ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count hsa04142 Lysosome 29/179 123/7916 3.95224996904863e-22 1.03944174185979e-19 8.57014203814757e-20 537/1522/5476/51606/410/2717/3074/245972/1075/533/3373/967/411/2760/2799/2720/7805/5660/1509/1200/10312/1513/79158/10577/968/527/9114/54/4668 29 hsa05323 Rheumatoid arthritis 20/179 93/7916 1.07129711911896e-14 1.40875571164144e-12 1.16151161336056e-12 537/529/51606/9296/8992/526/6374/245972/533/8600/1435/523/9550/10312/1513/527/9114/8792/3383/54 20 hsa05120 Epithelial cell signaling in Helicobacter pylori infection 16/179 70/7916 2.04263212197683e-12 1.79070749359968e-10 1.47642883202535e-10 537/529/6714/51606/9296/8992/5603/526/245972/533/50848/523/9550/10312/527/9114 16 hsa04966 Collecting duct acid secretion 11/179 27/7916 5.53648600167456e-12 3.64023954610102e-10 3.00135820090779e-10 529/9296/8992/526/245972/523/9550/10312/760/527/9114 11 hsa05110 Vibrio cholerae infection 13/179 50/7916 4.47156578770052e-11 2.35204360433047e-09 1.93924747845538e-09 537/529/51606/9296/8992/526/245972/533/523/9550/10312/527/9114 13 hsa04145 Phagosome 19/179 152/7916 1.10821922610463e-09 4.8576942744253e-08 4.00514316802726e-08 537/529/51606/9296/51807/8992/526/245972/533/523/9550/10312/84790/527/9114/1535/83547/3690/9902 19 hsa04380 Osteoclast differentiation 16/179 128/7916 2.45500825920125e-08 9.22381674528468e-07 7.60498799090913e-07 126014/5603/8600/1435/4772/5291/79168/11006/1513/1535/1436/8792/3690/7305/6688/54 16 hsa04721 Synaptic vesicle cycle 12/179 78/7916 1.46393899822165e-07 4.81269945665366e-06 3.96804517939025e-06 529/51606/9296/8992/526/245972/533/523/9550/10312/527/9114 12 hsa04670 Leukocyte transendothelial migration 14/179 112/7916 1.91177668067092e-07 5.58663630018281e-06 4.60615200255217e-06 4318/10398/2771/5603/7408/50848/2185/5291/103910/5880/137075/1535/1366/3383 14 hsa00190 Oxidative phosphorylation 14/179 133/7916 1.60959123737625e-06 4.23322495429954e-05 3.49027152525798e-05 537/529/51606/9296/8992/526/245972/533/523/9550/64077/10312/527/9114 14 hsa05152 Tuberculosis 15/179 179/7916 1.17586387570857e-05 0.000281138363010322 0.00023179708937413 537/6714/51606/5603/808/245972/2207/533/8717/1509/10312/7421/527/9114/9902 15 hsa04611 Platelet activation 12/179 124/7916 2.17247067410381e-05 0.000476133156074417 0.000392569262162618 6714/2771/5603/2207/7408/8673/5291/103910/83706/54518/5330/3690 12 hsa00531 Glycosaminoglycan degradation 5/179 19/7916 5.02535313609964e-05 0.00101666759599554 0.000838237041325123 3074/3373/411/2799/2720 5 hsa04015 Rap1 signaling pathway 15/179 210/7916 7.67184963331502e-05 0.00144121175254418 0.00118827144696458 6714/2771/6237/5603/808/7408/1435/5291/54518/5880/5330/27040/5216/1436/3690 15 hsa05165 Human papillomavirus infection 19/179 330/7916 0.000158478729887651 0.00277866039736347 0.00229099076188463 537/529/51606/9296/7482/1026/8992/526/245972/7473/533/8717/5291/523/9550/10312/527/9114/3690 19 hsa00603 Glycosphingolipid biosynthesis - globo and isoglobo series 4/179 15/7916 0.000283917001225115 0.00466688570763783 0.00384782251660354 2717/3074/26301/4668 4 hsa04150 mTOR signaling pathway 11/179 153/7916 0.000669819247214715 0.0103624977657335 0.00854382445363661 529/51606/9296/7482/526/6196/7473/5291/55437/523/9550 11 hsa04668 TNF signaling pathway 9/179 112/7916 0.000940098385329888 0.0137358819634311 0.0113251618349682 4318/5603/6374/330/8717/1435/5291/197259/3383 9 hsa05418 Fluid shear stress and atherosclerosis 10/179 139/7916 0.00116721976341148 0.01615677883038 0.0133211784633111 4318/6714/5603/808/2948/5291/5880/1535/3690/3383 10 hsa05163 Human cytomegalovirus infection 13/179 225/7916 0.00172033480997287 0.0226224027511432 0.0186520510976005 6714/2771/1026/5603/808/8717/2185/4772/5291/1230/5880/5330/3690 13 hsa04625 C-type lectin receptor signaling pathway 8/179 104/7916 0.0023737505681252 0.0293114715473659 0.0241671528467376 6714/6237/5603/808/2207/868/4772/5291 8 hsa04662 B cell receptor signaling pathway 7/179 82/7916 0.00245191016746027 0.0293114715473659 0.0241671528467376 4772/5291/79168/11006/971/5880/118788 7 hsa04210 Apoptosis 9/179 136/7916 0.00360820129389248 0.0412589974040748 0.0340178245556911 1522/51807/1075/330/8717/5291/1509/1513/84790 