Comparison Number,Outcome Number,Subgroup Number,Name,Data Type,Statistical Method,Effect Measure,Analysis Model,Totals,Study Confidence Interval,Total Confidence Interval,Test for subgroup differences,Swap event and non-event,Entered data are on log scale (Generic Inverse Variance only),"Enter number of participants (Generic Inverse Variance, for display only)",Events 1,Mean 1,SD 1,Total 1,Events 2,Mean 2,SD 2,Total 2,O-E,Var,Effect Estimate,SE,CI Start,CI End,Weight,Q,P(Q),I²(Q),Tau²,Z,P(Z),Qint,P(Qint),I²(Qint),df,Group Label 1,Group Label 2,Left Graph Label,Right Graph Label,Year of study,User defined order,Random sequence generation (selection bias),Allocation concealment (selection bias),Blinding of participants and personnel (performance bias),Blinding of outcome assessment (detection bias),Incomplete outcome data (attrition bias),Selective reporting (reporting bias),Other bias
1,0,0,Benznidazole fixed vs adjusted dose,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
2,0,0,Benznidazole at different fixed doses,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
2,1,0,Positive PCR (monotherapy),DIC,MH,Risk Ratio,Random,Subtotals only,95%,95%,Yes,No,,,,,,,,,,,,,,,,,,,,,,,,,,,,Benznidazole 150 mg/dia,Benznidazole 300 mg/dia,Favours benznidazole 150,Favours benznidazole 300,,,
2,1,1,Fixed 150 vs 300 8 weeks (follow-up 360 days),DIC,MH,Risk Ratio,Random,,,,,,,,2,,,10,6,,,30,,,1,,0.2389848,4.18436649,100,0,1,0,0,0,1,,,,0,Benznidazole 150 mg/dia,Benznidazole 300 mg/dia,Favours benznidazole 150,Favours benznidazole 300,,,
2,1,1,BENDITA 2017a,,,,,,,,,,,,2,0,0,10,6,0,0,30,0,0.53333333,1,0.73029674,0.2389848,4.18436649,100,,,,,,,,,,,,,,,2017,110,Low risk,Low risk,Low risk,Low risk,Low risk,Unclear risk,Low risk
2,1,2,Fixed 150 vs 300 4 weeks (follow-up 360 days),DIC,MH,Risk Ratio,Random,,,,,,,,2,,,10,5,,,30,,,1.2,,0.27442268,5.24737969,100,0,1,0,0,0.24220003,0.80862517,,,,0,Benznidazole 150 mg/dia,Benznidazole 300 mg/dia,Favours benznidazole 150,Favours benznidazole 300,,,
2,1,2,BENDITA 2017a,,,,,,,,,,,,2,0,0,10,5,0,0,30,0,0.56666667,1.2,0.75277265,0.27442268,5.24737969,100,,,,,,,,,,,,,,,2017,110,Low risk,Low risk,Low risk,Low risk,Low risk,Unclear risk,Low risk
2,1,3,Fixed 150 vs 300 2 weeks (follow-up 360 days),DIC,MH,Risk Ratio,Random,,,,,,,,2,,,10,7,,,30,,,0.85714286,,0.2115717,3.47255268,100,0,1,0,0,0.21595497,0.82902285,,,,0,Benznidazole 150 mg/dia,Benznidazole 300 mg/dia,Favours benznidazole 150,Favours benznidazole 300,,,
2,1,3,BENDITA 2017a,,,,,,,,,,,,2,0,0,10,7,0,0,30,0,0.50952381,0.85714286,0.71380936,0.2115717,3.47255268,100,,,,,,,,,,,,,,,2017,110,Low risk,Low risk,Low risk,Low risk,Low risk,Unclear risk,Low risk
2,2,0,Positive PCR (combined with E1224 3000mg total ),DIC,MH,Risk Ratio,Random,Totals and subtotals,95%,95%,Yes,No,,,23,,,30,24,,,30,,,0.95833333,,0.73419042,1.25090543,100,0,1,0,0,0.31308852,0.75421341,0,1,0,0,Benznidazole 150,Benznidazole 300,Favours Benznidazole 150,Favours Benznidazole 150,,,
2,2,2,150 mg/d for 4 weeks vs 300 for 8 weeks (follow-up 360 days),DIC,MH,Risk Ratio,Random,,,,,,,,23,,,30,24,,,30,,,0.95833333,,0.73419042,1.25090543,100,0,1,0,0,0.31308852,0.75421341,,,,0,Benznidazole 150,Benznidazole 300,Favours Benznidazole 150,Favours Benznidazole 150,,,
2,2,2,BENDITA 2017a,,,,,,,,,,,,23,0,0,30,24,0,0,30,0,0.01847826,0.95833333,0.13593477,0.73419042,1.25090543,100,,,,,,,,,,,,,,,2017,46,Low risk,Low risk,Low risk,Low risk,Low risk,Unclear risk,Low risk
2,3,0,Drug discontinuation due to AEs,DIC,MH,Risk Ratio,Random,Totals and subtotals,95%,95%,Yes,No,,,8,,,120,0,,,30,,,4.3553719,,0.25837695,73.41701478,100,0,1,0,0,1.02094521,0.30728041,0,1,0,0,Benznidazole,Control,Favours benznidazole,Favours control,,,
2,3,0,BENDITA 2017a,,,,,,,,,,,,8,0,0,120,0,0,0,30,0,2.07712453,4.3553719,1.44122328,0.25837695,73.41701478,100,,,,,,,,,,,,,,,2017,78,Low risk,Low risk,Low risk,Low risk,Low risk,Unclear risk,Low risk
2,4,0,Any Adverse events,DIC,MH,Risk Ratio,Random,Totals and subtotals,95%,95%,Yes,No,,,20,,,30,65,,,90,,,0.92695356,,0.69995246,1.22757323,100,0.40257719,0.8176765,0,0,0.52926862,0.59661912,0.40172206,0.81802618,0,2,Benznidazole 150,Benznidazole 300,Favours Benznidazole 150,Favours Benznidazole 300,,,
2,4,1,Fixed 150 vs 300 8 weeks (follow-up 360 days),DIC,MH,Risk Ratio,Random,,,,,,,,7,,,10,24,,,30,,,0.875,,0.56159217,1.36331138,40.12272835,0,1,0,0,0.59018585,0.55506606,,,,0,Benznidazole 150,Benznidazole 300,Favours Benznidazole 150,Favours Benznidazole 300,,,
2,4,1,BENDITA 2017a,,,,,,,,,,,,7,0,0,10,24,0,0,30,0,0.05119048,0.875,0.22625312,0.56159217,1.36331138,40.12272835,,,,,,,,,,,,,,,2017,312,Low risk,Low risk,Low risk,Low risk,Low risk,Unclear risk,Low risk
2,4,2,Fixed 150 vs 300 4 weeks (follow-up 360 days),DIC,MH,Risk Ratio,Random,,,,,,,,7,,,10,20,,,30,,,1.05,,0.65090467,1.69379642,34.50554638,0,1,0,0,0.19998016,0.84149609,,,,0,Benznidazole 150,Benznidazole 300,Favours Benznidazole 150,Favours Benznidazole 300,,,
2,4,2,BENDITA 2017a,,,,,,,,,,,,7,0,0,10,20,0,0,30,0,0.05952381,1.05,0.24397502,0.65090467,1.69379642,34.50554638,,,,,,,,,,,,,,,2017,110,Low risk,Low risk,Low risk,Low risk,Low risk,Unclear risk,Low risk
