Locus Lead SNP A1 MAF Chr Position (BP) Z-value P-value Mapped gene(s) 1 rs13322873 A 0.09 3 190595257 13.27 3.32e-40 2 rs8061569 C 0.46 16 70681184 12.44 1.64e-35 LARS2, LIMD1, SACM1L, SLC6A20 3 rs8014725 G 0.4 14 56186953 11.84 2.53e-32 4 rs11111090 C 0.48 12 102326461 11.34 8.75e-30 DPP4 5 rs72754248 A 0.08 9 119061396 10.73 7.36e-27 PKDCC 6 rs146607495 T 0.1 12 117319202 10.5 8.67e-26 COL3A1, COL5A2, WDR75 7 rs4843555 T 0.44 16 87231160 10.16 3.05e-24 CDC25A, ZNF589, NME6, SPINK8, FBXW12, PLXNB1, CCDC51, TMA7, ATRIP, TREX1, SHISA5, PFKFB4, UCN2, COL7A1, UQCRC1, TMEM89, SLC26A6, CELSR3, NCKIPSD, IP6K2, PRKAR2A, SLC25A20, ARIH2OS, ARIH2, P4HTM, WDR6, DALRD3, NDUFAF3, IMPDH2, QRICH1, QARS, USP19, LAMB2, CCDC71, KLHDC8B, C3orf84, CCDC36, RP11-3B7.1, C3orf62, USP4, GPX1, RHOA, TCTA, AMT, NICN1, DAG1, BSN, APEH, MST1, RNF123, AMIGO3, GMPPB, IP6K1, CDHR4, FAM212A, UBA7, TRAIP, CAMKV, MST1R, CTD-2330K9.3, MON1A, RBM6, RBM5, SEMA3F, GNAT1, GNAI2, LSMEM2, IFRD2, HYAL2, TUSC2, RASSF1, ZMYND10, NPRL2, CYB561D2, XXcos-LUCA11.5, TMEM115, CACNA2D2, CISH, MAPKAPK3, DOCK3 8 rs13107325 T 0.08 4 103188709 10.03 1.15e-23 INTS3, SLC27A3, GATAD2B, DENND4B, CRTC2, SLC39A1, CREB3L4, JTB, RAB13, RPS27, NUP210L, TPM3, C1orf189, C1orf43, UBAP2L, HAX1 9 rs72764483 G 0.26 5 64962816 9.18 4.48e-20 PEAR1, LRRC71, ARHGEF11, ETV3L 10 rs11245347 G 0.44 10 126427037 9.17 4.69e-20 C2orf73 11 rs6658111 G 0.36 1 47980916 9.11 8.52e-20 PRDM16 12 rs12146713 C 0.09 12 106476805 8.94 4.01e-19 NOSTRIN, SPC25 13 rs6897765 G 0.19 5 115922144 8.9 5.84e-19 TAGLN2, IGSF9 14 rs73123652 C 0.08 12 65874956 8.87 7.06e-19 15 rs4775006 A 0.42 15 58215727 8.83 1.03e-18 MARCH4, SMARCAL1, RPL37A 16 rs8104519 C 0.24 19 33560298 8.79 1.51e-18 ADAMTS9 17 rs2817144 C 0.25 1 3132424 8.53 1.51e-17 PRKCZ 18 rs4405620 A 0.4 18 50884529 8.29 1.09e-16 C3orf49, THOC7, ATXN7, PSMD6 19 rs10765544 T 0.37 11 92024284 8.26 1.47e-16 20 rs1479492 C 0.33 12 28308424 8 1.24e-15 21 rs4128399 C 0.16 7 151498679 7.76 8.81e-15 KCNK2 22 rs3770774 C 0.48 2 37192495 7.72 1.15e-14 STIL, CMPK1, FOXE3, FOXD2 23 rs75925257 A 0.11 1 155138842 7.57 3.60e-14 LACTBL1, C1orf234, KDM1A, LUZP1, HTR1D 24 rs2417612 G 0.41 12 16926654 7.53 5.03e-14 NCKAP5 25 rs798510 T 0.28 7 2783338 7.39 1.49e-13 