9 hsa00052 Galactose metabolism 4/179 31/7916 0.00493625330059649 0.0540931090857032 0.0445994815755648 2717/2582/3098/2720 4 hsa04071 Sphingolipid signaling pathway 8/179 119/7916 0.00543204026049582 0.057145063540416 0.0471158018384059 2771/5603/2207/8717/5291/1509/5880/5330 8 hsa05135 Yersinia infection 8/179 120/7916 0.00571051261969311 0.0577640314992034 0.0476261376379264 6714/5603/6196/2185/4772/5291/5880/27040 8 hsa04514 Cell adhesion molecules (CAMs) 9/179 147/7916 0.00600663800338779 0.0585091035144811 0.0482404455632704 50848/965/920/6404/80381/137075/1013/1366/3383 9 hsa04971 Gastric acid secretion 6/179 75/7916 0.00681328061109673 0.06399617145423 0.0527645039806739 2771/808/6522/3274/760/5330 6 hsa00511 Other glycan degradation 3/179 18/7916 0.00722454595247838 0.0655191581207522 0.0540201984105462 3074/2519/2720 3 hsa04360 Axon guidance 10/179 181/7916 0.00785496227010835 0.0688618359012832 0.0567762185137656 6714/10398/2771/6237/5291/103910/10507/5880/8482/10501 10 hsa00480 Glutathione metabolism 5/179 56/7916 0.00841245705242469 0.0713702001544418 0.0588443515381829 373156/290/2948/2678/2876 5 hsa04926 Relaxin signaling pathway 8/179 129/7916 0.00873271790221813 0.0717720252588553 0.0591756542058202 4318/6714/2771/5603/2769/408/5291/5330 8 hsa04650 Natural killer cell mediated cytotoxicity 8/179 131/7916 0.0095420920051152 0.0755324958271819 0.0622761422469461 2207/2185/4772/5291/5880/27040/7305/3383 8 hsa00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 3/179 20/7916 0.00976465725522504 0.0755324958271819 0.0622761422469461 56548/166012/9469 3 hsa04530 Tight junction 9/179 169/7916 0.0143061447253253 0.105470947121383 0.0869602365699615 6714/10398/51807/7408/50848/103910/84790/137075/1366 9 hsa04614 Renin-angiotensin system 3/179 23/7916 0.0144370878188965 0.105470947121383 0.0869602365699615 5476/290/7064 3 hsa05130 Pathogenic Escherichia coli infection 10/179 201/7916 0.0156462885729811 0.111215510667406 0.0916965987491924 27128/51807/4643/5603/10095/8717/7009/84790/137075/1366 10 hsa05205 Proteoglycans in cancer 10/179 204/7916 0.0171882692943216 0.117686378301533 0.0970317947973418 4318/6714/7482/1026/6237/5603/7473/967/5291/3690 10 hsa05131 Shigellosis 5/179 67/7916 0.017451592219619 0.117686378301533 0.0970317947973418 6714/5603/10095/391/5216 5 hsa04664 Fc epsilon RI signaling pathway 5/179 68/7916 0.0185020773613996 0.121651158651203 0.100300735169693 5603/2207/5291/5880/27040 5 hsa04917 Prolactin signaling pathway 5/179 70/7916 0.0207263386088112 0.132606729750413 0.109333545441606 6714/5603/8600/5291/8792 5 hsa00600 Sphingolipid metabolism 4/179 47/7916 0.0211767401122333 0.132606729750413 0.109333545441606 410/2717/55331/2720 4 hsa04921 Oxytocin signaling pathway 8/179 153/7916 0.0225144585545686 0.137704711624454 0.113536804461227 6714/10398/2771/1026/808/4772/93589/5330 8 hsa04640 Hematopoietic cell lineage 6/179 98/7916 0.0233398961366253 0.139508924634829 0.115024368520211 290/945/1435/920/1436/3690 6 hsa05167 Kaposi sarcoma-associated herpesvirus infection 9/179 186/7916 0.0250296356030491 0.146284314746709 0.12061064173633 6714/1026/5603/808/8717/4772/5291/1230/3383 9 hsa04062 Chemokine signaling pathway 9/179 189/7916 0.0273937041749897 0.155305087134072 0.128048220730914 6714/2771/6374/408/2185/5291/1230/5880/5330 9 hsa04064 NF-kappa B signaling pathway 6/179 102/7916 0.0277541410467734 0.155305087134072 0.128048220730914 330/8717/8600/27040/8792/3383 6 hsa04660 T cell receptor signaling pathway 6/179 104/7916 0.0301552384511316 0.162902787789009 0.134312484628921 5603/868/4772/5291/920/27040 6 hsa05161 Hepatitis B 8/179 162/7916 0.0303507095120208 0.162902787789009 0.134312484628921 537/4318/6714/1026/5603/2185/4772/5291 8 hsa04928 Parathyroid hormone synthesis, secretion and action 6/179 106/7916 0.03268893060142 0.171943774963469 0.141766730608263 2771/1026/408/8600/7421/5330 6 hsa05132 Salmonella infection 5/179 80/7916 0.0344424567774794 0.177615022205433 0.146442643883607 5603/10095/391/83547/5216 5 hsa04915 Estrogen signaling pathway 7/179 138/7916 0.0367059314445725 0.185647307113895 0.153065220193966 4318/6714/2771/808/5291/1509/5330 7 hsa04370 VEGF signaling pathway 4/179 59/7916 0.0439488702471244 