Supplementary file 1: Alignments of conotoxin precursors and associated venom proteins of Africonus and Varioconus with homologues from other cone snail species Abalde, S. Tenorio, M. J., Afonso, C. M. L., and Zardoya, R. (2020) Comparative transcriptomics of the venoms of continental and insular radiations of West African cones. Proceedings Royal Society B https://doi.org/ 10.1098/rspb.2020.0794 Conotoxin precursor superfamilies [Superfamily A-1] [Framework I] [alpha 4/4] [ /------Signal-------/---------------Pro-------------/ /---CC----C----C/-] V_1278_077 MGMRMMFIVFLLVVLATTVVSFTLDRVLGLASEGRNAKAIDNALDQRDP--KR QTPGCCWNPACGRNRCGRR A_0885_125 MGMRMMFIVFLLVVLATTVVSFTLDRVLGLASEGRNAKAIDNALDQRDP--KR QTPGCCWNPACGRNRCGRR A_1387_284 MGMRMMFIVFLLVVLATTVVSFTLDRVLGLASEGRNAKAIDNALDQRDP--KR QTPGCCWNPACGRNRCGRR A_0025_188 MGMRMMFIVFLLVVLATTVVSFTLDRVLGLASEGRNAKAID------------ ------------------- A_0025_065 MGMRMMFIVFLLVVLATTVVSFTLDHVLGLASEGRNAKAIDNALDQRDP--KR QTPGCCWHPACGKNRCGRR ermineusAXL95592 MGMRMMFIVFLLVVLATTVVSFTLDRVLGLASEGRNAKAIDNALDQRDP--KR QTPGCCWNPACGRNRCGRR ermineusAXL95475 MGMRMMFIVFLLVVLATTVVSFTLDHVLGLASEGRNAKAIDNALDQRDP--KR QTPGCCWHPACGKNRCGRR [alpha 4/7] [ /------Signal-------/---------------Pro-------------/ /-CC----C-------C/----] V_1302_327 MGMRMTFTVFLLVVLATTVVVFSSDR----AFDGRNAAADDKASDPVAR-AVR DGCCSFPPCKGINPHLCA----- V_1258_268 MGMPMMVTVFLLVVLATTVVSFTLDR----ASDGRNAAADDKASDLISQ-IVK NGCCSDPACS------------- A_1387_282 MGMRMMFTMFLLVVLATTVVSITLDR----ASDGSNAAADDKASDLIAQ-IVR RGCCSHPDCKVNNPVVCG----- A_1387_287 MGMRMTFTVFLLVVLATTVVSITLDR----ASDGSNAAADDKASDLIAQ-IVR RGCCSHPDCKVNNPVVCG----- A_1387_289 MGMRMTFTVFLLVVLATTVVSLTSDR----ASDGRNAAADDKASDTIAL-AAR GGCCSNNACRVNNPHVC-R---- A_0039_320 --------------------------------------ADDKASDTIAL-AAR GGCCSNNACRVNNPHVC-R---- A_0885_320 MGMRMTFTVFLLVVLATTVVVFSSDR------------ADDKASDLIAL-TVK -GCCADPPCRVNNPSPCGYIR-- A_0885_126 MGMRMTFTVFLLVVLATTVVVFSSDR----ASDGRNAAADDKASDLIAL-TVK -GCCADPPCRVNNPSPCGYIR-- bandanusP0CE73 MGMRMMFTMFLLVVLATTVVSFASDR----ASDGRNAAAKDKASDLVAL-TV- KGCCSHPACSVNNPDICG----- leopardusAAS99934 MGMRMMFTVFLLVILASTV---TLDR----ASNGMNAAAIRKASALVAQIAYR D-CCDDPACTVNNPGLCT----- chiangiAIF30340 MGMRMMFTMFLLVVLATTVASINLDR----AFDGRNAAADDKASDLIAQ-IVR RGCCSDPRCAWR----CG----- regiusCCB84446 MGMRMMFTVFLLVVLTTTVVSSTSVR----ASDGRNAAADNRASDLIAQ-IVR RGCCSHPACNVNNPHIC------ ermineusP50982 -----MFTVFLLVVLATTVGSFTLDR----ASDGRDAAANDKASDLIALTARR DPCCYHPTCNMSNPQICG----- magusQFQ60962 MGMQMMFTVFLLVVLATTVVSIPSDR----ASDGRNAAANDKASDVITL-ALK -GCCSNPVCHLEHSNLCGRRR-- magusQFQ60960 MGMRMMFIMFMLVVLATTVVTFTSDR----ALDAMNAAASNKASRLIAL-AVR--GCCARAACAGIHQELCGGGR-- betulinusAIF30335 -----MFTVFLLVVLATTVVSFTSDR----AFRGRNSAANDKRSDLAAL-SVR RGCCSHPACSVNHPELCGRRR-- betulinusAGK23276 MGMRMMFIVFLLVVLATTVVSFTSDR----ASDGGNAAA--KASDLIAQ-TIR GGCCSYPACSVEHQDLCDGRR-- A_0855_091 MGMQMTFTVFLLVVLATTVVVFSSDR----ASDGRNAAADDKASDPIAL-TLR SRCCSFPPCAANNARLCGRRR-- A_0055_171 MGMRMTFTVFLLVVLATTVVVFSSDR----SSDGRNAAANDKASDPIAL-TLR GRCCSFPPCAANNARLCGRRR-- A_0039_171 MGMRMTFTVFLLVVLATTVVVFSSDR----SSDGRNAAANDKASDPIAL-TLR GRCCSFPPCAANNARLCGRRR-- A_0885_124 MGMRMTFTVFLLVVLATTVVVFSSDR----ASDGRNAAANDKASDPIAL-TLR GRCCSFPPCAANNARLCGRRR-- A_0520_291 MGMRMTFTVFLLVVLATTVVVFSSDR----ASDGRNAAADDKASDPIAL-TLR GRCCSFPPCAANNARLCGRRR-- A_0048_201 MGMRMTFNVFLLVVLATTVVVFSSDR----ASDGRNAAADDKASDPIAL-TLR GRCCSFPPCAANNARLCGRRR-- A_0025_315 MGMRMTFTVFLLVVLATTVVVFSSDR----ASDRRNAAADDKASDPIAL-TLR GRCCSFPPCAANNARLCGRRR-- V_1302_141 MGMRMTFTVFLLVVLATTVVVFSSDR----ASDGMNAAADDKASDLIAL-TLR DGCCSDPPCKANHPRLCGDIR-- V_1258_054 MGMRMTFTVFLLVVLATTVVVFSSDR----ASDGMNAAADDKASDLIAL-TLR DGCCSDPPCKANHPRLCGDIR-- V_CG13_124 MGMRMMFTVFLLVVLATTVVVFSSDR----ASDGMNAAADDKASDLIAL-TLR DGCCSDPPCKANHPRLCGDIR-- V_1278_078 MGMRMTFTVFLLVVLATTVVVFSSDR----ASDGMNAAADDKASDLIAL-TLR DGCCSDPPCKANNPRLCGDIR-- A_1387_285 MGMRMMFIVFLLVVLATTVVSLTSDR----ASDGRNAAADDKASDLIAL-TVR DGCCSDPPCKATNLRLCGIVS-- A_1387_286 MGMRMTFTVFLLVVLATTVVSLTSDR----ASDGRNAAADDKASDLIAL-TVR DGCCSDPPCKATNLRLCGIVS-- A_0239_404 MGMRMTFTVFLLVVLATTVVVFSSDR----ASDGRNAAADDKASDLIAL-TVR DGCCSDPPCKATNLRLCGIVS-- A_0239_407 MGMRMTFTVFLLVVLATTVVVFSSDR----ASDGINAAADDKASDLIAL-TVR DGCCSDPPCKATNLRLCGIVS-- A_0031_403 MGMRMTFTVFLLVVLATTVVVFSSDR----ASDGINAAADDKASDLIAL-TLR DGCCSDPPCKATNLRLCGIVS-- A_0520_290 MGMRMTFTVFLLVVLATTVVVFSSDR----ASDGRNAAADDKASDPIAL-TVR DGCCSYPLCRMQNLDLCGGRR-- A_0025_318 MGMRMTFTVFLLVVLATTVVVFSSDR----ASDRRNAAADDKASDPIAL-TVR DGCCSYPLCRMQNSNLCGGRR-- A_0855_090 MGMQMTFTVFLLVVLATTVVVFSSDR----ASDGRNAAADDKASDPIAL-TVR DGCCSYPLCRMQNSDLCGGRR-- A_0031_404 MGMRMTFTVFLLVVLATTVVSFTSDR----ASDGRNAAANDKASDPIAL-ILR GGCCSYPPCAVSNPRHCGRRR-- A_0031_405 MGMWMTFTVFLLVVLATTVVSFTSDR----ASDGRNAAANDKASDPIAL-ILR GGCCSYPPCAVSNPRHCGRRR-- A_0239_405 MGMRMTFTVFLLVVLATTVVVFSSDR----ASDGRNAAANDKASDPIAP-ILR GGCCSNPSCATNHPDLCGRRR-- V_CG13_125 MGMRMMFTVFLLVVLATTVVVFSSDR----AFDGRNAAADDKASDLIAL-TLR DGCCSFPPCKGIHPHLCA----- K_0010_384 MGMRMVFTVFLLVVLATTVVSSTPDR----AFDGRNAAADDKASDLLAM-TIR GGCCSYPPCIANNPACAGRR--- K_0010_386 MGMRMMFTVFLLVVLATTVVSFPSDH----ASDGRDAAANDKASDRTAQ-AVR EGCCSDPACSVNHSELC------ V_CG13_071 ---RMMFTVFVLVVLATTAVSFTFDR----ESKQENRRASNRITRGLW----- VECCADPPCRQNHMDHCPAN--- V_1302_140 MGMRMMFTVFVLVVLATTAVSFTFDR----ESKQENRRASNRITRDEW----- DECCANPPCRQNHMEQCSAN--- K_0010_387 MGMRMMFTMFLSVVLATTVVSFTSDH--GPASNHENRRASNRINRGMW----- EECCNDPPCR------------- pulicariusP0C8V0 -----MFTVFLLVVLVTTVVFSTSDH--RPASNHENRRASKRISEMTW----- EECCTNPVCRQHYMHYC------ magusQFQ60961 MGMRMMFTMFLLVVLTTTVVSFNSDR----ESNHENRRTSNQITRGVW----- DECCKDPQCRQNHMQHCPAR--- litteratusQ2I2R6 MGMRMMFTMFLLVVLTTTVVSFNLDR----ESNHENRRTSNQITRGMW----- DECCDDPPCRQNNMEHCPAS--- leopardusA1X8C3 MGMRMMFTMFLLVVLTTTVVSFNSDR----ESNHENRRTSNQITRGMW----- DECCDDPPCRQNNMEHCPAS--- betulinusAMP44588 MGMRMMFTVFLLVVLATTVVSFAADR----ESNHRNRRASNQIPRGLW----- AECCEDPPCRVNNMEHCPAN--- V_CG13_337 ------------------------------ASSRKNRRASNWNARMAS----- IDCCDIPRCYHEHREECLEESS- V_CG13_123 ------------VVLATTVVS---DR----PSSRKNRRASNWNARMAS----- IDCCDIPRCYHEHREECLEESS- imperialisADJ67512 MGMRMMFTVFLLVVLATTVVS---DR----ASNRENRRASNWNTRIAY----- IGCCDIPDCYNKNREQCLDESSG [Superfamily A-2] [Framework IV] [Kappa 4/5/1/3] [ /------Signal-------/---------------Pro-------------/ /CC----C-----C-C---C] A_0025_319 MGMRMTFTVFLLVVLATTVVVFSSDR----ASDRRNAAADDKASDPIAL-TVK GCCSDPSCNLRNSCFCKGKC A_0025_317 MGMRMTFTVFLLVVLATTVVVFSSDR----ASDRRNAAADDKAPDPIAL-TVK GCCSDPSCNLRNSCFCKGKC A_0239_408 MGMRMTFTVFLLVVLATTVVVFSSDR----ASDGRNAAADDKASDPIAL-TVK GCCSDISCRVQHPCSCAHKC A_0031_406 ----MTFTVFLLVVLATTVVVFSSDR----ASDGRNAAADDKASDPIAL-TVK GCCSDISCRVQHPCFCAHRC ermineus AXL95345 ------------VVLATTVVVFSSDR----ASDRRNAAADDKASDPIAL-TVK GCCSDPSCNLRNSCFCKGKC [Kappa 6/2/1/3] [ /------Signal-------/---------------Pro-------------/ /CC------C--C-C---C-------------------] A_0039_003 MGMRMMFIVFLLVALATTVGSFTSDR----ASDGRNAAVNNKASHLIDN-VIR DCCGVKMDLCHPCLCNNSCKQGQGKKRVWEMMKA----- A_0025_187 MGMRMMFIVFLLVALATTVGSFTSDR----ASDGRNAAVNNKASHLIDN-VIR DCCGVKMDLCHPCLCNNSCKQGQGKKRVWEMMKA----- V_1278_079 MGMRMMFIVFLLVALATTVGSFTSDR----ASDGRNAAVNNKASHLIDN-VIR DCCGVKLDMCHPCLCNNSCKQGQGKKRVWEMMKATDKRN A_0885_127 MGMRMMFIVFLLVALATTVGSFTSDR----ASDGRNAAVNNKASHLIDN-VIR DCCGVKLDMCHPCLCNNSCKQGQGKKRVWEMMKATDKRN A_1387_283 MGMRMMFIVFLLVVLATTVVSLTSDR----ASDGRNAAVNNKASHLIDN-VIR DCCGVKLDMCHPCLCNNSCKQGQGKKRVWEMMKTTDKRN ermineusAXL95482 MGMRMMFIVFLLVALATTVGSFTSDR----ASDGRNAAVNNKASHLIDN-VIR DCCGVKLDMCHPCLCNNSCKQGQGKKRVWEMMKATDKRN ermineusAXL95679 MGMRMMFIVFLLVVLATTVVSFTSDR----ASDGRNAAVNNKASHLIDN-VIR DCCGVKLDMCHPCLCNNSCKQGQGKKRVWEMMKATDKRN [Kappa 7/2/1/6-7] [ /------Signal-------/---------------Pro-------------/ /CC-------C--C-C-------C-------] A_0885_321 -------------------------------------------SRLLSH-VVR GCCGKYPNAACHPCGCTVGRPPYCDRPSGGGR A_1387_288 MGMRMMFIVFLLVVLATTVVSFTSDR----ASDDRNT--NDKASRLLSH-VVR GCC----------------------------- ermineusAXL95605 MGMRMMFIVFLLVVLATTVVSFTSDR----ASDDRNT--NDKASRLLSH-VVR GCCGKYPNAACHPCGCTVGRPPYCDRPSGGGR purpurascensADN79118 -----MFTVFLLVVLATTVVSFTSDR----ASDDRNT--NDKASRLLSH-VVR GCCGSYPNAACHPCSCK-DRPSYC----GQGR [Superfamily A2] [Framework I] [alpha 4/7] [ /------Signal--------/---------Pro--------/ /-CC----C-------C--] A_0039_315 MRCLAFLVVALLLFTAMAAAAPFDGRNAAADDKASDLIALTVR DGCCSDPPC----------- A_0885_111 ----------LLLFTAMAAAAPFDGRNATADDKASDTIALAAR GGCCSNNACRVNNPHVCR-- A_0855_236 --------------------GASNRVNAAANGKTSDSISLAVR DNCCPDPSCRQNHPELCG-- A_0885_310 -----------------------NRVNAAANGKISDSISLAVR DACCPSPSCRQNHPELCG-- A_0055_027 MRCLAFLVVTLLLFTAMETTGASNRVNAAANGKTSDSISLAVR DDCCPSPSCRQNHPELC--- A_0885_110 MRCLAFLVVTLLLFTAMETTGASNRVNAAANGKTSDSISLAVR DDCCPDPSCRQNHPELCA-- A_0875_011 MRCLAFLVVTLLLFTAMETTGASNRVNAAANGKTSDSISLAVR DDCCPDPSCRQNHPELCA-- A_0039_029 MRCLAFLVVTLLLFTAMETTGASNRVNAAANGKTSDSITLAVR DDCCPDPSCRQNHPELCG-- V_CG13_072 MRCLAFLVVTLLLFTAMETTGASNRVNAAANGKASDSISLAVR DECCPNPSCRQNHPELCPQD V_1258_159 MRCLAFLVVTLLLFTAMETTGASNRVNAAANGKASDSISLAVR DECC---------------- V_1278_090 MRCLAFLVVTLLLFTAMETTGASNRVNAAANGKASDSISLAVR DECCPNPSCRQNHPELCP-- A_0025_004 MRCLAFLVVTLLLFTAMETTGASNRVNAAANGKTSDSISLAVR DDCCPSPSCRQNHPELCA-- A_1387_008 MRCLAFLVVTLLLFTAMETTGASNRVNAAANGKTSDSISLAVR DDCCPNPSCRQNHPELCA-- A_0031_013 MRCLAFLVVTLLLFTAMETTGASNRVNAAANGKTSDSISLAVR DACCPSPSCRQNHPELCA-- A_0048_339 MRCLAFLVVTLLLFTAMETTGASNRVNAAANGKTSDSISLAVR DGCCPDPSCRQNHPELCG-- K_0010_385 MRCLAFLVVTLLLFTAMATTGASNRVNSAASGKASDSISLAVR-DDCCPDPSCRQNHPELC--- ermineusAXL95539 MRCLAFLVVTLLLFTAMETTGASNRVNAAANGKTSDSISLAVR DDCCPDPSCRQNHPELCA-- betulinusAMP44761 ----AFLVVTLLLFTATATTGAANRVNAAANGKASDSISLAVR DDCCPDPACRQNHPELCSSG pulicariusP0C8U6 MRCLAFLVVTLLLFTATATTGASNGMNAAASGEAPDSISLAVR DDCCPDPACRQNHPELCSTR andremeneziATF27378 MRCLAFLVVTLLLFTAMATTGASNRVNAAANGKASDLISLAVR NGCCSNPACRNGNPGLCGSG praecellensATF27573 MRCLAFLVVTLLLFTAMATTGASKRVNAAANGKASASISLAVR DSCCKNPPCRWNNPHTCFPS [Superfamily B1 (Conantokin)] [No Framework] [ /-------Signal------/--------------------------Pro-----------------------------/ /----------------------------] A_0055_115 MQLYTYLYLLMPLVAFHLILGTGTLAHGDSLTERRSADATALKPEPVLLQKSAARSTDDNGEDRLTQMKRTLKKRGEDIK --DKRT-GVLEALYE---FFIKAKR----- A_0520_123 ------------------------------------ADATALKPEPVLLQKSAARSTDDNGEDRLTQMKRTLKKRGEDIN --DKRA-GVGEALYE---FFIKAKR----- A_0520_124 MQLYTHLYLLVPLVAFHLILGTGTLAHGDALIERRSADATALKPEPVLLQKSAARSTDDNGKDRLTQMKRTLKKRGEDIN --DKRA-GVGEALYE---FFIKAKR----- A_0055_113 MQLYTHLYLLVPLVAFHLILGTGTLAHGDSLTERRSADATALKPEPVLLQKSAARSTDDNGKDRLTQMKRTLKKRGEDIK --DKRT-GVLEALYE---FFIKAKR----- A_1387_269 MQLYTYLYLLMPLVAFHLILGTGTLAHGDSLTERRSADATALKPEPVLLQKSAARSTDDNGEDRLTQMKRILKKRGNTA- --EEIR-EFEENVIE---LDNA-------- A_0520_125 MQLYTYLYLLMPLVAFHLILGTGTLAHGDSLTERRSADATALKPEPVLLQKSAARSTDDNGEDRLTQMKRILKKRGNTA- --EEIR-EFEEKVIE---LYNAEK------ A_0048_062 MQLYTYLYLLMPLVAFHLILGTGTLAHGDSLTERRSADATALKPEPVLLQKSAARSTDDNGEDRLTQMKRILKKRGNTA- --EEIR-EFEENVLE---LYNAEK------ A_0520_122 MQLYTHLYLLVPLVAFHLILGTGTLAHGDALIERRSADATALKPEPVLLQKSAARSTDDNGKDRLTQMKRILKKRGNTA- --EEIR-EFEEKVIE---LYNAEK------ A_0855_104 MQLYTYLYLLMPLVAFHLILGTGTLAHGDSLTERRSADATALKPEPVLLQKSAARSTDDNVEDRLTQMKRILKKRGNTAR GYEEDR-EVAENVRE---LEDAGK------ V_CG13_028 MQLYTYLYLLVPLVAFYLILGTGTLAHGDALTERRSADATALKPEPVLLQKSAARSTDDNGEDRLTQMKRILKKRGNTAR GFEEQR-EVAENVRE---LHDAGK------ V_1302_012 MQLYTYLYLLVPLVAFYLILGTDTLAHGDALTERRSADATALKPEPVLLQKSAARSTDDNGEDRLTQMKRTLKKRGNTAR GYEEDR-EVAENVRE---LNDAGK------ V_1258_116 MQLYTYLYLLVPLVAFYLILGTGTLAHGDALTERRSADATALKPEPVLLQKSAARSTDDNGEDRLTQMKRILKKRGNTAR GFEEQR-EVAENVRE---LNDAGK------ A_0025_087 MQLYTYLYLLMPLVAFHLILGTGTLADGDSLTERRSADATALKPEPVLLQKSAARSTDDNGEDRLTQMKRILKKRGKKAR GFEESR-EAAENVRE---LMNAGK------ A_0885_037 MQLYTYLYLLMPLVAFHLILGTGTLAHGDSLTERRSADATALKPEPVLLQKSAARSTDDNVEDRLTQMKRILKKRGNTAR GYEEDR-EVAENVRE---LEDAGK------ V_1258_117 MQLYTYLYLLVPLVAFYLILGTGTLAHGDALTERRSADATALKPEPVLLQKSAVRSTDNNGKDRLTQRKRILKKRGNTAR GYEENR-EIAETVRE---LDEIGKR----- A_0055_114 MQLYTHLYLLVPLVAFHLILGTGTLAHGDSLTERRSADATALKPEPVLLQKSAARSTDDNGEDRLTQMKRILKKRGNTAR GTEELV-EFAEKMSE---LDIAGK------ A_0039_018 MQLYTYLYLLMPLVAFHLILGTGTLAHGDSLTERRSADATALKPEPVLLQKSAARSTDDNGEDRLTQMKRILKKRGNTAR GTEELV-EFAEKMGE---LDITGK------ A_0031_221 MQLYTYLYLLMPLVAFHLILGTGTLAHGDSLTERRSADATALKPEPVLLQKSAARSTDDNGEDRLTQMKRILKKRGNTAR GTEELV-EFAEKMGE---LDITGK------ A_0239_118 MQLYTYLYLLMPLVAFHLILGTGTLAHGDSLTERRSADATALKPEPVLLQKSAARSTDDNGEDRLTQMKRILKKRGNTAR GTEELV-EFAEKMSE---LDIAGK------ A_0239_119 MQLYTYLYLLMPLVAFHLILGTGTLAHGDSLTERRSADATALKPEPVLLQKSAARSTDDNGEDRLTQMKRILKKRGNTAR GTEEFI-EFEEKMRE---LDIAEKLKKD-- K_0010_066 MQLYTHLYLLVLLVAFHLIQGTGTLDHGDALTERRSADATARKPEPVLLQKSAVRSTDNNGKDRLTQRKRILKKRGNTAR GYEEDR-EIAETVRE---LDEIGKR----- ermineusAXL95339 MQLYTYLYLLMPLVAFHLILGTGTLADGDSLTERRSADATALKPEPVLLQKSAARSTDDNGEDRLTQMKRILKKRGKKAR GFEESR-EAAENVRE---LMNAGK------ ermineusAXL95507 MQLYTYLCLLAPLVTFHLILGTGMLAHGDTLTERRSVDATALKPEPVLLQKSAARSTDANGKDRLTQRKRILKKRGNMAR SSEEDI-ELIEALEE------SGKR----- ermineusAXL95496 MQLYTYLYLLVPLVTFHLILGMGTLDHGGALTERRSADATALKPEPVLLQKSDARSTDDNDKDRLTQMKRILKKRGNKAR GEEEHS-KYQECLRE---IRVNNVQQEC-- purpurascensP0C8E3 MQLYTYLYLLVPLVTFHLILSTGTLAHGGTLTERRSTDTTALKPEPVLLQKSDARSTDDNDKDRLTQMKRILKKRGNKAR GEEEHS-KYQECLRE---IRVNKVQQEC-- magusQFQ60970 MQLYTHLYLLVPLVTFHLILGTGTLDHGGALTERRSADATALKPEPVLLQKSAARSTDDNGKDRLTQMKRILKKRGNKAR GEPEAR-SIPEAVRQQECIRNNNNRPWCPK magusQFQ60972 MQLYTHLYLLVPLVTFHLILGTGTLDHGGALTERRSADATALKPEPVLLQKSAARSTDDNGKVRLTQMKRILKKRGNKAR GEPEVAQMSDEILRE-----IEAQK---PK geographusBAO65541 MHLYTYLYLLVPLVTFHLILGTGTLDHGGALTERRSADATALKAEPVLLQKSAARSTDDNGKDRLTQMKRILKQRGNKAR GEEEVQ-KSQEAINE---ASKGQG------ flavidusAFU50789 MQLYTHLYLLVPLVAFHLILGTGMLAHGDALTERRSADATALKPEPVLLQKSAARSTDDNDRDRLTQRKRILKKRGNTAR GNEDHR-ETAETIRE---LQVP-------- betulinusAMP44595 MQLYTHLYLLVPLVTFYLILGTGTLGHGGALTERRLADATALKPEPVLLQKSAARSTDDNGKDRLTQMIRILKKRGNMAR GGEEVR-ESAEALHE---ITP--------- gloriamarisGFNK01000004 MQLYTHLCLLVPLVTLYVILGTGTLAHGGALTERRLAHARAIEPDPV-LQKSAARSTDDNGKDRMTQRKRILKKRGNTAR GAKEDR-NNAEAVRE--RLEEIGKR----- [No signal no Framework] A_0855_003 MQSFTCMCLLVPLMLFFQLTQRSDTADHGGAATDV----RSADRTLKRFLHDFRRAPKRRSDGRYNRKRDISVSLDMQILAERVREVHEQSREQ--------TVAASMETLREIGR- V_1302_050 MQSFTCMCLLVPLMLFFQLTQRSDTADHGGAATDV----RSADRTLKRFLHDFRRASKRRSD------------------------------------------------------- V_1278_034 MQSFTCMCLLVPLMLFFQLTQRSDTADHGGAATDV----RSADRTLKRFLHDFRRAPKRRSDGRYNRKRDISVSLDMQILAERVREVQEQSREQ--------TVAASMERLQEIGR- V_1278_033 MQSLTCMCLLVSLLLFFQLTQRSDTADHGGAATDV----RSADRTLKRFLHDFRRAPKRRSDGRYNRKRDISVSLDMQILAERVREVQEQSREQ--------TVAASMERLQEIGR- V_1302_049 MQSLTCMCLLVPLLLFFQLTQRSDTADHGGAATDV----RSADRTLKRFLHDFRRAPKRRSDGRYNRKRDISVSLDMQILAERVREVQEQSREQ--------TVAASMESLREIGR- V_CG13_026 MQSLTCMCLLVPLLLFFQLTQRSDTADHGGAATDI----RSADRTLKRFLHDFRRAPKRRSDGRYNRKRDISVSLDTEILVERVREGQEQGREQ--------TVAASMESLREIGR- V_CG13_027 MQSLTCMCLLVPLMLFFQLTQRSDTADHGGAATDV----RSDDRTLKRFLHDFRRAPKRRSDGRYNRNLDISVSVPLETLAEKVR---EESREH--------TVAASRDRLREIGR- V_1258_031 MQSFTCMCLLVPLMLFFQLTQRSDTADHGGAATDV----RSDDRTLKRFLHDFRRASKRRSDGRYNRNLDISVSVPLETLAEKVR---EESREH--------TVAASRDRLREIGR- A_0055_087 MQSFTCTCLLVPLMLFVQLTQQSDTADHGGAATDV----RSDDRTLKRFLHDFRRASKRRSDGRYNRKGKLSVMLPIDIIADKIR---EQGREQ--------TVAASNERLQEIGRW A_0055_083 MQSFTCTCLLVPLMLFFQLTQRSDTADHGGAATDV----RSDDRTLKRFLHDFRRASKRRSD------------------------------------------------------- A_0039_051 MQSFTCTCLLVPLMLFFQLTQRSDTADHGGAATDV----RSDDRTLKRFLHDFRRASKRRSDGRYNRKGKLSVMLPIDIIADKIR---EQGREQ--------TVAASNERLQEIGR- A_0055_086 MQSFTCTCLLVPLMLFVQLTQQSDTADHGGAATDV----RSDDRTLKRFLHDFRRASKRRSDGRYNRKRNLSVSSDMDILADKIR---EQGREQ--------T----NERLQEIGRW A_0039_050 MQSFTCTCLLVPLMLFFQLTQRSDTADHGGAATDVRSDDRSDDRTLKRFLHDFRRASKRRSDGRYNRKRNLSVSSDMDILADKIR---EQGREQ--------T----NERLQEIGR- V_1258_032 MQSFTCMCLLVPLFL-FQLTQRSDTADHGGAATDV----RSADHTMKRFLHDFRRTPKRRSD---NRKRDISVSLDTELLVETVRVAQEQSREQAEASREQASVAASMERLQEIGR- A_0055_085 MQSFTCTCLLVPLMLFFQLTQRSDTADHGGAATDVRSDDRSDDRTLKRFLHDFRRASKRRSDGRYNRKGKLSVMLPIDIIADKIR---EQGREQ--------TVAASNERLQEIGRW A_0875_004 MQSFTCTCLLVPLMLFFQLTQRSDTADHGGAATDVRSDDRSDDRTLKRFLHDFRRASKRRSDGRYNRKLDISVTLPIDIIADKIP---EQGREQ--------TVAASNERLREIGR- A_0055_084 MQSFTCTCLLVPLMLFFQLTQRSDTADHGGAATDVRSDDRSDDRTLKRFLHDFRRASKRRSDGHYNRKQNFSVSSSMDILAEGVR-------EQ--------TVAASMETLREIGR- A_0039_049 MQSFTCTCLLVPLMLFFQLTQRSDTADHGGAATDVRSDDRSDDRTLKRFLHDFRRASKRRSDGHYNRKQNFSVSSSMDILAEGVR-------EQ--------TVAASMETLREIGR- A_0520_048 MQSFTCTCLLVPLMLFFQLTQRSDTADHGGAATDV----RSADRTLKRFLHDFRRASKRRSDGRYNRKRDISVSLDMQILAERVREVH----EQ---SREQ-TVAASMETLREIGR- A_0048_322 MQSFTCTCLLVPLMLFFQLTQRSDTADHGGAATDV----RSADRTLKRFLHDFRRAPKRRSD------------------------------------------------------- A_0239_304 MQSFTCMCLLVPLMLFVQLTQQSDTADHGGAATDV----RSDDRTLKRFLHDFRRASKRRSDGRYNRKRDMSRSLDLEILAENIR-------EQ---GREQ-EVAASTERLQQTGR- A_0025_040 MQSFTCMCLLVPLMLFVQLTQQSDTADHGGAATDV----RSDDRTLKRFLHDFRRASKRRSDGRYNRKRDMSRSLDLQILAENIR-------EQ---RREQ-EVAASTERLQQIGR- A_0025_041 MQSFTCMCLLVPLMLFVQLTQQSDTADHGGAATDV----RSDDRTLKRFLHDFRRASKRRSDGRYNRKRDMSRSLDLQILAENIR-------EQ---DREQ-SVADSMETLREIGR- A_0520_049 MQSFTCTCLLVPLMLFFQLTQRSDTADHGGAATDV----RSDDRTLKRFLHDFRRASKRRSDGRYNRKRNLSVASPIGIIAEKIR-------DQ---GGQQ-RSAALKERLEELGL- A_0239_306 MQSFTCMCLLVPLMLFFQLTQRSDTADHGGAATDVRSDDRSDDRTLKRFLHDFRRASKRRSDGRYNRKRDMSRSLDLEILAENIR-------EQ---GREQ-EVAASTERLQQTGR- A_0239_305 MQSFTCMCLLVPLMLFFQLTQRSDTADHGGAATDVRSDDRSDDRTLKRFLHDFRRASKRRSDGRYNRKRNLSVTLPIDIIADKIR-------EQ---GREQ-TVAASMERLQEIGR- A_1387_246 MQSFTCTCLLVPLMLFFQLTQRSDTADQGGAATDVRSDDRSDDRTLKRFLHDFRRASKRRSDGRYNRKRNLSVTLPIDIIADKIR-------EQ---DREQ-TAAASMAELQQIGR- A_0239_303 ---------------------------------------------LKRFLHDFRRASKRRSDGRYNRKRDISVSLDMQILADKIR-------EQ---GREQ-TVAASMERLQEIGR- K_0010_466 MQSFTCLCLLVPLLL-FQLTQRSDTADHGGAATDV----RSADHTMKRFLHDFRRTPKRRSDNRKRDLSVSLDTEILAERVRAAQ-------EQAEASREQASVAASMERLQEIGR- betulinusAMP44762 -------CLLVPLLL-FHLTQRSDTADHGGAATDV----RSADHTLKRFLHDFRRTLKRRSDGHYARKRETSVSLDTQLLAERVR-------EGQEQGREQ-EVAASMERLYEKGR- flavidusAFU50794 MQSFTCMCLLVPL-LFFHLTQRSDTAGHGGAATDV----RSADHVLKRFYHDFRRAPKRRSNDRYNRRQSTSVSLPLEILAEQTR-------ER---SRE-----ASVEHLREIGR- magusQFQ60981 MQSFTCMCLLVPLLLFFHLTQVSDTADHGGAATDV----RSADRTLKRFPHDFRRAPKRRSDGHYDRNRKTSVQLDTELLVEGVR-------EG---QEE--RAEASYEKLLEIGR- eburneusADZ74131 MQSFTCMCLLVPLLLFFHLTQVSDTADHGGAATDV----RSADRTLKRFPHDFRRAPKRRSDGHYDRNRKTSVQLDTELLVEGVR-------EG---QEE--RAEASYEKLLEIGR- betulinusAMP44603 MQSFTCMCLLVPLLL-FHLTQRSDTADHGGAATDV----RSADRTLKRFLHDFRRAPKRRNHGRYDRNSKLSVHFDLQRLAEIYR-------EG---QME--RFRASVEKMYEIGR- magusQFQ60980 MQSFTFMCLLVLLLLFFHPTQRSVTADHEAAAKEVRSDNRNLKRLLHDFHRDL----KRRNDCRYGRKGKLSVQLDTQLLVERVC-------ES---RER--SKEKSVEWLKSLGR- andremeneziATF27383 MQSFTCWCLLVPLLLFLYLTQRSDTADHEGAATEV----RSADHIPK--HDVR-QALKRRYDGRYGRKQHVS-RSPES-IAERVR---EQHREE-VAEKRNEKAAEKKEELDELGR- A_0039_052 ---------LVPLMLFFHLTH-SVTADHEGAATEV----RSADHTLKRFVHPVHQAPKRGPVQSRASTLHDLHDDDNDNDGDKKKKRTGNLSVTLGLDVLAE-LNNQRKKIEEVEAKLDRLGR- A_0875_005 MQFFTCLCLLVPLMLFFHLTH-SVTADHEGAATEV----RSADHTLKRFVHPVHQAPKRGPVQSRASTLRDLHDDDNDNDGDKKKKRTGNLSVTLGLDVLAE-LNNQRKKIEEVEAKLDRLGR- A_0239_307 MQFFTCLCLLVPLMLFFHLTH-SVTADHEGAATEV----RSADHTLKRFVHPVHQAPKRGPVQSRASTLHDLHDDDN-NDGDKKKKRTGDLSVNLDLDVLAEQLINQGEKIEEAEAKLDRLGR- A_0031_017 MQFFTCLCLLVPLMLFFHLTH-SVTADHEGAATEV----RSADHTLKRFVHPVHQAPKRGPVQSRASTLHDLHDDDN-NDGDKKKKRTGDLSVNLDLDVLAEQLINQGEKIEEAEAKLDRLGR- betulinusAMP44648 MQFFTCLCLLVPLMLFFHLTH-SVTADHAGAATEV----RSADHTLKRFVHHVHQAPKRGPVQPRASTIHGLHNDDNDNDGN-KKKRTGDLSVNLDLSVLAEGLNKQEEAAEAAQATLDGLGR- [Superfamily B2] [No Framework] [ /----Signal-----/--------------------Pro-----------------------------------------/ /----------------------------------------------------------------------------------] A_0855_048 MLRLII-AAVLASACLAYPQRREGAPAEAANLQGFDQG------MPNMQGMGL-QPMQAMPGMGAGQMLPFNPNF-GLGYKR AFDENLEKRREHSKFN-DDNKSPFESEDSLGN---FMNFM-KDNGN-SFPFANMDNG-APDLDNFQPSAE-NEDSKFSFFDQQQ A_0885_045 ---------------------------------------------------------------------------------- ---ENLEKRREHSKFN-DDNKSPFGSNDDLGD---FMNFM-KGSSN-NLPFANMDSA-AADVGNFEPSAE-NEDGKFRFFDKQQ A_0885_046 MLRLII-AAVLASACLAYPQRREGAPAEAANLQGFDQG------MPNMQGMGL-QPMQAMPGMGAGQMLPFNPNF-GLGYKR AFDENLEKRREHSKFN--DNKSPFESEDSLGN---FMNFM-KDNGN-SFPFANMDNG-APDLGNFQPSAE-NEDSQFGFFDRQQ A_0039_187 MLRLII-AAVLASACLAYPQRREGAPAEAANLQGFDQG------MPNMQGMGL-QPMQAMPGMGAGQMLPFN--F-GLGYKR AFDENLEKRREHSKFN-DDNKSPFESEDSLGN---FMNFM-NDNGN-SFPFANMDNG-APDLGNFQPSAE-NEDSKFNFFDQQQ V_CG13_085 MLRLII-AAVLASACLAYPQRREGAPADAANLQGFDQGMQ---AMPNMQGMGM-QPMQAMPGMGAGQMLPFNPNF-ALGYKR AFDENLEKRREHSKFN-DDNMSPFDSGDGLGN---FMNFM-KDNGN-NLPFANMDSA-ATDLGNFQPSAE-NEDGKFRFFDQQQ V_1302_053 MLRLII-AAVLASACLAYPQRREGAPADAANLQGFDQGMQ---AMPNLQGMGM-QPMQPMPGMVAGQMLPFNPNF-ALGYKR AFDENLEKRREHSKFN-DDNMSPFDSEDGIGN---FMNFM-KDNGN-NLPFANMDSA-ATDLGNFQPSAE-NEDGKFRFFDQQQ V_1278_018 MLRLII-AAVLASACLAYPQRREGAPADAANLQGFDQGMQ---AMPNMQGMGM-QPMQAMPGMGAGQMLPFNPNF-ALEYKR AFDENLEKRREHSKFN--DNMSPFDSENGVGS---FANFM--------------DSA-ATDLGNFQSSAK-SEDGKFGFFDQQR V_1258_079 MLRLII-AAVLASACLAYPQRREGAPADAANLQGFDQGMQ---AMPNLQGMGM-QPMQPMPGMVAGQMLPFNPNF-ALGYKR AFDENLEKRREHSKFN-DDNMSPFDSEDGLGN---FMNFM-KDNGN-NLPFANMDSA-ATDLGNFQPSAE-NEDGKFRFFDQQQ V_1258_080 MLRLII-AAVLASACLAYPQRREGAPADAANLQGFDQGMQ---AMPNLQGMGM-QPMQPMPGMVAGQMLPFNPNF-ALGYKR AFDENLEKRRQPSKFN-DDNKSPFGSSDDLGD---IMNFM-KGSGN-SLPFANIDSA-AADVGNFEPSAE-NED---------- A_0025_091 MLRLII-TAVLASACLAYPQKREGAPAEAANLQGFDQ------AMPNMQGMGLQPMQAMPGMG-TGQMLPFNPNF-GLGYKR AFDENLEKRREHSKFN-DDNKSPFESEDSLEN---FMNFM-KDNGN-SLPFANMDNG-APDLGNFQPSAE-NEDSKFNFFDQQQ A_0520_164 MLRLII-TAVLASACLAYPQRREGAPAEAANLQGFDQ------AMPNMQGMGLQPMQAMPGMG-ASQMLPFNPNF-GLGYKR AFDENLEKRREHSKFV-DENKSPFESEESPENFMDFMNFM-KDNGN-SLPFANMDND-APDLDNFQPSAE-NEDSKFNFFDQQQ A_0048_168 MLRLII-TAVLASACLAYPQRREGAPAEAANLQGFDQ------AMPNMQGMGLQPMQAMPGMG-AGQMLPFNPNF-GLGFKR AFDENLGKRREHSEFV-DANKSPFESEESPENFMDFMNFM-KDNGN-SLPFANMDND-APDLDNFQPSAE-NEDSKFNFFDQQQ A_0875_101 MLRLII-AAVLASACLAYPQRREGAPAEAANLQGFDQGMQ---SMPNMQGMGLQPMQAMPGMG-AGQMLPFNPNF-GLGYKR AFDENLEKRREHSKFN-DDNKSPFESEDSQGN---FMNFM-KDNGN-SFPFANMDNG-APDLGNFQPSAE-NEDSKFNFFDRQQ A_0039_190 ---------------------REGAPAEAANLQGFDQGMQ---SMPNMQPM--QSMQAMPGMD-PGQMLPFNPNF-GLGYKR AFDENLEKRREHSKF--DDNKFPFESEDSLGN---FMNFM-NDNGN-SFPFANMDNG-APDLGNFQPSAE-NEDSKFNFFDQQQ A_1387_268 MLRLII-AAVLASACLAYPQRREGAPAEAANLQGFDQGMQ---SMPNMQPM--QSMQAMPGMG-AGQMLPFNPNF-GLGYKR AFDENLEKRREHSKFN-DDNKSPFESEDSLGN---FMNFM-KDNGN-SFPFANMDNG-APDLGNFQPSAE-NEDSKFNFFDQQQ A_0239_170 MLRLII-AAVLASACLAYPQRREGAPAEAANLQGFDQGMQ---SMPNMQPM--QSMQAMPGMD-PGQMLPFNPNF-GLGYKR AFDENLEKRREHSKF--DDNKFPFESEDSLGN---FMNFM-KDNGN-SLPFANMDNG-APDLGNFQPSAE-NEDSKFNFFDQQQ A_0031_223 MLRLII-AAVLASACLAYPQRREGAPAEAANLQGFDQGMQ---SMPNMQPM--QSMQAMPGMD-PGQMLPFNPNF-GLGYKR AFDENLEKRREHSKF--DDNKFPFESEDSLGN---FMNFM-KDNGN-SLPFANMDNG-APDLGNFQPSAE-NEDSKFNFFDQQQ K_0010_196 -------------------QGRDGAPADAANLQGFEQGMQGMPAMPNM--MAMQGMQSMPGMA-GGQMLPFNPNF-AMGYKR AFDENLEKRRQHSKFN-DDNKSPFESEDSLGN---FMNFM-KDNGN-SFPFANMDNG-APDLDNFQPSAE-NEDSKFNFFDQQQ A_0520_163 MLRLII-AAVLASACLAYPQRRDGAPADAANLQGFEQGMQGMPAMPNM--MAMQGMQSMPGMA-GGQMLPFNPNF-AMGYKR AFDENLEKRRQHSKFN-DDNKSPFGSNDDLGD---FMNFM-KGSSN-NLPFANMDSA-AADVGNFEPSAE-NEDGKFRFFDKQQ A_0048_169 MLRLII-AAVLASACLAYPQRRDGAPADAANLQGFEQGMQGMPAMPNM--MAMQGMQSMPGMA-GGQMLPFNPNF-AMGYKR AFDENLEKRRQHSKFN-DDNKSPFGSNDDLGD---FMNFM-KGSSN-NLPFANMDSA-AADVGNFEPSAE-NEDGKFRFFDKQQ K_0010_197 MLRLII-AAVLASACLAYPQRRDGAPADAANLQGFEQGMQGMPAMPNM--MAMQGMQSMPGMA-GGQMLPFNPNF-AMGYKR AFDENLEKRRQHSKFN-DDNKSPFGSNDDLGD---FMNFM-KGSSN-NLPFANMDSA-AADVGNFEPSAE-NEDGKFRFFDKQQ A_0055_208 MLRLII-AAVLASACLAYPQRREGAPAEAANLQGFDQG------IPNRQGMGLQPMQAMPGMG-AGQMLPF--NF-GLGYKR AFDENLEKRREHSKFN-DDNKSPFESEDSQGN---FMNFM-KDNGN-SFPFANMDND-APDLGNFQPSAK-NEDSKFNFFDQQQ A_0031_222 MLRLII-AAVLASACLAYPQRREGAPAEAANLQGFDQG------IPNRQGMGLQPMQAMPGMG-AGQMLPF--NF-GLGYKR AFDENLEKRRE------------------------------------------------------------------------- A_0039_319 -----------------------GAPAEAANLQGFDQG------IPNRQGMGL-QPMQAMPGMGAAQMLPFNPNF-GLGYKR AFDENLEKRREHSKFN-D------------------------------------------------------------------ V_1278_200 ------------------------------NLQSFDPAAQ---AMPAM-----AGMQPMPAMA-GGQFLPFNPNF-GMAYKR DMDESLEKRRQHSQFNADNESPFEADDNLGGF---MNFMK-GSGNN-------------------------------------- A_0025_201 MLRLII-AAVLASACLAFPERRDGVPAEQANLQSFDPAAQ---AMPAM-----AGMQPMPGMT-GGQFLPFNPNF-GMAYKR DMDESLEKRRQHSQFN-ADNESPFEADDNLGG---FMNFM-KGSGN-NVPFANMDSD-ATDLGNFQPSAE-NEDGKFRFF---- ermineusAXL95472 MLRLII-AAVLASACLAFPERRDGVPAEQANLQSFDPAAQ---AMPAM-----AGMQPMPGMT-GGQFLPFNPNF-GMAYKR DMDESLEKRRQHSQFN-ADNESPFEADDNLGG---FMNFM-KGSGN-NVPFANMDSD-ATDLGNFQPSAE-NEDGKFRFFDKQQ betulinusAMP44597 MLRLII-AAVLASACLAYPQKRDGAPADTANLQPFNQGMQ---AMPAFPNM--QGMQGMPGMA-GGQFLPFNPNL-GIGYKR DVDENLEKRRQHSKFN-EGNKSPFDAEGGFGN---FMNFM-KENSN-NLPFANMDSA-ATDLGNFEPSAE-NEDGKFRFFDKQQ geographusBAO65597 MLRLII-AAVLASACLAYPQRRDGVPEDASNLQGFDQGMQ---PMPNMQGM--QGM-PMPGMT-GGQFLPFNPNM-AMPYKR --DEDLEKRRHRYKFNGDSDASPFQSEDGFDN---FMDFM-KDNSNENLPFNNVEGA-ANDLGQFEPSAE-NEDGKFRFFDKQQ consorsP0DKQ7 MLRLIIAAAVLVSACLAYPQRREGAPADAANLQSFDPALM------SMQGM--QGGQ-MPGMA-GGQFLPFNPNL-QMGYKR DFDENLEKRKQHSQFNADENKAPFDSEE---N---FMNFLHNEKGD-KHPFANVDSA-DTDLGQFEPSAE-NKNGEFRFFDKEQ magusQFQ60978 MLRLIIAAAVLLSACLAYPQRREGAPADAANLQSFDPALM------PMQGM--QGGQ-MAGMA-GGQFLPFNPNL-QMGYKR-DFDENLEKRKQHSQFNADENKAPFDSEE---N---FMNFLHNEKGD-KHPFANVDSA-ATDLGQFEPSAE-NEDGKFRFFDKEQ gloriamarisGFNK01000005 MLRLII-AAVLVCACLAYPQKRDGAPADAANLQ----GMM---AMPNMQGM--QPMQPMPMMGMQGQFMPFNPGFGGMGYKR DLDEDPEQKRHHSQFN-EDNISPFNTDEGLGN---FMNFM-NDNGN-SLPFANVDSD-DLGLDSFQPSAG-NEEGKFRFFDGQQ andremeneziATF27381 --------------------------------------------MPNMQGM--QGMPGMPGMP-AGQFLPFNPYP-GFGFKR VADENLEKRKHQSQFN--DNQSPFGSSADGLGMFNFENFM-KENAD-KLPFANMEGADTADLGNFAPSGNDQQEDQFRFFDEQQ [Superfamily C (Contulakin-G)] [No Framework] [ /-----Signal---------/---------------Pro----------------/ /-------C----C----/-----------] V_CG13_169 MQTAYWVMVMMMVWITAPLSEGGKLNDVIRGLVPDDVTPKRILQSLISRRRFD--GR TLF--VPTCILKTCPSG-------------- V_1302_036 MQTAYWVMVMMMVWITAPLSEGGKLNDVIRGLVPDDVTPKRILQSLISRRRFD--GR TLF--VPTCIWNTCLSG-------------- V_1278_006 MQTANWVIVMMMVWITAPLSEGGELNDVIRGLVPDDVSPKRILQSLISRRRFD--GR TLF--VPTCIWSTCSSG-------------- A_0055_156 MQTAYWVMVMMMVWITAPLSEGGKLNNVIRGLVPDDVTPKRISQSLISRRRFD--SR IMF--VPSCIWKTCPSYL-HGDNYDLKEKDK A_0039_028 MQTAYWVMVMMMVWITAPLSEGGKLNNVIRGLVPDDVTPKRISQSLISRRRFD--SR IMF--VPSCIWKTCPSYL-HGDNYDLKEKDK A_0855_016 MQTAYWVMVMMMVWITAPLSEGGKLNDVIRGLVPDDVTPKRISQSLISRRRFD--SR VML--VPSCIWKTCPSYHPHGDNYDLKEKDK A_0031_390 MQTAYWVMVMMMVWITAPLSEGGKLNNVIRGLVPDDVTPKRISQSLISRRRFD--SR IMF--VPSCIWKTCPSYL-HGDNYDLKEKDK A_0239_359 MQTAYWVMVMMMVWITAPLSEGGKLNNLIRGLVPDDVTPKRISQSLISRRRFD--SR IMF--VPSCIWKTCPSYL-HGDNYDLKEKDK V_1258_265 ------------------------LNDVIRGLVPDDLTQQLILQSLVSRRHPDSPVP R----VYICIWKVCPPPPWRR-PNGKG---- K_0010_455 MQTAYWVMVVMMVWITAPLSEGGKLNDVIRGLVPDDLTQQLILQSLVSRRHPDSPVP-G----V--CIWKVCPPAPWRR---------- A_0855_017 MQTASWVMVMMMVWITAPLSEGGKLNDVIRGLVPDDVTPQLILRSLFFHRPSDSVVR STV-PVHICYWKVCPPSPWRR-PNGKG---- V_CG13_168 MQTAYWVMVMMMVWITAPLSEGGKLNDVIRGLVPDDVTPQLILRSLISRRPSDSVVR STV---HICYWKVCPPPPWRR-PNGKG---- V_1302_037 MQTAYWVMVMMMVWITAPLSEGGKLNDVIRGLVPDDVTPQLILRSLISRRPSDSVVR STV---HICYWKVCPPPPWRR-PNGKG---- V_1258_017 MQTAYWVMVMMMVWITAPLSEGGKLNDVIRGLVPDDVTPQLILRSLISRRPSDSVVR STV---HICYWKVCPPPPWRR-PNGKG---- A_0885_158 MQTAYWVMVMMMVWITAPLSEGGKLNDVIRGLVPDDVTPQLILRSLFFHRPSDSVVR STV-RVHICYWKVCPPSPWRR-PNGKG---- A_0875_007 MQTAYWVMVMMMVWITAPLSEGGKLNDVIRGLVPDDVTPQLILRSLFFHRPSDSVVR STV-PVHICYWKVCPPSPWRR-PNGKG---- A_0875_008 MQTAYWVMVMMMVWITAPLSEGGKLNDVIRGLVPDDVTPQLILRSLIFHRPSDIVVR PTV---VMCPWKICPPSP------------- A_0055_157 MQTASWVMVMMMVWITAPLSEGGKLNDVIRGLVPDDVTPQLILRSLFFHRPSDSVVR STV-PVHICYWKVCPPSPWRR-PNGKG---- A_0039_027 MQTAYWVMVMMMVWITAPLSEGGKLNDVIRGLVPDDVTPQLILRSLFFHRPSDSVVR STV-RVHICYWKVCPPRPWRR-PNGKG---- A_0520_145 MQTASWVMVMMMVWITAPLSEGGKLNDVIRGLVPDDVTPQLILRSLFFHRPSDSVVR STV-PVHICYWKVCPPSPWRR-PNGKG---- A_0048_023 MQTASWVMVMMMVWITAPLSEGGKLNDVIRGLVPDDVTPQLILRSLFFHRPSDSVVR STV-PVHICYWKVCPPSPWRR-PNGKG---- A_0025_246 MQTASWVMVMMMVWITAPLSEGGKLNDVIRGLVPDDVTPQLILRSLFFHRPSDSVVR STV-PVHICYWKVCPPRPWRR-PNGKG---- A_0031_391 MQTACWVMVMMMVWITAPLSEGGKLNDVIRGLVPDDVTPQLILRSLFFHRPSDSVVR PTV-PVHICYWKVCPPRPWRR-PNGKG---- A_1387_017 MQTACWVMVMMMVWITAPLSEGGKLNDVIRGLVPDDVTPQLILRSLFFHRPSDSVVR PTV-PVRICYWKVCPPSP------------- A_0239_358 MQTACWVMVMMMVWITAPLSEGGKLNDVIRGLVPDDVTPQLILRSLFFHRP-DSVVR PTV-PVHICYWKVCPPRPWRR-PNGKG---- A_0239_360 MQTAYWVMVMMMVWITAPLSEGGKLNDVIRGLVPDDVTPQLILRSLFFHRP-DSVVR PTV-PVHICYWKVCPPRPWRR-PNGKG---- A_0025_247 MQTAYWVMVMMMVWITAPLSEGGKLNDVIQGLVPDDVTPQLILRSLIFHRPSDN-VR PTV----ICIWKICPPSP------------- betulinusAMP44598 MEMAYWVMVMMMVWITAPLSEGGKLNDVIRALAPDDVTPQFILRSLISRRRSDSDVR E----VPVCSWKICPP--------------- lividusATO88028 MQTAYWVMVMMMVWITAPLSEGGKLNDVIRGLVPDGLTPQLILQSLVSSHNP----S PT---ATICIWKVCPPDPWRRHDLQKSNK-- frigidusATO88031 MQTAYWMIVMMMVWITAPLSEGGKLNDVIRGLVPDDLTPQLILQSLDSRRHDHG-IR PK--RVDICNWRICAPNPLRRHDLKKRNN-- milesATO88034 MQTAHWMIVMMMVWITAPLSEGGKLNDVIRGLVPDDLTPQLILQSLDSRRHDHG-IR PK--RVDICNWRICAPNPLRRHDLKKRNN-- litteratusATO88032 MQTAYWVMVMMMVGITAPLSEGRKLNDAIRGLVPNDLTPQL-LQSLVSRRHRVFHLD NTYLKIPICAWKVCPPTPWRRRDLKKRNK-- magusQFQ60979 MQTAYWVMVMMMVWITAPLSEGGKLNDVIRGLVPHFLTPQHILQSLTSRNGSGSS-- NQK-EAQICIWKVCPPTPWR----------- [Con-ikot-ikot-2] [New Framework] [ /----------Signal------/----Pro-----/ /---CC------C--------------C-------C-------CC-----C---C-------C---C----C-] V_CG13_135 --MNMWMTISVCVVVVMAATVVGSTPLQEQGLGLDER QNPGCCPWEFYDCLIRHTV-WRNRLDICYSQASNICTRGRPGGCCPGFLRCFEECTSRDRAVCYYRCKF----- V_1302_088 --MNMWMTISVCVVVVMAATVVGSTPLQEQGLGLDER QNPGCCPWEFYDCLIRRTV-WRNHLDICYSQASNICTRGRPGGCCPGFLRCFEECTSRDRAVCYYRCKFVSCWF A_0520_187 --MNMWMMISMCVVVVMAAAVVGSTPLQEQGLSLDER RNPGCCPWEFYDCLIQRTV-WRSRLHTCYSQASMICTRGRVGGCCPGFLRCFEVCTSRDRAVCYYRCKFARC-- A_0048_122 --MNMWMMISMCVVVVMAAAVVGSTPLQEQGLSLDER RNPGCCPWEFYDCLIQRTV-WRSRLHTCYSQASMICTRGRVGGCCPGFLRCFEVCTSRDRAVCYYRCKFARC-- K_0010_082 --MNMWMMISMCVVVVMAAAVVGSTPLQEQGLSLDER RNPGCCPWEFYDCLIQRTV-WRSRLDTCYSQASMICTRGRVGGCCPGFLRCFEVCTSRDRAVCYYRCKFARC-- betulinusAMP44637 MAMNMWMTISVCVVVVMAATVVGSTPLQEQGLSLDER HNPGCCPWEFYDCLIQRMV-WRSRLTICYNQASMICSRGRPGGCCPGLLHCFEECTSRDSAVCYYRCKFAPC-- magusQFQ60982 MAMNMWMTISVCVVVVMATTVVGSTPLQERGLSLDER RAIGCCAWQVYDCLVQRGHYW----YICYSWASWICTRGLSDRCCPGLERCIRRCVSGYRNVCYYHCIFERC-- [Con-ikot-ikot-3] [New Framework] [ /----------Signal------/--Pro---/ /-C-------CC------C---C--------C---C-------C-C-----CC---------C----------C--------C] A_0039_146 MTMNMSMTLSVIVMVVIAATVLGSTPLE--DKD INCGGEEYHECCRYEMRNCVE--------------------------------------------------------------- A_0039_334 --------------------------------- -------------------------------CWDTCYYSAASNCECDPSYGCCPTFLEHYSSCLFFDGYGLSECWEQARYVPCW A_0520_004 MTMNMSMTLSVIVMVVIAATVLGSTPLE--DKD INCGGEEYHECCRYEMRDCMEECTSPSDADSCWDNCYYSAATNCGCDPSYGCCPAFLERYSSCLFFDGYGLSECWEQAKYVPC- A_0055_004 MTMNMSMTLSVIVMVVIAATVLGSTPLE--DKD INCGGEVYHECCRYEMRNCMEECTSVWDADSCWDICYYSAATNCECHPSYGCCPTFLERYSSCLFYDGYGLSECWEQAKYVPC- A_0855_121 MTMNMSMTLSVIVMVVIAATVLGSTPLE--DKD INCGGEVYHECCRYEMRNCMEECTSPSDADSCWDICYYSAATNCECHPSYGCCPTFLERYSSCLFHDGYGLSECWEQAKYVPC- V_CG13_167 MTMDMSMTLSVFVMVVIAATVLGSTPLQ--DKD INCGGEVYHECCRYEMRNCMEECTSVWDADSCWDICYYSAATNCECHPSDGCCPTFLERYSSCLFHDDYGLSECWEQAKYVPC- V_1302_175 MTMDMSMTLSVFVMVVIAATVLGSTPLQ--DKD INCGGEVYHECCRYEMRNCMEECTSVWDADSCWDICYYSAATNCECHPSDGCCPTFLERYSSCLFHDDYGLSECWEQAKYVPC- V_1258_152 MTMDMSMTLSVFVMVVIAATVLGSTPLQ--DKD INCGGEVYHECCRYEMRNCMEECTSVWDADSCWDICYYSAATNCECHPSDGCCPTFLERYSSCLFHDDYGLSECWEQAKYVPC- V_1302_174 MTMDMSMTLSVFVVVVIAATVLGSTPLQ--DKD INCGGEVYHECCRREMRNCMEEYASVSDADSNWDTCYSAAATNCQCHPSDGCCPTFLERYSSCLFHDDYGLSECWEQAKYVPC- A_1387_261 MTMNMSMTLSVIVVVVIAATVLGSTPLE--DKD INCGGEVYHECCRYEIRNCMEECTSVWDADSCWDICYYSAATNCECHPSYGCCPTFLERYSSCLFYDGYGLSECWEQAKYVPC- A_0239_409 MTMNMSMTLSVIVMVVIAATVLGSAPLE--DKD IDCGGEVYHECCRYEMRNCMEECTSVWDADSCWDICYYSAATNCECHPSYGCCPTFLERYSSCLFYDGYGLSECWEQAKYVPC- A_0031_377 MTMNMSMTLSVIVMVVIAATVLGSAPLE--DKD INCGGEVYHECCRYEMRNCMEECTSVWDADSCWDICYYSAATNCECHPSYGCCPTFLERYSSCLFYDGYGLSECWEQAKYVPC- A_0048_068 MTMNMSMTLSVIVMVVIAATVLGSTPLE--DKD INCGGEVYHECCRNEMRNCMEECTSPSDADSCWDNCYYSAATNCECDPSYGCCPAFLERYSSCLFFDGYGLSECWEQAKYVPC- V_1302_090 MTMNVSITLSAFVVVVMAATVVSSSSFQ--EKR YTCGDTQYHECCRQEMRRCLESCLINGDDDTCWHPCYAESAMNCGCVATDGCCPTFLDKMSSCLL-KGHTIETCWEQTKFVPC- K_0010_297 MTMNMSMTLSVFVMVVIAATVLGSTPLE--DKN INCRGRAYDECCRHRMRDCMEGLACVRKADSCWDNCYYLAATKCGCHPSNGCCNKFLERYSSCLFHHGYGLSKCWEWTKHVAC- betulinusAMP44638 MTMSMSVTLSVFVMVVVAAAVLGSTPLE--DKD LYCGRNAYNECCRHGMRNCMERCAT--DADSCWDHCYYTAATNCGCHPSNGCCAKFLERYSSCLFHHGNQLSECWKQTQDVPC- praecellensATF27580 MTMNMSMTLIAFAMVVMASSVIGSIPRQCKGKD FPCGSKRYHRCCKYAMRDCLKTCPRD-DTHKCWSPCYKTAAEKFGCRPGNGCCPTFLDRMSGCLMED-RPLKVCWRRTKSVPCR [Con-ikot-ikot-4] [New Framework] [ /--------Signal-------/-------Pro-------/ /CC------C-----C-------C---C-------C-------CC-----C---C--------------C---C-----C] A_0885_161 MTMNMRMTHIVFVMAVMATTLAGSPPSQEQELNRNDRDIQR -CCAKKADECLRDIGCLNSGDRYCAEPCYDTDTSSCG------------------------------------------- V_1302_166 MAMNMRMTHIVFVMAVMATTLTGSPPSQEQELNRNDRDIQR -CCAEKADECLRDIGCLNSGDRYCAEPCYDTDTSSCGLNADDNCCFNYKFCLAECLISLEDAPSDPLDICYEGCKEGEPC K_0010_003 MAMNVWMTISVFVVVVMATTVIGSTPSQEQE--RNDR-SSR QCCAIKSYQCLQLHECLTPIDSACAVQCKTTDTSSCGSPPSDNCCSTYKSCLVDCQISRGDQVEDPLRVCYNQCDQEHPC betulinusAMP44683 MAMNVWMTTSVFLVAVMATIVLGSTPLQEQK--RNDR-SSR KCCAVKSYLCLQGHGCLTPSDSSCAEQCKTTDTSTCGSNAGDNCCSTYKSCLVDCQISRGNQHGDPLLICYNHCSQQHPC [Con-ikot-ikot-5] [Formerly Cerm Superfamily 14 in Abalde et al. 2018 GBE 10:2643–2662] [Also a turritoxin] [New Framework] [ /----------Signal------/------------CC------C----C-------C---C--------C-------CC-----C---C----------C---C----C---] A_0855_011 --MNMRMTIIVFVVVATVATVVRSTPFPE--PWP-SCCIMNMIECVWHTCS-EDPLACTQNCYSQ-ATRLCGGNHHSGCCPGFVRCFEICSFEGPGEPSVCFEICKDVDCWE-- A_0855_012 --MNMRMTIIVFVVVATVATVVRSTPFPG--PRP-SCCIKNMIECIWYTCA-ENPLACTDNCHSL-ATSRCEGDRRSGCCPGFVTCFENCLFEEPGETFVCGVRCKDVDC---- A_0875_014 --MNMRMTIIVFVVVATVATVVRATPFPG--PRP-SCCIKNMIGCICYKCA-EDPLACTDSCHSL-ATTRCEGDRRSGCCPGFVTCFENCLFEEPRETSVCGVRCKDVDC---- A_0055_035 --MNMRMTIIVFVVVATVATVVRSTPFPE--PLP-SCCIVNMIECVWLKCS-KDPLACIQDCHSK-ATSRCGGNPHIGCCPGVEGCFESCLSEGPGEPFVCFEICHDVDCW--- A_0055_036 --MNMRMTIIVFVVVATVATVVRSTPFPD--TLP-SCCVRNMIECIWYTCS-EDPLACTQHCHSL-ATSRCEGDHHSGCCPGFVRCFKKCLFVEPGETSVCGERCKDVDC---- A_0039_019 --MNMRMTIIVFVVVATVATVVRSTPFPE--PLP-SCCIVNMIECVWFKCS-KDPLACIQDCHSK-ATSRCGGDPHIGCCPGFEGCFESCLSEGPGEPFVCFEICKDVDCW--- A_0239_277 --MNMRMTIIVFVVVATVATVVRSTPFPD--TLP-SCCVRNMIECIWYTCS-EDPLACTQHCHSL-ATSRCEGDHHSGCCPGFVRCFKKCLFVEPGETSVCGERCKDVDC---- A_1387_296 --MNMRMTIIVFVVVATVATVVRSTPFPD--PWP-SCCVRNMMECIWYTCS-EDPLACTQHCHSQ-ATSRCEGDHHSGCCPGFVRCFKNCLFEEPGETSVCGERCKDVDC---- A_0031_134 --MNMRMTIIVFVVVATVATVVRSTPFPD--PWP-SCCIRNMIECIWYTCA-EDPLACTQHCHSL-ATGRCEGDHHSGCCPGFVRCFHNCLFEKPGETSVCGERCKDVDC---- A_0520_188 --MNMRMTIIVFVVVATVATVVRSSPFPD--PRP-SCCIKNMIECIWYTCA-EDPLVCTDNCHSR-ATNRCEGDRRSGCCPSFVTCFENCLLEKPGETSVCGTRCKDVDC---- A_0048_123 --MNMRMTIIVFVVVATVATVVRSSPFPD--PRP-SCCIKNMIECIWYTCA-EDPLVCTDNCHSR-ATNRCEGDRRSGCCPSFVTCFENCLLEKPGETSVCGTRCKDVDC---- A_0520_186 --MNMRMTIIVFVVVATVAIVVRSTPFTD--SSP-SCCIKNTIECIVYTCP-ENILDCTQNCHSL-ATSRCEGDHHSGCCPAFGTCLENCLIEEPGQNAVCVARCKDVDC---- A_0025_333 --MNMRMTIIVFVVVATVATVVRSTSFQD--SSP-SCCIKNTIECIVYTCP-ENVLACTENCHSL-ATSLCEGDHHSGCCPAFVTCLENCLIEEPGKNSVCVARCKDVDC---- A_0031_135 --MNMRMTIIVFVVVATVATVVRSTPFPE--PLP-SCCIVNMIECVWFKCS-KDPLACIQDCHSK-ATSRCGGDPHIGCCPGFEGCFESCLSEGPGEPFVCFEICKDVDCW--- A_0239_276 --MNMRMTIIVFVVVATVATVVRSTPFPE--PLP-SCCIVNMIECVWLKCS-KDPLACIQDCHSK-ATSRCGGNPHIGCCPGVEGCFESCLSEGPGEPFVCFEICHDVDCW--- ermineusAXL95434 --MNMRMTIIVFVVVATAATVVGSTPLEERGSWPTSCCIRKTIECVRYKCL-LTPLLCTPFCYSKGATARCGGDPDEGCCPAFFGCYISCLRGVAGKPFACYKTCRDVDCEL-- tribbleiJAG92852 --MNMWMTISMFAVVATAATVVGSTPLEE--RQPRDCCHSIFYECAAEECSFTDDLLCAEMCW-DAATDVCGGDPDSGFCPSFFGCFKDCVFTESGPHFRCYELCKT-GAYAN- lenavatiJAI17876 ----MWMTISMFAVVVTAATVVGSTPLEE--RQPRDCCHSIFYECAAEECSFTDDPGCPEMCYLDAATDVCGGHPDSGCCPSFFDCFMDCVFIKSGPHFECYEFCKSVPCWLDK TurridrupaJAC94799 --MNMWMTISMFAVVATAATVVGSTPLEE--RQPRDCCHSIFYECAAEECSFTDDLLCAEMCW-DAATDVCGGHPDFGCCPSFFDCFMDCVFVESGPHFRCYELCKTVPCWLDK [Con-ikot-ikot-6] [New Framework] [ /-------Signal---------/------Pro-----/ /----CC-----C---C--------C---C-------C--------C-----C---C--------C---C-------C-------CC-----C---C--------C--------C] A_0048_334 MAMNMRMTLSVLVVAVLTTTVVRSTALHEDKREALQRRG DTTAMCCFTLFGCYQECEANG-GEYCWENCANDYENECYG-DHSFYCWSFGSCYAKCIKEKSEDHCFQG---------------------------------------------- A_0885_287 MAMNMRMTLSVLVVVVLTTTVVRSTALHEDKREALQRRG DTTAMCCFTLFGCYQECEANG-GEYCWENCANDYENECYG-DHSFYCWAFGSCYAKCIKEKSEDHCFQGCSYEAKLECIE----------------------------------- A_0031_050 MAMNMRMTLSVLVVAVLTTTVVHSTALHEDKREALQRRG DTTAMCCFSLFGCYQECEANG-GEYCWENCANDYENECYG-DHSFYCWSFGSCYAKCIKEKSEDHCFQGCSYEAKLECIEEGSIGCCPNFMMCYYECRKTNDQFSCSNQCEKVRC tribbleiJAI17976 MAMNMWMTLSVLVVVVFTTTVVCSTSLDEDKREALQLRW DTASLCCLSIYGCYWECKTKG-GDNCWLWCAQENYDVCNG-MYGDYCWPFANCFKECIKTKSKEHCFNGCTYEAKLKCIEEGYVACCPKFMTCYNECLENTGQYSCSNQCEGVGC [Conkunitzin-1] [New Framework] [ /--------Signal-------/--C--------C---------------C-------C------------C---C--------C--------C---------------C-------C------------C---C---C--------C---------------C-------C------------C---C--] /-------------------KU--motif-----------------------/ /------------------KU--motif------------------------/ /-------------------KU--motif----------------------/ V_1278_104 -----------------------------------RAAINQFYYNWNARQCQAFIYGGCGGNDNRFETREECERACTIPSRDSDCNLPKETGLCRALIPSFFYDLNTGECQPFNYGGCGGNANRF------------------------------------------------------------------- A_0039_196 MTCFRSAVYPLLLMATVIVVATGNRCRLEPDTGMCRAAISQFYYNWNARQCQAFIYGGCGGNDNRFETREECERACTIPSRDSDCNLPKETGLCRARIPSFFYDLNTGECQPFNYGGCGGNANRFDTLAECKHKCHVVCQEPKEIGFCRAAFRRWFYNRNRKMCERFIYGGCGGNRNNFQSLSECQGQCMSN A_0055_061 MTCFRSAVYPLLLMATVIVVATGNRCRLEPDTGMCRAAISQFYYNWNARQCQAFIYGGCGGNDNRFETREECERACTIPSRDSDCNLPKETGLCRARIPSFFYDLNTGECQPFNYGGCGGNANRFDTLAECKHKCHVVCQEPKEIGFCRAAFRRWFYNRNRKMCERFIYGGCGGNRNNFQSLSECQGQCMSN V_CG13_197 -----------------------------------------------------------------------------------DCNLPKETGLCRALIPSFFYDLNTGECQPFNYGGCGGNANRFDTLAECKHRCHVVCQEPKEVGFCRAAFRRWFYNRNRKMCERFIYGGCGGNRNNFQSLSECQGQCMSN V_1302_002 MTCFRSAVY-------------------------------QFYYNWNARQCQAFIYGGCGGNDNRFETREECERACTIPSRDSDCNLPKETGLCRALIPSFFYDLNTGECQPFNYGGGGGNANRFDTLAECKHRCHVVCQEPKEVGFCRAAFRRWFYNRNRKMCERFIYGGCGGNRNNFQSLSECQGQCMSN K_0010_298 --CFRSAVYPLLLTATVIVVATGNRCRLEPDTGLCRAAINQFYYNWNARQCQAFIYGGCGGNDNRFKTREECERACTLRSRNSDCNLPKETGPCRALMPSFFYDLDTGKCEPFNYGGCRGNANRFDTLEECERRCAVVCQEPKLVGHCRAAFRHWFYNRKTRMCERFIYGGCGGNRNNFQSFWECRDKCMPN ermineusAXL95354 MTCFRSAVYPLLLTATVIVVATGNRCRLEPDAGLCRAAIDQFYYNWNERQCQTFIYGGCGGNDNRFGTREECEQACTVPSRNRDCNWPKETGPCRARFPSFFYDLNTGKCQDFIYGGCGGNANRFDTLDDCEQRCAVVCQEPKQVGLCRAAFRRWFYNRNSMMCERFIYGGCGGNRNNFQTFSECRDQCMLK ermineusAXL95411 MTCFRSAVYPLLLTATVIVVATGNRCRLEPDAGLCRAAIDQFYYNWNERQCQTFIYGGCGGNDNRFGTREECEQACTVPSRNRNCNWPKETGPCRARFPSFFYDLNTGKCQDFIYGGCGGNANRFDTLDDCEQRCAVVCQEPQQVGLCRAAFRRWFYNRNSMMCERFIYGGCGGNRNNFQTFSECRDQCMLK magusDAC80551.1 MTCFRCAVYPLMLTAMVVVVATGNRCRLARDTGLCRAFMPRFYYNWNEQECQAFIYGGCGGNANRFQTLEECQRACRAPFRKSDCKLPKETGPCRALMPSYYYDLSTETCEPFIYGGCGGNANRFDTFAECKQRCAGICQEPKEVGLCRAAIPRWFYNRNTERCEQFIYGGCGGNRNNFQSLLECRDQCVLN [Conkunitzin-2] [New Framework] [ /---------Signal--------/--C--------C---------------C-------C------------C---C-------C--------C---------------C-------C------------C---C------] /-----------------KU--motif------------------------/ /----------------------KU--motif------------------/ A_0855_009 MDALRSAAVLLLVILFTQLATLRAEDPCLQPRVAGRCKLRYHRFFFNSSSGTCEPFIYGHCEANANNFETLEACQLAC----YNRCQQPKQPGPCQQQFSKFFFNSQTGACEEFIYGGCDGNRNNFDTLEDCQATCLTIPPQP A_0875_067 MDALRSAAVLLLVILFTQLATLRAEDPCLQPRVAGRCKLRYHRFFFNSSSGTCEPFIYGHCEANANNFETLEACQLAC----YNRCQQPKQPGPCQQQFSKFFFNSQTGACEEFIYGGCDGNRNNFDTLEDCQATCLTIPPQP A_0885_148 MDALRSAAVLLLVILFTQLATPRAEDPCLQPRVAGRCKLRYHRFFFNSSSGTCEPFIYGHCEANANNFETLEACQLAC----YNRCQQPKQPGPCQQQFSKFFFNSQTGACEEFIYGGCDGNRNNFDTLEDCQATCLTIPPQP A_0039_091 MDALRSAAVLLLVILFTQLATLRAEDPCLQPRVAGRCKLRYHRFFFNSSSGTCEAFIFGHCEANANNFKTLEACQLAC----YNRCQQPKQPGPCQQQFSKFFFNSQTGACEEFIYGGCDGNRNNFDTLEDCQATCLTIPPQP A_0055_167 MDALRSAAVLLLVILFTQLATLRAEDPCLQPRVAGRCKLRYHRFFFNSSSGTCEAFIFGHCEANANNFKTLEACQLAC----YNRCQQPKQPGPCQQQFSKFFFNSQTGACEEFIYGGCDGNRNNFDTLEDCQATCLTIPPQP V_1258_163 --------------------------------------------------------------------------------------------GPCQQQFPKFFFNSQTGACEEFIYGGCDGNRNNFDTLEDCQATCLTIPPQP V_1278_024 MDALRSAAVLLLVILFTQLATLRAEDPCLQPRVAGRCKWRNERFFFNSSSGTCEPFIYGDCEANANNFETLEACQLTC----YNRCQQPKRPGPCQQQFPKFFFNSQTGACEEFIYGGCDGNRNNFDTLEDCQATCLTIPPQP V_CG13_025 MDALRSAAVLLLVILFTQLATLRAEDPCLQPRVAGRCKWKNERFFFNSSSGTCEPFIYGDCEANANNFETLEACQLTC----YNRCQQPKRPGPCQQQFPKFFFNSQTGACEEFIYGGCDGNRNNFDTLEDCQATCLTIPPQP A_0025_195 MDALRSAAVLLLVILFTQLATLRAEDPCLQPRVAGRCKLRYHRFFFNSSSGTCEAFIFGHCEANANNFKTLEACQLAC----YNRCQQPKQPGPCQQQFSKFFFNSQTGACEEFIYGGCDGNRNNFDTLEDCQATCLTIPPQP A_0520_231 MDALRSAAVLLLVILFTQLATLRAEDPCLQPRVAGRCKLRHHRFFFNSSSGTCEAFIFGHCEANANNFKTLEACQLAC----YNQCQQPKQPGPCQQQFSKFFFNSQTGACEEFIYGGCDGNRNNFDTLEDCQATCLTIPPQP A_0031_199 MDALRSAAVLLLVTLFTQLATLRAEDPCLQPRVAGRCKLRYRRFFFNSSSGTCEPFIYGLCEANANNFETLEACQLAC----YNQCQQPKQPGPCQQQFSKFFFNSQTGACEEFIYGGCDGNRNNFDTLEDCQATCLTIPPQP A_0048_176 MDALRSAAVLLLVILFTQLATLRAEDPCLQPRVAGRCKLRYHRFFFNSSSGTCEAFIFGRCEANANNFKTLEACQLAC----YNQCQQPKQPGPCQQQFSKFFFNSQTGDCEEFIYGGCDGNRNNFDTLEDC----------- K_0010_428 MDVLRSAAVLLLVTLFTQLATLRADDPCLLPRVVGRCTGTNERFFFNSSSGTCEPFIYGGCDANANNFKTLKACQFVC----YNQCQQPKEPGRCQFQFPKFFFNPQTGACEEFIYGGCDGNRNNFDTLKDCQATCLAITPQP ermineusAXL95675 --------------------------------VIGRCPESYERFFFNPSSGTCEPFNYGGCDGNANNFETFEACKAVC----HNRCQQPKQPGSCQYQFSKFFFNSQTGACEEFIYGGCNGNRNNFDTLKDCQKICQAT-PQP V_CG13_044 MEGLRLAAVLLVVTL-----CVRAEDRCQQPKAPGRCMAYMERYYFNSEKGACEQFTYGGCEGNENNFETLEACQSACPTVAEDPCQLPKVVGRCKAKLDRFYFNALTGTCQPFVYGGCDGNANNFETFQACQAACL------ V_CG13_045 MEGLRLAAVLLLVTL-----CVRAEDRCQQPKAPGICKVYMKRYYFNSEKGACEQFFYGGCGGNENNFKTLKACQSACPT--EDPCQLPKVVGRCRAKFDRFYFNTLTRTCQPFVYGGCDGNANNFQTFQACLSACL------ A_0039_004 MEGLRLAAVLLVVTL-----CVRAEDPCQLPKVVGKCKAKFDRFYFNTLTRTCQHFVYRGCDGNANNFQTVEACLSTCP---------------------------------------------------------------- A_0520_024 -------------------------------------------------------------------------------------CQLPKVVGKCKAKFDRFYFNTLTRTCQHFVYGGCDGNANNFHTFGACLSTCP------ A_0048_338 -------------------------------------------------------------------------------------CQLPKVVGKCKAKFDRFYFNTPTRTCQHFVYGGCDGNANNFQTFEACLSTCL------ [Conkunitzin-3] [Framework IX] [ /--------Signal------/---------------------------------------------------------------------------C--------C---------------C-------C------------C---C---------] /-------------------KU--motif-----------------------/ A_0875_003 MEGRHLAVVLIVTSCLSALTVGDT--RSVP-----------------------------------------------------------------DVCLQPVAVGLCKGKFSRYYFDADSGMCRLFYYGGCNGNGNRFLSVGACQTTCGHPWKGNPSF A_0855_018 MEGRHLAVVLTVTSCLSALTVGDT--RSVP-----------------------------------------------------------------DVCLQPVAVGLCKGKFSRYYFDADSGMCRLFYYGGCNGNGNRFLSVGACQTTCGHP------- A_0855_019 MEGRHLAVVLTVTSCLSALTVGDT--RSVP-----------------------------------------------------------------DVCLQPVAVGLCKGKFSRYYFDADSGMCRLFYYGGCFGNENRFGNMDACLNTCEYPWKRITGY A_0039_145 MEGRHLAVVLIVTSCLSALTVGDT--RSVP-----------------------------------------------------------------DVCLQPVAVGSCKGKFPRYYFDADSGMCRLFYYGGCSGNENRFGNMDACLNTCEHPWKGNPSF A_0520_057 MEGRHLAVVLIVTSCLSALTVGDT--RSVP-----------------------------------------------------------------DVCLQPVAVGLCKGKFPRYYFDADSGMCRLFYYGGCFGNENRFGNMGACLNTCEHPWKGNPRF A_0048_058 -EGRHLAVVLIVTSCLSALTVGDT--RSVP-----------------------------------------------------------------DVCLQPVAVGSCKGKFPRYYFDADSGMCRLFYYGGCFGNENRFGNMGACLNTCEHPWKGNPSF A_0025_020 MEGRHLAVVLIVTSCLSALTVGDT--RSVP-----------------------------------------------------------------DVCLQPMVVGPCRGRLPHYYFSPALGMCRLFHYGGCYGNGNRFGNMDACLNTCEYPWKGIPGY A_0885_001 MEGRHLAVVLIVTSCLSALTVGDT--RSVP-----------------------------------------------------------------DVCFQPMVAGPCRGRLPRYYFSPALGMCRLFHYGGCYGNGNRFGNMDACLNTCEYPWKGIPDF A_0055_056 MEERHLAV-LIVTSCLSALTVGDT--RSVP-----------------------------------------------------------------DVCLQPVVVGPCRGRFPRFYFNPVSGMCQLFHYGGCVGNGNRFRNMDACLKTCGYPWKGIPDF A_0039_144 MEGRHLAVVLIVTSCLSALTVGDT--RSVP-----------------------------------------------------------------DVCLQPVAVGSCKGKFPRYYFDADSGMCRLFYYGGCFGNGNRFRSVGACLKTCRYPWKGIPSF A_1387_135 MEGRHLAVVLTVTSCLSALTVGDT--RSVP-----------------------------------------------------------------DVCLQPVAVGPCKGKFPRYYSDADSGMCRLFYYGGCYGNGNRFRSVGACLKTCGYPWKGIPDF A_1387_136 -----------------------------------------------------------------------------------------------DVCLQPVAVGPCKGKFPRYYSDADSGMCRLFYYGGCYGNGNRFRSVGACLKTCRYPWKGIPDF A_0031_105 MEGRHLAVVLIVTSCLSALTVGDT--RSVP-----------------------------------------------------------------EVCLQPVAVGLCKGKFPRYYFDADSGMCRLFYYGGCFGNGNRFRSVGACLKTCRYPWKGIPSF A_0031_106 MEGRHLAVVLIVTSCLSALTVGDT--RSVP-----------------------------------------------------------------EVCLQPVAVGLCKGKFPRYYFDADSGMCRLFYYGGCFGNGNRFRNMDACLKTCEYPWKGIPGY A_0031_107 MEGRHLAVVLIVTSCLSALTVGDT--RSVP-----------------------------------------------------------------DVCLQPVVVGPCRGRFPRFYFNPVSGMCQLFHYGGCVGNGNRFRNMDACLKTCEYPWKGIPGY A_0055_057 MEERHLAV-LIVTSCLSALTVGDT--RSVP-----------------------------------------------------------------DVCLQPVVVGPCRGRFPRFYFNPVSGMCQLFHYGGCVGNGNRFRNMDACLKTCEYPWKGIPGY A_0239_146 MEGRHLAVVLIVTSCLSALTVGDT--RSVP-----------------------------------------------------------------DVCLQPVVVGPCRGRFPRFYFNPVSGMCQLFHYGGCVGNGNRFRNMDACLKTCEYPWKGIPGY buxeusAMB57284 MEGRRLAVVLIVTSCLSALTVGDT--RSIP-----------------------------------------------------------------DVCLQPVVVGPCRGKFPHYYFNSVLGTCQLFDYGGCRGNENRFKKMDACLKTCEYPWRGILGY betulinusAMP44641 MEGRRLAVVLIVTSCLSALTVGDT--RSVP-----------------------------------------------------------------DVCFQPVVVGPCRGKFPHYYFNSILATCQLFDYGGCRGNENRFEKMDACLYTCEYPWRGILGY ermineusAXL95497 MEGRRLAVVLIVTSCLSALTVGDT-VPGLSALTVDDDTVP-------------------------------------------------------DVCRQPLEVGPCKAAYPRYYYNHASDTCQLFYYGGCNGNENRFEDFSGCLFTCIYPWMAALGY ermineusAXL95589 MEGRRLAVVLIVTSCLSALTVGDT-VPGLSALTVDDDTVP-------------------------------------------------------DVCRQPLEVGPCKAAYPRYYYNHALNTCQLFSYGGCNGNENRFEDFSGCLFTCIYPWMAELGY geographusBAO65571 MEGRRLAVVLIVTSCLSALTVGDT--RSVP-----------------------------------------------------------------DVCLQPMDVGPCERQLPRYYFNAVQVTCKRFDYGGCGGNQNRFNSKDDCLKKCLY----SLT- magusQFQ60983 ------AVVLIVTSCLSALTVGDT--RSAYAA---------------------------------------------------------------WQCFLPKEVGLCKGKFPRYYFDSALRICRRFIYGGCGGNGNRFLTQDACLNTCIYPLTGNQGY /-----------------KU--motif-----------------------/ /----------------------KU--motif-------------------/ V_CG13_203 MEGRRLAAVLILTICLLALEAGASRRRGLPANGCSPFVAQRKCYLRKDAGPCYASTRKYYFNRYSRTCEPFTYGGCQ--------------------------------------------------------------------------------- V_1278_029 MEGRRLAAVLILTICLLALEAGASRRRGLPANGCSPFVALRKCYLRKDPGPCYASTRKYYFNRYSRTCEPFTYGGCQGNDNRFDTKEDCLGCCLQSVCRQPVEPGPCKVYVEKYYFNMTSYDCERFIYGGCQGNGNNFGTYKECFGRCGPE------- K_0010_123 MEGRRFAAVLILTICLLELGAGASRRQGLPADQCSRSDALRKCYLPKDPGSCYASEDKYYFNRHVNTCETFIYGGCQGNDNRFDTMEDCLGCCLLSVCRQPVQPGSCKGHFERYYFNMTSNDCEKFTYGLCGTNDNNFPTYNECFGRCGPELLR---- V_1258_148 MEGRRLAAVLILTICLLALEAGASRRRGPP-----------------------------------------------------------------SVCKLPVEPGPCKARVEKYYFNMTSYDCEGFIYGGCQGNGNNFGTYNECFGRCGPE------- A_0885_123 MEGRRLAAVLILTICLLALRAGASRRWSLL-----------------------------------------------------------------SVCRQPVQPGPCQANMPRYYFNMASYDCEVFFYGGCGGNDNKFDTYNECYGRCGPE------- A_0875_081 MEERRLAAVLILTVCLLALGAGASRRRGLL-----------------------------------------------------------------SVCRQPVQPGPCQANIPRYYFNMASNDCEVFVYGGCQGNDNKFNTYNECYGRCGPE------- A_0039_084 MEERRLAAVLILTVCLLALGAGASRRQGLL-----------------------------------------------------------------SVCRQPVQPGPCKANMPRYYFNMASYDCEVFVYGGCQGNDNKFNTYNECYGRCGPE------- A_0855_239 MEGRRLAAVLILTICLLALEAGAVRRQGLL-----------------------------------------------------------------SVCRQPAELGPCKGFLPRYYFDTASYNCKEFIYGGCGSNGNNFVTKNECYRRCGPE------- A_0055_044 MEGRRLAAVLILTICLLAPRAGASRRWSLP-----------------------------------------------------------------SVCRQPMQPGPCKAYIRRYYFNMASYDCEMFGYGGCHGNGNNFGTYNECYGRCGLE------- A_0055_043 ------AAVLILTICLLALGAGASKCQGLQ-----------------------------------------------------------------SVCTQPVEPGPCKGNFDKYYFNMTSYDCERFIYGGCQGNCNNFGTYNECYGRCGLE------- A_0039_085 ------AAVLILTICLLALGAGASKCQGLQ-----------------------------------------------------------------SVCTQPVEPGPCKGNFDKYYFNMTSYDCERFIYGGCQGNCNNFGTYN---------------- V_1302_163 MEARRLAAVLILTICLLALEAGASRRRGLR-----------------------------------------------------------------SVCILPAEPGPCKAYIRRYYFDTAFYDCKPFIFGGCDNNGNNFQTYDECYSRCGPE------- V_1258_150 MEGRRLAAVLILTICLLALEAGASRRRGLR-----------------------------------------------------------------SVCILPAEPGPCKAYIRRYYFDTAFYDCKPFIFGGCDNNGNNFQTYDECYSRCGPE------- V_CG13_046 -----------------------------------------------------------------------------------------------AVCRLQAEVGPCKALQPRFYFHWDSKVCELFYYGGCRGNGNNFNTLEDCYDTCGP-------- V_1258_149 -----------------------------------------------------------------------------------------------------------KALQRRFYFHWDSKECELFYYGGCRGNGNNFNTLEDCYDTCGP-------- V_1302_164 MEGRRFAAVLILSICLLALGAGAVR----P-----------------------------------------------------------------AVCRLQAVVGPCKALQRRFYFHWDSKVCTLFFYGGCLGNGNNFNTSEDCYDTCGP-------- K_0010_121 MEGRRFAAVLILTICLLELGAGASKYGGLL----------SVCRQPAEPGMCKAYFEKYYFDMASNDCKKFIYGGCGSNGNNFHTYNECYGRCLLSVCRQPAEPGMCMAYFERYYFDMASDDCKKFIYGGCGGNENNFGTYNECYGRCGPVNRR---- A_0520_235 ----------------------------LL-----------------------------------------------------------------SVCRQPAEPGMCKAYFEKYYFDMASNDCKKFIYGGCGSNGNNFHTYNECYGRCGPVNRR---- A_1387_252 MEERRLAAVLILTVCLLALGAGASRRRGLQ-----------------------------------------------------------------SVCRQPVEPGPCKANMPRYYFNMASYDCEMFVYGGCGGNDNKFDTYNECYGRCGPE------- A_0520_237 MEGRRLAAVLILTICLLALGAGASRRRGQS-----------------------------------------------------------------NVCQLPAKPGPCKAYMLRYYFNAASHECKEFIYGGCGSNGNNFGTYTECYTSCWPVFMP---- A_0520_234 MEGRRLAAVLILTICLLALGAGAR-----P-----------------------------------------------------------------SRCSLPVKKGPCKGYMPRFYFDFDSEECKSFIYGGCGGNDNKFNTSKDCNDTCGKE------- A_0520_236 MEGRRLAAVLILTICLLALGAGAR-----P-----------------------------------------------------------------SRCSLPVETGPCKGYMPRFYFDCDSAECKPFIYGGCGGNNNKFNTFKDCCDTCG--------- A_0048_081 MEGRRLAAVLILTICLLALGAGAR-----P-----------------------------------------------------------------SRCSLPVETGPCKGYMPRFYFDCDSAECKPFIYGGCGGNNNKFNTFKDCCDTCG--------- A_0239_044 MEGRRFAAVLILSICLLALEADAVR----P-----------------------------------------------------------------AVCSLQAVKGPCKARLQRFYFDCDSEECKPFFFGGCGSNDNNFNTSEDCYDTCG--------- betulinusAMP44640 MEGRRFAAVLILAICLLAPGAAASRRHVLL-----------------------------------------------------------------NVCILPAITGPCKASMQRYYFDVTSYNCKTFIYGGCLGNGNNFHTYDECFDKCGLVIGR---- geographusBAO65570 MEGRRVAAVLIVTICMLALEAGALRD---P-----------------------------------------------------------------PLCNLLPDMGPCLAHMERFYFDRFSKECKVFIYGGCPGNANNFPTAKECYKRCGNK------- geographusBAO65571 MEGRRLAVVLIVTSCLSALTVGDTRS--VP-----------------------------------------------------------------DVCLQPMDVGPCERQLPRYYFNAVQVTCKRFDYGGCGGNQNRFNSKDDCLKKCLYSLT----- [Conkunitzin-4] [Framework IX] [ /-------Signal--------/------------------Pro---------------------/-----------------------C--------C---------------C-------C------------C---C-] /-------------------KU--motif-----------------------/ A_0039_197 -----------------------MPSVRWLLAVTTVAVVVIVMALSDPFSGSRTRHQATV-QMTRNAGYHEGAATKLQTGGTSSGTVDRCHLPPETGMCRAYIPMHFYNATLGRCQGFIYGGCNGNDNKFNTAEDCMRACHH A_1387_137 -----------------------MPSVRWLLAVTTVAVVVIVMALSDPFSGSRTRHQATV-QMTRNAGYHEGAATKLQTGGTSSGTVDRCHLPPETGMCRAYIPMHFYNATLGRCQGFIYGGCNGNDNKFNTAEDCMRACHH A_0025_001 -----------------------MPSVRWLLAVTTVAVVVIVMALSDPFSGSRTRHQATV-QMTRNAGYHEGAATKLQTGGTSSGTVDRCHLPPETGMCRAYIPMHFYNATLGRCQGFIYGGCNGNDNKFNTAEDCMRACHH A_0048_329 -------------------------SVRWLLAVTTVDVVVIVMALSDPFSGSRTRHQATV-QMTRNAGYHEGAATKLQTGGTSSGTVDRCHLPPETGMCRAYIPMHFYNTTLGRCQGFIYGGCNGNDNKF------------ V_CG13_146 MVISSSFKRVLKSLVRCCLQGGGMPSVRWLLAVTTVAVVVIVMALSDPFSGSRTRHQATA-QMTRDAGYHEGAATKLQTGGISSGTVDRCHLPPETGMCRAYIPMHFYNATLGRCQGFIYGGCNGNDNKFNTTEYCMRACHH A_0885_040 MVISSSFKRVLKSLVRCCLQGGGMPSVRWLLAVTTVAVVVIVMALSDPFSGSRTRHQATV-QMTRNAGYHEGAATKLQTGGTSSGTVDRCHLPPETGMCRAYIPMHFYNTTLGRCQGFIYGGCNGNDNKFNTAEDCMRACHH A_0055_003 MVISSSFKRVLKSLVRCCLQGGGMPSVRWLLAVTTVAVVVIVMALSDPFSGSRTRHQATV-QMTRNAGYHEGAATKLQTGGTSSGTVDRCHLPPETGMCRAYIPMHFYNATLGRCQGFIYGGCNGNDNKFNTAEDCMRACHH K_0010_452 -----------------------MPSVRWLLPLTTVAVVVSVMAFSGPYSGSRTRHQATV-QMTRSAGYHEGAATKLQTGGTSSGTVDRCHLPPETGMCRAYIPMHFYNATLG----------------------------- betulinusAMP44699 -----------------------MPSVRWLLAVTTVAVVVIVMALSGPYSGSRAHHQATV-QMTRNADYHKGAATKLQTDGTSSGTVDRCHLPPETGMCRAYMPMHFYNATLGRCQGFIYGGCNGNDNKFDTEEDCMKACHH magusQFQ60989 MVTLSSFKRVLKSLVRCCVQGGGMPSVRWLLAVTTVAVVVIMMALSGPYSGSRSPQQATV-QMTRNAGYHDRAATKLQTGGTSSGTVDRCRLPPETGMCRAYIPMHFYNATLGRCQGFIYGGCNGNDNKFNTAEECMKACHH ermineusAXL95564 MVTLSSFKRLLKSLVRCCLQGGGMPSVRWLWAVTAVAVVVIVMALCGPYSGSRTHHQATVHQMTRNAGYHEGVATKLQTGGTSSGAVDRCHLPPETGMCRAYIPMHFYNATLGRCQGFIYGGCNGNDN-------------- [Conkunitzin-5] [Framework VIII] [ /-------Signal---------/Pr/--------------------/----C----C--------C---------------C-------C------------C---C-/Pt] /-------------------KU--motif----------------------/ A_0855_258 -------------------------------------------ERRHRHNNVCVPIRCLFQARRGRCLNFDRRYHFNTLTMRCTRVHTGACYGRNNRFSSIENCELTCAPRR V_1302_008 MATFNIVLAALFASVILVDFAVQARRCHPPCEYGERCVSANRRERRHRHNNVCVPIRCLFQARRGRCLNFDRRYHFNTLTMSCTRVHTGACYGRNNRFSSIENCELTCAPRR V_1258_154 MATFNIVLAALFASVILVDFAVQARRCHPPCEYGERCVSANRRERRHRHNNVCVPIRCLFQARRGRCLNFDRRYHFNTLTMSCTRVHTGACYGRNNRFSSIENCELTCAPRR A_0055_216 MATFNIVLAALFASVILADFAVQARRCHPPCEYGERCVSANRQERRHRHNNVCVPIRCLFQARRGRCLNFDRRYHFNTLTMSC----------------------------- A_0875_134 MATFNIVLAALFASVILVDFAVQARRCHPPCEYGERCVSANRQERRHRHNNVCVPIRCLFQARRGRCLNFDRRYHFNTLTMRCTRVHTGACYGRNNRFSSIENCELTCAPRR A_0885_155 MATYNIVLAALFASVILVDFAVQARRCHPPCEYGERCVSANRQERRHRHNNVCVPIRCLFQARRGRCLNFDRRYHFNTLTMSCTRVHTGACYGRNNRFSSIENCELTCAPRR ermineusAXL95582 MATFNIVLAALFASVILVDFAVQARRCHPPCEYGERCVSANRRERRHRHNNVCVPVRCLFQARRGRCLNFDRRYHFNTLTMSCTRVHTGACYGRNNRFSSSENCELTCAPRR magusQFQ60990 MATFNIVLAALFASVILVDFAVQARRCHPPCEYGERCVSANRRERRHRHNNVCVPVRCLFQARRGRCLNFDRRYHFNTLTMSCTRVHTGACYGRNNRFSSSENCELTCAPRR [Conkunitzin-8] [Framework IX] [ /-------Signal-------/--------Pro---------/-------C--------C---------------C-------C------------C---C] /-------------------KU--motif---------------------/ A_0885_010 MPSCHARPQFTLPLVLFQELSSGKDTHQQSAHRKTDTLPDTSRVEGLPSLCSLPKVVGPCRASIPRFYFNSTQLECLPFTYGGCDGNDNNFETNSDCQASCR V_1258_009 MPSCHARPQFTLPLVLFQELSSEKDTHQQSAHRKTDTLPDTSRVEGLPSLCSLPKVVGPCRASIPRFYFNSTQLECLPFTYGGCHGNDNNFETYSDCQASCR V_1302_214 -----------------------------------DTLPDTSRVEGLPSLCSLPKVVGPCRASIPRFYFNSTQLECLPFTYGGCHGNDNNFETYSDCQASC- V_1278_101 --------------------------------------PDTSRVEGLPSLCSLPKVVGPCRASIPRFYFNSTQLECLPFTYGGCHGNDNNFETYSDCQASCR A_0031_170 MPSCHARPQFTLPLVLFQELSSGKDTHQQSAHRKTDTLPDTSRVEGLPSLCSLPKVVGPCRASIPRFYFNSTQLECLPFTYGGCDGNDNNFETNSDCQASCR betulinusAMP44698 MPSCHARPQFTLPLVLFQELSSDEDTRQQSAHRKTDSLPDTSRVEGLPSLCSLPKVVGPCRALIPRFYFNSTQLECLPFAYGGCHGNDNNFETYSECQASCR magusQFQ60993 MPSCHARPQFTLPLVLFQELSSDKDTHQQSAHRKTDTLPDTSRVEGLPSLCSLPKVVGPCRALIPRFYFDSTQLECLPFSYGGCDGNDNNFETYSECQASCR [Conkunitzin-9] [New Framework] [ /-------Signal------/Pro-/C----------C---------------C-------C------------C--CC-----C-----] /----------------------KU--motif-----------------------/ A_0885_323 MDARRVAAVLLVFSMARCVTAKQDPRCSEALAFG--DCDRRSTRWYYDQDNDECRSFMFTGCGGNGNNFYTEDKCKQWCMWNMACLSG-P A_0855_143 MDARRVAAVLLVFSMARCVTAKQDPRCSEALAFG--DCDRRSTRWYYDQDNDECRSFIFTGCGGNGNNFYTEDKCKQCCMWNMACPSG-P A_0875_122 MDARRVAAVLLVFSMARCVTAKQDPRCSEALAIG--DCDRRRTRWYYDQENDECRSFMFSGCRGNGNNFYTEDKCKRCCMW--------- A_0039_113 ----RVAAVLLVFSMARCVTAKQDPRCSEALAFG--DCDRGRIRWYYDQENDECRSFMFSGCRGNGNNFYTEDKCKRCCMWDMVCHSG-P A_0055_058 MDARRVAAVLLVFSMARCVTAKQDPRCSEALAIG--DCYRRRTRWYYDQENEECRSFMYSGCRGNGNNFYTEDKCKGCCMWDLVCLSG-P V_CG13_047 MDARRVAAVLLVLSMACCVTAKQDPRCSEALAFG--NCDRRSTRWYYDQENEECRSFVFTGCGDNGNNFYTEDKCKTCCVWDRVCHSG-P V_1302_124 MDARRVAAVLLVLSMACCVTAKQDPRCSEALAFG--DCDRRRIRWYYDQENEECRNFVFTGCGGNGNNFYTEDKCKACCMWDMVCQSG-P V_1258_053 MDARRVAAVLLVLSMACCVTAKQDPRCSEALAFG--DCDRRRIRWYYDQENEECRNFVFTGCGGNGNNFYTEDKCKACCMWDMVCQSG-P A_0039_112 ----RVAAVLLVFSMARCVTAKQDPRCSEALALG--DCDDISARWYYDQDNDECRSFIFTGCGGNGNNFYTKDKCKQCCMWDMVCWPD-L A_0025_346 MDARRVAAVLLVLSMARCVTAKQDPRCSEALAVG--DCNRRRARWYYDQENEECRRFMFNGCGGNGNNFGTVEKCKECCMWDRVCQSG-P A_1387_230 MDARRVAAVLLVLSMARCVTA-ADPRCLQPLNSG--SCSRMRERWYYDQQHQECRTFQYTGCGGNDNNFYTVGQCKECCLWDMVCRSD-P A_0031_111 ----RVAAVLLVLSMARCVTA-ADPRCLQPSIFG--SCSQRRERWYYDQQHDECRTFQYSGCGGNDNNFYTEDKCKKCCMWDMVCLSG-P A_0520_032 MDARRVAAVLLVLSVARSVTA-TDARCSEPLDMGHPGCSRVRIRWYYNQVEEMCLPFQYTGCGGNDNNFYNENDCKKCCVWDWECNSASP A_0048_032 MDARRVAAVLLVLSVARSVTA-TDARCSEPLDMGHPGCSRVRIRWYYNQVEEMCLPFQYTGCGGNDNNFYNENDCKKCCVWDWECNSASP betulinusAMP44685 MDVRRVPAVLLVLSMARSVTA-IDARCNEPLNLGNTGCDEVRIRWYYNQGNVACQTFQYTGCGGNRNNFYNRDDCKKCCRWDMECVSAGR [Conkunitzin-10] [Framework XXII] [ /--------------------------C------C------------C--------C---------------C-------C------------C---C-----------------------------/----Post-----] /--------------------KU--motif---------------------/ V_CG13_012 ----------------------MEKDLCRGEIMDCRKAIMLKDFNAICQLEADVGPCSGTFPRWFYNSDMRKCQLFDYGGCRGNENRFDTEEECMELCNLDKESMMERRSRIEKEVVMEKQAMMEKQRQMEKQAMMEKQRQM V_1302_149 ----------------------MEKDLCRGEIMDCRKAIMLKDFNAICQLEADVGPCSGTFPRWFYNSDMRKCQLFDYGGCRGNENRFDTEEECMELCNLDKESMMERRSRIEKEVVMEKQAMMEKQRQMEKQAMMEKQRQM V_1258_086 ----------------------MEKDLCRGEIMDCRKAIMLKDFNAICQLEADVGPCSGTFPRWFYNSDMRKCQLFDYGGCRGNENRFDTEEECMELCNLDKESMMERRSRIEKEVVMEKQAMMEKQRQMEKQAMMEKQRQM A_0875_031 ----------------------MEKDLCRGEIMDCRKAIMLKDFNAICQLEADVGPCSGTFSRWFYNGDMRKCQLFDYGGCRGNENRFDTEEECMELCNLDKESMME----------------------------------- A_0239_451 ----------------------MEKDLCRGEIMDCRKAIMLKDFNAICQLEADVGPCSGTFPRWFYNSDMRKCQLFDYGGCRGNENRFDTEEECMELCNLDKESMME----------------------------------- A_0025_050 ----------------------MEKDLCRGEIMDCRKAIMLKDFNAICQLEADVGPCSGTFPRWFYNSDMRKCQLFDYGGCRGNENRFDTEEECMELCNLDKESMMERRSRIEKEVVMEKQAMMEKQRRMEKQAMMEKQRHM magusDAC80558 MKERWRMFISKSNETENCGIHLMEKDLCRVEIMDCRKAIMLKDFNAICQMEADVGPCSGTFPRWFYNSGMKKCQLFDYGGCRGNDNRFDTEEECMELCNLDKESMMERRSRIEKEVVMEKQAMMEKQRQMEKQAMMEKQRQM [Conkunitzin-11] {Framework IX] [ /-----Signal----/Pr/C--------C---------------C-------C------------C---C--] /--------------------KU--motif-----------------------/ V_1258_156 MWVVLICLLGLCLSANADDRCTMPPVTGVCMAYFPRWYYDSTSGQCKQFVWGGCGGNANNFLSKEECFQACGNH [Conkunitzin-12] [Framework XXII] [ /-------Signal-----/-----C-------------------------C-------------------C--C---C-C------------------------C--------------------C---C----] /----------------------KU--motif----------------------/ /-------------------KU--motif---------------------/ A_0885_008 ----------------------------AKDEGTESQNITRFFFDRDTGTCEAF-YYTGGNNDTFPNRFNNCPVCENTCKCKLRMDPGTGQRPRTRYYHSSDGSGCRSFQYRGIGGNANNFDSESACINECELQHG A_0875_135 ---------------------SSNACDKAKDEGTESQNITRFFFDRDTGTCETF-YYTGGNNDTFPNRFNNCPVCENTCKCKLRMDPGTGQRPRTRYYHSSDGSGCRSFQYRGIG--------------------- V_CG13_016 MDALRFSAVLLILAMACVMTESIHICDKAKDEGTGSQNIASYFFDRDTGTCETF-NYTGGNYDTFPNRFNNCPVCENTCKCKLRKDPGTGERRRTRYYHSSDGSGCLPFEYRGIGGNANNFDSESACINECEL--- V_1302_039 MDALRFSAVLLILAMACVMTESIHICDKAKDEGTGSQNIASYFFDRDTGTCETF-NYTGGNYDMFPNRFNNCPVCENTCKCKLRKDPGTGERRRIRYYHSSDGSGCLPFEYRGIGGNANNFDSESACINECEL--- A_1387_334 MDALRFSAVLLILAMACVMTESIHACDKAKDEGTGSQNIASFFFDRDTGTCETF-YYTGGNYDVFPNRFNNCPVCENTCKCKLRMDMGTGERPRTRYYHSSDGSGCQSFQFRGIGGNANNFDSKSACINECELQHG A_0025_433 MDALRFSAVLLILAMACVMTESIHPCDKAKNEGTGSQNITRSFFDRDTGTCETF-YYTGGNYDMAPNRFNNCPVCENSCKCKLRMDPGTGQRPRTRYYHSSDGSGCRSFQYRGIGGNANNFDSESACINECELHLG A_0520_321 ----------------CVMTESIHACDKAKDEGTESRNITRFFFDRDTGTCETF-YYTGGNNDTFPNRFNNCPVCENTCKCKLRMDPGTGQRPRTRYYHSSDGSGCRSFQYRGIGGNANNFDSESACINERELQHG betulinusAMP44684 MDALRFSAVLLILAMACFMTESTGVCDKDKVEGTGNLNLTRYFFDSDTETCETF-IYRGGNSDTFPNRFNYHSVCENTCQCKLRKDTGHGEAPRTRWYHSSDGSGCQSFQYLGSGGNANNFHTESECEMACEL--- K_0010_325 MDALRFSAVLLILAMACFMTESTGSCDKAKDEGTGNRNITSYFFDSATATCETFFFKGSGNNDPFPNRFNSHVDCENICKCKLRKDMGTGTRHRIRYYHNTDGSRCQSFIYYGMGGNTNNFQHDWECQNECEL--- [Conkunitzin-13] [Framework IX] [ /---------Signal-------/----C----------------------C--------------------C---C-------------] /--------------------KU-motif--------------------/ V_1278_007 MSSMRLSVTLLIVLSVFSIKQTTAIPRFCYLLIEEGKCSNFQLRYAHHKGECVPFLYGGCGGNINRFDTKEACERRCTWKHIRPRYPLELD [Superfamily D] [Framework XX] [ /--------Signal--------/-------Pro----------/ /----C-----------CC----C---CC----C-C---------C-C-] A_0855_010 MPRLEMMLLVLLILPLPDFNVADGQAIQGDGQGDGMDRYLLRGDR DVNRPCHAYNPGSPWGRCCRTVMCGSRCCDYSFCRCV-SETKGSACVCTL A_0875_042 MPRLEMMLLVLLILPLPDFNVADGQAIQGDGQGDGMDRYLLRGDR DVNRPCHAYNPGSPWGRCCRTVMCGSRCCDYSYCRCV-SETKGSACVCTL A_0055_024 MPRLEMMLLVLLILPLPDFNVADGQAIQGDGQGDGMDRYLLRGDR DVNRPCHAYNPGSPWGRCCRTVMCGSRCCDYSYCRCV-SEKKGSACVCTP A_0055_026 MPRLEMMLLVLLILPLPYFNAAGGQAVQGDGQGDRMDRYLQRGDR AVIATCHPYNPGSPWGRCCRTVMCGSRCCDYSYCRCV-SESGGTACVCTS A_0039_130 MPRLEMMLLVLLILPLPDFNVAGGQAVQGDGQGDRMDRYLQRGDR AVIATCHPHHPGSPWGRCCRTLMCGKVCCSYAHCHCI-SDEKGLGCSC-- V_CG13_188 MPRLEMMLLVLLILPLPYFNAAGGQAVQGDGQGDGMDRYLQRGDR AVIAACHPNNPGSPWGRCCTTVMCGSVCCNYAHCSCIYHKDRGHGCDC-- V_1302_042 MPRLEMMLLVLLILPLPYFNAAGGQAVQGDGQGDGMDRYLQRGDR AVIATCHPNNPGSPWGRCCTTVMCGSVCCNYAHCSCMYHKDRGHGCAC-- V_1258_068 MPRLEMMLLVLLILPLPYFNAAGGQAVQGDGQGDGMDRYLQRGDR AVIATCHPNNPGSPWGRCCTTVMCGSVCCNYAHCSCMYHKDRGHGCAC-- A_0885_107 MPRLEIMLLVLLILPLPYFNAAGGQAVQGDGQGDRMDRYLQRGDR AVIATCHPNHPGSPWGRCCTTVMCGSLCCNYSHCICIYHKDRGHGCDCR- A_0885_108 MPRLEMMLLVLLILPLPYFNAAGGQAVQGDGQGDRMDRYLQRGDR AVIATCHPNHPGSPWGRCCTTVMCGSLCCNYSHCICIYHKDRGHGCDCR- A_1387_294 MPRLEMMLLVLLILPLPYFNAAGGQAVQGDGQGDRMDRYLQRGDR AVIATCHPHHPGSPWGRCCTTVMCGSLCCNYAHCSCIYHKDRGHGCDCR- A_0031_193 MPRLEMMLLVLLILPLPYFNAAGGQAVQGDRQGDRMDRYLQRGDR AVIATCHPNHRGSPWGRCCRTKMCGSVCCSYAHCTCVNHKDRGQGCHCE- A_0239_337 MPRLEMMLLVLLILPLPYFNAAGGQAVQGDGQGDRMDRYLQRGDR AVIATCHPYNPGSPWGRCCRNKMCGSVCCRYAHCTCVNHKDRGQGCHCE- A_0039_128 MPRLEMMLLVLLILPLPYFNAAGEQAVQG-------DRYLQRGDR AVIATCHPNQPGSPWGRCCRTKMCGSVCCNYAQCSCVYHADRGDGCHCE- A_0025_381 MPRLEMMLLVLLILPLPYFNAAGGQAVQGDGQGDRMDRYLQRGDR AVIATCHPNYPGSPWGRCCTTKMCGSVCCNYAHCSCVYHSDMGDGCSC-- A_1387_292 MPRLEMMLLVLLILPLPDLNAAGGQAVQGDGQGDRMDRYLQRGDR AVIATCHPHHPGSPWGRCCRTLMCGNVCCNYAHCHCIS-DENGLGCSC-- A_0239_336 MPRLEMMLLVLLILPLPYFNAAGGQAVQGDGQGDRMDRYLQRGDR AVIATCHPYNPGSPWGRCCRTVMCGSRCCDYSYCRCVS-ESGGTACVCTS A_0031_194 MPRLEMMLLVLLILPLPYFNAAGGQAVQGDRQGDRMDRYLQRGDR AVIATCHPYYPGSPWGRCCRTVMCGSRCCDYSHCRCAS-EPKGAACVCTS A_0520_120 MPRLEMMLLVLLILPLPYFNAAGGQAVHGDGQGDRMDRYLQRGDR AVIATCHRNQPGSPWGRCCRTKMCGSVCCNHAQCSCVYHADRGDGCHCE- A_0048_012 MPRLEMMLLVLLILPLPYFNAAGGQAVHGDGQGDRMDRYLQRGDR AVIATCHRNQPGSPWGRCCRTKMCGSVCCNHAQCSCVYHADRGDGCHCK- A_0885_109 --------------------------VQGDGQGDGVDRFLLRGDR GVLSKRHTHERDAGWERCCLTKLCGSVCCPRSNCNCI-NDERGPGCSCE- A_0039_129 -------------------------AVQGDGQGNGMDRYLLRGGR GVLRECRTDQQGSRYGRCCLTKMCYGFCCPQKNCNCVYDDIRGAGCACW- V_CG13_189 MPRLEMMLLVLLILPLPYFNAAGGQAVQGDGQGDGMDRFFLRGDR GVLSERHTREPGSGWGRCCLTKMCGDVCCTRRNCNCVHNADRGHGCSC-- V_1302_041 MPRLEMMLLVLLILPLPYFNAAGGQAVQGDGQGDGMDRFFLRGDR GVLSERHTRESGSGWGRCCLTKMCGDVCCPRRNCNCVHNADRGPGCSC-- V_1258_069 MPRLEIMLLVLLILPLPYFNAAGGQAVQGDGQGDGMDRFFLRGDR GVLSERHTRESGSGWGRCCLTKMCGDVCCPRRNCNCVHNADRGPGCSC-- A_1387_293 MPRLEMMLLVLLILPLPYFNAAGGQAVQGDGQGDGVDRYLLRGDI GVLSKRHTHERGTGWGRCCLTKMCGSVCCPQKNCNCVYDAIRGPGCSC-- A_0520_119 MPRLEMMLLVLLILPLPYCNAAGGQAVKGDGQGDGVDRYLLRGDR GVLSKRHTHERGTGWGRCCLTKMCGSVCCPQKNCNCVNDGIRGPGCSC-- A_0031_195 MPRLEMMLLVLLILPLPYCNAAGGQAVQGDGQGDGVDRYLLRGDR GVLSKRHTHERGTGWGRCCLTKMCGSVCCPEKNCNCVSDDIRGPGCSC-- A_0239_335 MPRLEMMLLVLLILPLPYFNAAGGQAVQGDGQGDGVDRYLLRGDR GVLSKRHTHERGTGWGRCCLTKMCGSVCCPEKNCNCVSGDTRGPGCSC-- ermineusAXL95488 MPRLEMMLLVLLILPLPYFNAAGGQAVQGDGQGDRMDRYLQRGDR AVIATCHPNYPGSPWGRCCTTKMCGSVCCNYAHCSCVYHSDMGDGCSC-- capitaneusP0CE26 MPKLEMMLVVLLIFPLFYFDAAGGQAVQGDRRGDGLARYLQRGDR NDESECIISTPGSSWGRCCLTRMCGTMCCPRSGCYCVYHWRRGHGCACSD mustelinusP0CE28 MLKLEMMLVVLLILPLFYFD-AGGQVVQGDWRSDGLARYLQRGDR -DVRECNINTPGSSWGKCCLTRMCGTMCCARSGCTCVYHWRRGHGCSCPG vexillumP0C1W5 MPKLEMMLLVLLIFPLSYFIAAGGQVVQVDRRGDGLAGYLQRGDR -DVQDCQVSTPGSKWGRCCLNRVCGPMCCPASHCYCVYHRGRGHGCSC-- rattusP0CE34 MPKLEMMLLVLLILPLSYFSAAGGQVVQGDLRSDVLARYLQRGDR -DARECQVNTPGSRWGKCCLNRMCGPMCCPESHCYCVYHRRRGHGCSC-- milesAKB91377 MPKLEMMLLVLLILPLYYFSAAGGQVVQGDWRGEGLARYLQRGDR -DAQECQVVTPGSKWGRCCLNRVCGPMCCPASHCYCIYHRGRGHGCSC-- vitulinusP0CE36 MPKLAVVLLVLLILPLSYFDA-GGQAVQGDWRGNRLARDLQRGGR DDESECIINTRDSPWGRCCRTRMCGSMCCPRNGCTCVYHWRRGHGCSCPG [Superfamily E-1] [Framework XXII] [ /-----Signal----/ /--------C---------C-----C-----------C---C-C-----C-----------------C--] A_0855_031 MMTRVFIAMFFLLALTE GWPRLTDSDCELGRNMHITCKQLDQCGVIEKKDGQLTCKLRCKCKPGKRCLRKENIDWSDITTRIYHCPWP A_0055_068 MITRVFIAMFFLLSLTE GWPRLTDSDCELGRNMHITCKQLDQCGVIDKKDGQLTCKLRCKCKSGKRCLREENIDWSDITTRIYHCPWP A_0039_041 MITRVFIAMFFLLSLTE GWPRLTDSDCELGRNMHITCKQLDQCGVIDKKDGQLTCKLRCKCKSGKRCLREENIDWSDITTRIYHCPWP A_0885_019 MMTRVFIAMFFLLALTE GWPRLTDWDCKLGRNMHITCEQLDQCGVITKKDGQLTCKLRCKCKPGKRCLREENIDWSRITTRIYHCPWP V_CG13_066 MMTRVFIAMFFLLALTE GWPRLNDWDCELGRNMHITCKQLEQCGFIEKKDGQLTCKLRCRCKPGKRCLRKEKIDWSDITTRIYHCPWP V_1278_048 MMTRVFIAMFFLLALTE GWPRLNDWDCELGRNMHITCKQLEQCGFIEKKDGQLTCKLRCRCKPGKRCLRKEKIDWSDITTRIYHCPWP V_1302_031 MMTRVFIAMFFLLALTE GWPRLNDWDCELGRNMHITCKQLEQCGLIEKKDGQLTCKLRCRCKPGKRCLRKEKIDWSDITTRIYHCPWP V_1258_055 MMTRVFIAMFFLLALTE GWPSLNDWDCELGRNMHITCKQLEQCGLIEKKDGQLTCKLRCRCKPGKRCLRKEKIDWSDITTRIYHCPWP A_0031_038 MMTRVFIAMFFLLALTE GWPRLTDWDCELGRNMHITCKQLDQCGVIDKKDGQLTCKLRCKCKSGKRCLREENIDWSDITTRIYHCPWP A_0239_042 MMTRVFIAMFFLLALTE GWPRLTDWDCELGRNMHITCKQLDQCGVIYKKDGQLTCKLRCKCKPGKRCLREKNIDWSDITTRIYHCPWP A_0048_243 MITRVFIAMFFLLALTE GWPRLTDSDCELGRNMHITCKQLDQCGVIEKKDGQLTCKLRCKCKPGKRCLRKENIDWSDITTRIYHCPWP A_0520_181 MITRVFIAMFFLLALTE GWPRLTDSDCELGRNMHITCKQLDQCGVIDKKDGQLTCKLRCKCKPGKRCLRKENIDWSDITTRIYHCPWP A_0025_217 MITRVFIAMFFLLALTE GWPRLTDSDCELGRNMHITCKQLDQCGVIDKKDGQLTCKLRCKCKPGKRCLRKENIDWSDITTRIYHCPWP A_1387_202 MMTRVFIAMFFLLALTE GWLRLTDSDCELGRNMHITCTQLDQCGVIHKEDGQLTCKLRCKCKPGKRCLREENIDWSRINSRIYHCPWP ermineusAXL95533 MMTRVFIAMFFLLALTE GWPRLTDSDCELGRNMHITCKQLDQCGVIEKKDGQLTCKLRCKCKPGKRCLRKENIDWSDITTRIYHCPWP [Superfamily E-2] [Framework XXII] [ /-----Signal----/ /--------C-----------C-----C-----------C---C-C-----C-----------------C----] A_0855_030 --------------LTE GWPRLYDRNCQNGLNMHYSNKCDTQQQCAIIRKRKGQLTCKLMCKCEPGVDCLHGEYIDWDYRTAKIIYCP---- A_0055_218 MMTRVFIAMFFLLALTE GWPRLYDRNCQNGLNMHYSYKCDTQQQCAIIRKRKGQLTCKLMCKCEPGIDCLHGEYIDWDYRTAKIIYCP---- A_0048_244 MITRVFIAMFFLLALTE GWPRLYDRNCQNGLNMHYSYKCDTQQQCAIIRKRKGQLTCKLMCKCEPGVDCLHGEYIDWDYRTAKIIYCP---- A_1387_203 MMTRVFIAMFFLLALTE GWPRLYDRNCQNGLNMHYSYTCDTQRQCAIIRKRKGQLTCKLMCKCEPGVDCLHGEYIDWDYRTA---------- A_0031_037 MMTRVFIAMFFLLALTE GWPRVYDRNCQNGLNMH--YTCDTQRQCAIIHKRKGQLMCKLMCKCVPGVDCLHGEYIDWDYRTAKIIYCP---- K_0010_140 -MTRVFIAMFFLLALTE GWPRLHDDNCENGPNMHYSYTCDTQQQCAIIRKRNGQWTCKLMCKCEPGVDCLHGEYIDWDDRTAK--------- K_0010_141 -MTRVFIAMFFLLALTE GWPRLHDDNCENGPNMHYSYTCDTQQQCAIIRKRNGQWTCKLMCKCEPGVDCLHGEYIDWDDRTAKIIYCP---- ermineusAXL95534 MMTRVFIAMFFLLALTE GWPRLYDRNCQNGLNMHYSYKCDTQQQCAIIRKRKGQLTCKLMCKCEPGIDCLHGEYIDWDYRTAKIVY------ betulinusAMP44647 -MTRVFVAMFFLLALTE GWPPLYDRNCENGPNMHYSYTCGTKRKCAIIRKRNGQSTCKLMCKCEPGVDCLHGENIDWDDRTAKIIYCP---- gloriamarisGFNK01000011 MMTRVFLAMFFLLVLTE EWPELSDSDCERGPNMH--ITCFKDQSCGLIVKRNGRLSCTLNCKCRRNESCLPSEEVDWDHRNMKIVICPKPWF magusQFQ60997 MMTRVFFAMFFLMALTE GWPRLYDSDCVRGRNMH--ITCFKDQTCGLTVKRNGRLNCSLTCSCRRGESCLHGEYIDWDSRGLKVHICPKPWF [Superfamily F-1] [No Framework] [ /------------Signal------/--Pro--/ /--------------C-----------------------------------C-----------] A_0875_012 ----MQRGVVLLGVVAFLALWPQTAAKLYDLNDR DVMAMVEHGQRLMHACATANSYIDDPWWMLDLRDFK-EKRVYHSMLRELISCLNTFLRKRRQAP A_0855_034 ----MQRGVVLLGVVAFLALWPQTAAKLYDLNDR DVRAMVEHGQRLMHACATANSYIDDPWWMLDLRDFK-EKRVYHSMLRELISCLNTFLRKRRQAP A_0885_069 ----MQRGVVLLGVVAFLALWPQTAAKLYDLNDR DVLAMVDYGQKLMHACATANSYIDDPWWMLDLGDFK-EKRVYHSMLRELISCLNTFLRKRRQAP A_0055_014 ----MQRGVVLLGVVAFLALWPQTAAKLYDLNDR DVMAMVDFGQKLMHACATANSYIDDPWWMLDLRDFE-EKRVYHSMLRELISCLNTFLRKRRQAP A_0039_053 ----MQRGVVLLGVVAFLALWPQTAAKLYDLNDR DVMAMVDFGQKLMHACATANSYIDDPWWMLDLRDFE-EKRVYHSMLRELISCLNTFLRKRRQAP V_CG13_010 ----MQRGVVLLGVFAFLALWPQTAAKLYDLYDR DVLAMVDYGQKLMHACAIANSYIDDPWWMLDLWAFK-EKRVYHSMVKELKFCLDTFLQKRRQAP V_1302_061 ----MQRGVVLLAVVAFLALWPQTAAKLYDLYDR DVLAMVDYGQKLMHACATANSYIDDPWWMLDLWAFK-EKRVYHSMVKELKFCLDTFLQKRRQAP A_0239_073 ---MMQRGVVLLGVVAFLALWPQTAAKLYDLNDR DVLAMVDHGQKLMHACATANSYIDDPWWMLDLRDFK-EKRVYHSMLRELISCLNTFLRKRRQAP A_0031_196 ---MMQRGVVLLGVVAFLALWPQTAAKLYDLNDR DVLAMVDHGQKLMHACATANSYIDDPWWMLDLRDFK-EKRVYHSMLRELISCLNTFLRKRRQAP A_0025_074 ----MQRGVVLLGVVAFLALWPQTAAKLYDLNDR DVLAMVDYGQKLMHACATANSYIDDPWWMLDLGDFK-EKRVYHSMLRELISCLNTFLRKRRQAP A_1387_259 ----MQRGVVLLGVVAFLALWPQTAAKLYDLNDR DVLAMVDYGQKLMHACATANSYIDDPWWMLDLGDFK-EKRVYHSMLRELISCLNTFLRNRRQAP marmoreusP0DM17 ----MQRGAVLLGVVALLVLWPQAGAELYDVNDP DVRAMVIDGQKLMHDCAIANDYIDDPWWTLNLGAFE-EKRVYHSMLSELVFCLNAFLQRRQQAP magusQFQ60998 ----MQRGAVLLGVVAFLALWSQAAADVYDLNDP DVLAVVDEGQKLMHACSIANKYTYDPWWKLNILAFK-EMRVYHSMMGDMVTCLNHFFRRRHGEH [Superfamily F-2] [No Framework] [ /------------Signal------/--------Pro-------/ /---C-----------------------------------C-----------] A_0885_068 -------------------LWPQVAAKPYDLDDADVWAMVDYGKK LMHACAIANNYIDDIWSLYNIAAFK-DKSLYHSMLNDMVTCLNSFLRSRQ--- V_1258_077 ----------------FLALWPQVAAKPYDLDDADVWAMVDYGKK LMHACAIANNYIDDIWSLYNIAAFK-DKSLYHSMLNELVTCLNTFLRRRQ--- V_1258_076 --------------------WPQTAAKLYDLYDRDVLAMVDYGQK LMHACAIANNYIDDIWSLYNIAAFK-DKSLYHSMLNELVTCLNTFLRRRQ--- A_0520_079 MVSTMQRGVVLLGMVAFLALWPQVAAKPYDLDDADVWAMVDYGKK LMHACAIANNYIDDIWSLYNIAAFK-DKSLYHSMLNDLVTCLNSFLRSRQ--- A_0048_177 ----MQRGAVLLGVVAFLALWPQVAAKPYDLDDADVWAMVDYGKK LMHACAIANNYIDDIWSLYNIAAFK-DKSLYHSMLNDMVTCLNSFLRSRQ--- A_0520_081 MVSTMQRGVVLLGMVAFLALWPQVAAKPYDLDDADVWAMVDYGKK LMHACAIANNYIDE--------------------------------------- K_0010_255 ----------------------------------DVWPTVDYGKK LMHACAIANKYIDDIWSLYNIAAFK-DKSLYHSMLNDLVTCLNSFLRSRQ--- K_0010_074 MVSTMQRGAVLLGVVAFLALWPQVAAKPYDLDDADVWAMVDYGKK LMHACAIANNYIDDIWSLYNIAAFK-DKSLYHSMLNDLVTCLNSFLRSRQ--- K_0010_356 ------------------------AAKPYDLDYADVWAMVYYGKR LMEACATAN-DMDNSWSTYSVEDFE-DKGLYHTMLLDLVPCLNIFLRKRQ--- ermineusAXL95638 ----MQRGAVLLGVVDFIALWPQVAAKPYDLDDADVWAMVDYGKK LMHACAIANNYIDDIGELDKSAALK-DESRDHSTVN----------------- ermineusAXL95632 ------------------------------------------GQK LMNTCAVANNYIDNTWSLYDVDAFK-DKNLYHSMLNELVSCLGTFLQTRHTAS victoriaeJAB84709 ----MQRGAVLLGVVAFLALWPQAGAEPYNLNDPDVRAMINDGRK LMDTCAKANHYIADRWSTYRIEYLE-DKGLYHRMLRELVPCLNNFLRTRQEAP gloriamarisGFNK01000012.1 ----MQRGAVLLGVVAFLALWPQAGAEPYNLNDPDVRAMINDGRK LMDTCAKANHYIADRWSTYRIEYLE-DKGLYHRMLRELVPCLNNFLRTRQEAP betulinusAMP44604 ----MQRGVVLLGVVAFLALWPQAAAEVYDLGDPNVWSVVDHTQR LMHTCAQANSYTQNKWSKYNVAAFK-EKSLFHSMYSDLVPCMDYFLQTRH--- magusQFQ61005 ---MMQRGAVLLGVVAFLALWPQAAAKVYNLHDTEVWAVVAYSKR VMHACAIANSHMDDPWLVVDVKDFE-ERSLFHSMYKAMVSCLEDFFQQRP--- [Superfamily F-3] [No Framework] [ /------------Signal------/-------Pro--------/ /---C-----------------------------------C-----------] A_0055_344 --------------------------------------------- -----DMAIDGKDSSWSAYSVEDLKEDKRLYHRMLLDLVPCLNKFLDERYETP A_0855_035 ----MQRGVVLLGVVAFLALWPQTAAKLY---DADVSAMAYYGKR LMEACDMAIDGKDSSWSAYSVEDLKEDKRLYHRMLLDLVPCLNKFLDERYETP A_0855_036 ----MQRGVVLLGVVAFLALWPQTAAMLY---DADVSAMAYYGKR LMEACDMAIDGKDSSWSAYSVEDLKEDKRLYHRMLLDLVPCLNKFLDERYETP A_0885_070 ----MQRGVVLLGVVAFLALWPQTAAKLY---DADVSAMAYYGKR LMEACDMAIDGKDSSWSTYSVEDLKEDKSLFHRMLLDLVPCLNKFLDERYETP A_0885_067 ----MQRGVVLLGVVAFLALWPQTGAKLY---DADVSAMAYYGKR LMEACDMAIDGKDSSWSTYSVEDLKEDKSLFHRMLLDLVPCLNKFLDERYETP V_CG13_011 --------------------------------------------R LMEACDMAIHGKESSWSTYSVEDLEKDKRLYHRMLLDLVPCLNKFLDERYETP V_1258_075 ----MQRGVVLLGVVAFLALWPQTAAKLY---DADVSAMAYYGKR LMEACDMAIHGKESSWSTYSVEDLEKDKRLYHRMLLDLVPCLNKFLDERYETP V_1302_059 ----MQRGVVLLAVVAFLALWPQTAAKLY---DADVSAMAYYGKR LMEACDMAIHGKESSWSTYSVEDLEKDKRLYHRMLLDLVPCLNKFLDERYETP V_1302_060 ----MQRGVVLLAVVAFLALWPQTAAKLY---DADVSAMAYYGKR LMEACDMAIHGKESSWSTYSVEDLEKDKRLYHRMLLDLVPCLNKFLDERRQAP A_0520_080 ----MQRGVVLLGMVAFLALWPQTAAKLY---DADVSAMAYYGKR LMEACDMAIDGKDSSWSTYSVEDLKEDKLLYHRMLLDLVPCLNKFLDERYETP A_0048_178 ----MQRGVVLLGVVAFLALWPQTAAKLY---DADVSAMAYYGKR LMEACDMAIDGKDSSWSTYSVEDLKEDKLLYHRMLLDLVPCLNKFLDERYETP A_0025_073 ----MQRGVVLLGVVAFLALWPQTAAKLY---DADVSAMAYYGKR LMEACDMAIDGKDSSWSTYSVEDLKEDKSLYHRMLLDLVPCLNKFLDERYETP A_0239_074 ----MQRGVVLLGVVAFLALWPQTAAKLY---DADVSAMAYYGKR LMEACDMAIDGKDSPWSTYSVEDLKEDKRLYHSMLLDLVPCLNKFLDERYETP A_0031_197 ---MMQRGVVLLGVVAFLALWPQTAAKLY---DADVSAMAYYGKR LMEACDMAIDGKDSSWSTYSVEDLKEDKRLYHSMLLDLVPCLNKFLDERYETP A_1387_260 ----MQRGVVLLGVVAFLALWPQTAAKLY---DADVSAMAYYGKR LMEACDMAIDGKDSSWSTYSVEDLKKDKRLYHRMLLDLVPCLNKFLDERREVP ermineusAXL95527 ----MQRGAVLLGVVAFLALWPQTAAKLY---DADVSAMAYYGKR LMEACDMAIDGKDSSWSAYSVEDLKEDKRLYHRMLLDLVPCLNKFLDERYETP [Superfamily H-1a] [Framework VI/VII] [ /-------Signal-------/---------Pro--------/ /----------C----C---CC--------C----C------------] A_0855_026 MNTAGRLLLLCLALGLVFESLGIPVADDVEADRDTDPGDEDQR SLDTIETGQAKCGRGTCRLGCCKTINGEDKCRELDCN------------ A_0855_027 MNTAGRLLLLCLALGLVFESLGIPVADDVEADRDTDPDDEDPR GLNTFETGQAKCGRGTCRLGCCRTINGEEKCREFDCD------------ A_0055_029 MNTAGRLLLLCLALGLVFESLGIPVADDVEADRDTDPDDEDPR GLNTFETGQAKCGRGTCRLGCCRTINGEEKCREFDCD------------ A_0039_095 MNTSGRLLLLCLALGLVFESLGIPVADDVEADRDTDPDDEDPR GLNTFETGQAKCGRGTCRLGCCRTINGEEKCREFDCD------------ A_0875_026 MRTSGRLLLLCLALGLVFESLGIPVADDVEADRDTDPDDEDPR GLKTFETGQAKCGRGTCRLGCCRTINGEEKCREFDCD------------ V_CG13_102 MNTAGRLLLLCLALGLVFESLGIPVADDVEADRDTDPDDEDPR GLDTLETGQAKCGRGTCKLGCCRTINREEKCREFNCN------------ V_1302_133 MNTAGRLLLLCLALGLVFESLGIPVADDVEADRDTDPDDEDPR GLDTFETGQAKCGRGTCKLGCCRTINREEKCREFNCN------------ V_1258_037 MNTAGRLLLLCLALGLVFESLGIPVADDVEADRDTDPDDEDPR GLDTFETGQAKCGRGTCKLGCCRTINREEKCREFNCN------------ V_1278_046 MRTSGRLLLLCLALGLVFESLGKLVADDVEADRDTDPDDEDPR GLDTFETGQAKCGRGTCKLGCCRTINREEKCREFNCN------------ A_0855_028 MNTAGRLLLLCLALGLVFESLGIPVADDVEADRDTDPDDEDPR GLDPFGTSQTKCGSGTCRFGCCKTINAEEKCRELDCD------------ V_1302_135 MNTAGRLLLLCLALGLVFESLGIPVADDVEADRDTDPDDEDPR GLATFGTSQTKCGSGTCTFGCCRTINGEERCRELDCDF----------- A_0039_094 MNTSGRLLLLCLALGLVFESLGIPVADDVEADRDTDPGDEDQR SLDTIGISQTKCGSGTCRFGCCRTINGEERCRELDCDF----------- V_CG13_106 MNTAGRLLLLCLALGLVFESLGIPVADDVEADRDTDPDDEDPR DLDLLVTGTGTCGGDPCTFGCCRTINGERMCRELDCH------------ V_1302_132 MNTAGRLLLLCLALGLVFESLGIPVADDVEADRDTDPDDEDPR FLETLVTGTGTCGGDPCTFGCCRTINGEERCRELDCD------------ V_1278_047 -----RLLLLCLALGLVFESLGIPVADDAEADIDTDPDDEDPR DLDPLETGQGKCGDVTCRFGCCETIDGERMCRELDCD------------ V_CG13_103 MNTAGRLLLLCLALGLVFESLGIPVADDAEADIDTDPDDEDPR DLDPLETGQGKCGDVTCRFGCCETIDGERMCRELDCH------------ V_CG13_105 ------------------------------------------- ----VETGQGKCGDVTCRFGCCETIDGERMCRELDCH------------ V_1302_131 MNTAGRLLLLCLALGLVFESLGIPVADDAEADIDTDPDDEDPR DLDPLETGQGKCGDVTCRFGCCETINGERMCRELDCR------------ V_1302_134 ------------------------------------------- ----METGQGKCGDVTCRFGCCETINGERMCRELDCR------------ V_CG13_104 MNTAGRLLLLCLALGLVFESLGIPVADDVEADRDTDPDDEDPR