus antigen in clinical specimens (2014) J Clin Microbiol, 52, pp. 4385-4387; Trombetta, V.K., Chan, Y.L., Bankowski, M.J., Are rapid influenza antigen tests still clinically useful in today's molecular diagnostics world? 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State Key Laboratory of North China Crop Improvement and Regulation, College of Life and Science, Hebei Agricultural UniversityChina; email: shmyf@hebau.edu.cn",,John Wiley and Sons Inc.,1466615,,JMVID,31944312,English,J. Med. Virol.,Review,Final,Open Access,Scopus,2-s2.0-85078826093,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Habibzadeh F., Lang T.",55984521500;57216086249;,"The Coronavirus Pandemic: ""The Show Must NOT Go On""",2020,The international journal of occupational and environmental medicine,11,2,,63,64,,,10.34172/ijoem.2020.1979,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082562095&doi=10.34172%2fijoem.2020.1979&partnerID=40&md5=89290acf4ce085e90db2bc6462aa0231,"The IJOEM; Tom Lang Communications and Training International, Kirkland, WA, USA","Habibzadeh, F., The IJOEM; Lang, T., Tom Lang Communications and Training International, Kirkland, WA, USA",[No abstract available],Coronavirus; COVID-19; Pandemic; SARS-CoV-2; Social distancing,,,,,NLM (Medline),20086814,,,32218554,English,Int J Occup Environ Med,Editorial,Final,,Scopus,2-s2.0-85082562095,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Gorbalenya A.E., Baker S.C., Baric R.S., de Groot R.J., Drosten C., Gulyaeva A.A., Haagmans B.L., Lauber C., Leontovich A.M., Neuman B.W., Penzar D., Perlman S., Poon L.L.M., Samborskiy D.V., Sidorov I.A., Sola I., Ziebuhr J., Coronaviridae Study Group of the International Committee on Taxonomy of Viruses",7005626044;7403307881;57205312930;7103077066;7003813990;56841599800;6701371301;57205045581;23985202000;8263558000;57200541433;57204567845;57216111018;35729042500;7005186545;7003336781;7003783935;,The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2,2020,Nature Microbiology,5,4,,536,544,,,10.1038/s41564-020-0695-z,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082561475&doi=10.1038%2fs41564-020-0695-z&partnerID=40&md5=e936cafbf9bb740e00087fa694e421ed,"Department of Medical Microbiology, Leiden University Medical Center, Leiden, Netherlands; Faculty of Bioengineering and Bioinformatics and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russian Federation; Department of Microbiology and Immunology, Loyola University of Chicago, Stritch School of Medicine, Maywood, IL, United States; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, United States; Division of Virology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands; Institute of Virology, Charité – Universitätsmedizin Berlin, Berlin, Germany; Viroscience Lab, Erasmus MC, Rotterdam, Netherlands; Texas A&M University-Texarkana, Texarkana, TX, United States; Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, United States; Centre of Influenza Research & School of Public Health, The University of Hong Kong, Hong Kong, China; Department of Molecular and Cell Biology, National Center of Biotechnology (CNB-CSIC), Campus de Cantoblanco, Madrid, Spain; Institute of Medical Virology, Justus Liebig University Giessen, Giessen, Germany; Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands","Gorbalenya, A.E., Department of Medical Microbiology, Leiden University Medical Center, Leiden, Netherlands, Faculty of Bioengineering and Bioinformatics and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russian Federation, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands; Baker, S.C., Department of Microbiology and Immunology, Loyola University of Chicago, Stritch School of Medicine, Maywood, IL, United States; Baric, R.S., Department of Epidemiology, University of North Carolina, Chapel Hill, NC, United States; de Groot, R.J., Division of Virology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands; Drosten, C., Institute of Virology, Charité – Universitätsmedizin Berlin, Berlin, Germany; Gulyaeva, A.A., Department of Medical Microbiology, Leiden University Medical Center, Leiden, Netherlands; Haagmans, B.L., Viroscience Lab, Erasmus MC, Rotterdam, Netherlands; Lauber, C., Department of Medical Microbiology, Leiden University Medical Center, Leiden, Netherlands; Leontovich, A.M., Faculty of Bioengineering and Bioinformatics and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russian Federation; Neuman, B.W., Texas A&M University-Texarkana, Texarkana, TX, United States; Penzar, D., Faculty of Bioengineering and Bioinformatics and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russian Federation; Perlman, S., Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, United States; Poon, L.L.M., Centre of Influenza Research & School of Public Health, The University of Hong Kong, Hong Kong, China; Samborskiy, D.V., Faculty of Bioengineering and Bioinformatics and Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russian Federation; Sidorov, I.A., Department of Medical Microbiology, Leiden University Medical Center, Leiden, Netherlands; Sola, I., Department of Molecular and Cell Biology, National Center of Biotechnology (CNB-CSIC), Campus de Cantoblanco, Madrid, Spain; Ziebuhr, J., Institute of Medical Virology, Justus Liebig University Giessen, Giessen, Germany; Coronaviridae Study Group of the International Committee on Taxonomy of Viruses",[No abstract available],,,"Krammer, F., Influenza (2018) Nat. Rev. Dis. Primers, 4, p. 3; Zheng, D.P., Norovirus classification and proposed strain nomenclature (2006) Virology, 346, pp. 312-323; Wu, A., Genome composition and divergence of the novel coronavirus (2019-nCoV) originating in China (2020) Cell Host Microbe, , https://doi.org/10.1016/j.chom.2020.02.001; Adams, M.J., 50 years of the International Committee on Taxonomy of Viruses: progress and prospects (2017) Arch. Virol., 162, pp. 1441-1446; Gorbalenya, A.E., Lauber, C., Siddell, S., Taxonomy of Viruses (2019) Reference Module in Biomedical Sciences, , https://doi.org/10.1016/B978-0-12-801238-3.99237-7, Elsevier; Van Regenmortel, M.H., Maniloff, J., Calisher, C., The concept of virus species (1991) Arch. Virol., 120, pp. 313-314; (2018) The International Code of Virus Classification and Nomenclature, , https://talk.ictvonline.org/information/w/ictv-information/383/ictv-code; Masters, P.S., The molecular biology of coronaviruses (2006) Adv. Virus Res., 66, pp. 193-292; Perlman, S., Netland, J., Coronaviruses post-SARS: update on replication and pathogenesis (2009) Nat. Rev. Microbiol., 7, pp. 439-450; Drosten, C., Identification of a novel coronavirus in patients with severe acute respiratory syndrome (2003) N. Engl. J. Med., 348, pp. 1967-1976; Ksiazek, T.G., A novel coronavirus associated with severe acute respiratory syndrome (2003) N. Engl. J. Med., 348, pp. 1953-1966; Peiris, J.S.M., Coronavirus as a possible cause of severe acute respiratory syndrome (2003) Lancet, 361, pp. 1319-1325; Zumla, A., Hui, D.S., Perlman, S., Middle East respiratory syndrome (2015) Lancet, 386, pp. 995-1007; Zaki, A.M., van Boheemen, S., Bestebroer, T.M., Osterhaus, A.D.M.E., Fouchier, R.A.M., Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia (2012) N. Engl. J. 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Reorganization of the Family Coronaviridae into Two Families, Coronaviridae (Including the Current Subfamily Coronavirinae and the New Subfamily Letovirinae) and the New Family Tobaniviridae (Accommodating the Current Subfamily Torovirinae and Three Other Subfamilies), Revision of the Genus Rank Structure and Introduction of a New Subgenus Rank, , https://ictv.global/proposal/2017.Nidovirales/, ICTV; Ziebuhr, J., (2019) Proposal 2019.021S.Ac.v1. Create ten new species and a new genus in the subfamily Orthocoronavirinae of the family Coronaviridae and five new species and a new genus in the subfamily Serpentovirinae of the family Tobaniviridae, , https://ictv.global/proposal/2019.Nidovirales/, ICTV; de Groot, R.J., (2012) Virus Taxonomy, Ninth Report of the International Committee on Taxonomy of Viruses, pp. 806-828. , (eds King, A. M. 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Virol., 158, pp. 301-311; Forni, D., Cagliani, R., Clerici, M., Sironi, M., Molecular evolution of human coronavirus genomes (2017) Trends Microbiol., 25, pp. 35-48; Nijhuis, R.H.T., PCR assays for detection of human astroviruses: In silico evaluation and design, and in vitro application to samples collected from patients in the Netherlands (2018) J. Clin. Virol., 108, pp. 83-89; Siddell, S.G., Binomial nomenclature for virus species: a consultation (2020) Arch. Virol., 165, pp. 519-525; Gorbalenya, A.E., Practical application of bioinformatics by the multidisciplinary VIZIER consortium (2010) Antiviral Res., 87, pp. 95-110; Nguyen, L.T., Schmidt, H.A., von Haeseler, A., Minh, B.Q., IQ-TREE: a fast and effective stochastic algorithm for estimating maximum-likelihood phylogenies (2015) Mol. Biol. Evol., 32, pp. 268-274; Rivers, T.M., Filterable viruses: a critical review (1927) J. Bacteriol., 14, pp. 217-258; Carroll, D., The global virome project (2018) Science, 359, pp. 872-874; Zhang, Y.-Z., Chen, Y.-M., Wang, W., Qin, X.-C., Holmes, E.C., Expanding the RNA virosphere by unbiased metagenomics (2019) Annu. Rev. Virol., 6, pp. 119-139; (2018), World Health Organization; Corman, V.M., Muth, D., Niemeyer, D., Drosten, C., Hosts and sources of endemic human coronaviruses (2018) Adv. Virus Res., 100, pp. 163-188; González, J.M., Gomez-Puertas, P., Cavanagh, D., Gorbalenya, A.E., Enjuanes, L., A comparative sequence analysis to revise the current taxonomy of the family Coronaviridae (2003) Arch. Virol., 148, pp. 2207-2235; Saberi, A., Gulyaeva, A.A., Brubacher, J.L., Newmark, P.A., Gorbalenya, A.E., A planarian nidovirus expands the limits of RNA genome size (2018) PLoS Pathog., 14; Lai, M.M.C., Recombination in large RNA viruses: Coronaviruses (1996) Semin. Virol., 7, pp. 381-388; Luk, H.K.H., Li, X., Fung, J., Lau, S.K.P., Woo, P.C.Y., Molecular epidemiology, evolution and phylogeny of SARS coronavirus (2019) Infect. Genet. Evol., 71, pp. 21-30; Tao, Y., Surveillance of bat coronaviruses in Kenya identifies relatives of human coronaviruses NL63 and 229E and their recombination history (2017) J. Virol., 91, pp. e01953-e1916; Tao, Y., Tong, S.X., Complete genome sequence of a severe acute respiratory syndrome-related coronavirus from Kenyan bats (2019) Microbiol. Resour. Ann., 8, pp. e00548-e519; Hu, B., Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus (2017) PLoS Pathog., 13; Holmes, E.C., Rambaut, A., Viral evolution and the emergence of SARS coronavirus (2004) Philos. T. R. Soc. B, 359, pp. 1059-1065; Hon, C.C., Evidence of the recombinant origin of a bat severe acute respiratory syndrome (SARS)-like coronavirus and its implications on the direct ancestor of SARS coronavirus (2008) J. Virol., 82, pp. 1819-1826","Gorbalenya, A.E.; Department of Biomedical Data Sciences, Leiden University Medical CenterNetherlands",,Nature Research,20585276,,,32123347,English,Nat. Microbiol.,Review,Final,Open Access,Scopus,2-s2.0-85082561475,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Purcell L.N., Charles A.G.",57195480992;57201592720;,An Invited Commentary on “World Health Organization declares global emergency: A review of the 2019 novel Coronavirus (COVID-19)”: Emergency or new reality?,2020,International Journal of Surgery,76,,,111,,,,10.1016/j.ijsu.2020.03.002,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082310492&doi=10.1016%2fj.ijsu.2020.03.002&partnerID=40&md5=804c9372b39dd89f1c8c8d41422b6224,"Department of Surgery, University of North Carolina at Chapel Hill, UNC School of Medicine, 4008 Burnett Womack BuildingCB 7228, United States","Purcell, L.N., Department of Surgery, University of North Carolina at Chapel Hill, UNC School of Medicine, 4008 Burnett Womack BuildingCB 7228, United States; Charles, A.G., Department of Surgery, University of North Carolina at Chapel Hill, UNC School of Medicine, 4008 Burnett Womack BuildingCB 7228, United States",[No abstract available],,,"Wu, Z., McGoogan, J.M., Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention [published online ahead of print, 2020 Feb 24] (2020) JAMA, , 10.1001/jama.2020.2648; Sohrabi, C., Alisafi, Z., O'Neill, N., Khan, M., Kerwan, A., Al-Jabir, A., Iosifidis, C., Agha, R., World health organization declares global emergency: a review of the 2019 novel Coronavirus (COVID-19) (2020) Int. J. Surg., 76, pp. 71-76; World Health Organization, WHO Emergency Committee Statement on the Second Meeting of the International Health Regulations (2005) Emergency Committee Regarding the Outbreak of Novel Coronavirus (COVID-19) (2020), https://www.who.int/news-room/detail/30-01-2020-statement-on-the-second-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-outbreak-of-novel-coronavirus-(COVID-19), WHO Geneva; Gilbert, M., Pullano, G., Pinotti, F., Valdano, E., Poletto, C., Boëlle, P.Y., D'Ortenzio, E., Gutierrez, B., Preparedness and vulnerability of African countries against importations of COVID-19: a modelling study (2020) Lancet, , S0140-6736(20)30411-6; Sambala, E.Z., Kanyenda, T., Iwu, C.J., Iwu, C.D., Jaca, A., Wiysonge, C.S., Pandemic influenza preparedness in the WHO African region: are we ready yet? (2018) BMC Infect. Dis., 18 (1), p. 567","Charles, A.G.; Department of Surgery, University of North Carolina at Chapel Hill, UNC School of Medicine, 4008 Burnett Womack Building, United States; email: anthchar@med.unc.edu",,Elsevier Ltd,17439191,,,32169565,English,Int. J. Surg.,Letter,Final,Open Access,Scopus,2-s2.0-85082310492,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Fadel M., Salomon J., Descatha A.",57195502355;7102539618;6506111339;,Coronavirus outbreak: the role of companies in preparedness and responses,2020,The Lancet Public Health,5,4,,e193,,,,10.1016/S2468-2667(20)30051-7,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082197985&doi=10.1016%2fS2468-2667%2820%2930051-7&partnerID=40&md5=f9c12b5c924382e52bb835799d4db2ef,"University of Angers, Centre Hospitalier Universitaire d'Angers, Université de Rennes, INSERM, School of Public Health, Institut de recherche en santé, environnement et travail—UMR_S1085, CAPTV-CDC, Angers, F49000, France; Paris Hospital (AP-HP) Occupational Health Unit, Poincaré University Hospital, Paris, France; Versailles Saint Quentin-en-Yvelines University, INSERM, UMR 1181, Institut Pasteur, Paris, France; AP-HP, Department of Acute Medicine, CHU PIFO, Poincaré Hospital, Paris, France; General Director for Health, Ministry of Solidarities and Health, Paris, France","Fadel, M., University of Angers, Centre Hospitalier Universitaire d'Angers, Université de Rennes, INSERM, School of Public Health, Institut de recherche en santé, environnement et travail—UMR_S1085, CAPTV-CDC, Angers, F49000, France, Paris Hospital (AP-HP) Occupational Health Unit, Poincaré University Hospital, Paris, France; Salomon, J., Versailles Saint Quentin-en-Yvelines University, INSERM, UMR 1181, Institut Pasteur, Paris, France, AP-HP, Department of Acute Medicine, CHU PIFO, Poincaré Hospital, Paris, France, General Director for Health, Ministry of Solidarities and Health, Paris, France; Descatha, A., University of Angers, Centre Hospitalier Universitaire d'Angers, Université de Rennes, INSERM, School of Public Health, Institut de recherche en santé, environnement et travail—UMR_S1085, CAPTV-CDC, Angers, F49000, France, Paris Hospital (AP-HP) Occupational Health Unit, Poincaré University Hospital, Paris, France",[No abstract available],,2019 novel coronavirus; Coronavirinae; coronavirus disease 2019; emergency response time; follow up; government; health practitioner; health service; human; Letter; occupational health; occupational safety; organization; priority journal; psychological aspect; public health; social psychology; training; virus infection,"Occupational safety and health in public health emergencies: a manual for protecting health workers and responders (2018), https://www.who.int/occupational_health/publications/safety-health-public-health-emergencies/en/, (Accessed 21 February 2020); Plan Pandemie grippale https://www.gouvernement.fr/risques/plan-pandemie-grippale, (Accessed 21 February 2020); SARS—Practical and administrative responses to an infectious disease in the workplace (2004), https://www.ilo.org/global/topics/safety-and-health-at-work/resources-library/publications/WCMS_108546/lang-en/index.htm, (Accessed 21 February 2020); Dinh, A., Séverin, A., Havette, P., Ebola: What do you need to know? (2015) Archives des Maladies Professionnelles et de l'Environnement, 76, pp. 40-42. , (in French); Descatha, A., Dolveck, F., Salomon, J., A contingency plan for healthcare worker protection in the event of a flu pandemic (2006) J Occup Environ Med, 48, pp. 660-661",,,Elsevier Ltd,24682667,,,32119831,English,Lancet Public Health,Letter,Final,Open Access,Scopus,2-s2.0-85082197985,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Lu K.-L., Chen S., Leung L.-P.",57215846044;57215843103;7202048086;,Initial Experience of an Emergency Department in Shenzhen in Responding to the Emerging Wuhan Coronavirus Pneumonia,2020,Annals of Emergency Medicine,75,4,,556,,,,10.1016/j.annemergmed.2020.02.006,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082090359&doi=10.1016%2fj.annemergmed.2020.02.006&partnerID=40&md5=eb1164640c9dcbe219a660860823071c,"Department of Accident and Emergency, The University of Hong Kong–Shenzhen Hospital, Shenzhen, China; Emergency Medicine Unit, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong","Lu, K.-L., Department of Accident and Emergency, The University of Hong Kong–Shenzhen Hospital, Shenzhen, China; Chen, S., Department of Accident and Emergency, The University of Hong Kong–Shenzhen Hospital, Shenzhen, China; Leung, L.-P., Emergency Medicine Unit, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong",[No abstract available],,China; coronavirus disease 2019; Coronavirus infection; emergency health service; emergency ward; human; Letter; predictive value; priority journal; thorax radiography; virus pneumonia; x-ray computed tomography,"Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395, pp. 507-513; Self, W.H., Courtney, D.M., McNaughton, C.D., High discordance of chest X-ray and CT for detection of pulmonary opacities in ED patients: implications for diagnosing pneumonia (2013) Am J Emerg Med, 31, pp. 401-405",,,Mosby Inc.,1960644,,AEMED,32216893,English,Ann. Emerg. Med.,Letter,Final,Open Access,Scopus,2-s2.0-85082090359,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhang Y., Xu J., Li H., Cao B.",57215782325;57209110414;57214759415;26022302100;,A Novel Coronavirus (COVID-19) Outbreak: A Call for Action,2020,Chest,157,4,,e99,e101,,,10.1016/j.chest.2020.02.014,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082075964&doi=10.1016%2fj.chest.2020.02.014&partnerID=40&md5=7f6d53294b57bf8567c4f58e219b2e9e,"Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China; National Clinical Research Center for Respiratory Diseases, Beijing, China; Department of Respiratory Medicine, Capital Medical University, Beijing, China; Department of Basic Medical Sciences, Tsinghua University School of Medicine, Beijing, China","Zhang, Y., Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China, National Clinical Research Center for Respiratory Diseases, Beijing, China, Department of Respiratory Medicine, Capital Medical University, Beijing, China; Xu, J., Department of Basic Medical Sciences, Tsinghua University School of Medicine, Beijing, China; Li, H., Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China, National Clinical Research Center for Respiratory Diseases, Beijing, China, Department of Respiratory Medicine, Capital Medical University, Beijing, China; Cao, B., Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China, National Clinical Research Center for Respiratory Diseases, Beijing, China, Department of Respiratory Medicine, Capital Medical University, Beijing, China",[No abstract available],,,"Statement on the second meeting of the International Health Regulations (2005) Emergency Committee regarding the outbreak of novel coronavirus (2019-nCoV) https://www.who.int/news-room/detail/30-01-2020-statement-on-the-second-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-outbreak-of-novel-coronavirus-(2019-ncov), (Accessed 1 February 2020); Summary of probable SARS cases with onset of illness from 1 November 2002 to 31 July 2003 https://www.who.int/csr/sars/country/table2004_04_21/en/, (Accessed 1 February 2020); Middle East respiratory syndrome coronavirus (MERS-CoV) http://www.who.int/emergencies/mers-cov/en/, (Accessed 1 February 2020); Epidemic update and risk assessment of 2019-nCoV http://www.chinacdc.cn/yyrdgz/202001/P020200128523354919292.pdf, (Accessed 1 February 2020); Centers for Disease Control and Prevention, (2020), https://www.cdc.gov/ coronavirus/2019-nCoV/summary.html, 2019 Novel coronavirus (2019-nCoV), Wuhan, China. Accessed February 1; Zhou, P., Yang, X.L., Wang, X.G., A pneumonia outbreak associated with a new coronavirus of probable bat origin [published online ahead of print February 3, 2020]. Nature; Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 [published online ahead of print January 24, 2020]. N Engl J Med; Lu, R.J., Zhao, X., Li, J., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding [published online ahead of print January 29, 2020]. Lancet; Ren, L.L., Wang, Y.M., Wu, Z.Q., Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study [published online ahead of print February 11, 2020]. Chin Med J (Engl); Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395 (10223), pp. 497-506; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395 (10223), pp. 507-513; Chan, J.F.W., Yuan, S., Kok, K.H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, 395 (10223), pp. 514-523; Li, Q., Guan, X.H., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus–infected pneumonia [published online ahead of print January 29, 2020]. N Engl J Med; Bauch, C.T., Lloyd-Smith, J.O., Coffee, M.P., Galvani, A.P., Dynamically modeling SARS and other newly emerging respiratory illnesses: past, present, and future (2005) Epidemiology, 16 (6), pp. 791-801; de Wit, E., van Doremalen, N., Falzarano, D., Munster, V.J., SARS and MERS: recent insights into emerging coronaviruses (2016) Nat Rev Microbiol, 14 (8), pp. 523-534; Alshahrani, M.S., Sindi, A., Alshamsi, F., Extracorporeal membrane oxygenation for severe Middle East respiratory syndrome coronavirus (2018) Ann Intensive Care, 8 (1), p. 3; Chu, C.M., Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings (2004) Thorax, 59 (3), pp. 252-256; Arabi, Y.M., Alothman, A., Balkhy, H.H., Treatment of Middle East respiratory syndrome with a combination of lopinavir-ritonavir and interferon-β1b (MIRACLE trial): study protocol for a randomized controlled trial (2018) Trials, 19 (1), p. 81; Mulangu, S., Dodd, L.E., Davey, R.T., A randomized, controlled trial of Ebola virus disease therapeutics (2019) N Engl J Med, 381 (24), pp. 2293-2303; Holshue, M.L., DeBolt, C., Lindquist, S., First case of 2019 novel coronavirus in the United States [published online ahead of print January 31, 2020]. N Engl J Med; Mild/moderate 2019-nCoV Remdesivir RCT. NCT04252664. ClinicalTrials.gov (2020), https://clinicaltrials.gov/ct2/show/NCT04252664?term=remdesivir&draw=2&rank=2, National Institutes of Health Bethesda, MD Updated February 24, 2020; Severe 2019-nCoV Remdesivir RCT. NCT04257656. ClinicalTrials.gov (2020), https://clinicaltrials.gov/ct2/show/NCT04257656?term=remdesivir&draw=2&rank=1, National Institutes of Health Bethesda, MD Updated February 24, 2020; Kirchdoerfer, R.N., Ward, A.B., Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors (2019) Nat Commun, 10 (1), p. 2342; Vincent, J.M., Marion, K., van Neeltje, DA., van Riel, D., de Wit E. Novel coronavirus emerging in China—key questions for impact assessment [published online ahead of print January 24, 2020]. N Engl J Med","Cao, B.No. 2, East Yinghua Rd, Chaoyang District, China; email: caobin_ben@163.com",,Elsevier Inc,123692,,CHETB,32087216,English,Chest,Editorial,Final,,Scopus,2-s2.0-85082075964,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Li R., Qiao S., Zhang G.",57215774060;57215831225;7405271571;,Analysis of angiotensin-converting enzyme 2 (ACE2) from different species sheds some light on cross-species receptor usage of a novel coronavirus 2019-nCoV,2020,Journal of Infection,80,4,,469,496,,1,10.1016/j.jinf.2020.02.013,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082004731&doi=10.1016%2fj.jinf.2020.02.013&partnerID=40&md5=6cb3452c7ff2a439c26287bcda7a1d4e,"Key Laboratory of Animal Immunology of the Ministry of Agriculture, Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou, 450002, China; College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, 45002, China","Li, R., Key Laboratory of Animal Immunology of the Ministry of Agriculture, Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou, 450002, China; Qiao, S., Key Laboratory of Animal Immunology of the Ministry of Agriculture, Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou, 450002, China; Zhang, G., Key Laboratory of Animal Immunology of the Ministry of Agriculture, Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou, 450002, China, College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, 45002, China",[No abstract available],,angiotensin converting enzyme 2; viral protein; 2019 novel coronavirus; agricultural worker; amino acid sequence; bat; binding affinity; bovine; cat; chicken; chimpanzee; China; Chlorocebus; Coronavirinae; Coronavirus infection; dog; horse; human; hydrogen bond; hydrophobicity; Hylobatidae; Letter; livestock; Macaca; Mustela putorius furo; nonhuman; orangutan; pig; protein protein interaction; sheep; static electricity; travel; virus cell interaction,"Wu, F., Zhao, S., Yu, B., Chen, Y.-M., Wang, W., Song, Z.-G., A new coronavirus associated with human respiratory disease in China (2020) Nature, , 32015508 PubMed PMID:; Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med, , 31995857 PubMed PMID:; Li, W., Moore, M.J., Vasilieva, N., Sui, J., Wong, S.K., Berne, M.A., Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus (2003) Nature, 426 (6965), pp. 450-454. , 14647384 PubMed PMID:; Zhou, P., Yang, X.-L., Wang, X.-G., Hu, B., Zhang, L., Zhang, W., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature, , 32015507 PubMed PMID:; Letko, M., Munster, V., (2020), Functional assessment of cell entry and receptor usage for lineage b β-coronaviruses, including 2019-nCoV. bioRxiv. 202001.22.915660; Wan, Y., Shang, J., Graham, R., Baric, R.S., Li, F., Receptor recognition by novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS (2020) J Virol, , 31996437 JVI.00127-20. PubMed PMID:. eng; Hulswit, R.J.G., de Haan, C.A.M., Bosch, B.J., Coronavirus spike protein and tropism changes (2016) Adv Virus Res, 96, pp. 29-57. , 27712627 PubMed PMID:. Epub 2016/09/13. eng; Li, F., Structure, function, and evolution of coronavirus spike proteins (2016) Annu Rev Virol, 3 (1), pp. 237-261. , 27578435 PubMed PMID:. Epub 2016/08/25. eng; Li, F., Li, W., Farzan, M., Harrison, S.C., Structure of sars coronavirus spike receptor-binding domain complexed with receptor (2005) Science, 309 (5742), pp. 1864-1868. , 16166518 PubMed PMID:. eng; Li, F., Structural analysis of major species barriers between humans and palm civets for severe acute respiratory syndrome coronavirus infections (2008) J Virol, 82 (14), pp. 6984-6991. , 18448527 PubMed PMID:. Epub 2008/04/30. eng","Zhang, G.; Key Laboratory of Animal Immunology of the Ministry of Agriculture, Henan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural SciencesChina; email: zhanggaip@126.com",,W.B. Saunders Ltd,1634453,,JINFD,32092392,English,J. Infect.,Letter,Final,Open Access,Scopus,2-s2.0-85082004731,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Khanna R.C., Honavar S.G.",14060213400;7003887441;,All eyes on Coronavirus-What do we need to know as ophthalmologists,2020,Indian Journal of Ophthalmology,68,4,,549,553,,,10.4103/ijo.IJO_516_20,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081970023&doi=10.4103%2fijo.IJO_516_20&partnerID=40&md5=8d7ae71343c565bb4bc262ad1d6b8ca9,"Allen Foster Community Eye Health Research Centre, Gullpalli Pratibha Rao International Centre for Advancement of Rural Eye Care, LV Prasad Eye Institute, Indian Journal of Ophthalmology, Centre for Sight, Banjara Hills, Road No 2, Hyderabad, Telangana, 500 034, India","Khanna, R.C., Allen Foster Community Eye Health Research Centre, Gullpalli Pratibha Rao International Centre for Advancement of Rural Eye Care, LV Prasad Eye Institute, Indian Journal of Ophthalmology, Centre for Sight, Banjara Hills, Road No 2, Hyderabad, Telangana, 500 034, India; Honavar, S.G., Allen Foster Community Eye Health Research Centre, Gullpalli Pratibha Rao International Centre for Advancement of Rural Eye Care, LV Prasad Eye Institute, Indian Journal of Ophthalmology, Centre for Sight, Banjara Hills, Road No 2, Hyderabad, Telangana, 500 034, India",[No abstract available],,,"https://en.wikipedia.org/wiki/Li_Wenliang, Last accessed on 2020 Mar 16; Wang, C., Horby, P.W., Hayden, F.G., Gao, G.F., A novel coronavirus outbreak of global health concern (2020) Lancet, 395, pp. 470-473. , London, England; Xia, J., Tong, J., Liu, M., Shen, Y., Guo, D., Evaluation of coronavirus in tears and conjunctival secretions of patients with SARS'CoV'2 infection (2020) J Med Virol; https://www.who.int/emergencies/diseases/novel'coronavirus'2019, Last accessed on 2020 Mar 16; https://www.mohfw.gov.in/, Last accessed on 2020 Mar 16; Khan, S., Siddique, R., Ali, A., Xue, M., Nabi, G., Novel coronavirus, poor quarantine, and the risk of pandemic (2020) J Hosp Infect; https://www.cdc.gov/coronavirus/2019'ncov/index.html, Last accessed on 2020 Mar 16; Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Early transmission dynamics in Wuhan, China, of novel coronavirus'infected pneumonia N Engl J Med, 2020; Jiang, F., Deng, L., Zhang, L., Cai, Y., Cheung, C.W., Xia, Z., Review of the clinical characteristics of coronavirus disease 2019 (COVID'19) (2020) J Gen Int Med; Jung, S.M., Akhmetzhanov, A.R., Hayashi, K., Linton, N.M., Yang, Y., Yuan, B., Real'time estimation of the risk of death from novel coronavirus (COVID'19) infection: Inference using exported cases (2020) J Clin Med, (9), p. 523; Paules, C.I., Marston, H.D., Fauci, A.S., Coronavirus infections'more than just the common cold (2020) JAMA; Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study (2020) Lancet, 395, pp. 507-513. , London, England; Del Rio, C., Malani, P.N., Novel coronavirus'important information for clinicians (2019) JAMA, 2020; Phan, L.T., Nguyen, T.V., Luong, Q.C., Nguyen, T.V., Nguyen, H.T., Le, H.Q., Importation and human'to'human transmission of a novel coronavirus in Vietnam (2020) N Engl J of Med, 382, pp. 872-874; Chan, J.F., Yuan, S., Kok, K.H., To, K.K., Chu, H., Yang, J., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person'to'person transmission: A study of a family cluster (2020) Lancet, 395, pp. 514-523. , London, England; Ong, S.W.X., Tan, Y.K., Chia, P.Y., Lee, T.H., Ng, O.T., Wong, M.S.Y., Air, surface environmental, and personal protective equipment contamination by severe acute respiratory syndrome coronavirus 2 (SARS'CoV'2) from a symptomatic patient (2020) JAMA; Han, Q., Lin, Q., Ni, Z., You, L., Uncertainties about the transmission routes of 2019 novel coronavirus. Influenza and other respiratory viruses (2020) Influenza Other Respir Viruses; Corman, V.M., Landt, O., Kaiser, M., Molenkamp, R., Meijer, A., Chu, D.K.W., Detection of 2019 novel coronavirus (2019'nCoV) by real'time RT'PCR (2020) Euro Surveill, 25; Lu, C.W., Liu, X.F., Jia, Z.F., 2019'nCoV transmission through the ocular surface must not be ignored Lancet, 395. , London, England) 2020; https://www.aao.org/headline/coronavirus'kills'chinese'whistleblower'ophthalmol, Last accessed on 2020 Mar 16; Chang, X.H., Rebaza, A., Sharma, L., Dela Cruz, C.S., Protecting health'care workers from subclinical coronavirus infection (2020) Lancet Respir Med, 8; https://www.aao.org/headline/alert'important'coronavirus'context, Last accessed on 2020 Mar 16; Cheng, V.C.C., Wong, S.C., Chen, J.H.K., Escalating infection control response to the rapidly evolving epidemiology of the coronavirus disease 2019 (COVID'19) due to SARS'CoV'2 in Hong Kong Infect Control Hosp Epidemiol, 2020, pp. 1-24; Lai, T.H.T., Tang, E.W.H., Chau, S.K.Y., Fung, K.S.C., Li, K.K.W., Stepping up infection control measures in ophthalmology during the novel coronavirus outbreak: An experience from Hong Kong (2020) Graefes Arch Clin Exp Ophthalmol; Tran, K., Cimon, K., Severn, M., Pessoa'Silva, C.L., Conly, J., Aerosol generating procedures and risk of transmission of acute respiratory infections to healthcare workers: A systematic review (2012) PLoS One, 7; https://www.who.int/gpsc/5may/tools/9789241597906/en/, Last accessed on 2020 Mar 16; https://www.weforum.org/agenda/2020/03/coronavirus'keep'things'in'perspective'reasons'not'to'panic/, Last accessed on 2020 Mar 16","Honavar, S.G.; Allen Foster Community Eye Health Research Centre, Gullpalli Pratibha Rao International Centre for Advancement of Rural Eye Care, LV Prasad Eye Institute, Indian Journal of Ophthalmology, Centre for Sight, Banjara Hills, Road No 2, India; email: santosh.honavar@gmail.com",,Wolters Kluwer Medknow Publications,3014738,,IJOMB,32174565,English,Indian J. Ophthalmol.,Editorial,Final,Open Access,Scopus,2-s2.0-85081970023,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Peña-Otero D., Díaz-Pérez D., de-la-Rosa-Carrillo D., Bello-Dronda S.",57193739381;57193845677;56150748800;6602709163;,Are We Ready for the New Coronavirus? [¿Preparados para el nuevo coronavirus?],2020,Archivos de Bronconeumologia,56,4,,195,196,,,10.1016/j.arbres.2020.02.009,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081909310&doi=10.1016%2fj.arbres.2020.02.009&partnerID=40&md5=999228092deb0b6e23078f1e36f795ce,"Hospital Sierrallana, Servicio Cántabro de Salud, Torrelavega, Cantabria, Spain; Hospital Universitario Nuestra Señora de Candelaria, Servicio Canario de Salud, Santa Cruz de Tenerife, Tenerife, Spain; Hospital de la Santa Creu i Sant Pau, Barcelona, Spain; Servicio de Neumología, Hospital Universitario Miguel Servet, Zaragoza, Spain; Área de Enfermería Respiratoria de la SEPAR, Spain; Área de Tuberculosis e Infecciones Respiratorias (TIR) de la SEPAR, Spain","Peña-Otero, D., Hospital Sierrallana, Servicio Cántabro de Salud, Torrelavega, Cantabria, Spain, Área de Enfermería Respiratoria de la SEPAR, Spain; Díaz-Pérez, D., Hospital Universitario Nuestra Señora de Candelaria, Servicio Canario de Salud, Santa Cruz de Tenerife, Tenerife, Spain, Área de Enfermería Respiratoria de la SEPAR, Spain; de-la-Rosa-Carrillo, D., Hospital de la Santa Creu i Sant Pau, Barcelona, Spain, Área de Tuberculosis e Infecciones Respiratorias (TIR) de la SEPAR, Spain; Bello-Dronda, S., Servicio de Neumología, Hospital Universitario Miguel Servet, Zaragoza, Spain",[No abstract available],,2019 novel coronavirus; China; Coronavirinae; Editorial; nonhuman,"Phelan, A.L., Katz, R., Gostin, L.O., The Novel Coronavirus Originating in Wuhan, China: Challenges for Global Health Governance (2020) JAMA; Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China (2020) JAMA; Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study (2020) Lancet, 395, pp. 507-513. , S0140-6736(20)30211-7; Liu, P., Chen, W., Chen, J.P., Viral Metagenomics Revealed Sendai Virus and Coronavirus Infection of Malayan Pangolins (Manis javanica) (2019) Viruses, 11, p. pii E979. , 3390/v11110979; Chan, J.F., Yuan, S., Kok, K.H., To, K.K., Chu, H., Yang, J., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: A study of a family cluster (2020) Lancet, 395, pp. 514-523. , S0140-6736(20)30154-9; https://www.mscbs.gob.es/profesionales/saludPublica/ccayes/alertasActual/nCov-China/documentos/Manejo_urgencias_pacientes_con_COVID-19.pdf, Ministerio de Sanidad. Gobierno de España. Manejo en urgencias y primera atención de pacientes con sospecha de COVID-19. Informe Técnico. DOI: 10.13140/RG.2.2.12122.90568 [actualizado 23 Feb 2020; consultado 23 Feb 2020]. Disponible en:; Sheahan, T.P., Sims, A.C., Leist, S.R., Schäfer, A., Won, J., Brown, A.J., Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV (2020) Nat Commun, 11, p. 222; Russell, C.D., Millar, J.E., Baillie, J.K., Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury (2020) Lancet, 395, pp. 473-475. , S0140-6736(20)30317-2; Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med; Centers for Disease Control and Prevention, https://www.cdc.gov/coronavirus/2019-ncov/about/transmission.html, How 2019-nCoV spreads [actualizado 11 Feb 2020; consultado 14 Feb 2020]. Disponible en:; Kupferschmidt, K., Study claiming new coronavirus can be transmitted by people without symptoms was flawed (2020) Science (published online Feb 3); World Health Organization, https://www.who.int/docs/default-source/documents/advice-on-the-use-of-masks-2019-ncov.pdf, Advice on the use of masks in the community, during home care and in health care settings in the context of the novel coronavirus (2019-nCoV) outbreak. Interim guidance [consultado 12 Feb 2020]. Disponible en: Updated 29/I/2020; Centers for Disease Control and Prevention, https://www.cdc.gov/coronavirus/2019-ncov/hcp/guidance-for-ems.html, Interim guidance for emergency medical services (EMS) systems and 911 public safety answering points (PSAPs) for 2019-nCoV in the United States [consultado 12 Feb 2020]. Disponible en: Updated 06/II/2020; https://www.mscbs.gob.es/profesionales/saludPublica/ccayes/alertasActual/nCov-China/documentos/ITCoronavirus.pdf, Ministerio de Sanidad. Gobierno de España. Informe Técnico. Nuevo coronavirus 2019-nCoV. Instituto de Salud Carlos III. Dirección General de Salud Pública, Calidad e Innovación. Centro de Coordinación de Alertas y Emergencias Sanitarias [consultado 12 Feb 2020]. Disponible en: Updated 10/II/2020; World Health Organization, https://apps.who.int/iris/handle/10665/330674, Infection prevention and control during health care when novel coronavirus (nCoV) infection is suspected: Interim guidance [consultado 11 Feb 2020]. Disponible en: Licencia: CC BY-NC-SA 3.0 IGO. Updated 25/I/2020; https://www.ecdc.europa.eu/en/publications-data/guidelines-use-non-pharmaceutical-measures-delay-and-mitigate-impact-2019-ncov, European Centre for Disease Prevention and Control. Guidelines for the use of non-pharmaceutical measures to delay and mitigate the impact of 2019-nCoV [consultado 12 Feb 2020]. Disponible en: Updated 10/II/2020; Chen, J., Pathogenicity and transmissibility of 2019-nCoV-A quick overview and comparison with other emerging viruses (2020) Microbes Infect, , S1286-4579(20)30026-5","Bello-Dronda, S.; Servicio de Neumología, Hospital Universitario Miguel ServetSpain; email: sbello@salud.aragon.es",,Elsevier Doyma,3002896,,ARBRD,,English; Spanish,Arch. Bronconeumol.,Editorial,Final,Open Access,Scopus,2-s2.0-85081909310,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Stein R.A.,56683891600;,"The 2019 coronavirus: Learning curves, lessons, and the weakest link",2020,International Journal of Clinical Practice,74,4, e13488,,,,1,10.1111/ijcp.13488,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081733455&doi=10.1111%2fijcp.13488&partnerID=40&md5=2d14f4a18db58b692446b8bc19cb0a60,"Chemical and Biomolecular Engineering, New York University Tandon School of Engineering, Brooklyn, NY, United States; Department of Natural Sciences, LaGuardia Community College, Long Island City, NY, United States","Stein, R.A., Chemical and Biomolecular Engineering, New York University Tandon School of Engineering, Brooklyn, NY, United States, Department of Natural Sciences, LaGuardia Community College, Long Island City, NY, United States",[No abstract available],,antipyretic agent; virus spike protein; amino acid analysis; amino acid substitution; Coronavirinae; coronavirus disease 2019; Coronavirus infection; Editorial; fever; genetic similarity; health education; human; incubation time; learning curve; life expectancy; mortality; nonhuman; pandemic; patient transport; pneumonia; priority journal; quarantine; SARS coronavirus; sequence homology; severe acute respiratory syndrome; severe acute respiratory syndrome coronavirus 2; Spanish influenza; virus cell interaction; virus genome; virus transmission; aged; editorial; global health; infant; Middle East respiratory syndrome coronavirus,"Graham, R.L., Donaldson, E.F., Baric, R.S., A decade after SARS: strategies for controlling emerging coronaviruses (2013) Nat Rev Microbiol, 11, pp. 836-848; 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Coronavirus updates: The illness now has a name: COVID-19 (2020) The New York Times, , https://wwwnytimescom/2020/02/11/world/asia/coronavirus-chinahtml, Accessed February 11, 2020; Dahlberg, B., Renken, E., New coronavirus disease officially named COVID-19 by the World Health Organization (2020) National Public Radio, , https://wwwnprorg/sections/goatsandsoda/2020/02/11/802352351/new-coronavirus-gets-an-official-name-from-the-world-health-organization, Accessed February 11, 2020; Coronavirus latest: WHO officially names disease COVID-19 (2020) Nature, , https://www.nature.com/articles/d41586-020-00154-w, Accessed February 12, 2020; (2020) Emergencies preparedness, response. 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A first step in understanding SARS pathogenesis (2004) J Pathol, 203, pp. 631-637; Wan, Y., Shang, J., Graham, R., Baric, R.S., Li, F., Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS (2020) J Virol, , https://doi.org/10.1128/JVI.00127-20, [Epub ahead of print]; Jiang, S., He, Y., Liu, S., SARS vaccine development (2005) Emerg Infect Dis, 11, pp. 1016-1020; Li, W., Wong, S.-K., Li, F., Animal origins of the severe acute respiratory syndrome coronavirus: insight from ACE2-S-protein interactions (2006) J Virol, 80, pp. 4211-4219; Liang, G., Chen, Q., Xu, J., Laboratory diagnosis of four recent sporadic cases of community-acquired SARS, Guangdong Province, China (2004) Emerg Infect Dis, 10, pp. 1774-1781; Drew, A., China is about to find out whether its mass quarantine worked (2020) Bloomberg, , https://www.bloomberg.com/news/articles/2020-02-04/will-china-s-coronavirus-quarantine-halt-the-virus, Accessed on February 8, 2020; Baker, S., China's unprecedented quarantine of 11 million people in Wuhan is 2 weeks old. Here's what it's like in the isolated city (2020) Business Insider, , https://www.businessinsider.com/wuhan-coronavirus-what-life-like-inside-quarantined-city-china-2020-2, Accessed February 8, 2020; Ryu, S., Gao, H., Wong, J.Y., Nonpharmaceutical measures for pandemic influenza in nonhealthcare settings-international travel-related measures (2020) Emerg Infect Dis, 26; Summers, J.A., Wilson, N., Baker, M.G., Gottfredsson, M., The influenza pandemic of 1918–1919 in two remote island nations: Iceland and New Zealand (2013) N Z Med J, 126, pp. 74-80; Chong, K.C., Ying Zee, B.C., Modeling the impact of air, sea, and land travel restrictions supplemented by other interventions on the emergence of a new influenza pandemic virus (2012) BMC Infect Dis, 12, p. 309; Nishiura, H., Wilson, N., Baker, M.G., Quarantine for pandemic influenza control at the borders of small island nations (2009) BMC Infect Dis, 9, p. 27; Tognotti, E., Lessons from the history of quarantine, from plague to influenza A (2013) Emerg Infect Dis, 19, pp. 254-259; Martinez, D.L., Das, T.K., Design of non-pharmaceutical intervention strategies for pandemic influenza outbreaks (2014) BMC Public Health, 14, p. 1328; Matthews Pillemer, F., Blendon, R.J., Zaslavsky, A.M., Lee, B.Y., Predicting support for non-pharmaceutical interventions during infectious outbreaks: a four region analysis (2015) Disasters, 39, pp. 125-145; Ahmed, F., Zviedrite, N., Uzicanin, A., Effectiveness of workplace social distancing measures in reducing influenza transmission: a systematic review (2018) BMC Public Health, 18, p. 518; Smith, R., Social measures may control pandemic flu better than drugs and vaccines (2007) BMJ, 334, p. 1341; Hatchett, R.J., Mecher, C.E., Lipsitch, M., Public health interventions and epidemic intensity during the 1918 influenza pandemic (2007) Proc Natl Acad Sci USA, 104, pp. 7582-7587; Baker, S., (2020) Fears are rising over the spread of China's deadly Wuhan virus, which has now reached the US. 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(2004) Med J Aust, 180, pp. 220-223; St. John, R.K., King, A., de Jong, D., Bodie-Collins, M., Squires, S.G., Tam, T.W.S., Border screening for SARS (2005) Emerg Infect Dis, 11, pp. 6-10; Mouchtouri, V.A., Christoforidou, E.P., An der Heiden, M., Exit and entry screening practices for infectious diseases among travelers at points of entry: looking for evidence on public health impact (2019) Int J Environ Res Public Health, 16, p. 4638; Bell, D.M., Public health interventions and SARS spread, 2003 (2004) Emerg Infect Dis, 10, pp. 1900-1906; Use of quarantine to prevent transmission of severe acute respiratory syndrome–Taiwan, 2003 (2003) MMWR Morb Mortal Wkly Rep, 52, pp. 680-683; Petrosillo, N., Puro, V., Ippolito, G., Border screening for SARS (2004) Med J Aust, 180, p. 597; Gostic, K.M., Kucharski, A.J., Lloyd-Smith, J.O., Effectiveness of traveller screening for emerging pathogens is shaped by epidemiology and natural history of infection (2015) Elife, 4. , https://doi.org/10.7554/eLife.05564; Morse, S.S., Mazet, J.A.K., Woolhouse, M., Prediction and prevention of the next pandemic zoonosis (2012) Lancet, 380, pp. 1956-1965; O'Dowd, A., Infectious diseases are spreading more rapidly than ever before, WHO warns (2007) BMJ, 335, p. 418; Howard, C.R., Fletcher, N.F., Emerging virus diseases: can we ever expect the unexpected? (2012) Emerg Microbes Infect, 1; Sutherst, R.W., Global change and human vulnerability to vector-borne diseases (2004) Clin Microbiol Rev, 17, pp. 136-173; Meslé, M.M.I., Hall, I.M., Christley, R.M., Leach, S., Read, J.M., The use and reporting of airline passenger data for infectious disease modelling: a systematic review (2019) Euro Surveill, 24. , https://doi.org/10.2807/1560-7917.ES.2019.24.31.1800216; Mangili, A., Vindenes, T., Gendreau, M., Infectious risks of air travel (2015) Microbiol Spectr, 3. , https://doi.org/10.1128/microbiolspec.IOL5-0009-2015; Osterholm, M.T., Preparing for the next pandemic (2005) N Engl J Med, 352, pp. 1839-1842; Heymann, D.L., Rodier, G., Global surveillance, national surveillance, and SARS (2004) Emerg Infect Dis, 10, pp. 173-175; Gallagher, J., Coronavirus super-spreaders: Why are they important? (2020) BBC News, , https://wwwbbccom/news/health-51447143, Accessed February 10, 2020","Stein, R.A.; Chemical and Biomolecular Engineering, New York University Tandon School of EngineeringUnited States; email: richardastein@gmail.com",,Blackwell Publishing Ltd,13685031,,IJCPF,32052918,English,Int. J. Clin. Pract.,Editorial,Final,Open Access,Scopus,2-s2.0-85081733455,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wang J., Qi H., Bao L., Li F., Shi Y., National Clinical Research Center for Child Health and Disorders and Pediatric Committee of Medical Association of Chinese People's Liberation Army",57215696912;57215697542;57215694369;57215697596;57215682275;,A contingency plan for the management of the 2019 novel coronavirus outbreak in neonatal intensive care units,2020,The Lancet Child and Adolescent Health,4,4,,258,259,,3,10.1016/S2352-4642(20)30040-7,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081693207&doi=10.1016%2fS2352-4642%2820%2930040-7&partnerID=40&md5=cd8b30d3426f74b579a03cf0e68628db,"Department of Neonatology, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China; Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China","Wang, J., Department of Neonatology, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China; Qi, H., Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Bao, L., Department of Neonatology, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China; Li, F., Department of Neonatology, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China; Shi, Y., Department of Neonatology, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China; National Clinical Research Center for Child Health and Disorders and Pediatric Committee of Medical Association of Chinese People's Liberation Army",[No abstract available],,adult respiratory distress syndrome; antibiotic therapy; blood analysis; China; computer assisted tomography; contact examination; Coronavirus disease 2019; Coronavirus infection; diagnostic test; disease severity; disinfection; epidemic; feeding difficulty; fever; flu like syndrome; hospital discharge; hospital waste; human; hypoactivity; infection prevention; laboratory test; mental stress; multiple organ failure; neonatal intensive care unit; newborn; Note; parental stress; patient isolation; patient referral; pneumonia; practice guideline; prescription; respiratory failure; risk assessment; screening test; tachypnea; thorax radiography; travel related disease; treatment planning; universal precaution; virus detection; waste management,"Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, , published online Jan 24; Update: cluster of pneumonia cases caused by a novel coronavirus, Wuhan, China (2019), https://www.ecde.europa.eu/en/news-events/update-cluster-pneumonia-cases-associated-novel-coronavirus-wuhan-china-2019, (Accessed 14 January 2020); Li, A.M., Ng, P.C., Severe acute respiratory syndrome (SARS) in neonates and children (2005) Arch Dis Child Fetal Neonatal Ed, 90, pp. F461-F465; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, , published online Jan 24; Laboratory testing for 2019 novel coronavirus (2019-nCoV) in suspected human cases (2019), https://www.who.int/docs/default-source/coronaviruse/20200114-interim-laboratory-guidance-version.pdf?sfvrsn=6967c39b_4&download=true, World Health Organization Geneva (Accessed 17 January 2020); Gagneur, A., Vallet, S., Talbot, P.J., Outbreaks of human coronavirus in a pediatric and neonatal intensive care unit (2008) Eur J Pediatr, 167, pp. 1427-1434; Totura, A.L., Bavari, S., Broad-spectrum coronavirus antiviral drug discovery (2019) Expert Opin Drug Discov, 14, pp. 397-412",,,Elsevier B.V.,23524642,,,32043976,English,Lancet Child Adolesc. Health,Note,Final,Open Access,Scopus,2-s2.0-85081693207,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Shah S.G.S., Farrow A.",14421815800;7004088464;,A commentary on “World Health Organization declares global emergency: A review of the 2019 novel Coronavirus (COVID-19)”,2020,International Journal of Surgery,76,,,128,129,,,10.1016/j.ijsu.2020.03.001,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081680314&doi=10.1016%2fj.ijsu.2020.03.001&partnerID=40&md5=096cb25e2aaa6298bfb544cd9d3c6fb7,"NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Headington Way, Headington, Oxford, England OX3 9DU, United Kingdom; College of Health and Life Sciences, Department of Clinical Sciences, Brunel University London, Uxbridge, UB8 3PH, United Kingdom","Shah, S.G.S., NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Headington Way, Headington, Oxford, England OX3 9DU, United Kingdom; Farrow, A., College of Health and Life Sciences, Department of Clinical Sciences, Brunel University London, Uxbridge, UB8 3PH, United Kingdom",[No abstract available],Coronavirus; Covid-19; Epidemic; Epidemiology; Health emergency; Infectious disease; Outbreak; Pandemic; Preventative measures; Public fear; Public health; Quarantine; Social and economic implications,2019 novel coronavirus; Coronavirinae; Coronavirus infection; emergency care; global health; government; human; Letter; pandemic; prevalence; priority journal; prognosis; public health; quarantine; World Health Organization,"Sohrabi, C., Alsafi, Z., O'Neill, N., Khan, M., Kerwan, A., Al-Jabir, A., Iosifidis, C., Agha, R., World Health Organization declares Global Emergency: A review of the 2019 novel coronavirus (COVID-19) (2020) Int. J. Surg., 76, pp. 71-76; WHO Director-General's opening remarks at the media briefing on COVID-19–11 March 2020 (2020), (Accessed 11 March 2020); Novel Coronavirus (COVID-19) Situation (2020), (Accessed 11 March 2020); Coronavirus COVID-19 Global Cases (2020), (Accessed 11 March 2020); Statement on the second meeting of the International Health Regulations (2005) Emergency Committee regarding the outbreak of novel coronavirus (2019-nCoV) (2020), (Accessed 11 March 2020); Zhao, S., Lin, Q., Ran, J., Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: A data-driven analysis in the early phase of the outbreak (2020) Int. J. Infect. Dis., 92, pp. 214-217; Worldometer, COVID-19 CORONAVIRUS OUTBREAK (2020), [[Last updated: March 11, 2020, 23:20 GMT]. (Accessed 11 March 2020); Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus–infected pneumonia (2020) N. Engl. J. Med.; Shepherd, M., The Science Of Why Coronavirus Exposes Racism And Xenophobia (2020), Forbes; Isidore, C., The travel industry is suffering its worst shock since 9/11 because of coronavirus (2020), CNN Business (Accessed 2 March 2020); Gryta, T., Adams, R., Coronavirus Is Different. It's Rapidly Hitting Supply and Demand (2020) The Wall Street Journal, , (Accessed 2 March 2020); Tappe, A., Dow falls 1,191 points -- the most in history (2020), CNN Business (Accessed 2 March 2020); Horobin, W., Virus Pushes Global Economy Toward First Contraction Since 2009 (2020), Bloomberg (Accessed 2 March 2020); The Health Protection (Coronavirus) Regulations 2020. London, UK (2020), Bloomberg (Accessed 10 March 2020); Coronavirus: France bans large indoors gatherings in bid to curb virus, London, UK (2020), (Accessed 2 March 2020); Williams, T.