0.214381135572683 0.176756109377517 6714/5603/5291/5880 4 hsa00604 Glycosphingolipid biosynthesis - ganglio series 2/179 15/7916 0.0440174194711972 0.214381135572683 0.176756109377517 3074/2720 2 hsa04540 Gap junction 5/179 88/7916 0.0487033047925666 0.219257963904806 0.180777028474645 6714/2771/51807/84790/5330 5 hsa05224 Breast cancer 7/179 147/7916 0.0488490924401542 0.219257963904806 0.180777028474645 7482/1026/10023/7473/8600/5291/23401 7 hsa01200 Carbon metabolism 6/179 117/7916 0.0490821556086583 0.219257963904806 0.180777028474645 3098/7086/113675/3030/2805/50 6 hsa04072 Phospholipase D signaling pathway 7/179 148/7916 0.0503387829600244 0.219257963904806 0.180777028474645 27128/6237/2207/2185/5291/5330/9162 7 hsa05143 African trypanosomiasis 3/179 37/7916 0.0503951477387257 0.219257963904806 0.180777028474645 7064/5330/3383 3 hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer 5/179 89/7916 0.0506978872608958 0.219257963904806 0.180777028474645 5603/4772/5291/920/27040 5 hsa05170 Human immunodeficiency virus 1 infection 9/179 212/7916 0.0509244052237581 0.219257963904806 0.180777028474645 2771/5603/808/8717/2185/4772/5291/920/5880 9 hsa04810 Regulation of actin cytoskeleton 9/179 213/7916 0.052178825081991 0.219257963904806 0.180777028474645 6714/10398/6237/10095/5291/103910/5880/5216/3690 9 hsa04722 Neurotrophin signaling pathway 6/179 119/7916 0.0525218696806189 0.219257963904806 0.180777028474645 5603/6196/808/5291/5664/4145 6 hsa04024 cAMP signaling pathway 9/179 216/7916 0.0560635511232728 0.230386155397199 0.189952163345299 10398/2771/6237/808/4772/56670/5291/5880/2696 9 hsa04666 Fc gamma R-mediated phagocytosis 5/179 93/7916 0.0591507391284613 0.235706733193717 0.194338951522536 10095/7408/5291/5880/27040 5 hsa04912 GnRH signaling pathway 5/179 93/7916 0.0591507391284613 0.235706733193717 0.194338951522536 6714/5603/808/2185/5330 5 hsa01210 2-Oxocarboxylic acid metabolism 2/179 18/7916 0.061384928673375 0.240958749867129 0.198669211417365 2805/50 2 hsa05219 Bladder cancer 3/179 41/7916 0.0648136309663291 0.250676249178596 0.206681238066003 4318/6714/1026 3 hsa04310 Wnt signaling pathway 7/179 160/7916 0.0704670055299839 0.262192972371442 0.216176715263226 7482/10023/7473/4772/23401/5880/5330 7 hsa04010 MAPK signaling pathway 11/179 295/7916 0.0706653539433882 0.262192972371442 0.216176715263226 1846/6237/5603/6196/8717/408/1435/4772/93589/5880/1436 11 hsa01522 Endocrine resistance 5/179 98/7916 0.0707821332257506 0.262192972371442 0.216176715263226 4318/6714/1026/5603/5291 5 hsa04061 Viral protein interaction with cytokine and cytokine receptor 5/179 100/7916 0.0757635059178269 0.269267595356601 0.222009704396477 6374/1435/8764/1230/1436 5 hsa04750 Inflammatory mediator regulation of TRP channels 5/179 100/7916 0.0757635059178269 0.269267595356601 0.222009704396477 6714/5603/808/5291/5330 5 hsa04933 AGE-RAGE signaling pathway in diabetic complications 5/179 100/7916 0.0757635059178269 0.269267595356601 0.222009704396477 5603/4772/5291/5330/3383 5 hsa04916 Melanogenesis 5/179 101/7916 0.0783239713036049 0.274656059371308 0.226452464400598 2771/7482/808/7473/5330 5 hsa05142 Chagas disease (American trypanosomiasis) 5/179 102/7916 0.0809306635848849 0.275705779225736 0.227317952853719 2771/5603/2769/5291/5330 5 hsa04510 Focal adhesion 8/179 199/7916 0.0816015249579906 0.275705779225736 0.227317952853719 6714/10398/330/7408/5291/103910/5880/3690 8 hsa01524 Platinum drug resistance 4/179 73/7916 0.0828165648624835 0.275705779225736 0.227317952853719 1026/330/2948/5291 4 hsa05100 Bacterial invasion of epithelial cells 4/179 73/7916 0.0828165648624835 0.275705779225736 0.227317952853719 6714/10095/5291/391 4 hsa05225 Hepatocellular carcinoma 7/179 168/7916 0.0862191887446045 0.283445582997887 0.23369938001827 7482/1026/10023/7473/2948/5291/23401 7 hsa01230 Biosynthesis of amino acids 4/179 75/7916 0.0894081335968493 0.287175721704495 0.236774859600264 7086/113675/2805/50 4 hsa04973 Carbohydrate digestion and absorption 3/179 47/7916 0.0895376774896143 0.287175721704495 0.236774859600264 3098/5291/5330 3 hsa05133 Pertussis 4/179 76/7916 0.0927961982921827 0.29404096567282 0.24243521684451 2771/5603/6374/808 4 hsa00520 Amino sugar and nucleotide