GLETLPSSEVECGRGTCSFGCCVN----DECRELDCD------------ V_1302_136 MNTAGRLLLLCLALGLVFESLGIPVADDVEADRDTDPDDEDPR GLDPLPSIEVECGRGTCSFGCCVN----DECKEFNCD------------ A_0885_097 -----RLLLLCLAMGLVFESLGIPVADDVEADRDTDPDDEDPR GLNTLPSSEVECGSRTCRWDCCEN----EVCRELDCD------------ A_0875_027 -----RLLLLCLALGLVFESLGIPVADDVEADRDTDPDDEDPR GLNTLPSSEVECGSRTCRWDCCEN----EVCRELDCD------------ A_0055_028 -----RLLLLCLALGLVFESLGIPVADDVEADRDTDPDDEDPR GLNTLPSSEVECGSRTCRWDCCEN----EVCRELDCD------------ A_0039_096 -----RLLLLCLALGLVFESLGISVADDVEADRDTDPDDGDPR GLDTLPSSEGVCGSGTCSWNCCKN----GECREIGCD------------ A_1387_217 MNTSGRLLLLCLALGLVFESLGIPVADDVEADRDTDPDDEDPR GLDPLETGQGKCGDVTCRFGCCKTIDGERMCRELDCR------------ A_0031_399 ------------------------------------------- ----VETGQGKCGDVTCRFGCCKTIDGERMCRELDCR------------ A_0031_400 MNTAGRLLLLCLALGLVFESLGIP-----KLTIDTDPDDEDPR GLDPLETGQGKCGDVTCRFGCCKTIDGERMCRELDCR------------ A_1387_216 MSTAGRLLLLCLALGLVFESLGIPVADDVEADRDTDPDDEDPR GLDTFETGQAKCGRGTCKLG----------------------------- A_0031_401 MNTAGRLLLLCLALGLVFESLGIPVADDVEADRDTDPDDEDPR GLNTFETGQAKCGRGTCRLGCCRTIDGEEKCREFDCD------------ A_0025_070 MNTAGRLLLLCLALGLVFESLGIPVADDVEADRDTDPDDEDPR GLNTFETGQAKCGRGTCRLGCCRTINGEEKCREFDCN------------ A_0239_115 MNTAGRLLLLCLALGLVFESLGIPVADDVEADRDTDPDDEDPR GLNTFKTGQAKCGRGTCRLGCCRTINGEEKCREFKCD------------ A_0031_398 MNTSGRLLLLCLALGLVFESLGIPVADDVEADRDTDPGDEDQR GLDTIKTGQAKCGRGTCRLGCCRTIDGEEKCREFKCD------------ A_0048_182 MNTSGRLLLLCLALGLVFESLGIPVADDVEADRDTDPGDEDQR SLDTIGISQTKCGSGTCRFGCCRTINGEERCRELDCDF----------- A_0520_161 MNTAGRLLLLCLALGLVFESLGIPVADDVEADRDTDPDDEDQR GLDPIGISQTKCGSGTCRFGCCRTINGEERCRELDCDF----------- A_0520_162 MNTAGRLLLLCLALGLVFESLGIPVADDVEADRDTDPGDEDQR SLDTIGTGETKCGSGTCRFGCCKTIDGKEKCRELDCD------------ A_1387_215 MNTSGRLLLLCLALGLVFESLGIPVADDVEADRDTDPDDEDPR FLETLVTVTGTCGGHSCTFGCCRTINGERRCRELNCH------------ A_0025_071 MNTAGRLLLLCLALGLVFESLGIPVADDVEADRDTDPDDEDQR GLDPIGTSRTKCGSGTCRFGCCV----EEKCQELDCD------------ ermineusAXL95444 MNTAGRLLLLCLALGLVFESLGIPVADDVEADRDTDPDEEDPR ALEPVETGQATCGSGTCRFGCCRTIDGKQKCRELDCD------------ ermineusAXL95572 MNTAGRLLLLCLALGLVFESLGIPVADDVEADRDTDPDEEDPR ALEPLETGQATCGSGTCRFGCCRTIDGKQKCRELDCA------------ betulinusAMP44651 MNTAGRLLLLCLALGLVFESLGIPVADDVEADRDTDPDDEDQR NLNPWFVHEEKCGSGTCTFGCCETINGEPKCREFNCE------------ betulinusAMP44605 MNTAGRLLLLCLALGLVFESLGIPVADDVEADRDTDPDDEDPR GLSYWRT-LVDCGGVQCEFGCCETINGQERCREINCH------------ magusQFQ61011 MNTAGRLLLLCLALGLVFESLGIPVADDVKADRDTDPDDEDPR GLDLWEPIQTMCGDKLCDFGCCFTVFGVRKCKPFHCP------------ victoriaeW4VSB6 MNTAGRLLLLCLALGLVFESLGIPVADDVEAVRDTDPDEKDPS VHNSLKAVYGDCGGERCRFGCCKTDDGEEKCQHFGCP------------ gloriamarisGFNK01000014 MNTAGRLLLLCLALGLVFESLGIPVADDLEADRDTDPDDKDPS VHNYWR--NVNCGGVPCKFDCCR----EDRCREIDCD------------ victoriaeW4VS16 MNTAGRLLLLCLVLGLVFESLGIPVADDLEADRDTDPDEKDPS VHNYWR--NVNCGGVPCKFGCCR----EDRCREIDCD------------ TerebrasubulataP0DN50 MATSGRLLCVCLVMGLVFESLGYLTGREKRPAENLEASVQRRW YLNRRY--EVDCGGVLCQFGCCE----DDRCRELGCEFMDVLSRIRSAE [Superfamily H-1b] [Framework VI/VII] [ /-------Signal-------/-----------Pro-----------/ /-----C----C---CC--------C----C--------] A_0055_030 -------------MGLVFESLGIPVADDGDTDRDEGPVKKAAFIIDRR T--EVDCGGVQCEFGCCETIDGKEKCRELDCDATPDTESA A_0885_098 MNTAGRLLLLCLALGLVFESLGIPVTDDGDADRDEGPVKKAAFIIDRR T--EVDCGGVQCEFGCCETIDGKEKCRELDCDATPDTESA A_0885_099 MNTAGRLLLLCLAMGLVFESLGIPVTDDGDADRDAGPVQKAAFIIDRR T--EVDCGGVQCEFGCCETIDGKEKCRELDCDATPDTEPA A_0039_097 -----------------FESLGIPVTDDGDADRDAGPVQKAAFIIDSR T--EVDCGGVQCEFGCCETIDGKEKCRELDCDATSDTEPA A_0875_028 MRTSGRLLLLCLALGLVFESLGIPVTDDGDADRDAGPVQKAAFIIDRR T--EVDCGGVQCEFGCCETIDGKEKCRELDCDATPDTEPA A_0239_116 MNTAGRLLFLCLGLGLVFEYLGKPVTDDGDADRDASPVEKAAIIIHGR T--EVECGGVNCTFGCCE---------------------- [Superfamily H-2a] [No Signal, no Framework] A_0520_158 MRTSGRLLLLCLAVGLLFESQAHP-----MADARDATRNVGSDGTSVELSEMLERGQDSSAEEEQRQARDNGHDSDHVFIVNGHVIPFPV----------- A_0048_098 MRTSGRLLLLCLAVGLLFESQAHP-----MADARDATRNVGSDGTSVELSEMLERGQDSSAEEEQRPARDNGHDSDNVFIVDGNVIPFPV----------- A_0025_069 MRTSGRLLLLCLAVGLLLECQAHP-----MADARDATRNVGSDGTSVELSEMLERGQDSSAEEERRQARDNGQDSDHVSTAADHDIPFPVSQFSAAVF--- K_0010_024 MRTSGRLLLLCLAVGLLLESQAHP-----FADAGDATRNVGSDGTSVELSEMLERGQDSSAEKEQKKASARGH---------------------------- ermineusAXL95571 MRTSGRLLFLCLAVGLLLESQAHP-----IADAGDATRNVGSDGTSVELSKMIERGQDSSAEKGQRQAGARGHVSVYVTLKPDYDIPFPA----------- victoriaeW4VSG7 MRTSGRLLLLCLAVGLLLESQAHP-----NADAGDATRDVGSDRTSVELSKMLKGWQ---AEKGQRKASAPKKFYVYPPVRRSFY---------------- gloriamarisGFNK01000013 --ASGRLLLLCLAVGLLLESQGHS-----NADVGDATRDVGSDGTSVELSKMLKRWQ---AEKRQRKASARENFYVHPPSSRSFY---------------- magusQFQ61013 MRTSGRLLLLCLAVGLLLESQAHP-----NADAGDATRDVGSDRTSVELSKMLKRWQ---AEKGQRKATARKPVYVYPPGGRSFY---------------- V_1302_326 ------------AVGLLLECQAHP-----IADARDATRNVGSDGTSVELSEMLERGQDSSAE--------------------------------------- V_CG13_068 MRTSGRLLLLCLAVGLLLESQAHP-----IADAGDATRNVGSDGTSVELSKMIERGQDSSAEKGQRKASADRQDDDDDDTDYGHDIPLP------------ V_CG13_067 -----RLLLLCLAVGLLLESQAHP-----IADARDATRNVGSDGTSVELSKMIERGQD------------------------------------------- A_0885_042 MRTSGRLLLLCLAVGLLLESQAHP-----IADAGDATRNVGSDGTSVELSKMIERGQDSSAEKGQRKASADRQDDDDDDTDDGHDIPLP------------ A_0875_025 MRTSGRLLLLCLAVGLLLESQAHP-----IADAGDATRNVGSDGTSVELSKMIERGQDSSAEKGQRKASADRQDDDDDDTDDGHDIPLP------------ V_1302_130 MRTSGRLLLLCLAVGLLLECQAHP-----IADAGDATRNVGSDGTSVELSKMIERGQDSSAEKGQRKASADRQDDDDDDTDFGHDIPLPW----------- V_1278_045 MRTSGRLLLLCLAVGLLLECQAHP-----IADAGDATRNVGSDGTSVELSKMIERGQDSSAEKGQRKASADRQDDDDDDTDFGHDIPLPW----------- A_0239_113 MRTSGRLLLLCLAVGLLLESQAHP-----IADAGDATRNVGSDGTSVELSKMIERGQDSSAEKGQRKASADRQDDDDDDTDDGHDIPLP------------ A_0031_206 MRTSGRLLLLCLAVGLLLESQAHP-----IADAGDATRNVGSDGTSVELSKMIERGQDSSAEKGQRKASADRQDDDDDDTDDGHDIPLP------------ A_0025_067 MRTSGRLLLLCLAVGLLLESQAHP-----IADAGDATRNVGSDGTSVELSKMIERGQDSSAEKGQRKASADRQDDDDDDTDDGHDIPLP------------ A_1387_218 ----GRLLLLCLAVGLLLESQAHP-----IADAGDATRNVGSDGTSVKLSKMIERGQDSSAEKGQRKASADRQDDDDDDTDDGHDIPLP------------ A_0520_159 MRTSGRLLLLCLAVGLLLESQAHP-----IADAGDATRNVGSDGTSVELSKMIERGQVSSAEKGQRKASADRQDDDDDDTDDGHDIPLP------------ A_0048_097 MRTSGRLLLLCLAVGLLLESQAHP-----IADAGDATKNVGSDGTSVELSKRIERGQDSSAEKGQRKASADRQDDDDDDTDDGHDIPLP------------ A_0039_042 MRTSGRLLLLCLAVGLLLESQAHP-----IADARDATRNVGSDGTSVELSKMIDRGQDWSAEKGQRQASDNGHDKSMLRAADADPDHDIPFPFSLSSATLF A_0039_043 ----GRLLLLCLAVGLLLESQAHPQNKLKIADARDATRNVGSDGTSVELSKMIDRGQDWSAEKGQRQASDNGHDKSMLRAADADPDHDIPFPFSLSSATLF A_0055_204 MRTSGRLLLLCLAVGLLLESQAHP-----IADARDATRNVGSDGTSVELSKMIDRGQDWSAEKGQRQASDNGHDKSMLRATDADPDHDIPFPFSLSSATLF A_0875_024 MRTSGRLLLLCLAVGLLLESQAHP-----IADARDATRNVGSDGTSVELSKMIDRGQDWSAEKGQRQASDNGHDKSMLRAADADPDHDVPFPFSLSSAAFF A_0855_029 -----RLLLLCLAVGLLLECQAHP-----IADARDATRNVGSDGTSVELSKMIDRGQDWSAEKGQRQAS-------------------------------- A_0520_160 MRTSGRLLLLCLAVGLLLESQAHP-----IADAGDATRNVGSDGTSVELSKMIDRGQDWSAEKGQRQASDNGHDKSMLRAADADPDHDVPFPFSLSSAALF A_0025_068 MRTSGRLLLLCLAVGLLLESQAHP-----IADAGDATRNVGSDGTSVELSKMIDRGQDWSAEKGQRQASDNGHDKSMLRAADADPDHDVPFPFSLSSATLF A_0239_114 MRTSGRLLLLCLAVGLLLESQAHP-----IADAGDATRNVGSDGTSVELSKMIDRGQDWSAEKGQRQASDNGHDKSMLRATDADPDHDIPFPFSLSSATLF [Superfamily H-2b] [No Framework] [ /-----Signal---------/----------------------Pro---------------/ /-------------------------] V_CG13_195 MRTSSQLLFLCVSMGLVLALLGHP-----IADVRDAAEGADSEGRSMEGSQTIEGKEASSSDR RALNCETPTGEC--------------- V_1302_122 MRTSSQLLFLCVSMGLVLALLGHP-----IADVRDAAGGADSEGRSMEGSQTIEGKEASSSDR RALNCETPTGEC--------------- V_1278_100 MRTSSQLLFLCVSMGLVLALLGHP-----IADVRDAAEGADSEGRSMEGSQTIEGKEASSSDR RALNCESPTGEC--------------- A_0885_003 MRTSSQLLFLCVSMGLVLALLGHP-----IADVRD----ADSEERSMEGSQTIEGKEASSSDR RALNCGTPSGEC--------------- A_0875_075 MRTSSQLLFLCVSMGLVLALLGHP-----IADVRDAAEGADSEERSMEGSQTIEGKEASSSDR -Q-NCGTPSGEC--------------- A_0055_203 MRTSSQLLFLCVSMGLVLALLGHP-----IADVRDAARGADSEERSMEGSQTIEGKEASSSDR RQ-NCGTPTGEC--------------- A_0039_032 MRTSSQLLFLCVSMGLVLALLGHP-----IADVRDAAEGADSEERSMEGSQTIEGKEASSSDR -Q-NCGTPSGEC--------------- V_1302_123 MRTSSQLLFLCVSMGLVLALLGHP-----IADVRDAAGGADSEGRSMEGSQTIEGRQASLSES DGRKAQTFPSTKECNDIRC-------- V_1258_052 MRTSSQLLFLCVSMGLVLALLGHP-----IADVRDAAGGADSEGRSMEGSQTIEGRQASLSES DGRKAQTFPSTKECNDIRC-------- A_0520_189 MRTSSQLLFLCVSMGLVLALLGHP-----IADVRDAAEGADSEERSVEGSQTIEGKEASSSDR RQ-NCESPSGEC--------------- A_0025_353 MRTSSQLLFLCVSMGLVLALLGHP-----IADVRDAAGGADSEERSMEGSQTIEGKEASSSDR RALNCGSPSGAC--------------- A_0031_250 MRTSSQLLFLCVSMGLVLALLGHP-----IADVRDAPEGADSEGRSMEGSQTIEGKEASSSDR RALNCESPSGAC--------------- A_0025_352 MRTSSQLLFLCVSMGLVLALLGHP-----IADVRD----ADSEERSMEGSQTIEGKEASSSDR RALNCGSPSGAC--------------- A_0239_410 MRTSSQLLFLCVSMGLVLALLGHP-----IADVRDAAEGADSEGRSMEGSQTIEGKETSSSDR RALNCESP------------------- A_1387_010 MRTSSQLLFLCVSMGLVLALLGHP-----IADVRDAAEGADSEGRSMEGSQTIEGKEASSSDR RARNC---------------------- A_0048_048 MRTSSQLLFLCVSMGLVLALLGHP-----IADVRDAAEGADSEERSMEGSQTIEGKEA----- --------------------------- A_0239_411 MRTSSQLLFLCVSMGLVLALLGHP-----IADVRDAAEGADSEGRSMEGSQTIEGRQALSSEG RDHNFERTVTFSSDGTNHIPKLHWSEH K_0010_023 MRTSSQLLFLCVSMGLVFALLGHP-----IADVRDAARGAGPEGGSMERSQTIEGRQASSSEK RDKNC---------------------- [Superfamily I1-1] [Framework XI] [ /----------Signal-------------------/--------Pro-----------/ /--C-------C-----CC---CC-------C-------C----] A_0855_013 -----------MKLALIFLL----------ILPLMTGEKKSGDHERRSVKSLRAVFRDRR QFGCS-EAGETCKTYSSCCSRFCCEGSLGKRCA---RLSCDDIGV A_0055_009 -----------MKLALIFLL----------ILPLMTGEKKSGDHERRSVKSLRAVFRDRR QFGCS-EAGETCKTYSSCCSRFCCEGSLGKRCA---RLSCDDIGV A_0885_033 -----------MKLALIFLL----------ILPLMTGKIKSGDHERRSVESLRAVFRDRR QFGCS-EAGETCKTYSSCCSRFCCEGSLGKRCA---RLSCDDIGV A_0039_169 -----------MKLALIFLL----------ILPLMTGEKKSGDHERRSVKSLRAVFRDRR QFSCS-EAGETCKTYSSCCSRLCCEGSLGKRCA---RLSCDDIHI A_0039_165 -----------MKLALTFLLI-------LMILPLMTGEIKSGDHERRSVKSLRAVFRDRR QFSCS-EAGETCKTYSSCCSRLCCEGSLGKRCA---RLSCDDIHI A_0039_167 -----------MKLALTFLLI-------LMILPLMTEEIKSGDHERRSVKSLRAVFRDRR QFSCS-EAGETCKTYSSCCSRLCCEGSLGKRCA---RLSCDDIHI V_CG13_054 -----------MKLALTFLLI-------LMILPLMTGEKKSGDHERRSVKSLRAVFRDRR QFDCS-EAGETCMNYSSCCSRFCCEGSLGKRCA---RLSCDDIGV V_1302_121 ------------------LLI-------LMILPLMTGEKKSGDHERRSVKSLRAVFRDRR QFGCS-EAGETCMNYSSCCSRFCCEGSLGKRCA---RLNCDDIDI V_1258_040 ------------------LLI-------LMILPLMTGEKKSGDHERRSVKSLRAVFRDRR QFGCS-EAGETCMNYSSCCSRFCCEGSLGKRCA---RLNCDDIDI V_1278_027 ---------------------------------------------RRSVKSLRAVFRYHR QFSCS-EAGETCMTYSSCCSRFCCEGSLGKRCA---RLSCDDIGV A_0875_128 ----------------------------------------------------RAVFRDHR QFGCS-EAGETCMTYSSCCSQFCCKGSLGKRCA---RLNCDDIGV A_0855_014 ----------------------------------------------------------HR QFGCS-EAGETCKTYSSCCSRFCCEGSLGKRCA---RLSCDDIGV A_1387_047 -----------MKLALTFLLI-------LMILPLMTGEKKSGDHERRSVKSLRAVFRDRR QFGCS-EAGETCKTYSSCCSRLCCERSLGKRCA---RLSCDDIHI A_0239_288 -----------MKLALIFLLI-------LMILPLMTGEKKSGDHERRSVESLIAVFRDRR QFSCS-EAGETCKTYSSCCSRFCCEGSFGKRCA---RLRCDDIGV A_0031_321 -----------MKLALTFLLI-------LMILPLMTGEKKSGDHERRSVESLIAIFRDRR QFSCS-EAGETCKTYSSCCSRFCCEGSLGKRCA---RLSCDDIGV A_0520_205 -----------------------------------------------------ALLKGDW QFGCS-EAGETCKTYSSCCSRFCCEGSLGKRCA---RLSCDDIGV A_0239_289 -----------------------------------------GHYEAGSDISSDSAL-DDW QFGCS-EAGETCKTYSSCCSRFCCEGSFGKRCA---RLRCDDIGV ermineusAXL95521 -----------MKLALIFLL----------ILPLMTGKKKSGDHERRSVKSLRAVFRDRR QFGCS-EAGETCKTYSSCCSRFCCEGSLGKRCA---RLSCDDIGV A_0885_303 -----------MKLALTFLLI-------LMILPLMTGEIKSGDHERRSVKSLRAVFHDHR QFDCV-DGSETCQVNSNCCS------------------------- V_CG13_053 -----------MKLALTTLLV-------LMILPLMTGEKKSGDRERRSVKSLRTAFRDHR QFDCV-DGSETCQVNSNCCSYLCCQKTTGKRCAFKRTIGCEDIRI V_1302_119 -----------MKLALTTLLV-------LMILPLMTGEKKSGDRERRSVKSLRTAFRDHR QFDCV-DGSETCQVNSNCCSYLCCQKTTGKRCAFKRTIGCEDIRI V_1258_042 -----------MKLALTTLLV-------LMILPLMTGEKKSGDRERRSVKSLRTAFRDHR QFDCV-DGSETCQVNSNCCSYLCCQKTTGKRCAFKPTIGCEDIRI V_1278_028 -----------MKLALTTLLV-------LMILPLMTGEKKSGDRERRSVKSLRTAFRDHR QFKCG-DGSETCQVNSNCCSYLCCQKTTGKRCAFILTIGCEDVRI V_1302_118 -----------MKLALTFLLI-------LMILPLMTGEKKSGDHERRSVKSLRAVFRYHR QFECG-DGSETCRVNSNCCSYLCCQKTTGKRCAFKRTIGCEDIRI V_1258_041 -----------MKLALTTLLI-------LMILPLMTGEKKSGDHERRSVKSLRAVFRYHR QFECG-DGSETCRVNSNCCSYLCCQKTTGKRCAFKPTIGCEDIRI A_0885_032 -----------MKLALTTLLV-------LMILPLMTGEKKSGDRERRSVKSLRAVFHDHR QFDCV-DGSETCQVNSNCCSFLCCQKSTGKRCAFRGKPTCDDVNI A_0039_166 -----------MKLALTTLLV-------LMILPLMTGEKKSGDRERRSVKSLRAVFHDHR QFDCV-DGSETCQVNSNCCSFLCCQKLTGKRCAFRGKPTCDDVNI A_1387_048 -----------MKLALTTLLV-------LMILPLMTGEKKSGDRERRSVKSLRAVFHDHR QFDCV-DGSETCQVNSNCCSFLCCQKSTGKRCAFRGKPTCDDVNI A_0239_286 -----------MKLALTTLLV-------LMILPLMTGEKKSGDRERRSVKSLRAVFHDHR QFDCV-DGSETCQVNSNCCSFLCCQKSTGKLCAFRGKLTCDDVNI A_0031_320 -----------MKLALTTLLV-------LMILPLMTGEKKSGDRERRSVKSLRAVFHDHR QFDCV-DGSETCQVNNNCCSFLCCQKSTGKLCAFRGKLTCDDVNI A_0048_148 -----------MKLALTTLLV-------LMILPLMTGEKKSGDRERRSVKSLRAVFRDHR QFDCV-DGSETCQVNSNCCGFLCCQKSTGKRCAFRGKPTCDDVNI A_0055_008 -----------MKLA---LIF-------LLILPLMTGEKKSGDRERRSVKSLRAVFHDHR QFDCV-DGSETCQVNSNCCSFLCCQKSTGKRCAFRGKLTCDDVNI A_0025_432 -----------MKLA---LIF-------LLILPLMTGEKKSGDRERRSVKSLRAVFRDHR QFDCV-DGSETCQVNSNCCSFLCCQKSTGKRCAFRGKSTCDDVNI ermineusAXL95760 -----------MKLALTFLLV-------LMILPLMTGQKKSGDHERRSVKSLRAAFRGHR QFECI-EGGENCMVDSNCCSYLCCRKTTGRRCAFKRTVGCDDIRI betulinusAMP44653 -----------MKLAPTCLLV-------LMVLPLMTGEKKSGGHQRRSVKSMRALFRGHR QFECV-EGGENCLVYNQCCSLTCCQTSTGKQCAADQSVGCDS-DI [Superfamily I1-2] [Framework XI] [ /--------------Signal---------------/--Pro---/ /----------------C-------C-----CC---CC----C--------C------] A_0855_098 ---------------------------------RGGGEKSS---ER TLVGAL---LKGDWG-ACS-NIGEGCRHHHDCCGDMCCYDHTCGMTVLA--CDHFPF-- A_0855_099 ---------------------------------SSRGEKSS---ER TLVGAL---LKGDWG-ACS-NIGEGCRHHHDCCGDMCCYDHTCGMTVLA--CDHFPF-- V_CG13_057 ---------------------------------------------- ---------------------IGEGCNHHHDCFGDMCCYDHTCGVTVLA--CDHVPF-- A_0055_021 ---------------------------------------------- ---------------------IGEGCNHHHDCFGDMCCYDHTCGVTVLA--CDYVPF-- A_0875_039 ---------------------------------AGKGEKSS---ER TLIGAL---LKGDWG-AWS-NIGEGCNHHHDCFGDMCCYDHTCGMTVLA--CYHFPF-- A_0875_040 ---------------------------------SSRGEKSS---ER TLIGAL---LKGDWG-AWS-NIGEGCNHHHDCFGDMCCYDHTCGMTVLA--CYHFPF-- A_0875_041 ---------------------------------PVLGEKSS---ER TLIGAL---LKGDWG-AWS-NIGEGCNHHHDCFGDMCCYDHTCGMTVLA--CYHFPF-- A_0039_092 ---------------------------------KAIGEKSS---ER TLIGAL---LKGDWG-AWS-NIGEGCNHHHDCFGDMCCYDHTCGMTVLA--CYHFSF-- A_0039_168 ---------------------------------------------- --------------------------NHHHDCFGDMCCYDHTCGVTVLA--CDYVPF-- V_CG13_055 -----------MKLCVTFLLI-------LVILPSVTGEKSS---ER TLIGAL---LKGDWG-TCS-PIGQRCRHNYDCCGDMCCYGRTCVVTVAA--CIHFPF-- V_1278_102 -----------MKLCVTFLLI-------LVILPSVTGEKSS---ER TLIGAL---LKGDWG-TCS-PIGQRCRHNYDCCGDMCCYGRTCVVAVAA--YIHFPF-- A_0885_030 ---------------------------------------------- ------------DWG-TCS-HIGEGCRHHYHCCGDMCCYGRTCGVTVAA--CIHFPF-- A_0885_031 ---------------------------------------------- ------------SRG-TCS-HIGEGCRHHYHCCGDMCCYGRTCGVTVAA--CIHFPF-- A_0055_023 --------------------------------------------ER TLIGA----LKGYWG-TCS-HIGEGCRHHYQCCGDMCCYGRTCVVTVAA--CTHFSF-- A_0039_093 ---------------------------------------------- ------------HRG-TCS-HIGEGCRHHYQCCGDMCCYGRTCGVTVAA--CTHFSF-- A_0055_022 -----------MKLCVTFLLI-------LVILPSVTGEKSS---ER TLIGAV---LKGNWG-TCS-YVGEGCRHHYQCCGDMCCYSRTCGVTVAA--CIHFPF-- V_1302_117 -----------MKLCVTFLLI-------LVILPSVTGEKSS---ER TLIGAL---LKGDRG-ACS-PIGKGCSHHFHCCGDMCCNGHTCVVTVAA--CIHFRF-- V_1258_034 -----------MKLCVTFLLI-------LVILPSVTGEKSS---ER TLIGAL---LKGDRG-ACS-PIGTGCSHHFHCCGDMCCNGHTCVVTVPA--CIHFPF-- A_1387_205 -----------MKLCVTFLLI-------LVILPSVTGEKSS---ER TLIGAL---LKGDRG-TCS-HIGEGCRHHYHCCGDMCCYGRTCGVTVAA--CIHFPF-- A_0239_260 ---------------------------------------------- ------------DWG-TCS-HIGEGCRHHYHCCGDMCCYGRTCGVTVAA--CIHFPF-- A_0239_262 -----------MKLCVTFLLI-------LVILPSVTGEKSS---ER TLIGA----LKGYWG-TCS-HIGEGCRHHYHCCGDMCCYGRTCGVTVAA--CIHFPF-- A_0520_206 ------------------------------------GEKSS---ER TLIGAL---LKGDWG-TCS-HIGEGCRHHYQCCGDMCCYGRTCVVTVAA--CTHFSF-- A_0048_145 ------------------------------------GEKSS---ER TLIGAL---LKGDWG-TCS-HIGEGCRHHYQCCGDMCCYGRTCVVTVAA--CTHFSF-- A_0048_146 ------------------------------------GEKSS---ER TLIGAL---LKGDWG-AWS-NIGEGCNHHHDCFGDMCCCDHTCGMTVLA--CDHFPF-- A_0239_261 -----------MKLCVTFLLI-------LVILPSVTGEKSS---ER TLIGA----LKGYWG-AWS-HIGEGRNHHHDCCGDMCCYDHTCGVTVLA--CDHVPF-- A_0520_204 ---------------------------------------------- ---------------------IGEGCNHHHDCFGDMCCYDHTCGVTVLA--CDYVPF-- A_0239_263 ---------------------------------------------- ---------------------IGEGCNHHHDCFGDMCCYDHTCGVTVLA--CDHVPF-- A_0031_137 -----------MKLCVTFLLI-------LVILPSVTGEKSS---ER TLIGAL---LKGDWG-AWS-QIGEGCNHHHDCFGDMCCFFHTCVVTVMA--CDHVPF-- K_0010_047 -----------MKLCVTFLLF-------LVILPSVTGEKSS---ER KLSGAT---LRGYRG-KCS-RLGHGCKHHFHCCGNLCCFGRMCTATAMM--CEYFSV-- magusDAC80562 -----------MKLCVTFLLI-------LVILPSVTGKKSS---EH TPSDAA---LRGERG-TCS-PIGQQCIDHDDCCGTMCCMGGNCGVPVYILPCHFNS--- episcopatusBAS22221 -----------MKLCVTFLLI-------LVILPSVTGEKSS---KR TLSGAA---LRGDWG-MCS-GIGQGCGQDSNCCGDMCCYGQICAMTFAA--CGPYFFPF [Superfamily I1-1,2; pro of I1-1 & mature of I1-2] [Framework XI] [ /------------Signal-----------------/----------Pro---------/ /--C-------C-----CC---CC----C------C----] A_0875_126 -----------MKLALTFLLI-------LMILLLMTGEIKSGDHERRSVKSLRAVFRDHR E-TCS-DT--GCSHHYHCCGDMCCYSRTCVVTVAACTHFSF A_0885_029 -----------MKLALTFLLI-------LMILPLMTGEIKSGDHERRSVESLRAVFRDHR E-TCS-HIGQGCGHGHHCCGDMCCYSRTCVVTAAVCTHFSF A_0875_127 -----------MKLALTFLLI-------LMILLLMTGEIKSGDHERRSVKSLRAVFRDHR E-TCS-HIGQGCGHGHHCCGDMCCYSRTCVVTAAVCTNFSF A_0048_147 -----------MKLALIFLL----------ILPLMTGEIKSGDHERRSVKSLRAVFRDHR G-TCS-HIGEGCRHHYQCCGDMCCYGRTCVVTVAACTHFSF imperialisADZ74137 -----------MKLALTFLLI-------LMILPLMTGEKTSGDHELRGVDSLKAILRDRR ---CSDDTGATCSDNSDCCGDMCCLSNTCVVTIVACS---- [Superfamily I2-1] [Framework XI] [ /---------Signal-----------//C--------C-----CC---CC----C---C---/-------Post-------] A_0855_100 MMFRVTSVGCFLLVIIFLNL--VVLTNA C-KLN-GMDCETYNQCCGSVCCRG-TCAHPCRV-VGKRAKLQEFFRQR------ V_CG13_152 MMFRVTSVGCFLLVIVFLNL--VVLTNA C-NHD-GKDCERNNECCESVCCLG-TCAKLCRI-VGKRAKLQEFFRQR------ V_1302_006 -------VGCFLLVIVFLNL--VVLTNA C-IHD-GKDCERHNECCESVCCSG-TCAKPCRI-VGKRAKLQEFFRQR------ V_1258_007 -------VGCFLLVIVFLNL--VVLTNA C-IHD-GKDCERHNECCESVCCSG-TCAKPCRI-VGKRAKLQEFFRQR------ A_0885_002 MMFRVTSVGCFLLVIIFLNL--VVLTNA C-KLD-GTYCERYNQCCGSVCCRG-TCANPCRI-VGKRAKLQEFFRQR------ A_0055_205 MMFRVTSVGCFLLVIIFLNL--VVLTNA C-ILD-GTDCEKHNQCCDSVCCFG-TCANPCRV-VGKRAKLQEFFRQR------ A_0055_206 MMFRVTSVGCFLLVIIFLNL--VVLTNA C-KFD-GMYCERYNQCCGFVCCRG-TCANPCRN-VGKRAKLQEFFRQR------ A_0039_026 MMFRVTSVGCFLLVIIFLNL--VVLTNA C-KFD-GMYCERYNQCCGFVCCRG-TCANPCRN-VGKRAKLQEFFRQR------ A_0520_303 MMFRVTSVGCFLLVIIFLNLFQVVLTNA C-KLD-GTFCERNDQCCDSVCCRG-TCANPCRN-VGKRAKLQEFFRQR------ A_0239_072 MMFRVTSVGCFLLVIIFLNL--VVLTNA C-ILD-GTDCEKHNQCCDSVCCFG-TCANPCRV-VGKRAKLQEFFRQL------ A_0031_057 MMFRVTSVGCFLLVIIFLNL--VVLTNA C-ILD-GKDCERNNQCCNSVCCFG-TCTYPCRN-IGKRAKVQEFFRQR------ A_0025_097 MMFRVTSVGCFLLVIIFLNL--VVLTNA C-KLD-EMSCRRHSQCCGAVCCSG-TCAKPCRI-VRKRAKLQEFFRQR------ A_0025_095 MMFRVTSVGCFLLVIIFLNL--VVLTNT C-KLD-ELSCRRHSQ--------------------------------------- A_1387_049 MMFRVTSVGCFLLVIIFLNL--VVLTNA C-ELD-GTNCGSHYDCCEGTCCFG-TCANPCRI-VGKRAKLQEFFRQR------ A_0520_304 MMFRVTSVGCFLLVIIFLNL--VVLTNA C-KID-GAYCGSHYDCCEGTCCFG-TCANPCRN-VGKRAKLQEFFRQR------ A_0025_096 MMFRVTSVGCFLLVIIFLNL--VVLTNA C-KIE-GAYCENHYECCEGPCCFG-VCMNPCRI-VRKRAKLQEFFRQR------ K_0010_374 -MFRLTSVGCFLLVIVFLNL--VVLTNA C-YPE-GTFCQYHFTCCXXXCCWG-SCENPCRY-PGTRAKLQEFFRQR------ ermineusAXL95465 MLFRVTSVGCFLLVIIFLNL--VVLTNA C-KLD-EMSCRRHSQCCGAVCCSG-TCAKPCRI-VGKRAKLQEFFRQR------ episcopatusBAS22304 -MVRVTSVGCFLLVILSLNL--VVLTNA C-LSE-GSPCSMSGSCCHKSCCRS-TCTFPCRI-PGKRAKLREFFRQR------ betulinusAAF23167 MMFRVTSVGCLLLVIVFLNL--VVPTSA C-RAE-GTYCENDSQCCLNECCWG-GCGHPCRH-PGKRSKLQEFFRQR------ striolatusP0C258 MMFRVTSVGCLLLVIVFLNL--VVPTSA C-RAE-GTYCENDSQCCLNECCWG-GCGHPCRH-PGKRSKLQEFFRQR------ spuriusACY01953 MMFRVTSVGCFLLVIVFLNL--VVLTNA C-RTE-GMSCEENQQCCWRSCCRG-ECEAPCRFGPGKRAQLQEFFQHR----- gloriamarisGFNK01000018 -MVRVTSVGCFLLVIVFLNL--VGRTNA C-IAE-GSSCSNGGRCCSNSCCFGTTCRLPCII-PGKRAKLLEFFRQR------ betulinusAMP44661 -MFRVTSVSCFLLVIVLLNL--VVLTDA C-HHE-GLPCSSDDGCCGMECCNG-VCSSSCGN-GRRRQVPLKSFGQRRYV--- ermineusAXL95585 -MFRLTSVGCFLLAIVLLNL--VVLTDA CHHHE-GSLCLKDGDCCGMRCCFW-RCSSQCPI-PWLRQVPLNLFGQR------ andremeneziATF27393 MMFRLTTVSCFLLVIVLLNL--VVLTDA C-YYDVGDPCSSNEECCISECCYG-ICLQWCTW-PVYKRGRRHVSFKVFGQR-- praecelensATF27601 MMFRLTTVSCFLLVIVLLNL--VVLTDA C-YYDVGDPCSSNEECCISECCYG-TCLQWCHW-PVYKRGRRHVSFKVFGQR-- [Superfamily I2-2] [Framework XI] [ /--------Signal-------/ /---C------C-----CC-----CC--------C-----C-----------------/P] K_0010_056 MMCRLTSLCCLLVIVLLNSAVDG IP--CNGPGEWCSTHMWCCVSSDVCCDVP-GTAVCTRGSACSWPTI-PQGRRALYTRFFRR V_1258_001 MMCRLTSLCCLLVIVLLNSAVDG IP--CHGTGGWCSTHMWCCDSRDVCCDVP-GTAVCTRESACSWPTI-PQGRRALYTRFFRR V_CG13_199 MMCRLTSLCCLLVIVLLNSAVDG IP--CHQTGGWCSTHMWCCDSLDVCCDFP-SGATCAKESACSWPIIHPTGRRAL------- ermienusAXL95698 MMCRLTSLCYLLVIVLLNSAVDG IP--CRGPGGWCSTLMWCCAPRDVCCGIP-GFAVCRRESECPWPRI-PQGPH--------- magusMN517334 MMCRLTSLCSLLVIVFLNSAAGG IP--CVGSGGFCSPHVWCCDSLDVCCELP-------------------------------- betulinusAMP44659 MMCRLMSLCCLLLIVSLDLAVGG IP--CNQPGGWCSSHMWCCDSSDVCCEFP-GSAMCTSESACESAHF-APGRRAQYTRFFRR eburneusC7DQB9 MMFRLTSVWCLLVIVLLNSAVDG IP--CTGSEGYCHSHMWCCNSFDVCCELP-GPATCTREEACETLRI-ALGRRAQYKRFFRR milesAKB91381 MMCRLTSLCCLLVIVLLNSAVDG VP--CQQGGGKCSSDLKCCDGRDVCCGTS-GSATCTIESECSGERI-THTHRALHARFFRR A_1387_365 MMCRLTSLCCLLVIVVLNSAEDG VPVTCITTGELCLPGL-CCNP-QVCCSSEEYWLTCVDKSVCDKSLL-KDARH-KYTRFFRR [Superfamily I3] [Framework XI] [ /------Signal-----/-----------------Pro-------//C------C-----CC---CC------C------C/--P] V_CG13_020 MKLSLAIVLILMLLHLSTGAETSDNHASRSATALRDRLLLSK----R CQDRYESCWKDSQCCGELCCTGPS-YCDYSIGRCKFVK V_1258_025 MKLSLAIVLILMLLHLSTGAETSDNHASRSATALRDRLLLSK----R CQDKYESCWKDSQCCGELCCTGPS-YCDDSIGRCKFGK V_1302_054 MKLSLAIVLILMLLHLSTGAETSDNHASRSATALRDRLLLSK----R CQDKYESCWKDSQCCGELCCIGSS-YCDDSIGRCKFGK A_0055_219 MKLSLAIVLILMLLHLSTGAETSGNRASRSGTALRDRLLLSK----R CQDKYESCWKDSQCCGELCCTGPS-YCDDSIGRCKFGK A_0039_060 MKLSLVIVLILMLLHLSTGAETSGNHASRSGTALKDRLLLSK----R CQGKYESCWKDSQCCGELCCTGPS-YCDYSIGRCKFGK K_0010_149 MKLFLAIALFLMLLSFSTGAQTSDNRASRSA--LRDRLLLSK----R CQNKYENCSNDSDCCEQLCCSGPS-YCDRSIGRCHFGK V_1258_026 MKLSLAIVLILMLLHLSTGAETSDNHASRSATALRDRLLLSK----R CQNKYENCSNDPDCCGELCCTGPS-YCDDSIGRCKFGK V_1258_027 MKLSLAIVLILMLLHLSTGAETSDNHASRSATALRDRLLGPKA--SI CRGTGGRCSNDNHCCGWLCCG----------------- A_0239_285 -----------------------------------------R----R CQDKYESCWKDSQCCGELCCTGPS-YCDDSIGRCKFGK A_0239_284 MKLSLAIVLILMLLHLSTGAETSGNRASRSGTALRDRLLLSK----R CQDKYESCWKDSQCCGELCCTGPS-YCDDSIGRCKFGK A_0048_020 MKLSLAIVLILMLLHLSTGAKTSGNHASRSGTALRDRLLLSK----R CQDKYESCWKDSQCCGELCCTGLS-YCDNSIGRCKFGK A_0031_442 MKLSLVIVLILMLLHLSTGAETSGNHASRSGTALKDRLLLSK----R CQGKYESCWKDSQCCGELCCTGPS-YCDYSIGRCKFGK A_1387_025 MKLSLAIVLILILLHLNTGAETSGNHASRSGTALRDRLLLSK----R CQERHKSCWKDSQCCGELCCTGPS-YCDYSIGKCKFGK K_0010_148 MKLFLAIALFLMLLSFSTGVETSDNRASRRATALRDSGLGPKA---- -------------------------------------- K_0010_150 MKLFLAIALFLMLLSFSTGVETSDNRASRSATALRDRLLGPKA--SI CRRMGGICSHHYHCCGGLCCLGMSGGCIVAFLPCY--- ermineusAXL95386 MKLFLAIVLILMLLSLSTGAETSDNHASRSATALRDRLLGPKA--LT CRVRGERCTDDNDCCGWFCCAG---ACFFTFLPCK--- ermineus AXL95629 MKLSLAIVLILMLLSLSTGAETSDNHASRSATALRDRLLGPKT--WS CQWQGETCSHHHDCCGSLCCAG---SCVMTIIPCK--- betulinusAMP44662 MKLSLAIVLILMLLSLSTGAETSDNRASGSTTALRDRLLGPKAWIWM CQGKGERCSDDDDCCGWLCCVG---VCSMSVVGCK--- caracteristicusD2DGD4 MKLVLAIVVILMLLSLSTGAEMSDNHASMSANALRDRLLGPKA--LL CGGTHARCNRDNDCCGSLCCFG---TCISAFVPC---- geographusBAO65650 MKLFLAIVLILMLQFLSTGAETSDNHASRSTTALRDWLLGPKA--KR CAVTHEKCSDDYDCCGSLCCVG---ICAKTIAPCK--- andremeneziATF27402.1 MKLFLAIVLILMLLSLSTGAETSDNHASRSTIALRDRLLHPNRQ-WG CRRRYRRCSHDNDCCGSLCCAR---VCTLMYAPCL--- praecellensATF27605.1 -KLFLAIVLILMLLSLSTGAETSDNHASSSTTALRDRLLHPNRQ-WG CRRRYRRCSHDNDCCGPLCCAR---VCTLMYAPCL--- [Superfamily I4] [Framework XII] [ /----------Signal----------C//C--------C-------C-C----CC----------C-----C-----------------/----Post------] V_CG13_062 ---MFGHTSVRFLLLSIMLMGMAAMVLC SCFTQL-GETCEQ--EETCTCSNQRCCHTTSSVTKDQCMTEYHCYWWRPDDY--KRRAIQRQKRFLGLVRGLDS--- V_CG13_063 ---MFGHTSVRFLLLSIMLMGMAAMVLC TCNSRF-GETCEH--EEFCSCPHHGCCHTTSSVTKDQCMTQDVCTAWVSDNS--KRRAIQRQKGFLGMVRGLDS--- V_1302_074 ---MFGHTSVRFLLLSIMLLGMAAMVLC TCNSRF-GETCEH--EEFCSCPHHGCCHTTSSVKKNQCMTQDVCTAWVSDNS--KRRAIQRQKRFLGLVRGLDS--- V_1302_075 ---MFGHTSVRFLLLSIMLLGMAAMVLC SCFTQL-GETCEQ--EETCTCSNQRCCHTTSSVTKDQCMTEYHCYWWRPDDY--KRRAIQRQKRFLGLVRGLDS--- V_1258_044 ---MFGHTSVRFLLLSIMLLGMAAMVLC TCNSRF-GETCEH--EEFCSCPHHGCCHTTSSVKKNQCMTQDVCTAWVSDNS--KRRAIQRQKRFLGMVRGLDS--- V_1258_045 ---MFGHTSVRFLLLSIMLLGMAAMVLC SCFTQL-GETCEQ--EETCTCSNQRCCHTTSSVTKDQCMTEYHCYWWRPDDY--KRRAIQRQKRFLGMVRGLDS--- A_0885_049 ---MFGHTSARFLLLSIMLLGMAAMVLC TCDSRF-GETCEH--GEICSCPHHGCCHATSSVKKNQCMTQGACRAWVSGNG--LRRAIHRQKIFLGMVRGLDS--- A_0875_046 ---MFGHTSARFLLLSIMLLGMAAMVLC TCDSRF-GETCEH--EEICSCPHHGCCHATSPVKKNQCMTQGACRAWVSGNS--LRRAIQRQKRFLGMVRGLDS--- A_0055_201 ---MFGHTSVRFLLLSIMLLGMAAMVLC TCDSRF-GETCEH--EEICSCPHHGCCHATSSVKKNQCMTQGACRAWVSGNS--LRRAIQR---------------- A_0055_202 ---MFGHTSVRFLLLSIMLLGMAAMVLC TCDSSF-GETCEQ--EETCSCSNHRCCHTTSSVTKDQCMTGRKCFWWDPVRS--KRRAIQRQKRFLGRVRGLDS--- A_1387_199 ---MFGHTSVRFLLLSIMLLGMAAMVLC TCNSSF-GETCEQ--EEICSCSNHRCCHTTSSVTKDQCMTEYQCYWWKPEYS--KRRAIQRQKRFLGMVRGLDS--- A_0048_183 ---MFGHTSVRFLLLSIMLLGMAAMVLC TCDSSF-GETCEL--WQTCSCSNHWCCQTTSSVTKDQCMTEFSCEWWQPYRR--KRRAIQRQNRFLGMVRGLDS--- A_0239_149 ---MFGHTSARFLLLSIMLLGMAAMVLC TCDSRF-GETCEH--EEICSCRHHGCCHSTSSVKKNQCMTQGACTVWVSENS--KRRAIQRQKRFLGMVRGLDS--- A_0031_012 ---------------------------- -----------------ICSCPHHGCCHATSSVKKNQCMTQGACTVWVSENS--KRRAIQRQKRFLGMVRGLDS--- A_0025_229 ---MFGHTSARFLLLSIMLLGMAAMVLC TCNYSF-GETCE----QICSCSNHVCCSTTSPVKKNQCMTPSTCMTWAIGNG--KRRAIQRQKRFLGMVRGLDS--- A_0520_175 ---MFGHTSARFLLLSIMLLGMAAMVLC TCDSRF-GETCEH--GEICSCPHHGCCHTTSSVKKNQCMTQGACRAWVSGNS--LRRATQRLKRFLGMVRGLDS--- ermineusAXL95489 ---MFGHTSARFLLLSIMLLGMAAMVLC TCNYSF-GETCE----QICSCSNHVCCSTTSPVKKNQCMTPSTCMTWAIGNG--KRRAIQRQKRFLGMVRGLDS--- A_0855_032 ---MSGHTSISFLLLSIVVLGMVATVIC SCEEMFSSEHCEEPGHEICSCSNHVCCHL-NNVKRDQCMTAAMCHAASGGNG--RRRSTQMQERFLRMKRGLAD--- A_0855_033 ---MSGHTSVRFLLLSIMVLGMVATVIC SCEERISSEHCEEPGHEICSCSNHVCCHS-SSAKRDRCMTQAMCHAASGGNG--RRRSTQMQERFLRMKRGLAD--- V_1302_076 ---MSGHTSVSFLLLSIMVLGMVATVIC SCDDSISSEHCEEPGHEICSCSNHVCCHL-GNAKRDQCMTQANCYMAISGNG--RRRSTQMQERFLRMPRGLAD--- V_1302_077 ---MSGHTSVSFLLLSIMVLGMVATVIC SCEEKISSEHCGEPGHEICSCSNHVCCHL-GDVKRDQCMTQDMCRMASSGNG--GRRSTQMQEGFLRMLRGLAD--- V_1258_158 ---------------------------- -------------------------CCHL-GNAKRDQCMTQANCYMAISGNG--RRRSTQMQERFLRMPRGLAD--- A_0885_048 ---MSGHTSVRFLLLSIMVLGMVATVFC SCEEKISSEHCEEPGHEICSCSNHVCCHL-SSAKRDQCMTQGMCHSAVGGHG--RRRSTQMQERFLRMKRGLAD--- A_0875_047 ---MSGHTSVRFLLLSIMVLGMVATVIC SCEERISSEHCEEPGHEICSCSNHVCCHL-SSAKRDQCMTQAMCHAASGGNG--RRRSTQMQERFLRMKRGLAD--- A_0055_141 ---MSGHTSVSFLLLSIMVLGMVATVIC SCEEKISSELCEEPGNKICSCSNHVCCEL-GGAKSDQCMTLARCHAALVGNI--RRRSTQMQERFLRMKRPFAD--- A_0055_142 ---MSGHTSVSFLLLSIMVLGMVATVIC SCEERISSEHCEEQGQEICSCSNHICCHL-SKVKTDQCMTLAMCRAAGGGHG--GRRSTQMQERFLRMKRGLAD--- A_0039_090 ---MSGHTSVSFLLLSIVVLGMVATVIC SCGD-ISNDHCGEPG-QTCSCSSHVCCHL-GGAKRDQCMTQPMCRAVVVGNG--RRRSTQMQERFLRMKRPFADWSV A_0520_177 ---MSGHTSVSFLLLSIMVLGMVATVIC SCEERISSEHCEEPGHEICSCSNHVCCHL-SNVKRDQCMTLGMCHAAIGGHG--RRRSTQMQERFLRMKRGLAD--- A_0048_227 ---MSGHTSVSFLLLSIMVLGMVATVIC SCGETISSEHCEEPGHEICSCSNHMCCHL-SNAKRDQCMTPSMCHAASGGNG--RRRSTQMQERFLRMKRGLAD--- A_0239_425 ---MSGHTSVSFLLLSIMVLGMVATVIC SCEERISSEHCEEQGQEICSCSNHICCHL-SKVKTDQCMTLAMCRAAGGGHG--GRRSTQMQERFLRMKRGLAD--- A_0031_044 ---MSGHTSVSFLLLSIMVLGMVATVIC SCQERISSEHCGEPGHEICSCSNHVCCTL-SNAKRHKCMTQGMCHMTSGGNG--RRRSTQMQERFLRMKRGLAD--- A_0239_426 ---MSGHTSVSFLLLSIMVLGMVATVIC SCEEKISSELCEEPGNKICSCSNHVCCEL-GGAKSDQCMTLARCHAALVGNI--RRRSTQMQERFLRMKRPFAD--- A_1387_020 ---MSGHTSISFLLLSIVVLGMVATVIC SCGD-ISNDHCGKPG-QTCSCSSHVCCHL-GGAKRDQCMIQPMCQMAIVGNG--RRRSTQMQERFLRMKRPLAD--- A_0520_176 -------------------------VIC SC-QKVSSEYCEKQGPATCS-SNHMCCPL-SETKKPQCMEAAMCHMTSGGNG--RRRSTQMQERFLRMKRGLAD--- A_0025_191 -------------------------VIC SC-QKVSSKYCEKQGPATCS-SNHMCCHL-SETKKPQCMEAAMCHMTSGGNG--RRRSTQMQERFLRMKRGLAD--- A_0520_178 ---MSGHTSVSFLLLSIMVLGMVATV-- ------SSEYCEKQGPATCS-SNHMCCPL-SETKKPQCMEAAMCHMTSGGNG--RRRSTQMQERFLRMKRGLAD--- A_0025_190 ---MSGHTSVSFLLLSIMVLGMVATV-- ------SSKYCEKQGPATCS-SNHMCCHL-SETKKPQCMEAAMCHMTSGGNG--RRRSTQMQERFLRMKRGLAD--- K_0010_018 ---MFGHTSVSFLLLSIMVLGMVATVIC SCGDSISSEHCDQPGEEICSCTNHICCHL-SQAKRDQCMTQNRCLKAIGGNS--HRRSNRMQEKFLRMPRGLVG--- magusQFQ61018 ---MSGHTSVNFLLLSIVALGMVATVIC LCDSYISSELCEHP-EETCFCPNHMCCPL-SPYRQDQCM-------------------------------------- ermineusAXL95575.1 ---MSGHTSVRFLLLSIMVLGMVATVIC SCEERISSEHCEEPGHEICSCSNHVCCHS-SSAKRDRCMTQAMCHAASGGNG--RRRSTQMQERFLRMKRGLAD--- andremeneziATF27403 ---MFGHTSVRFLLLSIMLLGMVAMVWC SCGT-L-GEECEG--ETACRCSNHECCNMEPTPRKDQCMTQHACYIVHSGKR--RRRVIQKQKRFLGMPRGHAR--- eburneusACV13218 ---MFGHTSVSFLLLSIMALGMVATVIC SCDSEFSSEFCEQPEERICSCSTHVCCHL-SSSKRDQCMTWNRCLSAQTGN----RRSTHMQKRFLRMPRDLAD--- marmoreusACV13220 ---MFGHTSVSFLLLSIVALGMVATVIC SCDSEFSSEFCEQPEERICSCSTHVCCHL-SSSKRDQCMTWNRCLSAQTGN----RRSTHMQKRFLRMPRDLAD--- betulinusAMP44660 ---MFSHTSVSFPLFSIMVLGMVATVIC SCGSDISNEICEEPDKNGCSCPNHNCCIL-NPPKRDQCMTQHMCYILLSENR--RRRSTQMQERFLRMPRGLAD--- praecellensATF27608 ---MFGHTSVNFLLLSIMVFGMVATVIC SCGEIVSDESCEQPGEKICSCSNHVCCE--NPPYSDYCMTWRACYAITVGFGFSRRRAIQMQERFLRMTRGLAD--- gloriamarisGFNK01000024 ---MSGHTSVSFLLLSIVALGMVATVIC SCNPYISSETCEQP-EENCSCPNTSCCEL--YPRRNQCMSGEMCYIARLPPG--SRGLTRMQKRFLRMPRDLAD--- A_0875_068 -------------------------V-C PCND-Y-GQKCGP--NDSCECDSHVCCTL-SEAKPKQCMKNGSCRS---AHS--RRETIQRQDKFISALYGREEQ-- A_0055_200 MVKMFRPTCFSFLLLSILLLGMMSTV-C PCND-Y-GEKCGP--NDSCECDSHVCCTL-SGAKPKQCMTNGSCRS---AHS--RRETIQRQDKFISALYGREEQ-- V_1302_078 MVKMFHPTCFSFLLLSVLLLGMMSTV-C PCED-Y-GPKCGQ--NDFCECDNHVCCTL-SEAKSKQCMTGSSCRV---AQS--VREAIQTRDKFISALYGREEQ-- V_1258_165 MVKMFHPMCFSFLLLSVLLLGMMSTV-C PCED-Y-GPKCGQ--NDFCECDNHVCCTL-SEAKSKQCMTGSSCRV---AQS--VREAIQTRDKFISALYGR----- A_0031_326 ---------------------------- -----------------SCECGSHVCCTL-SGAKPKQCMTNARCRS---AQS--PRETIQRQDKFISALYGREEQ-- A_0520_038 MVKMFRPTCFSFLLLSVLLLGMMSTV-C PCND-Y-GQECVQ--SDSCKCG-HVCCTL-SEAKPKQCMTKTSCIS---AQS--PRETIQRQDKFISALYGREEQ-- ermineusAXL95396 MVKMFRPTYFSFLLLSVLLLGMMSMVVC DCSDNY-GLVCGE--NDSCECSRYICCPM-SNAKPKQCMTEGSCKH---ASD--RRETIQTRDEFISALYGREEQ-- [Superfamily J-1] [Framework XIV] [ /----------Signal-------/-----Pro------/ /---------C---C---------C-C-----------/--Post--] V_1302_137 -MASVQSVTCCCLLWLMLSVQLVNPGSPGTAP---HRTAR VPPESVLETICPEMCNEGIG-QPYCYCTKKR-DVVSSRIRRRQRSMAV V_1258_038 -MASVQSVTCCCLLWLMLSVQLVNPGSPGTAP---HRTAR VPPESVLETICPEMCNEGIG-QPYCYCTKKR-DVVSSRIRRRQRSMAV A_0885_006 -MTSVQSVTCCCLLWLMLSVQLVTPGSPGTAP---HCTAR VPAEPVLEIICPEICNEGVG-QPYCYCTKKR-DVVSSRIRRRQRSMAV V_1302_138 ----------------MLSVQLVTPGSPGTAQLSRHLSAR VPSEAHLEVLCPAMCDEGRR-GIFCTCAKK------------------ V_1302_139 -MTSVQSVTCCCLLWLMFSVQLVTP---------RGRTAR VPAEHILEIICPTMCHMGVG-EPFCNCPDKR-DVVSSLIRRRKRSMAV A_0855_001 -MTSVQSVTCCCLLWLMLSVQLVTP---------RGRTAR VPAEHILEIICPTMCHLGVG-EPFCNCPDKR-DVVSSRIRRRKRSMAV V_CG13_019 -MTSVQSVTCCCLLWLMLSVQLVTP---------RGRTAR VPAEHILEIICPTMCHMGVG-EPFCNCPDKR-DVVSSRIRRRKRSMAV V_1278_005 -MTSVQSVTCCCLLWLMFSVQLVTP---------RGRTAR VPAEIILEKICPTMCHMGVG-EPFCNCPDKR-DVVSSRIRRRKRSMAV A_0875_001 -MTSVQSVTCCCLLWLMLSVQLVTP---------RGRTAR VPAEHILEIICPTMCHLGVG-EPSCNCPDKR-DVVSSRIRRRKRSMAV A_0055_031 -MTSVQSVTCCCLLWLMLSVQLVTP---------RGRTAR VPAEHILDIICPTMCNLGVG-EPFCNCPDKR-DVVSSRIRRRKRSMAV A_0039_022 -MTSVQSVTCCCLLWLMLSVQLVTP---------RGRTAR VPAEHILDIICPTMCNLGVG-EPFCNCPDKR-DVVSSRIRRRKRSMAV A_0031_319 -MTSVQSVTCCCLLWLMLSVQLVTP---------RGRTAR VPAEHILEIICPTMCHLGVG-EPSCNCPDKR-DVVSSRIRRRKRSMAV A_0239_210 -MTSVQSVTCCCLLWLMLSVQLVTP---------RGRTAR VPAEHILEIICPTMCHMGVG-EPFCNCPDKR-DVVSSRIRRRKRSMAV A_1387_073 -MTSVQSVTCCCLLWLMLSVQLVTP---------RGRTAR VPPEHILEIICPTMCHTGVG-EPFCNCPDKR-DVVSSRIRRTKRSMAV A_0520_052 -MTSVQSVTCCCLLWLMLSVQLVTP---------RGRTAR VPAEHILEIICPDMCHEGGA-EPFCNCPDKR-DVVSSQIR---RAMAV A_0048_212 -MTSVQSVTCCCLLWLMLSVQLVTP---------RGRTAR VPAEHILEIICPDMCHEGGA-EPFCNCPDKR-DVVSSQIR---RAMAV A_0520_053 -MTSVQSVTCCCLLWLMLSVQLVTP---------RGRTAR VPAEHILEQICPSMCHKGVG-GPFCNCPDKR-DVVSSRIRRRKRSMAV A_0025_011 -MTSVQSVTCCCLLWLMLSVQLVTP---------RGRTAR DLGDHLINMLCPTICHKGNG-KDVCNCPYKR-DVVSSRIRRRKRSMAV K_0010_147 -MPSVQSVTCCCLLWLMLSVQLVTPGSPGTAQLPRDRTAR VPPPPILELICPDMCSRGIG-EPFCDCSDKR-D--------------- ermineusAXL95634 -MTSVQSVTCCCLLWLMLSVQLVTP---------RGRTAR VPPEHILEII-------------------------------------- marmoreusAGE10493 -MPSVRSVTCCCLLWMMFSVQLVNPGSPGTAQLSRHRTAR VPAEPILEIICPEMCDEGVG-EEPFCHCTEKRDAVSSRIRRRKRSTAV betulinusAGE10498 -MPSVRSVTCCCLLWMMFSVQLVTPGSPGTAQLPRDRTAR APAELILETICPHMCGTGIG-EPFCNCRNKR-DVVSSRIIRRKRSMAV marmoreusAGE10495 -MPSVRSVTCCCLLWMMFSVQLVNPGSPGTAQLSRHRTAR VPAEPILEIICPEMCDKGVGEEPFCHCTEKR-DAVSSRIRRRKRSTAV praecellensATF27614 -MTSVQSVTCCCLLWLMLSVQLVTPGSPGTAQLSGHRAAR VPPPEIMVVLCPGICRNDPT-SPLCDCSNIL-GVVT--VTR------- gloriamarisGFNK01000026 -MTSVQSVTCCCFLWLMLSVQLITPSPPGTAHLPRDGTDR DNPDDDENTVCYFLCLMGID-LDECNCPEKR-DLVSSLISR-KRSMAM geographusBAO65601 -MTSVQSVTCCCLLWLMLSVQPITPGSPGPAQLSRERSFK FLSGGFKEIVCHRYCAKGIA-KEFCNCPDKR-DVVSPRIRRRKRSKAM magusQFQ61020 -MTSVQSVTCCCLLWLMLSVQLVTPDSPATAQLSRHLTAR VPVGDPLQHTCSEWCNEGQD-VAVCTCAQRR-DVVSSSLRRRKRSMRL [Superfamily J-2] [Framework XIV] [ /----------Signal-------/------Pro-------/ /-------C---C--------C-C-----------/---Post---] V_CG13_035 -MPSVQSVTRCCLLLLLLSALCVCPLPLRISQPLPQQLNIER GIPKEFESCNVLCARLDPPARCNCPGTP---DVVEVK-KRTEVSMAP V_1302_034 -MPSVQSVTRCCLLLLLLSALCVCPLPLRISQPLPQQLNIER GIPKEFESCNVLCARLDPPARCNCPGTP---DVVEVK-KRTEVSMAP A_0239_080 -MPSVQSVTRCCLLLLLLSALCVSPLPLRISQPLPQQLNIER GIPKGLQSCNVLCARLDPPAKCNCPGTP---DVVEVK-KRTEVSMAP A_0025_245 MMPSVQSVTRCCLLLLLLSALCVSPLPLRISQPLPQQLNIER GIPKGLQSCNVLCARLDPPANCNCPGTP---DVVEVK-KRTEVSMAP A_1387_162 -MPSVQSVTRCCLLLLLLSGLCVCPLPFGISQPLPQQLNIER RIDEDFDGCVEGCLYPMPPASCNCQGTR---DVVDLK--RTELSMAP K_0010_014 -----QSVTRCCLLLLLLSALCGSPLPFGISQPLPQQLNIER GIPKGSKSCEELCIYPLPPANCNC----------------------- V_CG13_321 -MPSVQSVTRCCLLLLLLSALCVSPHPFGISQPLPQQLNIER ---EDFDPCNRLCAQGSPSDECRERVCPTPWDVIETRHKRTELSMAP [Superfamily K] [Framework XXIII] [ /------Signal------/ /-------------C------C---C-------------CC--------------C---] V_1258_029 MNMRMMLTLFVLVVMTTVSA SEH---EANRPDRDCGNTWEECYAWCKE-LPYIPSEMQNCCRFVNSIPRLEN-RDCADYD V_1258_030 MNMRMMLTLFVLVVMTTVSA SEH---EANRPKGVCGNTWEECYAWCKE-LPYIPSEMQNCCRFVNSIPRLEN-RDCADYD V_1302_027 MNMRMMLTLFVLVVMTTVSA SEH---EANRPKGVCGNTWEECYAWCEE-LPYIPSEMKNCCRFVNSIPRLEN-RDCADYD V_1302_028 MNMRMMLTLFVLVVMTTVSA SEH---EANRPNCACGNTWEECYAWCEE-LPYIPSEMKNCCRFVNSIPRLEN-RDCADYD A_0055_209 MNMRMMLALLVLVVMTTVSA SEHGLTEAKETK-QC-STSLGCFNWCRYWFYRLPIT--TCCELVQEIGFWPPVRYCS--- A_0039_033 MNMRMMLALLVLVVMTTVSA SEHGLTEAKETK-QC-STSLGCFNWCRYWFYRLPIT--TCCELVQEIGFWPPVRYCS--- V_CG13_349 MNMRMMLTLFVLVVMTTVSA SEH---EARGIS-WC-ESPDTCYGGCM--VYTDNTD--TCCQFVK--------------- V_1258_267 MNMRMMLTLFVLVVMTTVSA SEH---EARGIS-WC-ESPDTCYGGCM--VYTDNTD--TCCQFVKDQGRVPPARFCS--- ermineusAXL95565 MNMRMMLTLFVLVVVTTVSA SEH---EAKRQH-PCDESVEACYDWCKQ-LLDLRDD--KCCRFVDVSSVLSS-------- imperialisD0PX84 MIMRMTLTLFVLVVMTAASA SGDALTEAKRIP-YCGQTGAECYSWCIK--QDLSKD--WCCDFVKDIRMNPPADKCP--- marmoreusAFE82855 ---------------TAASA SGDALTEAKRIP-YCGQTGAECYSWCIK--QDLSKD--WCCDFVKDIRMNPPADKCP--- virgoAFE82856 ----------VLVVMTAASA SGDALTEAKRIP-YCGQTGAECYSWCIK--QDLSKD--WCCDFVKTIARLPPAHICS--Q magusMN517340 MIMRMTLTLFVLVVMTAASA SGDALTEAKRIP-YCGQTGAECYSWCIK--QDLSKD--WCCDFVKDIRMNPPADKCP--- [Superfamily L] [Framework XIV] [ /------Signal------/------------Pro------------/ /---C---C-----C----C----/P] A_0855_257 MKMSVTFIVVLMLTTSLTCGFSLFSNNGDRAVGPHDPDAADQLVREER ANLACNPPCTGNAMCQNGACGYIRFR V_CG13_006 MKMSVTFIVVLMLTTSLTCGFSLSSNNGERAYGPHDPDAADQLVREER ASLACNPPCTGNAMCQNGACSYIRFG V_1302_001 MKLWVTVIVVLMLTTSLTCGFSLSSNNGERAYGPHDPDAADQLVREER ASLACNPPCTGKAMCQNGACSYIRFG A_0885_017 MKMLVTFIVVLMLTTSLTCGFSLFSNNGDRAVGPHDPDAADQLVREER ANLACNPPCTGNAMCQNGACGYIRFR A_0885_018 MKLSVTFIVVLMLTTSLTCGFSLFSNNGERAFGPHDPDAADQLVREER ASSLCDPPCTGKAMCQAGKCGYARFG A_0055_217 MKLSVTFIVVLMLTTSLTCGFSLFSNNGERAFGPHDPDAADQLVREER ASSVCDPPCTGKAMCQAGKCGYARFG A_0039_192 MKMSVTFIVVLMLTTSLTCGFSLFSNNGDRAVGPHDPDAADQLVREER ANLACNPPCTGNAMCQNGACGYIRFR A_0039_193 MKLSVTFIVVLMLTTSLTCGFSLFSNNGDRAVGPHDPDAADQLVREER ANLACNPPCTGNAMCQNGACGYIRFR A_0039_194 MKLSVTFIVVLMLTTSLTCGFSLFSNNGERAFGPHDPDAADQLVREER ASSVCDPPCTGKAMCQAGKCGYARFG V_1278_088 ------FIVVLMLTTSLTCGFSHSSNNGERAYGPHDPDAADQLVREER ASLACNPPCTGKAMCQNGACSYIRFG A_0048_002 MKMSVTFIVVLMLTTSLTCGFSLFSNNGDRAVGPHDPDAADQLVREER ANLACNPPCTGNAMCQNGACGYIRFR A_0031_053 MKMSVTFIVVLMLTTSLTCGFSLFSDNGDRAVGPHDPDAADQLVREER ANLACNPPCTGNAMCQNGACGYIRFR A_1387_030 MKLSVTFIVVLMLTTSLTCGFSLFSNNGDRAVGPHDPDAADQLVREER ASLACNPPCTGNAMCQNGACGYIRFR A_1387_032 MKMPVTFIVVLMLTTSLTCGFSLFSNNGDRAVGPHDPDAADQLVREER ASLACNPPCTGNAMCQNGACGYIRFR A_0239_457 -----------------------------RAVGPRDPDAADQLVREER ANLACNPPCTGNAMCQNGACGYIRFR A_1387_031 MKLSVTFIVVLMLTTSLTCGFSLFSNNGERAFGPHDPDAADQLVREER ASSVCDPPCTGKAMCQAGKCGYIRFG ermineusAXL95523 MKMSVTFIVVLMLTTSLTCGFSLFSNNGDRAVGPHDPDAADQLVREER ANLACNPPCTGNAMCQNGACGYIRFR ermineusAXL95524 MKLSVTFIVVLMLTTSLTCGFSLLSNNGERA---NAASAADQLVHEER ASRACNPPCTGLSMCQGGKCGYKRFG eburneusADZ74127 MKLSVTFIVVLMLTTSLTCGFNLFSNNGKRAYGRHDPNAADRLVREKQ ASRACYPPCFGSSVCYGGRCFFIGFR flavidusAFU50771 MKLSVTFIVVLMLTTSLTFGFSLSSNNGERAYGSHHSYVADQLVRRER ASRACNPPCSDILTCLHGTCK----- litteratusADK47400 MKLVLAIILVLMLTTSLTCGFNHFSNNGKRAYGPHDRSAAHRLVSEKQ ARSLCHPPCTGLSMCHGGMCGYIRFR [Superfamily M-1] [Framework III] [ /-------Signal-----/----------------Pro-----------------//CC---C----C---CC----] V_1302_331 MMSKLGVLLTICLLLFPLTALPMDGDQ----PADLPALRTQ-D-------------- --------------------- V_1278_073 MMSKLGVVLTICLLLFPLTALPMDGDQ----PADLPALRTQ-DFEPERSPWFDPVKR CCSQNCRV--CIP-CCPY--- V_1258_126 MMSKLGVLLTICLLLFPLTAVPMDGDQ----PADLPALRTQ-DFAPERSPWFDPVKR CCSRDCRV--CTP-CCP---- V_1258_124 MMSKLGVVLTICLLLFPLTAVPMDGDQ----PADLPALRTQ-DFAPERSPWFDPVKR CCSRDCRV--CTP-CCP---- A_0031_360 MMSKLGVLLTICLLLFPLSAVPMDGDQ----PADLPALRTQ-DFEPERSPWFDPVKR CCSQDCRV--CIP-CCPNF-- A_0239_283 MMSKLGVLLTICLLLFPLSAVPMDGDQ----PADLPALRTQ-DFEPERNPWFDPVKR CCSQDCRV--CIP-CCP---- A_0025_286 MMSKLGVLMTICLLLFPLSAVPMDGDQ----PADLPALRTQ-DFEPERSPWFDPVKR CCSQDCRV--CIP-CCGY--- A_0025_288 MMSKLGVLLTICLLLFPLTAVPMDGDQ----PADLPALRTQ-DFEPERSPWFDPVKR CCSQDCRV--CIP-CCGY--- A_0025_289 MMSKLGVLLTICLLLFPLTAVPMDGDQ----PADQPALRTQ-DFEPERSPWFDPVKR CCSQDCRV--CIP-CCG---- V_1258_122 MMSKLGVLLTICLLLFPLTAVPMDGDQ----PADLPALRTQ-DFAPERSPWFDPVKR CCSQYCWK--CIP-CCPW--- V_1258_127 MMSKLGVLLTICLLLFPLTAVPMDGDQ----PADLPALRTQ-DFAPERSPWFDPVKR CCSRYCWV--CIP-CCPN--- V_1302_202 -MSKLGVVLTICLLLFPLTALPMDGDQ----PADLPALRTQ-DFEPERSPWFDPVKR CCSQYCWK--CIP-CCPW--- V_CG13_196 MMSKLGVLLTICLLLFPLTAVPMDGDQ----PADLPALRTQ-DFEPERSPWFDPVRR CCSQDCRV--CIP-CCR---- A_0039_162 MMSKLGVLLTICLLLFPLTAVPMDGDQ----PADLPALRTQ-DFEPERSPWFDPVRR CCSQDCSA--CIP-CCPW--- A_0885_076 MMSKLGVLLTTCLLLFPLSAVPMDGDQ----PADLPALRTQ-DFEPERSPWFDPVKR CCSQDCRA--CIP-CCP---- A_0055_127 MMSKLGVLLTTCLLLFPLSAVPMDGDQPADLPADLPALRTQ-DFEPERNPWFDPVKR CCSQDCSV--CIP-CCPW--- A_0055_129 MMSKLGVLLTTCLLLFPLSAVPMDGDQPADLPADLPALRTQ-DFEPERNPWFDPVKR CCSKDCWK--CTP-CCRDF-- K_0010_375 MMSKLGVLLTICLLLFPLTAVPLDGDQ----PADLPALRTQ-DFAPERSPWFDPVKR CCSRYCWV--CTP-CCPN--- A_0039_161 MMSKLGVLLTICLLLFPLSAVPMDGDQ----PADLPALRTQ-DIASDNSPWFDPVKR CCSRYCWV--CTP-CCPW--- A_0875_136 MMSKLGVLLTICLLLFPLSAVPMDGDQ----PADLPALRTQ-DFEPERSPWFDPVKR CCSQDCWK--CTP-CCPW--- V_1278_075 MMSKLGALLTICLLLFPLTALPLDGDE----PADRPAERMQDDNSAAEDPWFDPVKR CCKVCIYG--CSG-SCCD--- A_0520_183 --------------------------------------RTQ-DFEPERSPWFDPVKR CCSQDCRK--CIP-CCG---- A_0055_361 -------------------------------PADLPALRTQ-DFEPERNPWFDPVKR CCSTKCWQ--CTP-CCP---- A_0520_272 MMSKLGALLTICLLLFPLSAVPMDGDQ----PADLPALRTQ-DFEPERSPWFDPVKR CCSTKCWQ--CTP-CCP---- A_0520_273 MMSKLGALLTICLLLFPLTALSLDGDQ----PADLPALRTQ-DFEPERSPWFDPVKR CCSTKCWQ--CTP-CCP---- A_0048_074 MMSKLGVVLTICLLLFPLTALPMDGDQ----PADLPALRTQ-DIATDNSPWFDPVKR CCSRYCWV--CTP-CCPN--- A_0048_075 MMSKLGVVLTICLLLFPLTALPMDGDQ----PADLPALRTQ-DIATDNSPWFDPVKR CCSTKCWQ--CTP-CCP---- A_0031_359 MMSKLGVLLTICLLLFPLSAVPMDGDQ----PADLPALRTQ-DIASDNSPWFDPVKR CCSRYCWV--CTP-CCPW--- A_1387_132 MMSKLGVLLTICLLLFPLSAVPLDGDQ----PADQPALRTQ-DFEPEQSPWFDPVKR CCSTDCRT--CTP-CCRNV-- A_0885_075 MMSKLGALLTICLLLFPLTALPLDGDQ--------PAERMQ-DNSAAEDPWFDPVKR CCTV-CIHG-CSGKCCG---- A_0875_078 MMSKLGALLTICLLLFPLTALPLDGDQ--------PAERMQ-DNSAAEDPWFDPVKR CCDV-CIYG-CSGKCCG---- A_0875_079 MMSKLGVLLTICLLLFPLTALPLDGDQ--------PAERMQ-DNSAAEDPWFDPVK- --------------------- A_1387_133 MMSKLGALLTICLLLFPLTALPLDGDQ--------PAERMQ-DNSAAEDPWFDPVKR CCEV-CIHG-CSGNCCD---- A_0520_270 MMSKLGALLTICLLLFPLTALSLDGDQ--------PAERMQ-DNSAAEDPWFDPVKR CCEV-CIYG-CSGNCCG---- andremeneziATF27432.1 ---------TICLLLFPLTALSLDGDQ----PADHPAERMQ-DISPERSPWFDRAKR CCRVICSRYICLP-CCHH--- ermineusAXL95705 --------------------------Q----PADRPALRTQ-GIATDHSPWFNPVKR CCSQDCRI--CIP-CCPW--- betulinusAEX60382 MMSKLGVLLTVCLLLFPLTAVPMDGDQ----PADLPALRMQ-DFAPEHSPWFDPVRR CCSQDCRV--CIP-CCPH--- eburneusADZ99302 MMSKLGVLLTICLLLFPLTAVQLDGDQ----PADLPALRAQ-DFAPERSPWFDPVKR CCSQDCWV--CIP-CCPN--- lividusAEX60359 MMSKLGVLLTICLLLFPLTAVQLDGDQ----PVDLPALRTQ-DFAPEHSPWFDPVKR CCSRDCWV--CIP-CCPNGSA emaciatusAEX60371 MMYKFGVLLTICLLLFPLTAVQLDGDQ----PVDLPALRTQ-DFAPEHSPWFNPVKR CCSRHCWV--CIP-CCPNGS- praecellensATF27653.1 MMSKLGVLLTICLLLFPLTALPLDGDQ----PADQPVERML-DISPELNPWFDPVKR CCTQSLCHV-CSP-CCS---- [Superfamily M-2] [Framework III] [Mu/ Psi] [ /--------Signal----/-----------------Pro-----------------//CC------C---------C----CC-/P] V_CG13_320 MMSILGVLMTICLLLYPLTALPLDGDQ----PADRPAERMQ-DIASEQHPLFDHVK-R CCSW---PC------NMGCI--PCCIYP V_1302_342 -----------------------DGDQ----PADRPAERMQDDNSAAENPLLDPVK-R CCPW---PC------NIGCV--PCC--- V_1278_197 -------------------------DQ----PADRPAERMQDDNSAAENPLLDPVK-R CCPW---PC------NKGGV--PCC--- A_0048_250 -------LLTICRLLCPLTALSLDGDQ----PAGRPAERMQDDNSAAENPLYDPVK-R SGPS---PC------NIGCV--PCCS-- A_0048_248 MMSKLGVLLTICLLLFPITALPLDEDQ----PADRPAERMQDDNSAAENPLYDPVK-R CCPL---PC------DTACV--PCCW-- A_0520_274 MMSKLGALLTICLLLFPLTALSLDGDQ----PADRPAERMQDDNSAAENPLYDPVK-R CCPL---PC------DTACV--PCCW-- A_0520_182 ----------ICLLLFPLTALSLDGDQPADQPADRPAERMQDDNSAAENPLYDPVK-R CCPW---PC------NIGCI--PCC--- A_0048_302 MMSKLGALLTICLLLFPLTALSLDGDQ----PADRPAERMQDDNSAAENPLYDPVK-R CCPW---PC------NIGCI--PCC--G A_0048_301 MMSKLGVLLTICMLLFPLTAVPIDGD--------RPAERMQDDNSAAENPLYDP-K-R CCPW---PC------NIGCI--PCC--G A_0855_142 -------------------ALPLDGDQ----PADRPAERMQDDISPEQHPMFDKER-D CCKS---GC------HLGCS--PCC--G V_1258_123 -----------------------------------PAERMQDDISSEQHPLFDKER-R CCRD---KC------NLGCT--PCC--G V_1278_074 -------------LLFPLTALPLDGDE----PADRPAERMQDDISSEQHPLFDKER-G CCRD---KC------NLGCT--PCC--G V_CG13_031 -------------LLFPLTALPLDGDQ----PADRPAERMQDDISSEQHPLFDKER-R CCRD---KC------NLGCT--PCC--G V_1258_120 ----------------------------------RPAERMQDV-SSEQHPLFDPVK-R CCDW---PC------IPGCV--PCCFP- V_1302_176 MMSKLGALLTMCLLLFPLTALPLDGDQ----PADRPAERMQDDISSEQHPLFDKER-G CCPW---PC------NIGCT--PCC--G V_1258_125 MMSKLGALLTMCLLLFPLTALPLDGDQ----PADLPAERMQDDISSEQHPLFDKER-G CCPW---PC------NIGCT--PCC--G A_0039_191 MMSKLGVLLTICMLLFPLTAVPIDGDQ----PADRPAERMQDDISSEQHPFFDKER-G CCTA---GC------HDTCS--PCC--G A_0055_128 MMSKLGALLTICLLLFPLTALSLDGDQ----PADRPAERMQDDNSAAENPLYDPVK-R CCPW---PC------NIGCI--PCC--G A_0855_085 MMSKLGALLTICLLLFPLTALPLDGDQ----PADRPAERMQDNISSEQHPLFDKER-G CCTA---GC------HDRCS--PCC--G A_0239_200 -------------------------DQ----PADRPAERMQDNIPSEQHPLFDKER-R CCKS---GC------HRGCN--PCC--E A_0031_364 MMSKLGVLLTICMLLFPLTAVPIDGDQ----PADRPAERMQDDISSEQHPFFDKER-G CCTA---GC------HDTCS--PCC--G K_0010_377 -------------LLFPLTALPLDGDQ----PADRPAERMQDNISSEQHPLFDKEK-R CCTA---GC------HNGCS--PCC--G A_0031_363 -------------------------------------------ISSEQHPLFDKER-R CCKS---GC------HNGCN--PCC--E A_0520_271 MMSKLGALLTICLLLFPITALPLDEDQ----PADRPAERMQ-DVSSEQHPLFDPVK-R CCDW---PC------SLGCV--PCCYGG A_0048_247 MMSKLGVLLTICLLLFPITALPLDEDQ----PADRPAERMQ-DVSSEQHPLFDPVK-R CCDW---PC------SLGCV--PCCYGG A_0048_246 MMSKLGVLLTICLLLFPITALPLDEDQ----PADRPAERMQDDISSEQHPMFDKER-E CCTA---GC------HNGCN--PCC--G A_0048_249 MMSKLGVLLTICLLLFPITALPLDEDQ----PADRPAERMQDDISSEQHPMFDKER-D CCTA---GC------HDGCS--PCC--G ermineusAXL95500 MMSKLGVLMTICLLLFPLTAVPLDGDE----SADRPAERMQ-DTATEQHPLFDPVK-R CCDL---PC------TMSCI--LCCF-- ermineusAXL95371 ----------------------------------RPAERMQ-GIATERHPFFDPGK-L CCPQ---SC------TT-CW--PCC--- tessulatusAAG60351 MMSKLGVLLTICLLLFPLTAVRLDGDQ----HTDRPADRMQ-DIATEQHPLFDPVK-R CCDW---PC------TIGCV--PCCLP- coronatusAEX60300 MMSKLGVLLTICLLLFPITADPLVEDQ----PADRPADRMQ-DIATEQHPLFDPVK-R CCDR---PC------GIGCV--PCCLP- capitaneusAEX60419 MMSKLGVLLTICLLLFPITADPLVEDQ----PADRPADRMQ-DIATEQHPLFDPVK-R CCDR---PC------SIGCV--PCCLP- ermineusAXL95579 MMSKLGVLLTICLLLFPITALLMDGDQ----PADRPAERMEDDISSEVHRLLERRPPS CCKR---PC-------IVCWGVPCCPRG purpurascensP01406 -MSKLGALLTICLLLFPITALLMDGDQ----PADRPAERMDYDISSEVHRLLERRHPP CCMY--GRCRR----YPGCSSASCCQRG purpurascensADN79123 MMSKLGALLTICLLLFPITALLMDGDQ----PADRPAERMDYDISSEVHRLLERRHPP CCMY--GRCRRY----PGCSSASCCQGG ventricosusQ9BPJ2 MMSKLGALLTICLLLFPLTALPLDGDQ----PADRPAERMQDDISSEQHPLFDKE-RQ CCTG---SC-------LNCW--PCC--G radiatusADN79124 MMSKLGVLLTICLLLFPLTALPMDGDQ----PVDRLAERMQDNISSEQHTFFEKRLPS CCSLNLRLCP-----VPACKRNPCCT-G striatusAEX60437 MMSKLGVLLTICLLLFPLTALPMDEDQ----SVDRPAERMQDDISSEQHPLFNQK-RR CCRW---PCPRYVDDE-YCD---CCL-G consorsCCI55490 -MSKLGVLLTICLLLFPLTALPMDGDQ----SVDRPAERMQDDISSEQHPLFNQK-RR CCRW---PCPRKIDGE-YCG---CCL-G ermineusAXL95490 MMSKLGALLTICLLLFPITALLMDGDQ----PADRPAERMEDDISSEVHRLLERRPPG CCSW---PCPRYSNGKLVCF---CCL-G ermineusAXL95460 MMSKLGALLTICLLLFPITALLMDGDQ----PADRPAERTEDDISSDY--------IP CCSW---PCPRYSNGKLVCF---CCL-G magusQFQ61030 -----GVLLTICLLLFPLTAVPLDGDQ----PADRPAERMQDDISSEQHPLFNQKR-R CCRW---PCPRYVDDE-YCG---CCL-G [Superfamily M-2 WF] [No Framework] [ /-------Signal------/------------Pro-------/ /---------------------C--C] A_0855_107 -MSKLGVVLFTFLLLFPLATLQPIPDQ----PADRNAEPRGKIR DGMIGFLTGMLMGHSAKK---ACPWCG V_CG13_101 -MSKLGVVLFTFLLLFPLATLQPIPDQ----PADRNAEPRGKIR DGMNGILTGMLMGHSAK----SCPWCG V_1302_014 -MSKLGVVLFTFLLLFPLATLQPIPDQ----PADRNAEPRGKIR DGMNGILTGMLMWLSAK----SCPWCG V_1302_015 -MSKLGVVLFTFLLLFPLATLQPIPD--------RNAEPRGKIR DGMNGILTGMLMWLSAK----SCPWCG V_1278_010 -MSKLGVVLFTFLLLFPLATLQPIPDQ----PADRNAEPRGKIR DGMNGILTGMLMGHSAK----SCPWCG V_1258_059 -MSKLGVVLFTFLLLFPLATLQPIPDQ----PADRNAEPRGKIR DGMNGILTGMLMWLSAK----SCPWCG A_0885_014 -MSKLGVVLFTFLLLFPLATLQPIPDQ----PADRNAEPRGKIR DGMIGFLTGMLMGHSAKK---ACPWCG A_0875_050 -MSKLGVVLFTFLLLFPLATLQPIPDQ----PADRNAEPRGKIR DGMIGFSTGMLMGSSAQN---PCPWCG A_0055_066 -MSKLGVVLFTFLLLFPLATLQPIPDQ----PADRNAEPRGKIR DGMIGFLTGMLMGYSAQN---PCPWCG A_0039_164 -MSKLGVVLFTFLLLFPLATLQPIPDQ----PADRNAEPRGKIR DGIIGFLTGMLMGYSAKN---PCPWCG A_0239_065 -MSKLGVVLFTFLLLFPLATLQPIPDQ----PADRNAEPRGKIR DGMTGILTGMLMGYSAQN---PCPWCG A_0031_198 -MSKLGVVLFTFLLLFPLATLQPIPDQ----PADRNAEPRGKIR DGMTGILTGMLMGYSAQN---PCPWCG A_0520_256 -MSKLGVVLFTFLLLFPLATLQPIPDQ----PADRNAEPRGKIR DGMIGFLTGMLMGHSAKK---ACLWCG A_0025_036 -MSKLGVVLFTFLLLFPLATLQPIPDQ----PADRNAEPRGKIR DGMIGFLTGMLMGHSAKK---ACLWCG A_0048_236 -MSKLGVVLFTCLLLFPLATLQPIPDQ----PADRNAEPRGKIR DGMIGFLTGMLMGHSAKK---ACPWCG A_1387_043 -MSKLGVVLFTFLLLFPLATLQPIPDQ----PADRNAEPRGKIR DGMIGFSTGMLMGHSAKK---PCPWCG V_1258_060 --------------------------Q----PADRNAEPRGKIR DGMYGFLTRIFSGHPHHHYSFACLWCG K_0010_038 -MSTLGVVLFTFLLLFPLAALQPIQDQ----PADRNAEPRGKIR DGMNGFLTRIFCGHPHHHYSFPCPWCG ermineusAXL95438 -MSKLAVVLFTFLLLFPLATLQPIQDQ----PVDRNAELRGKIR DGMNGFLTAVLMGHPGHHHASPCPWCG [Superfamily M-3a] [Framework III] [ /-------Signal------/-----------Pro----------------------/ /CC----C-----C---CC----] A_0855_067 -MLKMGVVLFTFLVLFPLATLQLDAEQP---VERYAETEKNINPDERREFMLPIVR-- GCC--RACR-MPPCK--CCA---- A_0885_059 -MLKMGVVLFTFLVLFPLATLQLDADQP---VERYAETEKNINPDERREFMLPIVR-- GCC--RACR-MPPCK--CCA---- A_0039_126 -MLKMGVVLFIFLVLFPLATLQLDADQP---VERYAETEKNINPDERREFMLPIVS-- VCC--TACR-IPPCK--CCA---- V_1302_324 -----------------------------------AENKQDLNPDDRRDFMVPIVR-- GCC--TACR-MPPCT--CCA---- V_CG13_145 -MLKMGVVLFIFLVLFPLATLQLDADQP---VERYAENTKNINPDERRTFMLPIVR-- GCC--RACN-IPPCT--CCA---- V_1302_102 VMLKMGVVLFIFLVLFPLATLQVDADQP---VERYAENTKNINPDERRTFMLPIVR-- GCC--RACN-IPPCT--CCA---- V_1258_111 MMLKMGVVLFTFLVLFPLATLQVDADQP---VERYAENTKNINPDERRTFMLPIVR-- GCC--RACN-IPPCT--CCA---- V_1258_115 MMLKMGVMLFTFLVLFSLATLQLDADQP---VERYAENTKNINPDERRTFMLPIVR-- GCC--RACN-IPPCT--CCA---- V_1258_114 -MLKMGVVLFTFLVLFPLATLQLDADQP---VERYVENKQDLNPDERRDFMVPIVR-- GCC--TACR-MPPCT--CCS---- V_CG13_192 MMLKMGVMLFTFLVLFPLATLQLDADQP---VERRAENKQDLNPDDRRDFMVPIVR-- GCC--TACR-MPPCT--CCA---- V_1278_042 MMLKMGVVLFTFLVLFPLATLQLDADQP---VERYAENKQDLNPDERMNIMLPIQWQQ RCCISPLCD---DCI--CCITR-- A_0885_057 MMLKMGVVLFTFLVLFPLATLQLDADQP---VERYAENKQDLNPDERMDFILHSLRHV QCCPFPNCQ--KDCL--CCITL-- V_1278_041 MMLKMGVMLFIFLVLFPLATLQLDADQP---VERRAENKQDLNPDDRRDFMVPIVRHW NCCPMSACKPGSGCK-MCC----- V_CG13_144 MMLKMGVMLFIFLVLFPLATLQLDADQP---VERRAENKQDLNPDDRRD--------- ------------------------ A_0055_151 MMLKMGVVLFTFLVLFPLATLQMDADQP---VERYAENKHDLNPDERMDFILHSLRQR RCCLWPNCP--KGCF--CCLPP-- V_1258_105 ---------------------------------------QDLNPDERMEFILHALGQR RCCISPACH--DDCI--CCIIM-- V_1302_098 MMLKMGVMLFTFLVLFSLATLQLDADQP---VERYAENTKNINPDERREFMLPIVRQR GCCSMSACKLGSGCT--CCA---- V_1258_110 MMLKMGVVLFTFLVLFPLATLQVDADQP---VERYAENTKNINPDERREFMLPIVRQR GCCSMSACKLGSGCT--CCA---- A_0055_149 -MLKMGVVLFIFLVLFPLATLQLDADQP---VERYAENKQLLSPDERRDIILHVLRQE GCCDSQWCD--AGCD--CCKD--- A_0039_124 -MLKMGVVLFIFLVLFPLATLQLDADQP---VERYAENKQLLSPDERRDIILHVLRQE GCCDSQWCD--AGCD--CCKD--- V_1302_099 ---------------FPLATLQLDADQPVERVERYAENKQDLNPDERMKKIFPILWQR RCCILPLC---DDCL--CCIAR-- V_1258_108 ---------------FPLATLQLDADQP---VERYAENKQDLNPDERMKKIFPILWQR RCCILPLC---DDCL--CCIAR-- V_1302_100 ---------------FPLATLQLDADQT---VERYAENKQLLSPDERRDIILHVLRQR RCCISPLC---DDCI--CC----- V_CG13_143 -MLKMGVVLFIFLVLFPLATLQLDADQP---VERYAENKRLMSPAERRA-ILHAPRQQ VCCEPDWCD--GGCY-TCC----- V_1278_040 -MLKMGVVLFIFLVLFPLATLQLDADQP---VERYAENKRLMSPAERRA-ILHAPRQQ VCCEPDWCD--GGCY-ACC----- V_1258_107 ---KMGVVLFIFLVLFPLATLQLDADQP---VERYAENKRLMSPAERRA-ILHAPRQQ VCCEPDWCD--GGCY-ACC----- A_1387_080 -MLKMGVVLFIFLVLFPLATLQLDADQP---VERYAENKRLMSPDERR-AILHAPRQQ ECCAPEWCD--GGCY-GCC----- A_1387_077 MMLKMGVMLFTFLVLFPLATLQLDADQP---VERYAENKQDLNPDERMEFILHALGQR R----------------------- A_0885_060 MMLKMGVVLFTFLVLFPLATLQLDADQP---VERYAENKQDLNPDERMEFILHALGQR RCCVSPAC-Y-DGCI--CCVSIRL A_0520_112 ----MGVVLFIFLVLFPLATLQLDADQP---IERYAENKQDLNPDERMEFILHALGQR RCCVSPAC-Y-DGCI--CCISIRL A_0048_192 ----MGVVLFIFLVLFPLATLQLDADQP---IERYAENKQDLNPDERMEFILHALGQR RCCVSPAC-Y-DGCI--CCISIRL A_0520_116 MMLKMGVVLFTFLVLFPLATLQLDADQP---VERYAENKQDLNPDERMEFILHALGQR RCCVSPAC-Y-DGCI--CCISIRL A_0031_201 MMLKMGAMLFTFLVLFPLATLQLDADQP---VERYAENKQDLNPDERMDFILHALGQR RCCM-IVC-R-DYCY--CCIGR-L A_0520_111 MMLKMGVVLFTFLVLFPLATLQLDADQP---VERYAENKQDLNPDERMEFILHALGQW RCCVLPLC-H-DDCY--CCITG-- A_0520_117 ----MGVVLFIFLVLFPLATLQLDADQP---IERYAENKQDLNPDERMEFILHALGQW RCCVLPLC-H-DDCY--CCITG-- K_0010_289 --LKMGVVLFIFLVLFPLATLQLDEDQP---IERYAENKQDLNPDERMEFILHALGQR RCCVLPLC-H-DDCY--CCIIS-- A_0239_130 -MLKMGVVLFIFLVLFPLATLQLDADQP---VERYAENKRLMSPDERR-AILHAPREE DCCFPEWC-D-SGCEVGCCGD--- A_0031_020 ------------------------ADQP---VERYAENKRLMSPDERR-AILHAPREE DCCVPEWC-D-SGCEVGCCGD--- A_0031_202 ------------------------------------------------DIILHVLRQE GCCDSQWC-D-AGCD--CCKD--- A_0520_110 ----MGVVLFIFLVLFPLATLQLDADQP---IERYAENKQLLSPDERRDIILHVLRQE GCCDSSWC-D-AGCD--CCKD--- K_0010_383 ----MGVVLFIFLVLFPLATLQLDADQP---IERYAENKQDLNPDERMEFILHALGQR RCCVSPAC-Y-DGCI--CCVSIRL K_0010_334 ----MGVVLFIFLVLFPLATLQLYADQP---IERYAENKQDLNPDERLEFILHALGQR ------------------------ A_0520_114 -MLKMGVVLFIFLVLFPLATLQLDADQP---VERYAENKQLLSPDERRDIILHVLRQE GCCDSSWC-D-AGCD--CCKD--- A_0048_191 -MLKMG-VLFIFLVLFPLATLQLDADQP---IERYAENKQLLSPDERRDIILHVLRQE GCCDSLWC-D-AGCD--CCKD--- A_0025_423 --------------------LQLDADQP---VERYAENKQLLSPDERRDIILHVLRQK GCCDSEWC-D-PGCD--CCKD--- K_0010_291 -----------FLVLFPLATLQLDEDQP---IERYAENKQDLNPDERMEFILHALGQL RCCVSPSC-Y-YGCI--CCVSIRL leopardusQ5I2P0 -MLKMGVLLFIFLVLFPLTTLELDTDRP---VERHAAIKQDLKPQERRGIRLHAPRD- ECCEPQWC-D-GACD--CCS---- litteratusQ2I2Q5 -MLKMGVLLFTFLVLFPLTTLELDTDRP---VERHAAIKQDLKPQERRGIRLHAPRD- ECCEPQWC-D-GACD--CCS---- striatusAEX60092 -MLKLGMVLFIFLVLLPLATLHLDADQP---VERNANKQGLKPDERRR-FRFSAPRKR ECCELEWC-D-GACD--CCD---- variusAEX60091 -MLKLGMVLFIFLVLLPLATLHLDADQP---VERNVNKQGLKPDERRR-FRFSAPRKR ECCELEWC-D-GACD--CCD---- betulinusAEX60090 -MLKLGMVLFIFLVLLPLATLRLDADQP---VERNVNKQGLKPDERRR-FRFSAPRKR ECCELEWC-D-GACD--CCD---- vexillumAEX60145 -MLKMGVVLFVFLVLFPMATLQLDADQP---VERYAENKQDLNADERMGLILPALRQR TCCVRPWC-D-GACD--CCVDP-- ventricosusQ9BPH7 -MLKMGVVLFIFLVLFTLATLQLDADQP---VERYAENKRLMSPYKRRAILHAPREQ- ECCEPQWC-D-GGCD-ACC----- milesAEX60148 -MLKMGVVLFVFLVLFPLATLQLDADQP---VERYVENKQDLNADERMGLILPALRQQ SCCDIQWCYD--NCD--CCI---- coronatusAEX60031 MMLKMGVVLFVFLVLFPLATLQLDADQP---VERYVENKQDLNPDERRGFILPALKQK RCCPASAC-N-GACG--CCE---- K_0010_363 -------------------------------VERYVENKQDLNPDERRDFMVPIV--R GCCT--ACRM-PPCT--CCW---- ermineusAXL95462 -MLKMGVLLFIFLVLFPLATLQLDADQP---VERYAENKQNLNPDERRDFMLPIV-GR -CCT--ACNM-PPCQ--CCA---- ermineusAXL95530 -MLKMGVLLFIFLVLFPLATLQLDADQP---VERYVENKQDLNPDERRDLMLLAL-GR -CCT--ACRI-PECK--CCA---- arenatusAAG60380 -MLKMEVVLFTFLVLFPLSTLQLETDQP---VERYVENKQDLNPDESRNFMLPIV--K KCCT--ACRM-PPCK--CCA---- betulinusAEX60178 -MLKMGVVLFTFLVLFPLATLQLDADQP---VERYAENKQDLYPGESRGILKSAL--R KCCTMSVCQPPPVCT--CCA---- gloriamarisGFNK01000030 -MLKMGVVLFIFLVLFPLATLQLDADQP---VERYAENKQLLNPDERREIILHALGTR -CCSWDVC-DHPSCT--CCGG--- planorbisAEX60134 -MLKMGVMLFIFLVLFPLATLQLDADQP---VERYAENKQLLSPDERREIILHALGTR -CCSWDVC-DHPSCT--CCG---- textileAEX60127 MMLKMGVVLFIFLVLFPLATLQLDADQP---VERYAENKQLLSPDERREIILHALGTR -CCSWDVC-DHPSCT--CCG---- magusQFQ61038 --LKMGVVLFIFLVLFPLATLQLDADQP---VERYAENKQLLSPDERREIILHALGTR -CCSWDVC-DHPSCT--CCSG--- capitaneusAEX60112 MMLKMGVVLFVFLVLFPLATLQLDADQP---VERYAENKQDLNPDGKREFILPAVGRT -CCDLTWC-D-GNCR--CCTPR-- tessulatusAEX60060 -MLKMGVLLFTFLVLFPLATLQLDADQP---VERYAENKQDLNPDERMKFILHALGQR RCCISPACND--TCY--CCQDR-- rattusAEX60099 MMLKMGVVLFIFLVLFPLATLQLDADQP---VERYAENKQLLNPDEKRGILLPALRKF -CCDSNWCNI-SDCE--CCYG--- ebraeusAEX60109 MMLKMGVVLFVFLVLFPLATLQLDADQP---VERDAENKQDLHPDERTGFMLSAVGRR -CCSLRRCEP--HCH--CCVQRH- [Superfamily M-3a-WF] [No Framework] V_1302_325 ---------------------QLDADQPIERYAENKQDLNPDERREIILPALR-----LGRNQP-CEFPNAWC----- V_1258_109 MMLKMGVMLFTFLVLFPLATLQLDADQPIERYAENKQDLNPDERREIILPALR-----LGRNQP-CEFPNAWC----- A_0875_013 MMLKMGVVLFTFLVLFPLATLQLDADQPVERYAENKQDLNPDERREIILPAPR-----QRATQPPCMPMNPWC----- A_0855_069 MMLKMGVVLFTFLVLFPLATLQLDADQPVERYAENKQDLNPDERREIILPALR-----QRATQRPCLPMNPWC----- A_0055_152 MMLKMGVMLFTFLVLFPLATLQLDADQPVERYAENKQDLNPDERREIILPALR-----QRATQPPCHWPNVHC----- A_0039_125 MMLKMGVMLFTFLVLFPLATLQLDADQPVERYAENKQDLNPDERREIILPALR-----QRATQPPCHWPNVHC----- K_0010_335 -MLKMGVVLFTFLVLFPLATLQLDADQTVERYAENKQDLNPDERLEFILHALG-----QR------------------ A_0885_058 MMLKMGVVLFTFLVLFPLATLQLDADQPVERYAENKQDLNPDERREIILPALR-----QQAIQHPCSWMNPWC----- A_0239_128 ----------LFLVLFPLATLQLDADQPVERYAENKQDLNPDERREIILPALR------------------------- A_1387_079 MMLKMGVMLFTFLVLFPLATLQLDADQPVERYAENKQDLNPDERRE-------------------------------- A_0239_131 MMLKMGVMLFTFLVLFPLATLQLDADQPVERYAENKQDLNPDERREIILPALR-----Q------------------- A_0025_133 -----GVVLFTFLLLFPLVTLHMEVDQPVERNVEDEQALNPQERTEAIMTLLR------------------------- ermineusAXL95709 -----------------------DADQPVERHAENKQDLNPDERREIILPGLR-----HGRPSRS-YGWRT--G---- magusQFQ61047 -MLKMGAVLFTFLVLFPLATLQLDADQPVERHAENKQDLNPYERREIILPALR---------RRSGCPWVSWCG---- A_0025_254 -MLKMGVLLFIFLVLFPLATLQLDADQPVERYAENKQDFKPDERREIILPALGPPSVDKRATSLACAIWTK-C----- A_0025_251 -MLKMGVVLFTFLVLFPLATLQLDADQPVERYAENKQDFKPDERREIILPALGPPSVDKRATSLACAIWTK-C----- ermineusAXL95407 -MLKMGVLLFIFLVLFPLATLQLDADQPVERYAENKQDFKPDERREIILPALGPPSVDKRATSLACAIWTK-C----- planorbisAEX60027 -MLKMGVVLFIFLVLFPLATLQLNADQPVERHAENKQDLNPDKRREIIIPVQR-----RRRPYRRYGTCYCPIG---- [Superfamily M-3b] [Framework III] [ /-------Signal------/-----Pro--------------------------/ /CC---C------C-CC--------------] A_0875_138 ---------------------------------------------MHITSQGFSRR GCCVGQGCWNVPTCICCLKRQT---------- A_0885_061 ------------LVLFPLAMLQLVADQPVERQQDLNPGE-TRGMMMHITSQGFSRR GCCVGQGCWNVPTCICCVKRPT---------- A_0855_068 -MSKLGVVLFTFLVLFPLAMLQLVADQPVERQQDLNPGE-TRGMMMHITSQGFSRR GCCVGQGCWNVPTCICCVKRPT---------- V_CG13_079 -MSKLGVVLFTFLVLFPLAMLQLVADQPVERQQDLNPGE-TRGMMMHVMSKGFSRR GCCTGQGCWNVPTCECCV-------------- V_1302_103 -MSKLGVVLFTFLVLFPLAMLQLVADQPVERQQDLNPGE-TRGMMMHVMSKGFSRR GCCTGQGCWNVPTCECCV-------------- A_0055_150 ------------LVLFPLAMLQLVADQPVERQQDLNPGE-TRGMMMHVMSQGLSRR GCCVGQGCWNVPICECCDTGST---------- A_0039_127 ------------LVLFPLAMLQLVADQPVERQQDLNPGE-TRGMMMHVMSQGLSRR GCCVGQGCWNVPICECCDTGST---------- A_0025_252 -MSKLGVVLFTFLVLFPLAMLQLVADQPVERQQDLNPGE-TRGMMMHITSQGFSRR GCCVGQGCWNVPTCTCCVKRST---------- A_0520_115 -MSKLGVVLFIFLVLFPLAMLQLVADQPVERQQDLNPGE-TRGMMMHITSQGFSRR GCCVGQGCWNVPTCICCVKRPT---------- A_0239_129 -MSKLGVVLFTFLVLFPLAMLQLVADQPVERQQDLNPGE-TRGMMMHIMSQGLSRS SCCVGQGCWNVPICSCCKTSSI---------- A_0031_204 -MSKLGIVLFTFLVLFPLAMLQLVADQPVERQQDLNPGE-TRGMMMHIMSQGLSQQ DCCVGQGCWNVPICSCCKTSSI---------- A_0031_203 -MLKMGVVLFIFLVLFPLAMLQLVADQPVERQQDLNPGE-TRGMMMHIMSQGLSQQ DCCVGQGCWNVPICSCCKTSSI---------- ermineusAXL95344 -----GVVLFSVLVLFPLAMLQLVADQPVERQQDLNPGE-TRGMMMHITSQGFSRR GCCVGQGCWNVPTCTCCVKRST---------- V_CG13_361 -MSKLGVVLFTFLVLFPLATLQLEADQPVERQHDLNPGE-TRGIMMHVMSEGTSLR ACCVGQGCWNLPICKCCDVQSTWIIPTAISFP V_1278_186 -MLKMGVVLFIFLVLFPLATLQLEADQPVERQHDLNPGE-TRGIMMHVMS------ -------------------------------- V_1258_112 -MSKLGVVLFTFLVLFPLAMLQLVADQPVERQHDLNPGE-TRGMMMHVMSKGFSRR GCCTGQGCWNVPTCECCV-------------- V_1258_113 -MSKLGVVLFTFLVLFPLATLQLEADQPVERQHDLNPGE-TRGIMMHVMSEGTSLR ACCVGQACWNVPTCKCCDVQSTWIVPTAIRFP K_0010_382 -MSKLGVVLFTFLVLFPLATLQLEADQPVERQQDLNPGE-TRGIMMHVMSEGTSLR ACCVGQGCWNVPTCKCCDLQSTWIVPTVASVS ermienusAXL95479 -MSKLGVVLFTFLVLFPLTTLQLEADQPVERQQDFNPGE-TRGIMMHVLSKGTSLL GCCVGQGCWNVPICDCCNV------------- caracteristicusAEX60229 -MSKLGVVLFTILVLLPLATLLLEADQPVERQQDLNPQRGTRGIMKHVMSKGMSRR GCCTGQGCWNVPICECCD-------------- tessulatusAEX60231 ----MGLVLFIFLVLFPLATLHLKADQRVERQQDLNVGD-TRGIMRHAMSEGTSLR GCCTGSACWNNPTCGCCDD------------- [Superfamily M-3b-WF conomarphin] [No Signal, no Framework] V_CG13_136 -MSKLGVVLFIFLVLFPMATLQLDGDQTADRHADERDQDLTEQYRNLKRVLKRDWTHI--QAHPN-DNVVWSLV A_0055_199 -MSKLGVVLFIFLVLFPMATLQLDGDQTADRHADERDQDLTEQYRNLKRVLKRDLIHT--NAHPH-KNSVWSLV A_0875_132 -MSKLGVVLFIFLVLFPMATLQLDGDQTADRHADERDQDLTEQYRNLKHVLKRGWIHI--YAHPH-KNSWWTLV V_1302_069 -MSKLGVVLFIFLVLFPMATLQLDGDQTADRHADERDQDLTEQYRNLKRVLKRDWIRI--HAHPH-QNSWWSFV V_1278_071 -MSKLGVVLFIFLVLFPMATLQLDGDQTADRHADERDQDLTEQYRNLKRVLKRDWTRI--HPHPH--NSWWSLV V_1278_072 -MSKLGVVLFIFLVLFPMATLQLDGDQTADRHADERDQDLTEQYRNLKRVLKRGWRYG--YVHPHYSNAVWSLV V_1258_118 -MSKLGVVLFIFLVLFPMATLQLDGDQTADRHADERDQDLAEQYRNLKRVLKRGWRYG--YVHPHYSNAVWSLV A_0885_015 -MSKLGVVLFIFLVLFPMATLQLDGDQTADRHADERDQDLTEQYRNLKRILKRGW-HV--YEDPE-NNFWWSLV A_0520_238 -MSKLGVVLFIFLVLFPMATLQLDGDQTADRHADERDQDLTEQYRNLKRVLKRGWMHI--YAHPH-KNTWWTLV A_1387_044 -MSKLGVVLFIFLVLFPMATLQLDGDQTADRHADERDQDLTEQYRNLKRVLKR--MHI--YAHPH-KNSWWTLV A_0239_446 -MSKLGVVLFIFLVLFPMATLQLDGDQTADRHADERDQDLTEQYRNLKRVLKRGW--I--YAHPL-KNSWWTLV A_0239_445 -MSKLGVVLFIFLVLFPMATLQLDGDQTADRHADERDQDLTEQYRNLKRVLKRDLIHT--NAHPH-KNSVWSLV A_0031_009 -MSKLGVVLFIFLVLFPMATLQLDGDQTADRHADERDQDLTEQYRNLKRVLKRDLIHT--NAHPH-KNSVWSLV A_1387_045 -MSKLGVVLFIFLVLFPIATLQMDGDQLADRHAVERGQDPTQQNRNLRNVLKRSLRC---SGGPK-GNSFWTLV K_0010_468 -MSKLGVVLFIFLVLFPMATLQLDGDQTADRHADERDQDLAEQYRNLKRVLKRGWRYG--YVHPHFSNTFWSLV ermineusAXL95450 -MSKLGAVLFIFLVLFPMATLQLDGDQTADRHADERDQDRAEQYRNLRRALRGDSDDD--QVQPQ-DNSFYLLV betulinusAGE10519 -MSKLGVVLCIFLILFPMATLQLDGDQTADRHADERDQDLAGQYRNLKRVLKRGWVY---HANPE-ANSWWTLV andremeneziATF27409 -MSKLGVVLFIFLVLFPMTTVQLDGDQPANRHADERGQGLTDQYRNLRHVLKRGLRCA--GASYD-PNSWWTLV praecellensATF27631 -MSKLGVVLFIFLVLFPMTTVQLDGDQPANRHADERGQGLTDQYRNLRHVLKRGLRCA--GASYD-PNSWWTLV imperialisP0CH39 MMSKLGVLLCIFLVLFPMATLQLDGDQTADRHADQRGQDLTEQQRNSKRVLKKRDWEY--HAHPK-PNSFWTLV marmoreusAGE10522 MMSKLGVLLCIFLVLFPMATLQLDGDQTADRHADQRGQDLTEQQRNSKRVLKKRDWEY--HAHPK-PNSFWTLV gloriamarisGFNK01000032 -MSKLGVVLCIFLVLFPMATLQLDGDQTADRPADERGQDLAEQYRNLKRVMKRSSEHRAHHTHPN-DNSFWTLV magusQFQ61033 -MSKLGVMLFIFLVLFPMATLQLDGDQTADRHAGERDQDLVEQYRNLKHALKRTRNYY--VYSARPKNSWWS-- [Superfamily M-4] [Framework XXVII] [ /------Signal------/------------Pro--------------/ /-C------CC-------C-----C-----C----] A_0885_016 MSKLGVVLLIFLVLLPLTSPHQNDNRFAGNQVRQNDRQQRRSGLANALRR SSCGYLGQFCCTTPKRAYCHNWLTCNNVTKCVR--- A_0855_053 MSKLGVVLLIFLVLLPLTSPHQNDNRFAGNQVRQNDRQQRRSGLANALRR SSCGYLGQFCCTTPKRAYCHNWLTCNNVTKCVR--- A_0039_172 MSKLGVVLLIFLVLLPLTSPHQNDNRFAGNQARQNDRQQRRSGLANALRR SSCGYLGQFCCIAPKRAYCHNWLTCNNVTKCVR--- V_1302_209 MSKLGVVLLIFLVLLPLTSPHQNDNRFAGNQARQNDRQQRRNGLANALRR SSCGYLGQFCCIAPRRAYCHNWLTCNHVTMCVT--- V_1258_162 MSKLGVVLLIFLVLLPLTSPHQNDNRFAGNQARQNDRQQRRNGLANALRR SSCGYLGQFCCIAPRRAYCHNWLTCNHVTMCVT--- V_CG13_065 MSKLGVVLLIFLVLLPLTSPHQNDNRFAGNQARQNDRQQRRNGLANALRR SSCGYLGQFCCIAPRRAYCHNWLTCNHVTMCVT--- A_0055_080 MSKLGVVLLIFLVLLPLTSPHQNDNRFAGNQARQNDRQQRRNGLANALRR LSCGHLGQLCCIAPKRAYCHNWLTCNNVAKCVR--- A_0875_015 MSKLGVVLLIFLVLLPLTSPHQNDNRFAGNQARQNDRQQR-SGLANALRR SSCGNLGEFCCTVPRRAYCHNGLTCNDVTKCVR--- V_1278_103 MSKLGVVLLIFLVLLPLTSPHQNDNRFAGNQARQNDRQQRRNGLANALRR SNCGYLGQFCCTVPKRAYCHGRLKCNNRTKCIRQDA A_0025_062 MSKLGVVLLIFLVLLPLTSPHQNDNRFAGNQARQNDRQQRRNGLANALRR SSCGNLGEFCCIVPRRAYCHNWLTCNNVTKCVR--- A_0239_009 MSKLGVVLLIFLVLLPLTSPHQNDNRFAGNQARQNDRQQRRNGLANALRR LSCGHLGQLCCIAPKRAYCHNWLTCNNVAKCVR--- A_0031_032 MSKLGVVLLIFLVLLPLTSPHQNDNRFAGNQARQNDRQQRRNGLANALRR SSCGNLGEFCCTVPRRAYCHNGLTCNDVTMCVR--- A_1387_075 MSKLGVVLLIFLVLLPLTSPHQNDNRFAGNQARQNDRQQRRNGLANALRR SSCGNLGQFCCIAPKRAYCYNGLTCNDQTKCV---- A_0048_011 MSKLGVVLLIFLVLLPLASPHQNDNRFAGNQARQKDRQQRRSGLANALRR SSCGNLGEFCCIAPKRAYCQNGLTCNDVTKCVR--- betulinusAMP44674 MSKLGVVLLIFLVLLPLTSPHQNGNGFAGNRARQNDMQRRKNGLTNSLRR SSCGYVGQPCCIVPRRAYCHGDLNCNNVAMCVR--- marmoreusACV87166 MSKLGVVLLIFVVLLALTSPHHYGNRFAGYQARQMGVQQRKNALANALRR SGCGYLGEPCCVAPKRAYCHGDLECNNVAMCVN--- litteratusACV87169 MSKLGVVLLIFVVLLALTSPHHYGNRFAGYQARQMGVQQRKNALANALRR SGCGYLGEPCCVAPKRAYCHGDLECNNIAMCVN--- eburneusACV87167 MSKLGVVLLIFVVLLALTSPHHYGNRFAGYQARQMGVQQRKNALANAVRR SGCGYLGEPCCISPKRAYCHGDLECNNVAMCVN--- [Superfamily M-5] [Framework IX] [ /------Signal------/-----------------Pro---------------//C------C--C------C----------C--C--/-] V_CG13_165 -----------------------DD-PRRQRDEKQSPQRDIVRGTMRKYRYNIQRR C-VNSTPCGECTREGKTCVVKSGGKGT-CGECVSARR A_0875_080 MSKVGVVLLIFLVLLSLAALQNGGD-PRRQR-----------RSTLRKYSYNIQRR C-VYSTPCEECRKSGKICTVQPGGRGT-CGECNPRRR A_0039_075 MSKVGVVLLIFLVLLSLAALQNGGD-PRRQR-----------RSTLRKYSYNIQRR C-VYSTPCEECRKSEKICTVQPGGRGT-CGECNPRRR A_0239_339 MSKVGVVLLIFLVLLSLAALQNGDD-PRRQR-----------RSTLRKYSYNIQRR C-VYSTPCEECRKSEKICTVQPGGKGT-CGECNPRPR A_0239_340 -----------------------------------------------RYSYNIQRR C-VYSTPCEECRKSEKICTVQPGGKGT-CGECNPRPR A_0031_002 -----------------------------------------------RYSYNIQRR C-VHSTPCKECRKNEKICTVQPGGKGT-CGECKPRRR A_0031_003 MSKVGVVLLIFLVILSLAALQNGGD-PRRQR-----------RSTLRKYSYNIQRR C-VHSTPCKECRKNEKICTVQPGGKGT-CGECKPRRR K_0010_395 MSKVGVVLLIFLVLLSLAALQNGDD-PRRQRDEKQSPKRDIFRSTLRKYSYKTRRR C-AFSTPCGECIRTGKICSVQPGGKGT-CG------- betulinusAMP44675 MSKVEVVLLIFLGLLSLAALQNGDDSSRRQRDGKQSPQRDIVRRTRRRYNDNIQRR C-VNSTPCSECTNEGKICSVKPGGKGT-CGECVQARR imperialisAME17673 MSKVGVVPLIFLVLLSIAALQNGDD-PRRQRDEKQSPQGDILRSTLTKYSYNIQRR CWAGGSPCHLC-SSSQVCIAPTGHPAIMCGRCVPILT andremeneziATF27413 MSKVGVVLLIFLVLLSLAALQNGDD-PRQQRGEKQSPQRDNFRSTLRKYSHNIQRR CRNGTSSCTTCARKGKDCMGRRGGGKR-CGKCVPRGR magusDAC80582 MTKVEVVLLIFLVLLSLASLQNGDD-PRRQRDEKQSPQRRIVQGTLRKYMYNIQRR C-AYGTPCSDCTSAGKVCSVKSGGKGS-CGTCVPGAK [Superfamily M-5-WF] [No Signal, no Framework] V_1302_055 MSKVEVVLLIFLVLLSLAAVQNADD-PRRQRDEKQSPQRDIVQDTVITSNDVARTVPHGETETEGKKNSWWTLKERATAGSAFQHADKTSLTNP V_1258_008 MSKVEVVLLIFLVLLSLAALQNADD-PRRQRDEKQSPQRDIVQDTVITSNDVARTVPHGETETEGKKNSWWTV--------------------- A_0025_387 MSKVEVVLLIFLVLLSLAALQNADD-PRRQRDEKQSPQRDIVQDTVITSNDVARTAPHGESGTDKKPNSWWSLFKRATAGSAFQHTDKTSPTNP [Superfamily M-6] [Framework VIII] [ /-------Signal-----/---------------Pro--------------/ /------C----C-----C----C--C--C------C--C-C------C-/] A_0055_081 --SKLGVVLAIFLVLSSMEALHLDADGLAGVATKQKVDKNAVAEKSILALGLR GEDDIGLCESSICASDEECNPEKCGPCGLCTMQGPECWHCECAQTNPGCLHK A_0039_131 MMSKLGVVLAIFLVLSSMEALHLDADGLAGVATKQKVDKNAVAEKSILALGLR GEDDIGLCESSTCASDEECYPEICGPCGLCTMQGPKCWHCECAQTNPGCPHK A_0031_446 -----------------------------------------VAEKSILALGLR GEEDIGLCESSTCASDEECYPDKCGSCGLCTMQGPKCWHCECAQTNPGCPHK A_1387_224 --------------------LHLDADGLAGVATKQKVDKNAVAEKSILALGLR GEDDIGLCESSTCESNEDCHLEKCGTCALCTMQDPKCWHCECAQTNPGCPHK betulinusAMP44679 MMSKLGAVLVIFLVLSSMEALHLDADGLAGVTTKQKVDKKSVAENSILALALR GEEDIGLCESSTCASDEECHPDKCGRCGLCTSQSPKCWHCECAQTNPGCDHK [Superfamily M-7] [Framework XVI] [ /-------Signal-----/--------------Pro----------/ /-------C---C----CC-------------/---] V_CG13_002 MSNLGIVLFIFLGLFSLETLQLDADQPADRHAEKRGMDLNKLHQNMMR ALLKREVRCDGYCPDDICCKRNFLRGIKLTASEKRRE V_1302_086 MSNLGIVLFIFLGLFSLETLQLDADQPADRHAEKRGMDLNKLHQNMMR ALLKREVRCDGYCPDDICCKRNFLRGIKLTASEKRRE V_1258_119 MSNLGIVLFIFLGLFSLETLQLDADQPADRHAEKRGMDLNKLHQNMMR ALLKREVRCDGYCPDDICCKRNFLRGIKLTASEKRRE A_0055_005 MSNLGIVLFIFLGLFSLETLQLDADQPADRHAEKRGVDLNEPNQNMMR ALLKREVRCNGYCPDDICCKKNFLRGIKLTASEKRHE A_0039_160 MSNLGIVLFIFLGLFSLETLQLDADQPADRHAEKRGVDLNEPNQNMMR ALLKREVRCNGYCPDDICCKKNFLRGIKLTASEKRHE A_0239_258 MSNLGIVLFIFLGLFSLETLQLDADQPADRHAEKRGVDLNEPNQNMMR ALLKREVRCNGYCPDDICCKKNFLRGIKLTASEKRHE A_0025_029 MSNLGIVLFIFLGLFSLETLQLDADQPADRHAEKRGVDLNEPNQNMMR ALLKREVRCNGYCPDDICCKKNFLRGIKLTASEKRHE A_0031_261 MSNLGIVLFIFLGLFSLETLQLDADQPADRHAEKRGVDLNEPNQNMIR ALLKREVRCNGYCPDDICCKKNFLRGIKLTASEKRHE K_0010_459 MSSLAIVLFIVLVLFPLATLQLDAVQPADRHAEKRGQDQNEMYQNLKR VLLKRGVRCNGYCPDDVCCKRNFLRGIKLIAPEKR-- [Superfamily M-8] [Framework XXII] [ /--------Signal-----/---------------Pro---------------/ /--C----C-----C---C-C-------C--C-C--] A_0885_147 MMLKLRVVLYILVVLLPLTTLQEKEDDASEALVKRLDEKIAEGAIVMPDLTRNTR GNSCDSNGCNNDTNCSTNCSCILNMAQRCNNCHCESS A_0855_155 -MLKLRVVLYILVVLLPLTTLQEKEDDASEALVKRLDEKIAEGAIVMPDLTRNTR GNPCDSNGCNNVT------------------------ A_0039_070 -MLKLRVVLYILVVLLPLTTLQEKEDDASEALVKRLDEKIAEGAIVMPDLTRNTR GIPCDSNECNNDTDCS-NCSCMWNMALRCNYCYCESS A_0055_015 -MLKLRVVLYILVVLLPLTTLQEKEDDASEALVKRLDEKIAEGAIVMPDLTRNTR GIPCDSNECNNDTDCS-NCSCMWNMALRCNYCYCESS V_1302_213 MMLKLRVVLYILVVLLPLTTLQEKEDDASEALVKRLDEKTAEGAIVMPDLTRDTR DNPCDSNGCNNDTDCSTNCSCILNTFQRCDYCYCESS A_1387_021 -MLKLRVVLYILVVLLPLTTLQEKEDDASEALVKRLDEKIAEGAIVMPDLTRDTR GNPCDSNRCNNDADCS--------------------- A_0239_003 -------------------------------LVKRLDEKIAEGAIVMPDLTRNTR GNPCDSNGCNNDTDCS-NCSCIWNMRSRCSNCYCES- A_0031_004 -MLKLRVVLYILVVLFPLTTLQEKEDDASEALVKRLDEKIAEGAIVMPDLTRNTR GNPCDSNGCNNDTDCS-NCSCIWNMHSRCSNCYCES- betulinusAMP44670 MMLKLRVVVYILLVLLPLTTLQEKEDDASDALVKQVDEKIAKGAILMPDLSRDTR D-PCSSDGCNNDTDCSAGCSCTFNMALRCDYCYCGSS [Superfamily N-1] [Framework XV] [ /------Signal-------/---------------Pro----------------/ /C-----C-------CC----C-C------------C-C-/] A_0055_181 ----------LLLLLPLGTSDGDGQAIPRGGVPSAVSSRVRRLLGGDKKSGRSLEKR CISGKICGGGAVTVCCRRTDCTCHLLQSRPLYRLVCACPD A_0039_083 ----------LLLLLPLGTSDGNGQATPRGGVPSAVSSRVARLLGGDKKSGRSLEKR CASGKICGGGAMTVCCGHGDCTCHLLKTRPGFRLVCVCPD A_0855_112 -MSLKTMLLILLLLLPLGTSDGDGQAIPRGGVPSAVSSRVRRLLGGDKKGGRSFEKP CISGKICGGGEVTVCCKHTDCTCHLLQSRPWSRLVCACPV A_0025_238 -MSLKTMLLILLLLLPLGTSDGDGQATPRGGVPSAVSSRVARLLGGDKKSGRSLEKR CRSGRTCGGGENTVCCGHADCTCRLLQSRPWSRLVCVCDK marmoreusP0DM18 -MSLKMMLLILLLLLPLATFDSDGQAIPGGGIPSAVNSRVGRLLGGDEKSGRSLEKR CSSGKTCGSVEPVLCCARSDCYCRLIQTRSYWVPICVCP- marmoreusP0DM19 -MSLKMMLLILLLLLPMATFDSDGQAIPGGGIPSAVNSRV----GGDEKSGRSLEKR CRSGKTCPRVGPDVCCERSDCFCKLVPARPFWRYRCICL- betulinusAMP44681 MMSLKMMLLILLLLLPLATFDSDGQAIPGDGVPSPMSSRIRRLLGGDKKSGRSPRS- CPSNKYCGGG---LCCRSAECTCAIVWSRPWSKVVCVCG- [Superfamily N-2] [Framework XV] [ /------Signal-------/--------------------Pro--------------------//C-----C---CC----C-C-----------C-C------/] A_0055_147 -MS-LGMVLLLLLLLLPLGNSDGDGDRQAMDRDSAAGEARSAP-----GHLLGRHVDHGRSADKH CST-KTCGSTCCTSISCTCEVHGSVSNVKGCSCP------K A_0239_249 -MS-LGMVLLLLLLLLPLGNSDGDGDRQAMDRDSAAGEARSAP-----GHLLGRHVDHGRSADKH CST-KTCGSTCCTSISCTCEVHGSVSNVKGCSCP------K A_0520_045 -MS-LGMVLLLLLLLLPLGNSDGDGDRQAMDRDRTAGEARSAP-----RLRLRRHMHHGRSADKR CST-KVCGEECCSSSACECYAHGGSSNEQTCSCPG-----K A_0048_103 -MS-LGMVLLLLLLLLPLGNSDGDGDRQAMDRDRAAGEARSAP-----RLRLRRHMHHGRSADKR CST-KVCGEECCSSSACECYAHGGSSNEQTCSCPG-----K A_0875_023 ---------------------------------------------------------HGRSADKR CST-KKCGVTCCTSISCTCDVRGQESNEKGCNCPRRATLAK V_1302_047 -MS-LGMVLLLLLLLLPLGNSDGDGDRQAMDRDRAAGEARSAR-----GHLLRRHVDHGRSADKR CST-KKCGDDCCSSSSCECEYHGGTSNEIGCSCPIRAILAK V_1278_030 -MS-LGMVLLLLLLLLPLGNSDGDGDRQAMDRDRAAGEARSAP-----GLLLGRHVDHGRSADKR CST-KKCGDHCCSSSSCECERHGGTSNEKGCTCPGRAILAK V_1258_039 -MS-LGMVLLLLLLLLPLGNSDGDGDRQAMDRDRTAGEARSAP-----RLRLRRRKDHGRSPDKR CDT-ITCGGDCCPSSSCECEVHGGTSNEVGCSCPVLAILAK A_0048_104 -MS-LGMVLLLLLLLLPLGNSDGDGDRQAMDRDRAAGEARSAP-----RLRLRRRKDHGRSPDKR CDT-ITCGGDCCPSSSCECEVHGGSSNEVGCSCPVLAILAK A_0520_046 -MS-LGMVLLLLLLLLPLGNSDGDGDRQAMDRDRTAGEARSAP-----RLRLRRRKDHGRSPDKR CDT-ITCGGDCCPSSSCECEVHGGSSNEVGCSCPVLAILAK A_1387_183 -MS-LGMVLLLLLRLLPLGNSDGDGDRQAMDRDRAAGEARSAP-----RFLLGRHVDHGRSADKR CST-KKCGVFCCP-ISCTCVIRGQESNERGCLCPGRATLAK A_0039_031 -MS-LGMVLLLLLRLLPLGNSDGDGDRQAMDRDRAAGEARSAPGHLLGSLFTDRHVDHGRSADKR CSSNKMCDDNCCSSSSCTCVILGQHSNEKACSCPGRATHAK A_0048_102 -MS-LAMVLLLLLRLLPLGNSDGYGDRQAMDRDRAAGEARSAP-----RLRLRRHVDRGRSADKR CSSNKMCGDNCCSSSSCTCVILGQHSNEKGCSCPGRATHAK A_0031_325 ------------------------------------------------------HVDHGRSADKR CSSKKMCGDSCCPSSSCECSNAGQHSNEKGCLCPVRATLAK A_1387_182 -MS-LGMVLLLLLRLLPLGNSDGDGDRQAMDRDRAAGEARSAF-----RLRLRRHVDHGRSADKP CSSQKKCGNNCCPSSSCTCNVFGQHSNEEGCLCPSGP--PS K_0010_308 -MSTLGMVLLLLLLLLPLGNSDGDGDRQAMDRDRTAGEARSAP-----RLRLRRRKDHGRSPDKR CDT-ITCGGDCCPSSSCECEVHGGSSNEVGCSCPVLAILAK K_0010_216 -MSTLGMVLLLLLLLLPLGNSDGDGDRQAMDRDRTAGEASSAP-----RLRLRRRKEHGRSPDKR C---------------------------------------- betulinusALM87495 -MS-LGMVLLLLLLLLPLGNSDGDGDRQAMDRDRTAGEARSAP-----NLHLRRHMDHGRSAVKR CST-KVCGDDCCPSSECECAVHGGTGNEVGCSCPVRALYRK [Superfamily O1-1] [Omega/ Kappa] [Framework VI/VII] [ /----------Signal-----/------Pre--------/ /-----C------C------CC---C-------C] A_0885_093 --KLTCVLIVAVLFLTACQLITADDSRRTQKHRALRSTTKR ATSNRPCKPKGRKCFPHQKDCCNKTC--TRS-KCP A_0025_125 -MKLTCVVIVAVLFLTACQLITADDSRRTQKHRALRSTTKR ATSNRPCKPKGRKCFPHQKDCCNKTC--TRS-KCP ermineusAXL95468 -MKLTCVVIVAVLFLTACQLITADDSRRTQKHRALRSTTKR ATSNRPCKPKGRKCFPHQKDCCNKTC--TRS-KCP purpurascensAAQ05867 ------VVIVAVLFLTACQLITADDSRRTQKHRALRSTTKR ATSNRPCKKTGRKCFPHQKDCCGRAC--IIT-ICP A_0025_124 -MKLTCVVIVAVLFLTACQLITADDSRRTQKHRALRSTTKL SMLTRQCTPHGGSC-GLVSTCC-GRCNVPRN-KCE ermineusAXL95467 -MKLTCVVIVAVLFLTACQLITADDSRRTQKHRALRSTTKL SMLTRQCTPHGGSC-GLVSTCC-GRCNVPRN-KCE victoriaeJAB84671 -MKLTCVVIVAVLFLTACQLITADDSRSTQKHRALRSTIKH SMLTRSCTPPGGPC-GYYNNCCSHQCNINRN-KCE betulinusAMP44622 -MKLTCVVLVAVLFLTACQLITADGSRGTQKHRALRSTTKL FMLTEICTPPGGHC-GFYSSCC-GTCNVHRN-SCV litteratusQ2I2R2 -MKLTSVVIVAVLFLAACQLTTSDGSRGTWKDRAVRSITKV SMLRWPCKVAGSPC-GLVSECC-GTCNVLRN-RCV magusP05484 -MKLTCVVIVAVLLLTACQLITADDSRGTQKHRALRSTTKL STSTR-CKGKGAKCSRLMYDCCTGSC---RSGKCG [ziconotide] consorsCCI55499 -MKLTCVVIVAVLLLTACQLITADDSRGTQRHRALRSDTKL SMSTR-CKGKGASCSRTMYNCCSGSC---NRGKCG achatinusP0C8V8 -MKLTCVVIVAVLLLTACQLLTADDSRGTQKHRALRSDTKL SMSTR-CKGKGASCSRTMYNCCTGSC---NRGKCG striatusP0C831 -MKLTCVVIVAVLLLTACQLLTADDSRGTQKHRALRSDTKL SMSTR-CKGKGAPCRKTMYDCCSGSC--GRRGKCG catusAAF89881 ------VVIVAVLLLTACQLITANDSRSTQKHRALRSDTKL SMSTR-CKGKGASCRRTSYDCCTGSC---RSGRCG geographusBAO65614 -MKLTCVVIVAVLLLTACQLITADDSRGTQKHRALRSSTKL TLSTR-CVPSGGSCSRTAYSCCHGSC---SGGRCG A_0239_150 -MKLTCVLIVAALFLMACQLTTTVDAGGKQKDHDLRSIVKN SRLTKRCKTKGAYC-FDDNECCE-ACDWIRD-RCT striatusQ5K0D7 -MKLTCVVIVAVLLLTACQLITADDSRGTQEHRALRSDTKL SMLTLRCESYGKPC-GIYNDCCN-ACDPAKK-TCT bullatusP0CY67 ----------AVLLLTACQLITAEDSRDTQKHRALRSDTKL SMLTLRCATYGKPC-GIQNDCCN-ICDPARR-TCT [Superfamily O1-2] [Mu] [Framework VI/VII] [ /---------Signal---/----------------Pro---------------//-C------C--------CC-----C-----------C-------------] A_0885_092 -MKLTCALIVAVLFLTACQLTTTDDS-RDKQKYLAKRSRAKMQ--N---YKLTKR -CDPPGHECE--YWENHCCD---ACKIGSE--KPGVCS-E----------- A_0055_100 -MKLTCALIVAVLFLTACQLTTTDDS-RDKQKYLAKRSRAKMQ--N---YKLTKR -CDPPGHECE--YWENHCCD---ACKIGSG--KPGVCS-E----------- A_0039_139 -MKLTCALIVAVLFLTACQLTTTDDS-RDKQKYLAKRSRAKMQ--N---YKLTKR -CDPPGHECE--YWENHCCD---ACKIGSG--KPGVCS-E----------- V_1278_065 -MKLTCALIIAMLLLTACQLITTDDS-RDKQKYLAKRSRAKMQ--N---YKLTKR -CDPPDHECE--LWNNHCCD---ACKIRSG--QSNVCSDE----------- A_0520_223 -MKLTCALIVAVLFLTACQLTTTDDS-RDKQKYLAKRLRAKMQ--N---YKLTKR -CDPPGSECE--LWENYCCD---ACKIRSG--NPNVCSDE----------- A_0048_116 -MKLTCALIVAVLFLTACQLTTTDDS-RDKQKYLAKRSRAKMQ--N---YKLTKR -CDPPGRECE--LWENYCCD---ACKIRSG--KPNVCSDE----------- A_0239_395 -MKLTCALIVAVLFLTACQLTTTDDSTRDKQKYLAKRSRAKMQ--N---YKLTKR -CDSPGSECE--LVENYCCD---ACKIRSG--RPNVCSDE----------- V_1302_171 ------ALVIAMLLLTACQLITTDDS-KDKQKYLAKRSRAKMQ--N---YKLTKR -CDPPGHECE--LWKNDCCD---ACKIRHG--RPNVCSDE----------- A_0055_101 -MKLTCALIVAVLFLTACQLTTTDDS-RDKQKYLAKRSRAKMQ--N---YKLTKR -CDSPGSECE--LVENYCCD---ACKIRSG--RPNVCSDE----------- A_0239_396 -MKLTCALIVAVLFLTACQLTTTDDS-RDKQKYLAKRSRAKMQ--N---YKLTKR -CDSPGSECE--LVENYCCD---ACKIRSG--RPNVCSDE----------- A_1387_267 -MKLTYALIVAMLFLMACQHITTDDS-RGEQKYLAKRSKAKIQ--NFKLFKLTKR -CDSPGAACS----------------------------------------- A_0048_115 -MKLTCALIVAVLFLTACQLTTTADS-RGRQEYPTKRLRAKMP--NSKLFRLTKR -CEAPGAACS--KYDNECCD---ACLLQHP--LPPVCVV------------ A_0520_224 -MKLTCALIVAVLFLTACQLTTTADS-RGRQEYPTKRLRAKMP--NSKLFRLTKR -CEAPGAACS--KYDNECCD---ACLLQHP--LPPVCVV------------ K_0010_370 -MKLTCALIVAVLFLTSCQLTTTDHS-RGRQEYTTKRLRATMQ--NSKLFRLNKR -CEAPGAACS--KYDNECCD---ACLLQHP--LPPVCVV------------ betulinusAMP44713 -MKLTCTVIIAVLFLTACQLTTAVDS-RGRQGYRAARARIKMQ--NDKIFKLTKR -CDAPGAPCS--KYDNECCD---ACMLSHP--EPPVCVG------------ praecellensATF27671 -MKLTYALIVAMLFLTACQLITTDDS-RGRQEYRGARARTKMQ--NYKIFKLTKR -CDPPGAACS--RTNNQCCH---ACSSPPPGQGKGKCTNA----------- milesQ3YEG3 -MKLTCALIVAMLLLTACQLITTDDF-RGRQQYRTARSRTKMQ--NYKIFRLTKR -CDAPNAPCE--KFDNDCCD---ACMLREK--QQPICAV------------ lividusQ3YEE6 -MKLTCALIVAMLFLTACQLTTTDDS-RGRQKYPTERLRVKMR--NPKLSKLTKT -CDPPGDSCS--RWYNHCCS--KLCTSRNS---GPTCSRP----------- V_1302_110 -MKLTCVVIVAVLFLMACQLTTADDS-RGKQGYPALTLRTMMQ--NSRRSKLAKR -CDAKDSPCQ---FDSECCS-G-ACTPEGV---FDYCR------------- V_CG13_118 -MKLTCVVIVAVLFLMACQLTTADDS-RGKQGYPALTLRTMMQ--NSRRSKLAKR -CDAKDSPCQ---FDRECCS-G-ACTPEGV---FDYCR------------- A_0025_122 -MKLTCVVIVAVLFLTACQLTTADDS-RGKQGYPALTLRTMVQ--NSRRSKLAKR -CDAKDSPCQ---FDSECCS-G-ACTPEGV---FDFCR------------- A_0039_180 -MKLTCVVIVAVLFLMACQLTTADDS-RGKQGYPALTLRTMMQ--NSRRSKLAKR -CDAKDSPCQ---FDSECCS-G-ACTPEGV---FDFCR------------- A_0885_087 -MKLTCVVIVAVLFLMACQLTTADDS-RGKQGYPALTLRTMMQ--NSRRSKLAKR -CDAKDSPCQ---FDSECCS-G-ACTPEGV---FDFCQ------------- V_1278_066 -MKLTCVVIVAVLFLMACQLTTADDS-RGKQGYPALTLRTMMQ--NSRRSKLAKR -CDAKDSLCQ---FDSECCS-G-ACTPEGL---FDFCQ------------- A_0048_085 -MKLTCVVIVAVLFLMACQLTTADDS-RGKQGYPALTLRTMVQ--NSRRSKLAKR -CDAKDSPCQ---FDSECCS-G-ACTPEGL---FDFCQ------------- A_0520_248 ---LTCVVIVAVLFLTACQLTTADDS-RGKQVYPALTLRTMVQ--NSRRSKLAKR -CDAKDSPCQ---FDSECCS-G-ACTPEGV---FDFCQ------------- capitaneusQ5K0C4 -MKLTCVLIVVVLFLTACQLITTDDS-TGKQRYQAWKLRSKMQ--NSVLSRLSKR -CDEEGTGCS---SDSECCS-G-RCTPEGL---FEFCE------------- magusAAZ83773 -MKLTCVLIVVVLFLTACQLIPADYS-RDTPGYPAWKLKTKMQ--NSRRWKLAKR -CKGKGAGCD---YSHECCS-R-QCTGRI----FQTCN------------- V_CG13_095 -------------------------T-RDKQEDPVVRSSDEMQ--RSEDPKLAKR -CTDFGGDCD--LDNHDCCS-G-ECFGFPELA---VCT------------- V_1258_073 -MKLMCVLIVAVLFLTACQLTTA-ET-RDKQEDPVVRSSDEMQ--RSEDPKLAKR -CTDFGGDCD--LDNHDCCS-G-ECFGFPELA---VCT------------- V_1302_104 -MKLTCVLIIAVLFLTACQLTTA-ET-RDKQEDPVVRSSDEMQ--RSEDPKLAKR -CTDFGGDCD--LDNHDCCS-G-ECFGFPELA---VCT------------- V_1278_070 ----------------------------------------------SEDPKLAKR -CSGFGDSCD--PRNHNCCS-D-ECFGIPSEG-FGLCT------------- K_0010_224 -MKLTCVLIVAVLFLTACQLTTADYS-RDKLEDPVVRSSDEVQ--RSEDPKLAKR -CSGFGDGCD--PRNHNCCS-G-ECFGFPSEG-FGLCT------------- arenatusQ9BP83 -MKLTCVLIVALLFLTACQLTTADDS-RDKQEDPLVRSHRKMQ--KSEDPKMAER -CSNFGSDCI--PATHDCCS-G-ECFGF--ED-MGLCT------------- A_0855_115 -MKLTCVMIVAALFLTACQLSTAASFARDKQEYPAVRWSDEMQ--DSKELTLTKK -CTDDGDFCD--PENHNCCS-Q-VCIKRETSG---VCAIVPEY-VNNLC-- A_0855_118 -------------FLTACQLSTAASFARDKQEYPAVRWSDEMQ--DSKELTLTKK -CPGNRVFCD--PENHN---------------------------------- A_0855_119 -MKLTCVMIVAALFLTACQLSTAASFARDKQEYPAVRWSDEMQ--DSKELTLTKK -CTDDSDFCD--PENHNCCS-Q-VCIKEGTTG---VCAIVLERNVNNLF-- V_CG13_202 -------------FLTVCQLSTAASFARDKQEYPAVRWSDEMQ--DSKELTLTKK -CTDDADFCD--PENHN---------------------------------- V_1302_196 -MKLTCVMIVAALFLTACQLSTAASFARDKQEYPAVRWTDEMQ--DSKELTLTKK -CTDDTDFCD--PENHNCCS-K-ICIEEGTRG---VCAIVPV-KVNNLF-- V_1258_089 -MKLTCVMIVAALFLTACQLSTAASFARDKQEYPAVRWTDEMQ--DSKELTLTKK -CTDDTDFCD--PENHNCCS-K-ICIEEGTRG---VCAIVPV-KVNNLF-- A_0885_085 -MKLTCVMIVAALFLTACQLSTAASFARDKQEYPAVRWSDEMQ--DSKELTLTKK -CTDDSDFCD--PENHNCCS-Q-VCIKEGTTG---VCAIVLE-NVNNLF-- A_0520_225 -MKLTCVMIVAALFLTACQLSTAASFARDKQEYPAVRWSDEMQ--DSKELTLTKK -CTDDSDFCD--PENHNCCS-Q-VCIKEGTSG---VCAIVPE-NVRNLF-- A_0048_112 -MKLTCVMIVAALFLTACQLSTAASFARDKQEYPAVRWSDEMQ--DSKELTLTKK -CTDDSDFCD--PENHNCCS-Q-VCIKEGTSG---VCAVVPE-NVRNLF-- A_0239_390 -MKLTCVMIVAALFLTACQLSTAASFARDKQEYPAVRWSNEMQ--DSKELTLTKK -CTDDSDFCD--PENHNCCS-Q-VCIKEGTNG---VCAIVP---------- A_0031_209 -MKLTCVMIVAALFLTACQLSTAASFARDKQEYPAVRWSNEMQ--DSKELTLTKK -CTDDSDFCD--PENHNCCS-Q-VCIKEGTSG---VCAIVPE-YVNNLF-- A_1387_118 -MKLTCVMIVAALFLTACQLSTAASFARDKQEYPAVRWSDEMQ--DSKELTLTKK -CTDDGDFCD--PENHNCCS-Q-VCINEGTSG---VCAIV--------Y-- A_0520_226 -MKLTCVMIVAALFLTACQLSTAASFARDKQEYPAVRWSDEMQ--DSKELTLTKK -CTNSGDFCD--PENHNCCS-Q-VCIKEGTSG---VCAIVRE-YVNKLY-- A_0025_372 ----------------------------------------------------TKK -CTDDSDFCD--PENHNCCS-Q-VCIKEGTSG---VCAIVRE-YVNNLY-- K_0010_424 -MKLTCV-IVAALFLTACQLSAAASHARDKQEYPAVRRSDEKQ--DSEDLTLAKK -CTDDSDFCD--PTSHDCCS-G-ICIDEGGSG---VCAIVPV-EV------ ermineusAXL95563 -------------FLTACQLSTAASFARDKQEYPAVRWSDEMQ--DSKELTLTKK -CTDDSDFCD--PENHN---------------------------------- geographusBAO65663 -MKLTCVMIVAALFLTACQLSTAASFARDKEEYPAVRSSDGMQ--DSKDLTLAKK -CKEQSQFCG--P-NHKCCT-S-TCT----DG---ICPIVPV-TADILY-- V_CG13_116 ----------------ACQLTTADDS-REKQGYSAVRSSDKIQ--DSDYLKLTKR -CADEYDPCE--VGNPNCCE-G-TCYGDEKEA---VCVNV----YDYAFSR V_CG13_117 --------------------------------------------------RLTKR -CADEYDPCE--VGNPNCCE-G-TCYGDEKEA---VCVNV----YDYAFSR V_1302_105 --------------------------------------------------RLTKR -CADEYDPCE--VGNPNCCE-G-TCYGDEKEA---VCVNV----YDYAFSR V_1302_106 --KLTCVLIVAVLFLTACQLTTADDS-REKQGYSAVRSSDKIQ--DSDYLKLTKR -CADEYDPCE--VGNPNCCE-G-TCYGDEKEA---VCVNV----YDYAFSR V_1278_064 --KLTCVVIVAVLFLTACQLTTADDS-REKHGYSAVRSSDKIQ--DSDYLKLTKR -CADEYDPCE--VGNPNCCE-G-TCYGDENEA---VCVNV----YDYAFSW V_1258_087 -MKLTCVVIVAVLFLTACQLTTADDS-REKQGYSAVRSSDKIQ--DSDYLKLTKR -CADEYDPCE--VGNPNCCE-G-TCYGDEKEA---VCVNV----YDYAFSR V_1258_088 --------------------------------------------------RLTKR -CADEYDPCE--VGNPNCCE-G-TCYGDEKEA---VCVNV----YDYAFSR A_0855_043 --------------------------------------------------RLTKR -CADESDPCE--VGNPNCCE-G-TCYGDEKEA---VCVDV---EYDYAVSR A_0855_044 -MKLTCVVIVAVLFLTACQLTTADDS-REKQGYSAARSSDKIQ--DSDYLKLTKR -CADESDPCE--VGNPNCCE-G-TCYGDEKEA---VCVDV---EYDYAVSR A_0885_088 -MKLTCVVIIVVLFLTTCQLTTADDS-REKQGYSAVRSSDKIQ--DSDYLKLTKR -CADENDPCE--VGNPNCCV-G-TCYGDEKEA---VCVDV---EYDYAVSR A_0885_089 --------------------------------------------------RLTKR -CADENDPCE--VGNPNCCV-G-TCYGDEKEA---VCVDV---EYDYAVSR A_0055_211 ------------------------------------------------------- -CADESDPCE--VGNPNCCE-G-TCYGDEKEA---VCVDV---EYDYAVSR A_0039_175 --------------------------------------------------RLTKR -CADESDPCE--VGNPNCCE-G-TCYGDEKEA---VCVDV---EYDYAVSR A_0039_176 -MKLTCVVIVAVLFLTACQLTTADDS-REKQGYSAARSSDKLQ--DSDYLKLTKR -CADESDPCE--VGNPNCCE-G-TCYGDEKEA---VCVDV---EYDYAVSR A_0048_086 --------------------------------------------------RLTKR -CADESDPCE--VGNPNCCE-G-TCYGDEKEA---VCVDV---EYDYAVSR A_1387_119 -MKLTCVLIVAVLFLTACQLTTADDS-REKQGYSAVRSSDKIQ--DSDYLKLTKS -CADENDPCE--VGNPNCCE-G-TCYGDEKEA---VCVDI---EYDYAVSR A_0239_397 -MKLTCVVIVAVLFLTACQLTTADDS-REKQGYSAVRSSDKIQ--DSDYLKLTKR -CADENDPCE--VGNPNCCE-G-TCYGDEKEA---VCVDV---EYDYAVSR A_0031_112 -MKLTCVVIVAVLFLTACQLATADDS-REKQGYSAVRSSDKIQ--DSDYLKLTKR -CADENDPCE--VGNPNCCE-G-TCYGDEKEA---VCVDV---EYDYAVSR A_0025_123 -MKLTCVVIVAVLFLTACQLTTADDS-REKQGYSAVRSSDKIQ--DSDYLKLTKR -CADENDPCE--VGNPNCCE-G-TCHGDEKEA---VCVDV---EYDYAVSR A_0520_253 -MKLTCVLIVAVLFLTACQLTTADDS-REKQGYSAARSSDKIQ--DSDYLKLTKR -CADESDPCE--VGNPNCCE-G-TCYGDEKEA---VCVDV---EYDYAVSR A_0520_254 -MKLTCVVIVGVLFLTACQLTTADDS-REKQGYSAARSSDKIQ--DSDYLKLTKR -CADESDPCE--VGNPNCCE-G-TCYGDEKEA---VCVDV---EYDYAVSR A_0048_087 -MKLTCVVIVAVLFLMACQLTTADDS-REKQGYSAARSSDKIQ--DSDYLKLTKR -CADESDPCE--VGNPNCCE-G-TCYGDEKEA---VCVDV---EYDYAVSR ermineusAXL95677 -MKLTCVLIVAVLFLSACQLITADDS-REKQGYSAVRSSDKIQ--DSDDLKLTKR -CTDGGALCD--PEDHDCC--G-ECLDYGDGT--FLCEIV-----AYAVSR betulinusAMP44709 -MKLTCLLIVAMLFLMACQLITAEYP-RKKQGYSAVRSRDKIQ--RSDYLKLTKR -CTDDGDVCE--IGNHNCCS-G-SCLIYEDGV---VCGLG--AQYQYMVSR V_CG13_120 --------------------------------------------------RLTKR -CTIPGGYCVI-PHHNECCS-G-WCNPSAIIG---QCR------------- V_CG13_119 -MKVTCVLIVAVLFLATCQLITADYS-RDKQENPVERSRIKMK--ITWRPKLTKR -CTIPGGYCVI-PHHNECCS-G-WCNPSAIIG---QCR------------- V_1302_170 -MKVTCVLIVAVLFLATCQLITADYS-RGKQEIPVERSRIKMK--NTWRPKLTKR -CTIPGGYCVI-PHHNECCS-G-WCNPSAIIG---QCR------------- A_0855_052 -MKVTCVLIVAVLFLTACQLITADYS-RDKQENPVERSRIKMK--NTWRPKLTKR -CTIPGGYCVI-PHHNECCS-G-WCDPSAIIG---QCR------------- A_0875_054 -MKVTCVLIVAVLFLTACQLITADYS-RDKQENPVERSRIKMK--NTWRPKLTKR -CTIPGGYCVI-PDHNECCS-G-WCDPSAITG---KCR------------- A_0520_229 -MKVTCVLIVAVLFLTACQLITADYS-RDKQENPVERSRIKMK--NTWRPKLTKR -CTIPGGYCVI-PDHNECCS-G-WCDPSAITG---KCR------------- A_0048_137 -MKVTCVLIVAVLFLTACQLITADYS-RDKQENPVERSRIKMK--NTWRPKLTKR -CTIPGGYCAI-PDHNECCS-G-WCDPSAITG---KCR------------- A_0048_138 --------------------------------------------------RLTKR -CTIPGGYCAI-PDHNECCS-G-WCDPSAITG---KCR------------- distansAGG19136 -MKLTCMVIIAVLFLAACQLIIADYS-RDMQEHPADRSRIKMK--NFRRPTLTKR -CVSPGGVCQ---HKDECCS-D-RCE-QSAIVS--ICKQR----------- A_0048_111 -MKLTCVMIVAALFLTACQLSAAASHARDKQEYPAVRRSDEKQ--DSEDLTLAKK -CTDDSDFCD--PTSHDCCS-G-ICIDEGGSG---VCAIVPV--EV----- A_0520_325 --------------------------ARDKQEYPAVRRSDEKQ--DSEDLTLAKK -CTDDSDFCD--PTSHDCCS-G-ICIDEGGSG---VCAIVPV--EV----- milesAKB91363 -MKLTCVLIVAVLFLTACQLITAANYARDKQEYPAVRSSDEMQ--DSEDLTLTKK -CTDSGQFCD--PTDHDCCS-G-NCIDEGGNG---VCAFVRE--DVPKLY- V_CG13_122 --------IVAVLFLMACQIITADYS-RDKQEHPAERSRIKMK--DFRRPTLTKR -CTDSGDRCI---ASSACCS-R-VCDTQHT-G-PSTCL------------- V_1302_216 -----------------------DYS-RDKQEHPAERSRIKMK--DFRRPTLTKR -CTDSGDRCI---EDSACCS-G-KCDIQHT-G-PSACL------------- V_1258_130 -MKVTCVLIVAVLFLMACQIITADYS-RDKQEHPAERSRIKMK--DFRRPTLTKR -CTDSGDRCI---EDSACCS-G-KCDIQHT-G-PSACL------------- V_1278_013 -MKVTCVLIVAVLFLMACQIITADYS-RDKQEHPAERSRIKMK--DFRRPTLTKR -CTDRGDRCI---ASSACCS-G-KCDIQHT-G-PSACL------------- A_0875_061 ---VTCVLIVAVLFLMACQIITAEYS-RDKQEHPAERSRIKMK--DFRRTTLTKG -CSDPSAPCL---ANSDCCS-H-VCDVQHT-G-PSACH------------- ermineusAXL95342 -----------VLFLTACGLITAEYP-RDKQEHPAERSRLQMK--DFRRPKLSTR -CMSSDSPCL---QGSQCCS-G-VCQIIHI-G-QLACM------------- praecellensATF27674 -MKLTCVLIVAVLFLTACQLITADDS-RDKQEYPAERSRIKRQ--NSKRSMSTKS -CKGPNLACR---RNYHCCS-K-SCKAKSRYN-G-SCQ------------- V_1302_107 -MKLTCTVIIAVLFLTACQLITTDGS-RGKKNLLERMV-ERMR--NSRDSKLAKR -CKPINDPCSP-FEAEECCY---VCEYEGVGRG--WCAYN----------- V_CG13_086 -MKLTCTVIIAVLFLTACQLITTDGS-RGKKNLLERMV-ERMR--NSRDSKLAKR -CKPINDPCSP-FEAEECCY---VCEYEGVGRG--WCAYN----------- V_1258_002 -MKLTCTVIIAVLFLTACQLITTDGS-RGKKNLLERMV-ERMR--NSRDSKLAKR -CKPINDPCSP-FEAEECCY---VCEYEGVGRG--WCAYN----------- betulinusAMP44725 -MKLMYALIIAVLFLTACQLVTTDGF-RGKQNLLERMA-DRMR--DSRNFKLAKR -CKPVNYACSP-SDAEKCCG---VCEYEGIGRG--WCAYS----------- V_CG13_090 -----------VLFLTACQLITADYS-RDKQEYRAVRLRDAIQ--NF---KGS-R SC------------------------------------------------- V_1302_190 -----------VLFLTACQLLTADYS-RDKQEYRAVRLRDAIQ--NF---KGS-R SC------------------------------------------------- V_1258_072 -----------VLFLTACQLITADYS-RDKQEYSAVRLRDAMQ--NF---KGS-R SC------------------------------------------------- A_1387_106 MMKLTCVLIIAVLFLTACQLITADYS-RDKQEYRAVRLRDAMQ--NF---KGS-R SCGNQGTGCTV---DDPCCA-GLTCRGQYAG-G--ICQPV----------- A_0239_145 ----------------------------------------------F---KDS-R SCGKQGKGCT--INGRPCCA-GLTCRGQYAG-G--SCQPV----------- A_0855_042 ----------------------------------------------F---KDS-R SCGKQGKGCT--INGRPCCA-GLTCRGQYAG-G--SCQPV----------- A_0025_371 -MKLTCVLIIAVLFLAACQLITADYS-RDKQEYRAVRLRDAIQ--NF---KDS-R SCGKQGKGCT--INGRPCCA-GLTCRGQYAG-G--SCQPV----------- A_0875_057 -MKLTCVLIVAVLFLTACQLITADYS-RDKQEYRAVRLRDAIQ--NF---KDS-R SCGKQGKGCT--INGRPCCA-GLTCRGQYAG-G--SCQPV----------- V_1258_132 --KLTCVLIVAVLFLTACQLITADYS-RDKQEYRAVRLRDAIQ--NF---KGS-R SCLKKNEDCS--IHSRPCCS-GLTCRGQYAG-G--VCQPV----------- V_1302_187 -MKLTCVLIIAVLFLTACQLLTADYS-RDKQEYRAVRLRDAIQ--NF---KDS-R SCGEQGEGCT--RNGRLCCA-GLTCRGQYAG-G--VCQPV----------- V_CG13_088 -MKLTCVLIIAVLFLTACQLITADYS-RDKQEYRAVRLRDAIQ--NF---KDS-R SCGEQGEGCT--SNGRPCCA-GLTCRGQNAG-G--VCQPV----------- V_1278_067 -MKLTCVLIVAVLFLTACQLITADYS-RDKQEYRAVRLRDAIQ--NF---KGS-R SCLKKNEDCS--IHSRPCCS-GLTCRGQYAG-G--LCRPR----------- V_1258_133 --KLTCVLIVAVLFLTACQLITADYS-RDKQEYRAVRLRDAIQ--NF---KGS-R SCLKKNEDCS--IHSRPCCS-GLTCRGQYAG-G--LCRPR----------- V_1258_135 -------------FLTACQLITADYS-RDKQEYRAVRLRDAIQ--NF---KGS-R SCGEQGEGCA----TRRCCA-GLRCVGGRPG-G--LCQYR----------- A_0875_056 -MKLTCVLIVAVLFLTACQLITADYS-RDKQEYRAVRLRDAIQ--NF---KDS-R SCGQPNERCD----SRPCCR-GQPCIAGIAG-N--LCIEKLSGI------- A_0855_117 MMKLTCVLIIAVLFLTACQLITADYS-RDKQEYRAVRLRDAIQ--NF---KDS-R SCGQPNERCD----SRPCCR-GQPCIVGIAG-N--VCIQK-SGI------- A_0239_202 ----------------------------DKQEYRAVRLRDAIQ--NF---EDS-R SCGQPYERCD----YRPCCP-GRRCIVGFAG-N--VCIQK----------- A_0239_142 -MKLTCVLIIAVLFLTACQLITADYS-RDKQEYRAVRLRDAIQ--NF---KDS-R SCGQPYERCD----YRPC--------------------------------- A_0031_208 -MKLTCVLIIAVLFLTACQLITADYS-RDKQEYRAVRLRDAIQ--NF---KDS-R SCGQPYERCD----YRPCCP-GRRCIVGFAG-N--VCIQK----------- A_0885_152 -MKLTCVLIIAVLFLTACQLITADYS-RDKQEYRAVRLRDAIQ--NF---KDS-R SCGQPYERCD----SRPCCP-AQRCIVGFAG-N--VCIQK----------- A_0055_135 -MKLTCVLIIAVLFLTACQLITADYS-RDKQEYRSVRLRDAIQ--NF---EDS-R WCGQQYESCD----SRPCCP-GKTCIPAIKN-M--ICIQK----------- A_0039_181 -MKLTCVLIIAVLFLTACQLITADYS-RDKQEYRSVRLRDAIQ--NF---EDS-R WCGQQYESCD----SRPCCP-GKTCIPAIKN-M--ICIQK----------- A_0055_139 -MKLTCVF-IAVLFLTACQLITADYS-RDKQEYRAVRLTDAIE--NF---KDS-R WCGQQNESCD----DRPCCP-GKTCIPAVEN-M--ICIQK----------- A_0239_203 --------------LTACQLITADYS-RDKQEYLAVRLRDGIL--NS---KRY-R WPCAKLHYGC---SGRHCCP-GLLCGGGKIQ-A--FCKLE----------- A_0855_116 MMKLTCVLIIAVLFLTACQLITADYS-RDKQEYLAVRLRDGIL--NS---KRYRR SCAKLHCGCS----RRPCCP-GLLCGGGKIQ-A--FCKLE----------- A_0875_058 -MKLTCVLIVAVLFLTACQLITADYS-RDKQEYLAVRLRDGIL--NS---KRYRR SCAKLHCGCS----RRPCCP-GLLCGGGKIQ-A--FCKLE----------- A_0055_134 --------------LTACQLITADYS-RDKQEYLAVRLRDGIL--NS---KRYRW PCAKLHYGCS----GRHCCP-GLLCGGGKIQ-A--FCKLE----------- A_0239_143 -MKLTCVLIIAVLFLTACQLITADYS-RDKQEYRAVRLRDAIQ--NF---KDS-R SCGQQYESCA----TRPCCH-DQSCIVGFAG-K--MCIQN----------- A_0031_207 -MKLTCVLIIAVLFLTACQLITADYS-RDKQEYRAVRLRDAIQ--NF---KDS-R SCGQQYESCA----TRPCCH-DQSCIVGFAG-K--ICIQN----------- A_0239_106 ----TCVLIVAVLFLTACQLTTADYS-RDKQEYHAVRSRHGMR--NS---KGS-R SCSEYREGCA----TQACCG-DLTCVGNPPG-G--MCL------------- A_0855_113 -MKLTCVVIVAVLFLTACQLTTADYS-RDKQEYHAVRSRDGMR--NS---KGS-R SCSEYREGCA----TQACCS-GLMCIGNPPG-G--MCLQN-NDFLAH---- A_0039_132 ----------------ACQLTTADYS-RDKQEYHAVRSRDGMR--NS---KGS-R SCSEYREGCA----TQACCS-GLMCIGNPPG-G--MCLQN-NDFLAH---- A_0055_144 -MKLTCVLIVAVLFLTACQLTTADYS-RDKQEYHAVRSRDGMR--NS---KGS-R SCSEYREGCA----TQACCS-GLMCIGNPPG-G--MCLQN-NDFLAH---- A_1387_116 -MKLTCVLIIAVLFLTACQLTTADYS-RDKQEYHAVRSRDGMR--NS---KGS-R SCSEYREGCA----TQACCS-GLTCVGNPPG-G--MCLQN-SDILAH---- A_0055_145 ----TCVLIVAVLFLTACQLTTADYS-RDKQEYHAVRSRHGMR--NS---KGS-R SCSEYREGCA----TQACCS-GLTCVGNPPG-G--MCIQN-SDILALLFVI A_0239_107 ----TCVLIVAVLFLTACQLTTADYS-RDKQEYHAVRSRHGMR--NS---KGS-R SCSEYREGCA----TQACCS-GLTCVGNPPG-G--MCIQN-SDILALLFVI A_0031_212 --------IIAVLFLTACQLTTADYS-RDKQEYHAVRSRHGMR--NS---KGS-R SCSEYREGCA----TQACCS-GLTCVGNPPG-G--MCIQN-SDILALLFVI A_0031_248 ---------------------------RDKQEYRAVRLRDAIQ--NF---EDS-R WCGQQYESCD----SRPCCP-GKTCIPAIKN-M--MCIQK----------- K_0010_222 -MKLTCVLIVAVLFLTACQLTTAEYS-REKEGYSAVSSSDKIQ------------ --------------------------------------------------- K_0010_367 -MKLTCVLVIAVLFLTACQLITADYS-RDKQEYSAVRLRDAMQ--NF---KGS-R SCGERGEGCY----TRRCCA-GLRCVGSSRG-G--LCQYR----------- K_0010_368 -MKLTCVLVIAVLFLTACQLITADYS-RDKQEYSAVRLRDAMQ--NF---KGS-R SCGEQGEGCA----TRLCCA-GLRCVGSRPG-G--LCQYR----------- ermineusAXL95562 -------------FLTACQLITADYS-RDKQEYRAVRLRDAIQ--NF---KDS-R SCGQPNERCD----SRPCCR-GQPCIVGIAG-N--VCIQK----------- arenatusQ9BP84 -MKLTCVLIIAVLFLIVCQLNTADDS-RDKQEYRAVRLRDAIR--NS---RGS-R SCGNLGESCS----AHRCCP-GLMCMGEAS-----ICIPY----------- arenatusQ9BP87 -MKLTCVLIIAVLFLTACQLITADYS-RDKQEYRAVRLRDAMR--YS---RVR-R QCADLGEECH----TRFCCP-GLRCEDLQV--P--TCLMA----------- flavidusAFU50768 -MKLMCVLIIAVLFLTASQLITADYS-RDKQEYRAERLRDAMG--KF---KGS-R SCGHSGAGCY----TRPCCP-GLHCSGGQAG-G--LCV------------- lividusAAZ83783 -MKLTCVLIIAVLFLTASQLITADYS-RDKQEYGAERLRDAMG--KF---KGS-R SCGHSGAGCY----TRPCCP-GLHCSGGHAG-G--LCV------------- vexillumCAH64851 -MKLTCVLIITVLFLTASQLITADYS-RDQRQYRAVRLGDEMR--NF---KGA-R DCGGQGKGCY----TQPCCP-GLRCRGGGTG-G-GVCQP------------ vexillumQ5K0D1 -MKLTCVLIITVLFLTASQLITADYS-RDQRQYRAVRLGDEMR--TF---KGA-R DCGEQGQGCY----TRPCCP-GLHCAAGATG-G-GSCQP------------ brunenusAFI41817 -MKLTCVLIVALLFLTACQLITADYS-RDDYRAVMG---LGRR--NS---KDS-R DCQESGQGCT---GSPPCCP-GLSCSGTHAG-G--MCVG------------ andremeneziATF27442 -MRLTCVLIVAVLSLTACQLITADYS-RDKQEYLAARFRDGMR--NS---KVS-R ECREYRQGCA----YTPCCP-GLKCRGTNAG-G--MCVKT----------- leopardusAIC77160 -MKLTCMVIIAVLFLTANQHITADHS-RDNLLYRAVRLRDGMR--NF---RGF-R SCSEQGEGCA----TRPCCP-GLNCVGGIAG-G--LCQD------------ praecellensATF27680 -MKLTCVLIVAVLSLTACQLITADYS-RDKQEYLAARFRDGMR--NS---KVS-R ECREYRQGCA----YTPCCP-GLKCRGTHAG-G--MCVKT----------- A_0855_041 -MKLTCVLIVAVLFLTACQLTTA-ET-RDKQEHHAVRLRDAMQ--KF---KGS-R ACSAHRGGCG---ATQACCA-GLRCSGAQSA-G--MCVSV----------- A_1387_113 -MKLTCVLIIAVLFLTACQLTTA-ET-RDKQEHHAMRLRDAMQ--KF---KGS-R ACSAHRGGCG---ATQACCA-GLRCSGAQSA-G--MCVSV----------- A_0875_120 -MKLTCVLIIAVLFLTACQLTTA-ET-RDKQEHNAVRLRDAMQ--KF---KGS-R ACSAHRGGCG---ATQACCA-GLRCSGAQSA-G--MCVSV----------- A_0031_246 --KLTCVLIVAVLFLTACQLTTA-ET-RDKQEHHAARLRDAMQ--KF---KGS-R ACSAHRGGCG---ATRACCA-GLRCSGAQSA-G--VCVSG----------- A_0239_392 -MKLTCVLIIAVLFLTACQLTTA-ET-RDKQEHHAARLRDAMQ--KF---KGS-R ACSAHRGGCG---ATRACCG-GLRCSGAQSA-G--VCVFR----------- A_0055_136 -MKLTCVLIIAVLFLTACQLTTA-ET-RDKQEHHAARLRDAMQ--KF---KGS-R ACSAHRGGCG---ATRACCG-GLRCSGAQSA-G--VCVFR----------- A_0025_368 -MKLTCVLIVAVLFLTACQLTTA-ET-RDKQEHHAVRLRDAMQ--KF---KGS-R ACSAHQEGCG---ATQGCCA-GLRCAGTHAG-G--MCITV----------- A_0025_370 -MKLTCVLIVAVLFLTACQLTTA-ET-RDKQEHHAVRLRDAMQ--KF---KGS-G ACSAHQEGCG---ATQGCCA-GLRCAGTHAG-G--MCITV----------- A_0025_369 -MKLTCVLIVAVLFLTACQLTTA-ET-RDKQEHHAVRLRDAMQ--KF---KGS-R ACSAHREGCG---VTQGCCA-GLRCAGTHAG-G--MCITV----------- V_CG13_166 -MKLTCVLIVAVLFLTACQLTTA-ET-RDKQEHYAMRSRDAMQ--KF---KGS-R ACSEYREGC----ATQPCCS-GLTCRGTRFG-G--MCVHA----------- V_1302_186 -MKLMCVLIVAVLFLTACQLTTA-ET-RDKQEHYAMRSRDAMQ--KF---KGS-R ACSEYREGC----ATQPCCS-GLTCRGTRFG-G--MCVHA----------- V_1258_131 -MKLTCVLIIAVLFLTACQLTTA-ET-RDKQEHYAMRSRDAMQ--KF---KGS-R ACSEYREGC----ATQPCCS-GLTCRGTRFG-G--MCVHA----------- A_0885_041 -MKLTCVLIVAVLFLTACQLTTA-ET-RDKQEHHAVRLRDAMQ--KF---KGS-R ACSVYREGC----ATQACCA-GLQCVGGRSG-G--MCVSG----------- A_0039_174 -----------------------------KQEHHAVRLRDAMQ--KF---KGS-R TCSVYREGC----ATQACCA-GLRCVGTRAG-G--MCISG----------- A_0039_177 -MKLTCVLIVAVLFLTACQLTTA-ET-RDKQEHHAVRLRDAMQ--KF---KGS-R TCSVYREGC----ATQACCA-GLRCVGTRAG-G--MCISG----------- A_0039_179 ----------------------------DKQEHHAVRLRDAMQ--KF---KGS-R TCSVYREGC----ATQACCA-GLRCVGTRAG-G--MCISG----------- A_0520_250 -MKLTCVLIVAVLFLTACQLTTA-ET-RDKQEHHAVRLRHAMQ--KF---KGS-R ACSEYREGC----ATQACCA-GLQCVGGRSG-G--MCVSG----------- A_0048_134 -MKLTCVLIIAVLFLTACQLTTA-ET-RDKQEHHAVRLRDAMQ--KF---KGS-R ACSEYREGC----ATQACCA-GLQCVGGRSG-G--MCVSL----------- A_0048_135 -MKLTCVLIIAVLFLTACQLTTA-ET-RDKQEHHAVRLRDAMQ--KF---KGS-R ACSEYREGC----ATQACCT-GLKCEGTRSG-G--MCVSL----------- A_0520_197 ------------------------------------------------------R ACSEYREGC----ATQACCA-GLQCVGGRSG-G--MCVSG----------- A_0520_251 -MKLTCVLIVAVLFLTACQLTTA-ET-RDKQEHHAVRWRDAMQ--KF---KG--- --------------------------------------------------- ermineusAXL95702 ---------------------TA-ET-RDKQEHHAVRWRDAMQ--KF---KGS-R ACSEYQEGC----ATQACCT-GLQCVGARSG-G--MCVSL----------- ermineusAXL95343 ---LTCVLIVAVMFLTACQLTTA-ET-RDKQEHHAVRLRDAMQ--KF---KGS-R ACSAHREGCG---VTQGCCA-GLRCAGTHAG-G--MCISV----------- A_0039_138 -------------------------------R--AVRSSDKVQ--NS---KST-R DCSVSGDGCK----TRPCCE-GLNCSGPQQG-P--VCT------------- A_0031_245 ----------------------------------AVRSSDKVQ--NS---KST-R DCSVSGDGCK----TRPCCE-GLNCSGPQQG-P--VCT------------- A_0875_119 -MKLTCVLIIAVLFLTACQLTTA-ET-RDVYR--AVRSSDKVQ--NS---KST-R DCSVSGDGCK----TRPCCE-DLNCSGPQQG-P--VCT------------- A_0855_040 -MKLTCVLIIAVLFLTACQLTTA-ET-RDVYR--AVRSSDKVQ--NS---KST-R DCSVSGDGCK----TRPCCE-GLNCSGPQQG-P--VCT------------- V_CG13_113 --------------------TTA-ET-RDVYR--AVRSSDEVQ--NS---KST-R DCSGSGDGCK----TRPCCE-GLTCSGQHQG-P--VCT------------- A_0048_133 -MKLTCVLIIAVLFLTACQLTTA-ET-RDVYR--ALRSSDKVQ--NS---KST-R DCSGSGDGCK----SRPCCE-GLTCSGPRQG-P--VCT------------- V_1302_188 -MKLTCVLIIAVLFLTACQLTTA-ET-RDVYR--AVRSSDEVQ--NS---KST-R DCSQSGDGCK----SRPCCD-GLTCSGPHQG-P--VCT------------- V_1302_191 -MKLTCVLIVAVLFLTACQLTTA-ET-RDVYR--AVRSSDEVQ--NS---KST-R DCSQSGDGCK----SRPCCD-GLTCSGPHQG-P--VCT------------- A_0885_091 MMKLTCVLIVAVLFLTACQLTTA-ET-RDVYR--AVRSSDKVQ--NS---KST-R DCSGSGDGCK----SRPCCN-GLTCYGPKQG-P--VCT------------- A_0055_133 -------LIIAVLFLTACQLTTA-ET-GDEYR--AVRSSDEVQ--NS---KST-R TCSPSGGGCR----TLICCP-GLTCSGPHQA-P--VCH------------- A_0039_137 -------LIIAVLFLTACQLTTA-ET-GDVYR--AVRSSDKVQ--NS---KST-R SCSPSGGGCH----TLICCP-GLTCSGPHQA-P--VCH------------- A_0048_132 -MKLTCVLIIAVLFLTACQLTTA-ET-RDEYR--AVRSSDEVQ--NS---KST-R GCSPSGDGCR----TLTCCP-GLTCSGPHQA-P--VCH------------- A_0025_373 --------------------TTA-ET-RDEYR--AVRSSDEVQ--NS---KST-R GCSPSGDGCR----TLTCCP-GLTCSGPHQA-P--VCH------------- A_0239_201 -------LIIAVLFLTACQLTTA-ET-GDEYR--AVRSSDEVQ--NS---KST-R TCSPSGGGCR----TLICCP-GLTCSGPHQA-P--VCH------------- A_0031_244 --KLTCVLIVAVLFLTACQLTTA-ET-RDVFP--AVRSSDKVQ--NS---KST-R SCSPSGGGCH----TLICCP-GLTCSGPHQA-P--VCH------------- A_0885_090 --KLTCVLIVAVLFLTACQLTTA-ET-RDEYR--AVRSSDKVQ--NS---KST-R GCSPSGDGCR----TLTCCP-GLTCSGPQQA-P--VCH------------- A_0875_059 --KLTCVLIVAVLFLTACQLTTA-ET-RDEYR--AVRSSDEVQ--NS---KST-R GCSPSGDGCR----TLTCCP-GLTCSGPQQA-P--VCH------------- V_CG13_111 -------------FLTACQLTTA-ET-RDEYR--AVRSSDEVQ--NS---KST-R GCSPSGGGCR----TLTCCP-GLTCYGPQQA-P--ICH------------- A_0039_178 -MKLTCVLIVAVLFLTACQLTTA-ET-RDEYR--AVRSSDEVQ--NS---KST-R GCSPSGGGCR----TLTCCP-GLTCYGPQQA-P--ICH------------- V_1258_134 --KLTRVSIIAVLCLTACQLTTA-ET-RDVYR--AVRSSDEVQ--NS---KST-R GCSPSGGGCR----TLTCCP-GLTCYGPQQA-P--ICH------------- A_0031_247 --KLTCVLIVAVLFLTACQLTTA-ET-RDEYR--AVRSSDEVQ--NS---KST-R GCSPSGDGCR----TLTCCP-GLTCSGPQQA-P--VCHESGI--------- A_1387_114 MMKLTCVLIIAVLFLTACQLTTA-ET-RDVFP--AVRWSNKVQ--NS---KST-R NCSPSGGGCR----TCICCP-GLTCSGPQQA-A--VCHTTAI--------- A_0239_391 -MKLTCVLIIAVLFLTACQLVTADDS-RHEYR--AVT-RDKMR--NS---KST-E ECQPSGHGCK----TLTCCP-GLTCSGQSQG-A--VCHSPGK--------- ermineusAXL95587 -------------FLTACQLTTA-ET-RDEYR--AVRSSDEVQ--NS---KST-R GCSPSGDGCR----TLTCCP-GLTCSGPQQA-P--VCH------------- ventricosusAAG60472 MMKLTCVLIIAVLFLTACQLTTA-ET-RDEYR--AVRSSDEVR--NS---RST-R DCSGSGYGCK----NTPCCD-GLTCRGPHQG-P--ICL------------- ventricosusQ9BP93 MMKLTCVLIIAVLFLTACQLTTA-ET-RDEYR--AVRSSDEVQ--NS---RST-D DC--STAGCK----NVPCCE-GLVCTGPSQG-P--VCQPLA---------- V_CG13_200 ------------LFLTACQPITA-AS-YARSEQEHPDVGSSDQ--NS---KLTKR -CLGSNETCW---RDSSCC--SFSCT--NN-----VCF------------- V_1302_189 ------------LFLTACQPITA-AS-YARSEQEHPDVGSSDQ--NS---KLTKR -CLGSNETCW---RDSSCC--SFSCT--NN-----VCF------------- A_1387_123 ----------------ACQLITA-AS-YARSEQEHPDLGSSDQ--NS---KLTKR -CLGRKETCW---NDWSCC--SLICI--SN-----ACGPR----------- A_0239_431 -MKLACVMTVTVLFLTACQLITA-AS-YARSEQEHPDLGSSDQ--NS---KLTKR -CLGRKKTCW---NDWSCC--SLICI--SN-----ACGPR----------- V_1278_063 ------------------------------------------------------- --TPTGGHCT---RHYHCC--SLYCNKLTN-----ECT------------- V_1258_136 -----------------CQLTTA-ET-YARGKQKHRGLRSTDK--NS---RLT-R DCTPTGGHCT---RHYHCC--SLYCNKLTN-----ECT------------- V_1278_068 -MKLTCVLIVAVLFLTACQLTTA-EI-YSSGKQKHRALSSTDK--NS---KLT-R DCIPSGGPCF---KHYHCC--SLICH--IN-----ECM------------- V_1302_109 -MKLTCVLIVAVLFLTACQLTTA-ET-YSSGKQKHRALSSTDK--NS---KLT-R DCIPSGGPCF---KHYHCC--SLIC--HIN-----ECM------------- A_0239_151 -MKLTCVLIVAALFLMACQLTTT-VD--AGGKQKDHDLRSIVK--NS---RLTKS -CKTRGAYCI---DDFECC---EDCDWGRK-----RCT------------- K_0010_223 -MKLTYVLIIAVLFLTACQLTTA-ET-YARGKQKHRGLRSTDK--HS---MLPNS -CTHPGGACF---QPDHCC--GRFCNGITN-----TCHDSPSAV------- K_0010_317 ----------------ACQLTTA-ET-YARGKQKHRGLRSTDK--NS---RLTRD -CTPTGGHCT---RHYHCC--SLFCNKPVN-----ECT------------- abbreviatusAAD48246 ------VLIIAVLFLTACQLTTA-ET-SSRGKQKHRALRSTDK--NS---RMSKR -CTPPGGYCY---HPDPCC--SQYCNFPRK-----HCL------------- aristophanesABO31224 ------VMIVAVLFLTACQLTTA-ET-SSRGKQKHRALRSTDK--NS---RLTKR -CTPPSGYCY---HPYYCC--SRACNLTRK-----RCL------------- miliarisABO31219 ------VLIIAVLFLTACQLTTA-VT-SSRGEQKHRALRSTDK--NS---RLTKR -CTPRNGYCY---YRYFCC--SRACNLTIK-----RCL------------- arenatusQ9BP81 -MKLTCVLIIAVLFLTACQLTTG-ET-YSRGEQKDHALRSTDK--NS---KLT-R QCTPVGGYCF---DHHHCC--SNHCIKSIG-----RCVAH----------- coronatusABO31222 ------VLIIAVLFLTACQLTTA-ET-SSRGKQKHRALRSTYK--NS---RMTKR -CMHPEGGCR---FSYECC--SKICYTPSF-----TCYPS----------- V_CG13_091 -MKLMCALIIAALFLTTCQLITA-AS-YAG--DLRMFPRRKMSDKMQKDKLEKKG -CKADGAWCLLDRHPGQCCNG---CGFF-------WCG------------- A_0055_210 -MKLMCALIIAALFLTTCQLITA-AS-YAGVADLRMFPRRKMSDKMQKDKLEKKG -CKADGDWCLLDRHPGQCCNG---CGFF-------WCG------------- A_0039_173 -MKLMCALIIAALFLTTCQLITA-AS-YAGVADLRMLPRRKMSDKMQKDKLEKKG -CKADGDWCLLDRHPGQCCNG---CGFF-------WCG------------- A_0239_434 -MKLMCALIIAALFLTTCQLITA-AS-YAGVADLRMFPRRKMSDKMQKDKLEKKG -CKADGDWCLLDRHPGQCCNG---CGFF-------WCG------------- A_0031_074 -MKLMCALIIAALFLTTCQLITA-AS-YAGVADLRMLPRRKMSDKMQKDKLEKKG -CKADGDWCLLDRHPGQCCNG---CGFF-------WCG------------- A_0875_137 ------------------------------------FPRRKMSNGMLNAKDMK-D -CLPGKATCNLHD--NKCCNY---CLVF-------WCS------------- A_0855_066 ------------------------------------FPRRKMSNGRLNAKDMK-D -CLPGKATCNLPD--NKCCNY---CLVF-------WCS------------- V_1302_212 ---------------------------------------RKMSDRMLNAKDMKKD -CLPGTAACNLDD--NKCCNY---CLVF-------WCS------------- V_CG13_092 --KLTCVVIVAVLLLTACQLIAT-DD-SR---DLQEFPRRKTSDGMLNAKDMKKD -CLPGTAACNLDD--NKCCNY---CLVF-------WCS------------- V_1278_039 -MKLTCVVIVAVLLLTACQLIAA-DD-SR---DLQEFPRRKMSDGMLNAKDMKKD -CLPGTAACNLDD--NKCCNY---CLVF-------WCS------------- A_0031_075 -MKFACMWIIAVLLLTACQLIAT-DD-SR---DLQEFPRRKMSNGMLNAKDM-KD -CLHGTASCNLYN--NKCCNY---CLVF-------WCS------------- K_0010_188 -MKLTCVLIVAVLLLTA-QLIAT-DD-SR---DLQEFPRRKMDDGMLNTKDAEKR -CLTPTCTCSMEN--DQCCST---CVLF-------LCS------------- arenatusQ9BP91 -MKLTCVLIVAVLFLTACQLIAA-DD-SR---DLKRFSRRKMRDGMLNTKNTKRQ -CLPPLSLCTMDD--DECCDD---CILF-------LCLVTS---------- andremeneziATF27455 -MKLTCVLIVAVLFLTACQLITT-DD-SS---DLQEFPRRKMIDRLLDTKAAQER -CLGGSSPCTAFS--GNCCNY---CAFF-------WCT------------- praecellensATF27685 -MKLTCVLIVAVLFLTACQLITA-DD-SS---DLQEFPRRKMIDRLLNTKAAQER -CLGGSSPCTAFS--GNCCNY---CAFF-------WCT------------- [Superfamily O1-3] [Delta] [Framework VI/VII] [ /----Signal-----------/------------Pro----------------------/ /C------C----------CC---C----C------] A_0039_156 -MKLTCMMIVAMLFLTAWSFVTADDSRNGLEY------LFPKAHYEM-NLEASRLN-KK-W DCIDRFQLCGI-KILG--RCCRNFCFI-IC------- A_0055_045 -MKL----IVAVLFLTAWTFVTADDSRNGLEY------LFPKAHYEM-NPEVSRLN-KK-R DCIDRFQLCGI-KILG--RCCRNFCFI-ICW------ A_0239_386 -MK----LIVAVLFLTAWTFVTADDSRNGLEY------LFPKAHYEM-NPEASRLN-KK-R DCIDRFQLCGI-KILG--RCCRNFCFI-ICW------ A_0239_385 -MK----LIVAVLFLTAWTFVTADDSRNGLEY------LFPKAHYEM-NPEASRLN-KK-W DCIDRFQLCGI-KILG--RCCRNFCFI-ICW------ A_0855_130 -MKL----IVAVLFLTAWTFVTADDSRNGLEY------LFPKAHYEM-NPEASGLN-KK-R DCLPRGHVCGI-NILG--RCCTNMCIL-FCL------ A_0025_285 -MKLTCMMIVAMLFLTAWTFVTADDSRNGLEY------LFPKAHYEM-NPEASRLN-EK-R DCLARGEVCGI-KIRG--RCCSNVCIY-FCL------ A_0855_132 -MKL----IVAVLLLTAWTFVTADDSRNGLEY------LFPKAHYEM-NLEASRLN-KK-S GCLDRGQLCGI-KILG--RCCVNLCLL-VCL------ A_0885_140 -MKL----IIAVLFLTAWTFVTADDSRNGLEY------LSPKAHYEM-NPEASRLN-KK-R DCLDRGQFCGV-KILG--RCCVNLCLL-VCL------ A_0855_133 -------------------FVTADDSRNGLEY------LFPKAHYEM-NPEASRLN-KK-R DCLDRGQVCGV-KILG--RCCVNLCLF-VCL------ A_0055_046 ----------------------ADDSRNGLEY------LFPKAHYEM-NLEASRLN-KK-S DCLDRGQFCGV-KILG--RCCVNLCLL-ICL------ A_0039_154 ----------------------ADDSRNGLEY------LFPKAHYEM-NLEASRLN-KK-S DCLDRGQFCGV-KILG--RCCVNLCLL-ICL------ ermineusAXL95529 -------------------FVTADDSRNGLEY------LFPKAHYEM-NPEASGLN-KK-R DCLDRGQVCGV-KILG--RCCVNLCLF-VCL------ ventricosusQ9BPA2 -MKLTCMMIVAVLFLTAWTFVTADDSRNGLEY------LFPKAHYEM-NPEASKLN-KK-E DCEAGGRFCGF-PKIG-EPCCSGWCFF-VCA------ striatusB2KJ30 -MKLTCMMIVAVLFLTAWTFVTADDSRNGLKN------LFPKARHEMKNPDASKLN-KR-D GCSNAGGFCGI--HPG--LCCSEICLV-WCT------ V_1302_197 -----------------WTFVTADDSRNGLEY------LFPKAHYEM-NPKASR-N-TG-- TCRPSGVVCGF-PKPG-PYCCSGWCLF-VCV------ V_1302_199 -MKRTCMMIVAVLFLTAWTFVTADDSRNGLEY------LFPKAHYEM-NPKASR-N-TG-- TCLADGVFCGF-PKPG-PYCCSGWCLF-VCV------ V_CG13_160 -MKLTCVMIVAVL-LTAWTFVTADDSRNGLEY------LFPKAHYEM-NPKASR-N-TG-- TCRPSGVACGF-PKPG-PYCCSGWCIF-VCV------ V_CG13_164 -MKLTCVMIVAVLFLTAWTFVTADDSRNGLEY------LFPKAHYEM-NPKASR-N-TG-- TCRPSGVACGF-PKPG-PYCCSGWCIF-VCV------ V_1258_096 -MKRTCMMIVAVLFLTAWTFVTADDSRNGLEY------LFPKAHYEM-NPKASR-N-TG-- TCLADGVFCGF-PKPG-PYCCSGWCLF-VCV------ V_1258_098 -MKLTCVMIVAVLFLTAWTFVTADDSRNGLEY------LFPKAHYEM-NPKASR-N-TG-- TCRPSGVVCGF-PKPG-PYCCSGWCLF-VCV------ V_1302_169 -----------------WTFVTADDSRNGLEY------LFPKARHEM-NPKASR-N-TG-- TCRPSGVVCGF-PKPG-PYCCSGWCFV-VCI------ V_1258_093 -----------------WTFVTADDSRNGLEY------LFPKAHYEM-NPKASR-N-TG-- TCRPSGVVCGF-PKPG-PYCCSGWCFV-VCI------ V_CG13_161 -MKRTCVMIVAVLFLTAWTFVTADDSRNGLEY------LFPKARHEM-NPKASR-D-TK-- KCRPGGVVCGF-PKPG-PYCCSGWCFV-VCI------ V_1258_099 -MKLTCVMIVAVLFLTAWTFVTADDSRNGLEY------LFPKAHYEM-NPKASR-N-TG-- TCLADGVFCGF-PKPG-PYCCSGWCFV-VCI------ V_1302_198 -----------------WTFVTADDSRNGLEY------LFPKAHYEM-NPKASR-N-TG-- TCRPSGVVCGF-PKPG-PYCCSGWCFI-VCF------ V_CG13_162 -MKLTCVMIVAVL-LTAWTFVTADDSRNGLEY------LFPKARHEM-NPKASR-D-TK-- KCRPGGVVCGF-PKPG-PYCCSGWCFI-VCF------ V_1302_200 -MKRTCMMIVAVLFLTAWTFVTADDSRNGLEY------LFPKAHYEM-NPKASR-N-TG-- TCLADGVFCGF-PKPG-PYCCSGWCFI-VCF------ A_1387_108 -MKLTCMTIVAVLFLTASIFITADDSRNGFEN------LPRKRRHEMMNPKASKLN-KR-- DCRAEGEICD--PVAE-LPCCDGWCFI-VCL------ magusQFQ61072 -MKLTCMMIVAVLFLTAWTFATADDPRNGLGN------LFSKAHHEMKNPKDSKLN-KR-- -CLDAGEMCDL-FN---SKCCSGWCIILVCA------ marmoreusADZ74147 -MKLTCMMIVAVLFLTAWTFAAADDPRNGLEN------LFSKAHHEMKNPKDSKLN-KR-- -CLDAGEMCDL-FN---SKCCSGWCIILVCA------ andremeneziATF27459 -MKLTCMMIVAVLFLTTWVFITADDSRNGLEN------LPRMARHEIKNPEASKLN-NRDD DCVAGGQGCGF-PKIG-GPCCSGWCFI-VCT------ praecellensATF27702 -MKMTCMMIVAVLFLTTWTFVTADDSRSGLEI------LFPKARHEMKNPKASKLD-NRND ECVAGGQACGF-PKVG-GPCCSGYCAF-ACL------ A_0885_137 -MKLTCMMIVAVLFLTAWSFVTADDSTYGLAN------IFTKARDEIKNPEDPKLD-NE-K RCFQTGEFCIP-PITGSVFCCDNVCFF-VCL------ A_0039_152 -MKLTCMMIVAMLFLTAWSFVTADDSTYGLAN------IFTKARDEIKNPEDPKLD-NE-K RCFQTGEFCIP-PITGSVFCCDNVCFF-VCL------ A_0055_162 -MKLTCLMIVAVLFLTAWSFVTADDSTYGLAN------IFTKARDEIKNPEDPKLD-NE-K RCFQTGEFCIP-PITGSVFCCDNVCFF-VCL------ A_0855_135 -MKLTCVMIVAVLFLTAWSFVTADDSTYGLAN------IFTKARDEIKNPEDPKLD-NE-K RCFQTGEFCIP-PITGSVFCCDNVCFF-VCL------ A_0875_083 -MKLTCMMIVAVLFLTAWTFVTADDSTYGLAN------IFTKARDEIKNPEDPKLD-NE-K RCFQTGEFCIP-PITGSVFCCDNVCFF-VCL------ A_0520_245 -MKLTCMMIVAVLFLTAWSFVTADDSTYGLAN------IFTKARDEIKNPEDPKLD-NE-K RCFQTGEFCIP-PITGSVFCCDNVCFF-VCL------ A_0025_284 -MKLTCMMIVAVLFLTAWSFVTADDSTYGLAN------IFTKARDEIKNPEDPKLD-NE-K RCFQTGEFCIP-PITGSVFCCDNVCFF-VCL------ A_0048_204 -MKLTCMMIVAMLFLTAWTFVTADDSTYGLAN------IFTKARDEIKNPEDPKLD-NK-K RCFQTGEFCIP-PITGSVFCCDNVCFF-VCL------ A_1387_266 -MKLTCMMIVAVLFLTAWSFVTADDSTYGLAN------IFTKARDEIKNPEDPKLD-NK-K RCFQTGEFCIP-PITGSIFCCDNVCFF-VCL------ A_0239_173 -MKLTCMMIVAVLFLTAWSFVTADDSTYGLAN------IFTKARDEIKNPEDPKLD-NK-K RCFQTGEFCIP-PITGSVFCCDSVCFF-VCL------ A_0031_329 -MKLTCMMIVAVLFLTAWSFVTADDSTYGLAN------IFTKARDEIKNPEDPKLD-NK-K RCFQTGEFCIP-PITGSVFCCDSVCFF-VCL------ V_CG13_343 -------MIVAVLFLTAWTFVTADDSINGLEN------RFSKARDEMKNAEASELD-KK-- ACLEQGEFCGV-VIVGLLACCSSICLV-LCL------ V_1302_328 -MKLTCMMIVAMLFLTAWTFVTADDSINGLEN------RFSKARDEMKNAEASELD-KK-- ------------------------------------- A_0855_134 -MKLTCMMIVAMLFLTAWTFVTADDSINGLEN------RFSKARDEMKNAGASELD-KK-- SCLADGEFCGF-LVVKYFKCCDGVCLV-VCV------ V_CG13_140 -----------------WTFVTADDSINGLEN------RFSKARDEMKNAEASELD-KK-- SCLADGEFCGF-LVVKYFKCCDGVCLV-VCV------ V_1278_060 -MKLTCMMIVAMLFLTAWTFVTADDSINGLEN------RFSKARDEMKNAEASELD-KK-- SCLADGEFCGF-LVVKYFKCCDGVCLV-VCV------ V_1258_101 -MKLTCMMIFAMLFLTAWTFVTADDSINGLEN------RFSKARDEMKNAEASELD-KK-- SCLADGEFCGF-LVVKYFKCCDGVCLV-VCV------ A_0885_083 -MKLTCMMIVAMLFLTAWTFVTADDSINGLEN------RFSKARDEMKNAGASELD-KK-- SCLADGEFCGF-LVVKYFKCCDGVCLV-VCV------ A_0875_086 -MKLTCMMIVAMLFLTAWTFVTADDSINGLEN------RFSKARDEMKNAGASELD-KK-- SCLADGEFCGF-LVVKYFKCCDGVCLV-VCV------ A_0055_159 -MKLTCMMIVAMLFLTAWTFVTADDSINGLEN------RFSKARDEMKNAGASELD-KK-- SCLADGEFCGF-LVVKYFKCCDGVCLV-VCV------ A_0039_150 -----------------WTFVTADDSRNGLEN------RFSKARDEMKNAGASELD-KK-- SCLADGEFCGF-LVVKYFKCCDGVCLV-VCV------ A_0520_244 -MKLTCMMIVAMLFLTAWTFVTADDSINGLEN------RFSKARDEMKNAGASELD-KK-- SCLADGEFCGF-LVVKYFKCCDGVCLV-VCV------ A_0239_348 -----CMMIVAMLFLTAWTFVTADDSINGLEN------RFSKARDEMKNAGASELD-KK-- SCLADGEFCGF-LVVKYFKCCDGVCLV-VCV------ A_0048_203 -MKLTCMMIVAMLFLTAWTFVTADDSINGLEN------RFSKARDEMKNAGASELD-KK-- SCLADGEFCGF-LVVKYFKCCDGVCLV-VCV------ A_0031_330 -MKLTCMMIVAMLFLTAWTFVTADDSINGLEN------RFSKARDEMKNAGASELD-KK-- SCLADGEFCGF-LVVKYFKCCDGVCLV-VCV------ A_0025_281 -MKLTCMMIVAMLFLTAWTFVRADDSINGLEN------RFSKARDEMKNAGASELD-KK-- SCLADGEFCGF-LVVKYFKCCDGVCLV-VCV------ A_1387_264 -MKLTCMMIVAVLFLTAWTFVTADDSINGLEN------RFSKARDEMKNAGASELD-KK-- SCLANGEFCGF-LVVKYFKCCDGVCLV-VCV------ A_0239_172 -MKLTCMMIVAMLFLNAWTFVTADDSKDGLEN------LFLKARDEMENPEASKLD-KK-- SCFEQGEFCGL-GIVGLFVCCSSICLFHVCL------ A_0025_282 -MKLTCMMIVAMLFLTAWTFVRADDSINGLEN------LFLKARDEMENPEASKLD-KK-- ECFEQGEYCGF-VIVGLFVCCSSVCVFHVCV------ A_0239_174 -MKLTCMMIVAMLFLNAWTFVTADDSKDGLEN------LFLKARDEMENPEASKLD-KK-- ACLEQGEFCGF-VIVGLFACCSKVCLFHVCV------ A_0885_082 -MKLTCMMIVAMLFLTAWTFVTADDSINGLEN------LFLKARDEMENPEASKLD-KK-- ECFEQGEYCGF-VIVGLFVCCSSVCVFHVCV------ A_0855_051 -MKLTCMMIVAMLFLNALTFVTADDSKDGLEN------LFLKARDEMENPEASKLD-KK-- ECLELGEYCGF-VIVGLFVCCSSVCVFHVCV------ V_CG13_121 -MKLTCMMIVAMLFLNAWTFVTADDSKDGLEN------PFLKARDEMENPEFSKLD-KK-- ACLEQGEFCGF-VIVGLFACCSRVCLLHVCV------ V_1278_061 -MKLTCMMIVAMLFLNAWTFVTADDSKDGLEN------PFLKARDEMENPEFSKLD-KK-- ACLEQGEFCGF-VIVGLFACCSRVCLLHVCV------ V_1302_172 --------IVAVLFLNAWTFVTADDSRDGLEN------LFLKARDEMENPDFSKLD-KK-- ACLEQGEVCGF-VIVGLFACCSGVCLLHVCV------ V_1302_173 --------IVAMLFLNAWTFVTADDSRDGLEN------LFLKARDEMENPDFSKLD-KK-- ACLEQGEVCGF-VIVGLFACCSGVCLLHVCV------ V_1258_097 --------IVAVLFLNAWTFVTADDSRDGLEN------LFLKARDEMENPEFSKLD-KK-- TCLEQGEVCGF-VIVGLFACCSGVCLLHVCV------ A_0055_049 -----------------------------------------------------RLD-KK-- TCLANGEFCGL-LLVGYFKCCDGVCLV-VCV------ A_0055_048 -MKLTCMMIVAMLFLNAWTFVTADDSKDGLEN------LFLKARDEMENPEASKLD-KK-- TCLANGEFCGL-LLVGYFKCCDGVCLV-VCV------ A_0239_175 -MKLTCMMIVAMLFLNAWTFVTADDSKDGLEN------LFLKARDEMENPEASKLD-KK-- TCLANGEFCGL-LLVGYFKCCDGVCLV-VCV------ A_0055_047 -MKLTCMMIVAMLFLNAWTFVTADDSKDGLEN------LFLKARDEMENPEASKLD-KK-- ACLERGKFCGT-LLIGYFACCSQVCLV-VCV------ A_0875_088 -MKLTCMMIVAMLFLTAWTFVTADDSINGLEN------LFLKARDEMENPEASKLD-KK-- ECLELGAFCST-LIDGLIVCCSRVCFFYFCL------ A_0875_090 -MKLTCMMIVAVLFLTAWTFVTADDSINGLEN------LFLKARDEMENPEASKLD-KK-- ECLELGAFCST-LIDGLIVCCSRVCFFYFCL------ A_0520_246 -MKLTCMMIVAMLFLTAWTFVTADDSINGLEN------LFLKARDEMENPEASKLD-KK-- ECLELGDFCST-LIDGLIVCCSRVCFFHFCL------ A_0031_332 -MKLTCMMIVAMLFLNAWTFVTADDSKDGLEN------LFLKARDEMENPEASKLD-KK-- ECLELGDFCST-LIDGLIVCCSRVCFLHFCL------ A_0885_081 -MKLTCMMIVAVLFLTAWTFVTADDSKNGLEN------HFWKARDEMKNREASKLD-KK-D DCIKPYGFCSL-PILKNGLCCSGACIG-FCADLR--- A_1387_105 ----------AMLFLTAWPFVTADDSKNGLEN------HFWKARDEIKNREASKLD-KK-D DCIKPYGFCSL-PILKNGLCCSGACIG-FCADLR--- A_0025_231 -MKLTCVMIVAVLFLTAWTFVTADVSKNGLEN------HFWKARDEIKNREASKLD-KK-Y DCVKPYGFCSI-PILKNGLCCSGACIG-FCADLR--- A_0039_159 ---------------TAWTFVTADDSKNGLEN------HFWKARDEIKNREASKLD-KK-Y DCVKPYGFCSI-PILKNGLCCSGACVG-FCADLR--- V_1278_057 -MKLTCMMIVAMLFLTAWTFVTADDSKNGLEN------HFWKARDEIKNREASKLD-KK-Y DCVKPYGFCSI-PILKNGLCCSGACVG-VCADLR--- V_1278_062 -------MIVAVLFLTAWTFVTADDSKNGLEN------HFWKARDEIKNREASKLD-KK-D DCIKPYGFCSL-PILKNGLCCSGACVG-VCADLR--- A_0025_230 -MKLTCVMIVAVLFLTAWTFVTADVSKNGLEN------HFWKARDEIKNREASKLD-KK-D DCIKPYGFCSL-PILKNGLCCSGACVG-VCADLR--- ermineusAXL95470 -MKLTCVMIVAVLFLTAWTFVTADDSKNGLEN------HFWKARDEMKNREASKLD-KK-D DCIKPYGFCSL-PILKNGLCCSGACVG-VCADLR--- A_0031_123 ------------------------EPEDELEN------LFPKARHEM-DPEASELN-KK-Q DCLAGSQICGA-PKIG-PTCCSGFCFF-VCL------ A_0039_149 --------IVAVLFLTAWTFVTADDSRNELEN------LFPKARHEM-DPEASELN-KK-Q DCLAGSQICGA-PKIG-PTCCSGFCFF-VCL------ A_0855_131 -MK----LIVAVLFLTAWTFVTADDSRNELEN------LFPKARHEM-DPEASELN-KK-Q DCLAGSQFCGF-PKIG-PTCCSGWCLF-VCL------ A_0885_142 -MK----LIIAVLFLTAWTFVTADDSRNELEN------LFPKARHEM-DPEASELN-KK-Q DCLAGSQLCGA-PKIG-PTCCSGWCLL-VCL------ A_0875_091 -------------------FVTADDSRNELEN------LFPKARHEM-DPEASELN-KK-Q DCLAGSQLCGA-PKIG-PTCCSGWCLL-VCL------ A_0031_124 ----------------------------ELEN------LFPKARHEM-DPEASELN-KK-R DCIAGGQACGA-PKFG-PPCCSGWCIF-VCV------ A_0025_233 -MK----LIVAVLFLTAWTFVTADDSRNELEN------LFPKARHEM-DPEASELN-KK-H DCLAGSQFCGA-PKIG-PTCCSGWCMF-ACL------ ermineusAXL95353 -------------------FVTADDSRNELEN------LFPKARHEM-DPEASELN-KK-H DCLAGSQFCGA-PKIG-PTCCSGWCMF-ACL------ V_CG13_159 ----------AVLFLTARTSVMADDSKNGLEN------LFSKARDEMKNFEASTLDEKK-- SCLANGEVCVA-PIFANFICCDGLCLFVCVA------ V_1302_145 ----------AVLFLTARTSVMADDSKNGLAN------LFSKARDEMKNFEASTLDEKK-- SCLADGEVCVA-PIFANFVCCDGLCLFVCVA------ V_CG13_163 -MKLTCVMIVAVLFLTAWTFVTADDSRYELEN------LFSKARDEMKNPEASTSDEKK-- ACLGTGEICVV-PFVAGFVCCSGLCLVLCS------- V_1302_146 -MKRTCVMIVAVL-LTAWTFVTADDSRYKLEN------LFSKARDEMKNPEASTSDEKK-- ACLGTGEICAV-PFVAGFVCCSGLCLVLCS------- V_1258_094 ---------------------------------------------EMKNPEASTSDEKK-- ACLGTGEICAV-PFVAGFVCCSGLCLVLCS------- A_0039_158 ----TCMMIVAVLFLTARTSVMADDSKNGLEN------LFSKARDELKNFEASTLDEKK-- ACLEDGELCV--------------------------- A_0048_207 -MKLTCMMIVAILFLTARTSVMADDSKNGLEN------LFSKARDEMKNFEASTLDEKK-- ACLEDGALCV--------------------------- K_0010_189 ----------------------------GLEN------RFSKARDEIENPKASKLVKKE-- -CLANGEFCGA-PAVAFFLCCSMVCIVVCL------- A_0885_138 ---------------------------NEPENRRLWEKLVSKTRDEMKNPEASELS-KK-- QCGDDGQFCFL-PGLG-LNCCSGLCII-VCVPT---- A_0855_148 ----------------------------EPENRRLWEKLVSKTRDEMKNPEASELS-KK-- QCGTDGQFCFL-PGLG-LNCCSGLCLI-VCVPT---- V_CG13_158 -----------------WTFVTADDSINEPENRRLWEKLVSKTRDEMKNPEASKLN-KK-- ECAADGQFCFL-PGLE-LNCCSGICLI-VCVPT---- V_1302_148 -----------------WTFVTADDSINEPENRRLWEKLVSKTRDEMKNPEASELN-KK-- ECGADGQFCFL-PGLG-LNCCSGLCLI-VCVPT---- V_1278_058 -----------------WTFVTADDSINEPENRRLWEKLVSKTRDEMKNPEASELN-KK-- ECGADGQFCFL-PGLG-LNCCSGLCLI-VCVPT---- V_1258_092 -----------------WTFVTADDSINEPENRRLWEKLVSKTRDEMKNPEASKLN-KK-- ECAADGQFCFL-PGLE-LNCCSGICLI-VCVPT---- A_0885_139 -MKLTCILIVAVLFLTAWTFVTADDPRDEPENRRLWEKLVSKTRDEMKNPEASELT-KK-- QCGADGQFCFL-PGLG-LNCCSGLCII-VCVPT---- A_0875_085 -MKLTCMMIVAVLFLTAWTFVTADDSINEPENRRLWEKLVSKTRDEMKNPEASELT-KK-- QCGADGQFCFL-PGLG-LNCCSGLCII-VCVPT---- A_0875_089 -MKLTCILIVAVLFLTAWTFVTADDPRDEPENRRLWEKLVSKTRDEMKNPEASELT-KK-- QCGADGQFCFL-PGLG-LNCCSGLCII-VCVPT---- A_0055_158 ----------------------------EPENRRLWEKLVAKTRDEMKKPEASELS-KK-- QCGADGQFCFL-PGLG-LNCCSGLCVI-VCVPT---- A_0055_161 -MKLTCILIVAVLFLTAWTFVTADDPRDEPENRRLWEKLVAKTRDEMKNPEASELT-KK-- QCGADGQFCFL-PGLG-LNCCSGLCVI-VCVPT---- A_0039_147 ----------------------------EPENRRPWEKLVSKTRDEMKKPEASELS-KK-- QCGADGQFCFL-PGLG-LNCCSGLCVI-VCVPT---- A_0039_157 -------LIVAVLFLTAWTFVTADDPRDEPENRRPWEKLVSKTRDEMKNPEASELT-KK-- QCGADGQFCFL-PGLG-LNCCSGLCVI-VCVPT---- V_1258_100 -MKLTCILIIAVLFLTAWTFVTADDSINGPENRRIWEKLLSKTRDEMKNPEASKLN-KK-- ECAADGQFCFL-PGLE-LNCCSGICLI-VCVPT---- V_CG13_157 -MKLTCILIIAVLFLTAWTFVTADDSINGPENRRIWEKLLSKTRDEMKNPEASKLN-KK-- ECAADGQFCFL-PGLE-LNCCSGICLI-VCVPT---- V_1302_201 -MKLTCLMINAVLFLTAWTFVTADDSINGPENRRIWEKLLSKTRDEMKNPEASKLN-KK-- ECAADGQFCFL-PGLE-LNCCSGICLI-VCVPT---- A_1387_265 -MKLTCMMIVAVLFLTAWTFVTADDSINEPENRRLWEKLVSKTRDEMKNPEASELT-KK-- QCGADGQFCFL-PGLG-LNCCSGLCII-VCVPT---- A_0031_334 -MKLTCILIVAVLFLTAWTFVTADDPRDEPENRRLWEKLVSKTRDEMKNPEASELT-KK-- QCGADGQFCFL-PGLG-LNCCSGLCII-VCVPT---- A_0048_206 -MKLTCILIVAVLFLTAWTFVTADDPRDEPENRRLWEKLVSKTRDEMKNPEASELT-KK-- QCGADGQFCFL-PGLG-LNCCSGLCVI-VCVPT---- A_0025_235 -MKLTCMMIVAMLFLTAWTFVTADDPRDEPENRRLWEKLVSKTRDEMKNPEASELT-KK-- QCGADGQFCFL-PGLG-LNCCSGLCVI-VCVPT---- A_0520_141 -MKLTCILIVAVLFLTAWTFVTADDPRDEPENRRLWEKLVSKTRDEMKNPEASELS-KK-- QCGADGQFCFL-PGLG-LNCCSGLCII-VCVPT---- A_0025_236 -MK----LIVAVLFLTAWTFVTADDPRDEPENRRLWEKLVSKTRDEMKNPEASELT-KK-- QCGADGQFCFL-PGLG-LNCCSGLCVI-VCVPT---- A_0239_177 ------------------------------------EKLVAKTRDEMKNPEASELT-KK-- QCGTDGQFCFL-PGLG-LNCCSGLCII-VCVPT---- A_0031_331 -------------------------------------------------PEASKLT-KK-- QCGADGQFCFL-PGLG-LNCCSGNCMI-VCVPV---- A_0025_234 -MKLTCILIVAVLFLTAWTFVTADDPRDEPENRRLWEKLVSKTRDEMKNPEAPRL--ID-- ECGADGAFCFL-PGLG-LNCCSGLCLI-VCVST---- K_0010_190 -MKLTCMMIVAVLFLTAWTFVTADDSINGPENTRIWQKLLSKTRDEMKNPEGSKLN-KK-- QCGADGQFCFL-PGLG-LNCCSGLCLI-VCVPT---- ermineusAXL95454 -MKLTCMMIVAVLFLTAWTFVTADDPRDGLENRRVWGKLLSMTRDEMKNPEAPRL--ID-- ECGADGAFCFL-PGLG-LNCCSGLCLI-VCVST---- ventricosusQ9BPA0 -MKLMCMMIVAVLFLTAWTFVTADDSINGPENRRIWEKLLSKTRDEMKNPEASKLN-KK-- ECRQPGEFCF--PVVA--KCCGGTCLV-ICI------ betulinusM9PQ91 -MKLTCMVIVAVLFLTAWTSVMADGSINRPDIAEGWQKFFSKARDEMKNRAASELN-KR-- -CAGIGSFCGL-PGLV--DCCSGRCFI-VCLP----- A_0048_205 -MKLTCILIVAVLFLTAWTFVTADDPRDEPENRRLWEKLVSKTRDEMKKPEAFKLN-KK-- KCR---------------------------------- A_0055_160 -MKLTCMMIVAVLFLTAWTFVTADDSINEPENRRLWEKLVAKTRDEMKKPEAFKLN-KK-- KCRPGEELCSI-PL----------------------- A_0039_153 -------LIVAVLFLTAWTFVTADDSRNEPENRRLWEKLVAKTRDEMKKPEAFKLN-KK-- KCRPGEELCSI-PL----------------------- A_0025_237 ------------------------------ENRRLWEKLVAKIRGKMKKPEASELN-KK-- KCRPGEELCSI-PL----------------------- A_0875_084 -MKLTCMMIVAVLFLTAWTFVTADDSINEPENRRLWEKLVAKIRGKMKKPEAFKLN-KK-- KCRPGEELCSI-LL----------------------- A_0855_251 ------------------------------------------ARDEMKNREASKLN-ER-- GCLEVGKFCGIPFVKNW-LCCSQNCLS-FCAPKY--- A_0885_084 --------------LTAWTFVKADDPRDGPDTAGGWEKLFSEARDEMKNREASKLN-ER-- DCFGDKQICGLPLFKNR-LCCSGFCFF-VCIPEY--- A_0048_202 --------------LTAWTFVKADDPRDGPDTAGGWEKRFSEARDEIKNREASKLN-ER-- DCFGVYEFCGT-PFVNNGLCCSGLCIF-VCVPEY--- A_0520_228 -MKLTCVMIVAVLFLTAWTFVKADDPRDGSDTAGGWGKLFSEARDEMKNREASKLN-ER-- GCLEVGEFCGT-PLIKNGLCCSQICLS-VCVPEY--- A_1387_109 -MKLTCILIVAVLFLNAWTFVTADDPKDGPDTAGGWGKLFSEARDEMKNREASKLN-ER-- DCFGVYEFCGT-PFVNNGLCCSGLCIL-VCVPEY--- A_1387_110 -MKLTCILIVAVLFLNAWTFVTADDPKDGPDTAGGWGKLFSEARDEMKNREASKLN-ER-- DCHKVGHFCGT-PLINNGLCCSQNCYL-FCAPEY--- V_1278_059 ------VMIVAVLFLTAWTFVTADDPRDGPDTAVGWRKLFSEARDEMKNREASKLN-ER-- GCIGDVKYCGMVPFANNGVCCSHLCIF-VCVPKAALA V_CG13_141 ------------------TFVTADDPRDGPDTAVGWRKLFSEARDEMKNREASKLN-ER-- GCIGDKKYCGILPFANSGLCCSHLCIF-VCIPKA--- V_CG13_142 --------------------------RDGPDTAGGWGKLFSEARDEMKNREASKLN-ER-- GCIGDKKYCGILPFANSGLCCSHLCIF-VCIPKA--- V_1302_147 ---LTCMMIVAMLFLTAWTFVTADDPRDGPDTAVGWRKLFSEARDEMKNREASKLN-ER-- GCIEDKKYCGILPFANSGVCCNHLCIF-VCVPKA--- V_1258_095 -MKLTCVMIVAVLFLTAWTFVTADDPRDGPDTAVGWRKLFSEARDEMKNREASKLN-ER-- GCIEDKKYCGILPFANNGVCCNHLCIF-VCVPKA--- ventricosusQ9BPA1 -MKLTCVMIVAVLFLTAWTFVTADDPRDGPDTAVGWRKLFSEARDEMKNREASKLN-ER-- GCIEDKKYCGILPFANSGVCCSYLCIF-VCVPKAP-- amadisAYP73032 -M---CILIVAVLFLTAWTFVMADDPRDEPDTVVRGGKLFSRARDEM-NPAASKLN-ER-- DCVEVDYFCGI-PFVFNGLCCSGNCVF-VCTPQG--- pennaceusP56712 -MKLTCMMIIAVLFLTAWTFVMADDPRDEPE-----------ARDEM-NPAASKLN-ER-- GCLEVDYFCGI-PFANNGLCCSGNCVF-VCTPQGK-- [Superfamily O1-4] [Delta] [Framework VI/VII] [ /----Signal--------/------Propre---------/------------C------C--------CC---C--------C--] A_0875_249 -MKLTCVVIVSVLLLTACQFNTADGSRDELRGPLVRLFNKKHDSGGH--RVHNEC--------------------------------- V_CG13_087 ----------------------ADDSRDKLRGPLVRLFNKKHDSMGP--RVHNECVIYGNMCG-EDMTTKCC-YRCED----GMCVT- V_1302_167 -MKLTCVVIVSVLLLTACQLNTADDSREKLRGPLVRLFKKKHDSMGP--RVHNECVIYGNMCG-EDMTTKCC-YKCED----GICVT- V_1278_069 -MKLTCVVIVSVLLLTACQLNTADDSRDKLRGPLVRLFNKKHDFMGH--RVHNECVIYGNMCG-EDMTTKCC-YKCED----GICVT- K_0010_225 -MKLTCVLIVAVLLLTACQLNTAD-SRDKLGGPLARLFNKKQNSPDS--ESHDTCVLFGSICG-EGMSTKCC-YRCDSQS--DMCVS- A_0855_039 -MKLTCVVIVSVLLLTACQFNTADGSRDELRGPLVRLFNKKHDSGGH--RVHNECVLFGSMCG-ADMTPKCC-YRCED----GVCVT- A_0885_077 -MKLTCVVIVSVLLLTACQFNTADGSRDELRGPLVRLFNKKHDSGGH--RVHNECVLFGSMCG-ADMTPKCC-YRCED----GVCVT- A_0055_131 -MKLTCVVIVSVLLLTACQFNTADGSRDELRGPLVRLFNKKHDFGGD--RVHNECVQFGSMCG-ADMVTKCC-YRCED----GMCVS- A_0039_182 -MKLTCVVIVSVLLLTACQFNTADGSRDELRGPLVRLFNKKHDFGGD--RVHNECVQFGSMCG-ADMVTKCC-YRCED----GMCVS- A_0239_235 -MKLTCVVIVSVLLLTACQFNTADGSRDELRGPLVRLFNKKHDFGGD--RVHNECVQFGSMCG-ADMVTKCC-YRCED----GMCVS- A_0520_221 -MKLTCVVIVSVLLLTACQFNTADGSRDELRGPLVRLFNKKHDSGGH--RVHNECVLFGSMCG-ADMTTKCC-YRCED----GTCVS- A_0048_088 -MKLTCVVIVSVLLLTACQFNTADGSRDELRGPLVRLFNKKHDSGGH--RVHNECVLFGSMCG-ADKTTKCC-YRCED----GMCVS- A_0031_211 -MKLTCVVIVSVLLLTACQFNTADGSRDELRGPLVRLFNKKHDSGGH--RVHNECVLFGSMCG-ADKTTKCC-YRCED----GMCVS- A_0025_120 -MKLTCVVIVSVLLLTACQFNTADGSRDELRGPLVRLFNKKHDSGGH--RVHNECVLFGSMCG-ADKTTKCC-YRCED----GMCVS- A_1387_121 -MKLTCVVIVSVLLLTACQFNTADGYRDELRGPLVRLFNKKHDSGGH--RVHNECVLFGSLCG-ADMTTKCC-YRCED----GMCVS- A_0025_121 -------------------------------------------------RVHNECVLFGSMCG-ADKTTKCC-YRCED----GMCVS- V_CG13_089 ----------------------ADDSRDKLGGPSVRLFNKKEIPPAA--LLEHTCAIYRHKCS-EGSAKVYC-IGCNFLS--DKCVS- V_1302_168 ----------------------ADDSRDKLGGPSVRLFNKKEIPPAA--LLEHTCAIYRHKCS-EGSAKVYC-IGCNFLT--DKCVS- A_0520_222 --------------------------------------------PLD--RLETICAIYRHKCS-EGSSKMYR-LRCYFLS--GKCDS- A_0055_132 -MKLTCVVIVSVLLLTACQFNTADGSRDKLGGPSVRLFNKKETPPAS--LLETICAIYRHKCS-EGSSKMYR-LRCYFLS--GKCDS- A_0885_079 -MKLTCVVIVSVLLLTACQFNTADGSRDKLGGPSVRLFNKKETPPAS--LLETICATYRHRCS-EGSSKMYR-LRCDFLS--GKCDS- A_0875_121 -MKLTCVVIVSVLLLTACQFNTADGSRDELRGPLVRLFNKKETPPAS--LLETICATYRHRCS-EGSSKMYR-LRCDFLS--GKCDS- A_0239_233 -MKLTCVVIVSVLLLTACQFNTADGSRDKLGGPSVRLFNKKETPPAS--LLETICAIYRHKCS-EGSSKMYR-LRCDFLS--GKCDS- A_0031_210 -MKLTCVVIVSVLLLTACQFNTADGSRDKLGGPSVRLFNKKETPPAS--LLETICAIYRHRCS-EGSSKMYR-LRCDFLS--GKCDS- A_0025_119 -MKLTCVVIVSVLLLTACQFNTADGSRDKLGGPSVRLFNKKETPPAS--LLETICAIYRHRCS-EGSSKMYR-LRCDFLS--GKCDS- A_0520_220 -MKLTCVVIVSVLLLTACQFNTADGSRDKLGGPSVRLFNKKETPPAS--LLETICAIYRHKCS-EGSSKMYR-LRCYFLS--GKCDS- A_1387_120 -MKLTCVVIVSVLLLTACQFNTADGSRDKLGGPSVRLFNKKETPPAS--LLENICAIYRHKCS-EGSSKVYC-LRCDFLS--GKCDS- A_0239_234 --------------------------------------------PLD--RLETICAIYRHKCS-EGSSKMYR-LRCDFLS--GKCDS- victoriaeP06347 -MKLTCVVIVAVLFLTACQFNAADDSRDKQENRLARLLHKKLNSADSG-LLTKRCMEPDRRCS-EWSPERCC-TKCDYYR--SICV-- bullatusP0CY62 -MKLMCVLIVSVLVLTACQLSTADDTRDKQKDRLVRLFRKKRDSSDSG-LLPRTCVMFGSMCD-KEEHSICC-YECDYKK--GICV-- magusDAC80589 -MKLTCVLIVAVLFLTACQPSTTDDSRDKQEDRLVRLFRKKRDSSDSG-LAPKKCVLFGSICD-EESSSICC-YRCDYSQ--SICVS- arenatusQ9BP83 -MKLTCVLIVALLFLTACQLTTADDSRDKQEDPLVRSHRKMQKSEDP--KMAERCSNFGSDCI-PATHDCCS-GECFGFEDMGLCT-- imperialisAGG19135 -MKLTCMVIVAVLLLTACQLNTADGSRDKQEDRLVKLFNKRWNSPDS--RLTRKCQPNGYYCD-FEFTPKCC-LKCDYNR--KYCQPY ermineusAXL95363 -MKLTCVVIVAVLFLTACQLNTAYDSRDKLGGRLMRFFNKKRNSPVSMARVESTCILFGSICGDEDMEIECC-YRCESST--QMCKS- [Superfamily O1-5] [Framework I] [ /------Signal--------/-----------Pro-------------//CC-----C---C] V_CG13_094 -MKPTCMIIAVLFLMACQLITADYPRASDLENVAANRKAYDPIYRAIMLR CCEYD-NCPALCK V_1258_137 -MKPTCMIIAVLFLMACQLITADYPRASDLENVAANRKAYDPIYRAIMLR CCEYD-NCPALCK V_1302_210 --KPTCMIIAVLFLMACQLITADYPRASDLENVAANRKAYDPIYRAIMLR CCEYD-NCPALCK A_0875_020 -MKPTCMIIAVLFLMACQLITADYPRASDLENVAANRKAYDPIYRAIMLR CCEYG-NCAALCK A_0055_140 -MKPTCMIIAVLFLMACQLITADYPRASDLENVAANRKAYGPIYRAIMLR CCRRG-NCDSFCK A_0039_140 -MKLTCMIIAVLFLMACQLITADYPRASDLENVAANRKAYGPIYRAIMLR CCRRG-NCDSFCK V_1278_092 -----------------QLITADYPRASDLKNVAANRKASDPIYRAIMLR CCDLD-ICFALCK A_0855_120 --------------------------ASDLENVAANRKAYDPIYRAIMLR CCRRG-NCDSFCK A_0239_141 -MKPTCMIIAVLFLMACQLITADYPRASDLENVAANRKAYDPIYRAIMLR CCERD-ICLALCK A_0031_213 -MKPTCMIIAVLFLMACQLITADYPRASDLENVAANRKAYDPIYRAIMLR CCERD-ICLALCK A_0048_139 -MKPTCMIIAVLFLMACQLITADYPRASDLENVAANRKAYGPIYRAIMLR CCRRG-NCDSFCK A_0025_366 -MKPTCMIIAVLFLMACQLITADYPRASDLENVAANRKAYGPIYRAIMLR CCRRG-NCNTFCK A_0520_249 -MKPTCMIIAVLFLMACQLITADYPRASDLENVAANRKAYGPIYRAIMLR CCWRG-SCDLFCK ermineusAXL95378 -MKPTCMIIAMLFLMACQFVTADYLRASDLENVAASLKASDPIYRAIMLR CCFTDLNCPALCK [Superfamily O1-6] [Framework VI/VII] [ /-------Signal---------/----Pro-----/ /------------C------C-------CC--C----------C-/] A_0039_333 -------------------------------KNLAMK LRKNVKNSKLTKSCKPNGETCRG-MSNNCCNACMIREHPNKPVCSDK A_0055_146 --------------FLTACQLITADFFGNKEKNLAMK LRKNVKNSKLTKSCKPNGETCRG-MSNNCCNACMIRKPPNKPLCSDK A_0855_038 --------------FLTACQLITADFFGNKEKNLAMK LRKNVKNSKLTKRCKPNGETCRR-TSNDCCNACMLREPPNKPVCSDK A_1387_115 --MKLKCVVIIAVLFLTACQLITADFFGNKEKNLAMK LRKNAKNSKLTKSCKPPGKTCKG-KVSNCCKACMIRKPPNKPVCNDK A_1387_117 -MMKLTCVLIIAVLFLTACQLITADFFGNKEKNLAMK LRKNAKNSKLTKSCKPPGKTCKG-KVSNCCKACMIRKPPNKPVCNDK V_1258_161 -----------------ACQLITADFFGNKEKNLAMK LRKNVKNSKLTKSCKPPGEGCKR-TNNNCCDACKLQ-LGKAGVCSTE A_0025_227 --MKLKCVVIVALLFLTACQLITAFLYGNEEKNLAMK LRKNVKNSKLTKRCKPVGEPCEGIMSHKCCNSCMLRPFPTTPVCAH- ermineusAXL95510 --M-----------FLTACQLATTDFFGNKEKNLAMT LRKNVKKS----NCKAPDEECRG-KSHNCCGVCMIRKLPKKPICTP- [Superfamily O1-7a] [Framework VI/VII] [ /------Signal---------/-----Pro------/ /----------C------C----CC----C---------C--] magusQFQ61067 -MKLTCVLIIAVLFLMDNQLITADYPRDEQVYRAVRLR DAMQKSKGSGSCAYISEPCDILPCCPGLKC-NEDF-VPICL-- litteratusQ2I2R4 -MKLTCVLIIAVLFLMDNQLITADYPRDEQVYRAVRLR DAMQKSKGSGSCAYISEPCDILPCCPGLKC-NEDF-VPICL-- eburneusAGG19133 -MKLTCMVIIAVLFLMANQLITADYSRDEQVYRAVRLR DAMQKSKGSGSCADLSEACDILLCCPGLKC-NEDF-IPICL-- arenatusQ9BP87 -MKLTCVLIIAVLFLTACQLITADYSRDKQEYRAVRLR DAMRYSRVRRQCADLGEECHTRFCCPGLRC--EDLQVPTCLMA flavidusAFU50768 -MKLMCVLIIAVLFLTASQLITADYSRDKQEYRAERLR DAMGKFKGSRSCGHSGAGCYTRPCCPGLHC-SGGQAGGLCV-- lividusQ3YEG6 -MKLTCVLIIAVLFLTASQLITADYSRDKQEYGAERLR DAMGKFKGSRSCGHSGAGCYTRPCCPGLHC-SGGHAGGLCV-- virgoQ5K0C5 -MKLTCVLIITVLFLTASQLITADYSRDQRQYRAVRLG DEMRNFKGARDCGGQGEGCYTQPCCPGLRCRGGGTGGGACQL- leopardusAIC77160 -MKLTCMVIIAVLFLTANQHITADHSRDNLLYRAVRLR DGMRNFRGFRSCSEQGEGCATRPCCPGLNC-VGGIAGGLCQD- [Superfamily O1-7b] [Framework XI] [ /------Signal---------/------------Pro-----------/ /C------C-----CC----CC------C------C] A_0855_050 -MKLTCM-IIAVLFLMACQLITADYPRDKQKNHAVRLRDMIRNSRSREHR SCRNDGESCPSNMRCCPGLKCCGFKGGSCMAKSPGC A_0025_367 -MKLTCM-IIAVLFLMACQLITADYPRDKQENHAVRLRDMIRNSRSREHR SCRNDGESCPSHMRCCPGLKCCGFKGGACMPRNPGC V_CG13_093 -MKLTCM-IIAVLFLMACQLITADYPRDKQENHALRLRDMIRNSRSREHR SCRNDGESCPSNIRCCPGLKCCGFKGGVCMPRNPGC V_1302_108 -MKLTCM-IIAVLFLMACQLITADYPRDKQENHALRLRDMIRNSRSREHR SCRNDRESCPSNMRCCPGLKCCGFKGGACMPRNPGC A_0055_138 -MKLTCM-IIAVLFLMACQLITADYPRDKQENHAVRLRDMIRNSRSREHR SCRNDGESCPSHMRCCPGLKCCGFKGGACMPSNPGC A_0039_141 -MKLTCM-IIAVLFLMACQLITADYPRDKQENHAVRLRDMIRNSRSREHR SCRNDGESCPSHMRCCPGLKCCGFKGGACMPSNPGC [Superfamily O1-8] [Framework VI/VII] [ /--------Signal--------/---------------Pro--------------//C------C-------CC---C----------C----------] V_CG13_096 ----TCVLIAAVLLLTACQMITALE---EVREYPVQRSADEMGNSEIKPLINI-RH CDAPGSFCS-----DHCCSQKCNLLD----FECE---------- V_CG13_100 ----TCVLIAAVLLLTACQMITALE---EVQEYPVQRSADEMGNSEIKPLINI-RH CDAPGSFCS-----DHCCSQKCNLLD----FECE---------- V_CG13_097 -MKLTCVLIAAVLLLTACQMITALE---EVQEYPVQRSDDEMGNSETKPVFSLNKR CASKGSVCVGT-LHL-CC-NTCHQ------YTCT---------- V_CG13_099 -MKMTCVLIAAVLLLTACQMITALE---EVQEYPVQRSDDEMGNSETKPVFSLNKR CASKGSVCVGT-LHL-CC-NTCHQ------YTCT---------- V_CG13_098 -MKLTCVLIAAVLLLTACQMITALE---EVREYPVQRSADEMGNSEIKPLINI-RN CDAPGSYCGGTVIHRHCCSQRCVF------FKCK---------- V_1302_007 -MKLTCVLITAVLLLTACQMITALE---EVREYPVQRSADEMGNSEIKPLINI-RN CDAPGSYCGGTVIHRHCCSQRCVF------FKCK---------- A_0055_012 -MKLTCVLIAAVLLLTACQMITALE---EVQEYPVQRFADEMGNSEIKPVFSLNKR CASKGKACF-WLFKEKCC-NKCRF------NI------------ A_0039_195 -MKLTCVLIAAVLLLTACQMITALE---GVQEYPVQRSDDEMGNSETKPVFSLNKR CASKGKACF-WLFKEKCC-NKCRF------NICT---------- A_1387_041 ----------------------------EVQEYPVQRSADEMGNSEIKPVFSLNKR CASKGTSCF-WVFEVKCC-NKCRF------YVCT---------- A_0055_013 -MKLTCVLIAAVLLLTACQMITALE---EVQEYPVQRFADEMGNSEIKPVFSLNKR CASKGTVCY-WPFHT-CC-NTCRQ------NACT---------- K_0010_011 -MKLTCVLIAAVLLLTACQMITALE---EVQEFPIPRSADEMGNSEIKPLINLNKR CDPPGSYC------------------------------------ milesAKB91364 -MKLTCVLIVAVLFLTACQLITAANYARDKQEYPAVRSSDEMQDSEDLT---LTKK CTDSGQFCDPT--NHDCCSGNCIDEGGN--GVCAFVREDVPKLY betulinusAMP44715 -MKLTCVLIVAVLLLTACQLTAADN-SRGKQEHPVVRSSDEVQRSEDIK---LAKR CLGVGATCFPGTGDNLCCSQECVDFGETSTGLCS---------- [Superfamily O1-9] [Framework VI/VII] [ /-------Signal--------/------------Pro---------------/ /C------C--------CC---C----C-] V_1302_003 -MNVSSVLIVAMLTLTAGQLIRAYSHYSEEVQMAPFERSADEMENSENVQLSKR KCLEKWKFCGTLFASALCCGKLCLFHVCFL A_0055_016 -MNVSSVLIVAMLTLTAGQLIRAYSHYSEEVQMAPFERSADEMENSENVKLSKR KCLEQWKFCGSILASALCCGKLCLFNVCFI praecellensATF27691 -MKVSSVLIVAMLTLTACQLIGASSHYSQDVQMAPFVRSADEMEDSENVKLSKR KCVADWHFCGLFIFSPLCCTKLCLLTVCFA [Superfamily O2-1 (Contryphan)] [Framework XV] [ /----------Signal-------/------------Pro----------/ /C------C-----CC----C-C-----C-------C/---] A_0855_235 -------------------------------------------------PR QCTPKDHVCEDDDECCPNLECKCNTATDCQS--GYKCRG--- A_0025_277 MEKLTI--LILVATVLLAIQVLVQSDGENPLKGRVKRYAAKRLSAHMRGPR QCTPKDHVCEEEDECCPNLECKCNTATDCQS--GYKCRG--- V_CG13_058 MEKLTI--LILVATVLLAIQVLVQSDGENPLKGRVKRYAAKRLSALLRGPR QCTPKDHVCEEEEECCPNLECKCNTATDCQS--GYKCRG--- V_1302_038 MEKLTI--LILVATVLLAIQVLVQSDGENPLKGRVKRYAAKRLSAHMRGPR QCTPKDHVCEEEEECCPNLECKCNTATDCQS--GYKCRG--- V_1258_056 MEKLTI--LILVATVLLAIQVLVQSDGENPLKGRVKRYAAKRLSAHMRGPR QCTPKDHVCEEEEECCPNLECKCNTATDCQS--GYKCRG--- A_0885_130 --------LILVATVLLAIQVLVQSDGENPLKGRVKRYAAKRLSAHIRGPR QCTPKDHVCEEEDECCPNLECKCNTATDCQS--GYKCRG--- A_0875_100 MEKLTI--LILVATVLLAIQVLVQSDGENPLKGRVKQYATKRLSAHIRGPR QCTPKDHVCDEDDECCPNLECKCNTATDCQS--GYKCRG--- A_0855_244 MEKLTI--LILVATVLLAIQVLVQSDGENPLKGRVKRYAAKRLSAHMRG-- ------------------------------------------ A_0055_348 MEKLTI--LILVATVLLAIQVLVQSDGENTLKGRVKRYAAKRLSAHMRG-- ------------------------------------------ A_0055_067 MEKLTI--LILVATVLLAIQVLVQSDGENPLKGRVKQYATKRLSAHMRGPR QCTPRDHVCEEDDECCPNLECKCNTATDCQS--GYKCRG--- A_0039_034 MEKLTI--LILVATVLLAIQVLVQSDGENPLKGRVKQYATKRLSAHMRGPR QCTPRDHVCEEDDECCPNLECKCNTATDCQS--GYKCRG--- A_0048_272 MEKLTI--LILVATVLLAIQVLVQSDGENPLKGRVKRYAAKRLSAHMRGPR QCTPKDHVCEEDDECCPNLECKCNTATDCQS--GYKCRG--- A_1387_087 MEKLTI--LILVATVLLAIQVLVQSDGENPLKGRVKQYATKRLSAHMRGPR QCTPRDHVCEEDDECCPNLECKCNTATDCQS--GYKCRG--- A_0025_277 MEKLTI--LILVATVLLAIQVLVQSDGENPLKGRVKRYAAKRLSAHMRGPR QCTPKDHVCEEEDECCPNLECKCNTATDCQS--GYKCRG--- A_0239_054 MEKLTI--LILVATVLLAIQVLVQSDGGNPLKGRVKRYAAKRLSAHMRGPR QCTPKDHVCEEDDECCPNLECKCNTATDCQS--GYKCRD--- A_0239_055 -----------------------------PLKGRVKQYATKRLSAHMRGPR QCTPKDHVCEEDDECCPNLECKCNTATDCQS--GYKCRD--- A_0031_174 MEKLTI--LILVATVLLAIQVLVQSDGGNPLKGRVKQYATKRLSAHMRGPR QCTPKDHVCEEDDECCPNLECKCNTATDCQS--GYKCRD--- betulinusAMP44728 MEKLTI--LVLVATVLLAIQVLVQSDGEKPLKGRVKQYAAKRLSALMTGPR QCTPKNQICEEDGECCPNLECKCFTRPDCQS--GYKCRP--- variusAGK23205 MEKLTI--LVLVATVLLAIQVLVQSDREKPLKGRVKQYAAKRLSALMRGPR QCTPKNQICEEDGECCPNLECKCFTRPDCQS--GYKCRP--- striatusAGK23207 MEKLTI--LVLVATVLLAIQVLVQSDREKPLKGRVKQYAAKRLPALMRGPR QCTPKNQICEEDGECCPNLECKCFTRPDCQP--GYKCRP--- caracterACV07673 MEKLTI--LILVATVLLAIQVLVQSDREKPLKGRVKQYAAKRLSALLRGPR ECTPMHRACEEDEECCPNLECKCSSNPDCQS--GYKCRP--- rattusAGK23201 MEKLTV--LILVATVLLAIQVLVQSDREKPLKGGVKQYAAKRLSALLRGPR ECTPMHRACEEDEECCPNLECKCSNNPDCQS--GYKCRP--- planorbisAGK23203 MEKLTV--LILVATVLLTIQVLAQSDRDKHLKRRPKQYATKRLSALMRGTR DCTPQNVRCEEKSECCPNLECKCTSAPDCNF---YKCRT--- capitaneusC8CK78 MEKLTF--LILVATVLLTIHVLVQSDGDKHLKRRPKQYATKRLSALMRGHR QCTPQNVKCEEDDECCSNLECKCSTVPDCNF---PKCRP--- ermineusAXL95478 MEKLTI--LILVAAVLSAIQVLVQSDGEKPLKGRVKQYAAKRLSALVRGPR HCTPQNQACDEDGECCPNLECKCFTAPDCNF--GYKCGP--- V_1258_010 MKNLTI--LILVSTALLSIHVMVGGDGEKPLMG---RNAANDILALLRGKR -CKADGSTCNQDSECCSN-ECHCKNPAACSG-FTPKCQ---- V_1302_048 MKNLTI--LILVSTALLSIHVMVGGDGEKPLMG---RNAANDILALLRGKR -CKADGSTCNQDSECCSN-ECHCKNPAACSG-FTPKCQ---- V_CG13_003 MKNLTI--LILVSTALLSIHVMVGGDGEKPLMG---RNAANDILALLRGKR -CKADGSTCNQDSECCSN-ECHCKNPAACSG-FTPKCQ---- A_0055_154 MKKLTI--LILVATALLSIQVMVGGDGEKPLMG---RNAADGIWALMRGKR -CKAAGSSCELDSECCSN-ECHCKNPAGCSG-FTPKCE---- A_0239_166 MKKLTI--LILVATALLSIQVMVGGDGEKPLMG---RNAADGIWALMRGKR -CKAAGSSCELDSECCSN-ECHCKNPAGCSG-FTPKCE---- A_1387_029 MKKLTI--LILVATALLSIQVMVGGDGEKPLMG---RSAADGIWALMRGKR -CKAAGSSCQLDSECCSN-ECHCKHPAGCSG-FTPKCE---- A_0031_087 MEKLTI--LILVATALLSIQVMVGGDGEKPLMG---RNATNRVWAPITGKR -CKAAGSSCELDSECCST-ECHCKNPAGCSG-FTSKCE---- K_0010_004 MKKLTI--LILVATALLSIQVTVGGDGEKPLMGRIKRNAANGLSSLLRGKR -CK--------------------------------------- distansAGG19146 MEKLTI--LILVATALLSIQVMVRGDGEKPLMGRIKRNAAAGLSALIRGKR -CKGASALCEEDGECCSG-DCKCMHASGCTNDINLRCAA--- betulinusAMP44731 MKTLTI--LILVATALLSTHVMVGGEGEKPLMG---RNAANRLLASMRGKR -CKTRDYLCQRDEECCSGLDCRCTVHSNCSP-PHIQCK---- A_0039_186 MKKLTI--LTLVAIALVSTQVMAGCDEKKRLTG---KNAGSRLSTLMRGKR -CKTDGYLCEVDDDCCSGLDCICTVNASCTA-SNIKCKPCSG V_CG13_176 MKKLTI--LTLVAIALVSTQVMAACDEKKRLTG---KNAGSRLSTLMRGKR -CKTENYLCQRDEECCSDLDCVCTVPASCSS-SQIKCKPWTG V_1302_080 MKKLTI--LTLVAIALVSTQVMAACDEKKRLTG---KNAGSRLSTLMRGKR -CKTENYLCQRDEECCSDLDCVCTVPASCSS-SQIKCKPWTG A_0520_216 MKKLTI--LTLVAIALVSTQVMAGCDEKKRLTG---KNAGSRLSTLMRGKR -CKTKHYLCQTDDDCCSGLDCRCTVNSNCSP-SNIKCEPCLG A_0048_268 MKKLTI--LTLVAIALVSTQVMAGCDEKKRLTG---KNAGSRLSTLMRGKR -CKTKHYLCQTDDDCCSGLDCRCTVNSNCSP-SYIKCEPCLG A_0239_165 MKKLTI--LTLVAIALVSTQVMAACNGKKRLTG---KNAGSRLSTLMRGKR -CKTEDYLCQTDDDCCSDLNCRCTVNSNCSP-SNIKCKPCSG A_0031_234 MKKLTI--LTLVAIALVSTQVMAGCDEKKRLTG---KNAGSRLSTLMRGKR -CKTEDYLCQTDDDCCSDLNCRCTVNSNCSP-SNIKCKPCSG A_0025_005 MKKLTI--LTLVAIALVSTQVMAACSGKKRLTG---KNAGSRLSTLMRGKR -CKTDGYLCEVDDDCCSGLDCICTVNSSCTA-SNIKCKPCTG [Superfamily O2-2 (Contryphan)] [Framework VI/VII] [ /-------Signal------/------------Pro-----------/ /-----C------C-----CC-----C------C-----] A_0055_180 MEKLTI--LLLVAAVLMSSQALIQSGGEKRSKEKIKFLSKR-KTTAER WW-EGECRGWSNGCTRHSDCCSN--NCEGIY--C--QLW- A_0039_064 MEKLTI--LLLVAAVLMSTQALIQSGGEKRSKEKIKFLSKR-KTTAER WW-EGECRGWSNGCTRHSDCCSN--NCEGIY--C--QLW- A_0239_371 MEKLTI--LLLVAAVLMSSQALIQSGGEKRSKEKIKFLSKR-KTTAER WW-EGECRGWSNGCTRHSDCCSN--NCEGIY--C--QLW- A_0031_410 MEKLTIHTLLLVAAVLMSTQALIQSGGEKRSKEKIKFLSKR-KTTAER WW-EGECRGWSNGCTRHSDCCSN--NCEGIY--C--QLW- A_0520_217 --------------------------------------------TAER WW-EGECRGWSNGCTRHSHCCSN--NCEGIS--C--ALW- A_0875_107 MEKLTI--LLLVAAVLMSTQALIQSGGEKRPKEKIKFLSKR-KTTAER WW-EGECRGWSNSCTRHSDCCSN--NCEGIY--C--ALW- A_0885_134 M-KLTV--LFLVAVVLMSTQALIQSGGEKRSKEKIKFLSKR-KTTAER WW-EDECRGWSNGCTKHSDCCSN--NCEGIY--C--ALW- A_0855_078 MEKLTI--LLLVAAVLMSTQALIQSGGEKRPKEKIKFLSKR-KSTAER WW-EGECRGWSNGCSRHSECCSD--NCKGIY--C--ALW- A_0520_196 ---LTI--LLLVAAVLMSTQALIQSRGEKRSKEKIKFLSKR-KTTAER WW-EGECRGWSNGCTRHSDCCSY--NCEGIY--C--ALW- A_0048_164 MEKLTI--LLLVAAVLMSTQALIQXXXEKRSKEKIKFLSKR-KTTAER WW-EGECRGWSNGCTRHSHCCSN--NCEGIS--C--ALW- A_0025_338 MEKLTI--LLLVAAVLMSTQALIQSGGEKRSKEKIKFLSKR-KTTAER WW-EGECRGWSNGCTRHSECCSN--NCEGIY--C--ALW- V_1278_049 MEKLII--LLLVAAVLMSTQALIQGGGGKRPKEKMKFLSKR-KTTAER WW-EGECLGWSNGCTNPSDCCSN--NCRGTY--C--AP-- V_CG13_177 -------------------------GGGKRPKEKIKFLSKR-KTTAER WW-EGECLGWSNGCTNPSDCCSN--NCKGIY--C--AL-- A_0031_409 MEKLTI--LLLVAAVLMSTQALIQSGGEKRSKEKIKFLSKR-KTTAER WL-EGECRGWANGCTRHSDCCSN--NC------------- A_0239_244 -------------------------------------------TTAER WW-EGECRGWSNSCTRHSDCCSY--NCEGIY--C--KLW- A_1387_318 MEKLTI--LLLVAVVLMSTQALIQSGGEKRPKEKIKFLSKR-KTTAER WL-EGECSGWSNGCTKNSECCSN--NCDGTN--C--ELW- ermineusAXL95607 ----------------MSTQALIQSGGEKRPKEKIKFLSKR-KTTAER WL-EGECSGWSNGCTKNSECCSN--NCDGTN--C--ELW- ermineusAXL95607 ----------------MSTQALIQSGGEKRPKEKIKFLSKR-KTTAER WL-EGECSGWSNGCTKNSECCSN--NCDGTN--C--ELW- ermineusAXL95612 ------------------AQALTQGGGEKHPKX-DQTLSKR-NTAAER WW-EGESRGWSNGCTWRWVCCSN--TCD-TS--------- ventricosusQ9BPC7 MQKLTI--LLLVAAVLMSTQALIKGGGEKRPKEKIRFLSKR-KTTAER WW-EGECRGWSNGCTTNSDCCSN--NCDGTF--C--KLW- victoriaeG1AS80 MEKLTI--LLLVAAVLMSTQAMFQGGGEKRPKDKIKFLSKR-KTNAES WW-EGECLGWSNGCTQPSDCCSN--NCKGRN--C--DIW- andremeneziATF27464 MEKLTI--LLLLAAVLMSTQALIQGGGEKRPMEKIRFFSKR-KSNAEM WW-DGECLGWSNYCRGAYDCCSR--NCK-TY--C--QLW- praecellensATF27713 MEKLTI--LLLLAAVLMSTQALIQGGGEKRPMEKIKFFSKR-KSNFMM WW-DGECLGWSNYCRGAYDCCSR--NCK-TY--C--QLW- betulinusAMP44735 MEKLTI--LLLVAAVLISTQALILRGGEKRPKEKIKFLSKR-KPVAES WW-EGECRGWSNGCTWPSDCCSN--NCEGIY--C--GV-- marmoreusBAO02109 MQKLTI--LLLVAAVLMSTQALVQGDGKQRQKAKINFLSKR-KTTAES WW-EGECLGWSNGCTHPSDCCSN--YCKGIY--C--DL-- magusQFQ61083 MEKLTI--LLLVAALLMSTQGLIQSGGENRPKEKIKFLSKR-KSVAES WW-EGECLGWSNYCTSHSICCSG--ECILSY--C--DIW- A_0025_325 MEKLTI--LLLLAAVLMSTHVLIQGGGGKRPKENIRFLSKREKSTFEK WR-DGDCTGWLGGCSSPAECCSG--ICE-PY--C--AAW- A_0039_106 MEKLT--ILLLLAAVLMSTHVLIQGGGGKRPKENIRFLSKREKSTFEK WR-DGDCTGWLRGCSSPAECCSG--NCE-PY--C--TAW- V_1258_057 ------------------------GGGEKRPKEKIKFLSKR-KTAADR GM-WGECDDWLATCLSPSECCSE--NCD-KY--C--RAW- K_0010_341 MQKLTI--LLLVAAVMMSTQALIQGGGENRPKEIIKFLSKR-KTAADR GM-WGECDDWLTTCLSPSECCSE--NCD-KY--C--RAW- K_0010_342 MQKLTI--LLLVAAVLMSTQALIQGGGENRPKEIIKFLSKR-KTAADR GM-WGECDDWLTTCLSPSECCSE--NCD-KY--C--RAW- A_0025_322 ---------------LMSTQALIQSGGEKRPKEKIKFLSKR-KRTAER GV-WGECTDWLAHCSSPSECCSG--ICD-TY--C--RAWE ermineusAXL95356 MKKLTI--LLLVAAVLMSTQALIPSGGENRPKVNIKFLSKR-KRTAER GV-WGECTDWLAHCSSPSECCSG--ICD-TY--C--RAWE textileAAZ83753 MEKLTI--LLLVAAVLMSTQALVERAGENHSKENIKFLLKR-KRAADR GM-WGECKDGLTTCLAPSECCSE--DCE-GS--C--TMW- magusQFQ61079 MEKLTI--LLLVAAVLMSTQALVERAGENRSKENIKFLLKR-KRAADR GM-WGDCKDGLTTCFAPSECCSE--DCE-GS--C--TMW- episcopatusBAS22687 MEKLTI--LLLVAVALMSTQALSQGGGENRAKENIKFLLKR-KRAADR GM-WGDCKDGLTTCFAPSECCSE--GCD-GS--C--AMWG geographusBAO65631 MEKLTI--LLLVAAVLMSTQAMIQGGGENRPKKNIKYLSKS-QRSAES GI-WGECSDFLTGCTSPSQCCSE--NCD-TY--C--RAW- A_1387_243 MEKLTI--LLLVAAVLMSTQALIKGGGEKRPKEKIKFLSKR-KRDA-- ---------------------------------------- A_0055_369 -----------------------------RPKEKIKFLSKR-KRDAER WW-EGECTDWLGTCTSPAQCCTG--VCD-AY--C--AAW- A_0048_270 MEKLTI--LLLVAAVLMSTQALIKGGGEKRPKEKIKFLSKR-KRDAER WW-EGECTDWLATCTSPAQCCTG--VCD-RY--C--AAW- A_0520_213 MEKLTI--LLLVAAVLMSTQALIQSGGEKRPKEKIKFLSKR-KRDAER WW-EGECTDWLATCTSPAQCCTG--VCD-RY--C--AAW- A_0239_372 --KLTI--LLLVAAVLMSTQALIQSGGEKRPKEKIKFLSKR-KRDAER WW-EGECTDWLASCTSPAQCCTG--VCD-RY--C--AAW- A_0031_287 M-KLTI--LLLVAAVLMSTQALIQSGGEKRPKEKIKFLSKR-KRDAER WW-EGECTDWLASCTSPAQCCTG--VCD-RY--C--AAW- A_0031_290 MQKLTI--LLLVAAVLMSTQALIQSGGEKRPKEKIKFLSKR-KRDAER WW-EGECTDWLASCTSPAQCCTG--VCD-RY--C--AAW- A_0025_321 MEKLTI--LLLVAAVLMSTQALIQSGGEKRPKEKIKFLSKR-KRDAER WW-EGECTDWLASCTSPAQCCTG--VCD-RY--C--AAW- A_0048_271 MEKLTI--LLLVAAVLMSTQALIKGGGEKRPKEKTKFLLKR-KRDAER WW-EGECTDWLGTCISPAQCCTG--VCD-RY--C--AAW- A_1387_316 MEKLTI--LLLVAVVLMSTQALIKGGGEKRPKEKIKFLSKR-KRDAER WW-EGECTDWLGSCISPAQCCTG--VCD-GY--C--AAW- V_1302_083 MQKLT--ILLLVAAVLMSTQALIKGGGEKRPKEKIKFLSKR-KRDAEK WW-EGECRDWLGSCTSPAQCCSE--VCD-GY--C--AAW- V_CG13_180 MEKLT--ILLLVAAVLMSTQALIKGGGGKRPKEKIKFLSKR-KRDAEK WW-EGECRDWLGSCTSPAQCCSE--VCD-GY--C--AAW- A_0855_082 MEKLT--ILLLVAAVLMSTQALIQSGGEKRPKEKIKFLSKR-KRDAER WW-EGECTDWLGTCTSPAQCCTG--VCD-AY--C--AAW- A_0039_107 --KLT--ILLLVAAVLMSTQALIQGGGEKRPKEKIKFLSKR-KRDAER WW-EGECTDWLGTCTSPAQCCTG--VCD-AY--C--AAW- V_CG13_181 ----------------MSTQALIKGGGGKRPKEKIKFLSKR-K-TAES WW-GAECTDWLVGCTSPAQCCSG--VCE-GF--C--AAW- V_1278_055 ----------------MSTQALIKGGGEKRPKEKIKFLSKR-K-TAES WW-GAECTDWLVGCTSPAECCSG--VCE-GF--C--AAC- V_CG13_183 MEKLT--ILLLLAAVLMSPQVLIQGGGGKRPKEQIKLLSKR-KPDAER -R-GGDCKGLLRGCSAPAECCSG--RCQ------------ V_1302_068 MEKLT--ILLLLAAVLMSTQVLIQGGGGKRPKEQIKLLSKR-KPDAER -R-GGDCKDWLGGCSAPAECCSG--LCQ-GH--C--ALWS V_1258_066 ---------LLLAAVLMSTQVLIQGGGGKRPKEQIKLLSKR-KPDAER -R-GGDCKDWLGGCSAPAECCSG--LCQ-GH--C--ALWS A_0055_359 ----------------------------KRPKENIRFLSKR-KSTFEK WR.EGECMGWLLGCSSPAECCSG--PCQ-GH--C--AGWS ermineusAXL95358 MEKLTI--LLLVAAVLMSTQALIQGGGEKRPKEKIKFLSKR-MSTAAR WW-EGECFATLRTCLSPSDCCSG--NCYHTH--C--AAW- imperialisAME17677 MEKLTI--LLLVTAVLMSTQALMQSGIEKRQRAKIKFFSKR-KTTAER WW-EGECYDWLRQCSSPAQCCSG--NCG-AH--C--KAW- magusQFQ61082 MEKLTI--LLLVTAVLMSTQALMQSGIEKRQRAKIKFFSKR-KTTAER WW-EGECYDWLRQCSSPAQCCSG--NCG-AH--C--KAW- V_CG13_151 ------------------------------------------------ -W-ENECSGWSVYCTQHSECCSG--ECTGNY--C--GL-- A_0885_128 MEKLTI--LLLVAAVLMSTQALIQDGGEKHQK-----------SSAQS WW-EGECSGWSVYCTQHTECCSH--SCERAY--C--TLW- A_0039_062 ------------------------DGGEKHQKAKINFLSKR-KSSAQS WW-EGECSGWSVYCTQHTECCSH--SCERAY--C--TLW- A_0055_176 MEKLTI--LLLVAAVLILTQALIQDGGEKHQKAKINFLSKR-KSSAQS WW-EGECSGWSVYCTQHTECCSH--SCERAY--C--TLW- A_0875_108 MEKLTI--LLLVAAVLMSTQALIQDGGEKHQKAKINFLSKR-KSSAQS WW-EGECSGWSVYCTQHTECCSH--SCERAY--C--TLW- V_CG13_178 MEKLTI--LLLVAAVLMSTQALIQDGGEKHQKA-INFLSKR-KSSAES WW-EGECSGWSVYCTQHTECCSH--SCEREY--C--TLW- V_1278_053 MEKLTI--LLLVAAVLMSTQSLSQDGGKKHQKAKINFLSKR-ESTAES WW-EGECSGWSVHCTQHTECCSH--SCEYEY--C--TLR- A_0875_105 ----------------------------KRLKEKIK-LSSR-KSTFER WW-NNECSDWSDYCTADHQCCSD--DCDGNY--C--LLFG A_0885_129 ----------------------------KRLKEKIK-LSSR-KSTFER WW-NNECSDWSDYCTADHQCCSD--DCDGNY--C--LLFG A_1387_317 MEKLTI--LLLVAAVLMSTQALIQDGGEKHQKAKINFLSKR-KSSAQS WW-EGECSGWSVYCTQHTECCSH--SCERAY--C--TLW- A_0239_375 MEKLTI--LLLVAAVLMSTQALIQDGGEKHQKAKINFLSKR-KSSAQS WW-EGECSGWSVYCTQHTECCSH--SCERAY--C--TLW- A_0031_229 MEKLTI--LLLVAAVLMSTQALIQDGGEKHQKAKINFLSKR-KSSAQS WW-EGECSGWSVYCTQHTECCSH--SCERAY--C--TLW- A_0025_328 MEKLTI--LLLVAAVLMSTQALIQDGGEKHQKAKINFLSKR-KSSAQS WW-EGECSGWSVYCTQHTECCSH--SCERAY--C--TLW- A_1387_320 MEKLTI--LLLVAVVLMSTQALIQDGGEKHQKAKINFLSKR-KSSAQS WW-EGECSGWSVYCTQHTECCSH--SCERAY--C------ A_0520_195 MEKLTI--LLLVAAVLMSTQALIQDGGVKHQKAKINFLSKR-KSSAQS WW-EGECSGWSVYCTQHTECCSH--SCEHAY--C--TLW- ventricosusAAG60434 MQKLTI--LLLVAAVLMSTQALIKGGGEKRPKEKIKFLSKR-KTTAES WW-EGECSGWSVYCTQHSECCSG--ECTGNY--C--ELF- betulinusQ3YEF9 MEKLTI--LLLVAAVLMSTQALIQSDGEKRQQAKINFLSXR-KSTAES WW-EGECKGWSVYCSWDWECCSG--ECTRYY--C--ELW- A_0039_337 ---------------------------------------KR-KRTDES WL-DDECRTWFAPCDFSSQCCSE--VCNIRNGLC--LE-- A_0055_370 MEKLTI--LLLVAAVLMSTQALIKGGGEERQKAKINFFFKR-KRTDES WL-DDECRTWFAPCDFSSQCCSE--VCNIRNGLC--LE-- V_CG13_353 -----------------------------RQKAKINFLSKR-ESTFVK WW-IGKCGTWSVHCFSPTRCCSK--ACSTRTNTC--ML-- V_1278_188 MEKLTI--LLLVAAVLMSTQSLSQDGGKKHQKAKINFLSKR-ESTFVK WW-IGKCGTWSVHCYSPARCCSK--SCSTKTNSC--M--- V_1278_189 MEKLTI--LLLVAAVLMSTQSLSQDGGKKHQKAKINFLSKR-ESTFVK WW-KGKCRTWHVHCYTPPQCCSK--SCSAKTNSC--ML-- A_0855_075 ------------------------------------FFSKR-KTTAES WW-EGECRTWYAPCNFPSQCCSE--VCSSKTHRC--LAW- A_0885_118 ------------------------------------FFSKR-KTTAES WW-EGECRTWNAPCNFPSQCCSE--VCSSKTRRC--LAW- V_CG13_182 ------------------------------------FFSKR-KTTAES WW-EGECRTWYAPCHFPSQCCSE--VCSVRNNRC--LAW- V_1302_085 ------------------------------------FFSKR-KTTAES WW-EGECRTWYAPCHFPSQCCSE--VCSVRNNRC--LAW- V_1278_052 ------------------------------------FFSKR-KTTAES WW-EGECRTWYAPCDFPSQCCSE--VCSIRNNRC--LAW- A_0055_178 MEKLTI--LLLVAAVLMSTQALIKGGGEERQKAKINFFSKR-KTTAES WW-EGECRTWNAPCNFPSQCCSE--VCSSKTHRC--LAW- A_0875_106 MEKLTI--LLLVAAVLMSTQALIKGGGEERQKAKINFFSKR-KTTAES WW-EGECRTWNAPCNFPSQCCSE--VCSSKTHRC--LA-- A_0039_184 MEKLTI--LLLVAAVLMSTQALIKGGGEERQKAKINFFSKR-KTTAES WW-EGECRTWNAPCNFPSQCCSE--VCSSKTHRC--LAW- A_1387_240 MEKLTI--LLLVAAVLMSTQALIKGGGEERQKAKINFFSKR-KTTAES WW-EGECRTWKAPCNFPSQCCSK--VCSSKTRRC--LAW- A_1387_242 -----------------STQALIQGGIEKHQKAKINYVSKR-KTTAES WW-EGECRTWKAPCNFPSQCCSK--VCSSKTRRC--LAW- A_0520_215 MEKLTI--LLLVAAVLMSTQALIKGGGEERQKAKINFFSKR-KTTAES WW-EGECRTWLAPCNFPSQCCSE--VCSSKTHNC--LAW- A_0048_269 MEKLTI--LLLVAAVLMSTQALIKGGGEERQKAKINFFSKR-KTTAES WW-EGECRTWLAPCNFPSQCCSE--VCSSKTHNC--LAW- A_0025_326 MEKLTI--LLLVAAVLMSTQALIKGGGEERQKAKINFFSKR-KTTAES WW-EGECRTWLAPCNFPSQCCSE--VCSSKTHKC--LAW- A_0239_374 --KLTI--LLLVAAVLMSTQALIQGGGEERQKAKINFFSKR-KTTAES WW-EGECRTWQAPCNFPSQCCSE--VCSSKTHRC--L--- K_0010_339 MEKLTI--LLLVAAVLMSTQALIQSGGEKRQKAKVNFLSKR-KTTAER WW-EGECSGWSVYCSWDSECCSG--ECG------------ K_0010_340 MEKLTI--LLLVAAVLMSTQALIQSGGEKRQKAKVNFLSKR-KTTAES WW-EGECRTWDAPCNFPSQCCSD--ICSSKTRRC--LAW- ventricosusQ9BPC5 MQKLTI--LLLVAAVLMSTQALIRGGVEKRQEAKRNFFSKR-KTTAES WW-EGECRTWYAPCNFPSQCCSE--VCSSKTGRC--LTW- brunneusAFI41810 MEKLTI--LLLVVTVLVSTQAMIQGDMEKRRKAKINIFSKR-KTTAER WW-DGECRSWSNKCEWPWHCCSN--DCED-Y--C--TLW- magusQFQ61077 MEKLTI--LLLVAAVLMSTQALIQGDVDERQQAKIKFLSKR-KSTAES WW-EGECRTWNAPCSFTSQCCFG--RCS--HHRC--IAW- V_1258_067 ----------LVAAVLMLTQALIEDGGDKRQQEKINFFSKR-KPSAKR WWGENDCTDWLGHCLVDTECCSD--NCEGMF--C--RLW- V_CG13_184 MEKLTI--LLLVAAVLMSTQALVQ---EKRQQAKVNLFSKR-KPSAKR WWGHDECTYWLGHCMVDAECCSD--SCEKRF--C--GLW- A_0055_175 MEKLTI--LLLVAAVLMSTQALVQ---EKRQQAKVNLFSKR-KPSAKR WWGDDECTYWLGHCMVDTECCSD--SCEERF--C--GLW- A_0039_066 ----------------------VQ---EKRQQAKVNLFSKR-KPSAKR WWGDDECTYWLGHCMVDTECCSD--SCEERF--C--GLW- A_0239_164 ----TI--LLLVAAVLMSTQALVQ---EKRQQAKVNLFSKR-KPSAKR WWGHDECTYWLGHCMVDAECCSD--SCEERF--C--GLW- A_0031_233 MEKLTI--LLLVAAVLMSTQALVQ---EKRQQAKVNLFSKR-KPSAKR WWGHDECTYWLGHCMVDAECCSD--SCEERF--C--GLW- A_0520_212 MEKLTI--LLLVAAVLMSTQALVQ---EKRQQAKVNLFSKR-KPSAKR WWGDDECTYWLGHCMVDTECCSD--SCEERF--C--GLW- A_0025_323 MEKLTI--LLLVAAVLMSTQALVQ---EKRQQAKVNLFSKR-KPSAKR WWGDDECTYWLGHCMVDTECCSD--SCEERF--C--GLW- A_0048_275 MEKLTI--LLLVAAVLMSTQALVQ---EKRQQAKVNLFSKR-KPSAKR WWGDDECTYWLGHCMVDTECCSD--SCEEMF--C--GLW- K_0010_338 MQKLTI--LLLVAAVLMSTQALIQDGGEKRQQAKINFFSKR-KPSAKR WWRHDECTYWLGHCMVDAECCSD--SCEEMF--C--GLW- betulinusAMP44799 ---------LLVAAVLMSTQALIQ---EKRQQAKINLFSRR-KPSAKR WWGHDECTYWLGHCIVDSECCSD--SCEERF--C--GLW- imperialisAGG19144 MEKLTI--LLLVAAVLVSTQALIQG-GEKRQKAMINFLSKR-KPSAKR WWGDERCTYWLGPCIVDSECCSN--SCEERF--C--GLW- praecellensATF27712 MEKLTI--LLLVAAVLVSTQALIQGGGEKRQKAKINFFSKR-KPSSKR WWGHDECRYWLGPCELDSDCCSD--SCEEKF--C--GLW- andremeneziATF27469 MQKLTI--LLLVAAVLVSTQALIQGGGEKRQKAKINFFSKR-KPSSKR WWGHDECRYWLGPCELDSDCCSD--SCEEKF--C--GLW- A_0855_079 ----------LVAAVLMSTQALIQSGGEKRPKQKITSLSKR-KATAEK WW-DGECIGWGYGCAFPWECCSK--SCDR-Y--C--RMW- V_CG13_185 ----------------MSTQALIQSGGEKRPKQKFTSLSKR-KATAEK WW-DGECISWGYGCAFPWECCSK--SCDR-Y--C--RMW- A_0031_232 ----------LVAAVLMLTQALIQSGGEKRPKQKITSLSKR-KSTAEK WW-DGECIGWGYGCAFPWECCSK--SCDR-Y--C--RMW- A_0239_378 -------------------------GGEKRPKQKITSLSKR-KATAEK WW-DGECIGWGYGCAFPWECCSK--SC------------- A_0875_242 MEKLTI--LLLVAAVLILTQALIQDGGEKRQQEKINFFSKR-KPS--- ---------------------------------------- A_0055_177 MEKLTI--LLLVAAVLILTQALIQDGREKRQQEKINFFSKR-KPSAKR LWGNEKCSLWLGPCQVDAECCTG--GCEQMF--C--V--- A_0855_083 MEKLTI--LLLVAAVLILTQALIQDGGEKRQQEKINFFSKR-KPSAKR LWGNEECSLWLGPCQVDAECCTG--GCERMF--C--V--- A_0239_136 MEKLTI--LLLVAAVLILTQALIQDGREKRQQEKINFFSKR-KPSAKR LWGNEKCSLWLGPCQVDAECCTG--GCEQMF--C--V--- A_0520_208 -------------------------GGEKRQQEKINFFSKR-KPSAKR LWGNEECSLWLGPCQVDAECCAG--GCEQMF--C--V--- A_0025_330 -----------------------------------TFFSKR-KPSAKR LWGNEECSLWLGPCQVDAECCAG--GCE------------ A_0855_081 M-KLTI--LLLVAAVLMSTQALIQGDGEKRQEAKINLRTAK-NKQA-R ----TECGQFFDTCDHASECCSQ-YHCDTGY--CIGSYWN A_0885_114 MEKLTI--LLLVAAVLMSTQALIQGDGEKRQEAKINLRTAK-NKQA-R ----TECGQFFDTCDHASECCSQ-YYCDTGY--CIGSYWN A_0875_109 M-KLTI--LLLVAAVLMSTQALIQGDGEKRQEAMINLRTAK-NKQA-R ----TGCGQFLDSCDHASECCSQYYYCDTGY--CIGS--- A_0055_174 M-KLTI--LLLVAAVLMSTQALIQGDREKRQEAKINLRTAK-NKQA-R ----TGCGQFFDTCDHASECCSQ-YYCDTGY--CIGSYWN A_0039_067 MEKLTI--LLLVAAVLMSTQALIQGDGEKRQEAKINLRTAK-NKQA-R ----TECGQFFDTCDHASECCSQ-YYCDTGY--CIGSY-- A_0031_235 ---------------------------------------------A-R ----TGCGQFLDSCDHASECCSQYYYCDTGY--CIGSYWN A_1387_239 M-KLTI--LLLVAAVLMSTQALIQGDGEKRQEAKINLRTAK-NKQA-R ----TGCGQFFDSCDHASECCSQ-YYCHTGY--CIGSYWN A_0239_376 M-KLTI--LLLVAAVLMSTQALIQGDGEKRQEAKINLRTAK-NKQA-R ----TGCGHFFDSCDNASECCSQ-YYCHTGY--CIGSYWN A_0520_214 M-KLTI--LLLVAAVLMSTQALIQGDGEKRQEAKINLRTAK-NKQA-R ----TGCGQFLDSCDHASECCSQYYYCHTGY--CIGSYWN A_0048_273 M-KLTI--LLLVAAVLMSTQALIQGDGEKRQEAKINLRTAK-NKQA-R ----TGCGKLLDSCDYASECCSR-YYCDTGY--CIYSNWN A_0025_324 MEKLTI--LLLVAAVLMSTQALIQGDGEKRQEAKINLRTAK-NKQA-R ----TGCGQFFDTCDHASECCSQ-YYCHTGY--CIGSYWN A_0039_108 --KLTI--LLLVAAVLMSTQALIQ---EKRLKEKIK-LSSR-KSSFQR -WLNKKCSDWSDYCTADHQCCSG--ECDGNY--C--LLYG A_0239_245 MEKLTI--LLLVAAVLMSTQALIQ---EKRLKEKIK-LSSR-KSSFQR -WLNKKCSDWSDYCTADHQCCSG--ECDGNY--C--LLYG A_0031_231 MEKLTI--LLLVAAVLMSTQALIQ---EKRLKEKIK-LSSR-KSSFQR -WLNKKCSDWSDYCTADHQCCSG--ECDGNY--C--LLYG [Superfamily O2-3 (Contryphan)] [Framework VI/VII] [ /-----Signal------/-------------Pro------------/ /-C------C------CC----C----C---] A_0875_244 ------------------------------AKINFLAAKTLLGNKKAR -ACAGLFSYCGDPSVGCCEWYVCVRHYCTV-- A_0855_076 MEKLTILLLVAVVLMSTQALIERGGENPQKAKINFLASKTLLGNKKAR -ACAGLFSYCGDPSVGCCEWYVCVRHYCTV-- A_0031_288 MEKLTILLLVAVVLMSTQALIERGGENPQKAKINFLAAKTLLGNKKAR -ACAGLFSYCGDPSVGCCEWYVCVRHYCTV-- A_0025_340 MEKLTILLLVAVVLMSTQALIERGGENPQKAKINFLAAKTLLGNKKAR -ACAGLSSYCGDPSVGCCERYVCVRHYCTV-- ermineusAXL95459 MEKLTILLLVAAVLMSTQALIERGGENPQKAKINFLAAKTLLGNKKAR -ACAGLSSYCGDPSVGCCERYVCVRHYCTV-- praecellensATF27720 MEKLTILLLVAAVLVSTQALIQGGGEKKQNAKINFFTARKLSGNKKAR -DCVGLFSYCA--STSCCPSLYCKNVYCAWG- A_1387_321 -------LLVAVVLVSTQALIQGGAENPQKAKINFYTAKKLSGNRKAR AECANWAHGC-DAKKPCCELLRCEDLYCTY-- andremeneziATF27474 MEKLTILLLVAAVLVSTQALIQGGGENPQKAKINFYTARQLSGNRQAR -ECGMWYQAC-DDTHPCCDWSRCHNNYCITAI praecellensATF27716 MEKLTILLLVAAVLVSTQALIQGGGEKPQKAKINFYTARQLSGNREAR -ECGMWYQAC-DDTHPCCDWSRCHNNYCITTI [Superfamily O2-4 (Contryphan)] [Framework VI/VII] [ /----Signal-----/---Pro---/ /----------------------C------C-----CC----C------C---------------------] V_CG13_356 MEKLTILLLVAAVQLSTQVLFQGYGER PHKAKINFYTSRMLS--------------------------------------------------------- A_0855_077 MEKLTILLLVAVVQLSTQVLVQGDGET PHKVKINFYTSRMLSGHNRQT--CIQSADPCTSDELCCSGS-CSDV---CA--------------------- A_0875_133 MEKLTILLLVAAVQLSTQVLVQGDGET PHKVKINFYTSRMLSGHNRQT--CIQSADPCTSDELCCSGS-CSDV---CA--------------------- A_0055_179 MEKLTILLLVAAVQLSTQVLVQGDGET PHKVKINFYTSRMLSGHNRQT--CIQSADPCTSDELCCSGS-CSDV---CA--------------------- A_0039_063 MEKLTILLLVAAVQLSTQVLVQGDGET PHKVKINFYTSRMLSGHNRQT--CIQSADPCTSDELCCSGS-CSDV---CA--------------------- V_1302_082 MQKLTILLLVAAVQLSTQVLFQGYGER PHKAKINFYTSRMLSGNNRQT--CIQSADPCTSDELCCSGS-CSGVWRRCDEV------------------- V_1278_054 MEKLTILLLVAAVQLSTQVLFQGYGER PHKAKINFYTSRMLSGNNRQT--CIQSADPCTSDELCCSGS-CSGVWRRCDEV------------------- V_1258_160 --------------------------- ----KINFYTSRMLSGNNRQT--CIQSADPCTSDELCCSGS-CSGVWRRCDEV------------------- A_1387_348 MEKLTILLLVAAVQLSTQVLVQGDGET PHKVKINFYTSRMLSGHNRQT--CIQSADPCTSDELCCSGS-CSDV---CA--------------------- A_0048_165 MEKLTILLLVAAVQLSTQVLVQGDGET PHKVKINFYTSRMLSGHNRQT--CIQSADPCTSDELCCSGS-CSDV---CA--------------------- A_0031_289 MEKLTILLLVAAVQLSTQVLVQGDGET PHKVKINFYTSRMLSGHNRQT--CIQSADPCTSDELCCSGS-CSDV---CA--------------------- A_0239_373 MEKLTILLLVAAVQLSTQVLVQGEGET PHKVKINFYTSRMLSGQNRQT--CIQSADPCTSDELCCSGS-CSDV---CA--------------------- A_0885_117 MEKLTILLLVAAVLLSTQVLVQGDGEK PQKEPVDVFTTRMLSGNMQKR--CLLSGQHCSYSTQCCSTY-CRRRMRKCY--------------------- A_0039_061 -------------------LVQGDGEK TQKEPIDVFTTRMLSGNKQKR--CLLSGQHCSYSTQCCSTY-CRRRMRKCY--------------------- A_0031_291 MEKLTILLLVAAVLLSTQVLVQGDGEK PQKEPIDVFTTRMLSGNKQKR--CLLSGQHCSYSTQCCSTY-CRRRMRKCY--------------------- ermineusAXL95518 ----------------TQVLVQGDGEK PQKEPVDVFTTRMLSGNMQKR--CLLSGQHCSYSTQCCSTY-CRRRMRKCY--------------------- betulinusAMP44727 MEKLTILLLLAAVLMSTQVLVQGDREK PQKAPIDFLTARMLSGNNEKR--CLASGSWCEYSTQCCSTY-CRHRVHKCA--------------------- distansAGE10527 MEKLTILLLVAAVLLSTQVLVQGDGEK SQK-RMDLLKGRMLSGNLNKR--CDTWRDPCTYEHECCWQYHCGF-RT-CE--------------------- magusDAC80592 MEKLTILLLVAAVLLSTQVLVQGDGET PHKAKINFYASRLLSGNMRSRKNCGYAFDACTSDRQCCSGY-CVGN-VYCK--------------------- praecellensATF27721 MEKLTILVLLAAVLLSTQVLVQGDGEK PQKKKRDFIKARMVSGNMQKR--CDGRDMPCAMDSECCPPYNCVN--TFCEDWLTRDLTTSHQTSPFSSSEA andremeneziATF27475 MEKLTILVLVAAVLLSTQVLVQGDGEK PQKKKRDFIKARMVSGNMQKR--CDGRDMPCAQDSECCPPYDCVN--TFCEDWLTRDLTTSHQTSPFSSSEA marmoreusAGG19147 MEKLTILRLVAAVLLSTQVLVQGDEEN PQKALIDILTGRMVSGKKPKD--CLPIGSLCHSSEQCCSGW-CSPKRV-C---------------------- [Superfamily O2-7 (Contryphan)] [New Framework] [ /-------Signal-------/ /----------------------------C------C-----CC----C-C-----C-------C--C/] A_0039_185 -MKKLTILTLVAIALVSTQVM AGCDEKKRLTGK---NAGSRLSTLMRGKR-CKTEDYLCQTDDDCCSDLECRCTVNSNCSPSNIK-CKPCSG K_0010_365 -MEKLTILILVATVLLATQVL VQSDGENPLKGRVKQYAAKRLSALLRGPRQCIPENQACEEDEECCPNLECRCFSRPDCQSGY--------- A_0855_141 -MKKLTILTLVAIALVSTQVM AGCNEKKRLTGK---NAGSRLSTLMRGKR-CKTEDYLCQEDDDCCSDLDCRCTVNANCSPSYIK-CKPCSG A_0885_135 -MKKLTILTLVAIALVSTQVM AGCNEKKRLTGK---NAGSRLSTLMRGKR-CTTEGNLCQTDDDCCSDLDCRCTVNANCSPSNIM-CKPCLG A_0875_038 -MRKLTILTLVAIALVSTQVM AGCDEKKRLTGK---NAGSRLSTLMRGKR-CTTENNLCQTDDDCCSDLDCRCTVNANCSPSNIM-CKPCLG A_0055_153 -MKKLTILTLVAIALVSTQVM AGCDEKKRLTGK---NAGSRLSTLMRGKR-CATEDNLCQTDDDCCSDLDCRCTVNANCSPSNIM-CKPCLG A_0239_168 -MEKLTILILVATALLSIQVL