AL162431.1, STX6, MR1, IER5 26 rs6432708 C 0.37 2 162891848 7.32 2.43e-13 DMRTA2, FAF1, CDKN2C 27 rs7861718 C 0.31 9 3924447 7.32 2.47e-13 KCNK3, SLC35F6, CENPA, DPYSL5, MAPRE3, TMEM214, AGBL5, OST4, EMILIN1, KHK, CGREF1, ABHD1, PREB, C2orf53, TCF23 28 rs57263785 G 0.25 9 2197987 7.2 5.90e-13 RDH14, NT5C1B-RDH14, NT5C1B 29 rs10792032 G 0.49 11 68984602 7.06 1.69e-12 BCL11A 30 rs6060983 C 0.33 20 30420924 7 2.48e-12 ROBO2 31 rs1419859 T 0.38 12 4007898 7 2.52e-12 SH3RF3 32 rs6133987 T 0.24 20 10650354 6.91 4.90e-12 FOXP1 33 rs916784 G 0.4 7 117599514 6.84 7.84e-12 SLC45A3, NUCKS1, AC119673.1, RAB7L1, SLC41A1, PM20D1 34 rs2153960 G 0.36 6 108988184 6.84 8.01e-12 POGK, TADA1, ILDR2, MAEL 35 rs6062264 T 0.27 20 61154871 6.84 8.15e-12 36 rs2303040 C 0.43 19 39138608 6.81 9.82e-12 MAGI1 37 rs4380763 G 0.36 6 149999222 6.75 1.45e-11 RALGPS2, ANGPTL1 38 rs11205761 C 0.41 1 51183257 6.68 2.32e-11 CROCC, MFAP2, ATP13A2, SDHB 39 rs73137384 T 0.26 3 89463290 6.62 3.60e-11 DAB1 40 rs12536500 T 0.22 7 50808033 6.62 3.69e-11 C1orf106, KIF21B, CACNA1S 41 rs7686608 C 0.22 4 54754775 6.57 5.18e-11 TBX15, WARS2 42 rs55938743 C 0.3 3 158854255 6.53 6.55e-11 WLS 43 rs76065536 G 0.07 18 38013622 6.48 9.19e-11 CADPS 44 rs2685799 C 0.49 2 169711304 6.39 1.70e-10 CPT2, C1orf123, MAGOH, LRP8 45 rs111820348 T 0.23 16 28645127 6.38 1.75e-10 TBC1D5 46 rs10861645 T 0.35 12 107071130 6.32 2.67e-10 CALCRL, TFPI 47 rs7894565 C 0.33 10 21872913 6.27 3.69e-10 48 rs2974322 T 0.42 8 42424724 6.15 7.63e-10 KIF26B 49 rs4920605 G 0.45 1 17315425 6.14 8.43e-10 50 rs6690450 C 0.49 1 54854079 6.13 9.03e-10 CAPZB, MINOS1-NBL1, MINOS1, NBL1 51 rs2937071 G 0.44 5 15757554 6.12 9.32e-10 KCNN3, DCST2, DCST1, ADAM15, EFNA4, EFNA3, EFNA3, EFNA1, SLC50A1, DPM3, KRTCAP2, RP11-201K10.3, TRIM46, MUC1, THBS3, MTX1, GBA, FAM189B, SCAMP3, CLK2, HCN3, PKLR, FDPS, RUSC1, ASH1L, MSTO1, YY1AP1, DAP3, GON4L, SYT11, RIT1, KIAA0907, RXFP4, ARHGEF2, LMNA 52 rs6444749 C 0.42 3 193546238 6.1 1.03e-09 COL11A1 53 rs11216435 T 0.2 11 117388932 6.06 1.37e-09 POU3F3 54 rs1075472 G 0.18 14 93108131 6 2.01e-09 MAP2 55 rs9428576 C 0.42 1 243662027 5.96 2.55e-09 C1orf210, TIE1, MPL, CDC20, ELOVL1, MED8, SZT2, HYI 56 rs12570727 A 0.42 10 18425519 5.96 2.57e-09 ATP6V1E2, RHOQ, PIGF, CRIPT 57 rs6595162 