sugar metabolism 3/179 48/7916 0.0939931414727055 0.294288050087161 0.242638936633801 2582/3074/3098 3 hsa00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 2/179 24/7916 0.101504680303444 0.314067422585949 0.258946924365441 2131/9956 2 hsa05226 Gastric cancer 6/179 149/7916 0.121307810324455 0.370976210643391 0.305867918321147 7482/1026/10023/7473/5291/23401 6 hsa04012 ErbB signaling pathway 4/179 85/7916 0.12590937557415 0.380622595126452 0.313821311170899 6714/1026/868/5291 4 hsa04392 Hippo signaling pathway - multiple species 2/179 29/7916 0.138981250193995 0.415364418193416 0.342465760047403 23286/83937 2 hsa04970 Salivary secretion 4/179 90/7916 0.146181539710798 0.431974662291459 0.356160818219094 1471/808/6522/5330 4 hsa04218 Cellular senescence 6/179 160/7916 0.154157972308314 0.442969176320264 0.365225736729936 1026/6237/5603/808/4772/5291 6 hsa04658 Th1 and Th2 cell differentiation 4/179 92/7916 0.154627788725893 0.442969176320264 0.365225736729936 5603/4772/920/27040 4 hsa04014 Ras signaling pathway 8/179 232/7916 0.154954997039788 0.442969176320264 0.365225736729936 6237/100271927/808/1435/5291/5880/27040/1436 8 hsa04657 IL-17 signaling pathway 4/179 94/7916 0.163253840784042 0.461674840066699 0.380648457289334 4318/5603/6374/8717 4 hsa05217 Basal cell carcinoma 3/179 63/7916 0.170255599982974 0.476353433994917 0.392750880139896 7482/1026/7473 3 hsa04929 GnRH secretion 3/179 64/7916 0.175858547024649 0.48467706676709 0.399613671218814 408/5291/5330 3 hsa04022 cGMP-PKG signaling pathway 6/179 167/7916 0.176916343762892 0.48467706676709 0.399613671218814 10398/2771/808/7408/4772/5330 6 hsa05231 Choline metabolism in cancer 4/179 98/7916 0.181009628760484 0.487988340878124 0.402343799163072 6580/5291/5880/9162 4 hsa04144 Endocytosis 8/179 243/7916 0.184765476957258 0.487988340878124 0.402343799163072 27128/6714/116988/2350/10095/408/868/6456 8 hsa04070 Phosphatidylinositol signaling system 4/179 99/7916 0.18554689767229 0.487988340878124 0.402343799163072 808/5291/5330/9162 4 hsa04914 Progesterone-mediated oocyte maturation 4/179 99/7916 0.18554689767229 0.487988340878124 0.402343799163072 2771/5603/6196/5291 4 hsa04720 Long-term potentiation 3/179 67/7916 0.192964488198721 0.497545690159446 0.41022378296116 6196/808/5330 3 hsa05221 Acute myeloid leukemia 3/179 67/7916 0.192964488198721 0.497545690159446 0.41022378296116 5291/1436/6688 3 hsa04371 Apelin signaling pathway 5/179 137/7916 0.198225787647898 0.506149341275702 0.417317447679786 2771/6237/1490/808/5330 5 hsa00920 Sulfur metabolism 1/179 10/7916 0.204553547804343 0.512455414049112 0.422516771239212 23474 1 hsa04924 Renin secretion 3/179 69/7916 0.204592465685007 0.512455414049112 0.422516771239212 2771/808/5330 3 hsa05340 Primary immunodeficiency 2/179 38/7916 0.211900888285615 0.525754090746383 0.43348145965081 100/920 2 hsa04520 Adherens junction 3/179 71/7916 0.216378061566643 0.528562426520885 0.435796917603772 6714/5880/5795 3 hsa04115 p53 signaling pathway 3/179 72/7916 0.22232430296871 0.528562426520885 0.435796917603772 1026/55240/64065 3 hsa04976 Bile secretion 3/179 72/7916 0.22232430296871 0.528562426520885 0.435796917603772 6580/6522/760 3 hsa00430 Taurine and hypotaurine metabolism 1/179 11/7916 0.222563276484209 0.528562426520885 0.435796917603772 2678 1 hsa04659 Th17 cell differentiation 4/179 107/7916 0.223081480394746 0.528562426520885 0.435796917603772 5603/4772/920/27040 4 hsa04216 Ferroptosis 2/179 40/7916 0.228632185123619 0.536877363281356 0.442652538867158 64116/55240 2 hsa05212 Pancreatic cancer 3/179 75/7916 0.240350265847466 0.554492279981435 0.457175944271266 1026/5291/5880 3 hsa05214 Glioma 3/179 75/7916 0.240350265847466 0.554492279981435 0.457175944271266 1026/808/5291 3 hsa05202 Transcriptional misregulation in cancer 6/179 186/7916 0.244705421904963 0.55963066053048 0.461412511784186 4318/1026/85414/330/1436/6688 6 hsa04261 Adrenergic signaling in cardiomyocytes 5/179 149/7916 0.247603105713466 0.561376006919323 0.462851540625898 2771/5603/808/93589/5330 5 hsa04020 Calcium signaling pathway 6/179 193/7916 0.27143376179419 0.604266125593431 0.498214216018598 808/2769/2185/3274/93129/5330 6 hsa04934 Cushing syndrome 5/179 155/7916 0.273413189907294 