2,4,3,Fixed 150 vs 300 2 weeks (follow-up 360 days),DIC,MH,Risk Ratio,Random,,,,,,,,6,,,10,21,,,30,,,0.85714286,,0.49075895,1.49705652,25.37172528,0,1,0,0,0.54178956,0.58796349,,,,0,Benznidazole 150,Benznidazole 300,Favours Benznidazole 150,Favours Benznidazole 300,,,
2,4,3,BENDITA 2017a,,,,,,,,,,,,6,0,0,10,21,0,0,30,0,0.08095238,0.85714286,0.28452132,0.49075895,1.49705652,25.37172528,,,,,,,,,,,,,,,2017,110,Low risk,Low risk,Low risk,Low risk,Low risk,Unclear risk,Low risk
2,5,0,Any Serious Adverse events (SAE),DIC,PETO,Peto Odds Ratio,Fixed,Totals and subtotals,95%,95%,Yes,No,,,0,,,30,2,,,90,,,0.2545085,,0.00994318,6.51447431,100,0,1,0,0,0.82717019,0.40814061,0,1,0,0,Benznidazole 150,Benznidazole 300,Favours Benznidazole 150,Favours Benznidazole 300,,,
2,5,2,Fixed 150 vs 300 8 weeks (follow-up 360 days),DIC,PETO,Peto Odds Ratio,Fixed,,,,,,,,0,,,10,2,,,30,,,0.2545085,,0.00994318,6.51447431,100,0,1,0,0,0.82717019,0.40814061,,,,0,Benznidazole 150,Benznidazole 300,Favours Benznidazole 150,Favours Benznidazole 300,,,
2,5,2,BENDITA 2017a,,,,,,,,,,,,0,0,0,10,2,0,0,30,-0.5,0.36538462,0.2545085,1.65434038,0.00994318,6.51447431,100,,,,,,,,,,,,,,,2017,312,Low risk,Low risk,Low risk,Low risk,Low risk,Unclear risk,Low risk
2,5,3,Fixed 150 vs 300 4 weeks (follow-up 360 days),DIC,PETO,Peto Odds Ratio,Fixed,,,,,,,,0,,,10,0,,,30,,,0,,0,0,0,0,0,0,0,0,0,,,,0,Benznidazole 150,Benznidazole 300,Favours Benznidazole 150,Favours Benznidazole 300,,,
2,5,3,BENDITA 2017a,,,,,,,,,,,,0,0,0,10,0,0,0,30,0,0,0,0,0,0,0,,,,,,,,,,,,,,,2017,110,Low risk,Low risk,Low risk,Low risk,Low risk,Unclear risk,Low risk
2,5,4,Fixed 150 vs 300 2 weeks (follow-up 360 days),DIC,PETO,Peto Odds Ratio,Fixed,,,,,,,,0,,,10,0,,,30,,,0,,0,0,0,0,0,0,0,0,0,,,,0,Benznidazole 150,Benznidazole 300,Favours Benznidazole 150,Favours Benznidazole 300,,,
2,5,4,BENDITA 2017a,,,,,,,,,,,,0,0,0,10,0,0,0,30,0,0,0,0,0,0,0,,,,,,,,,,,,,,,2017,110,Low risk,Low risk,Low risk,Low risk,Low risk,Unclear risk,Low risk
3,0,0,Benznidazole versus Placebo: efficacy,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
3,1,0,Positive serology at one year,DIC,MH,Risk Ratio,Random,Totals and subtotals,95%,95%,Yes,No,,,289,,,339,341,,,357,,,0.9372945,,0.81593298,1.07670729,100,8.81673077,0.00298483,88.65792745,0.00888802,0.91531786,0.3600248,0,1,0,1,Benznidazole,Control,Favours benznidazole,Favours control,,,
3,1,1,Fixed dose,DIC,MH,Risk Ratio,Random,,,,,,,,0,,,0,0,,,0,,,0,,0,0,0,0,0,0,0,0,0,,,,0,Benznidazole,Control,Favours benznidazole,Favours control,,,
3,1,3,Adjusted dose,DIC,MH,Risk Ratio,Random,,,,,,,,289,,,339,341,,,357,,,0.9372945,,0.81593298,1.07670729,100,8.81673077,0.00298483,88.65792745,0.00888802,0.91531786,0.3600248,,,,1,Benznidazole,Control,Favours benznidazole,Favours control,,,
3,1,3,Rodriges Coura 1997,,,,,,,,,,,,26,0,0,26,24,0,0,24,0,0.00151514,1,0.03892478,0.92654639,1.07927678,48.11429309,,,,,,,,,,,,,,,1997,70,Low risk,Low risk,Unclear risk,Low risk,Low risk,Unclear risk,Low risk
3,1,3,TRAENA 2015a,,,,,,,,,,,,263,0,0,313,317,0,0,333,0,0.00075896,0.88266597,0.02754931,0.83626972,0.93163628,51.88570691,,,,,,,,,,,,,,,2015,106,Low risk,Low risk,Low risk,Low risk,High risk,Unclear risk,Unclear risk
3,2,0,Positive PCR,DIC,MH,Risk Ratio,Random,Totals and subtotals,95%,95%,Yes,No,,,58,,,373,260,,,347,,,0.19809608,,0.15586643,0.25176721,100,0.91213998,0.92281275,0,0,13.23525171,0,0.87856772,0.83059669,0,4,Benznidazole,Placebo,Favours benznidazole,Favours control,,,
3,2,1,Fixed dose 200 mg/d for 60 days (follow-up 180 days),DIC,MH,Risk Ratio,Random,,,,,,,,0,,,0,0,,,0,,,0,,0,0,0,0,0,0,0,0,0,,,,0,Benznidazole,Placebo,Favours benznidazole,Favours control,,,
3,2,1,Morillo 2017,,,,,,,,,,,,3,0,0,30,27,0,0,30,0,0,0,0,0,0,0,,,,,,,,,,,,,,,2017,44,Low risk,Low risk,High risk,Low risk,Low risk,Low risk,Low risk
3,2,2,Fixed dose 200 mg/d for 60 days (follow-up 360 days),DIC,MH,Risk Ratio,Random,,,,,,,,3,,,30,25,,,30,,,0.12,,0.04053285,0.35526737,4.87937719,0,1,0,0,3.82874602,0.0001288,,,,0,Benznidazole,Placebo,Favours benznidazole,Favours control,,,
3,2,2,Morillo 2017,,,,,,,,,,,,3,0,0,30,25,0,0,30,0,0.30666667,0.12,0.55377492,0.04053285,0.35526737,4.87937719,,,,,,,,,,,,,,,2017,44,Low risk,Low risk,High risk,Low risk,Low risk,Low risk,Low risk
3,2,3,Fixed dose 150 mg/d for 4 weeks (follow-up 360 days),DIC,MH,Risk Ratio,Random,,,,,,,,6,,,30,29,,,30,,,0.20689655,,0.10083274,0.42452665,11.12664815,0,1,0,0,4.29630521,0.00001737,,,,0,Benznidazole,Placebo,Favours benznidazole,Favours control,,,
3,2,3,BENDITA 2017a,,,,,,,,,,,,6,0,0,30,29,0,0,30,0,0.13448276,0.20689655,0.36671891,0.10083274,0.42452665,11.12664815,,,,,,,,,,,,,,,2017,308,Low risk,Low risk,Low risk,Low risk,Low risk,Unclear risk,Low risk
3,2,4,Fixed dose 300 mg/d any duration of treatment (follow-up 360 days),DIC,MH,Risk Ratio,Random,,,,,,,,18,,,90,29,,,30,,,0.20689655,,0.13614402,0.31441839,32.81893697,0,1,0,0,7.378621,0,,,,0,Benznidazole,Placebo,Favours benznidazole,Favours control,,,