C 0.08 5 118125237 5.94 2.82e-09 VANGL2 58 rs174541 C 0.37 11 61565908 5.88 4.08e-09 VRK2, FANCL 59 rs12533568 A 0.27 7 156067051 5.83 5.43e-09 SDCCAG8, AKT3 60 rs1135999 G 0.31 16 15131962 5.79 6.89e-09 ACKR3 61 rs10797858 T 0.27 1 183151983 5.78 7.26e-09 MACF1, KIAA0754, BMP8A, PABPC4 62 rs1365658 G 0.5 18 35294554 5.77 7.76e-09 STAB1, NT5DC2, SMIM4, PBRM1, GNL3, GLT8D1, SPCS1, NEK4, ITIH1, ITIH3, ITIH4, RP5-966M1.6 63 rs12107379 G 0.44 3 79738224 5.77 8.14e-09 SSBP3 64 rs76928645 T 0.13 7 54941328 5.76 8.20e-09 CNTN2, TMEM81, RBBP5, DSTYK, TMCC2, NUAK2 65 rs167684 G 0.31 11 110962880 5.75 9.18e-09 FAM178B, FAHD2B, ANKRD36, COX5B, ACTR1B, ZAP70, TMEM131 66 rs1704668 T 0.39 14 92012673 5.7 1.18e-08 FAM117B, ICA1L, WDR12, CARF, NBEAL1, CYP20A1, ABI2 67 rs12448028 C 0.16 16 58708420 5.7 1.19e-08 MOBP 68 rs1570249 A 0.43 9 35752252 5.69 1.27e-08 VIT, AC007382.1, STRN, HEATR5B 69 rs2267158 C 0.34 22 30950360 5.69 1.28e-08 70 rs62005993 T 0.2 15 61772679 5.69 1.30e-08 TNS1 71 rs2231142 T 0.09 4 89052323 5.66 1.53e-08 CA14, APH1A, C1orf54, C1orf51, MRPS21, PRPF3, RPRD2, TARS2, ECM1, ADAMTSL4, AL356356.1 72 rs689411 G 0.34 8 108984290 5.59 2.25e-08 73 rs2273171 C 0.46 14 31381351 5.59 2.30e-08 ANKRD44, SF3B1, COQ10B, HSPD1, HSPE1, HSPE1-MOB4, MOB4, RFTN2, AC011997.1, MARS2, BOLL, PLCL1 74 rs7689064 C 0.16 4 23753053 5.58 2.42e-08 WNT2B, ST7L, CAPZA1, MOV10, RHOC, RP11-426L16.10, PPM1J 75 rs1410071 T 0.33 10 14680621 5.55 2.93e-08 SIX3 76 rs6496733 C 0.33 15 85673176 5.53 3.18e-08 EPHA4 77 rs77721014 T 0.21 22 23505899 5.52 3.40e-08 EPHA3 78 rs13388394 G 0.04 2 33764176 5.52 3.47e-08 AKR1A1, NASP, CCDC17, GPBP1L1, TMEM69, IPP, MAST2, PIK3R3 79 rs713978 G 0.16 22 46214351 5.52 3.49e-08 80 rs191699156 A 0.05 19 42654750 5.51 3.49e-08 MITF 81 rs72716328 T 0.05 8 130606932 5.51 3.57e-08 82 rs1007000 T 0.19 9 113662681 5.5 3.89e-08 CDC42EP3 83 rs61360336 G 0.12 9 126121731 5.49 3.96e-08 THADA, ZFP36L2, PLEKHH2 84 rs7630893 C 0.28 3 141759380 5.48 4.30e-08 ROR1 85 rs7228555 A 0.25 18 36007703 5.47 4.55e-08 ERC2 86 rs6951635 C 0.27 7 15610696 5.46 4.73e-08 CRB1, DENND1B 87 rs2045580 T 0.07 12 78521908 5.46 4.86e-08 LYPD6B 88 rs2364232 C 0.25 12 93994827 5.45 4.96e-08 TANK, PSMD14, TBR1 89 rs2978102 G 0.47 8 101679411 5.45 4.97e-08