0.604266125593431 0.498214216018598 2771/7482/1026/7473/5330 5 hsa05160 Hepatitis C 5/179 155/7916 0.273413189907294 0.604266125593431 0.498214216018598 1026/8717/5291/137075/1366 5 hsa04930 Type II diabetes mellitus 2/179 46/7916 0.279188125107426 0.611887307527108 0.504497840106401 3098/5291 2 hsa04919 Thyroid hormone signaling pathway 4/179 119/7916 0.282538924593866 0.614113530315594 0.506333348989443 6714/5291/5330/3690 4 hsa05169 Epstein-Barr virus infection 6/179 201/7916 0.302805007734684 0.642987680720146 0.530139932873124 1026/5603/8717/965/5291/3383 6 hsa05203 Viral carcinogenesis 6/179 201/7916 0.302805007734684 0.642987680720146 0.530139932873124 6714/1026/245972/8717/5291/9114 6 hsa00270 Cysteine and methionine metabolism 2/179 49/7916 0.304439597639639 0.642987680720146 0.530139932873124 113675/2805 2 hsa00730 Thiamine metabolism 1/179 16/7916 0.306707558169019 0.642987680720146 0.530139932873124 26289 1 hsa05210 Colorectal cancer 3/179 86/7916 0.308047329926762 0.642987680720146 0.530139932873124 1026/5291/5880 3 hsa00330 Arginine and proline metabolism 2/179 50/7916 0.312825793135662 0.647293865969511 0.533690359774742 2805/1152 2 hsa05014 Amyotrophic lateral sclerosis (ALS) 2/179 51/7916 0.321190578957478 0.647293865969511 0.533690359774742 5603/2876 2 hsa00120 Primary bile acid biosynthesis 1/179 17/7916 0.322416336281392 0.647293865969511 0.533690359774742 80270 1 hsa00360 Phenylalanine metabolism 1/179 17/7916 0.322416336281392 0.647293865969511 0.533690359774742 2805 1 hsa00910 Nitrogen metabolism 1/179 17/7916 0.322416336281392 0.647293865969511 0.533690359774742 760 1 hsa04961 Endocrine and other factor-regulated calcium reabsorption 2/179 53/7916 0.337842851893492 0.673126288242337 0.554989054944652 7421/5330 2 hsa04728 Dopaminergic synapse 4/179 131/7916 0.344079481406138 0.676618265075165 0.55786817132473 2771/5603/808/5330 4 hsa05222 Small cell lung cancer 3/179 92/7916 0.34538683776836 0.676618265075165 0.55786817132473 1026/330/5291 3 hsa04060 Cytokine-cytokine receptor interaction 8/179 294/7916 0.34731355811843 0.676618265075165 0.55786817132473 6374/8600/1435/8764/920/1230/1436/8792 8 hsa04923 Regulation of lipolysis in adipocytes 2/179 55/7916 0.354371832841748 0.685292588510146 0.565020104995357 2771/5291 2 hsa04140 Autophagy - animal 4/179 137/7916 0.375077487874541 0.7017398432766 0.578580779327515 6237/8673/5291/1509 4 hsa04910 Insulin signaling pathway 4/179 137/7916 0.375077487874541 0.7017398432766 0.578580779327515 808/3098/868/5291 4 hsa05166 Human T-cell leukemia virus 1 infection 6/179 219/7916 0.375346798000733 0.7017398432766 0.578580779327515 1026/4772/5291/920/6688/3383 6 hsa04713 Circadian entrainment 3/179 97/7916 0.376387353336543 0.7017398432766 0.578580779327515 2771/808/5330 3 hsa05215 Prostate cancer 3/179 97/7916 0.376387353336543 0.7017398432766 0.578580779327515 4318/1026/5291 3 hsa05213 Endometrial cancer 2/179 58/7916 0.378886151122727 0.7017398432766 0.578580779327515 1026/5291 2 hsa00220 Arginine biosynthesis 1/179 21/7916 0.381790005963744 0.702173227751501 0.578938102528754 2805 1 hsa04621 NOD-like receptor signaling pathway 5/179 181/7916 0.389649606767439 0.703358705836976 0.579915522923422 5603/9051/330/5330/1535 5 hsa04550 Signaling pathways regulating pluripotency of stem cells 4/179 140/7916 0.39054580011285 0.703358705836976 0.579915522923422 7482/5603/7473/5291 4 hsa04730 Long-term depression 2/179 60/7916 0.395014517240375 0.703358705836976 0.579915522923422 2771/5330 2 hsa05416 Viral myocarditis 2/179 60/7916 0.395014517240375 0.703358705836976 0.579915522923422 5880/3383 2 hsa00514 Other types of O-glycan biosynthesis 1/179 22/7916 0.395806420014724 0.703358705836976 0.579915522923422 285203 1 hsa00561 Glycerolipid metabolism 2/179 61/7916 0.403007802161531 0.708554496335305 0.584199424635072 2717/9162 2 hsa04972 Pancreatic secretion 3/179 102/7916 0.407091305461717 0.708554496335305 0.584199424635072 6522/760/5330 3 hsa05146 Amoebiasis 3/179 102/7916 0.407091305461717 0.708554496335305 0.584199424635072 2769/5291/5330 3 hsa04964 Proximal tubule bicarbonate reclamation 1/179 23/7916 0.409506781151963 0.708554496335305 0.584199424635072 760 1 hsa00590 Arachidonic acid metabolism 2/179 