-A., Saudi Arabia finally BANS religious pilgrims from visiting Mecca or Medina to prevent the spread of coronavirus in the Kingdom (2020), Daily Mail Online. (Accessed 10 March 2020); Batmanghelidj, E., Kebriaeezadeh, A., As Coronavirus Spreads, Iranian Doctors Fear the Worst (2020), Foreign Policy (Accessed 7 March 2020)","Shah, S.G.S.; NIHR Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Headington Way, Headington, United Kingdom; email: Sarwar.Shah@ouh.nhs.uk",,Elsevier Ltd,17439191,,,32169574,English,Int. J. Surg.,Letter,Final,Open Access,Scopus,2-s2.0-85081680314,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Elston D.M.,7103398989;,The coronavirus (COVID-19) epidemic and patient safety,2020,Journal of the American Academy of Dermatology,82,4,,819,820,,,10.1016/j.jaad.2020.02.031,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081237619&doi=10.1016%2fj.jaad.2020.02.031&partnerID=40&md5=cbad33a1f2e43090564808cb8c0c2ae6,"Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, SC, United States","Elston, D.M., Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, SC, United States",[No abstract available],,2019 novel coronavirus; Coronavirinae; Coronavirus infection; Editorial; epidemic; human; infection control; isolation; necrotizing fasciitis; nonhuman; patient safety; priority journal; Streptococcus infection; virus transmission; Betacoronavirus; Coronavirinae; dermatology; outpatient; patient safety; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; Coronavirus; Dermatology; Humans; Outpatients; Patient Safety,"Chen, Y., Pradhan, S., Xue, S., What are we doing in the dermatology outpatient department amidst the raging of the 2019 novel coronavirus? (2020) J Am Acad Dermatol, 82, p. 1034; Herwaldt, L., Smith, S., Carter, C., Infection control in the outpatient setting (1998) Infect Control Hosp Epidemiol, 19 (1), pp. 41-74; Preblud, S.R., Nosocomial varicella. Worth preventing, but how? (1988) Am J Public Health, 78, pp. 13-15; Alanazi, K.H., Killerby, M.E., Biggs, H.M., Scope and extent of healthcare-associated Middle East respiratory syndrome coronavirus transmission during two contemporaneous outbreaks in Riyadh, Saudi Arabia, 2017 (2019) Infect Control Hosp Epidemiol, 40 (1), pp. 79-88; Beaudoin, A.L., Torso, L., Richards, K., Invasive group A Streptococcus infections associated with liposuction surgery at outpatient facilities not subject to state or federal regulation (2014) JAMA Intern Med, 174 (7), pp. 1136-1142; Elston, D.M., Stratman, E., Johnson-Jahangir, H., Watson, A., Swiggum, S., Hanke, C.W., Patient safety: part II. Opportunities for improvement in patient safety (2009) J Am Acad Dermatol, 61 (2), pp. 193-205; Elston, D.M., Taylor, J.S., Coldiron, B., Patient safety: part I. Patient safety and the dermatologist (2009) J Am Acad Dermatol, 61 (2), pp. 179-190; Brewer, J.D., Elston, D.M., Vidimos, A.T., Rizza, S.A., Miller, S.J., Managing sharps injuries and other occupational exposures to HIV, HBV, and HCV in the dermatology office (2017) J Am Acad Dermatol, 77 (5), pp. 946-951.e6","Elston, D.M.; Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, MSC 578, 135 Rutledge Ave, 11th Floor, United States; email: elstond@musc.edu",,Mosby Inc.,1909622,,JAADD,32074487,English,J. Am. Acad. Dermatol.,Editorial,Final,,Scopus,2-s2.0-85081237619,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Chen Y., Pradhan S., Xue S.",57215580578;57190578293;55422841600;,What are we doing in the dermatology outpatient department amidst the raging of the 2019 novel coronavirus?,2020,Journal of the American Academy of Dermatology,82,4,,1034,,,1,10.1016/j.jaad.2020.02.030,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081207857&doi=10.1016%2fj.jaad.2020.02.030&partnerID=40&md5=94cd273e182a4d8588b11519742c1d16,"Department of Dermatology, West China Hospital of Sichuan University, China","Chen, Y., Department of Dermatology, West China Hospital of Sichuan University, China; Pradhan, S., Department of Dermatology, West China Hospital of Sichuan University, China; Xue, S., Department of Dermatology, West China Hospital of Sichuan University, China",[No abstract available],,,"Lu, R., Zhao, X., Li, J., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet; Holshue, M.L., DeBolt, C., Lindquist, S., First case of 2019 novel coronavirus in the United States (2020) N Engl J Med","Xue, S.37# Guoxuexiang, China; email: xuesiliang@163.com",,Mosby Inc.,1909622,,JAADD,32081700,English,J. Am. Acad. Dermatol.,Editorial,Final,Open Access,Scopus,2-s2.0-85081207857,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhang S., Diao M., Yu W., Pei L., Lin Z., Chen D.",57215062681;55630446600;57215498214;57215502612;8866419800;55724974400;,Estimation of the reproductive number of novel coronavirus (COVID-19) and the probable outbreak size on the Diamond Princess cruise ship: A data-driven analysis,2020,International Journal of Infectious Diseases,93,,,201,204,,4,10.1016/j.ijid.2020.02.033,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081013965&doi=10.1016%2fj.ijid.2020.02.033&partnerID=40&md5=7bfbde4e0a5ac74e0555532ccdc19101,"Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China; Department of Critical Care Medicine, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, China; Graduate School, Naval Medical University (Second Military Medical University), Shanghai, 200433, China; Department of Emergency and Critical Care Medicine, Changzheng Hospital, Naval Medical University (Second Military Medical University), Shanghai, 200433, China","Zhang, S., Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China; Diao, M., Department of Critical Care Medicine, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, China; Yu, W., Graduate School, Naval Medical University (Second Military Medical University), Shanghai, 200433, China; Pei, L., Graduate School, Naval Medical University (Second Military Medical University), Shanghai, 200433, China; Lin, Z., Department of Emergency and Critical Care Medicine, Changzheng Hospital, Naval Medical University (Second Military Medical University), Shanghai, 200433, China; Chen, D., Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China","Backgrounds: Up to February 16, 2020, 355 cases have been confirmed as having COVID-19 infection on the Diamond Princess cruise ship. It is of crucial importance to estimate the reproductive number (R0) of the novel virus in the early stage of outbreak and make a prediction of daily new cases on the ship. Method: We fitted the reported serial interval (mean and standard deviation) with a gamma distribution and applied “earlyR” package in R to estimate the R0 in the early stage of COVID-19 outbreak. We applied “projections” package in R to simulate the plausible cumulative epidemic trajectories and future daily incidence by fitting the data of existing daily incidence, a serial interval distribution, and the estimated R0 into a model based on the assumption that daily incidence obeys approximately Poisson distribution determined by daily infectiousness. Results: The Maximum-Likelihood (ML) value of R0 was 2.28 for COVID-19 outbreak at the early stage on the ship. The median with 95% confidence interval (CI) of R0 values was 2.28 (2.06–2.52) estimated by the bootstrap resampling method. The probable number of new cases for the next ten days would gradually increase, and the estimated cumulative cases would reach 1514 (1384–1656) at the tenth day in the future. However, if R0 value was reduced by 25% and 50%, the estimated total number of cumulative cases would be reduced to 1081 (981–1177) and 758 (697–817), respectively. Conclusion: The median with 95% CI of R0 of COVID-19 was about 2.28 (2.06–2.52) during the early stage experienced on the Diamond Princess cruise ship. The future daily incidence and probable outbreak size is largely dependent on the change of R0. Unless strict infection management and control are taken, our findings indicate the potential of COVID-19 to cause greater outbreak on the ship. © 2020 The Author(s)",Coronavirus; Epidemiology; Mathematical model; Reproductive number,2019 novel Coronavirus; Article; Coronavirinae; Coronavirus infection; human; incidence; major clinical study; ship,"Delamater, P.L., Street, E.J., Leslie, T.F., Yang, Y.T., Jacobsen, K.H., Complexity of the basic reproduction number (R0) (2019) Emerg Infect Dis, 25 (1), pp. 1-4; Huang, C.L., Wang, Y.M., Li, X.S., Ren, L.L., Zhao, J.P., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, , https://doi.org/10.1016/S0140-6736(20)30183-5, Available from: . [Accessed 24 January 2020]; Jombart, T., Cori, A., Nouvellet, P., earlyR: Estimation of transmissibility in the early stages of a disease outbreak (2017), https://CRAN.R-project.org/package=earlyR, Available from: . [Accessed 6 December 2017]; Jombart, T., Nouvellet, P., Bhatia, S., Kamvar, Z.N., projections: Project future case incidence (2018), https://CRAN.R-project.org/package=projections, Available from: . [Accessed 27 August 2018]; Li, Q., Guan, X.H., Wu, P., Wang, X.Y., Zhou, L., Tong, Y.Q., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med, , https://www.nejm.org/doi/10.1056/NEJMoa2001316, Available from: . [Accessed 29 January 2020]; Ministry of Health, Labour and Welfare of Japan, Identification of novel coronavirus infection on cruise ship in quarantine at Yokohama Port (report 8) (2020), https://www.mhlw.go.jp/stf/newpage_09425.html, Available from: . [Accessed 16 February 2020]; Nouvellet, P., Cori, A., Garske, T., Blake, I.M., Dorigatti, I., Hinsley, W., A simple approach to measure transmissibility and forecast incidence (2018) Epidemics, 22, pp. 29-35; National Health Commission of the People's Republic of China, The latest situation of new coronavirus pneumonia (2020), http://www.nhc.gov.cn/xcs/yqtb/202002/553ff43ca29d4fe88f3837d49d6b6ef1.shtml, Available from: . [Accessed 16 February 2020]; Anon, Virus cases in Hong Kong apartments recall SARS memories (2020), https://apnews.com/2b93091de34ceb1b5ac9443be8abee4c, APNEWS Available from: . [Accessed 11 February 2020]; World Health Organization, Coronavirus disease 2019 (COVID-19) situation report-19 (2020), https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200213-sitrep-24-covid-19.pdf?sfvrsn=9a7406a4_4, Available from: . [Accessed 16 February 2020]; Wu, J.T., Leung, K., Leung, G.M., Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study (2020) Lancet, , https://doi.org/10.1016/S0140-6736(20)30260-9, Available from: . [Accessed 31 January 2020]; Yan, P., Distribution theory, stochastic processes and infectious disease modelling (2008) Mathematical epidemiology, pp. 229-293. , Fred Brauer Pauline van den Driessche Wu Jianhong; Zhao, S., Lin, Q.Y., Ran, J.J., Musa, S.S., Yang, G.P., Wang, W.M., Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: a data-driven analysis in the early phase of the outbreak (2020) Int J Infect Dis, , https://doi.org/10.1016/j.ijid.2020.01.050, Available from: . [Accessed 30 January 2020]","Lin, Z.; Department of Emergency and Critical Care Medicine, Changzheng Hospital, Naval Medical University (Second Military Medical University)China; email: linzhaofen@hotmail.com",,Elsevier B.V.,12019712,,IJIDF,32097725,English,Int. J. Infect. Dis.,Article,Final,Open Access,Scopus,2-s2.0-85081013965,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Carvalho P.M.D.M., Moreira M.M., de Oliveira M.N.A., Landim J.M.M., Neto M.L.R.",57215502475;55748181800;57215498331;57203636491;54882487200;,The psychiatric impact of the novel coronavirus outbreak,2020,Psychiatry Research,286,,112902,,,,,10.1016/j.psychres.2020.112902,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080990295&doi=10.1016%2fj.psychres.2020.112902&partnerID=40&md5=676cf0bfde1aefe28883f69c452500a8,"Postgraduate Program in Health Sciences, ABC School of Medicine - FMABC, Santo André, São Paulo, Brazil; School of Medicine, Federal University of Cariri – UFCA, Barbalha, Ceará, Brazil; School of Medicine of Juazeiro do Norte – FMJ/Estácio, Juazeiro do Norte, Ceará, Brazil","Carvalho, P.M.D.M., Postgraduate Program in Health Sciences, ABC School of Medicine - FMABC, Santo André, São Paulo, Brazil; Moreira, M.M., Postgraduate Program in Health Sciences, ABC School of Medicine - FMABC, Santo André, São Paulo, Brazil, School of Medicine, Federal University of Cariri – UFCA, Barbalha, Ceará, Brazil, School of Medicine of Juazeiro do Norte – FMJ/Estácio, Juazeiro do Norte, Ceará, Brazil; de Oliveira, M.N.A., School of Medicine of Juazeiro do Norte – FMJ/Estácio, Juazeiro do Norte, Ceará, Brazil; Landim, J.M.M., Postgraduate Program in Health Sciences, ABC School of Medicine - FMABC, Santo André, São Paulo, Brazil; Neto, M.L.R., School of Medicine, Federal University of Cariri – UFCA, Barbalha, Ceará, Brazil, School of Medicine of Juazeiro do Norte – FMJ/Estácio, Juazeiro do Norte, Ceará, Brazil",[No abstract available],,anxiety; comorbidity; coping behavior; coronavirus disease 2019; Coronavirus infection; depression; epidemic; fear; health education; human; insomnia; interpersonal communication; Letter; mental health care; mobile application; panic; patient counseling; priority journal; psychiatry; social stigma; social support,"Xiang, Y.T., Yang, Y., Li, W., Zhang, L., Zhang, Q., Cheung, T., Ng, C.H., Timely mental health care for the 2019 novel coronavirus outbreak is urgently needed (2020) Lancet Psychiatry.; Wu, P., Fang, Y., Guan, Z., Fan, B., Kong, J., Yao, Z., Liu, X., Hoven, C.W., The psychological impact of the SARS epidemic on hospital employees in China: exposure, risk perception, and altruistic acceptance of risk (2009) Can J. Psychiatry, 54, pp. 302-311; Maunder, R., Hunter, J., Vincent, L., Bennett, J., Peladeau, N., Leszcz, M., Sadavoy, J., Mazzulli, T., The immediate psychological and occupational impact of the 2003 SARS outbreak in a teaching hospital (2003) CMAJ, 168, pp. 1245-1251; Folkman, S., Greer, S., Promoting psychological well-being in the face of serious illness: when theory, research and practice inform each other (2000) Psychooncology, 9, pp. 11-19; Wang, C., Horby, P.W., Hayden, F.G., Gao, G.F., A novel coronavirus outbreak of global health concern (2020) Lancet, 395, pp. 470-473; Liu, T.B., Chen, X.Y., Miao, G.D., Recommendations on diagnostic criteria and prevention of SARS-related mental disorders (2003) J. Clin. Psychol. Med., 13, pp. 188-191; Perrett, K., Al-Wali, W., Read, C., Redgrave, P., Trend, U., Outbreak of meningococcal disease in Rotherham illustrates the value of coordination, communication, and collaboration in management (2003) Commun. Dis. Public Health, 3, pp. 168-171; Horowitz, M.J., Stress Response Syndromes (2001), Jason Aronson New Jersey","Neto, M.L.R.; School of Medicine, Federal University of Cariri (UFCA), 284, Divine Savior Street, Downtown, Brazil; email: modesto.neto@ufca.edu.br",,Elsevier Ireland Ltd,1651781,,PSRSD,32146248,English,Psychiatry Res.,Letter,Final,Open Access,Scopus,2-s2.0-85080990295,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Yeo C., Kaushal S., Yeo D.",56706936700;57203814156;56446488700;,Enteric involvement of coronaviruses: is faecal–oral transmission of SARS-CoV-2 possible?,2020,The Lancet Gastroenterology and Hepatology,5,4,,335,337,,9,10.1016/S2468-1253(20)30048-0,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080982309&doi=10.1016%2fS2468-1253%2820%2930048-0&partnerID=40&md5=56c6741f85d7cd0f9f8854fbd3d51ea7,"Department of General Surgery, Tan Tock Seng Hospital, Singapore, 308433, South Africa","Yeo, C., Department of General Surgery, Tan Tock Seng Hospital, Singapore, 308433, South Africa; Kaushal, S., Department of General Surgery, Tan Tock Seng Hospital, Singapore, 308433, South Africa; Yeo, D., Department of General Surgery, Tan Tock Seng Hospital, Singapore, 308433, South Africa",[No abstract available],,"angiotensin converting enzyme 2; chlorine; disinfectant agent; virus RNA; COVID-19; severe acute respiratory syndrome coronavirus 2; 2019 novel coronavirus; abdominal pain; brain infection; convalescence; coronavirus disease 2019; diarrhea; disease severity; faecal oral transmission; feces analysis; fever; gastrointestinal infection; gene sequence; human; humidity; intestine infection; Middle East respiratory syndrome; nausea; Note; priority journal; SARS coronavirus; temperature; virus infectivity; virus pneumonia; virus transmission; vomiting; Betacoronavirus; complication; Coronavirus infection; feces; mouth; pathogenicity; severe acute respiratory syndrome; virology; virus shedding; Betacoronavirus; Coronavirus Infections; Diarrhea; Feces; Humans; Mouth; Pneumonia, Viral; Severe Acute Respiratory Syndrome; Virus Shedding","Chan, J.F., Kok, K.H., Zhu, Z., Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan (2020) Emerg Microbes Infect, 9, pp. 221-236; Wan, Y., Shang, J., Graham, R., Baric, R.S., Li, F., Receptor recognition by novel coronavirus from Wuhan: an analysis based on decade-long structural studies of SARS (2020) J Virol, , published online Jan 29; WHO issues consensus document on the epidemiology of SARS (2003) Wkly Epidemiol Rec, 78, pp. 373-375; Chan, K.H., Poon, L.L., Cheng, V.C., Detection of SARS coronavirus in patients with suspected SARS (2004) Emerg Infect Dis, 10, pp. 294-299; Assiri, A., Al-Tawfiq, J.A., Al-Rabeeah, A.A., Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study (2013) Lancet Infect Dis, 13, pp. 752-761; Mackay, I.M., Arden, K.E., MERS coronavirus: diagnostics, epidemiology and transmission (2015) Virol J, 12, p. 222; Corman, V.M., Albarrak, A.M., Omrani, A.S., Viral shedding and antibody response in 37 patients with Middle East respiratory syndrome coronavirus infection (2016) Clin Infect Dis, 62, pp. 477-483; Zhou, J., Li, C., Zhao, G., Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus (2017) Sci Adv, 3; Wang, D., Hu, B., Hu, C., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China (2020) JAMA, , published online Feb 7; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395, pp. 507-513; Holshue, M.L., DeBolt, C., Lindquist, S., First case of 2019 novel coronavirus in the United States (2020) N Engl J Med, , published online Jan 31; Wang, X.W., Li, J., Guo, T., Concentration and detection of SARS coronavirus in sewage from Xiao Tang Shan Hospital and the 309th Hospital of the Chinese People's Liberation Army (2005) Water Sci Technol, 52, pp. 213-221; Chan, K.H., Peiris, J.S., Lam, S.Y., Poon, L.L., Yuen, K.Y., Seto, W.H., The effects of temperature and relative humidity on the viability of the SARS coronavirus (2011) Adv Virol, 2011; van Doremalen, N., Bushmaker, T., Munster, V.J., Stability of Middle East respiratory syndrome coronavirus (MERS-CoV) under different environmental conditions (2013) Euro Surveill, 18; Geller, C., Varbanov, M., Duval, R.E., Human coronaviruses: insights into environmental resistance and its influence on the development of new antiseptic strategies (2012) Viruses, 4, pp. 3044-3068",,,Elsevier Ltd,24681253,,,32087098,English,Lancet Gastroenterol. Hepatol.,Note,Final,Open Access,Scopus,2-s2.0-85080982309,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Cordes A.K., Heim A.",57215423729;56273337100;,"Rapid random access detection of the novel SARS-coronavirus-2 (SARS-CoV-2, previously 2019-nCoV) using an open access protocol for the Panther Fusion",2020,Journal of Clinical Virology,125,,104305,,,,,10.1016/j.jcv.2020.104305,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080887451&doi=10.1016%2fj.jcv.2020.104305&partnerID=40&md5=3edf9dcb36fff2b124eb7b8f8d9c02b9,"Institute for Virology, Hannover Medical School, Carl-Neuberg-Str. 1, Hannover, 30625, Germany","Cordes, A.K., Institute for Virology, Hannover Medical School, Carl-Neuberg-Str. 1, Hannover, 30625, Germany; Heim, A., Institute for Virology, Hannover Medical School, Carl-Neuberg-Str. 1, Hannover, 30625, Germany",[No abstract available],2019-nCoV; Coronavirus; COVID-19; Random access PCR; Rapid diagnosis; SARS-CoV-2,2019 novel coronavirus; Coronavirinae; Letter; nonhuman; priority journal; SARS coronavirus; virus detection,"Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395, pp. 507-513; Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N. Engl. J. Med., 382, pp. 727-733; Ganzenmueller, T., Kaiser, R., Baier, C., Wehrhane, M., Hilfrich, B., Witthuhn, J., Comparison of the performance of the Panther Fusion respiratory virus panel to R-Gene and laboratory developed tests for diagnostic and hygiene screening specimens from the upper and lower respiratory tract (2020) J. Med. Microbiol., , in press; Novak-Weekley, S.M., Marlowe, E.M., Poulter, M., Dwyer, D., Speers, D., Rawlinson, W., Evaluation of the Cepheid Xpert Flu Assay for rapid identification and differentiation of influenza A, influenza A 2009 H1N1, and influenza B viruses (2012) J. Clin. Microbiol., 50, pp. 1704-1710; Corman, V.M., Landt, O., Kaiser, M., Molenkamp, R., Meijer, A., Chu, D.K., Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR (2020) Euro Surveill., 25; (2020), Instructions for Use: LightMix Modular SARS and Wuhan CoV E-gene. Berlin: TIB MolBiol. Cat.-No. 53-0776-96, V200112; Sam, S.S., Caliendo, A.M., Ingersoll, J., Abdul-Ali, D., Hill, C.E., Kraft, C.S., Evaluation of performance characteristics of panther fusion assays for detection of respiratory viruses from nasopharyngeal and lower respiratory tract specimens (2018) J. Clin. Microbiol., 56; Chan, J.F., Yuan, S., Kok, K.H., To, K.K., Chu, H., Yang, J., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, 395, pp. 514-523","Heim, A.; Institute for Virology, Hannover Medical School, Carl-Neuberg-Str. 1, Germany; email: heim.albert@mh-hannover.de",,Elsevier B.V.,13866532,,JCVIF,,English,J. Clin. Virol.,Letter,Final,Open Access,Scopus,2-s2.0-85080887451,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Shah A., Kashyap R., Tosh P., Sampathkumar P., O'Horo J.C.",57204055450;57207952891;8244043400;6603742479;35485047600;,Guide to Understanding the 2019 Novel Coronavirus,2020,Mayo Clinic Proceedings,95,4,,646,652,,,10.1016/j.mayocp.2020.02.003,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080126011&doi=10.1016%2fj.mayocp.2020.02.003&partnerID=40&md5=1bc91c1b808f30d4b379584b2a0441d1,"Division of Infectious Diseases, Mayo Clinic, Mayo Clinic, Rochester, MN, United States; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Mayo Clinic, Rochester, MN, United States; Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Mayo Clinic, Rochester, MN, United States","Shah, A., Division of Infectious Diseases, Mayo Clinic, Mayo Clinic, Rochester, MN, United States; Kashyap, R., Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Mayo Clinic, Rochester, MN, United States; Tosh, P., Division of Infectious Diseases, Mayo Clinic, Mayo Clinic, Rochester, MN, United States; Sampathkumar, P., Division of Infectious Diseases, Mayo Clinic, Mayo Clinic, Rochester, MN, United States; O'Horo, J.C., Division of Infectious Diseases, Mayo Clinic, Mayo Clinic, Rochester, MN, United States, Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Mayo Clinic, Rochester, MN, United States",[No abstract available],,2019 novel coronavirus; case fatality rate; China; clinical feature; Coronavirinae; Coronavirus infection; epidemic; human; laboratory test; Middle East respiratory syndrome coronavirus; nonhuman; public health; SARS coronavirus; Short Survey; virus replication; virus strain; virus transmission,"Chan, J.F., Lau, S.K., To, K.K., Cheng, V.C., Woo, P.C., Yuen, K.Y., Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease (2015) Clin Microbiol Rev, 28 (2), pp. 465-522; Imai, N., Dorigatti, I., Cori, A., Riley, S., Ferguson, N.M., Estimating the potential total number of novel coronavirus (COVID-19) cases in Wuhan City, China (2020), Imperial College London London, UK; Novel coronavirus (COVID-19). World Health Organization website (2020), https://www.who.int/emergencies/diseases/novel-coronavirus-2019, (Accessed 27 January 2020); Christian, M.D., Poutanen, S.M., Loutfy, M.R., Muller, M.P., Low, D.E., Severe acute respiratory syndrome (2004) Clin Infect Dis, 38 (10), pp. 1420-1427; Peiris, J.S., Yuen, K.Y., Osterhaus, A.D., Stohr, K., The severe acute respiratory syndrome (2003) N Engl J Med, 349 (25), pp. 2431-2441; World Health Organization, (2020), http://www.who.int/csr/sars/country/table2004_04_21/en/index.html, Summary of probable SARS cases with onset of illness from 1 November 2002 to 31 July 2003. World Health Organization website. Accessed January 27; Park, B.J., Peck, A.J., Kuehnert, M.J., Lack of SARS transmission among healthcare workers, United States (2004) Emerg Infect Dis, 10 (2), pp. 244-248; Sampathkumar, P., Temesgen, Z., Smith, T.F., Thompson, R.L., SARS: epidemiology, clinical presentation, management, and infection control measures (2003) Mayo Clin Proc, 78 (7), pp. 882-890; Agostini, M.L., Andres, E.L., Sims, A.C., Coronavirus susceptibility to the antiviral remdesivir (GS-5734) is mediated by the viral polymerase and the proofreading exoribonuclease (2018) mBio, 9 (2), pp. e00221-e00228; Zaki, A.M., van Boheemen, S., Bestebroer, T.M., Osterhaus, A.D., Fouchier, R.A., Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia [published correstion appears in N Engl J Med. 2013;369(4):394] (2012) N Engl J Med, 367 (19), pp. 1814-1820; Sampathkumar, P., Middle East respiratory syndrome: what clinicians need to know (2014) Mayo Clin Proc, 89 (8), pp. 1153-1158; Arabi, Y.M., Balkhy, H.H., Hayden, F.G., Middle East respiratory syndrome (2017) N Engl J Med, 376 (6), pp. 584-594; Lesson 6: Investigating an outbreak. Centers for Disease Control and Prevention website https://www.cdc.gov/csels/dsepd/ss1978/lesson6/section2.html, (Accessed 27 January 2020); Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China [published online ahead of print January 24, 2020] Lancet; Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 [published online ahead of print January 24, 2020] N Engl J Med; Wang, D., Hu, B., Hu, C., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. [published online ahead of print February 7, 2020] JAMA; 2019 Novel coronavirus: interim guidance for healthcare professionals. Centers for Disease Control and Prevention website https://www.cdc.gov/coronavirus/2019-ncov/hcp/clinical-criteria.html, Updated February 12, 2020. Accessed February 12, 2020; World Health Organization, Infection prevention and control. World Health Organization website (2020), https://www.who.int/csr/disease/coronavirus_infections/prevention_control/en/, (Accessed 27 January 2020); Rothe, C., Schunk, M., Sothmann, P., Transmission of 2019-nCoV infection from an asymptomatic contact in Germany [published online ahead of print January 30, 2020] (2020) N Engl J Med; Yanan, W., Moritsugu, K., Human-to-human transmission confirmed in China coronavirus. AP News website https://apnews.com/14d7dcffa205d9022fa9ea593bb2a8c5, PublishedJanuary 19, 2020. Accessed Januray 19, 2020; Roos, R., Estimates of SARS death rates revised upward. University of Minnesota Center for Infectious Disease Research and Policy website http://www.cidrap.umn.edu/news-perspective/2003/05/estimates-sars-death-rates-revised-upward, Published May 7, 2003. Accessed Januray 27, 2020; Interim laboratory biosafety guidelines for handling and processing specimens associated with 2019 novel coronavirus (COVID-19). Centers for Disease Control and Prevention website https://www.cdc.gov/coronavirus/COVID-19/lab-biosafety-guidelines.html, Reviewed February 2, 2020. Accessed January 17, 2020; Wuhan Tianhe Airport was put into operation on April 15, 1995. CNHubei website https://web.archive.org/web/20171107024254/http://www.cnhubei.com/xwzt/2008zt/hbgg30y/bhdss/tianhe/fazhan/200804/t287403.shtml, Published April 17, 2008. Accessed Januray 27, 2020; Statistics of key performance indicators for China's civil aviation industry in October 2019. Civil Aviation Administration of China website http://www.caac.gov.cn/en/HYYJ/SJ/201912/t20191223_199948.html, Updated December 23, 2019. Accessed January 27, 2020; Coronavirus, what airport measures are in place to detect sick passengers? The Guardian website https://www.theguardian.com/world/2020/jan/18/coronavirus-what-airport-measures-are-in-place-to-detect-for-sick-passengers, Published January 18, 2020. Accessed January 27, 2020; Ahmed, I., Roxburgh, H., US confirms first case of China virus as death toll reaches six. International Business Times website https://www.ibtimes.com/china-says-virus-spreading-between-humans-who-set-meet-2906266, Published January 21, 2020. Accessed January 27, 2020; Coronavirus: a visual guide to the outbreak. BBC News website https://www.bbc.com/news/world-51235105, Updated February 7, 2020. Accessed January 27, 2020; Talmazan, Y., Baculinao, E., Chen, L., Abbas, M., China coronavirus death toll climbs to 106 as government scrambles to contain outbreak. NBC News website https://www.nbcnews.com/news/world/china-coronavirus-death-toll-climbs-80-government-scrambles-contain-outbreak-n1123561, Published January 27, 2020. Updated January 28, 2020. Accessed January 27, 2020","Shah, A.; Division of Infectious Diseases, Mayo Clinic, 200 First St SW, United States; email: shah.aditya@mayo.edu",,Elsevier Ltd,256196,,MACPA,32122636,English,Mayo Clin. Proc.,Short Survey,Final,Open Access,Scopus,2-s2.0-85080126011,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Zhou X.,57215208217;,Psychological crisis interventions in Sichuan Province during the 2019 novel coronavirus outbreak,2020,Psychiatry Research,286,,112895,,,,,10.1016/j.psychres.2020.112895,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080081887&doi=10.1016%2fj.psychres.2020.112895&partnerID=40&md5=f7c846c364775934fc02b54f37fde8bf,"Department of Psychosomatics, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, 610072, China","Zhou, X., Department of Psychosomatics, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, 610072, China",[No abstract available],,China; coronavirus disease 2019; Coronavirus infection; disease transmission; Ebola hemorrhagic fever; emotional disorder; epidemic; fear; guilt; health hazard; helplessness; human; infection control; influenza A (H1N1); Letter; medical personnel; mental disease; mixed anxiety and depression; poliomyelitis; population structure; priority journal; virus infectivity; Zika fever,,,,Elsevier Ireland Ltd,1651781,,PSRSD,,English,Psychiatry Res.,Letter,Final,Open Access,Scopus,2-s2.0-85080081887,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Li J., Liu W.",55973342600;57049902700;,Puzzle of highly pathogenic human coronaviruses (2019-nCoV),2020,Protein and Cell,11,4,,235,238,,,10.1007/s13238-020-00693-y,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079758648&doi=10.1007%2fs13238-020-00693-y&partnerID=40&md5=34987ce0c927042b9ca370e249420401,"CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China; University of Chinese Academy of Sciences, Beijing, 100049, China; Institute of Microbiology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Beijing, 100101, China","Li, J., CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China, University of Chinese Academy of Sciences, Beijing, 100049, China; Liu, W., CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China, University of Chinese Academy of Sciences, Beijing, 100049, China, Institute of Microbiology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Beijing, 100101, China",[No abstract available],,,"Benvenuto, D., Giovanetti, M., Ciccozzi, A., Spoto, S., Angeletti, S., Ciccozzi, M., (2020) The 2019-New Coronavirus Epidemic: Evidence for Virus Evolution, , bioRxiv; Chan, J.-W., Yuan, S., Kok, K.-H., To, K.-W., Chu, H., Yang, J., Xing, F., Poon, R.-S., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: A study of a family cluster (2020) Lancet; Chen, T., Rui, J., Wang, Q., Zhao, Z., Cui, J.-A., Yin, L., (2020) A Mathematical Model for Simulating the Transmission of Wuhan Novel Coronavirus, , bioRxiv; Chen, Z., Zhang, W., Lu, Y., Guo, C., Guo, Z., Liao, C., Zhang, X., Li, Q., (2020) From SARS-CoV to Wuhan 2019-nCoV outbreak: Similarity of early epidemic and prediction of future trends, , bioRxiv; Cinatl, J., Morgenstern, B., Bauer, G., Chandra, P., Rabenau, H., Doerr, H.W., Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus (2003) Lancet, 361, pp. 2045-2046. , COI: 1:CAS:528:DC%2BD3sXksF2hu78%3D; Cinatl, J., Morgenstern, B., Bauer, G., Chandra, P., Rabenau, H., Doerr, H.W., Treatment of SARS with human interferons (2003) Lancet, 362, pp. 293-294. , COI: 1:CAS:528:DC%2BD3sXlvVSmsLg%3D; Dong, N., Yang, X., Ye, L., Chen, K., Chan, E.-C., Yang, M., Chen, S., Genomic and protein structure modelling analysis depicts the origin and infectivity of 2019-nCoV (2020) A New Coronavirus Which Caused a Pneumonia Outbreak in Wuhan, , China. bioRxiv; Guo, Q., Li, M., Wang, C., Fang, Z., Wang, P., Tan, J., Wu, S., Zhu, H., (2020) Host and infectivity prediction of Wuhan 2019 novel coronavirus using deep learning algorithm., , bioRxiv; Haagmans, B.L., Kuiken, T., Martina, B.E., Fouchier, R.A., Rimmelzwaan, G.F., van Amerongen, G., van Riel, D., Chan, K.H., Pegylated interferon-alpha protects type 1 pneumocytes against SARS coronavirus infection in macaques (2004) Nat Med, 10, pp. 290-293. , COI: 1:CAS:528:DC%2BD2cXhs1WntbY%3D; Hilgenfeld, R., Peiris, M., From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses (2013) Antiviral Res, 100, pp. 286-295. , COI: 1:CAS:528:DC%2BC3sXhvVWltbbK; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Gu, X., (2020) Clinical Features of Patients Infected with 2019 Novel Coronavirus in Wuhan, , China, Lancet; Ji, W., Wang, W., Zhao, X., Zai, J., Li, X., Homologous recombination within the spike glycoprotein of the newly identified coronavirus may boost cross-species transmission from snake to human (2020) J Med Virol; Letko, M., Munster, V., (2020) Functional Assessment of Cell Entry and Receptor Usage for Lineage B β-coronaviruses, , including 2019-nCoV. bioRxiv; Muth, D., Corman, V.M., Roth, H., Binger, T., Dijkman, R., Gottula, L.T., Gloza-Rausch, F., Rihtaric, D., Attenuation of replication by a 29 nucleotide deletion in SARS-coronavirus acquired during the early stages of human-to-human transmission (2018) Sci Rep, 8, p. 15177; Oostra, M., de Haan, C.A., Rottier, P.J., The 29-nucleotide deletion present in human but not in animal severe acute respiratory syndrome coronaviruses disrupts the functional expression of open reading frame 8 (2007) J Virol, 81, pp. 13876-13888. , COI: 1:CAS:528:DC%2BD2sXhsValsbfO; Paules, C.I., Marston, H.D., Fauci, A.S., Coronavirus infections—more than just the common cold (2020) JAMA; Perlman, S., Another decade, another coronavirus (2020) N Engl J Med; Riou, J., Althaus, C.L., (2020) Pattern of Early Human-To-Human Transmission of Wuhan 2019-Ncov, , bioRxiv; Thompson, R.N., (2020) 2019-20 Wuhan coronavirus outbreak: Intense surveillance is vital for preventing sustained transmission in new locations, , bioRxiv; Wang, C., Horby, P.W., Hayden, F.G., Gao, G.F., A novel coronavirus outbreak of global health concern (2020) Lancet; Wu, F., Zhao, S., Yu, B., Chen, Y.-M., Wang, W., Hu, Y., Song, Z.-G., Pei, Y.-Y., (2020) Complete Genome Characterisation of a Novel Coronavirus Associated with Severe Human Respiratory Disease in Wuhan, , China. bioRxiv; Zhao, Z., Zhang, F., Xu, M., Huang, K., Zhong, W., Cai, W., Yin, Z., Wei, M., Description and clinical treatment of an early outbreak of severe acute respiratory syndrome (SARS) in Guangzhou, PR China (2003) J Med Microbiol, 52, pp. 715-720. , COI: 1:CAS:528:DC%2BD3sXntlKht7Y%3D; Zhao, S., Ran, J., Musa, S.S., Yang, G., Lou, Y., Gao, D., Yang, L., He, D., (2020) Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: a data-driven analysis in the early phase of the outbreak, , bioRxiv; Zhao, Y., Zhao, Z., Wang, Y., Zhou, Y., Ma, Y., Zuo, W., (2020) Single-Cell RNA Expression Profiling of ACE2, the Putative Receptor of Wuhan 2019-Ncov, , bioRxiv; Zhou, P., Yang, X.-L., Wang, X.-G., Hu, B., Zhang, L., Zhang, W., Si, H.-R., Huang, C.-L., (2020) Discovery of a Novel Coronavirus Associated with the Recent Pneumonia Outbreak in Humans and Its Potential Bat Origin, , bioRxiv; Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., Zhao, X., Lu, R., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med","Li, J.; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of SciencesChina; email: lj418@163.com",,Higher Education Press,1674800X,,,32088858,English,Protein Cell,Note,Final,Open Access,Scopus,2-s2.0-85079758648,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, York A.,57208839423;,Novel coronavirus takes flight from bats?,2020,Nature Reviews Microbiology,18,4,,191,,,,10.1038/s41579-020-0336-9,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079732229&doi=10.1038%2fs41579-020-0336-9&partnerID=40&md5=23a3e03c68cc39ad5055d5cd865d9655,,"York, A.",[No abstract available],,bat; bronchoalveolar lavage fluid; coronavirus disease 2019; Coronavirus infection; hospital patient; human; metagenomics; nonhuman; Note; phylogeny; priority journal; SARS coronavirus; Severe acute respiratory syndrome coronavirus 2; thorax radiography; transcriptome sequencing; virus genome; World Health Organization,"Wu, F., A new coronavirus associated with human respiratory disease in China (2020) Nature; Zhou, P., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature; Cui, J., Li, F., Shi, Z., Origin and evolution of pathogenic coronaviruses (2019) Nat. Rev. Microbiol., 17, pp. 181-192. , COI: 1:CAS:528:DC%2BC1cXisVyhtbnL","York, A.email: nrmicro@nature.com",,Nature Research,17401526,,NRMAC,32051570,English,Nat. Rev. Microbiol.,Note,Final,Open Access,Scopus,2-s2.0-85079732229,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Kofi Ayittey F., Dzuvor C., Kormla Ayittey M., Bennita Chiwero N., Habib A.",57214899162;57203968313;57214897474;57214895653;57214892280;,Updates on Wuhan 2019 novel coronavirus epidemic,2020,Journal of Medical Virology,92,4,,403,407,,3,10.1002/jmv.25695,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079439849&doi=10.1002%2fjmv.25695&partnerID=40&md5=7bd85de406497061b789db6b2be7bbec,"Department of Chemical Engineering, Curtin University Malaysia, Sarawak, Malaysia; Department of Chemical Engineering, Monash University, Clayton, VIC, Australia; Agricultural Extension Office, Ministry of Food and Agriculture, Adidome, Ghana; Urological Division, Ghana Health Service, Sogakope, Ghana","Kofi Ayittey, F., Department of Chemical Engineering, Curtin University Malaysia, Sarawak, Malaysia; Dzuvor, C., Department of Chemical Engineering, Monash University, Clayton, VIC, Australia; Kormla Ayittey, M., Agricultural Extension Office, Ministry of Food and Agriculture, Adidome, Ghana; Bennita Chiwero, N., Department of Chemical Engineering, Curtin University Malaysia, Sarawak, Malaysia; Habib, A., Urological Division, Ghana Health Service, Sogakope, Ghana",[No abstract available],,2019 novel coronavirus; 2019 novel coronavirus epidemic; Betacoronavirus; China; Coronavirus infection; health care facility; human; incubation time; infection control; infection prevention; leisure; market; migrant worker; Note; pneumonia; quarantine; quarantine station; sequence analysis; traffic and transport; travel; virus isolation; virus pathogenesis; virus transmission; World Health Organization; Betacoronavirus; Coronavirinae; Coronavirus infection; pneumonia; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; Coronavirus; Coronavirus Infections; Humans; Pneumonia,"https://www.caixinglobal.com/2020-01-31/wuhan-virus-latest-china-reports-second-pneumonia-linked-death-101505300.html, Accessed Feb 1, 2020; Wang, C., Horby, P.W., Hayden, F.G., Gao, G.F., A novel coronavirus outbreak of global health concern (2020) The Lancet; Horton, R., Offline: 2019-nCoV outbreak—early lessons (2020) The Lancet, 395, p. 322; Luo, G., Gao, S.-J., Global health concern stirred by emerging viral infections (2020) J Med Virol, , https://doi.org/10.1002/jmv.25683; Lu, H., Stratton, C.W., Tang, Y.-W., Outbreak of pneumonia of unknown etiology in Wuhan China: the mystery and the miracle (2020) J Med Virol, , https://doi.org/10.1002/jmv.25678; Woo, P.C.Y., Lau, S.K.P., Lam, C.S.F., Discovery of seven novel mammalian and avian coronaviruses in the genus deltacoronavirus supports bat coronaviruses as the gene source of alphacoronavirus and betacoronavirus and avian coronaviruses as the gene source of gammacoronavirus and deltacoronavirus (2012) J Virol, 86 (7), pp. 3995-4008; Lai, M.M.C., Holmes, K.V., Coronaviridae: the viruses and their replication Fields (2001) Fields virology Lippincott-Raven Philadephia, 1163, p. 1185. , BN, Knipe DM, Howley PM, eds; https://talk.ictvonline.org/taxonomy/, Accessed Jan 31, 2020; Li, G., Fan, Y., Lai, Y., Coronavirus infections and immune responses (2020) J Med Virol, , https://doi.org/10.1002/jmv.25685; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) The Lancet; Zhang, N., Wang, L., Deng, X., Recent advances in the detection of respiratory virus infection in humans (2020) J Med Virol, , https://doi.org/10.1002/jmv.25674; Chen, Y., Liu, Q., Guo, D., Emerging coronaviruses: genome structure, replication, and pathogenesis (2020) J Med Virol, , https://doi.org/10.1002/jmv.25681; Cohen, J., (2020) Chinese Researchers Reveal Draft Genome of Virus Implicated in Wuhan Pneumonia Outbreak, , https://www.sciencemag.org/news/2020/01/chinese-researchersreveal-draft-genome-virus-implicated-wuhan-pneumonia-outbreak, Washington, DC, American Association for the Advancement of Science; Chan, J.F.W., Yuan, S., Kok, K.H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) The Lancet; https://www.nytimes.com/2020/01/25/world/asia/china-coronavirus.html, Accessed Jan 27, 2020; (2020) CHP provides further information on cluster of pneumonia cases in Wuhan, , https://www.info.gov.hk/gia/general/202001/12/P2020011200710.htm, Accessed Jan 21, 2020; Wang, W., Tang, J., Wei, F., Updated understanding of the outbreak of 2019 novel coronavirus (2019-nCoV) in Wuhan, China (2020) J Med Virol, , https://doi.org/10.1002/jmv.25689; https://www.theguardian.com/science/2020/jan/26/coronavirus-could-infect-100000-globally-experts-warn, Accessed Jan 28, 2020; Wu, J.T., Leung, K., Leung, G.M., Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study (2020) The Lancet; https://www.reuters.com/article/china-health-official-idUSL4N29Z42X, Accessed Feb 1, 2020; https://www.china-briefing.com/news/china-extends-lunar-new-year-holiday-february-2-shanghai-february-9-contain-coronavirus-outbreak/, Accessed Feb 1, 2020; https://twitter.com/globaltimesnews/status/1223218977570078721, Accessed Feb 1, 2020; https://www.scmp.com/week-asia/health-environment/article/3047821/amid-wuhan-virus-fears-asia-pacific-countries-weigh, Accessed Jan 28, 2020; https://edition.cnn.com/2020/01/30/asia/wuhan-coronavirus-update-intl-hnk/index.html, Accessed Feb 1, 2020; http://www.chinadaily.com.cn/a/202002/01/WS5e34be5da310128217273ef5.html, Accessed Feb 1, 2020; https://edition.cnn.com/2020/01/29/world/wuhan-coronavirus-evacuations-intl/index.html, Accessed Feb 1, 2020; https://www.bbc.com/news/world-51318246, Accessed Feb 1, 2020; https://en.m.wikipedia.org/wiki/Novel_coronavirus_(2019-nCoV, Accessed Feb 1, 2020; Steenhuysen, J., Kelland, K., With Wuhan virus genetic code in hand, scientists begin work on a vaccine 2020, , https://www.reuters.com/article/us-china-health-vaccines-idUSKBN1ZN2J8, Accessed Feb 1, 2020; Novel coronavirus (2019-nCoV) advice for the public, , https://www.who.int/emergencies/diseases/novel-coronavirus-2019/advice-for-public, Accessed Feb 1, 2020","Kofi Ayittey, F.; Department of Chemical Engineering, Curtin University MalaysiaMalaysia; email: Ayittey.FosterKofi@postgrad.curtin.edu.my",,John Wiley and Sons Inc.,1466615,,JMVID,32017153,English,J. Med. Virol.,Note,Final,Open Access,Scopus,2-s2.0-85079439849,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Jansson M., Liao X., Rello J.",55358994000;8320293500;55651028100;,Strengthening ICU health security for a coronavirus epidemic,2020,Intensive and Critical Care Nursing,57,,102812,,,,2,10.1016/j.iccn.2020.102812,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079166978&doi=10.1016%2fj.iccn.2020.102812&partnerID=40&md5=da4ec15233f526601afe2fdb918e2350,"Research Group of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland; Oulu University Hospital, Oulu, Finland; Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China; Vall d'Hebron Institute of Research & Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Barcelona, Spain; Clinical Research Department, CHU Nîmes, University Montpellier-Nîmes, Nîmes, France","Jansson, M., Research Group of Medical Imaging, Physics and Technology, University of Oulu, Oulu, Finland, Oulu University Hospital, Oulu, Finland; Liao, X., Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China; Rello, J., Vall d'Hebron Institute of Research & Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Barcelona, Spain, Clinical Research Department, CHU Nîmes, University Montpellier-Nîmes, Nîmes, France",[No abstract available],,,"CDC, Key Measures for SARS Preparedness and Response (2004), https://www.cdc.gov/sars/guidance/core/keymeasures.html, Available at:; https://www.cdc.gov/coronavirus/2019-nCoV/summary.html, CDC 2019. 2019 Novel Coronavirus (2019-nCoV), Wuhan, China. Available at:; Loutfy, M.R., Wallington, T., Rutledge, T., Mederski, B., Rose, K., Kwolek, S., Hospital preparedness and SARS (2004) Emerg. Infect. Dis., 10 (5), pp. 771-776; WHO, Hospital infection control guidance for Severe Acute Respiratory Syndrome (SARS) (2005), https://www.who.int/ihr/lyon/surveillance/infectioncontrol/en/, Available at:; WHO, Infection prevention and control of epidemic-and pandemic prone acute respiratory infections in health care (2014), https://www.who.int/csr/bioriskreduction/infection_control/publication/en/, Available at:; WHO, Infection prevention and control during health care when novel coronavirus (nCoV) infection is suspected (2020), https://www.who.int/publications-detail/infection-prevention-and-control-during-health-care-when-novel-coronavirus-(ncov)-infection-is-suspected, Available at:; https://www.who.int/publications-detail/global-surveillance-for-human-infection-with-novel-coronavirus-(2019-ncov), WHO 2020b. Global Surveillance for human infection with novel coronavirus (2019-nCoV) Available at:",,,Churchill Livingstone,9643397,,,32044122,English,Intensive Crit. Care Nurs.,Editorial,Final,Open Access,Scopus,2-s2.0-85079166978,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Benvenuto D., Giovanetti M., Vassallo L., Angeletti S., Ciccozzi M.",57208408457;55486066500;57215496011;7003426796;8791594200;,Application of the ARIMA model on the COVID-2019 epidemic dataset,2020,Data in Brief,29,,105340,,,,,10.1016/j.dib.2020.105340,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081033339&doi=10.1016%2fj.dib.2020.105340&partnerID=40&md5=c1225da4928df5b419e9f0bd4e83d560,"Unit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome, Italy; Laboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil; Department of Financial and Statistical Sciences, University of Salerno, Salerno, Italy; Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome, Italy","Benvenuto, D., Unit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome, Italy; Giovanetti, M., Laboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil; Vassallo, L., Department of Financial and Statistical Sciences, University of Salerno, Salerno, Italy; Angeletti, S., Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome, Italy; Ciccozzi, M., Laboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil","Coronavirus disease 2019 (COVID-2019) has been recognized as a global threat, and several studies are being conducted using various mathematical models to predict the probable evolution of this epidemic. These mathematical models based on various factors and analyses are subject to potential bias. Here, we propose a simple econometric model that could be useful to predict the spread of COVID-2019. We performed Auto Regressive Integrated Moving Average (ARIMA) model prediction on the Johns Hopkins epidemiological data to predict the epidemiological trend of the prevalence and incidence of COVID-2019. For further comparison or for future perspective, case definition and data collection have to be maintained in real time. © 2020 The Authors",ARIMA model; COVID-2019 epidemic; Forecast; Infection control,,"(2019) Johns Hopkins University Center for Systems Science and Engineering, , https://github.com/CSSEGISandData/COVID-19; Fattah, J., Ezzine, L., Aman, Z., El Moussami, H., Lachhab, A., Forecasting of demand using ARIMA model (2018) Int. J. Eng. Bus. Manag., 10; Cao, S., Wang, F., Tam, W., Tse, L.A., Kim, J.H., Liu, J., Lu, Z., A hybrid seasonal prediction model for tuberculosis incidence in China (2013) BMC Med. Inf. Decis. Making, 13, p. 56; Cheung, Y.-W., Lai, K.S., Lag order and critical values of the augmented Dickey–Fuller test (1995) J. Bus. Econ. Stat., 13, pp. 277-280; Baiocchi, G., Distaso, W., GRETL: econometric software for the GNU generation (2003) J. Appl. Econom., 18, pp. 105-110; Wang, Y.W., Shen, Z.Z., Jiang, Y., Comparison of ARIMA and GM(1,1) models for prediction of hepatitis B in China (2018) PloS One, 13, p. e0201987","Angeletti, S.; Unit of Clinical Laboratory Science, University Campus Bio-Medico of RomeItaly; email: s.angeletti@unicampus.it",,Elsevier Inc.,23523409,,,,English,Data Brief,Data Paper,Final,Open Access,Scopus,2-s2.0-85081033339,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Li H., Li J., Zhai Y., Zhang L., Cui P., Feng L., Yan W., Fu X., Tian Y., Wang H., Yang X.",57214117050;57112860500;57214106761;57214131418;57214128792;57195597967;57214126635;57214108889;55250777900;37021979000;56780798600;,Gga-miR-30d regulates infectious bronchitis virus infection by targeting USP47 in HD11 cells,2020,Microbial Pathogenesis,141,,103998,,,,,10.1016/j.micpath.2020.103998,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078293108&doi=10.1016%2fj.micpath.2020.103998&partnerID=40&md5=5d76b1437cbaea54afc5bd60d894e4d4,"Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, College of Life Sciences, Sichuan University, Chengdu, Sichuan 610065, China","Li, H., Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, College of Life Sciences, Sichuan University, Chengdu, Sichuan 610065, China; Li, J., Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, College of Life Sciences, Sichuan University, Chengdu, Sichuan 610065, China; Zhai, Y., Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, College of Life Sciences, Sichuan University, Chengdu, Sichuan 610065, China; Zhang, L., Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, College of Life Sciences, Sichuan University, Chengdu, Sichuan 610065, China; Cui, P., Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, College of Life Sciences, Sichuan University, Chengdu, Sichuan 610065, China; Feng, L., Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, College of Life Sciences, Sichuan University, Chengdu, Sichuan 610065, China; Yan, W., Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, College of Life Sciences, Sichuan University, Chengdu, Sichuan 610065, China; Fu, X., Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, College of Life Sciences, Sichuan University, Chengdu, Sichuan 610065, China; Tian, Y., Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, College of Life Sciences, Sichuan University, Chengdu, Sichuan 610065, China; Wang, H., Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, College of Life Sciences, Sichuan University, Chengdu, Sichuan 610065, China; Yang, X., Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, College of Life Sciences, Sichuan University, Chengdu, Sichuan 610065, China","Avian infectious bronchitis virus (IBV) is a coronavirus which infects chickens and causes severe economic losses to the poultry industry worldwide. MicroRNAs (miRNAs) are important intracellular regulators and play a pivotal role in viral infections. In previous studies, we have revealed that IBV infection caused a significant down-regulation of gga-miR-30d expression in chicken kidneys. In present study, we investigated the role of gga-miR-30d in the process of IBV infection of HD11 cell line in vitro. By transfecting the mimics and inhibitor of gga-miR-30d, it was found that overexpressed gga-miR-30d inhibited IBV replication. Contrarily, low-expressed gga-miR-30d promoted IBV replication. In addition, dual-luciferase reporter assays revealed that ubiquitin-specific protease 47 (USP47), a deubiquitinase-encoding gene, was a target for gga-miR-30d. This is the first study demonstrating that miRNAs regulate IBV replication by regulating the deubiquitinating enzyme (DUBs). © 2020 Elsevier Ltd",HD11; IBV; miR-gga-30d; USP47,deubiquitinase; microRNA; microRNA 30d; ubiquitin specific protease 47; unclassified drug; 3' untranslated region; animal cell; Article; avian infectious bronchitis; Avian infectious bronchitis virus; controlled study; deubiquitination; Gallus gallus; gene control; gene function; gene overexpression; gene targeting; genetic transfection; in vitro study; LSCC-HD11 cell line; luciferase assay; nonhuman; priority journal; virus pathogenesis; virus replication,"Cook, J.K., Jackwood, M., Jones, R.C., The long view: 40 years of infectious bronchitis research (2012) Avian Pathol., 41 (3), pp. 239-250; Hawn, S.A.F.M.C., An apparently new respiratory disease of baby chicks (1931) J. Am. Vet. Med. Assoc., p. 78; Awad, F., Chhabra, R., Baylis, M., Ganapathy, K., An overview of infectious bronchitis virus in chickens (2014) World Poultry Sci. J., 70 (2), pp. 375-383; Cavanagh, D., Coronavirus avian infectious bronchitis virus (2007) Vet. Res., 38 (2), pp. 281-297; He, K., Li, M., Wei, P., Mo, M.L., Wei, T.C., Li, K.R., Complete genome sequence of an infectious bronchitis virus chimera between cocirculating heterotypic strains (2012) J. Virol., 86 (24), pp. 13887-13888; Yao, Y., Charlesworth, J., Nair, V., Watson, M., MicroRNA expression profiles in avian haemopoietic cells (2013) Front. Genet., 4, p. 153; Yao, Y., Nair, V., Role of virus-encoded microRNAs in Avian viral diseases (2014) Viruses, 6 (3), pp. 1379-1394; Bernier, A., Sagan, S.M., The diverse roles of microRNAs at the host-virus interface (2018) Viruses-Basel, 10 (8); Othumpangat, S., Bryan, N.B., Beezhold, D.H., Noti, J.D., Upregulation of miRNA-4776 in influenza virus infected bronchial epithelial cells is associated with downregulation of NFKBIB and increased viral survival (2017) Viruses-Basel, 9 (5); Hou, P.L., Wang, H.M., Zhao, G.M., Hu, G.X., Xia, X.Z., He, H.B., MiR-3470b promotes bovine ephemeral fever virus replication via directly targeting mitochondrial antiviral signaling protein (MAVS) in baby hamster Syrian kidney cells (2018) BMC Microbiol., 18; Hou, P.L., Zhao, M., He, W.Q., He, H.B., Wang, H.M., Cellular microRNA bta-miR-2361 inhibits bovine herpesvirus 1 replication by directly targeting EGR1 gene (2019) Vet. Microbiol., 233, pp. 174-183; Yang, X., Gao, W.Q., Liu, H., Li, J.A., Chen, D.Y., Yuan, F., Zhang, Z.K., Wang, H.N., MicroRNA transcriptome analysis in chicken kidneys in response to differing virulent infectious bronchitis virus infections (2017) Arch. Virol., 162 (11), pp. 3397-3405; Fu, Y.X., Xu, W.T., Chen, D.Y., Feng, C.H., Zhang, L., Wang, X.H., Lv, X.W., Wu, Z.W., Enterovirus 71 induces autophagy by regulating has-miR-30a expression to promote viral replication (2015) Antivir. Res., 124, pp. 43-53; Zhang, X.Z., Daucher, M., Armistead, D., Russell, R., Kottilil, S., MicroRNA expression profiling in HCV-infected human hepatoma cells identifies potential anti-viral targets induced by interferon-alpha (2013) PloS One, 8 (2); Wang, C.M., Zhang, Y.Y., Luo, J., Ding, H., Liu, S.L., Amer, S., Xie, L., He, H.X., Identification of miRNomes reveals ssc-miR-30d-R_1 as a potential therapeutic target for PRRS viral infection (2016) Sci Rep-Uk, 6; Tran, A.T., Rahim, M.N., Ranadheera, C., Kroeker, A., Cortens, J.P., Opanubi, K.J., Wilkins, J.A., Coombs, K.M., Knockdown of specific host factors protects against influenza virus-induced cell death (2013) Cell Death Dis., 4, p. e769; Sheppard, M., McHenry, E.W., The physiological properties of ascorbic acid: effects upon water balance and upon body composition of Guinea-pigs (1939) Biochem. J., 33 (5), pp. 655-657; Wang, H., Yuan, X., Sun, Y.J., Mao, X., Meng, C.C., Tan, L., Song, C.P., Liao, Y., Infectious bronchitis virus entry mainly depends on clathrin mediated endocytosis and requires classical endosomal/lysosomal system (2019) Virology, 528, pp. 118-136; Guo, H.C., Huang, M., Yuan, Q., Wei, Y.Q., Gao, Y., Mao, L.J., Gu, L.J., Sun, S.Q., The important role of lipid raft-mediated attachment in the infection of cultured cells by coronavirus infectious bronchitis virus beaudette strain (2017) PloS One, 12 (1); Tay, F.P.L., Huang, M., Wang, L., Yamada, Y., Liu, D.X., Characterization of cellular furin content as a potential factor determining the susceptibility of cultured human and animal cells to coronavirus infectious bronchitis virus infection (2012) Virology, 433 (2), pp. 421-430; Han, X.X., Tian, Y.M., Guan, R., Gao, W.Q., Yang, X., Zhou, L., Wang, H.N., Infectious bronchitis virus infection induces apoptosis during replication in chicken macrophage HD11 cells (2017) Viruses-Basel, 9 (8); Fung, T.S., Liu, D.X., Coronavirus infection, ER stress, apoptosis and innate immunity (2014) Front. Microbiol., 5, p. 296; Liu, H., Yang, X., Zhang, Z.K., Zou, W.C., Wang, H.N., miR-146a-5p promotes replication of infectious bronchitis virus by targeting IRAK2 and TNFRSF18 (2018) Microb. Pathog., 120, pp. 32-36; Isaacson, M.K., Ploegh, H.L., Ubiquitination, ubiquitin-like modifiers, and deubiquitination in viral infection (2009) Cell Host Microbe, 5 (6), pp. 559-570; Gu, Z., Shi, W., Manipulation of viral infection by deubiquitinating enzymes: new players in host-virus interactions (2016) Future Microbiol., 11, pp. 1435-1446; Parsons, J.L., Dianova, I.I., Khoronenkova, S.V., Edelmann, M.J., Kessler, B.M., Dianov, G.L., USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase beta (2011) Mol. Cell, 41 (5), pp. 609-615; Setz, C., Friedrich, M., Rauch, P., Fraedrich, K., Matthaei, A., Traxdorf, M., Schubert, U., Inhibitors of deubiquitinating enzymes block HIV-1 replication and augment the presentation of gag-derived MHC-I epitopes (2017) Viruses, 9 (8); Bailey-Elkin, B.A., Knaap, R.C.M., Kikkert, M., Mark, B.L., Structure and function of viral deubiquitinating enzymes (2017) J. Mol. Biol., 429 (22), pp. 3441-3470; Zheng, D., Chen, G., Guo, B., Cheng, G., Tang, H., PLP2, a potent deubiquitinase from murine hepatitis virus, strongly inhibits cellular type I interferon production (2008) Cell Res., 18 (11), pp. 1105-1113; Frieman, M., Ratia, K., Johnston, R.E., Mesecar, A.D., Baric, R.S., Severe acute respiratory syndrome coronavirus papain-like protease ubiquitin-like domain and catalytic domain regulate antagonism of IRF3 and NF-kappaB signaling (2009) J. Virol., 83 (13), pp. 6689-6705; Sun, L., Xing, Y., Chen, X., Zheng, Y., Yang, Y., Nichols, D.B., Clementz, M.A., Chen, Z., Coronavirus papain-like proteases negatively regulate antiviral innate immune response through disruption of STING-mediated signaling (2012) PloS One, 7 (2); Yu, L., Zhang, X., Wu, T., Wang, Y., Meng, J., Liu, Q., Niu, X., Wu, Y., The papain-like protease of avian infectious bronchitis virus has deubiquitinating activity (2017) Arch. Virol., 162 (7), pp. 1943-1950","Yang, X.; Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, College of Life Sciences, Sichuan UniversityChina; email: yangxin0822@scu.edu.cn",,Academic Press,8824010,,MIPAE,31982568,English,Microb. Pathog.,Article,Final,Open Access,Scopus,2-s2.0-85078293108,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Shi H., Han X., Jiang N., Cao Y., Alwalid O., Gu J., Fan Y., Zheng C.",12789169600;57208739929;57215876198;57200816266;57203203402;57215874127;57215840000;16305998200;,"Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study",2020,The Lancet Infectious Diseases,20,4,,425,434,,7,10.1016/S1473-3099(20)30086-4,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082024690&doi=10.1016%2fS1473-3099%2820%2930086-4&partnerID=40&md5=c8d95aec59e648997540935730072ea9,"Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan, Hubei, China; Department of Radiology, Wuhan Jinyintan Hospital, Wuhan, Hubei, China","Shi, H., Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, Hubei, China; Han, X., Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, Hubei, China; Jiang, N., Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, Hubei, China; Cao, Y., Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, Hubei, China; Alwalid, O., Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, Hubei, China; Gu, J., Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, Hubei, China; Fan, Y., Department of Radiology, Wuhan Jinyintan Hospital, Wuhan, Hubei, China; Zheng, C., Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, Hubei Province Key Laboratory of Molecular Imaging, Wuhan, Hubei, China","Background: A cluster of patients with coronavirus disease 2019 (COVID-19) pneumonia caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were successively reported in Wuhan, China. We aimed to describe the CT findings across different timepoints throughout the disease course. Methods: Patients with COVID-19 pneumonia (confirmed by next-generation sequencing or RT-PCR) who were admitted to one of two hospitals in Wuhan and who underwent serial chest CT scans were retrospectively enrolled. Patients were grouped on the basis of the interval between symptom onset and the first CT scan: group 1 (subclinical patients; scans done before symptom onset), group 2 (scans done ≤1 week after symptom onset), group 3 (>1 week to 2 weeks), and group 4 (>2 weeks to 3 weeks). Imaging features and their distribution were analysed and compared across the four groups. Findings: 81 patients admitted to hospital between Dec 20, 2019, and Jan 23, 2020, were retrospectively enrolled. The cohort included 42 (52%) men and 39 (48%) women, and the mean age was 49·5 years (SD 11·0). The mean number of involved lung segments was 10·5 (SD 6·4) overall, 2·8 (3·3) in group 1, 11·1 (5·4) in group 2, 13·0 (5·7) in group 3, and 12·1 (5·9) in group 4. The predominant pattern of abnormality observed was bilateral (64 [79%] patients), peripheral (44 [54%]), ill-defined (66 [81%]), and ground-glass opacification (53 [65%]), mainly involving the right lower lobes (225 [27%] of 849 affected segments). In group 1 (n=15), the predominant pattern was unilateral (nine [60%]) and multifocal (eight [53%]) ground-glass opacities (14 [93%]). Lesions quickly evolved to bilateral (19 [90%]), diffuse (11 [52%]) ground-glass opacity predominance (17 [81%]) in group 2 (n=21). Thereafter, the prevalence of ground-glass opacities continued to decrease (17 [57%] of 30 patients in group 3, and five [33%] of 15 in group 4), and consolidation and mixed patterns became more frequent (12 [40%] in group 3, eight [53%] in group 4). Interpretation: COVID-19 pneumonia manifests with chest CT imaging abnormalities, even in asymptomatic patients, with rapid evolution from focal unilateral to diffuse bilateral ground-glass opacities that progressed to or co-existed with consolidations within 1–3 weeks. Combining assessment of imaging features with clinical and laboratory findings could facilitate early diagnosis of COVID-19 pneumonia. Funding: None. © 2020 Elsevier Ltd",,C reactive protein; serum amyloid A; adult; aged; Article; asymptomatic infection; China; clinical