3,2,4,BENDITA 2017a,,,,,,,,,,,,18,0,0,90,29,0,0,30,0,0.04559387,0.20689655,0.21352721,0.13614402,0.31441839,32.81893697,,,,,,,,,,,,,,,2017,309,Low risk,Low risk,Low risk,Low risk,Low risk,Unclear risk,Low risk
3,2,5,Adjusted dose ( 365 days),DIC,MH,Risk Ratio,Random,,,,,,,,31,,,223,177,,,257,,,0.20018051,,0.14317579,0.27988137,51.1750377,0.01175621,0.91365774,0,0,9.40685246,0,,,,1,Benznidazole,Placebo,Favours benznidazole,Favours control,,,
3,2,5,Torrico 2018,,,,,,,,,,,,8,0,0,45,43,0,0,47,0,0.104757,0.19431525,0.32366185,0.10303989,0.36644462,14.28393706,,,,,,,,,,,,,,,2018,30,Low risk,Low risk,Low risk,Unclear risk,Low risk,Low risk,Low risk
3,2,5,TRAENA 2015a,,,,,,,,,,,,23,0,0,178,134,0,0,210,0,0.04056107,0.20249874,0.20139778,0.13645587,0.3005055,36.89110065,,,,,,,,,,,,,,,2015,107,Low risk,Low risk,Low risk,Low risk,High risk,Unclear risk,Unclear risk
3,3,0,Positive xenodiagnosis,DIC,MH,Risk Ratio,Random,Totals and subtotals,95%,95%,Yes,No,,,2,,,110,23,,,67,,,0.05296443,,0.01289709,0.21750879,100,0,1,0,0,4.07656932,0.00004571,0,1,0,0,Benznidazole,Placebo,Favours benznidazole,Favours control,,,
3,3,1,Fixed dose,DIC,MH,Risk Ratio,Random,,,,,,,,0,,,0,0,,,0,,,0,,0,0,0,0,0,0,0,0,0,,,,0,Benznidazole,Placebo,Favours benznidazole,Favours control,,,
3,3,3,Adjusted dose,DIC,MH,Risk Ratio,Random,,,,,,,,2,,,110,23,,,67,,,0.05296443,,0.01289709,0.21750879,100,0,1,0,0,4.07656932,0.00004571,,,,0,Benznidazole,Placebo,Favours benznidazole,Favours control,,,
3,3,3,Rodriges Coura 1997,,,,,,,,,,,,2,0,0,110,23,0,0,67,0,0.51946198,0.05296443,0.72073711,0.01289709,0.21750879,100,,,,,,,,,,,,,,,1997,102,Low risk,Low risk,Unclear risk,Low risk,Low risk,Unclear risk,Low risk
3,4,0,Mean reduction PCR load (GMT at 365days),CON,IV,Std. Mean Difference,Random,Totals and subtotals,95%,95%,Yes,,,,0,,,225,0,,,255,,,-0.48081401,,-1.19227519,0.23064718,100,9.10042919,0.0025555,89.01150727,0.23575022,1.32456718,0.18531475,0,1,0,1,Benznidazole,Placebo,Favours benznidazole,Favours control,,,
3,4,1,Fixed Dose,CON,IV,Std. Mean Difference,Random,,,,,,,,0,,,0,0,,,0,,,0,,0,0,0,0,0,0,0,0,0,,,,0,Benznidazole,Placebo,Favours benznidazole,Favours control,,,
3,4,2,Adjusted dose,CON,IV,Std. Mean Difference,Random,,,,,,,,0,,,225,0,,,255,,,-0.48081401,,-1.19227519,0.23064718,100,9.10042919,0.0025555,89.01150727,0.23575022,1.32456718,0.18531475,,,,1,Benznidazole,Placebo,Favours benznidazole,Favours control,,,
3,4,2,Torrico 2018,,,,,,,,,,,,0,0.07,0.1022,47,0,0.91,1.3647,45,0,0.04780049,-0.87040847,0.21863324,-1.29892174,-0.4418952,46.47030184,,,,,,,,,,,,,,,2018,31,Low risk,Low risk,Low risk,Unclear risk,Low risk,Low risk,Low risk
3,4,2,TRAENA 2015a,,,,,,,,,,,,0,0.03,0.13,178,0,12.38,117.47,210,0,0.01040636,-0.14259854,0.10201154,-0.34253749,0.05734042,53.52969816,,,,,,,,,,,,,,,2015,70,Low risk,Low risk,Low risk,Low risk,High risk,Unclear risk,Unclear risk
3,5,0,Mean reduction of antibodies titres (conventional ELISA at 365days),CON,IV,Mean Difference,Random,Totals and subtotals,95%,95%,Yes,,,,0,,,47,0,,,45,,,0.01,,-0.16890931,0.18890931,100,0,1,0,0,0.1095507,0.91276571,0,1,0,0,Benznidazole,Placebo,Favours benznidazole,Favours control,,,
3,5,1,Fixed Dose,CON,IV,Mean Difference,Random,,,,,,,,0,,,0,0,,,0,,,0,,0,0,0,0,0,0,0,0,0,,,,0,Benznidazole,Placebo,Favours benznidazole,Favours control,,,
3,5,2,Adjusted dose,CON,IV,Mean Difference,Random,,,,,,,,0,,,47,0,,,45,,,0.01,,-0.16890931,0.18890931,100,0,1,0,0,0.1095507,0.91276571,,,,0,Benznidazole,Placebo,Favours benznidazole,Favours control,,,
3,5,2,Torrico 2018,,,,,,,,,,,,0,-0.14,0.4428,47,0,-0.15,0.4327,45,0,0.00833239,0.01,0.09128194,-0.16890931,0.18890931,100,,,,,,,,,,,,,,,2018,31,Low risk,Low risk,Low risk,Unclear risk,Low risk,Low risk,Low risk
3,6,0,Mean reduction of antibodies titres (AT CL−ELISA at 365days),CON,IV,Mean Difference,Random,Totals and subtotals,95%,95%,Yes,,,,0,,,47,0,,,45,,,0.01,,-0.07257816,0.09257816,100,0,1,0,0,0.23734652,0.81238798,0,1,0,0,Benznidazole,Placebo,Favours benznidazole,Favours control,,,
3,6,1,Fixed Dose,CON,IV,Mean Difference,Random,,,,,,,,0,,,0,0,,,0,,,0,,0,0,0,0,0,0,0,0,0,,,,0,Benznidazole,Placebo,Favours benznidazole,Favours control,,,
3,6,2,Adjusted dose,CON,IV,Mean Difference,Random,,,,,,,,0,,,47,0,,,45,,,0.01,,-0.07257816,0.09257816,100,0,1,0,0,0.23734652,0.81238798,,,,0,Benznidazole,Placebo,Favours benznidazole,Favours control,,,
3,6,2,Torrico 2018,,,,,,,,,,,,0,-0.01,0.2044,47,0,-0.02,0.1997,45,0,0.00177515,0.01,0.04213249,-0.07257816,0.09257816,100,,,,,,,,,,,,,,,2018,31,Low risk,Low risk,Low risk,Unclear risk,Low risk,Low risk,Low risk
3,7,0,New ECG abnormalities,DIC,MH,Risk Ratio,Random,Totals and subtotals,95%,95%,Yes,No,,,28,,,354,30,,,359,,,0.94651601,,0.57774733,1.55066499,100,0,1,0,0,0.21823932,0.82724265,0,1,0,0,Benznidazole,Control,Favours benznidazole,Favours control,,,
3,7,1,Adjusted dose,DIC,MH,Risk Ratio,Random,,,,,,,,28,,,354,30,,,359,,,0.94651601,,0.57774733,1.55066499,100,0,1,0,0,0.21823932,0.82724265,,,,0,Benznidazole,Control,Favours benznidazole,Favours control,,,