63/7916 0.418842849238746 0.715999023482525 0.590337397788274 2678/2876 2 hsa04620 Toll-like receptor signaling pathway 3/179 104/7916 0.419254181050604 0.715999023482525 0.590337397788274 5603/5291/1513 3 hsa04137 Mitophagy - animal 2/179 65/7916 0.434464178176999 0.732548435340834 0.603982300100908 6714/6237 2 hsa00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 1/179 25/7916 0.435987536489465 0.732548435340834 0.603982300100908 51604 1 hsa05223 Non-small cell lung cancer 2/179 66/7916 0.442190703661409 0.732548435340834 0.603982300100908 1026/5291 2 hsa04931 Insulin resistance 3/179 108/7916 0.443326506246335 0.732548435340834 0.603982300100908 6196/5291/6945 3 hsa00790 Folate biosynthesis 1/179 26/7916 0.448781634952066 0.732548435340834 0.603982300100908 6697 1 hsa04066 HIF-1 signaling pathway 3/179 109/7916 0.449285759930714 0.732548435340834 0.603982300100908 1026/3098/5291 3 hsa00062 Fatty acid elongation 1/179 27/7916 0.461287095958857 0.732548435340834 0.603982300100908 3030 1 hsa00601 Glycosphingolipid biosynthesis - lacto and neolacto series 1/179 27/7916 0.461287095958857 0.732548435340834 0.603982300100908 10402 1 hsa04390 Hippo signaling pathway 4/179 154/7916 0.461724784960274 0.732548435340834 0.603982300100908 7482/1490/7473/23286 4 hsa05211 Renal cell carcinoma 2/179 69/7916 0.465016874780722 0.732548435340834 0.603982300100908 1026/5291 2 hsa05230 Central carbon metabolism in cancer 2/179 69/7916 0.465016874780722 0.732548435340834 0.603982300100908 3098/5291 2 hsa04725 Cholinergic synapse 3/179 112/7916 0.467007095560977 0.732548435340834 0.603982300100908 2771/5291/5330 3 hsa05145 Toxoplasmosis 3/179 112/7916 0.467007095560977 0.732548435340834 0.603982300100908 2771/5603/330 3 hsa04622 RIG-I-like receptor signaling pathway 2/179 70/7916 0.472503644613195 0.732548435340834 0.603982300100908 5603/8717 2 hsa00650 Butanoate metabolism 1/179 28/7916 0.473510395467459 0.732548435340834 0.603982300100908 3030 1 hsa04744 Phototransduction 1/179 28/7916 0.473510395467459 0.732548435340834 0.603982300100908 808 1 hsa00982 Drug metabolism - cytochrome P450 2/179 72/7916 0.487287668030512 0.737585062360318 0.608134972368323 373156/2948 2 hsa05218 Melanoma 2/179 72/7916 0.487287668030512 0.737585062360318 0.608134972368323 1026/5291 2 hsa00020 Citrate cycle (TCA cycle) 1/179 30/7916 0.497135694556761 0.737585062360318 0.608134972368323 50 1 hsa00030 Pentose phosphate pathway 1/179 30/7916 0.497135694556761 0.737585062360318 0.608134972368323 7086 1 hsa00630 Glyoxylate and dicarboxylate metabolism 1/179 30/7916 0.497135694556761 0.737585062360318 0.608134972368323 50 1 hsa00562 Inositol phosphate metabolism 2/179 74/7916 0.501812739000229 0.737585062360318 0.608134972368323 5291/5330 2 hsa04918 Thyroid hormone synthesis 2/179 74/7916 0.501812739000229 0.737585062360318 0.608134972368323 2876/5330 2 hsa00410 beta-Alanine metabolism 1/179 31/7916 0.508549936336414 0.737585062360318 0.608134972368323 3030 1 hsa00512 Mucin type O-glycan biosynthesis 1/179 31/7916 0.508549936336414 0.737585062360318 0.608134972368323 11226 1 hsa01523 Antifolate resistance 1/179 31/7916 0.508549936336414 0.737585062360318 0.608134972368323 2350 1 hsa05310 Asthma 1/179 31/7916 0.508549936336414 0.737585062360318 0.608134972368323 2207 1 hsa00980 Metabolism of xenobiotics by cytochrome P450 2/179 76/7916 0.516072363693712 0.737585062360318 0.608134972368323 373156/2948 2 hsa05140 Leishmaniasis 2/179 76/7916 0.516072363693712 0.737585062360318 0.608134972368323 5603/1535 2 hsa05220 Chronic myeloid leukemia 2/179 76/7916 0.516072363693712 0.737585062360318 0.608134972368323 1026/5291 2 hsa04215 Apoptosis - multiple species 1/179 32/7916 0.519706507217299 0.737585062360318 0.608134972368323 330 1 hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 2/179 77/7916 0.523100904619723 0.737585062360318 0.608134972368323 93589/3690 2 hsa04612 Antigen processing and presentation 2/179 78/7916 0.530061137873634 0.737585062360318 0.608134972368323 10437/920 2 hsa00051 Fructose and mannose metabolism 1/179 33/7916 0.530611192048362 0.737585062360318 0.608134972368323 3098 1 hsa01521 EGFR tyrosine kinase inhibitor resistance 2/179 79/7916 0.536952544478719 0.737585062360318 