feature; comorbidity; Coronavirinae; coronavirus disease 2019; Coronavirus infection; digital imaging and communications in medicine; disease course; early diagnosis; female; human; laboratory test; leukocytosis; lymphocytosis; major clinical study; male; middle aged; pleura effusion; priority journal; retrospective study; severe acute respiratory syndrome coronavirus 2; thorax radiography; virus pneumonia; x-ray computed tomography,"Novel coronavirus—China (2020), https://www.who.int/csr/don/12-january-2020-novel-coronavirus-china/en/, (Accessed 12 February 2020); Coronavirus disease (COVID-19) outbreak (2020), https://www.who.int/emergencies/diseases/novel-coronavirus-2019, (Accessed 15 February 2020); Xu, X., Chen, P., Wang, J., Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission (2020) Sci China Life Sci, , published online Jan 21; Tan, W., Zhao, X., Ma, X., Notes from the field: a novel coronavirus genome identified in a cluster of pneumonia cases—Wuhan, China 2019–2020 (2020) China CDC Weekly, 2, pp. 61-62; Na, Z., Ding, Z., Wen, W., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-605; Novel coronavirus—Thailand (ex-China) (2020), https://www.who.int/csr/don/14-january-2020-novel-coronavirus-thailand/en/, (Accessed 8 February 2020); Novel coronavirus—Japan (ex-China) (2020), https://www.who.int/csr/don/17-january-2020-novel-coronavirus-japan-ex-china/en/, (Accessed 19 January 2020); Novel coronavirus—Republic of Korea (ex-China) (2020), https://www.who.int/csr/don/21-january-2020-novel-coronavirus-republic-of-korea-ex-china/en/, (Accessed 23 January 2020); First travel-related case of 2019 novel coronavirus detected in United States (2020), https://www.cdc.gov/media/releases/2020/p0121-novel-coronavirus-travel-case.html, (Accessed 15 February 2020); Tsang, K.W., Ho, P.L., Ooi, G.C., A cluster of cases of severe acute respiratory syndrome in Hong Kong (2003) N Engl J Med, 348, pp. 1977-1985; Assiri, A., Al-Tawfq, J.A., Al-Rabeeah, A.A., Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study (2013) Lancet Infect Dis, 13, pp. 752-761; Clinical management of severe acute respiratory infection when novel coronavirus (2019-nCoV) infection is suspected: interim guidance (2020), https://www.who.int/docs/default-source/coronaviruse/clinical-management-of-novel-cov.pdf, (Accessed 15 February 2020); Richman, D.D., Whitley, R.J., Hayden, F.G., (2016) Clinical virology, , 4th edn. ASM Press Washington; Ksiazek, T.G., Erdman, D., Goldsmith, C.S., A novel coronavirus associated with severe acute respiratory syndrome (2003) N Engl J Med, 348, pp. 1953-1966; Kuiken, T., Fouchier, R.A.M., Schutten, M., Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome (2003) Lancet, 362, pp. 263-270; de Groot, R.J., Baker, S.C., Baric, R.S., Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group (2013) J Virol, 87, pp. 7790-7792; Zaki, A.M., van Boheemen, S., Bestebroer, T.M., Osterhaus, A.D., Fouchier, R.A., Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia (2012) N Engl J Med, 367, pp. 1814-1820; Liu, S., Sun, J., Cai, J., Epidemiological, clinical and viral characteristics of fatal cases of human avian influenza A (H7N9) virus in Zhejiang Province, China (2013) J Infect, 67, pp. 595-605; Chen, X., Yang, Z., Lu, Y., Xu, Q., Wang, Q., Chen, L., Clinical features and factors associated with outcomes of patients infected with a novel influenza A (H7N9) virus: a preliminary study (2013) PLoS One, 8; Lee, N., Hui, D., Wu, A., A major outbreak of severe acute respiratory syndrome in Hong Kong (2003) N Engl J Med, 348, pp. 1986-1994; Wang, Q., Zhang, Z., Shi, Y., Jiang, Y., Emerging H7N9 influenza A (novel reassortant avian-origin) pneumonia: radiologic findings (2013) Radiology, 268, pp. 882-889; Müller, N.L., Ooi, G.C., Khong, P.L., Nicolaou, S., Severe acute respiratory syndrome: radiographic and CT findings (2003) AJR Am J Roentgenol, 181, pp. 3-8; Wong, K.T., Antonio, G.E., Hui, D.S., Thin-section CT of severe acute respiratory syndrome: evaluation of 73 patients exposed to or with the disease (2003) Radiology, 228, pp. 395-400; Zhao, Z., Liang, C., Zhang, J., Zhang, R., He, H., Clinical and imaging findings in patients with severe acute respiratory syndrome (2003) Chin Med J (Engl), 116, pp. 1104-1105; Das, K.M., Lee, E.Y., Enani, M.A., CT correlation with outcomes in 15 patients with acute Middle East respiratory syndrome coronavirus (2015) AJR Am J Roentgenol, 204, pp. 736-742; Ajlan, A.M., Ahyad, R.A., Jamjoom, L.G., Alharthy, A., Madani, T.A., Middle East respiratory syndrome coronavirus (MERS-CoV) infection: chest CT findings (2014) AJR Am J Roentgenol, 203, pp. 782-787; Das, K.M., Lee, E.Y., Al Jawder, S.E., Acute Middle East respiratory syndrome coronavirus: temporal lung changes observed on the chest radiographs of 55 patients (2015) AJR Am J Roentgenol, 205, pp. W267-W274; Qureshi, N.R., Hien, T.T., Farrar, J., Gleeson, F.V., The radiologic manifestations of H5N1 avian influenza (2006) J Thorac Imaging, 21, pp. 259-264; Ujita, M., Renzoni, E.A., Veeraraghavan, S., Wells, A.U., Hansell, D.M., Organizing pneumonia: perilobular pattern at thin-section CT (2004) Radiology, 232, pp. 757-761; Travis, W.D., Costabel, U., Hansell, D.M., An official American Thoracic Society/European Respiratory Society statement: update of the international multidisciplinary classification of the idiopathic interstitial pneumonias (2013) Am J Respir Crit Care Med, 188, pp. 733-748","Fan, Y.; Department of Radiology, Wuhan Jinyintan HospitalChina; email: 1024932023@qq.com",,Lancet Publishing Group,14733099,,LIDAB,32105637,English,Lancet Infect. Dis.,Article,Final,Open Access,Scopus,2-s2.0-85082024690,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Rosa G.M., Santos N., Grøndahl-Rosado R., Fonseca F.P., Tavares L., Neto I., Cartaxeiro C., Duarte A.",57215030116;36944684700;57214826604;57214824302;7006528945;55768719600;12785783300;55642497900;,Unveiling patterns of viral pathogen infection in free-ranging carnivores of northern Portugal using a complementary methodological approach,2020,"Comparative Immunology, Microbiology and Infectious Diseases",69,,101432,,,,,10.1016/j.cimid.2020.101432,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079236094&doi=10.1016%2fj.cimid.2020.101432&partnerID=40&md5=608a3b22b823fb7fa150ea7a1a138e2e,"Institute of Zoology, Zoological Society of London, Regent's Park, London, NW1 4RY, United Kingdom; Centre for Ecology, Evolution and Environmental Changes (CE3C), Faculdade de Ciências Universidade de Lisboa, Campo Grande, Lisboa, 1749-016, Portugal; CIBIO/InBIO – Research Network in Biodiversity and Evolutionary Biology, Universidade do Porto, Campus de Vairão, Rua Padre Armando Quintas 7, Vairão, 4485-661, Portugal; Life Sciences Solutions – Thermo Fisher Scientific, P.O. Box 114, Smestad, Oslo, 0309, Norway; CIISA-Centre for Interdisciplinary Research in Animal Health, Faculdade de Medicina Veterinária, Universidade de Lisboa, Avenida da Universidade Tecnica, Lisboa, 1300-477, Portugal","Rosa, G.M., Institute of Zoology, Zoological Society of London, Regent's Park, London, NW1 4RY, United Kingdom, Centre for Ecology, Evolution and Environmental Changes (CE3C), Faculdade de Ciências Universidade de Lisboa, Campo Grande, Lisboa, 1749-016, Portugal; Santos, N., CIBIO/InBIO – Research Network in Biodiversity and Evolutionary Biology, Universidade do Porto, Campus de Vairão, Rua Padre Armando Quintas 7, Vairão, 4485-661, Portugal; Grøndahl-Rosado, R., Life Sciences Solutions – Thermo Fisher Scientific, P.O. Box 114, Smestad, Oslo, 0309, Norway; Fonseca, F.P., Centre for Ecology, Evolution and Environmental Changes (CE3C), Faculdade de Ciências Universidade de Lisboa, Campo Grande, Lisboa, 1749-016, Portugal; Tavares, L., CIISA-Centre for Interdisciplinary Research in Animal Health, Faculdade de Medicina Veterinária, Universidade de Lisboa, Avenida da Universidade Tecnica, Lisboa, 1300-477, Portugal; Neto, I., CIISA-Centre for Interdisciplinary Research in Animal Health, Faculdade de Medicina Veterinária, Universidade de Lisboa, Avenida da Universidade Tecnica, Lisboa, 1300-477, Portugal; Cartaxeiro, C., CIISA-Centre for Interdisciplinary Research in Animal Health, Faculdade de Medicina Veterinária, Universidade de Lisboa, Avenida da Universidade Tecnica, Lisboa, 1300-477, Portugal; Duarte, A., CIISA-Centre for Interdisciplinary Research in Animal Health, Faculdade de Medicina Veterinária, Universidade de Lisboa, Avenida da Universidade Tecnica, Lisboa, 1300-477, Portugal","Pathogen surveillance in free-ranging carnivores presents challenges due to their low densitie and secretive nature. We combined molecular and serological assays to investigate infections by viral pathogens (Canine parvovirus (CPV), Canine distemper virus (CDV) and Canine coronavirus (CCoV)) in Portuguese carnivores (Canis lupus, Vulpes vulpes, Lutra lutra, Martes foina, M. martes, Meles meles, and Genetta genetta) over a period of 16 years. Additionally we explored spatio-temporal patterns of virus occurrence in Canis lupus. Our study identified CPV DNA in all carnivore species with an overall prevalence of 91.9 %. CPV was detected in all sampled years and seasons in Canis lupus, supporting its enzootic nature. CDV RNA was mainly detected in the Canidae family, with viral nucleic acid recorded between 2005 and 2008 with a peak prevalence of 67 % among the wolf population, followed by a sharp decline, suggesting an epizootic behaviour of the virus. Antibodies show that mustelids and viverrids were often exposed to CDV. CCoV was first recorded by molecular methods in wolf samples in 2002, remaining in the wolf populations with marked fluctuations over time. The dual serological and molecular approach provided important epidemiological data on pathogens of wild carnivores in Portugal. These programmes should also include monitoring of other potential reservoir hosts such as domestic cats and dogs. © 2020",Canine distemper virus; Canine parvovirus; Coronavirus; Iberian wild carnivores; Real-time PCR; Serology,antibody; nucleic acid; virus DNA; virus RNA; animal tissue; Article; Canine coronavirus; Canine distemper virus; Canine parvovirus; Canis lupus; carnivore; controlled study; genet (animal); Genetta genetta; Lutra lutra; Martes foina; Martes martes; Meles meles; Mustelidae; nonhuman; Portugal; prevalence; real time polymerase chain reaction; serology; virus infection; Viverridae; Vulpes vulpes; wolf,"Aguirre, A., Wild canids as sentinels of ecological health: a conservation medicine perspective (2009) Parasit. Vectors, 2. , S7–S7; Smith, K.F., Acevedo-Whitehouse, K., Pedersen, A.B., The role of infectious diseases in biological conservation (2009) Anim. Conserv., 12 (1), pp. 1-12; Murray, D.L., Kapke, C.A., Evermann, J.F., Fuller, T.K., Infectious disease and the conservation of free-ranging large carnivores (1999) Anim. Conserv., 2 (4), pp. 241-254; Almberg, E.S., Mech, L.D., Smith, D.W., Sheldon, J.W., Crabtree, R.L., A serological survey of infectious disease in Yellowstone National Park's canid community (2009) PLoS One, 4 (9). , e7042–e7042; Eugster, A.K., Nairn, C., Diarrhea in puppies: parvovirus-like particles demonstrated in their feces (1977) Southwest Vet., 30. , 59–59; Frölich, K., Streich, W.J., Fickel, J., Jung, S., Truyen, U., Hentschke, J., Dedek, J., Latz, N., Epizootiologic investigations of parvovirus infections in free-ranging carnivores from Germany (2005) J. Wildl. Dis., 41 (1), pp. 231-235; Miranda, C., Thompson, G., Canine parvovirus: the worldwide occurrence of antigenic variants (2016) J. Gen. 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Queiroz R. L& M. Santos-Reis Instituto da Conservação da Natureza Lisboa Portugal; Schultz, R.D., Thiel, B., Mukhtar, E., Sharp, P., Larson, L.J., Age and long-term protective immunity in dogs and cats (2010) J. Comp. Pathol., 142, pp. S102-S108; Bronson, E., Emmons, L.H., Murray, S., Dubovi, E.J., Deem, S.L., Serosurvey of pathogens in domestic dogs on the border of Noel Kempff Mercado National Park, Bolivia (2008) J. Zoo Wildl. Med., 39 (1), pp. 28-36; Battilani, M., Bassani, M., Forti, D., Morganti, L., Analysis of the evolution of feline parvovirus (FPV) (2006) Vet. Res. Commun., 30 (1), pp. 223-226; Shackelton, L.A., Parrish, C.R., Truyen, U., Holmes, E.C., High rate of viral evolution associated with the emergence of carnivore parvovirus (2005) Proc. Nat. Acad. Sci. U. S. A., 102 (2), pp. 379-384","Duarte, A.; CIISA-Centre for Interdisciplinary Research in Animal Health, Faculdade de Medicina Veterinária, Universidade de Lisboa, Avenida da Universidade Tecnica, Portugal; email: anaduarte@fmv.ulisboa.pt",,Elsevier Ltd,1479571,,CIMID,32062189,English,Comp. Immunol. Microbiol. Infect. Dis.,Article,Final,,Scopus,2-s2.0-85079236094,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Hellewell J., Abbott S., Gimma A., Bosse N.I., Jarvis C.I., Russell T.W., Munday J.D., Kucharski A.J., Edmunds W.J., Sun F., Flasche S., Quilty B.J., Davies N., Liu Y., Clifford S., Klepac P., Jit M., Diamond C., Gibbs H., van Zandvoort K., Funk S., Eggo R.M., Centre for the Mathematical Modelling of Infectious Diseases COVID-19 Working Group",56899332800;57215686681;57215690500;57215684535;56740337000;57215682390;57204002102;54883807400;7006629172;57215694535;36096719400;57215125608;57215683897;57215550912;51663266700;6603012281;23990626200;57215681790;57215693252;57205317048;26634997200;36113351400;,Feasibility of controlling COVID-19 outbreaks by isolation of cases and contacts,2020,The Lancet Global Health,8,4,,e488,e496,,8,10.1016/S2214-109X(20)30074-7,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081274886&doi=10.1016%2fS2214-109X%2820%2930074-7&partnerID=40&md5=77daac45777015d04462761151368d2f,"Centre for the Mathematical Modelling of Infectious Diseases, Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom","Hellewell, J., Centre for the Mathematical Modelling of Infectious Diseases, Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom; Abbott, S., Centre for the Mathematical Modelling of Infectious Diseases, Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom; Gimma, A., Centre for the Mathematical Modelling of Infectious Diseases, Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom; Bosse, N.I., Centre for the Mathematical Modelling of Infectious Diseases, Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom; Jarvis, C.I., Centre for the Mathematical Modelling of Infectious Diseases, Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom; Russell, T.W., Centre for the Mathematical Modelling of Infectious Diseases, Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom; Munday, J.D., Centre for the Mathematical Modelling of Infectious Diseases, Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom; Kucharski, A.J., Centre for the Mathematical Modelling of Infectious Diseases, Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom; Edmunds, W.J., Centre for the Mathematical Modelling of Infectious Diseases, Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom; Sun, F.; Flasche, S.; Quilty, B.J.; Davies, N.; Liu, Y.; Clifford, S.; Klepac, P.; Jit, M.; Diamond, C.; Gibbs, H.; van Zandvoort, K.; Funk, S., Centre for the Mathematical Modelling of Infectious Diseases, Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom; Eggo, R.M., Centre for the Mathematical Modelling of Infectious Diseases, Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom; Centre for the Mathematical Modelling of Infectious Diseases COVID-19 Working Group","Background: Isolation of cases and contact tracing is used to control outbreaks of infectious diseases, and has been used for coronavirus disease 2019 (COVID-19). Whether this strategy will achieve control depends on characteristics of both the pathogen and the response. Here we use a mathematical model to assess if isolation and contact tracing are able to control onwards transmission from imported cases of COVID-19. Methods: We developed a stochastic transmission model, parameterised to the COVID-19 outbreak. We used the model to quantify the potential effectiveness of contact tracing and isolation of cases at controlling a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-like pathogen. We considered scenarios that varied in the number of initial cases, the basic reproduction number (R0), the delay from symptom onset to isolation, the probability that contacts were traced, the proportion of transmission that occurred before symptom onset, and the proportion of subclinical infections. We assumed isolation prevented all further transmission in the model. Outbreaks were deemed controlled if transmission ended within 12 weeks or before 5000 cases in total. We measured the success of controlling outbreaks using isolation and contact tracing, and quantified the weekly maximum number of cases traced to measure feasibility of public health effort. Findings: Simulated outbreaks starting with five initial cases, an R0 of 1·5, and 0% transmission before symptom onset could be controlled even with low contact tracing probability; however, the probability of controlling an outbreak decreased with the number of initial cases, when R0 was 2·5 or 3·5 and with more transmission before symptom onset. Across different initial numbers of cases, the majority of scenarios with an R0 of 1·5 were controllable with less than 50% of contacts successfully traced. To control the majority of outbreaks, for R0 of 2·5 more than 70% of contacts had to be traced, and for an R0 of 3·5 more than 90% of contacts had to be traced. The delay between symptom onset and isolation had the largest role in determining whether an outbreak was controllable when R0 was 1·5. For R0 values of 2·5 or 3·5, if there were 40 initial cases, contact tracing and isolation were only potentially feasible when less than 1% of transmission occurred before symptom onset. Interpretation: In most scenarios, highly effective contact tracing and case isolation is enough to control a new outbreak of COVID-19 within 3 months. The probability of control decreases with long delays from symptom onset to isolation, fewer cases ascertained by contact tracing, and increasing transmission before symptoms. This model can be modified to reflect updated transmission characteristics and more specific definitions of outbreak control to assess the potential success of local response efforts. Funding: Wellcome Trust, Global Challenges Research Fund, and Health Data Research UK. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license",,"Article; basic reproduction number; binomial distribution; contact examination; disease transmission; dispersity; epidemic; feasibility study; human; infection control; nonhuman; novel coronavirus 2019; novel coronavirus disease 2019; priority journal; SARS coronavirus; sensitivity analysis; severe acute respiratory syndrome; social isolation; stochastic model; survival rate; Betacoronavirus; contact examination; Coronavirinae; Coronavirus infection; epidemic; feasibility study; pathogenicity; patient isolation; virus pneumonia; Betacoronavirus; Contact Tracing; Coronavirus; Coronavirus Infections; Disease Outbreaks; Feasibility Studies; Humans; Patient Isolation; Pneumonia, Viral","Novel coronavirus (2019-nCoV) situation report 16 (2020), https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200205-sitrep-16-ncov.pdf?sfvrsn=23af287f_2, World Health Organization (Accessed 5 February 2020); Novel coronavirus (2019-nCoV) situation report 2 (2020), https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200122-sitrep-2-2019-ncov.pdf?sfvrsn=4d5bcbca_2, World Health Organization (Accessed 22 January 2020); Public health management of persons having had contact with novel coronavirus cases in the European Union (2020), https://www.ecdc.europa.eu/en/publications-data/public-health-management-persons-having-had-contact-novel-coronavirus-cases, European Centre for Disease Prevention and Control (Accessed 2 February 2020); Quilty, B., Clifford, S., Flasche, S., Eggo, R.M., Effectiveness of airport screening at detecting travellers infected with 2019-nCoV (2020), https://cmmid.github.io/ncov/airport_screening_report/airport_screening_preprint_2020_01_30.pdf, (Accessed 5 February 2020); Fraser, C., Riley, S., Anderson, R.M., Ferguson, N.M., Factors that make an infectious disease outbreak controllable (2004) Proc Natl Acad Sci USA, 101, pp. 6146-6151; Peak, C.M., Childs, L.M., Grad, Y.H., Buckee, C.O., Comparing nonpharmaceutical interventions for containing emerging epidemics (2017) Proc Natl Acad Sci USA, 114, pp. 4023-4028; Glasser, J.W., Hupert, N., McCauley, M.M., Hatchett, R., Modeling and public health emergency responses: lessons from SARS (2011) Epidemics, 3, pp. 32-37; Swanson, K.C., Altare, C., Wesseh, C.S., Contact tracing performance during the Ebola epidemic in Liberia, 2014–2015 (2018) PLoS Negl Trop Dis, 12; Implementation and management of contact tracing for Ebola virus disease (2015), http://www.who.int/csr/resources/publications/ebola/contact-tracing/en/, World Health Organization (Accessed 4 February 2020); Kang, M., Song, T., Zhong, H., Contact tracing for imported case of Middle East respiratory syndrome, China, 2015 (2016) Emerging Infect Dis, 22, p. 9; MERS-CoV close contact algorithm. 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(preprint); Coronavirus patient is University of York student (2020), https://www.bbc.com/news/health-51337400, (Accessed 19 February 2020); Riou, J., Althaus, C.L., Pattern of early human-to-human transmission of Wuhan 2019 novel coronavirus (2019-nCoV), December 2019 to January 2020 (2020) Eurosurveillance, 25; Bedford, T., Neher, R., Hadfield, J., Hodcroft, E., Ilcisin, M., Müller, N., Genomic analysis of nCoV spread. Situation report 2020-01-30 (2020), https://nextstrain.org/narratives/ncov/sit-rep/2020-01-30, (Accessed 30 January 2020); Majumder, M., Mandl, K.D., Early transmissibility assessment of a novel coronavirus in Wuhan, China (2020), https://papers.ssrn.com/abstract=3524675, Social Science Research Network Rochester, NY (Accessed 30 January 2020); Read, J.M., Bridgen, J.R., Cummings, D.A., Ho, A., Jewell, C.P., Novel coronavirus 2019-nCoV: early estimation of epidemiological parameters and epidemic predictions (2020) medRxiv, , published online Jan 28. (preprint); Zhao, S., Ran, J., Musa, S.S., Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: a data-driven analysis in the early phase of the outbreak (2020) Int J Infect Dis, 92, pp. 214-217; Dugas, A.F., Jalalpour, M., Gel, Y., Influenza forecasting with Google Flu Trends (2013) PLoS One, 8; Yu, P., Zhu, J., Zhang, Z., Han, Y., Huang, L., A familial cluster of infection associated with the 2019 novel coronavirus indicating potential person-to-person transmission during the incubation period (2020) J Infect Dis, , published online Feb 18; Heymann, D.L., Shindo, N., COVID-19: what is next for public health? (2020) Lancet, 395, pp. 542-545; Dhillon, R.S., Srikrishna, D., When is contact tracing not enough to stop an outbreak? (2018) Lancet Infect Dis, 18, pp. 1302-1304; Olu, O.O., Lamunu, M., Nanyunja, M., Contact tracing during an outbreak of Ebola virus disease in the Western area districts of Sierra Leone: lessons for future Ebola outbreak response (2016) Front Public Health, 4, p. 130; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506; Pang, X., Zhu, Z., Xu, F., Evaluation of control measures implemented in the severe acute respiratory syndrome outbreak in Beijing, 2003 (2003) JAMA, 290, pp. 3215-3221","Eggo, R.M.; Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical MedicineUnited Kingdom; email: r.eggo@lshtm.ac.uk",,Elsevier Ltd,2214109X,,,32119825,English,Lancet Global Health,Article,Final,Open Access,Scopus,2-s2.0-85081274886,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Gunasekaran M., Bansal S., Ravichandran R., Sharma M., Perincheri S., Rodriguez F., Hachem R., Fisher C.E., Limaye A.P., Omar A., Smith M.A., Bremner R.M., Mohanakumar T.",53881302200;57192951604;57202467475;57135877300;6505616414;57214817842;7003769216;55860468800;7004568268;57189236239;57120370700;24549094900;7101666914;,Respiratory viral infection in lung transplantation induces exosomes that trigger chronic rejection,2020,Journal of Heart and Lung Transplantation,39,4,,379,388,,,10.1016/j.healun.2019.12.009,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078834003&doi=10.1016%2fj.healun.2019.12.009&partnerID=40&md5=2bec7755dd602bf75048b19b0cbb1814,"St. Joseph's Hospital and Medical Center, Norton Thoracic Institute, Phoenix, AZ, United States; Department of Pathology, Yale School of Medicine, New Haven, CT, United States; Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States; Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA, United States","Gunasekaran, M., St. Joseph's Hospital and Medical Center, Norton Thoracic Institute, Phoenix, AZ, United States; Bansal, S., St. Joseph's Hospital and Medical Center, Norton Thoracic Institute, Phoenix, AZ, United States; Ravichandran, R., St. Joseph's Hospital and Medical Center, Norton Thoracic Institute, Phoenix, AZ, United States; Sharma, M., St. Joseph's Hospital and Medical Center, Norton Thoracic Institute, Phoenix, AZ, United States; Perincheri, S., Department of Pathology, Yale School of Medicine, New Haven, CT, United States; Rodriguez, F., St. Joseph's Hospital and Medical Center, Norton Thoracic Institute, Phoenix, AZ, United States; Hachem, R., Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States; Fisher, C.E., Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA, United States; Limaye, A.P., Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA, United States; Omar, A., St. Joseph's Hospital and Medical Center, Norton Thoracic Institute, Phoenix, AZ, United States; Smith, M.A., St. Joseph's Hospital and Medical Center, Norton Thoracic Institute, Phoenix, AZ, United States; Bremner, R.M., St. Joseph's Hospital and Medical Center, Norton Thoracic Institute, Phoenix, AZ, United States; Mohanakumar, T., St. Joseph's Hospital and Medical Center, Norton Thoracic Institute, Phoenix, AZ, United States","BACKGROUND: Respiratory viral infections can increase the risk of chronic lung allograft dysfunction after lung transplantation, but the mechanisms are unknown. In this study, we determined whether symptomatic respiratory viral infections after lung transplantation induce circulating exosomes that contain lung-associated self-antigens and assessed whether these exosomes activate immune responses to self-antigens. METHODS: Serum samples were collected from lung transplant recipients with symptomatic lower- and upper-tract respiratory viral infections and from non-symptomatic stable recipients. Exosomes were isolated via ultracentrifugation; purity was determined using sucrose cushion; and presence of lung self-antigens, 20S proteasome, and viral antigens for rhinovirus, coronavirus, and respiratory syncytial virus were determined using immunoblot. Mice were immunized with circulating exosomes from each group and resulting differential immune responses and lung histology were analyzed. RESULTS: Exosomes containing self-antigens, 20S proteasome, and viral antigens were detected at significantly higher levels (p < 0.05) in serum of recipients with symptomatic respiratory viral infections (n = 35) as compared with stable controls (n = 32). Mice immunized with exosomes from recipients with respiratory viral infections developed immune responses to self-antigens, fibrosis, small airway occlusion, and significant cellular infiltration; mice immunized with exosomes from controls did not (p < 0.05). CONCLUSIONS: Circulating exosomes isolated from lung transplant recipients diagnosed with respiratory viral infections contained lung self-antigens, viral antigens, and 20S proteasome and elicited immune responses to lung self-antigens that resulted in development of chronic lung allograft dysfunction in immunized mice. © 2020 International Society for Heart and Lung Transplantation",antibodies; antigens; chronic rejection; exosomes; graft rejection; lung transplantation; respiratory viral infection,antigen; proteasome; self antigen; unclassified drug; virus antigen; adult; Article; chronic graft rejection; controlled study; exosome; female; human; lung graft rejection; lung transplantation; major clinical study; male; priority journal; viral respiratory tract infection,"Arcasoy, S.M., Kotloff, R.M., Lung transplantation (1999) N Engl J Med, 340, pp. 1081-1091; Glanville, A.R., Bronchoscopic monitoring after lung transplantation (2010) Semin Respir Crit Care Med, 31, pp. 208-221; Sato, M., Waddell, T.K., Wagnetz, U., Restrictive allograft syndrome (RAS): a novel form of chronic lung allograft dysfunction (2011) J Heart Lung Transplant, 30, pp. 735-742; Witt, C.A., Gaut, J.P., Yusen, R.D., Acute antibody-mediated rejection after lung transplantation (2013) J Heart Lung Transplant, 32, pp. 1034-1040; Stewart, S., Fishbein, M.C., Snell, G.I., Revision of the 1996 working formulation for the standardization of nomenclature in the diagnosis of lung rejection (2007) J Heart Lung Transplant, 26, pp. 1229-1242; Arcasoy, S.M., Berry, G., Marboe, C.C., Pathologic interpretation of transbronchial biopsy for acute rejection of lung allograft is highly variable (2011) Am J Transplant, 11, pp. 320-328; Almaghrabi, R.S., Omrani, A.S., Memish, Z.A., Cytomegalovirus infection in lung transplant recipients (2017) Expert Rev Respir Med, 11, pp. 377-383; Chalermskulrat, W., Neuringer, I.P., Schmitz, J.L., Human leukocyte antigen mismatches predispose to the severity of bronchiolitis obliterans syndrome after lung transplantation (2003) Chest, 123, pp. 1825-1831; Saini, D., Weber, J., Ramachandran, S., Alloimmunity-induced autoimmunity as a potential mechanism in the pathogenesis of chronic rejection of human lung allografts (2011) J Heart Lung Transplant, 30, pp. 624-631; Bharat, A., Saini, D., Steward, N., Antibodies to self-antigens predispose to primary lung allograft dysfunction and chronic rejection (2010) Ann Thorac Surg, 90, pp. 1094-1101; Goers, T.A., Ramachandran, S., Aloush, A., Trulock, E., Patterson, G.A., Mohanakumar, T., De novo production of K-alpha1 tubulin-specific antibodies: role in chronic lung allograft rejection (2008) J Immunol, 180, pp. 4487-4494; Hachem, R.R., Tiriveedhi, V., Patterson, G.A., Aloush, A., Trulock, E.P., Mohanakumar, T., Antibodies to K-alpha 1 tubulin and collagen V are associated with chronic rejection after lung transplantation (2012) Am J Transplant, 12, pp. 2164-2171; Daud, S.A., Yusen, R.D., Meyers, B.F., Impact of immediate primary lung allograft dysfunction on bronchiolitis obliterans syndrome (2007) Am J Respir Crit Care Med, 175, pp. 507-513; Bharat, A., Kuo, E., Saini, D., Respiratory virus-induced dysregulation of T-regulatory cells leads to chronic rejection (2010) Ann Thorac Surg, 90, pp. 1637-1644. , discussion 44; Billings, J.L., Hertz, M.I., Savik, K., Wendt, C.H., Respiratory viruses and chronic rejection in lung transplant recipients (2002) J Heart Lung Transplant, 21, pp. 559-566; Fisher, C.E., Mohanakumar, T., Limaye, A.P., Respiratory virus infections and chronic lung allograft dysfunction: assessment of virology determinants (2016) J Heart Lung Transplant, 35, pp. 946-947; Fisher, C.E., Preiksaitis, C.M., Lease, E.D., Symptomatic respiratory virus infection and chronic lung allograft dysfunction (2016) Clin Infect Dis, 62, pp. 313-319; Khalifah, A.P., Hachem, R.R., Chakinala, M.M., Respiratory viral infections are a distinct risk for bronchiolitis obliterans syndrome and death (2004) Am J Respir Crit Care Med, 170, pp. 181-187; Magnusson, J., Westin, J., Andersson, L.M., Brittain-Long, R., Riise, G.C., The impact of viral respiratory tract infections on long-term morbidity and mortality following lung transplantation: a retrospective cohort study using a multiplex PCR panel (2013) Transplantation, 95, pp. 383-388; Bridges, N.D., Spray, T.L., Collins, M.H., Bowles, N.E., Towbin, J.A., Adenovirus infection in the lung results in graft failure after lung transplantation (1998) J Thorac Cardiovasc Surg, 116, pp. 617-623; Gunasekaran, M., Xu, Z., Nayak, D.K., Donor-derived exosomes With lung self-antigens in human lung allograft rejection (2017) Am J Transplant, 17, pp. 474-484; Dieudé, M., Bell, C., Turgeon, J., The 20S proteasome core, active within apoptotic exosome-like vesicles, induces autoantibody production and accelerates rejection (2015) Sci Transl Med, 7, p. 318ra200; Verleden, G.M., Raghu, G., Meyer, K.C., Glanville, A.R., Corris, P., A new classification system for chronic lung allograft dysfunction (2014) J Heart Lung Transplant, 33, pp. 127-133; Gunasekaran, M., Sharma, M., Hachem, R., Bremner, R., Smith, M.A., Mohanakumar, T., Circulating exosomes with distinct properties during chronic lung allograft rejection (2018) J Immunol, 200, pp. 2535-2541; Sharma, M., Liu, W., Perincheri, S., Gunasekaran, M., Mohanakumar, T., Exosomes expressing the self-antigens myosin and vimentin play an important role in syngeneic cardiac transplant rejection induced by antibodies to cardiac myosin (2018) Am J Transplant, 18, pp. 1626-1635; Théry, C., Amigorena, S., Raposo, G., Clayton, A., Isolation and characterization of exosomes from cell culture supernatants and biological fluids (2006) Curr Protoc Cell Biol, 30, pp. 3.22.1-3.22.29; Subramanian, V., Ramachandran, S., Banan, B., Immune response to tissue-restricted self-antigens induces airway inflammation and fibrosis following murine lung transplantation (2014) Am J Transplant, 14, pp. 2359-2366; Fukami, N., Ramachandran, S., Saini, D., Antibodies to MHC class I induce autoimmunity: role in the pathogenesis of chronic rejection (2009) J Immunol, 182, pp. 309-318; Tiriveedhi, V., Gautam, B., Sarma, N.J., Pre-transplant antibodies to Kalpha1 tubulin and collagen-V in lung transplantation: clinical correlations (2013) J Heart Lung Transplant, 32, pp. 807-814; Walker, J.D., Maier, C.L., Pober, J.S., Cytomegalovirus-infected human endothelial cells can stimulate allogeneic CD4+ memory T cells by releasing antigenic exosomes (2009) J Immunol, 182, pp. 1548-1559; Ceccarelli, S., Visco, V., Raffa, S., Wakisaka, N., Pagano, J.S., Torrisi, M.R., Epstein-Barr virus latent membrane protein 1 promotes concentration in multivesicular bodies of fibroblast growth factor 2 and its release through exosomes (2007) Int J Cancer, 121, pp. 1494-1506; Vallhov, H., Gutzeit, C., Johansson, S.M., Exosomes containing glycoprotein 350 released by EBV-transformed B cells selectively target B cells through CD21 and block EBV infection in vitro (2011) J Immunol, 186, pp. 73-82; Fleming, A., Sampey, G., Chung, M.C., The carrying pigeons of the cell: exosomes and their role in infectious diseases caused by human pathogens (2014) Pathog Dis, 71, pp. 109-120; Yao, Z., Qiao, Y., Li, X., Exosomes exploit the virus entry machinery and pathway to transmit IFN-alpha-induced antiviral activity (2018) J Virol, 92. , e01578-18","Mohanakumar, T.; St. Joseph's Hospital and Medical Center, Norton Thoracic Institute, Suite 105, 124 West Thomas Road, United States; email: tm.kumar@dignityhealth.org",,Elsevier USA,10532498,,JHLTE,32033844,English,J. Heart Lung Transplant.,Article,Final,,Scopus,2-s2.0-85078834003,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Day M.J., Carey S., Clercx C., Kohn B., MarsilIo F., Thiry E., Freyburger L., Schulz B., Walker D.J.",24166167900;36854747900;7004451560;26643234800;55788078800;7004309145;13410884300;9250187800;7404440335;,Aetiology of Canine Infectious Respiratory Disease Complex and Prevalence of its Pathogens in Europe,2020,Journal of Comparative Pathology,176,,,86,108,,,10.1016/j.jcpa.2020.02.005,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081674734&doi=10.1016%2fj.jcpa.2020.02.005&partnerID=40&md5=9562eec4631d5ad73bd98c3c38d79463,"School of Veterinary and Life Sciences, Murdoch University, Murdoch, Western Australia and Bristol Veterinary School, University of Bristol, Langford, United Kingdom; College of Veterinary Medicine, Michigan State University, United States; Faculty of Veterinary Medicine, Liège University, Liège, Belgium; Faculty of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany; Faculty of Veterinary Medicine, University of Teramo, Teramo, Italy; Université de Lyon, VetAgro Sup, Agressions Pulmonaires et Circulatoires dans le Sepsis, Marcy l'Etoile and La Compagnie des Animaux, SantéVet, Lyon, France; Ludwig-Maximillian-University of Munich, Munich, Germany; Anderson Moores Veterinary Specialists, Winchester, Hampshire, United Kingdom","Day, M.J., School of Veterinary and Life Sciences, Murdoch University, Murdoch, Western Australia and Bristol Veterinary School, University of Bristol, Langford, United Kingdom; Carey, S., College of Veterinary Medicine, Michigan State University, United States; Clercx, C., Faculty of Veterinary Medicine, Liège University, Liège, Belgium; Kohn, B., Faculty of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany; MarsilIo, F., Faculty of Veterinary Medicine, University of Teramo, Teramo, Italy; Thiry, E., Faculty of Veterinary Medicine, Liège University, Liège, Belgium; Freyburger, L., Université de Lyon, VetAgro Sup, Agressions Pulmonaires et Circulatoires dans le Sepsis, Marcy l'Etoile and La Compagnie des Animaux, SantéVet, Lyon, France; Schulz, B., Ludwig-Maximillian-University of Munich, Munich, Germany; Walker, D.J., Anderson Moores Veterinary Specialists, Winchester, Hampshire, United Kingdom","The canine infectious respiratory disease complex (CIRDC) is an endemic worldwide syndrome involving multiple viral and bacterial pathogens. Traditionally, Bordetella bronchiseptica (Bb), canine adenovirus type 2 (CAV-2), canine distemper virus (CDV), canine herpesvirus (CHV) and canine parainfluenza virus (CPiV) were considered the major causative agents. Lately, new pathogens have been implicated in the development of CIRDC, namely canine influenza virus (CIV), canine respiratory coronavirus (CRCoV), canine pneumovirus (CnPnV), Mycoplasma cynos and Streptococcus equi subspecies zooepidemicus. To better understand the role of the different pathogens in the development of CIRDC and their epidemiological relevance in Europe, prevalence data were collected from peer-reviewed publications and summarized. Evidence of exposure to Bb is frequently found in healthy and diseased dogs and client-owned dogs are as likely to be infected as kennelled dogs. Co-infections with viral pathogens are common. The findings confirm that Bb is an important cause of CIRDC in Europe. CAV-2 and CDV recovery rates from healthy and diseased dogs are low and the most likely explanation for this is control through vaccination. Seroconversion to CHV can be demonstrated following CIRDC outbreaks and CHV has been detected in the lower respiratory tract of diseased dogs. There is some evidence that CHV is not a primary cause of CIRDC, but opportunistically re-activates at the time of infection and exacerbates the disease. The currently available data suggest that CIV is, at present, neither a prevalent nor a significant pathogen in Europe. CPiV remains an important pathogen in CIRDC and facilitates co-infection with other viral and bacterial pathogens. CnPnV and CRCoV are important new elements in the aetiology of CIRDC and spread particularly well in multi-dog establishments. M. cynos is common in Europe and is more likely to occur in younger and kennelled dogs. This organism is frequently found together with other CIRDC pathogens and is significantly associated with more severe respiratory signs. S. zooepidemicus infection is not common and appears to be a particular problem in kennels. Protective immunity against respiratory diseases is rarely complete, and generally only a reduction in clinical signs and excretion of pathogen can be achieved through vaccination. However, even vaccines that only reduce and do not prevent infection carry epidemiological advantages. They reduce spread, increase herd immunity and decrease usage of antimicrobials. Recommending vaccination of dogs against pathogens of CIRDC will directly provide epidemiological advantages to the population and the individual dog. © 2020 The Authors",canine infectious respiratory disease complex; dog; pathogen; vaccination,adenovirus infection; bacterial virulence; Bordetella bronchiseptica; Canid herpesvirus 1; Canine adenovirus 2; Canine coronavirus; Canine distemper virus; disease exacerbation; disease severity; epidemiological data; evidence based practice; herd immunity; human; infection control; infectious respiratory disease complex; Influenza virus; mixed infection; Mycoplasma; nonhuman; Paramyxovirinae; Pneumovirus; prevalence; priority journal; Review; Streptococcus; vaccination; virus pathogenesis; virus virulence,"Adams, V.J., Evans, K.M., Sampson, J., Wood, J.L., Methods and mortality results of a health survey of purebred dogs in the UK (2010) Journal of Small Animal Practice, 51, pp. 512-524; Appel, M.J., Binn, L.N., Canine parainfluenza virus (1987) Viral Infections of Carnivores, pp. 125-132. , M.J. 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Zeugswetter, F., Weissenböck, H., Shibly, S., Hassan, J., Spergser, J., Lethal bronchopneumonia caused by Mycoplasma cynos in a litter of golden retriever puppies (2007) Veterinary Record, 161, pp. 626-627","Day, M.J.; School of Veterinary and Life Sciences, Murdoch University, Murdoch, Western Australia and Bristol Veterinary School, University of BristolUnited Kingdom; email: profmjday@gmail.com",,W.B. Saunders Ltd,219975,,JCVPA,,English,J. Comp. Pathol.,Review,Final,Open Access,Scopus,2-s2.0-85081674734,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Sharma B.K., Kakker N.K., Bhadouriya S., Chhabra R.",7403255796;6602206587;57201394456;56168473300;,Effect of TLR agonist on infections bronchitis virus replication and cytokine expression in embryonated chicken eggs,2020,Molecular Immunology,120,,,52,60,,,10.1016/j.molimm.2020.02.001,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079392185&doi=10.1016%2fj.molimm.2020.02.001&partnerID=40&md5=fcb571ee96cc5dd55244ebdcfdb8295f,"Department of Animal HusbandryMadhya Pradesh, India; Principal Scientist and Head, Department of Veterinary Microbiology, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana 125 004, India; College Central Laboratory, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana 125 004, India","Sharma, B.K., Department of Animal HusbandryMadhya Pradesh, India; Kakker, N.K., Principal Scientist and Head, Department of Veterinary Microbiology, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana 125 004, India; Bhadouriya, S., Department of Animal HusbandryMadhya Pradesh, India; Chhabra, R., College Central Laboratory, Lala Lajpat Rai University of Veterinary and Animal Sciences, Hisar, Haryana 125 004, India","Avian infectious bronchitis (IB) is an acute, highly infectious and contagious viral disease of chickens caused by avian infectious bronchitis virus (IBV) belonging to the genus Coronavirus and family Coronaviridae. It can affect all age groups of birds. The toll-like receptors (TLRs) are a major class of innate immune pattern recognition receptors that have a key role in immune response and defense against various infections.The TLRs are essential for initiation of innate immune responses and in the development of adaptive immune responses. An in ovo model was employed to study the antiviral activity of TLR ligands (Pam3CSK4, LPS and CpG ODN) on replication of IBV. It was hypothesized that optimum dose and specific timing of TLR ligands may reduce viral load of IBV in specific pathogen free (SPF) embryonated chicken eggs (ECEs). Further, the mechanism involved in the TLR-mediated antiviral response in chorioallantoic membrane (CAM) of ECEs was investigated. The ECEs of 9–11 days old were treated with different doses (high, intermediate and low) of TLR-2 (Pam3CSK4), TLR-4 (LPS) and TLR-21 (CpG ODN) ligands. In addition, to know the timing of TLR ligand treatment, six time intervals were analyzed viz. 36, 24 and 12 h prior to infection, time of infection (co-administration of TLR ligands and avian IBV) and 12 and 24 h post-IBV infection. For studying the relative expression of immuno-stimulatory genes (IFN-α, IFN-β, IFN-γ, IL-1β, iNOS and OAS) in CAM, TLR ligands were administered through intra-allantoicroute and CAM were collected at 4, 8 and 16 h post treatment. The results demonstrated that intermediate dose of all the three TLR ligands significantly reduced virus titers and used in the present study. However, the LPS reduced virus titer pre- and post-IBV infection but Pam3CSK4 and CpG ODN reduced only pre-IBV infection. Further analysis showed that TLR ligands induced IFN-γ, IL-1β and IFN stimulated genes viz. iNOS and OAS genes in CAM. The present study pointed towards the novel opportunities for rational design of LPS as immuno-stimulatory agent in chickens with reference to IBV. It may be speculated that in ovo administration of these TLR ligands may enhance resistance against viral infection in neonatal chicken and may contribute towards the development of more effective and safer vaccines including in ovo vaccines. © 2020 Elsevier Ltd",Cytokine expression; Embryonated chicken eggs; IBV replication; Infectious bronchitis virus; TLR ligands,beta interferon; complementary DNA; CpG oligodeoxynucleotide; cytokine; gamma interferon; inducible nitric oxide synthase; interleukin 1beta; lipopolysaccharide; messenger RNA; pam 3csk 4; toll like receptor 2; toll like receptor 4; toll like receptor 9; toll like receptor agonist; unclassified drug; adaptive immunity; animal experiment; animal tissue; antiviral activity; Article; avian infectious bronchitis; Avian infectious bronchitis virus; controlled study; cytokine response; DNA synthesis; drug dose comparison; embryo; innate immunity; nonhuman; priority journal; protein expression; virus load; virus replication,"Abdul-Careem, M.F., Hunter, B.D., Parvizi, P., Haghighi, H.R., Thanthrige-Don, N., Sharif, S., Cytokine gene expression patterns associated with immunization against Marek's disease in chickens (2007) Vaccine, 25 (3), pp. 424-432; Akira, S., Takeda, K., Toll-like receptor signalling (2004) Nat. 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Snedecor and William G. Cochran (No. QA276. 12. S6313 1989.) (1989); Song, K.D., Lillehoj, H.S., Choi, K.D., Zarlenga, D., Han, J.Y., Expression and functional characterization of recombinant chicken interferon-gamma (1997) Vet. Immunol.Immunopathol., 58 (3-4), pp. 321-333; Thoelen, S., De Clercq, N., Tornieporth, N., A prophylactic hepatitis B vaccine with a novel adjuvant system (2001) Vaccine, 19 (17-19), pp. 2400-2403; Villanueva, A.I., Kulkarni, R.R., Sharif, S., Synthetic double-stranded RNA oligonucleotides are immunostimulatory for chicken spleen cells (2011) Dev. Comp. Immunol., 35 (1), pp. 28-34; Wang, X., Rosa, A.J., Oliverira, H.N., Rosa, G.J., Guo, X., Travnicek, M., Girshick, T., Transcriptome of local innate and adaptive immunity during early phase of infectious bronchitis viral infection (2006) Viral Immunol., 19 (4), pp. 768-774; Wang, Y., Shan, C., Ming, S., Liu, Y., Du, Y., Jiang, G., Immunoadjuvant effects of bacterial genomic DNA and CpGoligodeoxynucleotides on avian influenza virus subtype H5N1 inactivated oil emulsion vaccine in chicken (2009) Res. Vet. Sci., 86 (3), pp. 399-405; Weining, K.C., Schultz, U., Münster, U., Kaspers, B., Staeheli, P., Biological properties of recombinant chicken interferon‐γ (1996) Eur. J. Immunol., 26 (10), pp. 2440-2447; Zhu, Y., Meng, W., Li, X., Gao, H., Hanagata, N., Design of mesoporous silica/cytosine− phosphodiester− guanine oligodeoxynucleotide complexes to enhance delivery efficiency (2010) J. Phys. Chem. C., 115 (2), pp. 447-452","Chhabra, R.; College Central Laboratory, Lala Lajpat Rai University of Veterinary and Animal SciencesIndia; email: rchhabra59@rediffmail.com",,Elsevier Ltd,1615890,,IMCHA,32065987,English,Mol. Immunol.,Article,Final,,Scopus,2-s2.0-85079392185,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Specialized Committee Of Neurogenetics Neurophysician Branch Of Chinese Medical Doctor Association, Jiang H., Tang B.",57216087188;57216086817;55534015200;,Expert consensus on the management strategy of patients with hereditary ataxia during prevention and control of novel coronavirus pneumonia epidemic,2020,Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics,37,4,,359,366,,,10.3760/cma.j.issn.1003-9406.2020.04.001,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082561881&doi=10.3760%2fcma.j.issn.1003-9406.2020.04.001&partnerID=40&md5=c2dd70da3ef7fe8e7a2c061b485b2193,"Department of Neurology, Hunan Provincial Key Laboratory for Neurodegenerative Disorders, National Clinical Medical Research Center for Geriatric Diseases, Xiangya Hospital, Central South University, Changsha, Hunan 410083, China","Specialized Committee Of Neurogenetics Neurophysician Branch Of Chinese Medical Doctor Association, Department of Neurology, Hunan Provincial Key Laboratory for Neurodegenerative Disorders, National Clinical Medical Research Center for Geriatric Diseases, Xiangya Hospital, Central South University, Changsha, Hunan 410083, China; Jiang, H.; Tang, B.","Since December 2019, a series of highly infectious cases of unexplained pneumonia have been discovered in Wuhan, Hubei Province, which have been confirmed as '2019 corona virus disease' caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 virus can invade many human systems including the lungs. Patients with central nervous system involvement may show a series of neurological symptoms, which is easy to be misdiagnosed and neglected, thereby increasing the risk of SARS-CoV-2 transmission. Hereditary ataxia is a large group of neurodegenerative diseases with great clinical and genetic heterogeneity and high mortality and disability. In view of the seriousness of the COVID-19 epidemic, a series of prevention and control measures adopted by the government have restricted the follow-up, diagnosis and treatment of patients by the hospitals, which has a great impact on their mental and physical health. In order to standardize the management of patients during the prevention and control of COVID-19 epidemic, the Specialized Committee of Neurogenetics of the Neurophysician Branch of Chinese Medical Doctor Association has formulated this consensus, with an aim to help patients to overcome the difficulties and pass the epidemic prevention period safely.",,,,,,NLM (Medline),10039406,,,32219814,Chinese,Zhonghua Yi Xue Yi Chuan Xue Za Zhi,Article,Final,,Scopus,2-s2.0-85082561881,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Chen Y., Guo Y., Pan Y., Zhao Z.J.",57214994098;57215001423;35278648800;23036954500;,Structure analysis of the receptor binding of 2019-nCoV,2020,Biochemical and Biophysical Research Communications,525,1,,135,140,,2,10.1016/j.bbrc.2020.02.071,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079618683&doi=10.1016%2fj.bbrc.2020.02.071&partnerID=40&md5=89b2527b7be75e401795bb213de4e38a,"Edmond H. Fischer Translational Medical Research Laboratory, Precision Medicine Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong 518107, China; Department of Pathology, University of Oklahoma Health Sciences Center, 940 Stanton L. Young Blvd, Oklahoma City, OK 73104, United States","Chen, Y., Edmond H. Fischer Translational Medical Research Laboratory, Precision Medicine Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong 518107, China; Guo, Y., Edmond H. Fischer Translational Medical Research Laboratory, Precision Medicine Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong 518107, China; Pan, Y., Edmond H. Fischer Translational Medical Research Laboratory, Precision Medicine Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong 518107, China; Zhao, Z.J., Edmond H. Fischer Translational Medical Research Laboratory, Precision Medicine Center, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong 518107, China, Department of Pathology, University of Oklahoma Health Sciences Center, 940 Stanton L. Young Blvd, Oklahoma City, OK 73104, United States","2019-nCoV is a newly identified coronavirus with high similarity to SARS-CoV. We performed a structural analysis of the receptor binding domain (RBD) of spike glycoprotein responsible for entry of coronaviruses into host cells. The RBDs from the two viruses share 72% identity in amino acid sequences, and molecular simulation reveals highly similar ternary structures. However, 2019-nCoV has a distinct loop with flexible glycyl residues replacing rigid prolyl residues in SARS-CoV. Molecular modeling revealed that 2019-nCoV RBD has a stronger interaction with angiotensin converting enzyme 2 (ACE2). A unique phenylalanine F486 in the flexible loop likely plays a major role because its penetration into a deep hydrophobic pocket in ACE2. ACE2 is widely expressed with conserved primary structures throughout the animal kingdom from fish, amphibians, reptiles, birds, to mammals. Structural analysis suggests that ACE2 from these animals can potentially bind RBD of 2019-nCoV, making them all possible natural hosts for the virus. 2019-nCoV is thought to be transmitted through respiratory droplets. However, since ACE2 is predominantly expressed in intestines, testis, and kidney, fecal-oral and other routes of transmission are also possible. Finally, antibodies and small molecular inhibitors that can block the interaction of ACE2 with RBD should be developed to combat the virus. © 2020 The Authors",Coronavirus; Molecular modeling; Sequence analysis; Structure analysis,angiotensin converting enzyme 2; coronavirus spike glycoprotein; glycine; phenylalanine; proline; amino acid sequence; Article; Betacoronavirus; binding site; human; human tissue; hydrophobicity; molecular interaction; molecular model; nonhuman; nucleotide sequence; priority journal; protein domain; protein expression; receptor binding; receptor binding domain; Severe acute respiratory syndrome coronavirus 2; structure analysis; virus cell interaction; virus transmission,"Wang, C., Horby, P.W., Hayden, F.G., Gao, G.F., A novel coronavirus outbreak of global health concern (2020) Lancet, , https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30185-9/fulltext, Epub ahead of print; Fehr, A.R., Perlman, S., Coronaviruses: an overview of their replication and pathogenesis (2015) Methods Mol. Biol., 1282, pp. 1-23. , https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369385/; Li, F., Structure, function, and evolution of coronavirus spike proteins (2016) Annu Rev Virol, 3, pp. 237-261. , https://www.annualreviews.org/doi/abs/10.1146/annurev-virology-110615-042301?rfr_dat=cr_pub%3Dpubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&journalCode=virology; Li, W., Moore, M.J., Vasilieva, N., Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus (2003) Nature, 426, pp. 450-454. , https://www.nature.com/articles/nature02145; Xiao, X., Chakraborti, S., Dimitrov, A.S., The SARS-CoV S glycoprotein: expression and functional characterization (2013) Biochem. Biophys. Res. Commun., 312, pp. 1159-1164. , https://www.sciencedirect.com/science/article/abs/pii/S0006291X03024136?via%3Dihub; Li, F., Li W, W., Farzan, M., Harrison, S.C., Structure of SARS coronavirus spike receptor-binding domain complexed with receptor (2005) Science, 309, pp. 1864-1868. , https://science.sciencemag.org/content/309/5742/1864.full; Keidar, S., Kaplan, M., Gamliel-Lazarovich, A., ACE2 of the heart: from angiotensin I to angiotensin (1-7) (2007) Cardiovasc. Res., 73, pp. 463-469. , https://academic.oup.com/cardiovascres/article/73/3/463/367423; He, R., Dobie, F., Ballantine, M., Analysis of multimerization of the SARS coronavirus nucleocapsid protein (2004) Biochem. Biophys. Res. Commun., 316, pp. 476-483. , https://www.sciencedirect.com/science/article/abs/pii/S0006291X04003250?via%3Dihub; Song, H.D., Tu, C.C., Zhang, G.W., Cross-host evolution of severe acute respiratory syndrome coronavirus in palm civet and human (2005) Proc. Natl. Acad. Sci. U.S.A., 102, pp. 2430-2435. , https://www.ncbi.nlm.nih.gov/pmc/articles/PMC548959/; Guan, Y., Zheng, B.J., He, Y.Q., Isolation and characterization of viruses related to the SARS coronavirus from animals in southern China (2003) Science, 302, pp. 276-278. , https://science.sciencemag.org/content/302/5643/276.long; Ge, X.Y., Li, J.L., Yang, X.L., Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor (2013) Nature, 503, pp. 535-538. , https://www.nature.com/articles/nature12711; Li, W., Zhang, C., Sui, J., Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2 (2005) EMBO J., 24, pp. 1634-1643. , https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1142572/; McGaughey, G.B., Gagné, M., Rappé, A.K., pi-Stacking interactions. Alive and well in proteins (1998) J. Biol. 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Virol., 79, pp. 15511-15524. , https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1316022/; Vieira Braga, F.A., Kar, G., Berg, M., A cellular census of human lungs identifies novel cell states in health and in asthma (2019) Nat. Med., 25, pp. 1153-1163. , https://www.nature.com/articles/s41591-019-0468-5; Xu, Y., Mizuno, T., Sridharan, A., Single-cell RNA sequencing identifies diverse roles of epithelial cells in idiopathic pulmonary fibrosis (2016) JCI Insight, 1. , https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5135277/; Hui, D.S.C., Zumla, A., Severe acute respiratory syndrome: historical, epidemiologic, and clinical features (2019) Infect. Dis. Clin., 33, pp. 869-889. , https://www.sciencedirect.com/science/article/pii/S0891552019300571?via%3Dihub; Holshue, M.L., DeBolt, C., Lindquist, S., First case of 2019 novel coronavirus in the United States (2020), https://www.nejm.org/doi/full/10.1056/NEJMoa2001191?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed, N Engl J Med Epub ahead of print; van der Hoek, L., Pyrc, K., Jebbink, M.F., Identification of a new human coronavirus (2004) Nat. Med., 10, pp. 368-373. , https://www.nature.com/articles/nm1024; Wu, K., Li, W., Peng, G., Li, F., Crystal structure of NL63 respiratory coronavirus receptor-binding domain complexed with its human receptor (2009) Proc. Natl. Acad. Sci. U. S. A., 106, pp. 19970-19974. , https://www.pnas.org/content/106/47/19970.long; Fielding, B.C., Human coronavirus NL63: a clinically important virus? (2011) Future Microbiol., 6, pp. 153-159. , https://www.futuremedicine.com/doi/full/10.2217/fmb.10.166?