3,7,1,TRAENA 2015a,,,,,,,,,,,,28,0,0,354,30,0,0,359,0,0.06343724,0.94651601,0.25186751,0.57774733,1.55066499,100,,,,,,,,,,,,,,,2015,102,Low risk,Low risk,Low risk,Low risk,High risk,Unclear risk,Unclear risk
3,8,0,geometric mean (AT CL−ELISA at 365 days),CON,IV,Mean Difference,Random,Totals and subtotals,95%,95%,Yes,,,,0,,,47,0,,,45,,,-0.57,,-1.08208109,-0.05791891,100,0,1,0,0,2.18164562,0.0291357,0,1,0,0,Benznidazole,Placebo,Favours benznidazole,Favours control,,,
3,8,1,Fixed Dose,CON,IV,Mean Difference,Random,,,,,,,,0,,,0,0,,,0,,,0,,0,0,0,0,0,0,0,0,0,,,,0,Benznidazole,Placebo,Favours benznidazole,Favours control,,,
3,8,2,Adjusted dose,CON,IV,Mean Difference,Random,,,,,,,,0,,,47,0,,,45,,,-0.57,,-1.08208109,-0.05791891,100,0,1,0,0,2.18164562,0.0291357,,,,0,Benznidazole,Placebo,Favours benznidazole,Favours control,,,
3,8,2,Torrico 2018,,,,,,,,,,,,0,2.44,1.1239,47,0,3.01,1.3647,45,0,0.06826236,-0.57,0.26127066,-1.08208109,-0.05791891,100,,,,,,,,,,,,,,,2018,31,Low risk,Low risk,Low risk,Unclear risk,Low risk,Low risk,Low risk
3,9,0,Progression of cardiomyopathy,DIC,MH,Risk Ratio,Random,Totals and subtotals,95%,95%,Yes,No,,,49,,,354,56,,,359,,,0.88735876,,0.62270359,1.26449498,100,0,0,100,0,0.66132512,0.50840384,0,1,0,0,Benznidazole,Control,Favours benznidazole,Favours control,,,
3,9,1,Adjusted dose,DIC,MH,Risk Ratio,Random,,,,,,,,49,,,354,56,,,359,,,0.88735876,,0.62270359,1.26449498,100,0,0,100,0,0.66132512,0.50840384,,,,0,Benznidazole,Control,Favours benznidazole,Favours control,,,
3,9,1,TRAENA 2015a,,,,,,,,,,,,49,0,0,354,56,0,0,359,0,0.03265493,0.88735876,0.18070676,0.62270359,1.26449498,100,,,,,,,,,,,,,,,2015,102,Low risk,Low risk,Low risk,Low risk,High risk,Unclear risk,Unclear risk
3,10,0,Cardiovascular mortality,DIC,MH,Risk Ratio,Random,Totals and subtotals,95%,95%,Yes,No,,,7,,,354,6,,,359,,,1.18314501,,0.40159163,3.48571034,100,0,1,0,0,0.30506295,0.76031821,0,1,0,0,Benznidazole,Control,Favours benznidazolel,Favours control,,,
3,10,1,Adjusted dose,DIC,MH,Risk Ratio,Random,,,,,,,,7,,,354,6,,,359,,,1.18314501,,0.40159163,3.48571034,100,0,1,0,0,0.30506295,0.76031821,,,,0,Benznidazole,Control,Favours benznidazolel,Favours control,,,
3,10,1,TRAENA 2015a,,,,,,,,,,,,7,0,0,354,6,0,0,359,0,0.30391344,1.18314501,0.55128344,0.40159163,3.48571034,100,,,,,,,,,,,,,,,2015,102,Low risk,Low risk,Low risk,Low risk,High risk,Unclear risk,Unclear risk
3,11,0,Severe arrhythmia/Pacemarker/Heart Failure,DIC,MH,Risk Ratio,Random,Totals and subtotals,95%,95%,Yes,No,,,3,,,354,8,,,359,,,0.38029661,,0.10171714,1.42184017,100,0,1,0,0,1.43688522,0.15075061,0,1,0,0,Benznidazole,Control,Favours benznidazolel,Favours control,,,
3,11,1,Adjusted dose,DIC,MH,Risk Ratio,Random,,,,,,,,3,,,354,8,,,359,,,0.38029661,,0.10171714,1.42184017,100,0,1,0,0,1.43688522,0.15075061,,,,0,Benznidazole,Control,Favours benznidazolel,Favours control,,,
3,11,1,TRAENA 2015a,,,,,,,,,,,,3,0,0,354,8,0,0,359,0,0.45272296,0.38029661,0.67284691,0.10171714,1.42184017,100,,,,,,,,,,,,,,,2015,102,Low risk,Low risk,Low risk,Low risk,High risk,Unclear risk,Unclear risk
4,0,0,Benznidazole versus Placebo: safety,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
4,1,0,Drug discontinuation,DIC,MH,Risk Ratio,Random,Totals and subtotals,95%,95%,Yes,No,,,110,,,435,10,,,411,,,7.42023789,,2.51248986,21.91448863,100,4.06955834,0.1307096,50.85461778,0.47152284,3.62734124,0.00028635,0.12061187,0.72837187,0,2,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,1,1,Fixed dose,DIC,MH,Risk Ratio,Random,,,,,,,,10,,,30,1,,,30,,,10,,1.36372894,73.32835517,20.28687311,0,1,0,0,2.26514219,0.02350396,,,,0,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,1,1,Morillo 2017,,,,,,,,,,,,10,0,0,30,1,0,0,30,0,1.03333333,10,1.01653005,1.36372894,73.32835517,20.28687311,,,,,,,,,,,,,,,2017,48,Low risk,Low risk,High risk,Low risk,Low risk,Low risk,Low risk
4,1,2,Adjusted dose,DIC,MH,Risk Ratio,Random,,,,,,,,100,,,405,9,,,381,,,6.34941143,,1.26539902,31.85953574,79.71312689,4.06860852,0.04368734,75.42157237,1.04152496,2.24598897,0.02470471,,,,1,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,1,2,Rodriges Coura 1997,,,,,,,,,,,,11,0,0,53,2,0,0,24,0,0.5303745,2.49056604,0.72826815,0.59757867,10.380088,30.47101236,,,,,,,,,,,,,,,1997,73,Low risk,Low risk,Unclear risk,Low risk,Low risk,Unclear risk,Low risk
4,1,2,TRAENA 2015a,,,,,,,,,,,,89,0,0,352,7,0,0,357,0,0.14845107,12.89488636,0.38529348,6.05975564,27.43973589,49.24211453,,,,,,,,,,,,,,,2015,70,Low risk,Low risk,Low risk,Low risk,High risk,Unclear risk,Unclear risk
4,2,0,Any Adverse events,DIC,MH,Risk Ratio,Random,Totals and subtotals,95%,95%,Yes,No,,,111,,,150,34,,,60,,,1.36757014,,0.89139984,2.09810234,100,3.1382151,0.07647777,68.13475281,0.06541993,1.43350846,0.15171258,0,1,0,1,Benznidazole,Control,Favours benznidazole,Favours ccontrol,,,
4,2,1,Fixed dose,DIC,MH,Risk Ratio,Random,,,,,,,,111,,,150,34,,,60,,,1.36757014,,0.89139984,2.09810234,100,3.1382151,0.07647777,68.13475281,0.06541993,1.43350846,0.15171258,,,,1,Benznidazole,Control,Favours benznidazole,Favours ccontrol,,,