0.608134972368323 6714/5291 2 hsa04610 Complement and coagulation cascades 2/179 79/7916 0.536952544478719 0.737585062360318 0.608134972368323 2153/5104 2 hsa00040 Pentose and glucuronate interconversions 1/179 34/7916 0.541269646522971 0.737585062360318 0.608134972368323 51084 1 hsa00640 Propanoate metabolism 1/179 34/7916 0.541269646522971 0.737585062360318 0.608134972368323 3030 1 hsa04130 SNARE interactions in vesicular transport 1/179 34/7916 0.541269646522971 0.737585062360318 0.608134972368323 8673 1 hsa04114 Oocyte meiosis 3/179 128/7916 0.556777338571925 0.746322084829115 0.615338601059827 5603/6196/808 3 hsa05204 Chemical carcinogenesis 2/179 82/7916 0.557209470015028 0.746322084829115 0.615338601059827 373156/2948 2 hsa00250 Alanine, aspartate and glutamate metabolism 1/179 36/7916 0.561869858540551 0.746322084829115 0.615338601059827 2805 1 hsa00350 Tyrosine metabolism 1/179 36/7916 0.561869858540551 0.746322084829115 0.615338601059827 2805 1 hsa00500 Starch and sucrose metabolism 1/179 36/7916 0.561869858540551 0.746322084829115 0.615338601059827 3098 1 hsa04960 Aldosterone-regulated sodium reabsorption 1/179 37/7916 0.571822307185378 0.749212797562767 0.617721978378747 5291 1 hsa05216 Thyroid cancer 1/179 37/7916 0.571822307185378 0.749212797562767 0.617721978378747 1026 1 hsa04068 FoxO signaling pathway 3/179 131/7916 0.572592290152533 0.749212797562767 0.617721978378747 1026/5603/5291 3 hsa04270 Vascular smooth muscle contraction 3/179 132/7916 0.577786399162858 0.752266450395206 0.620239698945017 10398/808/5330 3 hsa00513 Various types of N-glycan biosynthesis 1/179 38/7916 0.581549913101588 0.753436586924718 0.621204470308152 3074 1 hsa00260 Glycine, serine and threonine metabolism 1/179 40/7916 0.600350690609881 0.772329050409919 0.63678120626153 113675 1 hsa04727 GABAergic synapse 2/179 89/7916 0.60200553358948 0.772329050409919 0.63678120626153 6714/2771 2 hsa05162 Measles 3/179 138/7916 0.608114836870221 0.772636313603725 0.637034543135351 8717/868/5291 3 hsa05410 Hypertrophic cardiomyopathy (HCM) 2/179 90/7916 0.608120596638673 0.772636313603725 0.637034543135351 93589/3690 2 hsa05032 Morphine addiction 2/179 91/7916 0.614164510405942 0.774361250999583 0.638456744870578 2771/408 2 hsa00380 Tryptophan metabolism 1/179 42/7916 0.618311265056701 0.774361250999583 0.638456744870578 3030 1 hsa00860 Porphyrin and chlorophyll metabolism 1/179 42/7916 0.618311265056701 0.774361250999583 0.638456744870578 644 1 hsa00071 Fatty acid degradation 1/179 44/7916 0.635468983408528 0.791160519184377 0.652307652399366 3030 1 hsa05150 Staphylococcus aureus infection 2/179 96/7916 0.643320505260395 0.791160519184377 0.652307652399366 6404/3383 2 hsa05414 Dilated cardiomyopathy (DCM) 2/179 96/7916 0.643320505260395 0.791160519184377 0.652307652399366 93589/3690 2 hsa02010 ABC transporters 1/179 45/7916 0.643757988994132 0.791160519184377 0.652307652399366 10347 1 hsa00564 Glycerophospholipid metabolism 2/179 97/7916 0.648940150564055 0.793819812085332 0.65450022529349 9162/79143 2 hsa04925 Aldosterone synthesis and secretion 2/179 98/7916 0.654489795862934 0.794306224558009 0.654901269797678 808/5330 2 hsa04723 Retrograde endocannabinoid signaling 3/179 148/7916 0.655378139654327 0.794306224558009 0.654901269797678 2771/5603/5330 3 hsa00280 Valine, leucine and isoleucine degradation 1/179 48/7916 0.667517056757514 0.805307274895533 0.663971577460395 3030 1 hsa05030 Cocaine addiction 1/179 49/7916 0.675081170489136 0.807028853812013 0.665391010147187 2771 1 hsa05144 Malaria 1/179 49/7916 0.675081170489136 0.807028853812013 0.665391010147187 3383 1 hsa04340 Hedgehog signaling pathway 1/179 50/7916 0.682474137373901 0.808516658240252 0.666617697008173 408 1 hsa04979 Cholesterol metabolism 1/179 50/7916 0.682474137373901 0.808516658240252 0.666617697008173 10577 1 hsa04922 Glucagon signaling pathway 2/179 106/7916 0.696404365145977 0.821319946338081 0.677173940146667 808/5330 2 hsa04330 Notch signaling pathway 1/179 53/7916 0.703664239273322 0.826177209503945 0.681178727867972 5664 1 hsa05206 MicroRNAs in cancer 6/179 310/7916 0.708578261749603 0.828249257067313 0.682887120095524 4318/1026/85414/7473/5291/3690 6 hsa04217 Necroptosis 3/179 162/7916 0.714500313542662 