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&; Huentelman, M.J., Zubcevic, J., Hernández Prada Ja, J.A., Structure-based discovery of a novel angiotensin-converting enzyme 2 inhibitor (2004) Hypertension, 44, pp. 903-906; Culver, S., Li, C., Siragy, H.M., Intrarenal angiotensin-converting enzyme: the old and the new (2017) Curr. Hypertens. Rep., 19, p. 80. , https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5913745/; Guy, J.L., Jackson, R.M., Acharya, K.R., Angiotensin-converting enzyme-2 (ACE2): comparative modeling of the active site, specificity requirements, and chloride dependence (2003) Biochemistry, 42, pp. 13185-13192. , https://www.nature.com/articles/nature02145","Zhao, Z.J.; Edmond H. Fischer Translational Medical Research Laboratory, Precision Medicine Center, The Seventh Affiliated Hospital, Sun Yat-sen UniversityChina; email: joe-zhao@ouhsc.edu",,Elsevier B.V.,0006291X,,BBRCA,32081428,English,Biochem. Biophys. Res. Commun.,Article,Final,Open Access,Scopus,2-s2.0-85079618683,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Liu J., Zheng X., Tong Q., Li W., Wang B., Sutter K., Trilling M., Lu M., Dittmer U., Yang D.",55966706900;57215721456;57215854203;56532699100;57215852064;57210965828;24339193900;57215853909;7004161991;7404801457;,"Overlapping and discrete aspects of the pathology and pathogenesis of the emerging human pathogenic coronaviruses SARS-CoV, MERS-CoV, and 2019-nCoV",2020,Journal of Medical Virology,92,5,,491,494,,3,10.1002/jmv.25709,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080104612&doi=10.1002%2fjmv.25709&partnerID=40&md5=f0e6d5bbcb5f65d7b126dc3a032df4a7,"Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Institute for Virology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany; Joint International Laboratory of Infection and Immunity, Huazhong University of Science and Technology, Wuhan, Hubei, China","Liu, J., Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, Joint International Laboratory of Infection and Immunity, Huazhong University of Science and Technology, Wuhan, Hubei, China; Zheng, X., Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, Joint International Laboratory of Infection and Immunity, Huazhong University of Science and Technology, Wuhan, Hubei, China; Tong, Q., Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Li, W., Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Wang, B., Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, Joint International Laboratory of Infection and Immunity, Huazhong University of Science and Technology, Wuhan, Hubei, China; Sutter, K., Institute for Virology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany, Joint International Laboratory of Infection and Immunity, Huazhong University of Science and Technology, Wuhan, Hubei, China; Trilling, M., Institute for Virology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany, Joint International Laboratory of Infection and Immunity, Huazhong University of Science and Technology, Wuhan, Hubei, China; Lu, M., Institute for Virology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany, Joint International Laboratory of Infection and Immunity, Huazhong University of Science and Technology, Wuhan, Hubei, China; Dittmer, U., Institute for Virology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany, Joint International Laboratory of Infection and Immunity, Huazhong University of Science and Technology, Wuhan, Hubei, China; Yang, D., Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China, Joint International Laboratory of Infection and Immunity, Huazhong University of Science and Technology, Wuhan, Hubei, China","First reported from Wuhan, The People's Republic of China, on 31 December 2019, the ongoing outbreak of a novel coronavirus (2019-nCoV) causes great global concerns. Based on the advice of the International Health Regulations Emergency Committee and the fact that to date 24 other countries also reported cases, the WHO Director-General declared that the outbreak of 2019-nCoV constitutes a Public Health Emergency of International Concern on 30 January 2020. Together with the other two highly pathogenic coronaviruses, the severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), 2019-nCov and other yet to be identified coronaviruses pose a global threat to public health. In this mini-review, we provide a brief introduction to the pathology and pathogenesis of SARS-CoV and MERS-CoV and extrapolate this knowledge to the newly identified 2019-nCoV. © 2020 Wiley Periodicals, Inc.",coronavirus; immnopathology; immune responses; pathogenesis; respiratory tract; virus classification,"China; human; immune response; international health regulation; Middle East respiratory syndrome coronavirus; nonhuman; respiratory system; review; SARS coronavirus; virus classification; Betacoronavirus; communicable disease; Coronavirus infection; epidemic; Middle East respiratory syndrome coronavirus; pathogenicity; pathology; SARS coronavirus; severe acute respiratory syndrome; virology; virus pneumonia; COVID-19; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; China; Communicable Diseases, Emerging; Coronavirus Infections; Disease Outbreaks; Humans; Middle East Respiratory Syndrome Coronavirus; Pneumonia, Viral; SARS Virus; Severe Acute Respiratory Syndrome","(2019), http://wjw.wuhan.gov.cn/front/web/showDetail/2019123108989, Report of clustering pneumonia of unknown etiology in Wuhan City; 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Channappanavar, R., Fehr, A.R., Vijay, R., Dysregulated type I interferon and inflammatory monocyte-macrophage responses cause lethal pneumonia in SARS-CoV-infected mice (2016) Cell Host Microbe, 19 (2), pp. 181-193; Ng, D.L., Al Hosani, F., Keating, M.K., Clinicopathologic, immunohistochemical, and ultrastructural findings of a fatal case of Middle East respiratory syndrome coronavirus infection in the United Arab Emirates, April 2014 (2016) Am J Pathol, 186 (3), pp. 652-658; Alsaad, K.O., Hajeer, A.H., Al Balwi, M., Histopathology of Middle East respiratory syndrome coronovirus (MERS-CoV) infection—clinicopathological and ultrastructural study (2018) Histopathology, 72 (3), pp. 516-524; Walker, D.H., Value of autopsy emphasized in the case report of a single patient with Middle East respiratory syndrome (2016) Am J Pathol, 186 (3), pp. 507-510; Meyerholz, D.K., Lambertz, A.M., McCray, P.B., Jr., Dipeptidyl peptidase 4 distribution in the human respiratory tract: implications for the Middle East respiratory syndrome (2016) Am J Pathol, 186 (1), pp. 78-86; Cha, R., Yang, S.H., Moon, K.C., A case report of a middle east respiratory syndrome survivor with kidney biopsy results (2016) J Korean Med Sci, 31 (4), pp. 635-640; Widagdo, W., Raj, V.S., Schipper, D., Differential expression of the Middle East respiratory syndrome coronavirus receptor in the upper respiratory tracts of humans and dromedary camels (2016) J Virol, 90 (9), pp. 4838-4842; Song, Z., Xu, Y., Bao, L., From SARS to MERS, thrusting coronaviruses into the spotlight (2019) Viruses, 11 (1), p. 59; Chu, H., Zhou, J., Ho-Yin wong, B., Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response (2014) Virology, 454-455, pp. 197-205; Zhou, J., Chu, H., Li, C., Active replication of Middle East respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in human macrophages: implications for pathogenesis (2014) J Infect Dis, 209 (9), pp. 1331-1342; Chu, H., Zhou, J., Wong, B.H.Y., Middle East respiratory syndrome coronavirus efficiently infects human primary T lymphocytes and activates the extrinsic and intrinsic apoptosis pathways (2016) J Infect Dis, 213 (6), pp. 904-914; Yeung, M.L., Yao, Y., Jia, L., MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2 (2016) Nat Microbiol, 1; Wang, C., Horby, P.W., Hayden, F.G., Gao, G.F., A novel coronavirus outbreak of global health concern (2020) Lancet, 395, pp. 470-473; Ren, L.L., Wang, Y.M., Wu, Z.Q., Identification of a novel coronavirus causing severe pneumonia in human: a descriptive study (2020) Chin Med J, p. 1; Zhou, P., Yang, X.L., Wang, X.G., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395, pp. 507-513; Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med, , https://doi.org/10.1056/NEJMoa2001316; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506","Liu, J.; Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyChina; email: jialiu77@hust.edu.cn",,John Wiley and Sons Inc.,1466615,,JMVID,32056249,English,J. Med. Virol.,Review,Final,Open Access,Scopus,2-s2.0-85080104612,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhang L., Liu Y.",57215850526;55742019200;,Potential interventions for novel coronavirus in China: A systematic review,2020,Journal of Medical Virology,92,5,,479,490,,5,10.1002/jmv.25707,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080881381&doi=10.1002%2fjmv.25707&partnerID=40&md5=a111fa8995ffd319e060ae9cd8adb19e,"Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China","Zhang, L., Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China; Liu, Y., Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China","An outbreak of a novel coronavirus (COVID-19 or 2019-CoV) infection has posed significant threats to international health and the economy. In the absence of treatment for this virus, there is an urgent need to find alternative methods to control the spread of disease. Here, we have conducted an online search for all treatment options related to coronavirus infections as well as some RNA-virus infection and we have found that general treatments, coronavirus-specific treatments, and antiviral treatments should be useful in fighting COVID-19. We suggest that the nutritional status of each infected patient should be evaluated before the administration of general treatments and the current children's RNA-virus vaccines including influenza vaccine should be immunized for uninfected people and health care workers. In addition, convalescent plasma should be given to COVID-19 patients if it is available. In conclusion, we suggest that all the potential interventions be implemented to control the emerging COVID-19 if the infection is uncontrollable. © 2020 Wiley Periodicals, Inc.",2019-CoV; coronavirus; COVID-19; MERS; potential interventions; SARS,"alpha tocopherol; antivirus agent; ascorbic acid; chloroquine; cinanserin; cyclosporine; diarylheptanoid derivative; dipeptidyl carboxypeptidase inhibitor; emodin; flavonoid; immunoglobulin; interferon; iron; lopinavir plus ritonavir; monoclonal antibody; nelfinavir; nicotianamine; omega 3 fatty acid; polyunsaturated fatty acid; promazine; proteinase inhibitor; remdesivir; retinol; ribavirin; selenium; thymopentin; thymosin alpha1; unclassified drug; unindexed drug; vitamin B group; zinc; COVID-19; immunologic factor; severe acute respiratory syndrome coronavirus 2; trace element; virus vaccine; vitamin; antiviral therapy; China; Chinese medicine; coronavirus disease 2019; coronavirus disease 2019; diet therapy; human; infection control; nonhuman; Review; SARS coronavirus; severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; systematic review; virus infection; Betacoronavirus; China; Coronavirus infection; nutritional status; passive immunization; pathogenicity; plasma; virus pneumonia; Antiviral Agents; Betacoronavirus; China; Coronavirus Infections; Humans; Immunization, Passive; Immunologic Factors; Nutritional Status; Plasma; Pneumonia, Viral; Trace Elements; Viral Vaccines; Vitamins","Banerjee, A., Kulcsar, K., Misra, V., Frieman, M., Mossman, K., Bats and coronaviruses (2019) Viruses, 11, p. 41. , https://doi.org/10.3390/v11010041; Schoeman, D., Fielding, B.C., Coronavirus envelope protein: current knowledge (2019) Virol J, 16, p. 69. , https://doi.org/10.1186/s12985-019-1182-0; Zumla, A., Hui, D.S., Perlman, S., Middle East respiratory syndrome (2015) Lancet, 386, pp. 995-1007. , https://doi.org/10.1016/S0140-6736(15)60454-8; Cohen, J., Normile, D., New SARS-like virus in China triggers alarm (2020) Science, 367, pp. 234-235. , https://doi.org/10.1126/science.367.6475.234; 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(2016) Blood Transfus, 14, pp. 152-157. , https://doi.org/10.2450/2015.0131-15; Arabi, Y., Balkhy, H., Hajeer, A.H., Feasibility, safety, clinical, and laboratory effects of convalescent plasma therapy for patients with Middle East respiratory syndrome coronavirus infection: a study protocol (2015) Springerplus, 4, p. 709. , https://doi.org/10.1186/s40064-015-1490-9; Cheng, Y., Wong, R., Soo, Y.O.Y., Use of convalescent plasma therapy in SARS patients in Hong Kong (2005) Eur J Clin Microbiol Infect Dis, 24, pp. 44-46. , https://doi.org/10.1007/s10096-004-1271-9; Soo, Y.O.Y., Cheng, Y., Wong, R., Retrospective comparison of convalescent plasma with continuing high-dose methylprednisolone treatment in SARS patients (2004) Clin Microbiol Infect, 10, pp. 676-678. , https://doi.org/10.1111/j.1469-0691.2004.00956.x","Liu, Y.; Department of Neurosurgery, Shengjing Hospital of China Medical UniversityChina; email: liuyh@sj-hospital.org",,John Wiley and Sons Inc.,1466615,,JMVID,32052466,English,J. Med. Virol.,Review,Final,Open Access,Scopus,2-s2.0-85080881381,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Ceraolo C., Giorgi F.M.",57215079381;57205652168;,Genomic variance of the 2019-nCoV coronavirus,2020,Journal of Medical Virology,92,5,,522,528,,4,10.1002/jmv.25700,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079840316&doi=10.1002%2fjmv.25700&partnerID=40&md5=c4f6f1b2282961a8dfe2cb5fd8fb427b,"Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy","Ceraolo, C., Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy; Giorgi, F.M., Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy","There is a rising global concern for the recently emerged novel coronavirus (2019-nCoV). Full genomic sequences have been released by the worldwide scientific community in the last few weeks to understand the evolutionary origin and molecular characteristics of this virus. Taking advantage of all the genomic information currently available, we constructed a phylogenetic tree including also representatives of other coronaviridae, such as Bat coronavirus (BCoV) and severe acute respiratory syndrome. We confirm high sequence similarity (>99%) between all sequenced 2019-nCoVs genomes available, with the closest BCoV sequence sharing 96.2% sequence identity, confirming the notion of a zoonotic origin of 2019-nCoV. Despite the low heterogeneity of the 2019-nCoV genomes, we could identify at least two hypervariable genomic hotspots, one of which is responsible for a Serine/Leucine variation in the viral ORF8-encoded protein. Finally, we perform a full proteomic comparison with other coronaviridae, identifying key aminoacidic differences to be considered for antiviral strategies deriving from previous anti-coronavirus approaches. © 2020 Wiley Periodicals, Inc.",biostatistics & bioinformatics; CLUSTAL analysis; coronavirus; data visualization; virus classification,"leucine; serine; COVID-19; proteome; severe acute respiratory syndrome coronavirus 2; virus RNA; Article; Bat coronavirus; Betacoronavirus; comparative proteomics; gene sequence; genetic heterogeneity; genetic variability; nonhuman; nucleotide sequence; open reading frame; phylogenetic tree; SARS coronavirus; sequence homology; Severe acute respiratory syndrome coronavirus 2; virus genome; amino acid sequence; animal; bat; Betacoronavirus; biological model; classification; Coronavirus infection; genetic variation; genetics; human; phylogeny; virology; virus pneumonia; Amino Acid Sequence; Animals; Base Sequence; Betacoronavirus; Chiroptera; Coronavirus Infections; Genetic Variation; Genome, Viral; Humans; Models, Genetic; Phylogeny; Pneumonia, Viral; Proteome; RNA, Viral","Cui, J., Li, F., Shi, Z.-L., Origin and evolution of pathogenic coronaviruses (2019) Nat Rev Microbiol, 17 (3), pp. 181-192. , https://doi.org/10.1038/s41579-018-0118-9; Schoeman, D., Fielding, B.C., Coronavirus envelope protein: current knowledge (2019) Virol J, 16 (1), p. 69. , https://doi.org/10.1186/s12985-019-1182-0; Hu, B., Ge, X., Wang, L.-F., Shi, Z., Bat origin of human coronaviruses (2015) Virol J, 12 (1), p. 221. , https://doi.org/10.1186/s12985-015-0422-1; Benvenuto, D., Giovannetti, M., Ciccozzi, A., Spoto, S., Angeletti, S., Ciccozzi, M., The 2019-new coronavirus epidemic: evidence for virus evolution (2020) J Med Virol, , https://doi.org/10.1002/jmv.25688; Lu, H., Stratton, C.W., Tang, Y., Outbreak of pneumonia of unknown etiology in Wuhan China: the mystery and the miracle (2020) J Med Virol, , https://doi.org/10.1002/jmv.25678; Lu, R., Zhao, X., Li, J., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) The Lancet, , https://doi.org/10.1016/S0140-6736(20)30251-8; Shu, Y., McCauley, J., GISAID: global initiative on sharing all influenza data—from vision to reality (2017) Euro Surveill, 22 (13), pp. 1-3. , https://doi.org/10.2807/1560-7917.ES.2017.22.13.30494; Sayers, E.W., Cavanaugh, M., Clark, K., Ostell, J., Pruitt, K.D., Karsch-Mizrachi, I., GenBank (2019) Nucleic Acids Res, 47 (D1), pp. D94-D99. , https://doi.org/10.1093/nar/gky989; Edgar, R.C., MUSCLE: multiple sequence alignment with high accuracy and high throughput (2004) Nucleic Acids Res, 32 (5), pp. 1792-1797. , https://doi.org/10.1093/nar/gkh340; Waterhouse, A.M., Procter, J.B., Martin, D.M.A., Clamp, M., Barton, G.J., Jalview Version 2—a multiple sequence alignment editor and analysis workbench (2009) Bioinformatics, 25 (9), pp. 1189-1191. , https://doi.org/10.1093/bioinformatics/btp033; Kumar, S., Stecher, G., Li, M., Knyaz, C., Tamura, K., MEGA X: molecular evolutionary genetics analysis across computing platforms (2018) Mol Biol Evol, 35 (6), pp. 1547-1549. , https://doi.org/10.1093/molbev/msy096; Tamura, K., Nei, M., Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees (1993) Mol Biol Evol, 10 (3), pp. 512-526. , https://doi.org/10.1093/oxfordjournals.molbev.a040023; Felsenstein, J., Confidence limits on phylogenies: an approach using the bootstrap (1985) Evolution, 39 (4), pp. 783-791. , https://doi.org/10.1111/j.1558-5646.1985.tb00420.x; Le, S., Joss, J., Husson, F., FactoMineR: an R package for multivariate analysis (2008) J Stat Softw, 25 (1), pp. 1-18; Altschul, S.F., Gish, W., Miller, W., Myers, E.W., Lipman, D.J., Basic local alignment search tool (1990) J Mol Biol, 215 (3), pp. 403-410. , https://doi.org/10.1016/S0022-2836(05)80360-2; Linding, R., GlobPlot: exploring protein sequences for globularity and disorder (2003) Nucleic Acids Res, 31 (13), pp. 3701-3708. , https://doi.org/10.1093/nar/gkg519; Narayanan, K., Huang, C., Makino, S., SARS coronavirus accessory proteins (2008) Virus Res, 133 (1), pp. 113-121. , https://doi.org/10.1016/j.virusres.2007.10.009; Manaresi, E., Conti, I., Bua, G., Bonvicini, F., Gallinella, G., A Parvovirus B19 synthetic genome: sequence features and functional competence (2017) Virology, 508, pp. 54-62. , https://doi.org/10.1016/j.virol.2017.05.006; Burley, S.K., Berman, H.M., Kleywegt, G.J., Markley, J.L., Nakamura, H., Velankar, S., Protein Data Bank (PDB): The Single Global Macromolecular Structure Archive (2017) Protein Crystallography, 1607, pp. 627-641. , Wlodawer A, Dauter Z, Jaskolski M, eds., New York, NY, Springer New York; Anand, K., Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs (2003) Science, 300 (5626), pp. 1763-1767. , https://doi.org/10.1126/science.1085658","Giorgi, F.M.; Department of Pharmacy and Biotechnology, University of BolognaItaly; email: federico.giorgi@unibo.it",,John Wiley and Sons Inc.,1466615,,JMVID,32027036,English,J. Med. Virol.,Article,Final,Open Access,Scopus,2-s2.0-85079840316,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Liu K.-C., Xu P., Lv W.-F., Qiu X.-H., Yao J.-L., Gu J.-F., Wei W.",57215695651;57215694758;57215689286;57202922119;57215698716;57215686809;57215680439;,CT manifestations of coronavirus disease-2019: A retrospective analysis of 73 cases by disease severity,2020,European Journal of Radiology,126,,108941,,,,,10.1016/j.ejrad.2020.108941,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081680373&doi=10.1016%2fj.ejrad.2020.108941&partnerID=40&md5=b73d4f15ad45f4e9b98b23ef3a8775a2,"Infection Hospital, Anhui Provincial Hospital, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui Province 230022, China; Department of Respiratory, Hefei Second People's Hospital, Hefei Hospital Affiliated to Anhui Medical University, 1 Guangde Road, Hefei, Anhui Province 230011, China; Department of Radiology, Anhui Provincial Hospital, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, 4 Lujiang Road, Hefei, Anhui Province 230001, China; Department of Radiology, Bo Zhou People's Hospital, 3 Xiyi Avenue, Qiaocheng District, Bozhou, Anhui Province 236800, China; Department of Radiology, Tongling People's Hospital, 468 Bijiashan Road, Tongling, Anhui Province 244000, China; Department of Radiology, Fuyang Second People's Hospital, 450 Linquan Road, Yingzhou District, Fuyang, Anhui Province 236015, China","Liu, K.-C., Infection Hospital, Anhui Provincial Hospital, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui Province 230022, China; Xu, P., Department of Respiratory, Hefei Second People's Hospital, Hefei Hospital Affiliated to Anhui Medical University, 1 Guangde Road, Hefei, Anhui Province 230011, China; Lv, W.-F., Department of Radiology, Anhui Provincial Hospital, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, 4 Lujiang Road, Hefei, Anhui Province 230001, China; Qiu, X.-H., Department of Radiology, Bo Zhou People's Hospital, 3 Xiyi Avenue, Qiaocheng District, Bozhou, Anhui Province 236800, China; Yao, J.-L., Department of Radiology, Tongling People's Hospital, 468 Bijiashan Road, Tongling, Anhui Province 244000, China; Gu, J.-F., Department of Radiology, Fuyang Second People's Hospital, 450 Linquan Road, Yingzhou District, Fuyang, Anhui Province 236015, China; Wei, W., Department of Radiology, Anhui Provincial Hospital, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, 4 Lujiang Road, Hefei, Anhui Province 230001, China","Purpose: To report CT features of coronavirus disease-2019 (COVID-19) in patients with various disease severity. Methods: The CT manifestations and clinical data of 73 patients with COVID-19 were retrospectively collected in 6 hospitals from Jan 21 to Feb 3, 2020. We analyzed the initial and follow-up CT features of patients with disease severity, according to the Guidelines for the Diagnosis and Treatment of New Coronavirus Pneumonia. Results: Six patients (8%) were diagnosed as mild type pneumonia; these patients had no obvious abnormal CT findings or manifested mild changes of lung infection. All 43 patients (59 %) with common type presented unique or multiple ground-glass opacities (GGO) in the periphery of the lungs, with or without interlobular septal thickening. In the 21 patients (29 %) with severe type, extensive GGO and pulmonary consolidation were found in 16 cases (16/21, 76 %) and 5 cases (24 %), respectively. An extensive ""white lung"", with atelectasis and pleural effusion were found in critical type patients (3, 4%). On the resolutive phase of the disease, CT abnormalities showed complete resolution, or demonstrated residual linear opacities. Conclusions: Different CT features are seen according to disease severity, which can help COVID-19 stratification. © 2020 The Author(s)",Computer tomography; Coronavirus disease-2019; Diagnosis; Pneumonia; X-ray,antivirus agent; adolescent; adult; aged; Article; atelectasis; child; clinical assessment; controlled study; coronavirus disease 2019; Coronavirus infection; disease severity; female; follow up; human; image analysis; image display; lung infection; major clinical study; male; multidetector computed tomography; pleura effusion; practice guideline; priority journal; retrospective study; virus pneumonia,"WHO, Novel Coronavirus – China (2020), http://www.who.int/csr/don/12-january-2020-novel-coronavirus-china/en/, Jan 12 (Accessed Jan 19, 2020); Huang, C.L., Wang, Y.M., Li, X.W., Ren, L.L., Zhao, J.P., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395 (10223), pp. 497-506; Chen, N.S., Zhou, M., Dong, X., Qu, J.M., Gong, F.Y., Han, Y., Qiu, Y., Zhang, L., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395 (10223), pp. 507-513; Patel, A., Jernigan, D.B., 2019-nCoV CDC Response Team, Initial public health response and interim clinical guidance for the 2019 novel coronavirus outbreak - United States, December 31, 2019-February 4, 2020 (2020) Am. J. Transplant., 20 (3), pp. 889-895; Backer, J.A., Klinkenberg, D., Wallinga, J., The incubation period of 2019-nCoV infections among travelers from Wuhan, China (2020) Euro Surveill., 25 (5); Li, G., Fan, Y.H., Lai, Y.N., Han, T.T., Li, Z.H., Zhou, P.W., Pan, P., Wu, J.G., Coronavirus infections and immune responses (2020) J. Med. Virol., 92 (4), pp. 424-432; National Health Commission of the people's Republic of China, The Guidelines for the Diagnosis and Treatment of New Coronavirus Pneumonia (2020), fifth edition; Zhang, N.R., Wang, L.L., Deng, X.Q., Liang, R.Y., Su, M., He, C., Hu, L.F., Jiang, S.B., Recent advances in the detection of respiratory virus infection in humans (2020) J. Med. Virol., 92 (4), pp. 408-417; Lu, R.J., Zhao, X., Li, J., Niu, P.H., Yang, B., Wu, H.L., Wang, W.L., Tan, W.J., Genomic characterisation and epidemiology of 2019 novel coronavirus implications for virus origins and receptor binding (2020) Lancet, 395 (10224), pp. 565-574; Tan, D.Y., Zhu, H.D., Fu, Y.Y., Tong, F., Yao, D.Q., Walline, J., Xu, J., Yu, X.Z., Severe community-acquired pneumonia caused by human adenovirus in immunocompetent adults: a multicenter case series (2016) PLoS One, 11 (3); Li, P., Zhang, J.F., Xia, X.D., Su, D.J., Liu, B.L., Zhao, D.L., Liu, Y., Zhao, D.H., Serial evaluation of high-resolution CT findings in patients with pneumonia in novel swine-origin influenza A (H1N1) virus infection (2014) Br. J. Radiol., 85 (1014), pp. 729-735; Wang, J.T., Sheng, W.H., Fang, C.T., Chen, Y.C., Wang, J.L., Yu, C.J., Chang, S.C., Yang, P.C., Clinical manifestations, laboratory findings, and treatment outcomes of SARS patients (2004) Emerg. Infect. Dis., 10 (5), pp. 818-824; Bernheim, A., Mei, X., Huang, M., Yang, Y., Fayad, Z.A., Zhang, N., Diao, K., Chung, M., Chest CT findings in coronavirus disease-19 (COVID-19): relationship to duration of infection (2020) Radiology, (February), p. 200463","Xu, P.; Department of Respiratory, Hefei Second People's Hospital, Hefei Hospital Affiliated to Anhui Medical University, 1 Guangde Road, China; email: xuping1027@163.com",,Elsevier Ireland Ltd,0720048X,,EJRAD,,English,Eur. J. Radiol.,Article,Final,Open Access,Scopus,2-s2.0-85081680373,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Giwa A.L., Desai A., Duca A.",57216003529;57215380607;57040952100;,Novel 2019 coronavirus SARS-CoV-2 (COVID-19): An updated overview for emergency clinicians,2020,Emergency medicine practice,22,5,,1,28,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082271234&partnerID=40&md5=da6fc8db936f6ce7afe03c617b5cfea8,"Associate Professor of Emergency Medicine, Icahn School of Medicine at Mount Sinai, NY, NY; Icahn School of Medicine at Mount Sinai, NY, NY; Department of Emergency Medicine, Ospedale Papa Giovanni XXIII, Bergamo, Italy","Giwa, A.L., Associate Professor of Emergency Medicine, Icahn School of Medicine at Mount Sinai, NY, NY; Desai, A., Icahn School of Medicine at Mount Sinai, NY, NY; Duca, A., Department of Emergency Medicine, Ospedale Papa Giovanni XXIII, Bergamo, Italy","The novel coronavirus, COVID-19, has quickly become a worldwide threat to health, travel, and commerce. This overview analyzes the best information from the early research, including epidemiologic and demographic features from SARS-CoV-1 and MERS-CoV viruses; lessons learned from the experience of an emergency physician in Northern Italy, where the outbreak has devastated the healthcare system; evidence on transmission and prevention through safe use of PPE; evidence and advice on SARS-CoV-2 testing and co-infection; management options; airway management options; steps for rapid sequence intubation in the ED and managing disaster ventilation; and information on managing pediatric and pregnant patients.",,"monoxerutin; adult; artificial ventilation; Betacoronavirus; child; Coronavirus infection; disaster planning; disease transmission; female; genetics; hospital emergency service; human; infection control; intubation; Italy; male; pathogenicity; pregnancy; pregnancy complication; prevention and control; procedures; protective equipment; respiration control; virus pneumonia; Adult; Airway Management; Betacoronavirus; Child; Coronavirus Infections; Disaster Planning; Emergency Service, Hospital; Female; Humans; Hydroxyethylrutoside; Infection Control; Infectious Disease Transmission, Patient-to-Professional; Intubation; Italy; Male; Personal Protective Equipment; Pneumonia, Viral; Pregnancy; Pregnancy Complications, Infectious; Respiration, Artificial",,,,NLM (Medline),15593908,,,32207910,English,Emerg Med Pract,Article,Final,,Scopus,2-s2.0-85082271234,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Lima C.K.T., Carvalho P.M.D.M., Lima I.D.A.A.S., Nunes J.V.A.D.O., Saraiva J.S., de Souza R.I., da Silva C.G.L., Neto M.L.R.",56647609500;57215502475;57215858333;57215860446;57215861684;57215860587;56085499700;54882487200;,The emotional impact of Coronavirus 2019-nCoV (new Coronavirus disease),2020,Psychiatry Research,287,,112915,,,,,10.1016/j.psychres.2020.112915,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082117705&doi=10.1016%2fj.psychres.2020.112915&partnerID=40&md5=c27ab5cda61b7fc76f8ebb5fe9d1a98c,"PostGraduate Program in Health Sciences, School of Medicine of ABC, Santo André, São Paulo, Brazil; School of Medicine of Juazeiro do Norte – FMJ/Estácio, Juazeiro do Norte, Ceará, Brazil; School of Medicine, Federal University of Cariri (UFCA), Barbalha, Ceará, Brazil","Lima, C.K.T., PostGraduate Program in Health Sciences, School of Medicine of ABC, Santo André, São Paulo, Brazil; Carvalho, P.M.D.M., PostGraduate Program in Health Sciences, School of Medicine of ABC, Santo André, São Paulo, Brazil; Lima, I.D.A.A.S., School of Medicine of Juazeiro do Norte – FMJ/Estácio, Juazeiro do Norte, Ceará, Brazil; Nunes, J.V.A.D.O., School of Medicine of Juazeiro do Norte – FMJ/Estácio, Juazeiro do Norte, Ceará, Brazil; Saraiva, J.S., School of Medicine of Juazeiro do Norte – FMJ/Estácio, Juazeiro do Norte, Ceará, Brazil; de Souza, R.I., School of Medicine of Juazeiro do Norte – FMJ/Estácio, Juazeiro do Norte, Ceará, Brazil; da Silva, C.G.L., School of Medicine of Juazeiro do Norte – FMJ/Estácio, Juazeiro do Norte, Ceará, Brazil, School of Medicine, Federal University of Cariri (UFCA), Barbalha, Ceará, Brazil; Neto, M.L.R., School of Medicine of Juazeiro do Norte – FMJ/Estácio, Juazeiro do Norte, Ceará, Brazil, School of Medicine, Federal University of Cariri (UFCA), Barbalha, Ceará, Brazil","Background: : A novel form of Coronavirus (2019-nCoV) in Wuhan has created a confused and rapidly evolving situation. In this situational framework, patients and front-line healthcare workers are vulnerable. Method: : Studies were identified using large-circulation international journals found in two electronic databases: Scopus and Embase. Results: : Populations of patients that may require tailored interventions are older adults and international migrant workers. Older adults with psychiatric conditions may be experiencing further distress. The COVID-19 epidemic has underscored potential gaps in mental health services during emergencies. Conclusions: : Most health professionals working in isolation units and hospitals do not receive any training for providing mental health care. Fear seems more certainly a consequence of mass quarantine. © 2020 Elsevier B.V.",Coronavirus (2019-nCoV); Emergencies; Mental health; Psychological problems,,"Barbisch, D., Koenig, K.L., Shih, F.Y., Is there a case for quarantine? Perspectives from to Ebola (2015) Disaster Med. Public Health Prep., 9, pp. 547-553; Duan, L., Zhu, G., Psychological interventions for people affected by the COVID-19 epidemic (2020) Lancet Psychiatry.; Folkman, S., Greer, S., Promoting psychological well-being in the face of serious illness: when theory, research and practice inform each other (2000) Psychooncology, 9, pp. 11-19; Huang, X., Huang, X., Li, X., Tao, Q., Li, H., Li, J., The effect of equilibrium psychological intervention in wounded patients in Lushan earthquake (article in Chinese) (2014) J. Sichuan University (Med. Sci. Edi.), 45, pp. 533-535; Liem, A., Wang, C., Wariyanti, Y., Latkin, C.A., Hall, B.J., The neglected health of international migrant workers in the COVID-19 epidemic (2020) Lancet Psychiatry.; Lin, C., Chen, Q., Tian, Y., The construction and evaluation of experts-coach-teacher collaboration model as a new trauma intervention approach (article in Chinese) (2018) J. Beijing Norm. University, 2, pp. 32-40; Liu, S., Yang, L., Zhang, C., Xiang, Y.T., Liu, S., Hu, S., Zhang, B., Online mental health services in China during the COVID-19 outbreak (2020) Lancet Psychiatry.; Maunder, R., Hunter, J., Vicent, L., Bennett, J., Peladeau, N., Leszcz, M., Sadavoy, J., Mazzulli, T., The immediate psychological and occupational impact of the 2003 SARS outbreak in a teaching hospital (2003) CMAJ, 168, pp. 1245-1251. , https://www.cmaj.ca/content/168/10/1245.long; (2020), http://www.nhc.gov.cn/jkj/s3577/202002/f389f20cc1174b21b981ea2919beb8b0.shtml, National Health Commission of China Guidelines for psychological assistance hotlines during 2019-nCoV Pneumonia epidemic (in Chinese); Rubin, G.J., Wessely, S., Coronavirus: the psychological effects of quarantining a city (2020) The BMJ Opinion., , https://blogs.bmj.com/bmj/2020/01/24/coronavirus-the-psychological-effects-of-quarantining-a-city/; Williams, B., (2020), https://www.psychiatryadvisor.com/home/topics/general-psychiatry/mental-health-concerns-arise-amid-covid-19-epidemic/, Mental health concerns arise amid COVID-19 epidemic. psychiatry advisor; Xiang, Y.T., Yang, Y., Li, W., Zhang, L., Zhang, Q., Cheung, T., Ng, C.H., Timely mental health care for the 2019 novel Coronavirus outbreak is urgently needed (2020) Lancet Psychiatry, 7, pp. 228-229; Yang, Y., Li, W., Zhang, Q., Zhang, L., Cheung, T., Xiang, Y.T., Mental health services for older adults in China during the COVID-19 outbreak (2020) Lancet Psychiatry.; Zhang, J., Wu, W., Zhao, Z., Zhang, W., Recommended psychological crisis intervention response to the 2019 novel Coronavirus pneumonia outbreak in China: a model of west China hospital (2020) Precis. Clinical Med., , pbaa006","Neto, M.L.R.; School of Medicine, Federal University of Cariri, UFCABrazil; email: modesto.neto@ufca.edu.br",,Elsevier Ireland Ltd,1651781,,PSRSD,32199182,English,Psychiatry Res.,Letter,Final,Open Access,Scopus,2-s2.0-85082117705,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhang W., Zhao Y., Zhang F., Wang Q., Li T., Liu Z., Wang J., Qin Y., Zhang X., Yan X., Zeng X., Zhang S.",57215190361;56179130600;57205293504;57215937277;55776190500;55659798100;57215938253;57215936161;57215937257;7403596193;10046437000;16231911900;,The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): The experience of clinical immunologists from China,2020,Clinical Immunology,214,,108393,,,,,10.1016/j.clim.2020.108393,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082425864&doi=10.1016%2fj.clim.2020.108393&partnerID=40&md5=addd934f6e341f87664f9acf78de62de,"Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences (CAMS), Peking Union Medical College Hospital, The Ministry of Education Key Laboratory, National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing, 100730, China; Clinical Immunology Centre, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100730, China; Department of Infectious Disease, Chinese Academy of Medical Sciences (CAMS), Peking Union Medical College Hospital, Beijing, 100730, China; Department of Respiratory Medicine, Chinese Academy of Medical Sciences (CAMS), Peking Union Medical College Hospital, Beijing, 100730, China; Department of Nephrology, Chinese Academy of Medical Sciences (CAMS), Peking Union Medical College Hospital, Beijing, 100730, China; Department of Cardiology, Chinese Academy of Medical Sciences (CAMS), Peking Union Medical College Hospital, Beijing, 100730, China; Intensive Care Unit (ICU) for COVID-19, Wu Han Tong Ji Hospital, Wuhan City, Hubei Province 200065, China","Zhang, W., Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences (CAMS), Peking Union Medical College Hospital, The Ministry of Education Key Laboratory, National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing, 100730, China; Zhao, Y., Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences (CAMS), Peking Union Medical College Hospital, The Ministry of Education Key Laboratory, National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing, 100730, China; Zhang, F., Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences (CAMS), Peking Union Medical College Hospital, The Ministry of Education Key Laboratory, National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing, 100730, China; Wang, Q., Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences (CAMS), Peking Union Medical College Hospital, The Ministry of Education Key Laboratory, National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing, 100730, China; Li, T., Clinical Immunology Centre, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100730, China, Department of Infectious Disease, Chinese Academy of Medical Sciences (CAMS), Peking Union Medical College Hospital, Beijing, 100730, China, Intensive Care Unit (ICU) for COVID-19, Wu Han Tong Ji Hospital, Wuhan City, Hubei Province 200065, China; Liu, Z., Department of Infectious Disease, Chinese Academy of Medical Sciences (CAMS), Peking Union Medical College Hospital, Beijing, 100730, China, Intensive Care Unit (ICU) for COVID-19, Wu Han Tong Ji Hospital, Wuhan City, Hubei Province 200065, China; Wang, J., Department of Respiratory Medicine, Chinese Academy of Medical Sciences (CAMS), Peking Union Medical College Hospital, Beijing, 100730, China, Intensive Care Unit (ICU) for COVID-19, Wu Han Tong Ji Hospital, Wuhan City, Hubei Province 200065, China; Qin, Y., Department of Nephrology, Chinese Academy of Medical Sciences (CAMS), Peking Union Medical College Hospital, Beijing, 100730, China, Intensive Care Unit (ICU) for COVID-19, Wu Han Tong Ji Hospital, Wuhan City, Hubei Province 200065, China; Zhang, X., Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences (CAMS), Peking Union Medical College Hospital, The Ministry of Education Key Laboratory, National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing, 100730, China, Clinical Immunology Centre, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, 100730, China; Yan, X., Department of Cardiology, Chinese Academy of Medical Sciences (CAMS), Peking Union Medical College Hospital, Beijing, 100730, China, Intensive Care Unit (ICU) for COVID-19, Wu Han Tong Ji Hospital, Wuhan City, Hubei Province 200065, China; Zeng, X., Department of Rheumatology and Clinical Immunology, Chinese Academy of Medical Sciences (CAMS), Peking Union Medical College Hospital, The Ministry of Education Key Laboratory, National Clinical Research Center for Dermatologic and Immunologic Diseases, Beijing, 100730, China; Zhang, S., Department of Cardiology, Chinese Academy of Medical Sciences (CAMS), Peking Union Medical College Hospital, Beijing, 100730, China, Intensive Care Unit (ICU) for COVID-19, Wu Han Tong Ji Hospital, Wuhan City, Hubei Province 200065, China","The pandemic outbreak of coronavirus disease 2019 (COVID-19) is rapidly spreading all over the world. Reports from China showed that about 20% of patients developed severe disease, resulting in a fatality of 4%. In the past two months, we clinical immunologists participated in multi-rounds of MDT (multidiscipline team) discussion on the anti-inflammation management of critical COVID-19 patients, with our colleagues dispatched from Chinese leading PUMC Hospital to Wuhan to admit and treat the most severe patients. Here, from the perspective of clinical immunologists, we will discuss the clinical and immunological characteristics of severe patients, and summarize the current evidence and share our experience in anti-inflammation treatment, including glucocorticoids, IL-6 antagonist, JAK inhibitors and choloroquine/hydrocholoroquine, of patients with severe COVID-19 that may have an impaired immune system. © 2020",Anti-inflammation treatment; Coronavirus disease 2019 (COVID-19); Cytokine storm,,"Channappanavar, R., Perlman, S., Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology (2017) Semin. Immunopathol., 39, pp. 529-539; Chousterman, B.G., Swirski, F.K., Weber, G.F., Cytokine storm and sepsis disease pathogenesis (2017) Semin. Immunopathol., 39, pp. 517-528; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506; Conti, P., Ronconi, G., Caraffa, A., Gallenga, C.E., Ross, R., Frydas, I., Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): anti-inflammatory strategies (2020) J. Biol. Regul. Homeost. Agents, 34; Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study (2020) Lancet; Ruan, Q., Yang, K., Wang, W., Jiang, L., Song, J., Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China (2020) Intensive Care Med., , Mar 3; Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395, pp. 507-513; Wu, C., Chen, X., Cai, Y., Xia, J., Zhou, X., Xu, S., Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China (2020) JAMA Intern. Med.; Wan, S., Yi, Q., Fan, S., Lv, J., Zhang, X., Guo, L., Characteristics of lymphocyte subsets and cytokines in peripheral blood of 123 hospitalized patients with 2019 novel coronavirus pneumonia (NCP) (2020) medRxiv; Xu, Z., Shi, L., Wang, Y., Zhang, J., Huang, L., Zhang, C., Pathological findings of COVID-19 associated with acute respiratory distress syndrome (2020) Lancet Respir. Med.; Siddiqi, H.K., Mehra, M.R., COVID-19 illness in native and immunosuppressed states: a clinical-therapeutic staging proposal (2020) J. Heart Lung Transplant.; National Health Commission of the People's Republic of China, The Diagnosis and Treatment Plan for 2019-nCoV (The Seventh Trial Edition) http://www.nhc.gov.cn/yzygj/s7653p/202003/46c9294a7dfe4cef80dc7f5912eb1989.shtml, (accessed 4 March 2020); Qin, C., Zhou, L., Hu, Z., Zhang, S., Yang, S., Tao, Y., Dysregulation of immune response in patients with COVID-19 in Wuhan, China (2020) Clin. Infect. Dis.; Yao, X.H., Li, T.Y., He, Z.C., Ping, Y.F., Liu, H.W., Yu, S.C., A pathological report of three COVID-19 cases by minimally invasive autopsies (2020) Chin. J. Pathol., 49; Guo, X., Thomas, P., New fronts emerge in the influenza cytokine storm (2017) Semin. Immunopathol., 39, pp. 541-550; Shimabukuro-Vornhagen, A., Gödel, P., Subklewe, M., Stemmler, H.J., Schlößer, H.A., Schlaak, M., Cytokine release syndrome (2018) J. Immunother. Cancer, 6, p. 56; Chen, C., Zhang, X.R., Ju, Z.Y., He, W.F., Advances in the research of cytokine storm mechanism induced by Corona virus disease 2019 and the corresponding immunotherapies (2020) Chin. J. Burns, 36; Auyeung, T.W., Lee, J.S., Lai, W.K., Choi, C.H., Lee, H.K., Lee, J.S., The use of corticosteroid as treatment in SARS was associated with adverse outcomes: a retrospective cohort study (2005) J. Inf. Secur., 51, pp. 98-102; Ho, J.C., Ooi, G.C., Mok, T.Y., Chan, J.W., Hung, I., Lam, B., High-dose pulse versus nonpulse corticosteroid regimens in severe acute respiratory syndrome (2003) Am. J. Respir. Crit. Care Med., 168, pp. 1449-1456; Yam, L.Y., Lau, A.C., Lai, F.Y., Shung, E., Chan, J., Wong, V., Corticosteroid treatment of severe acute respiratory syndrome in Hong Kong (2007) J. Inf. Secur., 54, pp. 28-39; Chen, R.C., Tang, X.P., Tan, S.Y., Liang, B.L., Wan, Z.Y., Fang, J.Q., Treatment of severe acute respiratory syndrome with glucosteroids: the Guangzhou experience (2006) Chest, 129, pp. 1441-1452; Rhodes, A., Evans, L.E., Alhazzani, W., Levy, M.M., Antonelli, M., Ferrer, R., Kumar, A., Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016 (2017) Intensive Care Med., 43, pp. 304-377; Sun, P., Lu, X., Xu, C., Sun, W., Pan, B., Understanding of COVID-19 based on current evidence (2020) J. Med. Virol.; Chan, K.W., Wong, V.T., Tang, S.C.W., COVID-19: an update on the epidemiological, clinical, preventive and therapeutic evidence and guidelines of integrative Chinese-Western medicine for the management of 2019 novel coronavirus disease (2020) Am. J. Chin. 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Ther., 14, pp. 58-60","Yan, X.; Department of Cardiology, Chinese Academy of Medical Sciences (CAMS), Peking Union Medical College HospitalChina; email: xswy_pumc@163.com",,Academic Press Inc.,15216616,,CLIIF,,English,Clin. Immunol.,Review,Final,Open Access,Scopus,2-s2.0-85082425864,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Santosh K.C.,14831502300;,AI-Driven Tools for Coronavirus Outbreak: Need of Active Learning and Cross-Population Train/Test Models on Multitudinal/Multimodal Data,2020,Journal of Medical Systems,44,5,93,,,,,10.1007/s10916-020-01562-1,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082143057&doi=10.1007%2fs10916-020-01562-1&partnerID=40&md5=587b1dde04495c771e6f18361e2759ac,"Department of Computer Science, University of South Dakota, 414 E Clark St, Vermillion, SD 57069, United States","Santosh, K.C., Department of Computer Science, University of South Dakota, 414 E Clark St, Vermillion, SD 57069, United States","The novel coronavirus (COVID-19) outbreak, which was identified in late 2019, requires special attention because of its future epidemics and possible global threats. Beside clinical procedures and treatments, since Artificial Intelligence (AI) promises a new paradigm for healthcare, several different AI tools that are built upon Machine Learning (ML) algorithms are employed for analyzing data and decision-making processes. This means that AI-driven tools help identify COVID-19 outbreaks as well as forecast their nature of spread across the globe. However, unlike other healthcare issues, for COVID-19, to detect COVID-19, AI-driven tools are expected to have active learning-based cross-population train/test models that employs multitudinal and multimodal data, which is the primary purpose of the paper. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.",Active learning; Artificial intelligence; COVID-19; Cross-population train/test models; Machine learning; Multitudinal and multimodal data,"COVID-19; algorithm; artificial intelligence; Coronavirus infection; decision making; epidemic; forecasting; health care delivery; human; machine learning; virus pneumonia; Algorithms; Artificial Intelligence; Coronavirus Infections; Decision Making; Delivery of Health Care; Disease Outbreaks; Forecasting; Humans; Machine Learning; Pneumonia, Viral","Wu, F., Zhao, S., Yu, B., Chen, Y.M., Wang, W., Song, Z.G., Hu, Y., Zhang, Y.Z., A new coronavirus associated with human respiratory disease in china (2020) Nature, 44 (59), pp. 265-269; (2020) Public Health Response to the Coronavirus Disease 2019 Outbreak – United States, , February 24; Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Zhang, L., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in wuhan, china: A descriptive study (2020) The Lancet, 395 (10223), pp. 507-513. , http://www.sciencedirect.com/science/article/; (2020) Report, Coronavirus Disease 2019 (COVID-19) Situation Report – 49, , https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200229-sitrep-40-covid-19.pdf?sfvrsn=849d0665_2, accessed March 09, 2020; Wu, Z., McGoogan, J.M., Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: Summary of a report of 72,314 cases from the Chinese center for disease control and prevention (2020) JAMA; (2020) The WHO Declares Public Health Emergency for Novel Coronavirus, , https://www.medscape.com/viewarticle/924596, January 30; Long, J.B., Ehrenfeld, J.M., The role of augmented intelligence (ai) in detecting and preventing the spread of novel coronavirus (2020) Journal of Medical Systems, 44; Paules, C.I., Marston, H.D., Fauci, A.S., Coronavirus infections – more than just the common cold (2020) JAMA, 323 (8), pp. 707-708; Drosten, C., Gunther, S., Identification of a novel corona virus in patients with severe acute respiratory syndrome (2003) N Engl J Med, 348, pp. 1967-1976; Peiris, J., Lai, S., Poon, L., Guan, Y., Yam, L., Lim, W., Nicholls, J., Yuen, K., Coronavirus as a possible cause of severe acute respiratory syndrome (2003) The Lancet, 361 (9366); Song, Z., Xu, Y., Bao, L., Zhang, L., Yu, P., Qu, Y., Zhu, H., Qin, C., From sars to mers, thrusting coronaviruses into the spotlight (2019) Viruses, 11 (1). , https://www.mdpi.com/1999-4915/11/1/59; de Wit, E., van Doremalen, N., Falzarano, D., Munster, V.J., Sarsandmers: Recentinsights into emerging coronaviruses (2016) Nature Reviews Microbiology, 14 (8), pp. 523-534; Sammut, C., Webb, G.I., (2017) Encyclopedia of Machine Learning and Data Mining, , https://doi.org/10.1007/978-1-4899-7687-1, Springer; Chen, J., Wu, L., Zhang, J., Zhang, L., Gong, D., Zhao, Y., Hu, S., Yu, H., (2020) Deep Learning-Based Model for Detecting 2019 Novel Coronavirus Pneumonia on High-Resolution Computed Tomography: A Prospective Study. 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Machine Learning & Cybernetics, 9 (8), pp. 1307-1319; (2020) Technology Org, AI Algorithm Detects Coronavirus Infections in Patients from CT Scans with 96% Accuracy, , https://www.technology.org/2020/03/01/ai-algorithm-detects-coronavirus-infections-in-patients-from-ct-scans-with-96-accuracy/, accessed March 02, 2020; Ai, T., Yang, Z., Hou, H., Zhan, C., Chen, C., Lv, W., Tao, Q., Xia, L., Correlation of chest ct and rt-pcr testing in coronavirus disease 2019 (Covid-19) in china: A report of 1014 cases (2020) Radiology, , https://doi.org/10.1148/radiol.2020200642; Bernheim, A., Mei, X., Huang, M., Yang, Y., Fayad, Z.A., Zhang, N., Diao, K., Chung, M., Chest ct findings in coronavirus disease-19 (Covid-19): Relationship to duration of infection (2020) Radiology, , https://doi.org/10.1148/radiol.2020200463; Fong, S.J., Li, G., Dey, N., Crespo, R.G., Herrera-Viedma, E., Finding an accurate early forecasting model from small dataset: A case of 2019-ncov novel coronavirus outbreak (2020) International Journal of Interactive Multimedia and Artificial Intelligence, 6, pp. 51-61","Santosh, K.C.; Department of Computer Science, University of South Dakota, 414 E Clark St, United States; email: santosh.kc@ieee.org",,Springer,1485598,,JMSYD,32189081,English,J. Med. Syst.,Article,Final,Open Access,Scopus,2-s2.0-85082143057,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Gorse G.J., Donovan M.M., Patel G.B.",57216111335;56742841100;7103119682;,Antibodies to coronaviruses are higher in older compared with younger adults and binding antibodies are more sensitive than neutralizing antibodies in identifying coronavirus-associated illnesses,2020,Journal of Medical Virology,92,5,,512,517,,,10.1002/jmv.25715,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081017634&doi=10.1002%2fjmv.25715&partnerID=40&md5=66482d655e8d5d5b9e25f840e062c906,"Section of Infectious Diseases, and Research and Development Service, VA Saint Louis Health Care System, Saint Louis, MO, United States; Division of Infectious Diseases, Allergy, and Immunology, School of Medicine, Saint Louis University, Saint Louis, MO, United States","Gorse, G.J., Section of Infectious Diseases, and Research and Development Service, VA Saint Louis Health Care System, Saint Louis, MO, United States, Division of Infectious Diseases, Allergy, and Immunology, School of Medicine, Saint Louis University, Saint Louis, MO, United States; Donovan, M.M., Section of Infectious Diseases, and Research and Development Service, VA Saint Louis Health Care System, Saint Louis, MO, United States; Patel, G.B., Section of Infectious Diseases, and Research and Development Service, VA Saint Louis Health Care System, Saint Louis, MO, United States, Division of Infectious Diseases, Allergy, and Immunology, School of Medicine, Saint Louis University, Saint Louis, MO, United States","Human coronaviruses (HCoV) are common causes of respiratory illnesses (RI) despite preexisting humoral immunity. Sera were obtained near the onset of RI and 3 to 4 weeks later as part of a prospective study of 200 subjects evaluated for RI from 2009 to 2013. Antibodies against common HCoV strains were measured by enzyme-linked immunosorbent assay and neutralization assay comparing older adults with cardiopulmonary diseases (99 subjects) to younger, healthy adults (101 subjects). Virus shedding was detected in respiratory secretions by polymerase chain reaction. Of 43 HCoV-associated illnesses, 15 (35%) occurred in 14 older adults (aged ≥60 years) and 28 (65%) in 28 younger adults (aged 21-40 years). Binding and neutralizing antibodies were higher in older adults. Only 16 (35.7%) of RI with increases in binding antibodies also had increases in neutralizing antibodies to HCoV. Increases in binding antibodies with RI were more frequent than increased neutralizing antibodies and virus shedding, and more frequent in younger compared to older adults. Functional neutralizing antibodies were not stimulated as often as binding antibodies, explaining in part a susceptibility to reinfection with HCoV. Monitoring binding antibodies may be more sensitive for the serologic detection of HCoV infections. Published 2020. 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VI. frequency of and relationship between outbreaks of coronavirus infection (1974) J Infect Dis, 129, pp. 271-276; Corapi, W.V., Olsen, C.W., Scott, F.W., Monoclonal antibody analysis of neutralization and antibody-dependent enhancement of feline infectious peritonitis virus (1992) J Virol, 66, pp. 6695-6705; Wang, S.-F., Tseng, S.-P., Yen, C.-H., Antibody-dependent SARS coronavirus infection is mediated by antibodies against spike proteins (2014) Biochem Biophys Res Commun, 451, pp. 208-214; Yip, M.S., Leung, H.L., Li, P.H., Antibody-dependent enhancement of SARS coronavirus infection and its role in the pathogenesis of SARS (2016) Hong Kong Med J, 22 (S 4), pp. 25-31. , S25-31; Gorse, G.J., Patel, G.B., Fan, X., Interpatient mutational spectrum of human coronavirus-OC43 revealed by Illumina sequencing (2017) J Med Virol, 89, pp. 1330-1338","Gorse, G.J.; Section of Infectious Diseases, and Research and Development Service, VA Saint Louis Health Care SystemUnited States; email: gorsegj@slu.edu",,John Wiley and Sons Inc.,1466615,,JMVID,32073157,English,J. Med. Virol.,Article,Final,Open Access,Scopus,2-s2.0-85081017634,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Jalava K.,6603787185;,First respiratory transmitted food borne outbreak?,2020,International Journal of Hygiene and Environmental Health,226,,113490,,,,1,10.1016/j.ijheh.2020.113490,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079663023&doi=10.1016%2fj.ijheh.2020.113490&partnerID=40&md5=480df3d64b4d0d7048e2f91a190db252,"Department of Mathematics and Statistics (Faculty of Social Sciences), University of Helsinki, Finland; Department of Food Hygiene and Environmental Health (Faculty of Veterinary Medicine), University of Helsinki, Finland","Jalava, K., Department of Mathematics and Statistics (Faculty of Social Sciences), University of Helsinki, Finland, Department of Food Hygiene and Environmental Health (Faculty of Veterinary Medicine), University of Helsinki, Finland","The world is faced with a remarkable coronavirus outbreak with epicentre in Wuhan, China. Altogether 40554 cases have been confirmed globally with novel coronavirus (SARS-CoV-2) until February 10, 2020. Rigorous surveillance in other countries is required to prevent further global expansion of the outbreak, but resolving the exact mechanism of the initial transmission events is crucial. Most initial cases had visited Huanan South Seafood Market in Wuhan selling also various exotic live animals. Based on the limited initial human-to-human transmission and timely clustering of cases in Huanan market among elderly men, coupled with knowledge that coronaviruses are derived from animals and relationship of SARS-CoV-2 to bat coronavirus, zoonotic transmission in the first instance is probable. To target the actions, similar epidemiological actions to human cases are needed with animal or food exposures. According to current information, an exceptionally wide contamination of seafood market might explain the initiation of the SARS-CoV-2 outbreak. Seafood tanks, air contamination by live animals or rodents are possibilities, but sold animals normally come from various sources. The mode of transmission may become clearer in future: usually in outbreak investigations, hindsight is easy, but for now information about the initial source of this outbreak is limited. © 2020 Elsevier GmbH",2019-nCoV; COVID-19; SARS-CoV-2,,"Sciencenews, No, snakes probably aren't the source of that new coronavirus in China. 2020 (2020), https://www.sciencenews.org/article/snakes-probably-not-source-spread-new-coronavirus-outbreak-china, (Accessed 10 February 2020); Cohen, J., New coronavirus threat galvanizes scientists (2020) Science, 367 (6477), pp. 492-493. , 31 Jan 2020; Cui, J., Li, F., Shi, Z.L., Origin and evolution of pathogenic coronaviruses (2019) Nat. Rev. Microbiol., 17, pp. 181-192; Grant, R., Malik, M.R., Elkholy, A., Van Kerkhove, M.D., A review of asymptomatic and sub-clinical Middle East respiratory syndrome coronavirus infections (2019) Epidemiol. Rev., , Nov 29, 2019; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Cao, B., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, , S0140-6736(20)30183-30185; Imai, N., Dorigatti, I., Cori, A., Riley, S., Ferguson, N.M., Estimating the potential total number of novel Coronavirus cases in Wuhan City, China http://www.imperial.ac.uk/mrc-global-infectious-disease-analysis/news--wuhan-coronavirus/, (Accessed 10 February 2020); Jalava, K., Kauppinen, A., Al-Hello, H., Räsänen, S., An outbreak of norovirus infection caused by ice cubes and a leaking air ventilation valve (2018) Epidemiol. Infect., pp. 1-6; Ji, W., Wang, W., Zhao, X., Zai, J., Li, X., Homologous recombination within the spike glycoprotein of the newly identified coronavirus may boost cross-species transmission from snake to human (2020) J. Med. Virol.; Keto-Timonen, R., Markkula, A., Halkilahti, J., Huttunen, R., Räsänen, S., Salmenlinna, S., Heikkilä, A., Jalava, K., Shopping detail information and home freezer sampling confirmed the role of commercial, modified-atmosphere packaged meatballs as a vehicle for listeriosis in Finland (2019) Front. Pub. Health, 7 (216); Morgan, O., How decision makers can use quantitative approaches to guide outbreak responses (2019) Philos. Trans. R. Soc. Lond. B Biol. Sci., 374, p. 20180365; Did pangolins spread the China coronavirus to people? (2020), https://www.nature.com/articles/d41586-020-00364-2, (Accessed 10 February 2020); National Health Commission of the People's Republic of China, Epidemic prevention and control dynamics (Chinese). 