VGGDGEKPLMGG---NTAKRLSALMRGKS-CKTRDYLCRVDQECCPGLDCKCTVASSCTAPNIK-CK---- betulinusAMP44624 -MKKLTILILVATALLSTHVM VGGDGEKPLMGR---NAANRLLAIGIGKR-CKTEDYLCQRDEDCCSGLDCRCTVNANCSPPYIK-CKP--- distansAGG19146 -MEKLTILILVATALLSIQVM VRGDGEKPLMGRIKRNAAAGLSALIRGKR-CKGASALCEEDGECCSG-DCKCMHASGCTNDINLRCAA--- [Superfamily O2-8 (Contryphan)] [Framework VI/VII] [ /----------Signal------/-----------Pro----------/ /----C------C-------CC----C---C-------] V_1302_081 -M-KLTILFLVAAVLMSTQALIQGDGEKNQKAKMKFLTARKLSAKK--R --DVECVGWSGYCGPWNNPPCC----------------- V_1258_058 -M-KLTILFLVAAVLMSTQALIQGDGEKNQKAKMKFLTARKLSAKK--R --DVECVGWSGYCGPWNNPPCC----------------- A_0885_131 --------------------------EKKQKAKMKFLTARKLSAKK--R --KGVCLGWSGYCGPWNNPPCCSSYTCDSYCRFLGKPY- A_0048_166 -M-KLTILFLVAVVLMSTQVMIQGDGEKKQKAKMKFLTARKLSAKK-GR ---DDCVGWSGYCGRWNNPPCCSWYTCNYYCQFPGSPY- A_0239_377 -MEKLTILFLVAVVLMSTQAPIQGDGEKKQKAKMKFLTARKLSAKK--R --EGDCIGWSGDCGKWNYPACCSRYTCDSYCQFPGNPY- ventricosusQ9BPC4 -M-KLTILFLVAAVLMSTQALIQHDGEKSQKAKMKFLTARTLSAKT--R --GVDCVGLSSYCGPWNNPPCCSWYTCDYYCKF------ milesAKB91372 -MEKLTILLLVAAVLMLTQVVIQGVGEKHENTKMNFYKARKLAGNKHSR SSDEECVGLSGYCGPWNNPPCCSWWECEVYCAVPGPSFK [Superfamily O2-9] [Framework VI/VII] [ /-----Signal-----/-----------Pro-----------/ /--C------C-----CC----C---C-------------------------] V_1278_194 --------------------------------------AQVLRR VPDCKREGVGCEERTECCFGLICKDEACKHVSPGPGRALDHRAEPILQKKQQP V_1302_035 -MGELTALLFLVTVMVLTQVMVESDQDKPLNRRRYLRKAQVLRR VPDCKREGVGCEERTECCFGLICKDEACTHVSPGPGRALDHRAAPILQKKQQP V_CG13_069 -MGELTALLFLVTVMVLTQVMVESDQDKPLNRRRYLRKAQVLRR VPDCKREGVGCEERTECCFGLICKDEACTHVSPGPGRALDHRAAPILQKKQQP V_1258_157 -MGELTALLFLVTVMVLTQVMVESDQDKPLNRRRHLREAQVLRR VPDCKREGVGCEERTECCFGLICKDEACKHVSPGPGRALDYRAAPILQKKQQP A_0039_009 -MGELTALLFLVTVMVLTQVMVESDQDKPLKRRRYLRKAQVLRR VTDCKREGVGCEERTECCFGLTCKDNACKHVSTGPGRALDYREEPILQKK--P milesAKB91386 -MGILTVLLPLVAVLVLTQVIVRSDQDKPLNRRRNIREAQALRR VRDCNIQEDACESNDDCCLGLFCKNEVCEYASPG-RRAVENRAALIRENK--P [Superfamily O2-10 (Contryphan)] [Framework XV] [ /---------Signal-----/--------Pro--------//C------C-----CC----C-C-----C-------C--] A_0055_078 MMKKLAMLLLGATVLLLVPVIGRGDGGDDEGPRSIVLDLEKR CKQNGETCESDSECCEGSRCTCLQPSACSDKLSGKCRTS A_0039_135 MMKKLAMLLLGATVLLLVPVIGRGDGGDDEGPRSIVLDLEKR CKQNGETCESDSECCEGSRCTCLQPSACSDKLSGKCRTS A_1387_016 MMEKLAMLLLGATVLLLVPVIGRGDGGDDEGPRSIVLDLEKR CKENGETCESDSECCEGSRCICLQPAACSDNSSGKCRTS A_0031_450 MMKKLAMLLLGATVLLLVPVIGRGDGGDDEGPRSIVLDLEKR CKQNGETCESDSECCEGSRCTCLQPSACSDKLSGKCRTS A_0885_047 MMEKLAMLLLGATVLLLISVIVRGDRGDDQGAWSSVLDLNKR CKEEYEACKT-DECCHPLLCICRQPAACSGANNGKCTRS A_0055_076 MMEKLAMLLLGATVLLLISVIVRGDRGDDQGAWSSVLDLNKR CKEEYEACKR-DECCHPLVCTCRQPAACSGANNGKCTRS A_0055_077 MMEKLAMLLLGATVLLLISVIVRGDRGDDQGAWSSVLDLKNR CKGEYEACKR-GQCCPSLRCICRQVSACSGANQGKCTRS A_0039_133 ------MLLLGATVLLLISVIVRGDRGDDQGAWSSVLDLKNR CKEENEACKK-GECCDPLLCICRQPAACSGANNGKCRSS A_0055_074 ------MLLLGATVLLLISVIVRGDRGDDQGAWSSVLDLNKR CKGENEACER-GQCCSHLLCICRQPAACSGATKGKCKKS [Superfamily O2-WF (Contryphan)] [No Framework, short mature pep.] [ /--------Signal-------/---------Pro------------------------------/ /C-------C/---------] A_0855_105 MEKLTILFLVAAVLLSTQAMVQGDGDQPAERDAVPRERDAVPRDDNSGG----TSGKF-MNALRQS GCPWQP--WCG---------- A_0520_276 MEKLTILFLVAAVLLSTQVMVQGDGDQPAERDAVPRERDAVPRDDNSGG----TSGKF-MNALRQS GCPWKP--WCG---------- A_0885_120 MEKLTILFLVAAVLLSTQVMVQGDGDQPAERDAVPRERDAVPRDDNSGG----TSGKF-MNALRQS GCPWKP--WCG---------- A_0875_102 MEKLTILFLVAAVLLSTQVMVQGDGDQPAERDAVPRERDAVPRDDNSGG----TSGKF-MNALRQS GCPWKP--WCG---------- A_0039_102 MEKLTILFLVAAVLLSTQVMVQGDGDQPADRDAVPRERDAVPRDDNSGG----TSGKF-MNALRQS GCPWKP--WCG---------- A_0055_197 MEKLTILVLVAAVLLSTQVMVQGDGDQPAERDAVPRERDAVPRDDNSGG----TSGKF-MNALRQS GCPWKP--WCG---------- A_0048_239 MEKLTILFLVAAVLLSTQVMVQGDGDQPAERDAVPRERDAVPRDDNSGG----TSGKF-MNALRQS GCPWKP--WCG---------- V_1302_332 -------------------------DQPA-------DRNAVPRDDNPGG----ASGKL-MAILRRS VCPWHP--WCG---------- V_1302_333 -------------------------DQPA-------DRNAVPRDDNPGG----ASGKL-MAILRRS GCPWHL--WCG---------- V_1302_334 -------------------------DQPA-------DRNAVPRDDNPGG----ASGKL-MAILRRS GCPWHP--WCG---------- A_0055_375 -------------------------DQPA-------DRNAVPRDDNPGG----ASGKL-MAILRRF GCPFGP--TCG---------- A_0025_336 MEKLTILFLVAAVLLSTQVMVQGDGDQPA-------ERDAVPRDDNSGG----TSGKF-MNALRQS GCPWKP--WCG---------- V_1258_064 MGKLTILVLVAAVLLSSQVMVQGDGDQPA-------DRNAVPRDDNPGG----TSGKF-MNALRRS GCPWDP--WCG---------- V_CG13_128 MEKLTILFLVAVVLLSTQVMVQGDGDQPA-------ERDAVPRDDNSGG----TSGKFIMNALRRS GCPWKP--WCG---------- V_1302_158 ----------------------GDGDQPA-------ERDAVPRDDNSGG----TSGKFIMNALRRS GCSWQP--WCG---------- V_CG13_129 MEKLTILFLVAVVLLSTQVMVQGDGDQPA-------ERDAVPRDDNSGG----TSGKF-MNALRRA ICPWSP--WCG---------- A_0885_011 ----------------------GDGDQPA-------DRDAVPRDDNPGG----TSGKF-MNAQRRS GCPWEP--WCG---------- A_1387_337 ---------------------------------------AVPRDDNPGG----TSGKF-MNAQRRS GCPWEP--WCG---------- A_0520_281 MEKLTILVLVAAVLLSTQVMVQGDGDQPA-------DRDAVPRDDNPGG----TSGKF-MNAQRRS GCPWEP--WCG---------- A_0048_300 ----------------------GDGDQPA-------DRDAVPRDDNPGG----TSGKF-MNAQRRS GCPWEP--WCG---------- A_1387_336 MEKLTILVLVAAVLLSTQVMVQGDGDQPA-------DRDAVPRDDNSGG----TSGKL-MKALRQR DCPWHS--WCG---------- A_0520_277 MEKLTILVLVAAVLLSTQVMVQGDGDQPA-------DRDAVPRDDNSGG----TSGKL-MKALRQP GCPWEP--WCG---------- A_0520_278 MGKLTILFLVAAVLLSTQVMVQGDGDQPA-------DRDAVPRGGTSSG----TSGKL-MKALRQS DCPWNP--WCG---------- A_0520_279 MGKLTILFLVAAVLLSTQVMVQGDGDQPA-------DRDAVPRGGTSSG----TSGKL-MKALRDG DCPWNP--WCG---------- A_0055_196 MEKLTILVLVAAVLLSTQVMVQGDGDQPA-------DRDAVPRDDNSGG----TSGKL-MKALRDG DCPWNP--WCG---------- A_0039_103 MEKLTILFLVAAVLLSTQVMVQGDGDQPA-------DRDAVPRDDNSGG----TSGKL-MKALRQP GCPWKP--------------- A_0520_275 MEKLTILVLVAAVLLSTQVMVQGDGDQPA-------DRDAVPRDDNSGG----TSGKL-MKALRDG DCPWNP--WCG---------- A_0048_240 MEKLTILVLVAAVLLSTQVMVQGDGDQPA-------DRDAVPRDDNSGG----TSGKL-MKALRDG DCPWNP--WCG---------- A_0048_241 MEKLAILVLVAAVLLSTQVMVQGDGDQPA-------DRDAVPRDDNSGG----TSGKL-MKALRDG DCPWNP--WCG---------- V_CG13_131 MGKLTILVLVAAVLLSSQVMVQGDGDQPA-------DRNAVPRDDNPGG----ASGKL-MAILRRS GCPWDP--WCG---------- V_CG13_133 MGKLTILVLVAAVLLSSQVMVQGDGDQPA-------DRNAVPRDDNPGG----ASGKL-MAILRRS GCPWHP--WCG---------- V_1302_206 MGKLTILVLVAAVLLSSQVMVQGDGDQPA-------DRNAVPRDDNPGG----ASGKL-MAILRRS GCPWHP--WCG---------- V_1258_065 MGKLTILVLVAAVLLSSQVMVQGDGDQPA-------DRNAVPRDDNPGG----ASGKL-MAILRRS GCPWHP--WCG---------- V_1302_208 MGKLTILVLVSAVLLSSQVMVQGDGDQPA-------DRNAVPRDDNPGG----ASGKL-MAILRRS GCPWHP--WCG---------- V_CG13_134 ----------------------GDGDQPA-------DRNAVPRDDNPGG----ASGKL-MAILRRS GCPWKP--WCG---------- V_1302_161 MEKLTILFLVAAVLLSTLVMVQGDGEQPA-------DRNAVPRDDNPGG----ASGML-MAILRRS GCPWHP--WCG---------- V_1278_050 ----------------------GDGDQPA-------DRDAVPRDDNPGG----AIGKF-MNVLRRS GCPWEP--WCG---------- A_0885_012 -------LLVAAVLLSTQVMVQGDGDQPA-------YRNAAPRDDNPGG----AIGKF-MNVLRRS GCPWEP--WCG---------- A_0025_337 MGKLTILLLVAAVLLSTQVMVQGDGDQPA-------YRNAAPRDDNPGG----AIGKF-MNVLRRS GCPWEP--WCG---------- A_0875_103 MEKLTILFLVAAVLLSTQVMVQGDGDQPA-------YRNAAPRDDNPGG----AIGKF-MNVLRRS GCPWEP--WCG---------- K_0010_128 MEKLTILVLVAAVLLSTQVMVQGDGDQPA-------DRDAVPRDDNSGG----TSGKL-MKALRQR DCPWHS--WCG---------- K_0010_230 MEKLTILVLVAAVLLSTQFMVQADGDQPA-------DRDAVPRDDNPGR----TSGKF-LHAKRRS GCPWEP--WCG---------- K_0010_233 MYKLTILVLVAALLLSTQVMFQGDGDQPA-------DRDAVPRDDNPGG----TSGKF-MN----- --------------------- K_0010_397 MEKLTILVLVAAVLLSTQVMVQGDGDQPA-------DRDAVPRDDKPGG----TSGKF-MNAQRRS GCP------------------ K_0010_344 --KLTILVLGAAVLLSTQVMVQGDGDQPA-------DRDAVPTEDNPGG----TSGQF-MNAQRRS GCP------------------ K_0010_127 ------------------------GDQPA-------DRHAVPRDDNPGG----TSGKF-MNAQRRS GCPWEP--WCG---------- K_0010_231 MEKLTILVLVAAVLLSTQVIVQGEGDQPA-------YLEAVPKDDNPGG----RSGKF-MNAQRRS GCPWEP--WCGLSESTIAITA K_0010_232 ----------------------GDGDQPA-------ARDAVPRDDNPGR----KSGKF-MNGQSRY GCPWEH--WCG---------- radiatusP58786 MGKLTILVLVAAVLLSAQVMVQGDGDQPA-------DRNAVPRDDNPGG----ASGKF-MNVLRRS GCPWEP--WCG---------- virgoADZ74135 MGKLTILVLVAAVLLSTQVMVQGDGDQPA-------DRNAVRRDDNPGG----LSGKF-MNVLRRS GCPWHP--WCG---------- ermineusAXL95473 MGKLTILLLVAAVLLSTQVMVQGDGDQPA-------YRNAAPRDDNPGG----AIGKF-MNVLRRS GCPWEP--WCG---------- purpurascensP58784 MGKLTILVLVAAVLLSTQVMVQGDGDQPA-------YRNAAPRDDNPGG----AIGKF-MNVLRRS GCPWDP--WCG---------- ebraeusAPX52854 MGKLTILVLVAAVLLSTQVMVQGDADQPA-------DRDAVPRDDNPGG----TSGKL-MNVLIRS GCPWHP--WCG---------- magusQFQ61088 MGKLTILVLVAAALLSTQVMVQGDGDQPA-------DRDAVPRDNIPGG----TSEKF-MNVLQRR GCPWKP--WCG---------- geographusBAO65573 MGKLTILVLVAAVLLSTQAMVQGDGDQPA-------ARNAVPRDDNPDG----PSAKF-MNVQRRS GCPWEP--WCG---------- betulinusAGE10523 MEKLTILVLVAAALLSTQVMVQGDGDHLA-------DRDAVPRDDNPGG----TREKI-MNALRRF GCPPGL--WCG---------- gloriamarisGFNK01000066 MGKLTILFLVAAALLSTQVMAQGDGDQPV-------DRDAVPRDDDSGG----TIEKF-MNLLRQV RCRWTP--ACG---------- [ /--------Signal-------/---------Pro------------------------------/ /-----C--C/---------- A_0055_198 MEKLTILVLVAAVLL-TQVMVQGDGDQPA-------DRDAVPRGPASFG----TSGKL-MKALHRT GRPYGPCSYCG---------- A_0239_066 MEKLTILVLVAAVLLSTQVMVQGDGDQPA-------DRDAVPRGG---G----TSGKL-MKALHRT GRPYGPCSYCG---------- A_0025_335 MEKLTILFLVAAVLLSTQVMVQGDGDQPA-------DRDAVPRGG---G----TSGKL-MKALHRT GRPYGPCSYCG---------- A_0520_280 MGKLTILFLVAAVLLSTQVMVQGDGDQPA-------DRDAVPRGGTSSR----TSGKL-MKALHRT GRPFGPCSHCG---------- [ /--------Signal-------/---------Pro------------------------------/ /--------C/---------- A_0855_106 MEKLTILFLVAAVLLSTQAMVQGDGDQPAERDAVPRERDAVPRDDNSGG----TSGKL-MKALHRT GRPFGSGSHCG---------- A_0885_119 MEKLTILVLVAAVLLSTQVMVQGDGDQPAERDAVPRERDAVPRDDNSGG----TSGKL-MKALHRT GRPFGPGSICG---------- A_0039_105 MEKLTILFLVAAVLLSTQVMVQGDGDQPA-------DRDAVPRDDNSGG----TSGKL-MKALHRT GRPFGSGSHCG---------- A_0885_121 MEKLTILFLVAAVLLSTQVMVQGDGDQPA-------ERDAVPRGRAFCG----TSGKL-MKALHRT GRPFGPGSICG---------- A_0875_104 MEKLTILFLVAAVLLSTQVMVQGDGDQPA-------DRDAVPRGRAFCG----TSGKL-MKSLHRT GRPFGPGSICG---------- A_0039_104 MEKLTILVLVAAVLL-TQVMVQGDGDQPA-------DRDAVPRGPASFG----TSGKL-MKALHRT GRPYGPCSHCG---------- A_0031_411 MEKLTILVLVAAVLLSTQVMVQGDGDQPA-------DRDAVPRDDNSGG----TSGKL-MKALHRT GRPFGSGSHCG---------- A_1387_335 MEKLTILVLVAAVLLSTQVMVQGDGDQPA-------DRDAVPRGRALCG----TSGKL-MKALHRT GRPFGSGSHCG---------- K_0010_343 MEKRTILVLVAAVLLSTQVMVQGDGDQPA-------DRDAVPTEDNPGG----TSGQF-MNAQRRS GCP------------------ K_0010_229 MEKLTIMVVVADVLLSNQVMVQGDGDQPA-------DRDPVPRDDNPAG----TSGKF-M------ --------------------- K_0010_345 MEKLTILVLFAAVLLSTHVMVQGDGDQPS-------DRDAVPRDYNPGG----TSGKF-MKGELLS GGPWEPWCC------------ A_0239_067 MEKLTILVLVAAVLLSTQVMVQGDGDQPA-------DRDAVPRGG---G----TSGKL-MKALHRT GRPFGSGSHCG---------- A_0031_408 MEKLTILVLVAAVLLSTQVMVQGDGDQPA-------DRDAGPRGG---G----TSGKL-MKALHRT ERPFGPGSHCGRRCGKRSTLQ V_1302_336 MGKLTILVLVAAVLLPSQVMVQGVGDQPA-------DRNAV------------------------- --------------------- A_0239_063 MGKLTILVLAAAVLLSSQVMVQGDGDQPA-------DRNAVPRDDNPGG----ASGKL-MAILRRF GCPFGP--TCG---------- V_1302_335 ------------------------ADQPA-------ERDAVPRDDSGGGTACGTSGKL-MKALHPT GRPFGP--PCG---------- V_CG13_130 MEKLTILFLVAAVLLSTLVMVQGDGDQPA-------ERDAVPRDDSGGGTACRTSGKL-MKALHRT GRPFGP--LCG---------- V_CG13_132 MEKLTILFLVAAVLLSTQVMVQGDGDQPA-------ERDAVPRDDSGGGTACRTSGKL-MKALHRT GRPFGP--LCG---------- V_1278_051 MEKLTILVLVAAVLLSTLVMVQGDGDQPA-------ERDAVPRNDSGGGTARRTSGKL-MKALHRT GRPFGP--ICG---------- V_1258_063 MEKLTILVLVAAVLLSTLVMVQGDGDQPA-------ERDAVPRNDSGGGTARRTSGKL-MKALHRT GRPFGP--LCG---------- V_1302_159 MEKLTILFLVAAVLLSTLVMVQGDGDQPA-------ERDAVPRDDSGGGTACGTSGKL-MKALHPT GRPFGP--PCG---------- V_1302_162 MEKLTILFLVAAVLLSTLVMVQGDGDQPA-------ERDAVPRD----GTACGTSGKL-MKALHPT GRPFGP--PCG---------- [Superfamily O3-1] [Framework VI/VII] [ /------Signal------/------------Pro----------/ /----C---C------CC--------C---C-] A_0055_108 MSGLEIIVLTLLLLVSMATSHQDRGEKQATQRDAINVRRRRSITRG AVTEACKEHCEDQDKKCCGLTNGSPRCAGICLG A_0855_046 MSGLEIMVLTLLLLVSMATSHQDRGEKQATQRDAINVRRRRSITRG AVTEACKEHCEDQDKKCCGLTNGSPRCAGVCLG A_0875_043 ISGLEIMVLTLLLLVSMATSHQDRGEKQATQRDAINVRRRRSITRR AVTEACEEHCEDQDKKCCGLTNGIPRCAGICLG A_0039_023 MSGLEIMVLTLLLLVSMATSHQDRGEKQATQRDAINVRRRRSITRR AVTEACKEHCEDQDKKCCGLTNGSPTCARFCLG A_0039_024 MSGLEIMVLTLLLLVSMATSHQDRGEKQATQRDAINVRRRRSITRR AVTEACKEHCEDQDKKCCGLTNGSPTCAKICFG V_1278_097 MSGLGIMLLTLLLLVFMATSHQDAGEKQATQRDAINVRRRRSITRR VVTEACEEYCEDRDKTCCGLENGQPDCATLCLG V_CG13_155 MSGLGIMVLTLLLLVSMATSHQDGGEKQATQRDAINVRRRRSITRR VVTEACKEYCEDRDKNCCGQTNGQPTCATICLG V_1302_058 ------------LLVSMATSHQDGGEKQATQRDAVNVRRRRSISRR VVTEACDEYCEDRDKNCCGLTNGQPFCAVLCFG V_1258_103 ------------LLVSMATSHQDGGEKQATQRDAVNVRRRRSITRR VVTEACDEYCEDRDKNCCGLTNGQPSCAVLCFG V_1302_056 MSGLEIMVLTLLLLVSMATSHQDGGEKQATQRDAVNVRRRRSISRR VVTEACKEYCEDRDKNCCGQGNDGPRCAGVCFG A_0025_302 MSGLRIMVLTLLLLVSMATSHQDRGEKQATQRDAINVRRRRSITRR AVTEACKEHCGDQGKKCCGQTNGRPRCASICFG A_0520_074 MSGLEIMVLTLLLLVSMATSHQDRGEKQAMQRDAINVRRSRSITRR AVTEACKEHCEGQDKKCCGLTNGRPTCARACFG A_0048_025 MSGLEIMVLTLLLLVSMATSHQDRGEKQATQRDAINVRRRRSITRR VVTEACKEHCEDHDKKCCGLTNGRPTCASACLG A_1387_170 MSGLEIMVLTLLLLVSMATSHQDRGEKQATQRDAINVRRRRSITRR VVTEACKEHCEDQDKKCCGQTNGTPTCAGVCLG A_0025_303 ----------LLLLVSMATSHQDRGEKQATQRDAINVRRRRS---- ---EGCTERCEAQDKHCCGVINERPRCAQICYG K_0010_086 MSGLGIMLLTLLLLVFMATSHQDAGEKQATQRNAINVRRRRSITRR VVTEECDEYCEDRDKTCCGLENGQPDCATLCLG tessulatusQ9BP73 MSGLGIMVLTLLLLVFMATSHQDAGEKQATQRDAVNVRRRRSIAGR TTTEECDEYCEDLNKNCCGLSNGEPVCATACLG betulinusAMP44738 MSGLGIMVLTLLLLVIMATSHQDAGEKQMTQRDAINVRRRRSITGR VVTEACEETCELEEKNCCGITNGQPFCFFPCFG distansAGG19150 MSGLGFMVLTLLLFVPMATSQQDGGEKQAMQRDAINVAPGTSIIGT ETNQECIDICKQEDKNCCGKSNGVPTCGKICLG ventricosusQ9BP60 MSGLGIMVLTLLLLVSMATSHQDGRGKQATQRDAINVRRRRSITR- --TEACYEYCKEQNKTCCGISNGRPICVGGCIR magusQFQ61091 MSGLGIVVLTLLLLVSMATSHQDRGEKQAMQRDAINVIRR-SVIRR QVTEACEEACEAVKMHCCDVSDGTTKCVTRCLG [New Framework] [ /------Signal------/------------Pro----------/ /----C---C------CCC-------C---C-----C] A_0025_300 MSRLGIMVLTFLLLVSMATSHRYARWKQATRRDAINVRRR-SRRSR PKTEACEEVCELEEKHCCCIRSDGPKCSRMCLLSFFC ermineusAXL95474 MSRLGIMVLTFLLLVSMATSHRYARWKQATRRDAINVRRR-SRRSR PKTEACEEVCELEEKHCCCIRSDGPKCSRMCLLSFFC geographusBAO65634 MSGLGIMVLTLLLLVSMAISHRYAREKQATRRDVVNIRRR----SK PKTPECKRICKLEEKKCCCVRSEGPKCSRLCGLPMFC [Superfamily O3-2] [Framework VI/VII] [ /-------Signal-----/--------Pro------/ /C-----C-----CC----------C---C---] V_1258_104 MSGLRIMVLTLLLLVSMATSHQDRGVGQLMPRNGLQER TCTSPADC-GDLQCCPDTVDEPEGRCDSDCTI-S V_1302_057 MSGLRIMVLTLLLLVSMATSHQDRGVGQLMPRNGLQER TCTSPADC-GDLQCCPDTVDEPEGRCDSDCTI-S V_1278_011 MSGLRIMVLTLLLLVSMATSHQDRGVGQLMPRNGLQER TCTSPADC-GDLQCCPDTVDKPEGRCDSDCTI-S V_CG13_154 MSGLRIMVLTLLLLVSMATSHQDTGVGQLMPRNGLQER TCTSPADC-GDLQCCPDTVDKPEGRCDSDCTI-S A_0875_045 MSGLRIMVLTLLLLVSMATSHQDAGVGQLMPRNGLQER TCTSRSDCPEGQTCCSGNVLDQEGFCTGDCRILV V_CG13_156 MSGLAIMVLTLLLLVSMATSHQDAGVGQLMPRNGLQEG TCTSTADCPMGQECCPDNVAGHEGFCVDDCVI-Y A_0239_123 MSELRVMVLILLLLVSMATSHQDAGVGQLMPRNGLQER TCTSSSDCPMGQTCCSGNVLDQVGFCTGDCPILV A_0055_106 MSGLRIMVLTLLLLVSMATSHQDRGVGQLMPRNGLQER TCTSSSDCTAGRECCPFRVDEPEGFCTDDCVI-H A_0039_025 MSGLRIMVLTLLLLVSMATSHQDRGVGQLMPRNGLQER TCTSSSDCPTGQECCPNTVDGSEGFCTDDCVI-Y A_0055_107 MSGLRIMVLTLLLLVSMATSHQDRGVGQLMPRNGLQER TCTSSSDCPTDHECCLSRVDGSDGICDDECVI-Y A_0855_045 MSGLRIMVLTLLLLVSMATSHQDRGVGQLMPRNGLQER TCTSSSDCPTGQECCPDRVDEPEGFCTDDCVI-H A_0875_044 MSGLRIMVLTLLLLVSMATSHQDRGVGQLMPRNGLQER TCTSSSDCPTGQKCCPDRVDEPEGFCTDDCVI-H A_0025_301 MSGLRIMVLTLLLLVSMATSHQDRGVGQLMPRNGLQER TCTSSSDCPTGQECCPNTVDGSEGFCTDDCVI-Y A_0520_072 MSGLRIMVLTLLLLVSMATSHQDRGVGQLMPRNGLQER TCTSSSDCPTGQECCPDSVDGSEGFCVDECVI-Y A_1387_171 MSGLRIMVLTLLLLVSMATSHQDRGVGQLMPRNGLQER TCTSSSDCPTGQECCPDSVDEPEGFCVDDCVI-Y A_0239_267 MSGLRIMVLTLLLLVSMATSRQDRGVGQLMPRSGLQER TCTSSSDCPTDHECCLSRVDGSDGICDDECVI-Y K_0010_087 MSGLRIMVLTLLLLVSMAASHQDRGVGQLMPRNRLQER TCTSPADCGDQQ-CCPDTVNKPEGRCDTDCTI-Y ermineusAXL95602 ------------LLVSMATSHQDRGVGQLMPRNGLQER TCTSSSDCPTGQECCPDRVDEPEGFCTDDCVI-H ermineusAXL95398 MSRLGIMVLTLLLLVFMATSRQDRGVKRLMLRNKLQKR TCSSPSNCPTGQECCPDRVDEPEGFCTDECNI-Y eburneusADZ99332 MSGLGIMVLTLLLLVFMATSHQHRGGKQLMLRNNLQKR TCSSPSNCPTGQECCPDKVDEPEGFCADECII-T betulinusAMP44737 MSGLGIMVLTLLLLVFMATSHQDAGVKRLILRNKLQER TCSSPSDCPAGQECCPDKLDEPEGFCINDCII-T distansAGE10529 MSGLGFMVLTFLLLVSMATSKQDGRVRRRMLHTRLVEG ACTSPSNCPTGQECCPDKLDEPEGSCANSCPF-Y [Superfamily O3-WF] [No Signal, no Framework] V_CG13_001 MSGLGIMLLALLFLVSLETSLQDGGEGQAMLRDKNPQGSRKVLLRRTLQKLRQPPRGTKKSASLDFLVTAFVA V_1302_005 MSGLGIMLLALLFLVSLETSLQDGGEGQAMLRDKNPQGSRKVLLRRTLQKLRQPPRGTKKSASLDFLVTAFVA V_1258_051 MSGLGIMLLALLFLVSLETSLQDGGEGQAMLRDKNPQGSRKVLLRRTLQKLRQPPRGTKKSASLDFLVTAFVA V_1278_076 MSGLGIMLLALLFLVSLETSLQDGGEGQAMLRDKNPQGSRKVLLRRTLQKLRQPPRGTKKSASLDFLITAFVA A_0885_073 MSGLGIMLLALLLLVSLETSLQDGGEGQAMLRDKNPQGSRKILLRRTLQKLRQPPRGTKKSASLDCLVTAFVA A_0875_117 MSGLGIMLLALLLLVSLETSLQDGGEGQAMLRDKNPQGSRKVLLRRTLQKLRQPPRGTKKSASLDCLVTALVA A_0055_053 MSGLGIMLLALLLLVSLETSLQDGGEGQAMLCDKNPQGSRKVLLRRTLQKLRQPPRGTKKSASLDCLVTAFVA A_0039_010 MSGLGIMLLALLLLVSLETSLQDGGEGQAMLRDKNPQGIRKVLLRRTLQKLRQPPRGTKKSASLDCLVTAFVA A_0855_084 MSGLGIMLLALLLLVSLETSLQDGGEGHAMLRDKNPQGSRKVLLRRTLQKLRQPPRGTKKSASLDCLVTAFAA A_0239_016 MSGLGIMLLALLLLVSLETSLQDGGEGQAMLRDKNPQGSRKILLRRTLQKLRQPPRGTKKSASLDCLVTAFVA A_0031_042 MSGLGIMLLALLLLVSLETSLQDGGEGQAMLRDKNPQGSRKILLRRTLQKLRQPPRGTKKSASLDCLVTAFVA A_0048_006 MSGLGIMLLALLLLVSLETSLQDGGEGQAMLRDKNPQGSRKVLLRRTLQKLRQPPRGTKKSASLDCLVTAFVA A_0520_211 MSGLGIMLLALLLLVSLETSLQDGGEGQAMLRDKNPQGSRKALLRRTLQKLRQPPRGTKKSASLDCLVTAFVA A_0025_225 MSGLGIMLLALLLLVSLETSLQDGGEGQAMLRDKNPQGSRKVLLRRALQKLRQPPRGTKKSASLDCLVTAFVA A_1387_101 MSGLGIMLLALLLLVSLETSLQDGGEGQAMLRDKNPQGSRKVLLRRTLQKLRQPPRGTKKSASLDSLVTAFVA ermineusAXL95644 MSGLGIMLLALLLLVSLETSLQGGGEGQAMLRDKNQQGSRKILLRRALQKLRKPPRGTKKSASLHFMAAAFVA gloriamarisGFNK01000068 MSGLGIMLLALLLLVSLETSLQGGGEGQAMHRDKNQQGHRRILLRRALQKSRTPPQGTKKSASLDFLVPVVLA magusQFQ61093 MSGLGIMLLALLLLVSLETGLPGGGEGQAMSRDKNPQGSRKILLRRALQRLRKPPRGTKKSASHDFPLTAFVA [Superfamily P-1a] [Framework IX] [ /---------Signal----------/----------------Pro---------------/ /-C----C-----C----C--C------C----] A_0520_070 -----------------------GVQTGQITRDVDNGQLTDNGRNLQSQWKPMTLFKSLYKR SSC-GESCRGDGDCS-TDCPFCSSNLLKCM---- A_0048_089 MHLSLAGSAVLMLLLLFALGNFVGVQTGQITRDVDNGQLTDNGRNLQSQWKPMTLFKSLYKR SSC-GESCRGDGDCS-TDCPFCSSNLLKCM---- V_1302_155 -----------------------GVQPGEITRDVDNGLPTDNRRNLQSQWKPMTLFKSLYKR SGC-GEDCGGDADCP-TDCPYCTLNLNKCM---- K_0010_144 MHLSLAGSAVLMLLLLFALGNFVGVQTGQITRDVDNGQLTDNGRNLQSQWKPMTLFKSLYKR SSC-GESCRGDGDCS-TDCPFCSSNLLKCM---- A_0855_059 MHLSLADSAVLMLLLLFALGNFAGVQPGEITRDVDSGLPTDNRRNLQSQWKPTTLFRSLYKR AGC-GEDCGGDADCPTTGCPYCTLDLNKCM---- A_1387_092 MHLSLAGSAVLMLLLLFALGNFAGVQPGEITRDVDNGLPTDNRRNLQSQWKPTTLFRSLYKR AGC-GEDCGGDADCPTTGCPYCTLNLNKCM---- A_0031_260 ----------------------------EITRDVDSGLPTDNRRNLQSQWKPTTLFRSLYKR AGC-GEDCRGDGDCPTTGCPYCTLYKNKCM---- A_0039_143 --------------LLFALGNFAGVQPGEITRDVDSGLPTDNRRNLQSQWKPTTLFRSLYKR AGC-GEDCGVDEDCPTTSCPYCTLNLNQCM---- A_0239_077 MHLSLAGSAVLMLLLLFALGNFAGVQPGEITRDVDSGLPTDNRRNLQSQWKPTTLFRSLYKR AGC-GEDCGGDADCPENGCPFCTLYQNICM---- A_0875_051 ---------------LFALGNFAGVQPGEITRDVDSGLPTDNRRNLQSQWKPTTLFKSLYKR AGC-GEDCGGDADCPENGCPYCTLFLNICM---- K_0010_125 -HLSLAGSAVLMLLLLFA---FVGVQPGQITRDVDNGQLTDNRGNLQSQRKPVTFFKSLDKR ---------------------------------- flavidusAFU50766 MHLSLAGSAVLMLLLLFALGNFVGVQTGQIARDVDNGLLTDKHRDLQSLRKPMDFFKSLYKR SSC-GEDCWGDADCP-NDCPYCVSNLSKCM---- betulinusAMP44805 -------------------------------RDVDNGQLTDNRRNLRSQRKPMTLIKSLYKR SSC-GEPCGRDEDCP-SNCPYCTLNLSKCM---- ermineusAXL95578 MHPSLAGSAVLMLLLLFALGNFVGVQSGQIARDADNGQLKDDRRNLQSQRKPMTLFKSLYKR SSC-TEPCIKDTDCT-TDCTICLKNLSKCM---- gloriamarisGFNK01000069.1 MHLSLARSAVLMLLLLFALGNFVVVQSGLITRDVDNGQLTDNRRNLQTEWNPLSLFMS---R RSC-NNSCQSHSDCA-SHC-ICTFRG--CGAVNG betulinusAMP44742 MHLSLAGSAVLMLLLLFAFGTFVGVQSGQITRDVDNGQLTDDRRNLQSLWKQMTLFRSLYKR TNC-GEACLKDEQCV-GACQICVPSQLKCL---- praecellensATF27735 MHLSLAGSAVLMLLLLFALGNFVGVQPGQITRDVDNGQLTDNRLNLQSQWKPVSLFKSLYKR RPC-YGSCENNSHCN-RFC-YCRNKK--CK---- andremeneziATF27493 MHLSLAASAVLMLLLLFALGNFVGVQPGQMTRDVDNGQLTDNRRNLQSRWKPMSLFKSLDKR TPC-HELCELTSDCN-KEC-HCYKNQ--CHHH-- imperialisAME17680 MHRSLAGSAVLMLLLLFALGNFVGVQPGLVTRDADNGQLMDNRRNLRLERKTMSLFKSLDKR ADC-STYCFGMGICQ-SGC-YC-GPGHACMPNGR magusQFQ61095 MHLSLAGSAVLMLLLLFTLGNFVGIQSGQITRDMDSGQLRDDRRNPQSQWKPRTLVK---K- SSC-KKSCTKDGDCK-YSCTKC-THLSKCM---- K_0010_461 -------------------------------RDVENGKLTDNGRNMQSQWKPMSLFKSLDKR ASC-GGGCANSPDCP-SSCNTCHDAY--CK---- A_0855_070 --LSLARSAVLMLLLLFALGNFVGVQPGHITRNVDNGQLTDNGRNLQSQRKPVSLFKSLDER GSC-GGTCTISSDCP-STCSTCLDAQ--CT---- V_CG13_074 MHLSLARSAVLMLLLLFAMGNFVGVQPGQITRDVDNRQLTGNRRNLQSRWMPMSLFKSLDER GSC-GGTCTTSSECP-STCNTCLHAQ--CV---- V_CG13_076 MHLSLARSAVLMLLLLFAMGNFVGVQPGQITRDVDNRQLTGNRRNLQSRWMPMSLFKSLDER GSC-GGTCTTSSECP-STCNTCLHAQ--CT---- V_1302_156 MHLSLARSAVLMLLLLFAMGNFVGVQPGQITRDVDNRQLTDNRRNLQSRWMPMSLFKSLDER GSC-GGTCTTSSECP-STCNTCLHAQ--CT---- V_1302_157 MHLSLARSAVLMLLLLFATGNFVGVQPGQITRDVDNRQLTDNRRNLQSRWMPMSLFKSLDER GSC-GGTCTTSSECP-STCNTCLHAQ--CT---- V_1258_006 MHLSLARSAVLMLLLLFAMGNFVGVQPGQITRDVDNRQLTDNRRNLQSRWMPMSLFKSLDER GSC-GGTCTTSSECP-S----------------- A_0039_142 MHLSLARSAVLMLLLLFALGNFVGVQPGQITRNVDNGQLTDNGRNLQSRRKPVSLFKSLDER GSC-GGSCTISSDCP-STCNTCFHAQ--CT---- A_0031_257 MHLSLARSAVLMLLLLFALGNFVGVQPGQITRNVDNGQLTDNGRNLQSRRKPVSLFKSLDER GSC-GGSCTISSDCP-STCNTCLHAQ--CT---- A_1387_194 MHLSLARSAVLMLLLLFALGNFVGVQPGQITRNVDNGQLTDNGRNLQSRRKPMSLFKSLDER GSC-GGTCTTSSECP-STCNTCLDAE--CT---- betulinusAMP44743 -----------MLLLLFALGNFVGVQPEQMTRDVDNGQLTDNRDDLQSQWKPMSLFKSLDKR G-C-GGVCAYGSECP-SSCNTCYSAQ--CTAM-- V_CG13_075 MHLSLARSAVLMLLLLFAMGNFVGVQPGQITRDVDNRQLTDNHRNLQSRWMPMSLFKSL-ER GSC-GGGCTTDAHCA-SDCE-CWDAQ--CSEGP- A_0885_074 MHLSLARSAVLMLLLLFALGNFVGVQPGQITRDVDNRQLTDNRRNLQSRWKPMSLFKSL-KR GSC-GGGCMIDADCD-SQCE-CWDAQ--CLEGP- A_0055_125 ---------------LFALGNFVGVQPGQITRDVDNRQLTDNRRNLQSRWKPMSLFKSL-KR GSC-GGSCTSSAHCD-SQCE-CWDAQ--CSEGP- A_0855_061 MHLSLARSAVLMLLLLFALGNYLGVQPGQITRDVDNRQLTDNRRNLQSRWKPMSLFKSL-KR GSC-GGGCTSDPDCE-SHCE-CWDAQ--CSDGP- A_1387_195 MHLSLARSAVLMLLLLFALGNFVGVQPGQITRDVDNRQLTDNRRNLQSRWKPMSLFKSL-KR GSC-GGGCMTDADCD-SQCE-CWDAQ--CSEGP- A_0885_160 ---------------LFALGNFVGVQSGQITRDADNGQLTDKQSNLQSLMKPMSPLRSVAKR LMC-GDVCSGDHQCP-LYCTYCSPIN-GCISE-- A_0875_052 ---------------LFALGNFVGVQSGQITRDADNGQLTDKQSNLQSLMKPMSPLRSVAKR LMC-GDVCSGDHQCP-LYCIYCSPIN-GCISN-- A_0875_053 MHLSLARSALLMLLLLFALGNFVGVQSGQITRDADNGQLTDKQSNLQSLMKPMSPLRSVAKR LLC-GDICSGDHQCP-LYCTYCSPRN-GCVEKW- A_0025_116 -------------------------------------------------RKPMTLLRSLGKR VGC-GKRCRDHDQCR-SDCSVCSQLN-GCISDWR A_0520_069 MHLSLARSAHLMLLLLFALGNFVGVQSGQITRDADNGQLTDKQSNLQSLMKPMTLLRSLGKR AQC-GKPCSDDDDCP-LYCRYCSPIN-GCISDWR A_0239_076 MHLSLARSALLMLLLLFALGNFVGVQSGQITRDADNGQLTDKQSNLQSLMKPMTLLRSLDKR AEC-GKPCSDDDDCR-PYCSYCSPKN-GCRDGWS A_0031_258 MHLSLACSALLMLLLLFALGNFVGVQSGQITRDADNGQLTDKQSNLQSL------------- ---------------------------------- [Superfamily Q-1a] [Framework VI/VII] [ /------Signal-------/--------------Pro--------------/ /C--C----CC-----C-------------C-----/-------------------] A_0855_088 MHTLEMMLLILLLLPLAHGEGAGRAVGGDRSPSEARRTYKRLLERPARRMDRR DCTPCGSTLCCSLGLRCGTSTFHESFGEPACV------------------------- V_1258_139 MHTLEMMLLILLLLPLAPGEGAGRAVGGNRSPSEARRTYKRPLERPARRMDRR DCTPCGPDLCCSPGLRCGTSTHHDTYDEPACLNY----------------------- V_1302_143 MHTLKMMLLILLLLPLAPGEGAGRAVGGNRSPSEARRTFKRLLQRPARRMDRR DCTPCGPDLCCSPGLRCGTSTHHDTYGEPACLNY----------------------- V_CG13_082 MHTLEMMLLILLLLPLAPGEGAGRAVGGNRSPSEARRTYERLLETPARRMDRT DCTPCGPDLCCSPGLRCGTSTRQGHYGEPACLNY----------------------- V_1258_140 MHTLEMMLLILLLLPLAPGEGAGRAVGGNRSPSEARRTYERLLETPARRMDRT DCTPCGPDLCCSPGLRCGTSTRQGHYGEPACLNY----------------------- V_1278_043 MHTLEMMLLILLLLPLAPGEGAGRAVGGNRSPSEARRTYKRPLERPARRMDRT DCTPCGPDFCCSSGSRCGPSTHHETFGEPACLHY----------------------- A_0520_314 MHTLEMMLLILLLLPLAPGEGAGRAVGGDRSPSEARRTYKRLLERPARRMDRR DCTPCGPNLCCSPGLRCGTSTHHDTFGELACV------------------------- A_0031_131 MHTLKMMLLILLLLPLAPGEGAGRAVGGDRSPSEARRTYKRLLERPARRMDRR DCTPCGPNLCCSPGLRCGTSTHHDTFGEPACV------------------------- A_0025_049 MHTLEMMLLILLLLPLAPGEGAGRAVGGDRSPSEARRTYKRLLERPARRMDRR DCTPCGPNLCCSPGLICGTSTHHDTFGEPACV------------------------- A_0885_095 MHTLEMMLLILLLLPLAPGEGAGRAVGGDRSPSEARRTYKRLLERPARRMDRS DCTPCGSNLCCSRGFRCGISSFQKTFGKLACVSSY---------------------- A_0048_149 MHTLEMMLLILLLLPLAPGEGAGRAVGGDRSPSEARRTYKRFLERPARRMDRR TCEPCAPNLCCEDGYRCGTSTNHQHYGEPACLSY----------------------- A_0875_131 -----------------------------------RRTYKRLLQRPARLMDRR GCKPCAPGLCCEEGWDCETAKHHSVQGEPACIRNY---------------------- A_1387_134 MHTLKMMLLILLLLPLAPGEGAGRAVGGNRSPSEARRTYKRLLQRPARLMDRR GCTPCAPGLCCEEGYDCGIAEHHSVQGEPACIRNY---------------------- A_0055_072 -----------------------------------RRTYKRLLQRPARLMDRR DCTPCAPNLCCEEGYRCGTAEHHSVHGEPACIRNYY--------------------- V_1302_144 MHTLKMMLLILLLLPLAPGEGAGRAVGGNRSPSEARRTFKRLLQRPARRMDRR ACTPCAPNLCCEEGYDCGTSTHHSHYGEPACIRNYY--------------------- A_0031_129 MHTLKMMLLILLLLPLAPGEGAGRAVGGNRSPSEARRTYKRLLQRPARLMDRR DCTPCGSDLCCEEGYDCGTSTHHSNHGEPACIRNYY--------------------- A_0048_344 -------------------------VGGNRSPSEAGRTYKRLLERPAMLMDRR DCTPCAPDLYCEEGYRCGTAEHHSVYGEPACIRNYY--------------------- A_0048_151 MHTLEMMLLILLLLPLAPGEGDGRAVRGDRNPNEASRTYKRLLQRPARRMD-- --------------------------------------------------------- A_0885_044 -----------------------------------RRTYKRLLQRPARLMDRS DCTPCAPDLCCEEGYHCGTSTHHSNHGEPACIRHSAAKKDIDVEQRSITPFMAGLRV A_0031_130 MHTLKMMLLILLLLPLAPGEGAGRAVGGNRSPSEARRTYKRLLQRPARLMDRR DCTPCGSDLCCEEGYDCGTSTHHSNHGEPACIRHSAAKKDIDVEQRSITPFMASLRV K_0010_117 MHTLEMMLLILLLLPLAPGEGDGRAVRGDRNPNDASRTYKRLLQRPARRMDRR TCEPCAPNLCCEDGYRCGTSTNHQHYGEPACLSY----------------------- caracteristicusAHB89645 MHTLEMLLLVLLLVPLAPGEGDGQAVGGDRNPSEARRAYKRLLQRPARRMDRG GCTPCGPNLCCSEEFRCGTSTHHQTYGEPACLSY----------------------- quercinusAHB89644 -HTLEMLLLLLLLLPLAPGEGDGQAVAGDRNPSEARSTYKRFLQRPARRIDRR DCTPCGPNLCCEPGKTCGTSTHHDHYGEPACV------------------------- betulinusAMP44682 MHTLEMILLILLLLPLATGEGDGRAVGGDRSPSEAHRTYKRLLQRPARPVDRR ECTPCGPGLCCSPGETCGTSTHHDHYGEPACLSY----------------------- ermineusAXL95368 MHTLDMMLLILLLLPLATGEGDGRAVGGDRNPSETRRTYKRRLQRPARRMVRS DCTPCGPNLCCRPGLRCGTSTLHLTFDEPACLNH----------------------- flavidusAHB89647 MHTLEMLLLLLLLLPLAPGEGDGQAVAGDRNPGEARSTHKRFLQRPARRIHRH RCTPCGPDLCCEPGTTCDTVLHHTHFGEPSC-SY----------------------- [Superfamily Q-1b] [Framework XVI] [ /--------Signal-----/-------------Pro---------------/ /C--C----CC--------------] A_0875_247 -------------------------VGGDRIPSEARRTYKRLLERPARRMDRR DCVACGHDVCCYPLIRMWNLDAPRDF A_0875_071 MHTLEMMLLILLLLPLAPGEGAGRAVGGDRSPSEARRTYKRLLERPARRMDRR DCVACGHDVCC--------------- A_0885_094 MHTLEMMLLILLLLPLAPGEGAGRAVGGDRSPSEARRTYKRLLERPARRMDRR DCVACGHDVCCYPLIRMWNLDAPRDF A_0039_080 MHTLEMMLLILLLLPLAPGEGAGRAVGGDRSPSEARRTYKRLLERPARRMDRR DCVACGHNVCCHLLIRMWNLDAPRDF A_0055_070 MHTLEMMLLILLLLPLAPGEGAGRAVGGDRSPSEARRTYKRLLQRPARRMDRR DCVACGHNVCCHLLIRMWNLDAPRDF A_0520_315 MHTLEMMLLILLLLPLAPGEGAGRAVGGDRSPSEARRTYKRLLERPARRMDRR DCVACGHNVCCYPLIRMWNLDAPQDF A_0239_060 MHTLEMMLLILLLLPLAPGEGAGRAVGGDRSPSEARRTYKRLLERPARRMDRR DCVACGHNVCCHLLIRMWNLDAPRDF A_0031_132 MHTLKMMLLILLLLPLAPGEGAGRAVGGDRSPSEARRTYKRLLERPARRMDRR DCVACGHNVCCHLLIRMWNLDAPRDF A_0048_150 MHTLEMMLLILLLLPLAPGEGAGRAVGGDRSPSEARRTYKRFLERPARRMDRR DCKACGHDVCCYPLIMMWNLHAPRDF ermineusAXL95701 MHTLEMMLLILLLLPLAPGEGAGRAVGGDRSPSEARRTYKRLLERPARRMDRR DCVACGHDVCC--------------- [Superfamily Q-2] [Divergent_MSTLGMTLL-Superfamily] [Framework XIX] [ /----Signal-------/-------------Pro-------------/ /C-----C----C-------CCC-----C---------C---C------C-] A_0885_043 MSTLGTLLLIALLLPLANPADAGDGQAKPRSRNLRSLDFWLTLGRLTKI SCDPTEGCRATVCNTATG-PCCCPSGYYCKATLRHGRACVQG---------- A_0875_016 MSTLGTLLLIALLLPLANPADAGDGQAKPRSRNLRSLDFWHTLGQLDKI SCDPTEGCQTTVCNTKTG-PCCCPSGFSCKDTFRHGQACVQG---------- A_0239_412 MSTLGTLLLIALLLPLANPADAGDGQAKPRSRNLRSLDFGRTLGRLDKR SCDPTEGCQTTVC--------------------------------------- A_0055_069 MSTLGTLLLIALLLPLANPADAGDGQAKPRSRNLRSLDFGRTLGRFDKR SCDPTEGCQTTVCNTDTG-PCCCQSGFNCQPT-TFGRACVLVCE---HNC-- A_0048_245 MSTLGTLLLIALLLPLANPADAGDGQAKPRSRNLRSLDFRRTLGRLDER SCDPIEDCQTTVCGKE---PCCCPSGYNCQDTFRHGPACVKGCD---HNC-- K_0010_429 MSTLGMLLLIALLLPLANPADTGDGQAKPRTRNLRSLDFGHIPRQLDKR NCGSTENCSTPMCIPNGGVPCCCKPDEICEDSPRFGPVCSYSCD---HNCPK distansP0C8W0 MSTLGILLPIALLLPLANPAENGDGQAMPRTRNLRSLSFGRTLRRLEKR GCDPTDGCQTTVCETDTG-PCCCKPNFTCQISNSGTKSCS--CSGQPSDCPV [Superfamily Q-3] [New Framework] [ /-------Signal--------/----------Pro-------/ /C------C-----CC--CC----C-C-------------C-C-] V_1278_044 MS-TLGMM-LILLLLLPLAAFADDGPTIRGHSSDELLKS-NRD MCDIGDRTCGT-RWCCDECCQSSSCWCESNG-----IFQECVCPT A_0039_082 ---------LILLLLLPLAAFADDGPTIRGHSSDELLKS-NRD MCDIGDRTCGT-KWCCDECCESSSC-------------------- A_0055_110 MS-TLGMM-LILLLLLPLAAFADDGPTIRGHSSDELLKS-NRD MCDIGNRRCDT-LWCCDACCESSSCWCESNG-----YLQICVCPG A_0855_149 -----------LLLLLPLAAFADDGPTIRGHSSDGLLKSINRR ECDIGDRTCGT-KWCCDECCESSSCWCKSNG-----LFQECVCPT A_0239_061 MSTTLGMM-LILLLLLPLAAFADDGPTIRGHSSDGLLKSINRR ECDIGGRTCGT-KWCCDECCESSSCWCESNG-----ILQVCVCPT A_0031_256 ---------LILLLLLPLAAFADDGPTIRGHSSDELLKS-NRD MCDIGDRTCDT-KWCCDECCKSSSC-------------------- V_CG13_081 -----------LLLLLPLAAFADDGPTIRGHSSDGLLKSINRR ECEQGGRKCDSGRWCCDNCCDRSDCGCKEKESFG-IRFQECDC-- V_1302_128 MS-TLGMM-LLILLLLPLAAFADDGPTIRGHSSDGLLKSINRR ECEQGGR-CNSGKWCCDECCDRSDCQCKETIKHG-IRFQECDC-- V_1258_084 MS-TLGMM-LLILLLLPLAAFADDGPTIRGYSSDGLLKSINRR ECEQGGR-CNSGKWCCDNCCDRSDCQCKETMKHG-IRFQECDC-- V_1302_129 MS-TLGMM-LLILLLLPLAAFADDGPTIRGHSSDGLLKSINRR ECEQGGRICDSGNWCCDDCCDSSDCECKETVKYG-IRFEECDC-- V_1258_085 MS-TLGMM-LILLLLLPLAAFADDGPTIRGYSSDGLLKSINRR ECEQGGRICDSGNWCCDDCCDSSDCECKETIKYG-IRFEECDC-- A_0039_081 -------------------AFADDGPTIRGHSSDGLLKSINRR ESDQAGRECASGKWCLSDCCKNSNCGCKWEYVED-NRFRVCDC-- betulinusAMP44702 MS-ALGTM-LLILLLLPLAAFDGDGPTIRGHSSNKLWRSINRR ECDQ-NRECESGKWCCDQCCARSNCECRSEDVGGGVNIRVCDC-- praecellensATF27661 MS-TLRMMLLILLLLLPMAAFADDRPTIRGQRSAKFLKSITKR ECDQG-RPCTSGKWCCDDCCKRSNCGCRWEILDG-IRYRVCDC-- [Superfamily Q-4] [Framework XV] [ /-------Signal--------/----------------Pro--------------/ /-C----C---CC----C-C------------C-C] V_CG13_043 ---AMKMTLLTALLLLPLAALESDGPVMQRDADPKAVGSFLARVVRGNKKPGRLDAR SSCQTMVCGVACCPTTNCRCKLVGAQHFRKSVCVC V_1258_138 MMTAMKMTLLTALLLLPLAALESDGPVMQRDADPKAVGSFLARVVRGNKKPGRLDAR SLCKTMVCGVACCPTTNCRCKLVGAQHFRQSVCVC [Superfamily S-1a] [Framework VIII] [ /-------Signal------/---------Pro----------/ /---C---C-------C---C-C-----C-C------------C-C-C---] A_0025_404 -----------------------EGDVQARKAHLKSVFRRTLPR SGLTCTGGC--FESTECDGDCNCQGYDSCSCSAAGPHDNKNPGCSCYCQS-S ermineusAXL95485 MMSKMGAM-FVLLLLFTLASSQQEGDVQARKTHLKNVFRRTLPR SGLTCTGGC--FESTECDGDCNCQGYDSCSCSAAGPHDNKNPGCSCYCQS-S- A_0025_403 MMSKMGAM-FVLLLLFTLASSQQEGDVQARKTHLKSNFYRTLPR NVMVCTGTC--SQSSGCDGTCNCTHSTNCYCKRKA---RPSPGCWCICEM-- ermineusAXL95481 MMSKMGAM-FVLLLLFTLASSQQEGDVQARKTHLKSNFYRTLPR NVMVCTGTC--SQSSGCDGTCNCTHSTNCYCKRKA---RPSPGCWCICEM-- textileAGK23266 MMLKMGAM-FVLLLLFTLASSQQEGDIQARKTHLKSGFYRTLPR FARGCTISC-GYEDNRCQGECHCPGKTNCYCT-SG---HHNKGCGCAC---- gloriamarisGFNK01000072.1 -MSKMGAM-FLLLLLFTLASSQWEEDVQARKTHLKSDFYRTLPR FARGCTISC-GYENNRCQGECHCPGKTNCYCT-SG---HHNKGCGCAC---- episcopatusBAS22843 MMSKLGAM-FVLLLLFTLASSQEKGDVQAGKTQ-KSDFYRTLTR SARVCTMSC-AFQNNICQGTCHCSGSTNCYCA-SG---HHNTGCGCACTN-- A_1387_355 ------------------------GDAQTRKIRMKNVFLRTVKK SSE-CSGSCFGSKNSGCNGNCECP-GT-CWCS------SYRGECMCTCQG-- praecelensATF27763.1 MMWKMGAM-FVLLLLFTLPFGQQEGDVQARKMRSKNVFHRTMAK TTKRCEGTCFGSEQTNCNGSCECSSGGECYCG------YYRGSCMCTCTG-- andremeneziATF27523.1 -MWKMGAM-FVLLLLFTLTSSQQEGDVQARKMRSKNVFHRTMAK TTRGCEGTCYGSEETNCNGSCECSSGGECYCG------YYRGSCICTCAG-- betulinusAMP44696 MMWKMGVMLFVVFLLFPLASLQQEGDIQAKKIDLKSNFYGALER PARDCRGTC--GHTDQCTGTCECDGYDSCTCS-NS---GQHSGCTCSC---- caracteristicusB0L0Y5 MMLKMGAM-FVLLLLFILPSSQQEGDVQARKTHLKRGFYGTLAM STRGCSGTCHRREDGKCRGTCDCSGYSYCRCGDAH---HFYRGCTCTC---- betulinusAMP44747 MMSKMGVT-FVLLLLFTLASSQQDGDAQARKTHLKSDFYRTLAM STRACTGTC--GQGVGCRGTCNCQGNAQCWCGTNG---HFQTGCSCTCAG-- geographusBAO65639 MMSKMGAM-FVLLLLFTLASSQQEGDVQARKTRPKSDFYRALPR SGSTCT--C--FTSTNCQGSCECLSPPGCYCSNNG---IRQPGCSCTCPGTG striatusAGK23216 MMLKMGAM-FVLLLLFTLASVQQE-DVQARKTRLKRDFHRALRQ SPLGCPGTC--GKGGKCVGSCECTMYKNCYCSNNG---IRQPGCSCTCPTR- magusQFQ61097 MMSKMGAM-FVLLLLFTLVSVQQEGDVQARKTRLKRDFYRSLAI ---GCTGTC--YQSSRCDGKCDCDHSKNCYCSGKG---HHHPGCTCTCQMK- [Superfamily S-1b] [Framework VIII] [ /------Signal------/-----------Pro-----------/ /-C---C-------C---C-C-----C-C---------------C-C-C----] A_0039_100 MMSRMGVVFFLLLLFALASTQQEGDVEAKKVDNWSYRNVFLSRAAR GRC--TC--G-GNQCNGSCECRGK-NCHCK-RG---SGRSAGSACHCSCWS--- A_0855_054 MMSRMGVVFFLLLLFALASTQQEGDVEAKKVDNWSYRNVFLSRAAR GTC--TC--G-GNQCNGSCECRGH-NCHCK-RG---SGRSVGSACHCSCWS--- A_0055_082 --------FFLLLLFALASTQQEGDVEAKKVDNWSYRNVFLSRAAR RTC--TC--G-GNPCSGSCKCRGH-TCHCK-RG---SGRSAGSACHCSCWI--- A_0855_055 MMSRMGVVFFLLLLFALASTQQEGDVEAKKVDNWSYRNVFLSRAAR GMC--TC--GRSHQCNGSCACRGE-NCRCE-RG---SRRS-GSVCHCSCPSYLM A_0885_112 --------------FALASTQQEGDVEAKKVDNWSYRNVFLSRAAR EMC--TC--GRNHQCNGSCDCRGE-NCRCE-RG---SGRSVGSACHCSC----- A_0875_029 MMSRMGVVFFLLLLFALASTQQEGDVEAKKVDNWSYRNVFLSRAAR GMC--TC--GRSHQCNGSCACRGE-NCRCE-SG---SRRSGSVCHCSCPS---- V_CG13_024 MMSRMGVVFFLLLLFALASTQQEGDVEARKVDDWSYRNVFLSRAGR --C--TC--GSSDQCNGSCACRGD-DCSCR-KG---NAGPSGSVCYCSCPT--- V_1258_011 MMSRMGVVFFLLLLFTLASTQQEGDVEARKVDDWSYRNVFLSRAGR G-C--TC--GSSDQC--------------------------------------- V_1302_211 MMSRMGVVFFLLLLFTLASTQQEGDVEARKVDDWSYRNVFLSRAGR G-C--TC--GSSDQCNGSCACRG------------------------------- A_0239_278 MMSRMGVVFFLLLLFALASTQQEGDVEAKKVDNWSYRNVFLSRAAS GMC--TC--GRSHQCSGSCACRGE-NCRCE-RG---SRRS-GSVCHCSCPS--- A_0031_119 MMSRMGVVFFLLLLFALASTQQEGDVEAKKVDNWSYRNVFLSRAAS GMC--TC--GRRHQCNGSCACRGE-NCRCE-RG---SRRS-GSVCHCSCLS--- A_1387_093 MMSRMGVVFFLLLLFALASTQQEGDVEAKKVDNWSYRNVFLSRAGG GMC--TC--GRSHQCNGSCACRGE-NCHCK-RG---NGRSAGSVCHCSCPS--- ermineusAXL95499 MMSRMGVVFFLLLLFALASTQQEGDVEARKIDNWSYRHVLLSRRGQ Q-C--TC--GSTDQCDGSCACRGN-NCRCK-RG---FHRA-ASKCHCSCQN--- [Superfamily T-1] [Framework V] [ /--------------Signal----------------/-------------Pro-------------/ /CC------CC-/Pos-] V_CG13_005 -MHCLPVFVILLLLIAS--APS-------------VDAQPKTKYDVPLASRHDNAQSALQ-IH-WNKR -CCPRKL-WCCFPW---- V_1302_115 -MHCLPVFVILLLLIAS--APS-------------VDAQPKTKYDVPLASRHDNAQSALQ-IH-WNKR -CCPRKL-WCCFL----- A_0885_054 -MHCLPVFVILLLLIAS--APG-------------VDAQPKTNYDVPLASRHDNAPSALQ-IH-WNKR -CCPTNP-WCCVGIGK-- A_0055_088 -MRCLPVFVILLLLIAS--APG-------------VDAQPKTNYDVPLASRHDNAQSALQ-IH-RKSS -CC-THL-WCCIGIGK-- A_0885_053 -MHCLPVFVILLLLIAS--APG-------------VDAQPKTNYDVPLASRHDNAQSALQ-IH-RKSS -CCKKDP-WCCVGIGK-- A_1387_312 -MRCLPVFVILLLLIAS--APG-------------VDAQPKTNYDVPLASRHDNAQSAPQ-IH-WKKG -CCPQSR-WCCTGVGK-- A_0520_268 -MHCLPVFVILLLLIAS--APG-------------VDAQPKTNYDAPLASRHDNAQSAPQ-IH-WKKG -CCPQSR-WCCTGVGK-- A_0039_030 -MRCLPVFVILLLLIAS--APG-------------VDAQPKTNYDVRLASRHDNAQSALQ-IH-RRNR -CCQENP-VCCTGAGK-- A_0048_195 -MRCLPVFVILLLLIAS--APG-------------VDAQPKTNYDVPLASRHDNAQSALQ-IH-WNKR -CCPEIL-LCCRLIGAVN A_0055_089 -MRCLPVFVILLLLIAS--APG-------------VDAQPKTNYDVPLASRHDNAQSALQ-IH-RNKR -CCPKSP-SCCIWQW--- A_0239_006 -MRCLPVFVILLLLIAS--APG-------------VDAQPKTNNDVPLASRHDNAQSALQ-IH-RNKR -CCPKSP-SCCIWQW--- A_0031_081 -MRCLPVFVILLLLIAS--APG-------------VDAQPKTNYHVRLASRHDNAQSALQ-IH-RKNS -CCQKNP-VCCAGLGK-- ermineusAXL95476 -MRCLPVFVILLLLIPS--APS-------------VDAHPKTKDDMPLASFHDNAKRTLQ-RF-WKKR DCCPEKM-WCCPLG---- caracteristicusP0C668 -MRCVPVFIILLLLIAS--APG-------------VDAQPKTKYNAPLTSLHDNAKGILQ-EH-WNKR -CCPRRL-ACCIIGRK-- episcopatusBAS23531 -MRCLPVFVILLLLIAS--APS-------------VDALPKTKDDVSLASFHDNAKRTLQ-IL-SNKR YCCVYDY-SCCLSWG--- leopardusAAT01633 -MRCVPVFIILLLLIPS--APS-------------VDAQRKTKDDVPLASFHDNAKRTLK-RL-WNKR SCCPQEF-LCCLYLVK-- litteratusABC70187 -MRCLPVFIILLLLIPS--APS-------------VDAQRKTKDDVPLASFHDNAKRTLK-RL-WNKR SCCPQEF-LCCLYLVK-- praecelensATF27793.1 -MRCLPVFVILLLLIPS--APN-------------VHARPKTKDDVPLASIHDNAERTLL-RQ-WNKR TCCQFYP-SCCPTRK--- andremeneziATF27529.1 -MCCLPVFIILLLLIPS--APN-------------VHARPKTKDDVPLASFHDNAERTLL-RQ-WNKR TCCQFYP-SCCPTRK--- ventricosusQ9BPG5 -MRCLPVFVILLLLIAS--APG-------------VDAQPKTKYDVPLASRHDFAKKTPK-RL-SKPR DCCRRNF-LCC------- gloriamarisGFNK01000076 -MRCLPVFVILLLLIAS--APS-------------VDAQPKTKDDVPLAPLHDNIRSTLQ-TL-RKKV -CCRPVQ-DCCSGK---- gloriamarisGFNK01000090 ---------ILLLLIAS--APS-------------VDAQPKTKDDVPLASLHDNIKSTLQ-TL-WNKR -CCPPVI-WCCG------ magusQFQ61110 -MRCLPVLIILLLLIPS--APS-------------VDAQPMTKDDVPLASLHDNAKRALQ-MF-WNKR-DCCPAKL-LCCNP----- A_0039_072 -MRCLPVFIILLVLSAS--APS-------------VDARPKNEDDVSQASFHDNSQRTLQ-RL-LNKR SCCPESP-PCCH------ A_0875_130 -MRCLPVFIILLVLSAS--APS-------------VDARPKNEDDVSQASFHDNAQRTLQ-RL-LNKR SCCPGSP-PC-------- V_1302_113 -MRCLPVFVILLLLIAS--APS-------------VDARPKNEDDVSLASFHDNAQRTLQ-RL-LNKR SCCPGSP-PCCH------ A_1387_315 -MRCLPVFIILLVLSAS--APS-------------VDARPKNEDDVSLASFHDNAQRTLQ-RL-LNKR SCCPESP-PCCH------ A_0048_193 -MRCLPVFIILLVLSAS--APS-------------VDARPKNEDDVSLASFHDNAQRTLQ-RL-LNKR PCCPEFP-PCCH------ A_0025_388 -MRCLPVFIILLVLSAS--APS-------------VDARPKNEDDVSLASFHDNAQRTLQ-RL-LNKR ACCPESA-ACCHLPA--- K_0010_029 -MRCLPVFVILLLLIAS--APS-------------VDAQPKTKDDVSLTSFHDNAKRPLQ-RL-RNKR WCCPEKR-WCCNPW---- ermineusAXL95463 -MRCLPVFIILLVLSAS--APS-------------VDARPKNEDDVSLASFHDNAQRTLQ-RL-LNKR ACCPESA-ACCHLPA--- ventricosusQ9BPF2 -MRCLPVFIILLVLSAS--APS-------------VDARPKNEDDVSLASFHDNAQRTLQ-RL-LNKR SCCPNNP-ACCH------ betulinusAMP44630 -MRCLPVFIILLVLIAS--APT-------------VDARPKIEDDESLASFHDNVKQTLQ-RL-LNKR DCCPESP-PCCH------ V_CG13_004 -MHCLPVFVILLLLIAS--APS-------------VDARPKTKDDVPLASFHGNAERTLLNIL-RADG TCCIDKQ-GCCPWG---- V_1302_114 -MRCLPVFVILLLLIAS--APS-------------VD---------------GNAERTLLNIL-RADG TCCIDKQ-GCCPWG---- V_1302_192 -----PVFVILLLLIAS--APS-------------VDARPKTKDDVPLASFHGNAERTLLNIL-RADG TCCIDKQ-GCCKLC---- V_1302_193 -----PVFVILLLLIAS--APS-------------VDARPKTKDDVPLASFHGNAERTLLNIL-RADG TCCIDKQ-GCCPWG---- V_1258_146 -MRCLPVFVILLLLIAS--APS-------------VDARPKTKDDVPLASFHGNAERTLLNIL-RADG TCCMDTQ-GCCPWG---- V_1258_147 -MRCLPVFVILLLLIAS--APS-------------VD---------------GNAERTLLNIL-RADG TCCMDTQ-GCCPWG---- A_0055_166 -MRCLPVFVILLLLIAS--APS-------------VDTQQKTKDDVPLASFHGNAERTLRYIL-RDAE NCCKEKK-GCCPWG---- A_0039_071 -MRCLPVFVILLLLIAS--APS-------------VDTQQKTKDDVPLASFHGNAERTLRYIL-RDAE NCCKEKK-GCCPWG---- A_0239_424 -MRCLPVFVILLLLIAS--APS-------------VDTQQKTKDDVPLASFHGNAERTLRYIL-RDAE NCCKEKK-GCCPWG---- A_0031_303 -MRCLPVFVILLLLIAS--APS-------------VDTQQKTKDDVPLASFHGNAERTLRYIL-RDAE NCCKEKK-GCCPWG---- ventricosusQ9BPF7 -MRCLPVFVILLLLIAS--APS-------------VDARPKTKDDVPLASFHGNAERTLLNIL-RDGD NCCIDKQ-GCCPWG---- episcopatusBAS23587 -MRCLPVFVILLLLIAS--APS-------------VDARPKTKDDIPQASFQDNAKRILLMDI-R--- ECCMGTP-GCCPWG---- pulicariusP0C639 -MRCVPVFVILLLLIAS--TPS-------------VDATQKTKDDMSLASFHDNAKRFL-QTL-RNTR SCCPEEI-TCCPWG---- A_0855_109 -MHCLPVFVILLLLIAS--APS-------------VDVQPKTKNFMTRASLRDFAKKTPK-RL-SKPR GCCPRNI-LCC------- V_1302_112 -VHCLPVFVILLLLIAS--APG-------------VDVQPKTKNFMTRASLRDFAKKTPK-RL-SKLR DCCPQSF-LCCDFSKETK V_1302_116 -MRCLPVFVILLLLIAS--APG-------------VDVQPKTKNFMTRASLRDFAKKTPK-RL-SKLR DCCPQSF-LCCDFSKETK V_1278_020 -MRCLPVFVILLLLIAS--APS-------------VDVQPKTKNFMTRASLRDFAKKTPK-RL-SKLR DCCLRNF-LCCDFSEETK V_1278_021 -MRCLPVFVILLLLIAS--APS-------------VD---------------DFAKKTPK-RL-SKLR DCCLRNF-LCCDFSEETK A_0885_050 -MHCLPVFVILLLLIAS--APS-------------VDVQPKTKNFMTRASLRDFANKTPK-RL-SKPR DCCPRWF-ICYFG----- A_0885_051 -MHCLPVFVILLLLIAS--APS-------------VDVQPKTKNFMTRASLRDFAKKAPK-RL-SKPR DCCQRNI-LCCE------ A_0885_052 -MHCLPVFVILLLLIAS--APS-------------VDVQPKTKNFMTRASLRDFANKTPK-RL-SKPR DCCPSLF-ICCG------ A_0039_073 -MHCLPVFVILLLLIAS--APS-------------VDVQPKTKNFMTRASLRDFANKTPK-RL-SKQR DCCPSLF-ICCG------ A_0875_129 -MHCLPVFVILLLLIAS--APS-------------VDVQPKTKNFMTRASLRDFANKTPK-RL-SKPR DCCPSLF-ICCG------ A_0055_165 -MRCLPVFVILLLLIAS--APS-------------VDVQPKTKNFMTRASLRDFAKKTPK-RL-SKPR DCCPRSF-LCCETK---- A_1387_311 -MYCLPVFVILLLLIAS--APS-------------VDVQPKTKNFMTRASLRDFAKKAPK-RL-SKPR DCCQRNF-LCCG------ A_1387_313 -MHCLPVFVILLLLIAS--APS-------------VDVQPKTKNFMTRASLRDFAKKAPK-RL-SKPR DCCQRNF-LCCG------ A_0855_108 -MHCLPVFVILLLLIAS--APS-------------VDVQPKTKNFMTRASLRDFAKKTPK-RL-SKPR DCCQRNF-LCC------- A_0520_267 -MHCLPVFVILLLLIAS--APS-------------VDVQPKTKNFMTRASLRDFAKKTPK-RL-SKPR DCCQRNF-LCC------- A_0048_194 -MHCLPVFVILLLLIAS--APS-------------VDVQPKTKNFMTRASLRDFAKKTPK-RL-SKPR DCCQRNF-LCC------- A_0239_309 -MHCLPVFVILLLLIAS--APS-------------VDVQPKTKNFMTRASLRDFAKKTPK-RL-SKPR DCCQRSF-LCCR------ A_0031_302 -MHCLPVFVILLLLIAS--APS-------------VDVQPKTKNFMTRASLRDFAKKTPK-RL-SKPR DCCKRNF-LCCK------ A_0031_300 -MHCLPVFVILLLLIAS--APS-------------VD---------------DFAKKTPK-RL-SKPR DCCKRNF-LCCK------ A_0025_379 -MHCLPVFVILLLLIAS--APS-------------VD---------------DFAKKTPK-RL-SKPR GCCLRNF-MCCE------ A_0025_378 -MHCLPVFVILLLLIAS--APS-------------VDVQPKTKNFMTRASLRDFAKKTPK-RL-SKPR GCCLRNF-MCCE------ ventricosusQ9BPG1 -MHCLPVFVILLLLIAS--APG-------------VDVQPKTKNFMTRASLRDFAKKTPK-RL-SKLR GCCPRSF-LCCR------ ermineusAXL95505 -MRCLPVFIILLLLIAS--APS-------------VDVQRKTRNSMTRASLRNFEKKSIE-VL-KEKG PCCFSNP-YCCNLR---- emaciatusAGK23258 -MLCLPVFITLLLLISS--APS-------------VDAQTKTKNFLTLASLRDFAKKSPK-RL-T-QF ECCSEVF-SCCR------ betulinusAMP44628 -MRCLPVFIILLLLVAS--APS-------------ADVQPKTKNSMTLASLRDFAKKGRK-NL-WRRS ECCIRNF-LCC------- andremeneziATF27537 -MRCLPVFIILLLLIPS--APG-------------VDVQPKTKNSVTLTSLRNFPEKTLK-RL-QSQT QCCIQRR-SCCDD----- A_0855_071 MMRCFPVVIIFLLLLSSATAPA-------------VGS----KRLRKFTSFRDFGKTIQK-SL-RKTP ECCLSRL-PCCLALV--- A_0520_199 MMRCFPVVIIFLLLLLSATAPA-------------VGS----KRLRKFTSFRDFGKTIQK-SL-RKTP ECCLSRL-PCCLALV--- A_0025_038 MMRCFPVVIIFLLLLSSATAPA-------------VGS----KRLRKFTSFRDFGKTIQK-SL-RKTP ECCLSRL-PCCLALV--- V_1302_043 MMRGFPVVIIFLLLLSSATAPA-------------VGS----KRLRKFTSFRDFGKTIQK-SL-RKTK ECCLSRH-PCCLALV--- A_0520_198 MMRCFPVVIIFLLLLLSATAPA-------------VGS----KRLRKFTSFRDFGKTIQK-SL-RMDP YCCVSRH-PCCLALV--- A_0031_025 MMRCFPVVIIFLLLLSSATAPA-------------VGS----KRLRKFTSFRDFGKTIQK-SL-RMDQ YCCLSRH-PCCLALV--- A_0885_153 MMRCFPVVIIFLLLLSSATAPA-------------VGS----KRLRKFTSFRDFGKTIQK-SL-RMNP YCCLARN-PCCLALV--- V_1258_036 MMRCFPVVIIFLLLLSSATAPA-------------VGS----KRLRKFTSFRDFGKTIQK-GL-RKTK ECCLSRQ-PCCLALV--- V_CG13_080 MMRCFPVVIIFLLLLSSATAPAVGSKRLRKFTSFRVGS----KRLRKFTSFRDFGKTIQK-GL-RKTK ECCLSRQ-PCCLVPV--- A_0055_007 MMRCFPVVIIFLLLLSSDAAPA-------------VGS----KRLRKFTSFRDFGKTIQK-SL-RQNT ICCFSRR-LCCQALV--- ermineusAXL95369 MTRGLPVVIIFLLLLSSSTAPV-------------DGS--KTKRLRGFTSFRDAGKTIQK-SL-RADR -CCLSRH-PCCQLPA--- andremeneziATF27549 MMRCLPVVILLLLLLPSPTAPA-------------VGP--KTKRLRGLTSFRDFGKATQK-GLRTDQM ECCNERL-PCCKNLH--- [Superfamily T-2] [Framework V] [ /------Signal-----/-------------------Pro-------------------------/ /-CC------CC/----------------] A_0885_101 MLHLPILIIVLLVLSHAAGVP------------------ELQRDLTQESPKDFGMRSEHL----LLR IRCCSPNDISCCYVPFG------------- A_0039_119 MLRLPILIIVLLVLSPAAGVP------------------ELQRDLTQESPKDFGMRSEHL----LLR KLCCSPDDISCCYVPFG------------- A_0239_362 MLHLPIFIILLLVLSPAACFPVESELQRDLTQESPKVESELQRDLTQESPKDFGMKTEHL----LLR DECCMPGNQGCCQ----------------- A_0025_256 MLHLPILIILLLVLSPAACFPVESELQRDLTQESPKVESELQRDLTQESPKDFGMKTEHL----LLR DKCCMHSNKSCCYK---------------- V_CG13_190 MLHLPIFIILLLVLSPAACFP---------------VESELQRDLTRQSPKDFGMRTAHL----LLR DYCCMYGNKSCCYR---------------- V_1302_094 MLHLPIFIILLLVLSPAACFP---------------VESELQRDLTRQSPKDFGMRTAHL----LLR DYCCMYGNKSCCYR---------------- V_1258_082 MLHLPIFIILLLVLSPAACFP---------------VESELQRDLTRQSPKDFGMRTAHL----LLR DYCCMYGNKSCCYR---------------- A_0055_372 ----PIFIILLLVLSPAACFP---------------VESELQRDLTQESPKDFGMRSEHL----LLR SHCCSPNDRSCCYFPFR------------- A_0855_101 MLHLPIFIILLLVLSPAAGLP---------------VESEQQRDLTRQSPKDFGMGTARL----LLR EHCCNLDKG-CCKL---------------- A_0855_102 MLHLPIFIILLLVLSPAAGLP---------------VESEQQRDLTRQSPKDFGMGTARL----LLR EHCCNLDKG-CCYV---------------- A_0885_151 MLHLPIFIILLLVLSPAAGLP---------------VESEQQRDLTRQSPKDFGMGTARL----LLR EHCCMLDNG-CCSG---------------- A_0520_295 MLHLPIFIILLLVLSPAAGLP---------------VESEQQRDLTRQSPKDFGMRTARL----LLS EHCCMLDDG-CCSG---------------- A_0048_140 MLHLPIFIILLLVLSPAAGLP---------------VESEQQRDLTRESPKDFGMRTARL----LLR EHCCMLDDG-CCSG---------------- A_0048_141 MLHLPTLIIVLLVLSPAAGLP---------------VESEQQRDLTRESPKDFGMRTARL----LLR EHCCMLDDG-CCSG---------------- ermineusAXL95734 MLHLPSFIILLQVLSPADGLP---------------VESEQQRDLTRQSPKDFGMRTARL----LLR EHCCMLDDG-CCSG---------------- A_0855_074 MFCLPVFIILLLLVSPAATLP---------------VESELERDLTQESPKDFGMRTEHF-PL-MTR IYCCPGYE--CCTD---------------- A_0031_343 MLCLPVFIILLLLVSPAATLP---------------VESELERDLTQESPKDFGMRTEHF-PL-MTR IYCCPGYE--CCVP---------------- A_0875_098 MFCLPVFIILLLLVSPAATLP---------------VESELERDLTQESPKDFGMRTKHF-PL-MTR IYCCPGYE--CCVPDSD------------- A_0039_116 MFCLPVFIILLLLVSPAATLP---------------VESELERDLTQESPKDFGMRTEHF-PL-MTR IYCCPGYE--CCVPDSD------------- A_0039_115 MFCLPVFIILLLLVSPAATLP---------------VESELERDLTQESPKDFGMRTEHF-PL-MTR IYCCPGYE--CCVPDSGK------------ A_0875_096 MFCLPVFIILLLLVSPAATLP---------------VESELERDLTQESPKDFGMRTKYF-PP-MTW IYCCPGYE--CCTD---------------- A_0055_183 ----PIFIILLLVLSPAACFP---------------VESELQRDLTQESPKDFGMRTEHF-PL-MTW IDCCPVYD--CCVPDSD------------- A_0885_100 MFCLPVFIILLLLVSPAATLP---------------VESELERDLTQESPKDFGMRTEHF-PL-MIW VDCCPVYD--CCVPDSD------------- A_0031_341 MLCLPVFIILLLLVSPAATLP---------------VESELERDLTQESPKDFGMRTEHF-PL-RTW LDCCPVYD--CCVADSD------------- A_0031_342 MLCLPVFIILLLLVSPAATLP---------------VESELERDLTQESPKDFGMRTEHF-PL-RTW LDCCPVYD--CCVADSGVADSD-------- A_0855_073 MFCLPVFIILLLLVSPAATLP---------------VESELERDLTQESPKDFGMRTEHF-PL-KIW VDCCPAYD--CCVPDSD------------- A_0025_257 MFCLPVFIILLLLVSPAATLP---------------VESELERDLTQESPKDFGMRTEHF-PL-MIW VDCCPAYD--CCVPDSD------------- A_0520_173 MLCLPVFIILLLLVSPAATLP---------------VESELQRDLTQESPKAFGMRTEHL-PR-TVL SSCCIMNI--CC------------------ A_0055_184 MLCLPVFIILLLLVSPAATLP---------------VESELERDLTQESPKDFGMRTEHF-PL-MTW IDCCPAFE--CCVVRDPNYD---------- A_0055_185 MLCLPVFIILLLLVSPAATLP---------------VESELERDLTQESPKDFGMRTEHF-PL-MTW IDCCPAFE--CCVVRDPNYGK--------- K_0010_219 MLCLPVFIILLLLVSPAATLP---------------VESELQRDLTQESPKAFGMRTEHL-PR-TVL SSCCIMNI--CC------------------ ermineusAXL95511 ---LPVFIILLLLVSPAATLP---------------VESELERDLTQESPKDFGMRTEHF-PL-MIW VDCCPAYD--CCVPDSD------------- vexillumAGK23237 MLCLPVFIIHLLLVSPAATLA---------------VESELQRDLTHESPKDFGMRTEHL-PVKRVG DDCCVGNVGTCCS----------------- rattusAGK23245 MLCLPVFIILLLLVSPAATLP---------------VGSELQRDLTHESPKDLGMRTDYL-PFRDVG DDCCSDNVGTCCK----------------- andremeneziATF27561 MLCLPVFIILLLLVSPAATLP---------------VESELQRDLTQVSAEDFGMRTEYE--RRKQW GDCCNNGD--CCN----------------- praecellensATF27810 MLCLPVFIILLLLVSPAATLP---------------VESDLQRDLTQVSSKDFGMRTELKLKRRLQR PTCCGRGI--CCKWPKSSTV---------- betulinusAMP44631 MLCIPIFIILLLVLSPAASLP---------------VESELQRDLTQESPKDLGMN-EHLLLK-KVA DDCCNYGVSDCCIG---------------- V_CG13_191 -----------LVLSPAASFP---------------VESKLGRLWTRKLSRDLGEQHHTFD---RKR TLCCLTPGAPCCKT---------------- V_1302_215 ---------------PAASFP---------------VESKLGRLWTRKLSRDLGEQHHTFD---RKQ TLCCLTPGATCCSQVSR------------- V_1258_091 -----IFIILLLVLSPAAIFP---------------VESKLASLWNRMLSRDLGEQHHTFD---RKQ TLCCLTPGATCCSQVSR------------- V_1278_032 -----IFIILLLVLSPAAIFP---------------VESKLASLWNRMLSRDLGEQHHTFD---RKQ ILCCLTPGAPCCSRVSR------------- A_0055_143 MLSIPIFIILLLVLSPAAIFP---------------VESKLASLWPRMLSRGLGEQHHTFD---RKQ -LCCLSPGGTCCPPVSS------------- A_0239_356 MLRLPNFIILLLVLSPAAIFP---------------VESKLASLWPRMLSRGLGEQHHTFD---RKQ -LCCLSPGGTCCPPVSS------------- ermineusAXL95512 -----IFIILLLFLSPAAGFP---------------VESKLVSLGTRMLSRNLGEQHHTFD---RKQ TLCCLTPGSDCCGRDRYYSKALKNGQLRKK [Superfamily T-2 WF] [No Framework of T-2] V_1302_093 ---LPVFIILLLLVSPAATLP---------------VESELQRDLTQQSPKDLGMRTKHLPLKPWIDCIIFPDQCSIVVIPESGK---------- A_0239_361 MFCLPVFIILLLLVSPAATLP---------------VESELERDLTQKSPEGSGMRTKHLPLKFWVDCTQFPDQCVPDSD--------------- V_1302_096 ---LPIFIILLLVLSPAAGVP---------------VESELQRDLTQQSPKDLGMRMKHGP--GWIDCTSMQDDCKD--QGLKV----------- A_0875_111 MLRLPILIIVLLVLSPAAGVS---------------VESKLQRKLTRASSQDFGRETRVTTHSPPKD--YFDQIGDNLI---------------- A_0039_123 MLRLPILIIVLLVLSPAAGVS---------------VESKLQRKLTRASSQDFGRETRVTTHSPPKD--YFDQIGDNLI---------------- A_0855_154 MLRLPILIIVLLVLLPAAGVP---------------VESKLQRKLTRASSQDFGRETRVTTHSPPKD--YFDQIGDSLI---------------- A_0520_294 MLHLPIFIILLLVLSPAAGLP---------------VESKLQRKLTQSSSRDFGRETRAATPPPVNDQSSHLDPIDNDIM--------------- A_0520_296 MLHLPIFIILLLVLSPAAGLP---------------VESKLQRKLTQSSSRDFGRETRAATPPPVNDQSSHLDPIDNDII--------------- A_0239_363 MLHLPIFIILLLVLSPAAGVP---------------VESKLQRKLTQSSSRDFGRETRAATPPPVNDQSSHLDPIDDDIIGIKARKKIDSVVFSR A_0025_204 MLHIPIFIILLLVLSPAAGVP---------------VESKLQRKLTQSSSRDFGRETRAATPPPVNDQSSHLDPIDDDII--------------- A_0025_205 MLHIPIFIILLLVLSPAAGVP---------------VESKLQRKLTQSSSRDFGRETRAATPPPVNDQSSHLDPIDDDIM--------------- ermineusAXL95495 MLRLPIFLILLLVLSSAAGFP---------------AESELERDLTLESSKDFGMRSVPLPPFEVL-QNY--DEKDDSGR--------------- magusQFQ61117 MLRLPIFLIVLLVLSSAAGFP---------------VESKLQRDLTQESPKDFGMRAKHL----------------------------------- [Superfamily T-3] [Framework V] [ /-----Signal------/----Pro-----/ /-------------------------------CC-------CC-----] V_CG13_170 MLCLPVFIILLLLASPAAPNPVERRIQSDLIR AGLEDAGAKFEKGLLSAVVQNLDKIGGTATKVCCYFT--TSCCPDDDE- V_1258_144 MLCLPVFIILLLLASPAAPNPVETRIQSDLIR AGLEDAGAKFEKGLLSAVVQNLDKIGGTATKVCCYFT--TSCCPDDDE- V_1302_153 M-CLPVFIILLLLASPAAPNPVERRIQSDLIR AGLEDAGAKFEKGLLSAVVQNLDKIGGTATKVCCYFT--KTCCPGDDE- V_1258_145 MLCLPVFIILLLLASPAAPNPVETRIQSDLIR AGLEDAGAKFEKGLLSAVVQNLDKIGGTATKVCCYFT--KTCCPGDDE- V_1302_154 M-CLPVFIILLLLASPAAPNPVERRIQSDLIR AGLEDAGAKFEKGLLSAVVQNLDKIGGTATKVCCYFT--TSCCPDDDE- V_CG13_174 MLCLPVFIILLLLASPAAPNPVERRIQSDLIR AGLEDAGAKFEKGLLSAVVQNLDKIGGTATKVCCFFT--KSCCSDDDE- A_0875_094 MLCLPVFIVLLLLASLAAPNPLETRIQSDLIR AALEDADMKTEKGVLSGLFANLGPISELASTFCCALI--PKCCPE---- A_0025_393 MLCLPVFII-LLLASPAAPKPLETRIQSDLIR AALEDADMKTEKGVLSGLFANLGPISELASTFCCALI--PKCCPE---- A_0025_398 -------------------------------- AALEDADLKTKERFLSGILGNAGPISDLVSKFCCSVL--PICCVMT--- ermineusAXL95504 MLSLPVFIILLLLASAAAPNPLETRIQSDLIR AALEDADLKTKERFLSGILGNAGPISDLVSKFCCSVL--PICCVMT--- ermineusAXL95491 MLCLPVFIILLLLASPAAPNPLETRVQSDLIR AALEDADMKTEKGVLSGLFANLGPISELASTFCCALI--PKCCPE---- betulinusAMP44754 MLCLPVFIILLLLASPAAPNPLETRIQNDLIR AALEDTDMKIEKGFLSSLVGNLGNIGNMAAGVCCSFT--KSCCSEP--- arenatusQ9BHA6 MLCLPVFIILLLLASPAASNPLETRIQSDLIR AALEDADMKNEKNILSSIMGSLGTIGNVVGNVCCSIT--KSCCASEE-- tessulatusQ9BPE3 MLCLPVFIILLLLASPAAPNPLERRIQSDLIR TALEDADMKTPKGVLSGIMSNLGTVGNMVGGFCCTVY--SGCCSEK--- V_1278_084 MLCLPVFIILLLLASPAAPNPLETRIQSDLIR AGLEDADM----------------------------------------- V_1258_141 MLCLPVFIILLLLASPAAPNPVETRIQSDLIR AGLEDADMKTDDR--GDLSDLLNEGGSVVMQICCSAF--KTCCAEE--- V_1302_152 MCLPVFIILLLL-ASPAAPNPVETRIQSDLIR AGLEDADMKTDDR--GDLSDLLNEGGSVVMQICCSAF--KTCCKLS--- V_1278_083 MLCLPVFIILLLLASPAAPNPAETRIQSDLIR AGLEDADMKTDDW--GVVSDLLN----VFMQICCSAF--STCCKLS--- V_1278_082 ----PVFIILLLLASPAAPNPLETRIESDLIR AGLEDADMKTDDW--GVVSDLLN----VFMQICCSAF--STCCAEE--- V_1278_081 ----PVFIILLLLASPAAPNPAETRIQSDLIR AGLEDADMKTDDW--GVVSDLLN----VFMQICCSAF--STCCAEE--- ermineusAXL95619 MLCLPVFIILLLLVSAAAPNPLETRIQSDLIR AGLEDADMKTDDW--GVVSDLLN----VFMQICCSAF--STCCAEE--- A_0885_102 MLCLPVFIVLLLLASLAAPNPLETRIQSDLIR AALEDADMKTDEREETDIPSIIDAASDIAKQICCRIT--AECC------ A_0875_093 MLCLPVFIVLLLLASLAAPNPLETRIQSDLIR AALEDADMKTDEREETDIPSIIDAASDIAKQICCRIT--AECC------ A_0055_191 MLCLPVFIILLLLASLGAPNPVETRIQSDLIR AALEDADMKTDEREETDIPSIINAAADIAKQICCRIT--SECC------ A_0520_168 -------------------------------- ----DADMKTDEREETDIPSIINAAADIAKQICCRIT--SECC------ A_0520_169 MLCLPVFIVLLLLASLAAPNPLETRIQSDLIR AALEDADMKTDEREETDIPTIIDAAADIAKQICCRIT--SECC------ A_0048_298 MLCLPVFIILLLLASLAAPNPLETRIQSHLIR AALEDADMKTDEREETDIPSIINAAADIAKQICCRIT--SECC------ A_0048_295 MLCLPVFILLLLLASPAAPNPSETRIQSDLIR AALEDADMKTDEREETDIPSIINAAADIAKQICCRIT--SECC------ A_1387_324 MLCLPVFIILLLLASPAAPNPLETRIQSNLIR AALEDADMKTDEREGTDIIDIINAAADIAKQICCRIT--SESC------ A_0031_376 MLCLPVFIILLLLASPAAPNPLETRIQSDLIR AALEDADMKTDEREQSSIIDIINASSDIAKQICCQFS--SECC------ A_0855_144 --CLPVFIVLLLLASLAAPNPLETRIQSDLIR AALEDADMKTDEREETDIPSIIDATADIAKQICCRIT--SECCKLSEE- A_0855_145 --CLPVFIVLLLLASLAAPNPLETRIQSDLIR AALEDADMKTDEREETDIPSIIDAAADVAKQICCRIT--SECCKLSEE- A_0025_399 MLCLPVFIILLLLASLAAPNPLETRIQSDLIR AALEDAD----EREKTDIPSIIDAASDMAKQICCRIT--SECCPDDEK- A_0239_418 -----------------APNPVETRIQSDLIR AALEDAD----ERERTDIPSIIDAASDIAKQICCRIT--SECCPDDEK- A_0055_187 MLCLPVFIILLLLASLGAPNPVETRIQSDLIR AALEDAD----ERERTDIPSIIDAASDIAKQICCRIT--SECCPDDEK- A_0039_117 MLCLPVFIILLLLASLGAPNPVETRIQSDLIR AALEDAD----ERERTDIPSIIDAASDIAKQICCRIT--SECCPDDEK- A_0039_120 MLCLPVFIILLLLASPAAPNPLETRVQSDLIR AALEDADMKTDEREQSSIIDIINASSDIAKQICCQFS--SECCPDDEK- A_0039_122 MLCLPVFIILLLLASPAAPNPLETRVQSDLIR AALEDADMKTDEREQSSIIDIINASSDIAKQICCRIT--SECCPDDEK- A_0055_192 MLCLPVFIILLL-ASPAAPNPLETRIQSDLIR AALEDADMKTDEREQSSIVDIINASTDVAKQICCRTT--SECCVV---- A_0855_147 --CLPVFIVLLLLASLAAPNPLETRIQSDLIR AALEDADMKTDEREKSNLVDTINASTDIAKQICCRFT--SECCVVDEE- A_0055_186 MLCLPVFIILLLLASLGAPNPVETRIQSDLIR AALEDADMKTDEREQSSIVDIINASTDVAKQICCRIT--SECCVVDEE- A_0239_419 ---------------PAAPKPLETRIQSDLIR AALEDADMKTDEREQSSIVDIINASTDVAKQICCRIT--SECCVVDEE- A_0031_372 MLCLPVFII-LLLASPAAPNPLETRIQSDLIR AALEDADMKTDEREQSSIIDIINASTDVAKQICCRIT--SECCVDDEE- A_0025_401 MLCLPVFII-LLLASPAAPKPLETRIQSDLIR AALEDADMKTDEREQSSIVDIINASTDVAKQICCRIT--SECCVDDEE- A_0031_371 MLCLPVFVILLLLASLGAPNPVETRIQSDLIR AALEDAD----ERERTDIPSIIDAASDIAKQICCRIT--SECCVDDEE- A_0031_374 MLCLPVFIILLLLASPAAPNPLETRIQSDLIR AALEDAD----ERERTDIPSIIDAASDIAKQICCRIT--SECCVDDEE- ventricosusQ9BPE1 MLCLPVFIILLLLASPAAPNPLEKRIQSDLIR AALEDADMKTDERE---IVNIIDSISDVAKQICCEIT--VQCCVLDEE- K_0010_116 MLCLPVFILLLLLASTAAPNPSEKRMQSDLIR AALEDADMKTNERL--DLSDMVSKAKELVASVCCPNK--LSFCC----- K_0010_159 MLCIPVFIIPLLLASSAAPNPLEKRIQRDLIR ASLEDADMKTNERL--DLSEMVSKAKELVAIVCCPNN--LSFCCFKR-- K_0010_245 ------------------------RIQSDLIS EALEDADMKTNERL--DLSDMVSKAKELVASVCCPNN--LSFCCFQR-- K_0010_269 ----PVFILLLLLASPAAPNPSETRMQSDLIR AALEDADMKTNERL--DLSDMVSKAKELVASVCCPDN--LSFCCFQR-- K_0010_271 MLCLTVFILLFLLASHAAPTPSETRIQRDLIS AALEDDDMKTNERL--DLSDMVSKAKELVASVCCPTN--LSFCCF---- V_1302_185 MLCLPVFIILLLLASPAAPNPLKTSLQRDVLR AAPGDADMKTERF-----------WKELADGLCCPMI--TKCCIKEEAA V_1258_143 MLCLPVFIILLLLASPAAPNPLKTSLQRDVLR AAPGDADMKTERF-----------WKELADGLCCPMI--TKCCIKEEAA V_CG13_172 MLCLPVFIILLLLASPAAPNPLKTSLQRDVLR AAPGDADMKTERF-----------WKELANRFCCPMI--TKCC------ A_0855_255 MLCLPVFIILLLLASPAAPNPVETKLQSDLTR A---DADME---------------------------------------- V_1302_091 ----------------------ETKLQSDLTR A---DADMETEKY-----------LGEVRRAVCCEVFPGTDCCKL---- A_0055_001 M-CLPVFIILLLLASPAAPNPVETKLQSDLTR A---DGDMETEKY-----------LGEVRKAVCCEVFPGTDCCMI---- A_0239_416 MLCLPVFIILLLLASPAAPNPVETKLQSDLTR A---DGDMETEKY-----------LGEVRKAVCCEVFPGTDCCMI---- V_1302_092 --------------SPAAPNPFETKLQSDLTR A---DADMETEKY-----------LGEVRRAVCCEVFPGTDCCMG---- V_1302_095 ---------------------VETKLQSDLTR A---DADMETEKY-----------LGEVRRAVCCEVFPGTDCCMG---- V_1258_081 --------------SPAAPNPFETKLQSDLTR A---DADMETEKY-----------LGEVRRAVCCEVFPGTDCCMG---- V_1258_083 ---------------------VETKLQSDLTR A---DADMETEKY-----------LGEVRRAVCCEVFPGTDCCMG---- V_CG13_153 --------------SPAAPNPFETKLQSDLTR A---DADMETEKY-----------LGEVRRAVCCEVFPGSDCCMG---- A_0055_002 -------------ASPAAPNPVETKLQSDLTR A---DGDMETEKY-----------LGEVRKAVCCEVFPGSDCCAG---- A_0520_171 MLCLPVFIILLLLASPAAPNPVETKLQSDLTR A---DADMET---------------GEVRKSICCELRPHGNCCAG---- A_0520_172 MLCLPVFIILLLLASPAAPNPVETKLQSDLTR A---DADMET---------------GEVRKAVCCEVFPGSDCCAG---- A_0048_143 MLCLPVFIILLLLASPAAPNPVETKLQSDLTR A---DADMET---------------GEVRKAVCCEVFPGSDCCAG---- A_0048_142 MLCLPVFIILLLLASPAAPNPVETKLQSDLTR A---DADMET---------------GEVRKSICCELRPHGNCCAG---- A_0025_203 MLCLPVFIILLLLASPAAPNPVETKLQSDLTR A---DADMET---------------GEVRKAVCCEVFPGSDCCAG---- A_0885_150 MLCLPVFIILLLLASPAAPNPVETKLQGDLTR A---DADMET---------------GEVRKAVCCEVLPGSDCCSG---- A_0031_373 MLCLPVFIILLLLASPAAPNPVETKLQSDLTR A---DADMET---------------GEVRKAVCCEVYPGSDCCSG---- K_0010_060 MLCLPVFIILLLLASPAAPNPFETKLQSDLTR A---DADLETEKN-----------LGEVRKAICCEVFPGTDCCMG---- K_0010_266 MLCLPVFIILLLLASCAAPNPFETKLQSDLTL A---DAD------------------------------------------ ermineusAXL95559 -------------------------------- -------------------------GEVRKAVCCEVYPGSDCCSG---- caracteristicusAGK23239 MLCLPVFIILLLLASPAAPNPFETRLLNDLAR A---DADMETEKY-----------LGEVRKAVCCQVFPGSDCCPGF--- tessulatusAGK23242 MLCLPVFIILLLLASPAAPNPFETKLQSDSTR A---DADXETDKN-----------LDAVRKAICCDVFPGTDCCMG---- coronatusAGK23241 MLCLPVFIILLLLASPAVPEPFETKLQRDLTR A---DADMEN--------------LAKVRKAVCCEVLPGTDCCFG---- litteratusQ1A3Q7 MLCLPVFIILLLLASPAAPKSFETKVQSDLTR T---DGNMETEEN-----------LGEVRKVYCCLGVRDDWCCAGQIQI [Superfamily T-3 WF] [No Framework of T-3] A_0055_190 MLCLPVFIILLLLASPAAPNPVETRVQSDLIR-AGLE--------------------GASAKTDERFVLGFW---KHLLGRKK A_0520_310 MLCLPVFIILLLLASPAAPNPVETRVQSDLIR-AGLE--------------------GASAKTNERFVLSFW---SHLLGRKK A_0048_297 MLCLPVFIILLLLASPAAPNPVETRVQSDLIR-AGLE--------------------GASAKTNERFVLGFW---KHLLGRKK A_0055_188 MLCLPVFIILLLLASPAAPNPVETRVQSDLIR-AGLE--------------------GASAKTNERFFGFL----TKLFGRKK A_0239_365 MLCLPVFIILLLLASPAAPNPVETRVQSDLIR-AGLE--------------------GASAKTNERFFGFL----TKLFGRKK A_0239_366 MLCLPVFIILLLLASPAAPNPVETRVQSDLIR-AGLE--------------------GASAKTNERFLGFL----SKIFGRKK A_0855_256 --------------SPAAPNPLETRVQSDLIR-TGLE--------------------DASGKTNERFFKAV----GDFFKNL- A_0025_206 ----------------AAPNPVETRVQSDLIR-AGLE--------------------GASAKTNERFLSFL----SKLFGRKK A_0025_395 MLCLPVFIILLLLASPAAPNPVETRVQSDLIR-AGLE--------------------GASAKTNERFLGFL----SKIFGGKK ermineusAXL95620 MLCLPVFIILLLLVSAAAPNPLETRIQSDLIR-AGLE--------------------DASGKTNERFFGAIASAISKLFGGKK K_0010_061 MLCLPVFIILLLLSSPAAPNPSETRIQSDLIR-AALE--------------------DADMNSDERSLMG------------- K_0010_097 MLCLPVFILLLLLASPAAPNPSETRIQSDLIR-AALE--------------------DAD----------------------- K_0010_248 MLCLPVFILLLLLASPAAPNPSETRIQSDLIR-AALE--------------------DADMKADERFIGGLVSTIVNTLGKVFQG--------------- K_0010_243 MLCLPVFIILLLLASPAAPNPSETRIQSDLIR-AALE--------------------DADMKADERFIGGLVSTIVNTLGKVFQGWLLKRHLEGVPGYEM K_0010_104 ----PVFIILLLLASPAAPNPSETRIQSDLIR-AALE--------------------DADMKADERFIGGLIG--------------------------- K_0010_249 MLCLPVFIILLLLASSAAPNPLETRIQSDLIR-AALE--------------------DADMKADERFIGGLVSTIVNTLGKVFQG--------------- K_0010_246 MLCLPVFIILLLLASPAAPNPLETRIQSDLIR-AALE--------------------DADMNSDERSIMSIFSKLAPVLITVLSNVL---------GGE- K_0010_247 MLCLPVFIILLLLASSAAPNPLETRIQSDLIR-AALE--------------------DADMNSDERSLMGVFSKLAPVLITVLSNVL---------GGE- K_0010_111 --------------SPAAPNPSETRIQSDLIR-AALE--------------------DADMKDDERFIGGLIGTIVNT---------------------- K_0010_063 -LCLPVFLLLLLLASHAAPKPSETRIQSDLIR-AALE--------------------DADMNSDERSLMGMFKKIAPI---------------------- A_0855_129 -----------------------TRIQSNLIR-AALE--------------------DADIKTDKRIFGALAVSIFKPIIGAFKG A_1387_322 -----------------------TRIQSNLIR-AALE--------------------DADIKTDKRIFGALAVSFLKPIIDAIKG V_CG13_171 MLCLPVFIILLLLASPAAPNPLETRIQSNLIR-AGPE--------------------DADIKTDKRIFGGLVASILKPVIDAIKG V_1302_184 MLCLPVFIILLLLASPAAPNPLETRIQSNLIR-AGPE--------------------DADIKTDKRIFGGLVASILKPVIDAIKG V_1258_128 MLCLPVFIILLLLASPAAPNPLETRIQSNLIR-AGPE--------------------DADIKTDKRIFGGLVASILKPVIDAIKG V_CG13_173 MLCLPVFIILLLLASPAAPNPLETRIQSNLIR-AGPE--------------------DADIKTDKRIWGGLLTSIVKPIIDVVEG ventricosusQ9BPD4 MLCLPVFIILLLLASPAAPNPLQTRIQSNLIR-AGPE--------------------DANIKTDKRIFAGLLASILKPIIDAAKG A_0031_375 MLCLPVFIILLLLASPAAPNTLETRIQSNLIR-AGPE--------------------DADIKTDKRFFSGLLVKVLKPLVNASKADFGKYPS ermineusAXL95558 ------------LASPAAPNTLETRIQSNLIR-AGPE--------------------DADIKTDKRFFSGLLVKVLKPLVNASKADFGKYPS A_0239_364 MLCLPVFII-LLLASPAAPKPLETRIQSDLIR-AALE--------------------DADE-------------------------- A_0520_170 MLCLPVFIVLLLLASLAAPNPLETRIQSDLIR-AALE--------------------DADMKTDERFIGGLIGTIVNT--LGKVFQG A_0048_296 MLCLPVFIILLLLASLAAPNPLETRIQSDLIR-AALE--------------------DADMKADERFIGGLIGTIVNT--LGKVFQG A_0048_299 MLCLPVFILLLLLASPAAPNPSETRIQSDLIR-AALE--------------------DADMKADERFIGGLVSTIVNT--LGKVFQG striatusAAZ38457 MLCLPVFIMLLLLASPAAPNPLETRTQSDLIR-AALE--------------------DADAKPDERFLGGIFGGISLLSALINALSS magusQFQ61118 MLCLPVFIILLLLASPAAPKPLETRIQSDLIR-AAVE--------------------DADAKPDERFLGAVFGGISLLSTLIDALSS V_1302_329 --------------SPAAPNPVERRIQSDLIR-AGLE--------------------GADMETEERFIGALFGPVVDA--VTSLFKGRKK------------ V_1302_330 --------------SPAAPNPVERRIQSDLIR-AGLE--------------------VADMESEERFIGALFGPVVDA--VTSLFKGRKK------------ V_1278_191 ----PVFIILLLLASPAAPNPLETRIESDLIR-AGLE--------------------GADLKTEERFFGAFIGPAINA--LTSILKGRKK------------ V_CG13_175 MLCLPVFIILLLLASPAAPNPLETRIQSDLIR-AGLE--------------------GADMKTEERFLGALVGPALNA--LTSLLSGRKK------------ V_1302_150 -MCLPVFIILLLLASPAAPNPLETRIQSDLIR-AGLE--------------------GADMETEERFIGALVGPVVNA--LTSLFKGRKK------------ V_1258_142 MLCLPVFIILLLLASPAAPNPLETRIQSDLIR-AGLE--------------------GADMETEERFIGALVGPVVNA--LTSLFKGRKK------------ V_1302_151 -MCLPVFIILLLLASPAAPNPLETRIQSDLIR-AGLE--------------------GADMETEERFLGSL-PTYATI--FYRVVRNNQEALK--------- V_1258_074 MPFLLSLSILLLLPAPAAPTPVERRIQSDLIR-AGLE--------------------GADMETEERFLGSL-PTYATI--FYRVVRNNQEALK--------- V_1278_085 MLCHPVFIILLLFASPAAPNPLETRIQSDLIR-AGLE--------------------GVDMKTEERFLGILKYAIGPV--VNALLQGLQK------------ V_1278_087 -----VFILLLLFASPAAPNPLETRIQSDLIR-AGLE--------------------GVDMKTEERFLGILKYAIGPV--VNALLQGLQK------------ V_1278_086 MLCLPVFIILLLLASPAAPNPLETRIQSDLIR-AGLE--------------------GVDMKTEERFLGILKYAIGPV--VNALLQGLQK------------ K_0010_115 MLCIPAFIILLLLASSAATTLLDTRIQSDLIS-AAIE--------------------AADLNSDERSLRGVFSKRAPV--LITVLSNVRGG----------- K_0010_096 -----------------APNPLETRIQSDFIL-SALE--------------------DVDMNSDERYLMGVFSKLAPV--LVTWLSNVLGGE---------- ermineusAXL95656 MLCLPVFIILLLLASPAAPNPLETRIQSDLIR-AGLE--------------------GVDMKTEERFLGILKYAIGPV--VNALLQGLQK------------ tessulatusAAG60424 MLCLPVFIILLLLASPAAPNPLERRIQSDLIR-AVLE--------------------DADMKTEKGILSSIMGALGGI--VG-------------------- A_0885_149 MLCLPVFIILLLLASPAAPNPLETRVQSDLIR-AGLE--------------------DASGKTNQRFFGALGKIITNV--LAGKK----------------- A_0875_095 MLCLPVFIVLLLLASLAAPNPLETRIQSDLIR-AALE--------------------DASGKTNQRFFGALGKIITNV--LAGKK----------------- A_0875_092 MLCLPVFIVLLLLASLAAPNPLETRIQSDLIR-AALE--------------------DASGKTNERFFGALANIISNV--LGGKK----------------- A_0239_417 MLCLPVFIILLLLASPAAPNPVETRVQSDLIR-AGLE--------------------DASGKTNERFLGALGRIIGQV--IGGKK----------------- A_0048_290 --------------SPAAPNPLETRVQSDLIR-AGLE--------------------DASGKTNERFLGALGAALGKL--FGGKK----------------- A_0055_194 MLCLPVFIILLLLASPAAPNPLETRVQSDLIR-AGLE--------------------DASGKTNERFLGALGKIIGQV--FGGKK----------------- A_0239_367 MLCLPVFIILLLLASPAAPNPLETRVQSDLIR-AGLE--------------------DASGKTNERFLGALGKIIGQV--FGGKK----------------- A_0520_313 --------------SPAAPNPLETRVQSDLIR-AGLEEKTVRIGTRRVDTSSHPNGRDASGKTNERFLGAIGKILGQV--FGGKK----------------- A_0520_311 --------------SPAAPNPLETRVQSDLIR-AGLE--------------------DASGKTNERFLGAIGKILGQV--FGGKK----------------- A_0048_294 --------------SPAAPNPLETRVQSDLIR-AGLE--------------------DASGKTNERFLGAIGKILGQV--FGGKK----------------- A_0520_312 --------------SPAAPNPLETRVQSDLIR-AGLE--------------------DASGKTNERFLGAIGTALGKL--FGGKK----------------- A_0048_291 --------------SPAAPNPLETRVQSDLIR-AGLE--------------------DASGKTNERFLGAIGSILGKL--FGGKK----------------- A_1387_323 MLCLPVFIILLLLASPAAPNPLETRIQSNLIR-AGLE--------------------DASGKTNERFLQAAASILKNL--FGGKK----------------- A_0039_121 MLCLPVFIILLLLASPAAPNPLETRVQSDLIR-AGLE--------------------DASGKTNERFLQALGSVFKNL--FGRKK----------------- A_0031_284 MLCLPVFIILLLLASPAAPNPLETRVQSDLIR-AGLE--------------------DASGKTNERFLQALGSVFKNL--FGRKK----------------- A_0025_402 MLCLPVFIILLLLASPAAPNPLETRVQSDLIR-AGLE--------------------DASGKTNERFLEAVGNFFKNL------------------------ A_0048_292 --------------SPAAPNPLETRVQSDLIR-AGLE--------------------DASGKTNERFFATIGKMISDL--IGGKK----------------- A_0055_193 --------------SPAAPNPVETRVQSDLIR-AGLE--------------------DASGKTNERFFATIGKMISDL--IGGKK----------------- A_0039_118 MLCLPVFIILLLLASPAAPNPLETRVQSDLIR-AGLE--------------------DASGKTNERSWKAYLAHLSNM--HGGKK----------------- A_0031_282 MLCLPVFIILLLLASPAAPNPLETRVQSDLIR-AGLE--------------------DASGKTNERSWKAYLAHLSNM--HGGKK----------------- A_0025_396 MLCLPVFIILLLLASPAAPNPLETRVQSDLIR-AGLE--------------------DASGKTNERFLESVGKFFKNM--VPVRKPMNGFWAL--------- A_0025_397 MLCLPVFIILLLLASPAAPNPVETRVQSDLIR-AGLE--------------------DASGKTNERFLESVGKFFKNM--VPVRKPMNGFWAL--------- A_0025_394 MLCLPVFIILLLLASPAAPNPLETRVQSDLIR-AGLE--------------------DASGKTNERILPGHGCKFMYH--FGE------------------- A_0025_400 MLCLPVFIILLLLASPAAPNPVETRVQSDLIR-AGLE--------------------DASGKTNERILPGHGCKFMYH--FGE------------------- ermineusAXL95620 MLCLPVFIILLLLVSAAAPNPLETRIQSDLIR-AGLE--------------------DASGKTNERFFGAIASAISKL--FGGKK----------------- [Superfamily T-4] [Framework V] [ /-----Signal-----/------------Pro-----------/ /------CC------CC--------] V_CG13_186 -MNCLPVLLIVLLLIAHSSQVDDISKLKLTRAMLRRGWKETVLER FYEALDVCCSVAY-FCCKLQRDLGQA V_1258_129 -MNCLPVLLIVLLLIAHSSQVDDISKLKLTRAMLRRGWKETVLER FYEALDVCCSVAY-FCCKLQRDLGQA V_1302_010 -MNCLPVLLIVLLLIAHSSQVDDISKLKLTRAMLRRGWKETVLER FYEALDVCCSVAY-FCCKLQRDLGQA praecellensATF27812 -MKCLPVFFIVLLLIAHSSQVVEHSKLKRTK-MLRRSTTIEKIEV ALE---VCCLASSTFCCAAKS----- andremeneziATF27558 -MNCLPLFFIVLLLIAHSSQVVEHSKLKRTK-MLRRSTTRDDDEE ALE---LCCAAGSTFCCAARWHF--- [Superfamily U-1a] [Framework XII] [ /--------Signal--------/---Pro--/ /-C---C--C-----C-CC----C-----C-------------------] A_0055_054 ----------------------------KLEVK SDCSSDCVTCDDEVPCGCCGNAICHKTGVCQLVSNTY-DYY--DYY---- A_0039_088 MNRMGFFLTLTVVVLLTSLTYTDGAPAEKLEVK SDCSSDCVTCDDEVPCGCCGNAICHKTGVCQLVSNTY-DYY--DY----- A_0048_210 --------------------------AEKLEVK SECPGDCMTCDTTLPCGCCGNVICHKTGVCQSVGGSN-DY---DYY---- A_0855_103 --------------------------AEKLEVK SDCSSDCVTCDDDVPCGCCGNVICHKTGVCQSVGGSN-DYY--DY----- A_0875_072 MNRMGFFLTLTVVVLLTSLTCTDGAPAEKLEVK SDCSSDCVTCDDDVPCGCCGNVICHKTGVCQSVGGSN-DYY--DY----- A_0885_066 MNRMGFFLTLTVVVLLTSLTYTDGAPAEKLEVK RECPGDCMTCDTTLPCGCCGNVICHKNGVCQSVGG--------------- V_1302_180 MNRMGFFLMLTVAVFFTSLICTDGAPADKLEVK RDCSGDCVTCDDDVPCGCCGNVICHKTGVCQLVSDPYGDY---DY----- V_1258_049 MNRMGFFLMLTVAVFFTSLICTDGAPADKLEVK RDCSGDCVTCDDDVPCGCCGNVICHKTGVCQLVSNPYGDY---DY----- V_CG13_034 ----------------------------KLEVK RDCSGDCVTCDDDVPCGCCGNVICHKNGVCQLVSDPYGDY---DY----- A_0520_330 MNRMGFFLTLTVVVLLTSLTCTDGAPAEKLEVK SECPGDCMTCDTTLPCGCCGNVICHKNGVCQLVSDPYGDY---DY----- A_0048_209 MNRMGFFLTLTVVVLLTSLTCTDGAPAEKLEVK SECPGDCMTCDTTLPCGCCGNVICHKNGVCQLVSDPYGDY---DY----- A_0239_048 MNRMGFFLTLTVVVLLTSLTYTDGAPAEKLEVK SECPGDCVTCDTTLPCGCCDNAICNKNGVCQFVSDPYGDY---DYY---- V_1278_019 --------------------------AEKLEVK SDCSWDCVTCSSDAPCGCCGNVICHNNGICQLVSDPYGDY---NY----- A_0031_379 MNRMGFFLMLTVAVLFTSLICTDGAPAEKLEVK GDCSGDCMTCDTTLPCGCCGNVICHENGVCQLVSDPYGDY---------- A_0031_380 --------------------------AEKLEVK SDCSGDCETCDDDVPCGCCGNVICHENGVCQLVSDPYGDY---------- A_0055_064 MNRMGFFLTLTVVVLLTSLTYTDGAPAEKLEVK SDCSGDCETCDDDVPCGCCGNVICHENGLCQLVSDPYGDY---DYY---- A_0039_089 MNRMGFFLTLTVVVLLTSLTYTDGAPAEKLEVK SDCSGDCETCDDDVPCGCCGNVICHENGLCQLVSDPYGDY---DYY---- A_0025_157 MNRMEFFLTLTVVVLLTSLTYTDGAPAEKLKVK RECPGDCMTCDTTLPCGCCGNIICHENGVCQSVGR--------------- A_0239_049 MNRMGFFLTLTVVVLLTSLTYTDGAPAEKLEVK SDCSGDCETCDDDVPCGCCGNVICHENGLCQLVSDPYGDY---DYY---- A_1387_181 MNRMGFFLTLTVVVLLTSLTYTDGAPAEKLEVK SDCSWDCVTCDDDVPCGCCGNVICHETGVCQLVSDPYGDYY--DYY---- K_0010_460 MNRMGFFLTLTVVVLLTSLTYTDGAPAEKLEVK SDCSWDCMTCDTTLPCGCCGNVICHENGVCQSV----------------- praecellensATF27819 MNKMGFFLTLTIAMLLTSLIRTDGA--EKLKIK RDCPSNCVTCGKGPKCGCCDNARCI-NELCQIVGGRRGSNRNVDYYDNNN [Superfamily U-1b] [Framework VI/VII] [ /-----------Signal-----/---Pre--/ /-----C--C-----CC--C----C--------] V_CG13_033 MNRMGFFLTLTVVVLLTSLTCTDGAPAEKLEVK RDFEKRCVPCAPGYKCCGVCVGSSCTGDQIPAK V_1302_183 MNRMGFFLTLTVAVLLTSLTCTDGAPAEKLEVK RDFEKRCVPCAPGYKCCGVCVGSSCTGDQIPAK V_1258_050 MNRMGFFLTLTVVVLLTSLTCTDGAPAEKLEVK RDFEKRCVPCAPGYKCCGVCVGSSCTGDQIPAK [Superfamily U-2] [Framework VI/VII] [ /-------Signal---------/-------Pro------------/ /--C--C---CC-----C----C-------] A_0239_053 MNRMGFFLMLAVAVLLTSFVCTEAAPANAPKIKRFRDVLVRHQLLKT QDPCDYCTYYCCS--NQCQREPCSP------ A_0875_073 MNRMGFFLTLTVAVLLTSLICTEAVPTDERE-MER---VFSHVLLGK ENGCSFCKTLCCPPKRVCQWSGCSLA----- A_0855_237 MNRMRFFLTLTVAVLLTSLICTEAVPTDERE-MER---LFSHVL--- ------------------------------- A_0239_052 -----------------------AVPTDERE-MER---LFSHVLLGK ENGCIFCKTWCCPPKRVCQWSGCRPA----- A_0855_020 ----------------------EAVPTDERE-MER---LFSHVLLGK ENGCSFCKIWCCPPKRVCQSSGCRPA----- V_1302_182 MNRMGFFLTLTVAVLLTSLTCTEAVPTDERE-MER---LFSHVLLGR ERDCPFCTIWCCPPDFVCQSSGCRPA----- V_1258_048 ----------------------EAVPTDERE-MER---LFSHVLLGR ERDCPFCKIWCCPPDLVCQSSGCRPA----- A_0031_026 -----FFLTLIVAVLLTSLICTEAVPTYERE-MER---LFSHALLGK ENDCPFCKVWCCPPELVCQPSGCRPA----- A_0055_065 MNRMGFFLTLTVAVLLTSLICTEAVPTYERE-MER---LFSHVLLEK ENDCPFCKIRCCPPDLVCQSSGCRPA----- A_0039_087 MNRMGFFLTLTVAVLLTSLICTEAVPTYERE-MER---LFSHVLLEK ENDCPFCKIRCCPPDLVCQSSGCRPA----- A_0031_027 -----FFLTLIVAVLLTSLICTEAVPTYERE-MER---LFSHVLLEK ENDCPFCKIRCCPPDLVCQSSGCRPA----- A_0239_051 MNRMGFFLTLTVAVLLTSLICTEAVPTDERE-MER---LFSHALLGK KNDCPFCKVWCCPPELVCQPSGCRPA----- V_CG13_021 ----------------------EAVPTDERE-MER---LFSHVLLSD RTGCPWCKVMCCPP-GFCQSSGCHPGYGTAV V_1302_181 ----------------------EAVPTDERE-MER---LFSHVLLSD RTGCPWCKVMCCPP-GFCQSSGCHPG----- amadisAXL93751 MIRMGFFLTLTVAVLLTSLTCSEAVPTDKRE-MER---LFDRILLKD QRQCPYCVVHCCPP-SYCQASGCRPP----- [Superfamily V-1a] [Framework XV] [ /----------Signal------/----------Pro-----------/ /-C--C----CC--C-C-------C-C--/Po] A_0875_115 MSTPRMMPLILLLLLPLAIRCGDGQAIQGDRGPSARLLRGGKIHDLPVK KRC----------------------------- A_0025_174 ----------LLLLLPLAIRCGDGQAIQGDTGSSARLLRRGKIHDLPVK KRC---DGAKCSGRCFCPFGEDQKCTCLSMGK A_0885_312 ---------------------------QGDRGPSARLLRGGKIHDLPVK KRCATCEGADCCGKCLCPFGEDHTCTCVSMGK V_1278_091 MSTPRMMPLILLLLLPLAIRCGDGQAIQGDSDPSARLLRGGKIHDLPVK KRCVTCSGAECCGKCICPFGEDKTCNCASI-- A_0855_151 MSTPRMMPLILLLLLPLAIRCGDGQAIQGDRGPSARLLRGGKIHDLPVK KRCTTCESAECCGRCVCAFGDAYRCTCVLTGK A_0855_152 MSTPRMMPLILLLLLPLAIRCGDGQAIQGDRGPSARLLRGGKIHDLPVK KRCVTCEGDECCGKCLCPFG------------ ermineusAXL95645 MSTPRMMPLILLLLLPLAIRCGDGQAIQGDRGPSARLLRGGKIHDLPVK KRCATCEGADCCGKCLCPFG------------ A_0885_311 ---------------------------QGDRGPSARLLRGGKIHDLPVK KRCVTCEGDECCGKCLCPFG--RKCHCASIGK V_CG13_029 -------------------RCGDGQAIQGDSDPSARLLRGDKEHDLSVK ATCGTCKGTKCCGRCICPWG--KNCACQRWGK V_1302_127 MSTPRMMPLILLLLLPLAIRCGDGQAIQGDSDPSARLLRGDKEHDLSVK ATCGTCKGTKCCGRCICPWG--KNCACQRWGK V_1258_004 MSTPRMMPLILLLLLPLANRCGDGQAIQGDSDPSARLLRGDKEHDLSVK ATCGTCKGTKCCGRCICPWG--KNCACQRWGK A_0885_104 ---------------------------QGDRGPSARLLRGGKIHDLPVK KRCATCNGTSCCGRCVCPWG--KNCVCQRWGK A_0025_175 ----------LLLLLPLAIRCGDGQAIQGDSDPSARLLRGGKIHDLPVK KRCATCNGTSCCGRCACPWG--KNCVCQRWGK A_0039_079 MSTPRMMPLILLLLLPLAIRCGDGQAIQGDSDPSARLLRGGKIHDLPVK KRCVTCNGTSCCG------------------- A_0875_113 MSTPRMMPLILLLLLPLAIRCGDGQAIQGDSDPSARLLRGGKIHDLPVK KRCVTCNGTSCCGR------------------ V_1302_125 MSTPRMMPLILLLLLPLAIRCGDGQAIQGDSDPSARLLRGGKIHDLPVK KRCVTCNGTSCCGRCVCPWG--KTCGCQRWGK V_1302_126 MSTPRMMPLILLLLLPLAIRCGDGQAIQGDSDPSARILRGGKIHDLPVK KRCVTCNGTSCCGRCVCPWG--KTCGCQRWGK A_0031_254 MSTPRMMPLILLLLLPLAIRCGDGQAIQGDSDPSARLLRGGKIHDLPVK KRCVTCNGTSCCGRCVCPWG--KTCGCQRWGK A_1387_247 MSTPRMMPLILLLLLPLAIRCGDGQAIQGDRGPSARLLRGGKIHDLPVK KRCGTCNGTSCCGRCVCPWG--KTCSCQRWGK A_1387_249 ----------------------DGQAIQGDSDPSARLLRGGKIHDLPVK KRCGTCNGTSCCGRCVCPWG--KTCSCQRWGK A_0048_152 --------LILLLLLPLAIRCGDGQAIQGDSDPSARLLRGGKIHDLPVK KQCGTCNGTRCCGKCICPWG--KTCFCHRWGK A_0055_111 ----------LLLLLPLAIRCGDGQAIQGDSDPSARLLRGGKIHDLPVK KHCGTCNGTSCCGRCICLWG--QTCFCQRWGK virgoB3FIA5 -----MMPVILLLLLSLAIRCADGKAVQGDSDPSASLLTGDKNHDLPVK RDCTTCAGEECCGRCTCPWG--DNCSCIEWGK flavidusAFU50812 MSTPRMTPFILLLLFSLTIRCGDGKAIQGDRDPSASLLTGDKNHDLSVQ IDCGTCDGEECCGVCICSFG---NCSCTPWGK praecellensATF27820 MSTPRMMPLVLLLLLSLATRCGDGQAIQGDRRLSARLLRGYKERGLSIK -TCGTCNGARCCGLCPCSPGE-KNCSCLPFGK andremeneziATF27571 MSTPRMMPLVLLLLLSLATHCGDGQAIQGDRRLSARLLRGYKERGLSIK -TCGTCNGARCCGLCPCSPGE-KNCSCLPFGK magusDAC80604 MSTPRMMLLILLLLLPLETPCGDGQAIQGDRRLRASLLSRYKEYNRPVK -NCKSCGGPECCGRC----------------- [Superfamily V-1b] [No Framework] [ /-------Signal---------/---------Pro------------/ /--C-----C---------------] A_0039_077 MSTPRMMPLILLLLLPLAIRCGDGQAIQGDRGPSARLLRRGKIHDLLVK -RGCAAYRPCPSKLWQ-RQ------ A_0875_112 MSTPRMMPLILLLLLPLAIRCGDGQAIQGDRGPSARLLRRGKIHDLLVK -RGCAAYQPCPSKLWQ-RQ-DS--- A_0025_239 MSTPRMMPLILLLLLPLAIRCGDGQAIQGDRGPSARLLRRGKIHDLLVK -SVCAAYRPCRPRLWQ-RQ-DS--- A_0239_437 MSTPRMMPLILLLLLPLAIRCGDGQAIQGDRGPSARLLRGGKIHDLLVK -RGCAAWRPCP-------------- A_0855_150 MSTPRMMPLILLLLLPLAIRCGDGQAIQGDRGPSARLQRRGKIHDLLVQ -RRCGAWQWC--------------- A_0239_436 MSTPRMMPLILLLLLPLAIRCGDGQAIQGDRGPSARLLRGGKIHDRLVK -RRCGAWQWCPPKLWQ-RQ-DS--- A_0031_252 MSTPRMMPLILLLLLPLAIRCGDGQAIQGDRGPSARLQRRGKIHDLLVQ -RRCGAWQYCPPKLWQ-SQ-DS--- A_0031_255 --------------------CGAGQAIQGDRGPSARLQRRGKIHDLLVQ -RRCGAWQYCPPKLWQ-SQ-DS--- A_0520_133 MSTPRLMPLILLLLLPLAIRCGDGQAIQGDRGPSARLLRGDKIHNQLVK RRRCGAWQYCPKKLWQ-RQ-DS--- A_0048_153 MSTPRLMPLILLLLLPLAIRCGDGQAIQGDRGPSARLLRGDKIHNQLVK RRRCGAWQYCPKKLWQ-RQ-DS--- A_0520_131 ----------------------DGQAIQGDRGPSARLLRGGKIHDQLVK RRRCGAWQRCPPRLWQ-RQ-DS--- A_0048_154 MSTPRMMLLILLLLLPLAIRCGDGQAIQGDSDPSARLLRGGKIHDQLVK RRRCSAWRRCPPKLWQ-RQ-DS--- ermineusAXL95696 MSTPRLMPLILLLLLPLAIRCGDGQAIQGDRGPSARLLRGDKIHNQLVK RRRCGAWQYCPKKLWQ-RQ-DS--- A_0048_155 MSTPRLMPLILLLLLPLAIRCGDGQAIQGDRGPSARLLRGGKNHDLQVK -TVCAAWRPCQ-KLWQ-RQ-DS--- A_0520_130 MSTPRLMPLILLLLLPLAIRCGDGQAIQGDRGPSARLLRGGKIHDLQVK -TVCAAWRPCQ-KLWQ-RQ-DS--- ermineusAXL95731 MSTPRLMPLILLLLLPLAIRCGDGQAIQGDRGPSARLLRGGKNHDLQVK -TVCAAWRPCQ-KLWQ-RQ-DS--- A_0875_114 ---------------------------------------RGKIHDLLVK -RRCGAWQWCP-MLWQVRLPGVLV- A_0875_116 ---------------------------------------RGKIHDLLVK -RRCGAWQWCP-MLWQVRLPVESVK A_0855_025 ---------------------------------------RGKIHDLLVK -RRCGAWQWCP-MLWQVRLPDGRRP A_0055_059 ---------------------------------------RGKIHDLLVK -RRCGAWQWCP-MLWQVRLPDGRRP A_0055_060 ---------------------------------------MRCFHDLLVK -RRCGAWQWCP-MLWQVRLPDGRRP A_0520_129 ---------------------------------------RGKIHDLLVK -RRCGAWQWCP-MLWQVRLPDGRRP A_0025_176 ---------------------------------------RGKIHDLLVK -RRCGAWQWCP-MLWQVRLPDGRRP A_0031_253 ---------------------------------------RVKIHDLLVK -RRCGAWQWCP-MLWQVRLPDGRRP A_1387_248 MSTPRMMPLILLLLLPLAIRCGDGQAIQGDRGPSARLLRGGKIHDLLVK -RGCAAWRPCQ-MLRQVRLPDGRRP ermineusAXL95577 MSTPRMMPLILLLLLPLAIRCGDGQAIQGDRGPSARLQRRGKIHDLLVQ -RRCGAWQWCP-MLWQVRLPDGRRP [Superfamily Y-1] [Framework XVII] [ /------Signal------/---------Pro-------/ /-C------C-------CC----C----CC-----C] A_0855_002 MQKATVLILAILLLLPLSTAQDDEGSQENAAQRE------ ------------------------------------- V_1278_095 MQKATVLILAILLLLPLSTAQDDEGSQENAAQRE------ ------------------------------------- A_0055_164 MQKATVLLLAILLLLPLSTAQDDEGSQENAVQRE------ ------------------------------------- A_0885_062 MQKATVLILAILLLLPLSTAQDDEGSQENAAQRELPMTTR --LGGVGDPCDEPAGKPCCCRLKCVSKRCCPTTNGC- A_0025_312 MQKATVLILAILLLLPLSTAQDDEGSQENAAQRELPITTR --LGGVGDPCDEPAGKPCCCGLKCVSKRCCPTTNSC- A_0039_069 MQKATVLILAILLLLPLSTAQDDEGSQENAVQRELPITTR --CGGDGKPCDEPAGQVCCRGLKCVSMRCCRTTDGC- A_0055_163 MQKATVLILAILLLLPLSTAQDDEGSQENAVQRELPITTQ --CGGDGKPCDEPAGQVCCHGLKCVSMRCCRTTDGC- A_0875_110 MQKATVLILAILLLLPLSTAQDDEGSQENAVQRELPMTTR --CGGDGKPCDEPAGQVCCHGLKCVSMRCCRTTDGC- A_0239_223 MQKATVLILAILLLLPLSTAQDDEGSQENAAQRELPITTR --CGGVGDSCDEPAGESCCSQLKCVSNLCCPTTDGCG A_0520_083 MQKATVLILAILLLLPLSTAQDDEGSQENAVQRELPMTTR --CGGVGDPCDEPAGQSCCSRLKCVSMRCCPTTDGC- A_0048_199 MQKATVLILAILLLLPLSTAQDDEGSQENAVQRELPMTTR --CGGVGDPCDEPAGQSCCSRLKCVSMRCCPTTDGC- A_1387_231 MQKATVLILAILLLLPLSTAQDDEGSQEKTAQKELLITTL --CGGVGYPCNEPAGQSCCSRLKCVSMRCCPTTDGC- betulinusAMP44751 MQKATVLILAILLSLPLSTAQDDEGSQENAAQRDVDITTL APCGGTGDPCNEPAGQLCCSLLKCVSSHCCPTTDGC- caracteristicusB4YSU8 MQKATVLLLALLLLLPLSTAQDAEGSQEDAAQREVDIATR --CGGTGDSCNEPAGELCCRRLKCVNSRCCPTTDGC- [Superfamily Y-2] [New Framework] [ /--------Signal-----/------Pro---------/ /---C--C-C-------C-----C----C----C----C-C-------C-----C----C] A_0048_129 MQKATVLLLAILLLLPLASVQDDKDSVLDKTKTERDWKSR DESLCDDCRCNHLIRGICVPERDCTRGDCIAARCSPGRCECKYFHMGKCVQKDECMDEEC A_0885_063 ---------AILLLLPLATIQDDKDSVLDKTKTERDWRSR DENQCDECRCNHLNRGICVPKNECSDKNCTAATCSDGECMCQYFRQGRCVSQARCKDEEC A_0885_064 ---------AILLLLPLATIQDDKDSVLDKTKTERDWRSR DENQCAECNCNNLKQGICVHKLDCSSENCPAATCSDGKCECKFFHLGMCVHEDECKDQVC A_0239_222 MQKATVLLLAILLLLPLATIQDDKDSVLDKTKTERDWRSR DENQCDECKCNHLNRGICEKQTFCSESNCTTATCADGECMCHHFPQGRCVPQSWCKHT-C A_0031_294 MQKATVLLLAILLLLPLATIQDDKDSVLDKTKTERDWRSR DENQCDECKCNHLNRGICEQKKYCSDENCTAATCSDGECMCHYFQQGRCVPQAWCKHT-C A_0025_313 MQKATVLILAILLLLPLATIQDDKDSVLDKTKTERDWRSR DENQCDECKCNHLNRGICEQKKYCSDENCTAATCSDGECMCHYFQQGRCVPQAWCK---- [Cerm Superfamily 01] [Framework VI/VII] [ /-----Signal-----/-------Pro--------/ /----C-------C-------CC---C-----C--------] V_CG13_115 MRFYMLLAVALLLNSVMSTDDVSSHETDAT--RGEKR DDQNPCPSSHPNFCLSLKVQNCCETDCDSGNRCNSDSYQIWE V_1278_023 MRFYMLLAVALLLNSVMSTDDVSSHETDAT--RGEKR DDQNPCPSSHPNFCLSLKVQNCCEADCDSGNRCNSNSYQIWE V_1302_033 MRFYMLLAVALLLNSVMSTDDVSSHETDAT--RGEKR DDQNPCPSSHPNFCLSLKVQNCCKTDCDPGNQCTSDNYRIWE V_1258_033 MRFYMLLAVALLLNSVMSTDDVSSHETDAT--RGEKR DDQNPCPSSHPNFCLSLKVQNCCKTDCDPGNQCTSDNYRIWE K_0010_204 --------------------DVSIHQTGAT--RREKR DDQHPCPLDLPHFCLSLKVDNCCKLQCDSGNRCNSKTYKI-- K_0010_206 --------------------DVSIHQTGAT--RREKR DDQNPCPRQLPYYCPYGI---CCKIQCDSRNRCNGK-YEIWL ermineusAXL95604 MRFYMLLAVALLLTSVMSTDDVSIHQTGAT--RREKK DDDSPCPPAHPHYCHSLKVLTCCKTECDLGNRCNSYDYRIWE magusDAC80611 MRFYMLLAVALLLNSVMSTDDVSIHQTDPT--RLEKR D-KSRCPEDYPKFCQSLKVDTCCRDGCKGRNQCKSKKYLIWE californicusD6C4K2 MKFYLLLTAALLLTAVIIEAAPTDHQDEARDLMREER DDKSNCPISHPNYCSFTPV--CCKHECLSNNKCSSSEFIPGQ [Cerm Superfamily 02] [Framework VI/VII] [ /-----Signal--------/------Pro-------/ /--C--C---CC----C----C-------] A_0855_259 --------------------ARLPDKAFRQRQSQYIQR IQRCLFCGFTCCSPNYCQGLTCVIV----- V_CG13_070 MRFLLFLCIVVLLTSFRETEARLPDKAFRQRQSQYIQR IQRCPWCGFICCSPNYCQGVTCMVV----- A_0885_013 MRFLLFLCIVVLLTSFRETEARLPDKAFRQRQSQYIQR IQRCPFCGFTCCSPNYCQGLTCTIV----- A_0039_114 MRFLLFLCIVVLLTSFRETEARLPDKAFRQRQSQYIQR IQRCPFCGFTCCSPNYCQGLGCVIV----- V_1258_021 MRFLLFLCIVVLLTSFRETEARLPDKAFRQRQSQYIQR IQRCPWCGHSCCSPNYCQGLNCVVV----- V_1302_013 MRFLLFLCIVVLLTSFRETEARLPDKAFRQRQSQYIQR IQRCPWCGHSCCSPNYCQGLNCVVV----- V_1278_089 MRFLLFLCIVVLLTSFRETEARLPDKAFRQRQSQYIQR IQRCPWCGHSCCSPNYCQGVNCVVV----- A_0875_018 MRFLLFLCIVVLLTSFRETEARLPDKAFRQRQSQYIQR IQRCLFCGHICCSPNYCQGLSCVIV----- A_0055_112 MRFLLFLCIVVLLTSFRETEARLPDKAFRQRQSQYIQR IQPCPFCGHICCSPNYCQGLSCVIV----- A_0520_337 MRFLLFLCIVVLLTSFRETEARLPDKAFRQRQSQYIQR IQRCPFCGHICCSPSYCQGLSCVIV----- A_0048_289 MRFLLFLCIVVLLTSFRETEARLPDKAFRQRQSQYIQR IQRCPFCGHICCSPSYCQGLSCVIV----- A_1387_066 MRFLLFLCIVVLLTSFRETEARLPDKAFRQRQSQYIQR IQRCPFCGFTCCSPNYCQGLSCVIV----- A_0025_186 MRFLLFLCIVVLLTSFRETEARLPDKAFRQRQSQYIQR IQRCPFCGFTCCSPNYCQGVTCQIV----- A_0031_091 MRFLLFLCIVVLLTSFRETEARLPDKAFRQRQSQYIQR SQRCLFCGHICCSPNYCQGLTCVIV----- ermineusAXL95477 MRFLLFLCIAVLLTSFRETEARLPDKAFRQRQSQYIQR IQRCPWCGHSCCYPNYCQGVTCKIA----- quercinusP58843 -------------------------------------- DQSCPWCGFTCCLPNYCQGLTCTVI----- betulinusAMP44726 MRFLLFLCIVVLLTSFRETEARLPDKAFRQRQSQYIQR VQRCPWCGFICCPPNYCQGLTCQVVEADDE [Cerm Superfamily 03-1] [Framework XIV] [ /-------Signal--------/-----------Pro-------/ /------C---C---C-----C----] A_0855_136 MKLSMMFILSLVLTLSMTDGLILLAKKGGRTFREHSPDSMDLQTR QLKRGPSCPEDCKTLCLYDGICQ--DE A_0885_144 MKLSMMFILSLVLTLSMTDGFILLAKKGGRTFREHSPDSMDLQTR QLKRGPSCPDDCKTLCLYDDICQ--PE V_1302_021 ------------MTLSMTDGFIHLAKKGGRTFREHSPDSMDLQTR QLKRDPSCPPECMTLCLYDGICQ--D- A_0055_011 ------------MTLSMTDGFILLAKKGGRILWEHSPDPMDLQTR QLKRGPSCPNDCQTLCLYDGICQ--DE A_0039_017 ---------------SMTDGFILLAKKGGRILWEHSPDPMDLQTR QLKRGPSCPNDCQTLCLYDGICQ--DE A_0520_266 MKLSMMFILSLVLTLSMTDGFILLAKKGGRTFREHSPDSMDLQTR QLKRGPSCPQDCKTLCLYDGICQTK-- A_0048_223 MKLSMMFILSLVLTLSMTDGFILLAKKGGRTFREHSPDSMDLQTR QLKRGPSCPQDCKTLCLYDGICQTK-- A_0031_162 MKLSMMFILSLVLTLSMTDGFILLAKKGGRTFREHSPDSMDLQTR QLKRGLSCPEDCKTLCLYDGICQPKPE A_0239_026 MKLSMMFILSLVLTLSMTDGFIRLAKKGGRTFREHSPDSMDLQTR QLKRGPSCPDDCQTLCLFD-ICQ--DE A_0025_162 MKLSMMFILSLVLTLSMTDGFILLAKKGGRILWEHSPDPMDLQTR QLKRDPLCPDDCQTLCLYDNICQ--DE ermineusAXL95557 MKLSMMFILSLVLTLSMTDGFILLAKKGGRTFREHSPDSMDLQTR QLKRGPSCPEDCKTLCLYDGICQ--DE V_CG13_150 MKLSMMFILSLVLTLSMTDGFIRRAEKGGRTFRQRRPYSMDLQTR LI---FECPPGCPQICLSTSIC---D- V_1302_022 MKLSMMFILSLVLTLSMTDGFIRRAEKGGRTFRQRRPYSMDLQTR LI---FECPPGCPQICLSTSIC---D- V_1258_018 MKLSMMFILSLVLTLSMTDGFIRRAEKGGRTFRQRRPYSMDLQTR LI---FECPPGCPQICLSTSIC---D- A_0055_010 MKLSMMFILSLVLTLSMTDGFIRRAEKGGRTLRQRRPYSMDLQTR LI---P--------------------- A_0039_015 MKLSMMFILSLVLTLSMTDGFIRRAEKGGRTLRQRRPYSMDLQTR LI---P--------------------- A_0855_137 MKLSMMFILSLVLTLSMTDGFIRRAEKGGRTLRQRRPYSMDLQTR LI---PDCPLGCSDSCVYTGICY--D- A_0885_145 MKLSMMFILSLVLTLSMTDGFIRRAEKGGRTLRQRRPYSMDLQTR LI---PDCPLGCSDSCVYTGICY--D- A_0239_027 MKLSMMFILSLVLTLSMTDGFIRRAEKGGRTLRQRRPYSMDLQTR LI---PDCPLGCSDSCVQTGICY--D- A_0048_224 MKLSMMFILSLVLTLSMTDGFIRRAEKGGRTLRQRRPYSMDLQTR LI---PDCPLGCSDSCVQTGICY--D- A_0031_161 MKLSMMFILSLVLTLSMTDGFIRRAEKGGRTLRQRRPYSMDLQTR LI---PDCPLGCSDSCVQTGICY--DK A_0039_016 MKLSMMFILSLVLTLSMTDGFIRRAEKGGRTLRQRRPYSMDLQTR WI---PDCPLGCSDSCVYTGICY--DE A_0875_021 MKLSMMFILSLVLTLSMTDGFIRRAEKGGRTLRQRRPYSMDLQTR WI---PDCPLGCSDSCVYTGICY--DE A_0025_160 MKLSMMFILSLVLTLSMTDGFILRAEKGGRALRKRRPYSMDLQTR WI---PDCSMGCSHSCVYTGICY--DE A_1387_024 MKLSMMFILSLVLTLSMTDGFIRRAEKGGRTLRQRRPYSMDLQTR LI---PPSCAGCPRSCVYTGICD--DE ermineusAXL95362 MKLSMMFILSLVLTLSMTDGFILRAEKGGRALRKRRPYSMDLQTR WI---PDCSMGCSHSCVYTGICY--DE [Cerm Superfamily 03-2] [Framework XIV] [ /-------Signal-----/------Pro---------/ /--------C---C---C-----C--------/---Post-] V_1278_099 M-MSVMLIVSLVLTLSFTDGINFPGSKAFPRSDTATSRR VRQAAALSACTFECKSGICDVDNTCVPPKDVNTGRRSTPHMK A_0875_017 M-MSVMLIVSLVLTLSFTDGINFPGSKAFPRSDTATSRR VRQAAALLNCASQCPSGICDVDNKCVPPKEVNTGRRSTPHMK A_0039_198 M-MSVMLIVSLVLTLSFTDGINFPGSKAFPRSDTATSRQ VRQAAALSNCAIQCASGICNVSNECVPPEEVNTGRRSTPHMK A_0025_110 M-MSVMLIVSLVLTLSFTDGINFPGSKAFPRSDTATSRQ VRQAAALSNCAIQCASGICNVSNECVPPKEVNTGRRSTPHMK [Cerm Superfamily 03-3] [Framework XIV] [ /-------Signal--------/----------Pro------------//C---C----C-----C-------------------------] V_CG13_037 MKMSVTLIVLLVLGLSFPDGAIPRNINGREASGLHKRDAMVRLIL-RGK CSDRCPSGVCNVTGTCKD------------------------ V_1302_011 MKMSVTLIVLLVLGLSFPDGAIPRNINGREASGLHKRDAMVRLIL-RGK CSDRCPSGVCNVTGTCKD------------------------ V_1258_022 MKMSVTLIVLLVLGLSFPDGAIPRNINGREASGLHKRDAMVRLIL-RGK CSDRCPSGVCNVTGTCKD------------------------ V_1258_023 MKMSVTLIVLLVLGLSFPDGAILRNINGREASGLHKRDAMVRLIL-RGK CSDRCPSGVCNVTGTCKD------------------------ A_0885_056 MKMSVTLIVLLVLGLSLPDGAILRNIDGREASGLHKRDAMVRLIL-RGK CSDRCPSGVCNVTGTCKD------------------------ A_0055_055 VKMSVTLIVLLVLGLSFPDGAILRNIDGREASGLHKRDAMVRLIL-RGK CGDRCPSGVCNVTGTCKD------------------------ A_0520_078 MKMSVTLIVLLVLGLSFPDGAILRNIDGREASGLHKRDAMVRLIL-RGK CSDRCPSGVCNVTGTCKD------------------------ A_0239_138 MKMSVTLIVLLVLDLSFPDGAILRNIDGREASGLRKRGAMVQLILKTGK CSDRCPSGVCNVTGTCKD------------------------ A_0875_064 MKMSVTLIVLLVVGLSFPDGAILRNIDGREASGLRKRGAMVRLIL-RGK CSDRCPSGVCNVTGTCKE------------------------ A_0855_096 MKMSVTLIVLLVVGLSFPDGAILRNIDGREASGLHKRDAMVRLIL-RGK CSDRCPSGVCNVTGTCKE------------------------ A_1387_052 MKMSVTLIV-LVLGLSFPDGAILRNIDGREASGLHKRDAMVRLIL-RGK CSDRCPSGVCNVTGTCKE------------------------ A_0048_330 MKMSVTLIVLLVLGLSFPDGAILRNIDGREASGLHKRDAMVRLIL-RGK CSDRCPSGVCNVTGTCKN------------------------ A_0039_058 MKMSVTLIVLLVLGLSLPDGAILRNIDGREASGLHKRDAMVRLIL-RGK CSDRCPSGVCNVTGTCKN------------------------ A_0025_196 MKMSVTLIVLLVLGLSLPDGAILRNINGREASGLHKRDAMVRLIL-RGK CSDRCPSGVCNVSGTCKN------------------------ A_0031_069 MKMSVTLIVLLVLGLSFPDGAILRNINGREASGLRKRGAMVQLILKRGK CSDRCPSGVCNVTGTCKN------------------------ V_CG13_036 MKMSVTLIVLLVLGLSFPDGAIPRNINGREASGLHKRDAMVRLIL-RGK CSDRCPSGVCNVTGTCKV------------------------ A_0885_055 MKMSVTLIVLLVLGLSLPDGAILRNIDGREASGLHKRDAMVRLIL-RGK CSDRCPSGVCNVTGTCKV------------------------ A_0875_065 MKMSVTLIVLLVVGLSFPDGAILRNIDGREASGLRKRGAMVRLIL-RGK CSDRCPSGVCNVTGTCKVSDGSTCGNRNDRNQCDDKDL---- A_0520_077 MKMSVTLIVLLVLGLSFPDGAILRNIDGREASGLHKRDAMVRLIL-RGK CSDRCPSGVCNVTGTCKVSDGSTCGNRNDRNQCDDKDLGRGT A_0025_197 MKMSVTLIVLLVLGLSLPDGAILRNINGREASGLHKRDAMVRLIL-RGK CSDRCPSGVCNVSGTCKVSDGSTCGNRNDRNQCDDKDLGRGT A_0031_066 MKMSVTLIVLLVLGLSFPDGAILRNINGREASGLRKRGAMVQLILKRGK CSDRCPSGVCNVTGTCKVSDGSTCGNRNDRNQCDDKDLGRGT A_0239_140 -----------------PDGAILRNIDGREASGLRKRGAMVQLILKTGK CSDRCPSGVCNVTGTCKVSDGSTCENRNDRNQCDDKDLGRGT A_0855_095 MKMSVTLIVLLVLGLSLPDGAILRNIDGREASGLRKRGAMVQLILKRGK CGDRCPSKKCNVDMTCMD------------------------ A_0875_062 MKMSVTLIVLLVLGLSLPDGAILRNIDGREASGLRKRGAMVQLILKRGK CGDRCPSKKCNVDMTCMD------------------------ A_0039_059 MKMSVTLIVLLVLGLSLPDGAILRNIDGREASGLRKRGAMVQLILKRGK CGDRCPSKKCNVDMTCMD------------------------ A_0025_006 ------LIVLLVLGLSLPDGAILRNIDGREASGLRKRGAMVQLILKRGK CGDRCPSKKCNVDMTCVD------------------------ A_1387_053 MKMSVTLIVLLVLGLSFPDGAILRNIDGREASGLRKRGAMVQLILKRGK CGDRCPSKKCNIDQTCKD------------------------ A_0039_136 ------------LGLSLPDGAILRNIDGREASGLHNPDAMVQLILKAVP CVGDCEP--CPLTRNCKDQ----------------------- A_0031_068 MKMSVTLIVLLVLGLSFPDGAILRNIDGREASGLRKRGAMVQLILKRGE CGDRCPKNKCNIDMTCKD------------------------ A_0239_137 MKMSVTLIVLLVLGLSLPDGAILRNIDGREASGLRKRGAMVQLILKTGN CGDRCPSTKCNIDKTCKD------------------------ A_0875_066 MKMSVTLIVLLVLGLSLPDGAILRNIDGREASGLRKRGAMVQLILKRGR CGSACPPEKCTMQCTPKD------------------------ A_0239_139 MKMSVTLIVLLVLDLSFPDGAILRNIDGREASGLRKRGAMVQLILKRGR CGSACPPKNCTMQCTPKD------------------------ A_0875_063 MKMSVTLIVLLVVGLSFPDGAILRNIDGREASGLRKRGAMVRLIL-RGR CGTACSPGKCTMQCTPKD------------------------ A_0031_067 MKMSVTLIVLLVLGLSFPDGAILRNIDGREASGLRKRGAMVQLILKRGR CSVACSPGKCTMQCTPKD------------------------ ermineusAXL95561 MKMSVTLIVLLVVGLSFPDGAILRNIDGREASGLRKRGAMVQLILKRGK CGDRCPSKKCNVDMTCMD------------------------ [Cerm Superfamily 03-4] [Framework XIV] [ /-------Signal------/------------Pro------------/ /--C-----C-----C------C-----------] A_0055_052 MKLSVTFTALLLLTITLSHDFILRAIDGREDLGPDDLRAM-DPHKHEIR ALWCP-EWPCSRGQYCNVEEQTCKNYQM------- A_0855_125 MKLSVTFTALLLLTITLSLDFILRAIDGREDLGPDDLRAM-DPHKHEIR ALPCP-EWPCSRGQYCNVEEQTCKNYQM------- A_0048_038 MKLSVTFTALLLLTITLSHDFILRAIDGREDLGPDDLRAM-DPHKHEIR ALPCP-EWPCSRGQYCDVEEQRCKNY--------- A_0520_184 MKLSVTFTALLLLTITLSHDFILRAIDGREDLGPDDLRAM-DPHKHEIR ALRCP-EWPCSRGQYCDVEEQRCKNY--------- A_0025_179 MKLSVTFTALLLLTITLSHDFILRAIDGREDLGPDDLRAM-DPHKHEIR SRRCP-EWPCSRGQYCDVEEQRCKNY--------- A_1387_027 MKLSVTFTALLLLTITLSHDFILRAIDGREDLGPDDLRAM-DPHKHEMR ARRCP-EWSCSRGQYCDVEEQRCKNYEM------- [ /-------Signal-----/--------------Pro-------------/ /C-----C-----C------C-----------] A_0048_039 MKVTVTFIALLMLTTTFSHGFILRAFDGREDLGGWDNSHVANRQDY----- --------------------------------- A_0855_126 MKVTVTFIALLMLTTTFSHGFILRAFDGREDLGGWDNSHVANRQDYQ---- --------------------------------- A_0239_346 MKVTVTFIALLMLTTTFSHGFILRAFDGREDLGGWDNSHVANRQDYQIQRG MCS--SICPLGFICDTGTRSCQPSSIMLN---- A_0055_116 MKVTVTFIALLMLTTTFSHGFILRAFDGREDLGGWDNSHVANRQDYQIQRR ACS--RNCPSHFICNMETG-------------- V_1258_155 -KVTVTFIALLMLTSTFSHGFILRAFDGGEQLGGWGNSLVENRQDYQIQRR ECS--RPCPQYHICNKDTGVCRPPVMM------ V_1302_142 MKVTVTFIALLMLTTTFSHGFILRAFDGGEQLGGWGNSLVENRQDYQIQRR QCS-SRSCPPHYICNKDTGVCRPPVIMRNVDSE V_CG13_114 MKVTVTFIALLMLTTTFSHGFILRAFDGGEQLGGWGNSLVENRQDYQIQRR ECS--RPCPQYHICNKDTGVCRPPVMMRNVDSE A_0039_183 MKVTVTFIALLMLTTTFSHGFILRAFDGREDLGGWDNSHVANRQDYQIQRR VCN--RICPLGFICNTETGICRPSVLM------ A_0055_117 MKVTVTFIALLMLTTTFSHGFILRAFDGREDLGGWDNSHVANRQDYQIQRR VCN--RICPLGFICNTETGICRPSVLM------ A_0025_320 MKVTVTFIALLMLTTTFSHGFILRAFDGREDLGGWDNSHVANRQDYRIPRL VCN--PICKMGDICETDTGICRPSVMM------ ermineusAXL95469 MKVTVTFIALLMLTTTFSHGFILRAFDGREDLGGWDNSHVANRQDYRIPRL VCN--PICKMGDICETDTGICRPSVMM------ [Cerm Superfamily 03-5] [Framework XIV] [ /------Signal------/-------------Pro-------------/ /----C---C---C--C-] A_0055_383 MKLSVMFIVFLMLTMPMTGAGISHRAVNGGEAGVLAGDRA---------- ------------------ V_1278_198 MKLSVMFIVFLMLTMPVTDAVSTRRAVNGGEADVLAGD------------ ------------------ V_1258_078 MKLSVMFIVFLMLTMPVTDAVSTRRAVNGGEADVLAGDRAANLMALLQER Q----CPPSCYPSCRLCK K_0010_200 MKLSVMFIVFLILTMPMTGAGISHRAVNGGEAGVLAGDRAANLMALLQER Q----CSKHC-TTCRVC- K_0010_254 MKLSVMFIVFLMLTMPMTGAGISHRAVNGGEAGVLAGDRAANLMALLQER Q----CSKHC-PTCRVC- K_0010_234 MKLSVVFIVFLMLTMPMTGAGISNRAVNGGEDGVLAGDRAANLIALLQER Q----CRKPC-PPCRVC- K_0010_235 MKLSVMFIVFLMLTMPVTDAVSTRRAVNGGEADVLAGDRASNLMALLQER Q----CPTSCYPNCKNCS K_0010_236 ----VMFIVFMMLTMPMTGAGISHSAVNGGEAGVLAGDRAANLMALLQER Q----CSKHC-PTCRVC- K_0010_237 MKLSVMFIVFLMLTMPVTDAVSTRRAVNGGEAGVLAGDRAANLMALLQER Q----CSKHC-PTCRGC- K_0010_201 MKLSVMFIVFLILTMPMTGACITHLAVNWGEAGVLAGDRAANLMALLQER Q----CSKHC-TTCRVC- K_0010_207 MKLSVIFIVFLMPTMPMTGAGISNRAVNGGEEGVLEGDRAANL------- ------------------ K_0010_239 MKLSVMFIVFLMLTMPVTDAVSTRRAVNGGEADVLAGDRASNLMALLQER L----CPPSCYPSCSLCK litteratusABC74975 MKLSVMFIVFLMLTMPMTCAGISRSATNGGEADVRAHDKAANLMALLQER MRPPLCKPSC-TNCG--- [Cerm Superfamily 03-6] [Framework XIV] [ /------Signal------/----------Pro-----------/ /--C---C--C----C----] A_0855_122 MQSSVMLVVLLMLTMPLINGFIPKTATRRKDFVPNDRSDLDSQIG KRPCPAGCKSCPNGGCVPA- A_0855_123 MQSSVMLVVLLMLTMPLINGFIPKTATRRKDFVPNDRSDLDSQIG KRRCYASCTSCVNGDCIR-- A_0855_124 MQSSVMLVVLLMLTMPLINGFIPKTATRRKDFVPNDRSDLDSQTG KRHCPAGCASCTNGICDLA- V_CG13_061 MQPSVMLVVL-MLTMPLINGFIPKTATRRKDFVPNDRSDLDSQIG KRRCPSACRSCPNGSCIPAG- V_1302_079 MQPSVMLVVL-MLTMPLINGFIPKTATRRKDFVPNDRSDLDSQIG KRRCPSVCRSCPNGSCIPAG- V_1258_005 MQPSVMLVVL-MLTMPLINGFIPKTATRRKDFVPNDRSDLDSQIG KRRCPSVCRSCPNGNCIPAG- A_0885_024 MQSSVMLVVLLMLTMPLINGFILKAAGGRKDFVPNDRSDLDSQIR NPRCPGACRSCPNGGCVPAG A_0875_049 MQLSVMLVVLLMLTMPLINGFILKAAGGRKDFVPNDRSDLDSQIG KRRCYASCTSCVNGDCIR-- A_0055_122 MQSSVMLVVLLMLTMPLINGFIPKTATRRKDFVPNDRSDLDSQIG KRRCYASCTSCVNGDCIR-- A_0055_123 MQSSVMLVVLLMLTMPLINGFIPKTATRRKDFVPNDRSDLDSQIG KRRCPSGCKSCPNGGCVPA- A_0055_124 MQPSVMLVVLLMLTMPLINGFILKAPGGRKVFVPNDRSDLDSQIQ KPHCLPSCASCTNGICDMA- A_0520_202 MQSSVMLVVLLMLTMPLINGFILKAAGGRKVFVPNDRSDLDSQIR KPHCLPSCASCANGICDMA- A_0520_201 MQSSVMLVVLLMLTMPLINGFILKAAGGRKDFVPNDRSDLDFQIG KRRCPGACRSCDNGICVPAG A_0025_332 MQSSVMLVVLLMLTMPLINGFIIKAAGGRNDFVPNDRSDLDFQIG KRRCPGGCRSCDNGICVPAG A_0025_331 MQSSVMLVVLLMLTMPLINGFIPKTATRRKDFVPNDRSDLDFQIG KRRCPAACSSCPNGGCIPAR A_0239_036 MQSSVMLVVLLMLTMPLINGFIPKTATRRKDFVPNDRSDLDSQIR NPRCPSACRSCPNGSCVPTR A_0031_453 MQSSVMLVVLLMLTMPLINGFIPKTATRRKDFVPNDRSDLDSQIR NPRCPSACRSCPNGSCVPTR A_1387_050 MQPSVMLVVLLMLTMPLINGFIPKTATRRKDFVPNDRSDLDSQIQ IPQCPPSCASCTNGICDMA- A_0520_200 MQSSVMLVVLLMLTMPLINGFIPKTATRRKDFVPNDRSDLDSQIG KRRCYASCTSCVNGDCIR-- A_0048_124 MQSSVMLVVLLMLTMPLINGFIPKTATGRKDFVPNDRSDLDSQIG KRRCYASCTSCANGDCIR-- A_1387_051 MQPSVMLVVLLMLTMPLINGFIPKTATRRKDFVPNDRSDLDSQIG KRRCPSGCSSCPNGGCIPAG [Cerm Superfamily 03-7] [Formerly Cerm_05 in Abalde et al. 2018 GBE 10:2643–2662] [Framework XIV] [ /------Signal------/---------Propre---------/ /------C--C---C-----C-] A_0855_138 MNFSVMFILALVLTLSMTDAFILPAENGGRTFRQHSSDSMDLKTR QIETRNLCPQCPKGCHVNKSCIE A_0855_139 MNFSVMFILALVLTLSMTDAFSLLAENGGRTFRQHSSDSMDLKTR QIETRNLCPQCPDGCHMDLTCKG V_CG13_147 MNFSVVFIFALVLTLSMTDAFIRPAENGGRTFRQRSPDSMDLKTR QIKTRNPCPNCPNGCHMDMTCIN V_CG13_148 MNFSVMFILALVLTLSMTDAFIRPAENGGRTFPQHSPDSMDLKTR QIETRNLCPNCPKGCHVDRTCIE V_CG13_149 MNFSVVFIFALVLTLSMTDAFIRPAENGGRTFRQRSPDSMDLKTR QIKTRNPCPNCPNGCHMDMTCIE V_1302_023 MNFSVVFIFALVLTLSMTDAFIRPAENGGRTFRQRSPDSMDLKTR QIKTRNPCPNCPNGCHMDMTCIE V_1302_024 MNFSVVFIFALVLTLSMTDAFIRPAENGGRTFRQRSPDSMDLKTR QIKTRNPCPNCPNGCHMDMTCIN V_1258_153 MNFSVVFIFALVLTLSMTDAFIRPAENGGRTFPQHSPDSMDLKTR QIETRNLCPNCPKGCHIDRTCIE A_0885_146 MNFSVMFILALVLTLSMTDAFILPAENGGRTFRQHSSDSMDLKTR QIETRNLCPQCPKGCHVNKSCIE A_0875_022 MNFSVMFILALVLTLSMTDAFSLLAENGGRTFRQHSSDSMDLKTR QIETRNLCPQCPDGCHMDRTCIE A_0055_212 -----------------------------RTFRQHSSYSLDLKTR QIETRNLCPQCPKGCHVDLTCKE A_0039_005 MNFSVMFILALVLTLSMTDAFILPAENGGRTFRQHSSVSMDLKTR QIETRDLCPQCPKGCHVDRTCIE K_0010_027 MNFSVMFILALVLTLSMIDGLSRPAEKGGRTFRQHTPDSMDLQTR QIKTRSLCPKCPDGCHMDMTCI- A_0025_161 MNFSVMFILALVLTLSMTDAFIRPAKNGGRTFRQHSSDSMDLKTR QIETRNLCPQCPKGCHMNKSCIE A_1387_023 MNFSVMFILALVLTLSMTDAFILPAENGGRTFRQHSSDSMDLKTR QIETRNQCPQCPKGCHMNKSCIE A_0520_265 MNFSVMFILALVLTLSMTDAFSLLAGNGGRTFRQHSSDSMDLKTR QIETRNLCPQCPKGCHVDLTCKE A_0048_222 MNFSVMFILALVLTLSMTDAFSLLAGNGGRTFRQHSSDSLDLKTR QIETRNLCPQCPKGCHVDLTCKE A_0520_263 MNFSVMFILALVLTLSMTDAFILPAENGGRTFRQHSSDSMDLKTR QIETRNLCPQCPKGCHVDLTCKE A_0520_264 MNFSVMFILALVLTLSMTDAFILPAENGGRTFRQHSSDSMDLKTR QIETRNMCPQCPEGCHMDRTCKE V_CG13_345 MNFSVMFILALVLTLSMTDAFIRPAENGGRTFPQHSPDSMDLKTR Q---------------------- A_0031_160 MNFSVMFILALVWTLSMTDAFILPAENGGRTFRQHSSDSMDLKTR Q---------------------- ermineusAXL95576 MNFSVMFILALVLTLSMTDAFILPAENGGRTFRQHSSDSMDLKTR QIETRNLCPQCPKGCHVNKSCIE betulinusAMP44697 MNFSLIFILALVLTLSMSDGFIRRAENGERTFSQHSPDAKDVQTH QINTRNLCPHCPNGCHMDRTCI- praecellensATF27623 MKLSVMFILALVLTLSLTDGFIRRAENGGRTFRQHSSDAVDLQTG QIKTRNICPQCPKYCQVTTVCTP [Cerm Superfamily 04] [Framework XIV] [ /-------Signal------/------------Pro------------/ /-C----C------C----C------/Pt----] A_0855_092 ------------------------DNEGKALGRYDRHVRDLLTHERTKR -DC-NPPCKAPTPYCRGGSC-V-SNGDIQNNYKK A_0055_097 ------------------------VLEGKALGLYDRHVRDLLTHKRTKR -DC-NPPCKAPTPYCWGGSCSV-SNGDIQNNYKK A_0055_098 ------------------------DNEGKALGLYDRHVRDLLTHKRTKR -DC-NPPCKAPTPYCWGGSCSV-SNGDIQNNYKK A_0039_109 ------------------------DNEGKALGLYDRHVRDLLTHKRTKR -DC-NPPCKAPTPYCWGGSCSV-SNGDIQNNYKK A_0039_110 ------------------------VLEGKALGLYDRHVRDLLTHKRTKR -DC-NPPCKAPTPYCWGGSCSV-SNGDIQNNYKK A_0239_352 ------------------GLLLHDDNEGKALGRYDRHVRDMLTHKRTKP -DC-NLPCKAPTPYCRGGSCSV-SNGDIQNNYKK A_0239_353 ------------------------DNEGKALGRYDRHVRDLLTHKRTKR -DC-NPPCKAPTPYCRGGSCSV-SNGDIQNNYKK A_0855_093 MKLSVMVIVLVLAMAFTPGLLLHDDNEGKALGRYDRHVRDLLTHERTKR -DC-NPPCKAPTPYCRGGSCS-TFNKDV----GR V_CG13_007 MKLSVMVIVLVLAMAFTPGLLLHDDNEGKALGRYDRHVRDMLTHKRTKR -DC-NPPCEAPTPYCRGGSCSSTFNKDI----GR A_1387_099 MKLSVMVIVLVLAMAFTPGLLLHDDNEGKALGRYDRHVRDLLTHKRTKR -DC-NPPCEAPTPYCRGGSCSSTFNKDM----GR A_0048_054 MKLSVMVIVLVLAMAFTPGLLLHDDNEGKALGRYDRHVRDLLTHKRTKR -DC-NPPCEAPTPYCRGGSCSSTFNKDA----GR A_0055_096 MKLSVMVIVLVLAMAFTPGLLLHDDNEGKALGLYDRHVRDLLTHKRTKR -DC-NPPCKAPTPYCWGGSCSATFNNFL----GR A_0039_111 MKLSVMVIVLVLAMAFTPGLLLHDDNEGKALGLYDRHVRDLLTHKRTKR -DC-NPPCKAPTPYCWGGSCSATFNNFL----GR A_0031_109 MKLSVMVIVLVLAMA-TPGLLLHDDNEGKALGLYDRHMRDLLTHKRTKR -DC-NPPCKAPTPYCRGGSCSATVNNFL----GR A_0031_108 MKLSVMVIVLVLAMA-TPGLLLHDDNEGKALGRYDRHVRDMLTHKRTKP -DC-NLPCKAPTPYCRGGSCSATVNNFL----GR A_0239_351 MKLSVMVIVLVLAMAFTPGLLLHDDNEGKALGLYDRHVRDLLTHKRTKR -DC-NPPCKAPTPYCRGGSCSTTVNNFL----GR A_0520_262 MKLSMMVIVLVLAMAFTPGLLLHDDNEGKALGLYDRHVRDLLTRKRTKR -DC-NPPCEAPTPYCWGGRCSSTINNFV----GR A_1387_098 MKLSVMVIVLVLAMAFTPGLLLHDDNEGKALGRYDRHVRDLLTHKRTKR -DC-NPPCEAPTPYCRGGSCSSSFNKDI----GG A_0885_103 MKLSVMVIVLVLAMAFTPGLLLHDDNEGKALGRYDRHVRDLLTHKRTKR -DC-NPPCEAPTPYCIGGSCSS-FNKDM----GR A_0875_002 MKLSVMVIVLVLAMAFTPGLLLHDDNEGKALGRYDRHVRDLLTHKRTKR -DC-NPPCEAPTPYCIGGSCSS-FNKDM----GR A_0239_354 ------------------GLLLHDDNEGKALGRYDRHVRDMLTHKRTKP -DC-NPPCKAPTPYCRGGSCSS-FNKDM----GG V_1302_084 MKLSVMVIVLVLAMAFTPGLLLHDDNEGKALGRHVR---DTLVDKRVKR SSC-NPSCSLPD-ICRNGACEP-FRQDL----GR V_1278_056 MKLSVMVIVLVLAMAFTPGLLLHDDNEGKALGRHDRHVRDTLVDKRVKR SSC-NPSCSQPY-HCNDGVCVL-FNGDL----GR V_1258_061 MKLSVMVIVLVLAMAFTPGLLLHDDNEGKALGRHVR---DTLVDKRVKR SSC-NPSCSLPD-ICRNGACVP-FRQDL----GR V_1258_062 MKLSVMVIVLVLAMAFTPGLLLHDDNEGKALGRHDRHVRDTLVDKRVKR SSC-NPSCSPPN-VCKNGACVR-FNSDL----GR A_0520_260 MKLSMMVIVLVLAMAFTPGLLLHDDNEGKALGRYDRHVRDLLTHEGTKR -DC-NPPCEAPTPYCRGGSCST-FNSDM----GR A_0025_279 MKLSVMVIVLVLAMAFTPGLLLHDDNEGKALGRYDRHVRDLLTHEGTKR -DC-SPPCAAPTPYCRGGSCYA-FNKDV----GR A_0025_280 MKLSVMVIVLVLAMAFTPGLLLHDDNEGKALGRYDRHVRDLLTHEGTKR -DC-NPPCAAPTPYCRGGSCYA-FNKDV----GR ermineusAXL95483 MKLSVMVIVLVLAMAFTPGLLLHDDNEGKALGRYDRHVRDLLTHEGTKR -DC-NPPCAAPTPYCRGGSCYA-FNKDV----GR betulinusAMP44689 MKLSVMVIVLVLATAFTPGLLLHDDNEGKALRRHVRHVRDTLADERAKR SSC-NPPCIPPK-ICRLDVCDN-YNSDM----GR [Cerm Superfamily 06] [Framework XIV] [ /----Signal----/---------------------Pro-------------------/ /----------------C---C------------------C---C----------/--Pos--] V_1258_151 MKVVVILLAALVAASAA-PQKRFFITDIQNWIHQLQA-VFNKAKDKFNELTSGLGVHFDR IVDLLIDQIDSGMTEAACIKVCETSATKILGDASSMAGTVCAPVCTAALAKLEEVAG------- A_0039_001 MKVVVVLLAVLVAASAA-PQKRFFVQDIQNWIHQLQA-AFNKAKDKFNELTSGLGVHFDR IVDLLIDQIDSGMTEAACIKVCETSSTKILGNASSMAGMVCAPVCTAALAKLEEVAG------- ermineusAXL95596 MKVVVVLLAVLVAASAA-PQKRFFIQDIQNWIHQLQA-AFNKAKDKFNELTAGLGVHFDR IVDLLIDQIDSGMTEATCIKVCETSSSKILGDASYMADSVCAPVCTAALAKLEEVAG------- betulinusAMP44690 MKVVVVLLAVLVAASAA-PQKRFFIEDIKNWIHQLQA-VFNQAKDKFNELTSGLGVHFDR IVDLLIDQIDSGMTEAACIKVCESSATKILGDASSMAGTVCAPVCTAALAKLEEVAG------- magusDAC80612 MKVVVVLLAVLVAASAA-PQKRFFVKDIQDWIYQIQA-VFNKAKDKFNELTSGLGVHFNR IVDMLIDQIDSGMSEATCIHVCESSANTLLGPASSLADSVCAPVCTAALAKLEEIAG------- californicusADB93098 MKVAVVLLVSLLAVTYALPEKRIFFGGIVDKVKDTFTKIFNKAKETFDKITDGFDVDFDE VVDKLIAQIHSTPTKAACKAACKKGAKLILKAAAPLASQVCGPACNAALAKLEKIADDINDDDD [Cerm Superfamily 08] [Framework VIII] [ /--------Signal-------/ /-------C-------C------------C-C-----C---------------------C--------C------------------C-C---------------C/P] A_0239_147 -------MMLFIFAAIIFTMAST TVTAE--RCAS-RKSVCAW---EVLG-KTCSCPDPYSCSQRYHYKAELTVRVGKLSFYTCQMIAAFRRCTPRSRPAMELDAKLKQLNCRCLSGIYKRVN---DTVVCG- A_0031_165 MKKARLTMMLFIFAAIIFTMAST TVTGE--RCAS-RKSVCAW---EVLG-KTCSCPDPYSCSQRYHYKAELTVRLGKLSFYTCQMIAAFPRCTPWSGPAMELDAKLKQLNCRCLSGIYKRVN---DTVVCG- A_0855_056 -------MMLFMFAAIIFTMAST TVTEN--MCANGAQSVCAW---KTLG-ETCRCPAPYSCSQERYYKAELTTRFGKLSFYTCQMNVAFPRCR--SGHAMT--ANLKQLNCKCPSGIYKRVN---RVVVCG- A_0039_047 -------MMLFIFAAIIFTMALT TVTAE--MCANGAQSVCAW---KTLG-ETCRCPAPYSCSRARYYKAELTTRFGKLTFYTCEMNAGFPRCR--SGPAMT--ANLKKLNCKCPSGIYKRVN---RVVVCG- andremeneziATF27507 -------MMLFMFAAIIFTMAST TVTAE--TCTS-DKRVCAW---QGQN-DTCSCSNSNSCTRDDAHKVVVTMTQGGQSFFTCKKISDFSACDG-SQSVMN--SGMSQLNCRCSGDTYKIEN---GVVVCG- - A_0055_017 -------MMLFMFAAIIFTMALT TVTAE--MCENGGRSVCAW---KGLG-EMCICPDPYSCVQSDAYKAVVTLENRTETFYTCQQISRFSLCAA-SDPALQ--GQLQQLKCRCSNDIYVLGV---GAIVCG- A_0031_163 -------MVLFIFAAIIFTMALT TVTAE--MCENGGRSVCAW---KGLG-EMCICPDPYSCVQSDAYKAVVTLENRTETFYTCQQISRFSLCAA-SDPALQ--GQLQQLKCRCSNDIYVLGV---GAIVCG- A_0031_166 MKKARLTMMLFIFAAIIFTMAST TVTGE--MCENGGRSVCAW---KGLG-EMCICPDPYSCVQSDAYKAVVTLENRTETFYTCQQISRFSLCAA-SDPALQ--GQLQQLKCRCSNDIYVLGV---GAIVCG- A_0031_169 -------MMLFIFAAIIFTMAST TVTAE--MCENGGRSVCAW---KGLG-EMCICPDPYSCVQSDAYKAVVTLENRTETFYTCQQISRFSLCAA-SDPALQ--GQLQQLKCRCSNDIYVLGV---GAIVCG- A_0855_058 MRKARLTMMLFMFAAIIFTMAST TVTEE--MCENGGQSVCAW---KGLG-EMCSCPDPYSCVQSDAYKGEVTLERSTQTFYTCQKISVFSLCAA-SDPAME--GQLQQLNCRCSNGIYVLGV---GAIVCG- A_0520_230 -------MMLFIFAAIIFTMAST TVTGD--MCENGGRSVCAW---KSLG-EMCTCPDPYSCVQSDAYKAEV--ENGTETFYTCQQISRFSLCNA-SDLAMQ--GQLKQLKCRCSNGIYVFGV---FAILCG- A_0885_113 -------MMLFIFAAIIFTMAST TVTGD--MCENGGRSVCAW---KSVG-EMCTCPDPYSCVQSDAYKAEV--ENGTETFYTCQQISRFSLCNA-SDVAMQ--GQLKQLKCRCSNGTYVFRT---FAISCG- A_1387_225 -------MMLFIFAAIIFTMALT TVTED--MCENGGRSVCAW---KGLG-EMCSCPDPYSCVQSDAYKAEVTLEYGTGTFYTCQQISRFSLCNA-SDPAMQ--GQLQQLNCRCSNGIYVLGV---GAIVCG- A_0025_380 -------MMLFIFAAIIFTMAST TVIED--MCENGGQSVCAW---KGMG-EMCICPDPYSCVQSDAYKAEVTLVNRTETFYTCQQISDFSLCAA-SDPAMQ--GQLQQLNCRCSNGIYVLGV---GAIVCG- ermineusAXL95456 -------MMLFMFAAIIFTMAST TVIED--MCENGGQSVCAW---KGMG-EMCICPDPYSCVQSDAYKAEVTLVNRTETFYTCQQISDFSLCAA-SDPAMQ--GQLQQLNCRCSNGIYVLGV---GAIVCG- V_CG13_050 -------MMLFMFAAIIFTMAST TVTAD--TCAS-DQSVCAY---AGVG-ASCNCPGSNPCTQDDDHKVEVTLDEGSTSLYICQQISDFGECVG-SEVAMDSGL--SQLNCKCSSGTYTT-S-QSLDVVCG- V_1302_046 -------MMLFMFAAIIFITTST TVTAD--TCAS-DQSVCAY---AGLG-VSCNCPGSNPCTQDDAHKVEVTLQQASMSLYICQQISDVDECAE-SAVAMDAEL--TQLNCKCSSGTYTTTS-QSLDVVCG- V_CG13_048 -------MMLFMFAAVIFITTST TVTAD--TCAS-DQSMCAY---TGLAELSCNCPGSNPCTQDDDHKVELTVGQESISLYICQQISDVDECAK-SAAAMDAEL--TQLNCRCSSGIYTIAQEEEFTVVCG- V_1278_003 -------MMLFMFAAVIFITTST TVTAD--TCAS-DQSMCAY---TGLAELSCNCPGSNPCTQDDDHKVELTVGQESISLYICQQISDVDECAK-SAAAMDAGL--TQLNCRCSSGIYTIAQ-EEFTVVCG- A_1387_227 -------MMLFMFAAIIFTMAST TVTAN--MCAS-DQSVCAY---VG--EAVCNCPGSNRCTQDDAHKVEVTLQQDSMTMHICQEISEFNECVG-PETAMGAEL--NQLNCKCSSGTYTTKQ--GLNVVCG- A_1387_228 -------MMLFMFAAVIFTMAST TVSEDDETCAN-DQSVCAF---EGLVQQFCNCPGSNRCTQDDAHKVEVTLQQESMSLYICQKISEIHECAE-SEAPMDFRL-LNQLNCTCSSGTYNTTQ--DLAVVCG- A_0039_046 ------------------TMAST TVSEDFDTCAS-VQSVCAL---ASLDQQLCNCTGSNSCTQDDAHKVEVTLQQDIFSLYICQEISEIHECAE-SEAPMDFLL-LNQLYCTCSSGTYNTTQ--DLTVVCG- A_0055_018 -------MMLFMFAAIIFTMAST TVSED-ETCAN-DQSVCAYHY-AGADEALCDCPGSDSCIQDNDHEVVVTTGGASMSLHICQEISAFNECDG-SEAAMDAEL--SQLNCTCSSGTYITEQ-GGLNVVCG- V_1302_045 -------MMLFMFAAIIFTMAST TVSVI-PECPS-DQSVCLW---LGLG-EICSCSGSNSCIQDDAHKFEVALGGRNHSIYTCQQISAFRACAV-SEAAMVANY--TQLICRCPEDTYKFEG---PTIVCG- caracterB0L0Y6 -------MKLFMFAAIIFTMAST TVRAE--QCAN-NRKVCTW---DGQGDTNCDCIG-TACHEDDAHKVSV----AGSAFYTCQPISAFRVCDG-SEDVMDAGF--SELYCRCSGGSYTISN---GEVVCD- A_0025_118 -------MMLFMFAAIIFTMASR TVTDN--TCAH-NKKACAMVL-GDYVDIHCDCASTGNCIIHPAHKIAV---NDGTLFYTCQLISDFNICKG-SEPVMDAGL--TQLNCRCPNGAYKYEG---SAVVCS- A_0875_019 -------MMLFMFAAIIFTMASR TVTDN--TCAH-NMKVCTMVM-GDFVEKRCDCASNGKCIIHPAHKITV---NDGTLFYTCQQISGFRICEG-PEPVMDAEY--TQLHCRCPNSAYKFED---NTILCS- A_0031_168 -------MMLFMFAAIIFTMASR TVTDN--TCAH-NKKACAMVL-RGYVDIHCDCASTGSCTIHPAHKITV---NDGTLFYTCQLISDFNICEG-SEPVMDAGF--TQLNCRCPNGAYKYEG---RAVVCS- ermineusAXL95466 -------MKLFMFTAIIFTMAST TVTET--TCEN-DKKACGMVL-GNLRDTHCDCASTGNCIFHPAHKITV----DDTLFYTCRKNSDFDICDG-SQPVMNAAL--TQLNCRCPGAAYTFEG---SDVICG- V_CG13_049 -------MMLFMFAAIIFTMAST TVTAI--TCQL-ETDLCAIEIDSNLT-EICTCTD-GGCTRDESHTFSV----DTISMVTCQQISEFDDCDA-DQALVDDNF--TQVYCKCPGYNYRAGG--TQGIVCG- V_1302_044 -------MMLFMFAAIIFTMAST TVTAI--TCEL-ETDLCAIEIDSDFT-EICTCAD-GGCTRDESHTLSV----DTISMVTCQQISEFDDCDA-DQALVDDNF--TQIYCKCPNNNYRAGG--TQGIVCG- A_0039_048 -------MMLFIFAAIIFTMAST TVTAI--SCEQ-ETDLCAIETDSNLT-EICTCTD-GGCTRDGSHTLSV----SGISFVTCQQISDFDDCIT-DQVLVDDNF--TQVYCKCPGDNYQVGG--TQGIVCG- A_0031_164 -------MMLFMFAAIIFTMAST TVTAI--SCEQ-ETDLCAIETDSNLT-EICTCTD-GGCTRDGSHTLSV----SGISFVTCQQISDFDDCIT-DQVLVDDNF--TQVYCKCPGDNYQVGG--TQGIVCG- A_0239_148 MKKARLTMMLFIFAAIIFTMAST TVVAI--SCEQ-ETDLCAIEIDSNLT-EICTCTD-GGCTRDDSHTLSV----SSISFVTCQPLSDFDDCFA-DQALVDDDF--TQIYCKCPGDNYTVGG--TQGIVCGY A_1387_226 -------MMLFMFAAIIFTMAST TVTAI--SCEL-ETDLCAIEIGSDLT-EICTCTD-GGCTRDDSHTLSV----SDISLVTCQLISDFDDCTA-GQALVDDNF--TQVYCKCPGDNYRIKG--TQGIGCD- ermineusAXL95570 -------MKLFMFTAIIFTMAST TVTAR--TCRN-NMEVCAIQY-DEMY-DYCSCSN-GGCIKDDPYKVAV----PGMSVFTCQQISDFNICGQ-SQFVMKDPA--YQINCRCRDGRYKVVH---GGIKCE- [Cerm Superfamily 10] [Framework VI/VII] [ /-----Signal-----------/----Pro----/ /----------------C------C--------CC----C----C-] V_1258_164 MKSTLFLTVLMAAVFLTFFTETDTTSIF--KAREKR ---------A-DSEEFPCAGTFADCRGQPNGTVCCD----------- A_0048_010 MKSTLFLTVLMAAVFLTFFTETDTTSIF--KAREKR ---------S-DSEEFPCAGTFADCRGQPNGTTCCDTGACHGEVCYY A_0055_215 MKSTLFLTVLMAAVFLTFFTETDTTSIF--KAREKR ---------S-DSEEFPCAGTFADCRGQPNGTTCCDTGACYGEVCYY A_0039_008 MKSTLFLTVLMAAVFLTFFTETDTTSIF--KAREKR ---------S-DSEEFPCAGTFADCRGQPNGTTCCDTGACYGEVCYY A_0885_007 MKSTLFLTVLMAAVFLTFFTETDTTSIF--KAREKR ---------S-DSEEFPCAGTFADCRGQPNGTTCCDTGACYGEVCYY A_0875_140 MKSTLFLTVLMAAVFLTFFTETDTTSIF--KAREKR ---------S-DSEEFPCAGTFADCRGQPNGTTCCDTGACYGEVCYY A_0855_156 MKSTLFLTVLMAAVFLTFFTETDTTSIF--KAREKR ---------S-DSEEFPCAGTFADCRGQPNGTTCCDTGACYGEVCYY V_CG13_198 MKSTLFLTVLMAAVFLTFFTETDTTSIF--KAREKR ---------A-DSEEFPCAGTFADCRGQPNGTVCCDTGACYGEVCYY V_1302_004 MKSTLFLTVLMAAVFLTFFTETDTTSIF--KAREKR ---------A-DSEEFPCAGTFADCRGQPNGTVCCDTGACYGEVCYY A_1387_356 MKSTLFLTVLMAAVFLTFFTETDTTSIF--KAREKR ---------S-DSEEFPCAGTFADCRGQPNGTTCCDTGACYGEVCYY A_0031_022 MKSTLFLTVLMAAVFLTFFTETDTTSIF--KAREKR ---------S-DSEEFPCAGTFADCRGQPNGTTCCDTGACYGEVCYY ermineusAXL95597 MKSTLFLTVLMAAVFLTFFTETDTTSIF--KAREKR ---------S-DSEEFPCAGTFADCRGQPNGTTCCDTGACYGEVCYY californicusADB93115 MKFPLLFISLALAAFLTRVQDADSSVIS--KEKSVR ---------D--GEEFPCAGTMADCRGLADNSVCCDTGKCIGEVCYY V_CG13_325 ----------------------EAMTSFRTRAKAKR ---------SFEEVREACDGTSADCRGQLNGTPCCRNGHCDEYVC-- A_0855_021 ----------------------EAMTSFRTRAKAKR ---------IPEEVREACDGMPTDCRGQPKGTPCCRNGQCKGGVCYY A_0055_032 MKFTTFVMVLMAAVLLTSILETEAMTSFRTRAKAKR ---------ISEEVREACDGMSTDCRGQPKGTPCCRNGQCRGGVCYY A_0039_011 MKFTTFVMVLMAAVLLTSILETEAMTSFRTRAKAKR ---------ISEEVREACDGMSTDCRGQPKGTPCCRNGQCRGGVCYY A_0025_055 MKFTTFVMVLMAAVLLTSILETEAMTSFRTRAKAER ---------ISEEVREACDGMSTDCRGQPKGTPCCRNGQCRGGVCYY A_0520_043 MKFTTFVMVLMAAVLLTSILETEAMTSFRTRAKAER ---------SFEEMREACEGMSTDCRSQPNGTPCCRNGQCRGYVCYY A_0239_094 MKFTTFVMVLMAAVLLTSILETEAMTSFRTKAKAER ---------SFEEMREACEGMPTDCRSQPNGTPCCRNGQCRGYVCYY A_0031_384 ----------------------EAMTSFRTKAKAER ---------SFEEMREACEGMPTDCRSQPNGTPCCRNGQCRGYVCYY A_0048_079 MKFTTFVMVLMAAVLLTSILETEAMTSFRTRAKAER ---------SFEEFREACEGMSTDCRSQPNGTPCCRNGQCRDYVCYY A_0025_054 MKFTTFVMVLMAAVLLTSILETEAMTSFRTRAKAER ---------SFEEFREACEGMSTDCRSQPNGTPCCRNGQCRDYVCYY A_0031_386 MKFPTFVMVLMAAVLLTSILETEAMTSFRTGAKAKR ---------IP-EVRKACVGTFADCRDQPKGTVCCGNGQCRGGVCYY A_0239_092 MKFTTFVMVLMAAVLLTSILETEAMTSFRTGAKAKR ---------IP-EVRKACVGTFADCRDQPKGTPCCGNGQCKGGVCYY A_0885_122 MKFTTFVMVLMAAVLLTSILETEAMTSFRTREKAKR ---------SLEEVREACEGTFADCRGQPKGTHCCRNGQCEGGVCYY A_0875_048 MKFTTFVMVLMAAVLLTSILETEAMTSFRTREKAKR ---------SLEEVREACEGTFADCRGQPKGTHCCRNGQCEGGVCYY A_0055_033 MKFTTFVMVLMAAVLLTSILETEAMTSFRTRAKAKR ---------SLEEVREACEGTFADCRGQPKGTHCCRNGQCEGGVCYF A_0855_022 MKFTTFVMVLMAAVLLTSILETEAMTSFRTGAKAKR ---------SLEEVREACEGTFADCRGQPKGTPCCRNGQCKGGVCYY V_CG13_064 MKFTTFVMVLMAAVLLTSILETEAMTSFRTRAKAKR ---------SFEEVREACDGTSADCRGQLNGTPCCRNGHCDEYVCYY V_1302_030 MKFTTFVMVLMAAVLLTSILETEAMTSFRTRAKAKR ---------SFEEVREACDGTSADCRGQPNGTPCCRNGQCDEYVCYY V_1258_090 MKFTTFVMVLMAAVLLTSILETEAMTSFRTRAKAKR ---------SFEEVREACDGTSADCRGQPNGTPCCRNGQCDEYVCYY V_1278_008 MKFTTFVMVLMAAVLLTSILETEAMTSFRTRAKAER ---------SFEEVREACGGTFTDCRGQPNGTPCCRNGQCRDYVCYY A_1387_340 MKFTTFVMVLMAAVLLTSILETEAMTSFRTRAKAER ---------SFEEVREACEGTFTDCRGQPKGTPCCRNGQCKGGVCYY A_0885_318 ----------------------EAMTSFRTRAKAKR ---------IPEEVREACDGMSTDCRGQPKGTPCCLNGQCKGGVCYF ermineusAXL95606 MKFTTFVMVLMAAVLLTSILETEAMTSFRTRAKAKR ---------IPEEVREACDGMPTDCRGQPKGTPCCRNGQCKGGVCYF A_0855_023 MKFTTFVMVLMAAVLLTSILETEARRSIRARMKAKK AVEEETLREFPERVEEACEGTSRSCLGKLDGTVCCENGHCRDNACYI A_0039_012 MKFTTFVMVLMAAVLLTSILETEARRSIRARMKAKK AVEEETLREFPERVEEACEGTSRSCLGKLDGTVCCENGHCRDNACYI V_1302_029 MKFTTFVMVLMAAVLLTSILETEARRSIRARMKAKK SVPEETLEEFPERVEEACEGTSRSCRGKPDGTACCENGHCRENACYI A_0055_034 MKFTTFVMVLMAAVLLTRILETEARRSIRARMKAKK AVEEETLREFPERVEEACEGTSRSCRGKPDGTACCENGHCRENACYI A_0239_093 MKFTTFVMVLMAAVLLTRILETEARRSIRARMKAKK AVEEETLREFPERVEEACEGTSRSCRGKPDGTACCENGHCRENACYI A_0031_385 MKFPTFVMVLMAAVLLTSILETEARRSIRARMKAKK AVEEETLREFPERVEEACEGTSRSCRGKPDGTACCENGHCRENACYI K_0010_039 MKFPTFVMVLMAAVLLTSILETEARRLIRARVEAKK SVPHETLNEVSERMEESCEGTFWNCRDQTDGTACCRNGHCYLGVCYV betulinusALM87486 MKYPTFVMVLMAAVLLTGILETEARASLRARLKAKK TVPEQALEEFPERVEEACEGTSWSCVGKPDGTACCRSGHCFNAACYI magusQFQ61137 MKFSTFVMVLMAAVLLTGILETEARRSFTARLKAKR ----FDQDDYLERVEEICEGTNRDCRGQPDGT--------------- [Cerm Superfamily 11] [Framework IX] [ /-----------Signal--------/--Pro-----/ /-------C----C-C-----------C---------C--------------------C------/-P] A_0039_322 ---------VTVALLLTLVMSIDSAPADQTETGRVSLR EDSENTFPCDTGRCACLPKEGSSTSYQCQSINSSTANCVE----------------------------- A_0055_360 ---MEFRRLVTVALLLTLVMSIDSAPADQTETGRVSLR EGMENKFPCHSGSCACLPKKGTSTSYRCKSINTSHAHCFD----------------DECLTKEEWGRRR V_1302_087 ---MEFRRLVTVALLLTLVMSIDSAPADQTETGRVSLR EGLENQFPCNPGRCACLPKDGSSTSYQCQSIQHSTADCFD----------------GECVTEDEWGGRR V_1278_096 ----------------------DSAPADQTETGRVSLR EGLENLFPCNPGRCACLPNDGSSTSYQCQSIQHSTADCFD----------------GECVTEDEWGGRR V_1258_012 ---MEFRRLVT---LLTLVMSIDSAPADQTETGRVSLR EGLENLFPCNPGRCACLPNDGSSTSYQCQSIQHSTADCFD----------------GECVTEDEWGGRR V_CG13_023 ---MEFRRLVTVALLLTLVMSIDSAPADQTETGRVSLR EGLENLFPCNPGRCACLPKEGSSTSYQCQSIQHSTAGCFD----------------GECVTEDEWGGRR A_0039_055 ---MEFRRLVTVALLLTLVMSIDSAPADQTETGRVSLR EDSENTFPCDTGRCACLPKEGSSTSYQCQSINSSTANCVD----------------DKCVTEDEWEGRR A_0031_369 ---MEFRRLVTVALLLTLVMSIDSAPADQTETGRVSLR EDSENTFPCDTGRCACLPKEGSSTSYQCQSINSSTANCVD----------------DKCVTEDEWEGRR A_0520_059 ---MEFRRLVTVALLLTLVMSIDSAPADQTETGRVSLR EDLDNTFPCDTGRCACLPKEGSSTSYQCQSINSSTANCFD----------------DKCVTEDEWGGRR A_0048_226 ---MEFRRLVTVALLLTLVMSIDSAPADQTETGRVSLR EDLDNTFPCDTGRCACLPKEGSSTSYQCQSINSSTANCFD----------------DKCVTEDEWGGRR A_1387_002 ---MEFRRLVTVALLLTLVMSIDSAPADQTETGRVSLR EGLENLFPCNPGTCACLPKEGSSTSYQCQSIDSSPANCFD----------------DECVTEDQWGGRR A_1387_003 ---MEFRRLVTVALLLTLVMSIDSAPADQTETGRVSLR EGLENLFPCNPGTCACLPKEGSSTSYQCQSIDSSPANCFEERTRTRAHGNTRVHCSDECVTEDQWGGRR A_0239_427 ---MEFRRLVTVALLLTLVMSIDSAPADQTETGRVSLR EGLENIFPCNADKCACLPKEESSTSYQCQSIDSSLTNCLD----------------DKCVTEDKWGGRR A_0031_367 ---MEFRRLVTVALLLTLVMSIDSAPADQTETGRVSLR EGLENIFPCNADKCACLPKEESSTSYQCQSIDSNLTNCLD----------------DKCVTEDKWGGRR A_0239_429 ---MEFRRLVTVALLLTLVMSIDSAPADQTETGRVSLR EGLENIFPCNADKCACLPKEESSTSYQCQSIDSSLTNCLE----------------------------- A_0031_368 ---MEFRRLVTVALLLTLVMSIDSAPADQTETGRVSLR EGLENIFPCNADKCACLPKEESSTSYQCQSIDSNLTNCLE----------------------------- A_0875_125 ---------------------------------RVSLR EGLENQFPCTPGRCACLPK-GSSYSYQCQSPQYSTADCVE----------------------------- A_0875_124 ---MEFRRLVTVALLLTLVMSIDSAPADQTETGRVSLR EGLENQFPCTPGRCACLPK-GSSYSYQCQSPQYSTADCVD----------------GRCITEGEWGGRR A_0885_021 ---MEFRRLVTVALLLTLVMSIDSAPADQTETGRVSLR EGLENQFPCTPGRCACLPK-GSSYSYQCQSPQYSTADCVD----------------GRCITEGEWGGRR A_0885_023 ---MEFRRLVTVALLLTLVMSIDSAPADQTETGRVSLR EGWVNQFPCHQDKCACLLK--GSHHYQCRSIQSSTADCVD----------------GRCITEGEWGRPR A_0039_057 ---MEFRRLVTVALLLTLVMSIDCAPVDQTETGRVSLR EGLENQFPCNPGRCACLPK--GSYSYQCQSPQSSTADCVD----------------GRCKTEDEWGVRR A_0055_120 ---------------------------------RDSLR EGFVNPFPCNPGRCACLSK--ESFSYQCQSTQYSTADCVD----------------GVCTKEGEWRGRR A_0520_060 ---MEFRRLVTVALLLTLVMSIDSAPADQTETGRVSLR EGLENQFPCNPGRCACLSK--GSFSYQCQSTQYSTADCVD----------------GICIKEGEWRGRR A_0520_061 ---MEFRRLVTVALLLTLVMSIDSAPADQTETGRVSLR EGLENQFPCNPGRCACLSK--GSFSYQCQSTQYSTADCVE----------------------------- A_0239_428 ---MEFRRLVTVALLLTLVMSIDSAPADQTETGRVSLR EGLENQFPCNPGRCACLSK--ESFSYQCQSTQYSTADCVD----------------GVCTKEGEWRGRR A_0039_054 ----------------------DSAPADQTETGRVSLR EGFVNPFPCDPGRCACVPKKGSSNSYGCQSIHSSRADCLD----------------------------- A_0855_128 ---------------------------------RVSLR EGFVNPFPCNPGSCACLPKKGSSNSYGCQSIHSSRADCLE----------------------------- A_0055_119 ---------------------------------RDSLR EGFVNPFPCNPGRCACLPKKGSSTSYQCQSIQSSTADCVE----------------------------- A_0885_022 ---------------------TDSAPADQTETGRVSLR EGFVNPFPCSPGRCACLPKKGSSNSYGCQSIHSSRADCVD----------------GLCVTEDNWQGRR A_0055_121 ----------------------YSAPADQTETGRVSLR EDLDNTFPCDTGRCACLPKKGSSTSYQCQSINSSTANCFD----------------DKCVTEDEWGGRR A_0885_020 ---MEFRRLVTVALLLTLVMSIDSAPADQTETGRVSLR EGFVNPFPCSPGRCACLPKKGSSNSYGCQSIHSSRADCVD----------------GLCVTEDNWQGRR A_0875_123 ---MEFRRLVTVALLLTLVMSIDSAPADQTETGRVSLR EGFVNPFPCSSGRCACLPKKGSSNSYGCQSIHFSRADCVD----------------GLCVTEDNWQGRR A_0055_118 ---------------------------------RDSLR EGFVNPFPCNPGRCACLPKKGSSTSYQCQSIQSSTADCVD----------------GECVTEDDWLGSR A_0048_225 ------------------------------ETMRVSLR EGFVNPFPCNPGRCACLPK-GS-YSYQCQSPQSSTADCVD----------------GECVTEDDWLGRR A_0855_127 ---MEFCRLVTVALLLTLVMSIDSAPADQTETGRVSLR EGFVNPFPCNPGSCACLPKKGSSNSYGCQSIHSSRADCLD----------------GLCVTENNW---- A_0031_366 ---MEFRRLVTVALLLTLVMSIDSAPADQTETGRVSLR EGFVNPFPCDPGRCACVPKKGSSNSYGCQSIHSSRADCLD----------------GLCVTENNW---- A_0025_026 ---MEFRRLVTVALLLTLVMSIDSAPADQTETGRVSLR EGFVNPFPCDPGRCACVPKKGSSNSYGCQSIHSSRADCLD----------------GLCVTENNW---- A_0025_025 ----------------------DSAPADQTETGRVSLR EGFVNPFPCDPGRCACVPKKGSSNSYGCQSIHSSRADCLE----------------------------- betulinusAMP44686 ---MEFRRLVTVALLLTLVMSIDSAPADQTETGRVSLR E--DDRFPCNSDQCACLPREGSSTSYQCQSTSASTADCVN----------------NNCITESEW---- ermineusAXL95601 ---MEFRRLVTVGLLLTLVMSTDSAPVDQTETGKVSLR Q--DEGFPCNSGQCACVPK--GQTSFECLTPPVNIALCRS----------------YECKWESEWGK-- magusDAC80614 MSKMEFRRLVTVALLLTLVLSIDSAPADQTETGRISLR E-TDETFPCDAGKCACSPKNG-DAEFICKDPSASTDECAD----------------GVCTTAANWG--- [Ggeo03-1] [New Framework] [ /--------Signal-------/------Pro-------/ /---C--------C-C-------C-----C-----C------C----C-C-------C-----C----C---] A_1387_341 ---MKIYLCLAVLLLLASAIVDSALHHKTEAIRKWRRKGR DENQC------PECRCSELTTARCEESKYCHPDASC-PTSSSCNN---------------------------- A_0048_130 ---MKIYLCFAVLLLLASTIVDSALHHKTETIRKWRRKGR DENQC------PECRCSELTTARCEESKHCHPDASC-PTSSSCNNGKCLCSHFLGGRCVRRSECNDSVC---- A_0855_008 ---MKIYLCFAVLLLLASTIVDSALHHKTEAIRKWRRKGR DENQC------PECRCTELTTARCEESKYCHPDASC-PTSSSCNNGKCLCSHFLGGRCVRRSECNDSVC---- A_0039_007 ---MKIYLCFAVLLLLASTIVDSALHHKTEAIRKWRRKGR DENQC------PECRCTELTTARCEESKYCHPDASC-PTSSSCNNGKCLCSHFLGGRCVRRSECNDSVC---- A_0239_453 ---MKIYLCFAVLLLLASTIVDSALHHKTEAIRKWRRKGR DENQC------PECRCTELTTARCEESKYCHPDASC-PTSSSCNNGKCLCSHFLGGRCVRRSECNDSVC---- A_0031_295 ---MKIYLCFAVLLLLASTIVDSALHHKTEAIRKWRRKGR DEDQC------PECRCSELTTARCEESKYCHPDASC-PTSSSCNNGKCLCSHFLGGRCVRRSECNDSVC---- V_CG13_060 ---MKIYLCLAVLLLLASTIVDSALHRKTEAIRNWRRKGR DENQC------PECRCSELTTARCEESKYCHPDASC-PTSSSCNNGKCLCSHFLGGRCVRRSECNDSVC---- V_1302_194 ---MKIYLCLAVLLLLASTIVDSALHHKTEAIRNWRRKGR DENQC------PECRCSELTTARCEESKYCHPDASC-PTSSSCNNGKCLCSHFLGGRCVRRSECNDSVC---- V_1258_024 ---MKIYLCLAVLLLLASTIVDSALHRKTEAIRNWRRKGR DENQC------PECRCSELTTARCEESKYCHPDASC-PTSSSCNNGKCLCSRFIGGRCVSHSECNDSVC---- A_0885_065 ---MKIYLCFAVLLLLASTIVDSALHHETEAIRKWRRKGR DQDQC------PECRCTELTTARCEESKYCHPDASC-PTSSSCNN---------------------------- V_1278_015 ---MKIYLCLAVLLLLASTIVDSALHRKTEAIRNWRRKGR DESQC------PECRCSELKTAICHESAYCYY-ASC-PTSPSCNNGKCLCSRFIGGRCVSHSECNDSVC---- K_0010_012 MGSMKIYLCLAILLLPASTIVDSALRDKTETIRNWRRKGR DEELC------PECRCAELKTARCTESEYCNSEASC-PTSPTCNNGNCLCTRFHGGTCVSHSECNDEIC---- K_0010_013 MGSMKIYLCLAILLLPASTIVDSALRDKTETIRNWRRKGR DEEQC------SDCKCIDLKNATCTESKYCKSGALC-PTDSTCNSGNCLCRNFHGG----------------- betulinusALM87512 ---MKIYLCLAVLLLLASTTVDSALRDKAETIRNWRRKGR DENLC------PECRCSELKTAECDESKYCHSDHSC-PTSPTCNNGKCLCTHFLGGRCSRTSECNGSVC---- A_0885_156 ---MKIYLCLAILLLLASTIVDSGLLDITQTIRNWRRKGR DDSQC------NECNC--------------------------------------------------------- A_0025_012 ---MKIYLCLAILLLLASTIVDSGLLDITQTIRNWRRKGR DDSQC------NECNCAHLKKAQCTDRIYCDFEAPC-PSDYWCRNGKCLCARFHMGRCSKSSECMPYQC---- A_0239_002 ---MKIYLCLAVVLLLASTIVDSGLLDKTQALRNWRRKGR DESLC------NDCRCSNLINARCTKSEYCSMDASC-PTNPDCSGSKCLCKQFHGGLCVSKSECSDSVC---- magusQFQ61142 MGSMNIYLCLAFLLLLASTIVDSGVLDKIETARTWR---R DEGQC------DQCSCATLKKPECVSRMSC---ITCHSTNWRCNGDDCFCTQIHGGFCVTPSECKVEEC---- geographusBAO65658 MGSMKIYLCLAFLLLLPFTIVDSGLLDKIETIRNWR---R DESKC------DGCNCAELRSSRCTEAMFCLTPELC-TPSVSCPTGECRCTKFHQSRCTRFEECVPNKCRDA- [Ggeo03-2] [New Framework] [ /--------Signal--------/-----Pro-------/ /---C--------C-C-------C-----C-----C------C----C-C-------C----CC----C---] V_1302_195 MGRMKIYLCLAIVLLLASAIADSVL-DKTKTERDWR--SR DENQCPQCDDCPSCRCNHLKEGICVPHYDCGT-DDC-PAAPCSTVGECKCDFFHLGMCVSPSDCNDAVCANRQ magusQFQ61143 ---MKIYLYLAIVLLVASAIVGLAL-HKTKTARNWRHTER DESQCER----NECRCNNVTKGICVPKDECS--ASC-ETNSTCRNGTCLCKYFHLGFCVPKSCCSHEAC---- [Pmag Superfamily 01] Framework VI/VII [ /-------Signal------/-------Pro----------------/--C-----C---CC-----C-C----C-] A_0055_379 ----------------GVSGEDGQMMRGKNPSDTYIRAVRGSAGEHRSNTCPGLPSCNDACCQEDRRCWCLKIQCE- magusQFQ61150 MKAALFLLLVLALGTIGVSGEDGQTMQGKNPSDTYIR---------------------------------------- betulinusALM87505 MKVALFILLVLALGTLGVNGEDGQMMQGKNPSDTYIRALRRSAGKHRSSVCSGLPSCNDACCHAGRRCWCLQIQCES [Pmag Superfamily 02] [Framework XXII] [ /-----Signal----/---C---------C---------C------------C--C------C-----------C--------C------] A_0039_021 MKTVAVFLVVALAVAYGQFFCPENESD-VNCIETMPTAVTCMQS-KDGSYSYACGYCGKKKDTCFGDKKAVKDYYCQRQKIVNNCG--GPAL A_0048_043 MKTVAVFLVVALAVAYGQFFCPENESD-VNCIETMPTAVTCMQS-KDGSYSYACGYCGKKKDTCFGDKKAVKDYYCQRQKIVNNCG--GPAL A_0055_020 MKTVAVFLVVALAVAYGQFFCPENESE-LNCIETMSTAATCMQS-KDGSYSYACGYCGKKKDTCFGDKKPVRDYYCQRQKIVNNCG--GPAL A_0885_027 MKTVAVFLVVALAVAYGQFFCPENESE-LNCIETMSTAATCMQS-KDGSYSYACGYCGKKKDTCFGDKKPVRDYYCQRQKIVNNCG--GPAL A_0855_007 MKTVAVFLVVALAVAYGQFFCPENESE-LNCIETMSTAATCMQS-KDGSYSYACGYCGKKKDTCFGDKKPVRDYYCQRQKIVNNCG--GPAL A_0520_041 MKTVAVFLVVALAVAYGQFFCPENESE-LNCIETMSTAATCMQS-KDGSYSYACGYCGKKKDTCFGDKKPVRDYYCQRQKIVNNCG--GPAL A_0239_196 MKTVAVFLVVALAVAYGQFFCPENESE-LNCIETMSTAATCMQS-KDGSYSYACGYCGKKKDTCFGDKKPVRDYYCQRQKIVNNCG--GPAL A_0031_089 MKTVAVFLVVALAVAYGQFFCPENESE-LNCIETMSTAATCMQS-KDGSYSYACGYCGKKKDTCFGDKKPVRDYYCQRQKIVNNCG--GPAL A_0025_046 MKTVAVFLVVALAVAYGQFFCPENESE-LNCIETMSTAATCMQS-KDGSYSYACGYCGKKKDTCFGDKKPVRDYYCQRQKIVNNCG--GPAL A_1387_057 MKTVAVFLVVALAVAYGQFFCPENESE-LNCIETMTTAATCMQS-KDGSYSYACGYCGKKKDTCFGDKKPVRDYYCQRQKIVNNCG--GPAL A_0875_118 MKTVAVFLVVALAVAYGQFFCPENESE-LNCIETMSTAATCMQS-KDGSYSYACGYCGKKKDTCFGDKKPVRDYYC---------------- V_CG13_014 MKTVAVFLVVALAVAYGQFFCPENENE-LNCIETMATAATCMQS-KDGSYSYACGYCGKKKDTCFGDKTPVTDYYCQIQKIVNHCS--GPAL V_1302_019 MKTVAVFLVVALAMAYGQFFCPENENE-LNCIETMATAATCMQS-KDGSYSYACGYCGKKKDTCFGDKTPVTDYYCQIQKIVNHCS--GPAL V_1258_013 MKTVAVFLVVALAVAYGQFFCPENENE-LNCIETMATAATCMQS-KDGSYSYACGYCGKKKDTCFGDKTPVTDYYCQIQKIVNHCS--GPAL V_1278_038 MKTVAVFLVVALAVAYGQFFCPENENE-LNCIETMATAATCMQS-KDGSYSYACGYCGKKKDTCFGDKTPVTDY------------------ A_0048_044 MKTVAVFLVVALAVAYGQFFCPESEDDPLNCVETMATSATCMKS-SDGSFSYACGYC----------------------------------- V_1258_015 MKTVAVFLVVALAVAYGQFFCPESEDDPLNCVETMATAATCMKS-SDGSFSYACGYCGKKKETCFGNKQPVSDYYCQTQNIVNHCS--GTVL A_0520_040 MKTVAVFLVVALAVAYGQFFCPESEDDPLNCVETMATSATCMKS-SDGSFSYACGYCGKKKETCFGNKQPVSDYYCQTQKIVNHCS--GTVL K_0010_045 MKTVAVFLVVALAVAYGQFFCPESEDDPLNCVETMATSATCMKS-SDGSFSYACGYCGKKKETCFGNKQPVSDYYCQTQKIVNHCS--GTVL V_1258_014 MKVVAVFMIVALAVAYGQFFCPESASDSLNCLETMASSATCMQSNDDGSYSYVCGYCGKKKETCFGNKQPVSDYYCQTQNIVNHCS--GTVL A_0239_198 MKAVAVFLVVALAVAYGQFFCPDSADDPLNCIETMATSATCMKSNKDGSHSYVCGYCGKKKESCFGDKVPVTDYGCQIEQIANHCG--GPVV A_0855_006 MKAVAVFMIVALAVAYGQFFCPESASDPLNCLETMASSATCMQSEADGSYSYVCGYCGKKRETCFGNKVAVRDYYCQTNGIANTCG--GAAQ A_0885_026 MKAVAVFMIVALAVAYGQFFCPESASDPLNCLETMASSATCMQSEADGSYSYVCGYCGKKKETCFGNKVAVRDYYCQTNGIANTCG--GAAQ A_0875_037 MKAVAVFMIVALAVAYGQFFCPESASDPLNCLETMASSATCMQSEADGSYSYVCGYCGKKKETCFGNKVAVRDYYCQTNGIANTCG--GAAQ A_0055_019 MKAVAVFMIVALAVAYGQFFCPESASDPLNCLETMASSATCMQSEADGSYSYVCGYCGKKKETCFGNKVAVRDYYCQTNGIANTCG--GAAQ A_0039_020 MKAVAVFMIVALAVAYGQFFCPESASDPLNCLETMASSATCMQSEADGSYSYVCGYCGKKKETCFGNKVAVRDYYCQTNGIANTCG--GAAQ V_CG13_013 MKVVAVFMIVALAVAYGQFFCPESASDSLNCLETMASSATCMQSNDDGSYSYVCGYCGKKKETCFGNKVGVQDYYCQTNGIANTCG--GAAQ V_1302_020 MKAVAVFMIVALAVAYGQFFCPESASDSLNCLETMASSATCMQSNDDGSYSYVCGYCGKKKETCFGNKVGVQDYYCQTNGIANTCG--GAAQ A_1387_059 MKAVAVFMIVALAVAYGQFFCPESASDPLNCLETMASSATCMQSEADGSYSYVCGYCGKKKETCFGNKVAVRDYYCQTNGIANTCG--GAAQ A_0520_042 MKAVAVFMIVALAVAYGQFFCPESASDPLNCLETMASSATCMQSEADGSYSYVCGYCGKKKETCFGNKVAVRDYYCQTNGIANTCG--GAAQ A_0048_042 MKAVAVFMIVALAVAYGQFFCPESASDPLNCLETMASSATCMQSEADGSYSYVCGYCGKKKETCFGNKVAVRDYYCQTNGIANTCG--GAAQ A_0025_047 MKAVAVFMIVALAVAYGQFFCPESASDPLNCLETMASSATCMQSEADGSYSYVCGYCGKKKETCFGNKVAVRDYYCQTNGIANTCG--GAAQ A_0239_197 MKAVAVFMIVALAVAYGQFFCPESANDPLNCLETMASSATCMQSEADGSYSYVCGYCGKKKETCFGNKVAVRDYYCQTNGIANTCG--GAAQ A_0031_090 MKAVAVFMIVALAVAYGQFFCPESASDPLNCLETMASSATCMQSEADGSYSYVCGYCGKKKETCFGNKVAVRDYYCQTNGIANNCG--GAAQ V_1278_036 MKAVAVFMIVALAVAYGQFFCPESASDSLNCLETMASSATCMQSNDDGSYSYVCGYCGKKKETC---------------------------- A_0875_036 MKAVAVFMIVALAVAYGQFFCPESASDPLNCLETMASSATCMQSEADGSYSYVCGYCGKKKDTCFGDK------------------------ A_1387_060 MKAVAVFMIVALAVAYGQFFCPESASDPLNCLETMASSATCMQSEADGSYSYVCGYCGKKKDTCFGDK------------------------ V_1278_037 MKTVAVFLVVALAVAYGQFFCPASKDEPLNCIETMASAATCMKSTTDGTFSYVCGYC----------------------------------- A_0885_302 ------------AVAYGQFFCPESASDPLNCLETMASSATCMQSEADGSYSYVCGYCGKKKESCSGEKVPVSDYSCQIHNVVNNCG--GAAL A_1387_058 MKTVAVFLVVALAVAYGQFFCPASKDEPLNCIETMASAATCMKSTTDGTFSYVCGYCAKTKVSCSGEKVPVSDYSCQIHNVVNNCG--GAAL A_0025_048 MKTVAVFLVVALAVAYGQFFCPASKDEPLNCIETMASAATCMKSTTDGTFSYVCGYCGKKKESCSGEKVPVSDYSCQIHNVVNNCG--GAAL K_0010_046 MKVVAVFMMVALAVAYGQFFCPESANDPLNCMETMASSATCMQSNADGSYSYVCGYCGKKKETCFGNKVAVQDYYCQTNSIANTCG--GAAQ betulinusALM87501 MKAVAVFLVVALAVAYGQFFCPESENDPLNCIETMASAATCMKSKADGSYSYACGYCGKKKESCFGDKVPVTDYNCKTRKIVNPCG--GPAL geographusBAO65649 MKTVAVFLVVALAVAYEQFFCPSSKEDSLNCIETMATTATCMKSNKGEIYSYACGYCGKKKESCFGDKKPVTDYQCQTRNIPNPCG--GAA- andremeneziATF27513 MKAVAVFLVVALAVAYGQFFCPKSKDEPLNCFESMPNSATCMQSTDGSL-SYACGYCGKKRETCSGNKVPVRNYDCQRNKVPNPCGPGGAAL magusQFQ61151 MKTVAVFLVVALAVAYGQFFCPNSENDPLNCVETMATTATCMQSNKDKSYSYACGYCGKKKESCFGNKVPVRDYNCKSRNIVNPCG--GPAL [Rimp Superfamily 01] [Framework XXII] [ /-----Signal-----/--------------C--------------------------------C-C-------------------------C------C------------------C-C----------------C] A_0055_353 MARFLSILLCIAVVMALAAGIYYPLGDKPVGPCNTNDISKTERYSNHSGRWESYHDGRWKSHNTYCTCASGEEHFTAIDATSTYYTILYRIYVCGAPTSPCSRA-IPVTDSNHGTRRMQCTCGQYKYFLSYPLGWHVRCK A_0855_062 MARFLSILLCIAVAVALAAGIGYPDISKPIGPCETNDISKTEVYSNRFGRWE--------SHNTYCTCASGEEHFAASDTTSSYATVSYRIYVCGAPTSPCSRA-IPVTDSNDGTRRMQCTCGQYKYFVSNRLGWHVRCK A_0855_063 MARFLSILLCIAVAVALAAGIGYPDISKPIGPCETNDISKTEVYSNRFGRWE--------SHNTYCTCASGEEHFAAEDTTSS-STGPYKIYVCGAPTYSCLGAMIPVTDSDDGTRRMQCTCGQYKYFVSNRLGWHVRCK A_0875_077 MARFLSILLCIAVAVALAAGIGYPDISKPIGPCETNDISKTEVYSNRFGRWE--------SHNTYCTCASGEEHFAASDTTSSYATVSYRIYVCGAPTSPCSRA-IPVTDSNDGTRRMQCTCGQYKYFVSNRLGWHVRCK V_1302_066 MARFLSILLCIAVAVALAAGIYYPSVDKPIGPCNTNDISKTEMYSNRYGRWE--------SHNTYCTCASGEERFAASDTTSSHATMSYRIYVCGAPTSPCSGATIPVTDSDDGTRRMQCTCGQYKYFVSNSLGWHVRCK A_0031_049 MARFLSILLCIAVAVALAAGIGYPDISKPIGPCETNDISKTEVYSNRFGRWK--------SHNTYCTCASGEEHFAASDTTSSYATVSYRIYVCGAPTYSCPGAMKPVTDSDDGTRRMQCTCGQYKYFVSNRLGWHVRCK A_0055_105 MARFLSILLCIAVAVALAAGMLYPD-NRPSGLCETNDISKTEVYSDRFGKWE--------SGYTYCTCASGEEHFAAEGTNSS-STGPYKIYVCGAPTYSCPEAMIPVTDSDDG---MQCTCGQYVYFVSRLLGWHVRCK A_0855_065 MARFLSILLCIAVAVALAAGIGYPDISRPIGRCETNDISKTEVYSNRFGKWV--------SGYTYCTCASGEEHFAAEDTTSS-STGPYKIYVCGAPTSPCSRA-IPVTDSNDGTRRMQCTCGQYKYFVSNRLGWHVRCK A_0855_064 MARFLSILLCIAVAVALAAGRRYPD--RPIGRCETNDISKTEVYSNRFGKWV--------SGYTYCTCASGEEHFAAEDTTSS-STGPYKIYVCGAPTYSCLGAMIPVTDSDDGTRRMQCTCGQYKYFVSNRLGWHVRCK A_0885_071 MARFLSILLCIAVAVALAAGRRYPD--RPIGRCETNDISKTEVYSNRFGKWV--------SGYTYCTCASGEEHFAAEDTTSS-STGLYKIYVCGAPASPCSGATIPVTDSDDGTRRMECTCGQYKYYVSNRLGWHVRCK A_0875_076 MARFLSILLCIAVAVALAAGRRYPD--RPIGRCETNDISKTEVYSNRFGKWV--------SGYTYCTCASGEEHFAAEDTTSS-STGPYKIYVCGAPASPCSGATIPVTDSDDGTRRMECTCGQYKYFVSNRLGWHVRCK A_0239_071 MARFLSILLCIAVAVALAAGIYYPD-NRPIGLCETYDISKTEVYSDRFDKWV--------SGSTYCTCASGEEHFAAEDTTSS-SKGPYKIYVCGAPTYSCPGAMIPVTDSGDGTRRMQCTCGQYKYFVSNRLGWHVRCK V_1302_067 MARFLSILLCIAVAVALAAGIYYPSVDKPIGPCNTNDISKTEMYSNRFGRWE--------SPYIYCTCAGGEEHFAANDTITSYATVSYRIYVCGAPTSPCSGAMIPVTDSNDGTRRMQCTCGQYKYFVSNSLGWHVRCK V_CG13_073 MARFLSILLCIAVAVALAAGIYYPPVEKPIGPCETNDISKTEMYSNRFGRWE--------SPYIYCTCAGGEEHFAANDTITSYATVSYRIYVCGAPTSPCSGAMIPVTDSNDGTRRMQCTCGQYKYFVSNPLGWHVRCK A_1387_139 MARFLSILLCIAVAVALAAGIGYPDISKPIGPCNTNDISKTEVYSNRFGRWE--------SYNTYCTCASGEEHFAANDTTSSYATVSYRIYVCGAPTYSCPGAMIPVTDSDDGTRRMECTCGQYKYFVSNRLGWHVRCK V_1278_012 MARFLSILLCIAVAVALAAGIYYPP--KPIGPCNTNDISKTEMYSNRNDRWE--------SHYTYCTCASGMERFAANDTTSSQSTMSYRIYVCGALTSPCSGATIPVTDSDDGTRRMQCTCGQYKYFVSNHLGWHVRCK A_0025_144 MARFLSILLCIAVAVALAAGIGYPDISKPVGPCETNDISKTEVYSNRFSRWE--------SHYTYCTCASGEEHFAASDTTSSYAT--YRIYVCGAPTYSCPGAMIPVTDSDDGTRRMQCTCGQYKYFVSNRLGWHVRCK A_0885_072 MARFLSILLCIAVAVALAAGIGYPDISKPIGPCETNDISKTEVYSNRFGRWE--------SHYTYCTCASGEEHFAASDTTSSYAT--YRIYVCGAPTSPCSRA-IPVTDSNDGTRRMQCTCGQYKYYVSNRLGWHVRCK A_0039_170 MARFLSILLCIAVAVALAAGIGYPDISKPVGPCETNDISKTEVYSNRFSRWE--------SHYTYCTCASGEEHFAASDTTSSYAT--YRIYVCGAPTSPCSRA-IPVTDSNDGTRRMQCTCGQYKYFVSNRLGWHVRCK A_0055_104 MARFLSILLCIAVAVALAAGIGYPDVSKPIGPCETNDISKTEVYSNRFGRWK--------SHYTYCTCASGEEHFAANDTTSSNAAVSYRIYVCGAPASPCSGATIPVTDSDDGTRRMQCTCGQYKYFVSNRLGWHVRCK A_0048_052 MARFLSILLCIAVAVALAAGIGYPDVSKPIGPCETNDISKTEVYSNRFGRWK--------SHYTYCTCASGEEHFAADDTTSSNAVVSYRIYVCGAPTSPCSRA-IPVTDSNDGTRRMQCTCGQYNYFVTYRLGWHVRCK A_0239_070 MARFLSILLCIAVAVALAAGIGYPDVSKPIGPCETNDISKTEVYSNRFGRWK--------SHYTYCTCASGEEHFAANDTTSSNAAVSYRIYVCGAPASPCSGATIPVTDSDDGTR------------------------ A_0520_062 MARFLSILLCIAVAVALAAGIGYPDVSKPIGPCETNDISKTEVYSNRFGRWK--------SHYTYCTCASGEEHFAADDTTSSNAVVSYRIYVCGAPASPCSGATIPVTDSDDGTRRMQCTCGQYKYFVSSRLGWHVRCK A_0048_053 MARFLSILLCIAVAVALAAGIGYPDVSKPIGPCETNDISKTEVYSNRFGRWK--------SHYTYCTCASGEEHFAADDTTSSNAVVSYRIYVCGAPASPCSGATIPVTDSDDGTRRMQCTCGQYKYFVSSRLGWHVRCK V_1258_043 MARFLSILLCIAVAVALAAGIYYPSVDKPIGPCNTNDISKTEWYSNRYGRWE--------SH-TYCTCASGEEHFAASDTTSSHATVSYRIYVCGAPTSPCSGATIPVTDSDDGTRRMQCTCGQYKYFVSNSLGWHVRCK A_0031_048 MARFLSILLCIAVVMALAAGIYNQN-DKPIGSCKTNDISNTEVYSNRLGKWE--------SGYTYCTCASGEEHFAASDTTSSYATVSYRIYVCGAPASPCPEATIPVTDSDNGTRKMQCTCGQYKYFVSNRLGWHVRCK K_0010_081 MARFLSILLCIAMAVALAAGIYYPN-GRPIGPCSTNDISKTEVFSIRNARWE--------LHYSYCTCASGEDYIEAEDRTTSSTTVSYKIYECGMPTYSCSGGTFPVTDADDGPRRMQCTCGQYKYFVSPTLGWHVRCK magusQFQ61144 MARFLSILLCFAMATGLAAGIRYPD--RVLGRCSTHDLSKMEIDTNLDGVYS--------PHRSFCTCGSGEVYFTAKDRRNH---SNYRVYVCGMPTEFCT-AENPVRDPKKGNRWLQCRCRQYKMVIYR--DWLVLCE imperialisAME17683 MARFLSILLCFAMATGLAAGIRYPD--RVLGRCSTHDLSKMEIDTNLDGVYS--------PHRSFCTCGSGEVYFTAKDRRNH---SNYRVYVCGMPTEFCT-AENPVRDPKKGNRWLQCRCRQYKMVIYR--DWLVLCE [Rimp Superfamily 02] [formerly Cerm Superfamily 07 in Abalde et al. 2018 GBE 10:2643–2662] [Framework IX] [ /--------Signal--------/----------------Pro---------------/ /-C----C-----C---C-C-----C-------/-P] V_CG13_109 -RLSTMHSVILMLVLMFAFDNVDGDGPGQTARDVDNGKFMSSLQSEGKLASFFTLRTQD NMCDLQFCP--NQCSSPCWCTTTNTCEG---DRK--- V_1302_052 MRLSTMHSVILMLLLMFAFDNVDGDGPGQTARDVDNGKFMSSLQSEGKLASFFTLRTQD NMCDLQFCP--NQCISPCWCTTTNTCEG---DRK--- A_0855_254 -----------------------GDGPGQTARDVDNGKFMSSLQSEGKLASFFTLRTQD NMCDLQSCP--DHCGSPCWCTTDNTCEG---NRK--- A_1387_022 -----MHSVILMLLLMFAFDNVDGDGPGQTARDVDNGKFMSSLQSEGKLASFFTLRTQD NMCDLQSCP--DHCGSPCWCTTDNTCEG---DRK--- A_0025_093 -----MHSVILMLLLMFAFDNVDGDGPGQTARDVDNGKFMSSLQSEGKLASFFTLRTKD NMCDLQSCP--DHCGSPCWCTTDNTCDG---DRK--- A_0055_346 MHLSTMHSVIPMLVLLFAFDNVVGDGPGQTARDVDNGKFMSSLQSEGEAARFIMLGEKQ QLCQFRSCP--YHCGPHCQCKPDNSCGN---Y-GKRDW V_1302_314 -----MHSVILMLLLMFAFDNVDGDGPGQTARDVDNGKFMSSLQSEGEPARFFMLGEKR QLCEARSC------------------------------ V_1302_317 ------------------------------ARDVDNGKFMSSLQSEGKPARFFMLGEKR QLCESRSCP--DQCGPDCRCNANNHCDD---YYGK--- V_1302_316 ------------------------------ARDVDNGKFMSSLQSEGKPARFFMLGEKR QLCEARSCP--NQCGLGCRCDANNRCTD---YHGK--- V_CG13_108 MRLSTMHSVILMLVLMFAFDNVDGDGPGQTARDVDNRKFMSRLRSGGEPARFFMLGEKR QLCESRSCP--DQCGPDCRCNANNHCDD---YHGK-- V_1278_022 MRLSTMHSVILMLLLMFAFDNVDGDGPGQTARDVDNRKFMSRLRSGGKPARFFMLGEKR QLCESRSCP--DQCGPDCRCNANNHCDD---YYGK-- A_0055_051 MRLSTMHSVILMLLLMFAFDNVDGDGPGQTARDVDNGKFMSSLQSEGKPARFFLLGEKR QLCEFRSCP--DQCGPDCRCDVNNHCDD---YYGK-- A_0031_070 MRLSPMHSVILMLLLMFAFDNVDGDGPGQTARDVDNGKFMSSLQSEGKPARFFLLGEKR QLCEFRSCP--DQCGPDCRCDVNNHCDD---YYGK-- A_0039_044 MRLSTMHSVILMLLLMFAFDNVDGDGPGQTARDVDNGKFMSSLQSEGKPARFFLLGEKR QLCEFRSCP--DQCGPDCRCDVNNHCDD---YYGK-- A_0239_382 MRLSPMHSVILMLLLMFAFDNVDGDGPGQTARDVDNGKFMSSLQSEGKPARFFLLGEKR QLCESRSCP--DQCGPDCRCDANNHCDD---YHGK-- A_0025_094 MRLSTMHSVILMLLLMFAFDNVDGDGPGQTARDVDNGKFMSSLQSEGKPARFFLLGEKQ QLCESRSCP--YQCGSSCRCDANNQCND---YHGK-- K_0010_326 -----MHSVILMLLLMFAFDNVDGDGPGQTAKDVDNGKFMSSLQSEGEPARFFMLGEKR QLCEFRSCP--DHCGPDCRCDANNDCED---FHGK-- betulinusAMP44700 MRLPTMHSVILMLLLMFAFDNVDGD--GQTARDVDNGKFMSSLQSEGMPARFFMLGEKR QLCESRSCP--NDCGPDCRCDANNHCED---YWK--- ermineusAXL95416 MCLSTMPSVILMMVLMFAFDNVDGDGPGQTARDGDNGKFMSSLQSEGEPARFFMPGEKR ALCESRSCP--DDCGPDCRCNTDDYCVD---YWN--- imperialisAME17684 MRLTTMHSVILMLLLVFAFDNVDGDEPGQTARDVDNRNFMSILRSEGKPVHFLRAIKKR D-CTGQACTTGDNCPSECVCNEHHFCTGKCCYFLHA- [Rimp Superfamily 03] [Framework XX] [ /------Signal------/------------Pro---------/ /-----C----------------CC----C----CC----C-C----C-C------] A_1387_096 MSKSGMLLFVLLLLLPLAFPKLVP------AGRSVARRYGNLGAK RDVSLSCVSPTTSNLQGPWQSRKCCETKQCSPTHCCTSSSCTCVGTSCYCRAPITVL A_1387_094 MSKSGMLLFVLLLLLPLAFPKLVPGNMFHLSGRSVARRYGNLGAK RDVSLSCVSPTTSNLQGPWQSRKCCETKQCSPTHCCTSSSCTCVGTSCYCRAPITVL V_1302_203 MSKSGILLFVLLLLLPLAFPKLVPGNMFHLSGRSVARRYGNLGAK RDVPLSCVSTTTSNLQGPWQSRKCCETKQCSPTHCCTSSSCTCQGTSCYCPSPITAL V_CG13_017 MSKSGILLFVLLLLLPLAFPKLVP------ARRSVARRYGNLGAK RDVPLSCVSTTTSNLQGPWQSRKCCETKQCSPTHCCTSSSCTCQGTSCYCPSPITAL V_1302_205 MSKSGILLFVLLLLLPLAFPKLVP------AGRSVARRYGNLGAK RDVPLSCVSTTTSNLQGPWQSRKCCETKQCSPTHCCTSSSCTCQGTSCYCPSPITAL V_1258_003 MSKSGILLFVLLLLLPLAFPKLVP------AGRSVARRYGNLGAK RDVPLSCVSTTTSNLQGPWQSRKCCETKQCSPTHCCTSSSCTCQGTSCYCPSPITAL A_0855_094 MSKSGMLLFVLLLLLPLAFPKLVP------AGRSVARRYGNLGAK RDVPLSCVSTTTSNLQGPWQSRKCCETKQCSATHCCTSSSCTCQGTSCYCPSPITAL V_1302_204 --------------------------------------------- ----LIFVSTTTSNLQGPWQSRKCCETKQCSPTHCCTSSSCTCQGTSCYCPSPITAL A_0055_182 MSKSGMLLFVLLLLLPLAFPKLVP------AGRSVARRYGNLGAK RDVSLSCVSTTTSNLQGPWQSRKCCETKQCSPTHCCTSSSCTCEGTSCYCPSPITAL A_0885_154 --------------------------------------------- ------------------WQSRKCCETKQCSPTHCCISSSCTCEGTLCYCPSRITAL A_0039_040 MSKSGMLLFVLLLLLPLAFPKLVP------VGRSVARRYGNLGAK RDVSLCCVSTTTSNLQGPWQSRKCCETKQCSPTHCCISSSCTCEGTLCYCPSRITAL A_0048_336 --------------------------------------------- -----------TSNLQGPWQSRKCCETKQCSPTHCCISSSCTCEGTSCYCPSPITAL A_0520_037 MSKSGMLLFVLLLLLPLAFPKLVP------AGRSVARRYGNLGAK RDVSLSCVSTTTSNLQGPWQSRKCCETKQCSPTHCCISSSCTCEGTSCYCPSPITAL A_0239_452 MSKSGMLLLVLLLLLPLAFPKLVS------AGRSVARRYGNRGAK RDVSLSCVSTTTSNLQGPWQRRKCCETKQCSPTNCCTSSSCTCEGTSCYCSSPTTAL K_0010_071 MSKSGMLLSVLLLLLPLAFSKLVP------AGRSVARRYGNLGAK HHVPLSCVSPSTPSLKGSWQSKKCCYTKQCSPIHCCTSSFCSCQGTACYCPDSRTTR betulinusAMP44705 MSKSGMLLFV-LLLLPLAITKLVP------AGRSVARRYGYLGAK REVPLSCVDPLTPGLTGSWEDKKCCYTKQCSPTNCCTSSSCTCDGPACLC------- magusQFQ61145 MSKSGMLLFVLLLLLPLAIPELAP------AGRSVTHHFRDFGAK RSVPISCVNPSTPNLQGSWQDKKCCSTKL---------------------------- imperialisAME17685 MSKSGMLLFVLLLLLPLAIPELAP------AGRSVTHHFRDFGAK RSVPISCVNPSTPNLQGSWQDKKCCSTKLCSPTNCCESSTCSCVEGSCQCL------ [Rimp Superfamily 04] [Framework XXIII] [ /-------Signal--------/C---C--------C--CC-C--------------------------------] A_0855_015 MKFFTCLLFSLVVLTMVFNNVDGCDNRCTGVGGFPSCRRCCTCMDGTDVVRADGHHSPMKEPAGERNLLKLWSFH A_0885_038 MKFFTCLLFSLVVLTMVFNNVDGCDDECIGVSGYPSCSNCCTCKGGTDKARADGHHSPMKEPAGERNLLKLWSFH A_0875_034 MKFFTCLLFSLVVLTMVFNNVDGCDNRCTGVGGYPSCRRCCTCMDGTDVVRADGHHSPMKEPAGERNLLKLWSFH A_0875_035 MKFFTCLLFSLVVLTMVFNNVDGCDDECIGVSGYPSCSICCTCKGGTDKARADGHHSPMKEPAGERNLLKLWSFH V_CG13_039 MKIFACIIFSLVVLTMVFNNVDGCDNTCTGVGGYPSCYHCCTCKDGTDESRADGHHSPMKEPAGERNLLKLLSFH V_CG13_041 MKFFACLLFSLVVLTMVFNNVDGCDNTCTGVGGYPSCYHCCTCKDGTDESRADGHHSPMKEPAGERNLLKLLSFH V_1302_032 MKFFACLLFSLVVLAMVFNNVDGCDSSCTGVGGYSSCSRCCTCKDGTDYARADGHHSPMKEPAGERNLLKLLKFH V_1278_009 MKFFACLLFSLVVLTMVFNNVDGCDNTCTGVGGYPSCYHCCTCKDGTDEARADGHHSPMKEPAGERNLLKLLSFH V_1258_046 ------------VLTMVFNNVDGCDNTCTGVGGYPSCYRCCTCKDGTDEARADGHHSPMKEPAGERNLLKLLSFH V_1258_047 MKFFACLLFSLVVLAMVFNNVDGCDSSCTGVGGYSSCSRCCTCKDGTDYARADGHHSPMKEPAGERNLLKLLKFH A_0039_006 MKFFTCLLFSLVVLTMVFNNVDGCDNSCTGVGGYPSCRRCCTCQDGIDVVRADGHHSPMKEPAGERNLLKLLSFH A_0025_003 MKFFTCLLFSLVVLTMVFNNVDGCDNGCTGVGGYPSCRRCCTCQDGVDVVRADGHHSPMKEPAGERNLLKLLSFH A_0520_144 MKFFTCLLFSLVVLTMVFNNVDGCDNRCIGVGGYSSCTRCCTCQNGVDKVRADGHHSPMKEPAGERNLLKLLSFH A_0048_040 MKFFTCLLFSLVVLTMVFNNVDGCDNGCIGVGGYSSCTRCCTCQNGVDKVRADGHHSPMKEPAGERNLLKLLSFH A_0055_006 MKFFTCLLFSLVVLTVVFNNVDGCDSTCTGVSGYPSCSRCCICQDGIDVVRADGHHSPMKEPAGERNLLKLRSFH A_0031_056 MKFFTCLLFSLVVLTVVFNNVDGCDSTCTGVSGYPSCSRCCICQDGIDVVRADGHHSPMKEPAGERNLLKLRSFH A_0239_079 MKFFTCLLFSLVVLTVVFNNVDGCDSTCTGVSGYPSCSRCCNCQDGIDVVRADGHHSPMKEPAGERNLLKLRSFH imperialisAME17686 MKFFTCLLLLLVVLTVVFDNVDACDRSCTGVMGHPSCATCCACFTSAGKRHADGQHSRMKVRTGAKNLLKRMPLH [Rimp Superfamily 05] [Framework VI/VII] [ /-------Signal-----/-------------Pro------------/ /C--C----CC----C---------C-] A_0055_079 ------------------DGSPGNTMYSRKGAGAASGIKRFQKTFL-RG NCGNCPKEPCCHGDKCMTEPGYPPFCGN A_0520_035 ------------------DGSPGNTMYSRKGAGAASGIKRFQKTFL-RG NCGNCPKEPCCHGDKCMTEPGYPPFCGN V_CG13_201 MMKIGLIICLLLIAFMTGDGSPGNTMYSWKGAGFASGKKRFQKTFL-RR SCTFCPREPCCDGDHCVNSD--PPFCGN V_1302_111 MMKIGLIICLLLIAFMTGDGSPGNTMYSWKGAGFASGKKRFQKTFL-RR SCTFCPREPCCDGDHCVNSD--PPFCGN A_0055_073 ---------------------------------------RFQKTFL-RR SCTYCPREPCCNGDHCVSDNGY-RFCGN K_0010_331 MMKIGLIICLLLIAFMTGDSSPGNTMYRRKGTGIAPGIKRFQKSFL-RR-SCTNCPEEPCCYGDQCMPNPGHEPFCGG betulinusALM87489 MMKIGLIICLLLIAFMK-DGSPGNTLYSRKGTDFASGIKRFQKSFL-RR SCHNCPEEPCCYGDQCMLDPGHEPFCGN magusQFQ61146 -MKTGLIIICLLSIDFMDAGGSPGDTLYSRKRTGTDSGMKRFQKTFFRR QCVDCPEEPCCYGDKCMADPGSEPFCGN imperialisAME17687 -MKTGMIICLLLIAFMDADGSPGDTLYSQKTADTDSGMKRFQKTFQKRR -CVFCPKEPCCDGDQCMTAPGTGPFCG- [Rmil Superfamily 01] [formerly Cerm Superfamily 09 in Abalde et al. 2018 GBE 10:2643–2662] [Framework XIII] [ /------Signal------/-------Pro--------/ /---C---C------C---CC-----C-------C-C------------] A_0055_042 MSKTGLVLVVLYLLFSPVNLQQNEDDQAFFKIESPTLTR VLRGCHNCKTDSNGFCAGTCCNASFTCQ-GGSLGCGCRMMTDNYGQTTS- A_0239_383 MSKTGLVLVVLYLLFSPVNLQQNEDDQAFFKIESPTLTR VLRGCHNCKTDSNGFCAGTCCNASFTCQ-GGSLGCGCRMMTDNYGQTTS- A_0031_238 MSKTGLVLVVLYLLFSPVNLQQNEDDQAFFKIESPTLTR VLRGCHNCKTDSNGFCAGTCCNASFTCH-GGSLGCGCRMMTDNYGQTTS- A_0875_070 MSKTGLVLIVLYLLSSPVNLQQNEDDQAFFKIESPTLTR VLRGCHNCEADSTGHCRGPCCNASFTCQ-ADHWGCGCVITTHNYGQTTSN A_0048_160 MSKTGLVLVVLYLLSSPVNLQQNEDDQAFFKIESPTLTR VLRGCHNCEADSTGHCRGPCCNASFTCQ-ADHRGCGCVITTHNYGQTTSN A_0025_350 MSKTGLVLVVLYLLSSPVNLQQNKDDQAFFKIESPTLTR VLRGCHNCEADSTGHCGGPCCQASFTCQ-AANGGCACVITTHNYGLTTSN ermineusAXL95455 MSKTGLVLVVLYLLSSPVNLQQNEDDQAFFKIESPTLTR VLRGCHNCEADSTGHCGGPCCQASFTCQ-AANGGCACVITTHNYGLTTSN A_0875_069 MSKTGLVLIVLYLLSSPVNLQQNEDDKAFSEIKSPTLSR DQPGCFNCFPDGKGYCVGTCCE-SETCKHGINHDCGCLKD---------- A_0055_040 MSKIGLVLVVLYLLSSPVTLQQNEDDKASSEIKSPTLSR DRPACFNCFPNGKGHCVGTCCE-SETCKHGINHDCGCLKD---------- A_0239_384 MSKTGLVLVVLYLLFSPVNLQQNEDDKAFSEIKSPTLSR DRPACFNCFPNGKGHCVGTCCE-SETCKHGINHDCGCLKD---------- A_0031_237 MSKTGLVLVVLYLLFSPVNLQQNEDDKAFSEIKSPTLSR DRPACFNCFPNGKGYCVGTCCE-SETCKHGINHDCGCLKD---------- A_1387_184 MSKTGFVLVVLYLLFSPVNLQQNEDDKAFSEIKSPTLSR DRPACFNCFPNGEGHCVGTCCE-SETCKHGINRECGCLKD---------- A_0039_014 MSKIGLVLVVLYLLSSPVTLQQNEDDKASSEIKSPTLSR DRPACFNCFPNGKGHCVGTCCE-SKTCKHGINHDCGCLKD---------- A_0885_034 MSKIGLVLVVLYLLSSPVTLQQNEDEEAVSKIKIALTSR ERPACYKCFPNENGHCVGTCCE-SAICK-MTVLGCGCA------------ A_0885_036 MSKTGLVLVVLYLLFSPVNLQQNEDDKAFSEIKSPTLSR DRPACFNCFPNGKGHCVGTCCE-SAICK-MTVLGCGCA------------ V_1258_071 MSKIGLVLVVLYLLSSPVNLQQNEDDKAFSEIKSPTLSR ARPECYKCFANENGHCVGTCCE-SDTCK-GTIRGCGCP------------ V_CG13_032 MSKIGLVLVVLYLLSSPVNLQQNEDDKAFSEIKSPTLSR ARPECYKCFPNENGHCVGTCCE-SDTCK-GTIRGCGCV------------ V_1302_018 MSKIGLVLVVLYLLSSPVNLQQNEDDKAFSEIKSPTLSR ARPECYKCFANENGHCVGTCCE-SDTCK-GTIRGCGCV------------ V_1258_070 MSKIGLVLVVLYLLSSPVNLQQNEDDKAFSEIKSPTLSR ARPECYKCFANENGHCVGTCCE-SDTCK-GTIRGCGCV------------ milesAKB91382 MSKTGLVLVVLYLLSSPVNLQQNEDDQAFSKIE----TR DRPECYNCFPNDDGHCVGTCCG-EDSCK-GGIRGCGCV------------ A_0885_035 MSKTGLVLVVLYLLFSPVNLQQNEDDKAFSEIKSPTLSR GRPECYNCFPNSKGICVGTCCKTSETCR-GSYRGCGCL------------ A_0055_041 MSKIGLVLVVLYLLSSPVTLQQNEDDKASSEIKSPTLSR GRPECYNCFPNNDGICVGTCCKTSETCR-GSIRGCGCL------------ A_0031_239 MSKIGLVLVVLYLLSSPVTLQQNEDDKASSKIKSPTLSR GRPECYNCFPNDDGICVGTCCKTSETCR-GSIRGCGCL------------ A_0039_013 MSKIGLVLVVLYLLSSPVTLQQNEDDKASSEIKSPTLSR GRPECYNCFANEDAICVGTCCKTSETCR-GSNRGCGCL------------ A_0855_037 MSKIGLVLVVLYLLSSPVTLQQNEDDKASSEIKSPTLSR GRPECYNCFANEDAICVGTCCKTSETCR-GSNRGCGCL------------ A_0520_085 MSKIGLVLVVLYLLSSPVTLQQNEDDKASSEIKSPTLSR GRPECYNCFANEDAICVGTCCKTSETCR-GSNRGCGCL------------ A_0048_161 MSKIGLVLVVLYLLSSPVTLQQNEDDKASSEIKSPTLSR GRPECYNCFANEDAICVGTCCKTSETCR-GSNRGCGCL------------ A_1387_185 MSKTGLALVVLYLLFSPVNLQQNEDDKAFSEIKSPTLSR GRPECYNCFPNDDGICVGTCCKTSETCR-GSNRGCGCL------------ A_1387_186 MSKTGFVLVVLYLLFSPVNLQQNEDDKAFSEIKSPTLSR GRPECYNCFPNDDGICVGTCCKTSETCR-GSNRGCGCL------------ praecellensATF27774 MSKTGLVLVVLYLLSSPVNLQQNEDDKAFMKIMIPTLTR VLERSGSCSPQSGGGCTGTC---PGICE-GSRYGCACKTTG--------- andremeneziATF27527 MSKTGLVLVVLYLLSSPVNLQQTEDDKAFMKIMIPTLTR VLERSGSCVPKSGGGCTGTC---PGTCE-GSIKGCACKTTG--------- [Rmil Superfamily 02] [New Framework] [ /-------Signal------/------Pro-----/ /C---C--C-----CCC----C-----C--------] A_0031_039 MRFHLLLTVTLLLTSFT--DAGLLQAN---RHFVRR DCQTNCVACSNPAGCCCGNDRECKNDRCVP--KEL-- A_1387_062 MRFHLLLTVTLLLTSFTGGDAGLLQAN---RHFVRR DCQTSCVACSTPGGCCCGYTRECKKDKCVP--KEL-- V_CG13_009 MRFHLLLTVTLLLTSFTGGDAGLLQAN---RHFVRR DCQTNCVACDNPAGCCCGNNRECRNKRCVL--KE--- V_1302_017 MRFHLLLTVTLLLTSFTGGDAGLLQAN---RHFVRR DCQTNCVACDNPAGCCCGNNRECRNKRCVL--KE--- K_0010_258 MRCYLLLTVTLLLTSFAGGDAGPAQAN---RHFVRR DCQTGCVGCKNRAGCCCGTQVCVDGNRCEP--GK--- V_1278_017 MRFYLLLTVTLLLTSFSGADAGPRRANGLEKHFVSR DCQTGCVGCHNRAGCCCGDLVCVDDDHCEP--RSR-- V_1258_020 MRCYLLLTVTLLLTLFTGGDAGPRRANGLEKHFVRR DCQTGCVGCHNRAGCCCGDLVCVDDDHCEP--RSR-- V_1278_016 MRFYLLLTVTLLLTSFSGADAGPRRANGLEKHFVRR DCQWGCHGCANPAGCCCGDLVCVDDDHCEP--RSR-- V_CG13_008 MRFYLLLTVTLLLTSFSGADAGPRRANGLEKHFVRR DCQWGCHGCANPAGCCCGDLVCVDGDHCET--RSL-- V_1302_016 MRFYLLLTVTLLLTSFSGADAGPRRANGLEKHFVRR DCQWGCHGCANPAGCCCGDLFCVDGDHCET--RSL-- A_0055_352 -------------------DAGPRRANGLEKHFVRR DCGRHCVGCDNKNGCCCGNLVCGESNRCEP--SSL-- A_0048_037 MRFYLLLTVTLLLTSFTGADAGPRRANGLEKHFVRR DCQRGCVGC---------------------------- A_0885_157 MRFYLLLTVTLLLTSFTGADAGPRRANGLEKHFVRR DCQRGCVACHNPAGCCCGDLVCVDDYRCEP--RSL-- A_0055_103 MRFYLLLTVTLLLTSFTGADAGPRRANGLEKHFVRR DCQSGCVGC---------------------------- A_1387_064 MRFYLLLTVTLLLTSFTGADAGPRRANGLEKHFVRR DCQSGCVGCHNPAGCCCGDLVCVDDNHCEL--RSL-- A_0055_102 MRFYLLLTVTLLLTSFTGADAGPRRANGLKKRFVRR DCQSGCVGCHNSAGCCCGDLVCIDYNHCEP--RSL-- A_0239_031 MRFYLLLTVTLLLTSFTGADAGPRRANGLEKHFVRR DCQSGCVGCNNRAGCCCGGQVCVDYNHCEKRPPSF-- A_0239_032 MRFYLLLTVTLLLTSFTGADAVPRRANGLKKRFVRR DCQSGCVGCHNSAGCCCGDLVCIDYNHCESRPRSL-- V_1258_019 MRCYLLLTVTLLLTLFTGGDAGPRRANGLEKHFVRR DCQTGCVGCSNPAGCCCGELICVNGNHCESRSDYIII K_0010_260 MRCYLLLTVTLLLTLFTGGDAGPRRANGLE------ ---------NNPAGCCCGELICVNGNHCESSSNYIII K_0010_261 MRCYLLLTVTLLLTLFTGGDAGPRRANGLEKHFVRR DCQSGCVGCSNPAGCCCGELICVNGNHCESSSNYIII betulinusALM87510 MRFYLLLTATLLLTLFTGGDAGPRRANWLGRHFVSR DCQATCVGCHNPAGCCCGELICVNNNHCEPRPESL-- magusQFQ61148 MRFYLLLTVTLLLTLSTGGDAGPRRANGLPKHFVLR TCTGNCRLC--GAICCCEPKVC-RNNQCIY-DK---- milesA0A0E3SVB8 MRFFFLLLTVALFLTSITGDDAERMLGMKEGGYVRE DCGSDCAPC--GGECCCEPNSC-IDGTCHH-ESSPN- [Tand Superfamily 01] [New Framework] [ /---------Signal----------/---C------C------C-----------C---C-C-----C---------------------C--------C---------------------C-C-------------C-----] V_1278_035 MKSAVLMMALSMSIFIDFTM-ESATP-DVPCSVPDELCTTTGGTCGEYYHWSGRNYCFRFCECDIGMGCPTDEAHAIIRGNVTHPLTHYTCQPISEFTACKVNDVAMVTP--GPGLLRVVKCLCPWM--YTYDGNASYICKD-- A_0875_009 MKSAVLMMALSMSILIDFTI-ESATP-DGPCSDPYELCTTTGGTCGEYYHWSGRNYCFRFCECDIGMGCPTDEAHAIIRGNVTHPLTHYTCQPISEFTACKVNDVAMLTP--GPGLLRVVKCLCPWV--YTYDGNASYICKD-- A_0039_035 MKSAVLMMALSMSILIDFTI-ESATP-DGPCSDPYELCTTTGGTCGEYYHWSGRNYCFRFCECDIGMGCPTDEAHAIISGNVTDPLTHYTCQPISEFTACKVNDVAMLIP--GPGLLRVVKCLCPWV--YTYDGNASYICKD-- V_CG13_083 MKSAVFMMALSMSILIDFTM-ESATP-DVPCSVPDELCTTTGGTCGEYYHWSGSNYCFRFCECDIGMGCPTDEAHAIIRGNVTQPLTHYTCQPISEFTACKVNDVAMLTT--GHGLLRVVKCLCPWV--YTYDGNASYICKD-- A_0885_005 MKSAVLMMALSMSILIDFTI-ESATP-DGPCSVPNKLCNTTGGTCGEYYHWSGRNYCFRFCECDIGMGCPTDEAHAIIRGNVTHPLTHYTCQPISEFTACKVNDVAMLNP--DLGLLLVVKCLCPWV--YTYDGNGSYICKD-- A_1387_201 MKSAVLMMALSMSILIDFTI-ESATP-DGPCSDPYELCTTTGGTCGEYYHWSGRNYCFRFCECDIGMGCPTDEAHAIIRGNVTHPLTHYTCQPISEFTACKVNDVAMLTP--GPGLLRVVKCLCPWV--YTYDGNASYICKD-- A_0520_065 MKSAVFMMALSMSILIDFTI-ESATP-DGPCSDPYELCTTTGGTCGEYYHWSGRNYCFRFCECDIGMGCPTDEAHAIIRGNVTHPLTHYTCQPISEFTACKVNDVAMLNP--GPGLLMVVKCLCPWV--YTYDGNASYICKD-- A_0239_269 MKSAVFMMALSMSILIDFTI-ESATP-DGPCSDPYELCTTTGGTCGEYYHWSGRNYCFRFCKCDIGMGCPTDEAHAIIRGNVTHPLTHYTCQPISEFTACKVNDVAMLNP--GPGLLLVVKCLCPWV--YTYDGNGSYICKD-- A_0031_145 MKSAVLMMALSMSILIDFTI-ESATP-DGPCSDPYELCTTTGGTCGEYYHWSGRNYCFRFCECDIGMGCPTDEAHAIIRGNVTHPLTHYTCQPISEFTACKVNDVAMLNP--GPGLLLVVKCLCPWV--YTYDGNGSYICKD-- A_0025_060 MKSAVLMMALSMSILIDFTI-ESATP-DGPCSDPYELCTTTGGTCGEYYHWSGRNYCFRFCECDIGMGCPTDEVHAIIRGNVTHPLTHYTCQPISEFTACKVNDVAMLNP--GPGLLLVVKCLCPWV--YTYDGNGSYICKD-- A_0239_272 MKSAVFMMALSMSIFIDFTM-ESATP-DVPCSVPDELCTTTGGTCGLFYRFGGRNYCFRFCKCDIGMGCPTDEAHAIIRGNVTHPLTHYTCQPISEFTACKVNDVAMLNP--GPGLLLVVKCLCPWV--YTYDGNGSYICKD-- A_0055_091 MKSAVFMMALSMSIFIDFTM-ESATP-DVPCSVPDELCTTTGGTCGLYFRRRGRNHCFRFCECNIGMGCPTDEAHAIVSGNVTDPLTHYTCQPISEFTACKMNDVAIVTP--GPGLLRVVKCICPWV--YANDGSGTYICKE-- A_0855_004 MKSAVFMMALSMSIFIDFTM-ESATP-DVPCSVPDELCTTTGGTCGLYFRRRGRNHCFRFCECNIGMGCPTDEAHAIVSGNVTDPLTHYTCQPISEFTACKMNDVAIVTP--GPGLLRVVKCICPWV--YANDGSGTYICKE-- A_0520_066 MKSAVFMMALSMSIFIDFTM-ESATP-DVPCSVPDELCTTTGVTCGLYFRRRGRNHCFRFCECNIGMGCPTDEAHAIVSGNVTDPLTHYTCQPISEFTACKMNDVAIVTP--GPGLLRVVKCICPWV--YANDGSGTYICKE-- A_0239_268 MKSAVFMMALSMSIFIDFTM-ESATP-DVPCSVPDELCTTTGGTCGLYFRRRGRNHCFRFCECNIGMGCPTDEAHAIVTGNVTDPLTHYTCQPISEFTACKMNDVAIVTP--GPGLLRVVKCICPWV--YANDGSGTYICKE-- A_0048_185 MKSAVFMMALSMSIFIDFTM-ESATP-DVPCSVPDELCTTTGGTCGLYFRRRGRNHCFRFCECDIGMGCPTDEAHAIVSGNVTDPLTHYTCQPISEFTACKMNDVAIVTP--GPGLLRVVKCICPWV--YANDGSGTYICKE-- A_0239_270 --SAVFMMALSMSIFIDFTM-ESATP-DVPCSVPDELCTTTGGTCGLFYRFGGRNYCFRFCKCDIGMGCPTDEAHAIVTGNVTDPFTYYTCQPISEFPVCNVNDVAIVIPEHGHPLLHEVKCICPWV--YANDGSGTYICKE-- A_0239_273 MKSAVFMMALSMSIFIDFTM-ESATP-DVPCSVPDELCTTTGGTCGLFYRFGGRNYCFRFCKCDIGMGCPTDEAHAVVTGNVTDPFTYYTCQPISEFPVCNVNDVAIVIPEHGHPLLHEVKCICPWV--YANDGSGTYICKE-- A_0031_146 MKSAVFMMALSMSIFIDFTM-ESATP-DVPCSVPDELCTTTGGTCGLFYHFGGRNYCFRFCECDIGMGCPTDEAHAVVSGNVTDPFTYYTCQPISEFPVCNVNDVAIVIPEHGHPLLHEVKCICPWV--YANDGSWTYICKE-- K_0010_034 MKSAVFMMALSMSIFIDFTM-ESATP-DVPCTDTDKLCTTFGGTCGEYYHWSGSNYCFRFCKCDVGMGCPTDEAHAIVRGTVTHPFTHYTCQPISEFPVCKVHDVAIVNS--GPALPRVVKCICPWV--YAYDGNVSHICK--- A_0875_010 MKSAVLMMALSMSILIDFTI-ESATP-DGPCSDPYELCTTTGGTCGEYYHWSGRNYCFRFCECDIGMGCPTDEAHAIIRGNVTHPLTHYTCQPISEFPECNVNDVAIVIPEHGHPLLREVKCICRGV--YAYDDNVTHFSKD-- A_0055_094 MKSAVFMMALSMSIFIDFTM-ESATP-DVPCRVPDELCTTTGGTCGLYYHWRGRNYCFRFCKCDIRMGCPTDEAHAIVSGNVTDPFTYYTCQPISEFPVCNVNDVAIVIPEHGHALLREVKCICRGV--YAYDDNVTHFCKD-- A_0039_036 MKSAVFMMALSMSIFIDFTM-ESATP-DVPCSVPDELCTTTGGTCGLYYHWRGRNYCFRFCKCDIRMSCPTDEAHAIISGNVTDPFTYYTCQPISEFPVCNVNDVAIVIPEHGRALLREVKCICRGV--YAYDDNVTHFCKD-- A_0520_064 MKSAVFMMALSMSIFIDFTM-ESATP-DVPCSVPDELCTTTGVTCGLYFRRRGRNHCFRFCECNIGMGCPTDEAHAIVSGNVTDPLTHYTCQPISEFPVCNVNDVAIVIPEHGHPLLREVKCICRGV--YAYDDNVTHFCKD-- A_1387_200 MKSAVLMMALSMSIFIDFTM-ESATP-DVPCSVPDELCTTTGGTCGLYYHWRGRNYCFRFCECDIGMGCPTDEAHAIVSGNVTDPFTYYTCQPISEFPVCNVNDVAIVIPEHGHALLREVKCICRGV--YAYDDNVTHFCKD-- A_0048_186 MKSAVFMMALSMSIFIDFTM-ESATP-DVPCSVPDELCTTTGGTCGLYYHWRGRNYCFRFCECDIGMGCPTDEAHAIVSGNVTDPFTYYTCQPISEFPVCNVNDVAIVIPEHGHPLLREVKCICRGV--YAYDDNVTHFCKD-- A_0048_184 MKSAVFMMALSMSIFIDFTM-ESATP-DVPCSVPDELCTTTGGTCGLYYHWRGRNYCFRFCKCDIRMGCPTDEAHAIVSGNVTDPFTYYTCQPISEFPVCNVNDVAIVIPEHGHPLLREVKCICRGV--YAYDDNVTHFCKD-- V_1302_065 MKSAVLMMALSMSIFIDFTM-ESATP-DVPCSVPNKLCTTTGGTCGEYYHWSGSNYCFRFCECDVGMACPIDEAHAIIRGNKTHPFTHYTCQPISEFPQCEVNDVAIVN---APAPYRVVKCICRGV--YAYDGNVSHICKE-- V_1258_035 MKSAVLMMALSMSIFIDFTM-ESATP-DVPCSVPNKLCTTTGGTCGEYYHWSGSNYCFRFCECDVGMACPIDEAHAIIRGNKTHPFTHYTCQPISEFPQCEVNDVAIVN---APAPYRVVKCICRGV--YAYDGNVSHICKE-- V_CG13_084 MKSAVLMMALSMSILIDFTM-ESATP-DVPCSVPNKLCTTTGGTCGEYYHWSGSNYCFRFCECDVGMACPIDEAHAIIRGNKTHPFTHYTCQPISEFPQCEVNDVAIVN---APAPYRVVKCICRGV--YAYDDNVSHICKE-- A_0048_167 --SAVFMMALSMSIFIDFTM-ESATP-QVLCSDADDSCSSLDETCGEYYRWGDDLYCFRFCNCDAGMNCPTNEDYAIVLGTLTDPWTLYTCNPIITFPECNVGDIAIDNV--GQS----------------------------- A_0239_271 MKSAVFMMALSMSIFIDFTM-ESATP-QVLCSDADDSCSSLDETCGEYYRWGDDLYCFRFCNCDAGMSCPTNEDYAIVLGTLTDPWTLYTCNPIITFPECNAGVFAIDNV--GQSF-RRVHCTCPGG--YEYNDDGSFFCRD-- V_1302_063 MKSAVFMMALSMSIFIDFTM-ESATP-QVLCSDADDSCSSLDETCGEYYRWGDDLYCFRFCNCDAGMSCPTNEDYAIVLGTLTDPWTLYTCNPIITFPECNAGDIAIDNV--GQSF-RRVHCTCPGG--YEYNDDGSFFCRD-- A_0025_061 MKSAVFMMALSMSIFIDFTM-ESATP-QVLCSDADDSCSSLDETCGEYYRWGDDLYCFRFCNCDAGMSCPTNEDYAIVLGTLTDPWTLYTCNPIITFPECNAGDIAIDNV--GQSF-RRVHCTCPGG--YEYNDDGSFFCRD-- andremeneziATF27517 MKSAVFMMALSMSISIVFTK-ESAIPPGTRCSDPKGTCPFTDGTCGAYYRSGNANYCFRVCKCKGTNDCLIDEDHALVRGNKTFPSTVFTCKPIREFRECKDGETALVYP--QPGLIRQIRCLCSRGWRYEYAGNGKVKCLRLT praecellensATF27767 MKSAVFMMALSMSISIVFTKAEESVVKGVDCSVPKGTCPFTDGTCGAYYYWGGAIHCFRVCKCEGTNDCLIDEDHALVRGNKSFPDTVFTCKPIREFTECDNGDIALVYT--QPGLIGQILCLCSRGRRYEQAGSGIYKCFD-- magusQFQ61149 MRSAIFMMALSMSISIGFATEWKPPTVPCSEPVKQCPATDATCGTYYYWSVDNKNFCFLVCKCGDQNTCLTDEDHAIVLGNETHPNTIYTCKPISKIPECDKDKTTLLPL---GGLLMKVPCKCLGG--YQRLRDGSYKCR--- [Tpra Superfamily 06] [formerly Cerm Superfamily 13 in Abalde et al. 2018 GBE 10:2643–2662] [New Framework] [ /----Signal--------/ /--C------------C------C--------C---C-C-----C--------------------------C--------C-----------------------C-C-----------------C--------/] A_0885_292 ------------------- ---------------------------------------------CSTDSDHTITVVPHYVNYFPSKKRYYTCVALSGLDECSNGQISLRDIVPGTAELKYAEVLCNCRLPKVYTRL-IKPERYICALAPPLR--N V_1278_001 MLSMLAWTLMTAMVVMNAK SQ-FCPTMEDSYPDEHKCLYDNSLCGKEVS-GSCSSICYCRNLQMCSTDSDHTITVVPYYVNFYPVKKRYYTCVALSGLNECSGTQNALHDLVPETTELKHVEVLCKCPSPKVYLKV-LQPERFICAVAPRRS--G V_1302_009 MLSMLAWTLMTAMVVMNAK SQ-FCPTMTDSYRGEHECHYDNNLCGKEVS-GSCSSICYCRNLQMCSTDSDHTITVVPYYVNFYPVKKRYYTCVALSGLNECSGTQNALYDLVPETTELKHVEVLCKCPSPKVYLKV-LQPERFICAVAPRRS--G V_1258_016 ------------------- ----------SYPDEHKCLYDNSLCGKEVS-GSCSSICYCRNLQMCSTDSDHTITVVPYYVNFYPVKKRYYTCVALSGLNECSGTQNALHDLVPETTELKHVEVLCNCRSPKVYRRF-INPVRYICARARPLS--G V_1278_002 MLSMLAWTLMTAMVVMNAK SQ-FCPTMEDSYPDEHKCLYDNSLCGKEVS-GSCSSICYCRNLQMCSTDSDHTITVVPYYVNFYPVKKRYYTCVALSGLNECSGTQNALHDLVPETTELKHVEVLCNCRSPKVYKRI-INPVRYICARARPLS--G V_CG13_187 MLSMLAWTLMTAMVVMNAK SQ-FCPTMEDSYPDEHKCLYDNNLCGKEVS-GSCSSICYCRNLQMCSTDSDHTITVVPYYVNFYPVKKRYYTCVALSGLNECSGTQNALYDLVPETTELKHVEVLCNCRSPKVYRRF-INPVRYICAHAPPLS--G A_0048_263 MLSMLAWTLMTAMVVMNAK SQ-FCPTMEDSYPNEHKCFYDNNLCGKKVS-GSCSSICYCKNGKMCSTDGDHTITVVPYYENRHPVKKRYFTCVDLSGLEKCSKTETALFSLVPAATELKTAKVLCNCRSPKVYKRL-INPERYICALAPRLP--H A_0520_143 MLSMLAWTLMTAMVVMNAK SQ-FCPAMKNGYRDEHKCLRDNSLCGKEVS-GSCSSICYCRNLHMCSTDSDHTITVVPHYVNYYPVKKRYYTCVALSGLDECSNGQISLRDIIPGTAELKYAKVLCNCRSPKVYKRL-INPERYICALAPRLP--H A_0048_265 MLSMLAWTLMTAMVVMNAK SQ-FCPAMKNGYRDEHKCLRDNSLCGKEVS-GSCSSICYCRNLHMCSTDSDHTITVVPHYVNYYPVKKRYYTCVALSGLDECSNGQISLRDIIPGTAELKYAKVLCNCRSPKVYKRL-INPERYICALAPRLP--H A_0025_109 MLSMLAWTLMTAMVVMNAK SQ-FCPAMKNGYRDEHKCLRDNSLCGKEVS-GSCSSICYCRNLHMCSTDSDHTITVVPHYVNYYPVKKRYYTCVALSGLDECSNGQISLRDIIPGTAELKYAKVLCNCRSPKVYKRL-INPERYICALAPRLP--H A_0031_040 MLSMLAWTLMTAMVVMNAK SK-FCPTMEDGYDDEHRCLHDNSLCGKEVS-GSCSSICYCRNLQMCSTDSDHTITVVPRYVNYYPVKKRYYTCVALSGLNECSNGQTSLRDIVPDTAELKYAEVLCNCRLPKVYRRF-INPERYICALAPPQP--H A_0875_074 MLSMLAWTLMTAMVVMNAK SQ-FCPTMEDRYPDEHKCFYDNNLCGKKVS-GSCSSICYCKNGKMCYTESDHTITVVPYYVYHHPVKMRYYTCVALSGLEECSNDETALYNLVPIAAELKTAKVLCKCPSPKVYLST-GRNQRYICARAPPLK--G A_0855_140 MLSMLAWTLMTAMVVMNAK SQ-FCPTMEDRYPDEHKCFYDNNLCGKKVS-GSCSSICYCKNGKMCYTESDHTITVVPYYVYHHPVKMRYYTCVALSGLEECSNDETALYNLVPNAGELKTAKVLCKCPSPKVYLST-GRNERYICARAPPLN--G A_0055_038 MLSMLAWTLMTAMVVMNAI SQ-FCPTMEDSYADEHKCFYDNNLCGKKVS-GSCSSICYCKNGKMCSTDGDHTITVVPYYENRHPVEKRYHTCVALSGLEECSNDETALYNLVPDAAELKTAKVLCKCPSPKVYLNT-GRNQRYTCAHAPPLN--G A_0055_037 MLSMLAWTLMTAMVVMNAI SQ-FCPTMEDSYADEHKCFYDNNLCGKKVS-GSCSSICYCKNGKMCSTDGDHTITVVPYYENRHPVEKRYHTCVALSGLEECSNDETALYNLVPDAAELKTAKVLCKCPSPKVYLNT-GRNQRYTCAHARKFF--V A_0239_291 MLSMLAWTLMTAMVVMNAK SQ-FCPTMEDSYPDEHKCFYDNNLCGKKVS-GSCSSICYCKNGKMCSTDDDHTITVVPYYENRHLVKKRYHTCVALSGLEECSNGETALYNLVPDAAELKTAKVLCKCPSPKAYLNT-GKNQRYTCGRASP----- A_0239_292 MLSMLAWTLMTAMVVMNAK SQ-FCPTMEDGFDFEHRCFYDNNLCGKKVS-GSCSSICYCKNGKMCSTDDDHTITVVPYQENRHPVKKRYHTCVALSGLEECSNGETALYNLVPDAAELKTAKVLCKCPYPKAYLNT-GKNQRYTCGRASP----- K_0010_426 MLSMLAWTLMTAMVVMNAK SQ-NCPAMSDSYHLEHECQYDNNLCGKEVS-GSCSSICNCKNGQTCSTDIDHSITVVKRYINRFPEKKRYYTCVALSELNECSGTQKALYDLIPENPALKHVEIFCKCRPPKVYRYL-WNSHDYICALVPPLR--K ermineusAXL95365 MLSMLAWTLMTAMVVMNAK SQ-FCPVLTDSYRFEHRCAYDNSLCGKEVS-GSCTSTCYCRSGRMCLRNSDHTITVVKRYINNNPVKESYHTCVALSGLPRCSGNRVALYNLVPESSAFKSVEVRCRCPSPNVYLNT-GLNQVYTCAPAPQLNVVG gloriamarisGFNK01000105 MLSMLAWTLMTAMVVMNAK SDTTCPTSTNIV----SCVNDNDACGKDVS-GSCSSICNCKNGQTCSTDSNHTIILVPYYTEYGPYIKNYYTCVDPSDLDGCSIAQKSVNVSVSEAEDPNSVEVLCYCPPSKINIWA-VNFQYYLCTTPPQPD--S praellescensATF27771 MLLMFAWTLMTAMMVMNAS SK-DCPLLDDSNPLKRRCLWNNAICGKSVS-GKCTSLCNCRNGQKCSMNSTHTITVVPYYINGVPVKKRYYTCMDVAELGQCSSTQEALYSLIYEETELKNAKVYCECRSPKVYLRL-FTPKRYICRRAEPRT--G ############################################################################################################################################################################################################ New conotoxin precursor superfamilies [Unassigned Superfamily 01] [Framework XIII] [ /-----Signal-----/------Pro------/ /-----------C---C---C-------CC----C----------C--------] A_0239_387 MNCLQPLLVLLLISTITALYRDGRATQRRGRNTR TMSNLLNILKRQCPYGCPVSCPSGRSSECCNGIVCSYNDSLNKYFCIGCGGGGGE V_1278_025 ------------------------ATPRRGGDIR AMSNLLNILKRRCSSDCVSYCPG--GSGCCDGDVCSYNSNLKKWFCIGCGSGGGE V_CG13_137 MNCLQPLLVLLLISTITALYPDDRATPRRGGDIR AMSNLLNILKRQCPSDCVPYCPG--GSGCCDGDVCDYDRKLQKWFCIGCGGGGGE V_1302_072 MNCLQPLLVLLLISTITALYPDGRATPRRGGDIR AMWNTLNIQTRECSPDCVPYCPG--GSGCCDGDACSYDIEFDKWFCIGCGSGGGE V_1302_073 MNCLQPLLVLLL----TALYQDGRATPRRGGDIR AMWNTLNIQTRECSPDCVPYCPG--GSGCCDGDACSYDIEFDKWFCIGCGSGGGE A_0031_307 MNCLQPLLVLLL----TALYQDGRATPRRGGDIR AMWNTLNIQTRECSPDCVPYCPG--GSGCCDGDVCSYDNEFDKWFCIGCGSGGGE A_0055_364 -------------------------TPRRGRTIR TMSNLLNILKRECSLDCVPHCPN--RNECCDGDVCSYNGSLDKWFCIGCGSGGGE A_0239_388 MNCLQPLLVLLLISTITALYRDGRATQRRGRNTR TMSNLLNIQTRVCPYDCPVKCPN--LSECCSGVSCARINPGGDYYCIGCGGGGGE A_0031_306 MNCLQPLLVLLLISTITALYRDGRATQRRGRNTR TMSNRLNIQTRVCPYDCPVKCPN--LSECCSGVSCARINPGGDYYCIGCGGGGGE A_1387_069 MNCLQPLLVLLLISAITALYQDDRATPRRGRTIR TMSNLLNILKRECSPDCVPHCPN--RNECCYGDVCSYNGSLEKWFCIGCGSGGGE A_0885_105 MNCLQPLLVLLLISAITALYRDDRATPRRGRTIR TMSNLLNILKRECSPDCVPHCPN--RNECCDGDVCSYNGSLDKWFCIGCGSGGGY A_0039_099 MKCLQPLLVLLLISAITALYQDDRATPRRGRTIR TMSNLLNILKRECSLDCVPHCPN--RNECCDGDVCSYNGSLDKWFCIGCGSGGGE V_1302_071 ---------------------------------R TMSNLLNILKRECPYGCPVKCPN--RNECCDGITCSTINPGSEYYCIGCGGGGGE V_1278_026 ---------------------------------R AMSNLLNILKRECPSGCPVKCPN--RNECCDGITCSTINPGSEYYCIGCGGGGGE A_0055_155 --------------AITALYRDGRATQRRGRNIR TMSNLLNIQTRECPYGCPVKCPN--RNECCSGVTCTFINPGGDYYCIGCGGGGGE A_1387_070 MNCLQPLLVLLLISTITALYRDGRATQ-RGRNTR TMSNLLNIQTRECPYGCPVKCPN--RNECCSGVTCTYINPGGDYYCIGCGGGGGE V_CG13_138 ---------------------------------- ---NLLNILKRECPSGCPVKCPN--GNECCSGITCSTINPGSEYYCIGCGGGGGE A_0520_302 MKCLQPLLVLLLISAITALYRDGRATQRRGRNTR TMSNLLNIQTRECPYGCPVKCPN--RNECCSGVTCTYIYPGGDYYCIGCGGGGGE A_0875_139 M------LVLLLISAITALYRDGRATQRRGRNTR TMSNLLNIQTRECPYGCPVKCPD--RNECCSGVTCTYIYPRSDYYCIGCGGGGGE A_0885_106 MNCLQPLLVLLLISAITALYRDGRATQRRGRNTR TMSNLLNIQTRECPYGCPVKCPD--RNECCDGITCTQTYQGSDYYCIGCGGGGGE A_0055_148 MKCLQPLLVLLLISAITALYRDGRATQRRGRNIR