4,2,1,BENDITA 2017a,,,,,,,,,,,,85,0,0,120,19,0,0,30,0,0.02272962,1.11842105,0.15076345,0.8322911,1.50291845,54.09619263,,,,,,,,,,,,,,,2017,310,Low risk,Low risk,Low risk,Low risk,Low risk,Unclear risk,Low risk
4,2,1,Morillo 2017,,,,,,,,,,,,26,0,0,30,15,0,0,30,0,0.03846154,1.73333333,0.19611614,1.18017859,2.54575406,45.90380737,,,,,,,,,,,,,,,2017,47,Low risk,Low risk,High risk,Low risk,Low risk,Low risk,Low risk
4,2,2,Adjusted dose,DIC,MH,Risk Ratio,Random,,,,,,,,0,,,0,0,,,0,,,0,,0,0,0,0,0,0,0,0,0,,,,0,Benznidazole,Control,Favours benznidazole,Favours ccontrol,,,
4,3,0,Any Serious Adverse events (SAE),DIC,MH,Risk Ratio,Random,Totals and subtotals,95%,95%,Yes,No,,,5,,,150,1,,,60,,,2.22855407,,0.37605856,13.20659539,100,0.19972824,0.65494031,0,0,0.88268815,0.37740479,0,1,0,1,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,3,1,Fixed dose,DIC,MH,Risk Ratio,Random,,,,,,,,5,,,150,1,,,60,,,2.22855407,,0.37605856,13.20659539,100,0.19972824,0.65494031,0,0,0.88268815,0.37740479,,,,1,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,3,1,BENDITA 2017a,,,,,,,,,,,,2,0,0,120,0,0,0,30,0,2.35947747,1.28099174,1.53605907,0.06310307,26.00412113,34.93150349,,,,,,,,,,,,,,,2017,311,Low risk,Low risk,Low risk,Low risk,Low risk,Unclear risk,Low risk
4,3,1,Morillo 2017,,,,,,,,,,,,3,0,0,30,1,0,0,30,0,1.26666667,3,1.12546287,0.33046504,27.23434813,65.06849651,,,,,,,,,,,,,,,2017,46,Low risk,Low risk,High risk,Low risk,Low risk,Low risk,Low risk
4,3,2,Adjusted dose,DIC,MH,Risk Ratio,Random,,,,,,,,0,,,0,0,,,0,,,0,,0,0,0,0,0,0,0,0,0,,,,0,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,4,0,SAE: toxic hepatitis,DIC,MH,Risk Ratio,Random,Totals and subtotals,95%,95%,Yes,No,,,18,,,502,2,,,417,,,2.44579166,,0.64879872,9.21995781,100,1.03288961,0.30948127,3.18423278,0.04516332,1.32097109,0.186511,0.99332502,0.31893131,0,1,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,4,1,Fixed dose,DIC,MH,Risk Ratio,Random,,,,,,,,14,,,150,2,,,60,,,1.75,,0.42023593,7.287573,79.73249394,0,1,0,0,0.76886412,0.44197398,,,,0,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,4,1,BENDITA 2017a,,,,,,,,,,,,14,0,0,120,2,0,0,30,0,0.5297619,1.75,0.72784745,0.42023593,7.287573,79.73249394,,,,,,,,,,,,,,,2017,325,Low risk,Low risk,Low risk,Low risk,Low risk,Unclear risk,Low risk
4,4,1,Morillo 2017,,,,,,,,,,,,0,0,0,30,0,0,0,30,0,0,0,0,0,0,0,,,,,,,,,,,,,,,2017,50,Low risk,Low risk,High risk,Low risk,Low risk,Low risk,Low risk
4,4,2,Adjusted dose,DIC,MH,Risk Ratio,Random,,,,,,,,4,,,352,0,,,357,,,9.12747875,,0.49324397,168.90397776,20.26750606,0,1,0,0,1.48525946,0.13747511,,,,0,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,4,2,TRAENA 2015a,,,,,,,,,,,,4,0,0,352,0,0,0,357,0,2.21659606,9.12747875,1.48882372,0.49324397,168.90397776,20.26750606,,,,,,,,,,,,,,,2015,71,Low risk,Low risk,Low risk,Low risk,High risk,Unclear risk,Unclear risk
4,5,0,SAE: Arthritis,DIC,MH,Risk Ratio,Random,Totals and subtotals,95%,95%,Yes,No,,,10,,,352,1,,,357,,,10.14204545,,1.30517964,78.80990706,100,0,1,0,0,2.21456364,0.02679003,0,1,0,0,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,5,1,Fixed dose,DIC,MH,Risk Ratio,Random,,,,,,,,0,,,0,0,,,0,,,0,,0,0,0,0,0,0,0,0,0,,,,0,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,5,2,Adjusted dose,DIC,MH,Risk Ratio,Random,,,,,,,,10,,,352,1,,,357,,,10.14204545,,1.30517964,78.80990706,100,0,1,0,0,2.21456364,0.02679003,,,,0,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,5,2,TRAENA 2015a,,,,,,,,,,,,10,0,0,352,1,0,0,357,0,1.09435797,10.14204545,1.04611566,1.30517964,78.80990706,100,,,,,,,,,,,,,,,2015,72,Low risk,Low risk,Low risk,Low risk,High risk,Unclear risk,Unclear risk
4,6,0,SAE: Peripheral neuropathy,DIC,MH,Risk Ratio,Random,Totals and subtotals,95%,95%,Yes,No,,,12,,,502,1,,,417,,,4.27472085,,0.94182219,19.40200448,100,1.93207442,0.38058833,0,0,1.88230077,0.05979519,1.49673414,0.22117492,33.18786735,2,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,6,1,Fixed dose,DIC,MH,Risk Ratio,Random,,,,,,,,2,,,150,0,,,60,,,1.52323353,,0.16203947,14.31898318,45.57158726,0.35818196,0.5495179,0,0,0.36810084,0.71279805,,,,1,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,6,1,BENDITA 2017a,,,,,,,,,,,,1,0,0,120,0,0,0,30,0,2.62614414,0.76859504,1.62053823,0.03208433,18.412053,22.68122545,,,,,,,,,,,,,,,2017,319,Low risk,Low risk,Low risk,Low risk,Low risk,Unclear risk,Low risk
4,6,1,Morillo 2017,,,,,,,,,,,,1,0,0,30,0,0,0,30,0,2.60215054,3,1.61311827,0.12706692,70.8288208,22.89036181,,,,,,,,,,,,,,,2017,49,Low risk,Low risk,High risk,Low risk,Low risk,Low risk,Low risk
4,6,2,Adjusted dose,DIC,MH,Risk Ratio,Random,,,,,,,,10,,,352,1,,,357,,,10.14204545,,1.30517964,78.80990706,54.42841274,0,1,0,0,2.21456364,0.02679003,,,,0,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,6,2,TRAENA 2015a,,,,,,,,,,,,10,0,0,352,1,0,0,357,0,1.09435797,10.14204545,1.04611566,1.30517964,78.80990706,54.42841274,,,,,,,,,,,,,,,2015,73,Low risk,Low risk,Low risk,Low risk,High risk,Unclear risk,Unclear risk