2020 (2020), http://www.nhc.gov.cn/, (Accessed 10 February 2020); Self, J., Conrad, A., Stroika, S., Jackson, A., Whitlock, L., Jackson, K., Beal, J., Basler, C., Multistate outbreak of listeriosis associated with packaged leafy green salads, United States and Canada, 2015–2016 (2019) Emerg. Infect. Dis., 25 (8); Thompson, R.N., Novel Coronavirus Outbreak in Wuhan, China, 2020: Intense surveillance is vital for preventing sustained transmission in new location (2020) J. Clin. Med., 9 (2), p. 498; Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Wang, B., Peng, Z., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) JAMA, , Feb 7, 2020; World Health Organization, 2019-nCoV situation reports. 2020 (2020), https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports, (Accessed 10 February 2020)",,,Elsevier GmbH,14384639,,IJEHF,,English,Int. J. Hyg. Environ. Health,Note,Final,,Scopus,2-s2.0-85079663023,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Jiang X., Rayner S., Luo M.-H.",57215730900;16550833000;7202891775;,Does SARS-CoV-2 has a longer incubation period than SARS and MERS?,2020,Journal of Medical Virology,92,5,,476,478,,1,10.1002/jmv.25708,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081330940&doi=10.1002%2fjmv.25708&partnerID=40&md5=1d4509fc82bb2474358e33b90307a7a9,"The Joint Center of Translational Precision Medicine Guangzhou Institute of Pediatrics, Guangzhou Women and Children Medical Center, Guangzhou, China; The Joint Center of Translational Precision Medicine, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China; Department of Medical Genetics, Oslo University Hospital and University of Oslo, Oslo, Norway; Hybrid Technology Hub—Centre of Excellence, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway; Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China; State Key Laboratory of Virology, CAS Center for Excellence in Brain Science and Intelligence Technology (CEBSIT), Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China; University of Chinese Academy of Sciences, Beijing, China","Jiang, X., The Joint Center of Translational Precision Medicine Guangzhou Institute of Pediatrics, Guangzhou Women and Children Medical Center, Guangzhou, China, The Joint Center of Translational Precision Medicine, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China; Rayner, S., Department of Medical Genetics, Oslo University Hospital and University of Oslo, Oslo, Norway, Hybrid Technology Hub—Centre of Excellence, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China; Luo, M.-H., The Joint Center of Translational Precision Medicine Guangzhou Institute of Pediatrics, Guangzhou Women and Children Medical Center, Guangzhou, China, The Joint Center of Translational Precision Medicine, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China, State Key Laboratory of Virology, CAS Center for Excellence in Brain Science and Intelligence Technology (CEBSIT), Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China, University of Chinese Academy of Sciences, Beijing, China","The outbreak of a novel coronavirus (SARS-CoV-2) since December 2019 in Wuhan, the major transportation hub in central China, became an emergency of major international concern. While several etiological studies have begun to reveal the specific biological features of this virus, the epidemic characteristics need to be elucidated. Notably, a long incubation time was reported to be associated with SARS-CoV-2 infection, leading to adjustments in screening and control policies. To avoid the risk of virus spread, all potentially exposed subjects are required to be isolated for 14 days, which is the longest predicted incubation time. However, based on our analysis of a larger dataset available so far, we find there is no observable difference between the incubation time for SARS-CoV-2, severe acute respiratory syndrome coronavirus (SARS-CoV), and middle east respiratory syndrome coronavirus (MERS-CoV), highlighting the need for larger and well-annotated datasets. © 2020 Wiley Periodicals, Inc.",coronavirus; incubation; local infection/replication/spread; pandemic; virulence,"China; clinical feature; coronavirus disease 2019; Coronavirus infection; epidemic; incubation time; infection control; infection resistance; infection risk; Middle East respiratory syndrome coronavirus; nonhuman; Note; outcome assessment; SARS coronavirus; screening test; severe acute respiratory syndrome coronavirus 2; species comparison; strain difference; virus isolation; virus transmission; basic reproduction number; Betacoronavirus; human; information processing; Middle East respiratory syndrome coronavirus; pathogenicity; pathology; SARS coronavirus; severe acute respiratory syndrome; time factor; virology; virus pneumonia; COVID-19; severe acute respiratory syndrome coronavirus 2; Basic Reproduction Number; Betacoronavirus; China; Coronavirus Infections; Datasets as Topic; Humans; Infectious Disease Incubation Period; Middle East Respiratory Syndrome Coronavirus; Pneumonia, Viral; SARS Virus; Severe Acute Respiratory Syndrome; Time Factors","Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, , https://doi.org/NEJMoa2001017; Zhou, P., Yang, X.L., Wang, X.G., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) The Lancet, 395 (10223), pp. 497-506; (2020), http://www.nhc.gov.cn/xcs/yqtb/202002/6c305f6d70f545d59548ba17d79b8229.shtml; Munster, V.J., Koopmans, M., van Doremalen, N., van Riel, D., de Wit, E., A novel coronavirus emerging in China—Key questions for impact assessment (2020) N Engl J Med, , https://doi.org/10.1056/NEJMp2000929; Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia N Engl J Med; Lessler, J., Reich, N.G., Brookmeyer, R., Perl, T.M., Nelson, K.E., Cummings, D.A., Incubation periods of acute respiratory viral infections: a systematic review (2009) Lancet Infect Dis, 9 (5), pp. 291-300; Park, J.E., Jung, S., Kim, A., Park, J.E., MERS transmission and risk factors: a systematic review (2018) BMC Public Health, 18 (1), p. 574; Backer, J.A., Klinkenberg, D., Wallinga, J., The incubation period of 2019-nCoV infections among travellers from Wuhan, China (2020) medRxiv, , https://doi.org/10.1101/2020.01.27.20018986; Sun, K., (2020) Online repository, , https://docs.google.com/spreadsheets/d/1jS24DjSPVWa4iuxuD4OAXrE3QeI8c9BC1hSlqrNMiU/edit#gid=1449891965","Luo, M.-H.; The Joint Center of Translational Precision Medicine Guangzhou Institute of Pediatrics, Guangzhou Women and Children Medical CenterChina; email: luomh@wh.iov.cn",,John Wiley and Sons Inc.,1466615,,JMVID,32056235,English,J. Med. Virol.,Note,Final,Open Access,Scopus,2-s2.0-85081330940,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Touret F., de Lamballerie X.",53864283200;7006347976;,Of chloroquine and COVID-19,2020,Antiviral Research,177,,104762,,,,1,10.1016/j.antiviral.2020.104762,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080972220&doi=10.1016%2fj.antiviral.2020.104762&partnerID=40&md5=e61399fca8b3df25f1f7245299ca5572,"Unité des Virus Emergents, UVE: Aix Marseille Univ, IRD 190, INSERM 1207, IHU Méditerranée Infection, Marseille, 13005, France","Touret, F., Unité des Virus Emergents, UVE: Aix Marseille Univ, IRD 190, INSERM 1207, IHU Méditerranée Infection, Marseille, 13005, France; de Lamballerie, X., Unité des Virus Emergents, UVE: Aix Marseille Univ, IRD 190, INSERM 1207, IHU Méditerranée Infection, Marseille, 13005, France","Recent publications have brought attention to the possible benefit of chloroquine, a broadly used antimalarial drug, in the treatment of patients infected by the novel emerged coronavirus (SARS-CoV-2). The scientific community should consider this information in light of previous experiments with chloroquine in the field of antiviral research. © 2020 Elsevier B.V.",2019-nCoV; Antiviral; Chloroquine; COVID-19; SARS-CoV-2,chloroquine; 2019 novel coronovirus; antiviral activity; clinical practice; Coronavirinae; Coronavirus infection; drug efficacy; human; medical research; nonhuman; priority journal; publication; Review; scientist,"Chauhan, A., Tikoo, A., The enigma of the clandestine association between chloroquine and HIV-1 infection (2015) HIV Med., 16, pp. 585-590; Chinese Clinical Trial Register (ChiCTR), The world health organization international clinical trials registered organization registered platform http://www.chictr.org.cn/enIndex.aspx, accessed 3.1.20; Colson, P., Rolain, J.-M., Raoult, D., Chloroquine for the 2019 novel coronavirus SARS-CoV-2 (2020) Int. J. Antimicrob. 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Virol., 83, pp. 1058-1059; Dowall, S.D., Bosworth, A., Watson, R., Bewley, K., Taylor, I., Rayner, E., Hunter, L., Carroll, M.W., Chloroquine inhibited Ebola virus replication in vitro but failed to protect against infection and disease in the in vivo Guinea pig model (2015) J. Gen. Virol., 96, pp. 3484-3492; Falzarano, D., Safronetz, D., Prescott, J., Marzi, A., Feldmann, F., Feldmann, H., Lack of protection against ebola virus from chloroquine in mice and hamsters (2015) Emerg. Infect. Dis., 21, pp. 1065-1067; Frisk-Holmberg, M., Bergqvist, Y., Englund, U., Chloroquine intoxication [letter] (1983) Br. J. Clin. Pharmacol., 15, pp. 502-503; Gao, J., Tian, Z., Yang, X., Breakthrough: chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies (2020) Biosci. Trends; Helal, G.K., Gad, M.A., Abd-Ellah, M.F., Eid, M.S., Hydroxychloroquine augments early virological response to pegylated interferon plus ribavirin in genotype-4 chronic hepatitis C patients (2016) J. Med. Virol., 88, pp. 2170-2178; Inglot, A.D., Comparison of the antiviral activity in vitro of some non-steroidal anti-inflammatory drugs (1969) J. Gen. Virol., 4, pp. 203-214; Katz, S.J., Russell, A.S., Re-evaluation of antimalarials in treating rheumatic diseases: re-appreciation and insights into new mechanisms of action (2011) Curr. Opin. Rheumatol., 23, pp. 278-281; Keyaerts, E., Li, S., Vijgen, L., Rysman, E., Verbeeck, J., Van Ranst, M., Maes, P., Antiviral activity of chloroquine against human coronavirus OC43 infection in newborn mice (2009) Antimicrob. Agents Chemother., 53, pp. 3416-3421; Keyaerts, E., Vijgen, L., Maes, P., Neyts, J., Ranst, M.V., In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine (2004) Biochem. Biophys. Res. Commun., 323, pp. 264-268; Li, C., Zhu, X., Ji, X., Quanquin, N., Deng, Y.-Q., Tian, M., Aliyari, R., Cheng, G., Chloroquine, a FDA-approved drug, prevents Zika virus infection and its associated congenital microcephaly in mice (2017) EBioMedicine, 24, pp. 189-194; Maheshwari, R.K., Srikantan, V., Bhartiya, D., Chloroquine enhances replication of Semliki Forest virus and encephalomyocarditis virus in mice (1991) J. Virol., 65, pp. 992-995; Miller, D.K., Lenard, J., Antihistaminics, local anesthetics, and other amines as antiviral agents (1981) Proc. Natl. Acad. Sci. U.S.A., 78, pp. 3605-3609; Pallister, J., Middleton, D., Crameri, G., Yamada, M., Klein, R., Hancock, T.J., Foord, A., Wang, L.-F., Chloroquine administration does not prevent Nipah virus infection and disease in ferrets (2009) J. Virol., 83, pp. 11979-11982; Paton, N.I., Lee, L., Xu, Y., Ooi, E.E., Cheung, Y.B., Archuleta, S., Wong, G., Smith, A.W., Chloroquine for influenza prevention: a randomised, double-blind, placebo controlled trial (2011) Lancet Infect. Dis., 11, pp. 677-683; Peymani, P., Yeganeh, B., Sabour, S., Geramizadeh, B., Fattahi, M.R., Keyvani, H., Azarpira, N., Lankarani, K.B., New use of an old drug: chloroquine reduces viral and ALT levels in HCV non-responders (a randomized, triple-blind, placebo-controlled pilot trial) (2016) Can. J. Physiol. Pharmacol., 94, pp. 613-619; Roques, P., Thiberville, S.-D., Dupuis-Maguiraga, L., Lum, F.-M., Labadie, K., Martinon, F., Gras, G., Le Grand, R., Paradoxical effect of chloroquine treatment in enhancing chikungunya virus infection (2018) Viruses, 10; Savarino, A., Boelaert, J.R., Cassone, A., Majori, G., Cauda, R., Effects of chloroquine on viral infections: an old drug against today's diseases (2003) Lancet Infect. Dis., 3, pp. 722-727; Seth, P., Mani, H., Singh, A.K., Banaudha, K.K., Madhavan, S., Sidhu, G.S., Gaddipati, J.P., Maheshwari, R.K., Acceleration of viral replication and up-regulation of cytokine levels by antimalarials: implications in malaria-endemic areas (1999) Am. J. Trop. Med. Hyg., 61, pp. 180-186; Shimizu, Y., Yamamoto, S., Homma, M., Ishida, N., Effect of chloroquine on the growth of animal viruses (1972) Arch. Gesamte Virusforsch., 36, pp. 93-104; Tan, Y.W., Yam, W.K., Sun, J., Chu, J.J.H., An evaluation of chloroquine as a broad-acting antiviral against hand, foot and mouth disease (2018) Antivir. Res., 149, pp. 143-149; Tricou, V., Minh, N.N., Van, T.P., Lee, S.J., Farrar, J., Wills, B., Tran, H.T., Simmons, C.P., A randomized controlled trial of chloroquine for the treatment of dengue in Vietnamese adults (2010) PLoS Neglected Trop. Dis., 4, p. e785; Vigerust, D.J., McCullers, J.A., Chloroquine is effective against influenza A virus in vitro but not in vivo. Influenza Other Respir (2007) Viruses, 1, pp. 189-192; Wang, M., Cao, R., Zhang, L., Yang, X., Liu, J., Xu, M., Shi, Z., Xiao, G., Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro (2020) Cell Res., pp. 1-3; Yan, Y., Zou, Z., Sun, Y., Li, X., Xu, K.-F., Wei, Y., Jin, N., Jiang, C., Anti-malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model (2013) Cell Res., 23, pp. 300-302","de Lamballerie, X.; Unité des Virus Emergents, UVE: Aix Marseille Univ, IRD 190, INSERM 1207, IHU Méditerranée InfectionFrance; email: xavier.de-lamballerie@univ-amu.fr",,Elsevier B.V.,1663542,,ARSRD,,English,Antiviral Res.,Review,Final,Open Access,Scopus,2-s2.0-85080972220,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Giovanetti M., Benvenuto D., Angeletti S., Ciccozzi M.",55486066500;57208408457;7003426796;8791594200;,The first two cases of 2019-nCoV in Italy: Where they come from?,2020,Journal of Medical Virology,92,5,,518,521,,3,10.1002/jmv.25699,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079433155&doi=10.1002%2fjmv.25699&partnerID=40&md5=b44d9c3ed1fdb3e573ac3790a052dd4d,"Laboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil; Unit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome, Rome, Italy; Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome, Rome, Italy","Giovanetti, M., Laboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil; Benvenuto, D., Unit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome, Rome, Italy; Angeletti, S., Unit of Clinical Laboratory Science, University Campus Bio-Medico of Rome, Rome, Italy; Ciccozzi, M., Unit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome, Rome, Italy","A novel Coronavirus, 2019-nCoV, has been identified as the causal pathogen of an ongoing epidemic, with the first cases reported in Wuhan, China, last December 2019, and has since spread to other countries worldwide, included Europe and very recently Italy. In this short report, phylogenetic reconstruction was used to better understand the transmission dynamics of the virus from its first introduction in China focusing on the more recent evidence of infection in a couple of Chinese tourists arrived in Italy on 23rd January 2020 and labeled as Coronavirus Italian cases. A maximum clade credibility tree has been built using a dataset of 54 genome sequences of 2019-nCoV plus two closely related bat strains (SARS-like CoV) available in GenBank. Bayesian time-scaled phylogenetic analysis was implemented in BEAST 1.10.4. The Bayesian phylogenetic reconstruction showed that 2019-2020 nCoV firstly introduced in Wuhan on 25 November 2019, started epidemic transmission reaching many countries worldwide, including Europe and Italy where the two strains isolated dated back 19 January 2020, the same that the Chinese tourists arrived in Italy. Strains isolated outside China were intermixed with strains isolated in China as evidence of likely imported cases in Rome, Italy, and Europe, as well. In conclusion, this report suggests that further spread of 2019-nCoV epidemic was supported by human mobility and that quarantine of suspected or diagnosed cases is useful to prevent further transmission. Viral genome phylogenetic analysis represents a useful tool for the evaluation of transmission dynamics and preventive action. © 2020 Wiley Periodicals, Inc.",engineering and technology; epidemiology; infection; macromolecular design,"Article; Bayes theorem; cladistics; Coronavirinae; coronavirus disease 2019; Coronavirus infection; epidemic; gene sequence; genetic distance; infection prevention; Italy; molecular epidemiology; molecular evolution; nonhuman; phylogeny; population dispersal; SARS-related coronavirus; sequence alignment; Severe acute respiratory syndrome coronavirus 2; virus genome; virus identification; virus isolation; virus strain; virus transmission; animal; bat; Betacoronavirus; biological model; Coronavirus infection; genetics; human; interatrial block; isolation and purification; Italy; mutation rate; pandemic; virology; virus genome; virus pneumonia; COVID-19; severe acute respiratory syndrome coronavirus 2; Animals; Betacoronavirus; Chiroptera; Coronavirus Infections; Genome, Viral; Humans; Interatrial Block; Italy; Models, Genetic; Mutation Rate; Pandemics; Phylogeny; Pneumonia, Viral","Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, , https://doi.org/10.1056/NEJMoa2001017; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, , https://doi.org/10.1016/S0140-6736(20)30183-5; Hui, D.S., I Azhar, E., Madani, T.A., The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health–the latest 2019 novel coronavirus outbreak in Wuhan, China (2020) Int J Infect Dis, 91, pp. 264-266; Benvenuto, D., Giovannetti, M., Ciccozzi, A., Spoto, S., Angeletti, S., Ciccozzi, M., The 2019-new coronavirus epidemic: evidence for virus evolution (2020) J Med Virol, , https://doi.org/10.1002/jmv.25688; Katoh, K., Rozewicki, J., Yamada, K.D., MAFFT online service: multiple sequence alignment, interactive sequence choice and visualization (2019) Brief Bioinform, 20 (4), pp. 1160-1166. , https://doi.org/10.1093/bib/bbx108; Hall, T.A., BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT (1999) Nucleic Acids Symp Ser, 41, pp. 95-98; Darriba, D., Taboada, G.L., Doallo, R., Posada, D., jModelTest 2: more models, new heuristics and parallel computing (2012) Nat Methods, 9 (8), p. 772; Rambaut, A., Lam, T.T., Max Carvalho, L., Pybus, O.G., Exploring the temporal structure of heterochronous sequences using TempEst (formerly Path-O-Gen) (2016) Virus Evol, 2 (1); Suchard, M.A., Lemey, P., Baele, G., Ayres, D.L., Drummond, A.J., Rambaut, A., Bayesian phylogenetic and phylodynamic data integration using BEAST 1.10 (2018) Virus Evol, 4 (1); Baele, G., Li, W.L., Drummond, A.J., Suchard, M.A., Lemey, P., Accurate model selection of relaxed molecular clocks in bayesian phylogenetics (2013) Mol Biol Evol, 30 (2), pp. 239-243; Drummond, A.J., Ho, S.Y., Phillips, M.J., Rambaut, A., Relaxed phylogenetics and dating with confidence (2006) PLoS Biol, 4 (5); Rambaut, A., Drummond, A.J., Xie, D., Baele, G., Suchard, M.A., Posterior summarization in Bayesian phylogenetics using Tracer 1.7 (2018) Syst Biol, 67 (5), pp. 901-904; Emerging understandings of 2019-nCoV (2020) Lancet, 395 (10221), p. 311. , https://doi.org/10.1016/S0140-6736(20)30186-0","Angeletti, S.; Unit of Clinical Laboratory Science, University Campus Bio-Medico of RomeItaly; email: s.angeletti@unicampus.it",,John Wiley and Sons Inc.,1466615,,JMVID,32022275,English,J. Med. Virol.,Article,Final,Open Access,Scopus,2-s2.0-85079433155,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Long C., Xu H., Shen Q., Zhang X., Fan B., Wang C., Zeng B., Li Z., Li X., Li H.",56112086300;57215860081;55221040400;56113285200;57215081757;57215836653;57215835058;57215831720;57215972563;57215971572;,Diagnosis of the Coronavirus disease (COVID-19): rRT-PCR or CT?,2020,European Journal of Radiology,126,,108961,,,,,10.1016/j.ejrad.2020.108961,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082451101&doi=10.1016%2fj.ejrad.2020.108961&partnerID=40&md5=06bf42382acc12377e0eef79abbe197c,"Radiology Department, Jiangxi Provincial People's Hospital, Nanchang, 330006, China; Radiology Department, Yichang Yiling Hospital, Yichang, 443100, China; Medical Cosmetology Department, Jiangxi Provincial People's Hospital, Nanchang, 330006, China; Institute of Clinical Medicine, Jiangxi Provincial People's Hospital, Nanchang, 330006, China","Long, C., Radiology Department, Yichang Yiling Hospital, Yichang, 443100, China; Xu, H., Medical Cosmetology Department, Jiangxi Provincial People's Hospital, Nanchang, 330006, China; Shen, Q., Institute of Clinical Medicine, Jiangxi Provincial People's Hospital, Nanchang, 330006, China; Zhang, X., Radiology Department, Yichang Yiling Hospital, Yichang, 443100, China; Fan, B., Radiology Department, Jiangxi Provincial People's Hospital, Nanchang, 330006, China; Wang, C., Radiology Department, Jiangxi Provincial People's Hospital, Nanchang, 330006, China; Zeng, B., Radiology Department, Jiangxi Provincial People's Hospital, Nanchang, 330006, China; Li, Z., Radiology Department, Jiangxi Provincial People's Hospital, Nanchang, 330006, China; Li, X., Radiology Department, Jiangxi Provincial People's Hospital, Nanchang, 330006, China; Li, H., Radiology Department, Jiangxi Provincial People's Hospital, Nanchang, 330006, China","Purpose: To evaluate the diagnostic value of computed tomography (CT) and real-time reverse-transcriptase-polymerase chain reaction (rRT-PCR) for COVID-19 pneumonia. Methods: This retrospective study included all patients with COVID-19 pneumonia suspicion, who were examined by both CT and rRT-PCR at initial presentation. The sensitivities of both tests were then compared. For patients with a final confirmed diagnosis, clinical and laboratory data, in addition to CT imaging findings were evaluated. Results: A total of 36 patients were finally diagnosed with COVID-19 pneumonia. Thirty-five patients had abnormal CT findings at presentation, whereas one patient had a normal CT. Using rRT-PCR, 30 patients were tested positive, with 6 cases initially missed. Amongst these 6 patients, 3 became positive in the second rRT-PCR assay(after 2 days, 2 days and 3 days respectively), and the other 3 became positive only in the third round of rRT-PCR tests(after 5 days, 6 days and 8 days respectively). At presentation, CT sensitivity was therefore 97.2%, whereas the sensitivity of initial rRT-PCR was only 83.3%. Conclusion: rRT-PCR may produce initial false negative results. We suggest that patients with typical CT findings but negative rRT-PCR results should be isolated, and rRT-PCR should be repeated to avoid misdiagnosis. © 2020 Elsevier B.V.",Coronavirus; Pneumonia; Severe Acute Respiratory Syndrome; Tomography; X-Ray Computed,adult; Article; China; clinical article; computer assisted tomography; controlled study; coronavirus disease 2019; Coronavirus infection; diagnostic error; diagnostic test accuracy study; diagnostic value; false negative result; female; human; intermethod comparison; laboratory test; male; pneumonia; priority journal; real time reverse transcription polymerase chain reaction; retrospective study; sensitivity analysis,"Zhu, N., Zhang, D., Wang, W., A Novel Coronavirus from Patients with Pneumonia in China, 2019 (2020) N Engl J Med; Chung, M., Bernheim, A., Mei, X., CT Imaging Features of 2019 Novel Coronavirus (2019-nCoV) (2020) Radiology; Pan, Y., Guan, H., Imaging changes in patients with 2019-nCov (2020) Eur Radiol.; Corman, V.M., Landt, O., Kaiser, M., Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR (2020) Euro Surveill., 25 (3); Rubin, E.J., Baden, L.R., Morrissey, S., Campion, E.W., Medical Journals and the 2019-nCoV Outbreak (2020) N Engl J Med.; Lancet, T., Emerging understandings of 2019-nCoV (2020) Lancet, 395 (10221), p. 311; Lu, H., Stratton, C.W., Tang, Y.W., Outbreak of Pneumonia of Unknown Etiology in Wuhan China: the Mystery and the Miracle (2020) J Med Virol.; Gralinski, L.E., Menachery, V.D., Return of the Coronavirus: 2019-nCoV (2020) Viruses, 12 (2); Duarte, R., Furtado, I., Sousa, L., Carvalho, C.F.A., The 2019 Novel Coronavirus (2019-nCoV): Novel Virus, Old Challenges (2020) Acta Med Port.; Wang, M., Cao, R., Zhang, L., Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro (2020) Cell Res.; Lin, X., Gong, Z., Xiao, Z., Novel Coronavirus Pneumonia Outbreak in 2019: Computed Tomographic Findings in Two Cases (2020) Korean J Radiol; Carlos, W.G., Dela CCS, C.B., Pasnick, S., Jamil, S., Novel Wuhan (2019-nCoV) Coronavirus (2020) Am J Respir Crit Care Med.; Liu, W., Morse, J.S., Lalonde, T., Xu, S., Learning from the Past: Possible Urgent Prevention and Treatment Options for Severe Acute Respiratory Infections Caused by 2019-nCoV (2020) Chembiochem.; Team, E.E., Note from the editors: World Health Organization declares novel coronavirus (2019-nCoV) sixth public health emergency of international concern (2020) Euro Surveill; Team, E.E., Note from the editors: novel coronavirus (2019-nCoV) (2020) Euro Surveill, 25 (3); Tian, H.Y., 2019-nCoV: new challenges from coronavirus (2020) Zhonghua Yu Fang Yi Xue Za Zhi, 54, p. E001; Li, X., Zai, J., Wang, X., Li, Y., Potential of large’ first generation’ human-to-human transmission of 2019-nCoV (2020) J Med Virol.; Zhao, S., Lin, Q., Ran, J., Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: A data-driven analysis in the early phase of the outbreak (2020) Int J Infect Dis.; Zhang, N., Wang, L., Deng, X., Recent advances in the detection of respiratory virus infection in humans (2020) J Med Virol.; Lei, J., Li, J., Li, X., Qi, X., CT Imaging of the 2019 Novel Coronavirus (2019-nCoV) Pneumonia (2020) Radiology; Kanne, J.P., Chest CT Findings in 2019 Novel Coronavirus (2019-nCoV) Infections from Wuhan, China: Key Points for the Radiologist (2020) Radiology; Song, F., Shi, N., Shan, F., Emerging Coronavirus 2019-nCoV Pneumonia (2020) Radiology","Fan, B.; Radiology Department, Jiangxi Provincial People's HospitalChina; email: 26171381@qq.com",,Elsevier Ireland Ltd,0720048X,,EJRAD,,English,Eur. J. Radiol.,Article,Final,,Scopus,2-s2.0-85082451101,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Chughtai A.A., Seale H., Islam M.S., Owais M., Macintyre C.R.",55511253500;23104390500;57215826995;57215836093;57203198705;,Policies on the use of respiratory protection for hospital health workers to protect from coronavirus disease (COVID-19),2020,International Journal of Nursing Studies,105,,103567,,,,,10.1016/j.ijnurstu.2020.103567,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081993103&doi=10.1016%2fj.ijnurstu.2020.103567&partnerID=40&md5=afd9b080eb83cfacaa7292353f709581,"School of Public Health and Community Medicine, UNSW Medicine, University of New South Wales, Samuels Building, Kensington, NSW 2052, Australia; Biosecurity Program, The Kirby Institute, The University of New South Wales, Sydney, Kensington 2052, NSW, Australia, College of Public Service & Community Solutions, Arizona State University, Tempe, AZ, United States","Chughtai, A.A., School of Public Health and Community Medicine, UNSW Medicine, University of New South Wales, Samuels Building, Kensington, NSW 2052, Australia; Seale, H., School of Public Health and Community Medicine, UNSW Medicine, University of New South Wales, Samuels Building, Kensington, NSW 2052, Australia; Islam, M.S., School of Public Health and Community Medicine, UNSW Medicine, University of New South Wales, Samuels Building, Kensington, NSW 2052, Australia; Owais, M., School of Public Health and Community Medicine, UNSW Medicine, University of New South Wales, Samuels Building, Kensington, NSW 2052, Australia; Macintyre, C.R., Biosecurity Program, The Kirby Institute, The University of New South Wales, Sydney, Kensington 2052, NSW, Australia, College of Public Service & Community Solutions, Arizona State University, Tempe, AZ, United States",[No abstract available],,,"Aiello, A.E., Coulborn, R.M., Aragon, T.J., Baker, M.G., Burrus, B.B., Cowling, B.J., Research findings from nonpharmaceutical intervention studies for pandemic influenza and current gaps in the research (2010) Am. J. Infect. Control, 38 (4), pp. 251-258; Aiello, A.E., Perez, V., Coulborn, R.M., Davis, B.M., Uddin, M., Monto, A.S., Facemasks, hand hygiene, and influenza among young adults: a randomized intervention trial (2012) PLoS One, 7 (1), p. e29744; Aiello, A.E., Murray, G.F., Perez, V., Coulborn, R.M., Davis, B.M., Uddin, M., Mask use, hand hygiene, and seasonal influenza-like illness among young adults: a randomized intervention trial (2010) J. Infect. Dis., 201 (4), pp. 491-498; Aledort, J.E., Lurie, N., Wasserman, J., Bozzette, S.A., Non-pharmaceutical public health interventions for pandemic influenza: an evaluation of the evidence base (2007) BMC Public Health, 7, p. 208; Beckman, S., Materna, B., Goldmacher, S., Zipprich, J., D'Alessandro, M., Novak, D., Evaluation of respiratory protection programs and practices in California hospitals during the 2009-2010 H1N1 influenza pandemic (2013) Am. J. Infect. Control, 41 (11), pp. 1024-1031; Bell, D., Nicoll, A., Fukuda, K., Horby, P., Monto, A., Hayden, F., Non-pharmaceutical interventions for pandemic influenza, national and community measures (2006) Emerging Infect. Dis., 12 (1), pp. 88-94; https://www.canada.ca/en/public-health/services/diseases/2019-novel-coronavirus-infection/health-professionals.html#i, Government of Canada. Coronavirus Disease (COVID-19): For health Professionals [Available from:; Canini, L., Andreoletti, L., Ferrari, P., D'Angelo, R., Blanchon, T., Lemaitre, M., Surgical mask to prevent influenza transmission in households: a cluster randomized trial (2010) PLoS One, 5 (11), p. e13998; Interim Healthcare Infection Prevention and Control Recommendations For Patients Under Investigation for 2019 Novel Coronavirus (2020), https://www.cdc.gov/coronavirus/2019-nCoV/infection-control.html, January 2020[Available from:; Questions and Answers Regarding Respiratory Protection For Preventing 2009 H1N1 Influenza Among Healthcare Personnel (2014), http://www.cdc.gov/h1n1flu/guidelines_infection_control_qa.htm#ex_use, [Available from:; Recommended Guidance for Extended Use and Limited Reuse of N95 Filtering Facepiece Respirators in Healthcare Settings (2014), http://www.cdc.gov/niosh/topics/hcwcontrols/recommendedguidanceextuse.html, [Available from:; New Coronavirus Pneumonia Prevention and Control Plan (2020), http://www.nhc.gov.cn/jkj/s3577/202002/573340613ab243b3a7f61df260551dd4.shtml, 4th Edition [Available from:; Chughtai, A.A., Seale, H., MacIntyre, C.R., Availability, consistency and evidence-base of policies and guidelines on the use of mask and respirator to protect hospital health care workers: a global analysis (2013) BMC Res. Notes, 6, p. 216; Chughtai, A.A., MacIntyre, C.R., Peng, Y., Wang, Q., Ashraf, M.O., Dung, T.C., Practices around the use of masks and respirators among hospital health care workers in 3 diverse populations (2015) Am. J. Infect. Control, 43, pp. 1116-1118; Chughtai, A.A., Stelzer-Braid, S., Rawlinson, W., Pontivivo, G., Wang, Q., Pan, Y., Contamination by respiratory viruses on outer surface of medical masks used by hospital healthcare workers (2019) BMC Infect. Dis., 19 (1), p. 491; https://www1.health.gov.au/internet/main/publishing.nsf/Content/cdna-song-novel-coronavirus.htm, Communicable Diseases Network Australia (CDNA). CDNA National Guidelines For Public Health Units [Available from:; Cowling, B.J., Chan, K.H., Fang, V.J., Cheng, C.K., Fung, R.O., Wai, W., Facemasks and hand hygiene to prevent influenza transmission in households: a cluster randomized trial (2009) Ann. Intern. Med., 151 (7), pp. 437-446; Infection Prevention and Control For the Care of Patients With 2019-nCoV in Healthcare Settings (2020), https://www.ecdc.europa.eu/sites/default/files/documents/nove-coronavirus-infection-prevention-control-patients-healthcare-settings.pdf, [Available from:; European Directive. Guidelines On the Application of Council Directive 89/686/EEC of 21 December 1989 On the Approximation of the Laws of the Member states Relating to Personal Protective Equipment; Gunaratnam, P.J., Tobin, S., Seale, H., Marich, A., McAnulty, J., Airport arrivals screening during pandemic (H1N1) 2009 influenza in new south wales, Australia (2014) Med. J. Aust., 200 (5), pp. 290-292; Reusability of Facemasks During an Influenza Pandemic: Facing the Flu (2006); Preventing Transmission of Pandemic Influenza and Other Viral Respiratory Diseases: Personal Protective Equipment for Healthcare Personnel Update 2010 (2010), The National Academies Press Washington D.C; Johnson, D.F., Druce, J.D., Birch, C., Grayson, M.L., A quantitative assessment of the efficacy of surgical and N95 masks to filter influenza virus in patients with acute influenza infection (2009) Clin. Infect. Dis. Off. Publ. Infect. Dis. Soc. Am., 49 (2), pp. 275-277; Lautenbach, E., Saint, S., Henderson, D.K., Harris, A.D., Initial response of health care institutions to emergence of H1N1 influenza: experiences, obstacles, and perceived future needs (2010) Clin. Infect. Dis. Off. Publ. Infect. Dis. Soc. Am., 50 (4), pp. 523-527; MacIntyre, C.R., Chughtai, A.A., Seale, H., Richards, G.A., Davidson, P.M., Respiratory protection for healthcare workers treating ebola virus disease (EVD): are facemasks sufficient to meet occupational health and safety obligations? (2014) Int. J. Nurs. Stud., 51 (11), pp. 1421-1426; MacIntyre, C.R., Chughtai, A.A., Seale, H., Richards, G.A., Davidson, P.M., Uncertainty, risk analysis and change for ebola personal protective equipment guidelines (2014) Int. J. Nurs. Stud., 52 (5), pp. 899-903; MacIntyre, C.R., Cauchemez, S., Dwyer, D.E., Seale, H., Cheung, P., Browne, G., Face mask use and control of respiratory virus transmission in households (2009) Emerg. Infect. Dis., 15 (2), pp. 233-241; MacIntyre, C.R., Zhang, Y., Chughtai, A.A., Seale, H., Zhang, D., Chu, Y., Cluster randomised controlled trial to examine medical mask use as source control for people with respiratory illness (2016) BMJ Open, 6 (12); McKinney, K.R., Gong, Y.Y., Lewis, T.G., Environmental transmission of SARS at amoy gardens (2006) J. Environ. Health, 68 (9), pp. 26-30. , quiz 51-2; NIOSH Guide to the Selection and Use of Particulate Respirators (1995); (2009), Occupational Safety and Health Administration (OSHA). U.S. department of labor. Pandemic Influenza Preparedness and Response Guidance for HealthcareWorkers and Healthcare Employers; Occupational Safety and Health Administration (OSHA). U.S. department of labor. respiratory protection. OSHA 3079. 2002 (Revised); https://www.gov.uk/government/publications/wuhan-novel-coronavirus-infection-prevention-and-control/wuhan-novel-coronavirus-wn-cov-infection-prevention-and-control-guidance, Public Health England. Guidance. COVID-19: Infection Prevention and Control Guidance [Available from:; Rebmann, T., Wagner, W., Infection preventionists' experience during the first months of the 2009 novel H1N1 influenza a pandemic (2009) Am. J. Infect. Control, 37 (10), pp. e5-e16; Shenal, B.V., Radonovich, L.J., Jr., Cheng, J., Hodgson, M., Bender, B.S., Discomfort and exertion associated with prolonged wear of respiratory protection in a health care setting (2012) J. Occup. Environ. Hyg., 9 (1), pp. 59-64; Simmerman, J.M., Suntarattiwong, P., Levy, J., Jarman, R.G., Kaewchana, S., Gibbons, R.V., Findings from a household randomized controlled trial of hand washing and face masks to reduce influenza transmission in Bangkok, Thailand (2011) Influenza Other Respir Viruses, 5 (4), pp. 256-267; Pandemic Influenza – phase 6 infection Control Recommendations Template (2006), http://www.sonoma-county.org/health/topics/pdf/infectioncontrol/phase6icrecommendations.pdf, [Available from:; (2012), Standards Australia Limited/Standards New Zealand. Respiratory protective devices. Australian/New Zealand Standard. AS/NZS 1716:; Suess, T., Remschmidt, C., Schink, S.B., Schweiger, B., Nitsche, A., Schroeder, K., The role of facemasks and hand hygiene in the prevention of influenza transmission in households: results from a cluster randomised trial; Berlin, Germany, 2009–2011 (2012) BMC Infect. Dis., 12, p. 26; Tomizuka, T., Kanatani, Y., Kawahara, K., Insufficient preparedness of primary care practices for pandemic influenza and the effect of a preparedness plan in japan: a prefecture-wide cross-sectional study (2013) BMC Fam. Pract., 14, p. 174; Viscusi, D.J., Bergman, M.S., Eimer, B.C., Shaffer, R.E., Evaluation of five decontamination methods for filtering facepiece respirators (2009) Ann. Occup. Hyg., 53 (8), pp. 815-827; Novel Coronavirus (2019-nCoV) Situation Reports (2020), https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports, Available from:; Infection Prevention and Control of Epidemic- and Pandemic-Prone Acute Respiratory Infections in Health Care (2014); https://www.who.int/publications-detail/infection-prevention-and-control-during-health-care-when-novel-coronavirus-(ncov)-infection-is-suspected, World Health Organisation (WHO). Infection prevention and control during health care when novel coronavirus (nCoV) infection is suspected. Interim guidance 2020 [Available from:; Novel Coronavirus (2019-nCoV) (2020), https://www.who.int/westernpacific/emergencies/novel-coronavirus, [Available from:; Zhang, W., Du, R.-H., Li, B., Zheng, X.-S., Yang, X.-L., Hu, B., Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes (2020) Emerg. Microbes Infect., 9 (1), pp. 386-389","Chughtai, A.A.; School of Public Health and Community Medicine, UNSW Medicine, University of New South Wales, Samuels Building, Australia; email: abrar.chughtai@unsw.edu.au",,Elsevier Ltd,207489,,IJNUA,,English,Int. J. Nurs. Stud.,Editorial,Final,Open Access,Scopus,2-s2.0-85081993103,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Yang C., Li C., Wang S., National Clinical Research Center for Child Health and Disorders and Children's Oncology Committee of Chinese Research Hospital Association",57208589954;57195950821;57213427308;,Clinical strategies for treating pediatric cancer during the outbreak of 2019 novel coronavirus infection,2020,Pediatric Blood and Cancer,67,5, e28248,,,,,10.1002/pbc.28248,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081203829&doi=10.1002%2fpbc.28248&partnerID=40&md5=32dffb1e1718d0e0d0568d92ad575835,"Department of Surgical Oncology, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China","Yang, C., Department of Surgical Oncology, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China; Li, C., Department of Surgical Oncology, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China; Wang, S., Department of Surgical Oncology, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, 400014, China; National Clinical Research Center for Child Health and Disorders and Children's Oncology Committee of Chinese Research Hospital Association",[No abstract available],,,"Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382, pp. 727-733","Li, C.; Department of Surgical Oncology, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical UniversityChina; email: surgli@163.com",,John Wiley and Sons Inc.,15455009,,PBCEA,32147944,English,Pediatr. Blood Cancer,Letter,Final,Open Access,Scopus,2-s2.0-85081203829,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Han W., Quan B., Guo Y., Zhang J., Lu Y., Feng G., Wu Q., Fang F., Cheng L., Jiao N., Li X., Chen Q.",57209735806;57209735485;57215502502;57209737145;57215495793;57215494305;57215491554;57215500135;57215492231;36113678600;56874984700;57209740746;,The course of clinical diagnosis and treatment of a case infected with coronavirus disease 2019,2020,Journal of Medical Virology,92,5,,461,463,,2,10.1002/jmv.25711,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080978164&doi=10.1002%2fjmv.25711&partnerID=40&md5=ffdb871b4f30df2b876c7d89293be74e,"Department of Clinical Laboratory, The First Affiliated Hospital of Wanan Medical College, Wuhu, Anhui, China; Department of Infectious Diseases, The First Affiliated Hospital of Wanan Medical College, Wuhu, Anhui, China; Department of Gynaecology and Obstetrics, The First Affiliated Hospital of Wanan Medical College, Wuhu, Anhui, China; Department of Clinical Blood Laboratory, The First Affiliated Hospital of Wanan Medical College, Wuhu, Anhui, China; Department of Medical Laboratory Science, School of Laboratory Medicine, Wanan Medical College, Wuhu, Anhui, China; Department of Pathology, The First Affiliated Hospital of Wanan Medical College, Wuhu, Anhui, China; Department of Nuclear Medicine, The First Affiliated Hospital of Wanan Medical College, Wuhu, Anhui, China","Han, W., Department of Clinical Laboratory, The First Affiliated Hospital of Wanan Medical College, Wuhu, Anhui, China; Quan, B., Department of Infectious Diseases, The First Affiliated Hospital of Wanan Medical College, Wuhu, Anhui, China; Guo, Y., Department of Gynaecology and Obstetrics, The First Affiliated Hospital of Wanan Medical College, Wuhu, Anhui, China; Zhang, J., Department of Clinical Blood Laboratory, The First Affiliated Hospital of Wanan Medical College, Wuhu, Anhui, China; Lu, Y., Department of Medical Laboratory Science, School of Laboratory Medicine, Wanan Medical College, Wuhu, Anhui, China; Feng, G., Department of Clinical Laboratory, The First Affiliated Hospital of Wanan Medical College, Wuhu, Anhui, China; Wu, Q., Department of Clinical Laboratory, The First Affiliated Hospital of Wanan Medical College, Wuhu, Anhui, China; Fang, F., Department of Clinical Laboratory, The First Affiliated Hospital of Wanan Medical College, Wuhu, Anhui, China; Cheng, L., Department of Clinical Laboratory, The First Affiliated Hospital of Wanan Medical College, Wuhu, Anhui, China; Jiao, N., Department of Pathology, The First Affiliated Hospital of Wanan Medical College, Wuhu, Anhui, China; Li, X., Department of Clinical Laboratory, The First Affiliated Hospital of Wanan Medical College, Wuhu, Anhui, China; Chen, Q., Department of Nuclear Medicine, The First Affiliated Hospital of Wanan Medical College, Wuhu, Anhui, China",[No abstract available],COVID-19; lopinavir and ritonavir tablets; SARS-CoV-2; severe respiratory syndrome,China; Coronavirus infection; human; Middle East respiratory syndrome coronavirus; pneumonia; China; Coronavirus Infections; Humans; Middle East Respiratory Syndrome Coronavirus; Pneumonia,"Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, 382, pp. 727-733; Chan, J.F.W., Yuan, S., Kok, K.H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, 395, pp. 514-523. , January 24 (Epub ahead of print); Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395, pp. 507-513. , January 29 (Epub ahead of print); Wang, D., Hu, B., Hu, C., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) JAMA, , https://doi.org/10.1001/jama.2020.1585; https://www.cdc.gov/coronavirus/2019-nCoV/guidelines-clinical-specimens.html, Interim guidelines for collecting, handlingtesting clinical specimens from patients under investigation (PUIs) for 2019 novel coronavirus (2019-nCoV). 2020; Corman, V.M., Landt, O., Kaiser, M., (2020) Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR. Euro Surveill, 25 (3). , https://doi.org/10.2807/1560-7917.ES.2020.25.3.2000045; Guan, W., Ni, Z., Hu, Y., Clinical characteristics of 2019 novel coronavirus infection in China (2020) MedRxiv, , https://doi.org/10.1101/2020.02.06.20020974","Li, X.; Department of Clinical Laboratory, The First Affiliated Hospital of Wanan Medical CollegeChina; email: lixiaoning19702006@126.com",,John Wiley and Sons Inc.,1466615,,JMVID,32073161,English,J. Med. Virol.,Letter,Final,Open Access,Scopus,2-s2.0-85080978164,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wang G., Jin X.",57215197026;57215196627;,The progress of 2019 novel coronavirus event in China,2020,Journal of Medical Virology,92,5,,468,472,,1,10.1002/jmv.25705,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080027813&doi=10.1002%2fjmv.25705&partnerID=40&md5=4511866391fd49e2c6685324694f54a9,"Department of Social Medicine and Health Management, School of Public Health, Hangzhou Medical College, Hangzhou, Zhejiang, China; Department of Economics and Management, Jinhua Polytechnics, Jinhua, Zhejiang, China","Wang, G., Department of Social Medicine and Health Management, School of Public Health, Hangzhou Medical College, Hangzhou, Zhejiang, China; Jin, X., Department of Economics and Management, Jinhua Polytechnics, Jinhua, Zhejiang, China",[No abstract available],,China; coronavirus disease 2019; human; nonhuman; Note; SARS coronavirus; severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; trend study,"(2020) Prevention and control of novel coronavirus infected pneumonia, , http://www.nhc.gov.cn, Accessed 11 February; (2020) Epidemic situation of 2019-nCoV pneumonia in Hubei Province on Feb. 10th, , http://wjw.hubei.gov.cn/, Accessed 11 February 2020; Mahase, E., China coronavirus: what do we know so far? (2020) BMJ, 368; Zhou, P., Yang, X.L., Wang, X.G., Discovery of a novel coronavirus associated with the recent pneumonia outbreak in humans and its potential bat origin (2020) bioRxiv, , https://doi.org/10.1101/2020.01.22.914952, Available from, https://www.biorxiv.org/content/10.1101/2020.01.22.914952v2; Overview of 2019 novel coronavirus (2019-nCoV) (2020) BMJ, , https://bestpractice.bmj.com/topics/en-gb/3000165, Accessed 9 February; Catharine, I.P., Hilary, D.M., Anthony, S.F., Coronavirus infections—more than just the common cold (2020) JAMA, , https://doi.org/10.1001/jama.2020.0757, Available from, https://jamanetwork.com/journals/jama/fullarticle/2759815; Wu, J.T., Leung, K., Leung, G.M., Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study (2020) Lancet, , https://doi.org/10.1016/S0140-6736(20)30260-9, Available from, https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30260-9/fulltext; Kickbusch, I., Leung, G., Response to the emerging novel coronavirus outbreak (2020) BMJ, 368; http://www.satcm.gov.cn, Diagnosis and treatment of novel coronavirus infected pneumonia (The fifth edition)., Accessed 9 February 2020; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395, pp. 507-513. , https://doi.org/10.1016/S0140-6736(20)30211-7; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506. , https://doi.org/10.1016/S0140-6736(20)30183-5; Chan, J.F.W., Yuan, S., Kok, K.H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, 395, pp. 514-523. , https://doi.org/10.1016/S0140-6736(20)30154-9; Zhang, H., Kang, Z., Gong, H., The digestive system is a potential route of 2019-nCov infection: a bioinformatics analysis based on single-cell transcriptomes (2020) bioRxiv, , https://doi.org/10.1101/2020.01.30.927806, Available from, https://www.biorxiv.org/content/10.1101/2020.01.30.927806v1; Riou, J., Althaus, C.L., Pattern of early human-to-human transmission of Wuhan 2019 novel coronavirus (2019-nCoV), December 2019 to January 2020 (2020) Euro Surveill, 25 (4). , https://doi.org/10.2807/1560-7917.ES.2020.25.4.2000058, Available from, https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2020.25.4.2000058; Zhaohui Tong, the Critical Care Medicine expert: The biggest difference between SARS-nCoV and 2019-nCoV, , https://www.thepaper.cn/newsDetail_forward_5641344, Accessed 9 February 2020; Munster, V.J., Koopmans, M., van Doremalen, N., van Riel, D., de Wit, E., A novel coronavirus emerging in China—key questions for impact assessment (2020) N Engl J Med, , https://doi.org/10.1056/NEJMp2000929, Available from, https://www.nejm.org/doi/full/10.1056/NEJMp2000929; Health topics: Coronavirus, , https://www.who.int/health-topics/coronavirus, Accessed 9 February 2020; https://www.who.int/news-room/detail/30-01-2020-statement-on-the-second-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-outbreak-of-novel-coronavirus-(2019-ncov, Newsroom, detail., Accessed 9 February 2020; A neonatal has been confirmed with 2019-nCoV pneumonia 30 hours after birth in Wuhan, , https://www.thepaper.cn/newsDetail_forward_5798570, Accessed 9 February 2020; Wang, W., Tang, J., Wei, F., Updated understanding of the outbreak of 2019 novel coronavirus (2019-nCoV) in Wuhan, China (2020) J Med Virol, , https://doi.org/10.1002/jmv.25689, Available from, https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.25689; Nkengasong, J., China's response to a novel coronavirus stands in a stark contrast to the 2002 SARS outbreak response (2020) Nat Med, , https://doi.org/10.1038/s41591-020-0771-1, Available from, https://www.nature.com/articles/s41591-020-0771-1; http://www.gov.cn, Accessed 9 February 2020; https://baijiahao.baidu.com/s?id=1656612972558028424&wfr=spider&for=pc, The national health commission sent medical staffs to support Wuhan city., Accessed 9 February 2020; http://nmdc.cn/#/nCoV, Accessed 9 February 2020; https://bigd.big.ac.cn/?lang=zh, Accessed 9 February 2020; http://www.chinacdc.cn/jkzt/crb/zl/szkb_11803/, Accessed 9 February 2020; https://wxn.qq.com/cmsid/20200128A096A500, Challenges are remaining with the development of novel coronavirus. At least six research teams around the world are racing against time., Accessed 9 February 2020; Hui, D.S., Azhar, E., Madani, T.A., The continuing 2019-nCoV epidemic treat of novel coronaviruses to global health—the latest 2019 novel coronavirus outbreak in Wuhan, China (2020) Int J Infect Dis, 91, pp. 264-266","Wang, G.; Department of Social Medicine and Health Management, School of Public Health, Hangzhou Medical CollegeChina; email: wangguanhz@163.com",,John Wiley and Sons Inc.,1466615,,JMVID,32048741,English,J. Med. Virol.,Note,Final,Open Access,Scopus,2-s2.0-85080027813,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Xiao S.-Y., Wu Y., Liu H.",13310234300;57215024735;57205385074;,Evolving status of the 2019 novel coronavirus infection: Proposal of conventional serologic assays for disease diagnosis and infection monitoring,2020,Journal of Medical Virology,92,5,,464,467,,1,10.1002/jmv.25702,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079709025&doi=10.1002%2fjmv.25702&partnerID=40&md5=f45fbfdae1d3f70b8a36a00856d47b09,"Department of Pathology, Wuhan University Zhongnan Hospital, Wuhan University Center for Pathology and Molecular Diagnostics, Wuhan, China; Department of Pathology, University of Chicago Medicine, Chicago, IL, United States","Xiao, S.-Y., Department of Pathology, Wuhan University Zhongnan Hospital, Wuhan University Center for Pathology and Molecular Diagnostics, Wuhan, China, Department of Pathology, University of Chicago Medicine, Chicago, IL, United States; Wu, Y., Department of Pathology, Wuhan University Zhongnan Hospital, Wuhan University Center for Pathology and Molecular Diagnostics, Wuhan, China; Liu, H., Department of Pathology, Wuhan University Zhongnan Hospital, Wuhan University Center for Pathology and Molecular Diagnostics, Wuhan, China",[No abstract available],,severe acute respiratory syndrome coronavirus 2; animal; bat; Betacoronavirus; Coronavirinae; Coronavirus infection; epidemic; pneumonia; Animals; Betacoronavirus; Chiroptera; Coronavirus; Coronavirus Infections; Disease Outbreaks; Pneumonia,"Chan, J.F.W., Yuan, S., Kok, K.H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, , https://doi.org/10.1016/S0140-6736(20)30154-9; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, (20), pp. 30183-30185. , https://doi.org/10.1016/S0140-6736(20)30183-5; Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N Engl J Med, , https://doi.org/10.1056/NEJMoa2001017; Zhou, P., Yang, X.-L., Wang, X.-G., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature, , https://doi.org/10.1038/s41586-020-2012-7; Tan, W., Zhao, X., Ma, X., A novel coronavirus genome identified in a cluster of pneumonia cases-Wuhan, China 2019−2020[J] (2020) China CDC Weekly, 2 (4), pp. 61-62. , http://weekly.chinacdc.cn/en/article/id/a3907201-f64f-4154-a19e-4253b453d10c; Office of State Administration of Traditional Chinese Medicine Notice on the issuance of strategic guidelines for diagnosis and treatment of novel coronavirus (2019-nCoV) infected pneumonia (fourth edition draft) (2020-01-28) [EB/OL], , http://bgs.satcm.gov.cn/zhengcewenjian/2020-01-28/12576.html; Update on the epidemic of novel coronavirus (2019-nCoV) infected pneumonia (2020-01-26) [EB/OL], , http://www.nhc.gov.cn/xcs/yqtb/202001/3882fdcdbfdc4b4fa4e3a829b62d518e.shtml; Louie, J.K., Hacker, J.K., Mark, J., SARS and common viral infections (2004) Emerging Infect Dis, 10 (6), pp. 1143-1146; Woo, P.C.Y., Lau, S.K.P., Wong, B.H.L., Detection of specific antibodies to severe acute respiratory syndrome (SARS) coronavirus nucleocapsid protein for serodiagnosis of SARS coronavirus pneumonia (2004) J Clin Microbiol, 42 (5), pp. 2306-2309; Xiao, S.Y., Zhu, B.L., Zhang, M.Y., Zhang, T.M., Zheng, Z.M., Hsiang, C.M., A sequential study of serum specific IgM antibody responses in EHF and their relationship to the severity of illness (1986) Chin J Immunol, 2, pp. 218-221; Xiao, S.-Y., Zhu, B.-L., Zhang, M., Effect of ribavirin on the specific humoral immune responses of patients with hemorrhagic fever with renal syndrome (1987) Chin J Virol, 3, pp. 243-247","Xiao, S.-Y.; Department of Pathology, Wuhan University Zhongnan Hospital, Wuhan University Center for Pathology and Molecular DiagnosticsChina; email: syxiao@uchicago.edu",,John Wiley and Sons Inc.,1466615,,JMVID,32031264,English,J. Med. Virol.,Note,Final,Open Access,Scopus,2-s2.0-85079709025,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Baruah V., Bose S.",57209540583;16512277600;,Immunoinformatics-aided identification of T cell and B cell epitopes in the surface glycoprotein of 2019-nCoV,2020,Journal of Medical Virology,92,5,,495,500,,1,10.1002/jmv.25698,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080975858&doi=10.1002%2fjmv.25698&partnerID=40&md5=0fdd2ca574e7fa6ca16b73e6dbbcb641,"Department of Biotechnology, Gauhati University, Guwahati, Assam, India","Baruah, V., Department of Biotechnology, Gauhati University, Guwahati, Assam, India; Bose, S., Department of Biotechnology, Gauhati University, Guwahati, Assam, India","The 2019 novel coronavirus (2019-nCoV) outbreak has caused a large number of deaths with thousands of confirmed cases worldwide, especially in East Asia. This study took an immunoinformatics approach to identify significant cytotoxic T lymphocyte (CTL) and B cell epitopes in the 2019-nCoV surface glycoprotein. Also, interactions between identified CTL epitopes and their corresponding major histocompatibility complex (MHC) class I supertype representatives prevalent in China were studied by molecular dynamics simulations. We identified five CTL epitopes, three sequential B cell epitopes and five discontinuous B cell epitopes in the viral surface glycoprotein. Also, during simulations, the CTL epitopes were observed to be binding MHC class I peptide-binding grooves via multiple contacts, with continuous hydrogen bonds and salt bridge anchors, indicating their potential in generating immune responses. Some of these identified epitopes can be potential candidates for the development of 2019-nCoV vaccines. © 2020 Wiley Periodicals, Inc.",2019-nCoV; coronavirus; COVID-19; epitope prediction; immunoinformatics; SARS-CoV-2,"COVID-19; epitope; HLA antigen class 1; severe acute respiratory syndrome coronavirus 2; virus envelope protein; Betacoronavirus; biology; China; Coronavirus infection; human; immunology; molecular dynamics; protein tertiary structure; virus pneumonia; Betacoronavirus; China; Computational Biology; Coronavirus Infections; Epitopes, B-Lymphocyte; Epitopes, T-Lymphocyte; Histocompatibility Antigens Class I; Humans; Molecular Dynamics Simulation; Pneumonia, Viral; Protein Structure, Tertiary; Viral Envelope Proteins","Novel coronavirus (2019-nCoV) situation report-7, , https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200127-sitrep-7-2019--ncov.pdf, Report 2020; Li, F., Structure, function, and evolution of coronavirus spike proteins (2016) Annual Review of Virology, 3, pp. 237-261. , https://doi.org/10.1146/annurev-virology-110615-042301; 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Saha, S., Raghava, G.P.S., Prediction of continuous B-cell epitopes in an antigen using recurrent neural network (2006) Proteins: Struct, Funct, Bioinf, 65, pp. 40-48. , https://doi.org/10.1002/prot.21078; Ponomarenko, J., Bui, H.-H., Li, W., ElliPro: a new structure-based tool for the prediction of antibody epitopes (2008) BMC Bioinformatics, 9, p. 514. , https://doi.org/10.1186/1471-2105-9-514; Källberg, M., Wang, H., Wang, S., Template-based protein structure modeling using the RaptorX web server (2012) Nat Protoc, 7, pp. 1511-1522. , https://doi.org/10.1038/nprot.2012.085; Lovell, S.C., Davis, I.W., Arendall, W.B., Structure validation by Cα geometry: ϕ, ψ, and Cβ deviation (2003) Proteins: Struct, Funct, Bioinf, 50, pp. 437-450. , https://doi.org/10.1002/prot.10286; Doytchinova, I.A., Flower, D.R., VaxiJen: a server for prediction of protective antigens, tumour antigens, and subunit vaccines (2007) BMC Bioinformatics, 8, p. 8. , https://doi.org/10.1186/1471-2105-8-4; Sievers, F., Wilm, A., Dineen, D., Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega (2011) Mol Syst Biol, 7, p. 539. , https://doi.org/10.1038/msb.2011.75; Ji, W., Niu, L., Peng, W., Salt bridge-forming residues positioned over viral peptides presented by MHC class I impacts T-cell recognition in a binding-dependent manner (2019) Mol Immunol, 112, pp. 274-282. , https://doi.org/10.1016/j.molimm.2019.06.005; Wieczorek, M., Abualrous, E.T., Sticht, J., Major histocompatibility complex (MHC) class I and MHC class II proteins: conformational plasticity in antigen presentation (2017) Front Immunol, 8, p. 8. , https://doi.org/10.3389/fimmu.2017.00292; Rognan, D., Zimmermann, N., Jung, G., Folkers, G., Molecular dynamics study of a complex between the human histocompatibility antigen HLA-A2 and the IMP58-66 nonapeptide from influenza virus matrix protein (1992) Eur J Biochem, 208, pp. 101-113. , https://doi.org/10.1111/j.1432-1033.1992.tb17163.x; Qamar, M.T.U., Saleem, S., Ashfaq, U.A., Bari, A., Anwar, F., Alqahtani, S., Epitope-based peptide vaccine design and target site depiction against Middle East respiratory syndrome coronavirus: an immune-informatics study (2019) J Transl Med, 17, p. 362. , https://doi.org/10.1186/s12967-019-2116-8; Huang, J., Cao, Y., Bu, X., Wu, C., Residue analysis of a CTL epitope of SARS-CoV spike protein by IFN-gamma production and bioinformatics prediction (2012) BMC Immunol, 13, p. 50. , https://doi.org/10.1186/1471-2172-13-50; Guest, J.D., Pierce, B.G., Computational modeling of hepatitis C virus envelope glycoprotein structure and recognition (2018) Front Immunol, 9. , https://doi.org/10.3389/fimmu.2018.01117; Fernando, B.