TMSNLLNIQTRECPYGCPVKCPD--RNECCDGITCTQTYQGSDYYCIGCGGGGGE A_0039_098 MKCLQPLLVLLLISAITALYQDGRATQRRGRNTR TMSNLLNIQTRECPYGCPVKCPD--RNECCDGITCTQTYQGSDYYCIGCGGGGGE K_0010_263 ---------------------------------- -MSNRLNIQTRECPYGCPVSCPGGSSNECCSGITCSWNSAVSKYFCAGCGGGGGE K_0010_264 MNCLQPLLVLLLISTITELYQDGRATQRRARNIR TISNLLNTQTRECPTGCPVKCPD--RNECCSGITCTYNTPGGDYYCIGCGGGGGE betulinusALM87492 MNCLQPLLVLLLISAITALYQDGRETPRRGRNIR TMSNLLNIPKRQCPSGCPVKCPD--RNECCSGITCTYTTPGGDYYCIGCGGGGGE [Unassigned Superfamily 02] [Framework VI/VII] [ /------Signal------/--------Pro--------//C-------C-----CC---------C---C] A_1387_172 MSGTMIVLLAVLLLVDLSTSLQDPGEKLLRGIVKVEERKK CRTNHNSDCPEGEYCCGLPHESHGNCNRNC A_0885_009 MSGTMIVLLAVLLLVDLSTSLQDPGEKLLRGIVKVEERKK CRTNHNRDCPEGEYCCGLPHESHGNCYRNC A_0055_109 MSGTMIVLLAVLLLVDLSTSLQDPGEKLLRGIVKVEERKK CKTNHNSDCPEGEYCCGLPHESHGNCYRNC A_0520_073 MSGTMIVLLAVLLLVDLSTSLQDPGEKLLRGIVKVEERKK CRTNHNRDCPEGEYCCGLPHESHGNCYRNC A_0239_265 MSGTMIVLLAVLLLVDLSTSLQDPGEKLLRGIVKVEERKK CKTNHNSDCPEGEYCCGLPHESHGNCYRNC betulinusAMP44703 MSGTMIALLAVLLLVDLSTSLQDQGEKLLRGTVKVQERER CRTNHNSDCPMGQYCCGLPHWSHGYCQRAC [Unassigned Superfamily 03] [Framework VI/VII] [ /------Signal---------/------------Pro------------/ /--C---------C-----CC---------C-----C------] A_0039_101 MPGSRVALLAFLLLLSLVTSVQGGGEGQTMYQDKHRQRVRKLYTLGRTLKR NDPCSLISSTGDDCTGTQICCTPPGSMSGECKEANEC------- A_0048_004 MPGSRVALLAFLLLLSLVTSVQGGGEGQTMYQDKHRQRVRKLYTLGRTLKR NDPCSLISSTGDDCTGTQICCTPPGSMSGECKEANEC------- A_0025_112 MPGSRVALLAFLLLLSLVTSVQGGGEGQTMYQDEHRQRVRKLYTLGRKLKR NDPCSLISSTGDDCTGTHICCTPPGSMSGECKEANEC------- A_0875_030 MPGSRVALLAFLLLLSLVTSVQGGGEGQTMYQDKHRQRVRKLYTLGRKLKR NDPCNLIPSTGDDCTGTQICCIPSGWTSGECKEQNECQS-NS-R A_0855_005 MPGSRVALLAFLLLLSLVTSVQGGGEGQTMYQDKHRQRVRKLYTLGRKLKR NDPCSLISSTGDDCTGTQICCTPPGSMSGECKEGNECQSLNS-R A_0031_262 MPGSRAALLAFLLLLSLVTSVQGGGEGQTMYQDKHRQRERKLYTLGRKLKR NDPCELISSTGDDCTGTQICCTPPRSMSGECKEANECKSLSS-R A_1387_193 MPGSRVALLAFLLLLSLVTSVQGGGEGQTMYQDKHRQRVRKLYTLGRKLKR NDPCSLISSTGDDCTGTQICCTPPRELNGECKEADDCQYLNP-Q A_0055_039 MPGSRVALLAFLLLLSLVTSAQRGGEGQTMYQDKHRQRVRKLYTLGRKLKR YDPCFLISSTGDDCTGTQICCTPPWSMSGECKEANECLLILNDQ A_0239_257 MPGSRVALLAFLLLLSLVTSAQRGGEGQTMYQDKHRQRVRKLYTLGRKLKR YDPCFLISSTGDDCTGTQICCTPPWSMSGECKEANECLLILNDQ A_0520_016 MPGSRVVLLTFLLLLSLVTNLQGGGEGQTMYQDKHRQRVRKLYTLGRKLKR NDPCSLISPTGDDCTGTQICCTPPGSMSGECKEGNEC------- V_1258_102 MPGSRVALLAFLLLLSLVTNLQGGGEGQTMYQDKHRQRVRKLYTLGRKLKR NDPCELISPTGDDCTGTQICCAPRGSMSGECKEANECYT--S-R A_0885_159 MPGSRVVLLTFLLLLSLVTNLQGGGEGQTMYQDKHRQRVRKLYTLGRKLKR NDPCSLISPTGDDCTGTQICCTPSGWTSGECKEQNECQS-NS-R V_CG13_204 MPGSRVALLAFLLLLSLVTNLQGGGEGQTMYQDKHRQRVRKLYTLGRKLKR NDPCELISPTGDDCTGTQICCAPRGSMSGECKEANECQSLNS-Q V_1302_062 MPGSRVALLAFLLLLSLVTNLQGGGEGQTMYQDKHRQRVRKLYTLGRKLKR NDPCELISPTGDDCTGTQICCAPRGSMSGECKEANECQSLNS-Q K_0010_015 MPGSRVALLAFLLLLSLVTSLQGGGEGQTMYQDKHRQTVRKLFTLGRKLKR NDPCSLISSAGDDCTGTQVCCTPPGSMTGECKEGNEC------- betulinusALM87491 MPGSRVALLAFLLLLSLVTNLQGGGEGQTMYQDKHRQTMRKLSTLGRKLKR NDPCELDSPVGDDCTGTQICCTPPGSLSGECKETSECQ-LGR-R leopardusAIC77101 M--------FTVFLLSLMTNLQGGGEGQRMHQDKHRQTARKLFTLGRKVKR NDPCELDSPY-DDCTGTQICCTQPGSMSGECKEADEC------- [Unassigned Superfamily 04] [Framework VIII] [ /-------Signal--------/-----C--------C-------C---C--------C---C----------------C-----C---C---------C-----------------C] V_1258_266 ------------------------------------HCWLPEFRACLWDCWKMEVEDDCFAICTFAIAEEHGPDTDGFDCTIFKNCYGRCMAHGKSEPHCWEGTAATVTGDPEDLDTC V_CG13_126 MTMDMKMTFSGFVLVVLVTTVVGWPDSTCEVSDDLIHCWLPEFRACLWDCWKMEVEDDCFAICTFAIAEEHGPDTDGFDCTIFKTCYGRCMAHGKSEPHCWEGTAATVTGDPEDLDTC V_1302_179 MTMDMKMTFSGFVLVVLVTTVVGWPDSTCEVSDDLIHCWLPEFRACLWDCWKMEVEDDCFAICTFAIAEEHGPDTDGFDCTIFKNCYGRCMAHGKSEPHCWEGTAATVTGDPEDLDTC A_0855_089 MTMDMKMTFSGFVLVVLVTTVVGWPDPACEVSDDLIHCQLPEFRSCLWDCWTMEVEDDCFAICTLAIAEEHGQETDELDCTIFKTCYGRCMTLGKSESHCWEGTAETVTGDVTDLDTC A_0055_168 MTMDMKMTFSGFVLVVLVTTVVGWPDPACEVSDDLIHCQLPEFRSCLWDCWTMEVEDDCFAICTFAIAEEHGPETDEFDCTIFKTCYGRCMTLGKSESHCWEGTAETVTGDVTDLDTC A_0039_038 MTMDMKMTFSGFVLVVLVTTVVGWPDPACEVSDDLIHCQLPEFRSCLWDCWTMEVEDDCFAICTFAIAEEHGPETDEFDCTIFKTCYGRCMTLGKSESHCWEGTAETVTGDVTDLDTC A_1387_232 MTMDMKMTFSGVVLVVLVTTVVGWPDPACEVSDDLIHCQLPEFRSCLWDCWAMEVKDDCFAICTFAIAKEHGPETDEFDCTIFKTCYGRCVELGKSESHCWKGTAETVTGDVTDLEFC A_0520_193 MTMDMKMTFSGFVLVVLVTTVVGWPDPAFEVSDDLIHCQLPEFRSCLWDCWAIDVEGDCFAICTLAIAEEHGPETDEFDCTIFKTCYGRCVALGKTESHCWDETAETVTGKSTDLDTC A_0055_169 MTMDMKMTFSGFVLVVLVTTVVGWPDPACEVSDDLIHCQLPEFRSCVCDCRAIDEEDDCFAICTFAIAEEHGPETDDFDCTVFKTCYGRCMTLGKSESHCWEGTAETVTGDVTDLDTC A_0520_192 MTMDMKMTFSGFVLVVLVTTVVGWPDPAFEVSDDLIHCQLPEFRSCVCDCRAIDEEDDCFAICTFAIAKEHGPETDDFDCTVFKTCYGRCMTLEKSESHCWEGTAETVTGDVTDLETC A_0048_267 MTMDMKMTFSGFVLVVLVTTVVGWPDPAYEVSDDLIHCQLPEFRSCVCDCRAIDEEDDCFAICTFAIAKEHGPETDDFDCTVFKTCYGRCMTLEKSESHCWEGTAETVTGDVTDLETC V_CG13_127 -----------------------------EVSDNLIHCRLPEFRLCLLDCMSLN-KSACYHRCTIQTVQLFGSETIRYDCTVYKTCYHRCYVLGKTEPHCWEG--------------- V_1302_178 MTMDMKMTFSGFVLVVLVTTVVGSSIRRDEVSDNLIHCRLPEFRLCLLDCMSLN-KSACYHRCTIQTVQLFGSETIRYDCTVYKTCYHRCYVLGKTEPHCWEGTAGTVTGDVTDLDTC V_1258_028 MTMDMKMTFSGFVLVVLVTTVVGSSIRRDEVSDNLIHCRLPEFRLCLLDCMSLN-KSACYHRCTIQTVQLFGSETIRYDCTVYKTCYHRCYVLGKTEPHCWEGTAGTVTGDVTDLDTC V_1278_080 -----------------------------EVSDNLIHCRLPEFRLCLLECMSLN-KSACYHRCTIQTVQLYGSETIRYDCTVYKTCYHRCYVLGKTEPHCWEGTAGTVTGDVTDLDTC A_0039_039 MTMDMKMTFSGFVLVVLVTTVVGWPDPGNEVSDNLIHCQLPEFRLCLLECMSLN-KGACYDDCTIQTAQLYGHETIRYDCTVYKTCYHRCFVLGKTEHHCWEGTARTVTGKLIDLDTC A_0031_378 MTMDMKMTFSGFVLVVLVTTVVGWPDPGNEVSDNLIHCQLPEFRLCLLECMSLN-KGACYDDCTIQTAQLYGHETIRYDCTVYKTCYHRCFVLGKTEHHCWEGTARTVTGKLIDLDTC A_0239_421 MTMDMKMTFSGFVLVVLVTTVVGWPDPGNEVSDNLIHCQLPEFRLCLLECLSLN-KGACYDDCTIQTAQLYGSETITYDCTVYKTCYHRCFVLGKTEHHCWEGTARTVTGKLTDLDTC A_0055_170 MTMDMKMTFSGFVLVVLVTTVVGWPDTGNEVSDNLIHCQLPEFRLCLLECMSLK-KVACYDDCTIQTAQLYGSETIRYDCTVYKTCYHRCYVLGKTESHCWEGTATTVTGDVTDLDTC K_0010_031 --MDMKMTFSGFVLVVLVTTVVGSSVRRGEVSDNLSHCWLPEFRSCLWDCSTMGVEIDCFAGCTFAMADILGFETNRFDCTLFKTCYYRCYLLGKPEAHCWEAIAETVTGKPEDLNSC betulinusALM87517 MTMDMKMMFSGFVLIVCVTTVVGWPVLSTEVHDNLIHCRLPEFRVCLRVCWETGIEVDCYASCTYDVATEHGPKTEEFDCTVFKTCYGRCIELGKSEHHCWEGTARTVTGKVTDLDTC praecellensATF27577 MTMDMKMTFSGFVLVVLVTTVVGSSVRRGEVSDNLIHCWLPEFRECLLYCWSIELPVDCFATCTYVIGDIFGAQTESSDCAIFKTCYVRCMELGKSEDHCWEGIANTVTGAVGDLDTC andremeneziATF27384 MTMDMKMTFSGFVLVVLVTTVVGSSVRRGEVSDNLIHCWLPHFRECLLYCWSIELPVDCFATCTYVIGDIFGAQTESSDCTIFKTCYVRCMELGKSEDHCWEGIANTVTGAVGDLDTC [Unassigned Superfamily 05] [Framework XXII] [ /------Signal-------/-----C------------C-----C---C-----C-C------C-----C------] V_CG13_322 MMTLRHVLLFTLLLLPLATIRAETEC--------RNVSNCQEHTDCVTHCGPNYKCRCKPGTVRCPKGARCFLYD--- A_0885_004 ----------------------------------WVVQRCQKTSDCKPNCGTHFRCRCQPGTNRCPGDKGCFHSS--- V_CG13_059 MMTLRHVLLFTLLLLPLATIRADVYACVKRIESEWQVQRCRDDSECEPNCGTHFKCRCQPAANLCPGGAGCFHSS--- V_1302_089 MMTLRHVLLFTLLLLPLATIRADVYACVKRIESEWQVQRCKHDSECEPNCGTHFKCLCQPATNRCPGGEGCFHSS--- V_1278_014 MMTLRHVLLFTLLLLPLATIRADVYACVKRTGWEWKVQRCQKDPDCQPNCGTHFRCRCQPGANLCPGGTGCFHYS--- A_0039_199 MMTLRHVLLFTLLLLPLATIRADLYACVKKNGSNWVVQRCQKTSDCNPNCGTHFTCKCQPGTNLCSGGAGCFY-S--- A_1387_006 MMTLRHVLLFTLLLLPLATIRADVYACVKKIRSNWVVQRCQQTSDCNPNCGTHFTCKCQPGTNRCPGREGCFYYS--- K_0010_035 MMTLRHVLLFTLLLLPLATIRADVYGCLKWSSSAWQKTRCLNDTECESSCGTRFKCRCQPGINLCPGGPGCFHSS--- betulinusAMP44694 MMTLRHVLLFTLLLLPLATIRADTFACTKWIAPEWVVQRCREDSDCVPNCGTHFRCRCQPATNRCPGGAGCFYYIYNP [Unassigned Superfamily 06] [New Framework] [ /---------Signal------/--C-------C------C--------C---C-C-----C-----------------------C--------C------------------C-C---------------C-] A_0031_113 MLSVFTVVWVLTTAMMMTDVTFQSTCNTHNLTMCSEDTRLCGKRTPWNRCTGLCKCPNQQTCTTDTDHTVRIIRAPFDSIMTYYTCRNVSTMDACQSNETAMSGNSKETYKILCKCDKIYQPFSFDDWKHVCRE V_CG13_018 MLSVFTVVWVLTTAMMMTDVTFQSTCNTDNRTLCSEDTRLCGKRTPWSRCTGLCKCPNEQTCTTDTDHTVRIVRTPFDLTTTYYTCRNVSTMDACQSSETAMSGNSEETYKILCKCDKIYQPFSFDDWKHVCRE V_1278_093 MLSVFTVVWVLTTAMMMTDVTFQSTCNTDNRTLCSEDTRLCGKRTPWNRCTGLCKCPNEQTCTTDTDHTVRIVRTPFDLTTTYYTCRNVSTMDACQSSETAMSGNSKETYKILCKCDKIYQPFSFYDRKHVCR- V_1302_025 MLSVFTVVWVLTTAMMMTDVTFQSTCNTDNRTLCSEDTRLCGKRTPWNRCTGLCKCPNEQTCTTDTDHTVRIVRTPFDLTTTYYTCRNVSTMDACQSSETAMSGNSEETYKILCKCDKIYQPFSFDDWKHVCR- lenavatiJAI17775 MLFVFTVVWILTMVMIITDVTFQSTCNTDNKPSCSEDTRLCGKNNSWGNCVALCKCPNQQACTTDTDHKVQVKRGPFQLTETYYTCKNVSTMSDCQSNAKAMSGTSESTYKIMCKCDDTYKPSAPTNWKFICG- tribbleiJAI17897 MLFVFTVVWILTMVMIITDVTFQSTCNTDNKPSCSEDTRLCGKNNSWGNCVALCKCPNQQACTTDTDHKVQVKRGPFQLTETYYTCKNVSTMSDCQSNAKAMSGTSESTYKIMCKCDDTYKPSAPTNWKFICG- [Unassigned Superfamily 07] [Framework IX] [ /-------Signal----------/--C------------------------------------------------------------C------C------C--------------------------------------------------------------C-----------------------C-----] A_0875_006 MWSGK--AAFLALVLMVVGAHSTTAETCSPQRVHDSNFDTASGVWFLIFSGSGDERFVQSGLVVLSYYIGDRHLAAMTWFYSKRTTRGCELVTTRCEVIGKSCVYVTEGNQEVGKYYIIAQDKDYLVVYRTLSGHLHGLYIYSRTGVGQPFRNLPLGIRDAIGLTCGESYAETDTFWPGKYSPGNFSVNCKRGARK A_0855_111 MWSGKDQAAFLALVLMVVGAHSTTAEICSPQRVHDSNFDTASGVWFLIFSGSGDERFVQSGLVVLSYYIGDRHLAAMTWFYSKRTTRGCELVTTRCEVIGKSCVYVTEGNQEVGKYYIIAQDKDYLVVYRTLSGHLHGLYIYSRTGVGQPFRNLPLGIRDAIGLTCGESYAETDTFWPGKYSPGNFSVNCKRGARK A_0039_002 MWSGKDQAAFLALVLMVVGAHSTTAETCSPQRVHDSNFDTASGVWFLIFSGSGDERFVQSGLAVLSYYIGDRHLAAMTWFYSKRTTRGCELVTTRCEVIGKSCVYVTEGNQEVGKYYIIAQDKDYLVVYRTLSGHLHGLYIYSRTGVGQPFRNLPLGIRDAIGLTCGESYAETDTFWPGKYSPGNFSVNCKRGARK A_0055_213 MWSGKDQAAFLALVLMVVGAHSTTAETCSPQRVHDSNFDTASGVWFLIFSGSGDERFVQSGLAVLSYYIGDRHLAAMTWFYSKRTTRGCELVTTRCEVIGKSCVYVTEGNQEVGKYYIIAQDKDYLVVYRTLSGHLHGLYIYSRTGVGQPFRNLPLGIRDAIGLTCGESYAETDTLWPGKYSPGNFSVNCKRGARK A_0885_025 MWSGKDQAAFLALVLMVVGAHSTTAETCSPQRVHDSNFDTASGVWFLIFSGSGDERFVQSGFAVLSYYIGDRHLAAMTWFYSKRTTRGCELVTTRCEVIGKSCVYVTEGNQEVGKYYIIAQDKDYLVVYRTLSGHLHGLYIYSRTGVGQPFRNLPLGIRDAIGLTCGESYAETDTFWPGKYSPGNFSVNCKRGARK A_0520_022 ------------------------------------------GVWFLIFSGSGDERFVQSGLAVLSYYIGDRHLAAMTWFYSKRTTRGCELVTTRCEVIGKSCVYVTEGNQEVGKYYIIAQDKDYLVVYRTLSGHLHGLYIYSRTGVGQPFRNLPLGIRDAIGLTCGESYAETDTFWPGKYSPGNFSVNCKRGARK A_0025_431 ------------------------------------------------------------------------------WFYSKRTTRGCELVTTRCEVIGKSCVYVTEGNQEVGKYYIIAQDKDYLVVYRTLSGHLHGLYIYSRTGIGQPFRNLPLGIRDAIGLTCGESYAETDTFWPGKYSPGNFSVNCKRGARK A_0239_045 MWSGKDQAAFLALVLMVVGAHSTTAETCSPQRVHDSNFDTASGVWFLIFSGSGDERFVQSGLAVLSYYIGDRHLAAMTWFYSKRTTRGCELVTTRCEVIGKSCVYVTEGNQEVGKYYIIAQDKDYLVVYRTLSGHLHGLYIYSRTGVGQPFRNLPLGIRDAIGLTCGESYAETDTLWPGKYSPGNFSVNCKRGARK A_0031_046 MWSGKDQAAFLALVLMVVGAHSTTAETCSPQRVHDSNFDTASGVWFLIFSGSGDERFVQSGLAVLSYYIGDRHLAAMTWFYSKRTTRGCELVTTRCEVIGKSCVYVTEGNQEVGKYYIIAQDKDYLVVYRTLSGHLHGLYIYSRTGVGQPFRNLPLGIRDAIGLTCGESYAETDTLWPGKYSPGNFSVNCKRGARK K_0010_005 --------------------------------------------------------------------------------------------TTTCEVRDKSCVYTT-DANNVGKYYIIAQDENYLVVYKTLSGYLYGLYIYNRTGVGQPFRNLPLGIREAIALTCGDSYAETDTFWPGKYSPGDFLVNCNLGASK andremeneziATF27522 MWSGKDEAAFLALVLMVLWALGTTAESCSPDRIYYSDFEAASGVWYLILSRESDERYRVSGLDLNAYRYGGKLLVDVSWIFLKRTTRGCEKFTTRCEVSGNTCVDTT-GYHQVVKYYIVALDANYLVVHRTLQGNPYTLDIYSRTGVGRRLKHLPQYIRDAIEMTCGKDIATIDSFWPGKYSPGDFISNCF----- praecellensATF27761 MWNGKDQAAFLALVLMVAWALGTTAESCSPDRIYYSDFEAASGVWYLILSRESDERYRVSGLDLNAYRYGGKLLVDVSWIFLKRTTRGCEKVTTRCEVSGNTCVDTT-GYHQVVKYYIVALDANYLVVHRTLQGNPYTLDIYSRTGVGRRLKHLPQYIRDAIEMTCGKDIATIDSFWLGKYSPGDFISYCF----- ############################################################################################################################################################ Hormones [Conopressin / Conophysin-1] [New Framework] [ /---------Signal----------/C----------------------C---C---C-----CC----C---------C---------C------C-----------C-------CC----C-----C] A_0875_141 MTRSAMLMGRLTLVLCLLQLLLLTTQACFITNCPRGGKRDVDER-RSIKACMSCSFGQCVGPHICCGAGGCEMGTAKATKCSEEDDNPIPCQVHGDHCILNNPGNIHGHCVAD--GICCVNDTCAIHLGCL V_CG13_209 MTRSAMLMGRLTLVLCLLQLLLLTTQACFIRNCPNGGKRDVDERVHTPKPCMSCSFGRCVGPHICCGAGGCEMGTAEANRCSEENDDPIPCHVHGDQCALNNPGNNQGHCVAS--GICCVDDTCTTHPGCL V_CG13_208 MTRSAMLMGRLTLVLCLLQLLLLTTQACFIRNCPNGGKRDVDERVHTPKPCMSCSFGRCVGPHICCGAGGCEMGTAEANRCSEEDDDPIPCQVHGDQCTLNNPGNNQGHCVAS--GICCVDDTCTIHSECL V_CG13_206 MTRSAMLMGRLTLVLCLLQLLLLTTQACFIRNCPIGGKRDVDEG-HPTKACMSCSFGRCVGPHICCGAGGCEMGTAEANRCSEEDDDPIPCQVHGDQCTLNNPGNNQGHCVAS--GICCVDDTCTIHSECL A_0520_219 MTRSAMLMGRLTLVLCLLQLLLLTTQACFITNCPRGGKRDVDER-RSIKACMSCSFGQCVGPHICCGAGGCEMGTAEANRCSKEDDDPIPCQVLGDPCGPNNPGNNHGHCVAN--GICCVDDTCTTHPGCQ A_0048_090 MTRSAMLMGRLTLVLCLLQLLLLTTQACFITNCPRGGKRDVDER-RSIKACMSCSFGQCVGPHICCGAGGCEMGTAEANRCSKEDDDPIPCQVLGDPCGPNNPGNNHGHCVAN--GICCVDDTCTTHPGCQ A_0875_142 MTRSAMLMGRLTLVLCLLQLLLLTTQACFITNCPRGGKRDVDER-RSIKACMSCSFGQCVGPHICCGAGGCEMGTAEANRCSEEDDDPIPCEVLGDPCGPNNPGNNHGHCVAN--GICCVDDTCTTHPGCL A_0855_160 MTRSAMLMGRLTLVLCLLQLLLLTTQACFITNCPRGGKRDVDER-RSIKACMSCSFGQCVGPHICCGAGGCEMGTAEANRCSEEDDDPIPCEVLGDPCGPNNPGNNHGHCVAN--GICCVDDTCTTHPGCL A_0055_223 MTRSAMLMGRLTLVLCLLQLLLLTTQACFITNCPRGGKRDVDER-RSIKACMSCSFGQCVGPHICCGAGGCEMGTAEANRCSEEDDDPIPCQVLGDPCGPNNPGNNHGHCVAN--GICCVDDTCTTHPGCL A_0039_202 -----------------------TTQACFITNCPKGGKRDVDER-RSIKACMSCSFGQCVGPHICCGAGGCEMGTAEANRCSEEDDDPIPCQVLGDPCGPNNPGNNHGHCVAN--GICCVDDTCTTHPGCL A_0025_291 MTRSAMLMGRLTLVLCLLQLLLLTTQAYFIINYPKGGKRDVDER-FPTKLCMFCSFGQCVGPHICCGAGGCEMGTAEANRCSEEDDDPIPCQVLGDPCGPYDPGNIYGQCVAN--GICCVDDTCTTHPGCL A_0239_104 MTRSAMLMGRLTLVLCLLQLLLLTTQACFITNCPKGGKRDVDER-RSIKACLSCSFGQCVGPHICCGAGGCEMGTAEANRCSEEDDDPIPCQVLGDPCGPYNPGNNHGHCVAN--GICCVDDTCTTHPGCL A_0031_418 MTRSAMLMGRLTLVLCLLQLLLLTTQACFITNCPKGGKRDVDER-RSIKACLSCSFGQCVGPHICCGAGGCEMGTAEANRCSEEDDDPIPCQVLGDPCGPYNPGNNHGHCVAN--GICCVDDTCTTHPGCL A_0885_163 MTRSAMLMGRLTLVLCLLQLLLLTAQACFIRNCPRGGKRDVDER-RSIKACMSCSFGQCVGPHICCGAGGCEMGTAEANRCSEEDDDPIPCQVLGDPCGPYNPGNNHGHCVAN--GICCVDDTCTTHPGCL A_0239_105 MTRSAMLMGRLTLVLCLLQLLLLTTQACFITNCPKGGKRDVDER-RSIKACLSCSFGQCVGPHICCGAGGCEMGTAEANRCSEEDDDPIPCQVLGDPCGPYN----HGHCVAN--GICCVDDTCTTHPGCL A_0031_419 MTRSAMLMGRLTLVLCLLQLLLLTTQACFITNCPKGGKRDVDER-RSIKACLSCSFGQCVGPHICCGAGGCEMGTAEANRCSEEDDDPIPCQVLGDPCGPYN----HGHCVAN--GICCVDDTCTTHPGCL A_0025_290 MTRSAMLMGRLTLVLCLLQLLLLTTQACFIRNCPKGGKRDVDER-RSIKACMSCSFGQCVGPHICCGAGGCEMGTAEANRCSEEDDDPIPCQVLGDPCGPYNPGNNHGHCVAN--GICCVDDTCTTHPGCL A_0039_201 MTRSAMLMGRLTLVLCLLQLLLLTTQACFIRNCPTGGKRDVDER-RSIKACMSCSFGQCVGPHICCGAGGCEMGTAEANRCSEEDDDPIPCQVLGDHCILNNPGNIHGHCVAN--GICCVDDTCATHLECL V_1302_219 MTRSALQMGRLTLVLCLLLLLGLTTLACFVGNCPDDGKRDVDGR-QPTKPCKYCSFGQCVGPQICCGTRGCEMASAEANKCREEDDDPTPCQVFGYPCILNNPGNIHGHCVANNIGVCCVKDTCAVHSRCQ V_CG13_207 MTRSALQMGRLTLVLCLLLLLGLTTLACFVGNCPDGGKRDVDGR-QPTKPCKYCSFGQCVGPQICCGTRGCEMASAEANKCREEDDDPTPCQVFGYPCILNNPGNIHGHCVANNIGVCCVKDTCAVHSRCQ K_0010_102 MTRSAMQMGRLTLVLCLLQLLLLTTQACFIRNCPKGGKRDVDER-FPTKACMYCSFGQCVGPHICCGAGGCKIGTAEASMCSEEDDDPIPCQVLGDHCAMNNPGNIHGHCVAY--GICCVDDTCTTHSGCL ermineusAXL95401 MTRSAMQMGRLTLVLCLLLLLLLTTQACFIRNCPRGGKRDVDER-HPIKACMYCSFGQCVGPHICCGAGGCEMGTAEANRCSEEDGDPIPCQVIGNHCALNNPGNIHGHCVAN--GICCVDDTCTTHSGCL geographusP05486 MTRSAMQMGRLTLVLCLLLLLLLTTQACFIRNCPKGGKRDVDER-YLFKACMSCSFGQCVGPRICCGPRGCEMGTAEANRCIEEDEDPIPCQVVGQHCDLNNPGNIHGNCVAN--GICCVDDTCTIHTGCL gloriamarisGFNK01000009 MTRSARQMERLTLVLCLLLLLLLTTQACFIRNCPKGGKRDVDER-YHMKPCMNCTFGQCVGPSICCGAGGCQMGTAEANRCSEEDEDPIPCWVFGDYCNLNNPGNLHGSCVAN--GICCVDDTCASHWGCL radiatusP58990 ---------------------------------------------HPTKPCMYCSFGQCVGPHICCGPTGCEMGTAEANMCSEEDEDPIPCQVFGSDCALNNPDNIHGHCVAD--GICCVDDTCTTHLGCL andremeneziATF27388 MTRSAMLMGRLTLVVC----VLLTTQACFIRNCPKGGKRDVDDR-HPPKLCMSCSFGQCVGPHICCGDTGCEMGTPEANTCAREDEDPTPCLVIGSPCTLNNPGNTHGNCVSF--GICCVDDTCFFDLGCL praecellensATF27585 MTRSAMLMGRLTLVVC----LLLTTQACFIRNCPKGGKRDVDDR-HPPKLCMSCSFGQCVGPHICCGDTGCEMGTPEANTCAREDEDPTPCLVIGSPCTLNNPGNTHGNCVSF--GICCVDDTCVFDLGCL buxeusATJ04131 -----MQMGRLTLVLCLLLLLLLTTQGCFIRNCPKGGKRDVDER-QATKACMSCSFGQCVGPQICCGAGGCEMGTVEAKRCSEEDEDPIPCQVIGNHCALDNP----GHCAAY--GICCVDDTCTTHSGCL [Conopressin / Conophysin-2] [New Framework] [ /------------Signal-------------/C---------------------C--C-------C-----CC-----C---------C---------C------C-------C-----CC----C-----C-------------------/---Post--] A_0055_226 -------------------------------------------------------------------VGPSVCCGLGLGCLMGTPETEVCQKENESSVPCAISGRRCGMDNTGNCVADGICCVEDACSFNSLCRVDTDQEDSVSSRQELLTLIRRLLVNRQYD A_0885_169 MKCSVLQMSRLSWAMCLMLMMLLLL---GAAQGCFIRNCPRGGKRAVDAVQPTRQCMSCGPGGVGQCVGPSVCCGLGLGCLMGTPETEVCQKENESSVPCAISGRRCGMDNTGNCVADGICCVEDACSFNSLCRVDTDQEDSVSSRQELLTLIRRLLVNRQYD V_CG13_210 MKCSVLQMSRLSWAMCLMLLMLLLL---GTAQGCFIRNCPRGGKRAVDAVQPTRQCMSCGPGGVGQCVGPSVCCGLGLGCLMGTPETEVCQKENESSVPCAISGRRCGMDNTGNCVADGICCVEDACSFNSLCRVDTDQEDSVSSRQELLTLIRRLLVNRQYD V_1278_105 ----------------------------GTAQGGFIRNCPRGGKRAVDAVQPTRQCMSCGPGGVGQCVGPSVCCGLGLGCLMGTPETEVCQKENESSVPCAI------------------------------------------------------------- V_1258_167 MKCSVLQMSRLTWAMCLMLLMLLLL---GTAQGCFIRNCPRGGKRAVDAVQPTRQCMSCGPGGVGQCVGPSVCCGLGLGCLMGTPETEVCQKENESSVPCAISGRRCGMDNTGNCVADGICCVEDACSFNSLCRVDTDQEDSVSSRQELLTLIRRLLVNRQYD A_0031_059 MKCSVLQMSRLSWAMCLMLLMLLLL---GTAQGCFIRNCPRGGKRAVDAVQPTRQCMSCGPGGVGQCVGPSVCCGLGLGCLMGTQETEVCQKENESSVPCAISGRRCGMDNTGNCVADGICCVEDACSFNSLCRVDTDQEDSVSSRQELLTLIRRLLVNRQYD ermineusAXL95568 MKCSVLQMSRLSWAMCLMLLMLLLL---GTVQGCFIRNCPRGGKRAVDAVQPTRQCMSCGPDGVGQCVGPSVCCGLGLGCLMGTPETEVCQKENESSVPCAISGRRCGMDNTGNCVADGICCVEDACSFNSLCRVDTDQEDSVSARQELLTLIRRLLVNRQYD milesATJ04133 MKCSVLQMSRLSWAMCLMLLMVLLL---GTAHGCFIRNCPRGGKRAVDAVQPTRQCMPCGPDGMGQCVGPSVCCGLGLGCLMGTPETEVCQKENESAVPCAISGRHCGMDNTGNCVADGICCVEDACSFNSLCRVDTDQEDSVSARQELLTLIRRLLVNRQYD lividusATJ04130 MKCSVLQMSRLSWAMCLMLLMLLLL---GTAQGCFIRNCPRGGKRAVDALQPTRQCMSCGPEGVGQCVGPSVCCGLGLGCLMGTPETEVCQKENESSVPCAISGRRCGMDNTGNCVADGICCVEDACSFNSLCRVDTDQEDSVSARQELLTLIRRLLVNRQYD magusQFQ61128 MKCSVLQMSRLSWAMCLMLLMLLLL---GTAQGCFIRNCPRGGKRAVDAVQPTRQCMSCGPEGVGQCVGPSVCCGLGLGCLMGTPETEVCQKENESSVPCAISGRRCGMDNTGNCVADGICCVEDACSFNSLCRVDTDQEDSVSARQELLTLIRRLLVNRQYD CinguloterebraP0DN42 MKCSVLQMSRLSWTACVLLLPLLLLTLQGGVQGCFIRNCPRGGKRAVDSVQPTRQCMSCGPEGVGQCVGPSICCGLAIGCLMGTPEAEVCQKENESSAPCAVSGRHCGMDNTGNCVADGICCVEDACSFNSLCR----------------------------- [Conorfamide] [No Signal, No Framework] A_0875_143 MSGFGFLLPALLLLVTVEATKVEKETRGMR-VHSKKGRSWMRFGHPEMQSPLSSKRHRFRAL---------- A_0855_164 MSGFGFLLLALLLLVTVEATKVEKETRGMR-VHSKKGRSWMRFGHPEMQSPLSSKRHRFRAL---------- A_0885_164 MSGFGFLLLALLLLVTVEATKVEKETRGMR-VHSKKGRSWMRFGHPEMQSPLSSKRHRFRAL---------- A_0039_204 MSGFGFLLLALLLLVTVEATKVEKETRGMR-VHSKKGRSWMRFGHPEMQSPLSSKRHRFRAL---------- A_0055_221 MSGFGFLLLALLLLVTVEATKVEKETRGMR-VHSKKGRSWMRFGHPEMQSPLSSKRRRFRAL---------- V_1302_220 MSGFGFLLLALLLLVTVEATKVEKETRGMR-VHSKKGGDYIRFGHPEMQSLLSSKRHRFRAL---------- V_1278_107 MSGFGFLLLALLLLVTVEATKVEKETRGMR-VHSKKGGDYIRFGHPEMQSLLSSKRHRFRAL---------- A_0039_205 MSGFGFLLLALLLLLTVEATKVEKEKNGMRMNHMKRGGAFMRFGRRDMQTPLLSERLRTRALGFRQPSSQKQ A_0855_161 MSGFGFLLLALLLLLTVEATKVEKEKNGMRMNHMKRGGAFMRFGRRDMQTPLLSERLRTRALRFRQPSSQKQ A_1387_271 MSGFGFLLLALLLLLTVEATKVEKEKNGMRMNHMKRGGGFMRFGRRDMQTPLLSERLRTRALGFRQPSSQKQ A_0520_305 ----GFLLLALLLLVTVEATKVEKEKNGMRMNHIKGDGGYMRFGRRDMQTPLLSERLRTRALGFRQPSSRKQ A_0239_435 MSGFGFLLLALLLLVTVEATKVEKEKNGMRMNHIKGDGGYMRFGRRDMQTPLLSERLRTRALGFRQLSSQKQ victoriaeP0DOZ7 MSGRGFLLLALLLLVTVEATKVEKKHSGFLLAWSGPRNRFVRFGRRDMQSPLLSERLRL------------- [Insulin-related peptide1] [Framework XII] [ /--------Signal---------/-----C--------------C-----------C--------------------------------------------------------------------------C-CC---C--------C] A_0031_434 ------------------------------------------------------------------GGQRQLRKRTSMIDSDDMEADKGSLGGFLMNKRRALSYLQKETNPLVMAGYERRGVQKRHGDQGITCECCYNFCNFR------- A_0055_225 ------------------------AGLEHTCTLETRLQGAHPRGICGSKLPNIIHSVCQVMGRGYAGGQRQLRKRTSMIDSDDMEADKGSLGGFLMNKRRALSYLQKETNPLVMAGYERRGVQKRHGDQGITCECCYNFCNFRELVQYCN ermineusAXL95461 MATGLLSPLLVAMLGFLLHVHVARAGLEHTCTLETRLRGPHPRGICGSKLPNIIHTVCQVMGGGYAGGQRQLRKRTSMIDSDDMEANEGSLGGFLMSKRRALSYLQKETNPLVMAGYERRGIQKRHGDQGITCECCYNFCSFRELVQYCH imperialisAJD85819 MATSLLSPLLVAMLGFLLHVHVARAGLEHTCTLETRMQGAHPQGICGSKLPDIVHTVCQVMGRGYAGGQRQLRKRTSMIDSDDMEAEGGSRGGFLMSKRRALSYLQKETNPLVMAGYERRGIQKRHGEQGITCECCYNHCSFRELVQYCN [Insulin-related peptide2] [Framework XII] [ /----------Signal-----------/-----C--------------C-----------C------------------------------------------------------------C-CC---C--------C] V_1258_168 -----------------------------------------------------LARIVSVLCTPRGYVSNWFTKRSAPNNPAETFVDQNLRGVLLNKREALSYLRHREPRAARGTFGSQGITCECCFN------------ V_1278_109 MALTWPSSPPVLLTLLLSLLALQLCAVYGSYEHTCTLATRSRGAHPSGICGRNLARIVSVLCTPRGYVSNWFTKRSAPNNPAETFVDQNLQG------------------------------------------------ A_0885_168 MALTWPSSPPVLLTLLLSLLALQLCAVYGSYEHTCTLATRSRGAHPSGICGRNLARIVSVLCTPRGYVSNWFTKRSAPNNPAETFVDQNLRGMLLNKREALSYLRHREPRAARGTFGSQGITCECCFNQCTYYELLQYCN ermineusAXL95395 MALTWPSSSPVLLTLLLSLLALQLCAVYGSYEHTCTLATRSRGAHPSGICGRNLARIVSVLCTPRGYVSNWFTKRSAPNNPAETFVDQNLRGVLLNKREALSYLRHREPRAARGTFGSQGITCECCFNQCTYYELLQYCN monileANC47992 MALTWPSSPPVLLTLLLSLLALQLCAVYGSYEHTCTLATRSRGAHPSGICGRNLARIVSVLCTPRGYVSNWFTKRSAPNNPAETFVDQNLRGVLLNKREALSYLRHREPRAARGTFGSQGITCECCFNQCTYYELLQYCN imperialisAJD85825 MALTWPSSPPVLLTLLLSLLALQLCAVYGSYEHTCTLATRSRGAHPSGICGRNLARIVSVLCTPRGYVSNWFTKRSAPNKPAETFVDQNLRGVLLNKREALSYLRPREPRATRGTFGSQGITCECCFNQCTYYELLQYCN [Insulin-related peptide3] [Framework XII] [ /----------Signal--------------/---C-----------C-----------C----------------------------------------------------------------------------------------------------------------C-CC---C--------C] A_0885_167 MGLLRAVCQRIAMREVTPALLALLCLLGQAAGQTFCGVDSRPHPKGICGHMLLRAHRTLCFLLSADYPNIFSRSIHKRSLKNIDDFPLQTYAEMDLQRGHSQDQPTGTSPNTETMRKLFVSLFPRVHTLLPDVGNSVLTQGGPGSKGPSGDHLQAKRAGDDLLPHVQKRGMVCDCCYNVCQPSTLAQYCP ermineusAXL95359 MGVLRAVCQRIAMREVTPALLALLCLLGQATGQTFCGVDSRPHPKGICGHMLLRAHRTLCFLLSADYPNIFSRSIHKRSLKNIDDFPLQTYAEMDLQRGHSQDQPAGTSPNTETMRKLFVSLFPRVQTLLPDVGNSVLTQGGPGSNGPNGDHLQAKRAGDDLLPHVQKRGMVCDCCYNVCQPSTLAQYCP bullatusAOF40155 MGLLRAVCQRIAMREVTPALLALLCLLGQATGQTFCGVDSRPHPKGICGHMLLRAHRTLCFLLSADYPNIFSRSIHKRSLKNIDDFPLQTYAEMDLQRGHSQDQPTGTSPNTETMRKLFVSLFPRVQTLLPDVGNSVLTQGGPGSKGPSGDHLQAKRAGDDLLPHVQKRGMVCDCCYNVCQPSTLAQYCP striatusAOF40154 MGLLRAVCQRIAMREVTPALLALLCLLGQATGQTFCGVDSRPHPKGICGHMLLRAHRTLCFLLSADYPNIFSRSIHKRSLKNIDDFPLQTYAEMDLQGGHSQDQPTGTSPNTETMRKLFVSLFPRVQTLLPDVGNSVLAQGGPGSKGPGGDHLQAKRAGDDLLPHVQKRGMVCDCCYNVCQPSTLAQYCP geographusAOF40153 MGLLRAVCQRIAMREVTPAMLARLCLLGQAAGQTFCGVDSRPHPKGICGHMLLRAHRTLCFLLSADYPNIFSRSIHKRSLKNTDDFPLQTYAEMDLQRGHSQDQPTGTSPNTETMRKLFVSLFPRVQTLLPDVGNSVLTQGGPGSKGPGGDQLQAKRAGEDLLPHVQKRGMVCDCCYNVCQPSTLAQYCP bandanusAOF40152 MGVLRAVCQRIAMREVTPALLALLCLLGQATGQTFCGVDSRPHPKGICGHMLLRAHRTLCFLLSADYPNIFSRSIHKRSLKNIDDFPLQAYAEMDLQSGHSQDQPTGTSPNTETMRKLFVSLFPRVQTILPDVGNSVLTQGGPGSKGPSGDHLQAKRAGDDLLPHVQKRGMVCDCCYNACQPSTLAQYCP virgoAOF40156 MGVLRAVCQRIAMREVTPALLALLCLLGQATGQTFCGVDSRPHPKGICGHMLLRAHRTLCFLLSADYPNIFNRSIHKRSLKNIDDFPLQAYAEMDLQRGHSQDQPTGTSPNTETMRKLFVSLFPRVQTLLPDVGNSVLTQGGPGSKG----HLQAKRAGDDLLPHVQKRGMVCDCCYNVCQPSTLAQYCP [Insulin-related peptide4] [Framework XII] [ /-----Signal--------/-----C------------C-----------C------------------------------------------C-CC---C--------C-] V_1302_217 ---------------LHWSHAGYTRVCNRVKHPQRRYRECAEELPDLLNDVCRSLGGRRK---RENVGQLKRRRRSASLLKTRATRDPNLYYGSVCECCVHRCTLREIKEIC-- A_0055_222 MARRLGFLVVALGLLLHWSHAGYTRVCNRVTHPQRRYRECAEELPDLLNDVCRSSGGQRK---RENVRQLKKRQRSASLLKTRATRDSDLYYGSVCECCVHRCTLREMKEIC-- V_1302_278 ---------------LHWSHAGYTRVCNRVKHPQRRYRECAEELPDLLNDVCRSLGGRRK---RENVGQLKRRRRSASLLKTRATRDPNLYYGSVCECCVHRCTLREIKEIC-- K_0010_054 MARRLGFLIAALGLLLHWSHAGYTGVCNRVTHLQRKYRDCAAKLPELVNDVCRLTRASGGQRKRENVGQLEKRRRSASLLKTLATRDSHLYYGSVCECCVHQCTLREIREFC-- A_0875_145 MARRLGFLIVALGLLLHWSHAGHEHYCNPSAPPQSPQGICGPALAELVSLACQ-GSGSRRWG-RE------------------------------------------------- A_0039_200 MARRLGFLIVALGLLLHWSHAGHEHYCNPTAPPQSRQGVCGPALAELVSLACQ-GSGSRRWG-RENVRQLKKRGSIASLLKTRAKRGIR-PRGIVCECCINRCKFAEVREYC-- A_0239_310 MARRLGFLIVALGLLLHWSHAGHEHYCNPRAPPQSPQGVCGPALAELVTLACQ-GRGSRRWG-RENVRQLKKRGSIASLLKPRAKRGIR-PRGIVCECCINRCRFAEVREYC-- A_0031_120 MARRLGFLIVALGLLLHWSHAGHEHYCNPRAPPQSPQGVCGPALAELVTLACQ-GRGSRRWG-RENVRQLKKRGSIASLLKPRAKRGIR-PRGIVCECCINRCRFAEVREYC-- A_0048_101 MARRLGFLIVALGLLLHWSHAGHEHYCNPRAPPQSPQGICGSALAELVRLACQ-GSGSRRWG-RENVRQLKKRGSIASLLKTRAKRGIQ-PRGIVCECCINRCSFAEVREYC-- V_1302_319 MARRLGFFIVALALLLHWSHAGYEHYCDPGAPPEPREGVCGPALAELVSVVCHVSRGSHRWG-RENVRQLKKRGSIASLLKTRAKR---------------------------- K_0010_392 MARRLGFLIVALGLLLHWSHAGYEHYCDPTAPPVPPQGTCGSNLAEMISAVCRVTRGSRRWG-RENVSRLKKRGSIASLLKTRAKRTVP-SSGVVCECCVNRCTFEEFREYC-- ermineusAXL95338 MARRLGFLIVALGLLLHWSHAGLDHYCDPMQPPEPPRGICGQELANTVEAICQSGRRSRRWG-RENVSQLKKR--VSMLLKTRAKRTIK-PRGIVCECCVHRCTVAEFREYCPI [Insulin-related peptide5] [Endogenous] [Also described as Superfamily Y2 in Lavergne et al., 2013] [Framework XII] [ /--------Signal--------/----C-----------C-----------C--------------------------------------------------------C-CC---C--------C------/P-----] K_0010_136 MTTLSYFLLVALGLLLYVCQSSFGQEHSCQPDDPIHPDGKCGPALSEYREKQCEEEEAE--QGGTNNPRKKRGRASPLWKRRGFLSMLKTRAKRNEAFRLQRAYTGIVCECCKNHCTDEEFTEYCPPLTESSS------- K_0010_137 MTTLSYFLLVALGLLLYVCQSSFGQEYSCQPDDPIHPDGKCGPALSEYREKQCEEEEAE--QGGTNNPRKKRGRASPLWKRRGFLSMLKTRAKRNEAFRLQRAYTGIVCECCKNHCTDEEFTEYCPPLTESSS------- ermineusAXL95708 MTTSSYFLLVALGLLLYVCQSSFGNEHTCDPYAAPHPQGKCGGDLVDYVLKMCD--------GRTYSPGKKRGRASPLWKRRGFLSMLKARAKRNEAFPLQRSGQKGIACECCQNHCTDVEINKYCAEPK---------- pulicariusAOF40162 MMTSSYFLLVALGLLLYVCQSSFGQEHTCEPGDPDHPEGKCGPELSEYREEQCEEEEAE--QGGTNHALKKRGRASPQRKH--FLSMLKTRAKRNEASPLQRAG-RGIVCECCKNHCTDEEFTEYCPPLTESSC------ araneosusAQM52451 MTTSSYFLLVALGLLLYVCQSSFGGEHVCEPNEPNHPNGKCGSPMADYLEEQCEEEEAA--QGGTNNARATIGRAFSLSKRRGFLSMLKRRGKRNEASPQQRAS-QGIVCECCKNHCTDEEFTEYCPYVTESG------- victoriaeA0A0F7YYV0 MTTSSYFLLVALGLLLYVCQSSFGGEHVCWLDDPNHPEGICGPQVSDIVEIRCEEKEAE--QGGANNARAYTGRTSSLMKRRGFLSLLKKRGKRDEGS-LQRSG-RGIVCECCKHHCTKEELTEYCH------------- textileAOF40157 MTTSSYFLLVALGLLLYVCQSSFGSEHVCSNSEPNHPQGKCGPQLSEHVETNCEEEEAE--QGGANNARANTGRASSLMKRRGFLSLLKKRGKRNEGSPLQRSG-RGIVCECCKNHCTEEEFTEYCH------------- gloriamarisGFNK01000025.1 MTTSSYFLLVALGLLLYLCQSSFGSEYSCSYNDPDHPEGKCGPQLSEHVEEKCEEEEAE--QGGTNNARSNTGRASSLMKRRGFLSLLKKRGKRNEGSPLQRTG-RGIVCECCKNVCTKEEFTEYCPPLTESSG------ amadisAKZ17800 MTTSSYFLLVALGLLLYVCQSSFGSEHYCSLGEPNHPYGKCGPELSEYREEKCEEEEAE--QGGVNNARAKTGRASSLMKRRGFLSMLKKRGKRNDGAPLQRSG-RGIVCECCKNHCTKEEFTEYCPPLTESSG------ marmoreusBAO02230 MMTSSYFLLVALGLLLYVCQSSFGAEHICGSNEPNHPNGICGSDMADYLEEQCEEDEAA--HGGTNDARATIGRASSLSKRRGFLSMLKRRGKRNEASPLQRAG-RGIVCECCKNHCTDEEFTEYCPHVTESG------- marmoreusA0A0B5A8Q6 MTTSSYFLLVALGLLLYVCQSSFGGEHVCGSNQPNHPNGKCGSKMADYLEEQCEEEEAA--HGGTNDARATTGRALSLSKRRGFLSMLKRRGKRNEASPLQRAG-RGIVCECCKNHCTDEEFTEYCPHVTESG------- bandanusAOF40151 MTTSSYFLLVALGLLLYVCQSSFGGEHVCGSNQPNHPNGKCGSTMADYLEEQCEEEEAA--QGGTNDARATTGRASSLSKRRGFLSMLKRRGKRNEASPLQRAG-RGIVCECCKNHCTDEEFTEYCPHVTESG------- buxeusAMB57283 MMTSSYFLLVALGLLLYVCQSSFGSEHTCAPEDPPHPQGKCGSELHEHYEEMCELEEYL--NGGTDDTRKKRGRASPLRKRRGFLAMLKARAKRKEAFPLQIAD-RGIVCECCKNYCNYEEITEYCPELTESSG------ frigidusARU12135 MMSSSYFLLVTLGLLLYVCQSSIGTERTCEPEDPPDPQGRCGPALSQYHERMCELEEIR--HGGTFDPQKKRGRASPLRKRRGFLSMLKARAKRNEAGSLQRAG-RGIVCECCQNYCSDEEFTEYCPPVTESSS------ quercinusA0A0B5ABE6 MTTSSYFLLVALGLLLYLCQSSFGTEHTCEPGASPHPQGKCRPELAEFHETMCEVEESL--QGGTDDARKKRGRASLLRKRRGFLSMLKARAKRNEASPLPRAG-RGIVCECCKNSCTYEEITEYCPPVTEGSG------ litteratusARS01446 MTTSSYFLLVALGLLLYMCQSSFGSEFDCEPDDPDHPLGKCGPELSAFREEMCELEESW--QGGTDDSRKKRARASSLRKRRGFLSMLKVRAKRDEASTLPRAG-RGIICECCKNYCEYEEITEYCPPVTESSG------ floridulusAJD85837 MTTSSYFLLVTLGLLLYVCRSSFGTEHTCESDASPHPQGVCGSPLAEAVEAACELEEYL--QGGTG---KKRGRASPLRKRRAFLSMLKARAKRNEASPLQRSG-RGIVCECCKNHCNIEELTEYCPPVTEGSG------ lividusATG85034 MTTLSYFLLVALGLLLYVCRSSFGTEHTCEPYASPHPQGVCGQELTGLHELICEAEENF--HGGTG---KKRGRDSPLRKRRGFHSMLKARAKRNEASPLQRSV-QGISCECCKNHCTFEEITEYCPPVTEGSG------ eburneusAOF40160 MMTSSYFLLVALGLLLYVCQSSFGQEHSCNPDAAPHPQGTCGPELSERHEELCEMEEYL--HGGTDNTRKKRGWASPLRKRRGFLSMLKTRVKRNEAFPLQRAV-SGIACECCNNKCTDEEVTEYCPPLTESSG------ tessulatusAOF40164 MMTSSYFLLVALGLLLYVCQSSFGQEHSCDPDAAPHPEGTCGPELSERHEELCEKEESL--HGGTDNTRKKRGRASPLRKRRGFLSMLKTRVKRNEAFPLQRAV-SGMACECCNNKCTDEEVTEYCPPLTESSG------ virgoAOF40168 -MSSSYFLLVTLGLLLYVCQSSVGNEHTCEPDDPAHPQGKCGPELSEFHEEMCELEEYL--QGGTDDARKKRGRASPLRKR--FLSMLKARAKRNEAGSLQRAG-RGIVCECCKNNCNYEEITEYCPAVTESSS------ ebraeusASF90527 MTTSSYFLLVALGLLLYVCQSSFGQEHTCEPDAPAHPQGICGSELADYLEERCEEEEAE--HAGTYNTWKKRGRASPLRKR--FLSRLKKRAKRNEAFLLKRPT-QGLSCECCKNHCTDEEFIEYCPQVTES-------- tribbleiAOF40165 MSTSPCFLLVALGLLLYAWQACLGDEHTCDSSSTPHPQGKCGSELSEHREELCEIEESL--HGGTDDARKKRGRALPLKKRRRFL--LKARAKRNEALPLDRAR-RGIVCECCKNHCNYEEFTEYCPPVSEGSS------ geographusA0A0B5ADT3 MTTSSYFLLVALGLLLYVRQSFSTHEHTCQLDDPAHPQGKCGSDLVNYHEEKCEEEEAR--RGGTNDGGKKRRRASPLRKRRRFISMLKARAKR-------RGY-QGIACECCQHYCTDQEFINYCPPVTESSSSSSSAV virgoA0A0B5ADV0 MATSSCFLLVTLGLLLHV-QQAFLHEHTCSPSEPAAPGGICGSNLAELHSFLCEKELED--YSGS--ALKKRGRPSRRMKRRDFLSALKTRVKRKEGRSVKRSPTSGMSCECCKNSCDAEEILEYCPPLPSS-------- planorbisAOF40161 MTSPSYFLWVALGLLLYVYQAS-PQEYVCDSSSSPHQNGVCGAELTRVYEEMCETEASK--N--TRSAQRKRRQVFPLKKQ---LSLLKAKIKRDE----DKSS-EGMSCECCKHHCDYEEITEYCPELQE--------- magusQFQ61131 MTTSSYFLLVALGLLLYVYVCQSGQDYSCQLDDPADPRGKCGSDLPDYLEKKCEEEKARQGVSGTNDPGKKRGRASPLLKRRRFLSMMKARAKRNE--PFKRRGYKGIACECCQHYCTDPEFTKYCPPLPKSSS------ [Prohormone-4a] [Framework IX] [ /--------------------------------------------------------------------------Pro-------------------------------------------------------------------/------------------------------------------------------------------------------------------------------C-------------C------C-----C----------C-------------------------------------------------------------------------/-------------------------------] K_0010_422 MNSYNPMNPVTNVAHPMNSYY-PMNPVTNVAHP------------MNSYNPMNPVTNLAHPMNP-------------------YSPMNPINSLYNPMNVPYPFHPPMQVASYFLAPPLGTSYLLPSNGYG--HPVPMQAASKLLQPSLVAASPLNLHI--PYSYQAGMYSPYYLPPYHPSAALQTLYPPYGYAAGVPGAMASNQFGGAAWNPYSAMGYGAYPLWPSQFAHMWPLHPYYQTVVPAQEGMCSYDRPFQCWGSSTCITIDAVCDKTFDCNNHADEDPRICIAGRRPDYGTLVSYLALPDQQWMLQKLFNNVDPYTTAYALKLATSLGDLRWSLALTNENINNTKAVLEAVKNDDKEPLVALGMQASAWESVKFLMNSLLSTDFFSD K_0010_423 MNSYNPMNPVTNVAHPMNSYY-PMNPVTNVAHP------------MNSYNPMNPVTNLAHPMNP-------------------YSPMNPINSLYNPMNVPYPFHPPMQVASYFLAPPLGTSYLLPSNGYG--HPVPMQAASKLLQPSLVAASPLNLHI--PYSYQAGMYSPYYLPPYHPSAALQTLYPPYGYAAGVPGAMASNQFGGAAWNPYSAMGYGAYPLWPSQFAHMWPLHPYYQTVVPAQ--------------------------------------------GRRPDYGTLVSYLALPDQQWMLQKLFNNVDPYTTAYALKLATSLGDLRWSLALTNENINNTKAVLEAVKNDDKEPLVALGMQASAWESVKFLMNSLLSTDFFSD V_CG13_205 --------------MPFNSFHPPMHPLSYLHPPMGYPFVYPAMNTMNPHNLMNPMYNPAHPMHPMNLYNPMNPVTYPIHPTNLYNPMNPING----MSFPYPFHPPMRVASYFLTPPLGTSYLLPSNGYGHFHPVPTQAASKLLQPSLVTAAPLSLHMHFPYSHQAGVYSPYYLPPYHPAAALQTVYPPYGYAAGVPGAMGWNQFGGAAWNPYSAMGYGAYPMWPSQFAHMWPLHPYYQTVVPAQEGMCSYDRPFKCWGSSTCITIEAICDKTFDCNNHADEDPRICIAGRRPSYTTLVSYLALPDQKWMLEKLFNNVDPYMAAQALKLATSLGDLRWSLALTDENIKNTKTVLEAVKNDDKEPLVSLGMQASAWEAVKFLMNNLLSTDFFLD V_1278_106 --------------MPFNSFHPPMHPLSYLHPPMGYPFVYPAMNTMHPHNLMNPMYNPAHPMHPMNLYNPMNPVTYPIHPTNLYNPMNPING----MSFPYPFHPPMRVASYFLTPPLGTSYLLPSNGYGHFHPVPTQAASKLLQPSLVTAAPLSLHMHFPYSRQAGVYSPYYLPPYHPAAALQTVYPPYGYAAGVPGAMGWNQFGGAAWNPYSAMGYGAYPMWPSQFAHMWPLHPYYQTVVPAQEGMCSYDRPFKCWGSSTCITIEAVCDKTFDCNNHADEDPRICIAGRRPSYTTLVSYLALPDQKWMLEKLFNNVDPYMAAQALKLATSLGDLRWSLALTDENIKNTKTVLEAVKNDDKEPLVSLGMQASAWEAVKFLMNSLLSTDFFLD V_1302_218 --------------MPFNSFHPPMHPLSYLHPPMGYPFVYPAMNTMNPHNLVNPMYNPAHPMHPMNLYNPMNPVTYPIHPTNLYNPMNPING----MSFPYPFHPPMRVASYFLTPPLGTSYLLPSNGYGHFHPVPTQAASKLLQPSLVTAAPLSLHMHFPYSHQAGVYSPYYLPPYHPAAALQTVYPPYGYAAGVPGAMGWNQFGGAAWNPYSAMGYGAYPMWPSQFAHMWPLHPYYQTVVPAEEGMCSYDRPFKCWGSSTCITIEAICDKTFDCNNHADEDPRICIAGRRPSYTTLVSYLALPDQKWMLEKLFNNVDPYMAAQALKLATSLGDLRWSLALTDENIKNTKTVLEAVKNDDKEPLEALGMQASAWEAVKFLMNNLLSTDFFLD V_1258_166 --------------MPFNSFHPPMHPLSYLHPPMGYPFVYPAMNTMNPHNLVNPMYNPAHPMHPMNLYNPMNPVTYPIHPTNLYNPMNPING----MSFPYPFHPPMRVASYFLTPPLGTSYLLPSNGYGHFHPVPTQAASKLLQPSLVTAAPLSLHMHFPYSHQAGVYSPYYLPPYHPAAALQTVYPPYGYAAGVPGAMGWNQFGGAAWNPYSAMGYGAYPMWPSQFAHMWPLHPYYQTVVPAEEGMCSYDRPFKCWGSSTCITIEAICDKTFDCNNHADEDPRICIAGRRPSYTTLVSYLALPDQKWMLEKLFNNVDPYMAAQALKLATSLGDLRWSLALTDENIKNTKTVLEAVKNDDKEPLEALGMQASAWEAVKFLMNNLLSTDFFLD A_0055_220 MNSFYPYSAAV---MPFNSFHPPMHPLSYLHPPMGYPFVYPAMNTMNPHNLMNPMYNPAHPMHPM----------------NFYNPMNPING----MNFPYPFHPPMRVASYFLTPPLGTSYLLPSNGYGHFHPVPTQAASKLLQPSLVTAAPLSLHTHFPYSHQAGVYSPYFLPPYHPAAALQTVYPPYGYAAGVPGAMGWNQFGGAAWNPYSTMGYGANPMWPSQFAHMWPLHPYYQTVVPAQEGMCSYDRPFKCWGSSTCITIEAVCDKTFDCNNHADEDPRICIVGRRPSYDTLVSYLALPDQKWMLEKLFNNVDPYTAAQALKLATSLGDLRWSLALTDENINNTKTVLEAVKNDDKEPLEALGMQASAWEAVKFLMNNLLSTDFFLD A_0039_203 MNSFYPYSAAV---MPFNSFHPPMHPLSYLHPPMGYPFVYPAMNTMNPHNLMNPMYNPAHPMHPM----------------NFYNPMNPING----MNFPYPFHPPMRVASYFLTPPLGTSYLLPSNGYGHFHPVPTQAASKLLQPSLVTAAPLSLHTHFPYSHQAGVYSPYFLPPYHPAAALQTVYPPYGYAAGVPGAMGWNQFGGAAWNPYSTMGYGANPMWPSQFAHMWPLHPYYQTVVPAQEGMCSYDRPFKCWGSSTCITIEAVCDKTFDCNNHADEDPRICIVGRRPSYDTLVSYLALPDQKWMLEKLFNNVDPYTAAQALKLATSLGDLRWSLALTDENINNTKTVLEAVKNDDKEPLEALGMQASAWEAVKFLMNNLLSTDFFLD A_0855_158 MNSFYPYSAAV---MPFNSFHPPMHPLSYLHPPMGNPFVYPAMNTMNPHNLMNPMYNPAHPMHPM----------------NFYNPMNPING----MNFPYPFHPPMRVASYFLTPPLGTSYLLPSNGYGHFHPVPTQAASKLLQPSLVTAAPLSLHTHFPYSHQAGVYSPYFLPPYHPAAALQTVYPPYGYAAGVPGAMGWNQFGGAAWNPYSTMGYGANPMWPSQFAHMWPLHPYYQTVVPAQEGMCSYDRPFKCWGSSTCITIEAVCDKTFDCNNHADEDPRICIVGRRPSYDTLVSYLALPDQKWMLEKLFNNVDPYTAAQALKLATSLGDLRWSLALTDENINNTKTVLEAVKNDDKEPLEALGMQGSAWEAVKFLMNNLLSTDFFLD A_0875_144 MNSFYPYSAAV---MPFNSFHPPMHPLSYLHPPIGYPFVYPAMNTMNPHNLMNPMYNPAHPMHPM----------------NFYNPMNPING----MNFPYPFHPPMRVASYFLTPPLGTSYLLPSNGYGHFHPVPMQAASKLLQPSLVTAAPLSLHTHFPYSHQAGVYSPYFLPPYHPAAALQTVYPPYGYAAGVPGAMGWNQFGGAAWNPYSTMGYGANPMWPSQFAHMWPLHPYYQTVVPAQEGMCSYDRPFKCWGSSTCITIEAVCDKTFDCNNHADEDPRICIVGRRPSYDTLVSYLALPDQKWMLEKLFNNVDPYTAAQALKLATSLGDLRWSLALTDENINNTKTVLEAVKNDDKEPLEALGMQGSAWEAVKFLMNNLLSTDFFLD A_0885_170 -NSFYPYSAAV---MPFNSFHPPMHPLSYLHPPMGYPFVYPAMNTMNPHNLMNPMYNPAHPMHPM----------------NFYNPMNPING----MKFPYPFHPPMRVASYFLTPPLGTSYLLPSNGYGHFHPVPTQAASKLLQPSLVTAAPLSLHTHFPYSHQAGVFSPYFLPPYHPAAALQTVYPPYGYAAGVPGATGWNQFGGAAWNPYSTMGYGANPMWPSQFAHMWPLHPYYQTVVPAQEGMCSYDRPFKCWGSSTCITIEAVCDKTFDCNNHADEDPRICIVGRRPSYDTLVSYLALPDQKWMLEKLFNNVDPYTAAQALKLATSLGDLRWSLALTDENINNTKTVLEAVKNDDKEPLEALGMQASAWEAVKFLMNNLLSTDFFLD A_0520_207 MNSFYPYSAAV---MPFNSFHPPMHPLSYLHPPMGYPSVYPAMYTMNPHNLMNPMYNPAHPMHPM----------------NFYNPMNPING----MNFPYPFHPPMRVASYFLTPPLGTSYLLPSNGYGHFHPVPTRAASKLLQRSLVTAAPLSLHTHFPYSHQAGVYSPYFLPPYHPAAALQTVYPPYGYAAGVPGAMGWNQFGGAAWNPYSTMGYGANPMWPSQFAHMWPLHPYYQTVVPAQEGMCSYDRPFKCWGSSTCIPIAAVCDKTFDCNNHADEDPRICIVGRRPSYDTLVSYLALPDQKWMLEKLFNNVDPYTAAHALKLATSLGDLRWSLALTDENINNTKTVLEAVKNDDKKPLEALGMQASAWEAVKFLMNSLLSTDFFLD A_0048_228 MNSFYPYSAAV---MPFNSFHPPMHPLSYLHPPMGYPSVYPAMNTMNPHILMNPMYNPAHPMHPM----------------NFYNPMNPING----MNFPYPFHPPMRVASYFLTPPLGTSYLLPSNGYGHLHPVPTRAASKLLQRSLVTAAPLSLHTHFPYSHQAGVYSPYFLPPYHPAAALQTVYPPYGYAAGVPGAMGWNQFGGAAWNPYSTMGYGANPMWPSQFAHMWPLHPYYQTVVPAQEGMCSYDRPFKCWGSSTCITIEAVCDKTFDCNNHADEDPRICIVGRRPSYDTLVSYLALPDQKWMLEKLFNNVDPYTAAQALKLATSLGDLRWSLALTDENINNTKTVLEAVKNDDKEPLEALGMQTSAWEAVKFLMNNLLSTGFFLD A_0031_304 --------------MPFNSFHPPMHPLSYLHPPMGYPFVYPAMNTMNPHNLMNPMYNPAHPMHPM----------------NFYNPMNPING----MNFQYPFHPPMRVASYFLTPPLGTSYLLPSNGYGHFHPVPTQAASKLLQPSLVTAAPLSLHTHFPYSHQAGVYSPYFLPPYHPAAALQTVYPPYGYAAGVPGAMGWNQFGGAAWNPYSTMGYGANPMWPSQFAHMWPLHPYYQTVVPAQEGMCSFDRPFKCWGSSTCITIEAVCDKTFDCNNHADEDPRICIVGRRPSYTTLVSYLALPDQKWMLEKLFNNVDPYTAAQALKLATSLGDLRWSLALTDENVNNTKTVLEGVKNDDKEPLEALGMQASAWEAVKFLMNNLLSTDFFLD A_0239_316 -----------------------MHPLSYLHPPMGYPFVYPAMNTMNPHNLMNPMYNPAHPMHPM----------------NFYNPMNPING----MNFQYPFHPPMRVASYFLTPPLGTSYLLPSNGYGHFHPVPTQAASKLLQPSLVTAAPLSLHMHFPYSHQAGVYSPYFLPPYHPAAALQTVYPPYGYAAGVPGAMGWNQFGGAAWNPYSTMGYGANPMWPSQFAHMWPLHPYYQTAVPAQEGMCSFDRPFKCWGSSTCITIEAVCDKTFDCNNHADEDPRICIVGRRPSYTTLVSYLALPDQKWMLEKLFNNVDPYTAAQALKLATSLGDLRWSLALTDENVNNTKTVLGAVKNDDKEPLEALGMQASAWEAVKFLMNNLLSTDFFLD A_0025_248 ------------------------------------------MNTMNPHNLMNPMYNPAHPMHPM----------------NFHNPMNPIKG----MNFPYPFHPPMRVASYFLTPPLGTSYLLPFNGYGHFHPVPTQAASKLLQPSLVTAAPLSLHMHFPYSHQAGVYSPYFLPPYHPAAALQTVYPPYGYAAGVPGAMGWNQFGGAAWNPYSTMGYGANPMWPSQFAHMWPLHPYYQTVVPAQEGMCSYDRPFKCWGSSTCITIEAVCDKTFDCNNHADEDPRICIVGRRPSYDTLVSYLALPDQKWMLEKLFNNVDPYTAAQALKLATSLGDLRWSLALTDENINNTKTVLEAVKNDDKEPLEALGMQASAWEAVKFLMNNLLSTDFFLD praecellensATF27759 ---------------------------------------------------MNP-------------YSPMNPV------NSLYNPMKL----------TYPFRPPMQVASYFLTSPLGASYLLPS----------TKTASKLLQGSQVAASPLYLQTNFPYSYQSGMFSPFFLPPYQPSAALQALYPPYGFAAGVPGALAWNQFGGAAWNPYSAMGYGAYPQWPFQFAHMWPFNPYYQTVLPAQEGICSFDRPFKCWGSPTCIPIEAICDKIFDCSNHADEDPRLCIVGRRPGYDVLVSYLALPDQQWMLQKLFNNVDVYTTAYALRLATSLGDLRWSLALTDENINNTKTVMEAVKNDNEDPLVALGMKDSSWESIKFLFNRLLDTGFFLN andremeneziATF27504 ---------------------------------------------------MNP-------------YSPMNPV------NSLYNPMNL----------IYPFRP-----------PLGASYLLPS----------TKTASKLLQGSQVAASPLNLQTNFPYSYQSGMYSPFFLPPYQPSAARQALSPPYGFAAGVPGALAWNQFGGAAWNPYSAMGYGAYPQWPFQFAHMWPLNPYYQTVLPAQEGICSFDRPFKCWGSPTCIPIDAICDKIFDCSNHADEDPRLCIVGRRPGYDILVSYLALPDQQWMLQKLFNNVDVYTTAYALRLTTSLGDLRWSLALTDENINNTKTVMEAVKNDNEDPLVALGMKDSSWESIKFLFNRLLDTGFILN [Prohormone-4b] [Framework XXII] [ /-------------------C----------------------------C----C-------C-----C------C-----C----------C----------------------------------------------------------------------------------------------------------] A_0885_171 MSSALRLEITVL-VAAIMVTCSHGLKIDFSRLSLPSRNYLHTEKRS--SCQGNPCDPSTPFLCRDSPTCIRLVDICDGKWDCDGGFDEDPALCNAASRPPFDAMYKFLDDQKQWIIPKLFNGADPEMVAHELTLADNIESLQHHLGLTETNVKNIRQAFIAAVEGDERPLLGLGMPERSWPEVKYLLETLLESGFHV--- victoriaeA0A0F7YYX3 MSSPLRMDVTFL-LAAIAVTWVCGLKIGFPGFSTPPRSFIQHPKRT--LCPED-CDIASPFKCEESPTCLRLFQVCNGRWDCEHGSDEDNALCAAVLRPLECMIWEFLEGQRDWILPNLFNDANTDLVAHALHEAYSMGDLQSYLNLTDQNIENIRNSTRGAIVGDPRPLMALGMPDRAWPEVMYLLKELYNLGLDVWAE PomaceacanaliculataXP_025104707 MSFYVKLETFVL-FTAIVVTCLNGLKIDFSRLSLPSRAFFTPQKRN--VCEGNPCEASRPFLCRESPTCIRLKDICDGKDDCEDGFDESREVCFGASRPPMESIYQFLSDERKWMIPKLFNGADTEMVAHELTLATSIDELQRTLGLTPENVANLRKAFQSTIEGDERPLLAMGMPERSWPEVKFLFESLLKSGFRE--D biomphalariaglabrataXP_013069421 MIPRFRLEVAIVTLAAILITCAQGLKIDFSRLAARHTPSYLTQKRNEMTCTGNPCEKWKPFLCQSSSKCITIKSICDGFADCEDGFDEDPEVCNAASRPTVEDMTVFLNNERKWMVPQLFNGASIDLIAHVLTVASGMNDLRESLGLTDKNVELLDTAFVSSIEGDERPLLAMGMPERSWHEVQYVFQKLYDSGFKV--- [Thyrostimulin hormone alpha] [New Framework] [ /----------------Signal-----------------/Prepro/--------C-------------C---------C---C-------------------------CC-------------C--------------C-C--C---] A_0885_166 MASCSPDSVKTVRRRGHLVAYLLMTWLC-VTLCGHCPQCEASSDAGSISDSWKTPGCHLVGYTRIVMIPGCRTFQVTTNACRGFCLSFAYPTPEYLLLYHPEYIFTSRASCCNIIDTVDMPIQVHCGEESREVVFKSARSCGCSICRRK- ermineusAXL95509 MG--RRDSGRAVAQRYRGMARRVTVITCLMVVCACVGLCDATGRTSLRGHSWEIPGCHLVGHTRVVKIPDCVPFQMTTNACRGFCVSYAIPSPYRTLAYNPNHIITSRAECCDIIDTHDIPVQVRCVDGVKEIVFKSAKNCACSICRRE- victoriaeA0A0F7Z3J2 MG--RRDSGRAVAQRYRGVTRGVTVIACLMVVCACVGLCDATGQ---KRHSWEAPGCHLVGHTRVVRIPDCVPFQITTNACRGFCVSYAIPSPYQTLVYNPNHIITSRAACCDIIDTLDIPVQVTCVDGVREIVFKSARSCACSICRRE- AplysiaNP_001191641 ----------------------------------------------------EAPGCHLVGHTRTVSIPGCVSFEVTTNACRGFCVSYAIPSPSHTLAVNRNFVITSRAECCGIVDTHDVKVWVACRSGFQQKTFKSARSCQCSICRRSQ [Thyrostimulin hormone beta 5] [Framework VIII] [ /----------------Signal--------------/--------------C-----------------------C--------C---C-------------------C--------------C----------------C-C--C------C---/P] A_0055_224 ----------------------MVMPL-VLSLALTPPPLCHATLVNPRNTLQCHVRSYTFRATKPPIINQNGDLVTCQGDVRVKSCWGRCDSSEIGDFKMPFKISNHPVCTYTGRVSRTVSLSQCVG-YPDPTVQ------------------------ A_0885_165 MFYAMRKLMDKVTRLVRVRPVVMVMPL-VLSLALTPPPLCHATLVNPRNTLQCHVRSYTFRATKPPIINQNGDLVTCQGDVRVKSCWGRCDSSEIGDFKMPFKISNHPVCTYTGRVSRTVSLSQCVG-YPDPTVQVFDATGCACRFCNSDFTSCENLNG victoriaeA0A0F7YZI5 ----------------------MVMPL-VLSLALTPPPLCHATLVDPRTTLQCHVRSYTFRATKPPIVNENGDPVTCQGDVRVSSCWGRCDSSEIGDYKMPFKISNHPVCTYTGRVSRTVRLSQCAG-YPDPTVQVFDATGCACQFCNSETQLCEKLNG V_1278_108 M---MITLLKLATRLMRRLSHVLVFLA-VLCLALT---RASTSEVNPGTTLQCHVREYSYRTSKPPLLNQRGDLVTCEGIVRVNTCWGRCDSYEVGDFQMPFKVSHHPVCTYAGYRRRIVTLGNCRG-YPDPTIEVLDATACACRPCDSADTSCENLDG A_0885_162 M---MITLLKLATRLMRRLSHVLVFLA-VLCLALT---RASTSEVNPGTTLQCHVREYSYRTSKPPLLNQRGELVTCEGIVRVNTCWGRCDSYEVGDFQMPFKVSHHPVCTYAGYRRRIVTLGNCRG-YPDPTIEVLDATACACRPCDSADTSCENLDG ermineusAXL95452 M---MITLLKLATRLMRRLSHVLVFLA-VLCLALT---RASTSEVNPGTTLQCHVREYSYRTSKPPLLNQRGDLVTCEGIVRVNTCWGRCDSYEVGDFQMPFKVSHHPVCTYAGYRRRTVTLGNCRG-YPDPTIEVLDATACACRPCDSADTSCENLDG BiomphalariaXP_01308 M----SIVSRLTNLP-QSCPPPCVLATIVLLLGLL---MTPVHLIDPQTTLSCHLRRYQFRVTKPPIYVSDGSIVHCTGVVTVNSCWGRCDSSEVGDYVMPFKISHHPVCSYTGRDRKRVTLSDCEG-YPDPTVEVFDASGCECKLCDSDYTSCENLNG CrassostreaXP_011441 M--------------WKRCVWLVVLAAFSAVCA-----------VDLDSVTACLVREYNLFAQK-PHVTPTGDVLECSGFVKVNSCWGRCDSSEIADYKIPFKISNHPVCTYSRVQKRRVRLPNCHPEHPDPYYVVYDALACSCRYCNSKYTSCETLNG CapitellaELU07048 ----------------------------------------------------CHTRPYTYLASQ-PWVNKFGEILHCNGTITVNACLGSCESQEIPDYRMPYKLSRHPVCTFGEVRVRGFLLHNCHADHPDPFHITHEALSCRCKQCDPKTTRC----- ############################################################################################################################################################################################################################################################################################# Other venom proteins [Conodipine-1] [New Framework] [ /---------------Signal---------/Pro/-C------C------------C-------C-----C--C----------C-----------C---------C---------------------------------------------C---------------------------C-----C---] /----------------------------PA2-3 domain---------------------/ A_0875_179 --------MKPLVSVLWIIAALGVTWLVAVDSTSEQLCKKYSNGCST---P--WHLSCKEYFRPACDRHDSCYYCGKTFGISREKCDSAFKDDMQMLCKELAYPS-TCSGRRKRQVASGRATPIARSTLWKKAMHQKSFLNREV------PLPCFHWVGVYYAAVRAGGASSYSETVNEGACEALKPCLPDH A_0055_337 -----------------IIAALGVTWLVAVDSTSEQLCKKYSNGCST---P--WHLSCKEYFRPACDRHDSCYYCGKTFGISREKCDSAFKDDMQMLCEELAYPS-TCSARRKRQVASGRATPIARSTLWKKAMHQKSFLNRH------------------------------------------------- A_0039_230 --------MKPLVSVLWIIAALGVTWLVAVDSTSEQLCKKYSNGCST---P--WHLSCKEYFRPACDRHDSCYYCGKTFGISREKCDSAFKDDMQMLCEELAYPS-TCSARRKRQVASGRATPIARSTLWKKAMHQKSFLNRHA------PLPCFYWVGVYYAAVRARGASSYSETVNEGACEALKPCLPDH A_0239_247 --------MKPLVSVLWIIAALGVTWLVAVDSTSEQLCKKYSNGCST---P--WHLSCKEYFRPACDRHDSCYYCGKTFGISREKCDSAFKDDMQMLCEELAYPS-TCSARRKRQVASGRATPIARSTLWKKAMHQKSFLNRHA------PLPCFYWVGVYYAAVRARGASSYSETVNEGACEALKPCLPDH A_0031_347 --------MKPLVSVLWIIAALGVTWLVAVDSTSEQLCKKYSNGCST---P--WHLSCKEYFRPACDRHDSCYYCGKTFGISREKCDSAFKDDMQMLCEELAYPS-TCSARRKRQVASGRATPIARSTLWKKAMHQKSFLNRHA------PLPCFYWVGVYYAAVRARGASSYSETVNEGACEALKPCLPDH A_1387_244 --------MKLLVSVLWIMAALGVTWLVAVDSTSEQSCKRYSNGCTT---P--WSLPCQEYFRPACDRHDSCYYCGKTFGIGRKKCDSAFYDDMHTLCEELSFPG-NCPARRKRQVASGRATPIARSTLWKKAMHQKSFLNREARRFLRPSFTCFDWASKYYFAVILAGASSYSEIVNQGACEALKPCLPDH A_0855_203 --------MKLLVSVLWIIAALGVTWLVAVDSTSEQLCKKYSNGCST---P--WHLSCKEYFRPACDRHDSCYYCGKTFGISREKCDSAFKDDMQMLCEELAYPS-TCSARRKRQVASGRATPIARSTLWKKAMHQKSFLNRHA------PLPCFYWVGVYYAAVRARGASSYSGTVNEGACEALKPCLPNH A_0855_202 --------MKLLVSVLWIIAALGVTWLVAVDSTSEQSCKRYSNGCST---P--VPLPCQEYFRPACDRHDSCYYCGKTFGISRTKCDSAFYDDMSTLCEELSFPG-ICPARRKRQVASGRATPIARSTLWKKAMHQKSFLNREARIPLLPFTTCHSWASIYHQAVRLAGASSYSETVNQGACEALKPCLPNH ermineusAXL95375 --------MKLLAPVLWAMAALGVTWLVAVDSISEQSCKRYSDGCST---R--VPLPCKEYFRPACDKHDSCYRCGKTFEISREQCDEAFYVDMTTLCDERGFFG-MCPARRKRGVTSRRATSIAHARLWKKALHQRSFLNRKARLFFVPLTLCQDWAVKYQTAVKWAGASSYSETTYGSSCKGLRHCLPNH magusAXL95436 --------MKLLAPVLWAMAALGVTWLVAVDS-KE-SCTKHSNGCST---P--LRLPCQEYFRPACDIHDNCYHCGKTFGISRGECDEAFLKDMTALCEKLGRDSATCPATRKRGVTSRRATSIAHSRLWTKALVQKSFLNRKAGQSIQPPTSCQVWAQNYHWAVKLAGASRYSGTTDLEACQGLEHCLPNH [Conodipine-2] [New Framework] [ /-------Signal------/----------------C------C------------C------C-----C--C----------C-----------C---------C-------------------------------------------------C------------------------------C-----C-------] /-----------------------PA2-3 domain---------------------/ A_0855_247 --------MKVLESALWILAGLALPRIAAQDISTAELCKINSNGCSV---PLPGIPCEEHFRAACDRHDTCYLCGAHFSFTRDDCDNAFLTDMTALCAHGTDDEGFC-------------------------------------------------------------------------------------- A_0885_319 --------MKVLESALWILAALALPRIAAQDISTAELCKINSNGCSV---PFPGMPCEEHFRAACDRHDTCYLCGAHFSFTRDDCDNAFLTDMTALCAHGTDDEG---------------------------------------------------------------------------------------- A_0855_248 --------MKVLESALWILAGLALPRIAAQDISTAELCKINSNGCSVPSVPFYRIQCKEHFRAACDRHDTCYLCGAHFSFTRDDCDNAFLTDMTALCAHGTDDEGFC-------------------------------------------------------------------------------------- V_1302_262 --------MKMLESALWILAALALPWIAAQDSSTAELCKINSNGCSV---PVSFIPCQKHFLAACDRHDTCYFCGAHFGFTQDDCDNAFLTDMAALCADGTDDEGFCLEKRKRREASSMSITTPLRQLRLLEKLMPLNSLSDRDPRHLPQRAFTCTEWASHYFEGVQAFGSWHFNNTASATYCPQFEACMPVV A_0885_289 -------------------------------------------------------------------------------------------------AHGTDDEGFCPEKRKRREASSMSITTPLRQLRLLEKLMPPNSLSDRDPRQPHRR--TDTCTEWAQT---YFEGVQAFGSSHFSNTASATYCPQFEACMPVV---- A_0855_211 --------MKVLESALWILAALTLPWIVAQDSSTAELCKINGDGCSV---PLWLIPCQKHFRAACDRHDTCYLCGAHFGFTQDDCDNAFLTDMTALCAHGTDDEGFCLEKRNRREAFSMSITTPLRQLRLLEKLVPPNSLSDRDPRQPHRR--TATCTEWAQT---YFEGVQAFGSSHFSNTASATYCPQFEACMPVV---- A_0031_184 --------MKVLESALWILAALALPRIAAQDISTAELCKINSNGCSVPSVPFLRIQCKEHFRAACDRHDTCYLCGAHFSFTRDDCDNAFLTDMTALCADGTDDEGFCLEKRKRREASSMSITTPLRQLRLLEKLMPPNSLSDRDPRQPHRR--DATCTEWAQT---YFVGVQAFASSHFNNTASATYCAQFEACMPVV---- A_0855_212 --------MKVLESALWILAALTLPWIVAQDSSTAELCKINGDGCSV---PLWLIPCQKHFRAACDRHDTCYLCGAHFGFTQDDCDNAFLTDMTALCAHGTDDEGFCLEKRNRREAFSMSITTPLRQLRLLEKLVPPNSLSDRDPRQPHRR--AATCTEWAQT---YFEGVQAFASSHFNNTASATYCPQFEACMPVV---- A_0855_209 --------MKMLESALWILAALALPWIVAQDSSTAELCKINSNGCSV---PFSWIPCKEHFRTACDRHDTCYFCGAHFNFTQDDCDNAFLTDMTALCAHGTDDEGFCLEKRNRREAFSMSITTPLRQLRLLEKLVPPNSLSDRDPRQPHRR--AATCTEWAQT---YFEGVQAFASSHFNNTASATYCPQFEACMPVV---- A_0875_197 --------MKMLESALWILAALALPWIVAQDSSTAELCKINSNGCSV---PFSWIPCKEHFRTACDRHDTCYFCGAHFSFTQDDCDNAFLTDMIALCAHGTDDEGFCLEKRKRREASSMSITTPLRQLRLLEKLVPPNSLSDRDPRQPHRR--AGTCTEWAQT---YFEAVQDFGSWHFNNTASATYCPQFEACMPEV---- A_0039_261 -------------------------------------------------------------------------CGAHFSFTQDDCDNAFLTDMTALCAHGTDDEGFCLEKRKRREASSMSITTPLRQLRLLEKLVPPNSLSDRDPRQPHRR--AGTCTEWAQS---YFEAVQNFGSWHFNNMASATYCPQFEACMPEV---- A_0055_288 -------------------------------------------------------------------------CGAHFSFTQDDCDNAFLTDMTALCAHGTDDEGFCLEKRKRREASSMSITTPLRQLRLLEKLVPPNSLSDRDPRQPHRR--AGTCTEWAQS---YFEAVQNFGSWHFNNMASATYCPQFEACMPEV---- A_0055_287 --------------------------------------------------------------------------GAHFSFTRNDCDNAFLTDMTALCAHGTDDNGFCLEKRKRREASSMSITTPLRQLRLLEKLVPPNSLSDRDPRQPHRR--AGTCTEWAQS---YFEAVQNFGSWHFNNMASATYCPQFEACMPEV---- V_1258_222 --------MKVLESALWILAALALPWIAAQDISTAELCKINSNGCSV---PVSFIPCQKHFLAACDRHDTCYFCGAHFGFTQDDCDNAFLTDMAALCADGTDDEGFCLEKRKRREASSMSITTPLRQLRLLEKLMPLNSLSDRDPRQPHRR--IGTCTTWSEY---YFQGVQTMGSWYFYKTSNATHCPKFKACMPVV---- V_CG13_220 ----------------------------------------NSNGCSV---PVSFIPCQKHFLAACDRHDTCYFCGAHFGFTQDDCDNAFLTDMAVLCADGTDDEGFCLEKRKRREASSMSITTPLRQLRLLEKLMPLNSLSDRDPRQPHRR--IGTCTTWSEY---YFQGVQTMGSWYFYKTANATHCPKFKACMPVV---- V_1302_263 --------MKMLESALWILAALALPWIAAQDSSTAELCKINSNGCSV---PVSFIPCQKHFLAACDRHDTCYFCGAHFGFTQDDCDNAFLTDMAALCADGTDDEGFCLEKRKRREASSMSITTPLRQLRLLEKLMPLNSLSDRDPRQPHRR--IGTCTTWSEY---YFQGVQTMGSWYFYKTSNATHCPKFKACMPVV---- A_0025_361 ---------------------------------------------------------------------------------------------LALCAHGTDNEGFCLEKRKRREASSMSITTPLRQLRLLEKLVPPNSLSDCDPRQPHRR--AATCTEWAQA---YFEAVQNFGSWHFNNMANATYCPQFEACMPEV---- A_0048_213 --------MKVLESALWILAALALPRIAAQDISTAELCKINSNGCSV---PFPWIPCEEHFRAACDRHDTCYLCGAHFSFTRDDCDNAFLTDMTALCADGTDDEGFCLEKRKRREASSMSITTPLRQLRLLEKLMPPNSLSDRDSRQPHRR--TGTCTEWAQA---YFSGVQAYGSSHFNNTASATYCPQFEACMPVV---- A_0048_216 --------MKVLESALWILAALALPRIAAQDISTAELCKINSNGCSV---PFPWIPCEEHFRAACDRHDTCYLCGAHFSFTRDDCDNAFLTDMTALCAHGTDDEGFCPEKRKRREASSMSITTPLRQLRLLEKLMPPNSLSDRDSRQPHRR--TGTCTEWAQA---YFSGVQAYGSSHFNNTASATYCPQFEACMPVV---- A_0048_218 --------MKVLESALWILAALALPRIAAQDISTAELCKINSNGCSV---PFPWIPCEEHFRAACDRHDTCYLCGAHFSFTRDDCDNAFLTDMTALCADGTDDEGFCLEKRKRREASSMSITTPLRQLRLLEKLMPPNSLSDRDSRQPHRR--TGTCTEWAQS---YFEAVQNFGSWHFNNTASATCCPQFEACMPEV---- A_0048_214 --------MKVLESALWILAALALPRIAAQDISTAELCKINSNGCSV---PFPWIPCEEHFRAACDRHDTCYLCGAHFSFTRDDCDNAFLTDMTALCADGTDDEGFCLEKRKRREASSMSITTPLRQLRLLEKLMPPNSLSDRDPRQPHRL--ADTCTEWAQT---YFVGVQAFASSHFNNTASATYCPQFEACMPVV---- A_1387_297 --------MKMLESALWILAALALPWIVAQDSSTAELCKINSNGCSV---PFPWISCKEHFRTACDRHDTCYFCGAHFSFTQDDCDNAFLTDMIALCAHGTDDEGFCLEKRKRREASSMSITTPLRQLRLLEKLVPPNSLSDRDPRQP------------------------------------------------------ A_0520_239 --------MKMLESALWILASLALPWIVAQDSNTAELCKINSNGCSV---PFPWISCKEHFRTACDRHDTCYFCGAHFSFTQDDCDNAFLTDMIALCAHGTDDEGFCLEKRKRREASSMSITNPLRQLRLLEKLVPPNSLSDRDPRQPHRR--AGTCTEWAQTYFSYFEAVQDFGSWHFNNTASATYCPQFEACMPEV---- A_0031_185 --------MKMLESALWILAALALPWIVAQDSSTAELCKINSNGCSV---PFPSIPCKEHFRTACDRHDTCYFCGAHFGFTRDDCDNAFLTDMSALCAHGT-DEGFCLEKRKRREASSMSITTPLRQLRLLEKLVPPNSLSDRDPRQPHRF--AGTCTKWAES---YFEAVQVFGSWYFNNMASATYCPQFEACMPEV---- A_0520_240 --------MKVLESALWILAALALPRIAVQDISTAELCKINSNGCSV---PFPGIPCEEHFRAACDRHDTCYLCGAHFSFTRDDCDNAFLTDMTALCADGTDDEGFCLEKRKRREASSMSITTPLRQLRLLEKLMPPNSLSDRDPRQPHRR--AGTCTEWAQT---YFVGVQAFASSHFNNTASATYCPQFEACMPEV---- A_0048_215 ------------------------------------------------------------------------LCGAHFSFTQDDCDNAFLTDMTALCAHGTDDEGFCPEKRKRREASSMSITTPLRQLRLLEKLMPPNSLSDRDPRQPHRL--ADTCTEWAQT---YFVGVQAFASSHFNNTASATYCPQFEACMPVV---- A_0520_242 --------MKMLESALWILASLALPWIAAQDSSTAELCKINSNGCSV---PFPGIPCEEHFRAACDRHDTCYLCGAHFSFTRDDCDNAFLTDMTALCADGTDDEGFCLEKRKRREASSMSITTPLRQLRLLEKLMPPNSLSDRDPRQPHRR--AGTCTEWAQT---YFSGVQAYGSSHFNNTASATYCPQFEACMPEV---- A_0239_380 --------MKVLESALWILAALALPRIAVQDISTAELCKINSNGCSV---PLPGIPCEEHFRAACDRHDTCYLCGAHFSFTRNDCDNAFLTDMTALCAHGTDDNGFCLEKRKRREASSMSITTPLRQLRLLEKLMPPNSLSDRDPRQPHRR--AGTCTEWAQT---YFVGVQAFGSSHFSNTASATNCAQFEACMPVV---- A_0520_241 --------MKVLESALWILAALALPRIAVQDISTAELCEINSNGCSVPSIPFFRIQCQEHFRAACDRHDTCYLCGAHFSFTRDDCDNAFLTDMTALCADGTDDEGFCLEKRKRREASSMSITTPLRQLRLLEKLMPPNSLSDRDPRQPHRR--AGTCTEWAQT---YFSGVQAYGSSHFNNTASATYCPQFEACMPEV---- A_0520_243 --------MKVLESALWILAALALPRIAVQDISTAELCEINSNGCSVPSIPFFRIQCQEHFRAACDRHDTCYLCGAHFSFTRDDCDNAFLTDMTALCADGTDDEGFCLEKRKRREASSMSITTPLRQLRLLEKLMPPNSLSDRDPRQPHRR--AGTCTEWAQT---YFVGVQAFASSHFNNTASATYCPQFEACMPEV---- A_0239_379 --------MKVLESALWILAALALPRIAVQDISTAELCKINSNGCSVPSFVFLSIQCKEHFRAACDRHDTCYLCGAHFSFTRNDCDNAFLTDMTALCAHGTDDNGFCLEKRKRREASSMSITTPLRQLRLLEKLMPPNSLSDRDPRQPHRR--AGTCTEWAQT---YFSGVQTYGASHFNNTASATYCPQFKACMPVV---- A_0025_358 -----------------------------------------------------------------------------------DCDNAFLTDMTALCADGT-DEGFCLEKRKRREASSMSITTPLRQLRLLEKLMPPNSLSDCDPRQPHRR--AATCTEWAQA---YFEGVQAFASSHFNNTASATYCPQFEACMPVV---- A_0025_359 --------MKMLESALWILAALALPWIVAQDSSTAELCKINSNGCSV---PLRWIPCKEHFRTACDRHDTCYFCGAHFGFTQDDCDNAFLTDMTALCAQGTDDEGFCLEKRKRREASSMSITTPLRQLRLLEKLMPPNSLSDCDPRQPHRR--AATCTEWAQA---YFEGVQAFASSHFNNTASATYCPQFEACMPVV---- A_0048_217 ------------------------------------------------------------------------LCGAHFSFTQDDCDNAFLTDMTALCAHGTDDEGFCPEKRKRREASSMSITTPLRQLRLLEKLMPPNSLSDRDSRQPHRR--TGTCTEWAQA---YFSGVQAYGSSHFNNTASATYCPQFEACMPVV---- A_0025_360 --------MKMLESALWILAALALPWIVAQDSSTAELCKINSNGCSV---PLRWIPCKEHFRTACDRHDTCYFCGAHFGFTQDDCDNAFLTDMTALCAQGTDDEGFCLEKRKRREASSMSITTPLRQLRLLEKLMPPNSLSDCDPRQPHRR--AATCTEWAQA---YFSGVQAYGSSHFNNTASATYCPQFEACMPVV---- V_1302_262 --------MKMLESALWILAALALPWIAAQDSSTAELCKINSNGCSV---PVSFIPCQKHFLAACDRHDTCYFCGAHFGFTQDDCDNAFLTDMAALCADGTDDEGFCLEKRKRREASSMSITTPLRQLRLLEKLMPLNSLSDRDPRHLPQR--AFTCTEWASH---YFEGVQAFGSWHFNNTASATYCPQFEACMPVV---- V_1258_221 --------MKVLESALWILAALALPRIAAQDISTAELCKINSNGCSVPSIPFLRIQCKEHFRAACDRHDTCYLCGAHFSFTRDDCDNAFLTDMTALCAHGTDDEGFCLEKRKRREASSMSITTPLRQLRLLEKLMPLNSLSDRDPRHLPQR--AFTCTEWASH---YFEGVQAFGSWHFNNTASATYCPQFEACMPVV---- V_CG13_221 --------MKVLESALWILAALALPRIAAQDISTAELCKINSNGCSVPSIPFLRIQCKEHFRAACDRHDTCYLCGAHFSFTRDDCDNAFLTDMTALCAHGTDDEGFCLEKRKRREASSMSITTPLRQLRLLEKLMPPNSLSDRDPRHLPQR--AFTCTEWAQS---YFEGVQAFGSWHFNNTASATYCPQFEACMPVV---- A_0025_356 ---------------------------------------INSNGCSV---PLRWIPCKEHFRTACDRHDTCYFCGAHFGFTQDDCDNAFLTDMTALCAQGTDDEGFCLEKRKRREASSMSITTPLRQLRLLEKLMPPNSLSDYDPRQPQER--DFTCTGWAKK---YVQGVQAIGSWYFYDTANATYCPQFEACMPEV---- A_0855_213 --------MKVLESALWILAALTLPWIVAQDSSTAELCKINGDGCSV---PLWLIPCQKHFRAACDRHDTCYLCGAHFGFTQDDCDNAFLTDMTALCAHGTDDEGFCLEKRNRREAFSMSITTPLRQLRLLEKLVPPNSLSDRDPRQPQER--FFTCTGWAKK---YFQGVQAIGSWYFYGTANATYCPQFEACMPVV---- A_1387_298 ----------VLESALWILAALALPRIAAQDISTAELCEINSNGCSVPSVPFFRIQCKEHFRAACDRHDTCYLCGAHFSFTRDDCDNAFLTDMTALCADGTDDEGFCPEKRKRREASSMSITTPLRQLRLLEKLMPPNSLSDYDPRQPQER--VFTCTGWAKK---YFQGVQAIGWWYFYDTANATYCPQFE---------- A_1387_300 --------MKMLESALWILAALALPWIVAQDSSTAELCKINSNGCSV---PFPWISCKEHFRTACDRHDTCYFCGAHFSFTQDDCDNAFLTDMIALCAHGTDDEGFCLEKRKRREASSMSITTPLRQLRLLEKLMPPNSLSDYDPRQPQER--VFTCTGWAKK---YFQGVQAIGWWYFYDTANATYCPQFEACMPVV---- K_0010_305 --------MKVLESAWWILTALALPWIVAQDSSTAELCKINSNGCSV---PFSLIPCQKHFLTACDKHDTCYLCGAHFGFTQDDCDNAFLRDMTALCAEGTDDEGFCLEKRKRREASSMSITTPLRQLRLLEKLMPLNSLSDRDPHQPQKRF-FYNCTEWSEQ---YFDTVQIFGSWFFYDTADATHCPRFKACMPSTA--- K_0010_306 --------MKVLESAWWILTALALPWIVAQDSSTAELCKINSNGCSV---PFSLIPCQKHFLTACDKHDTCYLCGAHFGFTQDDCDNAFLRDMTALCAEGTDDEGFCLEKRKRREASSMSITPPLRHLRLLEKLMPLNSLSDRDPRQPQKR--FATCTGWANA---YFGAVQTFGSRYFYDTASATYCPLFNACMPLV---- geographusJAB84561 --------MKMLESALWILAALALPWIAAQDSSTAELCKINSNACSV---PFSWVPCQGHFLPACDRHDTCYHCGRHFGFTQKDCDNAFFTDMTALCAQGTDDEGYCLEKRKRREASSISITTQLRQLQVLEKLMPPNSLSVRDPRQLH-R--VATCTAWASV---YHWTVSKFGWWHFNYWPDTTYCPQFKACMPEV---- ermineusAXL95635 --------MKVLESALWILAALALPRIAALDSSTAELCRVNSNACSV---PFKWIPCQQHFLPACDRHDTCYHCGGHFSFKQGDCDDAFFRDMEALCAQGT-DEGFCPDKRKRRDASSTAITT--RQLRLLEKFMPPNFFSDRDPRQPHPR--AFTCNQWVSV---YFRTVQVFGWWHFNYRASAKECPPFEPCMPEVGSTA gloriamarisGFNK01000007 --------MKMLESALWILAALAMPWIAAQDSRTAELCKINSNGCSV---PVSSVPCQQHFLAACDRHDTCYLCGAHFSLTQKDCDDAFLAHMIALCADGTDDEGFCLEKRKRREASSMSITTPLRQLQLLEKLMPLNSLWDHDSRQPQQRFIYDNCTDWAST---YYNTVQTFGSFYFYNTANATYCPQFEPCMPEVSS-- monileANC47998 --------MKMLESALWILAALALPWIAAQGSSTAELCKINSNGCST---LTPWTPCREHFRPACDRHDTCYFCGDYFNFTQAACDEAFLNDMTALCAHGTDDEGYCLNKRKRREASRMSITTRLRHLQLRKKLTPPNSLSDRDSHQLHTR--SANCTEMALN---YYDAVRVFGALHYSSSANATICPPYGACMPEA---- magusQFQ61155 --------MKMLESALWILAALALPRIAAQNPSTAELCKINSNACSV---PFSWIPCQKHFLAACDRHDTCYHCGKHFGFKQDDCDDAFFRDMTALCAHGTDDEGSCPEKRKRREASSMSITTPLRQLRQLEKLVLPNSLSARDPRQLHSR--AATCTHWALI---YFKTVQLFGWWHFNYQVDATYCPQFQPCMPQV---- [Conodipine-3] [Framework VIII] [ /--------------Signal-----------/--C--------C--------------------C-----C--C----------C-----------C-----------------C----------------------------C-------C-] /----------------------------PA2-3 domain------------------------/ A_0885_192 MMQPPMSAPPL-V-VVVVAV--MMMMMAMPVKADQCDQHPTVNGCSV---PSFIKPQHQDTFTPACNRHDVCYGCGAKYGVTRWQCDNAFLRDMEEACRQVRGRR-TLTVQVEMDCENMANAFYAAVRLAGRSHYVEADTPNSDCRENVDKPCLP A_0039_210 MMQPPMSAPPL-V-VVVVAV--MMMMMAMPVKADQCDQHPTVNGCSV---PSFIKPQHQDTFTPACNRHDVCYGCGAKYGVTRWQCDNAFLRDMEEACRQVRGRR-TLTVQVEMDCENMANAFYAAVRFAGRSHYVEADTPNSDCREKVDKPCLP A_0055_283 MMQPPMSAPPL-V-VVVVAV--MMMMMAMPVKADQCDQHPTVNGCSV---PSFIKPQHQDTFTPACNRHDVCYGCGAKYGVTRWQCDNAFLRDMEEACRQVRGRR-TLTVQVEMDCENMANAFYAAVRFAGRSHYVEADTPNSDCREKVDKPCLP V_CG13_277 M---------------------MMMMMAMPVKADQCDQHPTVNGCSV---PSFIKPQHQDTFTPACNRHDVCYGCGAKYGVTRLQCDNAFLRDMEEACRQVRGRR-TLTVQVEMDCENMANAFYTAVRFAGRSHYVEADTPNSACREEVDKPCLP A_0239_313 MMQPPMSAPPL-V-VVVVAV--MMMMMAMPVKADQCDQHPTVDGCSV---PSFIKPQHQDTFTPACNRHDVCYGCG------------------------------------------------------------------------------- A_1387_346 --------------------------------------------------PSFIKPQHQDTFTPACNRHDVCYGCGAKYGVTRWQCDNAFLRDMEEACRQVRGRR-TLTVQVEMDCENMANAF-------------------------------- A_0031_275 MMQPPMSAPPL-V-VVVVAV--MMMMMAMPVKADQCDQHPTVDGCSV---PSFIKPQHQDTFTPACNRHDVCYGCGAKYGVTRWQCDNAFLRDMEEACRQVRGRR-TLTVQVEMDCENMANAFYAAVRLAGRSHYVEADTPNSDCREEVDKPCLP K_0010_044 MMQPPMSAPPLRVMVVVVAVMMMMMMMAMPVKADQCDRHPTVNGCSV---PSFLQLQHQDTFTPACNRHDVCYGCGAKYGVTRGQCDDAFLRDMKEACRQKRGRR-TLTVEVEMECENMATAFYRAVWAAGFLNYVRAGTPNSDCRKDLDKPCLP PomaceaXP_025076316 MM----SLKLLLALALVAVV-TGSQEFEVGARRRREVCAEHSNGCSI---PGDLPFFYKNTFTPACDRHDMCYNCGSLLGYTKDQCDQYFLNNMLKICASVRRRRDTLSRKYRSTCTLTATVYYEGVHLAGASHFRVPGHTDPYCTTDLVRTCVP [Conohyaluronidase] [New Framework] [ /-------Signal------/-------------------------C--------------------C--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------C------------------------C----C-----C--------------------C-----------C-C-------CC-------C--------------------------------------------] A_0025_021 ------------------------------SPLSSSSAYQGSSGDDCDEGLPPPDRPFNVVWNHPDTCKRNRIPLHLDHYGFIFNKNRLFLGEEIQTLYNTGLWPNISETGEFFNGGLPQLFTHHDY-SETRKILGLHRTENFTGLAVLDFEEWRAIYDTNFGIMRKYQDESIKLAKQRYPGYNKKELTMVAEQEWQQAARKIMSNKLAIGQALMPGGHWGYYGYPRTWGSKADTQLRNNRIEWLWRQSTGLYPSIYIK--DPNMTESAIAKFVSGNVEEAVRVQDEFSPPNTPIYPYAMLQSGDDIFFQEDHLKISLGLPAKMGTSGVILCASSNRYKNATR--QCSRLQVHIQ---------------------------------------------------------------------------------------------------------------------------- ermineusAXL95480 MRVVVVVTGLVVVVVATALSLPDYDVKSASSPLSSSSVYQGSSGDDCDEGLPPPDRPFNVVWNHPDTCKRNRIPLHLDHYGFIFNKNRLFLGEEIQTLYNTGLWPNISETGEFFNGGLPQLFTHHDY-SETRKILGLHRTENFTGLAVLDFEEWRAIYDTNFGIMRKYQDESIKLAKQRYPGYNKKELTMVAEQEWQQAARKIMSNKLAIGQALMPGGHWGYYGYPRTWGSKADTQLRNNRIDWLWRQSTGLYPSIYIK--DPNMTESAIAKFVSGNVEEAVRVQDEFSPPNTPIYPYAMLQSGDDIFFQEDHLKISLGLPAKMGTSGVILWASSNRYKNATR--QCSRLQVHIQTVLGPFIKNLTQVMADCSTTLCGGHGRCVHNSHDVLLSETESQRLSGLCTPRHSRFRDYHCRCYSAWEGACCQTVRPSRCHKQQQGNVHEGGDLQERQVVNGTGTHTTPGADVVNPLIGRTFLE purpurascensC0HKM3 MRVVVVVTGLVVVVVATALSLPDHDVKSASSPLSSSSVYQGSSGDDCDEGLPPPDRPFYVVWNHPDTCKRNRIPLHLDHYGFIFNKNRLFLGEEIQTLYNTGLWPNISETGEFFNGGLPQLFTHHDY-SETVEILGRYRTENFTGLGILDFEEWRAIYDTNFGIMRKYQDESIKLAKQRYPSYNKKELTMVAEQEWDQAAREIMSTKLAIGQALMPGGHWGYYGYPRTWGSKRNTQLRNNRIDWLWRQSTGLYPSIYIK--DPNMTESAIAEFVSGNVEEAVRVQDEFSPPNTPIYPYAMLQSGDHIFFQVDHLKISLGLPAKMGTSGVILWASSNRYKNATR--QCSRMRVHIDNVLGPYVENLTQVMADCSTTLCGGHGRCVHNSHDVLLGETDSQRLSGLCTPRHSRFRDYHCRCYSDWEGACCQTVRPSRCHKQQQGNVHEGGDLQEGHVVN-----------VVNPLIG----- magusQFQ61157 MRVLVVVTGLVVVVVATALSLPDHDVKSATSSLSSSSVYQGSSGDDCDEGLPPPDQPFRVVWNHPDNCERIKLHLPLDEYGIIFNKLRVFLGEEIQTLYDTGPWPYISETGKFINGGLPQSFNHPDNDGETQRILKKHKPENFTGLGVLDFETWRAIYSTNFGPMAIYQNESVKLVKEKHPDYDQKKLTKVAEKEWQQAAKDIMSTKLKIAQEVMPRGHWGYYLYPRTWDNKRDTKFRNDKINWLWRQSTGLYPSIYIY--DFSKTESAITKFVSDTVGEAVRVQKEFSPPNTPIYPYVMFQTMDNIFHYEDHLKISLGLSAKMGAAGVVLWGTSKHYKESTRQWQCQQLQEHIRTVLGPLVKNVTQMMTDCSRAICEGHGRCVHNSHDVILGETESQRLSDLCSTRQSRFRDYHCRCYSAWEGACCQTLRPSRCQKREQRNVHGGGDLID---------------------------- adamsoniiI0CME8 MRAVVVVTGLVVVVVTTTLSLQDHDVKSASSPL-SSSVDQGSSGDDCDEGLPPPDQPFRVVWNHPDNCEKINLHLPLDEYGIIFNKRRVFLGEEIQTLYDTGPWPYINKTGCFINGGLPQLFNQPDN-SETCKILGKNRIEDFTGLGVLDFETWRAIYSTNFGTMENYQIESVNLVRKRHPDYSEKELKMVAEQEWQEAARKIMTDKLAAGQSLMPRGYWGYYLYPRTWDSKPDTKFRNNKIDWLWRQSTGLYPSIYIYYDVVSKTDSVITKFVSDTVGEAVRVQNDFSPPNTPIYPYVMFQTMDNVFHKEDHMKISLGLSAKMGAAGVILWGSSQNYKDFTT--QCSRLQ-------------------------------------------------------------------------------------------------------------------------------- [Conoporin] [No Signal, No Framework] V_CG13_312 ------------------------------------------------------------------------------------------------------------------------------------------------FVLMWSAPYSFDFHKNWMGLGMTREGSVNVASGNTWFDQMYYGSNNGDLTFQRGEFYYYTDPVIYRNDKFEAVGVMTNIHRAQIKVIIRPTRNNWKDLAAPIRALLEQQQKRAL------QRGN---- A_0039_307 ----------------------------------------------------------------------------------------------------------------------------------------EMHGAGRRFVLMWSAPYSFDFHSNWMGLGMTREGSVNVASGNTWFDQMYYGSNNGDLTFQRGEFYYYTDPVIYRNDKFEAVGLMTNIHRAQIKVIIRPTRNNWKDLAAPMRVLLEQQQKRGL------QRGN---- A_0055_277 ----------------------------------------------------------------------------------------------------------------------------------------EMHGAGRRFVLMWSAPYSFDFHSNWMGLGMTREGSVNVASGNTWFDQMYYGSNNGDLTFQRGEFYYYTDPVIYRNDKFEAVGLMTNIHRAQIKVIIRPTRNNWKDLAAPMRVLLEQQQKRGL------QRGN---- A_0885_229 MKNAQLYKKGVPFPALKTMVTVFLLLMGNTSPVQPVVLSSSISLSTVAGIASQVISAGTSLAGVTLQGLAASGYRVTCAIQVENWTRYPLLYPTVRVLGSAAVTSAPTAILPGKKEAFAVRKPSGTATGAAGTVSWEIHGAGRRFVLMWSAPYSFDFHSNWMGLGMTREGSVNVASGNTWFDQMYYGSNNGDLTFQRGEFYYYTDPVIYRNDKFEAVGLMTNIHRAQIKVIIRPTRNNWKDLAAPMRVLLEQQQKRGL------QRGN---- A_0239_423 MKNAQLYKKGVPFPALKTMVTVFLLLMGNTSPVQPVVLSSSISLSTVAGIASQVISAGTSLAGVTLQGLAASGYRVTCAIQVENWTRYALMYPTVDTFGNPGVTTAPTAILPTKKEAFATRKPQSTATGVSGTVSWELQGVGRRFVLMWAAPFNFNHFSNWMGVGMTREGLVDVAPGNSWFDQMYYDSNSDDLTFERGEFYDDLKPVIYRNDKFEVEGVMTNIHKAQIKVVIRPTIDNWRDMALPIQALLVQQEKEVCDMTTEHIYFFHGDT A_0239_422 --------MGVPFPALKTMVTVFLLLMGNTSPVQP-AIVSGTISATVASIASSVITAGTSLAGSTLDTMADPNYSVTCAIQVENWTRYALMYPTVDTFGNPGVTTAPTAILPTKKEAFATRKPQSTATGVSGTVSWELQGVGRRFVLMWAAPFNFNHFSNWMGVGMTREGLVDVAPGNSWFDQMYYDSNSDDLTFERGEFYDDLKPVIYRNDKFEVEGVMTNIHKAQIKVVIRPTIDNWRDMALPIQALLVQQEKEVCDMTTEHIYFFHGDT A_0031_413 ------------------------------SPVQPVVLSSSISLSTVAGIASQVISAGTSLAGVTLQGLAASGYRVTCAIQVENWTRYALMYPTVDTFGNPGVTTAPTAILPTKKEAFATQKPQSTATGVSGTVSWELQGVGRRFVLMWAAPFNFNHFSNWIGVGMTREGLVDVAPGNTWFDQMYYDSNSDDLTFERGEFYDDLKPVIYRNDKFEVEGVMTNIHKAQIKVVIRPTIDNWRDMALPIQALLVQQEKEVCDMTTEHM------- A_0031_412 --------MGVPFPALKTMVTVFLLLMGNTSPVQP-AIVSGTISATVASIASSVITAGTSLAGTTLDTMADPNYSVTCAIQVENWTRYALMYPTVDTFGNPGVTTAPTAILPTKKEAFATQKPQSTATGVSGTVSWELQGVGRRFVLMWAAPFNFNHFSNWIGVGMTREGLVDVAPGNTWFDQMYYDSNSDDLTFERGEFYDDLKPVIYRNDKFEVEGVMTNIHKAQIKVVIRPTIDNWRDMALPIQALLVQQEKEVCDMTTEHM------- V_CG13_299 --------MGVPFPALKTMVTVFLLLMGNTSPVQP-AIVSGTIAATVASIASSVITVGTSLAGTTLERLADPNSRVTCTIQVENWTRYALMYPTVLTRGSPGVTTPPTAILPTKKEAFATRKPKSTATGVSGTVSWELQGTGRRFVLMWSAPFNFNHYSNWMGVGMTREGLVDVAPGNTWFDQMYYGSNSDNLTFERGEFYYNLKPVIYRNDKFEVEGVMTNIHKAQIKVVIRPTINNWWDMALPIQALLVDEKEEVCDMTTEHM------- A_1387_241 --------MAVPFPALKTMVTVFFVLMGNTSPVHPFAI-SV-SA--VASIASSVITAGTSLAGTSLNTLANQNSRVTCAIQVENWTRYALMYPTVDTLGNPGVMTAPTAILPTKKEAFAMRKPQYSTTGVSGTVSWELQGAGRLFVLMWSAPFNFDHHKNWMGVGMTREGLVDVASDDAWFEQMYNDGNSADLTFKRGKFNYDLKPVIYRNDKFEIVGVMTNIHKAQIRVVIRPTMNNWRDMALPIQALLVRQEERVCNMTTERM------- K_0010_399 --------MRVPFPALKTMVTVFLLLMGNTSPVHPAVI-SGTLAATVASIASSFITAGTSLAGTTLQNLADPTFSVSCTIQVENWTRYALVYPTVLLYGSPAVTSAPTAILPTKREAFAVRKPQSTATGVSGTVSWELQGANQRFVLMWAAPFNFNHHSNWMGVGMTREGLVNVVSGDTWFNQMYYGSNSDNLTFKRGRFYYNLNPIIYRNDKFEVVGVMTNIHKAEIKVVIRPTINNWKDLAFPVQALLVQQKEEVCSMTTEHM------- ermineusAXL95382 --------MGVPFPALKTMVTVFLLLMGNMSPV---VLQSSTPLSMVKAFAYEVVTPGSSLACNTVQDLVDTHHKVTVVIQVENWTRYRMMVPRLRIANDGASITNPVAILPGKREAFAVRMPSSGRKGVYGTVSWELIKANRRFVLMWSAPYDFNHHSNWLGLGMTGEGLVDVAAGNTWFDQMYYNSSNASLKFVRKKFYYNVDPFIYSNEKFEAEGEMTNGHKVWVRVIVRPSSNNWEDLAYVIRQKLD--------------------- andremeneziATF27386 --------MGVPFPALKTMVTVFLLLMGNTSPVHPVVLSSAISLSTVATIASGVISAGTSLAGVTLQGLAASGYRVTCTIQVENWTRYPLLYPSVRIANSGVLTTAPTAILPGKKEAFATRMPAHRAEGVYGTVSWEMHGTDRRFVLMWSAPFNFHFYSNWLGLGMTKEGVAGLARGNTWFDQMYYGGNSHDLTFEREEFKKRTDPVIYRNDKFEVVGIMTNIHRAQIKVIVRPTRNNWKDLADPIRLSLEQQQKRAL------QRDN---- magusQFQ61162 --------MGVPFPALKTMVTVFLLLMGNTSPVHPVVLSSLVSLGTVAGIASKVISAGSSLAGVGLQGLADPGYRVTCAIQVENWTRYPLVYPTVRVFGNGAVTSAPTAILPGKKEGFAVRKPSGTATGVSGTVSWEMHGASRRFVLGWSAPYSFDFHSNWMGLGITREGSFKVASGDTWFNQMYYGGNSANLTFETGEFYYDTDPVIYRNDNFEAVGVMTNIHKAQIKVVIRPTPNNWKDLAGPIRQLLVQQQRHALQQKRSLQRDN---- monileANC48005 --------MGVPFPALKTMVTVFLLLMGNASPVH-----SVISASLVASIASSVITAGTSVASTALQAVGGSSATVTCVIQVENWTRFALKYPTVLTNGAPPITNAPTAILPTKIEAFAVEKPRGTATGTSGTVSWELQGMEQRIVLMWSAPFSFDLYSNWMGVGMTREGLVDVASGDTWYKQMYYKDDSEDLTFERGKFYYNLKPVIYRNDKFEIVGTMTNIHKAQIKVIIRPTINNWKDMALPIQEMLVKQEKEVCNITTA--------- lividusATG85040 --------MGVPFPALKTMVTVFLLLMGNTSPV---VLGTSTPLSRVKLVASEVVTPGSSLACGLQQGMVATGYKVSCIIQVENWTRYPLMVPRLRIANDGAATTNPSAIAEAKREAFAVRKASGTATGVYGTVSWELQGANRRFVLMWSAPFDFNQHSNWLGLGMTREGLVDVAPGNTWFDQMYYDSNTEDLTFERKEFYSNTDSFIYSDNRFEVEGDMTNGHNAVIRVVVRPISDNWDDLAYEIRRKLN--------------------- ebraeusASF90529 --------MRVPFPALKTMVTVFLLLMGNMSPV---VPRSSIPLDKVKVLAYEVVTSGNSLNGVTLQDLAETEYDVTCVVQVENWTRYPLMTPRQRIANDGAWTTYPVAILPGKREAFAVRKASGVKKGVYGIVSWELLGARRRFVIMWSAPYDLNKYSNWMGLGMTREGLTDVAPGDTWFDQMYSDKSSGSLTFERKEFYHNTDPVIYRNAKFEAEGAMTNGNHAQVKIVVRPTRNNWKDLADEIRQKLV--------------------- consorsP0DKQ8 --------MGVQFPALKTMVTVFLLLMGNMSPV---VMKSSIPLRKVKMVASKVVTPGSSLYGVALKDLADTSYNITCTLQVENWIRYRLIVPSVQMVY-GVVTTTPIAIEPAKREAFAVRKTSDTASGVAGSVSWELEKARRRFVIMWSVPDNFNSFGYWMGLGMTREGLVD--PDKDWYGQMYSGSSDGDLTFTRKDFSYNTDSIIYSNDKFEVEGDMTNTQHAQIKIVIRPSSNNWKDLAPKIRRKLKKKPKPARQRDN---------- geographusJAB84575 --------MGVPFPALKTMVTVYLLLMGNMSPV---V-TSSTRLSRVREIASRVVTPGSSLHGVSLKDLAETKYGVTCAIQVENWTKFSLKDPKIQING-GVTTTTAIGIEPGKREAFAVRKTAGTATGASGTVSWELDGARRRFVIMWSVPYDFNLYSSWMAMGMTREGL--VAPNKNWFDQMYYHGNDGDLTFARKKVYHDTSSFIYSNDKFEAEGDMTNTYHAQVKVVIRPSSNKFKNLAPEILQELKEKR-------------PAPDS [Elevenin] [No Framework] [ /--------Signal----------/P/--C--------C---------------------------------------/------------------------------------------------] A_0031_440 -MAPSQKALLVLVL--SMLLTASDSRARRIDCTRFVYAPICRGVAAKRGGDSLSVGGSTEL-------------------------------------------------------------------- A_0885_184 -MAPSQKALLVLVL--SMLLTASDSRARRIDCTRFVYAPICRGVAAKRGGDSLSVGGSTELDDALTDPFLRSEEPREEDTEKKWRELSRLSRVLQILLSHPTGETEQLDRLLTL--------------- victoriaeA0A0F7YZQ7 -MAPSQKALLVLVL--SMLLTASDSWARRIDCKVFVFAPICRGVAAKRGGDSLSVGGSAELDDALTDPFLRSEEPRE------WRELTRLSRVLQTFLSHPTGETEQHD-------------------- CharoniaAQS80540 -MAVTSSSTGLLLLLLSVILAASVVSARRIDCTRFVFAPRCRGVAAKRGGHSLSVEDTTELDDTFTDSVLGMGEANRDEDSEKFLRLLLDLSRAIRQPITPSARGKELLERLLRS-------------- PomaceaXP_025088328 MMAQTSACRLLLLFFIVISAVSCIVSARRIDCTKFVFAPRCRGVAAKRGVMPLADDSTSQEDAYV-DP-LMQPEAGRDEESEKLLRLAMDLPHAVPDQSSASQKRRELLERLLRSYNIPEYSDAGYRQE [Ferritin] [Framework XIV] [ ---------------C----------------------------------------------C--------------------------------------------------------C--C-------------------------------/-----Po--------------] A_0855_240 ---------------------------------------------------------KAHEECGYAEKLMEYQNMRGGRILLQTVKKPDRDDWGSRLEALQAALQLEKSINQSMLELHQCASCHNDPQMGDFVEDSFLKEQVKTIKEISDYITNLKRVGTGLGEFIFDKETLQEKQE V_1278_185 M----SQVRQNFHEECEAAINRQINLQKYADYVYMSMSFYFDRDDVSLKGFHEFFKKKAHEECGYAEKLMEYQNMRGGRILLQTVKK------------------------------------------------------------------------------------------ A_0875_215 M----SQVRQNFHEECEAAINRQINLQKYADYVYMSMSFYFDRDDVSLKGFHEFFKKKAHEECGYAEKLMEYQNMRGGRILLQTVKKPDRDDWGSRLEALQAALQLEKSINQSMLELHQCASCHNDPQMGDFVEDNFLKEQVKTIKEISDYITNLKRVGTGLGEFIFDKETLQEKQE A_0039_292 M----SQVRQNFHEECEAAINRQINLQKYADYVYMSMSFYFDRDDVSLKGFHEFFKKKAHEECGYAEKLMEYQNMRGGRILLQTVKKPDRDDWGSRLEALQAALQLEKSINQSMLELHQCASCHNDPQMGDFVEDNFLKEQVKTIKEISDYITNLKRVGTGLGEFIFDKETLQEKQE A_0055_296 M----SQVRQNFHEECEAAINRQINLQKYADYVYMSMSFYFDRDDVSLKGFHEFFKKKAHEECGYAEKLMEYQNMRGGRILLQTVKKPDRDDWGSRLEALQAALQLEKSINQSMLELHQCASCHNDPQMGDFVEDNFLKEQVKTIKEISDYITNLKRVGTGLGEFIFDKETLQEKQE A_0885_177 M----SQVRQNFHEECEAAINRQINLQKYADYVYMSMSFYFDRDDVSLKGFHEFFKKKAHEECGYAEKLMEYQNMRGGRILLQTVKKPDRDDWGSRLEALQAALQLEKSINQSMLELHQCASCHNDPQMGDFVEDNFLKEQVETIKEISDYITNLKRVGTGLGEFIFDKETLQEKQE V_CG13_241 M----SQVRQNFHEECEAAINRQINLQKYADYVYMSMSFYFDRDDVSLKGFHEFFKKKAHEECGYAEKLMEYQNMRGGRILLQTVKKPDRDDWGSGLEALQAALQLEKSINQSMLELHQCASCHNDPQMGDFVEDNFLKEQVETIKEISDYITNLKRVGTGLGEFIFDKETLQEKQE V_1302_274 M----SQVRQNFHEECEAAINRQINLQKYADYVYMSMSFYFDRDDVSLKGFHEFFKKKAHEECGYAEKLMEYQNMRGGRILLQTVKKPDRDDWGSGLEALQAALQLEKSINQSMLELHQCASCHNDPQMGDFVEDNFLKEQVETIKEISDYITNLKRVGTGLGEFIFDKETLQEKQE V_1258_199 M----SQVRQNFHEECEAAINRQINLQKYADYVYMSMSFYFDRDDVSLKGFHEFFKKKAHEECGYAEKLMEYQNMRGGRILLQTVKKPDRDDWGSGLEALQAALQLEKSINQSMLELHQCASCHNDPQMGDFVEDNFLKEQVETIKEISDYITNLKRVGTGLGEFIFDKETLQEKQE A_0239_282 M----SQVRQNFHEECEAAINRQINLQKYADYVYMSMSFYFDRDDVSLKGFHEFFKKKAHEECGYAEKLMEYQNMRGGRILLQTVKKPDRDDWGSRLEALQAALQLEKSINQSMLELHQCASCHNDPQMGDFVEDNFLKEQVETIKEISDYITNLKRVGTGLGEFIFDKETLQEKQE A_0031_084 M----SQVRQNFHEECEAAINRQINLQKYADYVYMSMSFYFDRDDVSLKGFHEFFKKKAHEECGYAEKLMEYQNMRGGRILLQTVKKPDRDDWGSRLEALQAALQLEKSINQSMLELHQCASCHNDPQMGDFVEDNFLKEQVETIKEISDYITNLKRVGTGLGEFIFDKETLQEKQE A_0520_095 M----SQVRQNFHEECEAAINRQINLQKYADYVYMSMSFYFDRDDVSLKGFHEFFKKKAHEECGYAEKLMEYQNMRGGRILLQTVKKPDRDDWGSRLEALQAALQLEKSINQSMLELHQCASCHNDPQMGDFVEDNFLKEQVKTIKEISDYITNLKRVG------------------ A_0048_047 M----SQVRQNFHEECEAAINRQINLQKYADYVYMSMSFYFDRDDVSLKGFHEFFKKKAHEECGYAEKLMEYQNMRGGRILLQTVKKPDRDDWGSRLEALQAALQLEKSINQSMLELHQCASCHNDPQMGDFVEDNFLKEQVKTIKEISDYITNLKRVGTGLGEFIFDKETLQEKQE A_0025_198 M----SQVRQNFHEECEAAINRQINLQKYADYVYMSMSFYFDRDDVSLKGFHEFFKKKAHEECGYAEKLMEYQNMRGGRILLQTVKKPDRDDWGSRLEALQAALQLEKSINQSMLELHQCASCHNDPQMGDFVEDNFLKEQVKTIKEISDYITNLKRVGTGLGEFIFDKETLQEKQE A_1387_250 M----SQVRQNFHEECEAAINRQINLQKYADYVYMSMSFYFDRDDVSLKGFHEFFKKKAHEECGYAEKLMEYQNMRGGRILLQTVKKPDCDDWGSRLEALQAALQLEKSINQSMLELHQCASCHNDPQMGDFVEDNFLKEQVKTIKEISDYITNLKRVGTGLGEFIFDKETLQEKQE K_0010_357 M----SQVRQNFHEECEAAINRQINLQKYADYVYMSMSFYFDRDDVSLKGFHEFFKKKAHEECGYAEKLMEYQNMRGGRILLQTVKKPDRDDWGSGLEALQAALQLEKSINQSLLELHQYASCHNDPQMSDFVEDNFLKEQVETIKEISDYITNLKRVGTGLGEFIFDKETLQEKQE ermineusAXL95448 M----SQVRQNFHEECEAAINRQINLQKYADYVYMSMSFYFDRDDVSLKGFHEFFKKKAHEECGYAEKLMEYQNMRGGRILLQTVKKPDRDDWGSGLEALQAALQLEKSINQSMMELHQCASCHNDPQMSDFVEDNFLKEQVETIKEISDYITNLKRVGTGLGEFIFDKETLQEKQE magusQFQ61167 M----SQVRQNFHEECEAAINRQINLQKYADYVYMSMSFYFDRDDVSLKGFHEFFKKKAHEECGYAEKLMEYQNMRGGRILLQTVKKPDRDDWGSGLEALQAALQLEKSINQSMLELHQCASCHNDPQMGDFVEDNFLKEQVETIKEISDYITNLKRVGTGLGEFIFDKETLQEKQE A_0039_246 MA--VSQCRQNYHAECEAGINRQINMELHASYCYQSMAFYFDRDDVALFGFAKFFRKSSEEEREHAEKLMTFQNQRGGRIVLQDIKKPDRDEWGSGLDAMQVALALEK--------------------------------------------------------------------- A_0055_234 MA--VSQCRQNYHAECEAGINRQINMELHASYCYQSMAFYFDRDDVALFGFAKFFRKSSEEESEHAEKLMTFQNQRGGRIVLQDIKKPDRDEWGSGLDAMQVALALEKS-------------------------------------------------------------------- A_0855_176 MA--VSQCRQNYHAECEAGINRQINMELHASYCYQSMAFYFDRDDVALFGFAKFFRKSSEEEREHAEKLMTFQNQRGGRIVLQDIKKPDRDEWGSGLDAMQVALALEKSVNQSLLDLHDVATNHNDAQMTDFLEGNYLQEQVRSIKELGDYITNLKRVGPGLGEYMFDKETLQE--- A_0885_210 MA--VSQCRQNYHAECEAGINRQINMELHASYCYQSMAFYFDRDDVALFGFAKFFRKSSEEEREHAEKLMTFQNQRGGRIVLQDIKKPDRDEWGSGLDAMQVALALEKSVNQSLLDLHDVATNHNDAQMTDFLEGNYLQEQVRSIKELGDYITNLKRVGPGLGEYMFDKETLQE--- A_0875_146 MA--VSQCRQNYHAECEAGINRQINMELHASYCYQSMAFYFDRDDVALFGFAKFFRKSSEEEREHAEKLMTFQNQRGGRIVLQDIKKPDRDEWGSGLDAMQVALALEKSVNQSLLDLHDVATSHNDAQMTDFLEGNYLQEQVRSIKELGDYITNLKRVGPGLGEYMFDKETLQE--- V_1302_266 MA--VSQCRQNYHAECEAGINRQINMELHASYCYQSMAFFFDRDDVALPGFAKFFRKSSEEEREHAEKLMTFQNQRGGRIVLQDIKKPDRDEWGSGLDAMQVALALEKSVNQSLLDLHEVATNHNDAQMTDFLEGNYLQEQVRSIKELGDYITNLKRVGPGLGEYMFDKETLQE--- V_1278_120 MA--VSQCRQNYHAECEAGINRQINMELHASYCYQSMAFFFDRDDVALPGFAKFFRKSSEEEREHAEKLMTFQNQRGGRIVLQDIKKPDRDEWGSGLDAMQVALALEKSVNQSLLDLHEVATNHNDAQMTDFLEGNYLQEQVRSIKELGDYITNLKRVGPGLGEYMFDKETLQE--- V_1258_223 MA--VSQCRQNYHAECEAGINRQINMELHASYCYQSMAFFFDRDDVALPGFAKFFRKSSEEEREHAEKLMTFQNQRGGRIVLQDIKKPDRDEWGSGLDAMQVALALEKSVNQSLLDLHEVATNHNDAQMTDFLEGNYLQEQVRSIKELGDYITNLKRVGPGLGEYMFDKETLQE--- V_CG13_283 MA--VSQCRQNYHAECEAGINRQINMELHASYCYQSMAFFFDRDDVALPGFAKFFRKSSEEEREHAEKLMTFQNQRGGRIVLQDIKKPDRDEWGSGLDAMQVALALEKSVNQSLLDLHEVATNHNDAQMTDFLEGNYLQEQVRSIKELGDYITNLKRVGPGLGEYMFDKETLQE--- A_1387_054 MA--VSQCRQNYHAECEAGINRQINMELHASYCYQSMAFYFDRDDVALFGFAKFFRKSSEEEREHAEKLMTFQNQRGGRIVLQDIKKPDRDEWGSGLDAMQVALALEKSVNQSLLDLHDVATNHNDAQMTDFLEGNYLQEQVRSIKELGDYITNLKRVGPGLGEYMFDKETLQE--- A_0520_167 MA--VSQCRQNYHAECEAGINRQINMELHASYCYQSMAFYFDRDDVALFGFAKFFRKSSEEEREHAEKLMTFQNQRGGRIVLQDIKKPDRDEWGSGLDAMQVALALEKSVNQSLLDLHDVATNHNDAQMTDFLEGNYLQEQVRSIKELGDYITNLKRVGPGLGEYMFDKETLQE--- A_0048_065 MA--VSQCRQNYHAECEAGINRQINMELHASYCYQSMAFYFDRDDVALFGFAKFFRKSSEEEREHAEKLMTFQNQRGGRIVLQDIKKPDRDEWGSGLDAMQVALALEKSVNQSLLDLHDVATNHNDAQMTDFLEGNYLQEQVRSIKELGDYITNLKRVGPGLGEYMFDKETLQE--- A_0031_092 MA--VSQCRQNYHAECEAGINRQINMELHASYCYQSMAFYFDRDDVALFGFAKFFRKSSEEEREHAEKLMTFQNQRGGRIVLQDIKKPDRDEWGSGLDAMQVALALEK--------------------------------------------------------------------- A_0025_028 MA--VSQCRQNYHAECEAGINRQINMELHASYCYQSMAFYFDRDDVALFGFAKFFRKSSEEEREHAEKLMTFQNQRGGRIVLQDIKKPDRDEWGSGLDAMQVALALEKSVNQSLLDLHDVATNHNDAQMTDFLEGNYLQEQVRSIKELGDYITNLKRVGPGLGEYMFDKETLQE--- A_0239_153 MA--VSQCRQNYHAECEAGINRQINMELHASYCYQSMAFYFDRDDVALFGFAKFFRKSSEEEREHAEKLMTFQNQRGGRIVLQDIKKPDRDEWGSGLDAMQVALALEKSANQSLLDLHDVATNHNDAQMTDFLEGNYLQEQVRSIKELGDYITNLKRVGPGLGEYMFDKETLQE--- K_0010_064 MA--VSQCRQNYHAECEAGINRQINMELHASYCYQSMAFYFDRDDVALPGFAKFFRKSSEEEREHAEKLMTFQNQRGGRIVLQDIKKPDRDEWGSGLDAMQVALALEKSVNQSLLELHDVATNHNDAQMTDFLEGNYLQEQVRSIKELGDYITNLKRVGPGLGEYMFDKETLQE--- ermineusAXL95449 MA--VSQCRQNYHAECEAGINRQINMELHASYCYQSMAFYFDRDDVALPGFAKFFRKSSEEEREHAEKLMTFQNQRGGRIVLQDIKKPDRDEWGSGLDAMQVALALEKSVNQSLLDLHEVATSHNDAQMTDFLEGNYLQEQVRSIKELGDYITNLKRVGPGLGEYMFDKETLQE--- frigidusARU12137 MA--VSQCRQNYHAECEAGINRQINMELHASYCYQSMAFYFDRDDVALPGFAKFFRKSSEEEREHAEKLMTFQNQRGGRIVLQDIKKPDRDEWGSGLDAMQVALALEKSVNQSLLDLHEVATNHNDAQMTDFLEGNYLQEQVRSIKELGDYITNLKRVGPGLGEYMFDKETLQE--- monileANC47994 MA--VSQCRQNYHAECEAGINRQINMELHASYCYQSMAFYFDRDDVALPGFAKFFRKSSEEEREHAEKLMTFQNQRGGRIVLQDIKKPDRDEWGSGLDAMQVALALEKSVNQSLLDLHEVATNHNDAQMTDFLEGNYLQEQVRSIKELGDYITNLKRVGPGLGEYLFDKETLQE--- araneosusAQM52450 MA--VSQCRQNYHAECEAGINRQINMELHASYCYQSMAFYFDRDDVALPGFAKFFRKSSEEEREHAEKLMTFQNQRGGRIVLQDIKKPDRDEWGSGLDAMQVALALEKSVNQSLLDLHEVATSHNDAQMTDFLEGNYLQEQVRSIKELGDYITNLKRVGPGLGEYMFDKETLQE--- novaehollandiaeADC80508 -------------------VNRQINMELHASYCYQSMAFYFDRDDVALPGFAKFFRKSSEEEREHAEKLMTFQNQRGGRIVLQDIKKPDRDEWGSGLDATQVALALEKSVNQSLLDLHEVATNHNDAQMTDFLEGNYLQEQVRSIKELGDYITNLKRVGPGLGEYMFDKETLQ---- magusQFQ61169 MA--VSQCRQNYHAECEAGINRQINMELHASYCYQSMAFYFDRDDVALPGFAKFFRKSSEEEREHAEKLMTFQNQRGGRIVLQDIKKPDRDEWGSGLDAMQVALALEKSVNQSLLDLHEVATNHNDAQMTDFLEGNYLQEQVRSIKELGDYITNLKRVGPGLGEYMFDKETLQE--- A_0055_233 MALNVSQCRQNYHAESEAGVNRQINMELYASYCYQSMSFYFDRDDVALSGFAKYFKEASDEEREHAEKLMKFQNKRGGRIVLQDIKKPDRDEWGTGLDAMQVALGLEKS-------------------------------------------------------------------- A_0855_165 MALNVSQCRQNYHAESEAGVNRQINMELYASYCYQSMSFYFDRDDVALSGFAKYFKEASDEEREHAEKLMKFQNKRGGRIVLQDIKKPDRDEWGTGLDAMQVALGLEKSVNQALLDLHEVASNHKDAQMTDFLESEYLQEQVEAIKKIGDHITNLKRVGPGLGEYQFDKNLS----- A_0875_162 MALNVSQCRQNYHAESEAGVNRQINMELYASYCYQSMSFYFDRDDVALSGFAKYFKEASDEEREHAEKLMKFQNKRGGRIVLQDIKKPDRDEWGTGLDAMQVALGLEKSVNQALLDLHEVASNHKDAQMTDFLESEYLQEQVEAIKKIGDHITNLKRVGPGLGEYQFDKNLS----- A_0885_188 MALNVSQCRQNYHAESEAGVNRQINMELYASYCYQSMSFYFDRDDVALSGFAKYFKEASDEEREHAEKLMKFQNKRGGRIVLQDIKKPDRDEWGTGLDAMQVALGLEKSVNQALLDLHEVASNHKDAQMTDFLESEYLQEQVEAIKKIGDHITNLKRVGPGLGEYQFDKNLS----- A_0039_245 MALNVSQCRQNYHAESEAGVNRQINMELYASYCYQSMSFYFDRDDVALSGFAKYFKEASDEEREHAEKLMKFQNKRGGRIVLQDIKKPDRDEWGTGLDAMQVALGLENSVNQALLDLHEVASNHKDAQMTDFLESEYLQEQVEAIKKIGDHITNLKRVGPGLGEYQFDKNLS----- V_CG13_284 MALNVNQCRQNYHAESEAGVNRQINMELYASYCYQSMSFYFDRDDVALPGFAKYFKEASDEEREHAEKLMKFQNKRGGRIVLQDIKKPDRDEWGTGLDAMQVALGLEKSVNQALLDLHEVASNHKDAQMTDFLEGEYLQEQVEAIKKIGDYITNLKRVGPGLGEYQFDKNLS----- V_1302_234 MALNVNQCRQNYHAESEAGVNRQINMELYASYCYQSMSFYFDRDDVALPGFAKYFKEASDEEREHAEKLMKFQNKRGGRIVLQDIKKPDRDEWGTGLDAMQVALGLEKSVNQALLDLHEVASNHKDAQMTDFLEGEYLQEQVEAIKKIGDYITNLKRVGPGLGEYQFDKNLS----- V_1258_243 MALNVNQCRQNYHAESEAGVNRQINMELYASYCYQSMSFYFDRDDVALPGFAKYFKEASDEEREHAEKLMKFQNKRGGRIVLQDIKKPDRDEWGTGLDAMQVALGLEKSVNQALLDLHEVASNHKDAQMTDFLEGEYLQEQVEAIKKIGDYITNLKRVGPGLGEYQFDKNLS----- V_1258_245 MALNVNQCRQNYHAESEAGVNRQINMELYASYCYQSMSFYFDRDDVALPGFAKYFKEMSDEEREHAEKLMKFQNKRGGRIVLQDIKKPDRDEWGTGLDAMQVALGLEKSVNQALLDL------------------------------------------------------------ V_1278_125 MALSVNQCRQNYHAESEAGVNRQINMELYASYCYQSMSFYFDRDDVALPGFAKYFKEASDEEREHAEKLMKFQNKRGGRIVLQDIKKPDRDEWGTGLDAMQVALGLEKSVNQALLDLHEVASNHKDAQMTDFLEGEYLQEQVEAIKKIGDHITNLKRVGPGLGEYQFDKNLS----- V_1258_244 MALNVNQCRQNYHAESEAGVNRQINMELYASYCYQSMSFYFDRDDVALPGFAKYFKEASDEEREHAEKLMKFQNKRGGRIVLQDIKKPDRDEWGTGLDAMQVALGLEKSVNQALLELHKVATSHNDAQMTDFLEGEYLQEQVEAIKKIGDYITNLKRVGSGLGEYMFDKNLS----- A_1387_055 MALNVSQCRQNYHAESEAGVNRQINMELYASYCYQSMSFYFDRDDVALSGFAKYFKEASDEEREHAEKLMKFQNKRGGRIVLQDIKKPDRDEWGTGLDAMQVALGLEKSVNQALLDLHEVASNHKDAQMTDFLESEYLQEQVEAIKKIGDHITNLKRVGPGLGEYQFDKNLS----- A_0048_064 MALNVSQCRQNYHAESEAGVNRQINMELYASYCYQSMSFYFDRDDVALSGFAKYFKEASDEEREHAEKLMKFQNKRGGRIVLQDIKKPDRDEWGTGLDAMQVALGLEKSVNQALLDLHEVASNHKDAQMTDFLESEYLQEQVEAIKKIGDHITNLKRVGPGLGEYQFDKNLS----- A_0031_093 