0.831476028591682 0.685547576105209 330/8717/197259 3 hsa01212 Fatty acid metabolism 1/179 57/7916 0.729745668346446 0.84442029819939 0.696220057750948 3030 1 hsa04724 Glutamatergic synapse 2/179 114/7916 0.734049188984699 0.84442029819939 0.696220057750948 2771/5330 2 hsa04978 Mineral absorption 1/179 58/7916 0.735901098473178 0.84442029819939 0.696220057750948 7421 1 hsa04726 Serotonergic synapse 2/179 115/7916 0.738466420478554 0.84442029819939 0.696220057750948 2771/5330 2 hsa05164 Influenza A 3/179 170/7916 0.744629267348561 0.847781373647929 0.698991246633874 8717/5291/3383 3 hsa05010 Alzheimer disease 3/179 171/7916 0.748212803755415 0.848189514602044 0.699327756686096 808/5664/5330 3 hsa00310 Lysine degradation 1/179 61/7916 0.753543283350939 0.85013709714019 0.700933528160413 3030 1 hsa04213 Longevity regulating pathway - multiple species 1/179 62/7916 0.75915954716764 0.85013709714019 0.700933528160413 5291 1 hsa04152 AMPK signaling pathway 2/179 120/7916 0.759628204668991 0.85013709714019 0.700933528160413 5291/55437 2 hsa04927 Cortisol synthesis and secretion 1/179 65/7916 0.775256040975353 0.860305226905138 0.709317097228171 5330 1 hsa05321 Inflammatory bowel disease (IBD) 1/179 65/7916 0.775256040975353 0.860305226905138 0.709317097228171 4772 1 hsa00010 Glycolysis / Gluconeogenesis 1/179 68/7916 0.790282339324631 0.866766733492452 0.714644575142866 3098 1 hsa05031 Amphetamine addiction 1/179 68/7916 0.790282339324631 0.866766733492452 0.714644575142866 808 1 hsa05034 Alcoholism 3/179 184/7916 0.79123644851656 0.866766733492452 0.714644575142866 2771/808/55315 3 hsa04920 Adipocytokine signaling pathway 1/179 69/7916 0.795065654979688 0.866766733492452 0.714644575142866 8717 1 hsa00230 Purine metabolism 2/179 130/7916 0.797557222453131 0.866766733492452 0.714644575142866 100/26289 2 hsa04120 Ubiquitin mediated proteolysis 2/179 136/7916 0.81770000603832 0.882304727346497 0.727455568674719 330/868 2 hsa04151 PI3K-Akt signaling pathway 6/179 354/7916 0.818564081644659 0.882304727346497 0.727455568674719 1026/1435/5291/118788/1436/3690 6 hsa03320 PPAR signaling pathway 1/179 76/7916 0.825644053918049 0.886303617063048 0.730752632039175 1622 1 hsa00983 Drug metabolism - other enzymes 1/179 79/7916 0.837317410007455 0.895180808260002 0.738071829103704 2948 1 hsa04146 Peroxisome 1/179 83/7916 0.851681486289945 0.902813274575 0.744364757104063 373156 1 hsa04742 Taste transduction 1/179 83/7916 0.851681486289945 0.902813274575 0.744364757104063 5330 1 hsa04932 Non-alcoholic fatty liver disease (NAFLD) 2/179 149/7916 0.855328510931221 0.902813274575 0.744364757104063 5291/6945 2 hsa04260 Cardiac muscle contraction 1/179 86/7916 0.861620273453708 0.902813274575 0.744364757104063 93589 1 hsa04911 Insulin secretion 1/179 86/7916 0.861620273453708 0.902813274575 0.744364757104063 5330 1 hsa04512 ECM-receptor interaction 1/179 88/7916 0.867875289098323 0.905319324316853 0.746430981826183 3690 1 hsa04211 Longevity regulating pathway 1/179 89/7916 0.870896536320014 0.905319324316853 0.746430981826183 5291 1 hsa04630 JAK-STAT signaling pathway 2/179 162/7916 0.885772186054285 0.915481673015439 0.754809784435383 1026/5291 2 hsa04974 Protein digestion and absorption 1/179 95/7916 0.887634321745007 0.915481673015439 0.754809784435383 1803 1 hsa05168 Herpes simplex virus 1 infection 7/179 491/7916 0.933926038026761 0.957950888984298 0.78982542777973 6714/330/8717/5291/8764/10308/3690 7 hsa05016 Huntington disease 2/179 193/7916 0.936096496079714 0.957950888984298 0.78982542777973 2876/5330 2 hsa04110 Cell cycle 1/179 124/7916 0.942654151972161 0.960922643289451 0.792275623444575 1026 1 hsa05012 Parkinson disease 1/179 142/7916 0.962275358845183 0.977136754348583 0.805644072026449 2771 1 hsa04714 Thermogenesis 2/179 231/7916 0.969486694107752 0.980673079039765 0.808559752980555 5603/6196 2 hsa04141 Protein processing in endoplasmic reticulum 1/179 166/7916 0.978449428613133 0.985947125384115 0.812908176222244 55741 1 hsa04080 Neuroactive ligand-receptor interaction 3/179 340/7916 0.984915182026827 0.988674400278838 0.815156799909709 10911/3274/2696 3 hsa04740 Olfactory transduction 2/179 448/7916 0.999685971684976 0.999685971684976 0.824235782137703 808/408 2