4,7,0,SAE: Lymphadenopathy,DIC,PETO,Peto Odds Ratio,Fixed,Totals and subtotals,95%,95%,Yes,No,,,10,,,472,0,,,387,,,7.27468502,,2.04446221,25.8850674,100,0.09250204,0.76102013,0,0,3.06425473,0.00218213,0.09250204,0.76102013,0,1,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,7,1,Fixed dose,DIC,PETO,Peto Odds Ratio,Fixed,,,,,,,,1,,,120,0,,,30,,,3.49034296,,0.02599347,468.675186,6.7100988,0,1,0,0,0.5,0.61707508,,,,0,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,7,1,BENDITA 2017a,,,,,,,,,,,,1,0,0,120,0,0,0,30,0.2,0.16,3.49034296,2.5,0.02599347,468.675186,6.7100988,,,,,,,,,,,,,,,2017,326,Low risk,Low risk,Low risk,Low risk,Low risk,Unclear risk,Low risk
4,7,2,Adjusted dose,DIC,PETO,Peto Odds Ratio,Fixed,,,,,,,,9,,,352,0,,,357,,,7.66928987,,2.06081879,28.54108643,93.2899012,0,1,0,0,3.03844682,0.00237801,,,,0,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,7,2,TRAENA 2015a,,,,,,,,,,,,9,0,0,352,0,0,0,357,4.53173484,2.22446564,7.66928987,0.67048204,2.06081879,28.54108643,93.2899012,,,,,,,,,,,,,,,2015,74,Low risk,Low risk,Low risk,Low risk,High risk,Unclear risk,Unclear risk
4,8,0,SAE: Oedema,DIC,MH,Risk Ratio,Random,Totals and subtotals,95%,95%,Yes,No,,,19,,,352,5,,,357,,,3.85397727,,1.45505242,10.20797645,100,0,1,0,0,2.71460522,0.00663548,0,1,0,0,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,8,1,Fixed dose,DIC,MH,Risk Ratio,Random,,,,,,,,0,,,0,0,,,0,,,0,,0,0,0,0,0,0,0,0,0,,,,0,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,8,2,Adjusted dose,DIC,MH,Risk Ratio,Random,,,,,,,,19,,,352,5,,,357,,,3.85397727,,1.45505242,10.20797645,100,0,1,0,0,2.71460522,0.00663548,,,,0,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,8,2,TRAENA 2015a,,,,,,,,,,,,19,0,0,352,5,0,0,357,0,0.24698955,3.85397727,0.49698043,1.45505242,10.20797645,100,,,,,,,,,,,,,,,2015,75,Low risk,Low risk,Low risk,Low risk,High risk,Unclear risk,Unclear risk
4,9,0,SAE: Fever,DIC,MH,Risk Ratio,Random,Totals and subtotals,95%,95%,Yes,No,,,20,,,472,1,,,387,,,8.09425955,,1.26242279,51.89785721,100,1.20981196,0.27136943,17.34252683,0.33974407,2.20576897,0.02740018,1.1756662,0.27824009,14.94184305,1,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,9,1,Fixed dose,DIC,MH,Risk Ratio,Random,,,,,,,,4,,,120,0,,,30,,,2.30578512,,0.12751021,41.69583711,35.64537299,0,1,0,0,0.56559821,0.57166695,,,,0,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,9,1,BENDITA 2017a,,,,,,,,,,,,4,0,0,120,0,0,0,30,0,2.18169969,2.30578512,1.47705778,0.12751021,41.69583711,35.64537299,,,,,,,,,,,,,,,2017,327,Low risk,Low risk,Low risk,Low risk,Low risk,Unclear risk,Low risk
4,9,2,Adjusted dose,DIC,MH,Risk Ratio,Random,,,,,,,,16,,,352,1,,,357,,,16.22727273,,2.16361371,121.70581966,64.35462701,0,1,0,0,2.71069631,0.00671421,,,,0,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,9,2,TRAENA 2015a,,,,,,,,,,,,16,0,0,352,1,0,0,357,0,1.05685797,16.22727273,1.02803598,2.16361371,121.70581966,64.35462701,,,,,,,,,,,,,,,2015,76,Low risk,Low risk,Low risk,Low risk,High risk,Unclear risk,Unclear risk
4,10,0,SAE: Severe skin reactions,DIC,MH,Risk Ratio,Random,Totals and subtotals,95%,95%,Yes,No,,,1,,,30,0,,,30,,,3,,0.12706692,70.8288208,100,0,1,0,0,0.68104882,0.49584061,0,1,0,0,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,10,1,Fixed dose,DIC,MH,Risk Ratio,Random,,,,,,,,1,,,30,0,,,30,,,3,,0.12706692,70.8288208,100,0,1,0,0,0.68104882,0.49584061,,,,0,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,10,1,Morillo 2017,,,,,,,,,,,,1,0,0,30,0,0,0,30,0,2.60215054,3,1.61311827,0.12706692,70.8288208,100,,,,,,,,,,,,,,,2017,50,Low risk,Low risk,High risk,Low risk,Low risk,Low risk,Low risk
4,10,2,Adjusted dose,DIC,MH,Risk Ratio,Random,,,,,,,,0,,,0,0,,,0,,,0,,0,0,0,0,0,0,0,0,0,,,,0,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,11,0,SAE: gastrointestinal,DIC,MH,Risk Ratio,Random,Totals and subtotals,95%,95%,Yes,No,,,0,,,0,0,,,0,,,0,,0,0,0,0,0,0,�,0,0,0,0,0,0,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,11,1,Fixed dose,DIC,MH,Risk Ratio,Random,,,,,,,,0,,,0,0,,,0,,,0,,0,0,0,0,0,0,0,0,0,,,,0,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,11,2,Adjusted dose,DIC,MH,Risk Ratio,Random,,,,,,,,0,,,0,0,,,0,,,0,,0,0,0,0,0,0,0,0,0,,,,0,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,12,0,SAE: Abortion spontaneous,DIC,MH,Risk Ratio,Random,Totals and subtotals,95%,95%,Yes,No,,,1,,,30,0,,,30,,,3,,0.12706692,70.8288208,100,0,1,0,0,0.68104882,0.49584061,0,1,0,0,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,12,1,Fixed dose,DIC,MH,Risk Ratio,Random,,,,,,,,1,,,30,0,,,30,,,3,,0.12706692,70.8288208,100,0,1,0,0,0.68104882,0.49584061,,,,0,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,12,1,Morillo 2017,,,,,,,,,,,,1,0,0,30,0,0,0,30,0,2.60215054,3,1.61311827,0.12706692,70.8288208,100,,,,,,,,,,,,,,,2017,50,Low risk,Low risk,High risk,Low risk,Low risk,Low risk,Low risk
4,12,2,Adjusted dose,DIC,MH,Risk Ratio,Random,,,,,,,,0,,,0,0,,,0,,,0,,0,0,0,0,0,0,0,0,0,,,,0,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,13,0,Non-SAE: Pruritus,DIC,MH,Risk Ratio,Random,Totals and subtotals,95%,95%,Yes,No,,,116,,,472,29,,,387,,,3.21671026,,2.17589241,4.75539364,100,0.10757111,0.74292656,0,0,5.85782301,0,0.10559258,0.74521886,0,1,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,13,1,Fixed dose,DIC,MH,Risk Ratio,Random,,,,,,,,32,,,120,2,,,30,,,4,,1.01501462,15.76331971,8.12556622,0,1,0,0,1.98126307,0.04756178,,,,0,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,13,1,BENDITA 2017a,,,,,,,,,,,,32,0,0,120,2,0,0,30,0,0.48958333,4,0.69970232,1.01501462,15.76331971,8.12556622,,,,,,,,,,,,,,,2017,320,Low risk,Low risk,Low risk,Low risk,Low risk,Unclear risk,Low risk