-G., Yersin, C.-T., José, C.-B., Paola, Z.-S., Predicted 3D model of the rabies virus glycoprotein trimer (2016) BioMed Res Int, 2016, pp. 1-11. , https://doi.org/10.1155/2016/1674580; Salemi, M., Fitch, W.M., Ciccozzi, M., Ruiz-Alvarez, M.J., Rezza, G., Lewis, M.J., Severe acute respiratory syndrome coronavirus sequence characteristics and evolutionary rate estimate from maximum likelihood analysis (2004) J Virol, 78, pp. 1602-1603. , https://doi.org/10.1128/jvi.78.3.1602-1603.2004","Baruah, V.; Department of Biotechnology, Gauhati UniversityIndia; email: vargabbarua@gauhati.ac.in",,John Wiley and Sons Inc.,1466615,,JMVID,32022276,English,J. Med. Virol.,Article,Final,Open Access,Scopus,2-s2.0-85080975858,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Elfiky A.A.,37067188100;,"Anti-HCV, nucleotide inhibitors, repurposing against COVID-19",2020,Life Sciences,248,,117477,,,,,10.1016/j.lfs.2020.117477,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080998230&doi=10.1016%2fj.lfs.2020.117477&partnerID=40&md5=05ce39491b2be7c5eaf0502aa2add368,"Biophysics Department, Faculty of Sciences, Cairo University, Giza, Egypt; College of Applied Medical Sciences, University of Al-Jouf, Saudi Arabia","Elfiky, A.A., Biophysics Department, Faculty of Sciences, Cairo University, Giza, Egypt, College of Applied Medical Sciences, University of Al-Jouf, Saudi Arabia","Aims: A newly emerged Human Coronavirus (HCoV) is reported two months ago in Wuhan, China (COVID-19). Until today >2700 deaths from the 80,000 confirmed cases reported mainly in China and 40 other countries. Human to human transmission is confirmed for COVID-19 by China a month ago. Based on the World Health Organization (WHO) reports, SARS HCoV is responsible for >8000 cases with confirmed 774 deaths. Additionally, MERS HCoV is responsible for 858 deaths out of about 2500 reported cases. The current study aims to test anti-HCV drugs against COVID-19 RNA dependent RNA polymerase (RdRp). Materials and methods: In this study, sequence analysis, modeling, and docking are used to build a model for Wuhan COVID-19 RdRp. Additionally, the newly emerged Wuhan HCoV RdRp model is targeted by anti-polymerase drugs, including the approved drugs Sofosbuvir and Ribavirin. Key findings: The results suggest the effectiveness of Sofosbuvir, IDX-184, Ribavirin, and Remidisvir as potent drugs against the newly emerged HCoV disease. Significance: The present study presents a perfect model for COVID-19 RdRp enabling its testing in silico against anti-polymerase drugs. Besides, the study presents some drugs that previously proved its efficiency against the newly emerged viral infection. © 2020 Elsevier Inc.",COVID-19; Docking; Nucleotide inhibitors; RdRp; Sofosbuvir; Structural bioinformatics; Wuhan coronavirus,"antivirus agent; guanosine triphosphate; hepatitis C antibody; idx 184; remidisvir; ribavirin; RNA directed RNA polymerase; sofosbuvir; unclassified drug; adenosine phosphate; alanine; antivirus agent; guanosine phosphate; idx 184; protein binding; remdesivir; ribavirin; RNA directed RNA polymerase; sofosbuvir; uridine triphosphate; viral protein; Article; binding affinity; China; computer model; controlled study; coronavirus disease 2019; coronavirus disease 2019; Coronavirus infection; drug efficacy; drug repositioning; drug structure; enzyme active site; human; Middle East respiratory syndrome coronavirus; molecular docking; nonhuman; SARS coronavirus; sequence alignment; sequence analysis; structural bioinformatics; virus transmission; alpha helix; Alphacoronavirus; amino acid sequence; beta sheet; Betacoronavirus; biology; chemistry; Coronavirus infection; drug repositioning; enzymology; genetics; metabolism; procedures; protein domain; sequence homology; thermodynamics; virology; virus pneumonia; Adenosine Monophosphate; Alanine; Alphacoronavirus; Amino Acid Sequence; Antiviral Agents; Betacoronavirus; Catalytic Domain; Computational Biology; Coronavirus Infections; Drug Repositioning; Guanosine Monophosphate; Guanosine Triphosphate; Humans; Molecular Docking Simulation; Pneumonia, Viral; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Ribavirin; RNA Replicase; Sequence Alignment; Sequence Homology, Amino Acid; Sofosbuvir; Thermodynamics; Uridine Triphosphate; Viral Proteins","Bogoch, I.I., Watts, A., Thomas-Bachli, A., Huber, C., Kraemer, M.U.G., Khan, K., Pneumonia of unknown etiology in Wuhan, China: potential for international spread via commercial air travel (2020) Journal of Travel Medicine; Hui, D.S., Azhar, I.E., Madani, T.A., Ntoumi, F., Kock, R., Dar, O., The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health—the latest 2019 novel coronavirus outbreak in Wuhan, China (2020) International Journal of Infectious Diseases, 91, pp. 264-266; Organization WH, Surveillance Case Definitions for Human Infection With Novel Coronavirus (nCoV): Interim Guidance v1, January 2020 (2020), World Health Organization; Organization WH, Infection Prevention and Control during Health Care When Novel Coronavirus (nCoV) Infection Is Suspected: Interim Guidance, January 2020 (2020), World Health Organization; Organization WH, Laboratory Testing of Human Suspected Cases of Novel Coronavirus (nCoV) Infection: Interim Guidance, 10 January 2020 (2020), World Health Organization; Parr, J., Pneumonia in China: Lack of Information Raises Concerns Among Hong Kong Health Workers (2020), British Medical Journal Publishing Group; Elfiky, A.A.I., N. 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Seminars in Liver Disease (1999), pp. 17-24; Manns, M.P., McHutchison, J.G., Gordon, S.C., Rustgi, V.K., Shiffman, M., Reindollar, R., Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial (2001) Lancet, 358, pp. 958-965; Warren, T.K., Jordan, R., Lo, M.K., Ray, A.S., Mackman, R.L., Soloveva, V., Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys (2016) Nature., 531, pp. 381-385; Salentin, S., Schreiber, S., Haupt, V.J., Adasme, M.F., Schroeder, M., PLIP: fully automated protein–ligand interaction profiler (2015) Nucleic Acids Res., 43; Becke, A.D., Density-functional thermochemistry. III. The role of exact exchange (1993) J. Chem. Phys., 98, pp. 5648-5652; Leach, A., Molecular Modelling: Principles and Applications (2001), 2nd edition Prentice Hall; Stewart, J.J.P., Optimization of parameters for semiempirical methods V: modification of NDDO approximations and application to 70 elements (2007) J. Mol. Model., 13, pp. 1173-1213; Morris, G.M., Huey, R., Lindstrom, W., Sanner, M.F., Belew, R.K., Goodsell, D.S., AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility (2009) J. Comput. Chem., 30, pp. 2785-2791; Ibrahim, I., Abdelmalek, D., Elshahat, M., Elfiky, A., COVID-19 Spike-host cell receptor GRP78 binding site prediction (2020) J. Infect., , In press","Elfiky, A.A.; Biophysics Department, Faculty of Sciences, Cairo UniversityEgypt; email: abdo@sci.cu.edu.eg",,Elsevier Inc.,243205,,LIFSA,32119961,English,Life Sci.,Article,Final,Open Access,Scopus,2-s2.0-85080998230,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Liu K., Chen Y., Wu D., Lin R., Wang Z., Pan L.",57215695573;57215693063;57215693921;57215699696;57215699870;57215683016;,Effects of progressive muscle relaxation on anxiety and sleep quality in patients with COVID-19,2020,Complementary Therapies in Clinical Practice,39,,101132,,,,,10.1016/j.ctcp.2020.101132,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081701936&doi=10.1016%2fj.ctcp.2020.101132&partnerID=40&md5=762312b9e87881622d441aff316e9153,"Department of Health Care Center, Hainan Hospital of Hainan Medical College (Hainan General Hospital), Haikou, China; Department of Clinical Laboratory, Hainan Hospital of Hainan Medical College (Hainan General Hospital), Haikou, China; Department of General Practice, Hainan Hospital of Hainan Medical College (Hainan General Hospital), Haikou, China","Liu, K., Department of Health Care Center, Hainan Hospital of Hainan Medical College (Hainan General Hospital), Haikou, China; Chen, Y., Department of Clinical Laboratory, Hainan Hospital of Hainan Medical College (Hainan General Hospital), Haikou, China; Wu, D., Department of Health Care Center, Hainan Hospital of Hainan Medical College (Hainan General Hospital), Haikou, China; Lin, R., Department of General Practice, Hainan Hospital of Hainan Medical College (Hainan General Hospital), Haikou, China; Wang, Z., Department of General Practice, Hainan Hospital of Hainan Medical College (Hainan General Hospital), Haikou, China; Pan, L., Department of General Practice, Hainan Hospital of Hainan Medical College (Hainan General Hospital), Haikou, China","Background: Patients with Coronavirus Disease 2019(COVID-19) will experience high levels of anxiety and low sleep quality due to isolation treatment. Some sleep-improving drugs may inhibit the respiratory system and worsen the condition. Prolonged bedside instruction may increase the risk of medical infections. Objective: To investigate the effect of progressive muscle relaxation on anxiety and sleep quality of COVID-19. Methods: In this randomized controlled clinical trial, a total of 51 patients who entered the isolation ward were included in the study and randomly divided into experimental and control groups. The experimental group used progressive muscle relaxation (PMR) technology for 30 min per day for 5 consecutive days. During this period, the control group received only routine care and treatment. Before and after the intervention, the Spielberger State-Trait Anxiety Scale (STAI) and Sleep State Self-Rating Scale (SRSS) were used to measure and record patient anxiety and sleep quality. Finally, data analysis was performed using SPSS 25.0 software. Results: The average anxiety score (STAI) before intervention was not statistically significant (P = 0.730), and the average anxiety score after intervention was statistically significant (P < 0.001). The average sleep quality score (SRSS) of the two groups before intervention was not statistically significant (P = 0.838), and it was statistically significant after intervention (P < 0.001). Conclusion: Progressive muscle relaxation as an auxiliary method can reduce anxiety and improve sleep quality in patients with COVID-19. © 2020 The Authors",Anxiety; COVID-19; Progressive muscle relaxation; Sleep quality,,"Lu, H., Stratton, C.W., Tang, Y.W., Outbreak of pneumonia of unknown etiology in Wuhan China: the mystery and the miracle (2020) J Med Virol, , published online Jan 16; Rajeswari, S., SanjeevaReddy, N., Efficacy of progressive muscle relaxation on pregnancy outcome among anxious Indian primi mothers (2019) Iran. J. Nurs. Midwifery Res., 25, pp. 23-30; Cougle, J.R., Wilver, N.L., Day, T.N., Interpretation bias modification versus progressive muscle relaxation for social anxiety disorder: a web-based controlled trial (2020) Behav. Ther., 51, pp. 99-112; Aksu, N.T., Erdogan, A., Ozgur, N., Effects of progressive muscle relaxation training on sleep and quality of life in patients with pulmonary resection (2018) Sleep Breath., 22, pp. 695-702; Wilczyńska, D., Łysak-Radomska, A., Podczarska-Głowacka, M., Evaluation of the effectiveness of relaxation in lowering the level of anxiety in young adults - a pilot study (2019) Int. J. Occup. Med. Environ. Health, 32, pp. 817-824; Rajeswari, S., SanjeevaReddy, N., Efficacy of progressive muscle relaxation on pregnancy outcome among anxious Indian primi mothers (2019) Iran. J. Nurs. Midwifery Res., 25, pp. 23-30; Gok Metin, Z., Karadas, C., Izgu, N., Effects of progressive muscle relaxation and mindfulness meditation on fatigue, coping styles, and quality of life in early breast cancer patients: an assessor blinded, three-arm, randomized controlled trial (2019) Eur. J. Oncol. Nurs., 42, pp. 116-125; Xie, L.Q., Deng, Y.L., Zhang, J.P., Effects of progressive muscle relaxation intervention in extremity fracture surgery patients (2016) West. J. Nurs. Res., 38, pp. 155-168; Seyedi Chegeni, P., Gholami, M., Azargoon, A., The effect of progressive muscle relaxation on the management of fatigue and quality of sleep in patients with chronic obstructive pulmonary disease: a randomized controlled clinical trial (2018) Compl. Ther. Clin. Pract., 31, pp. 64-70; Ferendiuk, E., Biegańska, J.M., Kazana, P., Progressive muscle relaxation according to Jacobson in treatment of the patients with temporomandibular joint disorders (2019) Folia Med. Cracov., 59, pp. 113-122; Masih, T., Dimmock, J.A., Guelfi, K.J., The effect of a single, brief practice of progressive muscle relaxation after exposure to an acute stressor on subsequent energy intake (2019) Stress Health, 35, pp. 595-606; Hasanpour-Dehkordi, A., Solati, K., Tali, S.S., Effect of progressive muscle relaxation with analgesic on anxiety status and pain in surgical patients (2019) Br. J. Nurs., 28, pp. 174-178","Liu, K.; Department of Health Care Center, Hainan Hospital of Hainan Medical College (Hainan General Hospital)China; email: hmliukai@163.com",,Churchill Livingstone,17443881,,,,English,Complement. Ther. Clin. Pract.,Article,Final,Open Access,Scopus,2-s2.0-85081701936,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Fanelli D., Piazza F.",6701746493;35300547700;,"Analysis and forecast of COVID-19 spreading in China, Italy and France",2020,"Chaos, Solitons and Fractals",134,,109761,,,,,10.1016/j.chaos.2020.109761,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082017750&doi=10.1016%2fj.chaos.2020.109761&partnerID=40&md5=c17c6be5f3e6136f9f983dc7ffd412bc,"Dipartimento di Fisica e Astronomia, Universitá di Firenze, INFN and CSDC, Via Sansone 1, Sesto Fiorentino, Firenze 50019, Italy; Centre de Biophysique Moléculaire (CBM), CNRS-UPR 4301, Rue C. Sadron, Orléans, 45071, France; Université d'Orléans, Chéteau de la Source, Orléans Cedex, 45071, France","Fanelli, D., Dipartimento di Fisica e Astronomia, Universitá di Firenze, INFN and CSDC, Via Sansone 1, Sesto Fiorentino, Firenze 50019, Italy; Piazza, F., Centre de Biophysique Moléculaire (CBM), CNRS-UPR 4301, Rue C. Sadron, Orléans, 45071, France, Université d'Orléans, Chéteau de la Source, Orléans Cedex, 45071, France","In this note we analyze the temporal dynamics of the coronavirus disease 2019 outbreak in China, Italy and France in the time window 22/01−15/03/2020. A first analysis of simple day-lag maps points to some universality in the epidemic spreading, suggesting that simple mean-field models can be meaningfully used to gather a quantitative picture of the epidemic spreading, and notably the height and time of the peak of confirmed infected individuals. The analysis of the same data within a simple susceptible-infected-recovered-deaths model indicates that the kinetic parameter that describes the rate of recovery seems to be the same, irrespective of the country, while the infection and death rates appear to be more variable. The model places the peak in Italy around March 21st 2020, with a peak number of infected individuals of about 26000 (not including recovered and dead) and a number of deaths at the end of the epidemics of about 18,000. Since the confirmed cases are believed to be between 10 and 20% of the real number of individuals who eventually get infected, the apparent mortality rate of COVID-19 falls between 4% and 8% in Italy, while it appears substantially lower, between 1% and 3% in China. Based on our calculations, we estimate that 2500 ventilation units should represent a fair figure for the peak requirement to be considered by health authorities in Italy for their strategic planning. Finally, a simulation of the effects of drastic containment measures on the outbreak in Italy indicates that a reduction of the infection rate indeed causes a quench of the epidemic peak. However, it is also seen that the infection rate needs to be cut down drastically and quickly to observe an appreciable decrease of the epidemic peak and mortality rate. This appears only possible through a concerted and disciplined, albeit painful, effort of the population as a whole. © 2020 Elsevier Ltd",Covid-19; epidemic spreading; non linear fitting; population model,Epidemiology; Mean field theory; Recovery; Covid-19; Epidemic spreading; Infection rates; Mean field models; Mortality rate; Nonlinear fitting; Population model; Temporal dynamics; Population statistics,"Dong, E., Du, H., Gardner, L., An interactive web-based dashboard to track COVID-19 in real time (2020) Lancet Infect Dis, 3099 (20), pp. 19-20; https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports/; Storn, R., Price, K., Differential evolution - A simple and efficient heuristic for global optimization over continuous spaces (1997) J Global Optim, 11 (4), pp. 341-359; Guan, W.-J., Ni, Z.-Y., Hu, Y., Liang, W.-H., Ou, C.-Q., He, J.-X., Clinical characteristics of coronavirus disease 2019 in china. (2020) N Eng J Med","Fanelli, D.; Dipartimento di Fisica e Astronomia, Universitá di Firenze, INFN and CSDC, Via Sansone 1, Italy; email: Duccio.Fanelli@unifi.it",,Elsevier Ltd,9600779,,CSFOE,,English,Chaos Solitons Fractals,Article,Final,Open Access,Scopus,2-s2.0-85082017750,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhong Q., Li Z., Shen X., Xu K., Shen Y., Fang Q., Chen F., Liang T.",57215894614;57215893112;55809254400;57215893367;57215865887;57215865654;57215895133;57215866183;,CT imaging features of patients with different clinical types of coronavirus disease 2019 (COVID-19),2020,Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences,49,1,,0,,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082282623&partnerID=40&md5=e8209b4ab7ca8cf3753ebc0f8c0285bf,"Department of Radiology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China; Department of Radiology, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, 310007, China; Department of Infectious Diseases, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China; Department of Respiratory Medicine, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China; Intensive Care Unit, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China; Department of Hepatopancreatobiliary Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China","Zhong, Q., Department of Radiology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China, Department of Radiology, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, 310007, China; Li, Z., Department of Radiology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China; Shen, X., Department of Radiology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China; Xu, K., Department of Infectious Diseases, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China; Shen, Y., Department of Respiratory Medicine, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China; Fang, Q., Intensive Care Unit, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China; Chen, F., Department of Radiology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China; Liang, T., Department of Hepatopancreatobiliary Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China","OBJECTIVE: To analyze the CT findings of patients with different clinical types of coronavirus disease 2019 (COVID-19). METHODS: A total of 67 patients diagnosed as COVID-19 by nucleic acid testing were included and divided into 4 groups according to the clinical staging based on Diagnosis and treatment of novel coronavirus pneumonia (Trial version 6). The CT imaging characteristics were analyzed among patients with different clinical types. RESULTS: Among 67 patients, 3 (4.5%) were mild cases, 35 (52.2%) were ordinary cases, 22 (32.8%) were severe cases, and 7 (10.4%) were critically ill. There were no abnormal CT findings in mild cases. In 35 ordinary cases, there were single lesions in 3 cases (8.6%) and multiple lesions in 33 cases (91.4%), while in severe case 1 case had single lesion (4.5%) and 21 had multiple lesions (95.5%). CT images of ordinary patients were mainly manifested as solid plaque shadow and halo sign (18/35, 51.4%); while fibrous strip shadow with ground glass shadow was more frequent in severe cases (7/22, 31.8%). Consolidation shadow as the main lesion was observed in 7 cases, and all of them were severe or critical ill patients. CONCLUSIONS: CT images in patients with different clinical types of COVID-19 have characteristic manifestations, and solid shadow may predict severe and critical illness.",,"Betacoronavirus; Coronavirus infection; diagnostic imaging; human; lung; pathology; procedures; severity of illness index; virus pneumonia; x-ray computed tomography; Betacoronavirus; Coronavirus Infections; Humans; Lung; Pneumonia, Viral; Severity of Illness Index; Tomography, X-Ray Computed",,,,NLM (Medline),10089292,,,32207591,Chinese,Zhejiang Da Xue Xue Bao Yi Xue Ban,Article,Final,,Scopus,2-s2.0-85082282623,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Li Y., Hu Y., Zhang X., Yu Y., Li B., Wu J., Wu Y., Xia X., Xu J.",57216039833;57216036669;57216042600;57216035970;57216038009;57216042391;57216040068;57216035955;57216041486;,Follow-up testing of viral nucleic acid in discharged patients with moderate type of 2019 coronavirus disease (COVID-19),2020,Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences,49,1,,0,,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082519882&partnerID=40&md5=6ec562a591bc4d5e8bb6f4da4cd8a96f,"Clinical Laboratory, Fourth Affiliated Hospital, Zhejiang University School of Medicine, China; Department of Gynecology and Obstetrics, Fourth Affiliated Hospital, Zhejiang University School of Medicine, China; Department of Infection Diseases, Fourth Affiliated Hospital, Zhejiang University School of Medicine, China","Li, Y., Clinical Laboratory, Fourth Affiliated Hospital, Zhejiang University School of Medicine, China; Hu, Y., Department of Gynecology and Obstetrics, Fourth Affiliated Hospital, Zhejiang University School of Medicine, China; Zhang, X., Clinical Laboratory, Fourth Affiliated Hospital, Zhejiang University School of Medicine, China; Yu, Y., Department of Gynecology and Obstetrics, Fourth Affiliated Hospital, Zhejiang University School of Medicine, China; Li, B., Department of Infection Diseases, Fourth Affiliated Hospital, Zhejiang University School of Medicine, China; Wu, J., Clinical Laboratory, Fourth Affiliated Hospital, Zhejiang University School of Medicine, China; Wu, Y., Clinical Laboratory, Fourth Affiliated Hospital, Zhejiang University School of Medicine, China; Xia, X., Clinical Laboratory, Fourth Affiliated Hospital, Zhejiang University School of Medicine, China; Xu, J., Department of Gynecology and Obstetrics, Fourth Affiliated Hospital, Zhejiang University School of Medicine, China","OBJECTIVE: To investigate the clinical outcome of patients with moderate type of corona virus disease 2019 (COVID-19) after discharge by retesting viral nucleic acid. METHODS: Seven patients with moderate COVID-19 met the discharge criteria enacted by National Health Commission were quarantine in hospital for 7 days, then continuously quarantined at home for 4 weeks after discharged. During the three weeks of quarantined period, the symptoms and signs were documented; and sputum or nasal swab and feces samples were collected to test SARS-COV-2 nucleic acid by RT-PCR method. RESULTS: There were no symptoms and signs during the quarantine period in all 7 patients. However, respiratory swabs from 3 patients were confirmed positive of SARS-COV-2 nucleic acid at 5 to 7 days after they met the discharge criteria. CONCLUSIONS: The study indicates that there is a relatively high incidence of positive viral nucleic acid in patients met the discharge criteria, and it is suggested that patients met the current discharge criteria should be quarantined in hospital for another 7 days and the follow-up viral testing is necessary.",,,,,,NLM (Medline),10089292,,,32222122,Chinese,Zhejiang Da Xue Xue Bao Yi Xue Ban,Article,Final,,Scopus,2-s2.0-85082519882,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Kang X., Zhang R., He H., Yao Y., Zheng Y., Wen X., Zhu S.",57215924470;57215924383;57215924375;57215923931;57215923543;57215924774;7404392147;,Anesthesia management in cesarean section for a patient with coronavirus disease 2019,2020,Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences,49,1,,0,,,,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082380010&partnerID=40&md5=08f764ce656ca8d03b0321ffd8cd87bc,"Department of Anesthesiology, First Affiliated Hospital, College of Medicine, Zhejiang University School of Medicine, Hangzhou, 310003, China","Kang, X., Department of Anesthesiology, First Affiliated Hospital, College of Medicine, Zhejiang University School of Medicine, Hangzhou, 310003, China; Zhang, R., Department of Anesthesiology, First Affiliated Hospital, College of Medicine, Zhejiang University School of Medicine, Hangzhou, 310003, China; He, H., Department of Anesthesiology, First Affiliated Hospital, College of Medicine, Zhejiang University School of Medicine, Hangzhou, 310003, China; Yao, Y., Department of Anesthesiology, First Affiliated Hospital, College of Medicine, Zhejiang University School of Medicine, Hangzhou, 310003, China; Zheng, Y., Department of Anesthesiology, First Affiliated Hospital, College of Medicine, Zhejiang University School of Medicine, Hangzhou, 310003, China; Wen, X., Department of Anesthesiology, First Affiliated Hospital, College of Medicine, Zhejiang University School of Medicine, Hangzhou, 310003, China; Zhu, S., Department of Anesthesiology, First Affiliated Hospital, College of Medicine, Zhejiang University School of Medicine, Hangzhou, 310003, China","Since the corona virus disease 2019 (COVID-19) affects the cardio-pulmonary function of pregnant women, the anesthetic management in the cesarean section for the patients, as well as the protection for medical staff is significantly different from that in ordinary surgical operation. This paper reports a pregnant woman with COVID-19, for whom a cesarean section was successfully performed in our hospital on February 8, 2020. Anesthetic management, protection of medical staff and psychological intervention for the patients during the operation are discussed. Importance should be attached to the preoperative evaluation of pregnant women with COVID-19 and the implementation of anesthesia plan. For ordinary COVID-19 patients intraspinal anesthesia is preferred in cesarean section, and the influence on respiration and circulation in both maternal and infant should be reduced; while for severe or critically ill patients general anesthesia with endotracheal intubation should be adopted. The safety of medical environment should be ensured, and level-Ⅲ standard protection should be taken for anesthetists. Special attention and support should be given to maternal psychology. It is important to give full explanation before operation to reduce anxiety; to relieve the discomfort during operation to reduce tension; to avoid the bad mood of patients due to pain after operation.",,"anesthesia; Betacoronavirus; case report; cesarean section; complication; Coronavirus infection; female; human; infant; intraspinal drug administration; pregnancy; pregnancy complication; pregnancy outcome; preoperative care; virus pneumonia; Anesthesia; Betacoronavirus; Cesarean Section; Coronavirus Infections; Female; Humans; Infant; Injections, Spinal; Pneumonia, Viral; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Outcome; Preoperative Care",,,,NLM (Medline),10089292,,,32207592,Chinese,Zhejiang Da Xue Xue Bao Yi Xue Ban,Article,Final,,Scopus,2-s2.0-85082380010,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Chen Z., Fu J., Shu Q., Chen Y., Hua C., Li F., Lin R., Tang L., Wang T., Wang W., Wang Y., Xu W., Yang Z., Ye S., Yuan T., Zhang C., Zhang Y.",36631890700;8429908700;57210698907;57216112018;8286914700;57214912817;57214916948;35312719700;57215036731;57215073105;24588063700;57207174517;57215297783;57214933724;57214937478;23391480500;57214916717;,Diagnosis and treatment recommendation for pediatric coronavirus disease-19,2020,Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences,49,1,,1,8,,1,,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079535484&partnerID=40&md5=aeeaef350579d9f494f65d50c496f29b,"Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou, 310052, China","Chen, Z., Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou, 310052, China; Fu, J., Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou, 310052, China; Shu, Q., Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou, 310052, China; Chen, Y., Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou, 310052, China; Hua, C., Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou, 310052, China; Li, F., Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou, 310052, China; Lin, R., Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou, 310052, China; Tang, L., Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou, 310052, China; Wang, T., Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou, 310052, China; Wang, W., Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou, 310052, China; Wang, Y., Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou, 310052, China; Xu, W., Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou, 310052, China; Yang, Z., Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou, 310052, China; Ye, S., Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou, 310052, China; Yuan, T., Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou, 310052, China; Zhang, C., Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou, 310052, China; Zhang, Y., Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou, 310052, China",[No abstract available],,"COVID-19; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; child; Coronavirus infection; human; isolation and purification; virus pneumonia; Betacoronavirus; Child; Coronavirus Infections; Humans; Pneumonia, Viral",,,,NLM (Medline),10089292,,,32064795,Chinese,Zhejiang Da Xue Xue Bao Yi Xue Ban,Article,Final,,Scopus,2-s2.0-85079535484,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "El Zowalaty M.E., Järhult J.D.",36801657800;26664701000;,From SARS to COVID-19: A previously unknown SARS- related coronavirus (SARS-CoV-2) of pandemic potential infecting humans – Call for a One Health approach,2020,One Health,9,,100124,,,,,10.1016/j.onehlt.2020.100124,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081240462&doi=10.1016%2fj.onehlt.2020.100124&partnerID=40&md5=92f4f216c0d12917075b6d3b4ff557f8,"Zoonosis Science Center, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden; Infectious Diseases and Anti-Infective Therapy Research Group, College of Pharmacy and Sharjah Medical Research Institute, University of Sharjah, United Arab Emirates; Zoonosis Science Center, Department of Medical Sciences, Uppsala University, Uppsala, Sweden","El Zowalaty, M.E., Zoonosis Science Center, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden, Infectious Diseases and Anti-Infective Therapy Research Group, College of Pharmacy and Sharjah Medical Research Institute, University of Sharjah, United Arab Emirates; Järhult, J.D., Zoonosis Science Center, Department of Medical Sciences, Uppsala University, Uppsala, Sweden","Human coronaviruses continue to pose a threat to human health. The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in December 2019 which causes coronavirus disease-2019 (COVID-19), an acute respiratory disease marked the third introduction of a highly pathogenic coronavirus into the human population in the twenty-first century. This recent emergence of a previously unknown coronavirus in China leads to huge impacts on humans globally. Covid-19 is a challenge to global public health. Here, we discuss the COVID-19 outbreak in a one health context, highlighting the need for the implementation of one health measures and practices to improve human health and reduce the emergence of pandemic viruses. © 2020 The Authors",,influenza vaccine; 2019 novel coronavirus; adult respiratory distress syndrome; antibiotic resistance; Article; case fatality rate; cause of death; China; comorbidity; Coronavirinae; coronavirus disease 2019; Coronavirus infection; disease severity; disease transmission; hospitalization; human; infection control; influenza A; influenza vaccination; mortality; nonhuman; pneumonia; polymerase chain reaction; prevalence; public health; seroconversion; translational research; virus detection,"Monto, A.S., Epidemiology of viral respiratory infections (2002) Am. J. Med., 112 (6), pp. 4-12; Drosten, C., Identification of a novel coronavirus in patients with severe acute respiratory syndrome (2003) N. Engl. J. 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(2020) Nature; Roujian Lu*, X.Z., Li*, J., Niu*, P., Yang*, B., Wu*, H., Wang, W., Song, H., Bi, Y., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet, 395 (10224), pp. 565-574; Huang, C., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395 (10223), pp. 497-506; US CDC, Confirmed 2019-nCoV Cases Globally https://www.cdc.gov/coronavirus/2019-ncov/locations-confirmed-cases.html#map, Availabe at (Accessed 1 February 2020); (2020) Geographical Distribution of 2019-nCov Cases Globally, , https://www.ecdc.europa.eu/en/geographical-distribution-2019-ncov-cases, European Centre for Disease Prevention and Control Availabe at: (Accessed on 24 February 2020); WHO, Novel Coronavirus (2019-nCoV) Situation Reports (2020), https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200131-sitrep-11-ncov.pdf?sfvrsn=de7c0f7_2, Availabe at; Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with pneumonia in China, 2019 (2020) N. 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Dis., 66 (4), pp. 533-540; Weinstein, R.A., Planning for epidemics—the lessons of SARS (2004) N. Engl. J. Med., 350 (23), pp. 2332-2334; Menachery, V.D., Yount, B.L., Jr, Debbink, K., Agnihothram, S., Gralinski, L.E., Plante, J.A., Graham, R.L., Randell, S.H., A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence (2015) Nat Med., 12, pp. 1508-1513; Menachery, V.D., Yount, B.L., Sims, A.C., Debbink, K., Agnihothram, S.S., Gralinski, L.E., Graham, R.L., Swanstrom, J., SARS-like WIV1-CoV poised for human emergence (2016) Proceedings of the National Academy of Sciences, 113 (11), pp. 3048-3053; Fan, Y., Zhao, K., Shi, Z.L., Zhou, P., Bat Coronaviruses in China (2019) Viruses, 11 (3). , Mar, 2","El Zowalaty, M.E.; Zoonosis Science Center, Dep. of Medical Biochemistry and Microbiology, Uppsala UniversitySweden; email: elzow005@gmail.com",,Elsevier B.V.,23527714,,,,English,One Health,Article,Final,Open Access,Scopus,2-s2.0-85081240462,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Addie D.D., Curran S., Bellini F., Crowe B., Sheehan E., Ukrainchuk L., Decaro N.",7003910352;57215856263;57215855848;57215855262;57215857134;57215860916;6701636107;,Oral Mutian®X stopped faecal feline coronavirus shedding by naturally infected cats,2020,Research in Veterinary Science,130,,,222,229,,,10.1016/j.rvsc.2020.02.012,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082120660&doi=10.1016%2fj.rvsc.2020.02.012&partnerID=40&md5=98ccfd8a4337548d910bf7a85bd432c1,"Maison ZabalEtchebar 64470, France; Baker Street Ragdoll Cats, Liverpool, United Kingdom; Uxbridge, Middlesex, United Kingdom; Spinney Lodge Vets, Northampton, United Kingdom; Carbon Valley Animal Hospital, 101 W. Grant Ave, Firestone, CO 80520, United States; Department of Veterinary Medicine, University of Bari, Strada Provinciale per Casamassima, km 3, Bari, Valenzano (Bari) 70010, Italy","Addie, D.D., Maison ZabalEtchebar 64470, France; Curran, S., Baker Street Ragdoll Cats, Liverpool, United Kingdom; Bellini, F., Uxbridge, Middlesex, United Kingdom; Crowe, B., Uxbridge, Middlesex, United Kingdom; Sheehan, E., Spinney Lodge Vets, Northampton, United Kingdom; Ukrainchuk, L., Carbon Valley Animal Hospital, 101 W. Grant Ave, Firestone, CO 80520, United States; Decaro, N., Department of Veterinary Medicine, University of Bari, Strada Provinciale per Casamassima, km 3, Bari, Valenzano (Bari) 70010, Italy","Feline coronavirus (FCoV) is common among cats living indoors in groups. In about 10% of infected cats, a potentially lethal disease, feline infectious peritonitis (FIP) occurs. Virus transmission is faecal-oral. Mutian® Xraphconn (Mutian X) is a product marketed to treat cats with FIP but is also being used to stop virus shedding, although no clear guidelines exist for its use for this purpose. The aim of this study was to establish the minimum dose and treatment duration required to ensure viral clearance from the faeces of asymptomatic virus-shedding cats. In five multicat households, 29 cats naturally infected with FCoV and actively shedding virus in the faeces were given Mutian X pills. Virus shedding was monitored using reverse-transcription quantitative polymerase chain reaction (RT-qPCR) controlled for faecal inhibitors to ensure sensitivity. Mutian X given orally cleared the virus in 29 cats; although four cats required a repeated course to finally stop virus shedding. A dose of 4 mg/kg q24 h for four days was found to be the optimal treatment protocol: 2 mg/kg cleared only 80% of cats. Post-treatment using a sensitive RT-qPCR test was essential to ensure that virus clearance had been achieved, since failure to clear even one cat can result in re-infection of the others. Records of virus shedding by cats before treatment provided a retrospective control: significantly more cats stopped shedding virus after Mutian X than recovered from infection during the control period (p < .00001). This is the first report of the successful elimination of faecal FCoV shedding in chronically infected cats. © 2020 The Authors",Anti-virals; Faecal virus shedding; Feline coronavirus (FCoV); Feline infectious peritonitis (FIP); Itraconazole; Mutian X pills,,"Addie, D.D., Jarrett, O., A study of naturally occurring feline coronavirus infection in kittens (1992) Vet. Rec., 130, pp. 133-137; Addie, D.D., Jarrett, J.O., Use of a reverse-transcriptase polymerase chain reaction for monitoring feline coronavirus shedding by healthy cats (2001) Vet. 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Surg., 6 (2), pp. 53-58; Decaro, N., Buonavoglia, C., An update on canine coronaviruses: viral evolution and pathobiology (2008) Vet. 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Res., 42 (3), pp. 363-367; Pedersen, N.C., Kim, Y., Liu, H., Galasiti Kankanamalage, A.C., Eckstrand, C., Groutas, W.C., Bannasch, M., Chang, K.O., Efficacy of a 3C-like protease inhibitor in treating various forms of acquired feline infectious peritonitis (2018) J Feline Med Surg., 20 (4), pp. 378-392; Pedersen, N.C., Perron, M., Bannasch, M., Montgomery, E., Murakami, E., Liepnieks, M., Liu, H., Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis (2019) J Feline Med Surg., 21 (4), pp. 271-281; Scott, F.W., Update on FIP (1988) Proc. Kal. Kan. Symp., 12, pp. 43-47; Stoddart, M.E., Gaskell, R.M., Harbour, D.A., Gaskell, C.J., Virus shedding and immune responses in cats inoculated with cell culture-adapted feline infectious peritonitis virus. (1988) Veterinary Microbiology. 16 145-158, 16, pp. 145-158; Szajewska, H., Kołodziej, M., Gieruszczak-Białek, D., Skórka, A., Ruszczyński, M., Shamir, R., Systematic review with meta-analysis: lactobacillus rhamnosus GG for treating acute gastroenteritis in children - a 2019 update (2019) Aliment. Pharmacol. Ther., 49 (11), pp. 1376-1384; Takano, T., Akiyama, M., Doki, T., Hohdatsu, T., Antiviral activity of itraconazole against type I feline coronavirus infection (2019) Vet. Res., 50 (1), p. 5; Terada, Y., Matsui, N., Noguchi, K., Kuwata, R., Shimoda, H., Soma, T., Mochizuki, M., Maeda, K., Emergence of pathogenic coronaviruses in cats by homologous recombination between feline and canine coronaviruses (2014) PLoS One, 9 (9)","Addie, D.D.; Maison ZabalFrance; email: draddie@catvirus.com",,Elsevier B.V.,345288,,RVTSA,,English,Res. Vet. Sci.,Article,Final,Open Access,Scopus,2-s2.0-85082120660,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Liu H., Wang L.-L., Zhao S.-J., Kwak-Kim J., Mor G., Liao A.-H.",57205575422;57194448205;57215969210;6602324091;7006070920;7006509091;,Why are pregnant women susceptible to COVID-19? An immunological viewpoint,2020,Journal of Reproductive Immunology,139,,103122,,,,,10.1016/j.jri.2020.103122,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082454260&doi=10.1016%2fj.jri.2020.103122&partnerID=40&md5=aa35e7f0323eeb3de386a7368f0202ba,"Institute of Reproductive Health, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Reproductive Medicine and Immunology, Obstetrics and Gynecology, Department of Clinical Sciences, Chicago Medical School, Rosalind Franklin University of Medicine and Science, Vernon Hills, IL, United States; Microbiology and Immunology, Department of Foundational Science and Humanities, Chicago Medical School, Rosalind Franklin University of Medicine and Science, N. Chicago, IL, United States; C.S. Mott Center for Human Growth and Development, Department of Obstetrics and Gynecology, Wayne State University, Detroit, United States","Liu, H., Institute of Reproductive Health, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Wang, L.-L., Institute of Reproductive Health, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Zhao, S.-J., Institute of Reproductive Health, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Kwak-Kim, J., Reproductive Medicine and Immunology, Obstetrics and Gynecology, Department of Clinical Sciences, Chicago Medical School, Rosalind Franklin University of Medicine and Science, Vernon Hills, IL, United States, Microbiology and Immunology, Department of Foundational Science and Humanities, Chicago Medical School, Rosalind Franklin University of Medicine and Science, N. Chicago, IL, United States; Mor, G., C.S. Mott Center for Human Growth and Development, Department of Obstetrics and Gynecology, Wayne State University, Detroit, United States; Liao, A.-H., Institute of Reproductive Health, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China","The 2019 novel coronavirus disease (COVID-19) was first detected in December 2019 and became epidemic in Wuhan, Hubei Province, China. COVID-19 has been rapidly spreading out in China and all over the world. The virus causing COVID-19, SARS-CoV-2 has been known to be genetically similar to severe acute respiratory syndrome coronavirus (SARS-CoV) but distinct from it. Clinical manifestation of COVID-19 can be characterized by mild upper respiratory tract infection, lower respiratory tract infection involving non-life threatening pneumonia, and life-threatening pneumonia with acute respiratory distress syndrome. It affects all age groups, including newborns, to the elders. Particularly, pregnant women may be more susceptible to COVID-19 since pregnant women, in general, are vulnerable to respiratory infection. In pregnant women with COVID-19, there is no evidence for vertical transmission of the virus, but an increased prevalence of preterm deliveries has been noticed. The COVID-19 may alter immune responses at the maternal-fetal interface, and affect the well-being of mothers and infants. In this review, we focused on the reason why pregnant women are more susceptible to COVID-19 and the potential maternal and fetal complications from an immunological viewpoint. © 2020 Elsevier B.V.",COVID-19; Immunity; Maternal-fetal interface; Placenta; Pregnancy,,"Aghaeepour, N., An immune clock of human pregnancy (2017) Sci. Immunol., 2 (15); Boldogh, I., Medical Microbiology (1996), 4th edition University of Texas Medical Branch at Galveston Press Chapter 46; Chen, H., Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records (2020) Lancet, 395 (10226), pp. 809-815; Choi, G.B., The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring (2016) Science, 351, pp. 933-939; Favre, G., 2019-nCoV epidemic: what about pregnancies? (2020) Lancet, 395 (10224), p. e40. , Feb 6; Fried, M., Systemic inflammatory response to malaria during pregnancy is associated with pregnancy loss and preterm delivery (2017) Clin. Infect. Dis., 65, pp. 1729-1735; Gong, Y.X., The First Pregnant Woman With New Coronary Pneumonia Was Discharged From the People's Hospital of Wuhan University https://m.chinanews.com/wap/detail/zw/sh/2020/02-13/9089856.shtml; Guan, W.J., Clinical characteristics of 2019 novel coronavirus infection in China (2020) N Engl. J. Med.; Heymann, D.L., Shindo, N., COVID-19: what is next for public health? (2020) Lancet, 395 (10224), pp. 542-545; Huang, C., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395 (10223), pp. 497-506; Lu, R., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet, 395 (10224), pp. 565-574; Mor, G., The unique immunological and microbial aspects of pregnancy (2017) Nat. Rev. Immunol., 17, pp. 469-482; National Health Commission, WHO-China Joint Mission on Covid-19 Final Report (2020), http://www.nhc.gov.cn/jkj/s3578/202002/87fd92510d094e4b9bad597608f5cc2c.shtml, Feb 29; National Health Commission of the People's Republic of China, The Latest Situation of Novel Coronavirus Pneumonia As of 24:00 on 16 February (2020), http://www.nhc.gov.cn/xcs/yqfkdt/202002/18546da875d74445bb537ab014e7a1c6.shtml; National Health Commission of the People's Republic of China, The Notice of Launching Guideline on Diagnosis and Treatment of the 2019 Novel Coronavirus Disease (COVID-19) Infection (2020), http://www.nhc.gov.cn/yzygj/s7653p/202002/d4b895337e19445f8d728facf1e3e13a.shtml; Prompetchara, E., Immune responses in COVID-19 and potential vaccines: lessons learned from SARS and MERS epidemic (2020) Asian Pac. J. Allergy Immunol.; Qiao, J., What are the risks of COVID-19 infection in pregnant women? (2020) Lancet, 395 (10226), pp. 760-762; Racicot, K., Mor, G., Risks associated with viral infections during pregnancy (2017) J. Clin. Invest., 127, pp. 1591-1599; Tang, X.L., On the origin and continuing evolution of SARS-CoV-2 (2020) Nat. Sci. Rev.; Tetro, J.A., Is COVID-19 receiving ADE from other coronaviruses? (2020) Microbes. Infect., , Feb 22. pii: S1286-4579(20)30034-4; Werenberg Dreier, J., Fever and infections in pregnancy and risk of attention deficit/hyperactivity disorder in the offspring (2016) J. Child Psychol. Psychiatry, 57, pp. 540-548; Wong, S.F., Pregnancy and perinatal outcomes of women with severe acute respiratory syndrome (2004) Am. J. Obstet. Gynecol., 191, pp. 292-297; Yockey, L.J., Iwasaki, A., Interferons and proinflammatory cytokines in pregnancy and fetal development (2018) Immunity, 49, pp. 397-412; Zhu, H., Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia (2020) Transl. Pediatr., 9 (1), pp. 51-60","Liao, A.-H.; Institute of Reproductive Health, Center for Reproductive Medicine, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Rd, China; email: aihua_liao@sina.com",,Elsevier Ireland Ltd,1650378,,JRIMD,,English,J. Reprod. Immunol.,Review,Final,Open Access,Scopus,2-s2.0-85082454260,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Lippi G., Plebani M.",57205413642;57202559706;,Procalcitonin in patients with severe coronavirus disease 2019 (COVID-19): A meta-analysis,2020,Clinica Chimica Acta,505,,,190,191,,1,10.1016/j.cca.2020.03.004,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081226278&doi=10.1016%2fj.cca.2020.03.004&partnerID=40&md5=788889928c8bd2bfd092fedf826d30e1,"Section of Clinical Biochemistry, Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy; Department of Laboratory Medicine, University Hospital of Padova, Padova, Italy","Lippi, G., Section of Clinical Biochemistry, Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy; Plebani, M., Department of Laboratory Medicine, University Hospital of Padova, Padova, Italy",[No abstract available],Coronavirus; COVID-19; Procalcitonin; Prognosis,gamma interferon; interleukin 1beta; interleukin 6; procalcitonin; tumor necrosis factor; adult respiratory distress syndrome; artificial ventilation; clinical decision making; Coronavirinae; coronavirus disease 2019; Coronavirus infection; disease severity; high risk population; hospital admission; human; intensive care unit; Letter; nonhuman; pneumonia; priority journal; severe acute respiratory syndrome coronavirus 2,"World Health Organization, (2020), https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports/, Coronavirus disease 2019 (COVID-19) Situation Report – 49. Available at: Last accessed, March 9; Mattiuzzi, C., Lippi, G., Which lessons shall we learn from the 2019 novel coronavirus outbreak? (2020) Ann. Transl. Med., 8, p. 48; Cervellin, G., Schuetz, P., Lippi, G., Toward a holistic approach for diagnosing sepsis in the emergency department (2019) Adv. Clin. Chem., 92, pp. 201-216; Schuetz, P., Albrich, W., Mueller, B., Procalcitonin for diagnosis of infection and guide to antibiotic decisions: past, present and future (2011) BMC Med., 9, p. 107; Guan, W.-J., Ni, Z.-Y., Hu, Y., Liang, W.-H., Ou, C.-Q., He, J.-X., Liu, L., Zhong, N.-S., Clinical characteristics of coronavirus disease 2019 in China (2020) N. Engl. J. Med.; Zhang, J.J., Dong, X., Cao, Y.Y., Yuan, Y.D., Yang, Y.B., Yan, Y.Q., Clinical characteristics of 140 patients infected by SARS-CoV-2 in Wuhan, China (2020) Allergy, , (Epub ahead of print); Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506; Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Wang, B., Peng, Z., Clinical Characteristics of 138 hospitalized patients with 2019 novel coronavirus–infected pneumonia in Wuhan, China (2020) JAMA; Higgins, J.P., Thompson, S.G., Deeks, J.J., Altman, D.G., Measuring inconsistency in meta-analyses (2003) BMJ, 327, pp. 557-560; Lippi, G., Plebani, M., Laboratory abnormalities in patients with COVID-2019 infection (2020) Clin. Chem. Lab. Med.; Kotula, J.J., 3rd, Moore, W.S., 2nd, Chopra, A., Cies, J.J., Association of procalcitonin value and bacterial coinfections in pediatric patients with viral lower respiratory tract infections admitted to the pediatric intensive care unit (2018) J. Pediatr. Pharmacol. Ther., 23, pp. 466-472","Plebani, M.; Department of Laboratory Medicine, University-Hospital of Padova, Via Giustiniani 2, Italy; email: mario.plebani@unipd.it",,Elsevier B.V.,98981,,CCATA,32145275,English,Clin. Chim. Acta,Letter,Final,Open Access,Scopus,2-s2.0-85081226278,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Marty A.M., Jones M.K.",57195352172;57215208701;,The novel Coronavirus (SARS-CoV-2) is a one health issue,2020,One Health,9,,100123,,,,,10.1016/j.onehlt.2020.100123,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080054477&doi=10.1016%2fj.onehlt.2020.100123&partnerID=40&md5=ee7b24a40e5a60b50cae7e9e6580d24e,"Infectious Diseases, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, United States; School of Veterinary Science, The University of Queensland, Brisbane, Qld 4072, Australia","Marty, A.M., Infectious Diseases, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, United States; Jones, M.K., School of Veterinary Science, The University of Queensland, Brisbane, Qld 4072, Australia",[No abstract available],,2019 novel coronavirus; China; Coronavirus infection; Editorial; epidemic; genetic analysis; human; nonhuman; One Health; patient isolation; public health; viral genetics; virus transmission,"Ellis, A., FIU experts assess global impacts of China's coronavirus outbreak (2020) Fiu News, , https://news.fiu.edu/2020/fiu-experts-assess-global-impacts-of-chinas-coronavirus-outbreak; Urcosta, R.B., The geopolitical consequences of the coronavirus outbreak 2020 Jan 31 (2020) The Diplomat, , https://thediplomat.com/2020/01/the-geopolitical-consequences-of-the-coronavirus-outbreak/; Seifried, O., Histopathology of infectious Laryngotracheitis in chickens (1931) J. 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Vet. Med., 137, pp. 112-118; Lu, R., Zhao, X., Li, J., Niu, P., Yang, B., Wu, H., Wang, W., Tan, W., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor bindin (2020) Lanset, 20, pp. 30251-30258. , In press","Marty, A.M.; Infectious Diseases, Herbert Wertheim College of Medicine, Florida International UniversityUnited States; email: amarty@fiu.edu",,Elsevier B.V.,23527714,,,,English,One Health,Editorial,Final,Open Access,Scopus,2-s2.0-85080054477,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Guo R., Fan B., Chang X., Zhou J., Zhao Y., Shi D., Yu Z., He K., Li B.",24173114900;56067970100;57210986664;57216100434;57211496827;57211283236;50761549900;23970760800;57100361000;,Characterization and evaluation of the pathogenicity of a natural recombinant transmissible gastroenteritis virus in China,2020,Virology,545,,,24,32,,,10.1016/j.virol.2020.03.001,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081031377&doi=10.1016%2fj.virol.2020.03.001&partnerID=40&md5=f389825e92844afdba1e1d55ba12ec09,"Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Nanjing, Jiangsu 210014, China; Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, Jiangsu 225000, China; Jiangsu Key Laboratory of Zoonoses, Yangzhou University, Yangzhou, Jiangsu 225000, China; Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base of Ministry of Science and Technology, Nanjing, 210014, China; College of Animal Science and Technology, Hebei Normal University of Science and Technology, Qinhuangdao, 066004, China; School of Food and Biological Engineering, Jiangsu University, Zhenjiang, 212013, China","Guo, R., Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Nanjing, Jiangsu 210014, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, Jiangsu 225000, China, Jiangsu Key Laboratory of Zoonoses, Yangzhou University, Yangzhou, Jiangsu 225000, China; Fan, B., Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Nanjing, Jiangsu 210014, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, Jiangsu 225000, China, Jiangsu Key Laboratory of Zoonoses, Yangzhou University, Yangzhou, Jiangsu 225000, China, Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base of Ministry of Science and Technology, Nanjing, 210014, China; Chang, X., Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Nanjing, Jiangsu 210014, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, Jiangsu 225000, China, Jiangsu Key Laboratory of Zoonoses, Yangzhou University, Yangzhou, Jiangsu 225000, China; Zhou, J., Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Nanjing, Jiangsu 210014, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, Jiangsu 225000, China, Jiangsu Key Laboratory of Zoonoses, Yangzhou University, Yangzhou, Jiangsu 225000, China; Zhao, Y., Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Nanjing, Jiangsu 210014, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, Jiangsu 225000, China, Jiangsu Key Laboratory of Zoonoses, Yangzhou University, Yangzhou, Jiangsu 225000, China; Shi, D., Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Nanjing, Jiangsu 210014, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, Jiangsu 225000, China, Jiangsu Key Laboratory of Zoonoses, Yangzhou University, Yangzhou, Jiangsu 225000, China, College of Animal Science and Technology, Hebei Normal University of Science and Technology, Qinhuangdao, 066004, China; Yu, Z., Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Nanjing, Jiangsu 210014, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, Jiangsu 225000, China, Jiangsu Key Laboratory of Zoonoses, Yangzhou University, Yangzhou, Jiangsu 225000, China; He, K., Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Nanjing, Jiangsu 210014, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, Jiangsu 225000, China, Jiangsu Key Laboratory of Zoonoses, Yangzhou University, Yangzhou, Jiangsu 225000, China; Li, B., Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Key Laboratory of Veterinary Biological Engineering and Technology, Ministry of Agriculture, Nanjing, Jiangsu 210014, China, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, Jiangsu 225000, China, Jiangsu Key Laboratory of Zoonoses, Yangzhou University, Yangzhou, Jiangsu 225000, China, School of Food and Biological Engineering, Jiangsu University, Zhenjiang, 212013, China","Porcine transmissible gastroenteritis virus (TGEV) is one of the major etiological agents of viral enteritis and fetal diarrhea in suckling piglets. In this study, a TGEV JS2012 strain was isolated from the feces of piglets in Jiangsu Province, China. The phylogenetic analysis showed that TGEV JS2012 was placed between the Purdue and the Miller clusters. Analysis of recombination confirmed that TGEV JS2012 is a natural recombinant strain between Miller M6 and Purdue 115. Similar to Miller M6, virulent Purdue and China strain TS, in S gene the JS2012 maintained genetic integrity and the characteristics of the TGEV virulent strains. In vivo, TGEV JS2012 caused 100% mortality in newborn piglets, indicating the strong pathogenicity of this isolate. These results reveal that the JS2012 is a novel natural recombinant TGEV with high virulence. Our findings provide valuable information about genetic diversity and infection mechanism of the coronavirus family. © 2020 Elsevier Inc.",Pathogenicity; Phylogenetic; Recombination; TGEV,animal experiment; article; China; controlled study; feces; female; genetic variability; human; in vivo study; male; mortality; newborn; nonhuman; phylogeny; piglet; Transmissible gastroenteritis virus; virus virulence,"Ballesteros, M.L., Sanchez, C.M., Enjuanes, L., Two amino acid changes at the N-terminus of transmissible gastroenteritis coronavirus spike protein result in the loss of enteric tropism (1997) Virology, 227, pp. 378-388; Collins, A.R., Knobler, R.L., Powell, H., Buchmeier, M.J., Monoclonal antibodies to murine hepatitis virus-4 (strain JHM) define the viral glycoprotein responsible for attachment and cell--cell fusion (1982) Virology, 119, pp. 358-371; Delmas, B., Rasschaert, D., Godet, M., Gelfi, J., Laude, H., Four major antigenic sites of the coronavirus transmissible gastroenteritis virus are located on the amino-terminal half of spike glycoprotein S (1990) J. Gen. Virol., 71 (6), pp. 1313-1323; Doyle, L.P., Hutchings, L.M., A transmissible gastroenteritis in pigs (1946) J. Am. Vet. Med. Assoc., 108, pp. 257-259; Enjuanes, L., Dediego, M.L., Alvarez, E., Deming, D., Sheahan, T., Baric, R., Vaccines to prevent severe acute respiratory syndrome coronavirus-induced disease (2008) Virus Res., 133, pp. 45-62; Enjuanes, L., Smerdou, C., Castilla, J., Anton, I.M., Torres, J.M., Sola, I., Golvano, J., Pintado, B., Development of protection against coronavirus induced diseases. A review (1995) Adv. Exp. Med. Biol., 380, pp. 197-211; Fan, B., Jiao, D., Zhao, X., Pang, F., Xiao, Q., Yu, Z., Mao, A., Li, B., Characterization of Chinese porcine epidemic diarrhea virus with novel insertions and deletions in genome (2017) Sci. Rep., 7, p. 44209; Fan, B., Yu, Z., Pang, F., Xu, X., Zhang, B., Guo, R., He, K., Li, B., Characterization of a pathogenic full-length cDNA clone of a virulent porcine epidemic diarrhea virus strain AH2012/12 in China (2017) Virology, 500, pp. 50-61; Hou, Y., Yue, X., Cai, X., Wang, S., Liu, Y., Yuan, C., Cui, L., Yang, Z., Complete genome of transmissible gastroenteritis virus AYU strain isolated in Shanghai, China (2012) J. Virol., 86, p. 11935; Jimenez, G., Correa, I., Melgosa, M.P., Bullido, M.J., Enjuanes, L., Critical epitopes in transmissible gastroenteritis virus neutralization (1986) J. Virol., 60, pp. 131-139; Jung, K., Wang, Q., Scheuer, K.A., Lu, Z., Zhang, Y., Saif, L.J., Pathology of US porcine epidemic diarrhea virus strain PC21A in gnotobiotic pigs (2014) Emerg. Infect. Dis., 20, pp. 662-665; Kemeny, L.J., Woods, R.D., Quantitative transmissible gastroenteritis virus shedding patterns in lactating sows (1977) Am. J. Vet. Res., 38, pp. 307-310; Kim, B., Chae, C., In situ hybridization for the detection of transmissible gastroenteritis virus in pigs and comparison with other methods (2001) Can. J. Vet. Res., 65, pp. 33-37; Kim, B., Chae, C., Experimental infection of piglets with transmissible gastroenteritis virus: a comparison of three strains (Korean, Purdue and Miller) (2002) J. Comp. Pathol., 126, pp. 30-37; Kim, L., Hayes, J., Lewis, P., Parwani, A.V., Chang, K.O., Saif, L.J., Molecular characterization and pathogenesis of transmissible gastroenteritis coronavirus (TGEV) and porcine respiratory coronavirus (PRCV) field isolates co-circulating in a swine herd (2000) Arch. Virol., 145, pp. 1133-1147; Krempl, C., Schultze, B., Laude, H., Herrler, G., Point mutations in the S protein connect the sialic acid binding activity with the enteropathogenicity of transmissible gastroenteritis coronavirus (1997) J. Virol., 71, pp. 3285-3287; Li, J.Q., Cheng, J., Lan, X., Li, X.R., Li, W., Yin, X.P., Li, B.Y., Liu, J.X., Complete genomic sequence of transmissible gastroenteritis virus TS and 3' end sequence characterization following cell culture (2010) Virol. Sin., 25, pp. 213-224; Lin, C.M., Annamalai, T., Liu, X., Gao, X., Lu, Z., El-Tholoth, M., Hu, H., Wang, Q., Experimental infection of a US spike-insertion deletion porcine epidemic diarrhea virus in conventional nursing piglets and cross-protection to the original US PEDV infection (2015) Vet. Res., 46, p. 134; Lu, C.Z., Wang, L., Yang, C., Han, W., Establishment of double PCR detection method of transmissible gastroenteritis virus(TGEV)and porcine epidemic diarrhea virus(PEDV). 