MALNVSQCRQNYHAESEAGVNRQINMELYASYCYQSMSFYFDRDDVALSGFAKYFKEASDEEREHAEKLMKFQNKRGGRIVLQDIKKPDRDEWGTGLDAMQVALGLEKSV------------------------------------------------------------------- A_0239_154 MALNVSQCRQNYHAESEAGVNRQINMELYASYCYQSMSFYFDRDDVALSGFAKYFKEASDEEREHAEKLMKFQNKRGGRIVLQDIKKPDRDEWGTGLDAMQVALGLEKSVNQALLDLHEVASNHKDAQMTDFLEGEYLQEQVEAIKKIGDHITNLKRVGPGLGEYQFDKNLS----- A_0025_243 MALNVSQCRQNYHAESEGGVNRQINMELYASYCYQSMSFYFDRDDVALSGFAKYFKEASDEEREHAEKLMKFQNKRGGRIVLQDIKKPDRDEWGTGLDAMQVALGLEKSVNQALLDLHEVASNHKDAQMTDFLEGEYLQEQVEAIKKIGDHITNLKRVGPGLGEYQFDKNLS----- A_0520_165 MALNVSQCRQNYHAESEAGVNRQINMELYASYCYQSMSFYFDRDDVALSGFAKYFKEASDEEREHAEKLMKYQNKRGGRVVLQDIKKPDRDEWGTGLDAMQVALGLEKSVNQALLDLHEVASNHKDAQMTDFLESEYLQEQVEAIKKIGDHITNLKRVGPGLGEYQFDKNLS----- A_0025_242 MALNVSQCRQNYHAESEAGVNRQINMELYACYCYQSMSFYFDRDDVALPGFAKYFKEASDEEREHAEKLMKFQNKRGGRIVLQDIKKPDRDEWGTGLDAMQVALGLEKSVNQALLDLHEVASNHKDAQMTDFLEGEYLQEQVEAIKKIGDHITNLKRVGPGLGEYQFDKNLS----- A_0025_244 ------------------------------------------------------------EEREHAEKLMKFQNKRGGRIVLQDIKKPDRDEWGTGLDAMQVALGLEKSVNQALLDLHKVAMDHNDAQMTDFLEGEYLQEQVEAIKKIGDHITNLKRVGCGLGEYMFDKNLS----- A_0520_166 ----------------------------------QSMSFYFGRDDVALPGFAKYFKEMSDEEREHAEKLMKYQNKRGGRVVLQDIKKPDRDEWGTGLDAMQVALGLEKSVNQALLELHKVATSHQDAQMTDFLESEYLQEQVEAIKKIGDHITNLKRVGPGLGEYQFDKNLS----- K_0010_139 ----------------------------------------FDRDDVALPGFAKYFKEMSDEEREHAEKLMKYQNKRGGRVVLQDIKKPDRDEWGTGLDAMQVALGLEKSVNQALLELHKVATSHQDAQMTDFLEGEYLQEQVESIKKIGDHITNLKRVGSGLGEYMFDKNLS----- ermineusAXL95451 MALNVSQCRQNYHAESEAGVNRQINMELYACYCYQSMSFYFDRDDVALPGFAKYFKEASDEEREHAEKLMKFQNKRGGRIVLQDIKKPDRDEWGTGLDAMQVALGLEKSVNQALLDLHKVAMDHNDAQMTDFLEGEYLQEQVEAIKKIGDHITNLKRVGCGLGEYMFDKNLS----- buxeusAMB57282 MALNVSQCRQNYHAESEAGVNRQINMELYASYCYQSMSFYFDRDDVALPGFAKYFKEASDEEREHAEKLMKFQNKRGGRVVLQDIKKPDRDEWGTGLDAMQVALGLEKSVNQALLDLHEVAASHKDAQMTDFLEGEYLQEQVESIKKIGDHITNLKRVGSGLGEYMFDKNLS----- AmadisKZ17799 ---NVSQCRQNYHAESEAGVNRQINMELYACYCYQSMSFYFDRDDVALPGFAKYFKEMXDEEREHAEKLMKFQNKRGGRIVLQDIKKPDRDEWGTGLDAMQVALGLEKSVNQALLDLHEVATSHKDAQMTDFLEGEYLQEQVESIKKIGDHITNLKRVGTGLGEYMFDKNLS----- magusQFQ61168 MALTVSQCRQNYHAESEAGVNRQINMELYACYCYQSMSFYFDRDDVALPGFAKYFKEASDEEREHAEKLMKFQNKRGGRIVLQDIKKPDRDEWGTGLDAMQVALGLEKSVNQALLDLHQVAMNHNDAQMTDFLEGEYLQEQVKAIKELGDHITNLKRVGTGLGEYMFDKNLS----- A_1387_359 M----SQVRQNFHKDCEAGINKQINLELYASYVYQQLAFHFSRDDVALPGFEKFFKENSEEEREHAERLMKFQNQRGGRIVLHDIPKPIKQDWSSGLEAMEAALELEKTVNQSLLDLHGLASTH----------------------------------------------------- A_0875_154 M----SQVRQNFHKDCEAGINKQINLELYASYVYQQLAFHFARDDVALPGFEKFFAENSKEEREHAEKLMKLQNQRGGRIVLQDIPKPVKQDWSSGLEAMEAALELEKTVNQSLLDLHTLAMGH----------------------------------------------------- V_1278_114 --------------------------------------------------------------REHAERLMKFQNQRGGRIVLQDIPKPVKQDWSSGLEAMEAALELEKTVNQSLLDLHTLAMGHNDPQFADFIETHYLTEQVEAIKQLADYVTNLRRV------------------- A_0885_218 --------------------------------------------------------------REHAEKLMKLQNQRGGRIVLQDIPKPVKQDWSSGLEAMEAALELEKTVNQSLLDLHTLAMGHNDPQFADFIETHYLTEQVEAIKQLGDYVTNLRRVGSGLGEYLFDKNTLG---- A_0885_219 --------------------------------------------------------------REHAEKLMKLQNQRGGRIVLQDIPKPVKQDWSSGLEAMEAALELEKTVNQSLLDLHGLAMGHNDPQFADFIETHYLTEQVEAIKQLGDYVTNLRRVGSGLGEYLFDKNTLG---- A_0520_324 M----SQVRQNFHKDCEAGINKQINLELYASYVYQQLAFHFARDDVALPGVEKFFAENSKEEREHAEKLMKLQNQRGGRIVLQDIPKPVKQDWSSGLEAMEAALELEKTVNQSLLDLHTLAMGHNDPQFADFIETHYLTEQVEAIKQLGDYVTNLRRVGSGLGEYLFDKNTLG---- ermineusAXL95670 M----SQVRQNFHKDCEAGINKQINLELYASYVYQQLAFHFARDDVALPGFEKFFAENSKEEREHAEKLMKLQNQRGGRIVLQDIPKPVKQDWSSGLEAMEAALELEKTVNQSLLDLHTLAMGHNDPQFADFIETHYLTEQVEAIKQLGDYVTNLRRVGSGLGEYLFDKNTLG---- [Kazal protease inhibitor-1] [Serine protease] [New Framework] [ /----Signal-------/---C-----C-------C----------C------C----------------C-C---C-------C---------------C------C------------C--------] /---------------Kazal FS domain----------------/ V_1258_264 MKTAVCVFLTVLALAHG--WTEEECDGICTANYEPYCLTFQKTVSNKCMRDIEICKMRAKGYTLTSSADNG----------------------------------------------------------- V_CG13_268 -----------------------------------YCLTFQKTVSNKCMGDIEICKMRAKGYTLTSSADNGCQCNIGCTMDYDPVCGLDLDANTTTAYGNACAFKTE-CNGTRLVEVPMDQC-------- A_0239_041 -----------------------ECEGGCTDNYEPYCLTFQKTVSNKCMGDIEICKMRAKGYTLTSSADNGCQCNIGCTMEYDPVCGLDLDANTTTAYGNACAFRTE-CNGTRLVEVPMDQC-------- A_0239_040 -----------------------ECEGGCTDNYEPYCLTFQKTVSNKCMGDIEICKMRAKGYTLTSSADNGCQCNIGCTMEYDPVCGLDLDANTTTAYGNACAFKTE-CNAKRLVEVPMDQC-------- A_0875_158 MKTAVCLFLTVLALAHG--WTEEECEGGCTANYEPYCLTFQKTVSNECMGNIEICKMRAKGYTLTSSADNGCQCNISCTTEYDPVCGLDLDANTTTAYGNACAFKTE-CNAKRLVEVPMDQC-------- A_0055_335 -----------------------ECEGGCTDNYEPYCLTFQKTVSNKCMGDIEFCKMRAKGYTLTSSADNRCQCNIGCTMEYKPVCGLDLNTNTTTEYGNACAFRTE-CNGTRLVEVPMDQC-------- A_0885_260 MKTAVCLFLTVLALAHG--WTEEECDGICTANYEPYCLTFQKTVSNECMGDIEICKMRAKGYTLTSSADNGCQCNIGCTMEYKPVCGLDLNTNTTTEYGNACAFRTE-CNGTRLVEVPMDQC-------- A_0875_159 MKTAVCLFLTVLALAHG--WTEEECDGICTANYEPYCLTFQKTVSNECMGDIEICKMRAKGYTLTSSADNGCQCNIGCTMEYKPVCGLDLNTNTTTEYGNACAFRTE-CNGTRLVEVPMDQC-------- A_0039_226 MKTAVCVFLTVLALAHG--WTEEECDGICTANYEPYCLTFQKTVSNECMGDIEICKMRAKGYTLTSSADNGCQCNIGCTMEYKPVCGLDLNTNTTTEYGNACAFRTE-CNGARLVEVPKDQC-------- A_0025_129 MKTAVCVFLTVLALAHG--WTEEECDGICTANYEPYCLTFQKTVSNECMGDIEICKMRAKGYTLTSSADNRCQCNIGCTMEYKPVCGLDLNTNTTTEYGNACAFRTE-CNGTRLVEVPMDQC-------- A_0039_215 MKTAVCVFLTVLALAHG--WTEEECDGICTANYEPYCLTFQKTVSNECMGDIEICKMRAKGYTLTSSADNGCQCNIGCTMEYKPVCGLDLNTNTTTEYGNACAFRTE-CNGARLVEVPKDQC-------- ermineusAXL95397 MKTAVCVFLTVLALAHG--WTEEECDGICTANYEPYCLTFQKTVSNECMGDIEICKMRAKGYTLTSSADNRCQCNIGCTMEYKPVCGLDLNTNTTTEYGNACAFRTE-CNGTRLVEVPMDQC-------- A_0025_128 -----------------------------------------KTVPNKCAGDIEICKMRAKGYTVTSSSNGTCTCSSVCTADYNPVCAVDLNTEETQMYPNQCTLNLAVCQGKRLGKVSMDKC---PVPLE A_0039_273 -----------------------------------------KTVPNKCAGDIEICKMRAKGYTVTSSSNGACTCSSVCTADYNPVCAVDLNTEETQMYPNQCTLNLAVCQGKRLGKVSMDKC---PVPLE A_0239_274 -------------------------------------VTFQKTVPNKCAGDIEICKMRAKGYTVTSSSNDACTCSSVCTADYNPVCAVDLNTEETQMYPNQCTLNLAVCQGKRLGKVSMDKC---PVPLE A_0875_161 MKTAVCVFLTVLAMVHASTWTEQQCGAACPMNFDPYCVTFQKTVPNKCAGDIEICKIRAKGYTVTSSSNGACTCSSVCTADYNPVCAVDLNTEETQMYPNQCTLNLAVCQGKRLGKVSMDKC---PVPLE V_CG13_293 MKTAVCVFLTVLAMVHAGTWTEQQCDGACPMNFDPYCVTFQKTVPNKCAGDIEICKMRAKGYTVTSSSNGVCTCSPVCTADYNPVCAVDLNTEETQMYPNQCTLNLAVCQGKRLGKVSMDKC---PVPLE A_0055_368 MKFVACVFLTVLALVHGSDWTEEKCSKGCPRNYDPHCLTFQKTAPNKCAGDIEICKMRAQGYSLTSTSQKSCECSPVCTDEYNPICAVDLN------------------------------------- A_0055_317 MKTAVCVFLTVLAMVHASTWTEQQCGAACPMNFDPYCVTFQKTVPNKCAGDIEICKMRAKGYTVTSSSNGACTCSSVCTADYNPVCAVDLNTEETQMYPNQCTLNFAVCQGKRLGKVSMDKC---PVPLE A_0885_259 MKTAVCVFLTVLAMVHASTWTEQQCGAACPMNFDPYCVTFQKTVPNKCAGDIEICKMRAKGYTVTSSSNGACTCSSVCTADYNPVCAVDLNTEETQMYPNQCTLNLAVCQGKRLGKVSMDKC---PVPLE V_CG13_292 MKTAVCVFLTVLALAH--GWTEEECDGICTANYEPYCLTFQKTVSNKCMGDIEICKMRAKGYTVTSSSNGVCTCSPVCTADYNPVCAVDLNTEETQMYPNQCTLNLAVCQGKRLGKVSMDKC---PVPLE V_CG13_294 MKTAVCVFLTVLALAH--GWTEEECEGGCTANYEPYCLTFQKTVSNKCMGDIEICKMRAKGYTVTSSSNGVCTCSPVCTADYNPVCAVDLNTEETQMYPNQCTLNLAVCQGKRLGKVSMDKC---PVPLE A_0031_149 MKTAVCVFLTVLAMVHASTWTEQQCGAACPMNFDPYCVTFQKTVPNKCAGDIEICKMRAKGYTVTSSSNDACTCSSVCTADYNPVCAVDLNTEETQMYPNQCTLNLAVCQGKRLGKVSMDKC---PVPLE A_0031_150 MKTAVCVFLTVLALAHG--WTEEECDGICTANYEPYCLTFQKTVSNECMGDIEICKMRAKGYTVTSSSNGTCTCSSVCTADYNPVCAVDLNTEETQMYPNQCTLNLAVCQGKRLGKVSMDKC---PVPLE K_0010_443 ------------------------------------CLTFQKTVPNKCAGDIESCAMRAKGYAVTSTSQKSCECSPICTAEYNPICAVDLNSDQKKVYGNPCELNNAVCQG------------------- A_0055_318 MQTVLCVFLAALALVHGSAWTEQKCDRACTREYKPHCVKFQKTVPNKCAGDIEICKMRAQGYTVTSSTNGTCTCSSICTMEYNPVCAMDLDTSTTTKFGNPCGLNLAVCKGKRMGEVPLNTC---PELFE V_CG13_301 MQTVLCVFLTALALVHGSAWTEEKCDRACTREYKPHCVTFQKTVPNKCAGDIEICKMRAQGYTVTSSTNGTCTCSPICTMEYNPVCAMDLDTSTTTKFGNPCGLNLAVCKGKRMGEVPLNTC---PELFE V_1302_230 MQTVLCVFLSALALVHGSAWTEEKCDRACTREYKPHCVTFQKTVPNKCAGDIEICKMRAQGYTVTSSTNGTCTCSPICTMEYNPVCAMDLDTSTTTKFGNPCGLNLAVCKGKRMGEVPLNTC---PELFE A_0885_258 MQAVLCVFLAALALVHGSAWTEEKCDRACTMEYKPHCVKFQKTVPNKCAGDIEICKMRAQGYTVTSSTNGTCTCSSICTMEYNPVCAMDLDTSTTTKFGNPCGLNLAVCKGKRMGEVPLNTC---PELFE A_0875_160 MQTVLCVFLAALALVHGSAWTEQKCDRACTREYKPHCVKFQKTVPNKCAGDIEICKMRAQGYTVTSSTNGTCTCSSICTMEYNPVCAMDLDTSTTTKFGNPCGLNLAVCKGKRMGEVPLNTC---PELFE A_0039_274 MQTVLCVFLAALALVHGSAWTEEKCDRACTREYKPHCVKFQKTVPNKCAGDIEICKMRAQGYTVTSSTNGTCTCSSICTMEYNPVCAMDLDTSTTTKFGNPCGLNLAVCKGKRMGEVPLNTC---PELFE V_CG13_302 MQTVLCVFLTALALVHGSAWTEEKCDRACTMEYEPHCVTFQKTVPNKCAGDIEICKMRAQGYTVTSSTNGTCTCSPICTMEYNPVCAMDLDTSTTTKFGNPCGLNLAVCKGKRMGEVPLNTC---PELSE A_0520_327 MQAVLCVFLAALALVHGSAWTEEKCDRACTMEYKPHCVKFQKTVPNKCAGDIEICKMRAQGYTVTSSTNGTCTCSSICTMEYNPVCAMDLDT-------------------------------------- A_0239_034 MKTAVCVFLTVLAMVHASTWTEQQCGAACPMNFDPYCVTFQKTVPNKCAGDIEICKMRAQGYTVTSSTNGTCTCSSICTMEYNPVCATDLDTGTTTKFGNPCGLNLAVCKGKRMGEVPLNTC---PELFE A_0025_131 MQTVLCVFLAALALVHGSAWTEQKCDRACTREYKPHCVKFQKTVPNKCAGDIEICKMRAQGYTVTSSTNGTCTCSSICTMEYNPVCAMDLDTSTTTKFGNPCGLNLAVCKGKRMGEVPLNTC---PELFE A_0031_148 MQTVLCVFLAALALVHGSAWTEQKCDRACTREYKPHCVKFQKTVPNKCAGDIEICKMRAQGYTVTSSTNGTCTCSSICTMEYNPVCAMDLDTGTTTKFGNPCGLNLAVCKGKRMGEVPLNTC---PELFE A_0239_035 MQTVLCVFLAALALVHGSAWTEQKCDRACTREYKPHCVKFQKTVPNKCAGDIEICKMRAQGYTVTSSTNGTCTCSSICTMEYNPVCATDLDTGTTTKFGNPCGLNLAVCKGKRMGEVPLNTC---PELFE K_0010_053 MQTVLCVFLTALALVHGSAWTEEKCTRACTMEYEPHCVTFRKTVPNKCAGDIEICKMRAQGYTVTSSTNGNCTCSPICTMEYNPVCAMDLDTSTTTKFGNPCGLNLAVCQGKRMGEVPLNTC---PELFE ermineusAXL95542 MQTVLCVFLAALALVHGSAWTEQKCDRACTMEYEPHCVKFQKTVPNKCAGDIEICKMRAQGYTVTSSTNGTCTCSSICTMEYNPVCAMDLDTSTTTKFGNPCGLNLAVCKGKRMGEVPLNTC---PELFE V_CG13_300 -------------------------------------------------GDIESCKMRAQGYSLTSTSQKACECSPVCTEEYNPICAVDLNSDQKKVYGNPCELNNAVCQGAQLGEMDLKSCEPVPELFD A_0885_261 ----------------------------------PHCLTFQKTAPNKCAGDIEICKMRAQGYSLTSTSQKSCECSPVCTDEYNPICAVDLNSDQKKVYGNPCELNNAVCQGAQLGEMDLKSCEPVPELFD A_0039_275 ----------------------------------PHCLTFQKTAPNKCAGDIEICKMRAQGYSLTSTSQKSCECSPVCTDEYNPICAVDLNSDQKKVYGNPCELNNAVCQGAQLGEMDLKSCEPVPELFD A_0025_132 ----------------------------------PHCVKFQKTVPNKCAGDIEICKMRAQGYSLTSTSQKSCECSPVCTDEYNPICAVDLNSDQKKVYGNPCELNNAVCQGAQLGEMDLKSCEPVPELFD [Kazal protease inhibitor-2] [Serin protease] [Also a Turripeptide] [Framework IX] [ /------Signal------/Pro-//--C---C-------C----------C------C-------------C] /------------Kazal FS domain----------------/ V_1302_304 MKTYCLLIVLLVGVAIQVEGQLDS--K CPMICPMNYAPVCGSDGQTYSNECSLNTKSCMSGRSITILHDGQC V_1258_261 MKTYCLLIVLLVGVAIQVEGQLDS--K CPMICPMNYAPVCGSDGQTYSNECSLNTKSCMSGRSITILHDGQC V_CG13_311 MKTYCLLIVLLVGVAIQVEGQLDS--K CPMICPMNYAPVCGSDGQTYSNECSLNTKSCMSGRSITILHDGQC A_0885_191 MKTYCLLIVLLVGVAIQVEGQLDS--K CPMICPMNYAPVCGSDGQTYSNECSLKTKSCMSGRSITILHDGQC A_0055_338 MKTYCLLIVLLVGVAIQVEGQLDS--K CPMICPMNYAPVCGSDGQTYSNECSLKTKSCMSGRSITILHDGQC K_0010_435 MKTYCLLIVLLVGVAIQVEGQLDS--K CSMICPMNYAPVCGSDGQTYSNECTLKTKSCMSGRSITILHDGQC magusQFQ61188 MKTYCLLIVLLVGVAIQVEGQLELNTK CPMMCPMNYAPVCGSDGETYPNACALNTKACTSGRSIIILHDGQC GemmulasogodensisP0DKT2 MKVYCLLLVLLVGLVSQAHGQLDK--K CQMVCTMDYRPVCGSDGRTYPNKCTLTSTACMSQRSITVFHDGEC GemmulaspeciosaP0DKT3 MKVYCLLLVLLVGLVSQAHGQLDK--K CQMVCTFDYRPVCGSDGRTYPNKCTLTSTACMSQRSITVFHDGEC PolystiraalbidaP0DKT1 MKVYCLLVVLLVGLVSQTQGQLDK--K CNMACTLDYRPVCGSDGKTYPNRCALTSTACESQQSITVLHDGEC [Lysozyme] /-----------------------------------------------------------------------------------------------G-type lysozyme domain---------------------------------------------------------------/ A_0885_204 MKWVGFLVWCGLLFCVR------------------------------------------------------------------------------------------GSSHSSGGYNCYGNFMNLRPTGASAQTASQDGIRRGGVSASQTMVTNDINELNKRKSCYTQAGNNNCVHPAVIAGIASRESRGGAAIERTGGWGDNHNAYGIMQCDGGASGLGS-RCTRYPWNSCEHINMMVETLLVPYIRNMQSKHRSWAPEQQLQGAVSAYNAGTGNVRTFSRMDEGTTGNDYSNDVMARAQYLVTRFRW- A_0039_229 MKWVGFLVWCGLLFCVR------------------------------------------------------------------------------------------GSSHSSGGYNCYGNFMNLRPTGASAQTASQDDIRRGGVSASQTMVTNDINELNKRKSCYTQAGNNNCVHPAVIAGIASRESRGGAAIERTGGWGDNHNAYGIMQCDGGASGLGS-RCTRYPWNSCEHINMMVETLLVPYIRNMQSKHRSWAPEQQLQGAVSAYNAGTGNVRTFSRMDEGTTGNDYSNDVMARAQYLVTRFRW- V_1278_132 MKWVGFLVWCGLLFCVR------------------------------------------------------------------------------------------GSSHSSGGYNCYGNFMNLRPTGASAQTASQDGIGDGGVSASQRMVSNDINELNKRKSCYIQAGNNNCVHPAVIAGIASRESRGGALIERTGGWGDNHNAYGIMQCDGGASGLGS-RCTSYPWNSCEHINMMVQILLVPYIRTMQSKHRSWAPEQQLQGAVSAYNAGTGNVRTFSRMDEGTTGNDYSNDVMARAQYLVNRFRW- A_0885_205 MKWVGFLVWCGLLFCVRGSDVPCRQAGGACQDNSRHCSGSYRRNMCAGSASRQCCIPRSASS---------------------------------------------GSSHSSGGYNCYGNFMNLRPTGASAQTASQDGIRRGGVSASQTMVTNDINELNKRKSCYTQAGNNNCVHPAVIAGIASRESRGGAAIERTGGWGDNHNAYGIMQCDGGASGLGS-RCTRYPWNSCEHINMMVETLLVPYIRNMQSKHRSWAPEQQLQGAVSAYNAGTGNVRTFSRMDEGTTGNDYSNDVMARAQYLVTRFRW- A_0039_228 MKWVGFLVWCGLLFCVRGSDVPCRQAGGACQDNSRHCSGSYRRNMCAGSASRQCCIPRSSSS---------------------------------------------GSSHSSGGYNCYGNFMNLRPTGASAQTASQDDIRRGGVSASQTMVTNDINELNKRKSCYTQAGNNNCVHPAVIAGIASRESRGGAAIERTGGWGDNHNAYGIMQCDGGASGLGS-RCTRYPWNSCEHINMMVETLLVPYIRNMQSKHRSWAPEQQLQGAVSAYNAGTGNVRTFSRMDEGTTGNDYSNDVMARAQYLVTRFRW- A_0055_281 MKWVGFLVWCGLLFCVRGSDVPCRQAGGACQDNSRHCSGSYRRNMCAGSASRQCCIPRSASS---------------------------------------------GSSHSSGGYNCYGNFMNLRPTGASAQTASQDDIRRGGVSASQTMVTNDINELNKRKSCYTQAGNNNCVHPAVIAGIASRESRGGAAIERTGGWGDNHNAYGIMQCDGGASGLGS-RCTRYPWNSCEHINMMVETLLVPYIRNMQSKHRSWAPEQQLQGAVSAYNAGTGNVRTFSRMDEGTTGNDYSNDVMARAQYLVTRFRW- A_0875_189 MKWVGFLVWCGLLFCVRGSDVPCRQAGGVCQDNSRHCSGSYRRNMCAGSASRQCCLPRSASS---------------------------------------------GSSHSSGGYNCYGNFMNLRPTGASAQTASQDGIRRGGVSASQTMVTNDINELNKRKSCYTQAGNNNCVHPAVIAGIASRESRGGAAIERTGGWGDNHNAYGIMQCDGGASGLGS-RCTRYPWNSCEHINMMVETLLVPYIRNMQSKHRSWAPEQQLQGAVSAYNAGTGNVRTFSRMDEGTTGNDYSNDVMARAQYLVTRFRW- V_CG13_219 MKWVGFLVWCGLLFCVRGSDVPCRQAGGTCQYNSRHCSGSYRRNMCAGSASRQCCIPRSASS---------------------------------------------GSSHSSGGYNCYGNFMNLRPTGASAQTASQDGIGDGGVSASQRMVSNDINELNKRKSCYIQAGNNNCVHPAVIAGIASRESRGGAVIERTGGWGDNHNAYGIMQCDGGASGLGS-RCTSYQWNSCEHINMMVEILLVPYIRTMQSKHRSWAPEQQLQGAVSAYNAGTGNVRTFSRMDEGTTGNDYSNDVMARAQYLVNRFRW- V_1278_133 MKWVGFLVWCGLLFCVRGSDVPCRQAGGTCQYNSRHCSGSYRRNMCAGSASRQCCIPRSASS---------------------------------------------GSSHSSGGYNCYGNFMNLRPTGASAQTASQDGIGDGGVSASQRMVSNDINELNKRKSCYIQAGNNNCVHPAVIAGIASRESRGGALIERTGGWGDNHNAYGIMQCDGGASGLGS-RCTSYPWNSCEHINMMVQILLVPYIRTMQSKHRSWAPEQQLQGAVSAYNAGTGNVRTFSRMDEGTTGNDYSNDVMARAQYLVNRFRW- A_0239_046 MKWVGFLVWCGLLFCVRGSDVPCRQAGGVCQDNSQHCSGSYRGNMCAGPASRQCCIHRSASS---------------------------------------------GSSHSSGGYNCYGNFMNLRPTGASAQTASQDGIRRGGVSASQTMVTNDINELNKRKSCYTQAGNNNCVHPAVIAGIASRESRGGAAIERTGGWGDNHNAYGIMQCDGGASGLGS-RCTRYPWNSCEHINMMVETLLVPYIRNMQSKHRSWAPEQQLQGAVSAYNAGTGNVRTFSRMDEGTTGNDYSNDVMARAQYLVTRFRW- A_0031_397 MKWVGFLVWCGLLFCVRGSDVPCRQAGGACQDNSQHCSGSYRGNMCAGPASRQCCIHRSASS---------------------------------------------GSSHSSGGYNCYGNFMNLRPTGASAQTASQDGIRRGGVSASQTMVTNDINELNKRKSCYTQAGNNNCVHPAVIAGIASRESRGGAAIERTGGWGDNHNAYGIMQCDGGASGLGS-RCTRYPWNSCEHINMMVETLLVPYIRNMQSKHRSWAPEQQLQGAVSAYNAGTGNVRTFSRMDEGTTGNDYSNDVMARAQYLVTRFRW- A_0048_319 MKWVGFLVWCGLLFCVRGSDVPCRQAGGACQDISRHCSGSYRRNMCAGSASRQCCIPRSASS---------------------------------------------GSSHSSGGYSCYGNFMNLRPTGASAQTASQDGIRRGGVSASQTMVTNDINELNKRKSCYTQAGNNNCVHPAVIAGIASRESRGGAAIERTGGWG------------------------------------------------------------------------------------------------------------- K_0010_431 MKWVGFLVWCGLLFCVRGSDVPCRQAGGTCQHNSGYCSGSYRRNMCAGSARRQCCIPRSASS---------------------------------------------G----SGGYNCYGNFMNLQPTGAXXXTASQDGIRHGGVSASQRMVSNDINELNKRKSCYIQAGNNNCVHPAVIAGIASRESRGGAVIERTGGWGDNHNAYGIMQCDGRASGLGS-RCTMYPWNSCEHINMMIEVLLVPYIRTMQSKHRSWAPEQQLQGAVSAYNAGTGNVQTFSRMDEGTTGNDYSNDVMARAQYLVNHYGW- betulinusALM87513 MKWVSFLVWCGLLFCVRGSDVPCRQAGGTCQHNSLYCSGSYQRNMCAGSVRRQCCIPRRASS---------------------------------------------GSSHGSGGYNCYGNFMNLRPTGASAQTASQDGIRHGGVSASQTMVANDINELNKRKSCYIRAGNNNCVHPAVIAGIASRESRGGAFIERTGGWGDNHNAYGIMQCDGGASGLGE-LCTRYPWDSCEHINMMVEILLVRDIRTIRSKHPSWAPEQQLQGAVSAYNAGTGNVRSFRRMDVGTTGNDYSNDVMARAQYLVNRFGW- magusQFQ61173 MKWVGFLVWCGLLFCVRGSDVPCRQAGGTCQHNSLYCSGSYRRNMCAGSARRQCCIPSRASSGSDTPCINQGGTCQYDHLQCTGQYQSYLCSGAANRRCCIPSRSSSGSSPSSGNYNCYGNFMNLHPTGASAQTARQDRIRQGGVSASQRMVANDIRELRKRKSCYIQAGNNNCVHPAVIAGIASRETRGGAIIERTGGWGDNHNAYGIMQCDGGASGLGEEVCTRYLWNSCEHINMMVEILLVPYIRTIQSKHPSWAPEQQLQGAVSAYNAGTGNVRTFDRMDVGTTGNDYSNDVMARAQYLVSRFGW- LottiaXP_009046473 ---------------------------------------------------------------------------------------------------------------------CHGDVMKLHPTGASSRTASQDGIHYGGAQASYKMLDNDLAELNKRKSCYVQAGTNNCVHPAVIAAVASRETRGGKLLYRTGGWGDNHRAWGIMQCDLHASGLGS-QCTKYGWDSCAHIDMMTRVILVPYMDQVKRKHPTWSAENQLKGGVSAYNAGVGNVGTVARMDIGTTGNDYSNDVIARAQRLITSHGW- HaliotisAOX15708 MRTFLLLTIAVAAVNGDACTSHVLTGTHAGTQGVGCMEASCCANGFMMASLCAGNDVCCFSH---------------------------------------------DSCGSSSKYNCYGDVMKLRPTGASSRTSSGLGYSGVQASNHMVDQDYA--ELNKRKSCYVRAGANNCIHPAVVAGVASRETRGGKLLYSTGGWGDHHHAWGIMQCDVYASGLGS-TCERYAWDSCDHIDQMTRIILVPYIKQVKAKHPTWSPEQQMQGGVSAYNAGVGNVATWSHLDVGTTGNDYSNDVIARAQHLINQHGW- AplysiaP_012938414 MILFLVLTSLGVAYGTNYK--------------------------------------------------------------------------------------------------CHGNVMVLTVSGASSSTARQDGLSTGGLQSSYKMADNDYSELNKRKTCYYQAGKNNCIQPAVVAALASRESRGGKLLYRTKGYGDGYHAYGILQCDGGASGLHS-KCTQYAWDSCAHIDFMVKTLLVPYINQVKAKHPTWTQDQALKGGISAYNAGVGNVQTYAGMDLGTTGNDYANDVCARAQRLISHYHWE [Neuropeptide F] [No Signal, No Framework] A_0885_181 MHKALLSALLVISLVVAEVT-CQEAMLAPPDRPQEFRSPGELRRYLKALNEYYAIVGRPRFGRSVNTNKRSV--EELGDLK--S-D-E V_CG13_213 MQKALLSALFVISLV---VT-CD--SQDPPVRPEVFRTPNELRQYLKDLNEYFAIVGRPRFGRSVNTNKRSV--EELGDLT--S-D-E A_0039_247 MLKALLSALFVISLMVAEVT-CD--PSGPPVRPKVFRTLEELRQYLKDLNEYFAIVGRPRFGRSINTNKRSV--EELGDLT--S-D-E A_0039_248 MPKALLSALFVISLMVAEVT-CD--PSGPPVRPKVFRTLEELRQYLKDLNEYFAIVGRPRFGRSINTNKRSV--EELGDLT--S-D-E A_0031_167 MPKALLSALFVISLVVAEVT-CDF--FGPPVRPKYFHTVDELHQYLMDLNNYYAVLGRPRFGRSINTNKRSV--EELGDLT--S-D-E A_1387_229 MPKALLSALFVISLMVAEVT-CDP--FGPPVRPKVFRSAEELRQYIQDINIYYAIVGRPRFGRSINTNKRSV--EELGDLT--S-D-E K_0010_001 MHKALLSALLVISLVVAEVT-CQEAMLAPPDRPQEFRSPEELRRYLKALNEYYAIVGRPRFGRSVNTNKRSV--EDLGDLK--S-D-E magusQFQ61175 MQKAQLSALLVISLVVAQMT-CVH-SLRRPQRPARFTSVAQLRRYLRALNEYYAIVGRPRFGRNVDSNKKSV--KDLGDLK--P-N-E praecellensATF27584 MQKALLSALLVISLVVVEVTRQKVVKPVEPVKPDKFKSIVELEAYLEKLNDYYRILSKPRFGRSLNISKRSR--KEHGALR--S---- betulinusP0CJ22 -----------------------TV-SDPPARPAVFHSREELMNYVRELNRYFAIVGRPRF--------------------------- HaliotisdiscusAVW85486 MQKLVIAVLLVFSLVVMEVT-CQDAMLAPPDRPSEFRSPDQLRQYLKALNEYYAIVGRPRFGRSV--NKRSVNDAVFGEAT--K-T-E LottiagiganteaAFW19651 MQKLVLSLLILAAVVMLEVT-SQDSMLAPPDRPSEFRSPDELRRYLKALNEYYAIVGRPRFGRSV--NKRSAADYLFKPSH--K-N-E octopusbimaculoidesXP014777727 MQKIIITLLLVGIMFAMQVS-CQESMLAPPNRPSEFRSPEELRKYLKALNEYYAIVGRPRFGRSV--SKR-AASNTFAEALTAKRNDE MizuhopectenyessoensisXP_021372816 MQKFVLTTVLIVCALLVSQVTCQEAMLEPPDRPHSFRTPDQLRSYLRALNEYYSIVGRPRFGRSV--NKRSL--ESSLFNTEDLNTGE [Protein Disulfide Isomerase (PDI-A2)] /------------------------------------Thioredoxin (YbbN) domain-----------------------------------------------/ /----------------------------------------PDI_a_PDI_a'_C domain---------------------------------------/ A_0875_220 MKFSSCLVLTLLVFVSAEDVKQEEGVYVLTTKNFDSFIADNEFVLVEFYAPWCGHCKALAPEYAKAATTLEEEKLNVKLGKVDATVEESLASQFEVRGYPTIKFFRKEKP-DGPAD----YNGGRQAADIVNWLKKKTGPPAKELKEKDEVKSFVEKDEVVVIGFFKDQESTGALAFKKAAAGIDDIPFAITSEDHVFKEYKMDKD-GIVLLKKFDEGRNDFEGEF-EEEAIVKHVRENQLPLVVEFTQESAQKIFGG-EVKNHILLFLKKEGGEDT-IEKFRGAAGDFKGKVLFIYLDTDNEENGRITEFFGLKDDEIPAVRLIQLA-EDMSKYKPESLDLETATIKKFVQDFLDGKLKPHLMSEDMPDDWDAKPVKVLVGKNFKEVAMDKSKAVFVEFYAPWCGHCKQLAPIWDELGEKYKDSKDIVVAKMDATANEIEEVKVQSFPTLKYFPKDSEEAVDYNGERTLDAFIKFLESGGTEGAGVPEDEEE----EEED--EGDDE--DLPRDEL A_0039_258 MKFSSCLVLTLLVFVSAEDVKQEEGVYVLTTKNFDSFIADNEFVLVEFYAPWCGHCKALAPEYAKAATTLEEEKLNVKLGKVDATVEESLASQFEVRGYPTIKFFRKEKP-DGPAD----YNGGRQAADIVNWLKKKTGPPAKELKEKDEVKSFVEKDEVVVIGFFKDQESTGALAFKKAAAGIDDIPFAITSEDHVFKEYKMDKD-GIVLLKKFDEGRNDFEGEF-EEEAIVKHVRENQLPLVVEFTQESAQKIFGG-EVKNHILLFLKKEGGEDT-IEKFRGAAGDFKGKVLFIYLDTDNEENGRITEFFGLKDDEIPAVRLIQLA-EDMSKYKPESLDLETATIKKFVQDFLDGKLKPHLMSEDMPDDWDAKPVKVLVGKNFKEVAMDKSKAVFVEFYAPWCGHCKQLAPIWDELGEKYKDSKDIVVAKMDATANEIEEVKVQSFPTLKYFPKDSEEAVDYNGERTLDAFIKFLESGGTEGAGVPEDEEE----EEED--EGDDE--DLPRDEL A_0055_282 MKFSSCLVLTLLVFVSAEDVKQEEGVYVLTTKNFDSFIADNEFVLVEFYAPWCGHCKALAPEYAKAATTLEEEKLNVKLGKVDATVEESLASQFEVRGYPTIKFFRKEKP-DGPAD----YNGGRQAADIVNWLKKKTGPPAKELKEKDEVKSFVEKDEVVVIGFFKDQESTGALAFKKAAAGIDDIPFAITSEDHVFKEYKMDKD-GIVLLKKFDEGRNDFEGEF-EEEAIVKHVRENQLPLVVEFTQESAQKIFGG-EVKNHILLFLKKEGGEDT-IEKFRGAAGDFKGKVLFIYLDTDNEENGRITEFFGLKDDEIPAVRLIQLA-EDMSKYKPESLDLETATIKKFVQDFLDGKLKPHLMSEDMPDDWDAKPVKVLVGKNFKEVAMDKSKAVFVEFYAPWCGHCKQLAPIWDELGEKYKDSKDIVVAKMDATANEIEEVKVQSFPTLKYFPKDSEEAVDYNGERTLDAFIKFLESGGTEGAGVPEDEEE----EEED--EGDDE--DLPRDEL A_0855_199 MKFSSCLVLTLLVFVSAEDVKQEEGVYVLTTKNFDSFIADNEFVLVEFYAPWCGHCKALAPEYAKAATTLEEEKLNVKLGKVDATVEESLASQFEVRGYPTIKFFRKEKP-DGPAD----YNGGRQAADIVNWLKKKTGPPAKELKEKDEVKSFVEKDEVVVIGFFKDQESTGALAFKKAAAGIDDIPFAITSEDHVFKEYKMDKD-GIVLLKKFDEGRNDFEGEF-EEEAIVKHVRENQLPLVVEFTQESAQKIFGG-EVKNHILLFLKKEGGEDT-IEKFRGAAGDFKGKVLFIYLDTDNEENGRITEFFGLKDDEIPAVRLIQLA-EDMSKYKPESLDLETATIKKFVQDFLDGKLKPHLMSEDMPDDWDAKPVKVLVGKNFKEVAMDKSKAVFVEFYAPWCGHCKQLAPIWDELGEKYKDSKDIVVAKMDATANEIEEVKVQSFPTLKYFPKDSEEAVDYNGERTLDAFIKFLESGGTEGAGVPEDEEE----EEED--EGDDE--DLPRDEL A_0885_279 MKFSSCLVLTLLVFVSAEDVKQEEGVYVLTTKNFDSFIADNEFVLVEFYAPWCGHCKALAPEYAKAATTLEEEKLNVKLGKVDATVEESLASQFEVRGYPTIKFFRKEKP-DGPAD----YNGGRQAADIVNWLKKKTGPPAKELKEKDEVKSFVEKDEVVVIGFFKDQESTGALAFKKAAAGIDDIPFAITSEDHVFKEYKMDKD-GIVLLKKFDEGRNDFEGEF-EEEAIVKHVRENQLPLVVEFTQESAQKIFGG-EVKNHILLFLKKEGGEDT-IEKFRGAAGDFKGKVLFIYLDTDNEENGRITEFFGLKDDEIPAVRLIQLA-EDMSKYKPESLDLETATIKKFVQDFLDGKLKPHLMSEDMPDDWDAKPVKVLVGKNFKEVAMDKSKAVFVEFYAPWCGHCKQLAPIWDELGEKYKDSKDIVVAKMDATANEIEEVKVQSFPTLKYFPKDSEEAVDYNGERTLDAFIKFLESGGMEGAGVPEDEEE----EEED--EGDDE--DLPRDEL V_1258_220 MKFSSCLVLTLLVFVSAEDVKQEEGVHVLTTKNFDSFIADNEFVLVEFYAPWCGHCKALAPEYAKAATTLEEEKLNVKLGKVDATVEESLASKFEVRGYPTIKFFRKEKP-DGPAD----YNGGRQAADIVNWLKKKTGPPAKELKEKDEVKSFVEKDEVVVIGFFKDQESTGALAFKKAAAGIDDIPFAITSEDHVFKEYKMDKD-GIVLLKKFDEGRNDFEGEF-EEEAIVKHVRENQLPLVVEFTQESAQKIFGG-EVKNHILLFLKKEGGEDT-IEKFRGAAGDFKGKVLFIYLDTDNEENGRITEFFGLKDDEIPAVRLIQLA-EDMSKYKPESLDLETATIKKFVQDFLDGKLKPHLMSEDVPDDWDAKPVKVLVGKNFKEVAMDKSKAVFVEFYAPWCGHCKQLAPIWDELGEKYKDSKDIVVAKMDATANEIEEVKVQSFPTLKYFPKDSEEAVDYNGERTLDAFIKFLESGGTEGAGVPEDEEE----EEED--EGDDE--DLPRDEL V_CG13_261 MKFSSCLVLTLLVFVSAEDVKQEEGVHVLTTKNFDSFIADNEFVLVEFYAPWCGHCKALAPEYAKAATTLEEEKLNVKLGKVDATVEESLASKFEVRGYPTIKFFRKEKP-DGPAD----YNGGRQAADIVNWLKKKTGPPAKELKEKDEVKSFVEKDEVVVIGFFKDQESTGALAFKKAAAGIDDIPFAITSEDHVFKEYKMDKD-GIVLLKKFDEGRNDFEGEF-EEEAIVKHVRENQLPLVVEFTQESAQKIFGG-EVKNHILLFLKKEGGEDT-IEKFRGAAGDFKGKVLFIYLDTDNEENGRITEFFGLKDDEIPAVRLIQLA-EDMSKYKPESLDLETATIKKFVQDFLDGKLKPHLMSEDVPDDWDAKPVKVLVGKNFKEVAMDKSKAVFVEFYAPWCGHCKQLAPIWDELGEKYKDSKDIVVAKMDATANEIEEVKVQSFPTLKYFPKDSEEAVDYNGERTLDAFIKFLESGGTEGAGVPEDEEE----EEED--EGDDE--DLPRDEL V_1302_228 MKFSSCLVLTLLVFVSAEDVKQEEGVHVLTTKNFDSFIADNEFVLVEFYAPWCGHCKALAPEYAKAATTLEEEKLNVKLGKVDATVEESLASKFEVRGYPTIKFFRKEKP-DGPAD----YNGGRQAADIVNWLKKKTGPPAKELKEKDEVKSFVEKDEVVVIGFFKDQESTGALAFKKAAAGIDDIPFAITSEDHVFKEYKMDKD-GIVLLKKFDEGRNDFEGEF-EEEAIVKHVRENQLPLVVEFTQESAQKIFGG-EVKNHILLFLKKEGGEDT-IEKFRGAAGDFKGKVLFIYLDTDNEENGRITEFFGLKDDEIPAVRLIQLA-EDMSKYKPESLDLETATIKKFVQDFLDGKLKPHLMSEDVPDDWDAKPVKVLVGKNFKEVAMDKSKAVFVEFYAPWCGHCKQLAPIWDELGEKYKDSKDIVVAKMDATANEIEEVKVQSFPTLKYFPKDSEEAVDYNGERTLDAFIKFLESGGTEGAGVPEDEEE----EEED--EGDDE--DLPRDEL V_1278_121 MKFSSCLVLTLLVFVSAEDVKQEEGVHVLTTKNFDSFIADNEFVLVEFYAPWCGHCKALAPEYAKAATTLEEEKLNVKLGKVDATVEESLASKFEVRGYPTIKFFRKEKP-DGPAD----YNGGRQAADIVNWLKKKTGPPAKELKEKDEVKSFVEKDEVVVIGFFKDQESTGALAFKKAAAGIDDIPFAITSEDHVFKEYKMDKD-GIVLLKKFDEGRNDFEGEF-EEEAIVKHVRENQLPLVVEFTQESAQKIFGG-EVKNHILLFLKKEGGEDT-IEKFRGAAGDFKGKVLFIYLDTDNEENGRITEFFGLKDDEIPAVRLIQLA-EDMSKYKPESLDLETATIKKFVQDFLDGKLKPHLMSEDVPDDWDAKPVKVLVGKNFKEVAMDKSKAVFVEFYAPWCGHCKQLAPIWDELGEKYKDSKDIVVAKMDATANEIEEVKVQSFPTLKYFPKDSEEAVDYNGERTLDAFIKFLESGGTEGAGVPEDEEE----EEED--EGDDE--DLPRDEL A_1387_130 MKFSSCLVLTLLVFVSAEDVKQEEGVYVLTTKNFDSFIADNEFVLVEFYAPWCGHCKALAPEYAKAATTLEEEKLNVKLGKVDATVEESLASQFEVRGYPTIKFFRKEKP-DGPAD----YNGGRQAADIVNWLKKKTGPPAKELKEKDEVKSFVEKDEVVVIGFFKDQESTGALAFKKAAAGIDDIPFAITSEDHVFKEYKMDKD-GIVLLKKFDEGRNDFEGEF-EEEAIVKHVRENQLPLVVEFTQESAQKIFGG-EVKNHILLFLKKEGGEDT-IEKFRGAAGDFKGKVLFIYLDTDNEENGRITEFFGLKDDEIPAVRLIQLA-EDMSKYKPESLDLETATIKKFVQDFLDGKLKPHLMSEDMPDDWDAKPVKVLVGKNFKEVAMDKSKAVFVEFYAPWCGHCKQLAPIWDELGEKYKDSKDIVVAKMDATANEIEEVKVQSFPTLKYFPKDSEEAVDYNGERTLDAFIKFLESGGTEGAGVPEDEEE----EEED--EGDDE--DLPRDEL A_0025_178 MKFSSCLVLTLLVFVSAEDVKQEEGVYVLTTKNFDSFIADNEFVLVEFYAPWCGHCKALAPEYAKAATTLEEEKLNVKLGKVDATVEESLASQFEVRGYPTIKFFRKEKP-DGPAD----YNGGRQAADIVNWLKKKTGPPAKELKEKDEVKSFVEKDEVVVIGFFKDQESTGALAFKKAAAGIDDIPFAITSEDHVFKEYKMDKD-GIVLLKKFDEGRNDFEGEF-EEEAIVKHVRENQLPLVVEFTQESAQKIFGG-EVKNHILLFLKKEGGEDT-IEKFRGAAGDFKGKVLFIYLDTDNEENGRITEFFGLKDDEIPAVRLIQLA-EDMSKYKPESLDLETATIKKFVQDFLDGKLKPHLMSEDMPDDWDAKPVKVLVGKNFKEVAMDKSKAVFVEFYAPWCGHCKQLAPIWDELGEKYKDSKDIVVAKMDATANEIEEVKVQSFPTLKYFPKDSEEAVDYNGERTLDAFIKFLESGGTEGAGVPEDEEE----EEED--EGDDE--DLPRDEL A_0520_082 MKFSSCLVLTLLVFVSAEDVKQEEGVYVLTTKNFDSFIADNEFVLVEFYAPWCGHCKALAPEYAKAATTLEEEKLNVKLGKVDATVEESLASQFEVRGYPTIKFFRKEKP-DGPAD----YNGGRQAADIVNWLKKKTGPPAKELKEKDEVKSFVEKDEVVVIGFFKDQESTGALAFKKAAAGIDDIPFAITSEDHVFKEYKMDKD-GIVLLKKFDEGRNDFEGEF-EEEAIVKHVRENQLPLVVEFTQESAQKIFGG-EVKNHILLFLKKEGGEDT-IEKFRGAAGDFKGKVLFIYLDTDNEENGRITEFFGLKDDEIPAVRLIQLA-EDMSKYKPESLDLETATIKKFVQDFLDGKLKPHLMSEDMPDDWDAKPVKVLVGKNFKEVAMDKSKAVFVEFYAPWCGHCKQLAPIWDELGEKYKDSKDIVVAKMDATANEIEEVKVQSFPTLKYFPKDSEEAVDYNGERTLDAFIKFLESGGTEGAGVPEDEEE----EEED-EGDDDE--DLPRDEL A_0048_312 MKFSSCLVLTLLVFVSAEDVKQEEGVYVLTTKNFDSFIADNEFVLVEFYAPWCGHCKALAPEYAKAATTLEEEKLNVKLGKVDATVEESLASQFEVRGYPTIKFFRKEKP-DGPAD----YNGGRQAADIVNWLKKKTGPPAKELKEKDEVKSFVEKDEVVVIGFFKDQESTGALAFKKAAAGIDDIPFAITSEDHVFKEYKMDKD-GIVLLKKFDEGRNDFEGEF-EEEAIVKHVRENQLPLVVEFTQESAQKIFGG-EVKNHILLFLKKEGGEDT-IEKFRGAAGDFKGKVLFIYLDTDNEENGRITEFFGLKDDEIPAVRLIQLA-EDMSKYKPESLDLETATIKKFVQDFLDGKLKPHLMSEDMPDDWDAKPVKVLVGKNFKEVAMDKSKAVFVEFYAPWCGHCKQLAPIWDELGEKYKDSKDIVVAKMDATANEIEEVKVQSFPTLKYFPKDSEEAVDYNGERTLDAFIKFLESGGTEGAGVPEDEEE----EEED-EGDDDE--DLPRDEL K_0010_217 MKFSSCLVLTLLVFVSAEDVKQEEGVYVLTTKNFDSFIADNEFVLVEFYAPWCGHCKALAPEYAKAATSLEEEKLSIKLGKVDATVEESLASKFEVRGYPTIKFFRKEKP-DSPAD----YNGGRQAVDIVNWLKKKTGPPAKELKEKDEVKSFVEKDEVVVIGFFKDQESTGALAFKKAAAGIDDIPFAITSEDHVFKEYKMDKD-GVVLLKKFDEGRNDFEGEF-EEEAIVKHVRENQLPLVVEFTQESAQKIFGG-EVKNHILLFLKKEDGEDT-IEKFRGAAEDFKGKVLFIYLDTDNEENGRITEFFGLKDDEIPAVRLIQLA-EDMSKYKPESSDLETATIKKFVQDFLDGKLKPHLMSEDVPDDWDAKPVKVLVGKNFKEVVMDKSKAVFVEFYAPWCGHCKQLAPIWDELGEKYKDSKDIVVAKMDATANEIEEVKVQSFPTLKYFPKDSEEAVDYNGERTLDAFVKFLESGGKEGAGVPEDEEE------ED-EEGDDE--DLPRDEL ermineusAXL95400 MKFSSCLVLTLLVFVSAEDVKQEEGVYVLTTKNFDAFIAENEFVLVEFYAPWCGHCKALAPEYAKAATTLEDEKLNIKLGKVDATVEESLASKFEVRGYPTIKFFRKEKP-DSPAD----YNGGRQALDIVNWLKKKTGPPAKELKEKDEVKSFVEKDEVVVIGFFKDQESTGALAFKKAAAGVDDIPFAITSEDHVFKEYKMDKD-GIVLLKKFDEGRNDFEGEF-EEEAIVKHVRENQLPLVVEFTQESAQKIFGG-EVKNHILLFLKKEGGEDT-IEKFRGAAEDFKGKVLFIYLDTDNEENGRITEFFGLKDDEIPAVRLIQLA-EDMSKYKPESSDLETATIKKFVQDFLDGKLKPHLMSEDVPDDWDAKPVKVLVGKNFKEVAMDKSKAVFVEFYAPWCGHCKQLAPIWDELGEKFKDNKDIVVAKMDATANEIEEVKVQSFPTLKYFPKDSEEAVDYNGERTLDAFVKFLESGGKEGAGVPEDEEE----EEED-EEGDDE--DLQRDEL striatusAOZ19956 MKFSSCLVLTLLVFVSAEDVKQEEGVHVLTTKNFDSFIADNEFVLVEFYAPWCGHCKALAPEYAKAASTLEEEKLNIKLGKVDATVEESLASKFEVRGYPTIKFFRKEKP-DSPAD----YNGGRQAVDIVNWLKKKTGPPAKELKEKDEVKSFVEKDEVVVIGFFKDQESTGALAFKKAAASIDDIPFAITSEDHVFKEYKMDKD-GIVLLKKFDEGRNDFEGEF-EEEAIVKHVRENQLPLVVEFTQESAQKIFGG-EVKNHILLFLKKEGGEDT-IEKFRGAAEGFKGKVLFIYLDTDNEENGRITEFFGLKDDEIPAVRLIQLA-EDMSKYKPESSDLETATIKKFVQDFLDGKLKPHLMSEDVPDDWDAKPVKVLVGKNFNEVAMDKSKAVFVEFYAPWCGHCKQLAPIWDELGEKYKDSKDIIVAKMDATANEIEEVKVQSFPTLKYFPKDSEEAVDYNGERTLDAFVKFLESGGTEGAGVPEDEEE----EEED-DEGDDE--DLPRDEL betulinusADZ76593 MKFSSCLVLTLLVFVSAEDVIKEEGVYVLTTKNFDSFIADNEFVLVEFYAPWCGHCKALAPEYAKAATTLEEEKLQIKLGKVDATVEESLASKFEVRGYPTIKFFSKEKP-GSPAD----YNGGRQAVDIVNWLKKKTGPPAKELKEKDEVKSFVEKDEVVVIGFFKDQESAGALAFKKAAAGIDDIPFAITSEDHVFKEYKMDKD-GIVLLKKFDEGRNDFEGEL-EEEAIVKHVRENQLPLVVEFTQESAQKIFGG-EVKNHILLFLKKEGGEDT-IEKFRGAAEDFKGKVLFIYLDTDDEENGRITEFFGLKDDEIPAVRLIQLA-EDMSKYRPESSDLETATIKKFVQDFLDGKLKPHLMSEDVPDDWDAKPVKVLVGKNFKEVAMDKSKAVFVEFYAPWCGHCKQLAPIWDELGEKYKDSKDIVVAKMDATANEIEEVKVQSFPTLKYFPKDSEEAVDYNGERTLDAFIKFLESGGTEGAGVPEDEEE----EEED-EEGDDE--DLPRDEL quercinusAOZ19955 MKFSSCLVLTLLVFVSAEDVIQEEGVYVLTTKNFDSFVADNEFVLVEFYAPWCGHCKALAPEYAKAATTLEAEKLQIKLAKVDATVEGTLATRFEVRGYPTIKFFRKEKP-GSPAD----YNGGRQAVDIVNWLKKKTGPPAKELKEKDEVKSFVEKDEVVVIGFFKDQESTGALAFKKAAAGIDDIPFAITSEDHVFKEYKMDKD-GIVLLKKFDEGRNDFDGEF-EEEAIVKHVRENQLPLVVEFTQESAQKIFGG-EVKNHILLFLKKDGGEDT-IEKFRGAAEDFKGKVLFIYLDTDNEENGRITEFFGLKDDEIPAVRLIQLA-EDMSKYKPESSDLETATIKKFVQDFLDGKLKPHLMSEDVPDDWDAKPVKVLVGKNFKEVAMDKSKAVFVEFYAPWCGHCKQLAPIWDELGEKYKDSKDIVVAKMDATANEIEEVKVQSFPTLKYFPKDSEEAVDYNGERTLDAFIKFLESGGTEGAGVPEDEEE----EEED-EEGEDE--DLPRDEL ebraeusAOZ19952 MKFSSCLVLTLLVFVSAEEVKREEDVYVLTTKNFDSFIADNEFVLVEFYAPWCGHCKALAPEYAKAATALEEQNLNVKLGKVDATVEDSLAAKFEVRGYPTIKFFRKDKP-KSPAD----YTGGRQSDDIINWLKKKTGPPAKELKEKDDVKSFVEKDEVVVIGFFKDQESTGALAFKKAAASIDDIPFAITSEDHVFKEYKMDKD-GVVLLKKFDEGRNDFEGEF-EEEAIVKHVRENQLPLVVEFTQESAQKIFGG-EVKNHILLFLKKEGGEDT-IEKFRGAAEDFKGKVLFIYLDTDNEENGRITEFFGLKDDEIPAVRLIQLA-EDMSKYKPESSDLETATIKKFVQDFLDGKLKPHLMSEDVPDDWDAKPVKILVGKNFKEVAMDKSKAVFVEFYAPWCGHCKQLAPIWDELGEKYKDSKDIVVAKMDATANEIEEVKVQSFPTLKYFPKDSEEAVDYNGERTLDAFVKFLESGGTEGAGVPEDEEE----EEED-EEGDDE--DLPRDEL marmoreusABF48564 MKFSSCLVLTLLVFVSADDIKQEEGVYVLTKKNFDSFITENEFVLVEFYAPWCGHCKALAPEYAKAATTLEEEKLNIKLGKVDATVEEDLASKFEVRGYPTIKFFHKEKP-NKPAD----YNGGRQAVDIVNWLKKKTGPPAKELKEKEEVKSFVEKDEVVVIGFFKDQESTGALAFKKAAAGIDDIPFAITSEDHVFKEYKMDKD-GIVLLKKFDEGRNDFDGEF-EEEAIVKHVRENQLPLVVEFTQESAQKIFGG-EVKNHILLFLKKEGGEDT-IEKFRGAAEDFKGKVLFIYLDTDNEENGRITEFFGLKDDEIPAVRLIQLA-EDMSKYKPESSDLETATIKKFVQDFLDGKLKPHLMSEDVPDDWDAKPVKVLVGKNFKEVAMDKSKAVFVEFYAPWCGHCKQLAPIWDELGEKYKDSKDIVVAKMDATANEIEEVKVQSFPTLKYFPKDSEEGVDYNGERTLDAFVKFLESDGTEGAGVPEDEEE----EEED-EEGDDE--DLPRDEL eburneusADZ76591 MKFSSCLVLTLLVFVSAEDVKQEEDVYVLTTKNFDSFIADNEFVLVEFYAPWCGHCKALAPEYAKAAASLEEEKLQIKLAKVDATVEDTLATRFEVRGYPTIKFFRKEKP-DSPTD----YNGGRQALDIVNWLKKKTGPPAKELKEKDEAKSFVEKDEVVVIGFFKDQESAGALAFKKAAAGIDDIPFAITSEDHVFKEYKMDKD-GIVLLKKFDEGRNDFEGEF-EEEAIVKHVRENQLPLVVEFTQESAQKIFGG-EVKNHILLFLKKEGGEDT-IEKFRGAAEDFRGKVLFIYLDTDNEENGRITEFFGLKDDEIPAVRLIQLA-EDMSKYKPESSDLETATIKKFVQDFLDGKLKPHLMSEDVPDDWDAKPVKVLVGKNFKEVAMDKSKAVFVEFYAPWCGHCKQLAPIWDELGEKFKDSKDIVVAKMDATANEIEEVKVQSFPTLKYFPKDSEEAVDYNGERTLDAFVKFLESGGTEGAGVPEDEEE----EEED-EEGDNE--DLPRDEL lividusAOZ19953 MKFSSCLVLTLLVFVSAEDVDKEEGVYVLTTKNFDSFVADNEFVLVEFYAPWCGHCKALAPEYAKAATTLEGEELQIKLAKVDATVEVTLATKFEVRGYPTIKFFRKEKP-GSAAD----YTGGRQAGDIVQWLKKKTGPPAKELKEKDDVKSFVEKDEVVVIGFFKDQESTGALAFKKAAAGIDDIPFAITSEDHVFKEYKMDKD-GIVLLKKFDEGRNDFEGEF-EEEAIVKHVRENQLPLVVEFTQESAQKIFGG-EVKXHILLFLKKDGGEDT-IEKFRGAAEDFKGKVLFIYLDTDNEENGRITEFFGLKDDEIPAVRLIQLA-EDMSKYKPESSDLETATIKKFVQDFMDGKLKPHLMSEDVPDDWDAKPVKVLVGKNFKEVAMDKSKAVFVEFYAPWCGHCKQLAPIWDELGEKYKDSKDIVVAKMDSTANEIEEVKVQSFPTLKYFPKDSEEAVDYNGERTLDAFIKFLESGGTEGAGVPEDEEE----EEED-EEGDDE--DLPRDEL vexillumAOZ19960 MKFSSCLVLTLLVFVSAEEVKREEGVYVLTTKNFDSFIADNEFVLVEFYAPWCGHCKALAPEYAKAAATLEEEKSDIKLAKVDATEEANLATKFEVRGYPTIKFFRKENA-GSPSD----YGGGRQAVDIVNWLKKKTGPPAAELKEKDDVKSFVEKDEVVVIGFFKDQESAGALAFKKAAAGIDDIPFGITSEDHVFKEYKMDKD-GIVLLKKFDEGRSDFEGEF-EEEAIIKHVRENQLPLVVEFTQESAQKIFGG-EVKNHILLFLKKEGGEDT-IEKFRGAAEGFKGKVLFIYLDTDNEENGRITEFFGLKDDEIPAVRLIQLA-EDMSKYKPESSDLETATIKKFVQDFLDGKLKPHLMSEDVPDDWDAKPVKVLVGKNFKDVAMDKAKAVFVEFYAPWCGHCKQLAPIWDELGEKYKDSKDIVVAKMDATANEIEEVKVQSFPTLKYFPKDSEEAVDYNGERTLDAFVKFLESGGTEGAGVPEDEEE----EEED-EEGDDE--DLPRDEL milesAOZ19954 MKFSSCLVLTLLVFVSAEEVKREESVYVLTTKNFDSFIADNEFVLVEFYAPWCGHCKALAPEYAKAAATLEEEKLDIKLAKVDATEEANLATKFEVRGYPTIKFFRKENA-GSPSD----YGGGRQAVDIVNWLKKKTGPPAAELKEKDDVKSFVEKDEVVVIGFFKDQESAGALAFKKAAAGIDDIPFGITSEDHVFKEYKMDKD-GIVLLKKFDEGRSDFEGEF-EEEAIIKHVRENQLPLVVEFTQESAQKIFGG-EVKNHILLFLKKEGGEDT-IEKFRGAAEGFKGKVLFIYLDTDNEENGRITEFFGLKDDEIPAVRLIQLA-EDMSKYKPESSDLETATIKKFVQDFLDGKLKPHLMSEDVPDDWDAKPVKVLVGKNFKDVAMDKAKAVFVEFYAPWCGHCKQLAPIWDELGEKYKDSKDIVVAKMDATANEIEEVKVQSFPTLKYFPKDSEEAVDYNGERTLDAFVKFLESGGTEGAGVPEDEEE----EEED-EEGDDE--DLPRDEL textileAMM62647 MKFSSCLVLTLLVFVSAEDVKQEEGVYVLTEKNFDGFISDNEFVLVEFYAPWCGHCKALAPEYAKAATTLEEEKSNIKLGKVDATVEVNLATKFEVRGYPTIKFFHKEMPAGSPAD----YSGGRQAPDIVGWLKKKTGPPAKELKAKDEVKTFVEKDEVVVIGFFKDQESTGALAFKKAAAGIDDIPLAITSEDHVFKEYKMDKD-GIVLLKKFDEGRNDFEGNLEEEEAIVKHVRENQLPLVVEFTQESAQKIFGG-EVKNHILLFLKKEGGEDT-IEKFRGAAEDFKGKVLFIYLDTDNEENGRITEFFGLKDDEIPAVRLIQLA-EDMSKYKPESSDLETATIKKFVQDFLDGKLKPHLMSEDVPGDWDAKPVKVLVGKNFKEVAMDKSKAVFVEFYAPWCGHCKQLAPIWDELGEKYKDSKDIVVAKMDATANEIEEVKVQSFPTLKYFPKDSDEAVDYNGERTLDAFVKFLESGGTEGAGVQEDEEE----EEED-EEGDDE--DLPRDEL imperialisADZ76592 MKFSSCLVLTLLVLVSAEDVKEEEGVHVLTNNNFDSFINEYESVLVEFYAPWCGHCKALAPEYAKAAQKLKEENENIKLAKVDATVEDKLAAKFEVRGYPTIKFFRKEKS-NSPVD----YSAGRQAEDIVNWLKKKTGPPAKELKDKDAAKTFVEKDEVVVIGFFKDQESEGALAFKKAAAGIDDIPFSITSDDAVFKEYKMDRD-GVVLLKKFDEGRNDFEGEF-EAEAITKHVRDNQLPLVVEFTQESAQKIFGG-EVKNHILLFVKKEGGEDT-IEKFRGAAGDFKGKVLFIYLDTDNEDNGRITEFFGLKDDEIPAVRLIQLA-EDMSKFKPESSDLETATIKKFVQDFLDDKLKRHLMSEDVPDDWDAKPVKVLVGKNFKDVVMDGSKAVFVEFYAPWCGHCKQLAPIWDELGEKYKDSNDIVITKMDATANEVEDVKVQSFPTLKYFPKDGGKVVDYNGERTLEAFVKFLDSDGKEGAGAPEGEEE----EEDDEEEGDED--DLPRDEL geographusAMM62646 MKFSSCLVLTLLVFVSAEDVKQEEGVYVLTAKNFDSFIADNEFVLVEFYAPWCGHCKALAPEYAKAATTLEEEKLNIKLGKVDATVEESLAAKFEVRGYPTIKFFRKEKP-DGPAD----YSGGRQAADIVSWLKKKTGPPAKELKEKDEVKSFVEKDEVVVIGFFKDQESTGALAFKKAAAGIDDIPFAITSEDHVFKEYKMDRD-GIVLLKKFDEGRNDFDGEF-EEEAIVKHVRENQLPLVVEFTQESAQKIFGG-EVKNHILLFLKKEGGEDT-IEKFRGAAEDFKGKVLFIYLDTDNEENGRITEFFGLKDDEIPAVRLIQLA-EDMSKYKPESSDLETATIKKFVQDFLDGKLKPHLMSEDVPDDWDAKPVKVLVGKNFKEVAMDKSKAVFVEFYAPWCGHCKQLAPIWDELGEKYKDSKDIVVAKMDATANEIEEVKVQSFPTLKYFPRDSEEAVDYNGERTLDAFVKFLESGGTEGAGVPEDEEE----EEED-EEGDDE--DLPRDEL bullatusAMM62649 MKFSSCLVLTLVVFVSAEDVKQEEGVYVLTTKNFDSFIADNEFVLVEFYAPWCGHCKALAPEYAKAATSLEEEKSNIKLGKVDATVEEKLASTFEVRGYPTIKFFRKEKP-DGPAD----YTGGRQAKDIVDWLKKKTGPPAKELKEKDDVKSFVEKDEVVVIGFFKDQESTGALAFKKAAAGIDDIPFAITSEDHVFKEYKMDKD-GIVLLKKFDEGRNDFDGEF-EEEAIVKHVRENQLPLVVEFTQESAQKIFGG-EVKNHILLFLKKEGGEDT-IEKFRGAAEDFKGKVLFIYLDTDNEENGRITEFFGLKDDEIPAVRLIQLA-EDMSKYKPESSDLETATIKKFVQDFLDGKLKPHLMTEDVPDDWDAKPVKVLVGKNFKEVAMDKSKAVFVEFYAPWCGHCKQLAPIWDELGEKYKDSKDIVVAKMDATANEIEEVKVQSFPTLKYFPKDSEEAVDYNGERTLDAFIKFLESGGTEGAGVPEEEEE----EEED-EEGDDE--DLPRDEL magusQFQ61180 MKFSSCLVLTLLVFVSAEDVIQEESVYVLTTKNFDSFMADNEFVLVEFYAPWCGHCKALAPEYAKAAASLEEEKSNIKLGKVDATKEDDLASKFEVRGYPTIKFFRRKEP-DGPASYHGDYSGGRQAGDIVTWLKKKTGPPAKELKEKDEVKSFVEKDEVVVIGFFKDQESTGALAFKKAAAGIDDIPFAITSEDHVFKEYKMDKD-GIVLLKKFDEGRNDFEGEF-EEEAIVKHVRENQLPLVVEFTQESAQKIFGG-EVKNHILLFLKKEGGEDT-IEKFRGAAEDFKGKVLFIYLDTDNEENGRITEFFGLKDDEIPAVRLIQLA-EDMSKYKPESSDLETATIKKFVQDFLDGKLKPHLMSEDVPDDWNAKPVKVLVGKNFKEVAMDKSKAVFVEFYAPWCGHCKQLAPIWDELGEKYKDSKDIVVAKMDATANEIEEVKVQSFPTLKYFPKDSEEAVDYNGERTLDAFVKFLESGGTEGAGVPEDEEE----EEED-EEGDDE--DLPRDEL aplysiaXP_005104403 MLRFALFALAVIVKVSAGDIEEDEGVLVLTNSNFEGAIADNEFVLVEFYAPWCGHCKALAPEYAKAAGALKSDGSNVKLGKVDATVESELAEKFQVRGYPTLKFFKN----GNPIE----YSGGRQSADIVNWLKKKTGPPAIDLSDKDAASSFREKEEVVVIGFFKDQESDDAKEFLKVASAMDDLPFGITSNSEVFADNKVEKD-GIVLFKKFDEGRNDFDGEV-KEADIRTFISSNRLPLVIEFTQESAQKVFGG-EVKNHILMFLKKEGSEDV-IKGYGEAAAEFKGKILFIYLDTDNEDNGRIMEFFGLKAEEVPAVRLITLA-EDMTKYRPTADGVDPATIKQFAQDFLDGKLKPHLMSEEIPEDWDAKPVKVLVGKNFKEVALNQDKAVFVEFYAPWCGHCKQLAPVWDELAEAYEDNDKIVVAKMDSTANEVEEVKVQSFPTLKYFPAGSDKIIDYNGERTLAGFKKFLDSDGKDGAGVAEEEEEDEEEEEDD-EEGDDE---APRDEL A_0039_293 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAEKLLTG-DIQSHLMLLVKKEEAKDT-LDTFKAAAGKFKGKVQFIYLDTAKEESEHIMEFFDLKAADTPAMRLIQLGEEDLVKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKELAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIKSFPTLKYFPKGSDEIIEYDGEKTLEELTKFVESGGKQEPPKKEEEEK----EEEDDDKKKDE--------L A_0039_295 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAEKLLTG-DIQSHLMLLVKKEEAKDT-LDTFKAAAGKFKGKVQFIYLDTAKEESEHIMEFFDLKAADTPAMRLIQLGEEDLVKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKELAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIKSFPTLKYFPKGSDKIIEYDGERTLEELTKFVESGGKQEPPKKEEEEE----EEEDDDKKKDE--------L A_0039_294 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAQKIFKG-DIQSHLMLFVKKEGAKDT-LDTFKAAAGEFKGKVLFIYLDIAKEENEHIMGFFGLKAADAPAMRLIQLGE-DLAKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKELAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIKSFPTLKYFPKGSDKIIEYDGERTLEELTKFVESGGKQEPPKKEEEEE----EEEDDDKKKDE--------L A_0039_296 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAQKIFKG-DIQSHLMLFVKKEGAKDT-LDTFKAAAGEFKGKVLFIYLDIAKEENEHIMGFFGLKAADAPAMRLIQLGE-DLAKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKELAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIKSFPTLKYFPKGSDEIIEYDGEKTLEELTKFVESGGKQEPPKKEEEEK----EEEDDDKKKDE--------L V_1278_159 ----------------------------------------------------------------------------------------------------------S----GEPKDYTGGRQTSDIVNWLKKKTGPPAKDVKTSEEAKTFIDSDEVIIMGFFKDQEGKAAAAFKKIAAEIEDVAFGITSEDSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFILETAEKLFTG-DVKSHLMLFVKKEEAKDT-LDTFKAAAGKFKGKVQFIYLDTAKEESEHVMGFFGLEAADTPAMRLIQLSEEDQVKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKKLAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIKSFPTLKYFPKGSDEIIEYDGEKTLEELTKFVESGGKQEPPKKEEEEE----EEEDDDKKKDE--------L A_0855_227 MKFATVFSLTLLAFVACEEVEQEENVYVLKATNFDNFIRENEFVLVEFYAPWCGACKNLAPVYSEVAGKLMDEGSNIKLAKVDVTVEEDLAEKFDVEGYPTIKFFSS----GEPKDYTGGRQTSDFINWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIASEIVDVAFGITSEDSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAEKLLTG-DVKSHLMLLVKKEEAKDT-LDTFKAAAGKFKGKVQFIYLDTAKEESEHVMEFFGLKAADTPAMRLIQLGEEDLVKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKELAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIESFPTLKYFPKGSDEIIEYDGEKTLEELTKFVESGGKQEPPKKEEEEK----EEEDDDKKKDE--------L A_0855_229 MKFATVFSLTLLAFVACEEVEQEENVYVLKATNFDNFIRENEFVLVEFYAPWCGACKNLAPVYSEVAGKLMDEGSNIKLAKVDVTVEEDLAEKFDVEGYPTIKFFSS----GEPKDYTGGRQTSDFINWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIASEIVDVAFGITSEDSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAEKLLTG-DVKSHLMLLVKKEEAKDT-LDTFKAAAGKFKGKVQFIYLDTAKEESEHVMEFFGLKAADTPAMRLIQLGEEDLVKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKELAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIESFPTLKYFPKGSDKIIEYEGERTLEELTKFVESGGKQEPPKKEEEEE----EEEDDDKKKDE--------L A_0875_217 MKFATVFSLTLLAFVACEEVEQEENVYVLKATNFDNFIRENEFVLVEFYAPWCGACKNLAPVYSEVAGKLMDEGSNIKLAKVDVTVEEDLAEKFDVEGYPTIKFFSS----GEPKDYTGGRQTSDFINWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIASEIEDVAFGITSEDSVFKKHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAEKLLTG-DIQSHLMLLVKKEEAKDT-LDTFKAAAGKFKGKVQFIYLDTAKEESEHIMEFFDLKAADTPAMRLIQLGEEDLVKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKKLAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIKSFPTLKYFPKGSDKIIEYDGERTLEELTKFVESGGKQEPPKKEEEEE----EEEDDDKKKDE--------L A_0875_219 MKFATVFSLTLLAFVACEEVEQEENVYVLKATNFDNFIRENEFVLVEFYAPWCGACKNLAPVYSEVAGKLMDEGSNIKLAKVDVTVEEDLAEKFDVEGYPTIKFFSS----GEPKDYTGGRQTSDFINWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIASEIEDVAFGITSEDSVFKKHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAEKLLTG-DIQSHLMLLVKKEEAKDT-LDTFKAAAGKFKGKVQFIYLDTAKEESEHIMEFFDLKAADTPAMRLIQLGEEDLVKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKKLAPIWDQLGEKFKDSKDIIIAKMDSTANEFEEVKIESFPTLKYFPKGSDEIIEYDGEKTLEELTKFVESGGKQEPPKKEEEEE----EEEDDDKKKDE--------L A_0055_321 MKFATVFSLTLLAFVACEEVEQEENVYVLKATNFDNFIRENEFVLVEFYAPWCGACKNLAPVYSEVAGKLMDEGSNIKLAKVDVTVEKDLAEKFDVEGYPTIKFFSS----GEPKDYTGGRQTSDFINWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIASEIEDVAFGITSEDSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAEKLLTG-DVKSHLLLFVKKEEAKDT-LDTFKAAAGKFKGKVQFIYLDTAKEESEHVMEFFGLKAADTPAMRLIQLGEEDLVKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKELAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIKSFPTLKYFPKGGDEIIEYDGEKTLEELTKFVESGGKQEPPKKEEEEE----EEEDDDKKKDE--------L A_0885_284 MKFATVFSLTLLAFVACEEVEQEENVYVLKATNFDNFIRENEFVLVEFYAPWCGACMNLAPVYSEVAGKLMDEGSNIKLAKVDVTVEKDLAEKFDVEGYPTIKFFSS----GEPKDYTGGRQTSDFVNWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIASEIVDVAFGITSEDSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAEKLLTG-DVKSHLILFVKKEEAKDT-LDTFKAAAGKFKGKVQFIYLDTAKEESEHIMGFFSLKAADTPAMRLIQLGEEDLVKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKKLAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIESFPTLKYFPKGSDEIIEYDGEKTLEELTKFVESGGKQEPPKKEEEEK----EEEDDDKKKDE--------L A_0885_286 MKFATVFSLTLLAFVACEEVEQEENVYVLKATNFDNFIRENEFVLVEFYAPWCGACMNLAPVYSEVAGKLMDEGSNIKLAKVDVTVEKDLAEKFDVEGYPTIKFFSS----GEPKDYTGGRQTSDFVNWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIASEIVDVAFGITSEDSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAEKLLTG-DVKSHLILFVKKEEAKDT-LDTFKAAAGKFKGKVQFIYLDTAKEESEHIMGFFSLKAADTPAMRLIQLGEEDLVKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKKLAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIESFPTLKYFPKGSDEIIEYDGERTLEELTKFVESGGKQEPPKKEEEEE----EEEDDDKKKDE--------L V_1278_156 MKFATVFSLTLLAFVACEEVEQEEKVYVLKATNFDNFIKENEFVLVEFYAPWCGACKNLAPVYSEVAGKLMDEGSNIKLAKVDVTVEKDLAEKFDVEGYPTIKFFNS----GEPKDYTGGRQTSDIVNWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIAAEIEDVAFGITSEDSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFILETAEKLFTG-DVKSHLMLFVKKEEAKDT-LDTFKAAAGKFKGKVQFIYLDTAKEESEHVMGFFGLEAADTPAMRLIQLSEEDQVKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKKLAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIKSFPTLKYFPKGSDEIIEYDGEKTLEELTKFVESGGKQEPPKKEEEEE----EEEDDDKKKDE--------L V_CG13_304 MKFATVFSLTLLAFVACEEVEQEEKVYVLKATNFDNFIKENEFVLVEFYAPWCGACKNLAPVYSEVAGKLMDEGSNIKLAKVDVTVEKDLAEKFDVKGYPTIKFFSS----GEPKDYTGGRQTSDFINWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIASEIEDVAFGITSEDSIFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFILETAEKLFTG-DVKSHLMLFVKKEEAKDT-LDTFKAAAGKFKGKVQFIYLDTAKEESEHVMGFFGLEAADTPAMRLIQLSEEDQVKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKKLAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIKSFPTLKYFPKGSDEIIEYDGERTLEELTKFVESGGKQEPPKKEEEEE----EEEDDDKKKDE--------L V_1258_241 MKFATVFSLTLLAFVACEEVEQEEKVYVLKATNFDNFIKENEFVLVEFYAPWCGACKNLAPVYSEVAGKLMDEGSNIKLAKVDVTVEKDLAEKFNVEGYPTIKFFSS----GEPKDYTGGRQTSDFINWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIASEIENVAFGITSEDSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFILETAEKLFTG-DVKSHLMLFVKKEEAKDT-LDTFKAAAGEFKGKVLFIYLDTAKEESEHVMGFFGLKAADTPAMRLIQLSEEDQVKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKKLAPIWDQLGEKFKDSKDIIIAKMDTTANELEEVKIESFPTLKYFPKGSDEIIEYDGEKTLEELTKFVESGGKQEPPKKEEEEE----EEEDDDKKKDE--------L V_1258_242 MKFATVFSLTLLAFVACEEVEQEEKVYVLKATNFDNFIKENEFVLVEFYAPWCGACKNLAPVYSEVAGKLMDEGSNIKLAKVDVTVEKDLAEKFNVEGYPTIKFFSS----GEPKDYTGGRQTSDFINWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIASEIENVAFGITSEDSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFILETAEKLFTG-DVKSHLMLFVKKEEAKDT-LDTFKAAAGEFKGKVLFIYLDTAKEESEHVMGFFGLKAADTPAMRLIQLSEEDQVKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKKLAPIWDQLGEKFKDSKDIIIAKMDTTANELEEVKIESFPTLKYFPKGSDEIIEYDGEKTLEELTKFVESGGKQEPPKKEEEEK----EEEDDDKKKDE--------L V_1302_278 MKFATVFSLTLLAFVACEEVEQEEKVYVLKATNFDNFIKENEFVLVEFYAPWCGACKNLAPVYSEVAGKLMDEGSNIKLAKVDVTVEKDLAEKFNVEGYPTIKFFSS----GEPKDYTGGRQTSDFINWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIASEIENVAFGITSEDSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFILETAEKLFTG-DVKSHLMLFVKKEEAKDT-LDTFKAAAGKFKGKVQFIYLDTAKEESEHVMGFFGLKAADTPAMRLIQLSEEDQVKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKKLAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIESFPTLKYFPKGSDEIIEYDGERTLEELTKFVESGGKQEPPKKEEEEE----EEEDDDKKKDE--------L A_0055_320 MKFATVFSLTLLAFVACEEVEQEENVYVLKATNFDNFIRENEFVLVEFYAPWCGACKNLAPVYSEVAGKLMDEGSNIKLAKVDVTVEKDLAEKFDVEGYPTIKFFSS----GEPKDYTGGRQTSDFINWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIASEIEDVAFGITSEDSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAQKIFKG-DIQSHLMLFVKKEGAKDT-LDTFKAAAGKFKGKVLFIYLDIAKEENEHIMGFFGLKAADAPAMRLIQLGE-DLAKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKELAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIKSFPTLKYFPKGSDKIIEYDGERTLEELTKFVESGGKQEPPKKEEEEE----EEEDDDKKKDE--------L A_0875_218 MKFATVFSLTLLAFVACEEVEQEENVYVLKATNFDNFIRENEFVLVEFYAPWCGACKNLAPVYSEVAGKLMDEGSNIKLAKVDVTVEEDLAEKFDVEGYPTIKFFSS----GEPKDYTGGRQTSDFINWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIASEIEDVAFGITSEDSVFKKHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAQKIFKG-DIQSHLMLFVKKEGAKDT-LDTFKAAAGEFKGKVLFIYLDIAKEENEHIMGFFGLKAADAPAMRLIQLGE-DLAKYKPESDSLDKSAMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKKLAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIKSFPTLKYFPKGSDKIIEYDGERTLEELTKFVESGGKQEPPKKEEEEE----KEEDDDKKKDE--------L V_1302_277 MKFATVFSLTLLAFVACEEVEQEEKVYVLKATNFDNFIKENEFVLVEFYAPWCGACKNLAPVYSEVAGKLMDEGSNIKLAKVDVTVEKDLAEKFNVEGYPTIKFFSS----GEPKDYTGGRQTSDFINWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIAAEIEDVAFGITSEDSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAQKIFTG-DIQSHLMLFVKKEEAKDT-LDTFKAAAGKFKGKVQFIYLDTAKEENEHIMGFFGLKAADAPAMRLIQLGE-DLAKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKELAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIESFPTLKYFPKGSDEIIEYDGEKTLEELTKFVESGGKQEPLKKEEEEK----EEEDDDKKKDE--------L A_0885_283 MKFATVFSLTLLAFVACEEVEQEEKVYVLKTKNFDNFIKENEFVLVEFYAPWCGHCKQLAPEYSKAAGKLMDEGSNIKLAKVDATVEKDLAEKFEVKGFPTIKFFIS----GEPVDYTGGRQTSDIVNWLKKKTGPPAKDVKTSEEAKTFIDGDEVIVMGFFKDQEGKAAAAFKKIASEIEDVAFGITSEDSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAQKIFKG-DIQSHLMLFVKKEGAKDT-LDTFKAAAGEFKGKVLFIYLDIAKEENEHIMGFFGLKAADAPAMRLIQLGE-DLAKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKKLAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIESFPTLKYFPKGSDEIIEYDGERTLEELTKFVESGGKQEPPKKEEEEE----EEEDDDKKKDE--------L A_0885_285 MKFATVFSLTLLAFVACEEVEQEEKVYVLKTKNFDNFIKENEFVLVEFYAPWCGHCKQLAPEYSKAAGKLMDEGSNIKLAKVDATVEKDLAEKFEVKGFPTIKFFIS----GEPVDYTGGRQTSDIVNWLKKKTGPPAKDVKTSEEAKTFIDGDEVIVMGFFKDQEGKAAAAFKKIASEIEDVAFGITSEDSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAQKIFKG-DIQSHLMLFVKKEGAKDT-LDTFKAAAGEFKGKVLFIYLDIAKEENEHIMGFFGLKAADAPAMRLIQLGE-DLAKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKKLAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIESFPTLKYFPKGSDEIIEYDGEKTLEELTKFVESGGKQEPPKKEEEEK----EEEDDDKKKDE--------L A_0855_228 MKFATVFSLTLLAFVACEEVEQEEKVYVLKTKNFDNFIKENEFVLVEFYAPWCGHCKQLAPEYSKAAGKLMDEGSNIKLAKVDATVEKDLAEKFEVKGFPTIKFFIS----GEPVDYTGGRQTSDIVNWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIASEIEDVAFGITSEDSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAQKIFKG-DIQSHLMLFVKKEGAKDT-LDTFKAAAGEFKGKVLFIYLDIAKEENEHIMGFFGLKAADAPAMRLIQLGE-DLAKYKPESDSLDKSAMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKELAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIESFPTLKYFPKGSDEIIEYDGEKTLEELTKFVESGGKQEPPKKEEEEK----EEEDDDKKKDE--------L A_0055_322 MKFATVFSLTLLAFVACEEVEQEEKVYVLKTKNFDNFIKENEFVLVEFYAPWCGHCKQLAPEYSKAAGKLMDEGSNVKLAKVDATVEKDLAEKFEVKGFPTIKFFIS----GEPVDYTGGRQTSDIVNWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIASEIEDVAFGITSEDSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAQKIFKG-DIQSHLMLFVKKEGAKDT-LDTFKAAAGKFKGKVLFIYLDIAKEENEHIMGFFGLKAADAPAMRLIQLGE-DLAKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKELAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIKSFPTLKYFPKGGDEIIEYDGEKTLEELTKFVESGGKQEPPKKEEEEE----EEEDDDKKKDE--------L A_0875_216 MKFATVFSLTLLAFVACEEVEQEEKVYVLKTKNFDNFIKENEFVLVEFYAPWCGHCKQLAPEYSKAAGKLMDEGSNVKLAKVDATVEKDLAEKFEVKGFPTIKFFIS----GEPVDYTGGRQTSDIVNWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIASEIEDVAFGITSEDSVFKKHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAQKIFKG-DIQSHLMLFVKKEGAKDT-LDTFKAAAGEFKGKVLFIYLDIAKEENEHIMGFFGLKAADAPAMRLIQLGE-DLAKYKPESDSLDKSAMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKKLAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIKSFPTLKYFPKGSDKIIEYDGERTLEELTKFVESGGKQEPPKKEEEEE----EEEDDDKKKDE--------L A_0855_230 MKFATVFSLTLLAFVACEEVEQEEKVYVLKTKNFDNFIKENEFVLVEFYAPWCGHCKQLAPEYSKAAGKLMDEGSNIKLAKVDATVEKDLAEKFEVKGFPTIKFFIS----GEPVDYTGGRQTSDIVNWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIASEIEDVAFGITSEDSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAQKIFKG-DIQSHLMLFVKKEGAKDT-LDTFKAAAGEFKGKVLFIYLDIAKEENEHIMGFFGLKAADAPAMRLIQLGE-DLAKYKPESDSLDKSAMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKELAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIESFPTLKYFPKGSDKIIEYEGERTLEELTKFVESGGKQEPPKKEEEEE----EEEDDDKKKDE--------L V_CG13_305 MKFATVFSLTLLAFVACEEVEQEEKVYVLKTKNFDNFIKENEFVLVEFYAPWCGHCKQLAPEYSKAAGKLIDEGSNIKLAKVDATVEKDLAGKFEVKGFPTIKFFIS----GEPKDYTGGRQTSDIVNWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIASEIEDVAFGITSEDSIFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAQKIFTG-DIQSHLMLFVKKEEAKDT-LDTFKAAAGEFKGKVLFIYLDTAKEENEHIMGFFGLKAADAPAMRLIQLGE-DLAKYKPASDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKKLAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIKSFPTLKYFPKGSDEIIEYDGERTLEELTKFVESGGKQEPPKKEEEEE----EEEDDDKKKDE--------L V_CG13_306 MKFATVFSLTLLAFVACEEVEQEEKVYVLKTKNFDNFIKENEFVLVEFYAPWCGHCKQLAPEYSKAAGKLIDEGSNIKLAKVDATVEKDLAGKFEVKGFPTIKFFIS----GEPKDYTGGRQTSDIVNWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIASEIEDVAFGITSEDSIFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAQKIFTG-DIQSHLMLFVKKEEAKDT-LDTFKAAAGEFKGKVLFIYLDTAKEENEHIMGFFGLKAADAPAMRLIQLGE-DLAKYKPASDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKKLAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIKSFPTLKYFPKGSDEIIEYDGEKTLEELTKFVESGGKQEPPKKEEEEE----EEEDDDKKKDE--------L V_1278_157 MKFATVFSLTLLAFVACEEVEQEEKVYVLKTKNFDNFIKENEFVLVEFYAPWCGHCKQLAPEYSKAAGKLIDEGSNIKLAKVDATVEKDLAGKFEVKGFPTIKFFIS----GEPKDYTGGRQTSDIVNWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIAAEIEDVAFGITSEDSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAQKIFTG-DIQSHLMLFVKKEEAKDT-LDTFKAAAGEFKGKVLFIYLDTAKEENEHIMGFFGLKAADAPAMRLIQLGE-DLAKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKKLAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIKSFPTLKYFPKGSDEIIEYDGERTLEELTKFVESGGKQEPPKKEEEEE----EEEDDDKKKDE--------L V_1278_158 MKFATVFSLTLLAFVACEEVEQEEKVYVLKTKNFDNFIKENEFVLVEFYAPWCGHCKQLAPEYSKAAGKLIDEGSNIKLAKVDATVEKDLAGKFEVKGFPTIKFFIS----GEPKDYTGGRQTSDIVNWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIAAEIEDVAFGITSEDSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAQKIFTG-DIQSHLMLFVKKEEAKDT-LDTFKAAAGEFKGKVLFIYLDTAKEENEHIMGFFGLKAADAPAMRLIQLGE-DLAKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKKLAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIKSFPTLKYFPKGSDEIIEYDGEKTLEELTKFVESGGKQEPPKKEEEEE----EEEDDDKKKDE--------L V_1302_280 MKFATVFSLTLLAFVACEEVEQEEKVYVLKTKNFDNFIKENEFVLVEFYAPWCGHCKQLAPEYSKAAGKLIDEGSNIKLAKVDATVEKDLAGKFEVKGFPTIKFFIS----GEPKDYTGGRQTSDIVNWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIAAEIEDVAFGITSEDSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAQKIFTG-DIQSHLMLFVKKEEAKDT-LDTFKAAAGKFKGKVQFIYLDTAKEENEHIMGFFGLKAADAPAMRLIQLGE-DLAKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKKLAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIESFPTLKYFPKGSDEIIEYDGERTLEELTKFVESGGKQEPPKKEEEEE----EEEDDDKKKDE--------L V_1258_239 MKFATVFSLTLLAFVACEEVEQEEKVYVLKTKNFDNFIKENEFVLVEFYAPWCGHCKQLAPEYSKAAGKLIDEGSNIKLAKVDATVEKDLAGKFEVKGFPTIKFFIS----GEPKDYTGGRQTSDIVNWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIAAEIEDVAFGITSEDSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAQKIFTG-DIQSHLMLFVKKEEAKDT-LDTFKAAAGEFKGKVLFIYLDTAKEENEHIMGFFGLKAADAPAMRLIQLGE-DLAKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKKLAPIWDQLGEKFKDSKDIIIAKMDTTANELEEVKIESFPTLKYFPKGSDEIIEYDGEKTLEELTKFVESGGKQEPPKKEEEEE----EEEDDDKKKDE--------L V_1258_240 MKFATVFSLTLLAFVACEEVEQEEKVYVLKTKNFDNFIKENEFVLVEFYAPWCGHCKQLAPEYSKAAGKLIDEGSNIKLAKVDATVEKDLAGKFEVKGFPTIKFFIS----GEPKDYTGGRQTSDIVNWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIAAEIEDVAFGITSEDSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAQKIFTG-DIQSHLMLFVKKEEAKDT-LDTFKAAAGEFKGKVLFIYLDTAKEENEHIMGFFGLKAADAPAMRLIQLGE-DLAKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKKLAPIWDQLGEKFKDSKDIIIAKMDTTANELEEVKIESFPTLKYFPKGSDEIIEYDGEKTLEELTKFVESGGKQEPPKKEEEEK----EEEDDDKKKDE--------L A_0055_319 MKFATVFSLTLLAFVACEEVEQEEKVYVLKTKNFDNFIKENEFVLVEFYAPWCGHCKQLAPEYSKAAGKLMDEGSNVKLAKVDATVEKDLAEKFEVKGFPTIKFFIS----GEPVDYTGGRQTSDIVNWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIASEIEDVAFGITSEDSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAEKLLTG-DVKSHLLLFVKKEEAKDT-LDTFKAAAGKFKGKVQFIYLDTAKEESEHVMEFFGLKAADTPAMRLIQLGEEDLVKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKELAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIKSFPTLKYFPKGSDKIIEYDGERTLEELTKFVESGGKQEPPKKEEEEE----EEEDDDKKKDE--------L V_1302_279 MKFATVFSLTLLAFVACEEVEQEEKVYVLKTKNFDNFIKENEFVLVEFYAPWCGHCKQLAPEYSKAAGKLIDEGSNIKLAKVDATVEKDLAGKFEVKGFPTIKFFIS----GEPKDYTGGRQTSDIVNWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIASEIENVAFGITSEDSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFILETAEKLFTG-DVKSHLMLFVKKEEAKDT-LDTFKAAAGKFKGKVQFIYLDTAKEESEHVMGFFGLKAADTPAMRLIQLSEEDQVKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKELAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIESFPTLKYFPKGSDEIIEYDGEKTLEELTKFVESGGKQEPLKKEEEEK----EEEDDDKKKDE--------L A_0239_398 MKFATVFSLTLLAFVACEEVEQEEKVYVLKTKNFDNFIKENEFVLVEFYAPWCGHCKQLAPEYSKAAGKLMDEGSNIKLAKVDATVEKDLAEKFEVKGFPTIKFFIS----GEPVDYTGGRQTSDIVNWLKKKTGPPAKDVKTSQEAKTFIDSNEVIVMGFFKDQEGKAAAAFKKIASEIEDVAFGITSENSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAQKIFTG-DIQSHLMLFVKKEGAKDA-LDTFKAAAGEFKGKVLFIYLDTAKEENEHIMGFFGLKAADAPAMRLIQLG-EDLAKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKKLAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIKSFPTLKYFPKGSDEIIEYDGERTLEELTKFVKSGGKQEPPKKEEEEE----EEDD-DKKKDE--------L A_0031_358 MKFATVFSLTLLAFVACEKVEQEEKVYVLKTKNFDNFIKENEFVLVEFYAPWCGHCKQLAPEYSKAAGKLMDEGSNIKLAKVDATVEKDLAEKFEVKGFPTIKFFIS----GEPVDYTGGRQTSDIVNWLKKKTGPPAKDVKTSQEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIASEIEDVAFGITSENSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAQKIFTG-DIQSHLMLFVKKEGAKDA-LDTFKAAAGEFKGKVLFIYLDTAKEENEHIMGFFGLKAADAPAMRLIQLG-EDLAKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKKLAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIKSFPTLKYFPKGSDEIIEYDGERTLEELTKFVKSGGKQEPPKKEEEEE----EEDD-DKKKDE--------L A_0239_400 MKFATVFSLTLLAFVACEEVEQEEKVYVLKTKNFDNFIKENEFVLVEFYAPWCGHCKQLAPEYSKAAGKLMDEGSNIKLAKVDATVEKDLAEKFEVKGFPTIKFFIS----GEPVDYTGGRQTSDIVNWLKKKTGPPAKDVKTSQEAKTFIDSNEVIVMGFFKDQEGKAAAAFKKIASEIEDVAFGITSENSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAQKIFTG-DIQSHLMLFVKKEGAKDA-LDTFKAAAGEFKGKVLFIYLDTAKEENEHIMGFFGLKAADAPAMRLIQLG-EDLAKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGNCKELAPIWDQLGEKFKDSKDIIIAKMDSTTNELEEVKIKSFPTLKYFPKGSDEIIEYDGERTLEELTKFVKSGGKQEPPKKEEEEK----EE-D-DKKKDE--------L A_0025_297 MKFATVFSLTLLAFVACEKVEQEEKVYVLKATNFDNFIKENEFVLVEFYAPWCGACKNLAPVYSEVAGKLMDEGSNIKLAKVDVTVEKDLAEKFDVEGYPTIKFFSS----GEPKDYTGGRQTSDFINWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIASEIEDVAFGITSEDSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAQKLFTG-DVKSHLILFVKKEEAKDT-LDTFKAAAGKFKGKVQFIYLDTAKEESEHIMEFFSLKAADTPAMRLIQLGEEDLVKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKELAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIKSFPTLKYFPKGSDEIIEYDGEKTLEELTKFVESGGKQEPPKKEEEEK----EEDD-DKKKDE--------L A_0025_296 MKFATVFSLTLLAFVACEKVEQEEKVYVLKATNFDNFIKENEFVLVEFYAPWCGACKNLAPVYSEVAGKLMDEGSNIKLAKVDVTVEKDLAEKFDVEGYPTIKFFSS----GEPKDYTGGRQTSDFINWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIASEIEDVAFGITSEDSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAQKLFTG-DVKSHLILFVKKEEAKDT-LDTFKAAAGKFKGKVQFIYLDTAKEESEHIMEFFSLKAADTPAMRLIQLGEEDLVKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKELAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIKSFPTLKYFPKGSDEIIEYDGERTLEELTKFVESGGKQEPPKKEEEEE----EEDD-DKKKVE--------L A_0048_260 MKFATVFSLTLLAFVACEEVEQEENVYVLKATNFDNFIRENEFVLVEFYAPWCGACKNLAPVYSEVAGKLMDEGSNIKLAKVDVTVEKDLAEKFDVEGYPTIKFFSS----GEPKDYTGGRQTSDFINWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIASEIEDVAFGITSEDSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAKKLLTG-DVKSHLMLLVKKEEAKDT-LDTFKAAAGKFKGKVQFIYLDTAKEESEHIMEFFSLKAADTPAMRLIQLGEEDLVKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCRHCKELAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIESFPTLKYFPKGSDEIIEYDGEKTLEELTKFVESGGKQEPPKKEEEEK----EEDD-DKKKDE--------L A_0520_283 MKFATVFSLTLLAFVACEEVEQEENVYVLKATNFDNFIRENEFVLVEFYAPWCGACKNLAPVYSEVAGKLMDEGSNIKLAKVDVTVEKDLAEKFDVEGYPTIKFFSS----GEPKDYTGGRQTSDFINWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIASEIEDVAFGITSEDSVFKKHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAKKLLTG-DVKSHLMLLVKKEEAKDT-LDTFKAAAGKFKGKVQFIYLDTAKEESEHIMEFFSLKAADTPAMRLIQLGEEDLVKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKELAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIESFPTLKYFPKGSDEIIEYDGEKTLEELTKFVESGGKQEPPKKEEEEK----EEDD-DKKKDE--------L A_0520_282 MKFATVFSLTLLAFVACEEVEQEENVYVLKATNFDNFIRENEFVLVEFYAPWCGACKNLAPVYSEVAGKLMDEGSNIKLAKVDVTVEKDLAEKFDVEGYPTIKFFSS----GEPKDYTGGRQTSDFINWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIASEIEDVAFGITSEDSVFKKHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAKKLLTG-DVKSHLMLLVKKEEAKDT-LDTFKAAAGKFKGKVQFIYLDTAKEESEHIMEFFSLKAADTPAMRLIQLGEEDLVKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKELAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIESFPTLKYFPKGSDEIIEYDGERTLEELTKFVESGGKQEPPKKEEEEE----EEDD-DKKKDE--------L A_1387_308 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAQKIFKG-DIQSHLMLFVKKEGAKDT-LDTFKAAAGEFKGKVLFIYLDIAKEENEHIMGFFGLKAADAPAMRLIQLG-EDLAKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKKLAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIESFPTLKYFPKGSDEIIEYDGERTLEELTKFVESGGKQEPPKKEEEEE----EEDD-DKKKDE--------L A_1387_309 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAQKIFKG-DIQSHLMLFVKKEGAKDT-LDTFKAAAGEFKGKVLFIYLDIAKEENEHIMGFFGLKAADAPAMRLIQLG-EDLAKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKKLAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIESFPTLKYFPKGSDEIIEYDGEKTLEELTKFVESGGKQEPPKKEEEEK----EEDD-DKKKDE--------L A_0025_293 MKFATVFSLTLLAFVACEKVEQEEKVYVLKTKNFDNFIKENEFVLVEFYAPWCGHCKQLAPEYSKAAGKLMDEGSNIKLAKVDATVEKDLAEKFEVKGFPTIKFFIS----GEPVDYTGGRQTSDIVSWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIASEIEDVAFGITSEDSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAQKIFKG-DIQSHLMLFVKKEGAKDT-LDTFKAAAGEFKGKVLFIYLDIAKEENEHIMGFFGLKAADAPAMRLIQLG-EDLAKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKELAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIKSFPTLKYFPKGSDEIIEYDGEKTLEELTKFVESGGKQEPPKKEEEEK----EEDD-DKKKDE--------L A_0025_294 MKFATVFSLTLLAFVACEKVEQEEKVYVLKATNFDNFIKENEFVLVEFYAPWCGACKNLAPVYSEVAGKLMDEGSNIKLAKVDVTVEKDLAEKFDVEGYPTIKFFSS----GEPKDYTGGRQTSDFINWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIASEIEDVAFGITSEDSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAQKIFKG-DIQSHLMLFVKKEGAKDT-LDTFKAAAGEFKGKVLFIYLDIAKEENEHIMGFFGLKAADAPAMRLIQLG-EDLAKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKELAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIKSFPTLKYFPKGSDEIIEYDGEKTLEELTKFVESGGKQEPPKKEEEEK----EEDD-DKKKDE--------L A_0025_292 MKFATVFSLTLLAFVACEKVEQEEKVYVLKTKNFDNFIKENEFVLVEFYAPWCGHCKQLAPEYSKAAGKLMDEGSNIKLAKVDATVEKDLAEKFEVKGFPTIKFFIS----GEPVDYTGGRQTSDIVSWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIASEIEDVAFGITSEDSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAQKLFTG-DVKSHLILFVKKEEAKDT-LDTFKAAAGKFKGKVQFIYLDTAKEESEHIMEFFSLKAADTPAMRLIQLGEEDLVKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKELAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIKSFPTLKYFPKGSDEIIEYDGEKTLEELTKFVESGGKQEPPKKEEEEK----EEDD-DKKKDE--------L A_0025_295 MKFATVFSLTLLAFVACEKVEQEEKVYVLKTKNFDNFIKENEFVLVEFYAPWCGHCKQLAPEYSKAAGKLMDEGSNIKLAKVDATVEKDLAEKFEVKGFPTIKFFIS----GEPVDYTGGRQTSDIVSWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIASEIEDVAFGITSEDSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAQKLFTG-DVKSHLILFVKKEEAKDT-LDTFKAAAGKFKGKVQFIYLDTAKEESEHIMEFFSLKAADTPAMRLIQLGEEDLVKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKELAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIKSFPTLKYFPKGSDEIIEYDGERTLEELTKFVESGGKQEPPKKEEEEE----EEDD-DKKKVE--------L A_0048_262 MKFATVFSLTLLAFVACEEVEQEEKVYVLKTKNFDNFIKENEFVLVEFYAPWCGHCKQLAPEYSKAAGKLMDEGSNIKLAKVDATVEKDLAEKFQVKGFPTIKFFIS----GEPVDYTGGRQTSDIVNWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIASEIEDVAFGITSEDSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAKKLLTG-DVKSHLMLLVKKEEAKDT-LDTFKAAAGKFKGKVQFIYLDTAKEESEHIMEFFSLKAADTPAMRLIQLGEEDLVKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCRHCKELAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIESFPTLKYFPKGSDEIIEYDGERTLEELTKFVESGGKQEPQKKEEEEE----EEDD-DKKKDE--------L A_0520_284 MKFATVFSLTLLAFVACEEVEQEEKVYVLKTKNFDNFIKENEFVLVEFYAPWCGHCKQLAPEYSKAAGKLMDEGSNIKLAKVDATVEKDLAEKFEVKGFPTIKFFIS----GEPVDYTGGRQTSDIVNWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIASEIEDVAFGITSEDSVFKKHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAQKIFKG-DIQSHLMLFVKKEGAKDT-LDIFKAAAGEFKGKVLFIYLDTAKEENEHIMGFFGLKAADAPAMRLIQLG-EDLAKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKELAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIESFPTLKYFPKGSDEIIEYDGERTLEELTKFVESGGKQEPPKKEEEEE----EEDD-DKKKDE--------L A_0048_259 MKFATVFSLTLLAFVACEEVEQEEKVYVLKTKNFDNFIKENEFVLVEFYAPWCGHCKQLAPEYSKAAGKLMDEGSNIKLAKVDATVEKDLAEKFQVKGFPTIKFFIS----GEPVDYTGGRQTSDIVNWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIASEIEDVAFGITSEDSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAQKIFKG-DIQSHLMLFVKKEGAKDT-LDIFKAAAGEFKGKVLFIYLDTAKEENEHIMGFFGLKAADAPAMRLIQLG-EDLAKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKKLAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIESFPTLKYFPKGSDEIIEYDGERTLEELTKFVESGGKQEPQKKEEEEE----EEDD-DKKKDE--------L A_0048_261 MKFATVFSLTLLAFVACEEVEQEENVYVLKATNFDNFIRENEFVLVEFYAPWCGACKNLAPVYSEVAGKLMDEGSNIKLAKVDVTVEKDLAEKFDVEGYPTIKFFSS----GEPKDYTGGRQTSDFINWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIASEIEDVAFGITSEDSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAQKIFKG-DIQSHLMLFVKKEGAKDT-LDIFKAAAGEFKGKVLFIYLDTAKEENEHIMGFFGLKAADAPAMRLIQLG-EDLAKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKKLAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIESFPTLKYFPKGSDEIIEYDGERTLEELTKFVESGGKQEPQKKEEEEE----EEDD-DKKKDE--------L A_0239_399 MKFATVFSLTLLAFVACEKVEQEEKVYVLKATNFDNFIKENEFVLVEFYAPWCGACKNLAPVYSEVAGKLMDEGSNIKLAKVDVTVEKDLAEKFDVEGYPTIKFFSS----GEPKDYTGGRQTSDFINWLKKKTGPPAKDVKTSQEAKTFIDSNEVIVMGFFKDQEGKAAAAFKKIASEIEDVAFGITSENSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAQKIFTG-DIQSHLMLFVKKEGAKDA-LDTFKAAAGEFKGKVLFIYLDTAKEENEHIMGFFGLKAADAPAMRLIQLG-EDLAKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKKLAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIKSFPTLKYFPKGSDEIIEYDGERTLEELTKFVKSGGKQEPPKKEEEE------------------------- A_0031_357 MKFATVFSLTLLAFVACEKVEQEEKVYVLKATNFDNFIKENEFVLVEFYAPWCGACKNLAPVYSEVAGKLMDEGSNIKLAKVDVTVEKDLAEKFDVEGYPTIKFFSS----GEPKDYTGGRQTSNFINWLKKKTGPPAKDVKTSQEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIASEIEDVAFGITSENSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAQKIFTG-DIQSHLMLFVKKEGAKDA-LDTFKAAAGEFKGKVLFIYLDTAKEENEHIMGFFGLKAADAPAMRLIQLG-EDLAKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKKLAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVKIKSFPTLKYFPKGSDEIIEYDGERTLEELTKFVKSGGKQEPPKKEEEEE----EEDD-DKKKDE--------L A_0239_401 MKFATVFSLTLLAFVACEKVEQEEKVYVLKATNFDNFIKENEFVLVEFYAPWCGACKNLAPVYSEVAGKLMDEGSNIKLAKVDVTVEKDLAEKFDVEGYPTIKFFSS----GEPKDYTGGRQTSDFINWLKKKTGPPAKDVKTSQEAKTFIDSNEVIVMGFFKDQEGKAAAAFKKIASEIEDVAFGITSENSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAEKLLTG-DVKSHLMLFVKKEEAKDT-LDTFKAAAGKFKGKVQFIYLDTAKEESEHIMGFFGLKAADTPAMRLIQLGEEDVVKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGNCKELAPIWDQLGEKFKDSKDIIIAKMDSTTNELEEVKIKSFPTLKYFPKGSDEIIEYDGERTLEELTKFVKSGGKQEPPKKEEEEK----EE-D-DKKKDE--------L A_0031_355 MKFATVFSLTLLAFVACEKVEQEEKVYVLKATNFDNFIKENEFVLVEFYAPWCGACKNLAPVYSEVAGKLMDEGSNIKLAKVDVTVEKDLAEKFDVEGYPTIKFFSS----GEPKDYTGGRQTSNFINWLKKKTGPPAKDVKTSQEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIASEIEDVAFGITSENSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAEKLLTG-DVKSHLMLFVKKEEAKDT-LDTFKAAAGKFKGKVQFIYLDTAKEESEHIMGFFGLKAADTPAMRLIQLGEEDLVKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGNCKELAPIWDQLGEKFKDSKDIIIAKMDSTTNELEEVKIKSFPTLKYFPKGSDEIIEYDGERTLEELTKFVKSGGKQEPPKKEEEEK----EE-D-DKKKDE--------L A_0239_402 MKFATVFSLTLLAFVACEEVEQEEKVYVLKTKNFDNFIKENEFVLVEFYAPWCGHCKQLAPEYSKAAGKLMDEGSNIKLAKVDATVEKDLAEKFEVKGFPTIKFFIS----GEPVDYTGGRQTSDIVNWLKKKTGPPAKDVKTSQEAKTFIDSNEVIVMGFFKDQEGKAAAAFKKIASEIEDVAFGITSENSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAEKLLTG-DVKSHLMLFVKKEEAKDT-LDTFKAAAGKFKGKVQFIYLDTAKEESEHIMGFFGLKAADTPAMRLIQLGEEDVVKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGNCKELAPIWDQLGEKFKDSKDIIIAKMDSTTNELEEVKIKSFPTLKYFPKGSDEIIEYDGERTLEELTKFVKSGGKQEPPKKEEEEK----EE-D-DKKKDE--------L A_0031_356 MKFATVFSLTLLAFVACEKVEQEEKVYVLKTKNFDNFIKENEFVLVEFYAPWCGHCKQLAPEYSKAAGKLMDEGSNIKLAKVDATVEKDLAEKFEVKGFPTIKFFIS----GEPVDYTGGRQTSDIVNWLKKKTGPPAKDVKTSQEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIASEIEDVAFGITSENSVFKEHKMKKD-GIVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAEKLLTG-DVKSHLMLFVKKEEAKDT-LDTFKAAAGKFKGKVQFIYLDTAKEESEHIMGFFGLKAADTPAMRLIQLGEEDLVKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGNCKELAPIWDQLGEKFKDSKDIIIAKMDSTTNELEEVKIKSFPTLKYFPKGSDEIIEYDGERTLEELTKFVKSGGKQEPPKKEEEEK----EE-D-DKKKDE--------L K_0010_390 MKFATVFSLTLLAFVACEEVEQEEKVYVLKTTNFDNFIKENEFVLVEFYAPWCGACKNLAPVYSEVAGKLMDEGSNIKLAKVDVTVEKDLAEKFDVKGYPTIKFFSS----GEPTDYTGGRQTSNFIKWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKDAAAFKKIAAEIRDVTFGITSEDSVFKEHKMKRD-GVVLFKKFDEGRSDFSGDF-EEAAMSKFVKDNRLPLINEFTRETAEKLFTG-DVQSLLMLFIKKEGAKDT-LDTFKAAASEFKGKVLFIYLDTAKEENEHIMGFFGLKAADAPAMRLIQLG-EDLAKYKPESDTLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKKLAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVQIKSFPTLKYFPKGSDEIIEYDGERTLEELTKFVESGGKQEPPEKEEEEK----EE-DDDKKKDE--------L K_0010_391 MKFATVFSLTLLAFVACEEVEQEEKVYVLKTTNFDNFIKENEFVLVEFYAPWCGHCKNLAPVYSEVAGKLMDEGSNIKLAKVDATVEKDLAGKFEVKGFPTIKFFSS----GEPTDYTGGRQTSDIINWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKGAAAFKKIAAEIEDVAFGITSEDSVFKEHKMKKD-GVVLFKKFDEGRSDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAQKIFSG-DVQSHLMLFIKKEGAKDT-LDTFKAAASEFKGKVLFIYLDTAKEENEHIMGFFGLKAADAPAMRLIQLG-EDLAKYKPESDTLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKKLAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVQIKSFPTLKYFPKGSDEIIEYDGERTLEELTKFVESGGKQEPPEKEEEEK----EE-DDDKKKDE--------L ermineusAXL95393 MKFATVFSLTLLAFVACEEVEQEEKVYVLKATNFDNFIKENEFVLVEFYAPWCGHCKNLAPVYSEAAGKLMDEGSNIKLAKVDATVEKDLAGKFEVRGFPTIKFFIS----GKPVDYTGGRQTSDIINWLKKKSGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKAAAAFKKIAAEIEDVAFGITSEDSVFKEHKMKKD-GVLLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETSHKLFTGEEVQSYLMLFIKKEGAKDT-LDTFKAAAGEFKGKVLFIYLDTAKEENEHIMGFFGLKAADAPAMRLIQLG-EDLAKYKPESDTLDKSTITKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKKLAPIWDQLGEKFKDSKDIIIAKMDSTANEMEEVKIKSYPTLKYFPKGSDEIIEYDGERTLEELTKFVESGGKQEPPKKEEEEK----EEDD-DKKKDE--------L magusQFQ61177 MKFATVFSLTLLALVACEEVEQEEKVYVLKKKNFDNFIKENDFVLVEFYAPWCGHCKNLAPMYSKAAGKLMDEGSNIKLAKVDATVETDLAGKFEVKGYPTIKFFIS----GEPTDYTGGRQTSDIISWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKGAAAFKKIATKIEDVAFGITSEDSVFEEHKMKKD-GVVLFKKFDEGRSDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAQKIFAG-DIQNHLMLFVKKEEAKDT-LETFKAAAGEFKGKVLFIYLDVAKEENEHIMGFFGLKAADSPAMRLIQLG-EDLAKYKPESDSLDKSTINKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKKLAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVQIKSFPTLKYFPKGSDEIIEYDGERTLEELTKFVKSGGKQEPPKKEEEEK----EEDD-DKKKDE--------L litteratusARS01447 MKFATVFSLALLAFVACEEVEQEEKVYVLKTKNFDNFIKENEFVLVEFYAPWCGHCKQLAPQYSAAAGKLMDEGSNIKLAKVDATIEKDLAGKFEVKGFPTIKFFIN----GEPIEYTGGRQTSDIINWLKKKTGPPAKEVKTSEEAKTFIDSDEVIVMGFFKDQEGKGAAVFKKIAAEIEDVAFGFTSEDSVFKEHKMKKD-GVVLFKKFDEGRNDFSGDF-EEAAMSKFIKDNRLPLINEFTQETAQKIFTG-DVKTHLMLFVKKEGAKDI-LDTFKSAAGEFKGKVLFIYLDTAKEENEHIMGFFGLKAADAPAMRLIQLG-EDLAKYKPESDSLDKSTITKFVQDFLDGKLKPHLKSEEVPDDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKQLAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVQIRSFPTLKYFPKGSDEIIEYDGERTLEELTKFVESGGKQEPLKKEEEEK----EEDD-DKKKDE--------L ebraeusASF90532 MKFATVFSLTLLAFVACEEVEQEEKVYVLKTKNFDNFIEENEFVLVEFYAPWCGHCKQLAPAYSEAAGKLMDEGSNIKLAKVDATVERDLAEKFEVKGFPTIKFFIS----GKPMDYGGGRQTSEIINWLKKKTGPPAKNVKTSEEAKTFIDSDEVIVMGFFKDQEGKGAAALKKIAAEIEDVVFGITSEDSIFKEHKMKKD-GVVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQETAQKLFTG-DVQTHLMLFIKKEETKDT-LDTFKAVAGEFKGKVLFIYLDTAKTENEHIMGFFGLKAADAPAMRLIQLG-EDLAKYKPESDSLDKSTMTKFVQDFLDGKLKPHLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKELAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVRIESFPTLKYFPKGSDEIIEYHGERTLEELTKFVESGGKQEPPKKEEEEK----EEDD-DKKKEE--------L geographusAMM62652 MKFATVFSLTLLAFVACEEVEQDEKVYVLKTTNFDNFIKENEFVLVEFYAPWCGACKNLAPVYHEVAGKLMDEGSNIKLAKVDVTAETDLADKFNITGYPTIKFFIS----GEPMEYTGGRQTSDIINWLKKKTGPPAKDVKTSEEAKTFIDSDEVIVMGFFKDQEGKGAAAFKKMASKIEDVVFGITSEDSVFKEHKMKKD-GVVLFKKFDEGRNDFSGDF-EEAAMSKFVKDNRLPLINEFTQEIAEKLFTG-DVQSHLMLFVKKEETKDT-LDTFKAAAGEFKGKVLFIYLDTAKEESERIMEFFGLKAADTPAMRLIYLG-EDLAKYKPESDSLDKSTMTKFVQDFLDGKLKPYLKSEEVPEDWDAQPVKVLVSKNFKEVAMDKSKAVFVEFYAPWCGHCKELAPIWDQLGEKFKDSKDIIIAKMDSTANELEEVQIEGFPTLKYFPKGSDEIIRYDGKRTLEELTKFVESGGKQEPPKKEEEEK----EEDD-DKKKDE--------L lottiaXP_009065326 MK--CVLLILGFLALSVFGADEEDKVVVLTKDNFDKTIEENQFVLVEFYAPWCGHCKQLEPEYKKASIQLAKDGSDVVLGKVDATQESELAEKFEVRGYPTIKFFRG----GKPSDYSAGRQAADIVNWLKKKTGPPAAAIKSVAEGTKFIDGNDVVVIGFFKDEDSTAAKAFKNVASGNDDVPFGITSDDSVFKEHSVDRD-SIILFKKFDEGKNTFDGDF-TVEKIEAFVGENQLPLVVEFTQESAQKIFGG-KVKNHILLFVNKDDDFDKHLEQFKAPAKDFKGKVLFIYINTKDEDNARILEFFGLKSEDVPALRLITLT-EDMTKYVPEDKSITTENVKTFVQLFLDGSLKPHLLSEDVPEDWDKNPVKVLVGKNFHEVAKDKSKAVLIEFYAPWCGHCKQLVPIWDELGEKFKGNKDIVIAKMDATANELADVKVQSFPTIKYFPAGSDDVIDYNGARTVEGFSKFLESGGKEGAGAAEEEEEDEGEEEGEEEEGEDDGEEVPRDEL [Protein Disulfide Isomerase (PDI-A3)] /------------------------------------------PDI_a_PDI_a'_C domain-----------------------------------------/ A_0855_188 -LLAYFRPSAFMSPATMRRAVILFSCIVLA--VQASDVLEFTDSNFVSKIKELDVALVEFYAPWCGHCKRLAPEYEVAATKLKKSDPPVPLVKVDCTAETKTCQEYGVSGYPTLKIFKGGEFAKDYQGPRESKGIISTMQKEAGPASKELEDLKQYEDFLGRDTVCVVGFFADADSQMAKTFSKLADTHEGDIRFGHTTASAIMDKAKYK-DEVVLFRPKAMQNKFED--SAVKFTGDATKKSAIKEFLTQEHLGMCGIRTMNNAGDF---NKPTFVAFYDVDY-VKNPKGSNYWRNRV-MKVGKKLRDEGLKVFFGVSNKEEHSHELGECGLQDAEGDKPIVCAYDEKNRKFKMEEEFSVDSFEKFVRGVLNGEVEAYLKSEPVPENNDQP--VKVVVAKNFEELVNDPEKDVLIEFYAPWCGHCKSLAPKYDELAEKLKDETDIVIAKMDATANDPPSQYEVRGFPTIYFAPKGSKSSPKKYEGGREVNDFIKYLAKEATDELQGFDRKGKKKGGQKQ-KKKTEL A_0885_194 MLLAYFRPSAFTSPATMRRAVILFSCIVLA--VQASDVLEFTDSNFVSKIKELDVALVEFYAPWCGHCKRLAPEYEVAATKLKKSDPPVPLVKVDCTAETKTCQEYGVSGYPTLKIFKGGEFAKDYQGPRESKGIINTMQKEAGPASKELEDLKQYEDFLGRDTVCVVGFFADADSQMAKTFSKLADTHEGDIRFGHTTASAIMDKAKYK-DEVVLFRPKAMQNKFED--SAVKFTGDATKKSAIKEFLTQEHLGICGIRTMNNAGDF---NKPTFVAFYDVDY-VKNPKGSNYWRNRV-MKVGKKLRDEGLKVFFGVSNKEEHSHELGECGLQDAEGDKPIVCAYDEKNRKFKMEEEFSVDSFEKFVRGVLNGEVEAYLKSEPVPENNDQP--VKVVVAKNFEELVNDPEKDVLIEFYAPWCGHCKSLAPKYDELAEKLKDETDIVIAKMDATANDPPSQYEVRGFPTIYFAPKGSKSSPKKYEGGREVNDFIKYLAKEATDELQGFDRKGKKKGGQKQ-KKKTEL A_0039_289 MLLAYFRPSAFMSPATMRRAVILFSCIVLA--VQASDVLEFTDSNFVSKIKELDVALVEFYAPWCGHCKRLAPEYEVAATKLKKSDPPVPLVKVDCTAETKTCQEYGVSGYPTLKIFKGGEFAKDYQGPRESKGIISTMQKEAGPASKELEDLKQYEDFLGRDTVCVVGFFADADSQMAKTFSKLADTHEGDIRFGHTTASAIMDKAKYK-DEVVLFRPKAMQNKFED--SAVKFTGDATKKSAIKEFLTQEHLGMCGIRTMNNAGDF---NKPTFVAFYDVDY-VKNPKGSNYWRNRV-MKVGKKLRDEGLKVFFGVSNKEEHSQELGECGLQDAEGDKPIVCAYDEKNRKFKMEEEFSVDSFEKFVRGVLNGEVEAYLKSEPVPENNDQP--VKVVVAKNFEELVNDPEKDVLIEFYAPWCGHCKSLAPKYDELAEKLKDEADIVIAKMDATANDPPSQYEVRGFPTIYFAPKGSKSSPKKYEGGREVNDFIKYLAKEATDELHGFDRKGKKKGGQKQ-KKKTEL A_0875_174 MLLAYFRPSAFMSPATMRRAVILFSCIVLA--VQASDVLEFTDSNFVSKIKELDVALVEFYAPWCGHCKRLAPEYEVAATKLKKSDPPVPLVKVDCTAETKTCQEYGVSGYPTLKIFKGGEFAKDYQGPRESKGIISTMQKEAGPASKELEDLKQYEDFLGRDTVCVVGFFADADSQMAKTFSKLADTHEGDIRFGHTTASAIMDKAKYK-DEVVLFRPKAMQNKFED--SAVKFTGDATKKSAIKEFLTQEHLGICGIRTMNNAGDF---NKPTFVAFYDVDY-VKNPKGSNYWRNRV-MKVGKKLRDEGLKVFFGVSNKEEHSHELGECGLQDAEGDNPIVCAYDEKNRKFKMEEEFSVDSFEKFVRGVLNGEVEAYLKSEPVPENNDQP--VKVVVAKNFEELVNDPEKDVLIEFYAPWCGHCKSLAPKYDELAEKLKDEADIVIAKMDATANDPPSQYEVRGFPTIYFAPKGSKSSPKKYEGGREVNDFIKYLAKEATDELQGFDRKGKKKGGQKQ-KKKTEL A_0055_285 MLLAYFRPSAFMSPATMRRAVILFSCIVLA--VQARDVLEFTDSNFVSKIKELDVALVEFYAPWCGHCKRLAPEYEVAATKLKKSDPPVPLVKVDCTAETKTCQEYGVSGYPTLKIFKGGEFAKDYQGPRESKGIISTMQKEAGPASKELEDLKQYEDFLGRDTVCVVGFFADADSQMAKTFSKLADTHEGDIRFGHTTASAIMDKAKYK-DEVVLFRPKAMQNKFED--SAVKFTGDATKKSAIKEFLTQEHLGMCGIRTMNNAGDF---NKPTFVAFYDVDY-VKNPKGSNYWRNRV-MKVGKKLRDEGLKVFFGVSNKEEHSQELGECGLQDAEGDKPIVCAYDEKNRKFKMEEEFSVDSLEKFVRGVLNGEVEAYLKSEPVPENNDQP--VKVVVAKNFEELVNDPEKDVLIEFYAPWCGHCKSLAPKYDELAEKLKDEADIVIAKMDATANDPPSQYEVRGFPTIYFAPKGSKSSPKKYEGGREVNDFIKYLAKEATD------------------------ V_CG13_228 MLLAYFRPSAFTSPATMRRAVILFSCIVLA--VQASDVLEFTDLNFVSKIKELDVALVEFYAPWCGHCKRLAPEYEVAATKLKKSDPPVSLVKVDCTAETKTCQEYGVSGYPTLKIFKGGEFAKDYQGHRESKGIISTMQKEAGPASKELQDLKQYEDFLGRDTVCVVGFFADADSEMAKTFRKLADTHEGDVRFGHTTASAIMDKAKYK-DEVVLFRPKAMQNKFED--SAVKFTGDATKKSAIKEFLTQEHLGMCGIRTMNNAGDF---NKPTFVVFYDVDY-VKNPKGSNYWRNRV-MKVGKKLRDEGLKVFFGVSNKEEHSQELGECGLQDAEGDKPIVCAYDEKNRKFKMEEEFSVDSFEKFVRGVLNGEVEAYLKSEPVPENNDQP--VKVVVAKNFEELVNDPEKDVLIEFYAPWCGHCKSLAPKYDELAEKLKDETDIVIAKMDATANDPPSQYEVRGFPTIYFAPKGSKSSPKKYEGGREVNDFIKYLAKEATDELQGFDRKGKKKGGQKQ-KKKTEL V_1302_223 MLLAYFRPSAFTSPATMRRAVILFSCIVLA--VQASDVLEFTDLNFVSKIKELDVALVEFYAPWCGHCKRLAPEYEVAATKLKKSDPPVSLVKVDCTAETKTCQENGVSGYPTLKIFKGGEFAKDYQGPRESKGIISTMQREAGPASKELEDLKQYEDFLGRDTVCVVGFFADADSEMAKTFRKLADTHEGDIRFGHTTASAIMDKAKYK-DEVVLFRPKAMQNKFED--SAVKFTGEATKKSAIKEFLTQEHLGMCGIRTMNNAGDF---NKPTFVAFYDVDY-VKNPKGSNYWRNRV-MKVGKKLRDEGLKVFFGVSNKEEHSQELGECGLQDAEGDKPIVCAYDEKNRKFKMEEEFSVDSFEKFVRGVLNGEVEAYLKSEPVPENNDQP--VKVVVAKNFEELVNDPEKDVLIEFYAPWCGHCKSLAPKYDELAEKLKDETDIVIAKMDATANDPPSQYEVRGFPTIYFAPKGSKSSPKKYEGGREVNDFIKYLAKEATDELQGFDRKGKKKGGQKQKKKKTEL V_1278_115 MLLAYFRPSAFTSPATMRRAVILFSCIVLA--VQASDVLEFTDSNFVSKIKELDVALVEFYAPWCGHCKRLAPEYEVAATKLKKSDPPVSLVKVDCTAETKTCQENGVSGYPTLKIFKGGEFAKDYQGPRESKGIISTMQKEAGPASKELEDLKQYEDFLGRDTVCVVGFFADADSEMAKTFRKLADTHEGDIRFGHTTASAIMDKAKYK-DEVVLFRPKAMQNKFED--SAVKFTGEATKKSAIKEFLTQEHLGMCGIRTMNNAGDF---NKPTFVAFYDVDY-VKNPKGSNYWRNRV-MKVGKKLRDEGLKVFFGVSNKEEHSHELGECGLQDAEGDKPIVCAYDEKNRKFKMEEEFSVDSFEKFVRGVLNGEVEAYLKSEPVPENNDQP--VKVVVAKNFEELVNDPEKDVLIEFYAPWCGHCKSLAPKYDELAEKLKDETDIVIAKMDATANDPPSQYEVRGFPTIYFAPKGSKSSPKKYEGGREVNDFIKYLAKEATDELQGFDRKGKKKGGQKQKKKKTEL V_1258_175 MLLAYFRPSAFTSPATMRRAVILFSCIVLA--VQASDVLEFTDLNFVSKIKELDVALVEFYAPWCGHCKRLAPEYEVAATKLKKSDPPVSLVKVDCTAETKTCQENGVSGYPTLKIFKGGEFAKDYQGPRESKGIISTMQKEAGPASKELEDLKQYEDFLGRDTVCVVGFFADADSEMAKTFRKLADTHEGDIRFGHTTASAIMDKAKYK-DEVVLFRPKAMQNKFED--SAVKFTGEATKKSAIKEFLTQEHLGMCGIRTMNNAGDF---NKPTFVAFYDVDY-VKNPKGSNYWRNRV-MKVGKKLRDEGLKVFFGVSNKEEHSHELGECGLQDAEGDKPIVCAYDEKNRKFKMEEEFSVDSFEKFVRGVLNGEVEAYLKSEPVPENNDQP--VKVVVAKNFEELVNDPEKDVLIEFYAPWCGHCKSLAPKYDELAEKLKDETDIVIAKMDATANDPPSQYEVRGFPTIYFAPKGSKSSPKKYEGGREVNDFIKYLAKEATDELQGFDRKGKKKGGQKQKKKKTEL A_1387_037 -----------MSPATMRRAVILFSCIVLA--VQASDVLEFTDSNFVSKIKELDVALVEFYAPWCGHCKRLAPEYEVAATKLKKSDPPVPLVKVDCTAETKTCQEYGVSGYPTLKIFKGGEFAKDYQGPRESKGIISTMQKEAGPASKELEDLKQYEDFLGRDTVCVVGFFADADSQMAKTFSKLADTHEGDIRFGHTTASAIMDKAKYK-DEVVLFRPKAMQNKFED--SAVKFTGDATKKSAIKEFLTQEHLGMCGIRTMNNAGDF---NKPTFVAFYDVDY-VKNPKGSNYWRNRV-MKVGKKLRDEGLKVFFGVSNKEEHSQELGECGLQDAEGDKPIVCAYDEKNRKFKMEEEFSVDSFEKFVRGVLNGEVEAYLKSEPVPENNDQP--VKVVVAKNFEELVNDPEKDVLIEFYAPWCGHCKSLAPKYDELAEKLKDETDIVIAKMDATANDPPSQYEVRGFPTIYFAPKGSKSSPKKYEGGREVNDFIKYLAKEATDELQGFDRKGKKKGGQKQ-KKKTEL