4,13,2,Adjusted dose,DIC,MH,Risk Ratio,Random,,,,,,,,84,,,352,27,,,357,,,3.15530303,,2.09854351,4.7442129,91.87443378,0,1,0,0,5.52216259,0.00000003,,,,0,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,13,2,TRAENA 2015a,,,,,,,,,,,,84,0,0,352,27,0,0,357,0,0.04329977,3.15530303,0.20808597,2.09854351,4.7442129,91.87443378,,,,,,,,,,,,,,,2015,141,Low risk,Low risk,Low risk,Low risk,High risk,Unclear risk,Unclear risk
4,14,0,Non-SAE: Mild rash,DIC,MH,Risk Ratio,Random,Totals and subtotals,95%,95%,Yes,No,,,161,,,502,28,,,417,,,5.31943175,,3.65583171,7.74005928,100,0.13927348,0.9327326,0,0,8.73451661,0,0.10462241,0.74635157,0,2,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,14,1,Fixed dose,DIC,MH,Risk Ratio,Random,,,,,,,,33,,,150,3,,,60,,,6.2355832,,2.21870688,17.52484666,13.17252295,0.03617115,0.84916254,0,0,3.47150128,0.00051756,,,,1,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,14,1,BENDITA 2017a,,,,,,,,,,,,15,0,0,120,0,0,0,30,0,2.0239936,7.94214876,1.42267129,0.48860513,129.09755453,1.80907467,,,,,,,,,,,,,,,2017,321,Low risk,Low risk,Low risk,Low risk,Low risk,Unclear risk,Low risk
4,14,1,Morillo 2017,,,,,,,,,,,,18,0,0,30,3,0,0,30,0,0.32222222,6,0.56764621,1.97228612,18.25292974,11.36344828,,,,,,,,,,,,,,,2017,53,Low risk,Low risk,High risk,Low risk,Low risk,Low risk,Low risk
4,14,2,Adjusted dose,DIC,MH,Risk Ratio,Random,,,,,,,,128,,,352,25,,,357,,,5.19272727,,3.47214175,7.76593195,86.82747705,0,1,0,0,8.0215386,0,,,,0,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,14,2,TRAENA 2015a,,,,,,,,,,,,128,0,0,352,25,0,0,357,0,0.04217047,5.19272727,0.2053545,3.47214175,7.76593195,86.82747705,,,,,,,,,,,,,,,2015,77,Low risk,Low risk,Low risk,Low risk,High risk,Unclear risk,Unclear risk
4,15,0,Non-SAE: Moderate rash,DIC,MH,Risk Ratio,Random,Totals and subtotals,95%,95%,Yes,No,,,91,,,472,12,,,387,,,6.41798719,,3.59903702,11.44488355,100,0.04007932,0.84132566,0,0,6.29933803,0,0.03929427,0.84286691,0,1,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,15,1,Fixed dose,DIC,MH,Risk Ratio,Random,,,,,,,,16,,,120,0,,,30,,,8.45454545,,0.52153151,137.05660676,4.31169934,0,1,0,0,1.50194159,0.13311219,,,,0,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,15,1,BENDITA 2017a,,,,,,,,,,,,16,0,0,120,0,0,0,30,0,2.02008353,8.45454545,1.42129643,0.52153151,137.05660676,4.31169934,,,,,,,,,,,,,,,2017,322,Low risk,Low risk,Low risk,Low risk,Low risk,Unclear risk,Low risk
4,15,2,Adjusted dose,DIC,MH,Risk Ratio,Random,,,,,,,,75,,,352,12,,,357,,,6.33877841,,3.50909883,11.45026506,95.68830066,0,1,0,0,6.12087619,0,,,,0,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,15,2,TRAENA 2015a,,,,,,,,,,,,75,0,0,352,12,0,0,357,0,0.09102464,6.33877841,0.3017029,3.50909883,11.45026506,95.68830066,,,,,,,,,,,,,,,2015,78,Low risk,Low risk,Low risk,Low risk,High risk,Unclear risk,Unclear risk
4,16,0,Non-SAE: Headache,DIC,MH,Risk Ratio,Random,Totals and subtotals,95%,95%,Yes,No,,,118,,,472,80,,,387,,,1.15724771,,0.89507448,1.4962132,100,0.0336284,0.85449955,0,0,1.1142466,0.26517343,0.03361941,0.85451877,0,1,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,16,1,Fixed dose,DIC,MH,Risk Ratio,Random,,,,,,,,35,,,120,8,,,30,,,1.09375,,0.56777032,2.10699471,15.35180081,0,1,0,0,0.26788146,0.78879057,,,,0,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,16,1,BENDITA 2017a,,,,,,,,,,,,35,0,0,120,8,0,0,30,0,0.11190476,1.09375,0.33452169,0.56777032,2.10699471,15.35180081,,,,,,,,,,,,,,,2017,318,Low risk,Low risk,Low risk,Low risk,Low risk,Unclear risk,Low risk
4,16,2,Adjusted dose,DIC,MH,Risk Ratio,Random,,,,,,,,83,,,352,72,,,357,,,1.16915246,,0.88431782,1.54573101,84.64819919,0,1,0,0,1.09699791,0.27264232,,,,0,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,16,2,TRAENA 2015a,,,,,,,,,,,,83,0,0,352,72,0,0,357,0,0.02029505,1.16915246,0.1424607,0.88431782,1.54573101,84.64819919,,,,,,,,,,,,,,,2015,79,Low risk,Low risk,Low risk,Low risk,High risk,Unclear risk,Unclear risk
4,17,0,Non-SAE: Insomnia,DIC,PETO,Peto Odds Ratio,Fixed,Totals and subtotals,95%,95%,Yes,No,,,17,,,472,8,,,387,,,2.05098258,,0.91925592,4.57601571,100,0.04647623,0.8293126,0,0,1.75434557,0.07937131,0.04647623,0.8293126,0,1,Benznidazole,Control,Favours benznidazolel,Favours control,,,
4,17,1,Fixed dose,DIC,PETO,Peto Odds Ratio,Fixed,,,,,,,,1,,,120,0,,,30,,,3.49034296,,0.02599347,468.675186,2.68240521,0,1,0,0,0.5,0.61707508,,,,0,Benznidazole,Control,Favours benznidazolel,Favours control,,,
4,17,1,BENDITA 2017a,,,,,,,,,,,,1,0,0,120,0,0,0,30,0.2,0.16,3.49034296,2.5,0.02599347,468.675186,2.68240521,,,,,,,,,,,,,,,2017,328,Low risk,Low risk,Low risk,Low risk,Low risk,Unclear risk,Low risk