42 (2015) China Anim. Husb. Vet. Med., 42, pp. 1377-1382; Madson, D.M., Arruda, P.H., Magstadt, D.R., Burrough, E.R., Hoang, H., Sun, D., Bower, L.P., Yoon, K.J., Characterization of porcine epidemic diarrhea virus isolate US/Iowa/18984/2013 infection in 1-day-old cesarean-derived colostrum-deprived piglets (2016) Vet. Pathol., 53, pp. 44-52; McGoldrick, A., Lowings, J.P., Paton, D.J., Characterisation of a recent virulent transmissible gastroenteritis virus from Britain with a deleted ORF 3a (1999) Arch. Virol., 144, pp. 763-770; Paul, P.S., Vaughn, E.M., Halbur, P.G., Pathogenicity and sequence analysis studies suggest potential role of gene 3 in virulence of swine enteric and respiratory coronaviruses (1997) Adv. Exp. Med. Biol., 412, pp. 317-321; Pensaert, M.B., Debouck, P., Reynolds, D.J., An immunoelectron microscopic and immunofluorescent study on the antigenic relationship between the coronavirus-like agent, CV 777, and several coronaviruses (1981) Arch. Virol., 68, pp. 45-52; Penzes, Z., Gonzalez, J.M., Calvo, E., Izeta, A., Smerdou, C., Mendez, A., Sanchez, C.M., Enjuanes, L., Complete genome sequence of transmissible gastroenteritis coronavirus PUR46-MAD clone and evolution of the purdue virus cluster (2001) Virus Gene., 23, pp. 105-118; Pritchard, G.C., Transmissible gastroenteritis in endemically infected breeding herds of pigs in East Anglia, 1981-85 (1987) Vet. Rec., 120, pp. 226-230; Reguera, J., Santiago, C., Mudgal, G., Ordono, D., Enjuanes, L., Casasnovas, J.M., Structural bases of coronavirus attachment to host aminopeptidase N and its inhibition by neutralizing antibodies (2012) PLoS Pathog., 8; Sanchez, C.M., Izeta, A., Sanchez-Morgado, J.M., Alonso, S., Sola, I., Balasch, M., Plana-Duran, J., Enjuanes, L., Targeted recombination demonstrates that the spike gene of transmissible gastroenteritis coronavirus is a determinant of its enteric tropism and virulence (1999) J. Virol., 73, pp. 7607-7618; Siddell, S., Wege, H., Ter Meulen, V., The biology of coronaviruses (1983) J. Gen. Virol., 64 (4), pp. 761-776; Sola, I., Alonso, S., Zuniga, S., Balasch, M., Plana-Duran, J., Enjuanes, L., Engineering the transmissible gastroenteritis virus genome as an expression vector inducing lactogenic immunity (2003) J. Virol., 77, pp. 4357-4369; Vaughn, E.M., Halbur, P.G., Paul, P.S., Sequence comparison of porcine respiratory coronavirus isolates reveals heterogeneity in the S, 3, and 3-1 genes (1995) J. Virol., 69, pp. 3176-3184; Wesley, R.D., Woods, R.D., Cheung, A.K., Genetic analysis of porcine respiratory coronavirus, an attenuated variant of transmissible gastroenteritis virus (1991) J. Virol., 65, pp. 3369-3373; Wood, E.N., Pritchard, G.C., Gibson, E.A., Transmissible gastroenteritis of pigs (1981) Vet. Rec., 108, p. 41; Woods, R.D., Wesley, R.D., Immune response in sows given transmissible gastroenteritis virus or canine coronavirus (1986) Am. J. Vet. Res., 47, pp. 1239-1242; Xiao, H., Xu, L.H., Yamada, Y., Liu, D.X., Coronavirus spike protein inhibits host cell translation by interaction with eIF3f (2008) PloS One, 3; Zhang, Q., Hu, R., Tang, X., Wu, C., He, Q., Zhao, Z., Chen, H., Wu, B., Occurrence and investigation of enteric viral infections in pigs with diarrhea in China (2013) Arch. Virol., 158, pp. 1631-1636; Zhang, X., Hasoksuz, M., Spiro, D., Halpin, R., Wang, S., Stollar, S., Janies, D., Saif, L., Complete genomic sequences, a key residue in the spike protein and deletions in nonstructural protein 3b of US strains of the virulent and attenuated coronaviruses, transmissible gastroenteritis virus and porcine respiratory coronavirus (2007) Virology, 358, pp. 424-435; Zhang, X., Zhu, Y., Zhu, X., Shi, H., Chen, J., Shi, D., Yuan, J., Feng, L., Identification of a natural recombinant transmissible gastroenteritis virus between Purdue and Miller clusters in China (2017) Emerg. Microb. Infect., 6, p. e74; Zhu, Y., Liang, L., Luo, Y., Wang, G., Wang, C., Cui, Y., Ai, X., Cui, S., A sensitive duplex nanoparticle-assisted PCR assay for identifying porcine epidemic diarrhea virus and porcine transmissible gastroenteritis virus from clinical specimens (2017) Virus Gene., 53, pp. 71-76; Zuniga, S., Pascual-Iglesias, A., Sanchez, C.M., Sola, I., Enjuanes, L., Virulence factors in porcine coronaviruses and vaccine design (2016) Virus Res., 226, pp. 142-151","Li, B.; Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, 50 Zhong-ling Street, China; email: libinana@126.com",,Academic Press Inc.,426822,,VIRLA,,English,Virology,Article,Final,,Scopus,2-s2.0-85081031377,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zaher N.H., Mostafa M.I., Altaher A.Y.",14017054100;57213820459;57213434131;,"Design, synthesis and molecular docking of novel triazole derivatives as potential CoV helicase inhibitors",2020,Acta Pharmaceutica,70,2,,145,159,,2,10.2478/acph-2020-0024,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85078070906&doi=10.2478%2facph-2020-0024&partnerID=40&md5=5921e57a2ac98965148a74f7cdb8e93f,"Radiation Drug Research Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt; Department of Pharmacology, College of Veterinary Medicine, Cairo University, Gizah, Egypt; Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, King Faisal University, Alhasa, Saudi Arabia","Zaher, N.H., Radiation Drug Research Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt; Mostafa, M.I., Department of Pharmacology, College of Veterinary Medicine, Cairo University, Gizah, Egypt; Altaher, A.Y., Department of Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, King Faisal University, Alhasa, Saudi Arabia","Middle East respiratory syndrome coronavirus (MERS-CoV) had emerged and spread because of the worldwide travel and inefficient healthcare provided for the infected patients in several countries. Herein we investigated the anti-MERS-CoV activity of newly synthesized sixteen halogenated triazole compounds through the inhibition of helicase activity using the FRET assay. All new compounds underwent justification for their target structures via microanalytical and spectral data. SAR studies were performed. Biological results revealed that the most potent compounds were 4-(cyclopent-1-en-3-ylamino)-5-(2-(4-iodophenyl)hydrazinyl)-4H-1,2,4-triazole-3-thiol (16) and 4-(cyclopent-1-en-3-ylamino)-5-[2-(4-chlorophenyl)hydrazinyl]-4H-1,2,4-triazole-3-thiol (12). In silico molecular docking of the most potent compounds was performed to the active binding site of MERS-CoV helicase nsp13. Molecular docking results are in agreement with experimental findings. © 2020 Nashwa Hafez Zaher et al., published by Sciendo 2020.",anti-MERS-CoV activity; docking; MERS-CoV helicase; triazole derivatives,"4 (cyclopent 1 en 3 ylamino) 5 [2 (2 bromophenyl)hydrazinyl] 4h 1,2,4 triazole 3 thiol; 4 (cyclopent 1 en 3 ylamino) 5 [2 (2 chlorophenyl) hydrazinyl] 4h 1,2,4 triazole 3 thiol; 4 (cyclopent 1 en 3 ylamino) 5 [2 (2 fluorophenyl) hydrazinyl] 4h 1,2,4 triazole 3 thiol; 4 (cyclopent 1 en 3 ylamino) 5 [2 (2 iodophenyl)hydrazinyl] 4h 1,2,4 triazole 3 thiol; 4 (cyclopent 1 en 3 ylamino) 5 [2 (4 bromophenyl)hydrazinyl] 4h 1,2,4 triazole 3 thiol; 4 (cyclopent 1 en 3 ylamino) 5 [2 (4 chlorophenyl hydrazinyl] 4h 1,2,4 triazole 3 thiol; 4 (cyclopent 1 en 3 ylamino) 5 [2 (4 fluorophenyl) hydrazinyl] 4h 1,2,4 triazole 3 thiol; 4 (cyclopent 1 en 3 ylamino) 5 [2 (4 iodophenyl)hydrazinyl] 4h 1,2,4 triazole 3 thiol; 4 amino 5 (2 chlorophenyl hydrazine) 4h 1,2,4 triazole 3 thiol; 4 amino 5 (2 bromophenyl hydrazine) 4h 1,2,4 triazole 3 thiol; 4 amino 5 (2 fluorophenyl hydrazine) 4h 1,2,4 triazole 3 thiol; 4 amino 5 (2 iodophenyl hydrazine) 4h 1,2,4 triazole 3 thiol; 4 amino 5 (4 bromophenyl hydrazine) 4h 1,2,4 triazole 3 thiol; 4 amino 5 (4 chlorophenyl hydrazine) 4h 1,2,4 triazole 3 thiol; 4 amino 5 (4 fluorophenyl hydrazine) 4h 1,2,4 triazole 3 thiol; 4 amino 5 (4 iodophenyl hydrazine) 4h 1,2,4 triazole 3 thiol; antivirus agent; helicase; triazole derivative; unclassified drug; antiviral activity; Article; ATPase activity assay; binding affinity; binding site; carbon nuclear magnetic resonance; chemical structure; computer model; controlled study; crystal structure; drug design; drug synthesis; enzyme activity; fluorescence resonance energy transfer; Fourier transform infrared spectroscopy; IC50; melting point; Middle East respiratory syndrome; Middle East respiratory syndrome coronavirus; molecular docking; nonhuman; polyacrylamide gel electrophoresis; polymerase chain reaction; proton nuclear magnetic resonance; structure activity relation","Graham, R.L., Donaldson, E.F., Baric, R.S., A decade after SARS: Strategies for controlling emerging coronaviruses (2013) Nat. 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Med., 349, pp. 2431-2441. , https://doi.org/10.1056/NEJMra032498; Penttinen, P.M., Kaasik-Aaslav, K., Friaux, A., Donachie, A., Sudre, B., Amato-Gauci, A.J., Memish, Z.A., Coulombier, D., Taking stock of the first 133 MER S coronavirus cases globally-Is the epidemic changing? (2013) Euro Surveill, 18, pp. 1-5. , https://doi.org/10.2807/1560-7917.ES2013.18.39.20596; World Health Organization, MERS-CoV Global Summary and Assessment of Risk, (WHO/MERS/RA/ August18), WHO, Geneva 2018; Adedeji, A.O., Sarafianos, S.G., Antiviral drugs specific for coronaviruses in preclinical development (2014) Curr. Opin. 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Des., 12, pp. 1315-1338. , https://doi.org/10.2174/138161206776361147; Hao, W., Wojdyla, J.A., Zhao, R., Han, R., Das, R., Zlatev, I., Manoharan, M., Cui, S., Crystal structure of Middle East respiratory syndrome coronavirus helicase (2017) PLoS Pathog., 13, p. e1006474. , https://doi.org/10.1371/j.ppat.1006474; Adedeji, A.O., Lazarus, H., Biochemical characterization of Middle East respiratory syndrome coronavirus helicase (2016) MSphere, 1, pp. e00235-e00316. , https://doi.org/org/10.1128/mSphere.00235-16; Dheer, D., Singh, V., Shankar, R., Medicinal attributes of 1,2,3-triazoles: Current developments (2017) Bioorg. Chem., 71, pp. 30-54. , https://doi.org/10.1016/j.bioorg.2017.01.010; He, Y.W., Dong, C.Z., Zhao, J.Y., Ma, L., Li, Y.H., Aisa, H.A., 1,2,3-Triazole-containing derivatives of rupestonic acid: Click-chemical synthesis and antiviral activities against influenza viruses (2014) Eur. J. Med. 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Chem., 32, pp. 259-286. , https://doi.org/10.1.1.574.4827; Tanner, J.A., Watt, R.M., Chai, Y.B., Lu, L.Y., Lin, M.C., Peiris, J.S., Poon, L.L., Huang, J.D., The severe acute respiratory syndrome (SARS) coronavirus NTPase/helicase belongs to a distinct class of 5' to 3' viral helicases (2003) J. Biol. Chem., 278, pp. 39578-39582. , https://doi.org/10.1074/jbc.C300328200; Porter, D.J.T., Inhibition of the hepatitis C virus helicase-associated ATPase activity by the combination of ADP NaF, MgCl2, and poly(rU)-Two ADP binding sites on the enzyme-nucleic acid complex (1998) J. Biol. Chem., 273, pp. 7390-7396. , https://doi.org/10.1074/jbc.273.13.7390; Boguszewska-Chachulska, A.M., Krawczyk, M., Stankiewicz, A., Gozdek, A., Haenni, A.-L., Strokovskaya, L., Direct fluorometric measurement of hepatitis C virus helicase activity (2004) FEBS Lett., 567, pp. 253-258. , https://doi.org/10.1016/j.febslet.2004.04.072; Abdel-Hamid, M.K., Abdel-Hafez, A.A., El-Koussi, N.A., Mahfouz, N.M., Innocenti, A., Supuran, C.T., Design synthesis, and docking studies of new 1,3,4-thiadiazole-2-thione derivatives with carbonic anhydrase inhibitory activity (2007) Bioorg. Med. Chem. 15, pp. 6975-6984. , https://doi.org/10.1016/j.bmc.2007.07.044; Tanner, J.A., Zheng, B.J., Zhou, J., Watt, R.M., Jiang, J.Q., Wong, K.L., Lin, Y.P., Huang, J.D., The adamantane-derived bananins are potent inhibitors of the helicase activities and replication of SARS coronavirus (2005) Chem. Biol., 12, pp. 303-311. , https://doi.org/10.1016/j.chembiol.2005.01.006; Wu, Z.-Y., Liu, N., Qin, B., Huang, L., Yu, F., Qian, K., Morris-Natschke, S.L., Xie, L., Optimization of the antiviral potency and lipophilicity of halogenated 2,6-diarylpyridinamines as a novel class of HIV-1 NNRTIS (2014) ChemMedChem, 9, pp. 1546-1555. , https://doi.org/10.1002/cmdc.201400075","Zaher, N.H.; Radiation Drug Research Department, National Center for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA)Egypt; email: nashwazah@hotmail.com",,Sciendo,13300075,,ACPHE,31955138,English,Acta Pharm.,Article,Final,Open Access,Scopus,2-s2.0-85078070906,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Liu R., Han H., Liu F., Lv Z., Wu K., Liu Y., Feng Y., Zhu C.",57215591014;57209229200;57215557062;57215585009;8237740000;7410231924;55547104954;23007074300;,"Positive rate of RT-PCR detection of SARS-CoV-2 infection in 4880 cases from one hospital in Wuhan, China, from Jan to Feb 2020",2020,Clinica Chimica Acta,505,,,172,175,,,10.1016/j.cca.2020.03.009,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081208379&doi=10.1016%2fj.cca.2020.03.009&partnerID=40&md5=12902133c2d0291d9f4e66fd7fa9e5f1,"Dept. of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, China; Dept. State Key Laboratory of Virology (Wuhan University), College of Life Sciences of Wuhan University, Wuhan 430072, Hubei, China; Dept. Wuhan Institute of Biotechnology, Wuhan 430075, Hubei, China; School of Basic Medical Sciences, Wuhan University, Wuhan 430071, Hubei, China","Liu, R., Dept. of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, China; Han, H., Dept. of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, China; Liu, F., Dept. State Key Laboratory of Virology (Wuhan University), College of Life Sciences of Wuhan University, Wuhan 430072, Hubei, China, Dept. Wuhan Institute of Biotechnology, Wuhan 430075, Hubei, China; Lv, Z., Dept. of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, China; Wu, K., Dept. State Key Laboratory of Virology (Wuhan University), College of Life Sciences of Wuhan University, Wuhan 430072, Hubei, China; Liu, Y., Dept. State Key Laboratory of Virology (Wuhan University), College of Life Sciences of Wuhan University, Wuhan 430072, Hubei, China; Feng, Y., School of Basic Medical Sciences, Wuhan University, Wuhan 430071, Hubei, China; Zhu, C., Dept. of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, China","Background: There's an outbreak of a novel coronavirus (SARS-CoV-2) infection since December 2019, first in China, and currently with more than 80 thousand confirmed infection globally in 29 countries till March 2, 2020. Identification, isolation and caring for patients early are essential to limit human-to-human transmission including reducing secondary infections among close contacts and health care workers, preventing transmission amplification events. The RT-PCR detection of viral nucleic acid test (NAT) was one of the most quickly established laboratory diagnosis method in a novel viral pandemic, just as in this COVID-19 outbreak. Methods: 4880 cases that had respiratory infection symptoms or close contact with COVID-19 patients in hospital in Wuhan, China, were tested for SARS-CoV-2 infection by use of quantitative RT-PCR (qRT-PCR) on samples from the respiratory tract. Positive rates were calculated in groups divided by genders or ages. Results: The positive rate was about 38% for the total 4880 specimens. Male and older population had a significant higher positive rates. However, 57% was positive among the specimens from the Fever Clinics. Binary logistic regression analysis showed that age, not gender, was the risk factor for SARS-CoV-2 infection in fever clinics. Conclusions: Therefore, we concluded that viral NAT played an important role in identifying SARS-CoV-2 infection. © 2020 Elsevier B.V.",COVID-19; Nucleic acid test; Positive rate; SARS-CoV-2,adult; age; aged; Article; China; coronavirus disease 2019; female; hospital; human; infection risk; major clinical study; male; nose smear; nucleic acid analysis; priority journal; real time polymerase chain reaction; SARS coronavirus; severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; sex difference; throat culture; viral nucleic acid test; virus detection,"Fang, Y., Zhang, H., Xie, J., Sensitivity of chest CT for COVID-19: comparison to RT-PCR (2020) Radiology, p. 200432; Xie, X., Zhong, Z., Zhao, W., Zheng, C., Wang, F., Liu, J., Chest CT for typical 2019-nCoV pneumonia: relationship to negative RT-PCR testing (2020) Radiology, p. 200343; Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) New Engl. J. Med.; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506; Zhu, N., Zhang, D., Wang, W., A novel coronavirus from patients with Pneumonia in China, 2019 (2020) New Engl. J. Med., 382, pp. 727-733; Wang, D., Hu, B., Hu, C., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected Pneumonia in Wuhan, China (2020) Jama; Pan, F., Ye, T., Sun, P., Time course of lung changes on chest CT during recovery from 2019 novel coronavirus (COVID-19) Pneumonia (2020) Radiology, p. 200370; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395, pp. 507-513","Feng, Y.; School of Basic Medical Sciences, Wuhan UniversityChina; email: yongfeng@whu.edu.cn",,Elsevier B.V.,98981,,CCATA,32156607,English,Clin. Chim. Acta,Article,Final,Open Access,Scopus,2-s2.0-85081208379,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Shereen M.A., Khan S., Kazmi A., Bashir N., Siddique R.",57212456485;57192387486;57215934980;57212668641;57192396029;,"COVID-19 infection: Origin, transmission, and characteristics of human coronaviruses",2020,Journal of Advanced Research,24,,,91,98,,,10.1016/j.jare.2020.03.005,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082414378&doi=10.1016%2fj.jare.2020.03.005&partnerID=40&md5=c22e0ab798b1bafd50a4d77d1ff7f12c,"The Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China; State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China; College of Life Sciences, Wuhan University, Wuhan, China","Shereen, M.A., The Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China, State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China; Khan, S., The Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Kazmi, A., College of Life Sciences, Wuhan University, Wuhan, China; Bashir, N., The Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Siddique, R., The Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China","The coronavirus disease 19 (COVID-19) is a highly transmittable and pathogenic viral infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged in Wuhan, China and spread around the world. Genomic analysis revealed that SARS-CoV-2 is phylogenetically related to severe acute respiratory syndrome-like (SARS-like) bat viruses, therefore bats could be the possible primary reservoir. The intermediate source of origin and transfer to humans is not known, however, the rapid human to human transfer has been confirmed widely. There is no clinically approved antiviral drug or vaccine available to be used against COVID-19. However, few broad-spectrum antiviral drugs have been evaluated against COVID-19 in clinical trials, resulted in clinical recovery. In the current review, we summarize and comparatively analyze the emergence and pathogenicity of COVID-19 infection and previous human coronaviruses severe acute respiratory syndrome coronavirus (SARS-CoV) and middle east respiratory syndrome coronavirus (MERS-CoV). We also discuss the approaches for developing effective vaccines and therapeutic combinations to cope with this viral outbreak. © 2020",Coronaviruses; COVID-19; Origin; Outbreak; Spread,,"Zhong, N., Zheng, B., Li, Y., Poon, L., Xie, Z., Chan, K., Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China, in February, 2003 (2003) The Lancet, 362 (9393), pp. 1353-1358; Wang, N., Shi, X., Jiang, L., Zhang, S., Wang, D., Tong, P., Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4 (2013) Cell Res, 23 (8), p. 986; Cui, J., Li, F., Shi, Z.-L., Origin and evolution of pathogenic coronaviruses (2019) Nat Rev Microbiol, 17 (3), pp. 181-192; Lai, C.-C., Shih, T.-P., Ko, W.-C., Tang, H.-J., Hsueh, P.-R., Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and corona virus disease-2019 (COVID-19): the epidemic and the challenges (2020) Int J Antimicrob Agents, 105924; Organization, W.H., (2020), Laboratory testing for coronavirus disease 2019 (COVID-19) in suspected human cases: interim guidance, 2 March 2020. 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Adv. Res.,Review,Final,Open Access,Scopus,2-s2.0-85082414378,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Lin C., Ding Y., Xie B., Sun Z., Li X., Chen Z., Niu M.",57211792429;57215196345;57215188785;57215191958;57215194337;56099405700;57215205444;,Asymptomatic novel coronavirus pneumonia patient outside Wuhan: The value of CT images in the course of the disease,2020,Clinical Imaging,63,,,7,9,,1,10.1016/j.clinimag.2020.02.008,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85080037652&doi=10.1016%2fj.clinimag.2020.02.008&partnerID=40&md5=c28a769dfe3f483102674be10a0937f3,"Department of Radiology, Lanzhou Lung Hospital, Lanzhou, 730000, China; Gansu Provincial Infectious Disease Hospital, Lanzhou, 730000, China; The First Clinical Medical College, Lanzhou University, Lanzhou, 730000, China; Department of Respiratory, Lanzhou Lung Hospital, Lanzhou, 730000, China; Department of Radiology, The First Hospital of Lanzhou University, Lanzhou, 730000, China","Lin, C., Department of Radiology, Lanzhou Lung Hospital, Lanzhou, 730000, China, Gansu Provincial Infectious Disease Hospital, Lanzhou, 730000, China, The First Clinical Medical College, Lanzhou University, Lanzhou, 730000, China; Ding, Y., Department of Radiology, Lanzhou Lung Hospital, Lanzhou, 730000, China, Gansu Provincial Infectious Disease Hospital, Lanzhou, 730000, China; Xie, B., Department of Radiology, Lanzhou Lung Hospital, Lanzhou, 730000, China, Gansu Provincial Infectious Disease Hospital, Lanzhou, 730000, China; Sun, Z., Department of Radiology, Lanzhou Lung Hospital, Lanzhou, 730000, China, Gansu Provincial Infectious Disease Hospital, Lanzhou, 730000, China; Li, X., Gansu Provincial Infectious Disease Hospital, Lanzhou, 730000, China, Department of Respiratory, Lanzhou Lung Hospital, Lanzhou, 730000, China; Chen, Z., Department of Radiology, The First Hospital of Lanzhou University, Lanzhou, 730000, China; Niu, M., Department of Radiology, The First Hospital of Lanzhou University, Lanzhou, 730000, China","The purpose of this case report is to describe the imaging and associated clinical features of an asymptomatic novel coronavirus pneumonia (COVID-19) patient outside Wuhan, China. The principle findings are that in this patient with laboratory-confirmed COVID-19, CT findings preceded symptoms and included bilateral pleural effusions, previously not reported in association with COVID-19. The role of this case report is promotion of potential recognition amongst radiologists of this new disease, which has been declared a global health emergency by the World Health Organization (WHO). © 2020",2019-nCoV; COVID-19; Ground glass opacities; Novel coronavirus pneumonia; Pleural effusion,2019-nCoV; Coronaviruses; COVID-19; Ground-glass opacity; Pleural effusion; Computerized tomography; C reactive protein; interferon; lopinavir plus ritonavir; methylprednisolone; adult; Article; asymptomatic infection; case report; Chinese; clinical article; coronavirus disease 2019; Coronavirus infection; dyspnea; ground glass opacity; high resolution computer tomography; human; lung lesion; male; middle aged; nucleic acid analysis; pleura effusion; priority journal; radiological parameters; throat culture; virus pneumonia,"Center for Disease Control and Prevention (CDC), Locations with confirmed COVID-19 cases https://www.cdc.gov/coronavirus/2019-ncov/locations-confirmed-cases.html, (Accessed 15 February 2020); Center for Disease Control and Prevention (CDC), Coronavirus disease 2019 (COVID-19) situation report-25 https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200214-sitrep-25-covid-19.pdf?sfvrsn=61dda7d_2, (Accessed 15 February 2020); Center for Disease Control and Prevention (CDC), Coronavirus disease 2019 (COVID-19) in the U.S https://www.cdc.gov/coronavirus/2019-ncov/cases-in-us.html, (Accessed 15 February 2020); PubMed search on novel coronavirus pneumonia AND radiology https://www.ncbi.nlm.nih.gov/pubmed/?term=novel+coronavirus+pneumonia+AND+radiology, (Accessed 15 February 2020); Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, , [pii: S0140-6736(20)30183-5, Epub ahead of print]; Pan, Y., Guan, H., Zhou, S., Initial CT findings and temporal changes in patients with the novel coronavirus pneumonia (2019-nCoV): a study of 63 patients in Wuhan (2020) China Eur Radiol; Pan, F., Ye, T., Sun, P., Time course of lung changes on chest CT during recovery from 2019 novel coronavirus (COVID-19) pneumonia (2020) Radiology, 13, p. 200370. , [Epub ahead of print]; Xie, X., Zhong, Z., Zhao, W., Chest CT for typical 2019-nCoV pneumonia: relationship to negative RT-PCR testing (2020) Radiology, p. 200343. , [Epub ahead of print]; Vandenbroucke, J., In defense of case reports and case series (2001) Ann Intern Med, 134, pp. 330-334","Lin, C.; Department of Radiology, Lanzhou Lung Hospital, No. 968, North Riverside Middle Road, Chengguan District, China; email: 1204731562@qq.com",,Elsevier Inc.,8997071,,CLIME,,English,Clin. Imaging,Article,Final,Open Access,Scopus,2-s2.0-85080037652,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Lippi G., Plebani M., Henry B.M.",57205413642;57202559706;56689347500;,Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis,2020,Clinica Chimica Acta,506,,,145,148,,,10.1016/j.cca.2020.03.022,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082406821&doi=10.1016%2fj.cca.2020.03.022&partnerID=40&md5=0ed73c1220ee1af3e34e846fd39540d8,"Section of Clinical Biochemistry, Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy; Department of Laboratory Medicine, University Hospital of Padova, Padova, Italy; Cardiac Intensive Care Unit, The Heart Institute, Cincinnati Children's Hospital Medical CenterOH, United States","Lippi, G., Section of Clinical Biochemistry, Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy; Plebani, M., Department of Laboratory Medicine, University Hospital of Padova, Padova, Italy; Henry, B.M., Cardiac Intensive Care Unit, The Heart Institute, Cincinnati Children's Hospital Medical CenterOH, United States","Background: Coronavirus disease 2019 (COVID-19) is a novel infectious disease with lack of established laboratory markers available to evaluate illness severity. In this study, we investigate whether platelet count could differentiate between COVID-19 patients with or without severe disease. Additionally, we evaluate if thrombocytopenia is associated with severe COVID-19. Methods: An electronic search in Medline, Scopus and Web of Science was performed to identify studies reporting data on platelet count in COVID-19 patients. A meta-analysis was performed, with calculation of weighted mean difference (WMD) of platelet number in COVID-19 patients with or without severe disease and odds ratio (OR) of thrombocytopenia for severe form of COVID-19. Results: Nine studies with 1779 COVID-19 patients, 399 (22.4%) with severe disease, were included in the meta-analysis. The pooled analysis revealed that platelet count was significantly lower in patients with more severe COVID-19 (WMD −31 × 109/L; 95% CI, from −35 to −29 × 109/L). A subgroup analysis comparing patients by survival, found an even lower platelet count was observed with mortality (WMD, −48 × 109/L; 95% CI, −57 to −39 × 109/L. In the four studies (n = 1427) which reported data on rate of thrombocytopenia, a low platelet count was associated with over fivefold enhanced risk of severe COVID-19 (OR, 5.1; 95% CI, 1.8–14.6). Conclusions: Low platelet count is associated with increased risk of severe disease and mortality in patients with COVID-19, and thus should serve as clinical indicator of worsening illness during hospitalization. © 2020 Elsevier B.V.","Coronavirus, COVID-19; Platelets; Thrombocytopenia",,"(2020), https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200307-sitrep-47-covid-19.pdf?sfvrsn=27c364a4_2, World Health Organization, Coronavirus disease 2019 (COVID-19) Situation Report – 47. (accessed March 7, 2020); (2020), https://www.who.int/docs/default-source/coronaviruse/who-china-joint-mission-on-covid-19-final-report.pdf, WHO-China Joint Mission, Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19). (accessed March 1, 2020); Mattiuzzi, C., Lippi, G., Which lessons shall we learn from the 2019 novel coronavirus outbreak? (2020) Ann. Transl. Med., 8. , http://atm.amegroups.com/post/view/which-lessons-shall-we-learn-from-the-2019-novel-coronavirus-outbreak, (accessed March 8, 2020); Khurana, D., Deoke, S.A., Thrombocytopenia in critically Ill patients: clinical and laboratorial behavior and its correlation with short-term outcome during hospitalization (2017) Indian J. Crit. Care Med., 21, pp. 861-864; Vanderschueren, S., De Weerdt, A., Malbrain, M., Vankersschaever, D., Frans, E., Wilmer, A., Bobbaers, H., Thrombocytopenia and prognosis in intensive care (2000) Crit. Care Med., 28, pp. 1871-1876; Hui, P., Cook, D.J., Lim, W., Fraser, G.A., Arnold, D.M., The frequency and clinical significance of thrombocytopenia complicating critical illness: a systematic review (2011) Chest, 139, pp. 271-278; Yang, M., Ng, M.H.L., Li, C.K., Thrombocytopenia in patients with severe acute respiratory syndrome (review) (2005) Hematology, 10, pp. 101-105; He, W., Chen, S., Liu, X., Li, Y., Xiao, Z., Zhong, N., Death risk factors of severe acute respiratory syndrome with acute respiratory distress syndrome (2003) Chin. Crit. Care Med., 15, pp. 336-337; Zou, Z., Yang, Y., Chen, J., Xin, S., Zhang, W., Zhou, X., Mao, Y., Liu, X., Prognostic factors for severe acute respiratory syndrome: a clinical analysis of 165 cases (2004) Clin. Infect. Dis., 38, pp. 483-489; Hozo, S.P., Djulbegovic, B., Hozo, I., Estimating the mean and variance from the median, range, and the size of a sample (2005) BMC Med. Res. Method., 5, p. 13; Guan, W.-J., Ni, Z.-Y., Hu, Y., Liang, W.-H., Ou, C.-Q., He, J.-X., Liu, L., Zhong, N.-S., China medical treatment expert group for covid-19, clinical characteristics of coronavirus disease 2019 in China (2020) N. Engl. J. Med.; Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Cao, B., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) The Lancet., 395, pp. 497-506. , https://doi.org/10.1016/S0140-6736(20)30183-5; Liu, W., Tao, Z.-W., Lei, W., Ming-Li, Y., Kui, L., Ling, Z., Shuang, W., Yi, H., Analysis of factors associated with disease outcomes in hospitalized patients with 2019 novel coronavirus disease (2020) Chin. Med. J.; Liu, Y., Yang, Y., Zhang, C., Huang, F., Wang, F., Yuan, J., Wang, Z., Liu, L., Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury (2020) Sci. China Life Sci., 63, pp. 364-374; Ruan, Q., Yang, K., Wang, W., Jiang, L., Song, J., Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China (2020) Intensive Care Med.; Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Wang, B., Peng, Z., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) JAMA; Yang, X., Yu, Y., Xu, J., Shu, H., Xia, J., Liu, H., Wu, Y., Shang, Y., Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study (2020) Lancet Respirat. Med.; Young, B.E., Ong, S.W.X., Kalimuddin, S., Low, J.G., Tan, S.Y., Loh, J., Ng, O.-T., Lye, D.C., Epidemiologic Features and clinical course of patients infected with SARS-CoV-2 in Singapore (2020) JAMA; Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., Xiang, J., Cao, B., Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study (2020) Lancet; Zarychanski, R., Houston, D.S., Assessing thrombocytopenia in the intensive care unit: the past, present, and future (2017) Hematol. Am. Soc. Hematol. Educ. Program., 2017, pp. 660-666; Jolicoeur, P., Lamontagne, L., Impairment of bone marrow pre-B and B cells in MHV3 chronically-infected mice (1995) Adv. Exp. Med. Biol., 380, pp. 193-195; Lippi, G., Plebani, M., Procalcitonin in patients with severe coronavirus disease 2019 (COVID-19): a meta-analysis (2020) Clin. Chim. Acta","Henry, B.M.; Cardiac Intensive Care Unit, The Heart Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, United States; email: Brandon.henry@cchmc.org",,Elsevier B.V.,98981,,CCATA,32178975,English,Clin. Chim. Acta,Article,Final,Open Access,Scopus,2-s2.0-85082406821,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, Phan T.,57213171090;,Genetic diversity and evolution of SARS-CoV-2,2020,"Infection, Genetics and Evolution",81,,104260,,,,,10.1016/j.meegid.2020.104260,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079863367&doi=10.1016%2fj.meegid.2020.104260&partnerID=40&md5=23b9b8c5de23c7213b2351132513f0d7,"Division of Clinical Microbiology, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, United States","Phan, T., Division of Clinical Microbiology, University of Pittsburgh and University of Pittsburgh Medical Center, Pittsburgh, PA, United States",COVID-19 is a viral respiratory illness caused by a new coronavirus called SARS-CoV-2. The World Health Organization declared the SARS-CoV-2 outbreak a global public health emergency. We performed genetic analyses of eighty-six complete or near-complete genomes of SARS-CoV-2 and revealed many mutations and deletions on coding and non-coding regions. These observations provided evidence of the genetic diversity and rapid evolution of this novel coronavirus. © 2020 Elsevier B.V.,Coronavirus; Genomic diversity; Mutations; SARS-CoV-2,article; gene deletion; genetic analysis; genetic variability; nonhuman; SARS coronavirus,"Bastola, A., Sah, R., Rodriguez-Morales, A.J., Lal, B.K., Jha, R., Ojha, H.C., Shrestha, B., Pandey, B.D., The first 2019 novel coronavirus case in Nepal (2020) Lancet Infect. Dis., , (pii: S1473-3099(20)300670), (in press), [Epub ahead of print]; Fung, T.S., Liu, D.X., Human coronavirus: host-pathogen interaction (2019) Annu. Rev. Microbiol., 73, pp. 529-557; To, K.K., Tsang, O.T., Chik-Yan, C.Y., Chan, K.H., Wu, T.C., Chan, J.M.C., Leung, W.S., Yuen, K.Y., Consistent detection of 2019 novel coronavirus in saliva (2020) Clin. Infect. Dis., , (pii: ciaa149); Lauring, A.S., Andino, R., Quasispecies theory and the behavior of RNA viruses (2010) PLoS Pathog., 6; Lin, X., Gong, Z., Xiao, Z., Xiong, J., Fan, B., Liu, J., Novel coronavirus pneumonia outbreak in 2019: Computed tomographic findings in two cases (2020) Korean J. Radiol.; Nishiura, H., Linton, N.M., Akhmetzhanov, A.R., Initial cluster of novel coronavirus (2019-nCoV) infections in Wuhan, China is consistent with substantial human-to-human transmission (2020) J. Clin. Med., 9. , pii: E488; Phan, T., Novel coronavirus: from discovery to clinical diagnostics (2020) Infect. Genet. Evol., 79, p. 104211; Saitou, N., Nei, M., The neighbor-joining method: a new method for reconstructing phylogenetic trees (1987) Mol. Biol. Evol., 4, pp. 406-425; Velavan, T.P., Meyer, C.G., The Covid-19 epidemic (2020) Tropical Med. Int. Health; Yu, F., Du, L., Ojcius, D.M., Pan, C., Jiang, S., Measures for diagnosing and treating infections by a novel coronavirus responsible for a pneumonia outbreak originating in Wuhan, China (2020) Microbes Infect., , pii: S1286-4579(20)300253; Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., Zhao, X., Investigating, C.N.C., Research Team. A novel coronavirus from patients with pneumonia in China (2019) N. Engl. J. Med., p. 2020","Phan, T.; Division of Clinical Microbiology, University of Pittsburgh and University of Pittsburgh Medical CenterUnited States; email: phantg@upmc.edu",,Elsevier B.V.,15671348,,IGENC,,English,Infec. Genet. Evol.,Article,Final,Open Access,Scopus,2-s2.0-85079863367,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Fahmi M., Kubota Y., Ito M.",57205712674;57215588272;55726712200;,Nonstructural proteins NS7b and NS8 are likely to be phylogenetically associated with evolution of 2019-nCoV,2020,"Infection, Genetics and Evolution",81,,104272,,,,,10.1016/j.meegid.2020.104272,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081227123&doi=10.1016%2fj.meegid.2020.104272&partnerID=40&md5=8746c7d6cb00519ec9e2c4757f91e719,"Advanced Life Sciences Program, Graduate School of Life Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga 525-8577, Japan; Department of Bioinformatics, College of Life Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga 525-8577, Japan","Fahmi, M., Advanced Life Sciences Program, Graduate School of Life Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga 525-8577, Japan; Kubota, Y., Department of Bioinformatics, College of Life Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga 525-8577, Japan; Ito, M., Advanced Life Sciences Program, Graduate School of Life Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga 525-8577, Japan, Department of Bioinformatics, College of Life Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu, Shiga 525-8577, Japan","The seventh novel human infecting Betacoronavirus that causes pneumonia (2019 novel coronavirus, 2019-nCoV) originated in Wuhan, China. The evolutionary relationship between 2019-nCoV and the other human respiratory illness-causing coronavirus is not closely related. We sought to characterize the relationship of the translated proteins of 2019-nCoV with other species of Orthocoronavirinae. A phylogenetic tree was constructed from the genome sequences. A cluster tree was developed from the profiles retrieved from the presence and absence of homologs of ten 2019-nCoV proteins. The combined data were used to characterize the relationship of the translated proteins of 2019-nCoV to other species of Orthocoronavirinae. Our analysis reliably suggests that 2019-nCoV is most closely related to BatCoV RaTG13 and belongs to subgenus Sarbecovirus of Betacoronavirus, together with SARS coronavirus and Bat-SARS-like coronavirus. The phylogenetic profiling cluster of homolog proteins of one annotated 2019-nCoV protein against other genome sequences revealed two clades of ten 2019-nCoV proteins. Clade 1 consisted of a group of conserved proteins in Orthocoronavirinae comprising Orf1ab polyprotein, Nucleocapsid protein, Spike glycoprotein, and Membrane protein. Clade 2 comprised six proteins exclusive to Sarbecovirus and Hibecovirus. Two of six Clade 2 nonstructural proteins, NS7b and NS8, were exclusively conserved among 2019-nCoV, BetaCoV_RaTG, and BatSARS-like Cov. NS7b and NS8 have previously been shown to affect immune response signaling in the SARS-CoV experimental model. Thus, we speculated that knowledge of the functional changes in the NS7b and NS8 proteins during evolution may provide important information to explore the human infective property of 2019-nCoV. © 2020 The Authors",2019-nCoV; Novel proteins; Phylogenetic profile; Phylogenetic tree,nonstructural protein NS7b; nonstructural protein NS8; unclassified drug; viral protein; Article; Bat SARS like coronavirus; Betacoronavirus; cladistics; Coronavirinae; evolution; gene sequence; Hibecovirus; nonhuman; phylogeny; priority journal; Sarbecovirus; SARS coronavirus; SARS-related coronavirus; sequence homology; Severe acute respiratory syndrome coronavirus 2; virus genome,"Camacho, C., Coulouris, G., Avagyan, V., BLAST+: architecture and applications (2009) BMC Bioinform., 10 (1), p. 421; Cui, J., Li, F., Shi, Z.L., Origin and evolution of pathogenic coronaviruses (2019) Nat. Rev. Microbiol., 17, pp. 181-192; Darriba, D., Posada, D., Kozlov, A.M., ModelTest-NG: a new and scalable tool for the selection of DNA and protein evolutionary models (2020) Mol. Biol. Evol., 37 (1), pp. 291-294; Drozdetskiy, A., Cole, C., Procter, J., JPred4: a protein secondary structure prediction server (2015) Nucleic Acids Res., 43, pp. W389-W394; Federhen, S., The NCBI taxonomy database (2012) Nucleic Acids Res., 40 (D1), pp. D136-D143; Forni, D., Cagliani, R., Clerici, M., Molecular evolution of human coronavirus genomes (2017) Trends Microbiol., 25, pp. 35-48; Fukuchi, S., Amemiya, T., Sakamoto, S., IDEAL in 2014 illustrates interaction networks composed of intrinsically disordered proteins and their binding partners (2014) Nucleic Acids Res., 42, pp. D320-D325; Katoh, K., Standley, D.M., MAFFT multiple sequence alignment software version 7: improvements in performance and usability (2013) Mol. Biol. Evol., 30 (4), pp. 772-780; Kumar, S., Stecher, G., Li, M., MEGA X: molecular evolutionary genetics analysis across computing platforms (2018) Mol. Biol. Evol., 35 (6), pp. 1547-1549; Lee, J.Y., Bae, S., Myoung, J., Middle East respiratory syndrome coronavirus-encoded accessory proteins impair MDA5-and TBK1-mediated activation of NF-κB (2019) J. Microbiol. Biotechnol., 29 (8), pp. 1316-1323; Lee, J.Y., Bae, S., Myoung, J., Middle East respiratory syndrome coronavirus-encoded ORF8b strongly antagonizes IFN-β promoter activation: its implication for vaccine design (2019) J. Microbiol., 57 (9), pp. 803-811; Lu, R., Zhao, X., Li, J., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet., S0140-6736 (20), pp. 30251-30258; Luk, H.K.H., Li, X., Fung, J., Molecular epidemiology, evolution, and phylogeny of SARS coronavirus (2019) Infect. Genet. 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Evol., 104212; Pfefferle, S., Krähling, V., Ditt, V., Reverse genetic characterization of the natural genomic deletion in SARS-coronavirus strain Frankfurt-1 open reading frame 7b reveals an attenuating function of the 7b protein in-vitro and in-vivo (2009) Virol. J., 6 (1), p. 131; Pruitt, K.D., Tatusova, T., Maglott, D.R., NCBI reference sequences (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins (2007) Nucleic Acids Res., 35, pp. D61-D65; Ramadan, N., Shaib, H., Middle East respiratory syndrome coronavirus (MERS-CoV): a review (2019) Germs, 9, pp. 35-42; Schaecher, S.R., Mackenzie, J.M., Pekosz, A., The ORF7b protein of severe acute respiratory syndrome coronavirus (SARS-CoV) is expressed in virus-infected cells and incorporated into SARS-CoV particles (2007) J. Virol., 81 (2), pp. 718-731; Stamatakis, A., RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models (2006) Bioinformatics, 22 (21), pp. 2688-2690; Su, S., Epidemiology, genetic recombination, and pathogenesis of coronaviruses (2016) Trends Microbiol., 24, pp. 490-502; Ward, J.H., Jr., Hierarchical grouping to optimize an objective function (1963) J. Am. Stat. Assoc., 58 (301), pp. 236-244; Weiss, S.R., Leibowitz, J.L., Coronavirus pathogenesis (2011) Adv. Virus Res., 81, pp. 85-164; Wong, H.H., Fung, T.S., Fang, S., Accessory proteins 8b and 8ab of severe acute respiratory syndrome coronavirus suppress the interferon signaling pathway by mediating ubiquitin-dependent rapid degradation of interferon regulatory factor 3 (2018) Virology, 515, pp. 165-175; Woo, P.C., Discovery of seven novel mammalian and avian coronaviruses in the genus deltacoronavirus supports bat coronaviruses as the gene source of alphacoronavirus and betacoronavirus and avian coronaviruses as the gene source of gammacoronavirus and deltacoronavirus (2012) J. Virol., 86, pp. 3995-4008; Zhang, C., Mortuza, S.M., He, B., Wang, Y., Zhang, Y., Template-based and free modeling of I-TASSER and QUARK pipelines using predicted contact maps in CASP12 (2018) Proteins, 86, pp. 136-151; Zhou, P., Yang, X.L., Wang, X.G., A pneumonia outbreak associated with a new coronavirus of probable vat origin (2020) Nature.","Ito, M.; Advanced Life Sciences Program, Graduate School of Life Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Japan; email: maito@sk.ritsumei.ac.jp",,Elsevier B.V.,15671348,,IGENC,32142938,English,Infec. Genet. Evol.,Article,Final,Open Access,Scopus,2-s2.0-85081227123,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Lv D.-F., Ying Q.-M., Weng Y.-S., Shen C.-B., Chu J.-G., Kong J.-P., Sun D.-H., Gao X., Weng X.-B., Chen X.-Q.",57215060677;57216035801;55509077800;57216037269;57216038603;57216041744;57215071380;57215069679;35590916800;57209322960;,Dynamic change process of target genes by RT-PCR testing of SARS-Cov-2 during the course of a Coronavirus Disease 2019 patient,2020,Clinica Chimica Acta,506,,,172,175,,,10.1016/j.cca.2020.03.032,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082512838&doi=10.1016%2fj.cca.2020.03.032&partnerID=40&md5=1ef98261537c672fd47f07555f3327fa,"Department of Blood Transfusion, Ningbo First Hospital, Ningbo, China; Department of Blood Transfusion, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo, China; Department of Laboratory Medicine, Ningbo First Hospital, Ningbo, China; Department of Laboratory Medicine, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo, China; Department of General Practice, Ningbo First Hospital, Ningbo, China; Department of General Practice, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo, China; Department of Neurosurgery, Ningbo First Hospital, Ningbo, China; Department of Neurosurgery, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo, China; Department of Chinese Traditional Medicine, Ningbo First Hospital, Ningbo, China; Department of Chinese Traditional Medicine, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo, China","Lv, D.-F., Department of Blood Transfusion, Ningbo First Hospital, Ningbo, China, Department of Blood Transfusion, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo, China, Department of Laboratory Medicine, Ningbo First Hospital, Ningbo, China, Department of Laboratory Medicine, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo, China; Ying, Q.-M., Department of Blood Transfusion, Ningbo First Hospital, Ningbo, China, Department of Blood Transfusion, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo, China; Weng, Y.-S., Department of Laboratory Medicine, Ningbo First Hospital, Ningbo, China, Department of Laboratory Medicine, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo, China; Shen, C.-B., Department of Laboratory Medicine, Ningbo First Hospital, Ningbo, China, Department of Laboratory Medicine, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo, China; Chu, J.-G., Department of General Practice, Ningbo First Hospital, Ningbo, China, Department of General Practice, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo, China; Kong, J.-P., Department of Laboratory Medicine, Ningbo First Hospital, Ningbo, China, Department of Laboratory Medicine, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo, China; Sun, D.-H., Department of Laboratory Medicine, Ningbo First Hospital, Ningbo, China, Department of Laboratory Medicine, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo, China; Gao, X., Department of Neurosurgery, Ningbo First Hospital, Ningbo, China, Department of Neurosurgery, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo, China; Weng, X.-B., Department of Laboratory Medicine, Ningbo First Hospital, Ningbo, China, Department of Laboratory Medicine, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo, China; Chen, X.-Q., Department of Chinese Traditional Medicine, Ningbo First Hospital, Ningbo, China, Department of Chinese Traditional Medicine, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo, China","We report the dynamic change process of target genes by RT-PCR testing of SARS-Cov-2 during the course of a COVID-19 patient: from successive negative results to successive single positive nucleocapsid gene, to two positive target genes (orf1ab and nucleocapsid) by RT-PCR testing of SARS-Cov-2, and describe the diagnosis, clinical course, and management of the case. In this case, negative results of RT-PCR testing was not excluded to diagnose a suspected COVID-19 patient, clinical signs and symptoms, other laboratory findings, and chest CT images should be taken into account for the absence of enough positive evidence. This case highlights the importance of successive sampling and testing SARS-Cov-2 by RT-PCR as well as the increased value of single positive target gene from pending to positive in two specimens to diagnose laboratory-confirmed COVID-19. © 2020",Coronavirus; COVID-19; Nucleocapsid; RT-PCR testing; SARS-Cov-2,,"https://www.who.int/csr/don/12-january-2020-novel-coronavirus-china/en/, World Health Organization. Novel coronavirus- China. 2020 (); Lu, R., Zhao, X., Li, J., Genomic characterisation and epidemiology of novel coronavirus: implications for virus origins and receptor binding (2020) Lancet; Schoeman, D., Fielding, B.C., (2019), http://doi.org/10.1186/s12985-019-1182-0, Coronavirus envelope protein: current knowledge. Virol. J. 16 (1) 69; Saminathan, M., Chakraborty, S., Tiwari, R., Coronavirus infection in equines: a review (2014) Asian J. Anim. Vet. Adv., 9, pp. 164-176; Zhu, N., Zhang, D., Wang, W., A Novel Coronavirus from Patients with Pneumonia in China, 2019 (2020) N. Engl. J. Med., 382 (8), pp. 727-733; Zhang, Y.Z., Initial genome release of novel coronavirus (2020), http://virological.org/t/initial-genome-release-of-novel-coronavirus/319?from=groupmessage; Wu, F., Zhao, S., Yu, B., A new coronavirus associated with human respiratory disease in China (2020) Nature; General Office of National Health Commission PRC. Guidelines of prevention and control of COVID-19 [M]. 2020. The fifth edition; General Office of National Health Commission PRC. Guidelines of prevention and control of COVID-19 [M]. 2020. The fourth edition; General Office of National Health Commission PRC. Guidelines of diagnosis and treatment of COVID-19 [M]. 2020. The sixth edition; Guan, W.-J., Zheng-yi Ni, Y., Clinical Characteristics of Coronavirus Disease 2019 in China (2020) N. Engl. J. Med.","Weng, X.-B.; Department of Laboratory Medicine, Ningbo First HospitalChina; email: wxb6006@hotmail.com",,Elsevier B.V.,98981,,CCATA,,English,Clin. Chim. Acta,Article,Final,,Scopus,2-s2.0-85082512838,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wang P., Chen K., Zhu S., Wang P., Zhang H.",57204181688;57203428720;57215876191;57191962916;8385769600;,Severe air pollution events not avoided by reduced anthropogenic activities during COVID-19 outbreak,2020,"Resources, Conservation and Recycling",158,,104814,,,,,10.1016/j.resconrec.2020.104814,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082178451&doi=10.1016%2fj.resconrec.2020.104814&partnerID=40&md5=a7d801f5d18bc07c3eae7acc478d5eb5,"Department of Environmental Science and Engineering, Fudan University, Shanghai, 200438, China; Department of Civil and Environmental Engineering, Louisiana State University, Baton Rouge, LA 70803, United States; Department of Civil and Environmental Engineering, Hong Kong Polytechnic UniversityHong Kong 99907, China; Institute of Eco-Chongming (SIEC), Shanghai, 200062, China","Wang, P., Department of Environmental Science and Engineering, Fudan University, Shanghai, 200438, China, Department of Civil and Environmental Engineering, Louisiana State University, Baton Rouge, LA 70803, United States; Chen, K., Department of Civil and Environmental Engineering, Louisiana State University, Baton Rouge, LA 70803, United States; Zhu, S., Department of Environmental Science and Engineering, Fudan University, Shanghai, 200438, China; Wang, P., Department of Civil and Environmental Engineering, Hong Kong Polytechnic UniversityHong Kong 99907, China; Zhang, H., Department of Environmental Science and Engineering, Fudan University, Shanghai, 200438, China, Department of Civil and Environmental Engineering, Louisiana State University, Baton Rouge, LA 70803, United States, Institute of Eco-Chongming (SIEC), Shanghai, 200062, China","Due to the pandemic of coronavirus disease 2019 in China, almost all avoidable activities in China are prohibited since Wuhan announced lockdown on January 23, 2020. With reduced activities, severe air pollution events still occurred in the North China Plain, causing discussions regarding why severe air pollution was not avoided. The Community Multi-scale Air Quality model was applied during January 01 to February 12, 2020 to study PM2.5 changes under emission reduction scenarios. The estimated emission reduction case (Case 3) better reproduced PM2.5. Compared with the case without emission change (Case 1), Case 3 predicted that PM2.5 concentrations decreased by up to 20% with absolute decreases of 5.35, 6.37, 9.23, 10.25, 10.30, 12.14, 12.75, 14.41, 18.00 and 30.79 μg/m3 in Guangzhou, Shanghai, Beijing, Shijiazhuang, Tianjin, Jinan, Taiyuan, Xi'an, Zhengzhou, Wuhan, respectively. In high-pollution days with PM2.5 greater than 75 μg/m3, the reductions of PM2.5 in Case 3 were 7.78, 9.51, 11.38, 13.42, 13.64, 14.15, 14.42, 16.95 and 22.08 μg/m3 in Shanghai, Jinan, Shijiazhuang, Beijing, Taiyuan, Xi'an, Tianjin, Zhengzhou and Wuhan, respectively. The reductions in emissions of PM2.5 precursors were ~2 times of that in concentrations, indicating that meteorology was unfavorable during simulation episode. A further analysis shows that benefits of emission reductions were overwhelmed by adverse meteorology and severe air pollution events were not avoided. This study highlights that large emissions reduction in transportation and slight reduction in industrial would not help avoid severe air pollution in China, especially when meteorology is unfavorable. More efforts should be made to completely avoid severe air pollution. © 2020 Elsevier B.V.",China; COVID-19; Emission reduction; Meteorology; Severe air pollution,air quality; atmospheric pollution; concentration (composition); COVID-19; emission control; human activity; meteorology; particulate matter; viral disease; China; North China Plain; Coronavirus,"Cai, S., Wang, Y., Zhao, B., Wang, S., Chang, X., Hao, J., The impact of the “air pollution prevention and control action plan” on PM2. 5 concentrations in Jing-Jin-Ji region during 2012–2020 (2017) Sci. Total Environ., 580, pp. 197-209; Cai, Z., Jiang, F., Chen, J., Jiang, Z., Wang, X., Weather condition dominates regional PM2.5 Pollutions in the Eastern Coastal Provinces of China during Winter (2018) Aerosol Air Qual. Res., 18 (4), pp. 969-980; Cao, J., Yang, C., Li, J., Chen, R., Chen, B., Gu, D., Kan, H., Association between long-term exposure to outdoor air pollution and mortality in China: a cohort study (2011) J. Hazard. 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Total Environ., 571, pp. 855-861; Cheng, Z., Wang, S., Jiang, J., Fu, Q., Chen, C., Xu, B., Yu, J., Hao, J., Long-term trend of haze pollution and impact of particulate matter in the Yangtze River Delta, China (2013) Environ. Pollut., 182, pp. 101-110; China, M., http://english.mee.gov.cn/Resources/Reports/soe/SOEE2017/201808/P020180801597738742758.pdf, o. E. a. E. o. t. P. s. R. o.2019a. 2017 Report on the state of the ecology and environment in China; China, S., http://www.gov.cn/zwgk/2013-09/12/content_2486773.htm, C. o. t. P. s. R. o.2019b. Notice of the general office of the state council on issuing the air pollution prevention and control action plan; https://mp.weixin.qq.com/s/aXdAEDuLL30XxWB1lA1f6A, CRAES2020. [Expert's Interpretation] This is a tough battle and a protracted battle—Understanding the causes of pollution during the Spring Festival; Daily, E., Spring farming is busy at villages without epidemic (2020), http://www.xinhuanet.com/local/2020-03/01/c_1125645258.htm; Guidance on the use of models and other analyses for demonstrating attainment of air quality goals for ozone, PM2. 5, and regional haze. US Environmental Protection Agency (2007) Office Air Qual. Plan. Stand.; Fu, X., Wang, S., Zhao, B., Xing, J., Cheng, Z., Liu, H., Hao, J., Emission inventory of primary pollutants and chemical speciation in 2010 for the Yangtze River Delta region, China (2013) Atmos. Environ., 70, pp. 39-50; Guenther, A.B., Jiang, X., Heald, C.L., Sakulyanontvittaya, T., Duhl, T., Emmons, L.K., Wang, X., The model of emissions of gases and aerosols from Nature version 2.1 (MEGAN2.1): an extended and updated framework for modeling biogenic emissions (2012) Geosci. 