A_0520_012 ----------------MRRAVILFSCIVLA--VQASDVLEFTDSNFVSKIKELDVALVEFYAPWCGHCKRLAPEYEVAATKLKKSDPPVPLVKVDCTAETKTCQEYGVSGYPTLKIFKGGEFAKDYQGPRESKGIISTMQKEAGPASKELEDLKRYEDFLGRDTVCVVGFFADADSQMAKTFSKLADTHEGDIRFGHTTASAIMDKAKYK-DEVVLFRPKAMQNKFED--SAVKFTGDATKKSAIKEFLTQEHLGMCGIRTMNNAGDF---NKPTFVAFYDVDY-VKNPKGSNYWRNRV-MKVGKKLRDEGLKVFFGVSNKEEHSHELGECGLQDAEGDKPIVCAYDEKNRKFKMEEEFSVDSFEKFVRGVLNGEVEAYLKSEPVPENNDQP--VKVVVAKNFEELVNDPEKDVLIEFYAPWCGHCKSLAPKYDELAEKLKDETDIVIAKMDATANDPPSQYEVRGFPTIYFAPKGSKSSPKKYEGGREVNDFIKYLAKEATDELQGFDRKGKKKGGQKQ-KKKTEL A_0239_004 MLLAYFRPSACMSPATMRRAVILFSCIVLA--VQASDVLEFTDSNFVSKIKELDVALVEFYAPWCGHCKRLAPEYEVAATKLKKSDPPVPLVKVDCTAETKTCQEYGVSGYPTLKIFKGGEFAKDYQGPRESKGIISTMQKEAGPASKELEDLKQYEDFLGRDTVCVVGFFADADSQMAKTFSKLADTHEGDIRFGHTTASAIMDKAKYK-DEVVLFRPKAMQNKFED--SAVKFTGDATKKSAIKEFLTQEHLGICGIRTMNNAGDF---NKPTFVAFYDVDY-VKNPKGSNYWRNRV-MKVGKKLRDEGLKVFFGVSNKEEHSHELGECGLQDAEGDKPIVCAYDEKNRKFKMEEEFSVDSFEKFVRGVLNGEVEAYLKSEPVPENNDQP--VKVVVAKNFEELVNDPEKDVLIEFYAPWCGHCKSLAPKYDELAEKLKDETDIVIAKMDATANDPPSQYEVRGFPTIYFAPKGSKSSPKKYEGGREVNDFIKYLAKEATDELHGFDRKGKKKGGQKQ-KKKTEL A_0048_031 MLLAYFRPSAFMSPATMRRAVILFSCIVLA--VQASDVLEFTDSNFVSKIKELDVALVEFYAPWCGHCKRLAPEYEVAATKLKKSDPPVPLVKVDCTAETKTCQEYGVSGYPTLKIFKGGEFAKDYQGPRESKGIISTMQKEAGPASKELEDLKQYEDFLGRDTVCVVGFFADADSQMAKTFSKLADTHEGDIRFGHTTASAIMDKAKYK-DEVVLFRPKAMQNKFED--SAVKFTGNATKKSAIKEFLTQEHLGICGIRTMNNAGDF---NKPTFVAFYDVDY-VKNPKGSNYWRNRV-MKVGKKLRDEGLKVFFGVSNKEEHSHELGECGLQDAEGDKPIVCAYDEKNRKFKMEEEFSVDSFEKFVRGVLNGEVEAYLKSEPVPENNDQP--VKVVVAKNFEELVNDPEKDVLIEFYAPWCGHCKSLAPKYDELAEKLKDETDIVIAKMDATANDPPSQYEVRGFPTIYFAPKGSKSSPKKYEGGREVNDFIKYLAKEATDELQGFDRKGKKKGGQKQ-KKKTEL A_0025_374 ----------------MRRAVILFSCIVLA--VQASDVLEFTDSNFVSKIKELDVALVEFYAPWCGHCKRLAPEYEVAATKLKKSDPPVPLVKVDCTAETKTCQEYGVSGYPTLKIFKGGEFAKDYQGPRESKGIISTMQKEAGPASKELEDLKQYEDFLGRDTVCVVGFFADADSQMAKTFSKLADTHEGDIRFGHTTASAIMDKAKYK-DEVVLFRPKAMQNKFED--SAVKFTGNATKKSAIKEFLTQEHLGICGIRTMNNAGDF---NKPTFVAFYDVDY-VKNPKGSNYWRNRV-MKVGKKLRDEGLKVFFGVSNKEEHSHELGECGLQDAEGDKPIVCAYDEKNRKFKMEEEFSVDSFEKFVRGVLNGEVEAYLKSEPVPENNDQP--VKVVVAKNFEELVNDPEKDVLIEFYAPWCGHCKSLAPKYDELAEKLKDETDIVIAKMDATANDPPSQYEVRGFPTIYFAPKGSKSSPKKYEGGREVNDFIKYLAKEATDELQGFDRKGKKKGGQKQ-KKKTEL A_0031_327 MLLAYFRPSAFMSPATMRRAVILFSCIVLA--VQASDVLEFTDSNFVSKIKELDVALVEFYAPWCGHCKRLAPEYEVAATKLKKSDPPVPLVKVDCTAETKTCQEYGVSGYPTLKIFKGGEFAKDYQGPRESKGIISTMQKEAGPASKELEDLKQYEDFLGRDTVCVVGFFADADSQMAKTFSKLADTHEGDIRFGHTTASAIMDKAKYK-DEVVLFRPKAMQNKFED--SAVKFTGDATKKSAIKEFLTQEHLGMCGIRTMNNAGDF---NKPTFVAFYDVDY-VKNPKGSNYWRNRV-MKVGKKLRDEGLKVFFGVSNKEEHSHELGECGLQDAEGDKPIVCAYDEKNLKFKMEEEFSVDSFEKFVRGVLNGEVEAYLKSEPVPENNDQP--VKVVVAKNFEELVNDPEKDVLIEFYAPWCGHCKSLAPKYDELAEKLKDETDIVIAKMDATANDPPSQYEVRGFPTIYFAPKGSKSSPKKYEGGREVNDFIKYLAKE--------------------------- K_0010_152 MLLAYFRPSAFTSPATMRRAAILFSCIVLA--VQASDVLEFTDSNFKSKIKELDVALVEFYAPWCGHCKRLAPEYEVAATKLMKSDPPVPLVKVDCTAESETCKEYGVSGYPTLKIFKGGEFAKDYQGPRESKGIVNTMQKEAGPASKELEDFKQYEDFVGRDTVCVVGFFADADSEMAKTFSKLADTHEGDIRFGHTTASAIMDKANYK-DEIVLFRPKAMQNKFED--SAVKFTGDATKKPAIKEFLTQEHLGMCGIRTMNNAGDF---GKPTFVAFYNVDY-VKNPKGSNYWRNRV-MKVGKKLCDEGLKVFFGVSNKEEHDQELGECGLQNAEGDKPIVCAYDEKNRKFKMEEEFSVDSFEKFVRGVLNGEVEAYLKSEPVPENNDQP--VKVVVAKNFDDLVNDPEKDVLIEFYAPWCGHCKSLAPKYDELAEKLKDETDIVIAKMDATANDPPSQYEVRGFPTIYFAPKGSKSSPKKYEGGREVNDFIKYLAKEATDELQGFDRKGKKKGG--Q-KKKTEL ermineusAXL95652 ----------------MRRTVFLFSCIVLA--VQASDVLEFTDSNFVSKIKELDVALVEFYAPWCGHCKRLAPAYEVAATKLKKSDPPVSLVKVDCTAETKTCQEYGVSGYPTLKIFKGGEFAKDYQGPRESQDIFNTMQKEAGPASKELQDFKQYEDFLGRDTVCIVGFFADADSEMAKTFSKLADTHEGDVRFGHTTASAIMDKAKYK-DEIVLFRPKAMQNKFED--SAVKFTGDATKKSAIKEFLTQEHLGMCGIRTISNAGDF---SKPTFVAFYDVDY-LKNPKGSNYWRNRV-MKVGKKLRDEGLKVFFGVSNKEDHGHELGECGLQDAEGDKPIVCAYDEKNRRFKMEEEFSVDSFEKFVRGVLNGEVEAYLKSEPVPENNDQP--VKIVVAKNFDELVNDPEKDVLIEFYAPWCGHCKSLAPKYDELAEKLKDETDIVIAKMDATANDPPSQYEVRGFPTIYFAPKGSKSSPKKYEGGREVNDFIKYLAKEATDELQGFDRKGKKKGGQKQKKKKTEL magusQFQ61181 MLLAYFRPSAFTSPATMRRAVILFSCIVLA--VQASDVLEFTDSNFGSKIKELDVALVEFYAPWCGHCKRLAPEYEKAATRLTKSDPPVPLVKVDCTAETKTCQEYGVSGYPTLKIFKGGEFAKDYQGPRESNGIVSTMQKEAGPASKELKDFKEYENFLGRDTACVVGFFEDADSEVAKTFSKLADTNDGDIRFGHTTASAIMDKAKYK-DEIVLFRPKAMQNKFED--SAVKFTGDATKKSAIKEFLSQEHLGMCGIRTMSNAGDF---SKPTFVAFYDVDY-VKNPKGSNYWRNRV-MKVGKKLRDEGLKVFFGVSNKEEHGHELGECGLQDAEGDKPIVCAYDEKNRKFKMEEEFSVDSFEKFVRAVLNGEVEAYLKSEPVPENNDQP--VKVVVAKNFDELVNDPEKDVLIEFYAPWCGHCKSLAPKYDELAEKLQDETDIVIAKMDATANDPPSQYEVRGFPTIYFAPKGSKSSPKKYEGGREVNDFIKYLAKEATDELQGFDRKGKKKGGQKQKKKKTEL CrassostreaXP_011453191 ----------------MKAIVALLA-FVTS--TLASDVLEFTDSDFSSRIADHELILVEFFAPWCGHCKKLAPEYERAATSLKDNDPPVPLAKVDCTASEETCKKFGVSGYPTLKIFRAGEFSEEYGGPREADGIIKYMQTRAGPTSKELNNVADAEKFLSKADYGVIGFFEDGESELAKTFQKVADAMSTDLKFAHTSSKAVLDKYGFK-NDIVLYQPKRLRNKFEP--SELKYTDDATVYK-IKEWLNNNILGLCGHRTQSNAEKF---KKPLVVAFYDVDY-VKNEKGTNYWRNRV-MKVAKKIQDEGKKIFFAVSNSKDFSYELGEFGLGDVSGEKPVVAVRDERDRKYVMSDEFSMDNLEKFVRDFLDDKVEPYLKSEPVPDNTDAP--VKVVVAKNFDEIVNDSERDVLIEFYAPWCGHCKQLEPKYTELGEKLAEESGITIAKMDATANDVAKPYEVSGFPTIYFAPKGSKNSPKRYSGGREVDDFLKYLAKEATNELSGFDRDGKKKK-----KKKTEL LottiaXP_009056950 ----------------MKSLVFLISVFVAS--IAADDVLVFTDSDFSTKASEHDLALIEFYAPWCGHCKKLAPEYEKAASTLKSNDPPVALAKVDCTVEKDVCSKYGVSGYPTLKIFRNGEFSEDYNGPREAGGIVKLMKSKAGPTSTLLETLEQAEKIAKSSEYAAIGFFKSLDSELGKTFQKVADAISGDLKFAHTENADIMKKFGFK-DKIVLFRPKKFQSKFED--HQLEYKDDSKLHT-LKNWVQENILGLCSHRTPDNADKL---KKPLFVAYYDVDY-VKNEKGTNYWRNRV-MKVGKKLRDAGKNLYFGVSNSGEFAHEMSECGL-NSQGDKPKVCAWDSRDRKFAMSEEFSMETFEKFINDVLEGKLEPYLKSEPIPDNTDVP--VKTVVAKNFEEIVNDENKDVLIEFYAPWCGHCKSLAPKYEELAEALKDEKEITIAKMDATANDVSKPYDVTGFPTLYFVPKDKKDNPVKYNGGREVGDFIKYLAKEATNELSGYKRNGKKKK--------TEL BiomphalariaXP_013083422 ----------------MKLYITLLSLFVWTALASEDDVLVFTAANFDTEIVKYDVILVEFYAPWCGHCKNLKPEYEAAAGVLKKADPPVALAKVDCTEESSLCSRFGVSGYPTLKIFKNGEFSKEFGGERRKDSIVKEMNKEAGPVSKLLSTVEEAQKFLSKDTVGVIGFFSSEDSADAKSFLKVADQVS-EVRFAHTVSDEVKKELKQT-DGVVLFRPKVLQSKFEE--AEVRFTDTNTAK--LKSAIESEALGLCAERTQSNAANF---GKPLFVAYYNVDY-TKNPKGTNYWRNRI-MKVGKQIRDEGKTVYFAISNTDEMSRELEECGITERDGDKPVVCAWDSQNKKFRMTEKFSVEAFEQFIRDVLDNKVEPYLKSEPVPSANDEP--VKVVVAKTFDSIVNDESKDVLIEFYAPWCGHCKSLAPKYDELAEKLKDEPSIVIAKMDATANDVPSPYDVRGFPTIYYAPKGNKSSPKRYEGGREVDEFIKYLAKESTDGLQGYSKEGKKKKA---KKDKTDL AplysiaXP_005100750 ----------------MYSSVVLLGLLCFCG-AFADDVLVFTDANFGDEIAKYETILVKFYAPWCGHCKRLAPEYERAATTLKKQDPPVALAKVDCTVETNVCSKHGVSGYPTLKVFKNGELAKDYSGPREADGIVKYMVREAGPVSKKLESADDARNFLNKASVGVIGFFESESSSLAKAFLKVADKLS-DVRFAHTISKEVKEELKQTEDGIVLFRPKVLQSKFED--AEVRCEETSSEK--IQSFIQGESLGLCGERTMSNAENF---QKPLFVAYFNVDY-VKNPKGTNYWRNRV-MKVGKKIKDEGETVYFAISGLDEMSRELEECGIEDRNGDKPVVCAWNAKNQKFKMTEEFSMDSFEQFVRDVLAGKVEAYMKSEPIPEDNDTPGKVKVVVGKNFDEIVNNEDKDVLIEFYAPWCGHCKSLAPKYDELAEKLKDEENVVIAKMDATANDVPPNYEVRGFPTIYFAPKGNKSTPKKYEGGREVDDFVKYLSKEATDGLKSVSKDSKKKK----KDKNVEL [Protein Disulfide Isomerase (PDI-A4)] /-----YbbN domain----/ /------------------------------------------PDI_a_PDI_a'_C domain----------------------------------------/ A_0039_215 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ALKFYLPEDDISVLAFFESEADDLLQVYQDALHDKREEYTLGYTTDPALFKQYKANPKSILVLNPERYYTKFEPKWHILKLEEDSSSDDINQFIHDHQFPLVGAYDGKLNQRYTQASPVCIFFYTVDWSFDHREGTQLWRHKIAEIAKDYKEIKFAIASDESNDYLLKQFGLEYSGEEMSVGIIA-DGKKYPMEAMEEFDSDQIREFLDEFRKGKLVPHVKSQPIPKKQQGPVKVVVGKTFEKIVQDTKKDVLIELYAPWCGHCKNLEPVYKELAKKFKPAKNLVFAKMDATANDVPDEYKVEGFPTIYFAPANKKSVPIKYEGG-RALEDFEKFLKEKATVSL-G-SLKDEL--------------------- A_0055_290 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKAGPEPIILAKVDATAETELASQYGVSGYPTFKVFRKGRAFEYKGQRE-QYEIVSYMNKQRGEPAKPVDK-EALKFYLPEDDISVLAFFESEADDLLQVYQDALHDKREEYTLGYTTDPALFKQYKANPKSILVLNPERYYTKFEPKWHILKLEEDSSSDDINQFIHDHQFPLVGAYDGKLNQRYTQASPVCIFFYTVDWSFDHREGTQLWRHKIAEIAKDYKEIKFAIASDESNDYLLKQFGLEYSGEEMSVGIIA-DGKKYPMEAMEEFDSDQIREFLDEFRKGKLVPHVKSQPIPKKQQGPVKVVVGKTFEKIVQDTKKDVLIELYAPWCGHCKNLEPVYKELAKKFKPAKNLVFAKMDATANDVPDEYKVEGFPTIYFAPANKKSVPIKYEGG-RALEDFEKFLKEKATVSL-G-SLKDEL--------------------- A_0239_368 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YMNKQRGEPAKPVDK-EALKFYLPEDDISVLAFFESEADDLLQVYQDALHDKREEYTLGYTTDPALFKQYKANPKSILVLNPERYYTKFEPKWHILKLEEDSSSDDINQFIHDHQFPLVGAYDGKLNQRYTQANPVCIFFYTVDWSFDHRESTQLWRHKIAEIAKDYKEIKFAIASDESNDYLLKQFGLEYSGEEMSVGIIA-DGKKYPMEAMEEFDSDQIREFLDEFRKGKLVPHVKSQPIPKKQQGPVKVVVGKTFEKIVQDTKKDVLIELYAPWCGHCKNLEPVYKELAKKFKPAKNLVIAKMDATANDVPDEYKVEGFPTIYFAPANKKSVPIKYEGG-RALEDFEKFLKEKATVSL-G-SLKDEL--------------------- ermineusAXL95384 -------------------------------------------------------------------------------------------------------------------------------------------------------------------MKERASPSWAPEPDAVVVLTKENFTNIVNQEDLMLVEFYAPWCGHCKSLAPKYEKAAKALKAGPEPIILAKVDATAETELASQYGVSGYPSLKVFRKGRAFEYKGQRE-QYEIVSYMNKQRGEPAKPVDK-EALKFYLPEDDISVLAFFESEADDLLQVYQDALHDKREEYTLGYTTDPVLFKQYKANPKSLLVLNPERYYTKFEPKWHILKLEEDSSSDDINQFIHDHQFPLVGAYDGKLNQRYTQASPVCIFFYTVDWSFDHREATQLWRHKIAEIAKDYKEIKFAVASDESNDYLLKQFGLEYSGEEMSVGIIA-DGKKYPMEAMEEFDSDQIREFLDEFRKGKLVPHVKSQPIPKKQQGPVKVVVGKTFEKIVQDTKKDVLIELYAPWCGHCKNLEPVYKELAKKFKPAKNLVIAKMDATANDVPDEYKVEGFPTIYFAPANKKSVPIKYEGG-RALEDFEKFLKEKATVSL-G-SLKDEL--------------------- magus DAC80629.1 M--------------------DPKKVLLLTFALFLLIVNISCEEEESEDVSETESGTDEDDDGVTVLNKGNFADFIESTDTVLVEFYAPWCGHCKHLAPEYAAAAKELKQMDPPVLLAKVDATVESELAQEHEVTGYPTLKFFKNGKGYEYDGPRVQQGIVSYMKERASPTWAPEPDAVVVLTKENFTNIVNQEDLMLVEFYAPWCGHCKSLAPKYEKAAKVLKAGPEPIVLAKVDATAETELASQYGVSGYPTLKVFRKGRAFEYKGQRE-QYEIVSYMNKQRGEPAKPVDK-EALKFYLPEDDISVLAFFESEADDLLQVYQDALHDKREEYTLGYTTDPALFKRYKANPKSILVLNPERYYTKFEPKWHILKLEEDSSSDDINQFIHDHQFPLVGAYDGKLNQRYTQASPVCIFFYTVDWSFDHREATQSWRHKIAEIAKDYKEIKFAVANDESNDYLLKQFGLEYSGEEMSVGIIA-DGKKYPMEAMEEFDSDQIREFLDEFRKGKLVPHVKSQPIPKKQQGPVKVVVGKTFEKIVQDTKKDVLIELYAPWCGHCKNLEPVYKELAKKFKPAKNLVIAKMDATANDVPDEYKVEGFPTIYFAPANKKSVPIKYEGG-RALEDFEKFLKEKATVSL-G-SLKDEL--------------------- LottiaXP_009048109 M------------------------------------------------LLVEDGDSPTEEDDVLLLNQENFDEVINSRDTVLVEFYAPWCGHCKSLAPEYALAAKELKQLAPPIILAKVDATIEETLATRFSVTGYPTLKFFKNGNPHDYDGPRQKNGIVSYMKERGNPSWKPPPEAVITLNTDNFADTINNEELMLVEFYAPWCGHCKQLAPVYEKAAQELKKATPAIPLAKVDATQNTELAKEYGVTGYPTLKIFRKGRPKDYGGSRD-QRGIVNYMLSQAGEAARLLPTLSALKRFKQLQFITVIGFFDSEEDPNLRIYMDAANDMRDDFTFGYVLDDSIRNDYKVNVGSVIVLNPERFFTKFEPKWHVLN-KADLSVSDITEFVKNHQIPLVGEYSTSTQKFYGDFKPLCLVFYTVDWSHDHREATQLWRNKIASIAKDYKSVTFAVADEESHDHLLKEFNLEDSPEDINIGIIGKDNKRYRMEPMEDFESDEVREFLDSFIAGKLTYEVKSQPVPKKQSGPLKVVVGKTFKDIVLDKSKDVLIEFYAPWCGHCKKLEPVFNKLAKQVKDQKNLIVAKLDATANDVPDEFKVQGFPTIYFATAKDKKNPIKFDGGQREIADFEKFMREHATVSF-GKSSKEEL--------------------- BiomphalariaXP_013089019 MHYSLNIAILFIAILSLLSNALADADVDDVTVKANEPTNADLDADKDSENSDEGGSLRYEES-VLVLNGDNFDDVIKANPVVLVEFYAPWCGHCKNLAPEYSAAAKELASSDPPVVLAKVDATVHSELAQRFDVTGYPTLKFFKNGKEYPYEGPRETQGIISYMKERAKPDWAPEPDAVVTLTQTNFDEVINANDLILVEFYAPWCGHCKRLAPTYEKAAKSLLKNNPPITLAKVDATKEADLAKKYEISGYPTLKIFRKGKPSDYKGKYESEYDIVVHMRNQLGDGAKEIASLKALKEFFSVDDVTVIGFFESKEEPLAQPYKDFSDENREDYTFGIVYNKEAREAYKIKPNSVVVFNSERFYTKYEPKWHVLEIKEETSAVDVKSFIEKHHLPLVGHYHGSLIPRYQGKKPLCLVFYTVDFSFEHREATQFWRNKIAAIAKKFPDITFAVVDDETNSPLMEEFGLGDSGEDVNVGLFGADGKRYGMKPMEEFDSDDIIEFLNKYKKGKLKPYVKSQRAPNKQTGPVTVVVAHTFGDIVLDNKKDVLIELYAPWCGHCKNLEPIYNDLAKKLKAEKNLVIAKMDATANDLPDNYSSTGFPTIYFAPANNKKSPIKYEGE-RTLEAFEKFLKEQATVSF-GKVVKEEL--------------------- ElysiaRUS73745 M-----------------------------------------------------------EDSVIVLTESNFDDQVQKHPILLVEFYAPWCGHCKNLAPEYAAAAAVLAKHDPPVMLGKVDATVHSELAQRFEVSGYPTLRFFKDGKDFEYDGPRNKDGIVDYMRERASPDWQPEPDAVLTLTNDDFDEIVDNEKLILVEFYAPWCGHCKRLAPLYEKAAKQLKKEDPPILLAKVDATKDSDLASRFDVTGYPTLKLFRNGRASDYKGQRDSEYDIVNFMLKQVGDGAKELKTSKALKEFIYEDDITVVGFFDTKDNAKVAVYKEEADDYRDEYQFGIVFDEVIRKAYKVNPNSVVVFNPERYYTKYEPKWYVLEIKDDTKSSDIHKFVSDHSLPLVGAYAPPLQKRYDEKRPLCLVFYSVDFSFEHKEATQFWRKKIAAVANKYPDITFAVADDETNAKMLETAGLGDSGEELNVLLLGPDDEKFPMEPMEEYDSDDLKEFLDKYKKGKLKPYLKSERAPKKQSGPVTVVVGSTFEKIVMDPSKDVLVELYAPWCGHCKNLEPKYQALAKKLKKEKNLVIAKMDATANDLPAAYKASGFPTIYFAPSNSKQSPLKYEGG-RDVDDFIDYLKDHATVSF-GKGGKDEL--------------------- PomaceaPVD30097 MKVSKFLVSLFLAGLLLVAFVSCD----------------NEDDDEDTEADDNDADEDGDDDGVLVLTKDNFSDFIKDTDTALVEFYAPWCGHCKSLAPVYAAAAKELKVSDPPVILAKVDATVETDLAQQYDVTGYPTLKFFKRGSSYDYDGGRDKTGIVNFMKVIASPDWKPEPEAVVVLTQENFTEVVSREELMLVEFYAPWCGHCKQLAPKYEKAAKQLRQSEYPIILAKVDATVETDLAAQYGVNGYPTLKVFRKGRQFDYKGQRE-TYDIISYMESQRGDPAKPVVGLKALKAFLKEDDINVLGIFDSETDPRLQTFQDSLQDIREEYRSGFTTDETIKNHYKANSGSVLVIIPERYYTSYEPKWKVFEIKEDTKPDEITKFIVDNEFPLVGSMDSNNQARYAKRSPLCLFFYDVDWGFDHREATQMWRKKIASIAKDFRNITFAVADEEKNMQMLKELGLEDSSEEINIGILA-NGKKYPMEPMEEFDPDEVREFLNQFLKGKVEPHIKSQPVPKKQEGPVTIVVGKSFDKIVKDTSKDVLIELYAPWCGHCKKLEPVYKDLAKKLKSVKNLVIAKMDATANDVPYNYPAEGFPTIYFAPTNNKDKPLKYEGG-RELKDFISFLKEKATVSL-GKIKMNCDCTGCNYLQASEADNLPCNMPA AplisiaXP_005099456 MAVLKASVIIFCLLLSISISVAN-------------ADVEVDDATADDEGAEDTEFVQDEES-VLVLTNDNFDSVVNKHETILVEFYAPWCGHCKSLAPEYAAAAAALLENDPPVALGKVDATVHTELAQRFEVQGYPTLRFFKNGKDYEYDGPRFKDGIVEFMQKIAKPDWAPEPEAVITLTKDDFDEVTENEEIMIVEFYAPWCGHCKRLAPIYEKAAKQMKKNDPPVIFAKVDATKDSELASRFGVTGYPTLKIFKKGRPFEYKGERNSEYDFISAVTKYMGDGAKEIFSLKMLKDVFPPDDITVVGFFQNAEDPGIQSYKDVADELRDDYKFGITFDEASRKAYKVNPGSVVVFNAERFYTKFEAKWHVLSVKDDTTVAEVKRFVESHQVPLVGHYAKDQVKRYDTLRPLCLVFYTVNFSFDYRDVTQMWRNKIAAIAKNYPDITFAVADDEEYANLMIDFGLGDSGEEMNFGLIGSDGKKYGMEPMEEFDSEAISEFLDSFKKGKLKPFIKSQRAPKKQSGPVTVVVGNTFEQIVKDSKKDVLIELYAPWCGHCKKLEPAYAALAKKLKKEKNLVIAKMDATANDMPDEYKAEGFPTIYFAPSNKKDQPLKYDGG-REVDDFEKYLKKHATVSF-SNAAKEEL--------------------- CrassostreaXP_011419262 MAWKKYLWLLTVIALLTVSSVKAE------------------------DDVEEKEDEEKEESDVLVLTKDNFDKVINDNDNVMVEFYAPWCGHCKSLEPLYAKAAQVLKTWDPPVPLAKVDATIESDLASRFDVSGYPTLKFFKKGVPYDYDDARTTEGLIRYVKERSDPDWKPPPEAVVTLTKDNFKDFINN-DLSLVEFYAPWCGHCKALAPSYEKAAKQLNIQSEPIPLGKVDATVETELASEYEVSGYPTLFLFRKGKKYEYNGPRD-ETGIVNYMIMQQGEASKLKLSVKDVKSSMKQDEIYVMGFFDNLNDPKLRMYMDAANAMREEFSFGHTLDPKIGDAYKTNPQTVLVFTPERYYTKYEPKWHVMKLDNIKDEGDIVEFVRKREVPLVGQYKANNIKLYQKYRPLCFVFYTVDWSFDHRDATQLWRNKVAKIANNHKEVKFAIADEDEHSHLLAEFGLDDSGEEINIACYGPDGKKYPMEPMEEWEDDEVEEYITKMKKGKLTPHLKSQPIPKRQDSPVKTVVGKSFDKIVKDKSKDVLIELYAPWCGHCKQLEPIYKELATKVKKEKNLVIAKMDATANDVPEAFKAEGFPTIYFAPSNNKDNPVKYSGG-RTVDDFMKYLKEHATVAFKGK---DEL--------------------- [Protein Disulfide Isomerase (PDI-A5)] /-----------------------------------Thioredoxin (YbbN) domain----------------------------------------/ /------------------------------------------PDI_a_PDIR domain-----------------------------------------/ A_0875_155 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MFYAPWCGHCKKAKPEFMAAAAKFRDDGKVMFGAVDCTTQQGICSAHDVTGYPTFKYFNY-NKNSQKYMGGREENDFVNFMRDPLSPSP-SPPTA----STKPEEDWADIPGKDFIGFLTKDTFDSFVLSQGSVLVMFYAPWCGHCKRMKPAFGQAASVIVEEKLGALAAVDATIEQQLADRFEIRGYPTLKYFKGGKYAFEYSGGRTADDFIAFLRSP--------------------DAPPTTPSPEPQWSDIV---SDVHHLTDTSFDEFIAANKKTLVMFYSPGCGHCKKMKPDYMTAATRLKEKVPDARLAAVDATRFKDLARKYHIKGYPNLKYFEDGALKADYKSGRSAEDLVEFFSTA----------------------------------------------------------------------------------------------------------------------SDKKDEL A_0855_170 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SPKPPEEPKKEAEWAEEPSEVVHLEDDNFDDYIKEHPSVLVMFYAPWCGHCKKMKPGYTEAAQLIKDQEIPSVLAAVDATKHRKLADTYNIKGFPTLKYFKDGEFAFDVNERDKDKIIDFVKDPKEPPPPPAPEPSWEEVDSDVIHLNEENFKPTLKKRKHALIMFYAPWCGHCKKAKPEFMAAAAKFRDDGKVMFGAVDCTTQQGICSAHDVTGYPTFKYFNY-NKNSQKYMGGREENDFVNFMRDPLSPSP-SPPTA----STKPEEDWADIPGKDFIGFLTKDTFDSFVLSQGSVLVMFYAPWCGHCKRMKPAFGQAASVIVEEKLGALAAVDATIEQQLADRFEIRGYPTLKYFKGGKYAFEYSGGRTADDFIAFLRNP--------------------DAPPTTPSPEPQWSDIV---SDVHHLTDTSFDEFIAANKKTLVMFYSPGCGHCKKMKPDYMTAATRLKEKVPDARLAAVDATRFKDLARKYHIKGYPNLKYFEDGALKADYKSGRSAEDLVEFFSTA----------------------------------------------------------------------------------------------------------------------SDKKDEL A_0039_255 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MHCDSGCLVHSPKPPEEPKKEAEWAEEPSEVVHLEDDNFDDYIKEHPSVLVMFYAPWCGHCKKMKPGYTEAAQLIKDQEIPSVLAAVDATKHRKLADTYNIKGFPTLKYFKDGEFAFDVNERDKDKIIDFVKDPKEPPPPPAPEPSWEEVDSDVIHLNEENFKPTLKKRKHALIMFYAPWCGHCKKAKPEFMAAAAKFRDDGKVMFGAVDCTTQQGICSAHDVTGYPTFKYFNY-NKNSQKYMGGREENDFVNFMRDPLSPSP-SPPTA----STKPEEDWADIPGKDFIGFLTKDTFDSFVLSQGSVLVMFYAPWCGHCKKMKPAFGQAASVIVEEKLGALAAVDATIEQQLADRFEIRGYPTLKYFKRGKYAFEYSGGRTADDFIAFLRNP--------------------DAPPTTPSPEPQWSDIV---SDVHHLTDTSFDEFIAANKKTLVMFYSPGCGHCKKMKPDYMTAATRLKEKVPDARLAAVDATRFKDLARKYHIKGYPTLKYFEDGALKADYKSGRSAEDLVEFFSTA----------------------------------------------------------------------------------------------------------------------SDKKDEL A_0855_171 ---------------------------------------------------------------------------------------------------------------------------------------MVNFLMDPTGDIPWDEDLTATDVVHIYTEDGLNKLLKKDKSAALVMFYAPWCGYCKRLKPDFAAAATEVKGKANLVGIDVDKPHMMGLRTLYNITGFPTLYYFEKGKVKYRYGGENSKDGIVSWLSNPKPPEEPKKEAEWAEEPSEVVHLEDDNFDDYIKEHPSVLVMFYAPWCGHCKKMKPGYTEAAQLIKDQEIPSVLAAVDATKHRKLADTYNIKGFPTLKYFKDGEFAFDVNERDKDKIIDFVKDPKEPPPPPAPEPSWEEVDSDVIHLNEENFKPTLKKRKHALIMFYAPWCGHCKKAKPEFMAAAAKFRDDGKVMFGAVDCTTQQGICSAHDVTGYPTFKYFNY-NKNSQKYMGGREENDFVNFMRDPLSPSP-SPPTA----STKPEEDWADIPGKDFIGFLTKDTFDSFVLSQGSVLVMFYAPWCGHCKRMKPAFGQAASVIVEEKLGALAAVDATIEQQLADRFEIRGYPTLKYFKGGKYAFEYSGGRTADDFIAFLRNP--------------------DAPPTTPSPEPQWSDIV---SDVHHLTDTSFDEFIAANKKTLVMFYSPGCGHCKKMKPDYMTAATRLKEKVPDARLAAVDATRFKDLARKYHIKGYPNLKYFEDGALKADYKSGRSAEDLVEFFSTA----------------------------------------------------------------------------------------------------------------------SDKKDEL A_0039_254 ---------------------------------------------------------------------------------------------------------------------------------------MVNFLMDPTGDIPWDEDLTATDVVHIYTEDGLNKLLKKDKSAALVMFYAPWCGYCKRLKPDFAAAATEVKGKANLVGIDVDKPHMMGLRTLYNITGFPTLYYFEKGKVKYRYGGENSKDGIVSWLSNPKPPEEPKKEAEWAEEPSEVVHLEDDNFDDYIKEHPSVLVMFYAPWCGHCKKMKPGYTEAAQLIKDQEIPSVLAAVDATKHRKLADTYNIKGFPTLKYFKDGEFAFDVNERDKDKIIDFVKDPKEPPPPPAPEPSWEEVDSDVIHLNEENFKPTLKKRKHALIMFYAPWCGHCKKAKPEFMAAAAKFRDDGKVMFGAVDCTTQQGICSAHDVTGYPTFKYFNY-NKNSQKYMGGREENDFVNFMRDPLSPSP-SPPTA----STKPEEDWADIPGKDFIGFLTKDTFDSFVLSQGSVLVMFYAPWCGHCKKMKPAFGQAASVIVEEKLGALAAVDATIEQQLADRFEIRGYPTLKYFKRGKYAFEYSGGRTADDFIAFLRNP--------------------DAPPTTPSPEPQWSDIV---SDVHHLTDTSFDEFIAANKKTLVMFYSPGCGHCKKMKPDYMTAATRLKEKVPDARLAAVDATRFKDLARKYHIKGYPTLKYFEDGALKADYKSGRSAEDLVEFFSTA----------------------------------------------------------------------------------------------------------------------SDKKDEL A_0055_279 ---------------------------------------------------------------------------------------------------------------------------------------MVNFLMDPTGDIPWDEDLTATDVVHIYTEDGLNKLLKKDKSAALVMFYAPWCGYCKRLKPDFAAAATEVKGKANLVGIDVDKPHMMGLRTLYNITGFPTLYYFEKGKVKYRYGGENSKDGIVSWLSNPKPPEEPKKEAEWAEEPSEVVHLEDDNFDDYIKEHPSVLVMFYAPWCGHCKKMKPGYTEAAQLIKDQEIPSVLAAVDATKHRKLADTYNIKGFPTLKYFKDGEFAFDVNERDKDKIIDFVKDPKEPPPPPAPEPSWEEVDSDVIHLNEENFKPMLKKRKHALIMFYAPWCGHCKKAKPEFMAAAAKFRDDGKVMFGAVDCTTQQGICSAHDVTGYPTFKYFNY-NKNSQKYMGGREENDFVNFMRDPLSPSP-SPPTA----STKPEEDWADIPGKDFIGFLTKDTFDSFVLSQGSVLVMFYAPWCGHCKRMKPAFGQAASVIVEEKLGALAAVDATIEQQLADRFEIRGYPTLKYFKRGKYAFEYSGGRTADDFIAFLRNP--------------------DAPPTTPSPEPQWSDIV---SDVHHLTDTSFDEFIAANKKTLVMFYSPGCGHCKKMKPDYMTAATRLKEKVPDARLAAVDATRFKDLARKYHIKGYPNLKYFEDGALKADYKSGRSAEDLVEFFSTA----------------------------------------------------------------------------------------------------------------------SDKKDEL V_1302_231 ---------------------------------------------------------------------------------------------------------------------------------------MVNFLMDPTGDIPWDEDLTATDVVHIDTEDGLNKLLKKDKSAALVMFYAPWCGYCKRLKPDFAAAATEVKGKANLVGIDVDKPHMMGLRTLYNITGFPTLYYFEKGKVKYRYGGENSKDGIVSWLSNPKPPEEPKKEAEWAEEPSEVVHLEDDNFDDYIKEHPSVLVMFYAPWCGHCKKMKPGYTEAAQLIKDQEIPSVLAAVDATKHRKLADTYNIKGFPTLKYFKDGEFAFDVNERDKDKIIDFVKDPKEPPPPPAPEPSWEEVDSDVIHLNEENFKPTLKKRKHALIMFYAPWCGHCKKAKPEFMAAAAKFRDDGKVMFGAVDCTTQQGICSAHDVTGYPTFKYFNY-NKNSQKYMGGREENDFVNFMRDPLSPSP-SPPTA----STKPEEDWADIPGKDFIGFLTKDTFDSFVLSQGSVLVMFYAPWCGHCKRMKPAFGQAASMIVEEKLGALAAVDATIEQQLADRFEIRGYPTLKYFKGGKYAFEYSGGRTADDFIAFLRNP--------------------DAPPTTPSPEPQWSDIV---SDVHHLTDTSFDEFIAANKKTLVMFYSPGCGHCKKMKPDYMTAATRLKEKVPDARLAAVDATRFKDLARKYHIKGYPTLKYFEDGALKADYKSGRSAEDLVEFFSTA----------------------------------------------------------------------------------------------------------------------SDKKDEL V_1258_178 ---------------------------------------------------------------------------------------------------------------------------------------MVNFLMDPTGDIPWDEDLTATDVVHIDTEDGLNKLLKKDKSAALVMFYAPWCGYCKRLKPDFAAAATEVKGKANLVGIDVDKPHMMGLRTLYNITGFPTLYYFEKGKVKYRYGGENSKDGIVSWLSNPKPPEEPKKEAEWAEEPSEVVHLEDDNFDDYIKEHPSVLVMFYAPWCGHCKKMKPGYTEAAQLIKDQEIPSVLAAVDATKHRKLADTYNIKGFPTLKYFKDGEFAFDVNERDKDKIIDFVKDPKEPPPPPAPEPSWEEVDSDVIHLNEENFKPTLKKRKHALIMFYAPWCGHCKKAKPEFMAAAAKFRDDGKVMFGAVDCTTQQGICSAHDVTGYPTFKYFNY-NKNSQKYMGGREENDFVNFMRDPLSPSP-SPPTA----STKPEEDWADIPGKDFIGFLTKDTFDSFVLSQGSVLVMFYAPWCGHCKRMKPAFGQAASMIVEEKLGALAAVDATIEQQLADRFEIRGYPTLKYFKGGKYAFEYSGGRTADDFIAFLRNP--------------------DAPPTTPSPEPQWSDIV---SDVHHLTDTSFDEFIAANKKTLVMFYSPGCGHCKKMKPDYMTAATRLKEKVPDARLAAVDATRFKDLARKYHIKGYPTLKYFEDGALKADYKSGRSAEDLVEFFSTA----------------------------------------------------------------------------------------------------------------------SDKKDEL A_0885_186 ---------------------------------------------------------------------------------------------------------------------------------------MVNFLMDPTGDIPWDEDLTATDVVHIYTEDGLNKLLKKDKSAALVMFYAPWCGYCKRLKPDFAAAATEVKGKANLVGIDVDKPHMMGLRTLYNITGFPTLYYFEKGKVKYRYGGENSKDGIVSWLSNPKPPEEPKKEAEWAEEPSEVVHLEDDNFDDYIKEHPSVLVMFYAPWCGHCKKMKPGYTEAAQLIKDQEIPSVLAAVDATKHRKLADTYNIKGFPTLKYFKDGEFAFDVNERDKDKIIDFVKDPKEPPPPPAPEPSWEEVDSDVIHLNEENFKPMLKKRKHALIMFYAPWCGHCKKAKPEFMAAAVKFRDDGKVMFGAVDCTTQQGICSAHDVTGYPTFKYFNY-NKNSQKYMGGREENDFVNFMRDPLSPSP-SPPTA----STKPEEDWADIPGKDFIGFLTKDTFDSFVLSQGSVLVMFYAPWCGHCKRMKPAFGQAASVIVEEKLGALAAVDATIEQQLADRFEIRGYPTLKYFKGGKYAFEYSGGRTADDFIAFLRNP--------------------DAPPTTPSPEPQWSDIV---SDVHHLTDTSFDEFIAANKKTLVMFYSPGCGHCKKMKPDYMTAATRLKEKVPDARLAAVDATRFKDLARKYHIKGYPTLKYFEDGALKADYKSGRSAEDLVEFFSTA----------------------------------------------------------------------------------------------------------------------SDKKDEL V_1278_149 ---------------------------------------------------------------------------------------------------------------------------------------MVNFLMDPTGDIPWDEDLTATDVVHIDTEDGLNKLLKKDKSAALVMFYAPWCGYCKRLKPDFAAAATEVKGKANLVGIDVDKPHMMGLRTLYNITGFPTLYYFEKGKVKYRYGGENSKDGIVSWLSNPKPPEEPKKEAEWAEEPSEVVHLEDDNFDDYIKEHPSVLVMFYAPWCGHCKKMKPGYTEAAQLIKDQEIPSVLAAVDATKHRKLADTYNIKGFPTLKYFKDGEFAFDVNERDKDKIIDFVKDPKEPPPPPAPEPSWEEVDSDVIHLNEENFKPTLKKRKHALIMFYAPWCGHCKKAKPEFMAAAAKFRDDGKVMFGAVDCTTQQGICSAHDVTGYPTFKYFNY-NKNSQKYMGGREENDFVNFMRDPLSPSP-SPPTA----STKPEEDWADIPGKDFIGFLTKDTFDSFVLSQGSVLVMFYAPWCGHCKRMKPAFGQAASVIVEEKLGALAAVDATIEQQLADRFEIRGYPTLKYFKGGKYAFEYSGGRTADDFIAFLRNP--------------------DAPPTTPSPEPQWSDIV---SDVHHLTDTSFDEFIAANKKTLVMFYSPGCGHCKKMKPDYMTAATRLKEKVPDARLAAVDATRFKDLARKYHIKGYPTLKYFEDGALKADYKSGRSAEDLVEFFSTA----------------------------------------------------------------------------------------------------------------------SDKKDEL V_CG13_297 ---------------------------------------------------------------------------------------------------------------------------------------MVNFLMDPTGDIPWDEDLTATDVVHIDTEDGLNKLLKKDKSAALVMFYAPWCGYCKRLKPDFAAAATEVKGKANLVGIDVDKPHMMGLRTLYNITGFPTLYYLEKGKVKYRYGGENSKDGIVSWLSNPKPPEEPKKEAEWAEEPSEVVHLEDDNFDDYIKEHPSVLVMFYAPWCGHCKKMKPGYTEAAQLIKDQEIPSVLAAVDATKHRKLADTYNIKGFPTLKYFKDGEFAFDVNERDKDKIIDFVKDPKEPPPPPAPEPSWEEVDSDVIHLNEENFKPTLKKRKHALIMFYAPWCGHCKKAKPEFMAAAAKFRDDGKVMFGAVDCTTQQGICSAHDVTGYPTFKYFNY-NKNSQKYMGGREENDFVNFMRDPLSPSP-SPPTA----STKPEEDWADIPGKDFIGFLTKDTFDSFVLSQGSVLVMFYAPWCGHCKRMKPAFGQAASVIVEEKLGALAAVDATIEQQLADRFEIRGYPTLKYFKGGKYAFEYSGGRTADDFIAFLRNP--------------------DAPPTTPSPEPQWSDIV---SDVHHLTDTSFDEFIAANKKTLVMFYSPGCGHCKKMKPDYMTAATRLKEKVPDARLAAVDATRFKDLARKYHIKGYPTLKYFEDGALKADYKSGRSAEDLVEFFSTA----------------------------------------------------------------------------------------------------------------------SDKKDEL A_0239_037 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MHCDSGCLVHSPKPPEEPKKEAEWAEEPSEVVHLEDDNFDDYIKEHPSVLVMFYAPWCGHCKKMKPGYTEAAQLIKDQEIPSVLAAVDATKHRKLADTYNIKGFPTLKYFKDGEFAFDVNERDKDKIIDFVKDPKEPPPPPAPEPSWEEVDSDVIHLNEENFKPTLKKRKHALIMFYAPWCGHCKKAKPEFMAAAAKFRDDGKVMFGAVDCTTQQGICSAHDVTGYPTFKYFNY-NKNSQKYMGGREENDFVNFMRDPLSPSP-SPPTA----STKPEEDWADIPGKDFIGFLTKDTFDSFVLSQGSVLVMFYAPWCGHCKRMKPAFGQAASVIVEEKLGALAAVDATIEQQLADRFEIRGYPTLKYFKGGKYAFEYSGGRTADDFIAFLRNP--------------------DAPPTTPSPEPQWSDIV---SDVHHLTDTSFDEFIAANKKTLVMFYSPGCGHCKKMKPDYMTAATRLKEKVPDARLAAVDATRFKDLARKYHIKGYPTLKYFEDGALKADYKSGRSAEDLVEFFSTA----------------------------------------------------------------------------------------------------------------------SDKKDEL K_0010_438 ------------------------------------------------------------------------------------MRGKATMAYINCGDDKKLCKKLKVYTTTFELKHYKDGEFNKNYDRKLTVKSMVNFLMDPTGDIPWDEDLTATDVVHIDTEDGLNKLLKKDKSAALVMFYAPWCGYCKRLKPDFAAAATEVKGKANLVGIDVDKPHMMGLRTLYNITGFPTLYYFEKGKVKYRFGGENSKEGIVSWLSNPKPPEEPKKEAEWAEEPSEVVHLEDDNFDDYIKEHPSVLVMFYAPWCGHCKKMKPGYTEAAQLIKDQEIPSVLAAVDATKHRKLAETYNIKGFPTLKYFKEGEFAFDVNERDKDKIIDFVKDPKEPPPPPAPEPSWEEVDSDVIHLNEENFKPTLKKRKHALIMFYAPWCGHCKKAKPEFMAAAAKFRDDGKVMFGAVDCTTQQGICSAHDVTGYPTFKYFNY-NKNSQKYMGGREENDFVNFMRDPLSPSP-SPPTA----STKPEEDWADIPGKDLIGFLTKDTFDSFVLSQGSVLVMFYAPWCGHCKRMKPAFGQAASVIVEEKLGALAAVDATIEQQLADRFEIRGYPTLKYFKGGKYAFEYSGGRTADDFIAFLRNP--------------------DAPPTTPSPEPQWSDIV---SDVHHLTDTSFDEFIAANKKTLVMFYSPGCGHCKKMKPDYMTAATRLKEKVPDARLAAVDATRFKDLARKYHIKGYPTLKYFEDGAFKADYKSGRSAEDLVEFFSTA----------------------------------------------------------------------------------------------------------------------SDKKDEL magusQFQ61184 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MMGLRTLYNITGFPTLYYFEKGKVKYRYGGENSKEGIVSWLSNPKPPEEPKKEAEWAEEPSEVVHLEDDNFDDYIKEHPSVLVMFYAPWCGHCKKMKPGYTEAAQLIKDQEIPSVLAAVDATKHRKLAETYNIKGFPTLKYFKDGEFAFDVNERDKDKIIDFVKDPKEPPPPPAPEPSWEEVDSDVIHLNEENFKPTLKKRKHALIMFYAPWCGHCKKAKPEFMAAAAKFRDDGKVMFGAVDCTTQQGICSAHDVTGYPTFKYFNY-NKNSQKYMGGREENDFVNFMRDPLSPSP-SPPTA----STKPEEDWADIPGKDLIGFLTKDTFDDFILSQGSVLVMFYAPWCGHCKRMKPAFGQAASVIVEEKLGALAAVDATIEQQLADRFEIRGYPTLKYFRGGKYAFEYSGGRTADDFIAFLRNP--------------------DAPPTTPSPEPQWSDIV---SDVHHLTDTSFDEFIAANKKTLVMFYSPGCGHCKKMKPDYMTAATRLKEKVPDARLAAVDATRFKDLARKYHIKGYPTLKYFEDGAFKADYKSGRSAEDLVEFFSTA----------------------------------------------------------------------------------------------------------------------SDKKDEL PomaceaXP_025081188 --------MAHCIGGVLLASFIFLFLIPFHSGAKQSKKDLVIRVEDFKDFKKLLRTRTNLLVIFAQSEKSASKSMTLFEQVAEEMKGKATIAFVNCGDDKKFCKKLKINPDTFELKHYKDGEFNKDYDRKLAAKSMVNFLMDPTGDIPWDEDPTAVDVIHIDSEDGLNKLLKKDKAATLVMFYAPWCGYCKRLKPEFAAAATEVKGKAQLVGIDVDKPQMMGMRTQYNVTGFPTLYYFEKGRAMFRYGGENNKDGIITWLNNPRPPEEPKKEAEWSEEPSEVVHLEDSNFDTYIKEHSSVLVMFYAPWCGHCKKMKPDYTEAAETIKSEGLTSVLAAVDATKNRKLAEDYKIKGFPTLKYFKDGEYAFEVNERDKDKIIEFIKNPQEPPPPPAPEPSWEEIESSVVHLNEENFKFTLKKRKHSLVMFYAPWCGHCKKAKPEFMSAAAQFKDDSKVLFGAVDCTTQQSICTAHDVTGYPTFKYFNYLNKNSQKYMGGREENDFVNFMRDPLSPSPTLPPATQPQPQTNPGEDWADIEGQKNINFLTAETFDSFIAEQPSVLVMFYAPWCGHCKKMKPAYGEAATKVKEEGLGALAAVDATIEKDLSQKYDIRGFPTLKYFRNGKVEFEYGSGRSASD-IISFM----------------------KDPKASPPPEPEWSEQV---SDVNHLTNDNFDSFLAANRKVLVMFYAPWCGHCKKMKPAYMSAATRLMTEVPDAKLAAVDATKYRELANTYSIKGFPTLKYFEGGKEISDYGGGRSEEDLVNFFKGSKPPTPEESLPSFFHSKWVPSLSGANFSSTLRNREAALVFFYADSCPKCTKYWPEFAAAGEALVNQLATVNCDTYSDLCGLEGIRKFPTFVLYMQGQRKDEYRDAKTKDAFLNYVKTQTPLTKEEL CrassostreaXP_022325952 ------MWHARKKMKFSVLWLAIVSTLPFYLGAKQNSIQEIDDLKDFKKYIKTKP---NVLVVFAKNSKALSQYRQTFSDVSQEMKGKASLIIVDCSEAKKLCKNLKVNPTSIELKHYKGGNFNKDYDRKMVTKSMVNFLLDPTGDIPWEEESGAEDVVHVESPKAFSKMLKKQKQPMLVMFYAPWCGFCKRLKPDFAAAATALKGEAILAGIDVDKPHQMELRQEYNITGFPTLYYFENGKKKFSYGGENNKDGILSWMKDPKPPQPKEEEKPWSAEPSNVVHLTDDNFSTVLAENPSVLIMFYAPWCGHCKTMKPEYTKAAEAMKEQNIAGVLAAVDATKEKKIGDQFKITGFPTVKYFKDGEFAFDFSERTEDKIVEFMKNPSEPPPPPAPEQNWADVPSDVVHLTDENYKPFLRKKKHALIMFYAPWCGHCKKAKPEFQNAAAKLVDDQKVAFCAVDCTVYQNLCTQNDVTGYPTLKYFNY-GKNPQNYMGGREEADFVKFMKDPSNPGATPPPPP----SDPPEKQWADVKGMENLHFLSASNFDTFLQDHKSALVMFYAPWCGHCKAMKPAYGEAASILKEEKIDGVLAAVDATAEPALGNRYNVRGYPTLKYFKNGQEAFDYQSGRSTKDLVSFM----------------------KDPKEPPPPPAPEPAWSTVPSKVNHLTSKDFQSFLKSKASVLVMFYAPWCGHCKKAKPDFQAAADKLAKETTTKVFAAVDCTTNQDICKTEKIDGYPTIKLYSDGIFMSDYNEDRKTDNFYNFLKNA----------------------------------------------------------------------------------------------------------------------PVVKEEL AplysiaXP_005094049 -MAAPMEKTIL--VFISIFVLLLMVPYYSHAQNKKNHKSLIIRVEDFKEFKKLLRTKTNLLVICAESEKATAKVMKLFDEVAQEMKGKATLAYVNCGEDKKFCKKLKFSPTAYDLRHYKDGEFNKEYDRKLAVKSMVNFLLDPTGDLPWEEDPTANDVVHISSEEGFNKLLKKTKNPILVMFYAPWCGFCKRLKPDYSGAATELKNKYTLVGVDVDKPPMMSLRMQYNITGFPTLIYFEKGKVKYKYGGENNKAGIVSWMKDPQPPKEPEKEAEWADEKSEVVHLTDSSFEEFVKQNPSVLVMFYAPWCGHCKKMKPGYTEAAQQLKDEGITGILAAVDATKEKKIAQDNGVKGFPTVRYFKDGEYAFEVNERDKDKIIEFMKDPKEPPPPPPPEPKWEEVESEVVHLTDDSFKGFLKKKKHCLIMFYAPWCGHCKKAKPEFMSAAEKFKEDTKVAFAAVDCTSQTGSCSSNDVTGYPTFKYFNY-GKNSQKYMGGRNENDFVAFMNDPLNPAPTPAPPA----VQSMDEQWRDFAGYESLALLSASNFELVVAESSQLLVMFYAPWCGHCKKMKPAYAEAAAIVEREGLGTLGAVDVTVDGDLGSQYNVKGFPTLKFFKNGQVT--DYNSGRSQELLVKFMRSQASVASEKVEDEEDAAEALDMAPKQRGIEEPRPSAFVPSRS-VQGLVQANFSQYLNDKQAALVMFYDPDCQYCNQAKPHFMKVAKTLQNK--QRGFGSVDCTQEKGLCELEKVTGYPTFKLYVGGKFLSRFAETPNAQTMIRFVENA-------------------------------------------------------------------------------------------------------PVAVEPTPDEKPSGSRRSKEDL BiomphalariaXP_013086306 MMPSTLLKMPVFNICIMTFVFLLLVPCYLDAQKNKNRKSLIIRIDDVKEFKKVLRTKTNLLVICSQSEKATAKVSHIFEEVAEEMKGKATLAYINCGDDKKVCKQLKVTPTTFDLRHYKDGEYNKDYDRKLAVKSMVNFLLDPTGDLPWEEDPTAVDVVHITSEDSFSKLLKRDKNPLLVMFYAPWCGYCKRLKPEFAAAASEVKNDATLVGIDVDKPHMMHLRLQYNITGFPTLYYFENGHLKFKYGGENNKAGIISWLRNPQESKEKETEVEWADENSNVFHLTDLTFNEFIKQNPSVLVMFYAPWCGHCKQMKPGYTEAAQFLKDEEIPGVLAAVDATKEKKIALENNIKGFPTIRYFRNGEFAFEVNERDKDKIIEFMKDPKEPPPPPPQEMKWEEIESDIVHLTDDTFKQFLKKKKHCLVMFYAPWCGHCKKSKPEYMAAATVYKEDPKVAFAAVDCTVHTGTCNSHDVKGYPTFKYFNY-GKNAQKYMGGRE-----------------------------------------------------------------VWCGHCKQMKPDFAEAAEIVKKEGLGTLGVVDATIEKELADKFNIKGFPTLKLFTDGH-EIEYSSGRAKEDLVQYMIQSLY---------------GEEAAESLISKKNSSKNEEKHFLPSHYVHKLTTEIYKQFIKEKAAVFVMFYKPDLVLCQTVKPHFLKAAKTPYAH--NNYFAAVDCTQEEALCAMENILTYPSFYLYFDGTLHKKFIGAHHYATMVNFINFE----------------------------------------------------------------------------------------------------------QKSTSKGTLENIRKDREDL LottiaXP_009066332 ------------------------IPCYLQA--NKKKTDLIIKVDDFKDFKKLLKTKTNLLVIYAQSDKSVSQSWSIFQNVANEIRGKGTLAFINCGEEKKLCKKLKVSPTTFDIKHYKDGEFNKDYDRKISLKSMLNFLLDPTGDLPWEEDPTAQDVVHIDTEGGLAKQLKKNKSPHLVMFYAPWCGYCKRLKPDYSAAATEMKGQAVLVGIDVDKPQLMSLRTQYNITGFPTLYYFENGKLKYPFGGENNKDGIVSWLKNPGPPKEPEKEAEWSDEESDVVHLTDENFQESLDKESSALVMFYAPWCGHCKQMKPGYTEAAATLKSDNIPGILAAVDATKHRKVAEEFKVKGFPSVKYFVNGKYEYDFNERSKEKIMEFMKDPKEPPPPPPPEPKWEETESDVIHLTEDNFKPTLKKKKHALVMFYAPWCGHCKKAKPEYMAAASKLKKDNKVALTAVDCTTQSGVCSAHDVSGYPTFKYFNY-GKNPQVYMGGRVEADFISFMKDPLNPNPGS---QQAEKAADPKDDWKEITGYE------NSFNDYIKNNKN-VLVMFYAPWCGHCKNAKPEYQSAADSILPASENKMAAVDCTEHKEICGKEDVKGYPTIKFYQNGQFSKKFSGSRNKQGFLDFFK-----------------QEEKAADSQTDKKDSKKKDSKK-KDSK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KKDSKKDKDSKKDKDSKKDKDSKKDKKKGKKDKEEL [Protein Disulfide Isomerase (PDI-A6)] /-----------------------------------Thioredoxin (YbbN) domain------------------------------------/ /-------------------------------------Thioredoxin (YbbN) domain--------------------------------------/ /--------------------------------------------------------P5C domain--------------------------------------------------------------/ A_0055_261 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MPPFILSWPIDMGFEDTQPSRRSRQAKK-DGEAEDYDGGRTASDIVQWAMEKAAANIPAPDVYEITSGEVLTDNCEGHQLCIVSVLPQIYDCQSECRNNYISILKTLGEKFKKYQWGWLWAEAGAQPALEQSLEVGGFGYPALAAVNTRKMKFSLLRGQFSEKGINEFLRDLSYGKGSTSPLRNAELPKIEAREPWDGKDAELPVEEDIDLSDVDLD-D-----KDEL A_0039_308 ------GLVALL----TLVTGSLALYEAGKDDVIQLSNSNFHFRVTNSFDIWIVEFYASWCAHCQALVPEWKRVATVLKGIVRVAAINAEEHQSVSGSYNLKGVPAIKLFGTDKQKPVDYEGPRVAKDIIDFCMKYVKDTVDSRYQGRAKK------NKKSKTVNPADLVEVTDSTFNKEVLQHKGMVMLEFYAPWCQHCQNLAPHWKQAATDLKGKVKMCAIDATKNTVTAQKYKVEGFPRIISFM---S-GVRGEDYNGGHTASDIVEWALEKSGADLVSPEVLQITSEEVVKESCEEHQLCIISILPQIYDCQSKCRKNYLGILKRLGEKYKKYQWGWLWAEAGVQPALEDSVEVGGFGYPVLVAVNSRKMKFSLLKGQFSEIGINEFLRDLSFGKGSTAPLRSAALPKIEKTDPWDGKDAQIPVEEDIDLSDVELEDLS----KNEL A_0055_327 --MR--GLVALL----TLVTGSLALYEAGKDDVIQLSNSNFHFRVTNSFDIWIVEFYAPWCAHCQALVPEWKRVATVLKGIVRVAAINAEEHQSVSGSYNLKGVPAIKLFGTDKQKPVDYEGPRVAKDIIDFCMKYVKDTVDSRYQGRAKK------NKKSKTVNPADLVEVTDSTFNKEVLQHKGMVMLEFYAPWCQHCQNLAPHWKQAATDLKGKVKMCAIDATKNTVTAQKYKVE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- A_1387_353 --MR--GLVALL----TLVTGSLALYEAGKDDVIQLSNSNFHFRVTNSFDIWIVEFYAPWCAHCQALVPEWKRVATVLKGIVRVAAINAEEHQSVSGSYNLKGVPAIKLFGTDKQKPVDYEGPRVAKDIIDFCMKYVKDTVDSRYQGRAKK------NKKSKTVNPADLVEVTDSTFNKEVLQHKGMVMLEFYAPWCQHCQNLAPHWKQAATDLKGKVKMCAIDATKNTVTAQKYKVEGFPRIISFM---S-GVRGEDYNGGHTASDIVEWALEKSGADLVSPEVLQITSEEVVKESCEEHQLCIISILPQIYDCQSKCRKNYLGVLKRLGEKYKKYQWGWLWAEAGVQPALEDSVEVGGFGYPVLVAVNSRKMKFSLLKGQFSEIGINEFLRDLSFGKGSTAPLRSAALPKIEKTDPWDGKDAQIPVEEDIDLSDVELEDLS----KNEL V_CG13_308 --MTGTGLVLF-----SLAVAGVSAMYSPSDDVVDLTPTNFHSKVINGDELWIVEFYAPWCGHCQSLAPEWKKAASALKGIVKVGAVNADEHNALGGQYGVRGFPTIKFFGLDKFKPQDYQGQRTAQGIVDFSLNQAKSVASARLSGKKSGDSKSKSGGSGKAGDPADVVELTDSNFEKEVLEHDGLVMVEFYAPWCGHCKNLAPQWAKAASELKGKVKLCALDATVHTVMANRYGVRGYPTIKTFPAGKK-DGEAEDYDGGRTASDIVQWAMEKAAANIPAPDVYEITSGEVLTDNCEGHQLCIVSVLPQIYDCQSECRNNYISILKTLGEKFKKNQWGWLWAEAGAQPVLEQSLEVGGFGYPALAAVNTRKMKFSLLRGQFSEKGINEFLRDLSYGKGSTSPLRNAELPKIEAREPWDGKDAELPVEEDIDLSDVDLD-D-----KDEL V_1302_265 --MTGTGLVLF-----SLAVAGVSAMYSPSDDVVDLTPTNFHSKVINGDELWIVEFYAPWCGHCQSLAPEWKKAASALKGIVKVGAVNADEHNALGGQYGVRGFPTIKFFGLDKFKPQDYQGQRTAQGIVDFSLNQAKSVASARLSGKKSGDSKSKSGGSGKAGDPADVVELTDSNFEKEVLEHDGLVMVEFYAPWCGHCKNLAPQWAKAASELKGKVKLCALDATVHTVMANRYGVRGYPTIKTFPAGKK-DGEAEDYDGGRTASDIVQWAMEKAAANIPAPDVYEITSGEVLTDNCEGHQLCIVSVLPQIYDCQSECRNNYISILKTLGEKFKKNQWGWLWAEAGAQPVLEQSLEVGGFGYPALAAVNTRKMKFSLLRGQFSEKGINEFLRDLSYGKGSTSPLRNAELPKIEAREPWDGKDAELPVEEDIDLSDVDLD-D-----KDEL V_1278_152 --MTGTGLVLF-----SLAVAGVSAMYSPSDDVVDLTPTNFHSKVINGDELWIVEFYAPWCGHCQSLAPEWKKAASALKGIVKVGAVNADEHNALGGQYGVRGFPTIKFFGLDKFKPQDYQGQRTAQGIVDFSLNQAKSVASARLSGKKSGDSKSKSGGSGKAGDPADVVELTDSNFEKEVLEHDGLVMVEFYAPWCGHCKNLAPQWAKAASELKGKVKLCALDATVHTVMANRYGVRGYPTIKTFPAGKK-DGEAEDYDGGRTASDIVQWAMEKAAANIPAPDVYEITSGEVLTDNCEGHQLCIVSVLPQIYDCQSECRNNYISILKTLGEKFKKNQWGWLWAEAGAQPVLEQSLEVGGFGYPALAAVNTRKMKFSLLRGQFSEKGINEFLRDLSYGKGSTSPLRNAELPKIEAREPWDGKDAELPVEEDIDLSDVDLD-D-----KDEL V_1258_205 --MTGTGLVLF-----SLAVAGVSAMYSPSDDVVDLTPTNFHSKVINGDELWIVEFYAPWCGHCQSLAPEWKKAASALKGIVKVGAVNADEHNALGGQYGVRGFPTIKFFGLDKFKPQDYQGQRTAQGIVDFSLNQAKSVASARLSGKKSGDSKSKSGGSGKAGDPADVVELTDSNFEKEVLEHDGLVMVEFYAPWCGHCKNLAPQWAKAASELKGKVKLCALDATVHTVMANRYGVRGYPTIKTFPAGKK-DGEAEDYDGGRTASDIVQWAMEKAAANIPAPDVYEITSGEVLTDNCEGHQLCIVSVLPQIYDCQSECRNNYISILKTLGEKFKKNQWGWLWAEAGAQPVLEQSLEVGGFGYPALAAVNTRKMKFSLLRGQFSEKGINEFLRDLSYGKGSTSPLRNAELPKIEAREPWDGKDAELPVEEDIDLSDVDLD-D-----KDEL A_0875_156 --MTGTGLVLF-----SLAVAGVSAMYSPSDDVVDLTPTNFHSKVINGDELWIVEFYAPWCGHCQSLAPEWKKAASALKGIVKVGAVNADEHNALGGQYGVRGFPTIKFFGLDKFKPQDYQGQRTAQGIVDFSLNQAKSVASARLSGKKSG--KSKSGGSGKAGDPADVVELTDSNFEKEVLEHDGLVMVEFYAPWCGHCKNLAPQWAKAASELKGKVKLCALDATVHTVMANRYGVRGYPTIKTFPAGKK-DGEAEDYDGGRTASDIVQWAMEKAAANIPAPDVYEITSGEVLTDNCEGHQLCIVSVLPQIYDCQSECRNNYISILKTLGEKFKKYQWGWLWAEAGAQPALEQSLEVGGFGYPALAAVNTRKMKFSLLRGQFSEKGINEFLRDLSYGKGSTSPLRNAELPKIEAREPWDGKDAELPVEEDIDLSDVDLD-D-----KDEL A_0855_172 --MTGTGLVLF-----SLAVAGVSAMYSPSDDVVDLTPTNFHSKVINGDELWIVEFYAPWCGHCQSLAPEWKKAASALKGIVKVGAVNADEHNALGGQYGVRGFPTIKFFGLDKFKPQDYQGQRTAQGIVDFSLNQAKSVASARLSGKKSG--KSKSGGSGKAGDPADVVELTDSNFEKEVLEHDGLVMVEFYAPWCGHCKNLAPQWAKAASELKGKVKLCALDATVHTVMANRYGVRGYPTIKTFPAGKK-DGEAEDYDGGRTASDIVQWAMEKAAANIPAPDVYEITSGEVLTDNCEGHQLCIVSVLPQIYDCQSECRNNYISILKTLGEKFKKYQWGWLWAEAGAQPALEQSLEVGGFGYPALAAVNTRKMKFSLLRGQFSEKGINEFLRDLSYGKGSTSPLRNAELPKIEAREPWDGKDAELPVEEDIDLSDVDLD-D-----KDEL A_0055_262 --MTGTGLVLF-----SLAVAGVSAMYSPSDDVVDLTPTNFHSKVINGDELWIVEFYAPWCGHCQSLAPEWKKAASALKGIVKVGAVNADEHNTLGGQYGVRGFPTIKFFGLDKFKPQDYQGQRTAQGIVDFSLNQAKSVASARLSGKKSG--KSKSGGSGKAGDPADVVELTDSNFEKEVLEHDGLVMVEFYAPWCGHCKNLAPQWAKAASELKGKVKLCALDATVHTVMANRYGVRGYPTIKTFPAGKK-DGEAEDYDGGRTASDIVQWAMEKAAANIPAPDVYEITSGEVLTDNCEGHQLCIVSVLPQIYDCQSECRNNYISILKTLGEKFKKYQWGWLWAEAGAQPALEQSLEVGGFGYPALAAVNTRKMKFSLLRGQFSEKGINEFLRDLSYGKGSTSPLRNAELPKIEAREPWDGKDAELPVEEDIDLSDVDLD-D-----KDEL A_0885_174 --MTGTGLVLF-----SLAVAGVSAMYSPSDDVVDLTPTNFHSKVINGDELWIVEFYAPWCGHCQSLAPEWKKAASALKGVVKVGAVNADEHKTLGGQYGVQGFPTIKFFGLDKFKPQDYQGQRTAQGIVDFSLNQAKSVASARLSGKKSG--KSKSGGSGKAGDPADVVELTDSNFEKEVLEHDGLVMVEFYAPWCGHCKNLAPQWAKAASELKGKVKLCALDATVHTVMANRYGVRGYPTIKTFPAGKK-DGEAEDYDGGRTASDIVQWAMEKAAANIPAPDVYEITSGEVLTDNCEGHQLCIVSVLPQIYDCQSECRNNYISILKTLGEKFKKYQWGWLWAEAGAQPALEQSLEVGGFGYPALAAVNTRKMKFSLLRGQFSEKGINEFLRDLSYGKGSTSPLRNAELPKIEAREPWDGKDAELPVEEDIDLSDVDLD-D-----KDEL A_0055_263 --MTGTGLVLF-----SLAVAGVSAMYSPSDDVVDLTPTNFHSKVINGDELWIVEFYAPWCGHCQSLAPEWKKAASALKGIVKVGAVNADEHNTLGGQYGVRGFPTIKFFGLDKFKPQDYQGQRTAQGIVDFSLNQAKSVASARLSGKKSG--KSKSGGSGKAGDPADVVELTDSNFEKEVLEHDGLVMVEFYAPWCGHCKNLAPQWAKAASELKGKVKLCALDATVHTVMANRYGVRGYPTIKTFPAGKK-RRRG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- A_1387_128 --MTGTGLVLF-----SLAVAGVSAMYSPSDDVVDLTPTNFHSKVINGDELWIVEFYAPWCGHCQSLAPEWKKAASALKGIVKVGAVNADEHNTLGEQYGVRGFPTIKFFGLDKFKPQDYQGQRTAQGIVDFSLNQAKSVASARLSGKKSG--KSKSGGSGKAGDPADVVELTDSNFEKEVLEHDGLVMVEFYAPWCGHCKNLAPQWAKAASELKGKVKLCALDATVHTVMANRYGVRGYPTIKTFPAGKK-DGEAEDYDGGRTASDIVQWAMEKAAANIPAPDVYEITSGEVLTDNCEGHQLCIVSVLPQIYDCQSECRNNYISILKTLGEKFKKYQWGWLWAEAGAQPALEQSLEVGGFGYPALAAVNTRKMKFSLLRGQFSEKGINEFLRDLSYGKGSTSPLRNAELPKIEAREPWDGKDAELPVEEDIDLSDVDLD-D-----KDEL A_0239_180 --MTGTGLVLF-----SLAVAGVSAMYSPSDDVVDLTPTNFHSKVINGDELWIVEFYAPWCGHCQSLAPEWKKAASALKGIVKVGAVNADEHNALGGQYGVRGFPTIKFFGLDKFKPQDYQGQRTAQGIVDFSLNQAKSVASARLSGKKSG--KSKSGGSGKAGDPADVVELTDSNFEKEVLEHDGLVMVEFYAPWCGHCKNLAPQWAKAASELKGKVKLCALDATVHTVMANRYGVRGYPTIKTFPAGKK-DGEAEDYDGGRTASDIVQWAMEKAAANIPAPDVYEITSGEVLTDNCESHQLCIVSVLPQIYDCQSECRNNYISILKTLGEKFKKYQWGWLWAEAGAQPALEQSLEVGGFGYPALAAVNTRKMKFSLLRGQFSEKGINEFLRDLSYGKGSTSPLRNAELPKIEAREPWDGKDAELPVEEDIDLSDVDLD-D-----KDEL A_0025_170 --MTGTGLVLF-----SLAVAGVSAMYSPSDDVVDLTPTNFHSKVINGDELWIVEFYAPWCGHCQSLAPEWKKAASALKGIVKVGAVNADEHNTLGGQYGVRGFPTIKFFGLDKFKPQDYQGQRTAQGIVDFSLNQAKSVASARLSGKKSG--KSKSGGSGKAGDPADVVELTDSNFEKEVLEHDGLVMVEFYAPWCGHCKNLAPQWAKAASELKGKVKLCALDATVHTVMANRYGVRGYPTIKTFPAGKK-DGEAEDYDGGRTASDIVQWAMEKAAANIPAPDVYEITSGEVLTDNCEGHQLCIVSVLPQIYDCQSECRNNYISILKTLGEKFKKYQWGWLWAEAGAQPALEQSLEVGGFGYPALAAVNTRKMKFSLLRGQFSEKGINEFLRDLSYGKGSTSPLRNAELPKIEAREPWDGKDAELPVEEDIDLSDVDLD-D-----KDEL A_0520_033 --MTGTGLVLF-----SLVVAGVSAMYSPSDDVVDLTPTNFHSKVINGDELWIVEFYAPWCGHCQSLAPEWKKAASALKGIVKVGAVNADEHNTLGGQYGVRGFPTIKFFGLDKFKPQDYQGQRTAQGIVDFSLNQAKSVASARLSGKKSG--KSKSGGSGKAGDPADVVELTDSNFEKEVLEHDGLVMVEFYAPWCGHCKNLAPQWAKAASELKGKVKLCALDATVHTVMANRYGVRGYPTIKTFPAGKK-DGEAEDYDGGRTASDIVQWAMEKAAANIPAPDVYEITSGEVLTDNCEGHQLCIVSVLPQIYDCQSECRNNYISILKTLGEKFKKYQWGWLWAEAGAQPALEQSLEVGGFGYPALAAVNTRKMKFSLLRGQFSEKGINEFLRDLSYGKGSTSPLRNAELPKIEAHEPWDGKDAELPVEEDIDLSDVDVD-D-----KDEL A_0048_046 --MTGTGLVLF-----SLAVAGVSAMYSPSDDVVDLTPTNFHSKVINGDELWIVEFYAPWCGHCQSLAPEWKKAASALKGIVKVGAVNADEHNTLGGQYGVRGFPTIKFFGLDKFKPQDYQGQRTAQGIVDFSLNQAKSVASARLSGKKSG--KSKSGGSGKAGDPADVVELTDSNFEKEVLEHDGLVMVEFYAPWCGHCKNLAPQWAKAASELKGKVKLCALDATVHTVMANRYGVRGYPTIKTFPAGKK-DGEAEDYDGGRTASDIVQWAMEKAAANIPAPDVYEITSGEVLTDNCEGHQLCIVSVLPQIYDCQSECRNNYISILKTLGEKFKKYQWGWLWAEAGAQPALEQSLEVGGFGYPALAAVNTRKMKFSLLRGQFSEKGINEFLRDLSYGKGSTSPLRNAELPKIEAHEPWDGKDAELPVEEDIDLSDVDVD-D-----KDEL K_0010_017 --MTGTGLVLF-----SLAVAGVSALYSPSDDVVDLTPTNFHSKVINGDELWIVEFYAPWCGHCQSLVPEWKKAASALKGIVKVGAVNADEHNALGGQYGVRGFPTIKFFGLDKFKPQDYQGQRTAQGIVDFSMNQAKSVASARLSGKKSGDSKSKSGGSGKAGDPADVVELTDSNFEKEVLEHDGLVMVEFYAPWCGHCKNLAPQWAKAASELKGKVKLCALDATVHTVMANRYGVRGYPTIKAFPAGKK-DGEAEDYDGGRTASDIVQWAMEKAAANIPSPDVYEITSGEVLTDNCEGHQLCIISVLPQIYDCQSECRNNYISILKTLGEKFKKNQWGWLWAEAGAQPTLEQSLEVGGFGYPALAAVNTRKMKFSLLRGQFSEKGINEFLRDLSYGKGSTSPLRNAELPKIEAREPWDGKDAELPVEEDIDLSDVDLD-D-----KDEL magusQFQ61187 MKMTGTGLVLF-----SLAVAGVSALYSPSDDVVDLTPTNFHSKVINGDELWIVEFYAPWCGHCQSLAPEWKKAASALKGIVKVGAVNADEHNALGGQYGVRGFPTIKFFGLDKFKPQDYQGQRTAQGIVDFSINQAKSVASARLSGKKSGDSKSKSGGSGKAGDPADVVELTDSNFEKEVLEHDGLVMVEFYAPWCGHCKNLAPQWAKAASELKGKVKLCALDATVHTVMANRYGVRGYPTIKAFPAGKK-DGEAEDYDGGRTASDIVQWAMEKAAANIPSPDVYEITSGEVLMDNCEGHQLCIISVLPQIYDCQSECRNNYISILKTLGEKFKKNQWGWLWAEAGAQPALEQSLEVGGFGYPALAAVNTRKMKFSLLRGQFSEKGINEFLRDLSYGKGSTSPLRNAELPKIEACKPWDGKDAELPVEEDIDLSDVDLD-D-----KDEL PomaceaXP_025092026 --MA-GVLLLL-----LTYVAFSFALYSPGDDVIELTPQNFHSKVIEGDELWIIEFYAPWCGHCKALAPEWKKAATALKGIVRVGAVNADEHGGLGSQYGVTGFPTIKFFGEDKFKPTDYSSQRTASAIVDFAISQARSVASSRLSGKKSS--GGSKSSGGNTGDPKDVVEITDSNFEEEVLNYDGMVLVEFYAPWCGHCKNLAPHWAQAATDLKGKVKVCAIDATVNTVMSNRYGIRGFPTIKMFPAGKK-DGEAEDYDGGRTASDIVQWALDKLAENVPPPELKEIVSSTDLQDNCEGRQLCIISVLPQLLDCQSKCRNDYLDILRTLGEKFKKNLWGWLWTEAGAQSELEESLDIGGSGYPALAAVNLKKMKYSPLRGPFSEKGIHEFLRDLSYGKGSTAPLRSAKLPKLNAREPWDGKDAEMPEEEDIDLSDIDFD-DES---KDEL StegodyphusKFM68865 --MYLAVLLIC-----QVLLSFASAFYENNKDITELNPSTFNSQVIESDDIWIVEFYAPWCGHCQALVSEYTKMASALKGLIKVGAVNADQHQSLGQKFEIRGFPTIKIFGANKNRPRDYTGPRTAQGMVDEVFRELKNQVEARLSGKKSS-SKSDDRKSRKEGDPKDVIELTDSNFQETVLDSNEMWLVEFYAPWCGHCQRLAPHWAEAATELKGKVKLGALDATVHTIMARKYDIKGFPTIKYFPQGSK-DGTAEEYDGGRTAQDIINWALEKHAEFTPPPEVVQITDASVLKDACENHPLCVISILPHILDCQSACRNEYIDILKKVGNRYRKNLWGWVWAEALAQPQLEDALGIGGFGYPAMAVLNARKMKFSILRGPFSYDGISEFIRTVSVGRGSSSPIKGAKLPEILETEAWDGKDGELPVEEDIDLSDVDLPEDEPIREKTEL PomaceaXP_025092026 --MA-GVLLLL-----LTYVAFSFALYSPGDDVIELTPQNFHSKVIEGDELWIIEFYAPWCGHCKALAPEWKKAATALKGIVRVGAVNADEHGGLGSQYGVTGFPTIKFFGEDKFKPTDYSSQRTASAIVDFAISQARSVASSRLSGKKSS--GGSKSSGGNTGDPKDVVEITDSNFEEEVLNYDGMVLVEFYAPWCGHCKNLAPHWAQAATDLKGKVKVCAIDATVNTVMSNRYGIRGFPTIKMFPAGKK-DGEAEDYDGGRTASDIVQWALDKLAENVPPPELKEIVSSTDLQDNCEGRQLCIISVLPQLLDCQSKCRNDYLDILRTLGEKFKKNLWGWLWTEAGAQSELEESLDIGGSGYPALAAVNLKKMKYSPLRGPFSEKGIHEFLRDLSYGKGSTAPLRSAKLPKLNAREPWDGKDAEMPEEEDIDLSDIDFD-DES---KDEL LottiaXP_009045951 --MMIGVQVTVCVSIVAVLVTSVASLYSKSDDVVELTPSNFNQKVINGDELWLVEFYAPWCGHCKSLAPEWKKAATALKGVVKIGAVDADEHKSLGGQFGVRGFPTIKIFGANKNSPSDYNGARNAQGIVDSAMSTLKSMVSSRLSGGSGG--GKKSGGGKKAGDPKDVVTLTDSNFEELVIKGKDPWMVEFYAPWCGHCKNLEPHWASAASELKGKVKLGALDATVHTVMAGRYQVKGFPTIKFFPAG-S-NGDAEEYDGGRTSSDIVSWANEKAAANLPPPEVVQIVSESTVTENCEGKQLCVVSILPHILDCQSKCRNAYVKTLKAMGEKFKKHQWGWIWAEAGAQMELEEGLGIGGFGYPAMAAVNIRKKKYSLLKGAFSENGINEFLRDLSFGKGASAPLKSAELPKVVKTEKWDGKDGVLEVEEDIDLSDVELD-D-----KDEL ElysiaRUS88907 --MFGSSLL------VAVVVTSTYALYGPGDDVVVLTPSNFHKTVIESNELWLVEFYAPWCGHCKALTPEWKKAASALKGVVKLGAVDADEHRGLGGQYGVQGFPTIKVFGADKFKPTDYQGPRQAQGIVDSALNAASSMVKSRLSGGKSS--GGGKSSGGGGGNQKDVIELTDANFEKEVLNSEDMWLVEFYAPWCGHCKNLAPHWASAASELKGKVKLGALDATVHTVMAGRYQIQGFPTIKMFPSGKK-GSEVSEYDGGRTSGDIVRWALDKLAENIPPPDVVQLTDPSVLASACDDHQLCIVSVLPHILDCQSKCRNSYLKTLKQMGNKYKKQMWGWVWAEAGQQMELEETLEIGGFGYPALAAVNSRKLKFSLMKGSFSENGINEFLRDLSYGKGSTAPLRNAKLPTVQKIQPWDGKDGVLEVEEDIDLSDVELD-DIDA--KEEL AedesXP_001660597 --M-GTSSIWMVVTLLAGLASSGWALYSSSDDVVELTANNFDRMVVKSDEVWVVEFYASYCGHCRNLVPEYKKAATALKGVIKVGGINCEEEQSLCGQHGVRGYPTIKIFGANKRSPVDYNGQRTAKDIAEAALAEAKKKIKNVLSGG-SS----GSSSDSGSSDSKDVVELTDSNFDKLVLNSDDIWLVEFFAPWCGHCKNLAPHWAKAATELKGKVKLGALDATVHTIKAQQFGIQGYPTIKFFAGGPKDRDSAQEYDGGRTASDIVNWALEKHSENIPAPEIVQLTSEEVTKATCEEKPLCVVSVLPHILDCDAACRNNYLAILAKMGEKYKKKQWGWLWSEGGAQPEIESTLDIGGFGYPAMAVVNVKKMKYSLLRGSFSEEGINEFLRDLSYGRGHTAPVKGAALPKIHNVEPWDGKDGQLPEEEDIDLSDVDLD-E-----KDEL ############################################# [CAP-Superfamily-1] [New Framework] [ /------Signal-------/Pr/ /-C-------------C--------------------------------------------------------C----------------------------------------------------------------------C----C-------C-----------------C------C-------------C-C------C----------C-C-C--------C----C--------C------------C--------C------C---] /--------------------------------------------------------CAP domain----------------------------------------------------------/ A_0039_306 MLSSMQTVGAILMLFIVLVAGRKR QECESKYSDVTPTHTMCLTDNANAVAVTLTQEVKDEIVQMHNEIRVNVTDAANMLKMEWDDRLATVAQKWAMQCVLGHDDYANRVEPDLPGSVGQNVAWSNGDMSFAGAVNMWASEIVDFEYGVWTSITGHYIQQIYAEASRIGCGQSTCGDDKYFVCNYYKSTMGNTSYEQGSPCGQCPSSC---------QGGLCDCTNGPDACFNGGSLNIDTCECQCSGIWGGTDCQEEQCPDEEFMEMCTYPQVVSDPGYWCQFSNFQAGCPILCGDCP--- A_0055_228 MLSSMQTVGAILMLSIVLVAGRKR QECESKYSDVTPTHTMCLTDNANAVAVTLTQEVKDEIVQMHNEIRVNVTDAANMLKMEWDDRLATVAQKWAMQCVLGHDDYANRVEPDLPGSVGQNVAWSNGDMSFAGAVNMWASEIVDFEYGVWTSITGHYIQQIYAEASRIGCGQSTCGDDKYFVCNYYKSTMGNTSYEQGSPCGQCPSSC---------QGGLCDCTNGPDACFNGGSLNIDTCECQCSGIWGGTDCQEEQCPDEEFMEMCTYPQVVSDPGYWCQFSNFQAGCPILCGDCP--- marmoreusA1BQQ5 MLSTMQTVGAILMLSIVFVAGTKR HACDSKYSEVTPTHTMCLTDNANAVAVTLTQEVKVQIVRMHNVIRATVNDAANMMKMEWDDRLAAVAQKWAMQCILGHDGFANHAEPDLPGYVGQNVGWSNYHMTFPDVVDLWAAEIEDYEYGVWNDNTGHYIQQIYAEASRIGCGQSACGEDRYFVCNYYKSTMGNTPYAQGSRCGQCPNSC---------WEELCDCTSGPDACCNGGSLNIDTCECQCPRLWSGADCQEKQCPDHDYEDMCDYPDVVNNPEYWCQFSNIRSDCPIRCGDCP--- textileQ7YT83 MLSTMQTVGAVLMLSIVLVAGRKR HHCDSKYYELTPAHTMCLTDKPNAVAVPLTQETEHEILEMHNKIRADVTDAANMLKMEWDERLA-TVAQKWAMQCILGHDSGRRGEPDLPGSVGQNVAWSSGDLTFLGAVQMWADEIVDFQYGVWTDGTGHYIQQVFAGASRIGCGQSACGNNKYFVCNYYKGTMGDEPYQLGRPCSQCRSSCQHIRGSQGRWGSLCDCTNGPDACFNGGIFNINTCQCECSGIWGGADCQEKHCPNEDFDDMCRYPDALRRPQHWCQYDNFQSDCPILCGYCPNPN [CAP-Superfamily-2] [New Framework] [ /---------/----/-------------------------------------C-------------C---------------------------------------------------------C---------------------------------------------------------------------------C----C------------C------------------C--C---C------C-C----C----------C-C-C--------C------------C-------C------------C---C--C----C----C----------C-C-C--------C----C-------C--------C--------------C---C--C---C--C-----------C-C-C--------C--C--------C---------C--------------C---C--C---------------------------/-------------] /-----------------------------------------------------------CAP domain---------------------------------------------------------------/ /-----------------LC-FACS domain-----------------/ V_1302_222 -----------------------------------------------------CDPKYRSLTPTHTRCAEAFFGASLHLLNQTMKEDIVGYHNELRANVDPPAANMMKMVWDDTLAKTAEKLVMQCYGEHDEMKQRMEPDWPLVDIGQNLGLGHKTFRVMIDRFYTEK--DRLNYQYGQKKYVHGTGHFLQIVAYQSTRIGCAEARCP--NLKSKVFRACNYAPALNTAEPPYKAGKWCSECPDHCDSQGRLCDCRGKLCYN--GGEIDPKTCQCTCPELWMGENCEILNCHSPDPDACRLHSASECGKKNTLTADPNMCPHLCG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- V_CG13_214 --------------MSWHVCVVLILPLLVVV-SSASVKRVYTKDSFPEEGDATCDPKYRSLTPTHTRCAEAFFGASLHPLNQTMKEDIVGYHNELRASVDPPAANMMKMVWDDTLAKTAEKLVMQCYGEHDDMKQRMEPDWPLVDIGQNLGLGHKTFRVMIDRFYTEK--DRLNYQYGQKKYVHGTGHFLQIVAYQSTRIGCAEARCP--NLKSKVFRACNYAPALNTAEPPYKAGKWCSECPDHCDSQGRLCDCRGKLCYN--GGEIDPKTCQCTCPELWMGENCEILNCHSPDPEACRLHSASECGKKNTLTADPNMCPHLCGVCS-DMCGGLQCQNGGWLDPDSCTCKCLGLYTGPTCEH--CPPEDTDYCTYHLPKHHCG------TKVSEKHCPIYCGTCKTHCAPCENFGQM-DATNCKCTCKGHFSGDRCEICPRA-DEAACQSLP--LDYCTSEVSGQASLMNTQCPYRCGVCSHAEKDKDKPVQLTVPQQVRFPPYQSKVGMKDNEYEILLEK A_0885_180 --------------MSWRVCVVLILPLLVVVVSSASVKRAYTKDSFPEEGDATCDPKYRSLTPTHTRCAEAFFGASLHPLNQTMKVDIVGYHNELRANVDPPAANMMKMVWDDTLAKTAEKLVMQCYGEHDDMKQRKEPDWPLVDIGQNLGLGHKTFRVMIDRFYTEK--DRLNYQYGQKKYVHGSGHFLQIVAYQSTRIGCAEARCP--NLKSKVFRACNYAPALNTAEPPYKAGKWCSECPDHCDSQGRLCDCRGKLCYN--GGEIDPKTCQCTCPELWMGENCEILNCHSPDPDACRLHSASECGKKNTLTADPNMCPHLCGVCS-DMCGGLQCQNGGWLDPDSCTCKCLGLYTGPTCEH--CPPEDTDYCTYHLPKHHCG------TKVSEKHCPIYCGTCKTHCAPCENFGQL-DATNCKCTCKGHFSGDRCEICPRA-DEAACQSLP--LDYCTSEVSGQASLMNTQCPYRCGVCSHADKDKDKPVQLTVPEQVRFPPYQSKVGKKDNEYEILLEK A_0039_209 --------------MSWRVCVVLILPLLVVVVSSASVKRAYTKDSFPEEGDATCDPKYRSLTPTHTRCAEAFFGASLHPLNQTMKVDIVGYHNELRANVDPPAANMMKMVWDDTLAKTAEKLVMQCYGEHDDMKQRKEPDWPLVDIGQNLGLGHKTFRVMIDRFYTEK--DRLNYQYGQKKYVHGSGHFLQIVAYQSTRIGCAEARCP--NLKSKVFRACNYAPALNTAEPPYKAGKWCSECPDHCDSQGRLCDCRGKLCYN--GGEIDPKTCQCTCPELWMGENCEILNCHSPDPDACRLHSASECGKKNTLTADPNMCPHLCGVCS-DMCGGLQCQNGGWLDPDSCTCKCLGLYTGPTCEH--CPPEDTDYCTYHLPKHHCG------TKVSEKHCPIYCGTCKTHCAPCENFGQL-DATNCKCTCKGHFSGDRCEICPRA-DEAACQSLP--LDYCTSEVSGQASLMNTQCPYRCGVCSHADKDKDKPVQLTVPEQVRFPPYQSKVGKKDNEYEILLEK A_0031_062 --------------MSWRVCVVLILPLLVVVVSSASVKRAYTKDSFPEEGDATCDPKYRSLTPTHTRCAEAFFGASLHPLNQTMKVDIVGYHNELRANVDPPAANMMKMVWDDTLAKTAEKLVMQCYGEHDDMKQRKEPDWPLVDIGQNLGLGHKTFRVMIDRFYTEK--DRLNYQYGQKKYVRGTGHFLQIVAYQSTRIGCAEARCP--NLKSKVFRACNYAPALNTAEPPYKAGKWCSECPDHCDSQGRLCDCRGKLCNN--GGEIDPKTCQCTCPELWMGENCEILNCHSPDPDACRLHSASECGKKNTLTADPNMCPHLCGVCS-DMCGGLQCQNGGWLDPDSCTCKCLGLYTGPTCEH--CPPEDTDYCTYHLPKHHCG------TKVSEKHCPIYCGTCKTHCAPCENFGQL-DATNCKCTCKGHFSGDRCEICPRA-DEAACQSLP--LDYCTSEVSGQASLMNTQCPYRCDVCSHADKDKDKPVQLTVPEQVRFPPYQSKVGKKDNEYEILLEK A_0239_095 --------------MSWRVCVVLILPLLVVVVSSASVKRAYTKDSFPEEGDATCDPKYRSLTPTHTRCAEAFFGASLHPLNQTMKVDIVGYHNELRANVDPPAANMMKMVWDDTLAKTAEKLVMQCYGEHDDMKQRKEPDWPLVDIGQNLGLGHKTFRVMIDRFYTEK--DRLNYQYGQKKYVHGTGHFLQIVAYQSTRIGCAEARCP--NLKSKVFRACNYAPALNTAEPPYKAGKWCSECPDHCDSQGRLCDCRGKLCHN--GGEIDPKTCQCTCPELWMGENCEILNCHSPDPDACRLHSASECGKKNTLTADPNMCPHLCGVCS-DMCGGLQCQYGGWLDPDSCTCKCLGLYTGPACEH--CPPEDTDYCTYHLPKHHCG------TKVSEKHCPIYCGTCKTHCAPCENFGQL-DATNCKCTCKGHFSGDRCEICPRA-DEAACQSLP--LDYCTSEVSGQASLMNTQCPYRCGVCSHADKDKDKPVQLTVPEQVRFPPSQSKVGKKDNEYEILLEK marmoreusABP48101 --------------MLSTMQTVGAILMLSIVFAAGTKR-------------HACDSKYSDVTPTHTMCLTDNANAVAVTLTQEVKVQIVRMHNVIRATV-NDAANMMKMEWDDRLAAVAQKWAMQCILGHDGFANHAEPDLPG-YVGQNVGWSNYHMTFPDVVDLWAA--EIEDYEYGV--WNDNTGHYIQQIYAEASRIGCGQSAC-----GEDRYFVCNYYESTMGNT-PYAQGS--RCGQCPNSCWEELCDCTSGPDACCNGGSLNIDTCECQCPRLWSGADCQEKQC--PDHDYEDMCDYPDVVNNPEYWCQFSNIRSDCPIRCGDCP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ColubrariaQBH70093 --------------M-MSITLTLTALLLVVPSLMSG----------QAESSPTCDPKYSAMSATHSRCLPPKDEAKLEPLSQETKNEIVRLHNNYRSKIDPPASDMLKLYWDDTLAKTVESLMMQCEGNHDAMGDRMEPDWPNVKIGQNIGMNHKGWQNMLNKFWIEQGIKRLNYTYEG-GYVTGLGHFYQMATARSNRIGCAMVKCKKRDKGTYTYRACNYAPCLNAGDLAYTKGESASLCPDHQTANGTLCDCKDKLCYH--EGVLDVGTCTCQCKGIWTGDNCEKIDCLQGESSSCK---SKDCNEPQTKM----FCPHTCGECT--NCQGVVCNN-GVLNYETCTCECFEGYNGESCDVQVCTEPDNPLCTRIKALGQCDEDGKMTASGKTAYCPMLCGKCKTNCPPCENFGDLTDLNTCACKCKGTFRGERCESCEAARDQFVCGSLKALAGSCDNTASPFYVVLQTDCPLLCGVC----------------------------------------- [CAP-Superfamily-3] [New Framework] [ /------------------/----/----------------------------C-------------C---------------------------------------------------------C-------------------------------------------------------------------------C----C----------C-------------------C--C---C------C-C------C----------C-C-C---------C-------------C---------C-----------C---C--C----C----C----------C-C-C---------C------C----C----------C---C--------C---C--------C-------C--------C---C--C---------------------------------------------] /---------------------------------------------------------CAP domain-------------------------------------------------------------/ V_1278_116 ------------------------------------------------RQSSTCEAKYREYRATHTLCLEDNPKAKAVTLTQAKKDAILNKHNEYRERVDPTATNMRKMVWDDFLARTAKKWVMQCRVAHDDIKDRAEPDWTGVKIGQNLGSGHRSFDAMLDRFYTEKDRLNFTYGD-PYKKGTGHFIQMVDSDAARVGCGQASCPDAAFKVLRACNYAPALDSRRNPYKQG-SPCADCPNHCDSTGKLCEC--GGRLCLNNGRMDVSTCQCKC-QKGRTGDSCQDLDCSVSDLIPACRNGGYTKDDCGKTGPLRDPNFCPHLCRLCD-GPCPGKKCIDGFVLDSNKCECICQGRQVGGR-CESTGGSCPEIKCKHDGVFNKQTCRCYCQGSFTGKACET-CPSEDGSADCQK-------------------------------------------------------------------- A_0885_176 ----------------MTLTAILLCPMLLVTVLGVAAESGSETVRRVRRQSSTCEAKYREYRATHTLCLEDNPKAKAVTLTQAMKDAILNKHNEYRAQVDPTATNMRKMVWDDFLARTAKKLVMQCQVAHDDIKDRAEPDWTGVKIGQNLGSGHRSFDAMLDRFYTEKDRLNFTYGD-PYKKGTGHFIQMVDSDAARVGCGQASCPDAAFKVLRACNYAPALDSRRNPYKQG-SPCADCPNHCDSTGKLCEC--GGRLCLNNGRMDLSTCQCTC-QRGRTGDSCQDVDCSVPDLIPACRNDGYTKDDCGKTGPLRDPNFCPHLCRLCD-GPCPGKKCIDGFVLDTNKCECSCQGRQVGGR-CASTGGSCPEIKCKHDGVFNKQTCRCDCQGSFTGKACET-CPSEDGSADCQKFTKAQCQQQTVRVKCPYMCGVCLPGS------------------------------------------ A_0055_336 MRPQCRWASLTAGSLTMTLTAILLCPMLLVTVLGVAAESGSETVRRVRRQSSTCEAKYREYRATHTLCLEDNPKAKAVTLTQAMKDAILNKHNEYRAQVDPTATNMRKMVWDDFLARTAKKLVMQCQVAHDDIKDRAEPDWTGVKIGQNLGSGHRSFDAMLDRFYTEKDRLNFTYGD-PYKKGTGHFIQMVDSDAARVGCGQASCPDAAFKVLRACNYAPALDSRRNPYKQG-SPCADCPNHCDSTGKLCEC--GGRLCLNNGRMDVSTCQCKC-QKGRTGDSCQDVDCSVPDLIPACRNDGYTKDDCGKTGPLHDPNFCPHLCRLCD-GPCPGKKCIDGFVLDTNKCECSCQGRQVGGR-CASTGGSCPEIKCKHDGVFNKQTCRCDCQGSFTGKACET-CPSEDGSADCQKFTKAECQQQTVRVKCPYMCGVCLPGSATFPRACLHTHGAFLALLLLLSHVVTQLLRHG---------- V_CG13_212 --------------------------------------------------------------------------------------------------VEPTAADMQLLVWDEVLERTAKKWAMQCPLNHD--TNRKEPDWNLLSIGQNIGLGHNTWEIMLDRFFTESTRKNYTYGENFTDDGYGHYYQMVTAQTVRVGCGQAYCPNSDFKRFRVCNYALCMDTSDPPYKNG-TSCSACPDTCSTNYSLCDC--GGKLCLNGGTLNP---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- A_0039_216 MRR----------YVGVVAVLLLLVAIATAASIDRHEKSLGDEVKREKREAATCEKKY-ADLGDHTLCLEDNDDAIQVELNDTMKQHILHLHNYYRCIVEPTAADMQMLVWDEMLERTAKKWAMQCPLNHD--TNRKEPDWNLLSIGQNIGLGHNTWEIMLDRFFTESTRKNYTYGENFTSDGYGHYYQMVTAQTVRVGCGQAYCPNSNFKRFRVCNYALCMDVSDPPYKNG-TSCSACPDTCSTSYSLCDC--GGKLCLNGGTLNPNTCECEC-TEFYVGENCSEHNCAIPD-NVGCQSVSYS--QCGKAGFVKDKAMCPHLCKLCP--ACYGMTCENGGTLNNETCECQCTADYKGEF-CELDCTYC-ENGGD----GDPSTCECDCPSPFYGDLCEIECTMDCNNKGEAVTHDGECMCNCTEGNGGSACEIACTDQAYCSIFASAHYCSPGHFNYMCDTSFAELCPACCHLVTNCPAK A_0031_314 MRR----------YVGVVAVLLLLVAIATAASIDRHEKSLGDEVKREKREAATCEKKY-ADLGDHTLCLEDNDDAIQVELNDTMKQHILHLHNYYRCIVEPTAADMQMLVWDEMLERTAKKWAMQCPLNHD--TNRKEPDWNLLSIGQNIGLGHNTWEIMLDRFFTESTRKNYTYGENFTSDGYGHYYQMVTAQTVRVGCGQAYCPNSDFKRFRVCNYALCMDVSDPPYKNG-TSCSACPDTCSTNYSLCDC--GGKLCLNGGTLNPNTCECEC-TEFYVGENCSEHNCAIPD-NVGCQSVSYS--QCGKAGFVKDKAMCPHLCKLCP--ACYGMTCENGGTLNNETCECQCTADYKGEF-CELNCAYC-ENGGV----GNSSTCECDCPSPFYGDLCEKECTMDCNNKGEAVTHDGECMCNCTEGNGGSACEIACTDQAYCSIFASAHYCSPGHFNYMCDTSFAELCPTCCHLVTNCPAK LottiaXP_009053795 MAK-------------NMVLGQARSDAYGICEKLNSLGFVFDWVLISCSDLHQRFRNLETTPIFCIEDIEFGDINLCLGVTEADKTTIVTLHNQFRAEVKPTASNMLKMKWNNEIAKVAQKWAENCDFVHD--SGSARAIPARYGVGQNLAWGSRSFEAAINLWQDEKEDFTYGADGNDFKK-TGHYTQINWAMSNLVGCGYAKCGTTNYYVCNYAPAGNIGSRFKTPYKQG-EPCADCPDNCDSTGKLCVC---ENTCWHGSNMSVSDCKCDCITESYVTDSCKI-DCNVEDSKTWCGDNGVS---CTKFAKY-----CPNKCKLCP--AADYRNVEKEKAKCDGIKTAPVVLLILLLATLLNIC------------------------------------------------------------------------------------------------------------------- [Proteasome subunit alpha type-4] [Formerly Superfamily R of Lavergne et al. 2013] A_0025_042 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGGWKATCIGNNSANAVSLLKQEYKEGETS-LDEALTLAVKVLSKSLDLTKLTPDKVEMATLTRKDGKTVMSILPDNQVEAL------------------------------- A_0031_005 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGGWKATCIGNNSANAVSLLKQEYKEGETS-LDEALTLAVKVLSKSLDLTKLTPDKVEMATLTRKDGKTVMSILPDNQVEAL------------------------------- A_0039_212 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGGWKATCIGNNSANAVSLLKQEYKEGETS-LDEALTLAVKVLSKSLDLTKLTPDKVEMATLTRKDGKTVMSILPDNQVEAL------------------------------- A_0048_016 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGGWKATCIGNNSANAVSLLKQEYKEGETS-LDEALTLAVKVLSKSLDLTKLTPDKVEMATLTRKDGKTVMSILPDNQVEAL------------------------------- A_0055_229 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGGWKATCIGNNSANAVSLLKQEYKEGETS-LDEALTLAVKVLSKSLDLTKLTPDKVEMATLTRKDGKTVMSILPDNQVEAL------------------------------- A_0239_030 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGGWKATCIGNNSANAVSLLKQEYKEGETS-LDEALTLAVKVLSKSLDLTKLTPDKVEMATLTRKDGKTVMSILPDNQVEAL------------------------------- A_0855_174 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGGWKATCIGNNSANAVSLLKQEYKEGETS-LDEALTLAVKVLSKSLDLTKLTPDKVEMATLTRKDGKTVMSILPDNQVEAL------------------------------- A_0520_027 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGGWKATCIGNNSANAVSLLKQEYKEGETS-LDEALTLAVKVLSKSLDLTKLTPDKVEMATLTRKDGKTVMSILPDNQVEAL------------------------------- A_0875_152 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGGWKATCIGNNSANAVSLLKQEYKEGETS-LDEALTLAVKVLSKSLDLTKLTPDKVEMATLTRKDGKTVMSILPDNQVEAL------------------------------- A_0885_178 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGGWKATCIGNNSANAVSLLKQEYKEGETS-LDEALTLAVKVLSKSLDLTKLTPDKVEMATLTRKDGKTVMSILPDNQVEAL------------------------------- A_1387_011 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGGWKATCIGNNSANAVSLLKQEYKEGETS-LDEALTLAVKVLSKSLDLTKLTPDKVEMATLTRKNGKTVMSILPDNQVEAL------------------------------- V_1258_186 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGGWKATCIGNNSANAVSLLKQEYKEGETT-LDEALTLAVKVLSKSLDLTKLTPDKVEMATLTRKDGKTVMTILPDNQVEAL------------------------------- V_1278_129 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGGWKATCIGNNSANAVSLLKQEYKEGETS-LDEALTLAVKVLSKSLDLTKLTPDKVEMATLTRKDGKTVMTILPDNQVEAL------------------------------- V_1302_232 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGGWKATCIGNNSANAVSLLKQEYKEGETT-LDEALTLAVKVLSKSLDLTKLTPDKVEMATLTRKDGKTVMTILPDNQVEAL------------------------------- magusQFQ61176 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGGWKATCIGNNSANAVSLLKQEYKEGETS-LDEALALAVKVLSKSLDLTKLTPDKVEMATLTRKDGKTVMTILPDNQVEAL------------------------------- marmoreusBAO02223 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RSVPAEAGVQEGETS-LDEALALAVKVLSKSLDLTKLTPDKVEMATLTRKDGKTVMTILPDNQVEAL------------------------------- lenavatiJAI17797 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGGWKATCIGNNSANAVSLLKQEYKEGETS-LDEALSLAVKVLSKSLDLTKLTPDKVEMATLTRKDGKTVMTILPDNQVEAL------------------------------- ermineusAXL95348 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------YGGWKATCIGNNSANAVSLLKQEYKEGETS-LDEALSLAVKVLSKSLDLTKLTPDKVEMATLTRKDGKTVMTILPDNQVEAL------------------------------- LottiaXP_009059710 -----------------MARRYDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILANDGVLLAAERRNTNKLLDEVSFSEKIYKLYDDMACSVAGITADANVLTHDLRLIAQSFVMSYLYQEPIPCEQIVSSLCDIKQAYTQFGGKRPFGVSLLYMGWDRHYGFQLYQSDPSGNYGGWKATCIGNNSANAVSMLKQEYKEGETN-LQEALALSIKVLSKTLDMTKLTPDKVELATLTRENGKTKIRVLGFPEVDKLITVYNEEQAKIEAEKKKEAEKKKASS----- AplysiaXP_005092365 -----------------MARRYDTRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILAKDGILLAAERRNTNKLLDEVSYSEKIYRLYDDMACSVAGITADANVLTNELRLIAQR--HILQYQEAIPCEQVVSALCDLKQAYTQYGGKRPFGVSILYMGWDKHYGYQLYQSDPSGNYGGWKATCIGNNSANAISLLKQEYKSGDIN-LSASLDLAIKVLSKTLDMTKVTADKVEIATLTRKDNKTVIRILSDSEVEVHIKNFEEEEAKLEAEKKKEADKKKASEKPSDK BiomphalariaXP_013065013 -----------------------------------------MEAIGHAGTCLGIMAQDGILLAAEKRNTNKLLDEVSYSEKIYRLYDDMAISVAGITADANVLTNELRLIAQR--YILQYQEPIPCEQLVSTLCDIKQAYTQFGGKRPFGVSILYMGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSANAISLLKQEYKDEDNFSLSAALDLSIKVLSKTLDMTKVTADKVEIATLTRKDNKTVMRILPDNEVEVHIKKYEEEEARLEAEKKKEAEKKKA-EK-SDK ElysiaRUS72144 MLADVLTKYICEATIVNQARRYDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGIMASDGILLATEKRNTNKLLDEVSYSEKIYRLYDDMACSVAGITADANVLTNELRLIAQR--YILQYQESIPCEQLVSTLCDVKQAYTQFGGKRPFGVSILYMGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSANAISLLKQEYKDDNTINLSAALDLSIKVLAKTLDMTKLTPDK--------------------------------------------------------- [Serine protease HTRA2, mitochondrial-like] /--------------------------------------------------------Trypsin_2 domain----------------------------------------------------------------/ /----------------------------------PDZ_serine_protease domain---------------------------------/ A_0055_227 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GFVVRSDGLVVTNAHVVANKAAVKVRLYDGKELEGWVVAVDPVSDLAAIKIDAKGLPVLKMGRSSELRPGEWVIAMGSPLSLSNTVTCGIVSSVNRGSKELGIRNKDMEYIQTDALINFGNSGGPLVNLDGEVIGINAMKVTPGISFAIPSDYASNFLTKVDEVLKRGQSKKRQWFNLGSDTTRRRFIGITMLTLNH-QLLMELKS-RVPDFPEITGGVLVHKMIIGSPAFHGGLQAGDIITEINKQPIQASADVYRFVEASETLHVVAYRGQRKMTFTIISEEVK A_0031_448 ----------------------------------------------------------------------------------------------------------------------------------------------------------------EKAAPAVVYIELIDRHPFSGRMSPVSNGSGFVVRSDGLVVTNAHVVANKAAVKVRLYDGKELEGWVVAVDPVSDLAAIKIDAKGLPVLKMGRSSELRPGEWVIAMGSPLSLSNTVTCGIVSSVNRGSKELGIRNKDMEYIQTDALINFGNSGGPLVNLDGEVIGINAMKVTPGISFAIPSDYASNFLTKVDEVLKRGQSKKRQWFNLGSDTTRRRFIGITMLTLNH-QLLMELKS-RVPDFPEITGGVLVHKMIIGSPAFHGGLQAGDIITEINKQPIQASADVYRLVEASETLQVVAYRGQRKMTFTIISEEVK A_0239_350 ---------------MALTSSRHSLIR-WLCRHYANQTTVFCRNQSTAVNKNYVSRTLLTCCRRRNFCSRRSFWNTKVRQSGTVYNTRPHLSAGMAIGTVGFVAGFVAYLKNKSSIV--------DYVPTGLGTVSAATVDEGDYSSRLSKRFNFVADVVEKAAPAVVYIELIDRHPFSGRMSPVSNGSGFVVRSDGLVVTNAHVVANKAAVKVRLYDGKELEGWVVAVDPVSDLAAIKIDAKGLPVLKMGRSSELRPGEWVIAMGSPLSLSNTVTCGIVSSVNRGSKELGIRNKDMEYIQTDALINFGNSGGPLVNLDGEVIGINAMKVTPGISFAIPSDYASNFLTKVDEVLKRGQSKKRQWFNLGSDTTRRRFIGITMLTLNH-QLLMELKS-RVPDFPEITGGVLVHKMIIGSPAFHGGLQAGDIITEINKQPIQASADVYRLVEASETLQVVAYRGQRKMTFTIISEEVK A_0025_305 ---------------MALTPSRHSLIR-WLCRHYANQTTVFCRNQSTAVNKNYVSRTLLTCCRRRNFCSRRSFWNTKVRQSGTVYNTRPHLSAGIAIGTVGFIAGFVAYLKNKSSIV--------DYVPTGLGTVSAATVDEGDYSSRLSKRFNFVADVVEKAAPAVVYIELIDRHPFSGRMSPVSNGSGFVVRSDGLVVTNAHVVANKAAVKVRLYDGKELEGWVVAVDPVSDLAAIKIDAKGLPVLKMGRSSELRPGE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- PomaceaXP_025096055 MVKIERVMSPGQGLQPGVKMYAAVLIRSWL-RTLKHYSAQNTPSVLVQQSSIS--------CKNHNWVKR--YTTNKGCASVADKNKYILLASGV-LGTSLLAVGYMSWRSHKKSLIQTENVTKSDYF-SRLTTVSA----ESGINTPLSKRFNFIADVVEKTSPAVVYVEIKERHPFYNRRLATSNGSGFVVREDGLILTNAHVVGSKSSVSVRFQDGRELEGFVMAVDPVSDLAAVQVNAANLPVLTLGKSSELRAGEWVIAMGSPLALSNTVTCGIVSSVHRRSQELGIHHKDMDFIQTDAVINFGNSGGPLVNLDGLVIGINTMKVTPGISFAIPSDRATEFLNKVNDLRKKGVPTARKWFGPDVNSKRKHYIGITMLTLTQ-DLLEELRN-RVPEFPDIASGVFIHKIIISSPAHRSGLHAGDIIVEINGKNVQSSTDIYKAISEGGTLQVTVYRGRKRMEFQVLPEEIT AplysiaXP_005103747 MFARVISQSLVRPLIKPNNAKTLVFDSRGLLSAVEACQPSDSSVITRHFFVTQKQKLTCQVQYPKLIVHLRHFHCSSQVNQLRLGKKNVVFQKIKSNKNSFKGVQHLGWFGAVGAVVSF-----GAYWFLDSLQLHPTGAFSSVVHADSRNKNNFIADVVEKAAPAVVFLEIKGRHPLTGKLVTLSNGSGFVVRSNGIILTNAHVVANKSSVSVKLQDGRVFEGQVTAVDPISDLATVKIPASHLATIPLGISSQIRPGEWVIAMGSPLSLSNTVTCGIVSSVQRASKELGLRNKDMDYIQTDAVINFGNSGGPLVDLEGRAIGINTMKVTTGISFAIPSDYAQKFLSKAEALMKRGQTENGF---L-----KRRFIGITMLTLTESVMRDLKNNVRVPSFPDVDGGVFVYKVIPGSPAHIGGVLAGDIIIEISGSRVKSAADVYDAVEKSEILQVVVIRGQTKKVIPINTQETI BiomphalariaXP_013081789 ---------------MFAFRISRPLPL-VCFQLKGSGLKVDYANKNCNYASLNLSAIKFKLLSYNVHQANNSLSRKYDQKNIAFNRKFVHNSSGTEKTNRTVFFRLTQFSKFAFAGL------LGFGAAYLFDVLGVSGVPKSKVYADSNNKNNFIADVVQKAGPAVVFLEIKGRHPFTGRPVTLSNGSGFIVRSNGIILTNAHVVANKSTVSVKLQDGRVMEGQVTAVDPISDLATVKITANNLPIIPLGTSSTIRPGEWVIAMGSPLSLSNTVTCGIVSSVQRASRELGLRNKDMDYIQTDAVINFGNSGGPLVNLDGQAIGINTMKVTTGISFAIPSDYAIKFLVKAEELMKNGQRENGF---L-----KRRYMGITMLTLTENVMRDLKNNIKMPNFPDVDGGVFVYKVIPGSPAHIGGILAGDIIIDISGTPIKSAADVYDAVEKSDYLKVTLIRGSEKKVIPIDTKQTI [Sodium- and Chloride-dependent glycine/GABA transporter] [formerly Superfamily Cerm 18 in Abalde et al. 2018 GBE 10:2643–2662] /----------------Sodium neurotransmitter symporter domain----------/ A_0039_310 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DIELMIGYKPSNYWKVLWCFITPATILFIWSFSVSQLAPVTYGDYQYPTWAIIFGWMLGLCSLLPLPIVMIISIAKEK-GTLWQRVKKLSRPTPSWGPALPENREAYLAS---------------------------------------------------------------------------------------------- A_0875_151 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VNRFYKDIELMIGYKPSNYWKVLWCFITPATILFIWSFSVSQLAPVTYGDYQYPTWAIIFGWMLGLCSLLPLPIVMIISIAKEK-GTLWQRVKKLSRPTPNWGPALPENREAYLASLEPSKRP---AATLELPSPIYSPKKGGASRGASACVLMPEEKKLLSDSATTMSDRSVVGQSTEFTSM---------------LSDGQTLPVSTC A_0855_204 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TMTSAFIDEFPHL-LRNKKVAFTAVMCMIEFLLGIPCVFQGGIYVLQIMDWYCATFSLMLLSFTECVVIAWVYGVNRFYKDIELMIGYKPSNYWKVLWCFITPATILFIWSFSVSQLAPVTYGDYQYPTWAIIFGWMLGLCSLLPLPIVMIISIAKEK-GTLWQRVKKLSRPTPSWGPALPENREAYLASLEPSKRP---AATLELPSPIYSPKKGGASRGASACVLMPEEKKLLSDSATTMSDRSVVGQSTEFTSM---------------LSDGQTLPVSTC A_0055_231 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TMTSAFIDEFPHL-LRNKKVAFTAVMCMIEFLLGIPCVFQGGIYVLQIMDWYCATFSLMLLSFTECVVIAWVYGVNRFYKDIELMIGYKPSNYWKVLWCFITPATILFIWSFSVSQLAPVTYGDYQYPTWAIIFGWMLGLCSLLPLPIVMIISIAKEK-GTLWQRVKKLSRPTPSWGPALPENREAYLASLEPSKRP---AATLELPSPIYSPKKGGASRGASACVLMPEEKKLLSDSATTMSDRSVVGQSTEFTSM---------------LSDGQTLPVSTC V_1278_122 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TMTSAFIDEFPHL-LRNKKVAFTAVMCMIEFLLGIPCVFQGGIYVLQIMDWYCATFSLMLLSFTECVVIAWVYGVNRFYKDIELMIGYKPSNYWKVLWCFITPATILFIWSFSVSQLAPVTYGDYQYPTWAIIFGWMLGLCSLLPLPIVMIISIAKEK-GTLWQRVKKLSRPTPNWGPALPENREAYLASLEPSKRP---AATLELPSPIYSPKKGGASRGASACVLMPEEKKLLSDSATTMSDRSVVGQSTEFTSM---------------LSDGQTLPVSTC A_0885_187 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TMTSAFIDEFPHL-LRNKKVAFTAVMCMIEFLLGIPCVFQGGIYVLQIMDWYCATFSLMLLSFTECVVIAWVYGVNRFYKDIELMIGYKPSNYWKVLWCFITPATILFIWSFSVSQLAPVTYGDYQYPTWAIIFGWMLGLCSLLPLPIVMIISIAKEK-GTLWQRVKKLSRPTPNWGPALPENREAYLASLEPSKRP---AATLELPSPIYSPKKGGASRGASACVLMPEEKKLLSDSATTMSDRSVVGQSTEFTSM---------------LSDGQTLPVSTC V_CG13_236 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TMTSAFIDEFPHL-LRNKKVAFTAVMCMIEFLLGIPCVFQGGIYVLQIMDWYCATFSLMLLSFTECVVIAWVYGVNRFYKDIELMIGYKPSNYWKVLWCFITPATILFIWSFSVSQLAPVTYGDYQYPTWAIIFGWMLGLCSLLPLPIVMIISIAKEK-GTLWQRVKKLSRPTPNWGPALPENREAYLASLEPSKRP---AATLELPSPIYSPKKGGASGGASACVLMPEEKKLLSDSATTMSDRSVVGQSTEFTSM---------------LSDGQTLPVSTC V_1302_229 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TMTSAFIDEFPHL-LRNKKVAFTAVMCMIEFLLGIPCVFQGGIYVLQIMDWYCATFSLMLLSFTECVVIAWVYGVNRFYKDIELMIGYKPSNYWKVLWCFITPATILFIWSFSVSQLAPVTYGDYQYPTWAIIFGWMLGLCSLLPLPIVMIISIAKEK-GTLWQRVKKLSRPTPNWGPALPENREAYLASLEPSKRP---AATLELPSPIYSPKKGGASGGASACVLMPEEKKLLSDSATTMSDRSVVGQSTEFTSM---------------LSDGQTLPVSTC V_1258_172 ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TMTSAFIDEFPHL-LRNKKVAFTAVMCMIEFLLGIPCVFQGGIYVLQIMDWYCATFSLMLLSFTECVVIAWVYGVNRFYKDIELMIGYKPSNYWKVLWCFITPATILFIWSFSVSQLAPVTYGDYQYPTWAIIFGWMLGLCSLLPLPIVMIISIAKEK-GTLWQRVKKLSRPTPNWGPALPENREAYLASLEPSKRP---AATLELPSPIYSPKKGGASGGASACVLMPEEKKLLSDSATTMSDRSVVGQSTEFTSM---------------LSDGQTLPVSTC A_0048_175 -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------K-GTLWQRVKKLSRPTPNWGPALPENREAYLASLEPSKRP---AATLELPSPIYSPKKGGASRGASACVLMPEEKKLLSDSATTMSDRSVVGQSTEFTSM---------------LSDGQTLPVSTC A_0520_121 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DIELMIGYKPSNYWKVLWCFITPATILFIWSFSVSQLAPVTYGDYQYPTWAIIFGWMLGLCSLLPLPIVMIISIAKEK-GTLWQRVKKLSRPTPNWGPALPENREAYLASLEPSKRP---AATLELPSPIYSPKKGGASRGASACVLMPEEKKLLSDSATTMSDRSVVGQSTEFTSM---------------LSDGQTLPVSTC A_0025_127 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DIELMIGYKPSNYWKVLWCFITPATILFIWSFSVSQLAPVTYGDYQYPTWAIIFGWMLGLCSLLPLPIVMIISIAKEK-GTLWQRVKKLSRPTPNWGPALPENREAYLASLEPSKRP---AATLELPSPIYSPKKGGASGGASACVLMPEEKKLLSDSATTMSDRSVVGQSTEFTSM---------------LSDGQTLPVSTC A_1387_038 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DIELMIGYKPSNYWKVLWCFITPATILFIWSFSVSQLAPVTYGDYQYPTWAIIFGWMLGLCSLLPLPIVMIISIAKEK-GTLWQRVKKLSRPTPNWGPALPENREAYLASLEPSKRP---AATLELPSPIYSPKKGGASGGASACVLMPEEKKLLSDSATTMSDRSVVGQSTEFTSM---------------LSDGQTLPVSTC A_0239_057 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DIELMIGYKPSNYWKVLWCFITPATILFIWSFSVSQLAPVTYGDYQYPTWAIIFGWMLGLCSLLPLPIVMIISIAKEK-GTLWQRVKKLSRPTPNWGPALPENREAYLASLEPSKRP---AATLELPSPIYSPKKGGASGGASACVLMPEEKKLLSDSATTMSDRSVVGQSTEFTSM---------------LSDGQTLPVSTC A_0031_251 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DIELMIGYKPSNYWKVLWCFITPATILFIWSFSVSQLAPVTYGDYQYPTWAIIFGWMLGLCSLLPLPIVMIISIAKEK-GTLWQRVKKLSRPTPNWGPALPENREAYLASLEPSKRP---AATLELPSPIYSPKKGGASGGASACVLMPEEKKLLSDSATTMSDRSVVGQSTEFTSM---------------LSDGQTLPVSTC ermineusAXL95651.2 --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VNRFYKDIELMIGYKPSTYWKALWCFITPATILFIWSFSVSQLAPVTYGDYQYPTWAIIFGWMLGLCSLLPLPIVMVISIVKEK-GTLWQRVKKLSRPAPNWGPALPENREAYLASLEPSERP---AATLELPSPIYSPKKGGASGGASACVLMPEEKKLLSDSATTMSDRSVVGQSTEFTSM---------------LSDGQTLPVSTC LottiaXP_009060824 M-------------------------------------------------------KQRENWGGKMDFILTCIGYAVGLGNIWRFPYLCYKSGGGAFFIPYTIFLVLCGIPVFFLEVSYGQFSSLSPVAVWRMSPLFKGIGIGMVLVSSIVCIYYNVIIAWTLYYLVMSFQSVLPWSHCNNDWNTINCIDQQRS----------EMFAELSNSTIGSNMYENFTNTNLSY-------------------FFVNNTL-REPGNIS-ASEEYWTHHVLELSDGIEDLGPIRWQLLIALAMSWVLVFLCLFKGVKVLGKVMHFAAPFPYLVLLVLLIRGVTLPGALEGIKFYIIPRWEKLADFQVWGDAALQIFYSVGMGWGGIVTMASYNKFSHNVYRDSMMVPFINCGTSIFAGFVIFSVLGFMAHEAGVSVDKVVTEGPGLTFVAYPEAISKLPISPLWAVLFFLMLLTIGLDSQFGMFETMLSGAMDEFPKL-FRNRKVIVTLISCFAEFLMGLACITKGGIYVLQVMDWYCASFSLMLISLAECLVIAYVYGTDRFLKDIELMIGYQPPRIWVYMWKYVTPIVIVFIWLFSVITLKPVTYGDYEYPPWAIGLGWSVGLVSLIPIPLCMVVQIYNEK-GPILQRIKKLMKPAANWGPALPEDRKRYLNSLTFTHPEL--AEKMLAAE--------------------PEEKLPLDDTE--LSNSTPMVEKDTFSNV--------------------------- PomaceaXP_025086278 MD--------------------------TDSTNS-------SSVSSSNGLKPTQAQHERGGWGGKLDFILTCIGYAVGLGNIWRFPYLCYKSGGGAFFIPYTMFLLMCGLPLFFMEVSCGQFSSLSPVPIWKICPMFKGVGIGMVMVSSIVCIYYNVIIAWTIYYLFLSFRATLPWSTCKNEWNTQSCLDTSQLFAE-------EMSQNRT-ASNSSTLYALASILEVASPYPDMAANSSEQSAPLAISMAANLTAPSGRKAMS-ASEEFWQHHVLKLSSGIEELGEVRWQLLICLALSWLFVFLCLFKGVKILGKVMHFAAPFPYLVLTVLLIRGVTLPGAIDGIKFYIIPRFEELTKFQVWGDAALQIFYSVGMAWGGVITMASYNRFNNNAYRDAMIVPFVNCGTSVFAGFVIFSVLGFMAHEANSTVDQIVTQGPGLTFVAYPEAVSKMPIAPLWSILFFLMLFVVGLDSQFGMFETMLSSLIDEFPHL-LRGRKTLLTAVTCFVEFLLGIPCICQGGIYVLQTMDWYCSSFSLMIISFVECVAISWIYGMDQFMKDIELMIGFKPCRFWTYMWKFVTPTVVLFIWVFSVTTLGPVTYGSYTYPTWAIIMGWTIGVSSMLPIPIYALYRLTGEK-GSISERVRKLWTPAPDWGPKLPEHRKLYLASRG--------IMNMDSLE--------------------PLKKKSPD------SFKGFVGQM-QHEEV--------------------------- MizuhopectenXP_021359127 MSKCVVPVDSDVV---MTRFITEKEKALETPTDS-------SVVSSCSTVYSGDE-TSRGNWSGRMDFLLSCIGYAVGLGNIWRFPYLCYKSGGGAFLIPYLIFLVLCGIPLFFLEVSYGQFASLSPITVWRICPLFKGVGYGMVIISGIVCIYYNIIITWTIYFLYYSFRAVLPWSTCDNWWNTEKCFLRTKD-HEKNTTL--VTLSNETNSSNTSWSYDVSMATPL---------------------LADNDTKT--------ASEEFWQRAVLQMSDGIDDMGDLRWDLLICLFVAWVIVFLCLFKGVKSSGKVVYVTATFPYLVLLILLVRGVTLPGAGAGIYFYLVPDWNKLATFEVWGDAAVQIFYSVGMAWGGLITMASYNKFHNNVYRDAMVVPLINCGTSVFAGLVIFSVLGFMAHETGVDIEKVVTQGPGLTFVAYPEAVAKLPISPLWAVLFFLMLFTIGLDSQFGMFETMTSAFVDEFPDL-LKNRKELFTAFMCFIEFLLGIPCVMQGGVYVLQIMDWYCSTFSLMILSLTECIVIGWIYGADRFYRDIELMIGYQPCVWWKISWCYITPILILFIWLFSVTQLSPVTYGDYHYPQWAIILGWFLGLISLAPVPICAVILIFKET-GPIMLRVKKLLKPAENFGPAVPKYREEYVETL---------EKRQSYF-------------------------PTIDLRC----RHTGSSEFIQTGETQ-------------NFMS--------- CrassostreaXP_022325413 MKNSEKNADFTV----NGDYLKEKELALMDTESS-------SASSSQSSLEKGDENVGRGNWSGRLDFLLSCIGYAVGLGNIWRFPYLCYQSGGGAFLIPYVIFLVLCGMPLFFLEISYGQFSSLSPIAIWKISPLFKGVGYGMVIISGIVCVYYNIIITWTIYFLYHSFRAVLPWSTCDNSWNTDKCYIRGES-TLTNATATGTIGYNVTQLNTTSLSSVPSVALNLVN-------------------GTSNVTKSDLSNKVT-ASEEFWQNEVLQITEGIEDLGVVRWELLICLAVAWIVVFLCLCKGIKSSGRVVYVTATFPYLVLTILFIRGVTLPGAGAGIYFYLVPEWEKLTTFKVWGDAAVQIFYSVGMAWGGLITMASFNKFNNNCYRDAMIVPLINCGTSVFAGLVIFSVLGFMSYETGVAIDKVVTQGPGLTFVAYPEAVAKLPISPLWAVLFFLMLFTIGLDSQFGMFETMTSAFVDEFPGL-LKNRKMLFTALFCFIEFLLGIPCIMQGGIYVLQIMDWYCATFSLMLLSLTECVVIAWIYGADRFYKDIELMIGYQPGVWWKICWKFITPVTITFIWLFSVTQLSPVTYGDYEYPNGAIVFGWMLGLASLLPVPLCAIIAILREK-GSLVQRIKKLVRHTEDWGPAVEKHRVRYLQTL---------QDSQESLDSVVC-------------------TPLVDAKA-----HTASPQS--------------------------------- OctopusXP_014769620 MTK-----------------VYEEQVVKTIDEESN------SSTSDDSSSISSDENKDRGNWTGRLDFMLSCVGFAVGLGNIWRFPYLCYKSGGGAFLVPYFLFLFLCGIPLVFMETSYGQFASLSPLAAWRISPMFKGVGYGMVIVSGIVCIYYNIILAWTLYYLFYSFREILPWSNCENKWNSKNCAVTERQ-NVTATPNSIVFTTNGTMLTNATSLVGLSNATDLVD-------------------KMTNDDILSNVTKVS-PSEEFWQLKVLDITDGIEDLGIIRWELLLCLLLAWVVVFLCLCKGIKSSGRVVYVTATFPYLVLTILLIRGVTLPGAWEGLKFYLIPKWSRLLDFQVWGDAATQIFYSVGMSWGGLITMASYNKFHNNVYRDAMIIPVIGCTTSVYAGLVIFSVLGFMSYETGIPIEDVVTQGPGLTFVAYPEAVTKLPVSPLWAILFFLMLFTVGLDSQFGMFETMTSAFVDEFPEL-LAKRKVLFTAGICFVEFLLGIPFVTQGGIYLLQVVDWYCSTFSLMILSLTECVVISWIYGADRFYNDITLMIGYKPCVWWKISWRFITPTITLLVWLFSISKLSPVTYGDYTYPTWSIVFGWILGMVSLVPLPAVMISQIFKTK-GTFIERVKKLIHPDPKWGPSLPQYREQYIASLSF-------SERQRMLRHIMENEKDG-----------PHNMSVIG-------EHAKMLQL-QLDSV--------------------------C AplysiaXP_012934684 MTYQMKQDDEKIVVFDTTPTVAASGTAVDDDTDAKKQDLEPSEAGSSVTSIESDDLKERENWTGRLDFLLSCIGFAVGLGNIWRFPYLCYKSGGGAFLVPYIIFLILCGLPLFFMEISYGQFASLSPITVWRISPLFKGIGYGMVIISGIVCVYYNIIITWTFYYLFMSMRKVLPWSVCGQSWNSPDCVVERPVINETEALETTSLFENATFALDNSTSFANSSFVNSSV-------------------IVGNMSALVNKTMFSPASQEFWENNVLEKTSGIEDFGGIRWPLFGCLVLAWTIVFLCLCKGVKSSGKVVYVTATFPYLVLLILLVRGVTLPGAAEGIKFYLIPRWEKLATFKVWGDAAVQIFYSVGMAWGSLITMASYNKFSNNVQRDALIVPILNCSTSIFAGLVIFSVLGFMSHTTGVPIDKVVTQGPGLTFVVYPEAVAKMPLSQLWAILFFLMIFTIGLDSQFGMFETMTSAFIDEYPQL-LRKKKILFTAFMCFIEFVLGIPIVFQGGAYLLQIMDWYCATFSLMLLSFSECMVISWIYGVDRFLKDIELMIGYKPSVFWKIMWKFVTPAVVLFIWLFSVSQLEPVTYGDYEYPTWAITFGWLLGLCSIIPVPILAIHAIYKEETGTLFQRIRKLVEPAANWGPSQMEDKMRYIESMTSFERERFEAAQQNVDRQRYLVMRNMNS---SAIYKGPVTTINLDTAE----ESAVREQMLPAGAANYPFSAPTEPSHLTNLLNGEKPPNSIC CapitellaELU16913 MP-------------------------LLSCCQSKS-----GTEPDRLSEDSGDENMKRGNWSGRLDFLMSCISYAVGLGNIWRFPYLCYRNGGASFLIPYLTFLALCGMPLFFLEVSYGQFASLGPISVWRMSPLFKGIGWGMILISGIVCIYYNIIIAWTLYYLFMSFSPTLPWSTCDNSWNTEQCALKNRSWSEVNAS---SFDDNVTLLAT----------------------------------VATNVSALKRTT----PSEEFWSHHVLKITSGIDDVGGIRWELLGCLALAWFVVFLCLIKGIKSSGKVVYFTATFPYIVLLTLLIRGVTLPGSLEGIKFYVIPQWDKLLSLKVWGEAAMQIFYSIGAGWGALITFASYNKFHNDCYRDARIIPILNSGTSVFAGFVIFSIIGFMAHETGESVENVITEGPGLVFVVYPAAVARLPVSQFWSILFFLMLFSVGIGSQFGMFQTMTSGFSDEFKFLQTPRRKLLLTAALCIFEFLVGIICITEGGIYFFQIIDWYSSTFSLMIISLTETLVIMWIYGAEMFYKDLELMIGYKPCLWWRILWSGVTPAIILFVFIFTAVLHSPVTYGDYEYPSWAIGLGWVFAICSIVPLPGIAIYKMVTTD-GTFLQRLKKLVHAAPEWGPAVPQHREEWLRSHGRTYGNFLEASELEKLNDI------------------KHEEIEADLRQ----EKPPIV----------------------------------- [Thioredoxin domain-containing protein 5] /-----------------------------------Thioredoxin (YbbN) domain------------------------------------/ A_0055_237 ---A-ANTAHVVCLISLFILVCVSCDDDHGSDAVSYERDAFQSAINDKKHFVMFFAPWCGHCKRLAPTWNELAKVYNN-DESSVTIAKVDCTVETALCSEHDVTGYPTLKFFHKKADDFQRYKGNRDLDSLKKFVEEQ----ASRTESEGEQATQAAEPGAGALVELTDDTFEAFIQKGIHFVKFYAPWCGHCKRLAPTWEELARSFAGNQQVSVSKVDCTVSTKLCTSQGVRGYPTLILFNDGDKFEQYQGSRSLEDLTGFVTSKMEEVLGFQQQEAVPEEEQEEAVVDLTAD-----------TFEEAISDGLTFVKFFAPWCGHCKRLAPTWEDLARTNM-DKDIVIARVDCTLHKSV--CDDQKVQGYPTLVLFQNGKRKNDYKGQRDLGSLQEFVDSHVE--HTEL magus DAC80631.1 M--A-ANTAHVVCLITLFILVCVSCDNDHGSDAISYERDAFQSAINDKKHFVMFFAPWCGHCKRLAPTWNELAKVYNN-DESSVTIAKVDCTVETALCSEHDVTGYPTLKFFHKKADDFQRYKGNRDLDSLKKFVEEQ----ASRTEGEGEQATQAEEPGAGALVELTDDTFDAFIQKGFHFVKFYAPWCGHCKRLAPTWEELAKSFAGNQQVSVSKVDCTVSTKLCTSQGVRGYPTLVLFNDGDKLEQYQGSRSLEDLKGFVTNKMEEVLGFQQQEAVPEEEQEEAVVDLTAD-----------TFEEVISDGLTFVKFFAPWCGHCKRLAPTWEDLARTNM-DKDIVIARVDCTLHKSV--CDEQKVQGYPTLVLFQNGKRKNDYKGPRDLESFQEFVDSHVE--HTEL PomaceaXP_025090120 M--ALSYFHVVCLMLSVLSFILPAESDDHGADVVNYDRDTFQSAITDQKHFVMFFAPWCGHCKRLAPTWNELAKIYNN-EESSVTIAKVDCTIETALCSDQDVTGYPTLKFYHKSLDDFVRYKGNRDLDSLQKFVEEQ----VDRTVKDTIVPPVPEEDKDQGPTELTDETFSSVIKQGTHFVKFFAPWCGHCKHLAPTWDDLAKSFAGSKKVTIAKVDCTSSKTVCTDMGVSGYPTLTWFQDGEKVEQYTGGRTHEELKNFVNNKLKELGEASFGQEEE-KVPENLVEEPVRD-------LTDESFESVVAEGLTFVKFFAPWCSHCQRLAPTWEELGAAYS-EKPVTIAKVDCTQHKAV--CDSQNIHGYPSLLIFQNGVRLEEYNGPRSLEDLKKFVDKFLA--HVEL ElysiaRUS88906 MYFSCSAPLVASCLFFSSVLISSRADDGHGSASVSYNQDSFKAGIDAKMNFVMFFAPWCGHCKSLAPTWNELGKIYNKLDDSPVTIAKVDCTEETALCADHEVTGFPTLKLFEKGGKSFKRYSGKRDLESLKNYVQEQ----VVGQDEQAQKGEAASEEKADSLVVLTDDNFVATVASGAFFIKFYAPWCGHCKKLAPTWDELAETYASRKGVSVAKIDCTQSTVICKQYEVRGYPTLLWFQDGDKVAKYQGSRSHEALKEYVDNMLETAAGAKKVEAEEQKTEDEPKQDVEVDVKGDVKDLTEENFKPFLSSRLVFVKFFAPWCGHCKRLAPTWEELAAKVK-GEEVTIAKVDCTQHKSV--CDANQVRGYPTLKIFRNGEHVADYKGSRSLDDLEQFVSQNLNK-RDEL LottiaXP_009055216 M---ADRFVYVLTLCLILCSAQSKADDDHGENVVTLKKDTFNDAVSSSKLFVMFYAPWCGHCKRLGPTWNELATVYNKLENSPVTIAMVDCTDETPLCAEHEITGYPTLKYFHNPT-DFVRYKSGRDIQSLKSFVEEQ----------QQADQEKPEVPEPQKGLLVLDEKFDETIKLGNYFVKFYAPWCGHCKRLAPVWDDLARSFEFVEDVTIAKIDCTQHGSVCSSNAIRGYPTLIFFSNGKEVEKYSGGRDHENLKNFVDKMLNRKPEEKEQESEGKIPEELTDSTYEEV----------------QSSPLAFIKFYAPWCGHCRKLAPTWIDLSKKFSETEEVVIADLDCTQYEEI--CKDNKVRGYPTLLLFRHGILVEEYSRSRTLEDMYDFVHEHIQE-RDEL Penaeus XP_027235670 M--------LVLSFVLGLLAFGGVNCDEHGANAVTFTSDTFEDSVPLKPHFVMFFAPWCGHCKRLSPTWDDLGKKYNSQESTEVVIGKVDCTQHTALCSSQDVTGYPTLKLFAKGVEGGVKYRGPRDLASLERFIAEQ------LGTEVEDDGQAAVPDAHAGLIEFTDATFKTVVATGNHFIKFYAPWCGHCQRLAPTWDILAKTFEHDKSVTIGKLDCTKYREICTEYEVKGYPTLLWIEEGKKMEKYSGDRSHGDLKAFVAKMLGDEAGKKKEDEDADGPRSPVVVLTTEN------------FENAIEQGYTFVKFFAPWCGHCKRMAPTYDELGRKFVGHDKVKIAKVDCTQEINRGLCSQQKVNGFPTLFLYKGGEQISEYTGDRSLDDMVTFVTSHLG--HDEL AplysiaXP_005110685 M---ADTTIVQLLALVVFVVALVSGEDDHGTNTVSYDKKTFEAGIAKGRNFVMFYAPWCGHCKNLAPTWDQLANVYNKKATSPVVIAKVDCTVQTGLCADHEIVGFPTLKLFEAGGESHKRYTGKRDLESLKAFVQDNLQGEEGEAVEQAPEGKPEVPEPKSALVTLTDDTFAEHVAEGGHFVKFYAPWCGHCKKLAPVWEELAETFGHVEDVSIAMIDCTRSQVICKQYEIRGYPTLVWFVDGKQKDKYQGARTHEALKKFVAERMEEGSQEGEEEEDEGEEENADDLVQVAEGKVLDLNQANFKAQLKASS-LIFIKFFAPWCGHCKRLAPTWDELAKHFAD-EEVAIAKVDCTQHKSV--CDDYQVRGYPTLKMFRDGEVVNDYRGPRALEDLSGFVKKYLEENHDEL