4,17,2,Adjusted dose,DIC,PETO,Peto Odds Ratio,Fixed,,,,,,,,16,,,352,8,,,357,,,2.02114471,,0.89598605,4.55925174,97.31759479,0,1,0,0,1.69534793,0.09000944,,,,0,Benznidazole,Control,Favours benznidazolel,Favours control,,,
4,17,2,TRAENA 2015a,,,,,,,,,,,,16,0,0,352,8,0,0,357,4.08462623,5.80479604,2.02114471,0.41505583,0.89598605,4.55925174,97.31759479,,,,,,,,,,,,,,,2015,80,Low risk,Low risk,Low risk,Low risk,High risk,Unclear risk,Unclear risk
4,18,0,Non-SAE: Gastrointestinal,DIC,MH,Risk Ratio,Random,Totals and subtotals,95%,95%,Yes,No,,,36,,,150,11,,,60,,,1.31690918,,0.71060422,2.44052845,100,0.23809075,0.62558852,0,0,0.87458225,0.38180126,0,1,0,1,Benznidazole,Control,Favours benznidazolel,Favours control,,,
4,18,1,Fixed dose,DIC,MH,Risk Ratio,Random,,,,,,,,36,,,150,11,,,60,,,1.31690918,,0.71060422,2.44052845,100,0.23809075,0.62558852,0,0,0.87458225,0.38180126,,,,1,Benznidazole,Control,Favours benznidazolel,Favours control,,,
4,18,1,BENDITA 2017a,,,,,,,,,,,,28,0,0,120,6,0,0,30,0,0.16071429,1.16666667,0.40089186,0.53174941,2.55968523,61.64772727,,,,,,,,,,,,,,,2017,324,Low risk,Low risk,Low risk,Low risk,Low risk,Unclear risk,Low risk
4,18,1,Morillo 2017,,,,,,,,,,,,8,0,0,30,5,0,0,30,0,0.25833333,1.6,0.50826502,0.59085921,4.33267342,38.35227273,,,,,,,,,,,,,,,2017,53,Low risk,Low risk,High risk,Low risk,Low risk,Low risk,Low risk
4,18,2,Adjusted dose,DIC,MH,Risk Ratio,Random,,,,,,,,0,,,0,0,,,0,,,0,,0,0,0,0,0,0,0,0,0,,,,0,Benznidazole,Control,Favours benznidazolel,Favours control,,,
4,19,0,Non-SAE: Nervous system disorders,DIC,MH,Risk Ratio,Random,Totals and subtotals,95%,95%,Yes,No,,,45,,,150,11,,,60,,,1.70711022,,0.57927392,5.03082427,100,2.6485149,0.10364674,62.24299132,0.39446606,0.96984669,0.33212293,0,1,0,1,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,19,1,Fixed dose,DIC,MH,Risk Ratio,Random,,,,,,,,45,,,150,11,,,60,,,1.70711022,,0.57927392,5.03082427,100,2.6485149,0.10364674,62.24299132,0.39446606,0.96984669,0.33212293,,,,1,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,19,1,BENDITA 2017a,,,,,,,,,,,,35,0,0,120,8,0,0,30,0,0.11190476,1.09375,0.33452169,0.56777032,2.10699471,60.04975107,,,,,,,,,,,,,,,2017,323,Low risk,Low risk,Low risk,Low risk,Low risk,Unclear risk,Low risk
4,19,1,Morillo 2017,,,,,,,,,,,,10,0,0,30,3,0,0,30,0,0.36666667,3.33333333,0.60553007,1.01730368,10.9221183,39.95024893,,,,,,,,,,,,,,,2017,55,Low risk,Low risk,High risk,Low risk,Low risk,Low risk,Low risk
4,19,2,Adjusted dose,DIC,MH,Risk Ratio,Random,,,,,,,,0,,,0,0,,,0,,,0,,0,0,0,0,0,0,0,0,0,,,,0,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,20,0,Non-SAE: Mild hepatitis (ALAT x 3+),DIC,MH,Risk Ratio,Random,Totals and subtotals,95%,95%,Yes,No,,,2,,,30,1,,,30,,,2,,0.19140591,20.89799668,100,0,1,0,0,0.5789644,0.5626132,0,1,0,0,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,20,1,Fixed dose,DIC,MH,Risk Ratio,Random,,,,,,,,2,,,30,1,,,30,,,2,,0.19140591,20.89799668,100,0,1,0,0,0.5789644,0.5626132,,,,0,Benznidazole,Control,Favours benznidazole,Favours control,,,
4,20,1,Morillo 2017,,,,,,,,,,,,2,0,0,30,1,0,0,30,0,1.43333333,2,1.197219,0.19140591,20.89799668,100,,,,,,,,,,,,,,,2017,55,Low risk,Low risk,High risk,Low risk,Low risk,Low risk,Low risk
4,20,2,Adjusted dose,DIC,MH,Risk Ratio,Random,,,,,,,,0,,,0,0,,,0,,,0,,0,0,0,0,0,0,0,0,0,,,,0,Benznidazole,Control,Favours benznidazole,Favours control,,,
5,0,0,Benznidazole versus Posaconazole,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,
5,2,0,Positive PCR,DIC,MH,Risk Ratio,Random,Totals and subtotals,95%,95%,Yes,No,,,13,,,56,49,,,56,,,0.24173787,,0.0625955,0.93356863,100,5.19987062,0.02258862,80.7687523,0.77993751,2.05967788,0.03942935,4.17197443,0.04109801,76.0305338,1,Benznidazol,Posaconazol,Favours bendnidazol,Favours posaconazol,,,
5,2,1,"Fixed low dose of Posaconazol, follow-up 168 days",DIC,MH,Risk Ratio,Random,,,,,,,,0,,,0,0,,,0,,,0,,0,0,0,0,0,0,0,0,0,,,,0,Benznidazol,Posaconazol,Favours bendnidazol,Favours posaconazol,,,
5,2,2,"Fixed low dose of Posaconazol, follow-up 280 days",DIC,MH,Risk Ratio,Random,,,,,,,,10,,,26,24,,,26,,,0.41666667,,0.25304779,0.68608032,56.26326621,0,1,0,0,3.44066393,0.00058029,,,,0,Benznidazol,Posaconazol,Favours bendnidazol,Favours posaconazol,,,
5,2,2,Molina 2014,,,,,,,,,,,,10,0,0,26,24,0,0,26,0,0.06474359,0.41666667,0.25444762,0.25304779,0.68608032,56.26326621,,,,,,,,,,,,,,,2014,60,Low risk,Low risk,High risk,Low risk,Low risk,Low risk,Low risk
5,2,3,Fixed dose (follow-up 180 days),DIC,MH,Risk Ratio,Random,,,,,,,,0,,,0,0,,,0,,,0,,0,0,0,0,0,0,0,0,0,,,,0,Benznidazol,Posaconazol,Favours bendnidazol,Favours posaconazol,,,
5,2,3,Morillo 2017,,,,,,,,,,,,3,0,0,30,4,0,0,30,0,0,0,0,0,0,0,,,,,,,,,,,,,,,2017,44,Low risk,Low risk,High risk,Low risk,Low risk,Low risk,Low risk
5,2,4,Fixed dose (follow-up 360 days),DIC,MH,Risk Ratio,Random,,,,,,,,3,,,30,25,,,30,,,0.12,,0.04053285,0.35526737,43.73673379,0,1,0,0,3.82874602,0.0001288,,,,0,Benznidazol,Posaconazol,Favours bendnidazol,Favours posaconazol,,,
5,2,4,Morillo 2017,,,,,,,,,,,,3,0,0,30,25,0,0,30,0,0.30666667,0.12,0.55377492,0.04053285,0.35526737,43.73673379,,,,,,,,,,,,,,,2017,44,Low risk,Low risk,High risk,Low risk,Low risk,Low risk,Low risk