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Phys.; Zheng, J., Zhang, L., Che, W., Zheng, Z., Yin, S., A highly resolved temporal and spatial air pollutant emission inventory for the Pearl River Delta region, China and its uncertainty assessment (2009) Atmos. Environ., 43 (32), pp. 5112-5122","Zhang, H.; Department of Environmental Science and Engineering, Fudan UniversityChina; email: zhanghl@fudan.edu.cn",,Elsevier B.V.,9213449,,RCREE,,English,Resour. Conserv. Recycl.,Article,Final,Open Access,Scopus,2-s2.0-85082178451,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Li C., Yang Y., Ren L.",57215661895;57215670394;36159861300;,Genetic evolution analysis of 2019 novel coronavirus and coronavirus from other species,2020,"Infection, Genetics and Evolution",82,,104285,,,,,10.1016/j.meegid.2020.104285,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081593595&doi=10.1016%2fj.meegid.2020.104285&partnerID=40&md5=479d18b7b3e010abcb6a72e6cb4acfe1,"College of Animal Sciences, Jilin University, Changchun, 130062, China; Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, Changchun, 130112, China; The Chinese Peoples' Liberation Army 964 Hospital, Changchun, China","Li, C., The Chinese Peoples' Liberation Army 964 Hospital, Changchun, China; Yang, Y., Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural Sciences, Changchun, 130112, China; Ren, L., College of Animal Sciences, Jilin University, Changchun, 130062, China","The Corona Virus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a Public Health Emergency of International Concern. However, so far, there are still controversies about the source of the virus and its intermediate host. Here, we found the novel coronavirus was closely related to coronaviruses derived from five wild animals, including Paguma larvata, Paradoxurus hermaphroditus, Civet, Aselliscus stoliczkanus and Rhinolophus sinicus, and was in the same branch of the phylogenetic tree. However, genome and ORF1a homology show that the virus is not the same coronavirus as the coronavirus derived from these five animals, whereas the virus has the highest homology with Bat coronavirus isolate RaTG13. © 2020",2019 Coronavirus disease (COVID-19); Genetic evolution; Genome; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Structural protein,single stranded RNA; Aselliscus stoliczkanus; Betacoronavirus; China; civet (animal); cladistics; Coronavirinae; genetic analysis; genetic similarity; health hazard; human; infection risk; Letter; molecular evolution; molecular phylogeny; nonhuman; open reading frame; Paguma larvata; Paradoxurus hermaphroditus; phylogenetic tree; priority journal; public health problem; Rhinolophus sinicus; risk assessment; SARS coronavirus; Severe acute respiratory syndrome coronavirus 2; virus genome; virus recombination; virus strain; virus transmission; wild animal; World Health Organization,"Association, S.E.G.f.C.o.t.E.o.N.C.P.o.t.C.P.M., An update on the epidemiological characteristics of novel coronavirus pneumonia(COVID-19) (2020) Zhonghua Liu Xing Bing Xue Za Zhi, 41, pp. 139-144; Ceraolo, C., Giorgi, F.M., Genomic variance of the 2019-nCoV coronavirus (2020) J. Med. Virol.; Guo, Q., Li, M., Wang, C., Wang, P., Fang, Z., Tan, J., Wu, S., Zhu, H., Host and infectivity prediction of Wuhan 2019 novel coronavirus using deep learning algorithm (2020) bioRxiv; Ji, W., Wang, W., Zhao, X., Zai, J., Li, X., Cross-species transmission of the newly identified coronavirus 2019-nCoV (2020) J. Med. Virol., 92, pp. 433-440; Jiang, S., Shi, Z.L., The first disease X is caused by a highly transmissible acute respiratory syndrome coronavirus (2020) Virol. Sin.; Lai, C.C., Shih, T.P., Ko, W.C., Tang, H.J., Hsueh, P.R., Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): the epidemic and the challenges (2020) Int. J. Antimicrob. Agents, 105924; Lam, T.T.-Y., Shum, M.H.-H., Zhu, H.-C., Tong, Y.-G., Ni, X.-B., Liao, Y.-S., Wei, W., Guan, Y., Identification of 2019-nCoV related coronaviruses in Malayan pangolins in southern China (2020) bioRxiv; Li, X., Zai, J., Zhao, Q., Nie, Q., Li, Y., Foley, B.T., Chaillon, A., Evolutionary history, potential intermediate animal host, and cross-species analyses of SARS-CoV-2 (2020) J. Med. Virol.; Liu, P., Jiang, J.-Z., Wan, X.-F., Hua, Y., Wang, X., Hou, F., Chen, J., Chen, J., Are pangolins the intermediate host of the 2019 novel coronavirus (2019-nCoV)? (2020) bioRxiv; Liu, Z., Xiao, X., Wei, X., Li, J., Yang, J., Tan, H., Zhu, J., Liu, L., Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS-CoV-2 (2020) J. Med. Virol.; Lu, R., Zhao, X., Li, J., Niu, P., Yang, B., Wu, H., Wang, W., Tan, W., Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet, 395, pp. 565-574; Paraskevis, D., Kostaki, E.G., Magiorkinis, G., Panayiotakopoulos, G., Sourvinos, G., Tsiodras, S., Full-genome evolutionary analysis of the novel corona virus (2019-nCoV) rejects the hypothesis of emergence as a result of a recent recombination event (2020) Infect. Genet. Evol., 79, p. 104212; Shen, Z., Xiao, Y., Kang, L., Ma, W., Shi, L., Zhang, L., Zhou, Z., Li, M., Genomic diversity of SARS-CoV-2 in coronavirus disease 2019 patients (2020) Clin. Infect. Dis.; Su, S., Li, X., Hao, H., Wang, X.-Y., Zhang, M.-M., Geng, H., Ma, M., Advances in research on SARS-CoV-2 (2020) J. Xi'an Jiaotong Univ.(Medical Sciences), 41 (preprint), pp. 1-7. , http://kns.cnki.net/kcms/detail/61.1399.R.20200224.0944.010.html; Xiao, K., Zhai, J., Feng, Y., Zhou, N., Zhang, X., Zou, J.-J., Li, N., Shen, Y., Isolation and characterization of 2019-nCoV-like coronavirus from Malayan pangolins (2020) bioRxiv; Yang, Y., Chen, S., Ren, L., Genetic evolution analysis of Marten coronavirus and 2019 novel coronavirus (2020) Chin. J. Anim. Health Inspection, 37. , Accepted; Zhang, C., Zheng, W., Huang, X., Bell, E.W., Zhou, X., Zhang, Y., Protein structure and sequence re-analysis of 2019-nCoV genome does not indicate snakes as its intermediate host or the unique similarity between its spike protein insertions and HIV-1 (2020) bioRxiv; Zhang, T., Wu, Q., Zhang, Z., Pangolin homology associated with 2019-nCoV (2020) bioRxiv; Zhao, W., Song, S., Chen, M., Zou, D., Ma, L., Ma, Y., Li, R., Bao, Y., The 2019 novel coronavirus resource (2020) Hereditas, 42, pp. 212-221; Zhou, P., Yang, X.L., Wang, X.G., Hu, B., Zhang, L., Zhang, W., Si, H.R., Shi, Z.L., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature.","Yang, Y.; Institute of Special Wild Economic Animals and Plants, Chinese Academy of Agricultural SciencesChina; email: m18043213639@163.com",,Elsevier B.V.,15671348,,IGENC,32169673,English,Infec. Genet. Evol.,Letter,Final,Open Access,Scopus,2-s2.0-85081593595,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Zhou Y., Hou Y., Shen J., Huang Y., Martin W., Cheng F.",57212213748;57210344609;57215833594;57215202606;57215095756;36514277000;,Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2,2020,Cell Discovery,6,1,14,,,,,10.1038/s41421-020-0153-3,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082021457&doi=10.1038%2fs41421-020-0153-3&partnerID=40&md5=7301cb30bcac95e0d1089895e6376a3d,"Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, United States; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44195, United States; Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, United States","Zhou, Y., Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, United States; Hou, Y., Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, United States; Shen, J., Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, United States; Huang, Y., Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, United States; Martin, W., Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, United States; Cheng, F., Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, United States, Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44195, United States, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, United States","Human coronaviruses (HCoVs), including severe acute respiratory syndrome coronavirus (SARS-CoV) and 2019 novel coronavirus (2019-nCoV, also known as SARS-CoV-2), lead global epidemics with high morbidity and mortality. However, there are currently no effective drugs targeting 2019-nCoV/SARS-CoV-2. Drug repurposing, representing as an effective drug discovery strategy from existing drugs, could shorten the time and reduce the cost compared to de novo drug discovery. In this study, we present an integrative, antiviral drug repurposing methodology implementing a systems pharmacology-based network medicine platform, quantifying the interplay between the HCoV–host interactome and drug targets in the human protein–protein interaction network. Phylogenetic analyses of 15 HCoV whole genomes reveal that 2019-nCoV/SARS-CoV-2 shares the highest nucleotide sequence identity with SARS-CoV (79.7%). Specifically, the envelope and nucleocapsid proteins of 2019-nCoV/SARS-CoV-2 are two evolutionarily conserved regions, having the sequence identities of 96% and 89.6%, respectively, compared to SARS-CoV. Using network proximity analyses of drug targets and HCoV–host interactions in the human interactome, we prioritize 16 potential anti-HCoV repurposable drugs (e.g., melatonin, mercaptopurine, and sirolimus) that are further validated by enrichment analyses of drug-gene signatures and HCoV-induced transcriptomics data in human cell lines. We further identify three potential drug combinations (e.g., sirolimus plus dactinomycin, mercaptopurine plus melatonin, and toremifene plus emodin) captured by the “Complementary Exposure” pattern: the targets of the drugs both hit the HCoV–host subnetwork, but target separate neighborhoods in the human interactome network. In summary, this study offers powerful network-based methodologies for rapid identification of candidate repurposable drugs and potential drug combinations targeting 2019-nCoV/SARS-CoV-2. © 2020, The Author(s).",,angiotensin receptor antagonist; antiinflammatory agent; antineoplastic agent; antivirus agent; dactinomycin; emodin; immunosuppressive agent; melatonin; mercaptopurine; nucleocapsid protein; rapamycin; selective estrogen receptor modulator; toremifene; virus envelope protein; Article; Coronaviridae; Coronavirinae; drug repositioning; human; nonhuman; nucleotide sequence; phylogeny; priority journal; protein protein interaction; Severe acute respiratory syndrome coronavirus 2; virus cell interaction; virus genome; virus morphology,"Zumla, A., Chan, J.F., Azhar, E.I., Hui, D.S., Yuen, K.Y., Coronaviruses—drug discovery and therapeutic options (2016) Nat. Rev. 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Med., 3, p. 96ra77. , COI: 1:CAS:528:DC%2BC3MXhtFOisL3K, PID: 21849665","Cheng, F.; Genomic Medicine Institute, Lerner Research Institute, Cleveland ClinicUnited States; email: chengf@ccf.org",,Springer Nature,20565968,,,,English,Cell Discov.,Article,Final,Open Access,Scopus,2-s2.0-85082021457,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wang H., Wang Z., Dong Y., Chang R., Xu C., Yu X., Zhang S., Tsamlag L., Shang M., Huang J., Wang Y., Xu G., Shen T., Zhang X., Cai Y.",57214057593;57215068608;57215070284;57215041618;57215047487;57215053228;57212232831;57210972131;36187413900;57211067288;57214776108;57215032813;36187496400;55715548900;55574192802;,"Phase-adjusted estimation of the number of Coronavirus Disease 2019 cases in Wuhan, China",2020,Cell Discovery,6,1,10,,,,1,10.1038/s41421-020-0148-0,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079799485&doi=10.1038%2fs41421-020-0148-0&partnerID=40&md5=0725368d73311c24c1244cd58bb3861a,"School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China; Department of Cancer Prevention, Shanghai Cancer Center, Fudan University, Shanghai, 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China; Department of Environmental and Occupational Health, School of Public Health, China Medical University, Shenyang, 110122, China; Sanlin Community Health Service Center, Shanghai, 200124, China; State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine (Shanghai), Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China; Research Laboratory of Clinical Virology, National Research Center for Translational Medicine (Shanghai), Rui-Jin Hospital, and Rui-Jin Hospital North, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China","Wang, H., School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China; Wang, Z., Department of Cancer Prevention, Shanghai Cancer Center, Fudan University, Shanghai, 200032, China, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China; Dong, Y., Department of Environmental and Occupational Health, School of Public Health, China Medical University, Shenyang, 110122, China; Chang, R., School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China; Xu, C., School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China; Yu, X., School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China; Zhang, S., School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China; Tsamlag, L., School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China; Shang, M., Sanlin Community Health Service Center, Shanghai, 200124, China; Huang, J., State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine (Shanghai), Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China; Wang, Y., School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China; Xu, G., School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China; Shen, T., School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China; Zhang, X., Research Laboratory of Clinical Virology, National Research Center for Translational Medicine (Shanghai), Rui-Jin Hospital, and Rui-Jin Hospital North, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China; Cai, Y., School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China","An outbreak of clusters of viral pneumonia due to a novel coronavirus (2019-nCoV/SARS-CoV-2) happened in Wuhan, Hubei Province in China in December 2019. Since the outbreak, several groups reported estimated R0 of Coronavirus Disease 2019 (COVID-19) and generated valuable prediction for the early phase of this outbreak. After implementation of strict prevention and control measures in China, new estimation is needed. An infectious disease dynamics SEIR (Susceptible, Exposed, Infectious, and Removed) model was applied to estimate the epidemic trend in Wuhan, China under two assumptions of Rt. In the first assumption, Rt was assumed to maintain over 1. The estimated number of infections would continue to increase throughout February without any indication of dropping with Rt = 1.9, 2.6, or 3.1. The number of infections would reach 11,044, 70,258, and 227,989, respectively, by 29 February 2020. In the second assumption, Rt was assumed to gradually decrease at different phases from high level of transmission (Rt = 3.1, 2.6, and 1.9) to below 1 (Rt = 0.9 or 0.5) owing to increasingly implemented public health intervention. Several phases were divided by the dates when various levels of prevention and control measures were taken in effect in Wuhan. The estimated number of infections would reach the peak in late February, which is 58,077–84,520 or 55,869–81,393. Whether or not the peak of the number of infections would occur in February 2020 may be an important index for evaluating the sufficiency of the current measures taken in China. 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Biol., 229, pp. 119-126. , COI: 1:STN:280:DC%2BD2c3nvV2msw%3D%3D; Qun, L., (2020) Notes from the Field: An Outbreak of NCIP (2019-Ncov) Infection in China—Wuhan, 2, pp. 79-80. , The 2019-nCoV Outbreak Joint Field Epidemiology Investigation Team, Hubei Province, 2019–2020, China CDC Weekly; Guan, W.-J., (2020) Clinical Characteristics of 2019 Novel Coronavirus Infection in China, , https://doi.org/10.1101/2020.02.06.20020974, medRxiv; Pooling High-Quality Medical Resources all over the Country to Win the Battle of Preventing and Controlling Epidemics, , http://www.hubei.gov.cn/zwgk/hbyw/hbywqb/202002/t20200211_2023527.shtml; Wuhan Huoshenshan Hospital was Completed Today, , http://www.wh.gov.cn/2019_web/whyw/202002/t20200202_304343.html; Wuhan Leishenshan Hospital Welcomed Its First Confirmed 2019-Ncov Patients, , http://www.hubei.gov.cn/zhuanti/2020/gzxxgzbd/qfqk/202002/t20200209_2022182.shtml","Cai, Y.; School of Public Health, Shanghai Jiao Tong University School of MedicineChina; email: caiyong202028@hotmail.com",,Springer Nature,20565968,,,,English,Cell Discov.,Article,Final,Open Access,Scopus,2-s2.0-85079799485,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Jang K.-J., Jeong S., Kang D.Y., Sp N., Yang Y.M., Kim D.-E.",57211564998;57203984117;57215722585;56080388100;57208531724;7409761789;,A high ATP concentration enhances the cooperative translocation of the SARS coronavirus helicase nsP13 in the unwinding of duplex RNA,2020,Scientific Reports,10,1,4481,,,,,10.1038/s41598-020-61432-1,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081714319&doi=10.1038%2fs41598-020-61432-1&partnerID=40&md5=f665a1f006336a280c69fc3c672656eb,"Department of Bioscience and Biotechnology, Konkuk University, Seoul, 05029, South Korea; Department of Pathology, School of Medicine, Institute of Biomedical Science and Technology (IBST), Konkuk University, Seoul, 05029, South Korea","Jang, K.-J., Department of Bioscience and Biotechnology, Konkuk University, Seoul, 05029, South Korea, Department of Pathology, School of Medicine, Institute of Biomedical Science and Technology (IBST), Konkuk University, Seoul, 05029, South Korea; Jeong, S., Department of Bioscience and Biotechnology, Konkuk University, Seoul, 05029, South Korea; Kang, D.Y., Department of Pathology, School of Medicine, Institute of Biomedical Science and Technology (IBST), Konkuk University, Seoul, 05029, South Korea; Sp, N., Department of Pathology, School of Medicine, Institute of Biomedical Science and Technology (IBST), Konkuk University, Seoul, 05029, South Korea; Yang, Y.M., Department of Pathology, School of Medicine, Institute of Biomedical Science and Technology (IBST), Konkuk University, Seoul, 05029, South Korea; Kim, D.-E., Department of Bioscience and Biotechnology, Konkuk University, Seoul, 05029, South Korea","Severe acute respiratory syndrome coronavirus nonstructural protein 13 (SCV nsP13), a superfamily 1 helicase, plays a central role in viral RNA replication through the unwinding of duplex RNA and DNA with a 5′ single-stranded tail in a 5′ to 3′ direction. Despite its putative role in viral RNA replication, nsP13 readily unwinds duplex DNA by cooperative translocation. Herein, nsP13 exhibited different characteristics in duplex RNA unwinding than that in duplex DNA. nsP13 showed very poor processivity on duplex RNA compared with that on duplex DNA. More importantly, nsP13 inefficiently unwinds duplex RNA by increasing the 5′-ss tail length. As the concentration of nsP13 increased, the amount of unwound duplex DNA increased and that of unwound duplex RNA decreased. The accumulation of duplex RNA/nsP13 complexes increased as the concentration of nsP13 increased. An increased ATP concentration in the unwinding of duplex RNA relieved the decrease in duplex RNA unwinding. Thus, nsP13 has a strong affinity for duplex RNA as a substrate for the unwinding reaction, which requires increased ATPs to processively unwind duplex RNA. Our results suggest that duplex RNA is a preferred substrate for the helicase activity of nsP13 than duplex DNA at high ATP concentrations. © 2020, The Author(s).",,,"Molecular evolution of the SARS coronavirus during the course of the SARS epidemic in China (2004) Sci., 303, pp. 1666-1669; Marra, M.A., The genome sequence of the SARS-associated coronavirus (2003) Sci., 300, pp. 1399-1404; Rota, P.A., Characterization of a novel coronavirus associated with severe acute respiratory syndrome (2003) Sci., 300, pp. 1394-1399; Ziebuhr, J., Snijder, E.J., Gorbalenya, A.E., Virus-encoded proteinases and proteolytic processing in the Nidovirales (2000) J. Gen. Virology, 81, pp. 853-879; Brierley, I., Digard, P., Inglis, S.C., Characterization of an efficient coronavirus ribosomal frameshifting signal: requirement for an RNA pseudoknot (1989) Cell, 57, pp. 537-547; Ivanov, K.A., Multiple enzymatic activities associated with severe acute respiratory syndrome coronavirus helicase (2004) J. 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Biochem., 250, pp. 47-54; Gwack, Y., Kim, D.W., Han, J.H., Choe, J., Characterization of RNA binding activity and RNA helicase activity of the hepatitis C virus NS3 protein (1996) Biochem. Biophys. Res. Commun., 225, pp. 654-659; Wang, A.H., Molecular structure of r(GCG)d(TATACGC): a DNA–RNA hybrid helix joined to double helical DNA (1982) Nat., 299, pp. 601-604; Sugimoto, N., Thermodynamic parameters to predict stability of RNA/DNA hybrid duplexes (1995) Biochem., 34, pp. 11211-11216; Chin, K., Sharp, K.A., Honig, B., Pyle, A.M., Calculating the electrostatic properties of RNA provides new insights into molecular interactions and function (1999) Nat. Struct. Biol., 6, pp. 1055-1061. , COI: 1:CAS:528:DyaK1MXnt1Gru78%3D; Kankia, B.I., Marky, L.A., DNA, RNA, and DNA/RNA oligomer duplexes: A comparative study of their stability, heat, hydration, and Mg(2+) binding properties (1999) J. Phys. Chem. B, 103, pp. 8759-8767; Jia, Z., Delicate structural coordination of the Severe Acute Respiratory Syndrome coronavirus Nsp13 upon ATP hydrolysis (2019) Nucleic Acids Res., 47, pp. 6538-6550; Levin, M.K., Gurjar, M.M., Patel, S.S., ATP binding modulates the nucleic acid affinity of hepatitis C virus helicase (2003) J. Biol. Chem., 278, pp. 23311-23316; Appleby, T.C., Visualizing ATP-Dependent RNA Translocation by the NS3 Helicase from HCV (2011) J. Mol. Biol., 405, pp. 1139-1153","Kim, D.-E.; Department of Bioscience and Biotechnology, Konkuk UniversitySouth Korea; email: kimde@konkuk.ac.kr",,Nature Research,20452322,,,32161317,English,Sci. Rep.,Article,Final,Open Access,Scopus,2-s2.0-85081714319,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Wang K., Zhao W., Li J., Shu W., Duan J.",57216036950;57216043013;57216041588;57211798177;36339224700;,"The experience of high-flow nasal cannula in hospitalized patients with 2019 novel coronavirus-infected pneumonia in two hospitals of Chongqing, China",2020,Annals of Intensive Care,10,1,37,,,,,10.1186/s13613-020-00653-z,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082536012&doi=10.1186%2fs13613-020-00653-z&partnerID=40&md5=970a5a2285edc8141388ce6b40eb7791,"Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China; Department of Oncology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China; Department of Thoracic Surgery, Chongqing Public Health Medical Center, Chongqing, 500106, China; Department of Critical Care Medicine, Yongchuan Hospital of Chongqing Medical University, Xuanhua Road 429, Yongchuan District, Chongqing, 402160, China; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Youyi Road 1, Yuzhong District, Chongqing, 400016, China","Wang, K., Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China; Zhao, W., Department of Oncology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China; Li, J., Department of Thoracic Surgery, Chongqing Public Health Medical Center, Chongqing, 500106, China; Shu, W., Department of Critical Care Medicine, Yongchuan Hospital of Chongqing Medical University, Xuanhua Road 429, Yongchuan District, Chongqing, 402160, China; Duan, J., Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Youyi Road 1, Yuzhong District, Chongqing, 400016, China","Background: The outbreak of a novel coronavirus (2019-nCoV)-infected pneumonia (NCIP) is currently ongoing in China. Most of the critically ill patients received high-flow nasal cannula (HFNC) oxygen therapy. However, the experience of HFNC in this population is lacking. Methods: We retrospectively screened 318 confirmed patients with NCIP in two hospitals of Chongqing, China, from January 1st to March 4th, 2020. Among them, 27 (8.4%) patients experienced severe acute respiratory failure including 17 patients (63%) treated with HFNC as first-line therapy, 9 patients (33%) treated with noninvasive ventilation (NIV) and one patient (4%) treated with invasive ventilation. HFNC failure was defined by the need of NIV or intubation as rescue therapy. Results: Of the 17 HFNC patients, 7 (41%) experienced HFNC failure. The HFNC failure rate was 0% (0/6) in patients with PaO2/FiO2 > 200 mm Hg vs. 63% (7/11) in those with PaO2/FiO2 ≤ 200 mm Hg (p = 0.04). Compared with baseline data, the respiratory rate significantly decreased after 1–2 h of HFNC in successful group [median 26 (IQR: 25–29) vs. 23 (22–25), p = 0.03]. However, it did not in the unsuccessful group. After initiation of NIV as rescue therapy among the 7 patients with HFNC failure, PaO2/FiO2 significantly improved after 1–2 h of NIV [median 172 (150–208) mmHg vs. 114 (IQR: 79–130) under HFNC, p = 0.04]. However, two out of seven (29%) patients with NIV as rescue therapy ultimately received intubation. Among the 27 patients with severe acute respiratory failure, four patients were eventually intubated (15%). Conclusions: Our study indicated that HFNC was the most common ventilation support for patients with NCIP. Patients with lower PaO2/FiO2 were more likely to experience HFNC failure. © 2020, The Author(s).",Coronavirus; High-flow nasal cannula; Pneumonia,,"Zhou, P., Yang, X.L., Wang, X.G., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature; Huang, C., Wang, Y., Li, X., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet; Chen, N., Zhou, M., Dong, X., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet; Wang, D., Hu, B., Hu, C., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China (2020) JAMA; Li, Q., Guan, X., Wu, P., Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia (2020) N Engl J Med; Chan, J.F., Yuan, S., Kok, K.H., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet; Yu, P., Zhu, J., Zhang, Z., A familial cluster of infection associated with the 2019 novel coronavirus indicating potential person-to-person transmission during the incubation period (2020) J Infect Dis; Holshue, M.L., DeBolt, C., Lindquist, S., Case, F., First case of 2019 novel coronavirus in the United States (2020) N Engl J Med; Kim, J.Y., Choe, P.G., Oh, Y., The first case of 2019 novel coronavirus pneumonia imported into Korea from Wuhan, China: implication for infection prevention and control measures (2020) J Korean Med Sci, 35; Silverstein, W.K., Stroud, L., Cleghorn, G.E., First imported case of 2019 novel coronavirus in Canada, presenting as mild pneumonia (2020) Lancet; Stoecklin, S.B., Rolland, P., Silue, Y., First cases of coronavirus disease 2019 (COVID-19) in France: surveillance, investigations and control measures, January 2020 (2020) Euro Surveill; The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China (2020) Zhonghua Liu Xing Bing Xue Za Zhi., 41, pp. 145-151; Frat, J.P., Thille, A.W., Mercat, A., High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure (2015) N Engl J Med, 372, pp. 2185-2196. , COI: 1:CAS:528:DC%2BC2MXhtFyrsbbL; Branson, R.D., Hess, D.R., Chatbum, R.L., (1995) Respiratory care equipment, pp. 55-62. , J.B. 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Intensive Care,Article,Final,Open Access,Scopus,2-s2.0-85082536012,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Cao Y., Li L., Feng Z., Wan S., Huang P., Sun X., Wen F., Huang X., Ning G., Wang W.",55470284500;57214333935;57215039721;57215035346;53979722200;57215054946;57215041939;57215052707;57215571127;57206572992;,Comparative genetic analysis of the novel coronavirus (2019-nCoV/SARS-CoV-2) receptor ACE2 in different populations,2020,Cell Discovery,6,1,11,,,,2,10.1038/s41421-020-0147-1,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85079784315&doi=10.1038%2fs41421-020-0147-1&partnerID=40&md5=e102b20e9b1029d90f49ff23601c28c0,"National Clinical Research Centre for Metabolic Diseases, State Key Laboratory of Medical Genomics, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China","Cao, Y., National Clinical Research Centre for Metabolic Diseases, State Key Laboratory of Medical Genomics, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China; Li, L., National Clinical Research Centre for Metabolic Diseases, State Key Laboratory of Medical Genomics, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China; Feng, Z., National Clinical Research Centre for Metabolic Diseases, State Key Laboratory of Medical Genomics, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China; Wan, S., National Clinical Research Centre for Metabolic Diseases, State Key Laboratory of Medical Genomics, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China; Huang, P., National Clinical Research Centre for Metabolic Diseases, State Key Laboratory of Medical Genomics, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China; Sun, X., National Clinical Research Centre for Metabolic Diseases, State Key Laboratory of Medical Genomics, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China; Wen, F., National Clinical Research Centre for Metabolic Diseases, State Key Laboratory of Medical Genomics, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China; Huang, X., National Clinical Research Centre for Metabolic Diseases, State Key Laboratory of Medical Genomics, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China; Ning, G., National Clinical Research Centre for Metabolic Diseases, State Key Laboratory of Medical Genomics, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China; Wang, W., National Clinical Research Centre for Metabolic Diseases, State Key Laboratory of Medical Genomics, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China",[No abstract available],,angiotensin converting enzyme 2; lysine; tyrosine; vitronectin; 2019 novel coronavirus; amino acid sequence; Asian; comparative gene mapping; Coronavirinae; Coronavirus infection; East Asian; expression quantitative trait locus; gene expression level; gene frequency; genetic analysis; genetic susceptibility; genetic variability; human; in vitro study; Letter; male; mutation rate; priority journal; RNA sequencing; SARS coronavirus,"Zhou, P., A pneumonia outbreak associated with a new coronavirus of probable bat origin (2020) Nature, , https://doi.org/10.1038/s41586-020-2012-7; Lu, R., Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding (2020) Lancet, pp. 30251-30258. , https://doi.org/10.1016/S0140-6736(20; 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Med., , https://doi.org/10.1056/NEJMc2001468; The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans (2015) Science, 348, pp. 648-660; Auton, A., A global reference for human genetic variation (2015) Nature, 526, pp. 68-74; Taliun, D., (2019) Sequencing of 53,831 Diverse Genomes from the NHLBI Topmed Program, , https://doi.org/10.1101/563866; Cai, G., (2020) Tobacco-Use Disparity in Gene Expression of ACE2, the Receptor of 2019-Ncov, , https://doi.org/10.20944/preprints202002.0051.v1; Imai, Y., Angiotensin-converting enzyme 2 protects from severe acute lung failure (2005) Nature, 436, pp. 112-116","Cao, Y.; National Clinical Research Centre for Metabolic Diseases, State Key Laboratory of Medical Genomics, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of MedicineChina; email: caoyanan@vip.sina.com",,Springer Nature,20565968,,,,English,Cell Discov.,Letter,Final,Open Access,Scopus,2-s2.0-85079784315,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Xu B., Gutierrez B., Mekaru S., Sewalk K., Goodwin L., Loskill A., Cohn E.L., Hswen Y., Hill S.C., Cobo M.M., Zarebski A.E., Li S., Wu C.-H., Hulland E., Morgan J.D., Wang L., O’Brien K., Scarpino S.V., Brownstein J.S., Pybus O.G., Pigott D.M., Kraemer M.U.G.",57215904551;57215091466;35849129900;57203850448;57215924567;57215902608;56675526300;56362606900;56729786400;56979021200;57160212700;57215905980;57215923533;57215924040;57212347646;57215901791;57216038553;36440402600;8872411400;6701390795;55320335600;56308225600;,"Epidemiological data from the COVID-19 outbreak, real-time case information",2020,Scientific Data,7,1,106,,,,,10.1038/s41597-020-0448-0,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082380230&doi=10.1038%2fs41597-020-0448-0&partnerID=40&md5=78f9838a5a3346355a11d447e3bffac5,"Ministry of Education Key Laboratory for Earth System Modeling, Department of Earth System Science, Tsinghua University, Beijing, China; Department of Zoology, University of Oxford, Oxford, United Kingdom; Computational Epidemiology Lab, Boston Children’s Hospital, Boston, United States; Booz Allen Hamilton, Westborough Massachusetts, United States; Mathematical Sciences, University of Southampton, Southampton, United Kingdom; Department of Health Metrics Sciences, University of Washington, Seattle, United States; Mathematical Modelling of Infectious Diseases Unit, Institut Pasteur, UMR2000, CNRS, Paris, France; Network Science Institute, Northeastern University, Boston, United States; Department of Pediatrics, Harvard Medical School, Boston, United States; School of Biological and Environmental Sciences, Universidad San Francisco de Quito USFQ, Quito, Ecuador; School of Public Health, Boston University, Boston, United States; Department of Paediatrics, University of Oxford, Oxford, United Kingdom; School of Geography and the Environment, University of Oxford, Oxford, United Kingdom; Institute for Health Metrics and Evaluation, University of Washington, Seattle, United States; Department of Genetics, University of Cambridge, Cambridge, United Kingdom","Xu, B., Ministry of Education Key Laboratory for Earth System Modeling, Department of Earth System Science, Tsinghua University, Beijing, China, Department of Zoology, University of Oxford, Oxford, United Kingdom; Gutierrez, B., Department of Zoology, University of Oxford, Oxford, United Kingdom, School of Biological and Environmental Sciences, Universidad San Francisco de Quito USFQ, Quito, Ecuador; Mekaru, S., Computational Epidemiology Lab, Boston Children’s Hospital, Boston, United States, Booz Allen Hamilton, Westborough Massachusetts, United States; Sewalk, K., Computational Epidemiology Lab, Boston Children’s Hospital, Boston, United States; Goodwin, L., Computational Epidemiology Lab, Boston Children’s Hospital, Boston, United States; Loskill, A., Computational Epidemiology Lab, Boston Children’s Hospital, Boston, United States, School of Public Health, Boston University, Boston, United States; Cohn, E.L., Computational Epidemiology Lab, Boston Children’s Hospital, Boston, United States; Hswen, Y., Computational Epidemiology Lab, Boston Children’s Hospital, Boston, United States; Hill, S.C., Department of Zoology, University of Oxford, Oxford, United Kingdom; Cobo, M.M., School of Biological and Environmental Sciences, Universidad San Francisco de Quito USFQ, Quito, Ecuador, Department of Paediatrics, University of Oxford, Oxford, United Kingdom; Zarebski, A.E., Department of Zoology, University of Oxford, Oxford, United Kingdom; Li, S., Department of Zoology, University of Oxford, Oxford, United Kingdom, School of Geography and the Environment, University of Oxford, Oxford, United Kingdom; Wu, C.-H., Mathematical Sciences, University of Southampton, Southampton, United Kingdom; Hulland, E., Department of Health Metrics Sciences, University of Washington, Seattle, United States, Institute for Health Metrics and Evaluation, University of Washington, Seattle, United States; Morgan, J.D., Department of Health Metrics Sciences, University of Washington, Seattle, United States, Institute for Health Metrics and Evaluation, University of Washington, Seattle, United States; Wang, L., Mathematical Modelling of Infectious Diseases Unit, Institut Pasteur, UMR2000, CNRS, Paris, France, Department of Genetics, University of Cambridge, Cambridge, United Kingdom; O’Brien, K., Computational Epidemiology Lab, Boston Children’s Hospital, Boston, United States; Scarpino, S.V., Network Science Institute, Northeastern University, Boston, United States; Brownstein, J.S., Computational Epidemiology Lab, Boston Children’s Hospital, Boston, United States, Department of Pediatrics, Harvard Medical School, Boston, United States; Pybus, O.G., Department of Zoology, University of Oxford, Oxford, United Kingdom; Pigott, D.M., Department of Health Metrics Sciences, University of Washington, Seattle, United States, Institute for Health Metrics and Evaluation, University of Washington, Seattle, United States; Kraemer, M.U.G., Department of Zoology, University of Oxford, Oxford, United Kingdom, Computational Epidemiology Lab, Boston Children’s Hospital, Boston, United States, Department of Pediatrics, Harvard Medical School, Boston, United States","Cases of a novel coronavirus were first reported in Wuhan, Hubei province, China, in December 2019 and have since spread across the world. Epidemiological studies have indicated human-to-human transmission in China and elsewhere. To aid the analysis and tracking of the COVID-19 epidemic we collected and curated individual-level data from national, provincial, and municipal health reports, as well as additional information from online reports. All data are geo-coded and, where available, include symptoms, key dates (date of onset, admission, and confirmation), and travel history. The generation of detailed, real-time, and robust data for emerging disease outbreaks is important and can help to generate robust evidence that will support and inform public health decision making. © 2020, The Author(s).",,,"Li, Q., Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia (2020) N. Engl. J. Med. Nejmoa, , https://doi.org/10.1056/NEJMoa2001316; Bogoch, I.I., Pneumonia of Unknown Etiology in Wuhan, China: Potential for International Spread Via Commercial Air Travel (2020) J. 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Dis., 3099, pp. 19-20; Chen, N., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 6736, pp. 1-7; Weinberger, K., Dasgupta, A., Attenberg, J., Langford, J., Smola, A., Feature Hashing for Large Scale Multitask Learning (2009) Proc. 26Th Int. Conf. Mach. Learn. ICML, 2009, pp. 1113-1120; (2019) R: A Language and Environment for Computing. (R Foundation for Statistical, , Computing; Fraser, C., Pandemic potential of a strain of influenza A (H1N1): Early findings (2009) Science, 324, pp. 1557-1562. , COI: 1:CAS:528:DC%2BD1MXnsFOrsrk%3D; Sun, K., Chen, J., Viboud, C., Early epidemiological analysis of the coronavirus disease 2019 outbreak based on crowdsourced data: A population-level observational study. Lancet Digit (2020) Heal, p. 7500; Kraemer, M.U.G., The global compendium of Aedes aegypti and Ae. albopictus occurrence (2015) Sci. Data, 2; Moss, R., Zarebski, A., Dawson, P., McCaw, J.M., Retrospective forecasting of the 2010–2014 Melbourne influenza seasons using multiple surveillance systems (2017) Epidemiol. Infect., 145, pp. 156-169. , COI: 1:STN:280:DC%2BC2svktVWjsw%3D%3D; McGowan, C.J., Collaborative efforts to forecast seasonal influenza in the United States, 2015–2016 (2019) Sci. Rep., 9; Brooks, L.C., Farrow, D.C., Hyun, S., Tibshirani, R.J., Rosenfeld, R., Nonmechanistic forecasts of seasonal influenza with iterative one-week-ahead distributions (2018) PLOS Comput. Biol., 14","Zarebski, A.E.; Department of Zoology, University of OxfordUnited Kingdom; email: alexander.zarebski@zoo.ox.ac.uk",,Nature Research,20524463,,,32210236,English,Sci. Data,Data Paper,Final,Open Access,Scopus,2-s2.0-85082380230,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Sheahan T.P., Sims A.C., Leist S.R., Schäfer A., Won J., Brown A.J., Montgomery S.A., Hogg A., Babusis D., Clarke M.O., Spahn J.E., Bauer L., Sellers S., Porter D., Feng J.Y., Cihlar T., Jordan R., Denison M.R., Baric R.S.",15756255200;7102763252;55846755300;8599352200;57209418741;57209410894;14048667200;57213199601;6508209817;8755030900;57194681768;57213190263;56573731200;55965803400;7403883758;6701481609;8948148800;7101971810;57205312930;,"Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV",2020,Nature Communications,11,1,222,,,,26,10.1038/s41467-019-13940-6,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85077715855&doi=10.1038%2fs41467-019-13940-6&partnerID=40&md5=3b3d409763b2f5344bcf0bb9a55172c2,"Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Department of Pathology & Laboratory Medicine, University of North Carolina, Chapel Hill, NC, United States; Gilead Sciences, Inc, Foster City, CA, United States; Department of Pediatrics-Infectious Diseases, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States","Sheahan, T.P., Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Sims, A.C., Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Leist, S.R., Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Schäfer, A., Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Won, J., Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Brown, A.J., Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; Montgomery, S.A., Department of Pathology & Laboratory Medicine, University of North Carolina, Chapel Hill, NC, United States; Hogg, A., Gilead Sciences, Inc, Foster City, CA, United States; Babusis, D., Gilead Sciences, Inc, Foster City, CA, United States; Clarke, M.O., Gilead Sciences, Inc, Foster City, CA, United States; Spahn, J.E., Gilead Sciences, Inc, Foster City, CA, United States; Bauer, L., Gilead Sciences, Inc, Foster City, CA, United States; Sellers, S., Gilead Sciences, Inc, Foster City, CA, United States; Porter, D., Gilead Sciences, Inc, Foster City, CA, United States; Feng, J.Y., Gilead Sciences, Inc, Foster City, CA, United States; Cihlar, T., Gilead Sciences, Inc, Foster City, CA, United States; Jordan, R., Gilead Sciences, Inc, Foster City, CA, United States; Denison, M.R., Department of Pediatrics-Infectious Diseases, Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States; Baric, R.S., Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States","Middle East respiratory syndrome coronavirus (MERS-CoV) is the causative agent of a severe respiratory disease associated with more than 2468 human infections and over 851 deaths in 27 countries since 2012. There are no approved treatments for MERS-CoV infection although a combination of lopinavir, ritonavir and interferon beta (LPV/RTV-IFNb) is currently being evaluated in humans in the Kingdom of Saudi Arabia. Here, we show that remdesivir (RDV) and IFNb have superior antiviral activity to LPV and RTV in vitro. In mice, both prophylactic and therapeutic RDV improve pulmonary function and reduce lung viral loads and severe lung pathology. In contrast, prophylactic LPV/RTV-IFNb slightly reduces viral loads without impacting other disease parameters. Therapeutic LPV/RTV-IFNb improves pulmonary function but does not reduce virus replication or severe lung pathology. Thus, we provide in vivo evidence of the potential for RDV to treat MERS-CoV infections. © 2020, The Author(s).",,beta interferon; caspase 3; dipeptidyl peptidase IV; lopinavir plus ritonavir; prodrug; remdesivir; antimicrobial activity; comparative study; infectivity; pathology; respiratory disease; virus; acute lung injury; airway resistance; American Thoracic Society Lung Injury Score; animal experiment; animal model; animal tissue; antiviral activity; apoptosis; Article; body plethysmography; bronchoconstriction; Calu-3 cell line; controlled study; cytotoxicity; debridement; EC50; enzyme linked immunosorbent assay; female; flow cytometry; gas exchange; gene expression; histopathology; human; human cell; immunohistochemistry; lung function; lung injury; male; maximum plasma concentration; Middle East respiratory syndrome; Middle East respiratory syndrome coronavirus; mortality; mouse; nonhuman; peak expiratory flow; prophylaxis; protein expression; scoring system; therapeutic equivalent dose; virus load; virus replication; Saudi Arabia; Coronavirus; Mus,"de Wit, E., van Doremalen, N., Falzarano, D., Munster, V.J., SARS and MERS: recent insights into emerging coronaviruses (2016) Nat. 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Pharm., 7, pp. 27-31. , PID: 27057123; Livak, K.J., Schmittgen, T.D., Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method (2001) Methods, 25, pp. 402-408. , COI: 1:CAS:528:DC%2BD38XhtFelt7s%3D","Sheahan, T.P.; Department of Epidemiology, University of North Carolina at Chapel HillUnited States; email: sheahan@email.unc.edu",,Nature Research,20411723,,,31924756,English,Nat. Commun.,Article,Final,Open Access,Scopus,2-s2.0-85077715855,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Su L., Ma X., Yu H., Zhang Z., Bian P., Han Y., Sun J., Liu Y., Yang C., Geng J., Zhang Z., Gai Z.",57215900468;57199215760;21744144300;57215924539;57215924234;55376411900;57216115446;57215924023;57215923632;57215923469;57215901352;35285591400;,The different clinical characteristics of corona virus disease cases between children and their families in China - the character of children with COVID-19,2020,Emerging microbes & infections,9,1,,707,713,,,10.1080/22221751.2020.1744483,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85082380653&doi=10.1080%2f22221751.2020.1744483&partnerID=40&md5=c328c8a8728d3de949ef06af422a66ac,"Department of infectious diseases, Jinan Infectious diseases Hospital of Shandong University, Jinan, China; Department of Respiratory, Qilu Children's Hospital of Shandong University, Jinan, China; Jinan Institute of Pediatrics, Qilu Children's Hospital of Shandong University, Jinan, China","Su, L., Department of infectious diseases, Jinan Infectious diseases Hospital of Shandong University, Jinan, China; Ma, X., Department of Respiratory, Qilu Children's Hospital of Shandong University, Jinan, China; Yu, H., Department of Respiratory, Qilu Children's Hospital of Shandong University, Jinan, China; Zhang, Z., Department of infectious diseases, Jinan Infectious diseases Hospital of Shandong University, Jinan, China; Bian, P., Department of infectious diseases, Jinan Infectious diseases Hospital of Shandong University, Jinan, China; Han, Y., Department of Respiratory, Qilu Children's Hospital of Shandong University, Jinan, China; Sun, J., Department of Respiratory, Qilu Children's Hospital of Shandong University, Jinan, China; Liu, Y., Department of Respiratory, Qilu Children's Hospital of Shandong University, Jinan, China; Yang, C., Department of Respiratory, Qilu Children's Hospital of Shandong University, Jinan, China; Geng, J., Department of infectious diseases, Jinan Infectious diseases Hospital of Shandong University, Jinan, China; Zhang, Z., Department of infectious diseases, Jinan Infectious diseases Hospital of Shandong University, Jinan, China; Gai, Z., Department of Respiratory, Qilu Children's Hospital of Shandong University, Jinan, China, Jinan Institute of Pediatrics, Qilu Children's Hospital of Shandong University, Jinan, China","This study aims to analyze the different clinical characteristics between children and their families infected with severe acute respiratory syndrome coronavirus 2. Clinical data from nine children and their 14 families were collected, including general status, clinical, laboratory test, and imaging characteristics. All the children were detected positive result after their families onset. Three children had fever (22.2%) or cough (11.2%) symptoms and six (66.7%) children had no symptom. Among the 14 adult patients, the major symptoms included fever (57.1%), cough (35.7%), chest tightness/pain (21.4%), fatigue (21.4%) and sore throat (7.1%). Nearly 70% of the patients had normal (71.4%) or decreased (28.6%) white blood cell counts, and 50% (7/14) had lymphocytopenia. There were 10 adults (71.4%) showed abnormal imaging. The main manifestations were pulmonary consolidation (70%), nodular shadow (50%), and ground glass opacity (50%). Five discharged children were admitted again because their stool showed positive result in SARS-CoV-2 PCR. COVID-19 in children is mainly caused by family transmission, and their symptoms are mild and prognosis is better than adult. However, their PCR result in stool showed longer time than their families. Because of the mild or asymptomatic clinical process, it is difficult to recognize early for pediatrician and public health staff.",children; clinical characteristics; corona virus diseases-19 (COVID-19); Coronavirus; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),,,,,NLM (Medline),22221751,,,32208917,English,Emerg Microbes Infect,Article,Final,Open Access,Scopus,2-s2.0-85082380653,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Peng X., Xu X., Li Y., Cheng L., Zhou X., Ren B.",57215523157;55619297408;57215524470;57214507824;56340768800;35225254100;,Transmission routes of 2019-nCoV and controls in dental practice,2020,International Journal of Oral Science,12,1,9,,,,2,10.1038/s41368-020-0075-9,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081042657&doi=10.1038%2fs41368-020-0075-9&partnerID=40&md5=b4810b6b59dc136e167aed4b4dd2d531,"State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China","Peng, X., State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China; Xu, X., State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China; Li, Y., State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China; Cheng, L., State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China; Zhou, X., State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China; Ren, B., State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China","A novel β-coronavirus (2019-nCoV) caused severe and even fetal pneumonia explored in a seafood market of Wuhan city, Hubei province, China, and rapidly spread to other provinces of China and other countries. The 2019-nCoV was different from SARS-CoV, but shared the same host receptor the human angiotensin-converting enzyme 2 (ACE2). The natural host of 2019-nCoV may be the bat Rhinolophus affinis as 2019-nCoV showed 96.2% of whole-genome identity to BatCoV RaTG13. The person-to-person transmission routes of 2019-nCoV included direct transmission, such as cough, sneeze, droplet inhalation transmission, and contact transmission, such as the contact with oral, nasal, and eye mucous membranes. 2019-nCoV can also be transmitted through the saliva, and the fetal–oral routes may also be a potential person-to-person transmission route. The participants in dental practice expose to tremendous risk of 2019-nCoV infection due to the face-to-face communication and the exposure to saliva, blood, and other body fluids, and the handling of sharp instruments. Dental professionals play great roles in preventing the transmission of 2019-nCoV. Here we recommend the infection control measures during dental practice to block the person-to-person transmission routes in dental clinics and hospitals. © 2020, The Author(s).",,"COVID-19; severe acute respiratory syndrome coronavirus 2; Betacoronavirus; China; Coronavirus infection; dental clinic; dental procedure; dentist; disease transmission; epidemic; health care personnel; human; infection control; pathogenicity; procedures; virus pneumonia; Betacoronavirus; China; Coronavirus Infections; Dental Care; Dental Clinics; Dentists; Disease Outbreaks; Health Personnel; Humans; Infection Control; Infectious Disease Transmission, Patient-to-Professional; Pneumonia, Viral","Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., Zhao, X., Tan, W., A Novel Coronavirus from Patients with Pneumonia in China, 2019 (2020) New England Journal of Medicine, 382 (8), pp. 727-733; Wang, C., Horby, P.W., Hayden, F.G., Gao, G.F., A novel coronavirus outbreak of global health concern (2020) Lancet, 395, pp. 470-473; Liu, T., Transmission dynamics of 2019 novel coronavirus (2019-nCoV) (2020) The Lancet, , https://ssrn.com/abstract=3526307; Huang, C., Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506; Guan, W.-J., (2020) Clinical Characteristics of 2019 Novel Coronavirus Infection in China, , https://www.medrxiv.org/content/10.1101/2020.02.06.20020974v1, Preprint at; Wang, D., Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan (2020) JAMA, , https://doi.org/10.1001/jama.2020.1585, China; Chen, N., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study (2020) Lancet, 395, pp. 507-513; Chan, J.F.-W., A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster (2020) Lancet, 395, pp. 514-523; Li, Q., Early transmission dynamics in Wuhan, China, of novel coronavirus–infected pneumonia (2020) N. 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Epidemiol., 28, pp. 80-82; Wrapp, D., Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation (2020) Science, 2507. , https://doi.org/10.1126/science.abb2507, eabb; The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China (2020) Chinese Journal of Epidemiology, 41, pp. 145-151","Zhou, X.; State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan UniversityChina; email: zhouxd@scu.edu.cn",,Springer Nature,16742818,,,32127517,English,Int. J. Oral Sci.,Review,Final,Open Access,Scopus,2-s2.0-85081042657,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,, "Borenstein R., Hanson B.A., Markosyan R.M., Gallo E.S., Narasipura S.D., Bhutta M., Shechter O., Lurain N.S., Cohen F.S., Al-Harthi L., Nicholson D.A.",57202582752;57198238795;6604074194;57215828232;8944684400;57215836175;57215834653;6701749578;7202942007;7004503402;7202385662;,Ginkgolic acid inhibits fusion of enveloped viruses,2020,Scientific Reports,10,1,4746,,,,,10.1038/s41598-020-61700-0,https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081991492&doi=10.1038%2fs41598-020-61700-0&partnerID=40&md5=09302de7baa79f846a4805bb2660d082,"Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, United States; Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA, United States; Department of Physiology and Biophysics, Rush University Medical Center, Chicago, IL, United States; Independent researcher, Chicago, IL, United States; Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, IL, United States","Borenstein, R., Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, United States, Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA, United States; Hanson, B.A., Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, United States; Markosyan, R.M., Department of Physiology and Biophysics, Rush University Medical Center, Chicago, IL, United States; Gallo, E.S., Independent researcher, Chicago, IL, United States; Narasipura, S.D., Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, IL, United States; Bhutta, M., Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA, United States; Shechter, O., Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA, United States; Lurain, N.S., Independent researcher, Chicago, IL, United States; Cohen, F.S., Department of Physiology and Biophysics, Rush University Medical Center, Chicago, IL, United States; Al-Harthi, L., Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, IL, United States; Nicholson, D.A., Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, United States","Ginkgolic acids (GA) are alkylphenol constituents of the leaves and fruits of Ginkgo biloba. GA has shown pleiotropic effects in vitro, including: antitumor effects through inhibition of lipogenesis; decreased expression of invasion associated proteins through AMPK activation; and potential rescue of amyloid-β (Aβ) induced synaptic impairment. GA was also reported to have activity against Escherichia coli and Staphylococcus aureus. Several mechanisms for this activity have been suggested including: SUMOylation inhibition; blocking formation of the E1-SUMO intermediate; inhibition of fatty acid synthase; non-specific SIRT inhibition; and activation of protein phosphatase type-2C. Here we report that GA inhibits Herpes simplex virus type 1 (HSV-1) by inhibition of both fusion and viral protein synthesis. Additionally, we report that GA inhibits human cytomegalovirus (HCMV) genome replication and Zika virus (ZIKV) infection of normal human astrocytes (NHA). We show a broad spectrum of fusion inhibition by GA of all three classes of fusion proteins including HIV, Ebola virus (EBOV), influenza A virus (IAV) and Epstein Barr virus (EBV). In addition, we show inhibition of a non-enveloped adenovirus. Our experiments suggest that GA inhibits virion entry by blocking the initial fusion event. Data showing inhibition of HSV-1 and CMV replication, when GA is administered post-infection, suggest a possible secondary mechanism targeting protein and DNA synthesis. Thus, in light of the strong effect of GA on viral infection, even after the infection begins, it may potentially be used to treat acute infections (e.g. Coronavirus, EBOV, ZIKV, IAV and measles), and also topically for the successful treatment of active lesions (e.g. HSV-1, HSV-2 and varicella-zoster virus (VZV)). © 2020, The Author(s).",,,"Isah, T., Rethinking Ginkgo biloba L.: Medicinal uses and conservation (2015) Pharmacogn. Rev., 9, pp. 140-148; van Beek, T.A., Montoro, P., Chemical analysis and quality control of Ginkgo biloba leaves, extracts, and phytopharmaceuticals (2009) J. Chromatogr. A, 1216, pp. 2002-2032; He, X., Bernart, M.W., Nolan, G.S., Lin, L., Lindenmaier, M.P., High-performance liquid chromatography-electrospray ionization-mass spectrometry study of ginkgolic acid in the leaves and fruits of the ginkgo tree (Ginkgo biloba) (2000) J. Chromatogr. Sci., 38, pp. 169-173; Ma, J., Ginkgolic acid suppresses the development of pancreatic cancer by inhibiting pathways driving lipogenesis (2015) Oncotarget, 6, pp. 20993-21003; Qiao, L., Ginkgolic acid inhibits the invasiveness of colon cancer cells through AMPK activation (2017) Oncol. Lett., 14, pp. 5831-5838; Mango, D., Weisz, F., Nistico, R., Ginkgolic Acid Protects against Abeta-Induced Synaptic Dysfunction in the Hippocampus (2016) Front. 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Virol., 73, pp. 4110-4119. , COI: 1:CAS:528:DyaK1MXis1entL4%3D, PID: 10196307; Lurain, N.S., The Association of Human Cytomegalovirus with Biomarkers of Inflammation and Immune Activation in HIV-1-Infected Women (2016) AIDS Res. Hum. Retroviruses, 32, pp. 134-143; Melikyan, G.B., Markosyan, R.M., Brener, S.A., Rozenberg, Y., Cohen, F.S., Role of the cytoplasmic tail of ecotropic moloney murine leukemia virus Env protein in fusion pore formation (2000) J. Virol., 74, pp. 447-455; Markosyan, R.M., Induction of Cell-Cell Fusion by Ebola Virus Glycoprotein: Low pH Is Not a Trigger (2016) PLoS Pathog., 12; Melikyan, G.B., Evidence that the transition of HIV-1 gp41 into a six-helix bundle, not the bundle configuration, induces membrane fusion (2000) J. Cell Biol., 151, pp. 413-423; Markosyan, R.M., Kielian, M., Cohen, F.S., Fusion induced by a class II viral fusion protein, semliki forest virus E1, is dependent on the voltage of the target cell (2007) J. Virol., 81, pp. 11218-11225; Markosyan, R.M., Cohen, F.S., The transmembrane domain and acidic lipid flip-flop regulates voltage-dependent fusion mediated by class II and III viral proteins (2013) PLoS One, 8","Borenstein, R.; Department of Neurological Sciences, Rush University Medical CenterUnited States; email: BorensR@evms.edu",,Nature Research,20452322,,,32179788,English,Sci. Rep.,Article,Final,Open Access,Scopus,2-s2.0-85081991492,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,